WorldWideScience

Sample records for proc 12th onr

  1. ONR Ocean Wave Dynamics Workshop

    Science.gov (United States)

    In anticipation of the start (in Fiscal Year 1988) of a new Office of Naval Research (ONR) Accelerated Research Initiative (ARI) on Ocean Surface Wave Dynamics, a workshop was held August 5-7, 1986, at Woods Hole, Mass., to discuss new ideas and directions of research. This new ARI on Ocean Surface Wave Dynamics is a 5-year effort that is organized by the ONR Physical Oceanography Program in cooperation with the ONR Fluid Mechanics Program and the Physical Oceanography Branch at the Naval Ocean Research and Development Activity (NORDA). The central theme is improvement of our understanding of the basic physics and dynamics of surface wave phenomena, with emphasis on the following areas: precise air-sea coupling mechanisms,dynamics of nonlinear wave-wave interaction under realistic environmental conditions,wave breaking and dissipation of energy,interaction between surface waves and upper ocean boundary layer dynamics, andsurface statistical and boundary layer coherent structures.

  2. Computational mechanics research at ONR

    International Nuclear Information System (INIS)

    Kushner, A.S.

    1986-01-01

    Computational mechanics is not an identified program at the Office of Naval Research (ONR), but rather plays a key role in the Solid Mechanics, Fluid Mechanics, Energy Conversion, and Materials Science programs. The basic philosophy of the Mechanics Division at ONR is to support fundamental research which expands the basis for understanding, predicting, and controlling the behavior of solid and fluid materials and systems at the physical and geometric scales appropriate to the phenomena of interest. It is shown in this paper that a strong commonalty of computational mechanics drivers exists for the forefront research areas in both solid and fluid mechanics

  3. NEA/IAEA Workshop on Leadership and Management for Safety. ONR approach

    International Nuclear Information System (INIS)

    Harvey, Paul

    2012-01-01

    Paul Harvey summarised the progress made by the UK ONR on oversight of LMfS since the previous workshop in 2007. The ONR approach is based on published Safety Assessment Principles (SAPs) on Leadership and Management for Safety. The four principles cover Leadership, Capable Organisation, Decision Making and Learning. Safety culture is embodied within the LMfS SAPs/strategy rather than being treated as a specific topic. The ONR LMfS strategy draws on the lessons from major events (e.g., Texas City, Davis Besse, Columbia) and includes integration of LMfS into existing types of regulatory interventions. Key elements of the strategy include more attention to organisational and cultural factors, increased focus on Board/Director/Executive Team levels in licensees, more focus on how licensees oversee themselves, and improving ONR ability to identify precursors and influencing in combination with regulation. Guidance on Leadership and Management for safety has been produced and is undergoing trial use by ONR inspectors. The guidance is structured around the four LMfS safety assessment principles. It provides help on what to look for during interactions with licensees. ONR staff record significant points (both potential concerns and good practices) in their Intervention Reports under the 'LMfS' heading. This should enable ONR to build up a picture of strengths and weaknesses and plan interventions. Workshops on LMfS have been held for inspectors and managers. These cover organisational and cultural lessons from a range of major events and relate these to ONR LMfS strategy and draft guidance. Other interventions which form part of the strategy include 'deep slice' inspections on specific LMfS topics, and interactions with some licensee Company Boards on lessons from major events and the ONR LMfS strategy. These have been received positively by licensees. It was concluded that ongoing effort is needed to fully implement and embed the ONR LMfS strategy

  4. ProcSee - The Picasso successor

    International Nuclear Information System (INIS)

    Randem, Hans Olav; Jokstad, Haakon; Linden, Terje; Kvilesjoe, Hans Oeyvind; Rekvin, Sverre; Hornaes, Arne

    2005-09-01

    This report describes the history of computer graphics and Picasso at the Halden Project and how Picasso has been used at HRP, in HRP member organisations and in other organisations. It motivates the change of name from Picasso to ProcSee based on plans to extend the use of the product and to avoid a potential conflict regarding the name. It describes features introduced during the last years to motivate users to utilise new functionality, describes how tests shows that ProcSee has unique capabilities when it comes to performance for handling frequent display updates for large complex displays, and describes new planned features to be implemented in ProcSee. The report concludes that Picasso/ProcSee has been and will continue to be of vital importance for the HRP research programme within the fields of human-machine interface design and human-machine interaction. (Author)

  5. The WIMS-E module W-PROC

    International Nuclear Information System (INIS)

    Roth, M.J.; Harris, D.W.G.

    1980-07-01

    The program W-PROC is a module of the WIMS-E Scheme for neutronics calculations. W-PROC calculates collision probabilities for a system consisting of spherical grains packed in annular geometry, such as the fuel in a high temperature gas cooled reactor. This report describes the modelling approximations made and gives instructions for using the program. (U.K.)

  6. An enhanced Planetary Radar Operating Centre (PROC)

    Science.gov (United States)

    Catallo, C.

    2010-12-01

    Planetary exploration by means of radar systems, mainly using GPRs is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are successfully operating: MARSIS on-board MEX, SHARAD on-board MRO and CASSINI Radar on-board Cassini spacecraft: the missions have been further extended . Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the missions beginning to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how the new PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation aiding scientists to increase their knowledge in the field of surface

  7. ONR Licensing and Regulation of a Geological Disposal Facility in the UK

    International Nuclear Information System (INIS)

    Boydon, Frans; Glazbrook, David

    2014-01-01

    Document available in abstract form only. Full text follows: The UK has substantial quantities of waste which has arisen from operation and decommissioning of legacy nuclear plant. While a disposal route for Low Level Waste (LLW) has been in operation in the UK for many years, there is as yet no such route for Higher Activity Waste. The government invited local communities to express an interest in hosting a Geological Disposal Facility (GDF). However, the Scottish government is opposed to deep disposal and proposes long-term interim storage in Scotland. This paper describes the work underway and current progress in developing a GDF for the UK. In particular it describes the current legal system in the UK that enables nuclear facilities to be licensed and the background underpinning licensing of existing disposal facilities. It identifies changes which will be necessary to legislation to enable a GDF to be licensed and work which it is performing in close co-operation with the Environment Agency which operate a permitting regime for environmental aspects. The Office of Nuclear Regulation (ONR) regulates safety, security and transport associated with nuclear sites. This paper focuses on the regulation of safety and radioactive waste. The UK licensing regime is non-prescriptive and proportionate, allowing for a flexible approach to licensing. The licence is not time-limited but is designed to be used from construction, through commissioning for the lifetime of the facility. Under the Nuclear Installations Act 1965 (as amended) ONR may attach licence conditions: - In the interests of safety; or - with respect to the handling, treatment and disposal of nuclear matter. ONR has developed a suite of 36 Licence conditions, which typically require the operator to made 'adequate arrangements' to ensure safety. These arrangements would involve the use of 'hold points' beyond which the operator must not proceed without ONR's agreement. In determining

  8. 12th Air Force > Home

    Science.gov (United States)

    Force AOR Travel Info News prevnext Slide show 76,410 pounds of food delivered to Haiti 12th Air Force the French Air Force, Colombian Air Force, Pakistan Air Force, Belgian Air Force, Brazilian Air Force

  9. Procédés de production d'aliments non conventionnels pour porcs à ...

    African Journals Online (AJOL)

    SARAH

    30 juil. 2013 ... CFA, va créer un manque à gagner de 12 à 13 millions de F CFA sur ... mise au point de tels procédés permettrait de créer de la valeur ajoutée ..... Comparaison participatoire de trois méthodes .... chevaux, poissons. Ouvrage ...

  10. Time Series Modelling using Proc Varmax

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2007-01-01

    In this paper it will be demonstrated how various time series problems could be met using Proc Varmax. The procedure is rather new and hence new features like cointegration, testing for Granger causality are included, but it also means that more traditional ARIMA modelling as outlined by Box...

  11. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C

    DEFF Research Database (Denmark)

    Nielsen, Mette J.; Veidal, Sanne S.; Karsdal, Morten A.

    2015-01-01

    -year. Patients were stratified according to Ishak stages 2-4. Internal cross-validation was performed by bootstrap analysis. RESULTS: Pro-C3 levels were significantly higher in CHC patients in Ishak stage 4 compared to stage 2 (P P ... (stage 4) from mild fibrosis (stage 2/3) (AUC = 0.72, P P = 0.007) levels was observed between the groups of -1, 0, +1 and +2 change in Ishak stage at 12 months. Pro-C3 was significantly increased in group +1 (P = 0.030) and +2 (P = 0...

  12. C5a regulates IL-12+ DC migration to induce pathogenic Th1 and Th17 cells in sepsis.

    Directory of Open Access Journals (Sweden)

    Ning Ma

    Full Text Available OBJECTIVE: It is well known that complement system C5a is excessively activated during the onset of sepsis. However, it is unclear whether C5a can regulate dentritic cells (DCs to stimulate adaptive immune cells such as Th1 and Th17 in sepsis. METHODS: Sepsis was induced by cecal ligation and puncture (CLP. CLP-induced sepsis was treated with anti-C5a or IL-12. IL-12(+DC, IFNγ(+Th1, and IL-17(+Th17 cells were analyzed by flow cytometry. IL-12 was measured by ELISA. RESULTS: Our studies here showed that C5a induced IL-12(+DC cell migration from the peritoneal cavity to peripheral blood and lymph nodes. Furthermore, IL-12(+DC cells induced the expansion of pathogenic IFNγ(+Th1 and IL-17(+Th17 cells in peripheral blood and lymph nodes. Moreover, IL-12, secreted by DC cells in the peritoneal cavity, is an important factor that prevents the development of sepsis. CONCLUSION: Our data suggests that C5a regulates IL-12(+DC cell migration to induce pathogenic Th1 and Th17 cells in sepsis.

  13. 12th Annual Report to Parliament

    International Development Research Centre (IDRC) Digital Library (Canada)

    leonardi

    INTRODUCTION. La Loi sur l'accès à l'information donne aux Canadiens ainsi qu'aux personnes et aux sociétés qui se trouvent au Canada le droit d'accéder aux documents du gouvernement fédéral qui ne contiennent pas de renseignements personnels. La. Loi complète les autres procédures d'obtention des ...

  14. Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12.

    Science.gov (United States)

    Komai-Koma, Mousa; Wang, Eryi; Kurowska-Stolarska, Mariola; Li, Dong; McSharry, Charles; Xu, Damo

    2016-03-01

    The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4(+) T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote human Th1 cell differentiation and how IL-33 polarizes Th1 cells is less understood. We assessed the ability of IL-33 to induce Th1 cell differentiation and IFN-γ production in vitro and in vivo. We report here that IL-33 alone had no ability in Th1 cell polarization. However it potentiated IL-12-mediated Th1 cell differentiation and IFN-γ production in TCR-stimulated murine and human CD4(+) T cells in vitro and in vivo. IL-33 promoted Th1 cell development via MyD88 and synergized with IL-12 to enhance St2 and IL-12R expression in CD4(+) T cells. These data therefore provide a novel mechanism for Th1 cell differentiation and optimal induction of a Type 1 response. Thus, IL-33 is capable of inducing IL-12-dependent Th1 cell differentiation in human and mouse CD4(+) T cells. Copyright © 2015 The Authors. Published by Elsevier GmbH.. All rights reserved.

  15. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy"....

  16. STUDY OF GEOGRAPHY TEXTBOOKS FOR 9th, 10th, 11th AND 12th GRADES. CASE STUDY: MAHARASHTRA STATE, INDIA

    Directory of Open Access Journals (Sweden)

    MARIANA-DOINA CÎINEANU

    2017-02-01

    Full Text Available The introduction conveys some data on learning in India and on designing Geography textbooks in this country. The present paper is reliant on four Geography textbooks, ranging from the 9th to the 12th grade. As regards each textbook, the study considers their learning units, then analyses their structure, the unitary way of designing them, the components of the panels of authors, the texts, illustrative materials, drills, learning activities, language, the wealth of Geography lexis, and the glossary.

  17. Probabilistic Reverse dOsimetry Estimating Exposure Distribution (PROcEED)

    Science.gov (United States)

    PROcEED is a web-based application used to conduct probabilistic reverse dosimetry calculations.The tool is used for estimating a distribution of exposure concentrations likely to have produced biomarker concentrations measured in a population.

  18. 12th Advanced Accelerator Concept (AAC 2006) Workshop

    International Nuclear Information System (INIS)

    Piot, Philippe

    2006-01-01

    Summary of the 12th Advanced Accelerator Concept (AAC 2006) Workshop help by NIU and ANL on July 10th-15th 2006 in Lake Geneva WI. The proceedings of the workshop have been published as an AIP conference proceedings '12th Advanced Accelerator Concepts Workshop' volume 877. The Twelfth Workshop on Advanced Accelerator Concepts was held at the Grand Geneva Resort in Lake Geneva, Wisconsin, from July 10 to July 15, 2006. The Workshop was sponsored by the High Energy Physics program of the U.S. Department of Energy, and was hosted by the Argonne Wakefield Accelerator Group (AWA) of Argonne National Laboratory and by Northern Illinois University. The workshop is a bi-annual meeting among physicist working on novel charged particle acceleration concept. The name 'advanced accelerator' physics covers long term research and development in beam physics and accelerator technologies. Some of the topics in advanced accelerator R and D are laser acceleration of electrons, wake field acceleration, novel high power rf source, new beam diagnostics, free-electron lasers, generating high brightness electron beams etc. The Advanced Accelerator Concept workshop is the only acknowledged and fully sponsored forum that provides a platform for inter- and cross-disciplinary discussion on various aspects of advanced accelerator and beam physics/technology concepts.

  19. High pressure synthesis of ThB/sub 12/ and HfB/sub 12/

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, J F; Farnsworth, P B [Brigham Young Univ., Provo, UT (USA). Dept. of Chemistry

    1938-08-01

    High pressure synthesis techniques were used to prepare ThB/sub 12/ and HfB/sub 12/. These compounds have the cubic UB/sub 12/-type structure with lattice parameters 7.612(1) A and 7.377(2) A respectively. The relationship between the lattice parameter for UB/sub 12/-type dodecaborides and the coordination number 12 radius of the metal atom differs for lanthanide, actinide and transition metal atoms. The prediction is made that it is possible to prepare AmB/sub 12/ at high pressures.

  20. Evaluation of pro-c global for identification of defects in protein c/s anticoagulant pathway

    International Nuclear Information System (INIS)

    Hanif, T.B.; Anwar, J.; Idrees, M.

    2011-01-01

    Background: Detection of protein C and S deficiency forms a major investigation in the laboratory evaluation of thrombophilia screening. It has key role in the diagnosis of protein C and S deficiency. The objective of this study is to determine the utility of ProC Global as a screening test for identifying the defects of protein C and S anticoagulant pathways. Methods: Two Hundred patients with venous thromboembolism were studied at the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, from October 2004 to March 2006. ProC Global test (Dade Behring Diagnostics) was performed and was followed up by protein C and S assays. ProC Global is an activated partial thromboplastin time based assay in which Protac (snake venom from Aghistroden contortrix) is used for activation of the endogenous protein C of the plasma sample. The protein C activation time in the presence of the activator was set in relation to a parallel determination of PCAT/O with addition of a buffer instead of activator reagent. The ratio PCAT: PCAT/O was transformed in normalized ratio by relating them to a calibrator. Control plasma for normal range and ProC control plasma for pathological range (Dade Behring Diagnostics) were assayed in each run for quality control. Results: A total of 200 patients, 132 (66%) males and 68 (34%) females with age ranging from 1 to 68 years were studied. ProC Global was positive in 29/200 (14.5%) patients. ProC Global was found to be 86% sensitive, 94% specific and its overall efficiency turned out to be 94%. Conclusion: Pro-C Global can be used effectively as a screening test to detect abnormalities in protein C and S anticoagulant pathways. (author)

  1. 12th International Symposium Continuous Surface Mining

    CERN Document Server

    2015-01-01

    This edited volume contains research results presented at the 12th International Symposium Continuous Surface Mining, ISCSM Aachen 2014. The target audience primarily comprises researchers in the lignite mining industry and practitioners in this field but the book may also be beneficial for graduate students.

  2. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit"....

  3. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance"....

  4. Towards an Operational Urban Modeling System for CBRN Emergency Response and Preparedness

    Science.gov (United States)

    2014-05-01

    urban sites, Proc, 7th International Conference of Urban Climate, 29 June- 3 July, Yokohama, Japon , A12-3 . Bélair, S., M. Abrahamowicz, S. Leroyer...conditions for the Montreal Urban Snow Experiment (MUSE) 2005, Proc, 7th International Conference of Urban Climate, 29 June- 3 July, Yokohama, Japon , A12-6...International Conference of Urban Climate, 29 June- 3 July, Yokohama, Japon , A12-5 . Leroyer, S., J. Mailhot, S. Bélair, A. Lemonsu and I. B. Strachan

  5. 12th International Conference on Computing and Information Technology

    CERN Document Server

    Boonkrong, Sirapat; Unger, Herwig

    2016-01-01

    This proceedings book presents recent research work and results in the area of communication and information technologies. The chapters of this book contain the main, well-selected and reviewed contributions of scientists who met at the 12th International Conference on Computing and Information Technology (IC2IT) held during 7th - 8th July 2016 in Khon Kaen, Thailand The book is divided into three parts: “User Centric Data Mining and Text Processing”, “Data Mining Algoritms and their Applications” and “Optimization of Complex Networks”.

  6. 12th Portuguese Conference on Automatic Control

    CERN Document Server

    Soares, Filomena; Moreira, António

    2017-01-01

    The biennial CONTROLO conferences are the main events promoted by The CONTROLO 2016 – 12th Portuguese Conference on Automatic Control, Guimarães, Portugal, September 14th to 16th, was organized by Algoritmi, School of Engineering, University of Minho, in partnership with INESC TEC, and promoted by the Portuguese Association for Automatic Control – APCA, national member organization of the International Federation of Automatic Control – IFAC. The seventy-five papers published in this volume cover a wide range of topics. Thirty-one of them, of a more theoretical nature, are distributed among the first five parts: Control Theory; Optimal and Predictive Control; Fuzzy, Neural and Genetic Control; Modeling and Identification; Sensing and Estimation. The papers go from cutting-edge theoretical research to innovative control applications and show expressively how Automatic Control can be used to increase the well being of people. .

  7. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage"....

  8. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies"....

  9. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement"....

  10. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 24 + 25 +26 + 27 + 28 +29 + 30 from track "Building Performance".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 24 + 25 +26 + 27 + 28 +29 + 30 from track "Building Performance"....

  11. 12th Anglo-French Physical Acoustics Conference (AFPAC2013)

    Science.gov (United States)

    2014-04-01

    The Anglo-French Physical Acoustics Conference (AFPAC) had its 12th annual meeting in Villa Clythia, Fréjus, France, from 16th to 18th January 2013. This series of meetings is a collaboration between the Physical Acoustics Group (PAG) of the Institute of Physics and the Groupe d'Acoustique Physique, Sous-marine et UltraSonore (GAPSUS) of the Société Française d'Acoustique. This year, attendees got the opportunity to see the French Riviera with its Mediterranean vegetation covered by a nice thick snow layer. The participants heard 34 excellent oral presentations and saw 3 posters covering an exciting and diverse range of subjects and of frequencies, from ultrasonic wave propagation in chocolate to metamaterials applied to seismic waves for protecting buildings. Among them, invited talks were given by Pr F A Duck ( Enhanced healing by ultrasound: clinical effects and mechanisms), Pr. J-C Valiére, who actually gave two invited talks ( 1. Measurement of audible acoustic particle velocity using laser: Principles, signal processing and applications, 2. Acoustic pots in ancient and medieval buildings: Literary analysis of ancient texts and comparison with recent observations in French churches), Dr P Huthwaite ( Ultrasonic imaging through the resolution of inverse problems), Dr X Lurton ( Underwater acoustic systems on oceanographic research vessels: principles and applications), Dr S Guenneau ( From platonics to seismic metamaterials). For the fifth consecutive year AFPAC is followed by the publication of its proceedings with 12 peer-reviewed papers which cover the most recent research developments in the field of Physical Acoustics in the UK and France. Alain Lhémery (CEA, France) and Nader Saffari (UCL, United Kingdom) French Riviera 12th AFPAC — Villa Clythia, Fréjus (French Riviera), the 17th of January 2013

  12. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 17 + 18 + 19 + 20 +21 + 22 + 23 from track "Ventilation & Air Distribution".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 17 + 18 + 19 + 20 +21 + 22 + 23 from track "Ventilation & Air Distribution"....

  13. 12th International Symposium on Cosmology and Particle Astrophysics

    CERN Document Server

    Choi, Kiwoon; Kim, San Pyo

    2016-01-01

    CosPA 2015 is the 12th Asia-Pacific Symposium on Cosmology and Particle Astrophysics. It will be held from the 12-16 October 2015 at the Center for Theoretical Physics of the Universe (CTPU) of Institute for Basic Science (IBS), located at the KAIST Munji Campus in Daejeon City.

  14. Contributions to the 12th. International Cryogenic Engineering Conference

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The report consists of two papers read at the 12 th International Cryogenic Engineering Conference Held in Southampton from 12 to 15 July 1988. The first deals with the design of a conductor for NET machine; the second one gives the description of the liquid Nitrogen cooling system of the FTU tokamak

  15. Radiolabelled Interleukin-12, a new radiopharmaceutical for imaging chronic TH1-mediated inflammation

    International Nuclear Information System (INIS)

    Annovazzi, A.; Cornelissen, B.; Slegers, G.; D'Alessandria, C.; Bonanno, E.; Signore, A.

    2003-01-01

    Full text: Cytokines have been extensively used to image inflammatory processes (IL1, IL2, IL6, IL8 and others). In particular, for chronic inflammation, labelled IL2 has been successfully used although it binds to both T helper-1 (Th1) and T helper-2 (Th2) cells. In order to increase the specificity for the detection of Th1-mediated inflammation (i.e. organ specific autoimmune diseases), we considered the possibility to label the interleukin-12 (IL12), an heterodimeric cytokine which play a key role in the development of Th1 cells. Objectives: Aim of the present study was to label the Interleukin-12 with 123I and to test its potential as radiopharmaceutical to image chronic inflammatory disorders. Methods: IL12 was labelled with 123I using the IODOGEN method and purified by gel-filtration chromatography on PD10 columns. 123I-IL12 biodistribution was studied in normal NMRI mice at 1,2 and 4h after injection. A mouse model of autoimmune chronic colitis induced by intrarectal instillation of Trinitrobenzen sulfonic acid (TNBS) has been used for imaging purposes and, as controls, mice receiving 50% ethanol in phosphate buffer saline. Results: 123I-IL12 labelling efficiency ranged between 52-65%. Results of biodistribution studies showed a rapid plasma clearance and a main renal excretion route. No significant 123I-IL12 accumulation in major organs and tissues was observed. 123I-IL12 accumulated in areas of chronic inflamed colon as assessed by histological examination. No significant 123I-IL12 uptake is detectable in mice with acute colitis, confirming the specificity of 123IIL12 binding on its receptors expressed on T-lymphocytes. Conclusions: We conclude that this cytokine could be used for the in vivo imaging of Th1 mediated inflammatory processes. (author)

  16. Un procédé de validation des métamodèles par les métadonnées

    OpenAIRE

    Plantec , Alain; Ribaud , Vincent

    2005-01-01

    International audience; La norme STEP a pour objet de standardiser des modèles de données par métier. Ce standard a développé un procédé de validation de la conformité des modèles dans lequel l'instanciation est un composant essentiel : un modèle est valide si un ensemble d'instances conformes au modèle est jugé sémantiquement correct par un expert du domaine. Appliqué à la métamodélisation, cette approche permet de construire et de valider les métamodèles par ranements successifs. Cette méth...

  17. International Geomagnetic Reference Field: the 12th generation

    DEFF Research Database (Denmark)

    Thébault, Erwan; Finlay, Chris; Beggan, Ciarán D.

    2015-01-01

    The 12th generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2014 by the Working Group V-MOD appointed by the International Association of Geomagnetism and Aeronomy (IAGA). It updates the previous IGRF generation with a definitive main field model for epoch ...

  18. Using SAS PROC MCMC for Item Response Theory Models

    Science.gov (United States)

    Ames, Allison J.; Samonte, Kelli

    2015-01-01

    Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian…

  19. Counterbalancing of TH2-driven allergic airway inflammation by IL-12 does not require IL-10.

    Science.gov (United States)

    Tournoy, K G; Kips, J C; Pauwels, R A

    2001-03-01

    Asthma is characterized by allergen-induced airway inflammation orchestrated by TH2 cells. The TH1-promoting cytokine IL-12 is capable of inhibiting the TH2-driven allergen-induced airway changes in mice and is therefore regarded as an interesting strategy for treating asthma. The antiallergic effects of IL-12 are only partially dependent of IFN-gamma. Because IL-12 is a potent inducer of the anti-inflammatory cytokine IL-10, the aim of the present study was to investigate in vivo whether the antiallergic effects of IL-12 are mediated through IL-10. C57BL/6J-IL-10 knock-out (IL-10(-/-)) mice were sensitized intraperitoneally to ovalbumin (OVA) and subsequently exposed from day 14 to day 21 to aerosolized OVA (1%). IL-12 was administered intraperitoneally during sensitization, subsequent OVA exposure, or both. IL-12 inhibited the OVA-induced airway eosinophilia, despite the absence of IL-10. Moreover, a shift from a TH2 inflammatory pattern toward a TH1 reaction was observed, with concomitant pronounced mononuclear peribronchial inflammation after IL-12 treatment. Allergen-specific IgE synthesis was completely suppressed only when IL-12 was administered along with the allergen sensitization. Furthermore, treating the animals with IL-12 at the time of the secondary allergen challenge resulted not only in a significant suppression of the airway responsiveness but also in an important IFN-gamma-associated toxicity. These results indicate that IL-12 is able to inhibit allergen-induced airway changes, even in the absence of IL-10. In addition, our results raise concerns regarding the redirection of TH2 inflammation by TH1-inducing therapies because treatment with IL-12 resulted not only in a disappearance of the TH2 inflammation but also in a TH1-driven inflammatory pulmonary pathology.

  20. Power generation in the 12-th five-year plan

    International Nuclear Information System (INIS)

    Troitskij, A.A.

    1986-01-01

    The state of electric power generation in the 11-th five-year plan is summed up. Perspectives of development of heat and electric power generation in the 12-th five-year plan are considered. Thermal power generation of NPPs in 1990 will increase by a factor of 8.4 as compared with 1975. The NPP development will be mainly realized on the basis of the WWER-1000 type reactors. It is planned to commission fast reactors of up to 800 MW

  1. 12th International Conference on Intelligent Autonomous Systems (IAS-12)

    CERN Document Server

    Yoon, Kwang-Joon; Lee, Jangmyung; Frontiers of Intelligent Autonomous Systems

    2013-01-01

    This carefully edited volume aims at providing readers with the most recent progress on intelligent autonomous systems, with its particular emphasis on intelligent autonomous ground, aerial and underwater vehicles as well as service robots for home and healthcare under the context of the aforementioned convergence. “Frontiers of Intelligent Autonomous Systems” includes thoroughly revised and extended papers selected from the 12th International Conference on Intelligent Autonomous Systems (IAS-12), held in Jeju, Korea, June 26-29, 2012. The editors chose 35 papers out of the 202 papers presented at IAS-12 which are organized into three chapters: Chapter 1 is dedicated to autonomous navigation and mobile manipulation, Chapter 2 to unmanned aerial and underwater vehicles and Chapter 3 to service robots for home and healthcare. To help the readers to easily access this volume, each chapter starts with a chapter summary introduced by one of the editors: Chapter 1 by Sukhan Lee, Chapter 2 by Kwang Joon Yoon and...

  2. Network Level Association and Fusion of Kinematic and Attribute Information

    Science.gov (United States)

    2010-12-15

    L. Svensson, ``More Ways to Track Closely-Spaced Targets Than You Wanted To Know or Tips For Not Pissing Off the Radar Operator So Much That He Turns...To Know or Tips For Not Pissing Off the Radar Operator So Much That He Turns Off the Track Display”, Proc. ONR-GTRI Workshop on Tracking, Santa Barbara

  3. pROC: an open-source package for R and S+ to analyze and compare ROC curves.

    Science.gov (United States)

    Robin, Xavier; Turck, Natacha; Hainard, Alexandre; Tiberti, Natalia; Lisacek, Frédérique; Sanchez, Jean-Charles; Müller, Markus

    2011-03-17

    Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often reached through inconsistent use or insufficient statistical analysis. To support researchers in their ROC curves analysis we developed pROC, a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface. With data previously imported into the R or S+ environment, the pROC package builds ROC curves and includes functions for computing confidence intervals, statistical tests for comparing total or partial area under the curve or the operating points of different classifiers, and methods for smoothing ROC curves. Intermediary and final results are visualised in user-friendly interfaces. A case study based on published clinical and biomarker data shows how to perform a typical ROC analysis with pROC. pROC is a package for R and S+ specifically dedicated to ROC analysis. It proposes multiple statistical tests to compare ROC curves, and in particular partial areas under the curve, allowing proper ROC interpretation. pROC is available in two versions: in the R programming language or with a graphical user interface in the S+ statistical software. It is accessible at http://expasy.org/tools/pROC/ under the GNU General Public License. It is also distributed through the CRAN and CSAN public repositories, facilitating its installation.

  4. Notarial acts «ad pedes consulum». About some Milanese trial records (12th-13th Century

    Directory of Open Access Journals (Sweden)

    Marta Luigina Mangini

    2014-06-01

    Full Text Available Milan’s documentary heritage created between the 12th and the 13th century is to be found by searching the records of the administrative offices and religious institutions that regularly had dealings with it. The aim of this paper is to examine some of these records anew, particularly evaluating the evolution of the constants and variables that have strongly influenced their creation and preservation over time.

  5. 12th Biennial International Conference on Baroque Music

    Czech Academy of Sciences Publication Activity Database

    Jonášová, Milada; Kapsa, Václav; Maňourová, L.

    2007-01-01

    Roč. 44, č. 1 (2007), s. 91-93 ISSN 0018-7003. [12th Biennial International Conference on Baroque Music . Varšava, 26.07.2006-30.07.2006] R&D Projects: GA AV ČR KJB800580502 Institutional research plan: CEZ:AV0Z90580513 Keywords : music * conference * baroque Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. 12th International Symposium on Open Collaboration Companion

    CERN Document Server

    2016-01-01

    Welcome to the proceedings of OpenSym 2016, the 12th international symposium on open collaboration! Open collaboration is collaboration that is egalitarian (everyone can join, no principled or artificial barriers to participation exist), meritocratic (decisions and status are merit-based rather than imposed) and self-organizing (processes adapt to people rather than people adapt to predefined processes).

  7. Prompt Neutron Spectrometry for Identification of SNM in Unknown Shielding Configurations: FY16 ONR YIP Final Report

    Science.gov (United States)

    2016-05-31

    disciplines, including linear algebra , computer science, computational statistics, Bayesian inference, information theory, and machine learning. The...condition number (borrowed from linear algebraic concepts) of a proposed instrument’s response matrix, for example, was recognized and repurposed as...shoulders of the ONR subsidized SeaPerch program, outreach activities for elementary aged schoolchildren, in the form of underwater robotics, impacted more

  8. Wooden Supports in 12th–16th-Century European Paintings

    DEFF Research Database (Denmark)

    2016-01-01

    Jacqueline Marette's Connaissance des primitifs par l'étude du bois du XIIe au XVIe siècle' (1961) is a unique resource on the history of painting techniques that combines scholarship in art history, conservation, and wood science. With support from the Getty Foundation's Panel Paintings Initiati...... features critical readings of the original texts and updated references, as well as commentary from specialists with technical expertise and art-historical knowledge on northern European panel paintings from the 12th to the 16th centuries....

  9. IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.

    Directory of Open Access Journals (Sweden)

    Stephanie M Coomes

    2015-07-01

    Full Text Available Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the chronicity of infection. Immunity to Plasmodium or helminths requires divergent CD4+ T cell-driven responses, dominated by IFNγ or IL-4, respectively. Recent literature has indicated that Th cells, including Th2 cells, have phenotypic plasticity with the ability to produce non-lineage associated cytokines. Whether such plasticity occurs during co-infection is unclear. In this study, we observed reduced anti-helminth Th2 cell responses and compromised anti-helminth immunity during Heligmosomoides polygyrus and Plasmodium chabaudi co-infection. Using newly established triple cytokine reporter mice (Il4gfpIfngyfpIl17aFP635, we demonstrated that Il4gfp+ Th2 cells purified from in vitro cultures or isolated ex vivo from helminth-infected mice up-regulated IFNγ following adoptive transfer into Rag1-/- mice infected with P. chabaudi. Functionally, Th2 cells that up-regulated IFNγ were transcriptionally re-wired and protected recipient mice from high parasitemia. Mechanistically, TCR stimulation and responsiveness to IL-12 and IFNγ, but not type I IFN, was required for optimal IFNγ production by Th2 cells. Finally, blockade of IL-12 and IFNγ during co-infection partially preserved anti-helminth Th2 responses. In summary, this study demonstrates that Th2 cells retain substantial plasticity with the ability to produce IFNγ during Plasmodium infection. Consequently, co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing anti-helminth Th2 cells and converting them into IFNγ-secreting cells.

  10. Special Issue the 12th International Conference on Substorms

    Science.gov (United States)

    Shiokawa, Kazuo; Fok, Mei-Ching; Fujimoto, Masaki

    2016-01-01

    The 12th International Conference on Substorms (ICS-12) was held at the Ise-Shima Royal Hotel in Shima, Japan, on November 10-14, 2014. There were 125 attendees including 68 from foreign countries. The ICS has been held every 2 years since 1992 to discuss substorms, which are fundamental global-scale disturbances in the Earth's magnetosphere. The year 2014 marked the 50th anniversary of the first publication about substorms (Akasofu 1964). The conference included three tutorial lecturers (Profs. S.-I. Akasofu, V. Angelopoulous, and D. Baker), as well as many international scientists, to discuss substorm processes in the tail, their Interactions with the inner magnetosphere and the ionosphere, substorm currents and their dynamics and energetics, the role of MagnetoHydroDynamics (MHD) and kinetic instabilities, storm-substorm relationships, ULFELFVLF waves, and non-Earth substorm-like features. Prof. Akasofu also gave an evening talk about the history of auroral research since the nineteenth century with photographs that inspired and intrigued the young scientists and students in attendance.

  11. Preface to Proceedings of the 12th European Workshop on Natural Language Generation (ENLG 2009)

    NARCIS (Netherlands)

    Krahmer, E.; Krahmer, E.; Theune, Mariet

    We are pleased to present the Proceedings of the 12th European Workshop on Natural Language Generation (ENLG 2009). ENLG 2009 was held in Athens, Greece, as a workshop at the 12th Conference of the European Chapter of the Association for Computational Linguistics (EACL 2009). Following our call, we

  12. [Comparison of screw' inserting angle through the 11th and 12th rib anterior approaches for L1 burst fracture].

    Science.gov (United States)

    Ma, Li-Tai; Liu, Hao; Li, Tao; Song, Yue-Ming; Pei, Fu-Xing; Liu, Li-Min; Gong, Quan; Zeng, Jian-Cheng; Feng, Gan-Jun; Zhou, Zhong-Jie

    2012-12-01

    To compare screw's inserting angle through the 11th and 12th rib in treating L1 burst fracture, explore effects on inserting screw and postoperative angle. From October 2007 to October 2010, 108 patients with L1 brust fracture treated through anterior approach were analyzed,including 68 males and 40 females, aged from 21 to 64 years (mean 38.22 years). All patients were divided into the 11th (A, 51 cases) and 12th (B, 57 cases) approach. The data of operation time,blood loss, duration of incision pain, JOA score, Oswestry score, VAS score, quality of life (SF-36), recovery of nervous function, coronal Cobb angle, included angle between screw and plate were observed. All patients were followed up for 9 to 37 months, mean 23 months. The operation time, blood loss, duration of incision pain, in group A were lower than group B (P0.05). There were no differences in Cobb angle before operation, but had significance after operation (P=0.000). There were statistically significance between two group in angle between screw and plate (P=0.000, P=0.003). The 11th rib approach for the treatment of L1 burst fracture has less effects on screw, less trauma and less angle between screw and plate.

  13. CLIMA 2016 - proceedings of the 12th REHVA World Congress:volume 3

    OpenAIRE

    2016-01-01

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings.This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".

  14. ONR Far East Scientific Bulletin, Volume 12, Number 4, October-December 1987,

    Science.gov (United States)

    1987-12-01

    magnetic Japan Control Engineers Measurements (CPEM󈨜) 1-35-28-303 Hongo , Bunkyo-ku, Tokyo 113 June The 7th International Kyoto, Professor Isao Yamada...Physics-Material Japan Faculty of Engineering, 0 Research Society) Inter- Tokyo University national Conference on 7-3-1 Hongo , Bunkyo-ku, Tokyo 113...o Department of Psychological 39-FlOO-J200 Chemistry and Nutrition, Faculty of Medicine, University of Tokyo 7-3-1 Hongo , Bunkyo-ku, Tokyo 113

  15. Mental and somatic health complaints associated with school bullying between 10th and 12th grade students; results from cross sectional studies in Oslo, Norway.

    Science.gov (United States)

    Lien, Lars; Green, Kristian; Welander-Vatn, Audun; Bjertness, Espen

    2009-03-23

    Bullying is a widespread and serious problem that might influence both mental and psychical well being as well as school performance and social life. The aim of this study was to describe the prevalence of bullying, mental health problems and psychical complaints among 10th and 12th grade students and to analyze the association between bullying, mental health problems and muscle and skeletal complaints. Two cross sectional studies of adolescents living in Oslo, Norway the first conducted in 2001 among 10th grade students (15/16 years old) and the second in 2004 among 12th grade students (18/19 years old). Both surveys were based on self report, were mostly school based and had almost identical questionnaires. There were around 3700 participants in both surveys, but the participation rate was lower in the latter survey (88 versus 80%). The Hopkins Symptoms Check List (HSCL-10) and the Strength and Difficulties Questionnaire (SDQ) were used to measure mental health problems. Bullying is decreasing both among boys and girls while the prevalence of internalized mental health problems are increasing from 10th to 12th grade. For muscle and skeletal pain there is a diverging trend between boys and girls, with an increase among girls and a decrease among boys. The highest Odds Ratios, as a measure for the association between bullying, mental health problems and pain, were found for internalized mental health problems at both 10th and 12th grade both for boys and girls. Both internalized and externalized mental health problems together with pain seem to be associated with bullying irrespective of school type and gender.

  16. Self-reported reasons for vaping among 8th, 10th, and 12th graders in the US: Nationally-representative results.

    Science.gov (United States)

    Patrick, Megan E; Miech, Richard A; Carlier, Carola; O'Malley, Patrick M; Johnston, Lloyd D; Schulenberg, John E

    2016-08-01

    The study describes the most common reasons for using vaporizers (such as e-cigarettes) among US adolescents and investigates how reasons for use differ by grade, lifetime cigarette use, frequency of vaporizer use, gender, race/ethnicity, and parent education. Data were collected from 4066 students in the 8th, 10th, and 12th grades in 2015 as part of the Monitoring the Future study, a cross-sectional and nationally representative US survey. Common reasons for vaporizer use reported by respondents who had ever used a vaporizer were experimentation (53.0%), taste (37.2%), boredom (23.5%), having a good time (22.4%), and relaxation (21.6%). Reasons differed little across grades or parent education; reasons differed by lifetime use of regular cigarettes, frequency of vaping, gender, and race/ethnicity. Overall, results suggest that decisions to vape are based on curiosity, taste, and pleasure, rather than for reasons such as quitting regular cigarettes or substituting for regular cigarette smoking. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 37 + 38 +39 + 40 from track "Heating and Cooling Systems" and the session number 41 from track...

  18. International Geomagnetic Reference Field: the 12th generation

    OpenAIRE

    Thébault , Erwan; Finlay , Christopher ,; Beggan , Ciarán ,; Alken , Patrick; Aubert , Julien ,; Barrois , Olivier; Bertrand , François; Bondar , Tatiana; Boness , Axel; Brocco , Laura; Canet , Elisabeth ,; Chambodut , Aude; Chulliat , Arnaud ,; Coïsson , Pierdavide ,; Civet , François

    2015-01-01

    International audience; The 12th generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2014 by the Working Group V-MOD appointed by the International Association of Geomagnetism and Aeronomy (IAGA). It updates the previous IGRF generation with a definitive main field model for epoch 2010.0, a main field model for epoch 2015.0, and a linear annual predictive secular variation model for 2015.0-2020.0. Here, we present the equations defining the IGRF model, p...

  19. Distributed Autonomous Robotic Systems : the 12th International Symposium

    CERN Document Server

    Cho, Young-Jo

    2016-01-01

    This volume of proceedings includes 32 original contributions presented at the 12th International Symposium on Distributed Autonomous Robotic Systems (DARS 2014), held in November 2014. The selected papers in this volume are authored by leading researchers from Asia, Europe, and the Americas, thereby providing a broad coverage and perspective of the state-of-the-art technologies, algorithms, system architectures, and applications in distributed robotic systems. .

  20. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains "Topical Sessions" from track listed here: IEA EBCAnnex 59 (session 1) IEA EBC Annex 61 (session 2) IEA EBC Annex 64...

  1. STEM development: A study of 6th--12th grade girls' interest and confidence in mathematics and science

    Science.gov (United States)

    Heaverlo, Carol Ann

    Researchers, policymakers, business, and industry have indicated that the United States will experience a shortage of professionals in the Science, Technology, Engineering, and Mathematics (STEM) fields. Several strategies have been suggested to address this shortage, one of which includes increasing the representation of girls and women in the STEM fields. In order to increase the representation of women in the STEM fields, it is important to understand the developmental factors that impact girls' interest and confidence in STEM academics and extracurricular programs. Research indicates that greater confidence leads to greater interest and vice versa (Denissen et al., 2007). This study identifies factors that impact girls' interest and confidence in mathematics and science, defined as girls' STEM development. Using Bronfenbrenner's (2005) bioecological model of human development, several factors were hypothesized as having an impact on girls' STEM development; specifically, the macrosystems of region of residence and race/ethnicity, and the microsystems of extracurricular STEM activities, family STEM influence, and math/science teacher influence. Hierarchical regression analysis results indicated that extracurricular STEM involvement and math teacher influence were statistically significant predictors for 6--12th grade girls' interest and confidence in mathematics. Furthermore, hierarchical regression analysis results indicated that the only significant predictor for 6--12th grade girls' interest and confidence in science was science teacher influence. This study provides new knowledge about the factors that impact girls' STEM development. Results can be used to inform and guide educators, administrators, and policy makers in developing programs and policy that support and encourage the STEM development of 6--12th grade girls.

  2. 12th international conference on human retrovirology: HTLV and related retroviruses

    Directory of Open Access Journals (Sweden)

    Lairmore Michael D

    2005-10-01

    Full Text Available Abstract The 12th International Conference on Human Retrovirology: HTLV and Related Retroviruses, was held at the Half Moon Hotel in Montego Bay, Jamaica, from June 22nd to June 25th 2005. The scientific conference, sponsored by the International Retrovirology Association, is held biennially at rotating international venues around the world. The meeting brings together basic scientists, epidemiologists and clinical researchers to discuss findings to prevent HTLV infection or develop new therapies against HTLV-mediated diseases. The Association fosters the education and training of young scientists to bring new approaches to the complex problems of HTLV research, such as translational research to bring findings from the laboratory into clinical trials that benefit HTLV-infected patients. The breadth and quality of research presentations and workshops at the 12th International Conference indicate that these goals are being accomplished. As HTLV research enters its third decade a new generation of scientists face many challenges. However, HTLV scientists and clinicians displayed exciting new approaches and discoveries during plenary talks and poster sessions. The conference encouraged research in HTLV infections and disease, fostered collaborations, and stimulated new partnerships between clinicians and scientists to encourage clinical trials and novel therapeutic interventions.

  3. Recombinant murine IL-12 promotes a protective Th1/cellular response in Mongolian gerbils infected with Sporothrix schenckii.

    Science.gov (United States)

    Flores-García, Aurelio; Velarde-Félix, Jesús Salvador; Garibaldi-Becerra, Vicente; Rangel-Villalobos, Héctor; Torres-Bugarín, Olivia; Zepeda-Carrillo, Eloy Alfonso; Ruíz-Bernés, Salvador; Ochoa-Ramírez, Luis Antonio

    2015-02-01

    Sporotrichosis is a cutaneous fungal infection caused by Sporothrix schenckii. It is known to be mainly contained by Th1 responses. As IL-12 is crucial for Th1 response, we investigated if treatment with recombinant murine IL-12 (rmIL-12) promoted Th1 immunity and/or clinical improvement in an experimental sporotrichosis gerbil model. Gerbils were inoculated with S. schenckii in the footpad and treated with rmIL-12. Seven days post infection there was a significant increase in macrophage phagocytosis and oxidative burst, and in delayed-type hypersensitivity (DTH) reaction in rmIL-12 treated gerbils, as well as a ∼10-fold increase of serum IFN-gamma and a decrease of IL-4 and IL-10. Moreover, rmIL-12 substantially decreased (∼70%) S. schenckii burden in liver and spleen and improved the clinical outcome preventing footpad ulcer and tail nodules observed in untreated gerbils. Our study demonstrates that rmIL-12 promotes Th1 immune response against S. schenckii favouring its clearance and preventing clinical symptoms.

  4. 12th International Conference on Thalassemia and the Haemoglobinopathies, 11-14 May 2011, Antalya, Turkey

    Directory of Open Access Journals (Sweden)

    Guest Editors: Aurelio Maggio, Duran Canatan, Androulla Eleftheriou

    2011-05-01

    Full Text Available This abstract book contains all abstracts presented to the 12th International Conference on Thalassaemia and Other Haemoglobinopathies, and the 14th TIF Conference for Patients and Parents, 11-14 May 2011, Antalya, Turkey.

  5. Mesures de procédure spéciales et respect des droits de l'homme Rapport général

    OpenAIRE

    Vervaele, J.A.E.

    2009-01-01

    Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le terrorisme et la criminalité organisée, et de voir si cela a conduit les pays à se départir de leur propres règles fondamentales, procédures, principes et standards des droits de l’homme applicables...

  6. Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis

    DEFF Research Database (Denmark)

    Leeming, Diana J; Veidal, Sanne S; Karsdal, Morten A

    2015-01-01

    Pro-C5 reflects liver hemodynamics, liver function, disease stage and clinically significant portal hypertension (PH). A multimarker model in combination with clinical scores predicted HVPG and separated clinical relevant HVPG thresholds. Plasma Pro-C5 may be suitable for the noninvasive evaluation...

  7. Energy education resources: Kindergarten through 12th grade

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Energy Education Resources: Kindergarten Through 12th Grade is published by the National Energy Information Center (NEIC) a service of the Energy Information Administration (EIA), to provide students, educators, and other information users, a list of generally available free or low-cost energy-related educational materials. Each entry includes the address, telephone number, and description of the organization and the energy-related materials available. Most of the entries also include Internet (Web) and electronic mail (E-Mail) addresses. Each entry is followed by a number, which is referenced in the subject index in the back of this book.

  8. 12TH SEPTEMBER REVOLUTION IN TURKISH NOVEL / TÜRK ROMANINDA 12 EYLÜL DARBESİ

    Directory of Open Access Journals (Sweden)

    Macit BALIK (M.A.H.

    2009-01-01

    Full Text Available Stendhal’s “the mirror hold up to the street” fact,which’s valid more than two hundred years, defines thevein of literature and life. This definition of novel evolvesto reflex innerworld in modernist period. Besides beingthe soul constitutive identity, literary work ofnationalities demonstrates very important signs fromsocial and politics way of life. Since administrativereforms Turkish literature has close contact to politics insome stages. Therefore, social and politics readingtendency can clearly be seen in literature analysis. Fromthe first generation of administrative reforms to therepublic period, many different kinds of literary worksabout the three military revolutions, collectivist realistictendency manner and about worker’s life that migrate toGermany, has been written. These mentioned periodscould be an indication to the fact that Turkish literatureis within the politics.The reflection of 12th September militaryrevolution seen clearly in novel is one of the periods inwhich the dose of politics in literature increased. AdaletAğaoğlu’s Hayır… (No…, Kaan Arslanoğlu’s Devrimciler(Revolutionaries, Mehmet Eroğlu’s Yüz: 1981 (Face:1981, Ahmet Altan’s Sudaki Đz (Trace in Water, OrhanPamuk’s Sessiz Ev (Silent House are among the fewnovels that reflect this period without engaging it to theideologies. This article is an attempt for contrastively andanalytically evaluation of the 12th September revolution’sreflections on Turkish Literature using above mentionedexamples.

  9. Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA.

    Science.gov (United States)

    Gröttrup, Bernd; May, Caroline; Meyer, Helmut E; Grinberg, Lea T; Park, Young Mok

    2013-01-01

    The HUPO Brain Proteome Project (HUPO BPP) held its 18(th) workshop in Boston, USA, September 12(th) 2012 during the HUPO 11th Annual Word Congress. The focus was on the progress on the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Data processing and analysis with the autoPROC toolbox

    Energy Technology Data Exchange (ETDEWEB)

    Vonrhein, Clemens, E-mail: vonrhein@globalphasing.com; Flensburg, Claus; Keller, Peter; Sharff, Andrew; Smart, Oliver; Paciorek, Wlodek; Womack, Thomas; Bricogne, Gérard [Global Phasing Ltd, Sheraton House, Castle Park, Cambridge CB3 0AX (United Kingdom)

    2011-04-01

    Typical topics and problems encountered during data processing of diffraction experiments are discussed and the tools provided in the autoPROC software are described. A typical diffraction experiment will generate many images and data sets from different crystals in a very short time. This creates a challenge for the high-throughput operation of modern synchrotron beamlines as well as for the subsequent data processing. Novice users in particular may feel overwhelmed by the tables, plots and numbers that the different data-processing programs and software packages present to them. Here, some of the more common problems that a user has to deal with when processing a set of images that will finally make up a processed data set are shown, concentrating on difficulties that may often show up during the first steps along the path of turning the experiment (i.e. data collection) into a model (i.e. interpreted electron density). Difficulties such as unexpected crystal forms, issues in crystal handling and suboptimal choices of data-collection strategies can often be dealt with, or at least diagnosed, by analysing specific data characteristics during processing. In the end, one wants to distinguish problems over which one has no immediate control once the experiment is finished from problems that can be remedied a posteriori. A new software package, autoPROC, is also presented that combines third-party processing programs with new tools and an automated workflow script that is intended to provide users with both guidance and insight into the offline processing of data affected by the difficulties mentioned above, with particular emphasis on the automated treatment of multi-sweep data sets collected on multi-axis goniostats.

  11. Operation and Maintenance of the Research Platform FLIP

    Science.gov (United States)

    2013-12-17

    by FLIP 2006 15Aug-11 Sept PI R. Pinkel, MPL , ONR, AESOP 02 Oct-04 Nov PI J. Hildebrand, MPL ONR Marine Mammal 2007 21 Feb-16Mar T. Golfinos ONR...Dry Dock in ARCO 30 Oct-29 Nov PIJ. Hildebrand, MPL ONR/N45 Marine Mammal 2008 03-25 Sep PI K. Melville, MPL ONR RaDyo Program 13 0ct-12Nov PI J...Hildebrand, MPL ONR Marine Mammal Research 2009 6-7 May PI K. Melville, MPL ONR Sea Trials 06-14 Jul PI K. Melville, MPL ONR ONR HiRes 03-13 Aug T

  12. Mesures de procédure spéciales et respect des droits de l'homme
    Rapport général

    OpenAIRE

    John A.E. Vervaele

    2009-01-01

    Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le terrorisme et la criminalité organisée, et de voir si cela a conduit les pays à se départir de leur propres règles fondamentales, procédures, principes et standards des droits de l’homme applicables...

  13. CLIMA 2016 - proceedings of the 12th REHVA World Congress:volume 6

    OpenAIRE

    2016-01-01

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 24 + 25 +26 + 27 + 28 +29 + 30 from track "Building Performance".

  14. Mesures de procédure spéciales et respect des droits de l'homme Rapport général

    NARCIS (Netherlands)

    Vervaele, J.A.E.

    2009-01-01

    Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le

  15. A possible case of Garre's sclerosing osteomyelitis from Medieval Tuscany (11th-12th centuries).

    Science.gov (United States)

    Giuffra, Valentina; Vitiello, Angelica; Giusiani, Sara; Caramella, Davide; Fornaciari, Gino

    2015-12-01

    Archaeological excavations carried out at the castle of Monte di Croce near Florence brought to light a small cemetery complex belonging to the castle church, dated back to the 11th-12th centuries. An elite stone tomb contained the skeletal remains of a male aged 35-45 years with obvious pathology of the right tibia. The proximal metaphysis and the upper half of the diaphysis appear massively enlarged as a result of severe chronic periostitis. A transverse section illustrates complete obliteration of the medullary cavity by new spongy bone, with some large cavitations. The primary, but completely remodeled tibial shaft is still recognizable. This finding and the strong sclerotic reaction with some central cavitations rule out any form of bone tumor and indicate a chronic inflammatory disease. The morphological and radiological picture and the tibial localization suggest a diagnosis of chronic sclerosing osteomyelitis of Garré, a rare form of chronic osteomyelitis characterized by an intense periosteal reaction with little or no suppuration. Copyright © 2015. Published by Elsevier Inc.

  16. PREFACE: 12th High-Tech Plasma Processes Conference (HTPP-12)

    Science.gov (United States)

    Gleizes, Alain; Ghedini, Emanuele; Gherardi, Matteo; Sanibondi, Paolo; Dilecce, Giorgio

    2012-12-01

    The High-Tech Plasma Processes - 12th European Plasma Conference (HTPP-12) was held in Bologna (Italy) on 24-29 June 2012. The conference series started in 1990 as a thermal plasma conference and gradually expanded to include other topic fields as well. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. Thanks to the efforts of the conference chairman, Professor Vittorio Colombo and of the co-chair, Professor Piero Favia, a well balanced participation from both the communities of thermal and nonthermal plasma researchers was achieved; this resulted in just about 196 attendees from 39 countries, with 8 plenary and 15 invited talks, plus 50 oral and 140 poster contributions. This volume of Journal of Physics: Conference Series gathers papers from regular contributions of HTPP-12; each contribution submitted for publication has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In the end, 39 manuscripts were accepted for publication, covering different topics of plasma processing science: from plasma fundamentals and modelling to source design and process diagnostics, from nanomaterial synthesis to surface modification, from waste treatment to plasma applications in a liquid environment. It is an honour to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local

  17. 11th International Conference on Multimedia and Ubiquitous Engineering & 12th International Conference on Future Information Technology

    CERN Document Server

    Chen, Shu-Ching; Choo, Kim-Kwang

    2017-01-01

    This book presents the proceedings of the 11th International Conference on Multimedia and Ubiquitous Engineering (MUE2017) and the 12th International Conference on Future Information Technology (FutureTech2017), held in Seoul, South Korea on May 22–24, 2017. These two conferences provided an opportunity for academic and industrial professionals to discuss recent advances in the area of multimedia and ubiquitous environments including models and systems, new directions, and novel applications associated with the utilization and acceptance of ubiquitous computing devices and systems. The resulting papers address the latest technological innovations in the fields of digital convergence, multimedia convergence, intelligent applications, embedded systems, mobile and wireless communications, bio-inspired computing, grid and cloud computing, semantic web, user experience, HCI, and security and trust computing. The book offers a valuable resource for a broad readership, including students, academic researchers, and...

  18. PREFACE 12th International Workshop on Slow Positron Beam Techniques

    Science.gov (United States)

    Buckman, Stephen; Sullivan, James; White, Ronald

    2011-01-01

    Preface These proceedings arose from the 12th International Workshop on Slow Positron Beam Techniques (SLOPOS12), which was held on Magnetic Island, North Queensland, Australia, between 1-6th August 2010. Meetings in the SLOPOS series are held (roughly) every three years and have now been held on (almost) all continents, indicating the truly international nature of the field. SLOPOS12 marked the second time that the Workshop had been held in the southern hemisphere, and the first time in Australia. SLOPOS12 attracted 122 delegates from 16 countries. Most encouraging was the attendance of 28 student delegates, and that about half of the overall delegates were early career researchers - a good sign for the future of our field. We also enjoyed the company of more than a dozen partners and families of delegates. In a slight departure from previous SLOPOS meetings, the International Advisory Committee approved a broader scope of scientific topics for inclusion in the program for the 2010 Workshop. This broader scope was intended to capture the applications of positrons in atomic, molecular and biomedical areas and was encapsulated in the byeline for SLOPOS-12: The 12th International Workshop on Slow Positron Beam Techniques for Solids, Surfaces, Atoms and Molecules. The scientific and social program for the meeting ran over 6 days with delegates gathering on Sunday August 1st and departing on August 6th. The scientific program included plenary, invited, contributed and student lectures, the latter being the subject of a student prize. In all there were 53 oral presentations during the week. There were also two poster sessions, with 63 posters exhibited, and a prize was awarded for the best poster by a student delegate. The standard of the student presentations, both oral and posters, was outstanding, so much so that the judging panel recommended an additional number of prizes be awarded. Topics that were the focus of invited presentations and contributed papers at

  19. CO2 emissions and economic development: China's 12th five-year plan

    International Nuclear Information System (INIS)

    Meng Ming; Niu Dongxiao; Shang Wei

    2012-01-01

    For the period of the 12th Five-Year Plan (2011–2015), the Chinese government has decided to reconsider and adjust its policies on economic development because of the pressures of CO 2 emissions and fossil energy consumption. The current paper adopts the logarithmic Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model to simulate the relationship between CO 2 emissions and other economic development factors in China. Three groups of outliers are found using samples from 1989 to 2008 and the Partial Least Square (PLS) regularity test method. The outlier analysis reveals three important areas for CO 2 reduction: (a) decreasing the share of coal to the total energy consumption and replacing it with non-fossil energies; (b) controlling vehicles used in the cities as well as (c) adjusting industrial structure. Furthermore, based on the social and economic realities of China, the current paper designs six feasible development scenarios for the period covered by the 12th Five-Year Plan and predicts the values of each factor in each scenario. The values can test the implementation of China's CO 2 control development concept. The experiences obtained by outlier analysis can be of significant reference value for realizing the predicted scenarios. - Highlights: ► Using STIRPAT to analyze China's CO 2 emissions and economic development factors. ► Using the PLS outlier test method, three groups of outliers are found. ► Outlier analysis reveals three important areas on reducing CO 2 emissions. ► We design six feasible scenarios for the period covered by the 12th Five-Year Plan. ► We predict the values of each factor in each scenario.

  20. Target post-evaluation of China's “12th Five-Year” oil and gas exploration and development planning and its “13th Five-Year” target prediction

    Directory of Open Access Journals (Sweden)

    Jiping Pan

    2016-03-01

    Full Text Available In the turn of 12th and 13th “Five-Year Plan” of China, the global oil and gas market changes greatly. In this regard, the target post-evaluation of the “12th Five-Year” oil and gas exploration and development planning was conducted, which is of significant importance to scientifically and reasonably making the specific “13th Five-Year” oil and gas exploration and development target planning. The post-evaluation results indicate that, in the period of “12th Five-Year Plan”, the oil and gas exploration and development targets of China were satisfactorily completed, but some deficiencies still existed. For example, the target of oil production (2 × 108 t was overfulfilled, while the target of oil reserves (65 × 108 t remained 6.4% outstanding. The target of gas reserves (3.5 × 1012 m3 was overfulfilled, while the target of gas production (1385 × 108 m3 remained 6.2% outstanding. Moreover, the targets of unconventional gases were not satisfactorily completed-shale gas being better than coalbed methane (CBM. Failures to fulfill some targets in “12th Five-Year Plan” were primarily attributed to the slowdown of oil and gas consumption growth, sharp drop of oil price, downgrading of resources, and changes of statistic basis under the new normal. The forecast results suggest that, in the period of “13th Five-Year Plan”, given USD50–70/bbl of world oil price, China's annual average incremental conventional oil and gas in place will be 10.0 × 108–12.0 × 108 t and 6000 × 108–8000 × 108 m3 respectively, annual average incremental shale gas and CBM in place will be 1000 × 108–2000 × 108 m3 and 500 × 108–1000 × 108 m3 respectively, and annual oil production will be about 2.0 × 108 t. By 2020, China's annual gas production will approach 1800 × 108–2000 × 108 m3 (shale gas: 200 × 108 m3, and CBM: 150 × 108 m3.

  1. Soldering Technology (6th) Proceedings of Annual Seminar, 17-18 February 1982.

    Science.gov (United States)

    1982-02-01

    aspect oF health and safety during this presentation. We are hoping that the work conducted by Van 2 Der Molen in the USA will clarify this issue. FLUX... Der Molen , PROC. OF 5th ANNUAL SEMINAR SOLDERING TECHNOLOGY, Naval Weapons Centre, China Lake, California, February 1981. 3. Burge, Perks, O’Brien...developed a new and innovative solution, which we believe to be a significant advance in the state of the art. In this new design (Fig.l) a FM DER

  2. Assessment of China's renewable energy contribution during the 12th Five Year Plan

    International Nuclear Information System (INIS)

    Hong, Lixuan; Zhou, Nan; Fridley, David; Raczkowski, Chris

    2013-01-01

    In recent years, China has been ambitious in investing and developing renewable energy technologies, aiming to enhance its energy security, mitigate its energy-related CO 2 emissions and develop renewable energy industry. The 12th Five Year Plan (2011–2015) has set clear targets on installed capacities of different renewable energy technologies. This study aimed to assess the possible contribution of 12th Five Year Plan for China's future energy system and identify factors that might influence its impacts. First, current status of renewable energy development in China has been reviewed. Then several energy scenarios have been developed in an hourly simulation using an energy system analysis tool EnergyPLAN. It was identified that existing grid bottleneck would greatly reduce the potential contribution of renewable installations in terms of share of renewable electricity generation, share of non-fossil fuels in primary energy and system CO 2 emissions. In contrast, improving technical performance of renewable energy technologies and sectoral energy efficiency plays an important role in increasing the share of renewables and promoting China’s energy system transition. Finally, some policy suggestions were drawn to facilitate a better implementation of the renewable energy plan. - Highlights: • China's renewable energy contribution during the 12th Five Year Plan was assessed. • Non-fossil fuel targets in primary energy for 2015 and 2020 could be easily achieved. • Grid bottlenecks severely decrease the share of RES-E in electricity generation through the 12th Five Year Period. • Improved technical performance of renewable technologies and sectoral energy efficiency are extremely important for achieving higher RES-E share. • Several policy suggestions were drawn

  3. TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families.

    Directory of Open Access Journals (Sweden)

    Yun Kyung Lee

    Full Text Available The development of Th17 cells is accompanied by the acquisition of responsiveness to both IL-12 and IL-23, cytokines with established roles in the development and/or function of Th1 and Th17 cells, respectively. IL-12 signaling promotes antigen-dependent Th1 differentiation but, in combination with IL-18, allows the antigen-independent perpetuation of Th1 responses. On the other hand, while IL-23 is dispensable for initial commitment to the Th17 lineage, it promotes the pathogenic function of the Th17 cells. In this study, we have examined the overlap between Th1 and Th17 cells in their responsiveness to common pro-inflammatory cytokines and how this affects the antigen-independent cytokine responses of Th17 cells. We found that in addition to the IL-1 receptor, developing Th17 cells also up-regulate the IL-18 receptor. Consequently, in the presence of IL-1β or IL-18, and in the absence of TCR activation, Th17 cells produce Th17 lineage cytokines in a STAT3-dependent manner when stimulated with IL-23, and IFN© via a STAT4-dependent mechanism when stimulated with IL-12. Thus, building on previous findings of antigen-induced plasticity of Th17 cells, our results indicate that this potential of Th17 cells extends to their cytokine-dependent antigen-independent responses. Collectively, our data suggest a model whereby signaling via either IL-1β or IL-18 allows for bystander responses of Th17 cells to pathogens or pathogen products that differentially activate innate cell production of IL-12 or IL-23.

  4. 11{sup th} and 12{sup th} draft laws amending the Atomic Energy Act; Die Gesetzentwuerfe zur elften und zwoelften Aenderung des Atomgesetzes

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Horst

    2010-11-15

    On September 28, 2010, the German Federal Government adopted the energy concept and, in addition, 2 draft amendments to the Atomic Energy Act to assist the coalition groups in the wording. The coalition groups tabled the 2 drafts in the Federal Parliament the same day. The subject of the 11{sup th} amending law is the extended plant life of nuclear power plants, that of the 12{sup th} amending law, the transposition into national law of the EURATOM Safety Directive of June 2009, the re-introduction of expropriation provisions about final storage, and the duty of operators to enhance the safety of existing nuclear power plants. The Federal Government's energy concept contains this statement about nuclear power: An extension for a limited period of time of the plant life of existing nuclear power plants makes a key contribution to ensuring, for an interim period of time, the three energy policy goals of climate protection, economy, and security of supply in Germany. It eases the way into the era of renewable energies, especially by its controlling effect on the price of electricity and by reducing greenhouse gas emissions related to power production.'' The amendment to the Atomic Energy Act, which does not require the consent of the Federal Council, extends the operating life of nuclear power plants by an average of 12 years. The EURATOM Safety Directive must be transposed into national law by July 22, 2011. The draft of a 12{sup th} amendment to the Atomic Energy Act submitted to this end, which also requires no consent of the Federal Council, bases its reasoning on the fact that most of the important requirements in the Directive had already been taken care of in Germany. Under the 12{sup th} amendment to the Atomic Energy Act, the expropriation regulations deemed to be necessary for repository storage, which had been introduced in the 1998 amendment to the Atomic Energy Act and abolished by the opt-out amendment of 2002, are to be reinstated. (orig.)

  5. Distributed Computing and Artificial Intelligence, 12th International Conference

    CERN Document Server

    Malluhi, Qutaibah; Gonzalez, Sara; Bocewicz, Grzegorz; Bucciarelli, Edgardo; Giulioni, Gianfranco; Iqba, Farkhund

    2015-01-01

    The 12th International Symposium on Distributed Computing and Artificial Intelligence 2015 (DCAI 2015) is a forum to present applications of innovative techniques for studying and solving complex problems. The exchange of ideas between scientists and technicians from both the academic and industrial sector is essential to facilitate the development of systems that can meet the ever-increasing demands of today’s society. The present edition brings together past experience, current work and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems. This symposium is organized by the Osaka Institute of Technology, Qatar University and the University of Salamanca.

  6. 12th Brazilian Meeting on Bayesian Statistics

    CERN Document Server

    Louzada, Francisco; Rifo, Laura; Stern, Julio; Lauretto, Marcelo

    2015-01-01

    Through refereed papers, this volume focuses on the foundations of the Bayesian paradigm; their comparison to objectivistic or frequentist Statistics counterparts; and the appropriate application of Bayesian foundations. This research in Bayesian Statistics is applicable to data analysis in biostatistics, clinical trials, law, engineering, and the social sciences. EBEB, the Brazilian Meeting on Bayesian Statistics, is held every two years by the ISBrA, the International Society for Bayesian Analysis, one of the most active chapters of the ISBA. The 12th meeting took place March 10-14, 2014 in Atibaia. Interest in foundations of inductive Statistics has grown recently in accordance with the increasing availability of Bayesian methodological alternatives. Scientists need to deal with the ever more difficult choice of the optimal method to apply to their problem. This volume shows how Bayes can be the answer. The examination and discussion on the foundations work towards the goal of proper application of Bayesia...

  7. 12th International Symposium on Experimental Robotics

    CERN Document Server

    Kumar, Vijay; Sukhatme, Gaurav

    2014-01-01

    The International Symposium on Experimental Robotics (ISER) is a series of bi-annual meetings which are organized in a rotating fashion around North America, Europe and Asia/Oceania. The goal of  ISER is to provide a forum for research in robotics that focuses on novelty of theoretical contributions validated by experimental results. The meetings are conceived to bring together, in a small group setting, researchers from around the world who are in the forefront of experimental robotics research. This unique reference presents the latest advances across the various fields of robotics, with ideas that are not only conceived conceptually but also explored experimentally. It collects robotics contributions on the current developments and new directions in the field of experimental robotics, which are based on the papers presented at the 12th ISER held on December 18-21, 2010 in New Delhi and Agra, India.This present twelfth edition of Experimental Robotics edited by Oussama Khatib, Vijay Kumar and Gaurav Sukha...

  8. 7th International Conference on Embedded and Multimedia Computing (EMC-12)

    CERN Document Server

    Jeong, Young-Sik; Park, Sang; Chen, Hsing-Chung; Embedded and Multimedia Computing Technology and Service

    2012-01-01

    The 7th International Conference on Embedded and Multimedia Computing (EMC-12), will be held in Gwangju, Korea on September 6 - 8, 2012. EMC-12 will be the most comprehensive conference focused on the various aspects of advances in Embedded and Multimedia (EM) Computing. EMC-12 will provide an opportunity for academic and industry professionals to discuss the latest issues and progress in the area of EM. In addition, the conference will publish high quality papers which are closely related to the various theories and practical applications in EM. Furthermore, we expect that the conference and its publications will be a trigger for further related research and technology improvements in this important subject. The EMC-12 is the next event, in a series of highly successful International Conference on Embedded and Multimedia Computing, previously held as EMC 2011 (China, Aug. 2011), EMC 2010 (Philippines, Aug. 2010), EM-Com 2009 (Korea, Dec. 2009), UMC-08 (Australia, Oct. 2008), ESO-08(China, Dec. 2008), UMS-08 ...

  9. Mental and somatic health complaints associated with school bullying between 10th and 12th grade students; results from cross sectional studies in Oslo, Norway

    OpenAIRE

    Lien, Lars; Green, Kristian; Welander-Vatn, Audun; Bjertness, Espen

    2009-01-01

    Background Bullying is a widespread and serious problem that might influence both mental and psychical well being as well as school performance and social life. The aim of this study was to describe the prevalence of bullying, mental health problems and psychical complaints among 10th and 12th grade students and to analyze the association between bullying, mental health problems and muscle and skeletal complaints. Metho...

  10. Mesures de procédure spéciales et respect des droits de l'homme
    Rapport général

    Directory of Open Access Journals (Sweden)

    John A.E. Vervaele

    2009-10-01

    Full Text Available Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le terrorisme et la criminalité organisée, et de voir si cela a conduit les pays à se départir de leur propres règles fondamentales, procédures, principes et standards des droits de l’homme applicables. Partant de la prémisse qu’un système intégré de droit pénal a trois dimensions – la protection des individus (la dimension de bouclier, la mise à disposition d’instruments d’application de la loi (la dimension d’épée et les contrôles et équilibres c’est-à-dire la séparation des pouvoirs (la dimension constitutionnelle – le rapport fournit un aperçu d’ensemble des transformations corrélées, surtout dans la procédure d’enquête préliminaire, qui les ont affectées toutes les trois dans trois vagues de « guerre » (contre la drogue, le crime organisé et le terrorisme. Dans beaucoup de pays, les garanties procédurales et les principes qui protègent contre la violation du droit à un procès équitable sont considérés comme un fardeau du point de vue de l’efficacité de l’application de la loi à la criminalité grave. Ces réformes se sont traduites par une claire extension de l’état répressif et un estompement des distinctions classiques, et ne favorisent pas la primauté du droit. La focalisation sur la sécurité publique et les investigations contraignantes préventives sapent le système de justice pénale. Avec l’usage croissant du système de justice criminelle comme instrument de régulation du présent et/ou de l’avenir plutôt que de sanction d’un comportement passé, et un procès pénal dans lequel l’enquête préliminaire ne concerne pas la recherche de la v

  11. Systemic Resistance to Powdery Mildew in Brassica napus (AACC) and Raphanus alboglabra (RRCC) by Trichoderma harzianum TH12.

    Science.gov (United States)

    Alkooranee, Jawadayn Talib; Yin, Yongtai; Aledan, Tamarah Raad; Jiang, Yingfen; Lu, Guangyuan; Wu, Jiangsheng; Li, Maoteng

    2015-01-01

    Trichoderma harzianum TH12 is a microbial pesticide for certain rapeseed diseases. The mechanism of systemic resistance induced by TH12 or its cell-free culture filtrate (CF) in Brassica napus (AACC) and Raphanus alboglabra (RRCC) to powdery mildew disease caused by ascomycete Erysiphe cruciferarum was investigated. In this study, we conducted the first large-scale global study on the cellular and molecular aspects of B. napus and R. alboglabra infected with E. cruciferarum. The histological study showed the resistance of R. alboglabra to powdery mildew disease. The growth of fungal colonies was not observed on R. alboglabra leaves at 1, 2, 4, 6, 8, and 10 days post-inoculation (dpi), whereas this was clearly observed on B. napus leaves after 6 dpi. In addition, the gene expression of six plant defense-related genes, namely, PR-1, PR-2 (a marker for SA signaling), PR-3, PDF 1.2 (a marker for JA/ET signaling), CHI620, and CHI570, for both genotypes were analyzed in the leaves of B. napus and R. alboglabra after treatment with TH12 or CF and compared with the non-treated ones. The qRT-PCR results showed that the PR-1 and PR-2 expression levels increased in E. cruciferarum-infected leaves, but decreased in the TH12-treated leaves compared with leaves treated with CF. The expression levels of PR-3 and PDF1.2 decreased in plants infected by E. cruciferarum. However, expression levels increased when the leaves were treated with TH12. For the first time, we disclosed the nature of gene expression in B. napus and R. alboglabra to explore the resistance pathways in the leaves of both genotypes infected and non-infected by powdery mildew and inoculated or non-inoculated with elicitor factors. Results suggested that R. alboglabra exhibited resistance to powdery mildew disease, and the application of T. harzianum and its CF are a useful tool to facilitate new protection methods for resist or susceptible plants.

  12. The description and symbolic value of the unicorn in French literature of the 12th and 13th centuries

    Directory of Open Access Journals (Sweden)

    Marija Panić

    2016-02-01

    Full Text Available The paper considers naturalist and symbolic traits attributed to the unicorn in French 12th and 13th century literature. The corpus encompasses the bestiaries comprised by Philippe de Thaon, Gervaise, Guillaume de Normandy, Pierre de Beauvais, Richard de Fournival and pseudo-Pierre de Beauveis, which belong to the tradition of the Physiologoi, as well as other encyclopedic and other works which contain the bookish zoological and geographic knowledge of the middle ages: Mappemonde by Pierre de Beauvais, The letter of presbyter John, and the Mappemonde by Gossouin de Metz. In this corpus where the description of the animals comes mainly from the same written sources (from antiquity and late antiquity and the Bible, we consider how this nonexistent animal is described and to what extent a symbolic interpretation is present.

  13. Ecclesiastical architecture in Álava and Treviño during the 12th and 13th centuries: promoters, builders and meanings in a transitional moment

    Directory of Open Access Journals (Sweden)

    Egoitz Alfaro Suescun

    2017-12-01

    Full Text Available This paper presents a reflection on church building in Álava and Treviño regions (north-central Spain during the 12th and 13th centuries. The study aims at tracking the transformations occurred in the promoters’ idiosyncrasy, the builders’ organizational model and both the function and meaning of these temples. More than a hundred cases have been analyzed to this end, so as to determine the variables involving their construction. Three main phases have been established according to changes documented in stonemasonry: period 1 (1100-1250, period 2 (1220-1250 and period 3 (1220-1300. The combined assessment of both the aforementioned variables and phases shows the existence of two major shifts in the ecclesiastical architecture of these centuries with regard to the previous period, constituting the 12th century itself kind of a transitional stage. These changes are seen in both the demand –economically, temporally and structurally more feasible buildings– and the supply – increasingly homogeneous temples–

  14. Target Allocation Methodology for China's Provinces: Energy Intensity in the 12th FIve-Year Plan

    Energy Technology Data Exchange (ETDEWEB)

    Ohshita, Stephanie; Price, Lynn

    2011-03-21

    Experience with China's 20% energy intensity improvement target during the 11th Five-Year Plan (FYP) (2006-2010) has shown the challenges of rapidly setting targets and implementing measures to meet them. For the 12th FYP (2011-2015), there is an urgent need for a more scientific methodology to allocate targets among the provinces and to track physical and economic indicators of energy and carbon saving progress. This report provides a sectoral methodology for allocating a national energy intensity target - expressed as percent change in energy per unit gross domestic product (GDP) - among China's provinces in the 12th FYP. Drawing on international experience - especially the European Union (EU) Triptych approach for allocating Kyoto carbon targets among EU member states - the methodology here makes important modifications to the EU approach to address an energy intensity rather than a CO{sub 2} emissions target, and for the wider variation in provincial energy and economic structure in China. The methodology combines top-down national target projections and bottom-up provincial and sectoral projections of energy and GDP to determine target allocation of energy intensity targets. Total primary energy consumption is separated into three end-use sectors - industrial, residential, and other energy. Sectoral indicators are used to differentiate the potential for energy saving among the provinces. This sectoral methodology is utilized to allocate provincial-level targets for a national target of 20% energy intensity improvement during the 12th FYP; the official target is determined by the National Development and Reform Commission. Energy and GDP projections used in the allocations were compared with other models, and several allocation scenarios were run to test sensitivity. The resulting allocations for the 12th FYP offer insight on past performance and offer somewhat different distributions of provincial targets compared to the 11th FYP. Recommendations for

  15. The 12th International Workshops on Opportunistic Protists (IWOP-12).

    Science.gov (United States)

    Weiss, Louis M; Cushion, Melanie T; Didier, Elizabeth; Xiao, Lihua; Marciano-Cabral, Francine; Sinai, Anthony P; Matos, Olga; Calderon, Enrique J; Kaneshiro, Edna S

    2013-01-01

    The 12th International Workshops on Opportunistic Protists (IWOP-12) was held in August 2012 in Tarrytown, New York. The objectives of the IWOP meetings are to: (1) serve as a forum for exchange of new information among active researchers concerning the basic biology, molecular genetics, immunology, biochemistry, pathogenesis, drug development, therapy, and epidemiology of these immunodeficiency-associated pathogenic eukaryotic microorganisms that are seen in patients with AIDS and (2) foster the entry of new and young investigators into these underserved research areas. The IWOP meeting focuses on opportunistic protists, e.g. the free-living amoebae, Pneumocystis, Cryptosporidium, Toxoplasma, the Microsporidia, and kinetoplastid flagellates. This conference represents the major conference that brings together research groups working on these opportunistic pathogens. Slow but steady progress is being achieved on understanding the biology of these pathogenic organisms, their involvement in disease causation in both immune-deficient and immune-competent hosts, and is providing critical insights into these emerging and reemerging pathogens. This IWOP meeting demonstrated the importance of newly developed genomic level information for many of these pathogens and how analysis of such large data sets is providing key insights into the basic biology of these organisms. A great concern is the loss of scientific expertise and diversity in the research community due to the ongoing decline in research funding. This loss of researchers is due to the small size of many of these research communities and a lack of appreciation by the larger scientific community concerning the state of art and challenges faced by researchers working on these organisms. © 2013 The Author(s) Journal of Eukaryotic Microbiology © 2013 International Society of Protistologists.

  16. “Crisis and Crisis Scenarios: Normativity, Possibilities and Dilemmas” (Lysebu Conference Centre in Oslo, Norway, April 9th12th, 2015

    Directory of Open Access Journals (Sweden)

    Øjvind Larsen

    2016-03-01

    Full Text Available This special issue of Nordicum-Mediterraneum contains select proceedings from the third meeting of the Nordic Summer University research circle called “Crisis and Crisis Scenarios: Normativity, Possibilities and Dilemmas”, held April 9th12th, 2015 at the Lysebu Conference Centre in Oslo, Norway. The circle’s research program runs from 2014 to 2016 and is aimed at examining the concept of crisis as it is used today in academia and public discussion. In this collection of papers from the symposium we present some of the different ways in which the topic of the study group was addressed.

  17. High-density fluid-perturbation theory based on an inverse 12th-power hard-sphere reference system

    International Nuclear Information System (INIS)

    Ross, M.

    1979-01-01

    A variational theory is developed that is accurate at normal liquid densities and densities up to 4 times that of the argon triple point. This theory uses the inverse 12th-power potential as a reference system. The properties of this reference system are expressed in terms of hard-sphere packing fractions by using a modified form of hard-space variational theory. As a result of this ''bootstrapping,'' a variational procedure may be followed that employs the inverse 12th-power system as a reference but uses the hard-sphere packing fraction as the scaling parameter with which to minimize the Helmholtz free energy

  18. Proceedings of 6th International Microbeam Workshop/12th L.H. Gray Workshop Microbeam Probes of Cellular Radiation Response

    International Nuclear Information System (INIS)

    Prise, Kevin M.

    2004-01-01

    The extended abstracts which are submitted here present a summary of the proceedings of the 6th International Workshop/12th LH Gray Workshop: Microbeam Probes of Cellular Radiation Response, held at St. Catherine's College, University of Oxford, UK on March, 29th-31st, 2003. In 1993 the 4th LH Gray Workshop entitled ''Microbeam Probes of Cellular Radiation Response'' was held at the Gray Cancer Institute in Northwood. This was organized by Prof BD Michael, Dr M. Folkard and Dr KM Prise and brought together 40 participants interested in developing and applying new microbeam technology to problems in radiation biology (1). The workshop was an undoubted success and has spawned a series of subsequent workshops every two years. In the past, these workshops have been highly successful in bringing together groups interested in developing and applying micro-irradiation techniques to the study of cell and tissue damage by ionizing radiations. Following the first microbeam workshop, there has been a rapid growth in the number of centres developing radiobiology microbeams, or planning to do so and there are currently 15-20 worldwide. Much of the recent research using microbeams has used them to study low-dose effects and ''non-targeted'' responses such bystander effects, genomic instability and adaptive responses. The goal of the 6th workshop was to build on our knowledge of the development of microbeam approaches and the application to radiation biology in the future with the meeting stretching over a 3 day period. Over 80 participants reviewed the current state of radiobiology microbeam research worldwide and reported on new technological developments both in the fields of physics and biology

  19. Determination of 232Th, 230Th and 228Th in liquid effluents from uranium mining

    International Nuclear Information System (INIS)

    Godoy, Jose Marcus de Oliveira

    1979-10-01

    A liquid scintillator αlpha spectrometer was built for the determination of Th- 228 , Th- 230 and Th- 232 in liquid effluents from Uranium mines and mills. The resolution of the αlpha spectrometer was found to be 200-300 KeV, when the scintillator was 8% T0P0, 0,77% scintimix-4 (91% PP0 and 9% Dimetil-P0P0P) and 10% of naphthalene in toluene. Aliquat-336 in xylene (30% v/v) was used to separate the thorium isotopes from other interfering radionuclides (U- 238 , U- 234 , Ra- 226 , Po- 210 ). Under the extraction experimental conditions, the detection limits were 1,2 pCi/1 for Th- 232 , 1,2 pCi/1 for Th- 230 and 0,9 pCi/1 for Th- 228 , for 1000 minutes of counting time. (author)

  20. Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide.

    Science.gov (United States)

    Annunziato, F; Cosmi, L; Manetti, R; Brugnolo, F; Parronchi, P; Maggi, E; Nagata, K; Romagnani, S

    2001-11-01

    The chemoattractant receptor homologous molecule expressed on T(H)2 cells (CRTH2) is a receptor for prostaglandin D(2), which among human T cells is selectively expressed by T(H)2 and type 2 cytotoxic effectors. Our purpose was to assess whether the cytokine production profile of T(H)2 effectors could be reversed by exploiting their selective expression of CRTH2. CRTH2(+) T cells were purified from the blood of allergic subjects, stimulated with the specific allergen in the absence or presence of IL-12, and assessed by flow cytometry at the single-cell level for their ability to produce IL-4 and/or IFN-gamma after antigen or polyclonal stimulation. Both IL-12 and the PS-DSP30 oligodeoxynucleotide enabled CRTH2(+) allergen-stimulated T(H)2 cells to produce IFN-gamma. This change in the profile of cytokine production by T(H)2 cells from allergic subjects was related to the upregulation of IL-12 receptor beta2 chain and was associated with the loss of CRTH2. These data demonstrate that the cytokine production pattern of fully differentiated T(H)2 effectors can be changed to a less polarized profile, thus providing the physiologic basis for new immunotherapeutic strategies in allergic disorders.

  1. The Shock and Vibration Digest, Volume 12, Number 9,

    Science.gov (United States)

    1980-09-01

    BLADES Nigeria, Intl. J. Earthquake Engr. Struc. Dynam., 8 (Also see No. 2033) (3), pp 219-236 JMay/3une 1980) 7 figs, 6 tables, 16 refs 80- 2048 Key...instability. 58 80-2059 VDI Bericht, No. 332, pp 241-261 (1979) 21 figs, Study on Bending Fatigue Strength of Helical Gears 9 refs (1st Report, Effect of...Westphal Space-Tronics, Inc., Life Cycle Problems and Environ- Universit~t Hanover, Hanover, Germany, VDI Z, 122 mental Technology, Proc. of the 26th

  2. The 12th International Symposium on Spermatology

    Science.gov (United States)

    Aitken, R John; Cummins, Jim M; Nixon, Brett

    2015-01-01

    The 12th International Symposium of Spermatology continued the excellent tradition of this meeting since its inception in 1969 when the first Symposium was held in Italy under the Chairmanship of Professor Baccio Baccetti. This unique Symposium is held every 4 years and serves as a beacon for sperm cell biologists from all over the world, regardless of which species, animal or plant, they are working on. This willingness to embrace the fundamental biology of this distinctive cell type without species limitations is one of the hallmarks of this Symposium. For sperm biologists – it is our Olympics. The meeting in Newcastle, NSW brought together around 300 biologists from more than 22 different countries covering North and South America, Africa, Europe, Asia and Australia. Given the considerable distances and high cost involved in travelling to the East Coast of NSW, this was an outstanding outcome. The Symposium featured a series of 31 plenary lectures culminating in the prestigious Thaddeus Mann Memorial Lecture, which was delivered with typical grace and brilliance by Professor Masaru Okabe. PMID:25994646

  3. Les charpentes à entrait retroussé moisé : exemples orléanais des XVe et XVIe siècles Braced collar-beam roofs: examples from 15th and 16th century Orleans

    Directory of Open Access Journals (Sweden)

    Clément Alix

    2010-03-01

    Full Text Available La ville d’Orléans possède un ensemble important et inédit de charpentes à pannes des XVe et XVIe s. présentant la particularité de posséder un entrait retroussé moisé. Attesté dès le premier quart du XVe siècle, ce procédé innovant, constitué de deux pièces jumelées venant enserrer les principaux éléments de la ferme, va largement se diffuser dans les édifices religieux mais surtout dans l’habitat domestique, de la maison polyvalente en pan-de-bois au riche hôtel particulier. Ce mode de construction, démontrant une parfaite maîtrise de la statique de la charpente dès sa conception en vue de renforcer la triangulation de la ferme, s’impose donc rapidement dans un contexte architectural local marqué par la rareté de l’emploi de structures à chevrons-formant-fermes. Ainsi, on le retrouve également dans les charpentes à enrayure (tourelle d’escalier, toiture en pavillon, abside. L’utilisation généralisée de la moise à Orléans, et de manière plus ponctuelle en val de Loire et dans certaines régions de France, amène aussi à s’interroger sur l’origine de ce procédé connu sous d’autres formes dans des charpentes dès les XIIe-XIIIe s.The town of Orleans possesses an important and unpublished collection of timber-framed roof structures of the 15th and 16th centuries, with a braced collar-beam. Known since the first quarter of the 15th century, this innovative process, involving two twinned pieces clasping the main elements of the frame, became widely spread in religious buildings but particularly in domestic housing, from the multipurpose timber-framed home to the elaborate town house. This method of construction, demonstrating a perfect mastery of the statics of a roof structure from its design with a view to reinforcing the triangulation of the truss, rapidly established itself in a local architectural context marked by the rare use of “chevrons-formant-fermes” (common rafters forming a

  4. The ONR-602 experiment and investigation of particle precipitation near the equator

    Science.gov (United States)

    Miah, M. A.

    1991-01-01

    The global precipitation of radiation belt particles at low altitude was investigated, using the ONR-602 experiment on board U.S. Air Force mission S81-1. A combination of a main telescope, beginning analysis at a few MeV/nucleon, and a monitor system, giving results below 1 MeV/nucleon, was designed for measuring particle phenomena characterized by almost any energy spectrum. The monitor provides an indication of the presence of the particles at low energy, while the main telescope gives detailed flux and composition data for the higher energy events. Results of the instrument performance analysis indicate that, at the equator, the monitor telescope has the peak efficiency for particles of about 90 deg pitch angles. The large opening angle of 75 deg makes it possible to detect omnidirectional flux of quasi-trapped particles. The high-energy cosmic-ray background count is found to be very insignificant. It is demonstrated that the particle counting rates for the low-energy threshold have been almost entirely due to protons.

  5. Idiopathic and normal lateral lumbar curves: muscle effects interpreted by 12th rib length asymmetry with pathomechanic implications for lumbar idiopathic scoliosis

    Directory of Open Access Journals (Sweden)

    Theodoros B. Grivas

    2016-10-01

    Full Text Available Abstract Background The historical view of scoliosis as a primary rotation deformity led to debate about the pathomechanic role of paravertebral muscles; particularly multifidus, thought by some to be scoliogenic, counteracting, uncertain, or unimportant. Here, we address lateral lumbar curves (LLC and suggest a pathomechanic role for quadrates lumborum, (QL in the light of a new finding, namely of 12th rib bilateral length asymmetry associated with idiopathic and small non-scoliosis LLC. Methods Group 1: The postero-anterior spinal radiographs of 14 children (girls 9, boys 5 aged 9–18, median age 13 years, with right lumbar idiopathic scoliosis (IS and right LLC less that 10°, were studied. The mean Cobb angle was 12° (range 5–22°. Group 2: In 28 children (girls 17, boys 11 with straight spines, postero-anterior spinal radiographs were evaluated similarly to the children with the LLC, aged 8–17, median age 13 years. The ratio of the right/left 12th rib lengths and it’s reliability was calculated. The difference of the ratio between the two groups was tested; and the correlation between the ratio and the Cobb angle estimated. Statistical analysis was done using the SPSS package. Results The ratio’s reliability study showed intra-observer +/−0,036 and the inter-observer error +/−0,042 respectively in terms of 95 % confidence limit of the error of measurements. The 12th rib was longer on the side of the curve convexity in 12 children with LLC and equal in two patients with lumbar scoliosis. The 12th rib ratios of the children with lumbar curve were statistically significantly greater than in those with straight spines. The correlation of the 12th rib ratio with Cobb angle was statistically significant. The 12th thoracic vertebrae show no axial rotation (or minimal in the LLC and no rotation in the straight spine group. Conclusions It is not possible, at present, to determine whether the 12th convex rib lengthening is

  6. 12th International Conference on Intelligent Autonomous Systems

    CERN Document Server

    Cho, Hyungsuck; Yoon, Kwang-Joon; Lee, Jangmyung

    2013-01-01

    Intelligent autonomous systems are emerged as a key enabler for the creation of a new paradigm of services to humankind, as seen by the recent advancement of autonomous cars licensed for driving in our streets, of unmanned aerial and underwater vehicles carrying out hazardous tasks on-site, and of space robots engaged in scientific as well as operational missions, to list only a few. This book aims at serving the researchers and practitioners in related fields with a timely dissemination of the recent progress on intelligent autonomous systems, based on a collection of papers presented at the 12th International Conference on Intelligent Autonomous Systems, held in Jeju, Korea, June 26-29, 2012. With the theme of “Intelligence and Autonomy for the Service to Humankind, the conference has covered such diverse areas as autonomous ground, aerial, and underwater vehicles, intelligent transportation systems, personal/domestic service robots, professional service robots for surgery/rehabilitation, rescue/security ...

  7. Deux théories de l'analyse psychique: Wundt et Brentano

    OpenAIRE

    Dewalque, Arnaud

    2014-01-01

    L’objectif de ce chapitre est de réévaluer succinctement les relations entre la phénoménologie et la psychologie expérimentale naissantes à partir des positions de Franz Brentano et de Wilhelm Wundt. Contrairement à une idée reçue, je suggère, d’une part, que les programmes analytiques de Brentano et de Wundt reposent tous deux sur un procédé expérimental consistant à faire varier les parties des phénomènes psychiques étudiés. Mais je suggère aussi, d’autre part, que les théories de l’analyse...

  8. 12th Workshop on Stochastic Models, Statistics and Their Applications

    CERN Document Server

    Rafajłowicz, Ewaryst; Szajowski, Krzysztof

    2015-01-01

    This volume presents the latest advances and trends in stochastic models and related statistical procedures. Selected peer-reviewed contributions focus on statistical inference, quality control, change-point analysis and detection, empirical processes, time series analysis, survival analysis and reliability, statistics for stochastic processes, big data in technology and the sciences, statistical genetics, experiment design, and stochastic models in engineering. Stochastic models and related statistical procedures play an important part in furthering our understanding of the challenging problems currently arising in areas of application such as the natural sciences, information technology, engineering, image analysis, genetics, energy and finance, to name but a few. This collection arises from the 12th Workshop on Stochastic Models, Statistics and Their Applications, Wroclaw, Poland.

  9. Development trends of remote sensing technology for uranium exploration in 12th Five Year

    International Nuclear Information System (INIS)

    Zhang Jielin

    2011-01-01

    This paper introduced the research status,application requirements, technique questions and development trends of remote sensing technology for uranium exploration in the 12th five year, and discussed the applicant prospects and potential of applied basic research innovation, thermal infrared hyperspectral and microwave remote sensing, 4D geological mapping and stereo exploration model in the uranium exploration. (authors)

  10. Report of the Two-Day National Seminar on New Directions in Higher Education, Organized by the Kerala State Higher Education Council on 12th and 13th July 2010

    Science.gov (United States)

    Praveen, C.

    2010-01-01

    This is a report of the Two-Day National Seminar on New Directions in Higher Education, organized by the Kerala State Higher Education Council on 12th and 13th July 2010. The objective of the seminar was to deliberate upon the reforms being undertaken by the Government of India in Higher Education. Reputed scholars from within and outside the…

  11. Concentration of thorium isotopes and the activity ratios of 230Th/232Th and 228Th/232Th in seawater in the Pacific Ocean

    International Nuclear Information System (INIS)

    Miyake, Yasuo; Sugimura, Yukio; Yasujima, Tadahide.

    1978-01-01

    The concentration of thorium isotopes and the activity ratios of 230 Th/ 232 Th and 228 Th/ 232 Th in 500 l sea water samples collected in the Pacific Ocean were determined. Thorium isotopes were analyzed by alpha-ray spectrometry after separating them from other elements with an anion exchange resin. The average content of thorium ( 232 Th) of 0.9 ng l -1 was obtained in the open Pacific water. The average contents of 230 Th and 228 Th were 2.1 x 10 -2 pgl -1 and 1.2 agl -1 respectively. It was found that the ratios of 230 Th/ 232 Th and 228 Th/ 232 Th ranged respectively from 1.0 to 29, and from 0.4 to as high as 128. (author)

  12. Magnetic properties of Fe-rich rare-earth intermetallic compounds with a ThMn12 structure

    International Nuclear Information System (INIS)

    Ohashi, K.; Tawara, Y.; Osugi, R.; Shimao, M.

    1988-01-01

    Sm(Fe/sub 1-//sub x/M/sub x/) 12 ternary compounds based on the tetragonal ThMn 12 structure where M is Ti, Si, V, Cr, and Mo were investigated. M atoms have a preference for site occupation. Ti atoms occupy the 8i or 8j site and Cr atoms occupy the 8i site. Curie temperatures on Sm(M,Fe) 12 compounds are around 590 K except for the SmMo 2 Fe 10 compound (T/sub c/ = 483 K). The SmTiFe 11 and SmSi 2 Fe 10 compounds have a high saturation magnetization and magnetic anisotropy

  13. DIMG92 : un simulateur de formation pour le procédé DIMERSOL Dimg92: a Training Simulator for the Dimersol Process

    OpenAIRE

    Nica A.; Capelle M.; Galtier F.

    2006-01-01

    DIMG92 est un simulateur de formation sur le procédé pétrochimique DIMERSOL (procédé IFP de dimérisation du propylène). En simulant le réacteur et ses équipements annexes, les opérateurs s'exercent à conduire l'unité et comprennent les effets des divers paramètres à prendre en compte. Le simulateur est composé de deux logiciels : - Un logiciel de modélisation, basé sur la représentation mathématique de connaissances physico-chimiques et physiques. Aucun empirisme n'est utilisé dans le modèle....

  14. Fasciola hepatica reinfection potentiates a mixed Th1/Th2/Th17/Treg response and correlates with the clinical phenotypes of anemia

    Science.gov (United States)

    Perez-Crespo, Ignacio; Chillón-Marinas, Carlos; Khoubbane, Messaoud; Quesada, Carla; Reguera-Gomez, Marta; Mas-Coma, Santiago; Fresno, Manuel; Gironès, Núria

    2017-01-01

    Background Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. Methodology/Principal findings The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats. In a cross-sectional study, the expression of the genes associated with Th1 (Ifng, Il12a, Il12b, Nos2), Th2 (Il4, Arg1), Treg (Foxp3, Il10, Tgfb, Ebi3), and Th17 (Il17) in the spleen and thymus was analyzed. After 20 weeks of primary infection, PI did not present significant changes in the expression of those genes when compared to non-infected rats (NI), but an increase of Il4, Arg1 and Ifng mRNA in the spleen was observed in R12, suggesting the existence of an active mixed Th1/Th2 systemic immune response in reinfection. Foxp3, Il10, Tgfb and Ebi3 levels increased in the spleen in R12 when compared to NI and PI, indicating that the Treg gene expression levels are potentiated in chronic phase reinfection. Il17 gene expression levels in R12 in the spleen increased when compared to NI, PI and R8. Gene expression levels of Il10 in the thymus increased when compared to NI and PI in R12. Ifng expression levels in the thymus increased in all reinfected rats, but not in PI. The clinical phenotype was determined by the fluke burden, the rat body weight and the hemogram. Multivariate mathematical models were built to describe the Th1/Th2/Th17/Treg expression levels and the clinical phenotype. In reinfection, two phenotypic patterns were detected: i) one which includes only increased splenic Ifng

  15. Increased Th1, Th17 and pro-fibrotic responses in hepatitis C-infected patients are down-regulated after 12 weeks of treatment with pegylated interferon plus ribavirin.

    Science.gov (United States)

    Jimenez-Sousa, Maria Angeles; Almansa, Raquel; de la Fuente, Concha; Caro-Paton, Agustín; Ruiz, Lourdes; Sanchez-Antolín, Gloria; Gonzalez, Jose Manuel; Aller, Rocio; Alcaide, Noelia; Largo, Pilar; Resino, Salvador; de Lejarazu, Raul Ortiz; Bermejo-Martin, Jesus F

    2010-06-01

    Hepatitis C virus causes significant morbidity and mortality worldwide. The infection induces up-regulation of cytokine and chemokines commonly linked to the development of cellular and pro-inflammatory antiviral responses. The current standard in hepatitis C treatment consists of combination regimens of pegylated interferon-alpha plus ribavirin. The impact of combined treatment in the host immune response is still poorly understood. In the present study, we profiled 27 cytokines, chemokines and growth factors involved in the innate and adaptive responses to the virus in the serum of 27 hepatitis C virus-infected patients, before and after 12 weeks of combined treatment, and compared them to 10 healthy controls. Hepatitis C virus infection induced not only the secretion of chemokines and cytokines participating in Th1 responses (MIP-1 alpha, IP-10, TNF-alpha, IL-12p70, IL-2), but also cytokines involved in the development of Th17 responses (IL-6, IL-8, IL-9 and IL-17) and two pro-fibrotic factors (FGF-b, VEGF). The most important increases included MIP-1 alpha (4.7-fold increase compared to the control group), TNF-alpha (3.0-fold), FGF-b (3.4-fold), VEGF (3.5-fold), IP-10 (3.6-fold), IL-17 (107.0-fold), IL-9 (7.5-fold), IL-12p70 (7.0-fold), IL-2 (5.6-fold) and IL-7 (5.6-fold). Combined treatment with pegylated interferon-alpha plus ribavirin down-modulated the secretion of key Th1 and Th17 pro-inflammatory mediators, and pro-fibrotic growth factors as early as 12 weeks after treatment initiation. MIP-1 alpha, FGF-b, IL-17 decreased in a more dramatic manner in the group of responder patients than in the group of non-responders (fold-change in cEVR; fold-change in NcEVR): MIP-1 alpha (4.72;1.71), FGF-b (4.54;1.21), IL-17 (107.1;1.8). Correlation studies demonstrated that the decreases in the levels of these mediators were significantly associated with each other, pointing to a coordinated effect of the treatment on their secretion (r coefficient; p value): [ FGF

  16. Regard d’ensemble sur la codification de la procédure civile

    OpenAIRE

    Carbonnier, Jean

    2014-01-01

    M. le Premier Président, merci. Merci M. le Procureur Général, c’est pour moi un très grand honneur. En m’appelant à cette place, vous saviez que la matière que j’avais longuement enseignée à l’université et qui inévitablement, en retour, m’avait imprégné et déformé, la sociologie juridique, me fixait d’emblée à une distance respectable et respectueuse de ce qui devait être le sujet de cette réunion de l’après-midi – savoir, dans une vue d’ensemble, la codification de la procédure civile – ; ...

  17. Contrôle et éléments de maîtrise de la contamination par la levure brettanomyces au cours du procédé de vinification en rouge

    OpenAIRE

    Barbin, Pascal

    2006-01-01

    Les levures du genre Dekkera/Brettanomyces sont reconnues comme les agents de contamination des vins rouges responsables des défauts phénolés et animaux. Une procédure complète de dépistage et d'isolement a été développée en associant plusieurs critères discriminants. Elle a permis de confirmer la présence du contaminant tout au long du procédé, de la matière première (raisins sur pieds), au produit fini (vin en bouteilles). Des études de terrain, en amont du procédé de vinification ont mis e...

  18. TNF-α inhibitors reduce the pathological Th1 -Th17 /Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients.

    Science.gov (United States)

    Campanati, Anna; Orciani, Monia; Lazzarini, Raffaella; Ganzetti, Giulia; Consales, Veronica; Sorgentoni, Giulia; Di Primio, Roberto; Offidani, Annamaria

    2017-04-01

    Psoriasis is a disease characterized by an imbalance between Th 1 and Th 17 and Th 2 inflammatory axes, in which cutaneous mesenchymal stem cells (MSCs) are early involved, as they show a greater relative expression of several genes encoding for Th 1 and Th 17 cytokines. Therapeutic implications of TNF-α inhibitors on differentiated skin cells have been largely described in psoriasis; however, their effects on MSCs derived from patients with psoriasis have been only partially described. The aim of this work was to evaluate the effect of TNF-α inhibitors on cytokine milieu expressed by MSCs isolated from the skin of patients with psoriasis. Resident MSCs from skin of patients with psoriasis and healthy subjects have been isolated, characterized and profiled by PCR and ELISA for the expression of 22 cytokines involved in Th 1 , Th 2 and Th 17 pathways, both before and after 12 weeks therapy with TNF-α inhibitors. The administration of TNF-α inhibitors for 12-weeks acts on MSCs as follows: it reduces the expression of several Th 1 -Th 17 cytokines whose levels are elevated at baseline (IL-6, IL-8, IL-12, IL-23A, IFN-γ, TNF-α, CCL2, CCL20, CXCL2, CXCL5, IL-17A, IL-17C, IL-17F, IL-21, G-CSF). Similarly, it enhances the expression of several Th 2 cytokines which are underexpressed at baseline (IL-2, IL-4, IL-5), reducing the expression of those overexpressed at baseline (TGF-β and IL-13). TNF-α inhibitors could contribute to reduce the pathological imbalance between the Th 1 -Th 17 vs Th 2 axis in MSCs of patients with psoriasis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Runtime extension and nuclear safety. On the legal and technological context of the 11th and 12th amendment of the Atomic Energy Act; Laufzeitverlaengerung und nukleare Sicherheit. Zum rechtlichen und technischen Zusammenhang von 11. und 12. AtG Novelle

    Energy Technology Data Exchange (ETDEWEB)

    Renneberg, Wolfgang [Renneberg Consult UG, Alfter (Germany)

    2011-04-15

    The 11th and 12 Amendment of the Atomic Energy Act with which on the one hand the runtime is extended and on the other hand the safety requirements have been renormalized, formally are independent legislative projects. Concerning to the contents, the 12th Amendment appears as an essential element for securing the extension of operation periods. At the same time it constitutes censorship in the safety assessment of nuclear power plants which is equivalent to a modification in the existing security philosophy. The relationships allowing this interpretation go beyond purely legal issues. Therefore the contribution under consideration reports on the legal, safety related and safety political genesis of the actual legal situation following the contributions of Rossnagel/Hentschel and Ziehm.

  20. 75 FR 10483 - Filing Dates for the Pennsylvania Special Election in the 12th Congressional District

    Science.gov (United States)

    2010-03-08

    ... in the 12th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Pennsylvania has scheduled a Special General Election on May 18... John P. Murtha. Committees required to file reports in connection with the Special General Election on...

  1. 12th International Conference on Nucleus-Nucleus Collisions

    CERN Document Server

    2015-01-01

    The NN2015 abstract submission page is now open. Please follow the NN2015 link "Submit a New Abstract" to submit a contribution. The contributing author who submits an abstract is considered to be the presenter if the abstract is selected. If the abstract has multiple co-authors, please list them, following the instructions on the web page. Contributors should submit their abstracts by Feb. 28th, 2015. The text, prepared according to the templates available on the web page, can be inserted in the apposite window. Alternatively, the corresponding file can be attached. All abstracts of contributed talks and posters will be reviewed by the Program Committee. Contributors will be informed whether their contributions have been selected for oral presentations in parallel sessions or accepted as posters after March 28th, 2015. All invited speakers are requested to provide their abstracts by March 28th, 2015.

  2. 78 FR 24069 - Safety Zone; 12th Annual Saltwater Classic; Port Canaveral Harbor; Port Canaveral, FL

    Science.gov (United States)

    2013-04-24

    ... under Executive Order 13045, Protection of Children from Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health...-AA00 Safety Zone; 12th Annual Saltwater Classic; Port Canaveral Harbor; Port Canaveral, FL AGENCY...

  3. 12th Czechoslovak seminar on plasma physics and technology

    International Nuclear Information System (INIS)

    1983-03-01

    The 12th Czechoslovak seminar on plasma physics and technology was oriented mainly to the problems of high-temperature plasmas and controlled thermonuclear fusion. The proceedings contain 27 invited papers and communications presented in three sections: 1) Inertial controlled fusion, 2) Tokamaks, 3) Theory and miscellaneous topics. The first group of papers deals with various problems of electron-beam, ion-beam, and laser fusion, including physical processes in fusion targets. The tokamak section discusses the latest experimental results achieved in the Russian tokamaks FT-2, Tuman 2-a, T-7 and T-10, in the Czechoslovak tokamak TM-1-MH, and in the Hungarian tokamak MT-1. A detailed survey is presented of work on neutral atom injectors in Novosibirsk. In the third section several papers on theoretical studies of nonlinear and turbulent processes in a hot plasma are presented together with a simulation study of a hybrid tokamak reactor. Several contributions on special diagnostic methods are presented. (J.U.)

  4. 12th International Conference on Multiple Criteria Decision Making

    CERN Document Server

    Gal, Tomas

    1997-01-01

    The organizers of the 12th International Conference on Multiple Cri­ teria Decision Making (MCDM) held June 19-23, 1995 in Hagen received the second time the opportunity to prepare an international conference on MCDM in Germany; the first opportunity has been the 3rd International Conference on MCDM in Konigswinter, 1979. Quite a time ellapsed since then and therefore it might be interesting to compare some indicators of the development of the International Society on MCDM, which has been founded in Konigswinter. Stanley Zionts has been elected first president and all 44 participants of that Conference became founding members. Today our Society has over 1200 members and its own Journal (MCDM World Scan). In Hagen, 1996, we had 152 participants from 34 countries. It is interesting to mention that also other Groups established their organi­ zation, like the European Working Group on Multiple Criteria Decision Aid, the German Working Group on Decision Theory and Applications, the Multi­ Objective Programming ...

  5. CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation.

    Science.gov (United States)

    Wang, Jiaoli; Zhu, Weiguo; Chen, Yinghu; Lin, Zhendong; Ma, Shenglin

    2016-11-01

    Predominant T helper (Th)2 and impaired Th1 cell polarization has a crucial role in the development of asthma. Cluster of differentiation (CD)38 is associated with the increased release of interleukin (IL)‑12 from dendritic cells (DCs) and DC‑induced Th1 cell polarization. However, whether CD38 expression affects DC function in asthma development remains unknown. In the current study, adenoviruses were constructed containing the murine CD38 gene. Overexpression of CD38 protein level in DCs induced from bone‑marrow derived DCs (BMDCs) by recombinant mouse granulocyte macrophage colony‑stimulating factor and IL‑4 was achieved through 24 h adenovirus infection. The results demonstrated that BMDCs with CD38 overexpression exhibited no phenotypic change; however, following stimulation with lipopolysaccharide (LPS), maturation and IL‑12 secretion were increased. In addition, CD38‑overexpressing BMDCs stimulated with LPS exhibited more effective Th1 cell differentiation. Mice that were administered CD38‑overexpressing BMDCs exhibited milder symptoms of asthma. Furthermore, decreased IL‑4, IL‑5 and IL‑13 levels were detected in bronchoalveolar lavage fluid (BALF), reduced immunoglobulin E levels were measured in the sera, and increased interferon‑γ was detected in BALF from the recipients of CD38‑overexpressing BMDCs. Increased phosphorylated‑p38 expression was also detected in LPS-stimulated CD38-overexpressing BMDCs, whereas pretreatment with a p38‑specific inhibitor was able to abolish the effects of LPS stimulation and CD38 overexpression on IL‑12 release and Th1 cell differentiation in BMDCs. These results suggested that CD38 may be involved in the DC function of alleviating asthma via restoration of the Th1/Th2 balance, thus providing a novel strategy for asthma therapy.

  6. Le thème de l’amour dans la tragédie cornélienne

    Directory of Open Access Journals (Sweden)

    Vasile Rădulescu

    2008-06-01

    Full Text Available Corneille s’est proposé, de manière programmatique, de traiter des sujets « sérieux », conformes à la « dignité » de la tragédie, combiné toujours avec le thème de l’amour, théoriquement considéré comme un agrément, destiné à attirer et à séduire le public. En pratique, les proportions sont égales, le thème de l’amour est traité aussi sérieusement que les thèmes « sérieux ». De plus, il est traité avec une grande virtuosité poétique, les manifestations lyriques sont bien contenues et renfermées dans des vers d’une beauté sans pareille. Pour cela, un arsénal de figures, de stratégies argumentatives et de procédés rhétoriques est mis à contribution. Le personnage cornélien débat, raisonne, mais il n’oublie jamais de faire surgir avec raffinement les élans de son cœur.

  7. Procédé et dispositif de lombrifiltration pour l'assainissement des eaux usées

    OpenAIRE

    DUCLOS, Lucie; FILLIT, Fabien; SOTO, Patricio; BRUNEAU, Denis

    2013-01-01

    L'objet de l'invention est un dispositif de lombrifiltration pour l'assainissement des eaux usées, dans une habitation individuelle comprenant un lombrifiltre (18) ainsi que des moyens (16) de prétraitement par réduction des dimensions des particules solides des effluents eaux usées, des moyens (20) de post-traitement et une sortie (22) des eaux claires. L'invention couvre également le procédé associé.

  8. 12th International Workshop on Low Temperature Electronics

    International Nuclear Information System (INIS)

    2017-01-01

    The present volume of the Journal of Physics: Conference Series represents contributions from participants of the 12th International Workshop on Low Temperature Electronics held in Tempe, Arizona, USA from September 18-21, 2016. The conference was organized by the School of Earth and Space Exploration at Arizona State University.The International Workshop on Low Temperature Electronics (WOLTE) is a biennial conference devoted to the presentation and exchange of the most recent advances in the field of low temperature electronics and its applications. This international forum is open to everyone in the field.The technical program included oral presentations and posters on fundamental properties of cryogenic materials, cryogenic transistors, quantum devices and systems, astronomy and physics instrumentation, and fabrication of cryogenic devices. More than 50 scientists and engineers from various academic, government, and industrial institutions in Europe, Asia, and the Americas attended the conference.We would like to thank all speakers for their presentations and all attendees for their participation. We would also like to express our sincerest gratitude to our sponsors: Lake Shore Cryotronics, ASU NewSpace, ASU School of Earth and Space Exploration, and IRA A. Fulton Schools of Engineering for making this conference possible. (paper)

  9. Modulation of chicken macrophage effector function by Th1/Th2 cytokines

    Science.gov (United States)

    Regulation of macrophage activity by TH1/2 cytokines is important to maintain the balance of immunity to provide adequate protective immunity while avoiding excessive inflammation. IFN-gamma and IL-4 are the hallmark TH1 and TH2 cytokines, respectively. In avian species, information concerning reg...

  10. Executive summary of the 12th HHT international scientific conference.

    Science.gov (United States)

    Andrejecsk, Jillian W; Hosman, Anna E; Botella, Luisa M; Shovlin, Claire L; Arthur, Helen M; Dupuis-Girod, Sophie; Buscarini, Elisabetta; Hughes, Christopher C W; Lebrin, Franck; Mummery, Christine L; Post, Marco C; Mager, Johannes J

    2018-02-01

    Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8-11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. In total 174 abstracts were accepted of which 58 were selected for oral presentations. This article covers the basic science and clinical talks, and discussions from three theme-based workshops. We focus on significant emergent themes and unanswered questions. Understanding these topics and answering these questions will help to define the future of HHT research and therapeutics, and ultimately bring us closer to a cure.

  11. Thinking Skills in the 12th Grade English Course book in Timor Leste

    Directory of Open Access Journals (Sweden)

    Joaninho Xavier Hei

    2017-07-01

    Full Text Available This study aims to analyze the English course book of (Manual do Aluno INGLÊS 12.o ano de escolaridade/Students’ English Manual for 12th Year Schooling in Timor Leste. The activities in the reading and listening sections of the course book were performed to determine whether they emphasized on lower or higher levels of cognitive process. The study attempted to answer the following question: Do the cognitive levels of the activities that relate to the focus on reading and listening in the 12th grade English course book sufficiently represent all the six levels of the New Bloom Taxonomy of thinking skills? The objective of this analysis was to discover the reading and listening activities that can sufficiently promote the levels of cognitive process. The activities determined as the criteria for analysis were: Wh-questions, true/false question, yes/no question, multiple choice question, complete the sentence phrase, a chart, matching questions, statement question, and a key word request question. The activities of the questions were gathered, listed with the total numbers of 161 questions and analyzed according to the six levels of New Bloom’s Taxonomy. The results showed that 98 activities emphasized mostly on lower levels cognitive order while only 63 activities emphasized the higher levels of thinking skills. So, the course book mentioned above targeted as a resource for students to learn the language, not as a resource for students to develop thinking skills because it fails to equip learners with the activities requiring higher levels of thinking order. By implication, for the teacher/syllabus designer can be aware to modify their own learning material by integrating more higher-order questions to achieve higher levels of thinking skills. Keywords: Course book Activities Analysis, and New Bloom’s Taxonomy

  12. A Content Analysis of Kindergarten-12th Grade School-Based Nutrition Interventions: Taking Advantage of Past Learning

    Science.gov (United States)

    Roseman, Mary G.; Riddell, Martha C.; Haynes, Jessica N.

    2011-01-01

    Objective: To review the literature, identifying proposed recommendations for school-based nutrition interventions, and evaluate kindergarten through 12th grade school-based nutrition interventions conducted from 2000-2008. Design: Proposed recommendations from school-based intervention reviews were developed and used in conducting a content…

  13. Diagnòstics d'infermeria vinculats al procés migratori: visió dels inmigrants

    OpenAIRE

    Rifà i Ros, Maria Rosa

    2012-01-01

    L’objectiu general d’aquesta investigació pretén identificar els diagnòstics d’infermeria NANDA predominants en la població immigrant, vinculats al procés migratori i està emmarcada en el Model de Competència Cultural de Purnell i en el model Outcome Present State Test (OPT) de raonament clínic de Pesut i Herman. Tenint en compte els objectius d’aquesta recerca, aquesta s’aborda des del paradigma qualitatiu i seguint les propostes de la investigació fenomenològica que busca descobrir els s...

  14. The Liber mahameleth a 12th-century mathematical treatise

    CERN Document Server

    Sesiano, Jacques

    2014-01-01

    The Liber mahameleth is a work in Latin written in the mid-12th century based (mainly) on Arabic sources from Islamic Spain. It is now our principal source on mathematics in Islamic Spain at that time; There are few extant Arabic texts and no one is as complete as the LM. It is also the second largest mathematical work from the Latin Middle Ages (the other is by Fibonacci, some 50 years later). Since the three main manuscripts preserving it are incomplete and there are many scribal errors, a reliable Latin text has been established, which reports (in notes) the various readings of the manuscripts and the errors in them. This is how a so-called critical edition is made. This edition of the Latin text is preceded by General Introduction, describing the various manuscripts, the content of the work and what we know about its author. Part Two of the volume is a translation of the text and ends with a glossary of Latin terms. The glossary will be of great importance for the knowledge of Latin scientific terms from ...

  15. Le Procès de Tôkyô, l’empereur et la question du Yasukuni The Tokyo trial, the emperor and the Yasukuni shrine

    Directory of Open Access Journals (Sweden)

    Tetsuya Takahashi

    2010-07-01

    Full Text Available Au Japon, toute une partie de la classe politique conservatrice persiste à refuser les conclusions du procès de Tôkyô, considérant celui-ci comme une justice « orchestrée par les vainqueurs ». Ce faisant, les partisans de cette thèse se trouvent dans une contradiction puisque l’empereur Hirohito lui-même, qui avait exprimé sa gratitude auprès des forces d’occupation américaines pour l’avoir épargné, en avait de facto admis les conclusions. Ce paradoxe pour le camp conservateur est aggravé par le fait que l’empereur a cessé de se rendre au sanctuaire Yasukuni à partir du moment où les mânes de quatorze haut responsables condamnés comme criminels de guerre lors du procès de Tôkyô y furent transférés sans son accord. Ces contradictions internes à la droite irrédentiste japonaise invite ainsi à envisager le procès de Tôkyô sous un autre jour. Loin d’être une simple « justice de vainqueur », la stratégie américaine fut éminemment bénéfique pour la droite conservatrice : Hirohito n’étant pas traduit en justice, il devenait possible de lui conférer une fonction symbolique par l’article I de la nouvelle Constitution de 1946, ce qui permit à la droite conservatrice de sauver le système impérial et d’assurer une continuité entre l’avant et l’après-guerre.In Japan, a part of the conservative political class continues to deny the conclusions of the Tokyo trial, as a justice “of the victors”. But the proponents of this theory face a contradiction since the Emperor Hirohito himself expressed his gratitude to the American occupation authority (SCAP for not condemning him. Hirohito therefore admitted the conclusions of the trial. The paradox goes even further as the conservative leaders publicize their visit to Yasukuni shrine although the Emperor himself ceased to visit the shrine after top leaders convicted as war criminals at the Tokyo Trial were transferred to the shrine without his

  16. Déconstruction-reconstruction identitaire et poétique de l’altérité dans Le procès-verbal de J-M G. Le Clézio

    Directory of Open Access Journals (Sweden)

    Abdoulaye Diouf

    2016-12-01

    Full Text Available En partant du double mouvement rhizomatique de la « déterritorialisation » et de la « reterritorialisation », cet article se propose d’étudier la conception dynamique de l’identité dans Le procès-verbal de Jean-Marie Gustave Le Clézio (1963. Pour cela, il explore, d’une part, le processus graduel de déconstruction identitaire du héros du roman (marginalité, nudité, métamorphose par le biais de la médiation altéritaire – dans le sens d’un rapport au monde et à l’Autre – à partir de laquelle se reconstruit une nouvelle identité transcendante loin de tout essentialisme. D’autre part, il analyse les différentes stratégies de mise en altérité qui montrent au passage, avec sa théorie de l’« extase matérialiste » et le principe de l’identification qui la sous-tend, que l’être ne s’arrête pas à l’humain chez Le Clézio. Starting from the dual rhizome-like movement of the “deterritorialization” and “reterritorialization”, this article proposes to study the dynamic concept of identity in Le procès-verbal by Jean-Marie Gustave Le Clézio (1963. For this, it explores, firstly, the gradual process of identity deconstruction of the novel’s hero (marginality, nudity, metamorphosis through the othering mediation - in the sense of a relationship to the world and the Other - from which is rebuilt a new transcendent identity away from all essentialism. Furthermore, it analyzes the different otherness implementation strategies that show the way, with his theory of “materialistic ecstasy” and the principle of identification which underlies it, according to which being goes beyond humans for Le Clézio.

  17. IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals

    Science.gov (United States)

    Villegas-Mendez, Ana; de Souza, J. Brian; Lavelle, Seen-Wai; Gwyer Findlay, Emily; Shaw, Tovah N.; van Rooijen, Nico; Saris, Christiaan J.; Hunter, Christopher A.; Riley, Eleanor M.; Couper, Kevin N.

    2013-01-01

    The IL-27R, WSX-1, is required to limit IFN-γ production by effector CD4+ T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in vivo during infection has not been investigated in detail. In this study we demonstrate that WSX-1 signalling suppresses the development of pathogenic, terminally differentiated (KLRG-1+) Th1 cells during malaria infection and establishes a restrictive threshold to constrain the emergent Th1 response. Importantly, we show that WSX-1 regulates cell-intrinsic responsiveness to IL-12 and IL-2, but the fate of the effector CD4+ T cell pool during malaria infection is controlled primarily through IL-12 dependent signals. Finally, we show that WSX-1 regulates Th1 cell terminal differentiation during malaria infection through IL-10 and Foxp3 independent mechanisms; the kinetics and magnitude of the Th1 response, and the degree of Th1 cell terminal differentiation, were comparable in WT, IL-10R1−/− and IL-10−/− mice and the numbers and phenotype of Foxp3+ cells were largely unaltered in WSX-1−/− mice during infection. As expected, depletion of Foxp3+ cells did not enhance Th1 cell polarisation or terminal differentiation during malaria infection. Our results significantly expand our understanding of how IL-27 regulates Th1 responses in vivo during inflammatory conditions and establishes WSX-1 as a critical and non-redundant regulator of the emergent Th1 effector response during malaria infection. PMID:23593003

  18. Detecting the Hormonal Pathways in Oilseed Rape behind Induced Systemic Resistance by Trichoderma harzianum TH12 to Sclerotinia sclerotiorum.

    Science.gov (United States)

    Alkooranee, Jawadayn Talib; Aledan, Tamarah Raad; Ali, Ali Kadhim; Lu, Guangyuan; Zhang, Xuekun; Wu, Jiangsheng; Fu, Chunhua; Li, Maoteng

    2017-01-01

    Plants have the ability to resist pathogen attack after infection or treatment with biotic and abiotic elicitors. In oilseed rape plant Brassica napus AACC and in the artificially synthesized Raphanus alboglabra RRCC, the root-colonizing Trichoderma harzianum TH12 fungus triggers induced systemic resistance (ISR), and its culture filtrate (CF) triggers a systemic acquired resistance (SAR) response against infection by the Sclerotinia sclerotiorum. Salicylic acid (SA) and jasmonic acid/ethylene (JA/ET) are plant hormone signals that play important roles in the regulation of ISR and SAR. In this study, at six different time points (1, 2, 4, 6, 8 and 10 days post-infection [dpi]), six resistance genes were used as markers of signaling pathways: JA/ET signaling used AOC3, PDF1.2 and ERF2 genes, while PR-1, TGA5 and TGA6 genes were used as markers of SA signaling. The results of quantitative real-time polymerase chain reaction (qRT-PCR) showed that AOC3, PDF1.2 and ERF2 expression levels in infected leaves of AACC and RRCC increase at 1 and 2 dpi with S. sclerotiorum or inoculation with TH12. PR-1, TGA5 and TGA6 expression levels increased at 8 and 10 dpi in infected leaves. PR-1, TGA5 and TGA6 expression levels increased early in plants treated with CF in both of the healthy genotypes. Furthermore, induction of SA- and JA/ET-dependent defense decreased disease symptoms in infected leaves at different times. The results suggest that the RRCC genotype exhibits resistance to disease and that the ability of TH12 and its CF to induce systemic resistance in susceptible and resistant oilseed rape genotypes exists. In addition, the results indicate for the first time that in RRCC the SA signaling pathway is involved in resistance to necrotrophic pathogens.

  19. Measuring and Modeling Behavioral Decision Dynamics in Collective Evacuation

    Science.gov (United States)

    2014-02-10

    1303.4629. 15. Leskovec J, Backstrom L, Kleinberg J (2009) Meme -tracking and the dynamics of the news cycle. Proc 15th ACM SIGKDD : 497505. 16. Leskovec J...2011) Memes online: Extracted, subtracted, injected, and recollected. Proc 5th Int AAAI Conf on Weblogs and Social Media : 353–360. 21. Watts DJ (2002) A

  20. In the Footsteps of Roger Revelle: a Partnership between SIO, ONR and Middle School Science Students

    Science.gov (United States)

    Brice, D.; Appelgate, T. B.; Foley, S.; Knox, R. A.; Mauricio, P.

    2010-12-01

    Now in its seventh year, “In the Footsteps of Roger Revelle” (IFRR) is a middle school science education program that draws student interest, scientific content and coherence with National Science Standards from real-time research at sea in fields of physical science. As a successful collaboration involving Scripps Institution of Oceanography (SIO), National Science Foundation (NSF),Office of Naval Research (ONR), and San Marcos Middle School (SMMS), IFRR brings physical oceanography and related sciences to students at the San Marcos Middle School in real-time from research vessels at sea using SIO's HiSeasNet satellite communication system. With a generous grant from ONR, students are able to tour the SIO ships and spend a day at sea doing real oceanographic data collection and labs. Through real-time and near-realtime broadcasts and webcasts, students are able to share data with scientists and gain an appreciation for the value of biogeochemical research in the field as it relates to their classroom studies. The primary impact on these students is an appreciation of ocean science as it relates to their lives. Interaction with scientists and researchers as well as crew members gives students insights into not only possible career paths, but the vital importance of cutting edge oceanographic research on our society. With their science teacher on the ship as an education outreach specialist or ashore guiding students in their interactions with selected scientists at sea, students observe shipboard research being carried out live via videoconference, Skype, daily e-mails, interviews, digital whiteboard sessions, and web interaction. Students then research, design, develop, deploy, and field-test their own data-collecting physical oceanography instruments in their classroom. The online interactive curriculum encourages active inquiry with intellectually stimulating problem- solving, enabling students to gain critical insight and skill while investigating some of

  1. 12th International Conference on Intelligent Information Hiding and Multimedia Signal Processing

    CERN Document Server

    Tsai, Pei-Wei; Huang, Hsiang-Cheh

    2017-01-01

    This volume of Smart Innovation, Systems and Technologies contains accepted papers presented in IIH-MSP-2016, the 12th International Conference on Intelligent Information Hiding and Multimedia Signal Processing. The conference this year was technically co-sponsored by Tainan Chapter of IEEE Signal Processing Society, Fujian University of Technology, Chaoyang University of Technology, Taiwan Association for Web Intelligence Consortium, Fujian Provincial Key Laboratory of Big Data Mining and Applications (Fujian University of Technology), and Harbin Institute of Technology Shenzhen Graduate School. IIH-MSP 2016 is held in 21-23, November, 2016 in Kaohsiung, Taiwan. The conference is an international forum for the researchers and professionals in all areas of information hiding and multimedia signal processing. .

  2. Interleukin-12 induces a Th1-like response to Burkholderia mallei and limited protection in BALB/c mice.

    Science.gov (United States)

    Amemiya, Kei; Meyers, Jennifer L; Trevino, Sylvia R; Chanh, Tran C; Norris, Sarah L; Waag, David M

    2006-02-27

    We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-gamma production by splenocytes from mice that received B. mallei and IL-12. We saw an increase in survivors in the groups of mice that received B. mallei and IL-12 when challenged, compared to mice that received only B. mallei or IL-12. The results suggest that IL-12 can enhance the Th1-like immune response to B. mallei and mediate limited protection from a lethal challenge.

  3. Advances in neutron capture therapy 2006. Proceedings of 12th international congress on neutron capture therapy

    International Nuclear Information System (INIS)

    Nakagawa, Yoshinobu; Kobayashi, Tooru; Fukuda, Hiroshi

    2006-01-01

    The Twelfth International Congress on Neutron Capture Therapy (ICNCT-12) is being held from October 9th to 13th, 2006 at the Kagawa International Congress Hall in Takamatsu, Kagawa, Japan. The main theme of the congress is From the past to the Future'. Five symposiums were organized to accommodate all the contributions from the international scientific committees of the International Society for Neutron Capture Therapy (ISNCT), and two symposiums were added to balance the number of fields of specialties. The seven symposiums for ICNCT-12 are as follows: 1) Clinical Results of BNCT for Brain Tumors, 2) Dosimetry, 3) Treatment Planning system, 4) Drug Delivery System, 5) Biomedical and General Matters, 6) BNCT Systems using Accelerators, 7) New Applications and Protocols for BNCT. There are a total of 195 presentations in this congress: 3 special lectures, 34 symposium presentations, 10 presentations in two special sessions from the recipients of the Ralph G. Fairchild Award, 70 presentations in the oral parallel sessions and 78 presentations in the poster sessions. A compilation of 169 papers are published in this proceedings. The 165 of the presented papers are indexed individually. (J.P.N.)

  4. The impact of financial institutions on the development of the Byzantine economy (10th-12th centuries

    Directory of Open Access Journals (Sweden)

    Maniatis George C.

    2016-01-01

    Full Text Available This article attempts to ascertain the nature of the financial institutions fashioned diachronically to ensure the orderly operation of the Byzantine economy, encompassing the currency in circulation, credit availability, and the nexus of financial services; to analyze their role and evolution over time; to examine their ability to make rational use of the available financial resources; and ultimately to assess their contribution in ensuring the effective functioning of the marketplace and the economy in the 10th-12th centuries. Emphasis is placed on the effectiveness of the monetary system in providing the requisite liquidity to meet the needs of the productive sectors of the economy; the determining factors of money supply and its sectorial penetration; the measures taken to prevent hoarding and alleviate the gold-dependence of the fiscus; the functional distinction between money-changing and moneylending and its rationale; the rules established for the orderly conduct of currency transactions to prevent unsavory practices; the participants involved in lending operations and the extent of market competition; the importance of credit (and hence debt financing in promoting agriculture, manufacturing, and trade; and the role of the state in safeguarding the soundness of the monetary system, banking services, deals in precious metals and valuables, and in the pricing of capital. Moreover, the paper addresses collateral issues in dispute providing more cogent answers, identifies misinterpreted sources and unsupported assertions, and fills in lacunae. It is hoped that the searching examination of the design and operation of the enacted financial institutional arrangements will provide valuable insights as to their genesis, adaptation over time, and likely performance in light of the Byzantine economic, social and political realities.

  5. Stable T-bet+GATA-3+ Th1/Th2 Hybrid Cells Arise In Vivo, Can Develop Directly from Naive Precursors, and Limit Immunopathologic Inflammation

    Science.gov (United States)

    Peine, Michael; Fröhlich, Anja; Hegazy, Ahmed N.; Kühl, Anja A.; Grevelding, Christoph G.; Höfer, Thomas; Hartmann, Susanne; Löhning, Max

    2013-01-01

    Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges. Here we show that natural primary immune responses against parasites generate bifunctional Th1 and Th2 hybrid cells that co-express the lineage-specifying transcription factors T-bet and GATA-3 and co-produce Th1 and Th2 cytokines. The integration of Th1-promoting interferon (IFN)-γ and interleukin (IL)-12 signals together with Th2-favoring IL-4 signals commits naive Th cells directly and homogeneously to the hybrid Th1/2 phenotype. Specifically, IFN-γ signals are essential for T-bet+GATA-3+ cells to develop in vitro and in vivo by breaking the dominance of IL-4 over IL-12 signals. The hybrid Th1/2 phenotype is stably maintained in memory cells in vivo for months. It resists reprogramming into classic Th1 or Th2 cells by Th1- or Th2-promoting stimuli, which rather induce quantitative modulations of the combined Th1 and Th2 programs without abolishing either. The hybrid phenotype is associated with intermediate manifestations of both Th1 and Th2 cell properties. Consistently, hybrid Th1/2 cells support inflammatory type-1 and type-2 immune responses but cause less immunopathology than Th1 and Th2 cells, respectively. Thus, we propose the self-limitation of effector T cells based on the stable cell-intrinsic balance of two opposing differentiation programs as a novel concept of how the immune system can prevent excessive inflammation. PMID:23976880

  6. Stable T-bet(+GATA-3(+ Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.

    Directory of Open Access Journals (Sweden)

    Michael Peine

    Full Text Available Differentiated T helper (Th cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges. Here we show that natural primary immune responses against parasites generate bifunctional Th1 and Th2 hybrid cells that co-express the lineage-specifying transcription factors T-bet and GATA-3 and co-produce Th1 and Th2 cytokines. The integration of Th1-promoting interferon (IFN-γ and interleukin (IL-12 signals together with Th2-favoring IL-4 signals commits naive Th cells directly and homogeneously to the hybrid Th1/2 phenotype. Specifically, IFN-γ signals are essential for T-bet(+GATA-3(+ cells to develop in vitro and in vivo by breaking the dominance of IL-4 over IL-12 signals. The hybrid Th1/2 phenotype is stably maintained in memory cells in vivo for months. It resists reprogramming into classic Th1 or Th2 cells by Th1- or Th2-promoting stimuli, which rather induce quantitative modulations of the combined Th1 and Th2 programs without abolishing either. The hybrid phenotype is associated with intermediate manifestations of both Th1 and Th2 cell properties. Consistently, hybrid Th1/2 cells support inflammatory type-1 and type-2 immune responses but cause less immunopathology than Th1 and Th2 cells, respectively. Thus, we propose the self-limitation of effector T cells based on the stable cell-intrinsic balance of two opposing differentiation programs as a novel concept of how the immune system can prevent excessive inflammation.

  7. Human Brain Proteome Project - 12th HUPO BPP Workshop. 26 September 2009, Toronto, Canada.

    Science.gov (United States)

    Gröttrup, Bernd; Eisenacher, Martin; Stephan, Christian; Marcus, Katrin; Lee, Bonghee; Meyer, Helmut E; Park, Young Mok

    2010-06-01

    The HUPO Brain Proteome Project (HUPO BPP) held its 12th workshop in Toronto on 26 September 2009 prior to the HUPO VIII World Congress. The principal aim of this project is to obtain a better understanding of neurodiseases and ageing, with the ultimate objective of discovering prognostic and diagnostic biomarkers, in addition to the development of novel diagnostic techniques and new medications. The attendees came together to discuss progress in the human clinical neuroproteomics and to define the needs and guidelines required for more advanced proteomic approaches.

  8. The 12th International ICIT Conference Progress in Cryogenics and Isotopes Separation. Proceedings

    International Nuclear Information System (INIS)

    Stefanescu, Ioan

    2006-01-01

    The proceedings of the 12th International ICIT Conference Progress in Cryogenics and Isotopes Separation held in Caciulata, Romania on 25-27 October 2006 contain plenary lectures (11 papers) and 7 sections addressing the following subject matters: Section 1. Stable Isotopes Physics. Technologies and Applications (6 papers); Section 2. Cryogenics Technologies and Equipment (6 papers); Section 3. Science and Materials Engineering (18 papers); Section 4. Nuclear Power (17 papers); Section 5. Hydrogen and Fuel Cells (14 papers); Section 6. Environmental Protection. Industrial Risk (14 papers); Section 7. Laboratory Analysis Methods (13 papers). A number of 40 papers are available in abstract form only and accordingly full text entered the corresponding records

  9. Protocolo de Observação Comportamental - PROC: valores de referência para uma análise quantitativa Behavioral Observation Protocol: reference values for a quantitative analysis

    Directory of Open Access Journals (Sweden)

    Simone Rocha de Vasconcellos Hage

    2012-08-01

    Full Text Available OBJETIVO: obter valores de referência para protocolo de observação comportamental (PROC sobre o desenvolvimento de habilidades comunicativas e de esquemas simbólicos em crianças com desenvolvimento típico de linguagem. MÉTODO: foram avaliadas 44 crianças entre 24 e 47 meses de ambos os gêneros, selecionadas em escolas de educação infantil, por meio de triagem do desenvolvimento global Denver II e questionário com os pais. Todas as crianças foram filmadas durante 30 minutos em interação com um adulto em atividade envolvendo brinquedos. As gravações foram analisadas por meio do PROC. A análise estatística descreveu valores de média, mediana, valores mínimos e máximos. Foi utilizado o teste T de Student para comparação das idades. RESULTADOS: nas habilidades comunicativas, as crianças do estudo mostraram evolução com a idade (média para três e dois anos, respectivamente: 58,12 e 51,44, apesar de não ter sido encontrada diferença estatisticamente significante para as faixas etárias comparadas (p=0,486. Quanto ao item compreensão verbal, as crianças de três anos obtiveram melhor desempenho que as de dois (respectivas médias: 59,41 e 50,70, havendo diferença estatisticamente significante (p=0,0000020. Em relação ao item aspectos do desenvolvimento cognitivo, as crianças de três anos apresentaram melhor desempenho em comparação com as de dois (respectivas médias: 44,53 e 31,96, havendo diferença estatisticamente significante entre as pontuações obtidas (p=0,00364, mostrando que as crianças evoluem na hierarquia do simbolismo. CONCLUSÃO: a obtenção de valores de referência para o PROC veio combinar análise qualitativa e quantitativa, contribuindo, além do diagnóstico, para o acompanhamento objetivo de processos terapêuticos.PURPOSE: to obtain reference values for behavioral observation protocol on the development of communicative and symbolic schemes of children with typical language development

  10. “I” of the author of the 12th century: rhetoric and subjectivity of medieval literature

    Directory of Open Access Journals (Sweden)

    Dolgorukova Natalia Mikhailovna

    2015-10-01

    Full Text Available This article attempts to answer a series of questions relevant to the study of medieval literature: is it possible to create a typology of the medieval “I” and to distinguish rhetorical use of personal constructions from more subjective types which was the author's “I” in the 12th century. Is it possible to talk about subjectivity of medieval literature, and, if so, how is it expressed?

  11. Thorium Th

    International Nuclear Information System (INIS)

    Busev, A.I.; Tiptsova, V.G.; Ivanov, V.M.

    1978-01-01

    The basic methods for extracting thorium from monazites and determining it photometrically and complexometrically are described. Monazite is decomposed by fusion with sodium peroxide, then thorium and the totality of lanthanides are precipitated in the form of oxalates. After the oxalates have been broken down, thorium is determined photometrically with the aid of arsenazo 1, quercetin of 1-2(-pyridylazo)-resorcin. It takes 25 to 30 minutes to photometrically determine Th in monazites with the aid of arsenazo 2 (error: 3 to 5%). Arsenazo 2 is recommended for analysis of monazites containing 20 to 30% of lanthanides. Arsenazo 3 permits determining Th in zircon and in Nb-containing materials. In this case, the determination is possible in strongly acidic solutions, the ratio of arsenazo 3 to Th being 7.5:1. Arsenazo 3 can also be used in determining trace amounts of Th (1x10 -5 to 1x10 -4 %) in rocks, as well as in extraction-photometric determination of Th traces. The dyed compound of Th with arsenazo 3 is extracted with isoamyl alcohol in the presence of diphenylguanidinium chloride and monochloroacetic acid. The method permits determining Th at 1:5x10 8 (0.002 g/ml) dilution. Also described is the iodate-complexometric method for determining Th

  12. 12th International Conference on Informatics in Control, Automation and Robotics

    CERN Document Server

    Madani, Kurosh; Gusikhin, Oleg; Sasiadek, Jurek

    2016-01-01

    The present book includes a set of selected extended papers from the 12th International Conference on Informatics in Control, Automation and Robotics (ICINCO 2015), held in Colmar, France, from 21 to 23 July 2015. The conference brought together researchers, engineers and practitioners interested in the application of informatics to Control, Automation and Robotics. Four simultaneous tracks will be held, covering Intelligent Control Systems, Optimization, Robotics, Automation, Signal Processing, Sensors, Systems Modelling and Control, and Industrial Engineering, Production and Management. Informatics applications are pervasive in many areas of Control, Automation and Robotics. ICINCO 2015 received 214 submissions, from 42 countries, in all continents. After a double blind paper review performed by the Program Committee, 14% were accepted as full papers and thus selected for oral presentation. Additional papers were accepted as short papers and posters. A further selection was made after the Conference, based ...

  13. Chilean 12th graders’ Attitudes towards English as a Foreign Language

    Directory of Open Access Journals (Sweden)

    Eric Gómez Burgos

    2015-10-01

    Full Text Available This article aims to provide the results of a research focusing on 12th graders’ attitudes towards English as a Foreign Language in two secondary schools in Puerto Montt, Chile. Attitude towards a language has been considered as an important factor that influences the process of learning a foreign language (Shams, 2008; for this reason, it is fundamental to identify students’ attitudes since positive attitudes towards English allow the students to have favourable orientation towards learning it (Karahan, 2007. Under this premise, this study corresponds to a case study that includes a quantitative method of data analysis. A survey of five dimensions was conducted amongst 154 students in order to measure their attitudes towards the target language. The results show that their attitudes towards English as a foreign language are favourable; however, the dimensions related to learning English, and English as a subject at school obtained unfavourable attitudes.

  14. spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization.

    Science.gov (United States)

    Wu, Shu-Yan; Wang, Li-Dan; Xu, Guang-Mei; Yang, Si-di; Deng, Qi-Feng; Li, Yuan-Yuan; Huang, Rui

    2017-08-01

    Salmonella enterica serovar typhimurium (S. typhimurium) are facultative intracellular enteric pathogens causing disease with a broad range of hosts. It was known that Th1-type cytokines such as IFN-γ, IL-12, and TNF-α etc. could induce protective immunity against intracellular pathogens, while Th2-type cytokines such as IL-4, IL-10, and IL-13 etc. are proved to help pathogens survive inside hosts and cause severe infection. One of the critical virulence factor attributes to the pathogenesis of S. typhimurium is Salmonella plasmid virulence genes (spv). Until now, the interaction between spv locus and the predictable generation of Th1 or Th2 immune responses to Salmonella has not been identified. In this study, zebrafish adults were employed to explore the effect of spv locus on Salmonella pathogenesis as well as host adaptive immune responses especially shift of Th1/Th2 balance. The pathological changes of intestines and livers in zebrafish were observed by hematoxylin-eosin (HE) staining and electron microscopy. Levels of the transcription factors of Th1 (Tbx21) and Th2 (GATA3) were measured by real-time quantitative PCR (RT-qPCR). Expression of cytokines were determined by using RT-qPCR and ELISA, respectively. Results showed that spv operon aggravates damage of zebrafish. Furthermore, it demonstrated that spv locus could inhibit the transcription of tbx21 gene and suppress the expression of cytokines IFN-γ, IL-12 and TNF-α. On the contrary, the transcription of gata3 gene could be promoted and the expression of cytokines IL-4, IL-10 and IL-13 were enhanced by spv locus. Taken together, our data revealed that spv locus could aggravate Salmonella infection of zebrafish adult by inducing an imbalance of Th1/Th2 immune response and resulting in a detrimental Th2 bias of host. Copyright © 2017. Published by Elsevier Ltd.

  15. Neutron radiative capture cross section of 232Th in the energy range 0.1 to 1.2 MeV

    International Nuclear Information System (INIS)

    Jain, H.M.; Kailas, S.

    1987-01-01

    Recently reported neutron radiative capture cross section of 232 Th measurements in the energy range 0.1 to 1.2 MeV are compared with the calculations based on the statistical model Hauser-Feshbach theory using the spherical optical model transmission coefficients and simple Fermi gas level density formula. The calculations are in good agreement with the recent experimental data, reproducing both the absolute magnitude and the shape exhibited by the excitation function. The results of this comparative study can be used for improving the evaluation of the neutron radiative capture cross section of 232 Th. 16 refs., 3 tables, 4 figures. (author)

  16. Neutron radiative capture cross section of 232Th in the energy range 0.1 to 1.2 MeV

    International Nuclear Information System (INIS)

    Jain, H.M.; Kailas, S.

    1987-03-01

    Recently reported neutron radiative capture cross section of Th-232 measurements in the energy range 0.1 to 1.2 MeV are compared with the calculations based on the statistical model Hauser-Feshbach theory using the spherical optical model transmission coefficients and simple Fermi gas level density formula. The calculations are in good agreement with the recent experimental data, reproducing both the absolute magnitude and the shape exhibited by the excitation function. The results of this comparative study can be used for improving the evaluation of the neutron radiative capture cross section of Th-232. (author)

  17. Service-Oriented Access Control

    Science.gov (United States)

    2014-09-01

    root bridge for each VLAN, all such that traffic cost is minimized. Sung et al. define this cost as the sum of broadcast traffic, inter-VLAN data...Merlin,” in Proc. 12th ACM Workshop on Hot Topics in Networks, College Park, MD, 2013, pp. 24:1–24:7. [10] A. Voellmy and P. Hudak, “ Nettle : Taking the

  18. 12th ACIS/IEEE International Conference on Computer Science and Information Science

    CERN Document Server

    2013-01-01

    This edited book presents scientific results of the 12th IEEE/ACIS International Conference on Computer and Information Science (ICIS 2013) which was held on June 16-20, 2013 in Toki Messe, Niigata, Japan. The aim of this conference was to bring together scientists, engineers, computer users, and students to share their experiences and exchange new ideas, research results about all aspects (theory, applications and tools) of computer and information science, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them The conference organizers selected the best 20 papers from those papers accepted for presentation at the conference. The papers were chosen based on review scores submitted by members of the program committee, and underwent further rigorous rounds of review.    

  19. Award-winning articles and posters from the World Federation of Chiropractic's 12th Biennial Congress 2013.

    Science.gov (United States)

    Haldeman, Scott; Chapman-Smith, David

    2014-01-01

    This editorial reviews the original research submissions to the World Federation of Chiropractic's 12th Biennial Congress held in Durban, South Africa from April 10 - 13, 2013, and the four award-winning scientific articles in the NCMIC Louis Sportelli Research Awards competition at the Congress which are published in this issue of the Journal of Manipulative and Physiological Therapeutics. Copyright © 2014 National University of Health Sciences. Published by Mosby, Inc. All rights reserved.

  20. LIGHT Is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major.

    Science.gov (United States)

    Xu, Guilian; Liu, Dong; Okwor, Ifeoma; Wang, Yang; Korner, Heinrich; Kung, Sam K P; Fu, Yang-Xin; Uzonna, Jude E

    2007-11-15

    Although studies indicate LIGHT (lymphotoxin (LT)-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) enhances inflammation and T cell-mediated immunity, the mechanisms involved in this process remain obscure. In this study, we assessed the role of LIGHT in IL-12 production and development of CD4(+) Th cells type one (Th1) in vivo. Bone marrow-derived dendritic cells from LIGHT(-/-) mice were severely impaired in IL-12p40 production following IFN-gamma and LPS stimulation in vitro. Furthermore, blockade of LIGHT in vitro and in vivo with HVEM-Ig and LT beta receptor (LTbetaR)-Ig leads to impaired IL-12 production and defective polyclonal and Ag-specific IFN-gamma production in vivo. In an infection model, injection of HVEM-Ig or LTbetaR-Ig into the usually resistant C57BL/6 mice results in defective IL-12 and IFN-gamma production and severe susceptibility to Leishmania major that was reversed by rIL-12 treatment. This striking susceptibility to L. major in mice injected with HVEM-Ig or LTbetaR-Ig was also reproduced in LIGHT(-/-) --> RAG1(-/-) chimeric mice. In contrast, L. major-infected LTbeta(-/-) mice do not develop acute disease, suggesting that the effect of LTbetaR-Ig is not due to blockade of membrane LT (LTalpha1beta2) signaling. Collectively, our data show that LIGHT plays a critical role for optimal IL-12 production by DC and the development of IFN-gamma-producing CD4(+) Th1 cells and its blockade results in severe susceptibility to Leishmania major.

  1. A 12-Fold ThSi2 Interpenetrated Network Utilizing a Glycine-Based Pseudopeptidic Ligand

    Directory of Open Access Journals (Sweden)

    Edward Loukopoulos

    2018-01-01

    Full Text Available We report the synthesis and characterization of a 3D Cu(II coordination polymer, [Cu3(L12(H2O8]·8H2O (1, with the use of a glycine-based tripodal pseudopeptidic ligand (H3L1 = N,N′,N″-tris(carboxymethyl-1,3,5-benzenetricarboxamide or trimesoyl-tris-glycine. This compound presents the first example of a 12-fold interpenetrated ThSi2 (ths net. We attempt to justify the unique topology of 1 through a systematic comparison of the synthetic parameters in all reported structures with H3L1 and similar tripodal pseudopeptidic ligands. We additionally explore the catalytic potential of 1 in the A3 coupling reaction for the synthesis of propargylamines. The compound acts as a very good heterogeneous catalyst with yields up to 99% and loadings as low as 3 mol %.

  2. Human Blood CD1c+ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4+ T Cells.

    Science.gov (United States)

    Leal Rojas, Ingrid M; Mok, Wai-Hong; Pearson, Frances E; Minoda, Yoshihito; Kenna, Tony J; Barnard, Ross T; Radford, Kristen J

    2017-01-01

    Dendritic cells (DC) initiate the differentiation of CD4 + helper T cells into effector cells including Th1 and Th17 responses that play an important role in inflammation and autoimmune disease pathogenesis. In mice, Th1 and Th17 responses are regulated by different conventional (c) DC subsets, with cDC1 being the main producers of IL-12p70 and inducers of Th1 responses, while cDC2 produce IL-23 to promote Th17 responses. The role that human DC subsets play in memory CD4 + T cell activation is not known. This study investigated production of Th1 promoting cytokine IL-12p70, and Th17 promoting cytokines, IL-1β, IL-6, and IL-23, by human blood monocytes, CD1c + DC, CD141 + DC, and plasmacytoid DC and examined their ability to induce Th1 and Th17 responses in memory CD4 + T cells. Human CD1c + DC produced IL-12p70, IL-1β, IL-6, and IL-23 in response to R848 combined with LPS or poly I:C. CD141 + DC were also capable of producing IL-12p70 and IL-23 but were not as proficient as CD1c + DC. Activated CD1c + DC were endowed with the capacity to promote both Th1 and Th17 effector function in memory CD4 + T cells, characterized by high production of interferon-γ, IL-17A, IL-17F, IL-21, and IL-22. These findings support a role for CD1c + DC in autoimmune inflammation where Th1/Th17 responses play an important role in disease pathogenesis.

  3. 12th Europhysical Conference on Defects in Insulating Materials (EURODIM 2014)

    International Nuclear Information System (INIS)

    Alfredsson, M L; Chadwick, A V; Jackson, R A; McCabe, E E

    2015-01-01

    The 12th Europhysical Conference on Defects in Insulating Materials (EURODIM14) was held at the University of Kent, UK, from 13-18 July 2014. It was attended by about 120 delegates from around the world, and featured 56 oral presentations and 77 posters. EURODIM14 followed other conferences in the series, held in Pecs (2010), Milan (2006) and Wroclaw (2002), as well as the related ICDIM conferences held in Santa Fe (2012), Aracaju (2008) and Riga (2004). These conferences all have the aim of bringing together scientists to discuss the chemistry and physics of defects in solids, and their role in determining material properties. We would like to thank the International Advisory Committee for suggesting invited speakers, and the Local and Programme Committee for their hard work in planning and running the conference. Finally we would like to thank the authors and referees for their contributions to the proceedings. M L Alfredsson (Conference Chair) A V Chadwick R A Jackson E E McCabe (preface)

  4. Procédé de l'étude de la rupture des fibres à partir d'un essai en ...

    African Journals Online (AJOL)

    Le travail consiste à solliciter en traction des mèches de fibres de verre, en utilisant l'émission acoustique pour suivre en temps réel l'endommagement du matériau. En effet, les ... Deux types d'essais doivent être réalisés, ceci afin de pouvoir comparer les méthodes et les résultats avec ceux déjà obtenus. La procédure ...

  5. Abstracts of the communications presented during the 6th World Rabbit Congress: REPRODUCTION & REPRODUCTION PHYSIOLOGY. Toulouse, July 9-12, 1996

    OpenAIRE

    REPRODUCTION & REPRODUCTION PHYSIOLOGY

    1996-01-01

    Abstract not available. REPRODUCTION & REPRODUCTION PHYSIOLOGY (1996). Abstracts of the communications presented during the 6th World Rabbit Congress: REPRODUCTION & REPRODUCTION PHYSIOLOGY. Toulouse, July 9-12, 1996. World Rabbit Science. 58-67. doi:10.4995/wrs.1996.302 58 67 04

  6. Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes

    Directory of Open Access Journals (Sweden)

    Salma Y Abo Elnazar

    2015-03-01

    Full Text Available Although UV radiation is used to treat several diseases, including rickets, psoriasis, eczema and jaundice, prolonged human exposure to UV radiation may result in acute and chronic health effects on the skin, eye and immune system. Aim: this study is carried out to show the effect of UV on both splenocyte lymphoproliferative response and their capacity to produce IL-12 and IL-10 in mice. Methods: mice were exposed to whole body UVB and tested for the effect of recovery times on splenocyte proliferation and cytokine production. In addition, direct irradiation of spleens and lymphocyte suspension was done. Basal and mitogen-stimulated splenocyte proliferation was assessed by MTT assay while IL-10 and IL-12 were measured using ELISA. Results showed significant suppression in splenocyte proliferation in comparison with control. IL-12 levels were significantly reduced while IL-10 was increased. ConA and PWM had no significant changes in IL-10 while Con A caused a highly significant increase in IL-12 at day six recovery in UVB body irradiation. Conclusion: Exposure to UVB radiation could cause a state of immune suppression and shifts Th1/Th2 cell response. This effect is closely associated with the reduction of Th1 cytokines' expression and increase in Th2 cytokines' levels.

  7. ‘When Going to Saint James’: An Old Russian Graffito from the 12th Century in Aquitania

    Directory of Open Access Journals (Sweden)

    Alexander M. Gordin

    2016-08-01

    Full Text Available In 2015 in Pons, in the former province of Saintonge, an Old Russian pilgrim graffito was found on the wall of the parish church of St. Vivien, a monument of the mid-12th century. It is the second graffito found in France after the one discovered at St. Gilles Abbey. The town of Pons is located on the westernmost route of Santiago de Compostela (via Turonensis and is noteworthy because of the preserved pilgrim almshouse of the latter half of the 12th century. On the walls of its long archway are horseshoe drawings made by medieval pilgrims, the latest of which, dating from the 16th–17th centuries, bends around a name that is also apparently written in Cyrillic script. The earlier inscription, which appears at the base of the northern end wall of the original façade of the St. Vivien church, is made in the name of one Ivan Zavidovich: “Ivano ps[а]lo Zavi|doviche ida ko | svętomu Ię|kovu” (= ‘Ivan Zavidovich wrote this when going to Saint James’. The most probable palaeographic dating is in the 1160s–1180s. As suggested by birch bark manuscripts, the name of Ivan’s father, Zavid, was popular among Novgorod boyars. Novgorod is also the place with the greatest indirect evidence of the occurrence in Old Russia of the western cult of St. James. This well preserved inscription is an important epigraphic discovery, but its main value lies in the direct evidence of pilgrimages by Russians to the shrine of St. James in Galicia.

  8. PREFACE: 12th Conference on ''Theoretical Nuclear Physics in Italy''

    Science.gov (United States)

    Bombaci, I.; Covello, A.; Marcucci, L. E.; Rosati, S.

    2009-07-01

    These Proceedings contain the invited and contributed papers presented at the 12th Conference on Theoretical Nuclear Physics in Italy held in Cortona, Italy, from 8-10 October 2008. As usual, the meeting was held at il Palazzone, a 16th century castle owned by the Scuola Normale Superiore di Pisa. The aim of this biennal conference is to bring together Italian theorists working in various fields of Nuclear Physics to discuss their latest results and confront their points of view in a lively and informal way. This offers the opportunity to promote collaborations between different groups. There were about 50 participants at the conference, coming from 14 Italian Universities (Cagliari, Catania, Ferrara, Firenze, Genova, Lecce, Milano, Napoli, Padova, Pavia, Pisa, Roma, Trento, Trieste). The program of the conference, prepared by the Organizing Committee (Ignazio Bombaci, Aldo Covello, Laura Elisa Marcucci and Sergio Rosati) focused on six main topics: Few-Nucleon Systems, Nuclear Matter and Nuclear Dynamics, Nuclear Astrophysics, Structure of Hadrons and Hadronic Matter, Nuclear Structure, Nuclear Physics with Electroweak Probes. Winfried Leidemann, Maria Colonna, Marcello Lissia, Elena Santopinto, Silvia Lenzi and Omar Benhar took the burden of giving general talks on these topics and reviewing the research activities of the various Italian groups. In addition, 19 contributed papers were presented, most of them by young participants. In the last session of the Conference there were two invited talks related to experimental activities of great current interest. Gianfranco Prete from the Laboratori Nazionali di Legnaro spoke about the Italian radioactive ion beam facility SPES and the status of the European project EURISOL, while Nicola Colonna from the INFN, Bari, gave an overview of the perspectives of development of fourth-generation nuclear reactors. We would like to thank the authors of the general reports for their hard work in reviewing the main achievements in

  9. Longitudinal Study of Career Cluster Persistence from 8th Grade to 12th Grade with a Focus on the Science, Technology, Engineering, & Math Career Cluster

    Science.gov (United States)

    Wagner, Judson

    Today's technology driven global economy has put pressure on the American education system to produce more students who are prepared for careers in Science, Technology, Engineering, and Math (STEM). Adding to this pressure is the demand for a more diverse workforce that can stimulate the development of new ideas and innovation. This in turn requires more female and under represented minority groups to pursue future careers in STEM. Though STEM careers include many of the highest paid professionals, school systems are dealing with exceptionally high numbers of students, especially female and under represented minorities, who begin but do not persist to STEM degree completion. Using the Expectancy-Value Theory (EVT) framework that attributes student motivation to a combination of intrinsic, utility, and attainment values, this study analyzed readily available survey data to gauge students' career related values. These values were indirectly investigated through a longitudinal approach, spanning five years, on the predictive nature of 8 th grade survey-derived recommendations for students to pursue a future in a particular career cluster. Using logistic regression analysis, it was determined that this 8 th grade data, particularly in STEM, provides significantly high probabilities of a 12th grader's average grade, SAT-Math score, the math and science elective courses they take, and most importantly, interest in the same career cluster.

  10. Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

    Science.gov (United States)

    Guimarães, Poliana Macedo; Scavuzzi, Bruna Miglioranza; Stadtlober, Nicole Perugini; Franchi Santos, Lorena Flor da Rosa; Lozovoy, Marcell Alysson Batisti; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Reiche, Edna Maria Vissoci; Maes, Michael; Dichi, Isaias; Simão, Andréa Name Colado

    2017-10-01

    The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

  11. Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.

    Science.gov (United States)

    Kitsiou, Anastasia; Dorbala, Sharmila; Scholte, Arthur J H A

    2015-09-01

    The 12th International Conference on Nuclear Cardiology and Cardiac CT was held from 3 to 5 May 2015 in Madrid, Spain. In this article, the three Congress Program Committee Chairs summarize selected highlights of the presented abstracts. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com. This article is being published concurrently in the Journal of Nuclear Cardiology (10.1007/s12350-015-0260-y) and European Heart Journal – Cardiovascular Imaging (10.1093/ehjci/jev179). The articles are identical except for minor stylistic and spelling differences in keeping with each journal’s style. Either citation can be used when citing this article.

  12. Initiating New Science Partnerships in Rural Education: STEM Graduate Students Bring Current Research into 7th-12th Grade Science Classrooms

    Science.gov (United States)

    Radencic, S.; Dawkins, K. S.; Jackson, B. S.; Walker, R. M.; Schmitz, D.; Pierce, D.; Funderburk, W. K.; McNeal, K.

    2014-12-01

    Initiating New Science Partnerships in Rural Education (INSPIRE), a NSF Graduate K-12 (GK-12) program at Mississippi State University, pairs STEM graduate students with local K-12 teachers to bring new inquiry and technology experiences to the classroom (www.gk12.msstate.edu). The graduate fellows prepare lessons for the students incorporating different facets of their research. The lessons vary in degree of difficulty according to the content covered in the classroom and the grade level of the students. The focus of each lesson is directed toward the individual research of the STEM graduate student using inquiry based designed activities. Scientific instruments that are used in STEM research (e.g. SkyMaster weather stations, GPS, portable SEM, Inclinometer, Soil Moisture Probe, Google Earth, ArcGIS Explorer) are also utilized by K-12 students in the activities developed by the graduate students. Creativity and problem solving skills are sparked by curiosity which leads to the discovery of new information. The graduate students work to enhance their ability to effectively communicate their research to members of society through the creation of research linked classroom activities, enabling the 7-12th grade students to connect basic processes used in STEM research with the required state and national science standards. The graduate students become respected role models for the high school students because of their STEM knowledge base and their passion for their research. Sharing enthusiasm for their chosen STEM field, as well as the application techniques to discover new ideas, the graduate students stimulate the interests of the classroom students and model authentic science process skills while highlighting the relevance of STEM research to K-12 student lives. The measurement of the student attitudes about science is gathered from pre and post interest surveys for the past four years. This partnership allows students, teachers, graduate students, and the public to

  13. Review of the Local Organizing Committee (LOC) medical services during the 12th FINA World Swimming Championships (25 m) in Doha, Qatar.

    Science.gov (United States)

    Dijkstra, H Paul; Geertsema, Liesel; Benzarti, Nejib; van Dorssen, Elsbeth A L; van den Hoogenband, Cees-Rein; Mountjoy, Margo

    2016-05-01

    One of the primary roles of Fédération Internationale de Natation (FINA) is to promote athlete health. The planning and delivery of major international event medical services is carried out in collaboration with the Local Organizing Committee Medical Commission (LOCMC). Aspetar Orthopaedic and Sports Medicine Hospital provided the medical services to the 12th FINA World Swimming Championships (25 m) creating a unique opportunity for collaboration with FINA. The purpose of this paper is to review the planning and delivery of medical services and athlete health promotion projects during the 12th FINA World Swimming Championships (25 m) to facilitate the planning of future sporting events of this size and scope. The 12th FINA World Swimming Championships (25 m) hosted 974 athletes from 166 countries. The LOC medical team recorded all medical encounters-newly incurred (or acute exacerbations of chronic) injuries and illnesses as well as follow-up consultations. More than 90% of teams did not travel with a team physician and relied on the LOCMC for diagnosis and treatment of injuries and illnesses in athletes and accredited team officials. The LOC medical team had a total of 554 medical encounters: 385 therapy, 34 athlete injury, 65 athlete illness and 70 non-athlete encounters. The LOCMC in collaboration with FINA delivered comprehensive medical services to athletes, officials and spectators attending the 12th FINA World Swimming Championships (25 m). This review paper provides information relevant to the planning and delivery of LOCMC medical services for future international swimming events contributing to the FINA objective of promoting athlete health. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. Down-regulation of the Th1, Th17, and Th22 pathways due to anti-TNF-α treatment in psoriasis.

    Science.gov (United States)

    Luan, Li; Han, Shixin; Wang, Hua; Liu, Xiaoming

    2015-12-01

    Psoriasis is a T-cell-mediated chronic inflammatory dermatosis. Th1, Th17 and Th22 cells are suggested to contribute to the pathogenesis of psoriasis. To determine whether treatment with the anti-tumor-necrosis-factor antagonist, adalimumab, induces significant modulation of the Th1, Th17 and Th22 pathways, and correlates cellular activity with clinical response. This study included 21 patients with moderate-to-severe psoriasis who were treated with adalimumab, and 10 healthy control subjects. Blood samples were collected at baseline and at week 12. Flow cytometry was used to analyze the frequency of circulating Th1, Th17 and Th22 cells. Real-time polymerase chain reaction was used to analyze the expression of T-bet (Th1-related), retinoid-acid receptor-related orphan receptor gamma t (RORγt, Th17-related) and aryl hydrocarbon receptor (AHR, Th22-related). An enzyme-linked immunosorbent assay was used to analyze the serum levels of IFN-γ, IL-17, IL-22, IL-6 and tumor necrosis factor-α (TNF-α). At baseline, the frequencies of Th1, Th17 and Th22 cells were higher in psoriasis patients compared to the healthy controls. The expression of transcription factors T-bet, RORγt and AHR, and the serum levels of IFN-γ, IL-17, IL-22, IL-6 and TNF-α were higher in psoriasis patients compared to the healthy controls. After adalimumab therapy, there was a significant decline in the frequencies of Th1, Th17 and Th22 cells, and a concomitant decrease in the levels of their associated transcription factors and cytokines. The results suggest that the anti-tumor-necrosis-factor antagonist, adalimumab, disrupts the Th1, Th17 and Th22 pathways, resulting in clinical improvement of psoriasis. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Changes in the Th1 : Th2 Cytokine Bias in Pregnancy and the Effects of the Anti-Inflammatory Cyclopentenone Prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2

    Directory of Open Access Journals (Sweden)

    Lynne Sykes

    2012-01-01

    Full Text Available Pregnancy is a complex immunological state in which a bias towards T helper 2 (Th2 protects the fetus. Evidence suggests that proinflammatory cytokines increase the risk of poor neonatal outcome, independently of the direct effect of preterm labour. The anti-inflammatory prostaglandin 15-deoxy-Δ12,14-Prostaglandin J2 (15dPGJ2 inhibits nuclear factor Kappa B (NF-κB in amniocytes and myocytes in vitro and is a ligand for the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2 receptor. Here we examine the Th1:Th2 cytokine bias in pregnancy and whether 15dPGJ2 could be used to inhibit the production of the proinflammatory cytokines through inhibition of NF-κB while simultaneously promoting Th2 interleukin 4 (IL-4 synthesis via CRTH2 in T helper cells. Peripheral blood mononuclear cells (PBMCs from women at 28 weeks, term pre-labour, term labour as well as non-pregnant female controls were cultured with 15dPGJ2 or vehicle control and stimulated with phorbol myristyl acetate (PMA/ionomycin. The percentage of CD4+ cells producing interferon gamma (IFN-γ and tumor necrosis factor alpha (TNF-α in response to PMA/ionomycin was significantly reduced in pregnancy. 15dPGJ2 reduced IFN-γ and TNF-α production in stimulated T helper cells, but did not alter IL-4 production in CRTH2+ve cells. 15dPGJ2 also reduced phospho-p65 in stimulated PBMCs. In summary, 15dPGJ2 suppresses the Th1 response of PBMCs during pregnancy and active labour whilst maintaining the Th2 response suggesting a therapeutic benefit in reducing neonatal morbidity in inflammation-induced PTL.

  16. Establishment and evaluation of sex determination method from 12 th thoracic vertebrae based on three-dimensional reconstructed models

    International Nuclear Information System (INIS)

    Guo Ming; Hou Weibin; Jing Yue; Li Youqiong; Zhou Jianying

    2011-01-01

    Objective: To establish the method of using the 12 th vertebrae for sex determination of adult Chinese and evaluate its effect. Methods: The 12 th thoracic vertebrae were developed by the clinic abdomen CT images. A total of 25 linear measurements on 7 aspects of the vertebrae were measured and 4 ratios were calculated. The items were selected which had the significant difference to establish the sex determination equation and its effect was evaluated. Results: Of the total 29 traits, 27 were sexually dimorphic (P<0.05), the accuracy was 56.3% - 89.2%, 8 traits had the accuracies mean or over 80.0%. The trait iVL had the highest accuracy of 89.2%. A function with four variables predicting sex with 90.8% accuracy was derived by using stepwise method of discriminant function analysis: Y=2.98 x iBDsm + 1.97 x PH + 3.37 x BHp + 3.27 x sVL/BHa - 32.80 (mean centroids= -7.69). Conclusion: The method of using the selected traits for sex determination of adult Chinese is practicable and it has a relatively high accuracy. (authors)

  17. 11th Annual Mine Warfare Technology Symposium, May 6-8, 2014 - Monterey, CA

    OpenAIRE

    2014-01-01

    The Naval Postgraduate School (NPS), the Office of Naval Research (ONR), the Program Executive Office Littoral Combat Ships (PEO LCS), OPNAV (N95), and The Consortium for Robotics and Unmanned Systems Education and Research (CRUSER) are pleased to announce the ELEVENTH International Mine Warfare Technology Symposium in Monterey, California, May 6-8, 2014.

  18. Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting The TGFβ/Smad3 pathway.

    Science.gov (United States)

    Luo, Zhenlong; Ji, Yudong; Tian, Dean; Zhang, Yong; Chang, Sheng; Yang, Chao; Zhou, Hongmin; Chen, Zhonghua Klaus

    2018-06-08

    Galectin-7 (Gal-7) has been associated with cell proliferation and apoptosis. It is known that Gal-7 antagonises TGFβ-mediated effects in hepatocytes by interacting with Smad3. Previously, we have demonstrated that Gal-7 is related to CD4+ T cells responses; nevertheless, its effect and functional mechanism on CD4+ T cells responses remain unclear. The murine CD4+ T cells were respectively cultured with Gal-7, anti-CD3/CD28 mAbs, or with anti-CD3/CD28 mAbs & Gal-7. The effects of Gal-7 on proliferation and the phenotypic changes in CD4+ T cells were assessed by flow cytometry. The cytokines from CD4+ T cells were analysed by quantitative real-time PCR. Subcellular localisation and expression of Smad3 were determined by immunofluorescence staining and Western blot, respectively. Gal-7 enhanced the proliferation of activated CD4+ T cells in a dose- and β-galactoside-dependent manner. Additionally, Gal-7 treatment did not change the ratio of Th2 cells in activated CD4+ T cells, while it increased the ratio of Th1 cells. Gal-7 also induced activated CD4+ T cells to produce a higher level of IFN-γ and TNF-α and a lower level of IL-10. Moreover, Gal-7 treatment significantly accelerated nuclear export of Smad3 in activated CD4+ T cells. These results revealed a novel role of Gal-7 in promoting proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting the TGFβ/Smad3 pathway. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. 12th Man in Space Symposium: The Future of Humans in Space. Abstract Volume

    Science.gov (United States)

    1997-01-01

    The National Aeronautics and Space Administration (NASA) is pleased to host the 12th IAA Man in Space Symposium. A truly international forum, this symposium brings together scientists, engineers, and managers interested in all aspects of human space flight to share the most recent research results and space agency planning related to the future of humans in space. As we look out at the universe from our own uniquely human perspective, we see a world that we affect at the same time that it affects us. Our tomorrows are highlighted by the possibilities generated by our knowledge, our drive, and our dreams. This symposium will examine our future in space from the springboard of our achievements.

  20. ES12; The 24th Annual Workshop on Recent Developments in Electronic Structure Theory

    Energy Technology Data Exchange (ETDEWEB)

    Holzwarth, Natalie [Wake Forest Univ., Winston-Salem, NC (United States); Thonhauser, Timo [Wake Forest Univ., Winston-Salem, NC (United States); Salam, Akbar [Wake Forest Univ., Winston-Salem, NC (United States)

    2012-06-29

    ES12: The 24th Annual Workshop on Recent Developments in Electronic Structure Theory was held June 5-8, 2012 at Wake Forest University in Winston-Salem, NC 27109. The program consisted of 24 oral presentations, 70 posters, and 2 panel discussions. The attendance of the Workshop was comparable to or larger than previous workshops and participation was impressively diverse. The 136 participants came from all over the world and included undergraduate students, graduate students, postdoctoral researchers, and senior scientists. The general assessment of the Workshop was extremely positive in terms of the high level of scientific presentations and discussions, and in terms of the schedule, accommodations, and affordability of the meeting.

  1. Proceedings of 12th international workshop on Asian network for accelerator-driven system and nuclear transmutation technology (ADS+NTT 2014)

    International Nuclear Information System (INIS)

    Pyeon, Cheol Ho

    2015-01-01

    The proceedings describe the current status on research and development (R and D) of accelerator-driven system (ADS) and nuclear transmutation techniques (NTT), including nuclear data, accelerator techniques, Pb-Bi target, fuel technologies and reactor physics, in East Asian countries: China, Japan and Korea. The proceedings also include all presentation materials presented in 'the 12th International Workshop on Asian Network for ADS and NTT (ADS+NTT 2014)' held at the Institute of Nuclear Energy and Safety Technology, Chinese Academy of Sciences, Hefei, China on 15th and 16th December, 2014. The objective of this workshop is to make actual progress of ADS R and D especially in East Asian countries, as well as in European countries, through sharing mutual interests and conducting the information exchange each other. The report is composed of these following items: Presentation materials: ADS+NTT 2014. (author)

  2. Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticity.

    Directory of Open Access Journals (Sweden)

    Patricia López

    Full Text Available In this work we analyzed the immune activation properties of different Bifidobacterium strains in order to establish their ability as inductors of specific effector (Th or regulatory (Treg responses. First, we determined the cytokine pattern induced by 21 Bifidobacterium strains in peripheral blood mononuclear cells (PBMCs. Results showed that four Bifidobacterium bifidum strains showed the highest production of IL-17 as well as a poor secretion of IFNγ and TNFα, suggesting a Th17 profile whereas other Bifidobacterium strains exhibited a Th1-suggestive profile. Given the key role of Th17 subsets in mucosal defence, strains suggestive of Th17 responses and the putative Th1 Bifidobacterium breve BM12/11 were selected to stimulate dendritic cells (DC to further determine their capability to induce the differentiation of naïve CD4(+ lymphocytes toward different Th or Treg cells. All selected strains were able to induce phenotypic DC maturation, but showed differences in cytokine stimulation, DC treated with the putative Th17 strains displaying high IL-1β/IL-12 and low IL-12/IL-10 index, whereas BM12/11-DC exhibited the highest IL-12/IL-10 ratio. Differentiation of naïve lymphocytes confirmed Th1 polarization by BM12/11. Unexpectedly, any B. bifidum strain showed significant capability for Th17 generation, and they were able to generate functional Treg, thus suggesting differences between in vivo and vitro responses. In fact, activation of memory lymphocytes present in PBMCS with these bacteria, point out the presence in vivo of specific Th17 cells, supporting the plasticity of Treg/Th17 populations and the key role of commensal bacteria in mucosal tolerance and T cell reprogramming when needed.

  3. Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.

    Science.gov (United States)

    Xing, Zhi-Zhi; Huang, Liu-Ye; Wu, Cheng-Rong; You, Hong; Ma, Hong; Jia, Ji-Dong

    2015-06-21

    To investigate the effects of activated rat hepatic stellate cells (HSCs) on rat Th1/Th2 profile in vitro. Growth and survival of activated HSCs and CD4(+) T lymphocytes cultured alone or together was assessed after 24 or 48 h. CD4(+) T lymphocytes were then cultured with or without activated HSCs for 24 or 48 h and the proportion of Th1 [interferon (IFN)-γ(+)] and Th2 [interleukin (IL)-4(+)] cells was assessed by flow cytometry. Th1 and Th2 cell apoptosis was assessed after 24 h of co-culture using a caspase-3 staining procedure. Differentiation rates of Th1 and Th2 cells from CD4(+) T lymphocytes that were positive for CD25 but did not express IFN-γ or IL-4 were also assessed after 48 h of co-culture with activated HSCs. Galectin-9 expression in HSCs was determined by immunofluorescence and Western blotting. ELISA was performed to assess galectin-9 secretion from activated HSCs. Co-culture of CD4(+) T lymphocytes with activated rat HSCs for 48 h significantly reduced the proportion of Th1 cells compared to culture-alone conditions (-1.73% ± 0.71%; P Th1/Th2 ratio was significantly decreased (-0.44 ± 0.13; P Th1 cells was decreased (-65.71 ± 9.67; P Th1 (12.27% ± 0.99%; P Th1 cell apoptosis rate was significantly higher than in Th2 cells (P Th1 and Th2 cells; however, the increase in the proportion of Th2 cells was significantly higher than that of Th1 cells (1.85% ± 0.48%; P Th1/Th2 profile, inhibiting the Th1 response and enhancing the Th2 response, and this may be a novel pathway for liver fibrogenesis.

  4. Find the fish: using PROC SQL to build a relational database

    Science.gov (United States)

    Fabrizio, Mary C.; Nelson, Scott N.

    1995-01-01

    Reliable estimates of abundance and survival, gained through mark-recapture studies, are necessary to better understand how to manage and restore lake trout populations in the Great Lakes. Working with a 24-year data set from a mark-recapture study conducted in Lake Superior, we attempted to disclose information on tag shedding by examining recaptures of double-tagged fish. The data set consisted of 64,288 observations on fish which had been marked with one or more tags; a subset of these fish had been marked with two tags at initial capture. Although DATA and PROC statements could be used to obtain some of the information we sought, these statements could not be used to extract a complete set of results from the double-tagging experiments. We therefore used SQL processing to create three tables representing the same information but in a fully normalized relational structure. In addition, we created indices to efficiently examine complex relationships among the individual capture records. This approach allowed us to obtain all the information necessary to estimate tag retention through subsequent modeling. We believe that our success with SQL was due in large part to its ability to simultaneosly scan the same table more than once and to permit consideration of other tables in sub-queries.

  5. PREFACE: 12th Europhysical Conference on Defects in Insulating Materials (EURODIM 2014)

    Science.gov (United States)

    Alfredsson, M. L.; Chadwick, A. V.; Jackson, R. A.; McCabe, E. E.

    2015-04-01

    The 12th Europhysical Conference on Defects in Insulating Materials (EURODIM14) was held at the University of Kent, UK, from 13-18 July 2014. It was attended by about 120 delegates from around the world, and featured 56 oral presentations and 77 posters. EURODIM14 followed other conferences in the series, held in Pecs (2010), Milan (2006) and Wroclaw (2002), as well as the related ICDIM conferences held in Santa Fe (2012), Aracaju (2008) and Riga (2004). These conferences all have the aim of bringing together scientists to discuss the chemistry and physics of defects in solids, and their role in determining material properties. We would like to thank the International Advisory Committee for suggesting invited speakers, and the Local and Programme Committee for their hard work in planning and running the conference. Finally we would like to thank the authors and referees for their contributions to the proceedings. M L Alfredsson (Conference Chair) A V Chadwick R A Jackson E E McCabe

  6. Circunferência abdominal avaliada antes da 12ª semana de gestação: correlação com níveis séricos de leptina Waist circumference measured before the 12th week of pregnancy: correlation with serum leptin levels

    Directory of Open Access Journals (Sweden)

    Didier Silveira Castellano Filho

    2012-06-01

    Full Text Available OBJETIVOS: Avaliar a correlação entre a circunferência abdominal materna, medida antes da 12ª semana de gestação, e os níveis séricos de leptina durante a gravidez, bem como, comparar os níveis médios de leptina entre gestantes com e sem obesidade abdominal, diagnosticada no início da gestação. MÉTODOS: Estudo prospectivo incluindo 40 gestantes atendidas no pré-natal de baixo risco, superiores a 20 anos, não tabagistas, com gestação única, e sem doenças crônicas intercorrentes. A circunferência abdominal foi medida antes da 12ª semana, e os níveis séricos de leptina dosados entre a 9ª e a 12ª, a 25ª e a 28ª e entre a 34ª e a 37ª semanas de gestação. De acordo com a circunferência abdominal, a coorte foi dividida em dois grupos: com e sem obesidade abdominal. Os testes de Mann-Whitney e do χ² avaliaram as diferenças entre os grupos. A correlação de Pearson verificou a associação entre a circunferência abdominal e os níveis séricos de leptina durante a gestação. Considerou-se o valor de pPURPOSE: To evaluate the correlation between maternal waist circumference measured before the 12th week of gestation and serum leptin levels during pregnancy, as well as to compare the leptin levels of women with and without abdominal obesity diagnosed in early pregnancy. METHODS: Prospective study including 40 pregnant women receiving low-risk prenatal care, older than 20 years, nonsmokers, with singleton pregnancies and without chronic disease. Waist circumference was measured before the 12th week and serum leptin levels were measured between the 9th and 12th, 25th and 28th and 34th and 37th weeks of gestation. According to waist circumference measurement, the cohort was divided into two groups: with and without abdominal obesity. The Mann-Whitney and χ² tests were used to assess the differences between groups. The Pearson correlation coeffient was used to assess the association between waist circumference and

  7. Composition of 12-18th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

    International Nuclear Information System (INIS)

    Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwe, Danielle

    2007-01-01

    A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th -18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making

  8. Composition of 12-18 th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

    Science.gov (United States)

    Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwé, Danielle

    2007-07-01

    A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th-18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making.

  9. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.

    Science.gov (United States)

    Li, Xia; Wang, Bin; Li, Yuzhu; Wang, Li; Zhao, Xiangzhong; Zhou, Xianbin; Guo, Yuqi; Jiang, Guosheng; Yao, Chengfang

    2013-01-09

    /Treg cells were analyzed using flow cytometry. To evaluate the effect of stachydrine hydrochloride in reducing uterine bleeding via regulation of the Th1/Th2/Th17/Treg paradigm, pregnant mice were treated with RU486 (1.5mg/kg) and/or stachydrine hydrochloride (2.5mg/kg, 5mg/kg, and 10mg/kg). The serum P(4) level, uterine bleeding volume, and proportions of Th1/Th2/Th17/Treg cells at the mice maternal-fetal interface were detected. Moreover, the protein levels of cytokines (IL-12 and IL-6) and the cytokine soluble receptors were analyzed by ELISA assay, and the mRNA expression of transcription factors (T-bet, GATA-3, RORγt, and Foxp3) were detected by RT-PCR assay. Th1- and Th17-biased immunity was observed in RU486-induced abortion mice. The volume of uterine bleeding during RU486-induced abortion was negatively related to the proportions of Th1 and Th17 cells, as well as the ratios of Th1:Th2 cells and Th17:Treg cells, and positively related to the proportions of Th2 and Treg cells. Stachydrine hydrochloride promoted the protein expression of IL-12 and IL-6, as well as the mRNA expression of T-bet and RORγt, while inhibiting the mRNA expression of GATA-3 and Foxp3. Therefore, the Th1/Th2/Th17/Treg paradigm in RU486-induced abortion mice shifted to Th1 and Th17 after stachydrine hydrochloride administration. The volume of uterine bleeding during RU486-induced abortion was reduced significantly after stachydrine hydrochloride administration. The Th1/Th2/Th17/Treg paradigm is closely related to the volume of uterine bleeding in RU486-induced abortion mice. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride contributed to the reduction in uterine bleeding in RU486-induced abortion mice. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  10. 12th CERN-Fermilab Hadron Collider Physics Summer School

    CERN Document Server

    2017-01-01

    CERN and Fermilab are jointly offering a series of "Hadron Collider Physics Summer Schools", to prepare young researchers for these exciting times. The school has alternated between CERN and Fermilab, and will return to CERN for the twelfth edition, from 28th August to 6th September 2017. The CERN-Fermilab Hadron Collider Physics Summer School is an advanced school targeted particularly at young postdocs and senior PhD students working towards the completion of their thesis project, in both Experimental High Energy Physics (HEP) and phenomenology. Other schools, such as the CERN European School of High Energy Physics, may provide more appropriate training for students in experimental HEP who are still working towards their PhDs. Mark your calendar for 28 August - 6 September 2017, when CERN will welcome students to the twelfth CERN-Fermilab Hadron Collider Physics Summer School. The School will include nine days of lectures and discussions, and one free day in the middle of the period. Limited scholarship ...

  11. Sex determination using anthropometric measurements from multi-slice computed tomography of the 12th thoracic and the first lumbar vertebrae among adult Egyptians

    Directory of Open Access Journals (Sweden)

    Fatma M.M. Badr El Dine

    2015-09-01

    Conclusion: Finally, it was concluded that the 12th thoracic vertebra is more accurate for sex determination than the first lumbar vertebra in the Egyptian population, which means that bone dimensions are population specific.

  12. Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus.

    Science.gov (United States)

    Piccinni, M-P; Lombardelli, L; Logiodice, F; Tesi, D; Kullolli, O; Biagiotti, R; Giudizi, Mg; Romagnani, S; Maggi, E; Ficarra, G

    2014-03-01

    The role of Th17 cells and associated cytokines was investigated in oral lichen planus. 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1β, RANTES, IL-4, IL-12B, IL-8, IFN-γ, TNF-α, IL-1α, IL-18, TGF-β1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. Results showed that Th17-type and Th0-type molecules' mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules' mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Selective recruitment of Th I cells induced by re-infection of succeptible and resistant mice with Pseudomonas aerugionosa in the lungs indicates protective role of IL-12

    DEFF Research Database (Denmark)

    Moser, C; Jensen, P O; Kobayashi, O

    2002-01-01

    , resistance to re-infection was paralleled by a shift towards a Th1-dominated response and increased IL-12 production. No significant increase in serum IgG was observed in the re-infected mice. In conclusion, these results indicate a protective role for a Th1-dominated response, independent of antibody...

  14. Reasons for Vaping Among U.S. 12th Graders.

    Science.gov (United States)

    Evans-Polce, Rebecca J; Patrick, Megan E; Lanza, Stephanie T; Miech, Richard A; O'Malley, Patrick M; Johnston, Lloyd D

    2018-04-01

    Vaping has recently increased in popularity among adolescents. Little is known about heterogeneity of vapers, particularly in terms of why they vape. Identifying major subgroups of adolescent vapers by reasons for vaping is important to understand adolescent vaping behavior and to identify those most at risk for other substance use. Monitoring Future data from 2015 and 2016 were used in a latent class analysis to identify subgroups of 12th graders based on their endorsement of 10 potential reasons for vaping. Multinomial regression with a latent class outcome was used to predict class membership. Three distinct classes of vapers were identified: adolescents who were (1) Vaping to Experiment (29.4%), (2) Vaping to Replace Cigarettes (7.3%), and (3) Vaping for Taste + Entertainment (63.4%). Vaping only flavors was associated with lower odds of membership and cigarette use was associated with higher odds of membership in the Vaping to Replace Cigarettes subgroup, and marijuana was associated with lower odds of membership in the Vaping to Experiment subgroup, compared with the Vaping for Taste + Entertainment subgroup. This study identified multiple subgroups of vapers based on reasons for vaping. Whereas a small subgroup vaped for reasons related to cigarette use, most adolescent vapers reported vaping for reasons unrelated to cigarette use. There were considerable differences in primary reasons for vaping and risk for traditional cigarette and other substance use, suggesting different intervention strategies may be needed for different subgroups of vapers. Copyright © 2017 The Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  15. Le procédé du collage dans l’oeuvre de Max Ernst

    Directory of Open Access Journals (Sweden)

    Márcia Maria Valle Arbex

    2011-10-01

    Full Text Available Considerado um dos inventores da colagem, no sentido moderno da palavra, Max Ernst desenvolve a técnica estendendo sua prática e transformando-a em conceito. Nossa reflexão aborda este “recurso” sob ângulo de sua relação com a noção de imagem surrealista, a partir de exemplos de trabalhos executados em 1919-1920, onde as imagens vêm acompanhadas de legendas, formando o que chamamos de poema-duplo.Considéré l’un des créateurs du collage dans le sens moderne du mot, Max Ernst développe cete technique en élargissant sa pratique et en la transformant en concept. Notre réflexion porte sur ce “procédé”, sous l’angle de ses rapports avec la notion d’image poétique surréaliste, à partir d’exemples de travaux réalisés en 1919-1920, où des légendes accompagnent les images formant une sorte poème-double.

  16. 12th meeting of Asian Parliamentarians on Population and Development.

    Science.gov (United States)

    1999-01-01

    At the 12th annual Asian Parliamentarians Meeting on Population and Development, co-sponsored by the Asian Population and Development Association (APDA) of Japan and the Philippine Legislative Committee on Population and Development (PLCPD), the adverse effect of population growth on economic development and the importance of improvements in women's status were central themes. Fukusaburo Maeda, President of APDA Japan, noted that an understanding of women's issues is key to solving global population problems. Numerous participants urged rapid implementation of plans outlined at recent conferences in Cairo and Beijing to empower women and involve them in all stages of the development process. Even issues of food security are linked to women's issues, since women are generally responsible for feeding their families. Participants voted to adopt the "Manila Resolution on Women, Gender, Population, and Development"--a call for social and economic empowerment of women and resources for gender-related programs. Dr. Patricia Licuanan, Chair of the UN Committee on the Status of Women, noted that men should not feel threatened by women holding positions of power; rather, they should welcome an equal partnership between men and women. In her closing address, Senator Leticia Ramos Shahani, Chair of PLCPD, stressed the importance of placing women's empowerment on various parliamentary agendas and commended APDA for its research and population-based surveys in Asia.

  17. Une théorie pour penser les industries culturelles et informationnelles ?

    Directory of Open Access Journals (Sweden)

    Pierre Mœglin

    2012-09-01

    Full Text Available Cet article traite de la naissance et du développement de la théorie des industries culturelles et informationnelles. Il procède des deux questions suivantes : pourquoi une théorie unifiée, plutôt que la juxtaposition de toutes les théorisations ayant accompagné les étapes successives de l’histoire de ces industries et le développement de chacun de leurs secteurs ? Pourquoi une théorie originale, au lieu des approches industrielles proposées, par exemple, par l’économie ou la sociologie ? À ces questions la réponse est, d’une part, que la diversité des appréciations sur les enjeux des industries culturelles et informationnelles et leurs contradictions, d’un auteur à l’auteur, illustre la dimension dialectique du développement des industries culturelles et informationnelles elles-mêmes. D’autre part, la singularité de ces industries justifie le recours à un modèle d’analyse différent du modèle industriel standard.This paper deals with the birth and development of the cultural and informational industries theory. It arises from two questions. First, why one unified theory, rather than juxtaposing the different attempts to understand these industries step by step and sector by sector ? Second, why a specific theory, instead of borrowing from economy or sociology, for instance ? The answer is on the one hand that the contradictions among researchers about the issues of the cultural and informational industries demonstrate in themselves the dialectical nature of their development ; on the other hand, that the specificity of these industries requires an analysis model quite different from the standard model.

  18. Risk is still relevant: Time-varying associations between perceived risk and marijuana use among US 12th grade students from 1991 to 2016.

    Science.gov (United States)

    Terry-McElrath, Yvonne M; O'Malley, Patrick M; Patrick, Megan E; Miech, Richard A

    2017-11-01

    Perceived risk of harm has long been a key preventive factor for adolescent marijuana use. However, in recent years, perceived risk has decreased markedly and marijuana use has increased only slightly, leading to new questions about their association. This study investigates the magnitude and stability of the US adolescent marijuana risk/use association from 1991 to 2016, overall and by gender and race/ethnicity. Self-reported data on past 12-month marijuana use, perceived risk of regular marijuana use, gender, and race/ethnicity were obtained from 275,768 US 12th grade students participating in the nationally representative Monitoring the Future study. Time-varying effect modeling (TVEM) was used to examine the marijuana risk/use association over time. Both before and after controlling for gender and race/ethnicity, perceived risk was a strong protective factor against adolescent marijuana use. The magnitude of the great risk/use association strengthened for Hispanic students; remained generally stable over time for 12th graders overall, males, females, and White students; and weakened for Black students. The magnitude of the moderate risk/use association strengthened for 12th graders overall, males, females, White and Hispanic students, but did not continue to strengthen for Black students from 2005 onwards. In general, marijuana use prevalence decreased over time within all levels of perceived risk. Perceived risk remains a strong protective factor for adolescent marijuana use, and the protective association for moderate risk (vs. no/slight risk) is actually increasing over time. Results suggest that accurate and credible information on the risks associated with marijuana use should remain a key component of prevention efforts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Dynamic stabbing queries with sub-logarithmic local updates for overlapping intervals : Proc. 12th International Computer Science Symposium in Russia

    NARCIS (Netherlands)

    Khramtcova, Elena; Löffler, Maarten

    2017-01-01

    We present a data structure to maintain a set of intervals on the real line subject to fast insertions and deletions of the intervals, stabbing queries, and local updates. Intuitively, a local update replaces an interval by another one of roughly the same size and location. We investigate whether

  20. Modeling of Teaching 5th-7th-Grade Boys Physical Exercises

    Directory of Open Access Journals (Sweden)

    Т. Г. Абдулхалікова

    2017-09-01

    Full Text Available The research objective is to determine the effectiveness of orthogonal variants of teaching 5th-7th graders physical exercises. Materials and methods. The participants in the research were boys of the 5th grade (n = 32, 6th grade (n = 40, 7th grade (n = 52. To achieve the tasks set, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, timing of educational tasks; pedagogical experiment, medical and biological research methods; methods of mathematical statistics, methods of mathematical experiment planning. In order to achieve the objective set, the research has studied the effect of different variants of the educational process structure, namely: the number of repetitions (х1 and rest intervals (х2 when learning the technique of performing physical exercises. The research has conducted a complete factor experiment of type 22. According to the experiment plan, the 5th-7th graders were divided into training groups. In total, there were 12 experimental groups organized. Research results. The analysis of the regression equations shows that the teaching of physical exercises to the 5th-7th-grade boys is mostly influenced by rest intervals between repetitions (х2. The number of repetitions (х1 has somewhat less influence. The interaction of these factors is insignificant when teaching physical exercises and becomes much more influential only when teaching a switch leg pull-over exercise (х1х2. Conclusions. To increase the effectiveness of teaching 5th-7th graders physical exercises, it is necessary to shorten rest intervals between repetition to 60 s and to reduce the number of repetitions to six. When teaching boys the switch leg pull-over exercise, rest intervals should be increased to 120 s and the number of repetitions — to twelve.

  1. Production of 231Pa and 232U by irradiation of 230Th/232Th mixtures

    International Nuclear Information System (INIS)

    Kluge, E.; Lieser, K.H.

    1981-01-01

    The production of 231 Pa and of 232 U by irradiating a 230 Th/ 232 Th mixture (containing 12 mol per cent 230 Th) in form of ThO 2 at a thermal neutron flux of 6.9 x 10 13 cm -2 s -1 for 4 months was investigated. Pa, U and Th were separated and the chemical yields were determined. 2.6% of the 230 Th were transformed into 231 Pa and 0.13% into 232 U. These values are higher than those calculated for a thermal flux, but lower than those calculated for a flux ratio epithermal to thermal = 0.03. 231 Pa and 232 U were isolated in form of a protactinium solution and of U 3 O 8 with 94.9 and 89.1% chemical yields, respectively. Foreign activities were not detected. Thorium was recuperated and isolated as ThO 2 , with a chemical yield of 93.6%. (orig.)

  2. Investigation of normal force and moment coefficients for an AUV at nonlinear angle of attack and sideslip range

    Digital Repository Service at National Institute of Oceanography (India)

    Barros, E.A. de; Dantas, J.L.D.; Pascoal, A.M.; Desa, E.S.

    -dimensional axi-symmetric body,” in Proc. 6th ISOPE Conf., Los Angeles, CA, 1996, vol. II, pp. 256–264. [8] D. Humphreys, “Correlation and validation of a CFD based hydrody- namic & dynamic model for a towed underwater vehicle,” in Proc. MTS/IEEE OCEANS Conf...

  3. Structural phase stability of ThSb and ThAs under pressure

    International Nuclear Information System (INIS)

    Venkatasubramaniam, K.; Rajagopalan, M.; Palanivel, B.; Kalpana, G.

    1997-01-01

    The high-pressure behaviour of thorium monopnictides is of considerable interest as these systems exhibit structural phase transitions under pressure. At ambient conditions these compounds crystallize in the NaCl-type(B1) structure. Experiments show that with the application of pressure these compounds transform to the CsCl-type (B2) structure. ThSb and ThAs are found to exhibit B1-B2 transition in the pressure range between 9-12 GPa and 1826 GPa respectively. In this work, we present the electronic and high-pressure behaviour of ThAs and ThSb performed using the tight-binding linear muffin-tin orbital method. The total energies within the atomic sphere approximation were calculated as a function of volume for both the B1 and B2 structures. The total energy calculations reveal that both ThSb and ThAs are stable in the B1 structure at ambient conditions and undergo structural transition to the B2 structure at pressures 78 and 240 kbar respectively, which are in good agreement with the experimental values. The calculated values of equilibrium lattice parameter and the transition pressure are found to be in good agreement with the experimental results. (author)

  4. [Recent history: 12th International Conference on Cancer, Buenos Aires, Argentina, 1978].

    Science.gov (United States)

    Spinelli, Hugo

    2014-04-01

    Using the approaches of history of the present, this article recovers the discussions surrounding the 12th International Conference on Cancer carried out in Buenos Aires in 1978, in reaction to which Georges Périès organized a "counter-conference" in Paris. In order to understand this discussion, the political situation of the time is described, as is the state of human rights at the time in Argentina, the role of the media - in particular the newspapers La Nación and Clarín and the magazine Gente - and the institutional position adopted by the National Academy of Medicine, as expressed in a letter sent to the presidents of the primary scientific societies of the world. The letter is reprinted in this text as a documentary source, taken from Memoria: Año 1978 (Presidencia de Dr. José E. Rivarola) [Acta: Year 1978 (Presidency of Dr. José E. Rivarola)]. The framework of the discussion makes reference to science's social policy versus science's supposed neutrality and the role of scientific societies.

  5. Innovació en educació. De la idea a l’acció. Procés participatiu cap a l'INNED 2

    Directory of Open Access Journals (Sweden)

    Artur Parcerisa-Aran

    2011-06-01

    Full Text Available Per al progrés de l’educació, la innovació és indispensable. Aquest concepte, que es relaciona però no s’ha de confondre amb el de canvi, no tothom l’entén igual, i això fa que sigui necessari definir quines són les característiques que ha de tenir un procés perquè es pugui considerar una innovació educativa. A partir de la preocupació per ajudar a fer que les innovacions no es quedin només en idees sinó que esdevinguin realitats a les aules i en altres espais educatius, es va engegar un procés de trobades amb professorat i altres educadors i educadores per treballar sobre la innovació educativa de cara a l’organització del II Simposi d’Innovació Educativa (INNED 2. Un dels eixos que va suscitar més interès va ser el de la innovació metodològica. En la part final de l’article es recullen una sèrie de consideracions sobre alguns àmbits que cal considerar en aquesta innovació: la implicació de l’alumnat, l’organització de l’espai i el temps, l’avaluació per aprendre i l’atenció a la diversitat.

  6. Serum levels of Th1/Th2 cytokines in aged patients and their correlation with eczema development and clinical manifestation

    Directory of Open Access Journals (Sweden)

    Wei-Gang Wang

    2016-05-01

    Full Text Available Objective: To investigate variations of Th1/Th2 cytokine levels, as well as their correlation with eczema development and clinical manifestation in aged patients. Methods: A total of 92 patients (above 60 years old with eczema diagnosed by the outpatient department of dermatology and venerology of our hospital were included as the eczema group, while 60 aged patients without eczema as the healthy group. Patients' serum levels of Th1/Th2 cytokines were examined for inter-group comparison and stratified analysis as per clinical manifestation. Results: Serum levels of interleukin (IL-2, IL-4, IL-10, IL-12, tumor necrosis factor (TNF- α and interferon (IFN- γ were all significantly higher in patients of the eczema group than the healthy group. Acute stage levels of IL-2, IL-4, IL-10 and IFN-γ were significantly higher in patients of the eczema group than the healthy group. There was no significant difference in the levels of IL-12 and TNF-α between patients of the acute stage and those of the chronic stage. And no significant difference existed in the levels of IL-2, IL-4, IL-10, IL-12, TNF-α and IFN-γ between generalized and localized eczema patients. Conclusion: Compared with the healthy population, Th1/Th2 cytokine levels are significantly different in eczema patients, especially those in the acute stage.

  7. Procés d’implantació de les HoloLens als boxes de reparació de SEAT, S.A.

    OpenAIRE

    Cano Almazán, Raquel

    2017-01-01

    Aquest treball de final de grau consisteix en la implantació d’una aplicació pertanyent a la Realitat Augmentada a la operativa de les auditories de manguetes del departament de Gestió de Qualitat de Motors i Triebsatz de l’empresa SEAT, S.A. L’aplicació que es vol aconseguir consisteix en un suport per l’auditor per realitzar correctament l’auditoria i per agilitzar el seu procés optimitzant els seus passos. El hardware que s’ha utilitzat per a poder dur a terme la aplicació en qüestió...

  8. The statistical model of origin and evolution planets of Solar system and planetary satellities

    Science.gov (United States)

    Krot, A.

    , Preprint IAC-03-J.1.08. -11p. [12] A.M.Krot , Proc. of 35th COSPAR Scientific Assembly, Paris, France, July 18-25, 2004, Abstract-Nr. COSPAR 04-A-00162. [13] A.Krot, Proc. EGU- 2nd General Assembly, Vienna, Austria, April 24-29, 2005, Geophysical Research Abstracts, vol.7, EGU05-A-04550, 2005; SRef-ID: 1607-7962/gra/. [14] A.Krot Proc. EGU- General Assembly, Vienna, Austria, April 02- 07, 2006, Geophysical Research Abstracts, vol.8, EGU06-A-00216, 2006; SRef-ID: 1607-7962/gra/. 2

  9. TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground.

    Science.gov (United States)

    Beck, Inken M; Sedlacek, Radislav

    2015-02-01

    The 12th Transgenic Technology meeting was held in Edinburgh on 6th-8th October 2014 and interest to participate in the meeting overcame all expectations. The TT2014 was the largest meeting ever with more than 540 scientists, technicians, and students from all over the world. The meeting had an excellent scientific program that brought information on the latest ground-breaking technologies for gene targeting and genome editing using programmable nucleases into the foreground. These presentations were well balanced with several highlights over viewing topics in embryonic stem cell research, embryogenesis, disease models, and animals in agriculture. Ample space was reserved also for short talks presenting technical development and for highlighting posters contributions. A highlight of the meeting was the award of the 10th International Society of Transgenic Technologies Prize to Janet Rossant for her outstanding contributions in the field of mouse embryogenesis.

  10. Foreword: The 12th International Conference on Vibrations at Surfaces (VAS 12) (Erice, 20 26 July 2007)

    Science.gov (United States)

    Benedek, Giorgio; Vattuone, Luca

    2008-06-01

    The 12th International Conference on Vibrations at Surfaces (VAS 12) took place from 20 26 July 2007 as an event of the International School of Solid State Physics at the Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy). The format and special environment of the conference have contributed to its transition from a traditional, medium-size conference into a more effective workshop, with a series of lectures reporting the most recent developments in the field, two poster sessions presenting recent results and even works in progress being discussed. The papers collected in this issue cover the highlights of the conference very thoroughly. Quite a few novel aspects concerning vibrations at surfaces are represented here, for example: new aspects in surface phonon spectroscopy, such as the very recent progress in inelastic x-ray scattering, the first observation of the boson peak in disordered surfaces, progress in the theory of atom scattering inelastic resonances, the action spectroscopy, the study of polycrystalline surfaces with electron energy-loss spectroscopy etc; parallel developments in experimental vibrational studies of adsorbed phases, either inorganic or organic, with those in ab initio theoretical simulations; the theory of enhanced electron--phonon interaction in low dimensions (2D and 1D); the extension from the traditional realm of surface vibrations and spectroscopy to other aspects of surface dynamics, like friction and various nonlinear effects, and to relevant dynamical phenomena occurring at interfaces. Other novelties presented at the conference, but already published in recent issues of the Journal of Physics: Condensed Matter, are also worth mentioning: the spin-echo spectroscopy with 3He allowing for slow-dynamics spectroscopy at very high, unprecedented resolutions (2007 J. Phys.: Cond. Matter 19 300301 and 305010; the first demonstration of dissociative surface trapping of molecules (2007 J. Phys.: Cond. Matter 19

  11. La Numérisation des Thèses en France: Pour une Meilleure Valorisation de la Recherche Scientifique Française

    Directory of Open Access Journals (Sweden)

    Christine Okret

    2000-05-01

    Full Text Available Tels qu’ils existent actuellement, les procédés institutionnels de valorisation des thèses soutenues dans les universités et grands établissements français reposent sur deux circuits concomitants. En premier lieu les thèses soutenues sont déposées sous forme papier dans la bibliothèque de leur université de soutenance, où elles peuvent être consultées sur place, et prêtées par le biais du réseau de prêt entre bibliothèques. En second lieu, un exemplaire papier est transmis aux ateliers nationaux de reproduction des thèses chargés du microfichage des textes et de la diffusion systématique de ces microfiches auprès de toutes les bibliothèques universitaires. Ces deux formes de diffusion non commerciale présentent en regard des exigences des chercheurs trois inconvénients majeurs: la diffusion des thèses est géographiquement restreinte, puisque limitée aux bibliothèques universitaires; le support microfiche est jugé peu convivial; le prêt entre établissements est parfois trop lent ou onéreux, ce qui peut décourager les utilisateurs qui désirent consulter sur papier les thèses non conservées dans leur bibliothèque universitaire.

  12. 12th Industrial Exhibition “Germany at CERN“: 28 and 29 January 2014

    CERN Multimedia

    2013-01-01

    The Federal Ministry of Education and Research (BMBF) together with CERN, will hold the 12th Industrial Exhibition “Germany at CERN”. More than 50 German companies will present their latest products and services, often specifically developed for CERN, to the scientists and buyers of CERN, establishing contacts and providing information about future purchasing opportunities.   Heated tent adjacent to Restaurant 1 Tuesday 28 January 2014 from 11 a.m. to 5.30 p.m. Wednesday 29 January 2014 from 9 a.m. to 5 p.m. On 28 January, MinDir Dr. Karl Eugen Huthmacher, Director for Provision for the Future - Basic and Sustainability Research within the Federal Ministry of Education and Research, and CERN Director-General Professor Rolf D. Heuer will open the exhibition. This will be followed by a tour of the exhibition. Individual meetings between the company representatives and CERN staff can be organised either in the booths in the tent adjacent to Restaurant 1 or in conference...

  13. Peculiarities of Motor Abilities Development in 7th-8th-Graders

    Directory of Open Access Journals (Sweden)

    Ю. В. Мороз

    2015-09-01

    Full Text Available The pupose of the research is to define the peculiarities of motor abilities development in children of middle-school age. Research methods: theoretical analysis and collation of scientific and methodological literature; pedagogical testing; methods of mathematical statistics. To determine the effectiveness of realization of the developmental task of the physical education process at the beginning of the school year (in October 2014 and in March 2015, we tested the level of development of physical qualities in the 7th- and 8th-graders, 25 and 25 graders respectively, 13 of which in each class were boys and 12 — girls. Research results. The analysis of the materials shows that during the school year, the boys of the 7th grade showed reliably increased performance in standing long jumps (speed and strength qualities — 1.97%, raising the body from the lying position (strength — 26.46%, bent suspension (strength — 13.45%. The indicators have insignificantly (unreliably increased in the shuttle run 3×10 m (agility — 6.09%, and in body bending from the sitting position (flexibility — 6.25%. The girls showed reliably increased performance in the level of readiness: flexibility — 12%, strength — 12.09%, speed-strength qualities — 5.27%, agility — 7.77%. The analysis of the materials shows that during the school year the 8th-graders (boys reliably increased their physical readiness in speed-strength qualities — 0.8%, strength — 15.7%. The indicators of agility increased unreliably — 2.7%, as well as those of flexibility — 8%. The 8th‑graders (girls reliably improved their indicators in standing long jumps — 2.1%, in bent suspension — 18.8%, raising the body from the lying position in 30 seconds — 17.4%, body bending from the sitting position — 12 5%. The indicators agility improved unreliably — 3.4%. Conclusions. The data obtained are important in solving the pedagogical problems of schoolers’ physical education

  14. 7th Annual Science and Engineering Technology Conference/DoD Technology Exposition Volume 1

    Science.gov (United States)

    2006-04-20

    Disruptive Technologies • Army Approach to Disruptive Technologies and Transition Mr. Dennis Schmidt, Director, Science & Technology Integration, Office of...the Assistant Secretary of the Army for Research and Technology • Navy Approach to Disruptive Technologies and Transition Mr. Lewis DeSandre, Program...Manager, ONR 351 • Air Force Approach to Disruptive Technologies and Transition Colonel Mark Stephen, Associate Deputy Assistant Secretary (Science

  15. Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells.

    Science.gov (United States)

    Abimannan, Thiruvaimozhi; Peroumal, Doureradjou; Parida, Jyoti R; Barik, Prakash K; Padhan, Prasanta; Devadas, Satish

    2016-10-01

    Reactive oxygen species (ROS) signaling is critical in T helper (Th) cell differentiation; however its role in differentiated Th cell functions is unclear. In this study, we investigated the role of oxidative stress on the effector functions of in vitro differentiated mouse Th17 and Th1 cells or CD4 + T cells from patients with Rheumatoid Arthritis using pro-oxidants plumbagin (PB) and hydrogen peroxide. We found that in mouse Th cells, non-toxic concentration of pro-oxidants inhibited reactivation induced expression of IL-17A in Th17 and IFN-γ in Th1 cells by reducing the expression of their respective TFs, RORγt and T-bet. Interestingly, in both the subsets, PB increased the expression of IL-4 by enhancing reactivation induced ERK1/2 phosphorylation. We further investigated the cytokine modulatory effect of PB on CD4 + T cells isolated from PBMCs of patients with Rheumatoid Arthritis, a well-known Th17 and or Th1 mediated disease. In human CD4 + T cells from Rheumatoid Arthritis patients, PB reduced the frequencies of IL-17A + (Th17), IFN - γ + (Th1) and IL-17A + /IFN - γ + (Th17/1) cells and also inhibited the production of pro-inflammatory cytokines TNF-α and IL-6. N-Acetyl Cysteine (NAC) an antioxidant completely reversed PB mediated cytokine modulatory effects in both mouse and human cells indicating a direct role for ROS. Together our data suggest that oxidative microenvironment can alter cytokine response of terminally differentiated cells and thus altering intracellular ROS could be a potential way to target Th17 and Th1 cells in autoimmune disorders. Copyright © 2016. Published by Elsevier Inc.

  16. Intratumoral Th2 predisposition combines with an increased Th1 functional phenotype in clinical response to intravesical BCG in bladder cancer.

    Science.gov (United States)

    Pichler, Renate; Gruenbacher, Georg; Culig, Zoran; Brunner, Andrea; Fuchs, Dietmar; Fritz, Josef; Gander, Hubert; Rahm, Andrea; Thurnher, Martin

    2017-04-01

    Th1-type immunity is considered to be required for efficient response to BCG in bladder cancer, although Th2 predisposition of BCG responders has recently been reported. The aim was to evaluate the relationship of Th1 and Th2 components in 23 patients undergoing BCG treatment. Peripheral blood, serum and urine samples were prospectively collected at baseline, during and after BCG. Th1 (neopterin, tryptophan, kynurenine, kynurenine-to-tryptophan ratio (KTR), IL-12, IFN-γ, soluble TNF-R75 and IL-2Rα) and Th2 (IL-4, IL-10) biomarkers as well as CD4 expression in T helper (Th), effector and regulatory T cells were determined. Local immune cell subsets were measured on formalin-fixed, paraffin-embedded cancer tissue by immunohistochemistry to examine expression of transcription factors that control Th1 (T-bet) and Th2-type (GATA3) immunity. We confirmed a Th2 predisposition with a mean GATA3/T-bet ratio of 5.51. BCG responders showed significantly higher levels of urinary (p = 0.003) and serum neopterin (p = 0.012), kynurenine (p = 0.015), KTR (p = 0.005), IFN-γ (p = 0.005) and IL-12 (p = 0.003) during therapy, whereas levels of IL-10 decreased significantly (p Th1-type immune responses and thus contribute to the BCG success.

  17. Extraction of MOS VLSI (Very-Large-Scale-Integrated) Circuit Models Including Critical Interconnect Parasitics.

    Science.gov (United States)

    1987-09-01

    level descrip- tion without human intervention. Although design rules and the layout function may not be checked, performance verification is still a...digital syvstems.- Proc. I1E1., vol. 69. no. 10. pp. 1200-1211. October 198 1. [2] A. Gupta, AT A circuit extractor." Proc. 20th Design Automiation

  18. Inquiry on nuclear fusion for peaceful uses by the 12th Committee of Industry of the Italian Parliament

    International Nuclear Information System (INIS)

    Bertolini, E.

    1987-01-01

    The paper is a statement by the author to the 12th Committee of Industry of the Italian Parliament concerning the Inquiry on nuclear fusion for peaceful uses. The basis concepts of thermonuclear fusion are outlined. A description is given of the European Programme, and the role of the JET Project within that Programme. The role of the JET Project in the field of fusion research is described, in detail. Preliminary answers to the Committee's questions on fusion posed previously are also reported. (U.K.)

  19. Encadrement des produits et des procédés : réglementation et normalisation du commerce international

    Directory of Open Access Journals (Sweden)

    Morin Odile

    2003-07-01

    Full Text Available Produits et procédés sont encadrés à la fois par des réglementations et, à un autre niveau, par des normes du commerce international. Cette présentation traite des textes réglementaires au niveau communautaire et national. On rappellera que l’entrée en vigueur d’un règlement européen est suivie d’une transposition dans le droit de chaque pays membre et que la réglementation nationale s’applique en l’absence de dispositions communautaires. En matière de commerce international, seront évoquées les actions de normalisation du Conseil Oléicole International (COI pour les huiles d’olive et de grignons d’olive et celles du Codex Alimentarius pour les huiles et graisses comestibles. L’ensemble des dispositions réglementaires constitue un cadre englobant les productions de l’amont vers l’aval, à la fois sur un plan vertical (oléagineux, huiles et corps gras, huiles d’olive, margarines, procédés de raffinage et transversalement (composés organiques volatils, OGM, solvants d’extraction, additifs, contaminants…. Le cas de l’huile d’olive est particulier en ce qu’il bénéficie d’un encadrement au niveau international (normes commerciales COI et Codex Alimentarius, européen et national (réglementation. Le Codex Alimentarius, quant à lui, établit des normes à caractère vertical (huiles végétales, graisses animales, huiles d’olive, matières grasses tartinables… et horizontal (additifs, résidus de pesticides…. L’essentiel de cet encadrement est résumé dans les tableaux qui illustrent cette contribution.

  20. Transformation of Waves Across the Surf Zone.

    Science.gov (United States)

    1981-03-01

    Kuo is more realis- tic but still results in a sharp cut-off of the distribution at the breaking heights. 5. Goda Distribution Goda (1975) derived a...J.I., "Probabilities of Breaking Wave Characteris- tics ," Proc. 12th Coastal Engineering Conf., pp. 399- 412, 1970. Chakrabarty, S.K. and R.P. Cooley...Spring, MD 20910 21. Director 2 Instituto Oceanografico de la Armada Guayaquil, Ecuador 22. Director de Educacion de la Armada Comandancia General de

  1. Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.

    Science.gov (United States)

    Li, Jing; Dong, Xiaojing; Zhao, Lei; Wang, Xiao; Wang, Yan; Yang, Xi; Wang, Hong; Zhao, Weiming

    2016-07-01

    Natural killer (NK) cell is an important component in innate immunity, playing a critical role in bridging innate and adaptive immunity by modulating the function of other immune cells including T cells. In this study, we focused on the role of NK cells in regulating Th1/Treg and Th17/Treg balance during chlamydial lung infection. We found that NK cell-depleted mice showed decreased Th1 and Th17 cells, which was correlated with reduced interferon-γ, interleukin (IL)-12, IL-17 and IL-22 production as well as T-bet and receptor-related orphan receptor gamma t expression compared with mice treated with the isotype control antibody. In contrast, NK cell depletion significantly increased Treg in cell number and related transcription factor (Foxp3) expression. The opposite trends of changes of Th1/Th17 and Treg led to significant reduction in the Th1/Treg and Th17/Treg ratios. The data implicate that NK cells play an important role in host defence against chlamydial lung infection, mainly through maintaining Th1/Treg and Th17/Treg balance. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  2. The 12th quality control survey for radioisotope in vitro tests in Japan, 1990

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    The results of the 12th quality control nationwide survey is presented. Of 670 selected facilities, 405 (60.4%) participated in this survey. Myoglobin and trypsin were added as new items to be examined. The other conventional items were as follows: alpha-fetoprotein (AFP), aldosterone, {beta}{sub 2}-microglobulin, carbohydrate angigen 15-3, C-peptide, digoxin, elastase 1, free triiodothyronine, growth hormone, immunoglobulin E, prostatic acid phosphatase, pancreatic secretory trypsin inhibitor, progesterone, prolactin, thyroglobulin, triiodothyronine (T{sub 3}), T{sub 3} uptake, tissue polypeptide antigen, thyroid stimulating hormone, and testosterone. There was a great coefficient of variation (CV) between kits in AFP, aldosterone, progesterone, and prolactin. These results were analogous to those in the previous surveys. For T{sub 3}, there was a great difference between CV by radioimmunoassay and by non-isotopic method. Both myoglobin and trypsin had a great difference between kits. (N.K.).

  3. Intestinal Irradiation and Fibrosis in a Th1-Deficient Environment

    International Nuclear Information System (INIS)

    Linard, Christine; Billiard, Fabienne; Benderitter, Marc

    2012-01-01

    Purpose: Changes in the Th1/Th2 immune balance may play a role in increasing the incidence of radiation-induced toxicity. This study evaluates the consequences of Th1 deficiency on intestinal response (fibrosis and T cell trafficking) to abdominal irradiation and examines in mucosa and mesenteric lymph nodes (MLN) the differential involvement of the two Th1 pathways, T-bet/STAT1 and IL-12/STAT4, in controlling this balance in mice. Methods and Materials: Using T-bet-deficient mice (T-bet −/− ), we evaluated the mRNA and protein expression of the Th1 pathways (IFN-γ, T-bet/STAT1, and IL-12/STAT4) and the CD4 + and CD8 + populations in ileal mucosa and MLN during the first 3 months after 10 Gy abdominal irradiation. Results: The T-bet-deficient mice showed an increased fibrotic response to radiation, characterized by higher TGF-β1, col3a1 expression, and collagen deposition in mucosa compared with wild-type mice. This response was associated with drastically lower expression of IFN-γ, the hallmark Th1 cytokine. Analysis of the Th1 expression pathways, T-bet/STAT1 and IL-12/STAT4, showed their equal involvement in the failure of Th1 polarization. A minimal IFN-γ level depended on the IL-23-p19/STAT4 level. In addition, the radiation-induced deficiency in the priming of Th1 by IFN-γ was related to the defective homing capacity of CD8 + cells in the mucosa. Conclusion: Irradiation induces Th2 polarization, and the Th2 immune response may play a role in potentiating irradiation-induced intestinal collagen deposition.

  4. Annual Science and Engineering Technology Conference/DOD Technology Exposition (7th). Volume 2. Wednesday - Thursday

    Science.gov (United States)

    2006-04-20

    Disruptive Technologies • Army Approach to Disruptive Technologies and Transition Mr. Dennis Schmidt, Director, Science & Technology Integration, Office of...the Assistant Secretary of the Army for Research and Technology • Navy Approach to Disruptive Technologies and Transition Mr. Lewis DeSandre, Program...Manager, ONR 351 • Air Force Approach to Disruptive Technologies and Transition Colonel Mark Stephen, Associate Deputy Assistant Secretary (Science

  5. Annual Disruptive Technologies Conference (8th) Held in Washington, DC on November 8-9, 2011

    Science.gov (United States)

    2011-11-09

    I also appreciate speaking early in the lineup of presentations since it minimizes the chance that I will contradict something you have already...Architectures Enterprise Working Meeting (S&T, CAPE, Policy, COCOM) OV-1 Architecture Definition Industry Day Enabling Technology Identification ...year turnaround time  Video: www.youtube.com/usnavyresearch  Requests submitted online www.onr.navy.mil/techsolutions • Ship Identification

  6. Proceedings of the 2004 NASA/ONR Circulation Control Workshop, Part 2

    Science.gov (United States)

    Jones, Gregory S. (Editor); Joslin, Ronald D. (Editor)

    2005-01-01

    This conference proceeding is comprised of papers that were presented at the NASA/ONR Circulation Control Workshop held 16-17 March 2004 at the Radisson-Hampton in Hampton, VA. Over two full days, 30 papers and 4 posters were presented with 110 scientists and engineers in attendance, representing 3 countries. As technological advances influence the efficiency and effectiveness of aerodynamic and hydrodynamic applications, designs, and operations, this workshop was intended to address the technologies, systems, challenges and successes specific to Coanda driven circulation control in aerodynamics and hydrodynamics. A major goal of this workshop was to determine the state-of-the-art in circulation control and to assess the future directions and applications for circulation control. The 2004 workshop addressed applications, experiments, computations, and theories related to circulation control, emphasizing fundamental physics, systems analysis, and applied research. The workshop consisted of single session oral presentations, posters, and written papers that are documented in this unclassified conference proceeding. The format of this written proceeding follows the agenda of the workshop. Each paper is followed with the presentation given at the workshop. the editors compiled brief summaries for each effort that is at the end of this proceeding. These summaries include the paper, oral presentation, and questions or comments that occurred during the workshop. The 2004 Circulation Control Workshop focused on applications including Naval vehicles (Surface and Underwater vehicles), Fixed Wing Aviation (general aviation, commercial, cargo, and business aircraft); V/STOL platforms (helicopters, military aircraft, tilt rotors); propulsion systems (propellers, jet engines, gas turbines), and ground vehicles (automotive, trucks, and other); wind turbines, and other nontraditional applications (e.g., vacuum cleaner, ceiling fan). As part of the CFD focus area of the 2004 CC

  7. tant sorghum grain as energy source in fattening diets for beef steers

    African Journals Online (AJOL)

    FORD, J.E., 1977. Availability of methionine and lysine in sorghum grain in relation to the tannin content. Proc. Nutr. Soc. 36, 124A. HALE, W.H. & PROUTY, F.L., 1980.Current status of grain process- ing: Efficiency of processing systems. Proc. 8th Annual Texas Beef. Conj., Amarillo, Texas. HALE, W.H., TAYLOR, B., SABA, ...

  8. Alcohol mixed with energy drink use among u.s. 12th-grade students: prevalence, correlates, and associations with unsafe driving.

    Science.gov (United States)

    Martz, Meghan E; Patrick, Megan E; Schulenberg, John E

    2015-05-01

    The consumption of alcohol mixed with energy drinks (AmED) is a risky drinking behavior, most commonly studied using college samples. We know little about rates of AmED use and its associations with other risk behaviors, including unsafe driving, among high school students. This study examined the prevalence and correlates of AmED use among high school seniors in the United States. Nationally representative analytic samples included 6,498 12th-grade students who completed Monitoring the Future surveys in 2012 and 2013. Focal measures included AmED use, sociodemographic characteristics, academic and social factors, other substance use, and unsafe driving (i.e., tickets/warnings and accidents) after alcohol consumption. Approximately one in four students (24.8%) reported AmED use during the past 12 months. Rates of AmED use were highest among males and white students. Using multivariable logistic regression models controlling for sociodemographic characteristics, results indicate that students who cut class, spent more evenings out for fun and recreation, and reported binge drinking, marijuana use, and illicit drug use had a greater likelihood of AmED use. AmED use was also associated with greater odds of alcohol-related unsafe driving, even after controlling for sociodemographic, academic, and social factors and other substance use. AmED use among 12th-grade students is common and associated with certain sociodemographic, academic, social, and substance use factors. AmED use is also related to alcohol-related unsafe driving, which is a serious public health concern. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  9. FY 1998 Report on development of technologies for commercialization of photovoltaic power systems. International co-operative project (IEA implementing agreement for a co-operative programme on photovoltaic power systems, 11th and 12th executive committee meetings); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu kokusai kyoryoku jigyo. IEA taiyoko hatsuden system kenkyu kyoryoku program jisshi kyotei dai 12 kai dai 11 kai shikko iinkai

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Described herein are outline of the International Energy Agency/Co-operative programme on Photovoltaic Power Systems (IEA/PVPS), and minutes of the 11th and 12th executive committee meetings. Japan signed the IEA Implementing Agreement for a co-operative programme on Photovoltaic Power Systems in April 1993, and has been participating in the programme for research and development, demonstration, analysis, information exchange and introduction promotion, among others. Presented to the 11th executive committee meeting are progresses in each task, review of the PVPS programme by an independent reviewer, strategy for the next term of the PVPS agreement, and marketing of PV in the IEA member countries. The meeting also has confirmed the action plans and partial responsibilities. In the 12th executive committee meeting, the progresses of the tasks, e.g., objects, activities and problems, are reported, and reviewed by the participants. Discussed in the task 1, information exchange, are new communication methods, publication frequency and contents of Internal Survey Report, and opening of the internet home page, among others. (NEDO)

  10. Nineth Rib Syndrome after 10(th) Rib Resection.

    Science.gov (United States)

    Yu, Hyun Jeong; Jeong, Yu Sub; Lee, Dong Hoon; Yim, Kyoung Hoon

    2016-07-01

    The 12(th) rib syndrome is a disease that causes pain between the upper abdomen and the lower chest. It is assumed that the impinging on the nerves between the ribs causes pain in the lower chest, upper abdomen, and flank. A 74-year-old female patient visited a pain clinic complaining of pain in her back, and left chest wall at a 7 on the 0-10 Numeric Rating scale (NRS). She had a lateral fixation at T12-L2, 6 years earlier. After the operation, she had multiple osteoporotic compression fractures. When the spine was bent, the patient complained about a sharp pain in the left mid-axillary line and radiating pain toward the abdomen. On physical examination, the 10(th) rib was not felt, and an image of the rib-cage confirmed that the left 10(th) rib was severed. When applying pressure from the legs to the 9(th) rib of the patient, pain was reproduced. Therefore, the patient was diagnosed with 9(th) rib syndrome, and ultrasound-guided 9(th) and 10(th) intercostal nerve blocks were performed around the tips of the severed 10(th) rib. In addition, local anesthetics with triamcinolone were administered into the muscles beneath the 9(th) rib at the point of the greatest tenderness. The patient's pain was reduced to NRS 2 point. In this case, it is suspected that the patient had a partial resection of the left 10(th) rib in the past, and subsequent compression fractures at T8 and T9 led to the deformation of the rib cage, causing the tip of the remaining 10(th) rib to impinge on the 9(th) intercostal nerves, causing pain.

  11. Intestinal Irradiation and Fibrosis in a Th1-Deficient Environment

    Energy Technology Data Exchange (ETDEWEB)

    Linard, Christine, E-mail: christine.linard@irsn.fr [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Billiard, Fabienne; Benderitter, Marc [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)

    2012-09-01

    Purpose: Changes in the Th1/Th2 immune balance may play a role in increasing the incidence of radiation-induced toxicity. This study evaluates the consequences of Th1 deficiency on intestinal response (fibrosis and T cell trafficking) to abdominal irradiation and examines in mucosa and mesenteric lymph nodes (MLN) the differential involvement of the two Th1 pathways, T-bet/STAT1 and IL-12/STAT4, in controlling this balance in mice. Methods and Materials: Using T-bet-deficient mice (T-bet{sup -/-}), we evaluated the mRNA and protein expression of the Th1 pathways (IFN-{gamma}, T-bet/STAT1, and IL-12/STAT4) and the CD4{sup +} and CD8{sup +} populations in ileal mucosa and MLN during the first 3 months after 10 Gy abdominal irradiation. Results: The T-bet-deficient mice showed an increased fibrotic response to radiation, characterized by higher TGF-{beta}1, col3a1 expression, and collagen deposition in mucosa compared with wild-type mice. This response was associated with drastically lower expression of IFN-{gamma}, the hallmark Th1 cytokine. Analysis of the Th1 expression pathways, T-bet/STAT1 and IL-12/STAT4, showed their equal involvement in the failure of Th1 polarization. A minimal IFN-{gamma} level depended on the IL-23-p19/STAT4 level. In addition, the radiation-induced deficiency in the priming of Th1 by IFN-{gamma} was related to the defective homing capacity of CD8{sup +} cells in the mucosa. Conclusion: Irradiation induces Th2 polarization, and the Th2 immune response may play a role in potentiating irradiation-induced intestinal collagen deposition.

  12. Simulació d'un procés industrial de cristallització de clorur de sodi (NaCl i aplicacions

    Directory of Open Access Journals (Sweden)

    Josefina Renedo Omaechevarría

    2014-12-01

    Full Text Available La cristal·lització a partir de dissolucions és important industrialment  donada la gran varietat de substàncies que es comercialitzen  cristal·litzades. Per millorar el procés  d’ensenyament-aprenentatge d’aquesta “Operació Bàsica”, en aquest treball, realitzat com a Treball de Fi de Carrera de la titulació  d’ Enginyeria Química, s’ha  desenvolupat un programa de simulació d’una cristal·lització industrial de NaCl.  L’objectiu ha sigut manejar  eines de càlcul  per simular  i optimitzar una cristal·lització, la qual cosa permet conèixer més profundament el procés de la cristal·lització i la utilització de les eines de càlcul, és a dir, utilitzar simultàniament els coneixements adquirits en les assignatures de Operacions amb Sòlid  i la de Simulació i Optimització de Processos. L’objectiu últim de l’ús d’aquest programa de simulació és que els estudiants de l’assignatura optativa Operacions  amb Sòlids del Grau en Enginyeria Química puguin fer servir aquest recurs a l’aula. Amb el programa utilitzat, en llenguatge Fortran, obtenim, d’una manera ràpida i eficaç, la velocitat de creixement dels cristalls G i la velocitat de nucleació B. Un cop calculats els valors de G i B, es pot programar una cristal·lització per obtenir  la distribució de tamany de cristall (DTC desitjat. Per últim s´han determinat els valors dels paràmetres cinètiques de B0.

  13. PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

    Directory of Open Access Journals (Sweden)

    Yutaka Kurebayashi

    2012-04-01

    Full Text Available The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis by deletion of p85α or PI3K/mTORC1 inhibitors as well as T cell-specific deletion of raptor, an essential component of mTORC1, impairs Th17 differentiation in vitro and in vivo in a S6K1/2-dependent fashion. Inhibition of PI3K-Akt-mTORC1-S6K1 axis impairs the downregulation of Gfi1, a negative regulator of Th17 differentiation. Furthermore, we demonstrate that S6K2, a nuclear counterpart of S6K1, is induced by the PI3K-Akt-mTORC1 axis, binds RORγ, and carries RORγ to the nucleus. These results point toward a pivotal role of PI3K-Akt-mTORC1-S6K1/2 axis in Th17 differentiation.

  14. Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis.

    Science.gov (United States)

    Lin, Jinpiao; Xiao, Lianbo; Ouyang, Guilin; Shen, Yu; Huo, Rongfen; Zhou, Zhou; Sun, Yue; Zhu, Xianjin; Zhang, Jie; Shen, Baihua; Li, Ningli

    2012-12-01

    Total glucoside of paeony (TGP), an active compound extracted from paeony root, has been used in therapy for rheumatoid arthritis (RA). Th1 and Th17 cells are now believed to play crucial roles in the lesions of RA. However, the molecular mechanism of TGP in inhibition of Th1 and Th17 cells remains unclear. In this study, we found that TGP treatment significantly decreased percentage and number of Th1 and Th17 cells in collagen induced arthritis (CIA) mice. Consistently, treatment with TGP decreased expression of T-bet and RORγt as well as phosphorylation of STAT1 and STAT3. In particular, TGP treatment inhibited dendritic cells (DCs) maturation and reduced production of IL-12 and IL-6. Moreover, TGP-treatment RA patients showed shank population of matured DCs and IFN-γ-, IL-17-producing cells. Taken together, our results demonstrated that TGP inhibited maturation and activation of DCs, which led to impaired Th1 and Th17 differentiation in vivo. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. A convenient approach to 10-12 g/ g ICP-MS limits for Th and U in aurubis electrolytic NA-ESN brand copper

    Science.gov (United States)

    Leonard, Douglas S.

    2014-06-01

    Inductively-coupled-plasma mass spectroscopy is a powerful technique for measuring trace levels of radioactive contaminants, specifically Th and U, in materials for use in construction of low-background rare-event detectors such as double beta decay and dark matter detectors. I describe here a technique for measuring Th and U contamination in copper by using direct acid digestion and dilution without further chemical processing, achieving results comparable to those achieved in previous work [1, 2] which utilized more complex chemical pre-concentration techniques. A convenient research-oriented analysis environment is described as well. Results are presented for measurements of three samples from the production line of electrolytically-purified, LME (London Metal Exchange) grade A, NA-ESN Aurubis copper. Purified samples showed levels consistent with zero contamination for both elements, while weak, but inconclusive, indications of contamination were present for the unpurified anode copper. The best limits achieved are near 1•10-12 g/ g (95% CL) for both Th and U measured for copper from the cathode of the purification process.

  16. Effect of Intravenous immunoglobulin on Th1 and Th2 lymphocytes and improvement of pregnancy outcome in recurrent pregnancy loss (RPL).

    Science.gov (United States)

    Ahmadi, Majid; Abdolmohammadi-Vahid, Samaneh; Ghaebi, Mahnaz; Aghebati-Maleki, Leili; Afkham, Amir; Danaii, Shahla; Abdollahi-Fard, Sedigheh; Heidari, Lida; Jadidi-Niaragh, Farhad; Younesi, Vahid; Nouri, Mohammad; Yousefi, Mehdi

    2017-08-01

    Women with elevated natural killer (NK) cell frequency and function during pregnancy, suffer from recurrent pregnancy loss (RPL). In the present study, the possible effect of intravenous immunoglobulin (IVIG) administration on Th1 and Th2 cell frequency, cytokine secretion, and expression of transcription factors is compared between RPL patients and control group. Totally, 44 women with a history of RPL (32 women as treated group and 12 as control group) were enrolled in the study. The frequency of Th1 and Th2 lymphocytes, the expression of transcription factors related to these cells and the serum levels of associated cytokines were assessed by flowcytometry, real-time PCR and ELISA, respectively. All, assessments were performed both before and after treatment with IVIG. A significant reduction in Th1 lymphocyte frequency, transcription factor expression and cytokine levels were observed in IVIG-treated group, while all the above parameters indicated a significant increase for Th2 lymphocytes. Th1/Th2 ratio decreased significantly (p value<0.0001) at the end of treatment and 28 out of 32 (87.5%) women in IVIG-treated group had live birth in comparison with 5 out of 12 (41.6%) in untreated group. IVIG administration proves to be an efficient therapeutic strategy which is able to enhance the success rate of pregnancy through a shift in Th2 responses. Furthermore, IVIG presents efficacy for the treatment of reproduction failures especially in subjects with immune cell abnormalities and increased NK cell level and function. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  17. Fulltext PDF

    Indian Academy of Sciences (India)

    The relativistic wave equation of the electron ranks anlO- ng the highest achievements of 20th century science. Dirac's two papers on the subject published in 1928 are the following:- P.A.M. Dirac, Proc. Roy. Soc. Al17, 610, 1928. P.A.M. Dirac, Proc. Roy. Soc. Al18, 351, 1928. Dirac himself is supposed to have reuw.rked that ...

  18. Analysis of the influence of the heat transfer phenomena on the late phase of the ThAI Iod-12 test

    Science.gov (United States)

    Gonfiotti, B.; Paci, S.

    2014-11-01

    Iodine is one of the major contributors to the source term during a severe accident in a Nuclear Power Plant for its volatility and high radiological consequences. Therefore, large efforts have been made to describe the Iodine behaviour during an accident, especially in the containment system. Due to the lack of experimental data, in the last years many attempts were carried out to fill the gaps on the knowledge of Iodine behaviour. In this framework, two tests (ThAI Iod-11 and Iod-12) were carried out inside a multi-compartment steel vessel. A quite complex transient characterizes these two tests; therefore they are also suitable for thermal- hydraulic benchmarks. The two tests were originally released for a benchmark exercise during the SARNET2 EU Project. At the end of this benchmark a report covering the main findings was issued, stating that the common codes employed in SA studies were able to simulate the tests but with large discrepancies. The present work is then related to the application of the new versions of ASTEC and MELCOR codes with the aim of carry out a new code-to-code comparison vs. ThAI Iod-12 experimental data, focusing on the influence of the heat exchanges with the outer environment, which seems to be one of the most challenging issues to cope with.

  19. PREFACE: 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity and 9th International Conference on Functional Materials and Nanotechnologies (RCBJSF-2014-FM&NT)

    Science.gov (United States)

    Sternberg, Andris; Grinberga, Liga; Sarakovskis, Anatolijs; Rutkis, Martins

    2015-03-01

    The joint International Symposium RCBJSF-2014-FM&NT successfully has united two international events - 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity (RCBJSF-12) and 9th International Conference Functional Materials and Nanotechnologies (FM&NT-2014). The RCBJSF symposium is a continuation of series of meetings on ferroelectricity, the first of which took place in Novosibirsk (USSR) in 1976. FM&NT conferences started in 2006 and have been organized by Institute of Solid State Physics, University of Latvia in Riga. In 2012 the International program committee decided to transform this conference into a traveling Baltic State conference and the FM&NT-2013 was organized by the Institute of Physics, University of Tartu, Estonia. In 2014 the joint international symposium RCBJSF-2014-FM&NT was organized by the Institute of Solid State Physics, University of Latvia and was part of Riga - 2014, the European Capital of Culture event. The purpose of the joint Symposium was to bring together scientists, students and high-level experts in solid state physics, materials science, engineering and related disciplines. The number of the registered participants from 26 countries was over 350. During the Symposium 128 high quality scientific talks (5 plenary, 42 invited, 81 oral) and over 215 posters were presented. All presentations were divided into 4 parallel sessions according to 4 main topics of the Symposium: Ferroelectricity, including ferroelectrics and multiferroics, pyroelectrics, piezoelectrics and actuators, integrated ferroelectrics, relaxors, phase transitions and critical phenomena. Multifunctional Materials, including theory, multiscale and multiphenomenal material modeling and simulation, advanced inorganic, organic and hybrid materials. Nanotechnologies, including progressive methods, technologies and design for production, investigation of nano- particles, composites, structures, thin films and coatings. Energy, including perspective materials and

  20. Proceedings of the Annual Military Librarians’ Workshop (29th) Held in Colorado Springs, CO, on 9-11 October 1985

    Science.gov (United States)

    1985-10-11

    system that has a digital imaging and printing system wil’l revolutionize the way we do things and will be a model that any organization of any size among...aeronautical significance, are bibliographic treasures because they are superb examples of fine book binding, printing, illustration, and typography . Onre

  1. Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses.

    Science.gov (United States)

    Ye, Zi; Deng, Bolin; Wang, Chaokui; Zhang, Dike; Kijlstra, Aize; Yang, Peizeng

    2016-02-04

    Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In this study, we investigated whether BTLA activation could be exploited to inhibit the development of abnormal immune responses in BD patients. BTLA expression in PBMCs and CD4(+) T cells was significantly decreased in active BD patients. Decreased BTLA level was associated with increased Th17 and Th1 responses. Activation of BTLA inhibited the abnormal Th17 and Th1 responses and IL-22 expression in both patients and controls. Addition of an agonistic anti-BTLA antibody remarkably inhibited DC-induced Th17 and Th1 cell responses, resulted in decreased production of the Th17 and Th1-related cytokines IL-1beta, IL-6, IL-23 and IL-12p70 and reduced CD40 expression in DCs. In conclusion, decreased BTLA expression in ocular BD may lead to inappropriate control of the Th17 and Th1 immune responses and DC functions. Therefore, BTLA may be involved in the development and recurrence of this disease. Agonistic agents of BTLA may represent a potential therapeutic approach for the treatment of BD and other inflammatory diseases mediated by abnormal Th17 and Th1 immune responses.

  2. The effect of antenatal steroids on fetal lung maturation between the 34th and 36th week of pregnancy.

    Science.gov (United States)

    Balci, Osman; Ozdemir, Suna; Mahmoud, Alaa S; Acar, Ali; Colakoglu, Mehmet C

    2010-01-01

    To evaluate the effect of antenatal treatment with a single dose of betamethasone between the 34th and the 36th week of pregnancy on the maturation of fetal lung. To study 100 pregnant women in their 34th-36th week of pregnancy who were diagnosed as susceptible to have preterm delivery. Fifty patients did not receive betamethasone (group 1). The other 50 patients were administered 12 mg betamethasone in a single dose (group 2). Patients who delivered at least 24 h after the administration of betamethasone were included in this study. After delivery, the Apgar score and the development of respiratory distress syndrome (RDS) in the neonates were compared. Group 2 babies had better Apgar scores when compared to group 1, and the difference was statistically significant. Sixteen (32%) neonates of group 1 and 7 (14%) neonates of group 2 required resuscitation, and the difference was statistically significant (p = 0.032; OR = 0.34, 95% CI 0.12-0.93). RDS was detected in 8 newborns of group 1 and 2 of group 2. The difference was statistically significant (p = 0.046; OR = 0.21, 95% CI 0.04-1.08). The administration of a single dose of betamethasone to pregnant women in their 34th-36th week of pregnancy who are likely to have preterm delivery reduces RDS development. There is a need for larger studies to confirm these results. Copyright 2010 S. Karger AG, Basel.

  3. Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

    Directory of Open Access Journals (Sweden)

    Stefano M Santini

    Full Text Available IFN-α exerts multiple effects leading to immune protection against pathogens and cancer as well to autoimmune reactions by acting on monocytes and dendritic cells. We analyzed the versatility of human monocytes conditioned by IFN-α towards dendritic cell differentiation (IFN-DC in shaping the autologous T-helper response. Priming of naïve CD4 T cells with autologous IFN-DC in the presence of either SEA or anti-CD3, resulted, in addition to a prominent expansion of CXCR3+ IFN-γ-producing CD4 Th1 cells, in the emergence of two distinct subsets of IL-17-producing CD4 T cells: i a predominant Th17 population selectively producing IL-17 and expressing CCR6; ii a minor Th1/Th17 population, producing both IL-17 and IFN-γ. After phagocytosis of apoptotic cells, IFN-DC induced Th17 cell expansion and IL-17 release. Notably, the use of neutralizing antibodies revealed that IL-23 was an essential cytokine in mediating Th17 cell development by IFN-DC. The demonstration of the IFN-DC-induced expansion of both Th1 and Th17 cell populations reveals the intrinsic plasticity of these DC in orienting the immune response and provides a mechanistic link between IFN-α and the onset of autoimmune phenomena, which have been correlated with both IL-17 production and exposure to IFN-α.

  4. Crystal structures of Th(OH)PO4, U(OH)PO4 and Th2O(PO4)2. Condensation mechanism of M(IV)(OH)PO4 (M= Th, U) into M2O(PO4)2

    International Nuclear Information System (INIS)

    Dacheux, N.; Clavier, N.; Wallez, G.; Quarton, M.

    2007-01-01

    Three new crystal structures, isotypic with β-Zr 2 O(PO 4 ) 2 , have been resolved by the Rietveld method. All crystallize with an orthorhombic cell (S.G.: Cmca) with a = 7.1393(2) Angstroms, b = 9.2641(2) Angstroms, c 12.5262(4) Angstroms, V = 828.46(4) (Angstroms) 3 and Z = 8 for Th(OH)PO 4 ; a = 7.0100(2) Angstroms, b = 9.1200(2) Angstroms, c = 12.3665(3) Angstroms, V 790.60(4) (Angstroms) 3 and Z = 8 for U(OH)PO 4 ; a 7.1691(3) Angstroms, b 9.2388(4) Angstroms, c = 12.8204(7) Angstroms, V 849.15(7) (Angstroms) 3 and Z = 4 for Th 2 O(PO 4 ) 2 . By heating, the M(OH)PO 4 (M Th, U) compounds condense topotactically into M 2 O(PO 4 ) 2 , with a change of the environment of the tetravalent cation that lowers from 8 to 7 oxygen atoms. The lower stability of Th 2 O(PO 4 ) 2 compared to that of U 2 O(PO 4 ) 2 seems to result from this unusual environment for tetravalent thorium. (authors)

  5. Effect of low dose radiation on Th1 and Th2 of thymocytes and splenocytes in mice

    International Nuclear Information System (INIS)

    Bai Ou; Liu Shuzheng; Mu Ying

    1998-01-01

    Objective: To elucidate the possible mechanism of activation of helper T cells after low dose radiation (LDR) exposure, the influence of whole-body irradiation (WBI) with 75 mGy X-rays on Th1 and Th2 was studied. Methods: Mice were irradiated at a dose rate of 12.5 mGy/min, and IFN-γ and IL-6 mRNA levels of the myocytes and splenocytes were analyzed by dot blot and Northern blot hybridization. Results: It was found that IFN-γ and IL-6 mRNA significantly increased after WBI with 75 mGy X-rays. Conclusion: The gene induction of cytokine profile after LDR indicates that activation of both Th1 and Th2 subtypes may be involved in the stimulation of immune functions by LDR

  6. Octupole deformation in 226Th

    International Nuclear Information System (INIS)

    Liang, C.F.; Paris, P.; Sheline, R.K.

    1999-01-01

    Sources of 230 U - resulting from the β - decay of 230 Pa produced in the reaction 232 Th(p,3n) with 34 MeV protons - were purified and used to determine the half life of the 230.4 keV 1 - state in 226 Th. Using the Doppler shift method, following α decay of 230 U, a value T 1/2 = 3.5 ± 1.2 ps was determined. The half life of the 226.4 keV 4 + state was also measured as T 1/2 = 145 ± 20 ps. The absolute probabilities in Weisskopf units of the 230 keV and 158 keV γ transitions depopulating the 1 - state were determined as (2.50 ± 0.86) x 10 -3 and (4.54 ± 1.55) x 10 -3 respectively. Experimental values of the intrinsic dipole moment, D 0 , and of D 0 /Q 0 , were determined as 0.27 ± 0.05 e.fm and (3.5 ± 1.0) x 10 -4 fm -1 . These data have been compared with theories and experiment. (authors)

  7. Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways.

    Directory of Open Access Journals (Sweden)

    Giorgio Fedele

    Full Text Available The complex pathology of B. pertussis infection is due to multiple virulence factors having disparate effects on different cell types. We focused our investigation on the ability of B. pertussis to modulate host immunity, in particular on the role played by adenylate cyclase toxin (CyaA, an important virulence factor of B. pertussis. As a tool, we used human monocyte derived dendritic cells (MDDC, an ex vivo model useful for the evaluation of the regulatory potential of DC on T cell immune responses. The work compared MDDC functions after encounter with wild-type B. pertussis (BpWT or a mutant lacking CyaA (BpCyaA-, or the BpCyaA- strain supplemented with either the fully functional CyaA or a derivative, CyaA*, lacking adenylate cyclase activity. As a first step, MDDC maturation, cytokine production, and modulation of T helper cell polarization were evaluated. As a second step, engagement of Toll-like receptors (TLR 2 and TLR4 by B. pertussis and the signaling events connected to this were analyzed. These approaches allowed us to demonstrate that CyaA expressed by B. pertussis strongly interferes with DC functions, by reducing the expression of phenotypic markers and immunomodulatory cytokines, and blocking IL-12p70 production. B. pertussis-treated MDDC promoted a mixed Th1/Th17 polarization, and the activity of CyaA altered the Th1/Th17 balance, enhancing Th17 and limiting Th1 expansion. We also demonstrated that Th1 effectors are induced by B. pertussis-MDDC in the absence of IL-12p70 through an ERK1/2 dependent mechanism, and that p38 MAPK is essential for MDDC-driven Th17 expansion. The data suggest that CyaA mediates an escape strategy for the bacterium, since it reduces Th1 immunity and increases Th17 responses thought to be responsible, when the response is exacerbated, for enhanced lung inflammation and injury.

  8. IAEA technical committee meeting: 12th meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Clark, R E.H. [International Atomic Energy Agency, Vienna (Austria)

    2000-12-01

    This report briefly describes the proceedings, conclusions and recommendations of the 12th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council held on May 8-9, 2000 at the IAEA Headquarters in Vienna Austria. The report includes the Executive Summary of the Subcommittee from this Meeting which was communicated to the IAEA Director General as well as the report on the activities of the IAEA Atomic and Molecular Data Unit for the period June 1999 - May 2000. (author)

  9. Security Tagged Architecture Co-Design (STACD)

    Science.gov (United States)

    2015-09-01

    the FPGA system. • CAD Infrastructure: Setup a standard-cell Application-Specific Integrated Circuit (ASIC) flow for the IBM 65nm process. Develop a...Warfield, "Xen and the Art of virtualization," in Proc. 19th ACM SOSP, 2003. [12] R. J. Creasy, "The origin of the VM/370 Time-sharing System," IBM ...M. Watson , J. Woodruff, P. G. Neumann, S. W. Moore, J. Anderson, D. Chisnall, N. Dave, B. Davis, K. Gudka, B. Laurie, S. J. Murdoch, R. Norton, M

  10. Progress in 11th Five Year and the geneal idea for 12th Five Year of uranium exploration and geological science and technology

    International Nuclear Information System (INIS)

    Zhang Jindai; Jian Xiaofei; Li Youliang; Du Jiannong; Guo Qinggen; Zhang Qiuying

    2011-01-01

    Since the 11th-Five Year, uranium exploration in China has retrieved obviously and some new resources have been identified. More detailed uranium exploration has been carried out in about 1 000 000 km 2 , exploration in large uranium resource bases, old orefields and focusing prospect areas has achieved important progress, several middle-large and extral-large deposits have been discovered, and one super-large deposit was submitted for the first time in China. In the science and technology of uranium exploration, the capability and platform of research has been reinforced, a number of key projects have been carried out such as national uranium potential evaluation, study of 'four types of uranium deposit', research for the enlargement of uranium resource bases, research of application foundation of uranium geology, research on exploratin techniques and method and technological standard. All these projects have obtained fruitful result and significantly raised the creative level in uranium science and technology. In the coming 12th Five Year, uranium exploration will follow the strategy of 'foundation research first with focus on resource base,systematical exploration and integral evaluation second' under the guideline of 'domestic foothold and oversea development' and set up large uranium resource bases, four major geological preosecting programs will be commence in the exploration for large uranium resource base, national uranium survey, regional evaluation of potential uranium resource and science and technology innovation of uranium geology, Ideas of 'Great uranium exploration system' should be set up to widely unite the localized prospecting teams and cooperate with the geologic research organization such as domestic and foreign university and college so as to make corespondent contribution to raise the supporting capability of uranium resources in China. (authors)

  11. Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development

    NARCIS (Netherlands)

    Smits, Hermelijn H.; de Jong, Esther C.; Schuitemaker, Joost H. N.; Geijtenbeek, Theo B. H.; van Kooyk, Yvette; Kapsenberg, Martien L.; Wierenga, Eddy A.

    2002-01-01

    Th cell polarization toward Th1 or Th2 cells is strongly driven by exogenous cytokines, in particular IL-12 or IL-4, if present during activation by Ag-presenting dendritic cells (DC). However, additional Th cell polarizing mechanisms are induced by the ligation of cell surface molecules on DC and

  12. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... ... such as [14,17]. In [19] this is introduced as atomic verification capability. Here .... 26th ACM Symposium on Theory of Computing,pages 544–553. ACM, 1994. ... Self-tallying elections and perfect ballot secrecy. In Proc. 5th.

  13. 13th International Congress on Polymers in Concrete

    OpenAIRE

    Aguiar, J. L. Barroso de, ed. lit.; Jalali, Said, ed. lit.; Camões, Aires, ed. lit; Ferreira, Rui Miguel, ed. lit.; International Congress on Polymers in Concrete, 13, Madeira, 2010

    2010-01-01

    The 13th International Congress on Polymers in Concrete 2010 (13th ICPIC 2010) follows a series of 12 earlier successful congresses, which has been started in London in 1975. These congresses, being held every three years, played a key role in disseminating R&D findings between researchers, academics, industrials and students. The 13th ICPIC was again a forum to exchange knowledge and most recent research findings among participants. It represented a contribution to the development of this im...

  14. 12th International Conference on Software Engineering, Arti fi cial Intelligence Research, Management and Applications (SERA 2014)

    CERN Document Server

    Software Engineering Research, Management and Applications

    2015-01-01

    This edited book presents scientific results of the 12th International Conference on Software Engineering, Artificial Intelligence Research, Management and Applications (SERA 2014) held on August 31 – September 4, 2014 in Kitakyushu, Japan.  The aim of this conference was to bring together researchers and scientists, businessmen and entrepreneurs, teachers, engineers, computer users, and students to discuss the numerous fields of computer science and to share their experiences and exchange new ideas and information in a meaningful way. Research results about all aspects (theory, applications and tools) of computer and information science, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them. This publication captures 17 of the conference’s most promising papers.

  15. 12th DESY Workshop on Elementary Particle Physics: Loops and Legs in Quantum Field Theory

    CERN Document Server

    LL2014

    2014-01-01

    The bi-annual international conference “Loops and Legs in Quantum Field Theory” has been held at Weimar, Germany, from April 27 to May 02, 2014. It has been the 12th conference of this series, started in 1992. The main focus of the conference are precision calculations of multi- loop and multi-leg processes in elementary particle physics for processes at present and future high-energy facilities within and beyond the Standard Model. At present many physics questions studied deal with processes at the LHC and future facilities like the ILC. A growing number of contributions deals with important developments in the field of computational technologies and algorithmic methods, including large-scale computer algebra, efficient methods to compute large numbers of Feynman diagrams, analytic summation and integration methods of various kinds, new related function spaces, precise numerical methods and Monte Carlo simulations. The present conference has been attended by more than 110 participants from all over the ...

  16. Magnetoresistance effect in perovskite-like RCu3Mn4O12 (R - rare earth ion, Th)

    International Nuclear Information System (INIS)

    Lobanovskij, L.S.; Troyanchuk, I.O.; Trukhanov, S.V.; Pastushonok, S.N.; Pavlov, V.I.

    2003-01-01

    The study on the electric properties and magnetoresistance effect in the RCu 3 Mn 4 O 12 (where R is the rare-earth ion, Th) is carried out. It is established that all the compositions of the given series demonstrate the magnetoresistive effect, the value whereof at the liquid nitrogen temperature reaches 20% in the field 0.9 T. The increase in the magnetoresistance with the temperature decrease and high sensitivity to the weak magnetic fields at low temperatures indicate that this effect is intergranular. The peak of the magnetoresistance is identified near the Curie temperature (T C ). It is supposed that the degree of the magnetoresistance near the temperature of the magnetic ordering depends on the conditions of the samples synthesis and the effect of the intergranular interlayer on the transport properties of these compositions [ru

  17. 80th Annual Meeting of the Psychometric Society

    CERN Document Server

    Bolt, Daniel; Wang, Wen-Chung; Douglas, Jeffrey; Wiberg, Marie

    2016-01-01

    The research articles in this volume cover timely quantitative psychology topics, including new methods in item response theory, computerized adaptive testing, cognitive diagnostic modeling, and psychological scaling. Topics within general quantitative methodology include structural equation modeling, factor analysis, causal modeling, mediation, missing data methods, and longitudinal data analysis. These methods will appeal, in particular, to researchers in the social sciences. The 80th annual meeting took place in Beijing, China, between the 12th and 16th of July, 2014. Previous volumes to showcase work from the Psychometric Society’s Meeting are New Developments in Quantitative Psychology: Presentations from the 77th Annual Psychometric Society Meeting (Springer, 2013), Quantitative Psychology Research: The 78th Annual Meeting of the Psychometric Society (Springer, 2015), and Quantitative Psychology Research: The 79th Annual Meeting of the Psychometric Society, Wisconsin, USA, 2014 (Springer, 2015).

  18. Synthesis and structural characterization of CsNiP crystal

    Indian Academy of Sciences (India)

    Unknown

    The crystals obtained by this method were of good quality exhibiting ... type framework structure having Cs atoms inside it (figures. 3 and 4). This helps for .... Gopalakrishna G S, Prasad J S and Lokanath N K 2001 Proc. joint 4th and 6th ICSTR ...

  19. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (13th, Budapest, Hungary, April 10-12, 2017)

    Science.gov (United States)

    Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

    2017-01-01

    These proceedings contain the papers and posters of the 13th International Conference on Mobile Learning 2017, which was organised by the International Association for Development of the Information Society (IADIS), in Budapest, Hungary, April 10-12, 2017. The Mobile Learning 2017 Conference seeks to provide a forum for the presentation and…

  20. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.

    Directory of Open Access Journals (Sweden)

    Chin-Tong Ong

    2008-07-01

    Full Text Available Recent reports suggested that Delta1, 4 and Jagged1, 2 possessed the ability to instruct CD4(+ T cell into selection of Th1 or Th2 fates, respectively, although the underlying mechanism endowing the cleaved Notch receptor with memory of ligand involved in its activation remains elusive. To examine this, we prepared artificial antigen-presenting cells expressing either DLL1 or Jag1. Although both ligands were efficient in inducing Notch2 cleavage and activation in CD4(+ T or reporter cells, the presence of Lunatic Fringe in CD4(+ T cells inhibited Jag1 activation of Notch1 receptor. Neither ligand could induce Th1 or Th2 fate choice independently of cytokines or redirect cytokine-driven Th1 or Th2 development. Instead, we find that Notch ligands only augment cytokine production during T cell differentiation in the presence of polarizing IL-12 and IL-4. Moreover, the differentiation choices of naïve CD4(+ T cells lacking gamma-secretase, RBP-J, or both in response to polarizing cytokines revealed that neither presenilin proteins nor RBP-J were required for cytokine-induced Th1/Th2 fate selection. However, presenilins facilitate cellular proliferation and cytokine secretion in an RBP-J (and thus, Notch independent manner. The controversies surrounding the role of Notch and presenilins in Th1/Th2 polarization may reflect their role as genetic modifiers of T-helper cells differentiation.

  1. Electrochemical reactions of the Th4+/Th couple on the tungsten, aluminum and bismuth electrodes in chloride molten salt

    International Nuclear Information System (INIS)

    Liu, Kui; Yuan, Li-Yong; Liu, Ya-Lan; Zhao, Xiu-Liang; He, Hui; Ye, Guo-An; Chai, Zhi-Fang; Shi, Wei-Qun

    2014-01-01

    This work concerns the electrochemical behaviors of Th 4+ on the tungsten, aluminum and bismuth electrodes in the LiCl-KCl eutectic, respectively, at 773 K. Cyclic voltammetry and square wave voltammetry were employed to investigate the cathodic reduction of Th 4+ . The results demonstrate that the reduction of Th 4+ is a one step process with a transfer of 4 electrons. The reversibility of the Th 4+ /Th couple on the bismuth film and tungsten electrodes is directly confirmed by the CV. The diffusion coefficient is also calculated to be (2.23 ± 0.16) × 10 −5 and (7.19 ± 0.12) × 10 −5 cm 2 /s by applying both cyclic voltammetry and chronopotentiometry, respectively. A series of redox couples were confirmed to be associated with the formation of different kinds of Al-Th intermetallic compounds. Compared to Al electrode, a cathodic shift of the reduction potential of the Th 4+ is observed on the Al film electrode which is not conducive for the potentiostatic extraction of thorium. The cathodic depolarization gives a shift of 420 mV on the Al electrode, while 490 mV on the Bi film electrode for the reduction of Th 4+ compared to the inert W electrode. The reduction potential of Th 4+ on the Bi film electrode is 70 mV more anodic than that on the Al electrode. Potentiostatic electrolyses were carried out on an Al plate and Bi liquid electrode to confirm the formation of the Th alloys. Two Al-Th alloys (Al 3 Th and Al 2 Th) and one Bi-Th alloy (Bi 2 Th) were obtained, respectively

  2. ThMn12-type phases for magnets with low rare-earth content: Crystal-field analysis of the full magnetization process.

    Science.gov (United States)

    Tereshina, I S; Kostyuchenko, N V; Tereshina-Chitrova, E A; Skourski, Y; Doerr, M; Pelevin, I A; Zvezdin, A K; Paukov, M; Havela, L; Drulis, H

    2018-02-26

    Rare-earth (R)-iron alloys are a backbone of permanent magnets. Recent increase in price of rare earths has pushed the industry to seek ways to reduce the R-content in the hard magnetic materials. For this reason strong magnets with the ThMn 12  type of structure came into focus. Functional properties of R(Fe,T) 12 (T-element stabilizes the structure) compounds or their interstitially modified derivatives, R(Fe,T) 12 -X (X is an atom of hydrogen or nitrogen) are determined by the crystal-electric-field (CEF) and exchange interaction (EI) parameters. We have calculated the parameters using high-field magnetization data. We choose the ferrimagnetic Tm-containing compounds, which are most sensitive to magnetic field and demonstrate that TmFe 11 Ti-H reaches the ferromagnetic state in the magnetic field of 52 T. Knowledge of exact CEF and EI parameters and their variation in the compounds modified by the interstitial atoms is a cornerstone of the quest for hard magnetic materials with low rare-earth content.

  3. Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis

    Science.gov (United States)

    Sallin, Michelle A.; Sakai, Shunsuke; Kauffman, Keith D.; Young, Howard A.; Zhu, Jinfang; Barber, Daniel L.

    2017-01-01

    SUMMARY Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1 polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL-12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of CD69+CD103+ tissue resident phenotype effectors in lung. In contrast, Th1 cell-derived IFNγ inhibits the accumulation of intravascular CX3CR1+KLRG1+ Th1 cells. Thus, although IL-12 and T-bet are essential host survival factors, they simultaneously oppose lung CD4 T cell responses at several levels, demonstrating the dual nature of Th1 polarization in tuberculosis. PMID:28355562

  4. 12th International School of Mathematics "G Stampacchia" : Applied Mathematics in the Aerospace Field "Ettore Majorana"

    CERN Document Server

    Salvetti, Attilio; Applied Mathematics in Aerospace Science and Engineering

    1994-01-01

    This book contains the proceedings ofthe meeting on "Applied Mathematics in the Aerospace Field," held in Erice, Sicily, Italy from September 3 to September 10, 1991. The occasion of the meeting was the 12th Course of the School of Mathematics "Guido Stampacchia," directed by Professor Franco Giannessi of the University of Pisa. The school is affiliated with the International Center for Scientific Culture "Ettore Majorana," which is directed by Professor Antonino Zichichi of the University of Bologna. The objective of the course was to give a perspective on the state-of­ the-art and research trends concerning the application of mathematics to aerospace science and engineering. The course was structured with invited lectures and seminars concerning fundamental aspects of differential equa­ tions, mathematical programming, optimal control, numerical methods, per­ turbation methods, and variational methods occurring in flight mechanics, astrodynamics, guidance, control, aircraft design, fluid mechanic...

  5. The 12th June 2017 Mw = 6.3 Lesvos earthquake from detailed seismological observations

    Science.gov (United States)

    Papadimitriou, P.; Kassaras, I.; Kaviris, G.; Tselentis, G.-A.; Voulgaris, N.; Lekkas, E.; Chouliaras, G.; Evangelidis, C.; Pavlou, K.; Kapetanidis, V.; Karakonstantis, A.; Kazantzidou-Firtinidou, D.; Fountoulakis, I.; Millas, C.; Spingos, I.; Aspiotis, T.; Moumoulidou, A.; Skourtsos, E.; Antoniou, V.; Andreadakis, E.; Mavroulis, S.; Kleanthi, M.

    2018-04-01

    A major earthquake (Mwö=ö6.3) occurred on the 12th of June 2017 (12:28 GMT) offshore, south of the SE coast of Lesvos Island, at a depth of 13ökm, in an area characterized by normal faulting with an important strike-slip component in certain cases. Over 900 events of the sequence between 12 and 30 June 2017 were manually analyzed and located, employing an optimized local velocity model. Double-difference relocation revealed seven spatially separated groups of events, forming two linear branches, roughly aligned N130°E, compatible with the strike of known mapped faults along the southern coast of Lesvos Island. Spatiotemporal analysis indicated gradual migration of seismicity towards NW and SE from the margins of the main rupture, while a strong secondary sequence at a separate fault patch SE of the mainshock, oriented NW-SE, was triggered by the largest aftershock (Mwö=ö5.2) that occurred on 17 June. The focal mechanisms of the mainshock (φö=ö122°, δö=ö40° and λö=ö-83°) and of the major aftershocks were determined using regional moment tensor inversion. In most cases normal faulting was revealed with the fault plane oriented in a NW-SE direction, dipping SW, with the exception of the largest aftershock that was characterized by strike-slip faulting. Stress inversion revealed a complex stress field south of Lesvos, related both to normal, in an approximate E-W direction, and strike-slip faulting. All aftershocks outside the main rupture, where gradual seismicity migration was observed, are located within the positive lobes of static stress transfer determined by applying the Coulomb criterion for the mainshock. Stress loading on optimal faults under a strike-slip regime explains the occurrence of the largest aftershock and the seismicity that was triggered at the eastern patch of the rupture zone.

  6. Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn's Disease Mouse Model.

    Science.gov (United States)

    Lv, Qing-Kang; Liu, Ju-Xiong; Li, Su-Nan; Gao, Ying-Jie; Lv, Yan; Xu, Zi-Peng; Huang, Bing-Xu; Xu, Shi-Yao; Yang, Dong-Xue; Zeng, Ya-Long; Liu, Dian-Feng; Wang, Wei

    2015-11-06

    Mycophenolate mofetil (MMF) is an alternative immunosuppressive agent that has been reported to be effective and well tolerated for the treatment of refractory inflammatory bowel disease (IBD). The aim of this study was to investigate the therapeutic effect of MMF on intestinal injury and tissue inflammation, which were caused by Crohn's disease (CD). Here, trinitrobenzene sulfonic acid-relapsing (TNBS) colitis was induced in mice; then, we measured the differentiation of Th1/Th2 cells in mouse splenocytes by flow cytometry and the secretion of cytokines in mice with TNBS-induced colitis by real-time polymerase chain reaction and/or enzyme-linked immunosorbent assay (RT-PCR/ELISA). The results show that MMF significantly inhibited mRNA expression of pro-inflammatory cytokines IFN-γ, TNF-α, IL-12, IL-6, and IL-1β in mice with TNBS-induced colitis; however, MMF did not inhibit the expression of IL-10 mRNA. Additionally, ELISA showed that the serum levels of IFN-γ, TNF-α, IL-12, IL-6, and IL-1β were down-regulated in a TNBS model of colitis. Flow cytometric analysis showed MMF markedly reduced the percentages of Th1 and Th2 splenocytes in the CD mouse model. Mycophenolic acid (MPA) also significantly decreased the percentages of splenic Th1 and Th2 cells in vitro. Furthermore, MMF treatment not only significantly ameliorated diarrhea, and loss of body weight but also abrogated the histopathologic severity and inflammatory response of inflammatory colitis, and increased the survival rate of TNBS-induced colitic mice. These results suggest that treatment with MMF may improve experimental colitis and induce inflammatory response remission of CD by down-regulation of pro-inflammatory cytokines via modulation of the differentiation of Th1/Th2 cells.

  7. Aprenentatge cooperatiu interdisciplinari i rúbriques per a la millora del procés d'ensenyament-aprenentatge

    Directory of Open Access Journals (Sweden)

    Beatriz Corchuelo Martínez-Azúa

    2016-06-01

    Full Text Available L'adaptació dels títols a l'Espai Europeu d'Educació Superior (EEES suposa l'ocasió de millorar l'educació integral dels alumnes, orientant les accions docents cap al desenvolupament de competències. L'adquisició de competències exigeix la incorporació de metodologies docents actives que permetin la generació enfront de la mera transmissió de coneixements. Així mateix, nombrosos estudis adverteixen de l'escassa transferència existent en els coneixements tractats en les assignatures quan es consideren de manera individual. El treball interdisciplinari constitueix una valuosa eina perquè els estudiants facin connexions, plantegin i trobin respostes a situacions problemàtiques i ajustin el seu aprenentatge a un coneixement integral. Pel que s'ha vist la necessitat de desenvolupar, en el currículum formatiu de l'alumne, aproximacions interdisciplinàries.Tenint en compte aquests aspectes, s'ha realitzat una experiència d'innovació docent universitària de caràcter interdisciplinari en la qual s'integren els continguts i competències de diverses assignatures per abordar el procés de solució de problemes econòmics. S'ha treballat la interdisciplinaritat amb tècniques d'aprenentatge cooperatiu. La interacció d’aquests aspectes és la raó por la quual hem denominat a l'experiència “Aprenentatge Cooperatiu Interdisciplinari” (ACI. L'avaluació de l'aprenentatge es realitza de forma individual, (mitjançant heteroevaluació i coevaluació, i grupal, (mitjançant rúbriques i coevaluació.Els resultats mostren diversos aspectes: 1 La metodologia ACI no solament permet formar en continguts sinó també en competències. 2 La interconnexió entre assignatures ha permès que els alumnes ajuste n els seus aprenentatges cap a un coneixement més integral. 3 La unió de les diferents innovacions docents ha repercutit positivament en la motivació de l'alumnat. 4 S'han assolit resultats d'aprenentatge positius en l'alumnat, majors

  8. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (12th, Vilamoura, Algarve, Portugal, April 9-11, 2016)

    Science.gov (United States)

    Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

    2016-01-01

    These proceedings contain the papers of the 12th International Conference on Mobile Learning 2016, which was organized by the International Association for Development of the Information Society, in Vilamoura, Algarve, Portugal, April 9-11, 2016. The Mobile Learning 2016 Conference seeks to provide a forum for the presentation and discussion of…

  9. A Study of Learning Achievement and Learning Behavior in Biology on “Genes and Chromosomes” Using Storyline Teaching for 12th Grade Students

    OpenAIRE

    Ubonwan Leawudomchai; Kittima Panprueksa; Somsiri Singlop; Thanawuth Latwong

    2016-01-01

    The objectives of this research were to study learning achievement and learning behavior in Biology on “genes and chromosomes” using storyline teaching for 12th grade students. The sample for this research consisted of 36 twelfth grade students from Piboonbumpen Demonstration School in the first semester of 2014. The sample was randomly selected for the experimental group using cluster random sampling. The research instruments were the lesson plans using storyline teaching on g...

  10. 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity and 9th International Conference on Functional Materials and Nanotechnologies (RCBJSF–2014–FM and NT)

    International Nuclear Information System (INIS)

    Sternberg, Andris; Grinberga, Liga; Sarakovskis, Anatolijs; Rutkis, Martins

    2015-01-01

    The joint International Symposium RCBJSF–2014–FM and NT successfully has united two international events – 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity (RCBJSF-12) and 9th International Conference Functional Materials and Nanotechnologies (FM and NT-2014). The RCBJSF symposium is a continuation of series of meetings on ferroelectricity, the first of which took place in Novosibirsk (USSR) in 1976. FM and NT conferences started in 2006 and have been organized by Institute of Solid State Physics, University of Latvia in Riga. In 2012 the International program committee decided to transform this conference into a traveling Baltic State conference and the FM and NT-2013 was organized by the Institute of Physics, University of Tartu, Estonia. In 2014 the joint international symposium RCBJSF–2014–FM and NT was organized by the Institute of Solid State Physics, University of Latvia and was part of Riga – 2014, the European Capital of Culture event. The purpose of the joint Symposium was to bring together scientists, students and high-level experts in solid state physics, materials science, engineering and related disciplines. The number of the registered participants from 26 countries was over 350. During the Symposium 128 high quality scientific talks (5 plenary, 42 invited, 81 oral) and over 215 posters were presented. All presentations were divided into 4 parallel sessions according to 4 main topics of the Symposium: Ferroelectricity, including ferroelectrics and multiferroics, pyroelectrics, piezoelectrics and actuators, integrated ferroelectrics, relaxors, phase transitions and critical phenomena. Multifunctional Materials, including theory, multiscale and multiphenomenal material modeling and simulation, advanced inorganic, organic and hybrid materials. Nanotechnologies, including progressive methods, technologies and design for production, investigation of nano- particles, composites, structures, thin films and coatings. Energy, including

  11. EDITORIAL: Proceedings of the 12th Gravitational Wave Data Analysis Workshop (GWDAW 12), Cambridge, MA, USA, 13 16 December 2007

    Science.gov (United States)

    Hughes, S.; Katsavounidis, E.

    2008-09-01

    It was a great pleasure and an honor for us to host the 12th Gravitational Wave Data Analysis Workshop (GWDAW) at MIT and the LIGO Laboratory in Cambridge, Massachusetts, the place where this workshop series started in 1996. This time the conference was held at the conference facilities of the Royal Sonesta Hotel in Cambridge from 13 16 December, 2007. This 12th GWDAW found us with the ground interferometers having just completed their most sensitive search for gravitational waves and as they were starting their preparation to bring online and/or propose more sensitive instruments. Resonant mass detectors continued to observe the gravitational wave sky with instruments that have been operating now for many years. LISA, the Laser Interferometer Space Antenna, was recently reviewed by NASA's Beyond Einstein Program Assessment Committee (BEPAC) convened by the National Research Council (NRC) and found that 'on purely scientific grounds LISA is the mission that is the most promising and least scientifically risky…thus, the committee gave LISA its highest scientific ranking'. Even so, JDEM, the Joint Dark Energy Mission, was identified to go first, with LISA following a few years after. New methods, analysis ideas, results from the analysis of data collected by the instruments, as well as Mock Data Challenges for LISA were reported in this conference. While data from the most recent runs of the instruments are still being analyzed, the first upper limit results show how even non-detection statements can be interesting astrophysics. Beyond these traditional aspects of GWDAW though, for the first time in this workshop we tried to bring the non-gravitational wave physics and astronomy community on board in order to present, discuss and propose ways to work together as we pursue the first detection of gravitational waves and as we hope to transition to gravitational wave astronomy in the near future. Overview talks by colleagues leading observations in the electromagnetic

  12. Polarization of T-helper lymphocytes toward the Th2 phenotype in uremic patients.

    Science.gov (United States)

    Libetta, C; Rampino, T; Dal Canton, A

    2001-08-01

    T-helper (Th) lymphocytes consist of Th1 and Th2 subsets. Th1 cells are effectors of cell-mediated immunity and secrete interferon-gamma (IFN-gamma), which recruits new Th1 cells in cooperation with interleukin-12 (IL-12; produced by monocytes) and inhibits Th2 differentiation. Th2 cells produce IL-4 and IL-10, which inhibit IFN-gamma secretion and cell immunity. We investigated whether the impaired immune response in uremia is associated with an altered balance of Th1/Th2. Peripheral-blood mononuclear cells (PBMCs) were collected from patients with chronic renal failure (CRF) on conservative treatment (CRF patients), patients with end-stage renal disease (ESRD) on regular hemodialysis therapy (ESRD-HD patients), and healthy controls (CON). CD4(+) cells were isolated from PBMCs by negative selection using a magnetic labeling system. PBMCs and purified CD4(+) cells were cultured in Iscove's medium and Iscove's medium plus mitogens (phytohemagglutinin and lipopolysaccharide). IFN-gamma, IL-12, IL-4, and IL-10 were measured in supernatant. The constitutive release of IL-4 and IL-10 by PBMCs and CD4(+) cells of CRF and ESRD-HD patients was increased by five to eight times in comparison with CON (P CON, 115.8 pg/2 x10(6) cells; CRF, 81.8 pg/2 x10(6) cells; ESRD-HD, 9.3 pg/2 x10(6) cells; CD4(+) cells: CON, 358.0 pg/5 x 10(5) cells; CRF, 165.4 pg/5 x 10(5) cells; ESRD-HD, 43.5 pg/5 x 10(5) cells). The ability of PBMCs of ESRD-HD patients to secrete IFN-gamma was recovered after IL-4 and IL-10 neutralization. Uremia is associated with a prevalence of Th1 over Th2 cells and a configuration of cytokine network that depresses cell-mediated immunity.

  13. Ristripatsid Eesti 12.–13. sajandi laibakalmistutes: kas ehted või usu tunnused? / The cross-shaped pendants of inhumation burials in 12th-13th century Estonia: adornments or signs of belief?

    Directory of Open Access Journals (Sweden)

    Tuuli Kurisoo

    2012-01-01

    Full Text Available Cross-shaped pendants are one of the most discussed symbolically laden artefacts among Estonian archaeological material. The beginning of the distribution of cross-shaped pendants dates back to 11th century when the artefacts, though scarce, appear. The number of such pendants increases noticeably at the very end of the Iron Age. Due to the ambiguous entity of cross and time context, cross-pendants have been interpreted either as symbols of Christian faith, as pieces of adornment not affiliated with Christianity, or as objects with magical qualities. In this paper I study pendants found in the inhumation cemeteries of Estonia. Only those provide us with an archaeological context which shows precisely who could have worn them and how. The analyzed cross-pendants were found at Pada, Kaberla, Kukruse, Haimre and Tammiku cemeteries and from the early burials in Viru-Nigula churchyard. As artefacts, the cross pendants are more or less stylized Greek crosses. In most cases the pendants were either used as a part of jewellery or worn singularly around the neck area. From the total of 48 analyzed cross-pendants one fourth could be interpreted as locally produced items. Of local origin are probably lead pendants from Pada cemetery, heads of decorative pins worn as cross-shaped pendants from Viru-Nigula and Kaberla cemeteries, and obvious scrap and unfinished pendant crosses. In addition, I would like to draw attention that cross-pendants from inhumation burials do not contain many widespread forms, such as ‘Scandinavian’ and some other widespread Russian origin types, which have been found in hoards, from hill-forts and cremation burials. This observation could confirm that cross pendants from 12th–13th century inhumation burials were communally recognized and some of them were locally manufactured. As the next stage of my investigation I studied different occurrence contexts of cross pendants in cemeteries and burials: the location of burials with

  14. Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

    Science.gov (United States)

    Duechting, Andrea; Przybyla, Anna; Kuerten, Stefanie; Lehmann, Paul V

    2017-09-12

    During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes. Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood mononuclear cells (PBMC) with antigen, and establishing the numbers of T cells producing the respective lead cytokine, IFN-γ and IL-2 for Th1 cells, IL-4 and IL-5 for Th2, and IL-17 for Th-17 cells, respectively. Traditionally, these cytokines are measured within 6 h in flow cytometry. We show here that 6 h of stimulation is sufficient to detect peptide-induced production of IFN-γ, but 24 h are required to reveal the full frequency of protein antigen-specific Th1 cells. Also the detection of IL-2 producing Th1 cells requires 24 h stimulation cultures. Measurements of IL-4 producing Th2 cells requires 48-h cultures and 96 h are required for frequency measurements of IL-5 and IL-17 secreting T cells. Therefore, accounting for the differential secretion kinetics of these cytokines is critical for the accurate determination of the frequencies and ratios of antigen-specific Th1, Th2, and Th17 cells.

  15. Suicidal ideation among students of the 7th, 8th, and 9th grades in the State of Lara, Venezuela: the Global School Health Survey.

    Science.gov (United States)

    Granero, Ricardo; Poni, Esteban; Poni, Carolin

    2008-12-01

    Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. The Global School Health Survey is a self-administered survey done on a random probabilistic sample among students of the 7th, 8th, and 9th grades in the Lara State, Venezuela, school period 2003 to 2004. Point prevalence of SI and associated factors were included and the odds (OR) of having SI was calculated given selected factors. Two-thousand seventy (2070) respondents, of which 13.5 % reported having SI in the last 12 months, and in females more than males (14.6% vs. 11.7%). The OR for SI, according to an associated risk factor, were among (a) females: age > or = 14 years (2.2), worries (3.42), loneliness (8.8), ever had sexual intercourse (5.58), alcohol (8.43) and (b) males: having only one or non close friends (3.69), alcohol (12.36), ever had sexual intercourse (2.73). Behavioral risk factors are relatively new in the field of surveillance systems; therefore, results on SI should be cautiously taken into consideration and a wide discussion should be encouraged as we learn how to best use the results for health promotion and disease prevention.

  16. Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.

    Science.gov (United States)

    Chen, Xuemei; Wang, Junfu; Wang, Rui; Su, Qinghong; Luan, Junwen; Huang, Haiyan; Zhou, Peng; Liu, Jinsheng; Xu, Xiaoqun

    2016-02-01

    Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.

  17. Thermophysical properties of Na2Th (MoO4)3 (s) and Na4Th (MoO4)4 (s)

    International Nuclear Information System (INIS)

    Dash, Smruti; Rakshit, S.K.; Singh, Ziley; Keskar, Meera; Dahale, N.D.

    2009-01-01

    The heat capacity of Na 2 Th (MoO 4 ) 3 (s) and Na 4 Th (MoO 4 ) 4 (s) have been measured by differential scanning calorimeter in the temperature range 318 to 845 K. The corresponding values are: C p,m (Na 2 Th (MoO 4 ) 3 ,s,T) (JK-1 mol-1) 368.710+ 1.0 10-1 (T/K) - 4950267 (K/T)2 (318 ≤ T (K) ≤ 845). C p,m (Na 4 Th (MoO 4 ) 4 ,s,T) (JK-1 mol-1) = 638.761+ 5.12 10-3 (T/K) - 12691691 (K/T)-2 (318 ≤ T (K) ≤ 845). Experimental heat capacity values for Na 2 Th (MoO 4 ) 3 (s) match reasonably well with that of additive oxide values. But C p,m (T) values of Na 4 Th (MoO 4 ) 4 (s) deviates substantially from the additive oxide values above 700 K. The uncertainty of the measurements reported in this study is calculated to be within 1 to 3 % . (author)

  18. ONR Tokyo Scientific Bulletin. Volume 5, Number 4, October-December 1980

    Science.gov (United States)

    1980-12-01

    long been of great Importance to both the rulers and the people of the subcontinent. Even today, among many educated people, horoscopes determine the...the Kyodai (Kyoto University) school. Th view is quite true but Japanese oceanographers are reluctant to admit it. According to a UNESCO document, the

  19. Performance Analysis of Compositional and Modified Black-Oil Models For a Gas Lift Process Analyse des performances de modèles black-oil pour le procédé d’extraction par injection de gaz

    Directory of Open Access Journals (Sweden)

    Mahmudi M.

    2013-03-01

    Full Text Available Artificial gas lift is frequently used to boost production rate of mature oil fields. An integrated mathematical model was developed in order to track the spatial and temporal changes in various components of the continuous gas lift process. The computational demand for solving the comprehensive gas lift model highly depends on the thermodynamic treatment of the hydrocarbon fluids involved. A full compositional treatment using an equation of state provides the most accurate results but at a high computational cost. The results of this article showed that the computational cost can be halved without sacrificing accuracy by using reduced parameter stability and flash calculation procedures. It was also demonstrated that a Modified Black-Oil treatment of the fluids can provide reasonable accuracy at a much-reduced computational cost. The Modified Black-Oil treatment provides a valuable tool when the model has to be solved many hundreds of times to find the optimal combination of the gas lift parameters. Les procédés artificiels d’extraction par injection de gaz sont utilisés pour améliorer le taux de récupération des champs pétroliers matures. Un modèle mathématique intégré a été développé pour détecter de faibles changements temporels et spatiaux dans plusieurs composants des procédés continus d’extraction par injection de gaz. La solution numérique utilisée pour résoudre le modèle du procédé d’extraction dépend fortement du comportement thermodynamique des hydrocarbures impliqués. Un traitement complet de la composition utilisant une équation d’état offre les résultats les plus précis, mais à un coût de calcul très élevé. Les résultats de nos travaux de recherche montrent que l’implication des paramètres de stabilité et des procédures de calcul flash, peut diviser par deux le coût du calcul tout en gardant la précision attendue. Ces travaux montrent que la précision admissible peut être

  20. 18th Asia Pacific Symposium on Intelligent and Evolutionary Systems

    CERN Document Server

    Ishibuchi, Hisao; Ong, Yew-Soon; Tan, Kay-Chen

    2015-01-01

    This book contains a collection of the papers accepted in the 18th Asia Pacific Symposium on Intelligent and Evolutionary Systems (IES 2014), which was held in Singapore from 10-12th November 2014. The papers contained in this book demonstrate notable intelligent systems with good analytical and/or empirical results.

  1. PRO-C3-levels in patients with HIV/HCV-Co-infection reflect fibrosis stage and degree of portal hypertension

    DEFF Research Database (Denmark)

    Jansen, Christian; Leeming, Diana J; Mandorfer, Mattias

    2014-01-01

    BACKGROUND: Liver-related deaths represent the leading cause of mortality among patients with HIV/HCV-co-infection, and are mainly related to complications of fibrosis and portal hypertension. In this study, we aimed to evaluate the structural changes by the assessment of extracellular matrix (ECM......) derived degradation fragments in peripheral blood as biomarkers for fibrosis and portal hypertension in patients with HIV/HCV co-infection. METHODS: Fifty-eight patients (67% male, mean age: 36.5 years) with HIV/HCV-co-infection were included in the study. Hepatic venous pressure gradient (HVPG......4M and C5M levels were higher in patients with portal hypertension (HVPG>5 mmHg). CONCLUSION: PRO-C3 levels reflect liver injury, stage of liver fibrosis and degree of portal hypertension in HIV/HCV-co-infected patients. Furthermore, C4M and C5M were associated with increased portal pressure...

  2. Extraction of Th and U from Swiss granites

    International Nuclear Information System (INIS)

    Bajo, C.

    1980-12-01

    The extraction, at the laboratory level, of U and Th from Swiss granites is discussed. The Mittagfluh, Bergell and Rotondo granites and the Giuv syenite offered a wide range of U and Th concentrations; 7.7 to 20.0 ppm U and 25.5 to 67.0 ppm Th. U and Th were determined in the leach solutions by the fission track method and by spectrophotometry, respectively. Samples containing less than 0.3 μg U and 4 μg Th, could be measured with an accuracy of 10% for U and 5% for Th. Leach tests were performed during which the following parameters were varied: granite-type, grain size, acid-type, acid concentration, temperature and time. There were very great leaching differences between the granites studied. Temperature was the most important parameter. Sharp differences in extraction occurred between 20 0 C, 50 0 C and 80 0 C. At 80 0 C, more than 85% U and Th were extracted. The extraction curve (percent extracted as a function of time) of aliquots sampled after 1, 2, 4, 8, 12 and 24 hours showed a plateau after 8 hours. The half life of the reaction was between one and two hours. As a general rule, Th was better extracted than U. (Auth.)

  3. Direct Measurement of Initial 230TH/ 232TH Ratios in Central Texas Speleothems for More Accurate Age Determination

    Science.gov (United States)

    Wortham, B. E.; Banner, J. L.; James, E.; Loewy, S. L.

    2013-12-01

    , 14.6 × 0.83 ppm, 5.8 × 0.56 ppm, and 5.9 × 0.60 ppm, which are higher and more precise than the value commonly assumed for initial 230Th/232Th, 4.4 × 4.4 ppm. Soil sampled above Westcave, a potential source of detrital Th incorporated into speleothems, also has a high calculated 230Th/232Th. We calculate soil 230Th/232Th from measured U and Th concentrations of soil leachates (using DI water and ammonium acetate). Calculated 230Th/232Th for Westcave soils range from 0.39 to 28.4 ppm, which encompasses the range of initial 230Th/232Th values found in the modern calcite. Soil leachates from Natural Bridge Caverns and Inner Space Cavern were analyzed by the same method, yielding calculated 230Th/232Th ranging from 1.5 to 12.6 ppm (Natural Bridge), and from 1.43 to 272 ppm (Inner Space). Soil and calcite data indicate that the commonly assumed initial 230Th/232Th is not always applicable and that initial 230Th/232Th can be estimated more accurately by measuring Th isotope ratios in modern calcite and soils to determine speleothem U-series ages.

  4. Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis.

    Science.gov (United States)

    Sallin, Michelle A; Sakai, Shunsuke; Kauffman, Keith D; Young, Howard A; Zhu, Jinfang; Barber, Daniel L

    2017-03-28

    Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73 + CXCR3 + T-bet dim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL- 12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1 + KLRG1 + Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of CD69 + CD103 + tissue resident phenotype effectors in lung. In contrast, Th1-cell-derived IFN-γ inhibits the accumulation of intravascular CX3CR1 + KLRG1 + Th1 cells. Thus, although IL-12 and T-bet are essential host survival factors, they simultaneously oppose lung CD4 T cell responses at several levels, demonstrating the dual nature of Th1 polarization in tuberculosis. Published by Elsevier Inc.

  5. Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis

    Directory of Open Access Journals (Sweden)

    Michelle A. Sallin

    2017-03-01

    Full Text Available Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL- 12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of CD69+CD103+ tissue resident phenotype effectors in lung. In contrast, Th1-cell-derived IFN-γ inhibits the accumulation of intravascular CX3CR1+KLRG1+ Th1 cells. Thus, although IL-12 and T-bet are essential host survival factors, they simultaneously oppose lung CD4 T cell responses at several levels, demonstrating the dual nature of Th1 polarization in tuberculosis.

  6. Effect of sintering atmosphere on the hardness of ThO_2

    International Nuclear Information System (INIS)

    Baena, Angela; Cardinaels, Thomas; Van Eyken, Jelle; Puzzolante, Jean Louis; Binnemans, Koen; Verwerft, Marc

    2016-01-01

    The hardness and toughness of ThO_2 sintered under reducing and oxidizing conditions has been investigated and, quite unexpectedly, a significant difference in hardness was observed for the entire range of porosities studied. Reducing conditions systematically yielded higher hardness values than oxidizing conditions. Extrapolated to zero porosity, the hardness for ThO_2 is H_0 = 10.5 ± 0.3 GPa for oxidizing conditions and H_0 = 12.4 ± 0.7 GPa for reducing conditions. Toughness values have been derived from Vickers indentations; differences in toughness were insignificant and only a single value is proposed: K_I_C = 0.97 ± 0.12 MPa √m. The difference in hardness is attributed to the presence of point defects, also acting as color centers and causing grey coloration of ThO_2 sintered under reducing conditions. Furthermore, and of interest for nuclear fuel production, is the finding that ThO_2 sintered under reducing conditions is significantly easier to grind compared to material sintered under oxidizing conditions. - Highlights: • Reducing sintering conditions increase the hardness of polycrystalline ThO_2. • Systematic series of hardness versus porosity of ThO_2 were obtained. • Reducing sintering conditions improve grinding of ThO_2.

  7. Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

    NARCIS (Netherlands)

    Muller, M.J; Baracos, V.; Bosy-Westphal, A.; Dulloo, A.G.; Eckel, J.; Fearon, K.C.H.; Hall, K.D.; Pietrobelli, A.; Sorensen, T.I.A.; Speakman, J.; Trayhurn, P.; Visser, M.; Heymsfield, S.B.

    2014-01-01

    The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo

  8. Effect of sintering atmosphere on the hardness of ThO2

    Science.gov (United States)

    Baena, Angela; Cardinaels, Thomas; Van Eyken, Jelle; Puzzolante, Jean Louis; Binnemans, Koen; Verwerft, Marc

    2016-08-01

    The hardness and toughness of ThO2 sintered under reducing and oxidizing conditions has been investigated and, quite unexpectedly, a significant difference in hardness was observed for the entire range of porosities studied. Reducing conditions systematically yielded higher hardness values than oxidizing conditions. Extrapolated to zero porosity, the hardness for ThO2 is H0 = 10.5 ± 0.3 GPa for oxidizing conditions and H0 = 12.4 ± 0.7 GPa for reducing conditions. Toughness values have been derived from Vickers indentations; differences in toughness were insignificant and only a single value is proposed: KIC = 0.97 ± 0.12 MPa √m. The difference in hardness is attributed to the presence of point defects, also acting as color centers and causing grey coloration of ThO2 sintered under reducing conditions. Furthermore, and of interest for nuclear fuel production, is the finding that ThO2 sintered under reducing conditions is significantly easier to grind compared to material sintered under oxidizing conditions.

  9. Assessment of furnaces including fuel storage facilities according to the 12th Federal Emission Control Ordinance (BImSchV)

    International Nuclear Information System (INIS)

    Hensler, G.; Ott, H.; Wunderlich, O.; Mair, K.

    1990-01-01

    Existing quantities of substances pursuant to Annex II of the 12th Federal Emission Control Ordinance in furnaces or in fuel storage facilities do not present a general hazard for fireplaces fired with coal, wood, heavy and light fuel oil within the meaning of the Accident Ordinance. In case of a fire in a storage facility for black coal, brown coal, untreated wood, light and heavy fuel oil, a general hazard on account of the release of developed substances is obviously excluded. Dispersion calculations pursuant to VDI 3783 have shown that concentrations of beryllium, arsenic, nickel, cobalt and mercury compounds in the vicinity of the fire source are so small that a general hazard can be excluded. (orig./DG) [de

  10. Differential diagnosis of the 4th ventricular tumors

    International Nuclear Information System (INIS)

    Lee, Sang Woo; Lee, Jong Min; Kang, Moo Song; Kim, Chul Min; Kim, Chang Soo

    1997-01-01

    To determine by analysis of MR and CT findings the points of differentiation among 4th ventricular tumors, especially the change of shape of the 4th ventricle caused by the site at which 4th ventricular tumors originate. The authors retrospectively analyzed and compared the CT(n=5) and MRI(n=12) findings of 13 pathologically proven 4th ventricular tumors comprising six medulloblastomas three ependymomas(4 cases) and three choroids plexus papillomas. On axial MRI medulloblastomas showed anterior and anterolateral CSF-clefts between the tumor mass and the 4th ventricular wall in one and five cases, respectively; on sagittal MRI, anterior beaking of the upper 4th ventricle was seen. Two ependymomas showed posterolateral CSF-cleft on axial MRI and posterior beaking of the upper 4th ventricle on sagittal MRI. Two ependymomas and all choroids plexus papillomas showed anterior, posterior and lateral CSF-clefts on axial MRI, and anterior and posterior beakings of the upper 4th ventricle on sagittal MRI. On Gd-DTPA enhanced T1WI, all medulloblastomas and ependymomas showed inhomogeneous enhancement, and all choroids plexus papillomas showed homogeneous enhancement. On CT, tow choroids plexus papillomas showed dense calcifications. The differential diagnosis of 4th ventricular tumors can be preoperatively suggested by analysis of findings such as a CSF-cleft between the tumor mass and the 4th ventricular wall on axial MR and CT images, the shape of the upper 4th ventricle on sagittal MRI, contrast enhancement pattern, necrosis and cyst, and CSF seeding

  11. Proceedings of the 12th annual meeting of Japanese Society of Radiation Safety Management 2013 Hokkaido

    International Nuclear Information System (INIS)

    2013-11-01

    This is the entitled program and proceedings held from November 27th through 29th of 2013. Focusing on the issues of Fukushima Accident, the sessions including poster, invited/special speeches etc. are risk communication and dose level evaluation, radiation measurement, radioactivity in environment, radioactive cesium kinetics in environment, radioactive material management, environmental contamination and its measures, education on radiation. (J.P.N)

  12. 10th International Symposium on Intelligent Distributed Computing

    CERN Document Server

    Seghrouchni, Amal; Beynier, Aurélie; Camacho, David; Herpson, Cédric; Hindriks, Koen; Novais, Paulo

    2017-01-01

    This book presents the combined peer-reviewed proceedings of the tenth International Symposium on Intelligent Distributed Computing (IDC’2016), which was held in Paris, France from October 10th to 12th, 2016. The 23 contributions address a range of topics related to theory and application of intelligent distributed computing, including: Intelligent Distributed Agent-Based Systems, Ambient Intelligence and Social Networks, Computational Sustainability, Intelligent Distributed Knowledge Representation and Processing, Smart Networks, Networked Intelligence and Intelligent Distributed Applications, amongst others.

  13. Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T. [Instituto de Pesquisas Energeticas e Nucleares, Av. Lineu Prestes, 2242, Caixa Postal 05508-000, Cidade Universitaria, Sao Paulo (Brazil)]. e-mail: Pscsilva@ipen.br

    2004-07-01

    In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. {sup 232} Th and {sup 228} Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. {sup 232} Th concentration ranged from 6.5 to 198 Bq kg{sup -1} with mean value of 57 {+-} 39 Bq kg{sup -1}, for 42 samples. {sup 228} Th content varied from 12 to 110 Bq kg{sup -1} with a mean value of 74 {+-} 23 Bq kg{sup -1}, for 18 samples. It can be seen that the amount of {sup 232} Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

  14. Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

    International Nuclear Information System (INIS)

    Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T.

    2004-01-01

    In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. 232 Th and 228 Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. 232 Th concentration ranged from 6.5 to 198 Bq kg -1 with mean value of 57 ± 39 Bq kg -1 , for 42 samples. 228 Th content varied from 12 to 110 Bq kg -1 with a mean value of 74 ± 23 Bq kg -1 , for 18 samples. It can be seen that the amount of 232 Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

  15. 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems

    Energy Technology Data Exchange (ETDEWEB)

    Berk, Herbert L.; Breizman, Boris N.

    2014-02-21

    The 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems took place in Austin, Texas (7–11 September 2011). This meeting was organized jointly with the 5th IAEA Technical Meeting on Theory of Plasma Instabilities (5–7 September 2011). The two meetings shared one day (7 September 2011) with presentations relevant to both groups. Some of the work reported at these meetings was then published in a special issue of Nuclear Fusion [Nucl. Fusion 52 (2012)]. Summaries of the Energetic Particle Conference presentations were given by Kazuo Toi and Boris Breizman. They respectively discussed the experimental and theoretical progress presented at the meeting. Highlights of this meeting include the tremendous progress that has been achieved in the development of diagnostics that enables the ‘viewing’ of internal fluctuations and allows comparison with theoretical predictions, as demonstrated, for example, in the talks of P. Lauber and M. Osakabe. The need and development of hardened diagnostics in the severe radiation environment, such as those that will exist in ITER, was discussed in the talks of V. Kiptily and V.A. Kazakhov. In theoretical studies, much of the effort is focused on nonlinear phenomena. For example, detailed comparison of theory and experiment on D-III-D on the n = 0 geodesic mode was reported in separate papers by R. Nazikian and G. Fu. A large number of theoretical papers were presented on wave chirping including a paper by B.N. Breizman, which notes that wave chirping from a single frequency may emanate continuously once marginal stability conditions have been established. Another area of wide interest was the detailed study of alpha orbits in a burning plasma, where losses can come from symmetry breaking due to finite coil number or magnetic field imperfections introduced by diagnostic or test modules. An important area of development, covered by M.A. Hole and D.A. Spong, is concerned with the self

  16. Th1 and Th2-like protein balance in human inflammatory radicular cysts and periapical granulomas.

    Science.gov (United States)

    de Carvalho Fraga, Carlos Alberto; Alves, Lucas Rodrigues; de Sousa, Adriana Alkmim; de Jesus, Sabrina Ferreira; Vilela, Daniel Nogueira; Pereira, Camila Santos; Batista Domingos, Patrícia Luciana; Viana, Agostinho Gonçalves; Jham, Bruno Correia; Batista de Paula, Alfredo Maurício; Sena Guimarães, André Luiz

    2013-04-01

    Chronic dental periapical lesions result from chronic inflammation of periapical tissues caused by continuous antigenic stimulation from infected root canals. Recent findings have suggested that T helper (Th) 1 and Th2-like cytokines are important in the pathogenesis of chronic periapical inflammatory diseases. However, the mechanisms regulating these immunoinflammatory pathways have not been fully elucidated. Thus, the aim of this study was to evaluate interleukin (IL)-4, IL-12, and interferon γ (IFN-γ) protein levels in human radicular cysts and periapical granulomas. Archived samples of cysts (n = 52) and granulomas (n = 27) were sectioned and submitted to immunohistochemistry to evaluate the tissue expression of IL-4, IL-12, and IFN-γ. The data were analyzed using the Mann-Whitney U test (P cysts. IL-4 expression was stronger in periapical granulomas than in radicular cysts. IL-12 was not detected in any of the samples. Our study showed that IFN-γ protein levels are increased in radicular cysts, whereas IL-4 expression is stronger in samples of periapical granulomas. Further studies are necessary to elucidate the signaling pathways mediated by these cytokines and to facilitate the development of more effective periapical disease management strategies. Copyright © 2013 American Association of Endodontists. All rights reserved.

  17. Modélisation du procédé de soudage hybride Arc / Laser par une approche level set application aux toles d'aciers de fortes épaisseurs A level-set approach for the modelling of hybrid arc/laser welding process application for high thickness steel sheets joining

    Directory of Open Access Journals (Sweden)

    Desmaison Olivier

    2013-11-01

    Full Text Available Le procédé de soudage hybride Arc/Laser est une solution aux assemblages difficiles de tôles de fortes épaisseurs. Ce procédé innovant associe deux sources de chaleur : un arc électrique produit par une torche MIG et une source laser placée en amont. Ce couplage améliore le rendement du procédé, la qualité du cordon et les déformations finales. La modélisation de ce procédé par une approche Level Set permet une prédiction du développement du cordon et du champ de température associé. La simulation du soudage multi-passes d'une nuance d'acier 18MnNiMo5 est présentée ici et les résultats sont comparés aux observations expérimentales. The hybrid arc/laser welding process has been developed in order to overcome the difficulties encountered for joining high thickness steel sheets. This innovative process gathers two heat sources: an arc source developed by a MIG torch and a pre-located laser source. This coupling improves the efficiency of the process, the weld bead quality and the final deformations. The Level-Set approach for the modelling of this process enables the prediction of the weld bead development and the temperature field evolution. The simulation of the multi-passes welding of a 18MnNiMo5 steel grade is detailed and the results are compared to the experimental observations.

  18. Th1/Th2 cytokine expression in diabetic retinopathy.

    Science.gov (United States)

    Cao, Y L; Zhang, F Q; Hao, F Q

    2016-07-15

    Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients with type 2 DM (T2DM group) without DR, and 30 cases of T2DM patients with DR (DR group). Real-time PCR was used to measure mRNA expression of IL-2 and TNF-α, secreted from Th1 cells, and of IL-4 and IL-10, secreted from Th2 cells. We used ELISA to detect cytokine expression in serum to analyze the correlation between Th1 and Th2 cytokines. IL-2 and TNF-αmRNA and protein expression levels in the T2DM and DR groups were significantly higher than in the normal control group (P 0.05). IL-2 and TNF-αwere negatively correlated with IL-4 and IL-10 in the DR group, respectively. We found that Th1 cytokine secretion was higher and Th2 cytokines secretion was lower during DR, leading to a Th1/ Th2 imbalance, suggesting that Th1/Th2 imbalance is a side effect for DR occurrence and development.

  19. A Lightweight Intelligent Virtual Cinematography System for Machinima Production

    Science.gov (United States)

    2007-01-01

    portmanteau of machine and cinema , machinima refers to the innovation of leveraging video game technology to greatly ease the creation of computer...selecting camera angles to capture the action of an a priori unknown script as aesthetically appropriate cinema . There are a number of challenges therein...Proc. of the 4th International Conf. on Autonomous Agents. Young, R.M. and Riedl, M.O. 2003. Towards an Architecture for Intelligent Control of Narrative in Interactive Virtual Worlds. In Proc. of IUI 2003.

  20. Nuclear structure of $^{229}$Th

    CERN Document Server

    Ruchowska, E; Zylicz, J; Mach, H; Kvasil, J; Algora, A; Amzal, N; Bäck, T; García-Borge, M J; Boutami, R; Butler, P A; Cederkäll, J; Cederwall, Bo; Fogelberg, B; Fraile-Prieto, L M; Fynbo, H O U; Hagebø, E; Hoff, P; Gausemel, H; Jungclaus, A; Kaczarowski, R; Kérek, A; Kurcewicz, W; Lagergren, K; Nacher, E; Rubio, B; Syntfeld, A; Tengblad, O; Wasilewski, A A

    2006-01-01

    Lifetimes of excited states in $^{229}$Th, populated in the $\\beta$-decay of $^{229}$Ac, have been measured using the advanced time-delayed $\\beta\\gamma\\gamma$(t)-method. Half-lives of 14 states have been determined including 11 of them for the first time. Twenty-seven new $\\gamma$-lines have been introduced into the $\\beta$-decay scheme of $^{229}$Ac based on results of $\\gamma\\gamma$-coincidence measurements. Reduced transition probabilities have been determined for more than 70 $\\gamma$-transitions in $^{229}$Th. Average ∣D$_{0}$∣ values of 0.029(1), 0.077(3) and 0.024(5) $e$ fm have been deduced for the lowest K$^{\\pi}$=1/2$^{\\pm}$ , 3/2$^{\\pm}$ and 5/2$^{\\pm}$ parity partner bands, respectively. Excited states in $^{229}$Th and experimental transition rates have been interpreted within the quasiparticle-plus-phonon model. The half-life of the 3.5 eV , 3/2$^{+}$ isomeric state is predicted to be about 10 h. Potential energy surfaces on the ($\\beta_{2}\\,,\\,\\beta_{3}$) plane for the lowest single quasi...

  1. Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation

    Directory of Open Access Journals (Sweden)

    Leonor Rodríguez

    2013-02-01

    Full Text Available Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression levels of IL-12, IL-18 and IL-21, molecules that induce the differentiation of T cells related to the immunological cellular response (Th1 response and the production of cytokines related to the immunological cellular response (Th1 cytokines. We found that the expression levels of IL-12, IL-18 and IL-21 were significantly diminished in malnourished children compared to well-nourished children and were coincident with lower plasmatic levels of IL-2 and IFN-γ (Th1 cytokines. In this study, we show for the first time that the gene expression and intracellular production of cytokines responsible for Th1 cell differentiation (IL-12, IL-18 and IL-21 are diminished in malnourished children. As expected, this finding was related to lower plasmatic levels of IL-2 and IFN-γ. The decreased expression of Th1 cytokines observed in this study may contribute to the deterioration of the immunological Type 1 (cellular response. We hypothesize that the decreased production of IL-12, IL-18 and IL-21 in malnourished children contributes to their inability to eradicate infections.

  2. Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

    Science.gov (United States)

    Basdeo, Sharee A; Cluxton, Deborah; Sulaimani, Jamal; Moran, Barry; Canavan, Mary; Orr, Carl; Veale, Douglas J; Fearon, Ursula; Fletcher, Jean M

    2017-03-15

    Th17 cells are an important therapeutic target in autoimmunity. However, it is known that Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation. Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in terms of their function and regulation, and whether they have a pathogenic role in autoimmunity. We compared the phenotypic and functional features of human Th17, Th1, and ex-Th17 cell populations. Our data showed that despite their loss of IL-17 expression, ex-Th17 cells were more polyfunctional in terms of cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proinflammatory cytokines. The proliferative brake on Th17 cells appeared to be lifted because ex-Th17 cells proliferated more than Th17 cells after stimulation. In contrast with Th1 and Th17 cells, ex-Th17 cells were highly resistant to suppression of proliferation and cytokines by regulatory T cells. Finally, we showed that ex-Th17 cells accumulated in the joints of rheumatoid arthritis patients. Taken together, these data indicate that human ex-Th17 cells are functionally distinct from Th1 and Th17 cells, and suggest that they may play a pathogenic role at sites of autoimmunity, such as the rheumatoid arthritis joint where they accumulate. These findings have implications for therapeutic strategies that target IL-17, because these may not inhibit pathogenic ex-Th17 cells. Copyright © 2017 by The American Association of Immunologists, Inc.

  3. The chapter of S. Lorenzo in Genoa. Institutional dynamics and social relations (10th-12th Centuries

    Directory of Open Access Journals (Sweden)

    Luca Filangieri

    2006-06-01

    Full Text Available The subject matter of this paper is the Genoese canonical community from the first evidence related to the presence of a nucleus of religious communal life within the cathedral church (mid-10th century up to the definitive assertion ‒ in what becomes a communal and archidiocesan context ‒ of the institution thereon referred to as Capitulum. The discussion will be articulated within a framework which defines the community’s relationship with the bishop, the hierarchy within the community itself, its landed and immovable assets, and its peculiar identity in relation to the commune and the cives, in an effort to illustrate the dynamics that typify the cathedral chapter’s first three centuries of institutional life.

  4. Effect of sintering atmosphere on the hardness of ThO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Baena, Angela; Cardinaels, Thomas [Belgian Nuclear Research Centre (SCK-CEN), Institute for Nuclear Materials Science, Fuel Materials Group, Boeretang 200, B-2400, Mol (Belgium); KU Leuven, Department of Chemistry, Celestijnenlaan 200F, P.O. Box 2404, B-3001, Heverlee (Belgium); Van Eyken, Jelle; Puzzolante, Jean Louis [Belgian Nuclear Research Centre (SCK-CEN), Institute for Nuclear Materials Science, Fuel Materials Group, Boeretang 200, B-2400, Mol (Belgium); Binnemans, Koen [KU Leuven, Department of Chemistry, Celestijnenlaan 200F, P.O. Box 2404, B-3001, Heverlee (Belgium); Verwerft, Marc, E-mail: marc.verwerft@sckcen.be [Belgian Nuclear Research Centre (SCK-CEN), Institute for Nuclear Materials Science, Fuel Materials Group, Boeretang 200, B-2400, Mol (Belgium)

    2016-08-15

    The hardness and toughness of ThO{sub 2} sintered under reducing and oxidizing conditions has been investigated and, quite unexpectedly, a significant difference in hardness was observed for the entire range of porosities studied. Reducing conditions systematically yielded higher hardness values than oxidizing conditions. Extrapolated to zero porosity, the hardness for ThO{sub 2} is H{sub 0} = 10.5 ± 0.3 GPa for oxidizing conditions and H{sub 0} = 12.4 ± 0.7 GPa for reducing conditions. Toughness values have been derived from Vickers indentations; differences in toughness were insignificant and only a single value is proposed: K{sub IC} = 0.97 ± 0.12 MPa √m. The difference in hardness is attributed to the presence of point defects, also acting as color centers and causing grey coloration of ThO{sub 2} sintered under reducing conditions. Furthermore, and of interest for nuclear fuel production, is the finding that ThO{sub 2} sintered under reducing conditions is significantly easier to grind compared to material sintered under oxidizing conditions. - Highlights: • Reducing sintering conditions increase the hardness of polycrystalline ThO{sub 2}. • Systematic series of hardness versus porosity of ThO{sub 2} were obtained. • Reducing sintering conditions improve grinding of ThO{sub 2}.

  5. Concentration of 232Th, 230Th and 228Th in various tissues of Japanese subjects

    International Nuclear Information System (INIS)

    Takizawa, Y.; Qingmei, H.; Hisamatsu, S.; Abe, T.

    1997-01-01

    The concentration of 232 Th, 230 Th and 228 Th in various human tissues of Japanese subjects obtained at autopsies are reported. The tissue samples were weighed, spiked with 234 Th tracer and ashed by acid. The solution was dried on a hot-plate. Separation of thorium radionuclides was accomplished through cation-exchange resin chromatography and electrodeposition. The concentrations of thorium isotopes were measured by α-spectrometry. Thorium-232 and 230 Th concentrations were found to be highest in lung, followed by bone. The maximum concentration of 228 Th was in bone. The lowest concentrations of thorium isotopes were in muscle. (author)

  6. Emissions intensity targeting: From China's 12th Five Year Plan to its Copenhagen commitment

    International Nuclear Information System (INIS)

    Lu, Yingying; Stegman, Alison; Cai, Yiyong

    2013-01-01

    China is currently the world's largest single source of fossil fuel related CO 2 emissions. In response to pressure from the international community, and in recognition of its role in global climate change mitigation, the Chinese government has announced a series of climate policy commitments, in both the Copenhagen Accord and its domestic 12th 5 Year Plan, to gradually reduce emissions intensity by 2020. Emissions intensity reduction commitments differ significantly from emission level reduction commitments that are commonly adopted by developed economies. In this paper, we investigate the economic implications of China's recent commitments to reduce emissions intensity, and highlight the complexities involved in modelling intensity targets under uncertainty. Using G-Cubed, an intertemporal, computable general equilibrium model of the world economy, we show that China's emissions intensity targets could be achieved with a range of low and high growth emissions level trajectories corresponding to low and high growth GDP scenarios, which lead to different welfare consequences. - Highlights: • We investigate the economic implication of China's recent climate commitments. • We address the complexity of modelling reduction in emissions intensity. • The 2015 target gives China more flexibility towards its 2020 target. • The policy restriction is eased in high growth periods. • In low growth periods an intensity target places a further restriction on the economy

  7. Proceedings of the 8th topical meeting on nuclear code development

    International Nuclear Information System (INIS)

    1993-03-01

    The 8th Topical Meeting on Nuclear Code Development, organized by Committee on Reactor Physics and Nuclear Codes Committee of Japan Atomic Energy Research Institute (JAERI), was held at Tokai Research Establishment of JAERI, on 11th and 12th of November, 1992. In the meeting, 14 papers were presented on the topics of (1) the next generation nuclear reactor design system and (2) advances of the nuclear fuel reprocessing safety analysis codes. These papers are compiled in this proceedings. (author)

  8. Moving-Bed Process for Residue Hydrotreating Procédé à lit mobile pour l'hydrotraitement des résidus

    Directory of Open Access Journals (Sweden)

    Euzen J. P.

    2006-11-01

    : lits fixes utilisés avec des réacteurs permutables, lits fluidisés ou lits mobiles à écoulement en cocourant ou en contre-courant de la charge et du catalyseur. La comparaison théorique des performances des différentes configurations a été réalisée grâce à une simulation détaillée du comportement, sur une longue période, de chacun de ces lits catalytiques. Quelques hypothèses sont naturellement nécessaires dans les modèles, concernant par exemple les écoulements des fluides et des particules solides. Le problème n'en reste pas moins complexe car les effets hydrodynamiques, cinétiques, de désactivation du catalyseur ou enfin les effets thermiques se produisent tous simultanément, dans les particules mêmes ou dans la totalité du lit de catalyseur. Des données d'unités pilotes diverses permettent d'établir la partie cinétique des modèles. Cette comparaison fait apparaître un net avantage en faveur du lit mobile avec écoulement à contre courant des fluides et du catalyseur grâce à l'utilisation optimum du potentiel du catalyseur. C'est pourquoi une série d'expériences a été faite sur des maquettes de différentes tailles conçues pour simuler les lits mobiles à contre-courant. Il était nécessaire d'effectuer ces expériences pour prouver que ce procédé est réalisable, pour spécifier les relations existant entre les vitesses superficielles des gaz et des liquides, les propriétés des particules et des fluides, les régimes hydrodynamiques et pour élaborer des règles d'extrapolation des données. Le but principal est d'assurer une distribution uniforme des deux fluides sur la totalité du lit de catalyseur tout en maintenant une progression régulière des particules solides pendant le soutirage séquentiel. C'est pourquoi le mouvement du solide et la répartition des temps de séjour des particules de catalyseur ont été particulièrement observés. A cette fin, une nouvelle technique a été mise au point pour mesurer la

  9. The neo-epitope specific PRO-C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters

    DEFF Research Database (Denmark)

    Nielsen, Mette J; Nedergaard, Anders F; Sun, Shu

    2013-01-01

    AIM: The present study describes the assessment of true formation of type III collagen in different pathologies using a neo-epitope specific competitive Enzyme-linked immunosorbent assay (ELISA) towards the N-terminal propeptide of type III collagen (PRO-C3). METHODS: The monoclonal antibody...... was raised against the N-protease mediated cleavage site of the N-terminal propeptide of type III collagen and a competitive ELISA was developed using the selected antibody. The assay was evaluated in relation to neo-epitope specificity, technical performance, and as a marker for liver fibrosis and muscle...... mass using the rat carbon tetrachloride (CCl4) model and a study of immobilization induced muscle loss in humans, respectively. RESULTS: The ELISA was neo-epitope specific, technically stable and can be assessed in serum and plasma samples. In the CCl4 liver fibrosis model it was observed that serum...

  10. Structural and magnetic order of ThMn12-type rare earth-iron-aluminium intermetallics studied by neutron diffraction

    International Nuclear Information System (INIS)

    Schaefer, W.; Halevy, I.; Gal, J.

    2000-01-01

    neutron powder diffraction data of ThMn 12 -type compounds RFe 4 Al 8 , RFe 5 Al 7 , and RFe 6 Al 6 (R = heavy rare earth) are compared to work out the structural variations and the different magnetic properties of these ternary intermetallics as a function of increasing iron concentrations. The variations of unit cell metric, of atomic coordinations and of interatomic distances are discussed. A magnetic phase diagram is presented showing the increase of the magnetic ordering temperatures from 120 K to 340 K and the change of the magnetic order from two separate magnetic phase transitions of rare earth and iron sublattices to one common ferrimagnetic transition of both sublattices, when changing the ratio of Fe/Al atoms from 4/8 to 6/6, respectively. Long range order is hampered by frozen spins. Magnetically ordered rare earth and iron moments are given. (orig.)

  11. Nonlinear Acoustics: Periodic Waveguide, Scattering of Sound by Sound, Three-Layer Fluid, Finite Amplitude Sound in a Medium Having a Distribution of Relaxation Processes, and Production of an Isolated Negative Pulse in Water

    Science.gov (United States)

    1993-06-03

    propagation and shape of the waveform," Conference on Lithotripsy (Extra-Corporeal Shock Wave Applications - Technical and Clinical Problems), Univer- sity of...Blackstock, "Physical aspects of lithotripsy ," Paper GG1, 115th Meeting, Acoustical Society of America, Seattle, 16-20 May 1988. ABSTRACT: J. Acoust...Am. 90, 2244(A) (1991). kAlso supported in part by Grant NAG-1-1204 and University of Southampton , Eng- land. 49 1992 ONR Contract Code 1109 JS 1. F

  12. Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation.

    Science.gov (United States)

    Rø, A D B; Simpson, M R; Rø, T B; Storrø, O; Johnsen, R; Videm, V; Øien, T

    2017-08-01

    In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD. A total of 415 pregnant women were randomized to ingest a combination of Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. lactis Bb-12 (Bb-12) and Lactobacillus acidophilus La-5 (La-5) or placebo, and their offspring were assessed for AD during the first 2 years of life. Peripheral blood collected at 3 months of age was analysed for regulatory T cells (n=140) and Th subsets (n=77) including Th1, Th2, Th9, Th17 and Th22. The proportion of Th22 cells was reduced in children in the probiotic group compared to the placebo group (median 0.038% vs 0.064%, P=.009). The difference between the probiotic and placebo groups was also observed in the children who did not develop AD during the 2-year follow-up. The proportion of Th22 cells was increased in children who developed AD compared to the children who did not develop AD (0.090% vs 0.044%, Pprobiotics was partially mediated through the reduction in Th22 cells. Perinatal maternal probiotic supplementation with a combination of LGG, Bb-12 and La-5 reduced the proportion of Th22 cells in 3-month-old children. This may partially explain the preventive effect of probiotics on AD. © 2017 John Wiley & Sons Ltd.

  13. PREFACE: 12th European Workshop on Advanced Control and Diagnosis (ACD 2015)

    Science.gov (United States)

    Straka, Ondřej; Punčochář, Ivo; Duník, Jindřich

    2015-11-01

    The 12th European Workshop on Advanced Control and Diagnosis (ACD 2015) took place at the Research Centre NTIS - New Technologies for the Information Society, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czech Republic, on November 19 - 20, 2015. The annual European Workshop on Advanced Control and Diagnosis has been organized since 2003 by Control Engineering departments of several European universities in Germany, France, the UK, Poland, Italy, Hungary, and Denmark to bring together senior and junior academics and engineers from diverse fields of automatic control, fault detection, and signal processing. The workshop provides an opportunity for researchers and developers to present their recent theoretical developments, practical applications, or even open problems. It also offers a great opportunity for industrial partners to express their needs and priorities and to review the current activities in the fields. A total of 74 papers have been submitted for ACD 2015. Based on the peer reviews 48 papers were accepted for the oral presentation and 10 papers for the poster presentation. The accepted papers covered areas of control theory and applications, identification, estimation, signal processing, and fault detection. In addition, four excellent plenary lectures were delivered by Prof. Fredrik Gustafsson (Automotive Sensor Mining for Tire Pressure Monitoring), Prof. Vladimír Havlena (Advanced Process Control for Energy Efficiency), Prof. Silvio Simani (Advanced Issues on Wind Turbine Modelling and Control), and Prof. Robert Babuška (Learning Control in Robotics). The ACD 2015 was for the first time in the workshop history co-sponsored by the International Federation of Automatic Control (IFAC). On behalf of the ACD 2015 organising committee, we would like to thank all those who prepared and submitted papers, participated in the peer review process, supported, and attended the workshop.

  14. Thermodynamic studies of thorium phosphate diphosphate and phase investigations of Th-P-O and Th-P-H2O systems

    International Nuclear Information System (INIS)

    Rawat, Deepak; Dash, Smruti; Joshi, A.R.

    2014-01-01

    Highlights: • Δ f H m o (298.15K)andC p,m o (T) of Th 2 P 3 O 13 H 3 (cr), Th 2 P 3 O 12 H(cr), α-Th 4 P 6 O 23 (cr) and β-Th 4 P 6 O 23 (cr) were measured. • Thermo-chemical reaction scheme was formulated to calculate the standard molar enthalpy of formation of β-Th 4 (PO 4 ) 4 P 2 O 7 (cr). • The thermodynamic functions of the compounds present in Th-P-O and Th-P-H 2 O systems have been estimated. • The Gibbs phase diagram and predominant area diagrams for Th-P-O system have been calculated. • E H –pH diagram of Th-P-H 2 O system has been computed to determine stability of β-Th 4 P 6 O 23 (cr) in the ground water. - Abstract: The standard molar enthalpy of formation of thorium phosphate diphosphate, β-Th 4 (PO 4 ) 4 P 2 O 7 (cr) has been determined using an isoperibol solution calorimeter, a differential scanning calorimeter and phase transition data of high temperature calorimeter. The enthalpy of precipitation of thorium phosphate-hydrogenphosphate hydrate, Th 2 (PO 4 ) 2 (HPO 4 )·H 2 O(cr), was measured at 298.15 K using an isoperibol solution calorimeter. Heat capacities of α-Th 4 (PO 4 ) 4 P 2 O 7 (cr) and β-Th 4 (PO 4 ) 4 P 2 O 7 (cr) were measured using a Differential Scanning Calorimeter. Combining these experimental data, and other auxiliary data from the literature, thermo-chemical reaction scheme was devised to calculate the standard molar enthalpy of formation of β-Th 4 (PO 4 ) 4 P 2 O 7 (cr) to be {−10565.5 ± 13.6} kJ mol −1 . The thermodynamic functions for β-Th 4 (PO 4 ) 4 P 2 O 7 (cr) have been computed using Δ f H m o (298.15K),C p,m o (T) and literature data. The Gibbs phase diagram and predominant area diagrams for Th-P-O system have been computed using the thermodynamic information of the various phase present in Th-P, P-O and ThO 2 -P 2 O 5 systems. E H –pH diagram of Th-P-H 2 O system has been computed to determine stability of Th 4 P 6 O 23 (cr) in ground water

  15. Study on the correlationship between serum levels of sex hormones and Th1/Th2 cytokines in male patients with graves' disease

    International Nuclear Information System (INIS)

    Liu Li; Su Shengou; Zhang Xuekun; Wang Hongfen

    2009-01-01

    Objective: To explore the effect of sex hormones on the balance of Th1/Th2 in male patients with GD through investigation of changes of serum levels of sex hormones and cytokines (IFN-γ and IL-4) after treatment. Methods: Serum levels of E 2 , testosterone, FSH, LH (with RIA) and IFN-γ, IL-4 (with ELISA) were determined in 42 male patients with Graves' disease (both before and after 12 weeks of successful antithyroid therapy) and 40 controls. Results: The levels of E 2 , T, LH, FSH in the patients before treatment were significantly higher than those in the controls (P 2 was an independent fator affecting the levels of IL-4, and showed positive correlationship. The level of T was an independent factor affecting the levels of IFN-γ, also showed positive correlationship. The levels of IL-4 and IFN-γ were independent factors to each other, and there was negative correlationship between them. Conclusion: There were changes in levels of sex hormones and imbalance of Th1/Th2 in male patients with Graves' disease. The sex hormones might have some effect on Th1/Th2 balance in male patients with GD. (authors)

  16. The Identity of Patients in 12th Century Medical Text in Persian: a Sociolinguistic Perspective

    Directory of Open Access Journals (Sweden)

    Manizheh Abdollahi

    2013-05-01

    Full Text Available This study investigates linguistic expressions featuring the patient in a medical textbook written in the 12th century in Persian. At this time, medical practice is noticed to be more scientific than those written years before or even many centuries after because, keeping a distance from superstitious views, the practice follows the scientific procedures of the day. The present study adopts a sociolinguistics perspective to examine the social status of the patient in the text. The textbook – “Khofi Alayee” – was chosen to be examined mainly because it was considered as a scientific book written for public  use; also it was published as  a kind of pocket book for people to use while on trip or, more importantly, when the doctors were in emergency situations. This text, like other medical texts, is expected to be written impartially, but this is not usually the case. The result of the study showed that the patient was primarily viewed as an object with no social status considered for revered citizen. On the other hand, in occasions when the patient was treated as a person, he represented a male belonging to the middle or higher classes of the society.

  17. Proceedings of the 4th Australian experimental high energy physics meeting and workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The 4th Annual Meeting of the Australian High Energy Physics Consortium was held at ANSTO on the 11th and 12th of December, with a workshop on software development and applications held at the University f Sydney on the 13th. A wide range of talks on the progress of NOMAD and ATLAS experiments and related research were presented, plus talks on heavy ion physics which is also carried out in collaboration with CERN. Extended abstracts of the presentations are included in this volume.

  18. Proceedings of the 4th Australian experimental high energy physics meeting and workshop

    International Nuclear Information System (INIS)

    1995-01-01

    The 4th Annual Meeting of the Australian High Energy Physics Consortium was held at ANSTO on the 11th and 12th of December, with a workshop on software development and applications held at the University f Sydney on the 13th. A wide range of talks on the progress of NOMAD and ATLAS experiments and related research were presented, plus talks on heavy ion physics which is also carried out in collaboration with CERN. Extended abstracts of the presentations are included in this volume

  19. Proceedings of the 4th Australian experimental high energy physics meeting and workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The 4th Annual Meeting of the Australian High Energy Physics Consortium was held at ANSTO on the 11th and 12th of December, with a workshop on software development and applications held at the University f Sydney on the 13th. A wide range of talks on the progress of NOMAD and ATLAS experiments and related research were presented, plus talks on heavy ion physics which is also carried out in collaboration with CERN. Extended abstracts of the presentations are included in this volume.

  20. Discrimination of DPRK M5.1 February 12th, 2013 Earthquake as Nuclear Test Using Analysis of Magnitude, Rupture Duration and Ratio of Seismic Energy and Moment

    Science.gov (United States)

    Salomo Sianipar, Dimas; Subakti, Hendri; Pribadi, Sugeng

    2015-04-01

    On February 12th, 2013 morning at 02:57 UTC, there had been an earthquake with its epicenter in the region of North Korea precisely around Sungjibaegam Mountains. Monitoring stations of the Preparatory Commission for the Comprehensive Nuclear Test-Ban Treaty Organization (CTBTO) and some other seismic network detected this shallow seismic event. Analyzing seismograms recorded after this event can discriminate between a natural earthquake or an explosion. Zhao et. al. (2014) have been successfully discriminate this seismic event of North Korea nuclear test 2013 from ordinary earthquakes based on network P/S spectral ratios using broadband regional seismic data recorded in China, South Korea and Japan. The P/S-type spectral ratios were powerful discriminants to separate explosions from earthquake (Zhao et. al., 2014). Pribadi et. al. (2014) have characterized 27 earthquake-generated tsunamis (tsunamigenic earthquake or tsunami earthquake) from 1991 to 2012 in Indonesia using W-phase inversion analysis, the ratio between the seismic energy (E) and the seismic moment (Mo), the moment magnitude (Mw), the rupture duration (To) and the distance of the hypocenter to the trench. Some of this method was also used by us to characterize the nuclear test earthquake. We discriminate this DPRK M5.1 February 12th, 2013 earthquake from a natural earthquake using analysis magnitude mb, ms and mw, ratio of seismic energy and moment and rupture duration. We used the waveform data of the seismicity on the scope region in radius 5 degrees from the DPRK M5.1 February 12th, 2013 epicenter 41.29, 129.07 (Zhang and Wen, 2013) from 2006 to 2014 with magnitude M ≥ 4.0. We conclude that this earthquake was a shallow seismic event with explosion characteristics and can be discriminate from a natural or tectonic earthquake. Keywords: North Korean nuclear test, magnitude mb, ms, mw, ratio between seismic energy and moment, ruptures duration

  1. Current status and future trends of SO2 and NOx pollution during the 12th FYP period in Guiyang city of China

    Science.gov (United States)

    Tian, Hezhong; Qiu, Peipei; Cheng, Ke; Gao, Jiajia; Lu, Long; Liu, Kaiyun; Liu, Xingang

    2013-04-01

    In order to investigate the future trends of SO2 and NOx pollution in Guiyang city of China, the MM5/CALMET/CALPUFF modeling system is applied to assess the effects of air pollution improvement that would result from reduction targets for SO2 and NOx emissions during the 12th Five-Year Plan (2011-2015). Three scenarios are established for the objective year 2015 based on the reference emissions in base year 2010. Scenario analysis and modeling results show that emissions are projected to increase by 26.5% for SO2 and 138.0% for NOx in 2015 Business-As-Usual (BAU) relative to base year 2010, respectively, which will lead to a substantial worsening tendency of SO2 and NOx pollution. In comparison, both the 2015 Policy Reduction (PR) and 2015 Intensive Policy Reduction (IPR) scenarios would contribute to improve the urban air quality. Under 2015 PR scenario, the maximum annual average concentration of SO2 and NOx will reduce by 54.9% and 31.7%, respectively, relative to the year 2010, with only 2.1% of all individual gridded receptors exceed the national air quality standard limits; while the maximum annual average concentrations of SO2 and NOx can reduce further under 2015 IPR scenario and comply well with standards limits. In view of the technical feasibility and cost-effectiveness, the emission reduction targets set in the 2015 PR scenario are regarded as more reasonable in order to further improve the air quality in Guiyang during the 12th FYP period and a series of comprehensive countermeasures should be effectively implemented.

  2. The World of Microbes 2002: scientific advances and challenges--impressions and highlights from the 12th Congress of Virology.

    Science.gov (United States)

    Becker, Yechiel

    2002-12-01

    Thousands of scientists participated in the World of Microbes Congress, which was organized by the International Union of the Microbiological Societies (IUMS) and took place in the Palais de Congres in Paris, France from 27 July to 1 August 2002. The attendees were members of the IUMS divisions of Bacteriology and Applied Microbiology, Mycology, and Virology. In addition to the symposia that were organized by each division, joined plenary symposia were held, which encompassed subjects of common interest to all microbiologists. The activities at the 12th Congress of Virology's plenary lectures, symposia, and poster sessions were organized to accommodate the presentation of over 1500 presentations. These brief comments are aimed to provide a sample of only a few presentations that dealt with subjects of emerging and re-emerging virus diseases, which are of general interest.

  3. IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

    Science.gov (United States)

    Mitchell, Ruth E; Hassan, Masriana; Burton, Bronwen R; Britton, Graham; Hill, Elaine V; Verhagen, Johan; Wraith, David C

    2017-09-12

    IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4 + T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet + cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 cultures. These data demonstrate that IL-4 contributes to IL-10 production and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the cross-regulation of Th1 and Th2 cells. These findings are important in the context of Th1 driven diseases since they reveal how the Th1 phenotype and function can be modulated by IL-4.

  4. Comparison of Values in 5th, 6th, 7th and 8th Grade Primary Education Music Class Students'? Workbooks According to Rokeach?s and Akbas's Value Classifications

    Science.gov (United States)

    Çakirer, H. Serdar

    2014-01-01

    The aim of the present study is to compare the values in the songs of 5th, 6th, 7th and 8th grade primary education music classes students? workbooks according to the value categorizations proposed by Rockeach and Akbas and which values among the categories mentioned are taught to the students in the 5th, 6th, 7th and 8th grade primary education…

  5. Nonlinear Acoustics: Periodic Waveguide, Finite-Amplitude Propagation in a Medium Having a Distribution of Relaxation Processes, and Production of an Isolated Negative Pulse in Water

    Science.gov (United States)

    1993-08-24

    T. Blackstock, "Shock wave propagation and shape of the waveform," Conference on Lithotripsy (Extra-Corporeal Shock Wave Applications - Technical and...83, S5 (1988). 0574 0 b4 . D. T. Blackstock, "Physical aspects of lithotripsy ," Paper GG1, 115th Meeting, Acoustical Society of America, Seattle, 16...1991). kAlso supported in part by Grant NAG-1-1204 and University of Southampton , Eng- land. 23 1992 ONR Contract Code 1109 0 𔃻. James A. Ten Cate

  6. Improvement of the NSSS T/H Module ARTS for Enhancing the Simulation Fidelity of YGN no 1/2 Simulator

    International Nuclear Information System (INIS)

    Seo, In Yong; Lee, Myung Soo; Lee, Yong Kwan; Suh, Jae Seung; Jeun, Gyoo Dong

    2006-01-01

    KEPRI(Korea Electric Power Research Institute) and KAERI(Korea Atomic Energy Research Institute) developed a NSSS (Nuclear Steam Supply System) T/H (Thermal-Hydraulic) module (named ARTS) based on the best-estimate code RETRAN-3D for the KNPEC-2 full-scope simulator in 2001. Although ARTS can simulate the most transients in real-time, and its robustness is ensured, real-time calculation and robustness can fail for large break loss-of-coolant accident (LBLOCA) and long term, two-phase transients. In order to improve its robustness, ARTS equipped with the backup calculation module to be used whenever a regular ARTS module fails to calculate. When the symptom for the failure of T/H module is detected, the main ARTS module is replaced with the backup module for the calculation of primary and secondary reactor system although most failures of ARTS occur in the calculation of the primary system especially for LBLOCA simulation. The sudden transition from the main ARTS module to the backup module can exhibit the discontinuity of simulation of secondary system on rare occasions. To mitigate the simulation discontinuity, we have improved the backup module of ARTS. The performance of a new approach has been illustrated by the non-integrated standalone test. The improved ARTS module will be incorporated into YGN no. 1/2 simulator and evaluated its performance in the real simulator environment. This paper presents the brief description of a new backup calculation strategy and the simulation results of LOCA to evaluate the performance of a new backup strategy in standalone test environment

  7. 12th Quadrennial Congress of the International Association for Radiation Research incorporating the 50th Annual Meeting of Radiation Research Society, RANZCR Radiation Oncology Annual Scientific Meeting and AINSE Radiation Science Conference

    International Nuclear Information System (INIS)

    2003-01-01

    The 12th International Congress of Radiation Research (ICRR2003), for the first time held in the Southern Hemisphere under the auspices of the International Association of Radiation Research (IARR). The Australian affiliate of IARR is the Australian Institute of Nuclear Science and Engineering (AINSE). As with recent Congresses, the annual scientific meeting of the Radiation Research Society will be incorporated into the program. The Congress will be further enhanced by the integration of the annual scientific meeting of the Faculty of Radiation Oncology of the Royal Australian and New Zealand College of Radiologists, and the AINSE Radiation Science Conference. An exciting programme was presented with the main threads being radiation oncology, radiation biology, radiation chemistry/physics, radiation protection and the environment. Items in INIS scope have been separately indexed

  8. Chaotic systems in complex phase space

    Indian Academy of Sciences (India)

    figure 1, a qualitative change in the complex behaviour is quite evident in ..... [19] S Fishman, Quantum Localization in Quantum Chaos, Proc. of the International ... of the 44th Scottish Universities Summer School in Physics, Stirling, August ...

  9. Discharge estimation in compound channels with fixed and mobile ...

    Indian Academy of Sciences (India)

    Early work by Myers & Elsawy (1975), Myers (1978), Wormleaton, et al (1982), ... that the local boundary shear stress, τb, and the depth-averaged velocity, Ud, are ...... Proc. of 7th International Symposium on River Sedimentation, Hong Kong :.

  10. The PDL1-PD1 Axis Converts Human Th1 Cells Into Regulatory T Cells

    Science.gov (United States)

    Amarnath, Shoba; Mangus, Courtney W.; Wang, James C.M.; Wei, Fang; He, Alice; Kapoor, Veena; Foley, Jason E.; Massey, Paul R.; Felizardo, Tania C.; Riley, James L.; Levine, Bruce L.; June, Carl H.; Medin, Jeffrey A.; Fowler, Daniel H.

    2011-01-01

    Immune surveillance by T helper type 1 (Th1) cells is critical for the host response to tumors and infection, but also contributes to autoimmunity and graft-versus-host disease (GvHD) after transplantation. The inhibitory molecule programmed death ligand-1 (PDL1) has been shown to anergize human Th1 cells, but other mechanisms of PDL1-mediated Th1 inhibition such as the conversion of Th1 cells to a regulatory phenotype have not been well characterized. We hypothesized that PDL1 may cause Th1 cells to manifest differentiation plasticity. Conventional T cells or irradiated K562 myeloid tumor cells overexpressing PDL1 converted TBET+ Th1 cells into FOXP3+ regulatory T cells (TREGS) in vivo, thereby preventing human-into-mouse xenogeneic GvHD (xGvHD). Either blocking PD1 expression on Th1 cells by siRNA targeting or abrogation of PD1 signaling by SHP1/2 pharmacologic inhibition stabilized Th1 cell differentiation during PDL1 challenge and restored the capacity of Th1 cells to mediate lethal xGVHD. PD1 signaling therefore induces human Th1 cells to manifest in vivo plasticity, resulting in a TREG phenotype that severely impairs cell-mediated immunity. Converting human Th1 cells to a regulatory phenotype with PD1 signaling provides a potential way to block GvHD after transplantation. Moreover, because this conversion can be prevented by blocking PD1 expression or pharmacologically inhibiting SHP1/2, this pathway provides a new therapeutic direction for enhancing T cell immunity to cancer and infection. PMID:22133721

  11. 6th International Microbeam Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Dr Kevin M. Prise

    2004-01-01

    The extended abstracts which are submitted here present a summary of the proceedings of the 6th International Workshop/12th LH Gray Workshop: Microbeam Probes of Cellular Radiation Response, held at St. Catherine's College, University of Oxford, UK on March, 29th-31st, 2003. In 1993 the 4th LH Gray Workshop entitled ''Microbeam Probes of Cellular Radiation Response'' was held at the Gray Cancer Institute in Northwood. This was organized by Prof BD Michael, Dr M. Folkard and Dr KM Prise and brought together 40 participants interested in developing and applying new microbeam technology to problems in radiation biology (1). The workshop was an undoubted success and has spawned a series of subsequent workshops every two years. In the past, these workshops have been highly successful in bringing together groups interested in developing and applying micro-irradiation techniques to the study of cell and tissue damage by ionizing radiations. Following the first microbeam workshop, there has been a rapid growth in the number of centres developing radiobiology microbeams, or planning to do so and there are currently 15-20 worldwide. Much of the recent research using microbeams has used them to study low-dose effects and ''non-targeted'' responses such bystander effects, genomic instability and adaptive responses. The goal of the 6th workshop was to build on our knowledge of the development of microbeam approaches and the application to radiation biology in the future with the meeting stretching over a 3 day period. Over 80 participants reviewed the current state of radiobiology microbeam research worldwide and reported on new technological developments both in the fields of physics and biology.

  12. The utility of a 5(th) nap in multiple sleep latency test.

    Science.gov (United States)

    Muza, Rexford; Lykouras, Dimosthenis; Rees, Kate

    2016-02-01

    This is the first study that aimed to look specifically at the utility of the 5(th) nap in the multiple sleep latency test (MSLT), a test used to assist in the diagnosis of narcolepsy. Data was retrospectively collected from the Sleep Disorders Centre of a Tertiary Hospital on patients that had a 5(th) nap during their MSLT from the 08(th) November 2011 to 12(th) November 2014. Fifty-three patients had a 5(th) nap performed out of 378 MSLT studies. In 16% of cases a diagnosis of narcolepsy was given directly due to the inclusion of the 5(th) nap on the MSLT. Here a 5(th) nap allowed diagnostic criteria of mean sleep latency 2 SOREMPS to be met. In 53% of cases the mean sleep latency increased due to 5(th) nap inclusion; the mean sleep latency of the first four naps was 5.6 vs. 6.7 after inclusion of the 5(th) nap. The 5(th) nap is not often performed within the MSLT studies. Our study shows that only a few patients may benefit from a 5(th) nap opportunity which also led to increase of the mean sleep latency at the expense of extra time, cost, labour and increased patient anxiety.

  13. Biological studies in the Antarctic waters: A review

    Digital Repository Service at National Institute of Oceanography (India)

    Dhargalkar, V.K.

    stream_size 12 stream_content_type text/plain stream_name Proc_Workshop_Antarct_Stud_1990_407.pdf.txt stream_source_info Proc_Workshop_Antarct_Stud_1990_407.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  14. Development of a Semi-Autonomous Underwater Vehicle for Intervention Missions (SAUVIM Phase III-C)

    Science.gov (United States)

    2010-01-28

    James Fein from ONR, Mr. Chris Hillenbrand became the ONR Program Officer for the SAUVIM project. In 2002, Dr. David Drumheller became the new ONR...Gary McMurtry, Dr. Song K. Choi & Mr. Oliver T. Easterday Past Personnel: Mr. Yann Douyere, Mr. Alan Parsa & Mr. Max D. Cremer Objectives The

  15. Determination of Th-230 in water

    International Nuclear Information System (INIS)

    Oliveira Melo, M.A.M. de

    1990-01-01

    On of the current goals of the Radiochemistry Division of CDTN is to acquire capability in determining contaminants of high radiotoxicity in different matrixes. The method described here was developed in order to determine Th-230 in water, one of the decay products of the uranium series, belongs to the most restrictive class of radionuclides, on account of its alpha emission and half-life of 8 x 10 4 years. The method conesists of two radiochemical steps, one electrodeposition step and alpha spectrometry with the use of a surface-barrier detector. Water samples with internal Th-230 standards were analysed and the results showed good reproducibility with erros a around 10% and alfa detection efficiency of 12%. The lower detection limit is around 0,4 Bq/l. (author) [pt

  16. Relationships between Work Values, Socio-Educational and Work Experiences, and Vocational Aspirations of 6th, 9th, 10th, and 12th Graders

    Science.gov (United States)

    Wijting, Jan P.; And Others

    1977-01-01

    Using a cross-sectional design and canonical regression analysis, the differential relationships between work values and social, educational, and occupational experiences and aspirations were examined for boys and girls in grades 6, 9, 10, and 12. Support was found for predicted differences in work-values correlates across grades and between…

  17. Longitudinal Model Building Using Latent Transition Analysis: An Example Using School Bullying Data

    Directory of Open Access Journals (Sweden)

    Ji Hoon Ryoo

    2018-05-01

    Full Text Available Applications of latent transition analysis (LTA have emerged since the early 1990s, with numerous scientific findings being published in many areas, including social and behavioral sciences, education, and public health. Although LTA is effective as a statistical analytic tool for a person-centered model using longitudinal data, model building in LTA has often been subjective and confusing for applied researchers. To fill this gap in the literature, we review the components of LTA, recommend a framework of fitting LTA, and summarize what acceptable model evaluation tools should be used in practice. The proposed framework of fitting LTA consists of six steps depicted in Figure 1 from step 0 (exploring data to step 5 (fitting distal variables. We also illustrate the framework of fitting LTA with data on concerns about school bullying from a sample of 1,180 students ranging from 5th to 9th grade (mean age = 12.2 years, SD = 1.29 years at Time 1 over three semesters. We identified four groups of students with distinct patterns of bullying concerns, and found that their concerns about bullying decreased and narrowed to specific concerns about rumors, gossip, and social exclusion over time. The data and command (syntax files needed for reproducing the results using SAS PROC LCA and PROC LTA (Version 1.3.2 (2015 and Mplus 7.4 (Muthén and Muthén, 1998–2015 are provided as online supplementary materials.

  18. Isothermal equilibrium pressures of Y-Th alloy-H2 system

    International Nuclear Information System (INIS)

    Tanase, M.; Fisher, P.W.

    1985-01-01

    Isothermal equilibrium pressures of the Y 4 Th (3:2 by weight) alloy-H 2 system were measured as a function of atomic composition [H]/[Y + Th] in the temperature range 580-1160 K. The isotherms have two plateaux in the pressure range 10 -2 -10 3 Pa. The first plateau region is attributed to the formation of YH 2 , and the equilibrium pressure P in pascals was found to be log P = 12.36 - 11300/T where T is in kelvins. The second plateau is attributed to the formation of ThH 2 , and the equilibrium pressure was found to be log P = 10.66 - 6891/T. In low atomic composition region the system obeys Sieverts' law. (Auth.)

  19. Th1 and Th2 help for B cells

    DEFF Research Database (Denmark)

    Poudrier, J; Owens, T

    1995-01-01

    that IL-5 (125 U/ml) synergizes with Th1 cells to induce B cell responses to IL-2, that are maintained following T-cell removal, e.g. autonomous. Th1 help in the absence of IL-5 resulted in weak or undetectable responses following T cell removal. The mechanism of IL-5 synergy involved persistence of IL-2R...... anti-Ig did not circumvent the need for IL-5 for autonomous IL-2 responses. Consistent with the above, interaction with an IL-5-producing Th2 clone induced strong autonomous B cell responses to IL-2. Qualitative differences of Th2 help over that of Th1 may thus be attributable to their differential...

  20. In vitro Comparative Evaluation of Tensile Bond Strength of 6(th), 7(th) and 8(th) Generation Dentin Bonding Agents.

    Science.gov (United States)

    Kamble, Suresh S; Kandasamy, Baburajan; Thillaigovindan, Ranjani; Goyal, Nitin Kumar; Talukdar, Pratim; Seal, Mukut

    2015-05-01

    Newer dentin bonding agents were developed to improve the quality of composite restoration and to reduce time consumption in its application. The aim of the present study was to evaluate tensile bond strength of 6(th), 7(th) and 8(th) generation bonding agents by in vitro method. Selected 60 permanent teeth were assigned into 20 in each group (Group I: 6(th) generation bonding agent-Adper SE plus 3M ESPE, Group II: 7(th) generation bonding agent-G-Bond GC Corp Japan and Group III: 8(th) generation dentin adhesives-FuturaBond, DC, Voco, Germany). With high-speed diamond disc, coronal dentin was exposed, and selected dentin bonding agents were applied, followed by composite restoration. All samples were saved in saline for 24 h and tensile bond strength testing was done using a universal testing machine. The obtained data were tabulated and statistically analyzed using ANOVA test. The tensile bond strength readings for 6(th) generation bonding agent was 32.2465, for 7(th) generation was 31.6734, and for 8(th)-generation dentine bonding agent was 34.74431. The highest tensile bond strength was seen in 8(th) generation bonding agent compared to 6(th) and 7(th) generation bonding agents. From the present study it can be conclude that 8(th) generation dentine adhesive (Futura DC, Voco, Germany) resulted in highest tensile bond strength compared to 6(th) (Adper SE plus, 3M ESPE) and 7(th) generation (G-Bond) dentin bonding agents.

  1. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12.

    Directory of Open Access Journals (Sweden)

    Hyeon-Sook Suh

    Full Text Available The essential role of progranulin (PGRN as a neurotrophic factor has been demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes frontotemporal lobar dementia. In addition to neurons, microglia in vivo express PGRN, but little is known about the regulation of PGRN expression by microglia.In the current study, we examined the regulation of expression and function of PGRN, its proteolytic enzyme macrophage elastase (MMP-12, as well as the inhibitor of PGRN proteolysis, secretory leukocyte protease inhibitor (SLPI, in human CNS cells.Cultures of primary human microglia and astrocytes were stimulated with the TLR ligands (LPS or poly IC, Th1 cytokines (IL-1/IFNγ, or Th2 cytokines (IL-4, IL-13. Results were analyzed by Q-PCR, immunoblotting or ELISA. The roles of MMP-12 and SLPI in PGRN cleavage were also examined.Unstimulated microglia produced nanogram levels of PGRN, and PGRN release from microglia was suppressed by the TLR ligands or IL-1/IFNγ, but increased by IL-4 or IL-13. Unexpectedly, while astrocytes stimulated with proinflammatory factors released large amounts of SLPI, none were detected in microglial cultures. We also identified MMP-12 as a PGRN proteolytic enzyme, and SLPI as an inhibitor of MMP-12-induced PGRN proteolysis. Experiments employing PGRN siRNA demonstrated that microglial PGRN was involved in the cytokine and chemokine production following TLR3/4 activation, with its effect on TNFα being the most conspicuous.Our study is the first detailed examination of PGRN in human microglia. Our results establish microglia as a significant source of PGRN, and MMP-12 and SLPI as modulators of PGRN proteolysis. Negative and positive regulation of microglial PGRN release by the proinflammatory/Th1 and the Th2 stimuli, respectively, suggests a fundamentally different aspect of PGRN regulation compared to other known microglial activation products. Microglial PGRN appears to function as an endogenous

  2. Growth, feed intake and body composition of ostriches (Struthio ...

    African Journals Online (AJOL)

    the ostrich breeding flock of the Klein Karoo Agricultural. Development Centre and ... The diet was initially formulated according to poultry values. (Du Preez et al., 1984; Du ...... body weight on high or low nutrient density diets. Proc. 9th Symp.

  3. The Exponentially Embedded Family of Distributions for Effective Data Representation, Information Extraction, and Decision Making

    Science.gov (United States)

    2013-03-01

    Integration of Mul- tiple Tripolar Concentric Ring Electrodes Improves Pentylenetetrazole- induced Seizure Onset Detection in Rats," in Proc. 34th Annual...Sensor Integration for Seizure Onset Detection in Human Patients Comparing Conventional Disc versus Novel Tripolar Concentric Ring Electrodes

  4. A comparison between female lambs of the Dorper and two ...

    African Journals Online (AJOL)

    Ten ewe lambs in each of the three groups were individually fed in metabolic cages and .... Regression equations and model parameters as well as the analysis of variance ..... Lessons from laboratory animal studies. Proc.6thConf. Ausl. Assoc ...

  5. Learning at a Distance. Report on the DSE Conference (West Berlin, Germany, June 2-7, 1982) in Connection with the World Conference of ICCE (12th, Vancouver, Canada, June 8-17, 1982).

    Science.gov (United States)

    German Foundation for International Development, Bonn (West Germany).

    Two international meetings on distance education are summarized in this report. The first, a preparatory seminar on "Staff Development for Distance Education," was held in Berlin to give African participants an opportunity to meet prior to attending the 12th World Conference of the International Council for Correspondence Education…

  6. EnviroAtlas - HU12_polygon

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data set is a complete digital hydrologic unit boundary layer to the Subwatershed (12-digit) 6th level for the entire United States. This data set consists of...

  7. The role of Th1 and Th17 cells in glomerulonephritis.

    Science.gov (United States)

    Azadegan-Dehkordi, Fatemeh; Bagheri, Nader; Shirzad, Hedayatollah; Rafieian-Kopaei, Mahmoud

    2015-04-01

    T helper (Th) cells as an important part of the immune is responsible for elimination of invading pathogens. But, if Th cell responses are not regulated effectively, the autoimmune diseases might develop. The Th17 subset usually produces interleukin-17A which in experimental models of organ-specific autoimmune inflammation is very important. Directory of open access journals (DOAJ), Google Scholar, Embase, Scopus, PubMed and Web of Science have been searched. Fifty-six articles were found and searched. In the present review article, we tried to summarize the recently published data about characteristics and role of Th1 and Th17 cells and discuss in detail, the potential role of these T helpers immune responses in renal inflammation and renal injury, focusing on glomerulonephritis. Published papers in animal and human studies indicated that autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, classically believed to be Th1-mediated, are mainly derived from a Th17 immune response. Identification of the Th17 subgroup has explained seemingly paradoxical observations and improved our understanding of immune-mediated inflammatory responses. Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset. There is experimental evidence to support the notion that Th1 and Th17 cells contribute to kidney injury in renal inflammatory diseases like glomerulonephritis.

  8. Preliminary results of a recent cruise to the Northern Central Indian Ridge

    Digital Repository Service at National Institute of Oceanography (India)

    Drolia, R; Iyer, S.D.; Chakraborty, B.; Kodagali, V.N.; Mukhopadhyay, R; Nanyasi, S.K.; Sarma, K.V.L.N.S.; Rajasekhar, R; Misra, S.; Ray, Dwijesh; Andrade, R; Lasitha, S.; Varghese, J.; Jacob, J.; Sukumaran, N.P.; Pednekar, A.; Furtado, R; Nair, A.

    . This paper is published with the permission of the Directors of NIO and NGRI. The project is funded by the United States India Fund through ONR Grant # N 00014-97-I-0925. References Cande S.C. and Kent D.V. 1995, Revised calibration of the geomagnetic... al., 2000), results of reconnaissance survey during 28 th cruise of R/V Sonne (1983), no data of significance is available from the study areas. In the NCIR lacunae exist con- cerning plate kinematics, segmenta- tion pattern, petrologic variations...

  9. The California Central Coast Research Partnership: Building Relationships, Partnerships, and Paradigms for University-Industry Research Collaboration

    Science.gov (United States)

    2009-03-30

    two undergraduate students. These students have presented these results at local scientific meetings in posters or oral presentations. We will present...conference 2007, at Cal State LA, on November 17th, 2007. The poster is shown below: 211 ONR Grant No. N00014-06-1-11 1 1 P.I.: Susan C. Opava, Ph.D...34#" State I: check for Data output designator "@" State2: receive sample number high byte, which we dont care about State 3: reveive sample number low

  10. What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

    Directory of Open Access Journals (Sweden)

    Campos-Neto A.

    2005-01-01

    Full Text Available The T helper cell type 1 (Th1 response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.

  11. U-Th isotopic systematics at 13deg N east Pacific Ridge segment

    International Nuclear Information System (INIS)

    Ben Othman, D.; Allegre, C.J.

    1990-01-01

    Fresh basaltic glasses have been analyzed for U-Th disequilibrium systematics as part of an extensive study on the East Pacific Rise (EPR) at 12deg 45'N. These samples are well described in terms of major and trace elements as well as in Nd, Pb and Sr isotopes. Our results show significant heterogeneities in the mantle source at a small scale, and show heterogeneities at larger scales also when compared to other EPR data. U and Th concentration and isotopic data rule out fractional crystallization as a main process and support a mixing model in agreement with the marble cake model developed by Allegre and Turcotte and constrained by trace elements and Nd, Sr and Pb isotopes on the same samples by Prinzhofer et al. Based on the high ( 230 Th/ 232 Th) isotopic ratios on recent tholeiites especially the Th/U values inferred for their sources clearly show that the upper mantle Th/U has decreased with time. (orig.)

  12. FOREWORD: The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009) The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009)

    Science.gov (United States)

    Orlando, Thomas M.; Diebold, Ulrike

    2010-03-01

    The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) took place from 19-23 April 2009 in Pine Mountain, Georgia, USA. This was the 12th conference in a strong and vibrant series, which dates back to the early 1980s. DIET XII continued the tradition of exceptional interdisciplinary science and focused on the study of desorption and dynamics induced by electronic excitations of surfaces and interfaces. The format involved invited lectures, contributed talks and a poster session on the most recent developments and advances in this area of surface physics. The Workshop International Steering Committee and attendees wish to dedicate DIET XII to the memory of the late Professor Theodore (Ted) Madey. Ted was one of the main pioneers of this field and was one of the primary individuals working to keep this area of science exciting and adventurous. His overall contributions to surface science were countless and his contributions to the DIET field and community were enormous. He is missed and remembered by many friends and colleagues throughout the world. The papers collected in this issue cover many of the highlights of DIET XII. Topics include ultrafast electron transfer at surfaces and interfaces, quantum and spatially resolved mapping of surface dynamics and desorption, photon-, electron- and ion-beam induced processes at complex interfaces, the role of non-thermal desorption in astrochemistry and astrophysics and laser-/ion-based methods of examining soft matter and biological media. Although the workshop attracted many scientists active in the general area of non-thermal surface processes, DIET XII also attracted many younger scientists (i.e., postdoctoral fellows, advanced graduate students, and a select number of advanced undergraduate students). This field has had an impact in a number of areas including nanoscience, device physics, astrophysics, and now biophysics. We believe that this special issue of Journal of Physics

  13. ONR Far East Scientific Bulletin. Volume 12, Number 2, April-June 1987,

    Science.gov (United States)

    1987-06-01

    are oxidized strontium titanate as well as at least in part responsible for the out of TiO 2 . It appears that the TiO2 Japanese productivity. I saw...satcom equipment graduate students. There are 40 r.- at C and Ku bands; color TV transmit- specialists and 35 research institutes. - 4 ters; FM...RESOLUTION TEST CH4ART H~. AT AL BUREAU Of STANDARDS 1963 -A ’iwW -wW- % % . .*.. .. % - . . . . .* ** * ** * designed and built for a fishing 5 percent

  14. Determination of 228Th, 230Th, and 232Th in environmental samples from uranium mining and milling operations

    International Nuclear Information System (INIS)

    Durham, R.W.; Joshi, S.R.

    1979-01-01

    A method is described for the determination of 228 Th, 230 Th, and 232 Th in environmental samples from uranium mining and milling operations. The analytical procedure is based on the direct determination of 228 Th in the sample by high resolution γ-spectrometry followed by extraction and purification of the thorium fraction using high molecular weight amines and an anion-exchange technique, respectively, prior to α-spectrometry to determine isotopic ratios. The lowest level of detection for each thorium isotope is 0.01 pCi/g for solid samples and 20 pCi/l for aqueous samples. Replicate analyses of a typical mine waste stream gave a standard deviation of +-3% for 228 Th. Standard deviations of the 230 Th and 232 Th increased to +-11% apparently due to traces of 210 Po interfering in the α-spectrometry. (author)

  15. Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161(+)Th1 Cells) to CD161(+)Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients.

    Science.gov (United States)

    Kotake, Shigeru; Nanke, Yuki; Yago, Toru; Kawamoto, Manabu; Kobashigawa, Tsuyoshi; Yamanaka, Hisashi

    2016-01-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone with elevated levels of proinflammatory cytokines. It has been reported that IL-17 and Th17 cells play important roles in the pathogenesis of RA. Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells. It remains to be elucidated whether this conversion occurs in the early phase of RA. Here, we tried to identify Th17 cells, Th1 cells, and Th17 cell-derived Th1 cells (CD161(+)Th1 cells) in the peripheral blood of early-onset RA patients. We also evaluated the effect of methotrexate on the ratio of Th17 cells in early-onset RA patients. The ratio of Th17 cell-derived Th1 cells to CD161(+)Th17 cells was elevated in the peripheral blood of early-onset RA patients. In addition, MTX reduced the ratio of Th17 cells but not Th1 cells. These findings suggest that IL-17 and Th17 play important roles in the early phase of RA; thus, anti-IL-17 antibodies should be administered to patients with RA in the early phase.

  16. 12th International Symposium on Frontiers of Fundamental Physics

    CERN Document Server

    Michelini, Marisa; Santi, Lorenzo; FFP12; Frontiers of fundamental physics and physics education research

    2014-01-01

    In a knowledge-based society, research into fundamental physics plays a vital role not only in the enhancement of human knowledge but also in the development of new technology that affects everday life.The international symposium series Frontiers of Fundamental Physics (FFP) regularly brings together eminent scholars and researchers working in various areas in physics to exchange expertise, ideas, results, and new research perspectives. The twelfth such symposium, FFP12, took place at the University of Udine, Italy, and covered diverse fields of research: astrophysics, high energy physics and particle physics, theoretical physics, gravitation and cosmology, condensed matter physics, statistical physics, computational physics, and mathematical physics. Importantly, it also devoted a great deal of attention to physics education research, teacher training in modern physics, and popularization of physics. The high scientific level of FFP12 was guaranteed by the careful selection made by scientific coordinators fr...

  17. Analytical Methods for Determining the Motion of a Rigid Body Equipped with Internal Motion-Sensing Transducers

    Science.gov (United States)

    1976-10-01

    should be easily converted into software for use on high-speed digital computers. Since no readily available references were found containing relationships...L31 Library 1 ONR Boston 4 NSWC, White Oak 1 J.E. Goeller 1 ONR Chicago 1 V.C.D. Dawson 1 H.K. Steves 1 ONR Pasadena 1 Libary 1 NRL/CODE 2627 Lib 1

  18. Th1-Th17 Ratio as a New Insight in Rheumatoid Arthritis Disease.

    Science.gov (United States)

    Bazzazi, Hadi; Aghaei, Mehrdad; Memarian, Ali; Asgarian-Omran, Hossein; Behnampour, Nasser; Yazdani, Yaghoub

    2018-02-01

    The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in comparison with 22 healthy controls, the percentages of Th17, Th1 and dual Th17/Th1 cells were determined by flow-cytometry and their correlations were investigated with disease activity score (DAS28). Moreover, serum levels of IL-6 and IL-17 as inducer and functional cytokines for Th17 were investigated. Finally, serum levels of anti citrullinated protein antibody (ACPA) and rheumatoid factor (RF) were assessed. Percentage of Th17 cells in RA patients were increased in comparison with healthy controls (pTh1 cells in RA patients were less than healthy group (pTh17/Th1 cell only in new cases of RA were more than healthy control groups (pTh1/Th17 ratio in RA patients is statistically different with healthy control group (pTh1/Th17 ratio in RA patient suggested a new paradigm in the field of autoimmune disease and indicated that imbalance or plasticity between these subsets can be important in progress, diagnosis and therapy of RA disease.

  19. Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells.

    Science.gov (United States)

    Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid; de Souza, Gustavo Antonio

    2016-03-01

    T-helper cells are differentiated from CD4+ T cells and are traditionally characterized by inflammatory or immunosuppressive responses in contrast to cytotoxic CD8+ T cells. Mass-spectrometry studies on T-helper cells are rare. In this study, we aimed to identify the proteomes of human Th1 and Th1/Th17 clones derived from intestinal biopsies of Crohn's disease patients and to identify differentially expressed proteins between the two phenotypes. Crohn's disease is an inflammatory bowel disease, with predominantly Th1- and Th17-mediated response where cells of the "mixed" phenotype Th1/Th17 have also been commonly found. High-resolution mass spectrometry was used for protein identification and quantitation. In total, we identified 7401 proteins from Th1 and Th1/Th17 clones, where 334 proteins were differentially expressed. Major differences were observed in cytotoxic proteins that were overrepresented in the Th1 clones. The findings were validated by flow cytometry analyses using staining with anti-granzyme B and anti-perforin and by a degranulation assay, confirming higher cytotoxic features of Th1 compared with Th1/Th17 clones. By testing a larger panel of T-helper cell clones from seven different Crohn's disease patients, we concluded that only a subgroup of the Th1 cell clones had cytotoxic features, and these expressed the surface markers T-cell-specific surface glycoprotein CD28 and were negative for expression of natural killer group 2 member D. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  20. Catalyseurs et procédés catalytiques utilisés dans la production des grands intermédiaires pétrochimiques. Situation actuelle et futur Catalysts and Catalytic Processes Used for the Production of the Major Petrochemical Building Blocks. Present Situation and the Future

    Directory of Open Access Journals (Sweden)

    Boitiaux J. P.

    2006-11-01

    Full Text Available La pétrochimie représente une part modeste du marché des catalyseurs, mais les dix dernières années ont vu des améliorations substantielles des catalyseurs et des procédés utilisés. Ces améliorations ont permis de mieux répondre à la demande en grands intermédiaires pétrochimiques. Cette évolution est bien illustrée par les hydrogénations, autour du vapocraquage destiné à produire des oléfines, par le reformage catalytique et les procédés satellites destinés à produire des aromatiques et par les nouveaux procédés de déshydrogénation, métathèse, oligomérisation. . . qui permettent de mieux équilibrer le marché des oléfines. Petrochemicals account for a modest share of the market for catalysts, but there have been substantial improvements in the catalysts and processes used in the last ten years. These improvements have brought about a better response to the demand for major petrochemical building blocks. This trend is clearly illustrated by hydrogenations in the field of steam cracking to produce olefins, by catalytic reforming and satellite processes to produce aromatics, and by new processes such as dehydrogenation, metathesis and oligomerization which provide better balance to the market for olefins.

  1. The effects of Nigella sativa powder (black seed) and Echinacea ...

    African Journals Online (AJOL)

    ajl yemi

    2011-12-19

    Dec 19, 2011 ... was supplemented with EP at the rate of 0.25 ml/kg body weight (BW). Body ..... values in laying hen with references to fertility in cockerels. Proc of 7th ... under high temperature conditions 2- black cumin (Nigella Sativa) or.

  2. Influence of Zr substitution on the stabilization of ThMn12-type (Nd1−αZrα(Fe0.75Co0.2511.25Ti0.75N1.2−1.4 (α = 0–0.3 compounds

    Directory of Open Access Journals (Sweden)

    N. Sakuma

    2016-05-01

    Full Text Available The influence of Zr substitution in ThMn12 compounds was investigated using strip casting alloys. It was found that Zr substitution stabilized (Nd1−αZrα(Fe0.75Co0.2511.25Ti0.75N1.2−1.4 (α = 0–0.3 compounds. Specifically, a reduction in the lattice constant along the a-axis was observed. Energy-dispersive X-ray spectroscopy mapping combined with Cs-corrected scanning transmission electron microscopy indicated that Zr atoms preferentially occupied Nd 2a sites. Both the magnetic anisotropy field and saturation polarization were maximum at Zr substitution ratio α = 0.1. The (Nd1−αZrα(Fe0.75Co0.2511.25Ti0.75N1.2−1.4 (α = 0–0.3 compounds displayed higher saturation polarization than Nd2Fe14B at high temperatures.

  3. Modelo natural de dicotomía TH1-TH2: La enfermedad de Hansen Th1-TH2 balance. Natural model: Hansen'disease

    Directory of Open Access Journals (Sweden)

    N. L Vaquero

    2010-09-01

    Full Text Available La enfermedad de Hansen producida por el Mycobacterium leprae, es una enfermedad infecciosa cuyo amplio espectro clínico e inmunopatológico se correlaciona con los diferentes patrones de respuesta Th1/Th2. La activación preferencial de esas subpoblaciones de linfocitos T CD4 juega un rol importante en su patogenia y constituye un modelo natural de esa dicotomía de la respuesta inmune. Ambas formas polares de la lepra presentan un perfil definido de secreción de citoquinas: Th1 (IL2 e IFN? en el polo tuberculoide y Th2 (IL4, IL5, IL10 en el polo lepromatoso. En el primer caso, la respuesta celular adecuada estimula la activación macrofágica y lleva a la destrucción del bacilo. Las lesiones son escasas y limitadas a la piel y nervios periféricos. En el segundo en cambio, la respuesta celular es casi nula y los bacilos se multiplican descontroladamente dentro de los macrófagos, llevando a la diseminación de las lesiones y afectación de otros órganos. La inmunidad humoral está exacerbada y hay un alto nivel de anticuerpos que no pueden eliminar el germen intracelular. Los factores que determinan la diferenciación hacia una respuesta Th1 ó Th2 no se han esclarecido totalmente. Se han postulado varias hipótesis que hacen referencia a factores genéticos, prevalencia de citoquinas en el microambiente celular, disfunción macrofágica; alteración en los receptores Toll de la inmunidad innata, en la expresión de moléculas coestimulatorias, etc En los últimos años se han descubierto nuevas subpoblaciones de linfocitos, (CD4+ CD25+, Tr1, Th3 y Th17 que estarían implicadas en la desregulación de estas respuestas inmunes.Hansen' disease, caused by Mycobacterium leprae, is an infectious illness whose wide clinical and immunopathologic spectrum correl with different Th1/Th2 responses patterns. The prefferencial activation of the CD4 T cells subset play an important rol in it's pathogenia and provides a natural model of that balance

  4. 30th Winter Workshop on Nuclear Dynamics

    CERN Document Server

    2014-01-01

    The 30th edition of the Winter Workshop will be held April 6-12th, 2014 in Hotel Galvez & Spa, Galveston, Texas, USA. As with previous years, the workshop will bring together scientists from all fields of nuclear physics for engaging and friendly exchanges of ideas.Much emphasis will be on the recent LHC and RHIC heavy ion results, but advances in the ongoing and future programs at FAIR, FRIB, NICA and JLab will also be featured. The meeting will start with a welcome reception on the evening of Sunday, April 6th. The workshop program will commence on Monday morning and run until Saturday evening. We recommend to arrive on Sunday and leave on Sunday. Talks will be as usual 25+5 minutes, there will be no parallel sessions. If you are interested in presenting your work, please fill out the registration form prior to the registration deadline. After the program committee has met we will confirm your talk via individual invitations. We will also work with the talks committees of all relevant experimenta...

  5. PROPRIETES DU SOL ET DOMESTICATION DE Lippia multiflora ...

    African Journals Online (AJOL)

    AISA

    Lippia multiflora (Verbenaceae) communement connu sous le nom de « thé de savane », offre une diversité d'usages en pharmacopée et en médecine. Toutefois, en dépit d'un intérêt grandissant, le thé de savane demeure un produit de cueillette. Dès lors, il apparaît opportun de procéder à sa domestication, dans une.

  6. 12th September 2011 - Undersecretary for Foreign Affairs F. Schmidt Ariztía in the ATLAS visitor centre with ATLAS Collaboration Former Spokesperson P. Jenni, Adviser for Chile J. Salicio Diez and Senior Physicist J. Mikenberg.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    12th September 2011 - Undersecretary for Foreign Affairs F. Schmidt Ariztía in the ATLAS visitor centre with ATLAS Collaboration Former Spokesperson P. Jenni, Adviser for Chile J. Salicio Diez and Senior Physicist J. Mikenberg.

  7. Air-sea interaction over the tropical Indian Ocean during several contrasting monsoon seasons

    Digital Repository Service at National Institute of Oceanography (India)

    RameshKumar, M.R.; Sastry, J.S.

    stream_size 12 stream_content_type text/plain stream_name Proc_Indian_Acad_Sci_(EPS)_99_393.pdf.txt stream_source_info Proc_Indian_Acad_Sci_(EPS)_99_393.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  8. Chronology of 3rd–5th Century Female Graves from Tarasovo Burial Ground

    Directory of Open Access Journals (Sweden)

    Goldina Rimma D.

    2017-07-01

    Full Text Available The article represents the concluding part a series of works by the authors on the dating of burials from the unique 1st–5th century Tarasovo burial ground in the Middle Kama region. The first article was dedicated to the chronology of graves dating back to the early Nyrgynda stage (1st–2nd centuries of this monument. The second and third publications feature an analysis of the chronology of 3rd–5th century male burials. The present work describes 160 female burials of 3rd–5th centuries analyzed from the perspective of chronology. Similarly to previous research, the three main methods employed by the authors of this research include those of formal typology, cultural stratigraphy and the nearest neighbour method. A total of 12 chronological groups were singled out as a result: 1st half of 3rd century A.D. (group 1; 2nd half of 3rd century (2; 3rd century (3; 4th century (group 4; 2nd half of 3rd–4th centuries (5а; 3rd–4th centuries (5б; 1st half of 5th century (6; 2nd half of 5th century (7; 5th century (group 8; 2nd half of 4th–5th centuries (9; 4th–5th centuries (10; 2nd half of 3rd–5th centuries

  9. Upregulation of bacterial-specific Th1 and Th17 responses that are enriched in CXCR5+CD4+ T cells in non-small cell lung cancer.

    Science.gov (United States)

    Ma, Qin-Yun; Huang, Da-Yu; Zhang, Hui-Jun; Wang, Shaohua; Chen, Xiao-Feng

    2017-11-01

    The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examined the Th1 and Th17 responses toward several bacterial antigens, in CD4 + T cells sourced from the peripheral blood (PB), the lung cancer (LC) tissue, and the gastrointestinal (GI) tract of non-small cell lung cancer (NSCLC) patients. Compared to healthy controls, the NSCLC patients presented significantly higher frequencies of Th1 and Th17 cells reacting to Streptococcus salivarius and S. agalactiae, in the PB, LC, and GI tract. Further investigation showed that the upregulation in anti-bacteria response was likely antigen-specific for two reasons. Firstly, the frequencies of Th1 and Th17 cells reacting to Escherichia coli, a typical GI bacterium, were not upregulated in the PB and the LC of NSCLC patients. Secondly, the S. salivarius and S. agalactiae responses could be partially blocked by Tü39, a MHC class II blocking antibody, suggesting that antigen-specific interaction between CD4 + T cells and antigen-presenting cells was required. We also found that S. salivarius and S. agalactiae could potently activate the monocytes to secrete higher levels of interleukin (IL)-6, IL-12, and tumor necrosis factor, which were Th1- and Th17-skewing cytokines. Interestingly, whereas CXCR5 + CD4 + T cells represented <20% of total CD4 + T cells, they represented 17%-82% of bacteria-specific Th1 or Th17 cells. Together, these data demonstrated that NSCLC patients presented a significant upregulation of bacterial-specific Th1 and Th17 responses that were enriched in CXCR5 + CD4 + T cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Gamma Spectrometric Determination of U, Th, K and Some Geochemical Applications

    International Nuclear Information System (INIS)

    Dodona, A.; Tashko, A.

    2001-01-01

    The application of 'in situ' gamma-spectrometric method (''infinite'' environment), made possible the simultanious determination of U, Th and K. 4 channel gamma-spectrometric analyser with NaI(TI) scintilation counter crystal detector (103 cm 3 φ=50x50mm) was used to determin U, Th(more than 1-2 ppm) and K (more than 1%) in laboratory conditions. The detector was inserted into a lead camera and calibrated for measurement geometry with vessel of ''Marineli'' type of a 17o cm 3 volume. The study of main factors, which influence in the gamma spectrometric measurements, (the technical, physical, geometrical and time parameters) has been carried out. International standards of U, Th, K and internal monitoring standard samples are used for the calibration. External analytical control has been realized by other radiometric and chemical methods. The detection limits ( 1 ppm Th, 2ppm U and 1% K) and the relative errors (17-20% for 1-10 ppm U, Th and 10-15% for more than 10 ppm U, Th and more than 1% K) guarantee a quantitative analysis that may be used successfully in the geochemical studies. Some geochemical applications, based on the content of Th, U and Th/U ratio in rocks samples that we have we have analyzed with this method, are shown in this paper. U, Th and their ratio are used as trace elements to indicate the differences between the acidic magmatic rocks of Albania (Th/U ratio=2-6 and>10). The bimodal character of Th/U scattering in ignimbrides and monzonites (Korabi zone) shows that in addition to the ''normal'' rocks, there are also some ones enriched with Th, So, the differential analysis of Th, U, and K may be used as geochemical exploration criteria for the radioactive and non-radioactive mineralization, such as REE (Rare Earth Elements), phospghorites, bauxites, placers etc. (authors)

  11. Mountain-Scale Coupled Processes (TH/THC/THM)

    International Nuclear Information System (INIS)

    Dixon, P.

    2004-01-01

    The purpose of this Model Report is to document the development of the Mountain-Scale Thermal-Hydrological (TH), Thermal-Hydrological-Chemical (THC), and Thermal-Hydrological-Mechanical (THM) Models and evaluate the effects of coupled TH/THC/THM processes on mountain-scale UZ flow at Yucca Mountain, Nevada. This Model Report was planned in ''Technical Work Plan (TWP) for: Performance Assessment Unsaturated Zone'' (BSC 2002 [160819], Section 1.12.7), and was developed in accordance with AP-SIII.10Q, Models. In this Model Report, any reference to ''repository'' means the nuclear waste repository at Yucca Mountain, and any reference to ''drifts'' means the emplacement drifts at the repository horizon. This Model Report provides the necessary framework to test conceptual hypotheses for analyzing mountain-scale hydrological/chemical/mechanical changes and predict flow behavior in response to heat release by radioactive decay from the nuclear waste repository at the Yucca Mountain site. The mountain-scale coupled TH/THC/THM processes models numerically simulate the impact of nuclear waste heat release on the natural hydrogeological system, including a representation of heat-driven processes occurring in the far field. The TH simulations provide predictions for thermally affected liquid saturation, gas- and liquid-phase fluxes, and water and rock temperature (together called the flow fields). The main focus of the TH Model is to predict the changes in water flux driven by evaporation/condensation processes, and drainage between drifts. The TH Model captures mountain-scale three dimensional (3-D) flow effects, including lateral diversion at the PTn/TSw interface and mountain-scale flow patterns. The Mountain-Scale THC Model evaluates TH effects on water and gas chemistry, mineral dissolution/precipitation, and the resulting impact to UZ hydrological properties, flow and transport. The THM Model addresses changes in permeability due to mechanical and thermal disturbances in

  12. Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy.

    Science.gov (United States)

    Abelius, Martina S; Lempinen, Esma; Lindblad, Karin; Ernerudh, Jan; Berg, Göran; Matthiesen, Leif; Nilsson, Lennart J; Jenmalm, Maria C

    2014-06-01

    The influence of the intra-uterine environment on the immunity and allergy development in the offspring is unclear. We aimed to investigate (i) whether the pregnancy magnifies the Th2 immunity in allergic and non-allergic women, (ii) whether the maternal chemokine levels during pregnancy influenced the offspring's chemokine levels during childhood and (iii) the relationship between circulating Th1/Th2-associated chemokines and allergy in mothers and children. The Th1-associated chemokines CXCL9, CXCL10, CXCL11, and the Th2-associated chemokines CCL17, CCL18 and CCL22 were quantified by Luminex and ELISA in 20 women with and 36 women without allergic symptoms at gestational week (gw) 10-12, 15-16, 25, 35, 39 and 2 and 12 months post-partum and in their children at birth, 6, 12, 24 months and 6 years of age. Total IgE levels were measured using ImmunoCAP Technology. The levels of the Th2-like chemokines were not magnified by pregnancy. Instead decreased levels were shown during pregnancy (irrespectively of maternal allergy status) as compared to post-partum. In the whole group, the Th1-like chemokine levels were higher at gw 39 than during the first and second trimester and post-partum. Maternal CXCL11, CCL18 and CCL22 levels during and after pregnancy correlated with the corresponding chemokines in the offspring during childhood. Increased CCL22 and decreased CXCL10 levels in the children were associated with sensitisation and increased CCL17 levels with allergic symptoms during childhood. Maternal chemokine levels were not associated with maternal allergic disease. Allergic symptoms and sensitisation were associated with decreased Th1- and increased Th2-associated chemokine levels during childhood, indicating a Th2 shift in the allergic children, possibly influenced by the maternal immunity during pregnancy. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Nineth Rib Syndrome after 10th Rib Resection

    OpenAIRE

    Yu, Hyun Jeong; Jeong, Yu Sub; Lee, Dong Hoon; Yim, Kyoung Hoon

    2016-01-01

    The 12th rib syndrome is a disease that causes pain between the upper abdomen and the lower chest. It is assumed that the impinging on the nerves between the ribs causes pain in the lower chest, upper abdomen, and flank. A 74-year-old female patient visited a pain clinic complaining of pain in her back, and left chest wall at a 7 on the 0-10 Numeric Rating scale (NRS). She had a lateral fixation at T12-L2, 6 years earlier. After the operation, she had multiple osteoporotic compression fractur...

  14. Highlights from the 7th European Meeting on Molecular Diagnostics

    NARCIS (Netherlands)

    Dr. A.J.C. van den Brule, van den; Drs A.J.M. Loonen; Dr. R. Schuurman

    2012-01-01

    This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics

  15. Reflexions sociològiques figuratives i de procés sobre l’esport i la globalització: algunes observacions conceptuals i teòriques, amb especial referència al futbol

    OpenAIRE

    Dunning, Eric

    2009-01-01

    Aquest article es divideix en tres parts. La primera consisteix en un comentari conceptual teòric sobre la globalització i en diversos exemples del món globalitzat de l’esport; la segona és un comentari sobre el desenvolupament i l’extensió global del futbol; i la tercera exposa el comentari d’algunes patologies relacionades amb l’esport. Tot al llarg de l’article s’aplica l’enfocament sociològic figuratiu i de procés desenvolupat per Norbert Elias. En resum, aquest treball és fonamentalment ...

  16. 12th International Conference on Informatics in Control, Automation and Robotics

    CERN Document Server

    Gusikhin, Oleg; Madani, Kurosh; Sasiadek, Jurek

    2016-01-01

    The present book includes a set of selected extended papers from the 11th International Conference on Informatics in Control, Automation and Robotics (ICINCO 2014), held in Vienna, Austria, from 1 to 3 September 2014. The conference brought together researchers, engineers and practitioners interested in the application of informatics to Control, Automation and Robotics. Four simultaneous tracks will be held, covering Intelligent Control Systems, Optimization, Robotics, Automation, Signal Processing, Sensors, Systems Modelling and Control, and Industrial Engineering, Production and Management. Informatics applications are pervasive in many areas of Control, Automation and Robotics. ICINCO 2014 received 301 submissions, from 49 countries, in all continents. After a double blind paper review performed by the Program Committee, 20% were accepted as full papers and thus selected for oral presentation. Additional papers were accepted as short papers and posters. A further selection was made after the Conference, ba...

  17. Nuclear performance optimization of the Be/Li/Th blanket for the fusion breeder

    International Nuclear Information System (INIS)

    Lee, J.D.; Bandini, B.R.

    1985-01-01

    More rigorous nuclear analysis, including treatment of resonance self-shielding effects coupled with an optimization procedure, has resulted in improved performance of the Be/Li/Th blanket. Net U-233 breeding ratio has increased 36% (to 0.84) while at an average U-233/Th ratio of 0.5 a/o average energy multiplication has increased only 12% (to 2.1) compared with earlier results

  18. Usage of Metaphors in Turkish Language Textbooks Used at 6th, 7th and 8th Grades

    Directory of Open Access Journals (Sweden)

    Esra Karakas

    2013-05-01

    Full Text Available The word “Metaphor”, which is equivalent to the terms “istiare” in Arabic or “eğretileme, transfer of idioms” in Turkish, consists of two parts. “Meta” means “later” or “with” whereas “phora” means transfer or conveyance of word. In the recent years metaphor has been the subject and focuses of several studies, and is used to express a concept or situation with another concept or situation. Starting from 1980s, researchers have studied metaphor and concurrently they examined usage of language. It is now been believed that using metaphors is appropriate in order to be able to understand any phenomenon. Metaphor can be used in encouraging learning and improving creative thinking; it can also provide hints for in-the-class methods, techniques and situations. In this context, metaphors are also essential components for Turkish language textbooks. The purpose of this study is to detect the uses of metaphor in Turkish language textbooks of 6th, 7th and 8th grade students. For this purpose the Turkish language textbooks of 6th, 7th and 8th grade students prepared by the Ministry of National Education (MEB were examined with “content analysis method. Considering that metaphors are effective in learning and improving creative thinking, the importance of using metaphors in textbooks is beyond discussion. The data collected throughout this study show that the metaphors detected in 7th and 8th grade Turkish language textbooks are less in number compared to those found in 6th grade Turkish language textbooks. Another important conclusion is that distribution of metaphors among units is not even. The conclusion of the study is that Turkish language textbooks are not prepared in a sensitive and choosy manner with this respect.

  19. Radiological impact due to natural radionuclides (U and Th-isotopes) in soils from Salamanca, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Mandujano G, C. D.; Sosa, M. [Universidad de Guanajuato, Division de Ciencias e Ingenierias, Loma del Bosque 103, Col. Lomas del Campestre, 37150 Leon, Guanajuato (Mexico); Mantero, J.; Manjon, G.; Garcia T, R. [Universidad de Sevilla, Grupo en Fisica Nuclear Aplicada, Av. Reina Mercedes No. 2, 41012 Sevilla (Spain); Costilla, R., E-mail: cmandujano@fisica.ugto.mx [Universidad de Guanajuato, Division de Ciencias de la Vida, Departamento de Ciencias Ambientales, Ex-Hacienda El Copal Km 9 Irapuato-Silao, 36500 Irapuato, Guanajuato (Mexico)

    2015-10-15

    Full text: Activity concentrations of U ({sup 238}U, {sup 234}U) and Th ({sup 232}Th, {sup 230}Th) radionuclides in samples of superficial urban soils surrounding an industrial complex in Salamanca, Mexico have been determined. Levels of naturally occurring radionuclides (Norm) in the environment may be affected due to the presence of different industrial activities in this zone, representing a potential radiological risk for the population which should be evaluated. Alpha-particle Spectrometry with Pips detectors has been used for the radiometric characterization. A well established radiochemical procedure was used for the isolation of the radionuclides of interest. Alkali fusion for sample digestion, liquid-liquid extraction with Tbp (tri-butyl-phosphate) for U and Th isolation and electrodeposition in stainless steel dishes for measurement conditioning has been used. The results cover the ranges of 10-42, 12-60, 12-52 and 11-51 Bq·kg{sup -1} for {sup 238}U, {sup 234}U, {sup 230}Th, and {sup 232}Th respectively, being not observed any clear anthropogenic increments in relation with the values normally found in unaffected soils. Although there is disequilibrium between U isotopes and {sup 230}Th in some soil samples, it can be attributed to natural processes. The radiological impact of the industrial activities in the surrounding soils can be then evaluated as very low. Hence, from the Radiological Protection point of view, the soils studied do not represent a radiological risk for the health of the population. (Author)

  20. Relics of continental lithosphere in the atlantic by data of (Th/U)th, (Th/U)pb, and K/Ti systematics

    International Nuclear Information System (INIS)

    Titayeva, N.A.; Mironov, Y.

    1996-01-01

    The problem of mantle heterogeneity of the Atlantic Ocean has been investigated. Th/U ratio is a sensitive geochemical tracer. This ratio can be calculated from 232Th/230Th or from 208Pb/206Pb since 230Th and 206Pb are decay product of 238U and 208Pb is a product of 232Th decay. The former way to get Th/U ratio is valid for quaternary volcanic rocks because of the relatively short 230Th half life (80000 years), the latter way gives an integral quantity characterizing the pre-oceanic history beginning from the onset of earth formation and ending about 150 million years ago. Clear distinctions between ''depleted oceanic'' and ''enriched continental'' reservoirs have been drawn from comparative analysis of rocks. (A.C.)

  1. Inorganic Species Behaviour in Thermochemical Processes for Energy Biomass Valorisation Comportement des espèces inorganiques dans les procédés thermochimiques de valorisation énergétique de la biomasse

    Directory of Open Access Journals (Sweden)

    Froment K.

    2013-09-01

    difficulties (corrosion, fouling, etc.: a detailed summary of the specific behaviour of the inorganic compounds in biomass thermal conversion facilities will be given, going from the description of inorganic species included in biomass up to the prevention and the solution, as far as possible. The following topics will therefore be developed: inventory of inorganic species in different biomasses; general review of the inorganic speciation during thermal conversion processes; technological barriers to overcome for economic and technological process improvements; specific aspects related to inorganic species behaviour investigated at CEA: inorganic species release and condensation; aerosol behaviour and deposits; hot particles filtration; slag formation and interactions with reactor wall. Les espèces inorganiques de la biomasse (bois, déchets agricoles, déchets ménagers voire boues d’épuration présentent un large spectre en compositions et quantités, dépendant de l’origine de la biomasse (nature, lieux et conditions de sa croissance, etc.. Les différents procédés de conversion (combustion, pyrolyse, gazéification, etc. et les différentes technologies associées (fours à grille, lits fixes ou fluidisés, réacteurs à flux entraînés, etc. utilisant l’énergie de la biomasse, fournissent des conditions opératoires très variées en atmosphère, température, pression, etc. Au cours de chacun de ces procédés thermiques de conversion, en fonction de la composition initiale de la biomasse, de l’atmosphère et la température du procédé (la pression est un paramètre de second ordre par rapport aux précédents, certaines espèces inorganiques réagissent pour former des composés liquides ou gazeux, seuls ou combinés à d’autres espèces : celles-ci peuvent être soit piégées à différents endroits dans le procédé, soit relâchées avec le gaz. Les interactions potentielles de ces espèces inorganiques avec les parois des réacteurs, les mat

  2. X-ray spectral study of the Th6p,5f electron states in ThO2 and ThF4

    International Nuclear Information System (INIS)

    Teterin, Y.A.; Nikitin, A.S.; Teterin, A.Y.; Ivanov, K.E.; Utkin, I.O.; Nerehov, V.A.; Ryzhkov, M.V.; Vukchevich, I.J.

    2002-01-01

    The study of the Th6p,5f electron states in Th, ThO 2 and ThF was carried out on the basis of the X-ray photoelectron fine spectral structure parameters in the binding energy range of 0-∼ 1000 eV, X-ray O 4,5 (Th) emission spectra of the shallow (0-∼50 eV) electrons and results of theoretical calculations. As a result, despite the absence of the Th5f electrons in thorium atoms, the Th5f atomic orbitals were established to participate in the formation of molecular orbitals in thorium dioxide and tetrafluoride. In the MO LCAO approximation this allowed to suggest the possible existence of filled Th5f electronic states in thorium compounds. On the basis of the X-ray O 4,5 (Th) emission spectral structure parameters the effective formation of the inner valence molecular orbitals in the studied compounds was confirmed. (authors)

  3. Self-consistent electric field effect on electron transport of ECH plasmas

    International Nuclear Information System (INIS)

    Chan, V.S.; Murakami, S.

    1999-02-01

    An algorithm is proposed which treats the ECH generated potential in a self-consistent way, by extending the Monte-Carlo Fokker-Planck method used by Murakami [S. Murakami et al., Proc. 17th IAEA Fusion Energy Conference, Yokohama, 1998 (International Atomic Energy Agency, Vienna, in press), paper CN-69/TH2/1]. The additional physics is expected to influence the transport of both thermal and suprathermal electrons in a helical toroidal system. (author)

  4. Difference Schemes and Applications

    Science.gov (United States)

    2015-02-06

    for hypersonic air flows in thermochemical nonequilibrium. 1995. A Collection of Technical Papers of 6th Int. Symp. on CFD . V. 2. Lake Tahoe, Nevada...for complex configurations”// (1983), AIAA Paper 83-1929, Proc. AIAA 6 th CFD Conf., Danvers, MA, pp. 293-302. 3. Johnson F.T., Kamenetskiy D.S...Robust CFD Codes”// Mathematical Modelling of Natural Phenomena, (2011), 6(03), pp. 2-27, doi:10.1051/mmnp/20116301 Distribution A: Approved for

  5. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice

    Directory of Open Access Journals (Sweden)

    Chen-Chen Lee

    2015-01-01

    Full Text Available This study investigated the immunomodulatory effects of ferulic acid (FA on antigen-presenting dendritic cells (DCs in vitro and its antiallergic effects against ovalbumin- (OVA- induced Th2-mediated allergic asthma in mice. The activation of FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS stimulation induced a high level of interleukin- (IL- 12 but reduced the expression levels of the proinflammatory cytokines IL-1β, IL-6, and tumor necrosis factor- (TNF- α. Compared to control-treated DCs, FA significantly enhanced the expressions of Notch ligand Delta-like 4 (Dll4, MHC class II, and CD40 molecules by these DCs. Furthermore, these FA-treated DCs enhanced T-cell proliferation and Th1 cell polarization. In animal experiments, oral administration of FA reduced the levels of OVA-specific immunoglobulin E (IgE and IgG1 and enhanced IgG2a antibody production in serum. It also ameliorated airway hyperresponsiveness and attenuated eosinophilic pulmonary infiltration in dose-dependent manners. In addition, FA treatment inhibited the production of eotaxin, Th2 cytokines (IL-4, IL-5, and IL-13, and proinflammatory cytokines but promoted the Th1 cytokine interferon- (IFN- γ production in bronchoalveolar lavage fluid (BALF and the culture supernatant of spleen cells. These findings suggest that FA exhibits an antiallergic effect via restoring Th1/Th2 imbalance by modulating DCs function in an asthmatic mouse model.

  6. Switched Current Micropower 4th Order Lowpass / Highpass Filter

    DEFF Research Database (Denmark)

    Bogason, Gudmundur

    1993-01-01

    This paper describes a 4th order lowpass / highpass Butterworth filter implemented in switched current technique. The filter has been designed for low power operation. A prototype implementation has been made and it operates with supply voltages down to 2V and with a total supply current of 211Â......¿A at a sampling rate of 50kHz. The chip includes a clock-generator, three current-followers, sample-and-hold and two 4th order filters. The sampling frequency is restricted to approximately 50kHz and the ratio between sampling frequency and cutoff frequency is 12.5. The dynamic-range was found to be 49d...

  7. The beneficial effect of total glucosides of paeony on psoriatic arthritis links to circulating Tregs and Th1 cell function.

    Science.gov (United States)

    Wang, Yi Na; Zhang, Yu; Wang, Yan; Zhu, Ding Xian; Xu, Li Qin; Fang, Hong; Wu, Wei

    2014-03-01

    Total glycosides of peony (TGP) is a natural immuno-modulatory drug extracted from traditional Chinese herb peony. It has been approved by State Food and Drug Administration for the treatment of rheumatoid arthritis. However, data of TGP effect on psoriatic arthritis (PsA) is still scarce. In this study, 19 patients with PsA received 12-week treatment of TGP, and clinical efficacy in joint manifestations was evaluated by DAS28 at weeks 0, 4, 8 and 12. Peripheral percentages of Tregs, Th1, Th2 and NK cells were analyzed, and serum Th1-type cytokines (IL-12, IFN-γ and TNF-α), Th2-type cytokines (IL-4, IL-5 and IL-10) as well as pro-inflammatory factors (IL-2, IL-6 and IL-8) were concomitantly examined. Six patients (32%) exhibited ≥25% decrease of DAS28 (responders). Interestingly, all responders displayed a continuous decrease in Treg and Th1 numbers during TGP treatment, concomitant with significant decreases in Th1-type cytokine levels. Serum IL-6 also showed a significant decline in responders. Non-responders lacked these sequential alterations. Thus, TGP merits further consideration as a promising therapeutic option for PsA. The result indicated that recovery of Tregs and Th1 may serve as prognostic markers to assess responsiveness to TGP treatment in PsA. Copyright © 2013 John Wiley & Sons, Ltd.

  8. Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

    Science.gov (United States)

    Chen, Renxiang; Wang, Yi-Wen; Fornace, Albert J; Li, Heng-Hong

    2016-12-01

    Two major CD4 + T-helper (Th) lineages are Th1 and Th2, and well balanced Th1/Th2 responses are essential for immune function. In previously published studies, it was reported that radiation induces a Th1/Th2 immune imbalance toward a Th2-dominant direction, and this imbalance may contribute to postirradiation immune dysfunction. The polarization of Th cells is driven by the cytokine milieu and controlled by intracellular regulatory pathways that respond to cytokine signaling. It is widely accepted that radiation induces cytokine aberration, however, the precise alterations of cytokines in various tissue environments have been difficult to evaluate. In addition, the effects of radiation on the intrinsic functions of Th cells remain uncharacterized. Therefore, how radiation affects Th1/Th2 balance remains somewhat unclear. To address this, we investigated the changes in the polarization capability of Th cells by isolating them from mice previously exposed to radiation and assessing the cells in an established in vitro Th polarization system. Our novel results demonstrate that prior exposure to radiation led to the persistent aberration of the inherent capability of Th cells to differentiate into Th1 and Th2 lineages. The parallel changes in expression of Th1-specific master transcription factors and the key genes in metabolic reprograming indicated that radiation affects the core components in Th1 polarization. While Th1 differentiation was impaired after irradiation, little adverse effect was observed in Th2 differentiation; both of these findings contribute to the known phenotypes of Th1/Th2 imbalance caused by radiation.

  9. 24th Current Trends in Computational Chemistry

    Science.gov (United States)

    2017-05-17

    Corps of Engineers Army Research Office Conference on Current Trends in Computational Chemistry 2016 NOVEMBER 11-12, 2016 JACKSON, MS... Chemistry and Biochemistry Jackson, MS 39217 U.S.A. Tel: 6019793723 E-mail: shonda@icnanotox.org Richard Alo Dean College of Science, Engineering ...Report: 24th Current Trends in Computational Chemistry The views, opinions and/or findings contained in this report are those of the author(s) and should

  10. Role of Th1 and Th2 cells in autoimmune demyelinating disease

    NARCIS (Netherlands)

    Nagelkerken, L.

    1998-01-01

    Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of

  11. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA) (12th, Maynooth, Greater Dublin, Ireland, October 24-26, 2015)

    Science.gov (United States)

    Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

    2015-01-01

    These proceedings contain the papers of the 12th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2015), October 24-26, 2015, which has been organized by the International Association for Development of the Information Society (IADIS), co-organized by Maynooth University, Ireland, and endorsed by the…

  12. An exploration of advanced X-divertor scenarios on ITER

    Science.gov (United States)

    Covele, B.; Valanju, P.; Kotschenreuther, M.; Mahajan, S.

    2014-07-01

    It is found that the X-divertor (XD) configuration (Kotschenreuther et al 2004 Proc. 20th Int. Conf. on Fusion Energy (Vilamoura, Portugal, 2004) (Vienna: IAEA) CD-ROM file [IC/P6-43] www-naweb.iaea.org/napc/physics/fec/fec2004/datasets/index.html, Kotschenreuther et al 2006 Proc. 21st Int. Conf. on Fusion Energy 2006 (Chengdu, China, 2006) (Vienna: IAEA), CD-ROM file [IC/P7-12] www-naweb.iaea.org/napc/physics/FEC/FEC2006/html/index.htm, Kotschenreuther et al 2007 Phys. Plasmas 14 072502) can be made with the conventional poloidal field (PF) coil set on ITER (Tomabechi et al and Team 1991 Nucl. Fusion 31 1135), where all PF coils are outside the TF coils. Starting from the standard divertor, a sequence of desirable XD configurations are possible where the PF currents are below the present maximum design limits on ITER, and where the baseline divertor cassette is used. This opens the possibility that the XD could be tested and used to assist in high-power operation on ITER, but some further issues need examination. Note that the increased major radius of the super-X-divertor (Kotschenreuther et al 2007 Bull. Am. Phys. Soc. 53 11, Valanju et al 2009 Phys. Plasmas 16 5, Kotschenreuther et al 2010 Nucl. Fusion 50 035003, Valanju et al 2010 Fusion Eng. Des. 85 46) is not a feature of the XD geometry. In addition, we present an XD configuration for K-DEMO (Kim et al 2013 Fusion Eng. Des. 88 123) to demonstrate that it is also possible to attain the XD configuration in advanced tokamak reactors with all PF coils outside the TF coils. The results given here for the XD are far more encouraging than recent calculations by Lackner and Zohm (2012 Fusion Sci. Technol. 63 43) for the Snowflake (Ryutov 2007 Phys. Plasmas 14 064502, Ryutov et al 2008 Phys. Plasmas 15 092501), where the required high PF currents represent a major technological challenge. The magnetic field structure in the outboard divertor SOL (Kotschenreuther 2013 Phys. Plasmas 20 102507) in the recently created

  13. Evaluation of carcass traits, non-carcass components and 12th rib analysis of hair sheep supplemented with phosphorus Avaliação das características de carcaça, constituintes corporais e da 12ª costela de ovinos deslanados suplementados com fósforo

    Directory of Open Access Journals (Sweden)

    Helder Louvandini

    2006-04-01

    Full Text Available The aim of this study was to evaluate the performance of sheep supplemented with phosphorus (P using carcass traits and analysis of 12th rib. Twenty male lambs weighing 13.88 ± 2.51 kg and grazing Andropogon gayanus pasture were divided in two treatments of 10 animals each. In group P, animals were supplemented with 3 g phosphorus/animal/day, while in group NP no P supplementation was given. After 82 days the animals were slaughtered and carcass measurements were taken. The 12th rib was also removed for analysis. No significant differences in body weight, carcass yield, or commercial cut weights were found between both treatments, except for liver and kidneys that were heavier in the supplemented group (p=0.0954. The 12th rib analysis showed that the group P had higher rib, bone, and muscle weights when compared to animals not supplemented with P. Other measurements such as carcass fatness and rib eye area were not significantly affected by treatments as well as contents of crude protein, ether extract, ash and P. It was shown that P supplementation improved performance in young sheep, including bone and muscle tissue and liver and kidney weights.Este trabalho foi realizado com a finalidade de avaliar o desempenho de ovinos suplementados com fósforo (P, utilizando-se as análises das características de carcaça e da 12ª costela. Foram utilizados 20 ovinos com 13,88 ± 2,51 kg de PV, mantidos em pastagem de Andropogon gayanus, distribuídos em dois tratamentos com dez animais: um com suplementação de 3g/fósforo/animal/dia e o outro sem suplementação. Após 82 dias, os animais foram abatidos, tomando-se as medidas da carcaça e da 12ª costela, para posterior análise. Não foram encontradas diferenças significativas entre os valores de peso vivo, rendimento de carcaça, cobertura de gordura e cortes comerciais entre os dois tratamentos, exceto os pesos do fígado e dos rins, que foram superiores (p=0,0954 no grupo suplementado. Na an

  14. A method for predicting errors when interacting with finite state systems. How implicit learning shapes the user's knowledge of a system

    International Nuclear Information System (INIS)

    Javaux, Denis

    2002-01-01

    This paper describes a method for predicting the errors that may appear when human operators or users interact with systems behaving as finite state systems. The method is a generalization of a method used for predicting errors when interacting with autopilot modes on modern, highly computerized airliners [Proc 17th Digital Avionics Sys Conf (DASC) (1998); Proc 10th Int Symp Aviat Psychol (1999)]. A cognitive model based on spreading activation networks is used for predicting the user's model of the system and its impact on the production of errors. The model strongly posits the importance of implicit learning in user-system interaction and its possible detrimental influence on users' knowledge of the system. An experiment conducted with Airbus Industrie and a major European airline on pilots' knowledge of autopilot behavior on the A340-200/300 confirms the model predictions, and in particular the impact of the frequencies with which specific state transitions and contexts are experienced

  15. Proceedings of the 10th International Symposium on Laser Spectroscopy

    International Nuclear Information System (INIS)

    2002-01-01

    This proceedings contains articles of the 10th International Symposium on Laser Spectroscopy. It was held on 1-2 Nov 2002 in Taejeon, Korea. The main topics are as follows: Laser Isotope, Laser Spectroscopy, Laser Fusion, Laser Applications and so on. (Yi, J. H.)

  16. Average Power and Brightness Scaling of Diamond Raman Lasers

    Science.gov (United States)

    2012-01-07

    J. Appl. Phys. 92(2), 649–653 (2002). 26. J. Smedley , C. Jaye, J. Bohon, T. Rao, and D. A. Fischer, “Laser patterning of diamond. Part II. Surface...nondiamond carbon formation and its removal,” J. Appl. Phys. 105(12), 123108 (2009). 27. J. Smedley , J. Bohon, Q. Wu, and T. Rao, “Laser patterning...Singh, Dianyuan Fan, Jianquan Yao, Robert F. Walter, Proc. of SPIE Vol. 8551, 85510U · © 2012 SPIE CCC code: 0277-786/12/$18 · doi: 10.1117/12.999857 Proc

  17. The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation

    Directory of Open Access Journals (Sweden)

    Shang Li

    2018-01-01

    Full Text Available Purpose. CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs. The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods. A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry. The related cytokines in aqueous humor were also analyzed. Results. The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group. And the expression trend of CD4+LAP+ T cells and CD4+GARP+ T cells was consistent. The level of IFN-γ, TNF, IL-6, and IL-17A markedly increased in aqueous humor during corneal allograft rejection. The ratio of Th1/Th2 and Th17/LAP+Tregs significantly increased in the rejection group at the 3rd week after corneal transplantation. Conclusion. LAP+Tregs might be regarded as substitute for Foxp3+Tregs. The balance of Th1/Th2 and LAP+Tregs/Th17 is crucial for corneal allograft survival.

  18. 12th Symposium on Space Nuclear Power and Propulsion. Conference on Alternative Power from Space (APFS),Conference on Accelerator-Driven Transmutation Technologies and Applications (A-DTTA)

    International Nuclear Information System (INIS)

    Mohamed, S.E.

    1995-01-01

    These proceedings represent papers presented at the 12th symposium on Space Nuclear Power and Propulsion held in Albuquerque, New Mexico. The symposium theme was ''commercialization and technology transfer''. The topics discussed include: wireless power transmission, solar power from space next generation spacecraft, space power electronics and power management, flight testing of components, manufacturing and processing of materials, nuclear propulsion, reactors and shielding and many others of interest to the scientific community representing industry, government and academic institutions. There were 163 papers presented at the conference and 60 have been abstracted for the Energy Science and Technology database

  19. 12th International Conference on Second Messengers and Phosphoproteins

    Czech Academy of Sciences Publication Activity Database

    Tuháčková, Zdena

    2004-01-01

    Roč. 32, č. 3 (2004), s. 89-91 ISSN 1211-2526. [International conference on second messengers and phosphoproteins /12./. Montreal, 03.08.2004-07.08.2004] R&D Projects: GA ČR GA301/04/0550; GA AV ČR KSK5020115 Institutional research plan: CEZ:AV0Z5052915 Keywords : MTOR -PI3-K signalling * p70 S 6 kinase * v-Src Subject RIV: CE - Biochemistry

  20. Psychological Sciences Division 1979 Programs.

    Science.gov (United States)

    1979-11-01

    currently available techniques. Funding: ONR, AFHRL Molenaar , I.W. A fast solution of the Lindley equations for the M-group regression problem (Tech. Rep...late 1979. Funding: will be issued, and selected papers are scheduled ONR, NPRDC, AFOSR for publication as a book . Funding: ONR, NPRDC, AFOSR, ARI... book describing the LB phenomenon approach to performance assessment: II. An investigation of based on experiments with over a thousand sub- encoding

  1. 38th Annual Maintenance & Operations Cost Study for Schools

    Science.gov (United States)

    Agron, Joe

    2009-01-01

    Despite the worst economic environment in generations, spending by K-12 institutions on maintenance and operations (M&O) held its own--defying historical trends that have shown M&O spending among the most affected in times of budget tightening. This article presents data from the 38th annual Maintenance & Operations Cost Study for…

  2. Preventative effect of an herbal preparation (HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation.

    Science.gov (United States)

    Kim, Jong-Jin; Cho, Hyun Wook; Park, Hae-Ran; Jung, Uhee; Jo, Sung-Kee; Yee, Sung-Tae

    2013-01-01

    HemoHIM, an herbal preparation of three edible herbs (Angelica gigas Nakai, Cnidium officinale Makino, Paeonia japonica Miyabe) is known to increase the Th1 immune response as well as reduce the allergic response in human mast cells. Here, our goal was to determine whether or not HemoHIM could induce Th1 cell differentiation as well as inhibit the development of airway inflammation. To study Th1/Th2 cell differentiation, naive CD4(+) T cells isolated from C57BL/6 mouse spleens were cultured with or without HemoHIM. To examine airway inflammation, C57BL/6 mice were fed HemoHIM for 4 weeks before sensitization and provocation with ovalbumin (OVA). In an in vitro experiment, naive CD4(+) T cells displayed increased Th1 (IFN-γ(+) cell) as well as decreased Th2 (IL-4(+) cell) differentiation in a HemoHIM concentration-dependent manner. Furthermore, in an airway inflammation mice model, eosinophil numbers in BALF, serum levels of OVA-specific IgE and IgG1, and cytokine (IL-4, IL-5, and IL-13) levels in BALF and the supernatant of splenocytes all decreased upon HemoHIM (100 mg/kg body weight) pretreatment (4 weeks). These results show that HemoHIM attenuated allergic airway inflammation in the mouse model through regulation of the Th1/Th2 balance.

  3. Preventative effect of an herbal preparation (HemoHIM on development of airway inflammation in mice via modulation of Th1/2 cells differentiation.

    Directory of Open Access Journals (Sweden)

    Jong-Jin Kim

    Full Text Available HemoHIM, an herbal preparation of three edible herbs (Angelica gigas Nakai, Cnidium officinale Makino, Paeonia japonica Miyabe is known to increase the Th1 immune response as well as reduce the allergic response in human mast cells. Here, our goal was to determine whether or not HemoHIM could induce Th1 cell differentiation as well as inhibit the development of airway inflammation. To study Th1/Th2 cell differentiation, naive CD4(+ T cells isolated from C57BL/6 mouse spleens were cultured with or without HemoHIM. To examine airway inflammation, C57BL/6 mice were fed HemoHIM for 4 weeks before sensitization and provocation with ovalbumin (OVA. In an in vitro experiment, naive CD4(+ T cells displayed increased Th1 (IFN-γ(+ cell as well as decreased Th2 (IL-4(+ cell differentiation in a HemoHIM concentration-dependent manner. Furthermore, in an airway inflammation mice model, eosinophil numbers in BALF, serum levels of OVA-specific IgE and IgG1, and cytokine (IL-4, IL-5, and IL-13 levels in BALF and the supernatant of splenocytes all decreased upon HemoHIM (100 mg/kg body weight pretreatment (4 weeks. These results show that HemoHIM attenuated allergic airway inflammation in the mouse model through regulation of the Th1/Th2 balance.

  4. Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine.

    Science.gov (United States)

    Nagayama, Yuji; Mizuguchi, Hiroyuki; Hayakawa, Takao; Niwa, Masami; McLachlan, Sandra M; Rapoport, Basil

    2003-04-01

    Graves' hyperthyroidism has long been considered to be a Th2-type autoimmune disease because it is directly mediated by autoantibodies against the thyrotropin receptor (TSHR). However, several lines of evidence have recently challenged this concept. The present study evaluated the Th1/Th2 paradigm in Graves' disease using a recently established murine model involving injection of adenovirus expressing the TSHR (AdCMVTSHR). Coinjection with adenovirus expressing IL-4 (AdRGDCMVIL-4) decreased the ratio of Th1/Th2-type anti-TSHR Ab subclasses (IgG2a/IgG1) and suppressed the production of IFN-gamma by splenocytes in response to TSHR Ag. Importantly, immune deviation toward Th2 was accompanied by significant inhibition of thyroid-stimulating Ab production and reduction in hyperthyroidism. However, in a therapeutic setting, injection of AdRGDCMVIL-4 alone or in combination with AdCMVTSHR into hyperthyroid mice had no beneficial effect. In contrast, coinjection of adenoviruses expressing IL-12 and the TSHR promoted the differentiation of Th1-type anti-TSHR immune responses as demonstrated by augmented Ag-specific IFN-gamma secretion from splenocytes without changing disease incidence. Coinjection of adenoviral vectors expressing IL-4 or IL-12 had no effect on the titers of anti-TSHR Abs determined by ELISA or thyroid-stimulating hormone-binding inhibiting Ig assays, suggesting that Ab quality, not quantity, is responsible for disease induction. Our observations demonstrate the critical role of Th1 immune responses in a murine model of Graves' hyperthyroidism. These data may raise a cautionary note for therapeutic strategies aimed at reversing Th2-mediated autoimmune responses in Graves' disease in humans.

  5. Electromagnetic field effects in explosives

    Science.gov (United States)

    Tasker, Douglas

    2009-06-01

    Present and previous research on the effects of electromagnetic fields on the initiation and detonation of explosives and the electromagnetic properties of explosives are reviewed. Among the topics related to detonating explosives are: measurements of conductivity; enhancement of performance; and control of initiation and growth of reaction. Hayes...()^1 showed a strong correlation of peak electrical conductivity with carbon content of the detonation products. Ershov.......^2 linked detailed electrical conductivity measurements with reaction kinetics and this work was extended to enhance detonation performance electrically;...^3 for this, electrical power densities of the order of 100 TW/m^2 of explosive surface normal to the detonation front were required. However, small electrical powers are required to affect the initiation and growth of reaction.......^4,5 A continuation of this work will be reported. LA-UR 09-00873 .^1 B. Hayes, Procs. of 4th Symposium (International) on Detonation (1965), p. 595. ^2 A. Ershov, P. Zubkov, and L. Luk'yanchikov, Combustion, Explosion, and Shock Waves 10, 776-782 (1974). ^3 M. Cowperthwaite, Procs. 9th Detonation Symposium (1989), p. 388-395. ^4 M. A. Cook and T. Z. Gwyther, ``Influence of Electric Fields on Shock to Detonation Transition,'' (1965). ^5 D. Salisbury, R. Winter, and L. Biddle, Procs. of the APS Topical Conference on Shock Compression of Condensed Matter (2005) p. 1010-1013.

  6. The Relationship of Grade Span in 9th Grade to Math Achievement in High School

    Science.gov (United States)

    West, John; Miller, Mary Lou; Myers, Jim; Norton, Timothy

    2015-01-01

    Purpose, Scope, and Method of Study: The purpose of this study was to determine if a correlation exists between grade span for ninth grade and gains in math achievement test scores in 10th grade and 12th grade. A quantitative, longitudinal, correlational research design was employed to investigate the research questions. The population was high…

  7. 77 FR 9927 - Filing Dates for the Arizona Special Election in the 8th Congressional District

    Science.gov (United States)

    2012-02-21

    ... 8th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Special Primary and Special General Election on June 12, 2012, shall file a 12-day Pre-Primary Report, a... Elections shall file a 12-day Pre-Primary Report on April 5, 2012; a 12-day Pre-General Report on May 31...

  8. Thermal expansion studies on Th(MoO4)2, Na2Th(MoO4)3 and Na4Th(MoO4)4

    International Nuclear Information System (INIS)

    Keskar, Meera; Krishnan, K.; Dahale, N.D.

    2008-01-01

    Thermal expansion behavior of Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 was studied under vacuum in the temperature range of 298-1123 K by high temperature X-ray diffractometer. Th(MoO 4 ) 2 was synthesized by reacting ThO 2 with 2 mol of MoO 3 , at 1073 K in air and Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were prepared by reacting Th(MoO 4 ) 2 with 1 and 2 mol of Na 2 MoO 4 , respectively at 873 K in air. The XRD data of Th(MoO 4 ) 2 was indexed on orthorhombic system where as XRD data of Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were indexed on tetragonal system. The lattice parameters and cell volume of all the three compounds, fit into polynomial expression with respect to temperature, showed positive thermal expansion (PTE) up to 1123 K. The average value of thermal expansion coefficients for Th(MoO 4 ) 2 , Na 2 Th(MoO 4 ) 3 and Na 4 Th(MoO 4 ) 4 were determined from the high temperature data

  9. CERN receives early 50th anniversary present from Swiss Confederation

    CERN Multimedia

    2003-01-01

    "Swiss President Pascal Couchepin announced Wednesday 4 June an early 50th birthday present from the Swiss Confederation to CERN. Switzerland has decided to offer the laboratory the 'Palais de l'Equilibre', a landmark building designed by Geneva architects for Switzerland's 2002 national exhibition" (1/2 page).

  10. World War II never ended in my house: interviews of 12 Office of Strategic Services veterans of wartime espionage on the 50th anniversary of WW II.

    Science.gov (United States)

    Cavin, Susan

    2006-07-01

    The author conducted sociological interviews of 12 OSS spies (7 male, 5 female) who were operatives in France during World War II (WW II). The Office of Strategic Services (OSS) existed from 1941 to 1945 and was later renamed the CIA in 1947. This paper includes family studies of six close relatives of OSS vets and observation of 400 OSS veterans at the 50th anniversary of WW II. Three of the 12 OSS veterans who had been tortured by the Gestapo still suffered from PTSD-startle symptoms after 50 years; those three also suffered massive strokes in later life. The majority of OSS vets, regardless of gender, exhibited "war excitement" when talking about the war 50 years later. Most saw the war as the highpoint of their lives. War excitement needs more careful study within PTSD circles.

  11. Proceedings of the 11th China symposium on computer application in modern science and technology

    International Nuclear Information System (INIS)

    2003-01-01

    The 11th China symposium on computer application in modern science and technology were held by China Electronics Society and Nuclear Electronics and Nuclear Detecting Technology branch Society of China Nuclear Society on september, 8th-12th, 2003 in Changdao of Shandong province 77 articles is collected in the proceedings. The contents included calculation and calculation method, software system and software application, data acquisition and control system, database, and management information system, general system, network application and grid calculation and its application system and so on

  12. Work in progress: a channel selection algorithm for a TVWS mesh network

    CSIR Research Space (South Africa)

    Zlobinsky, Natasha

    2016-09-01

    Full Text Available and routing for throughput optimization in multi-radio wireless mesh networks,” Proc. 11th Annu. Int. Conf. Mob. Comput. Netw. - MobiCom ’05, p. 58, 2005. [4] M. R. Rai, S. Vahid, and K. Moessner, “SINR based Topology Control for Multihop Wireless Networks...

  13. CrossTalk: The Journal of Defense Software Engineering. Volume 19, Number 11

    Science.gov (United States)

    2006-11-01

    8>. 7. Wallace, Delores R. Practical Soft- ware Reliability Modeling. Proc. of the 26th Annual NASA Goddard Software Engineering Workshop, Nov. 2001...STAR WARS TO STAR TREK To Request Back Issues on Topics Not Listed Above, Please Contact <stsc. customerservice@hill.af.mil>. About the Authors Kym

  14. Sharp Adams-type inequality invoking Hardy inequalities

    Indian Academy of Sciences (India)

    Mohamed Khalil Zghal

    2018-03-22

    Mar 22, 2018 ... Proc. Indian Acad. Sci. (Math. Sci.) (2018) 128:13 ... where ∇ j u denotes the j-th order gradient of u, namely. ∇ j u = { j. 2 u if j is even, ... As emphasized above, Proposition 1.1 has been at the origin of numerous applications.

  15. Physics in Europe--A Data File of Selected Research.

    Science.gov (United States)

    1984-06-18

    Negev Sapir Proc. 16th Euro. Conf. on Laser Interac. with Matter, London 26-30 Sept. 1983 1025 CPBICF laser plasma soft x-ray refractometry France...CPBICF laser plasma Schlieren diagnostic France 623 CPBICF laser plasma self focusing numerics UK 1025 CPBICF laser plasma soft x-ray refractometry

  16. Cartilage turnover reflected by metabolic processing of type II collagen

    DEFF Research Database (Denmark)

    Gudmann, Karoline Natasja Stæhr; Wang, Jianxia; Hoielt, Sabine

    2014-01-01

    The aim of this study was to enable measurement of cartilage formation by a novel biomarker of type II collagen formation. The competitive enzyme-linked immunosorbent assay (ELISA) Pro-C2 was developed and characterized for assessment of the beta splice variant of type II procollagen (PIIBNP). Th...

  17. Vitamin B 12 absorption: correction of intestinal retention by whole-body profile activity of vitamin B 12-58 cobalt and by double tracer technique

    International Nuclear Information System (INIS)

    Goncalves, M.R. Bencke; Gheldof, R.; Paternot, L. van Tricht; Delmotte, E.; Verschaeren, A.; Martin, P.; Verhas, M.; Universidade Federal, Rio de Janeiro, RJ

    1997-01-01

    Full text. Intestinal retention could give false negative results in determining the whole-body retention of vitamin B 12 absorption (WBC B12-58Co). After having validate the WBC B12-58Co, taking the Schilling test as reference, we have studied the feasibility to evaluate the intestinal contamination by measurement of the profile activity distribution of vitamin B12-58Co and by a double tracer technique (WBC B12-58Co/ WBC 51 Cr Cl3). Methodology: twenty five patients were studied for the setting up of the new methodology. For eleven of them the WBC B12-58 Co retention was measured at the 7th day after the oral administration of 37KBq of B12-58Co using a four detectors whole body counter. One week later, a Schilling test was performed after the oral absorption of 18,5 KBq B12-57Co. Results were expressed as %ID. In these patients, one single peak of hepatic activity was observed on the whole body profile and thus no further intestinal correction was needed. In order to evaluate the intestinal contribution, we made in nine other patients the profile of the whole body distribution of activity at 1 h, 1 week and two weeks after the oral administration of B12-58Co. For five other patients a double tracer technique was used for intestinal correction after the simultaneous oral administration of 37 KBq of B12-58Co and 1,85 MBq of 51 Cr Cl3. The B12-58Co absorption was evaluated after intestinal correction based on subtraction of the 51Cr Cl3 contribution after the formula: B12-58Co(%ID) = WBC B12-58Co - WBC 51 Cr Cl3/1 - WBC 51 Cr Cl3. Results: the correlation with the Schilling test was found excellent: r=0,94 (n=11). The normality for WBC retention (n=7) was define as 53,2 +-12,4% ID (SD). For nine patients studied at the 7th day, the presence of a double peak (hepatic and intestinal peaks) allowed the subtraction by exponential extrapolation; the correction range was 4,4% to 37,2%. With the exception of one observation there was no difference in the measure of vitamin

  18. Academic stress-induced changes in Th1- and Th2-cytokine response

    Directory of Open Access Journals (Sweden)

    Areej M. Assaf

    2017-12-01

    Full Text Available Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8 and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10 on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

  19. Academic stress-induced changes in Th1- and Th2-cytokine response.

    Science.gov (United States)

    Assaf, Areej M; Al-Abbassi, Reem; Al-Binni, Maysaa

    2017-12-01

    Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8) and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10) on 35 medical/health sciences students after completing their questionnaires was investigated. Blood samples were taken at three stages; baseline stage at the beginning, midterm and final academic examination stages. Plasma cortisol and cytokines were measured during the three stages. The last two stages were compared with the baseline non-stress period. Results of the stress induced during the final examination stage were the highest with a significant increase in cortisol release, IL-4, IL-5 and IL-1ra release with a shift in Th1:Th2 cytokines balance towards Th2. Whereby, the midterm stage did not show significant reduction in Th1-cytokines except for TNF-α, with an increase in IFN-γ level that was reduced in the third stage. Th2 cytokine, IL-1ra, had positive correlations with Th1 cytokines; IL-2 and IFN-γ in the second stage and IL-6 cytokine in the third stage. Cortisol was positively correlated with IL-8 in the last stage and heart rates had negative correlation with IL-10 in the first and last stages. Findings of this study indicate that exam stress down-regulates Th1 with a selective up-regulation of Th2-cytokines. In conclusion, Cortisol might have a role in suppressing the release of Th1- mediated cellular immune response which could increase the vulnerability among the students to infectious diseases.

  20. El procés d'avaluació i intervenció psicològica a pacients amb trastorns per abús d' alcohol i/o altres substàncies psicotròpiques

    OpenAIRE

    Trasovares Navarrete, María Victoria

    2004-01-01

    Aquest treball, realitzat al Centre d'Atenció i Seguiment de Drogodependències (CASD) de Nou Barris, ha tingut com a objectiu principal observar el rol del psicòleg clínic en el procés d'avaluació i intervenció psicoterapèutica en pacients que presenten un trastorn per dependència de substàncies psicotròpiques. Este trabajo, realizado en el Centro de Atención y Seguimiento de Drogodependencias (CASD) de Nou Barris, ha tenido como principal objetivo observar el rol del psicólogo clínico en ...

  1. Preventative Effect of an Herbal Preparation (HemoHIM) on Development of Airway Inflammation in Mice via Modulation of Th1/2 Cells Differentiation

    OpenAIRE

    Kim, Jong-Jin; Cho, Hyun Wook; Park, Hae-Ran; Jung, Uhee; Jo, Sung-Kee; Yee, Sung-Tae

    2013-01-01

    HemoHIM, an herbal preparation of three edible herbs (Angelica gigas Nakai, Cnidium officinale Makino, Paeonia japonica Miyabe) is known to increase the Th1 immune response as well as reduce the allergic response in human mast cells. Here, our goal was to determine whether or not HemoHIM could induce Th1 cell differentiation as well as inhibit the development of airway inflammation. To study Th1/Th2 cell differentiation, naive CD4(+) T cells isolated from C57BL/6 mouse spleens were cultured w...

  2. Asymmetrically deformed third minimum in the 231Th and 233Th fission barriers

    International Nuclear Information System (INIS)

    Blons, J.; Mazur, C.; Paya, D.; Ribrag, M.; Weigmann, H.

    1981-01-01

    Neutron induced fission cross-sections of 230 Th and 232 Th have been measured up to 5 MeV. The electron linear accelerator (GELINA) has been used as a neutron time of flight spectrometer with a nominal resolution of 84 psec/m for 230 Th(n,f) and 42 psec/m for 232 Th(n,f) reaction. The fission fragment detector was a 6 cell gas scintillator filled with xenon. The existence of fine structure peaks, a few keV wide, in both the 230 Th(n,f) and 232 Th(n,f) cross sections, is definitively confirmed. The analysis of the two vibrational resonances located respectively at 720 keV for 230 Th(the figure) and 1.6 MeV for 232 Th, shows clearly that these peaks can be interpreted, in terms of two rotational bands with opposite parities. This parity degeneracy is a consequence of the asymmetric, pear-like deformation of the excited nucleus [ru

  3. Effect of platinum-nanodendrite modification on the glucose-sensing properties of a zinc-oxide-nanorod electrode

    Energy Technology Data Exchange (ETDEWEB)

    Abdul Razak, Khairunisak, E-mail: khairunisak@usm.my [School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia); NanoBiotechnology Research & Innovation (NanoBRI), INFORMM, Universiti Sains Malaysia, 11800 USM, Penang (Malaysia); Neoh, Soo Huan; Ridhuan, N.S.; Mohamad Nor, Noorhashimah [School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang (Malaysia)

    2016-09-01

    Highlights: • Effect of PtNDs on ZnONRs/ITO glucose sensor was studied. • Well-defined PtNDs synthesis using 20 mM K{sub 2}PtCl{sub 4} produced good dispersion between nanodendrites with uniform particle size. • Nafion coating significantly improved the catalytic oxidation of glucose sensor. • Nafion/GO{sub x}/PtNDs/ZnONRs/ITO demonstrated better properties compared with Nafion/GO{sub x}/PtNDs/ITO and Nafion/GO{sub x}/ZnONRs/ITO electrodes. - Abstract: The properties of ZnO nanorods (ZnONRs) decorated with platinum nanodendrites (PtNDs) were studied. Various sizes of PtNDs were synthesized and spin coated onto ZnONRs, which were grown on indium–titanium–oxide (ITO) substrates through a low-temperature hydrothermal method. Scanning electron microscopy and X-ray diffraction analyses were conducted to analyze the morphology and structural properties of the electrodes. The effects of PtND size, glucose concentration, and Nafion amount on glucose-sensing properties were investigated. The glucose-sensing properties of electrodes with immobilized glucose oxidase (GO{sub x}) were measured using cyclic voltammetry. The bio-electrochemical properties of Nafion/GO{sub x}/42 nm PtNDs/ZnONRs/ITO glucose sensor was observed with linear range within 1–18 mM, with a sensitivity value of 5.85 μA/mM and a limit of detection of 1.56 mM. The results of this study indicate that PtNDs/ZnONRs/ITO has potential in glucose sensor applications.

  4. Circulating endothelial progenitor cells, Th1/Th2/Th17-related cytokines, and endothelial dysfunction in resistant hypertension.

    Science.gov (United States)

    Magen, Eli; Feldman, Arie; Cohen, Ziona; Alon, Dora Ben; Minz, Evegeny; Chernyavsky, Alexey; Linov, Lina; Mishal, Joseph; Schlezinger, Menacham; Sthoeger, Zev

    2010-02-01

    A possible link between chronic vascular inflammation and arterial hypertension is now an object of intensive studies. To compare Th1/Th2/Th17 cells-related cytokines, circulating endothelial progenitor cells (EPC), and endothelial function in subjects with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Blood pressure was measured by electronic sphygmomanometer. EPC were identified as CD34+/CD133+/kinase insert domain receptor (KDR)+ cells by flow cytometry. Th1/Th2/Th17 cells-related cytokines were identified using the Human Th1/Th2/Th17 Cytokines MultiAnalyte ELISArray Kit. Endothelium-dependent (FMD) vasodilatation of brachial artery was measured by Doppler ultrasound scanning. RAH group (n = 20) and CAH group (n = 20) and 17 healthy individuals (control group) were recruited. In the RAH group, lower blood levels of EPC number (42.4 +/- 16.7 cells/mL) and EPC% (0.19 +/- 0.08%) were observed than in the CAH group (93.1 +/- 88.7 cells/mL; P = 0.017; 0.27 +/- 0.17; P = 0.036) and control group (68.5 +/- 63.6 cells/mL; P < 0.001; 0.28 +/- 0.17%; P = 0.003), respectively. Plasma transforming growth factor-beta1 levels were significantly higher in the RAH group (1767 +/- 364 pg/mL) than in the CAH group (1292 +/- 349; P < 0.001) and in control group (1203 +/- 419 pg/mL; P < 0.001). In the RAH group, statistically significant negative correlation was observed between systolic blood pressure and EPC% (r = -0.72, P < 0.01). FMD in the RAH group was significantly lower (5.5 +/- 0.8%) than in the CAH group (9.2 +/- 1.4; P < 0.001) and in healthy controls (10.1 +/- 1.1%; P < 0.001). RAH is characterized by reduced circulating EPC, substantial endothelial dysfunction, and increased plasma transforming growth factor-beta1 levels.

  5. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.

    Science.gov (United States)

    Vuong, H E; Pérez de Sevilla Müller, L; Hardi, C N; McMahon, D G; Brecha, N C

    2015-10-29

    Transgenic mouse lines are essential tools for understanding the connectivity, physiology and function of neuronal circuits, including those in the retina. This report compares transgene expression in the retina of a tyrosine hydroxylase (TH)-red fluorescent protein (RFP) mouse line with three catecholamine-related Cre recombinase mouse lines [TH-bacterial artificial chromosome (BAC)-, TH-, and dopamine transporter (DAT)-Cre] that were crossed with a ROSA26-tdTomato reporter line. Retinas were evaluated and immunostained with commonly used antibodies including those directed to TH, GABA and glycine to characterize the RFP or tdTomato fluorescent-labeled amacrine cells, and an antibody directed to RNA-binding protein with multiple splicing to identify ganglion cells. In TH-RFP retinas, types 1 and 2 dopamine (DA) amacrine cells were identified by their characteristic cellular morphology and type 1 DA cells by their expression of TH immunoreactivity. In the TH-BAC-, TH-, and DAT-tdTomato retinas, less than 1%, ∼ 6%, and 0%, respectively, of the fluorescent cells were the expected type 1 DA amacrine cells. Instead, in the TH-BAC-tdTomato retinas, fluorescently labeled AII amacrine cells were predominant, with some medium diameter ganglion cells. In TH-tdTomato retinas, fluorescence was in multiple neurochemical amacrine cell types, including four types of polyaxonal amacrine cells. In DAT-tdTomato retinas, fluorescence was in GABA immunoreactive amacrine cells, including two types of bistratified and two types of monostratified amacrine cells. Although each of the Cre lines was generated with the intent to specifically label DA cells, our findings show a cellular diversity in Cre expression in the adult retina and indicate the importance of careful characterization of transgene labeling patterns. These mouse lines with their distinctive cellular labeling patterns will be useful tools for future studies of retinal function and visual processing. Published by Elsevier

  6. Research on the evaluation system for heat metering and existing residential building retrofits in northern regions of China for the 12th five-year period

    International Nuclear Information System (INIS)

    Xin, Liu; Yan, Ding; Yujia, Tong; Neng, Zhu; Zhe, Tian

    2014-01-01

    On the basis of ERBR (existing residential building retrofit) work in the 11th five-year period, energy efficiency retrofits for old residential buildings have been further promoted in northern regions of China during the 12th five-year period. ERBR projects are capable of not only achieving energy conservation and emissions reductions but also providing warmer rooms for residents during cold winters. Therefore, this project should be continued in northern regions of China following a long-term management mode. With the aim of exploring methods and mechanisms for the evaluation of the retrofit effect, an evaluation method was established with the application of the multi-level expert evaluation method. The evaluation indexes cover the aspects of policy mechanisms, financing modes and technical measures. A rewards and punishment mechanism according to the evaluation system was also suggested. Such an evaluation system can be used as a valuable reference for future implementation of energy efficiency retrofit work. - Highlights: • With the AHPD method, the evaluation system of the ERBR was set up to complete. • There are 29 indicators, including policies, financings and technologies. • Rewards and punishment mechanisms are offered to the ERBR. • For weight value more than 0.06, long-term practice and accumulation are needed

  7. effect of different prevein level on the land snail (achatina chatina ...

    African Journals Online (AJOL)

    RAJAH

    The foot (edible portion), the shell and the visceral materials were weighed separately for each snail. .... Biometrics.11: 1-42. Ejidike, B. N., 2001. Comparative effect of supplemental and complete diets on the performance of. African giant land snail. Archachatina marginata). Proc. 26th Ann. Conf. Nig. Soc. for. Anim. Prod.

  8. TREX13 Data Analysis/Modeling

    Science.gov (United States)

    2018-03-29

    From: Dajun Tang, Principal Investigator Subj: ONR Grant# N00014-14-1-0239 & N00014-16-1-2371, “TREX 13 Data analysis /Modeling” Encl: (1) Final...Performance/ Technical Report with SF298 The attached enclosures constitute the final technical report for ONR Grant# N00014-14-1-0239 & N00014-16-1-2371...TREX 13 Data analysis /Modeling” cc: Grant & Contract Administrator, APL-UW Office of Sponsor Programs, UW ONR Seattle – Robert Rice and

  9. Early Mongols – the Ethno-Political History to the 13th Century

    Directory of Open Access Journals (Sweden)

    Nenad Vidaković

    2015-04-01

    Full Text Available The paper examines the etnogenesis of the Mongol tribes from the period of the Rouran and Shiwei tribal alliances to the unification in the early 13th century under Genghis Khan’s leadership. The initial period of the ethnogenesis of medieval Mongols’ ancestors is associated with Rouran and Shiwei tribal alliances while news about them are written in Chinese dynastic chronicles. Within the Shiwei association there was the Mengwu tribe that inhabited forest expanses of north-western Manchuria, and the Argun river basin is considered to be the original homeland of the Mongols. The directions and time of migration processes which played an important role in the transformation of part of Mongol tribes from forest hunters to steppe nomads have been further investigated. The ethnic history of the Mongol tribes is closely associated with the Turkic and Tungus-Manchurian tribes. The Turkic tribes, that inhabited the steppes of Mongolia today, had a crucial importance in the development of Mongol nomadic tribes, while the Tungus-Manchu and northern Mongol tribes shared forest expanses of Manchuria and Trans-Baikal. The following text describes the events in the Turkic khaganates and kingdoms in the north of China, which influenced the historical development of the Mongol tribes. The period of the Qidan Liao dynasty (10th12th century is of great importance because the core of the Mongol nomadic tribes was formed at that time in the northeastern Mongolia, that were gradually spreading over the steps to the west. During the Jurchen Jin dynasty (12th ‒ 13th century the importance of the Mongol tribes in the steppe increased. The attempts of political unification of the Mongols appeared during that period – for the first time in the mid-12th century, during the reign of Khabul Khan. The final part of the paper describes the struggle of Temujin (Temüjin, the future Genghis Khan, for the unification of the Mongol-Turkic tribes. After victory over

  10. 78 FR 48869 - Filing Dates for the Massachusetts Special Elections in the 5th Congressional District

    Science.gov (United States)

    2013-08-12

    ... in the 5th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates... Special Primary and the Special General Election on December 10, 2013, shall file a 12-day Pre-Primary... Elections shall file a 12-day Pre-Primary Report on October 3, 2013; a 12-day Pre- General Report on...

  11. 77 FR 43823 - Filing Dates for the Michigan Special Election in the 11th Congressional District

    Science.gov (United States)

    2012-07-26

    ... 11th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Special Primary and Special General Election on November 6, 2012, shall file a 12-day Pre-Primary Report... Elections shall file a 12-day Pre-Primary Report on August 24, 2012; a 12-day Pre-General Report on October...

  12. Challenges of anamorphic high-NA lithography and mask making

    Science.gov (United States)

    Hsu, Stephen D.; Liu, Jingjing

    2017-06-01

    Chip makers are actively working on the adoption of 0.33 numerical aperture (NA) EUV scanners for the 7-nm and 5-nm nodes (B. Turko, S. L. Carson, A. Lio, T. Liang, M. Phillips, et al., in `Proc. SPIE9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 977602 (2016) doi: 10.1117/12.2225014; A. Lio, in `Proc. SPIE9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 97760V (2016) doi: 10.1117/12.2225017). In the meantime, leading foundries and integrated device manufacturers are starting to investigate patterning options beyond the 5-nm node (O. Wood, S. Raghunathan, P. Mangat, V. Philipsen, V. Luong, et al., in `Proc. SPIE. 9422, Extreme Ultraviolet (EUV) Lithography VI', vol. 94220I (2015) doi: 10.1117/12.2085022). To minimize the cost and process complexity of multiple patterning beyond the 5-nm node, EUV high-NA single-exposure patterning is a preferred method over EUV double patterning (O. Wood, S. Raghunathan, P. Mangat, V. Philipsen, V. Luong, et al., in `Proc. SPIE. 9422, Extreme Ultraviolet (EUV) Lithography VI', vol. 94220I (2015) doi: 10.1117/12.2085022; J. van Schoot, K. van Ingen Schenau, G. Bottiglieri, K. Troost, J. Zimmerman, et al., `Proc. SPIE. 9776, Extreme Ultraviolet (EUV) Lithography VII', vol. 97761I (2016) doi: 10.1117/12.2220150). The EUV high-NA scanner equipped with a projection lens of 0.55 NA is designed to support resolutions below 10 nm. The high-NA system is beneficial for enhancing resolution, minimizing mask proximity correction bias, improving normalized image log slope (NILS), and controlling CD uniformity (CDU). However, increasing NA from 0.33 to 0.55 reduces the depth of focus (DOF) significantly. Therefore, the source mask optimization (SMO) with sub-resolution assist features (SRAFs) are needed to increase DOF to meet the demanding full chip process control requirements (S. Hsu, R. Howell, J. Jia, H.-Y. Liu, K. Gronlund, et al., EUV `Proc. SPIE9048, Extreme Ultraviolet (EUV) Lithography VI', (2015) doi: 10.1117/12

  13. Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients.

    Science.gov (United States)

    Li, Qifeng; Zhang, Hui; Yu, Liang; Wu, Chao; Luo, Xinhui; Sun, He; Ding, Jianbing

    2018-01-01

    Th1/Th2 imbalance to Th2 is of significance in the peripheral immune responses in Tuberculosis (TB) development. However, the mechanisms for Th1/Th2 imbalance are still not well determined. Notch signaling pathway is involved in the peripheral T cell activation and effector cell differentiation. However, whether it affects Th1/Th2 imbalance in TB patients is still not known. Here, we used γ-secretase inhibitor (DAPT) to treat the peripheral blood mononuclear cells (PBMCs) from healthy people or individuals with latent or active TB infection in vitro, respectively. Then, the Th1/Th2 ratios were determined by flow cytometry, and cytokines of IFN-γ, IL-4, IL-10 in the culture supernatant were measured by CBA method. The Notch signal pathway associated proteins Hes1, GATA3 and T-bet were quantitated by real-time PCR or immunoblotting. Our results showed that DAPT effectively inhibited the protein level of Hes1. In TB patients, the Th2 ratio increased in the PBMCs, alone with the high expression of GATA3 and IL-4, resulting in the high ratios of Th2/Th1 and GATA3/T-bet in TB patients. However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3. But, its influence on Th1 ratio and Th1 related T-bet and IFN-γ levels were not significant. In conclusion, our results suggest that blocking Notch signaling by DAPT could inhibit Th2 responses and restore Th1/Th2 imbalance in TB patients. Copyright © 2017. Published by Elsevier B.V.

  14. Responses of Multi-Aged Music Students to Mid-20th-Century Art Music: A Replication and Extension

    Science.gov (United States)

    Madsen, Clifford K.; Geringer, John M.

    2015-01-01

    This investigation replicates previous research into K-12 students' responses to mid-20th-century art music. The study extends that research to include undergraduates and graduates as well as an additional group of graduate students who had taken a 20th-century music class. Children's responses showed remarkable consistency and indicated that…

  15. 17th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2012-01-01

    Cryocoolers 17 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 17th International Cryocooler Conference that was held in Los Angeles, California, on July 9-12, 2012. The program of this conference consisted of 94 papers; of these, 71 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  16. Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany.

    Science.gov (United States)

    Müller, M J; Baracos, V; Bosy-Westphal, A; Dulloo, A G; Eckel, J; Fearon, K C H; Hall, K D; Pietrobelli, A; Sørensen, T I A; Speakman, J; Trayhurn, P; Visser, M; Heymsfield, S B

    2014-08-01

    The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism. © 2014 The Authors. obesity reviews © 2014 World Obesity.

  17. CXCL12 expression in hematopoietic tissues of mice exposed to sublethal dose of ionizing radiation in the presence od iNOS inhibitor

    Energy Technology Data Exchange (ETDEWEB)

    Perez Vieira, Daniel [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Lab. de Biologia Molecular; Hermida, Felipe Pessoa de Melo; Andrade Junior, Heitor Franco de [Instituto de Medicina Tropical de Sao Paulo, SP (Brazil). Lab. de Protozoologia

    2005-07-01

    Full text of publication follows: We study the production of CXCL12, a stem cell homing chemokine, in spleen and bone marrow of mice exposed at LD50% of {gamma}-radiation, w/wo a iNOS blocker, aminoguanidine, to test if inflammatory nitric oxide is involved in necrotic processes of stem cell death after ionizing radiation exposure. Groups of 10 male 6-week old C57Bl/6j mice were killed at specific time points after a 8Gy dose irradiation ({sup 60}Co source; 4,22kGy/h dose rate) and spleen and bone marrow samples were immersed and stored in TriZOL for total mRNA extraction. RT-PCR assays were performed to determine the production of CXCL12 as compared to murine {beta}-actin at days 2nd, 5th, 7th, 9th and 15th days after radiation in a semiquantitative way. PCR was performed after cDNA synthesis using Oligo-dT primers and specific primers for CXCL12 and {beta}-actin. Artificial optical density was determined in silver-stained PAGE resolved specific amplification products of CXCL12, using amplification of murine {beta}-actin as standard, and measurements obtained by the Image J freeware. CXCL12 production in spleen samples reached its maximum at 5th day after radiation exposure in animals not treated with aminoguanidine, but this peak was extended to at 7th day in treated animals. Non treated animals presented a decrease of CXCL12 expression up to 15th day of experiment, and aminoguanidine treated animals showed sustained increase of expression levels between 9th and 15th days. In bone marrow samples, the main difference among the two different experimental groups was a maintenance of CXCL12 mRNA expression between 7th and 9th days, persisting until the end of the experiment. Our data demonstrates that the effect of aminoguanidine appears to sustain the CXCL12 mRNA synthesis in hematopoietic tissues of irradiated mice, providing some evidences that the axis iNOS -NO - inflammation must be involved in stem cell death, aside to the direct radiation effect, suggesting

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    quence of the principle that a system in thermodynamic equilib- ... pute analog solutions to mathematical problems which require the minimization .... [4] M Zemansky and R Dittman, Heat and Thermodynamics, 8th ed., McGraw. Hill, 2011. [5] Lord Rayleigh, On the Instability of Jets, Proc. Lond. Math. Soc., Vol.10, p.4,. 1878.

  19. Distribution of Th-230 and Th-228 in food (I)

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hee Dong; Kim, Wan; Lim, X. J.; Choi, M. S.; Kim, C. J.; Zheng, Y. Z. [Kyungpook National Univ., Daegu (Korea, Republic of); Kim, Do Sung [Daegu Univ., Daegu (Korea, Republic of)

    2003-03-15

    Natural radioisotopes contained in foods can enter the human body by ingestion and contribute to internal doses to the population. It is necessary to measure the concentration of natural radioisotopes especially thorium in Korean foods and estimate the internal doses. In this study, we have established the thorium measuring process based on the thorium extraction chemical process and alpha spectroscopic method. The concentration of Th-228, Th-230 and Th-232 in Korean milk, meats(pork, beef and chicken) and grain (wheat, bean and rice) are measured and internal doses are estimated.

  20. 15th International Symposium of Robotic Research

    CERN Document Server

    Khatib, Oussama

    2017-01-01

    This volume presents a collection of papers presented at the 15th International Symposium of Robotic Research (ISRR). ISRR is the biennial meeting of the International Foundation of Robotic Research (IFRR) and its 15th edition took place in Flagstaff, Arizona on December 9 to December 12, 2011. As for the previous symposia, ISRR 2011 followed up on the successful concept of a mixture of invited contributions and open submissions. Therefore approximately half of the 37 contributions were invited contributions from outstanding researchers selected by the IFRR officers and the program committee, and the other half were chosen among the open submissions after peer review. This selection process resulted in a truly excellent technical program which featured some of the very best of robotic research. The program was organized around oral presentation in a single-track format and included for the first time a small number of interactive presentations. The symposium contributions contained in this volume report on a ...

  1. Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model.

    Science.gov (United States)

    Zhang, Wenchao; Pan, Yanlong; Gou, Panhong; Zhou, Cheng; Ma, Lianqing; Liu, Qiming; Du, Yuping; Yang, Jinbo; Wang, Qin

    2018-01-01

    Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous studies have reported that XN inhibits the growth of many types of cancer cells, but the effects of XN on tumor immunity have not yet been studied. We explored the effect of XN on Th1/Th2 balance and the underlying mechanism based on a BALB/c-4T1 breast cancer mouse model. The results showed that XN significantly slowed down tumor growth and inhibited expression of antitumor proliferation protein Ki-67 as well as breast cancer-specific marker cancer antigen 15-3 (CA15-3). Flow cytometric analysis revealed that XN enhanced the secretion of perforin, granzyme B and increased the ratio of CD8+/CD25+. ELISA analysis of cytokine results demonstrated that XN obviously upregulated Th1 cytokines, while downregulated Th2 cytokines. Th1/Th2 ratio analysis by flow cytometry illustrated that XN regulated the balance drift to Th1 polarization. Western blotting and immunohistochemistry (IHC) results manifested that XN induced expression of T-bet, a Th1-specific transcription factor. Furthermore, we found that XN significantly promoted the phosphorylation of signal transducer and activator of transcription (STAT)4. Our results demonstrated that XN promoted Th1/Th2 balance towards Th1 polarization, and STAT4 may play a positive role in the regulation of Th1/Th2 cytokines by XN.

  2. Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice.

    Directory of Open Access Journals (Sweden)

    Gordon D Ross

    2007-06-01

    Full Text Available Beta (1-3-D-glucans were identified almost 40 years ago as biological response modifiers that stimulated tumor rejection. In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3, or to, more recently described dectin-1 a beta-glucan specific receptor, acting mainly on phagocytic cells. In this study, we assessed the intracellular cytokine profiles of peripheral blood lymphocytes from mice bearing mammary tumors receiving i.v. anti-tumor mAbs combined or not with whole glucan particle suspension given orally (WGP, 400 microg every 24 hours. The proportions of T cells producing IL-4 and IFNgamma were determined by flow cytometry. The proportion of T cells producing IL-4 was significantly higher in tumor-bearing mice not receiving beta-glucan-enhanced therapy. Conversely, T cells from mice undergoing beta-glucan-enhanced therapy showed increased production of the Th1 cytokine IFNgamma. The switch from a Th2 to a Th1 response after WGP therapy was possibly mediated by intestinal mucosal macrophages releasing IL-12.

  3. Radiation-induced decrease of CD8+ dendritic cells contributes to Th1/Th2 shift.

    Science.gov (United States)

    Liu, Hu; Li, Bailong; Jia, Xiaojing; Ma, Yan; Gu, Yifeng; Zhang, Pei; Wei, Qun; Cai, Jianming; Cui, Jianguo; Gao, Fu; Yang, Yanyong

    2017-05-01

    Exposure to ionizing radiation (IR) often reduce the helper T (Th) 1 like function, resulting in a Th1/Th2 imbalance, which could affect the efficacy of cancer radiotherapy. As the most potent antigen presenting cells, dendritic cells (DC) can be divided into several subsets with specialized function. However, there is no literature covering the changes of DC subsets and their roles in immune regulation in response to IR. In the present study, we were aimed to investigate the changes of DC subsets after IR and its relationship with Th1/Th2 immunity. We found a significant decrease of BDCA3+DC in the blood of patients treated with radiotherapy. CD8+DC, a mouse equivalent of human BDCA3+DC, was also found decreased in mice spleen, peripheral blood and lymph node tissues after irradiation. As CD8+DC mainly induce Th1 immunity, we tested the changes of Th1/Th2 response and found that IR caused a repression of Th1 immunity, indicating a possible role of CD8+DC in radiation-induced Th1/Th2 imbalance. We also found that a CD8+DC-inducing cytokine, Fms-like tyrosine kinase 3 ligand (FLT3 ligand), restored CD8+DC and reversed Th1/Th2 shift. And then we found that bone marrow cells from irradiated mice differentiated into less CD8+DC, which was also protected by FLT3 ligand. In conclusion, our data showed that IR induced a decrease of CD8+DC and Th1/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression. Copyright © 2017. Published by Elsevier B.V.

  4. Th1, Th17, CXCL16 and homocysteine elevated after intracranial and cervical stent implantation.

    Science.gov (United States)

    Tang, Yanyan; Wei, Yunfei; Ye, Ziming; Qin, Chao

    2017-08-01

    The presence of Th1 and Th17 cells has been observed as major inducers in inflammation and immune responses associated stenting. However, there is rare data on the impact of Th1, Th17, CXCL16 and homocysteine after cerebral stent implantation. Here, we performed the statistical analysis to first evaluate the variation of the Th17and Th1 cells and their related cytokines, CXCL16 and homocysteine in the peripheral blood of patients with cerebral stenting. The flow cytometry was used to detect the proportion of Th1 and Th17 cells in peripheral blood mononuclear cells (PBMCs). The enzyme-linked immunosorbent assay was used to measure the serum concentrations of IFN-γ, IL-17 and CXCL16. Plasma homocysteine was examined by immunoturbidimetry. The level of Th1, CXCL16 and homocysteine showed an increase at 3 d, followed by the continuous decrease at 7 d and 3 months. The frequency of Th17 cells increased to a peak at three days, and subsequently decreased with a higher level than baseline. Our data revealed that the variation in Th1, Th17, CXCL16 and homocysteine in peripheral blood of patients with stenting may be implicated in inflammation after intracranial and cervical stent implantation. A better understanding of these factors will provide help for further drug design and clinical therapy.

  5. Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

    Directory of Open Access Journals (Sweden)

    M. Sambucci

    2013-01-01

    Full Text Available T cell differentiation to effector Th cells such as Th1 and Th2 requires the integration of multiple synergic and antagonist signals. Poly(ADP-ribosylation is a posttranslational modification of proteins catalyzed by Poly(ADP-ribose polymerases (PARPs. Recently, many reports showed that PARP-1, the prototypical member of the PARP family, plays a role in immune/inflammatory responses. Consistently, its enzymatic inhibition confers protection in several models of immune-mediated diseases, mainly through an inhibitory effect on NF-κB (and NFAT activation. PARP-1 regulates cell functions in many types of immune cells, including dendritic cells, macrophages, and T and B lymphocytes. Our results show that PARP-1KO cells displayed a reduced ability to differentiate in Th2 cells. Under both nonskewing and Th2-polarizing conditions, naïve CD4 cells from PARP-1KO mice generated a reduced frequency of IL-4+ cells, produced less IL-5, and expressed GATA-3 at lower levels compared with cells from wild type mice. Conversely, PARP-1 deficiency did not substantially affect differentiation to Th1 cells. Indeed, the frequency of IFN-γ+ cells as well as IFN-γ production, in nonskewing and Th1-polarizing conditions, was not affected by PARP-1 gene ablation. These findings demonstrate that PARP-1 plays a relevant role in Th2 cell differentiation and it might be a target to be exploited for the modulation of Th2-dependent immune-mediated diseases.

  6. Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

    Science.gov (United States)

    Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza; Knier, Benjamin; Toft-Hansen, Henrik; Gudi, Viktoria; Floess, Stefan; Huehn, Jochen; Owens, Trevor; Korn, Thomas; Stangel, Martin

    2017-10-16

    Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS. To understand the effects driven by Th17 cells in the CNS, we induced experimental autoimmune encephalomyelitis in wild-type mice and CD4 + T cell-specific integrin α4-deficient mice where trafficking of Th1 cells into the CNS was affected. We compared microglial and astrocyte response in the brain and spinal cord of these mice. We further treated astrocytes with supernatants from highly pure Th1 and Th17 cultures and assessed the messenger RNA expression of neurotrophic factors, cytokines and chemokines, using real-time PCR. Data obtained was analyzed using the Kruskal-Wallis test. We observed in α4-deficient mice weak microglial activation but comparable astrogliosis to that of wild-type mice in the regions of the brain populated with Th17 infiltrates, suggesting that Th17 cells target astrocytes and not microglia. In vitro, in response to supernatants from Th1 and Th17 cultures, astrocytes showed altered expression of neurotrophic factors, pro-inflammatory cytokines and chemokines. Furthermore, increased expression of chemokines in Th1- and Th17-treated astrocytes enhanced recruitment of microglia and transendothelial migration of Th17 cells in vitro. Our results demonstrate the delicate interaction between T cell subsets and glial cells and how they communicate to mediate their effects. Effectors of Th1 act on both microglia and astrocytes whereas Th17 effectors preferentially target astrocytes to promote neuroinflammation.

  7. Cloning and Characterization of ThSHRs and ThSCR Transcription Factors in Taxodium Hybrid 'Zhongshanshan 406'.

    Science.gov (United States)

    Wang, Zhiquan; Yin, Yunlong; Hua, Jianfeng; Fan, Wencai; Yu, Chaoguang; Xuan, Lei; Yu, Fangyuan

    2017-07-20

    Among the GRAS family of transcription factors, SHORT ROOT (SHR) and SCARECROW (SCR) are key regulators of the formation of root tissues. In this study, we isolated and characterized two genes encoding SHR proteins and one gene encoding an SCR protein: ThSHR1 (Accession Number MF045148), ThSHR2 (Accession Number MF045149) and ThSCR (Accession Number MF045152) in the adventitious roots of Taxodium hybrid 'Zhongshanshan'. Gene structure analysis indicated that ThSHR1 , ThSHR2 and ThSCR are all intron free. Multiple protein sequence alignments showed that each of the corresponding proteins, ThSHR1, ThSHR2 and ThSCR, contained five well-conserved domains: leucine heptad repeat I (LHRI), the VHIID motif, leucine heptad repeat II (LHR II), the PFYRE motif, and the SAW motif. The phylogenetic analysis indicated that ThSCR was positioned in the SCR clade with the SCR proteins from eight other species, while ThSHR1 and ThSHR2 were positioned in the SHR clade with the SHR proteins from six other species. Temporal expression patterns of these genes were profiled during the process of adventitious root development on stem cuttings. Whereas expression of both ThSHR2 and ThSCR increased up to primary root formation before declining, that of ThSHR1 increased steadily throughout adventitious root formation. Subcellular localization studies in transgenic poplar protoplasts revealed that ThSHR1, ThSHR2 and ThSCR were localized in the nucleus. Collectively, these results suggest that the three genes encode Taxodium GRAS family transcription factors, and the findings contribute to improving our understanding of the expression and function of SHR and SCR during adventitious root production, which may then be manipulated to achieve high rates of asexual propagation of valuable tree species.

  8. Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance

    Science.gov (United States)

    Martino, Matteo; Rocchi, Giulio; Escelsior, Andrea; Fornaro, Michele

    2012-01-01

    Neurotransmitters and hormones regulate major immune functions, including the selection of T helper (Th)1 or Th2 cytokine responses, related to cell-mediated and humoral immunity, respectively. A role of imbalance and dynamic switching of Th1/Th2 system has been proposed, with relative displacement of the immune reserve in relation to complex interaction between Th1/Th2 and neuro-hormonal balance fluctuations, in the pathogenesis of various chronic human diseases, probably also including psychiatric disorders. Components of the stress system such as norepinephrine (NE) and glucocorticoids appear to mediate a Th2 shift, while serotonin (5-HT) and melatonin might mediate a Th1 shift. Some antidepressants would occur affecting these systems, acting on neurotransmitter balance (especially the 5-HT/NE balance) and expression levels of receptor subtypes, which in turn affect cytokine production and relative Th1/Th2 balance. It could be therefore hypothesized that the antidepressant-related increase in NE tone enhances the Th2 response, while the decrease in NE tone or the increase in 5-HT tone enhances the Th1 response. However, the neurotransmitter and Th1/Th2 balance modulation could be relative, aiming to restore physiological levels a previous imbalance in receptor sensitivity and cytokine production. The considerations on neuro-immunomodulation could represent an additional aid in the study of pathophysiology of psychiatric disorders and in the choice of specific antidepressants in specific clusters of symptoms, especially in comorbidity with internal pathologies. Furthermore limited data, reviewed here, have shown the effectiveness of some antidepressants as pure immunomodulators. However, these considerations are tentative and require experimental confirmation or refutation by future studies. PMID:23204981

  9. Slovenian facsimile in the19th and in the first half of the 20th century:pre-modern facsimile

    Directory of Open Access Journals (Sweden)

    Mihael Glavan

    2004-01-01

    Full Text Available Printers on Slovenian territory did not attempt to print facsimiles until the beginning of the 20th century and neither did they publish anything relevant in this expert field. The development of Slovenian facsimile nevertheless started (outside Slovenia almost a whole century earlier. Its course is outlined against European parallels, providing achievements in the pre-modern era (18129-1959. The analysis focuses on earlier Slovenian facsimiles which have not been well known or had been especially scientifically unexplored. A surprisingly high expert level, both in terms of technology and editing, is revealed by our first facsimiles of the 19th century which were mostly initiated by Jernej Kopitar. In this period medieval materials give way to modern ones (Prešeren’s Poezije, which prevail afterwards. According to the fundamental criteria, upon which the definition of a modern facsimile is based, 12 units have been identified as facsimiles, 4 of them recognised as complete facsimiles meeting all the required criteria of that period.

  10. IL-1β promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes1

    Science.gov (United States)

    Duhen, Thomas; Campbell, Daniel J

    2014-01-01

    In humans, Th1/17 cells, identified by co-expression of the chemokine receptors CCR6 and CXCR3, have been proposed to be highly pathogenic in several autoimmune disorders due in part to their expression of the pro-inflammatory cytokines IL-17, IFN-γ and GM-CSF. However, their developmental requirements, relationship with “classic” Th17 and Th1 cells and physiological role in normal immune responses are not well understood. Here, we examined CCR6+CXCR3+ Th1/17 cells from healthy individuals, and found that ex vivo those cells produced the effector cytokines IL-17, IL-22 and IFN-γ in all possible combinations, and were highly responsive to both IL-12 and IL-23. Moreover, although the antigen specificity of CCR6+CXCR3+ Th1/17 cells showed substantial overlap with that of Th1 and Th17 cells, this population was enriched in cells recognizing certain extracellular bacteria and expressing the intestinal homing receptor integrin β7. Finally, we identified IL-1β as a key cytokine that renders Th17 cells sensitive to IL-12, and both cytokines together potently induced the differentiation of cells that produce IL-17, IFN-γ and GM-CSF. Therefore, interfering with IL-1β and IL-12 signaling in Th17 cells during inflammation may be a promising therapeutic approach to reduce their differentiation into “pathogenic” CCR6+CXCR3+ Th1/17 cells in patients with autoimmune diseases. PMID:24890729

  11. Selected Lectures of the 13th International Workshop on Neonatology; Cagliari (Italy); October 25th-28th, 2017

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Lectures of the 13th International Workshop on Neonatology • The power of Epigenetics • Twins: identical but different • Cagliari (Italy) • October 25th-28th, 2017LECT 1. ASPHYXIA IN THE THIRD MILLENNIUM: FROM VIRGINIA APGAR TO METABOLOMICS • O.D. SaugstadLECT 2. INTRAPARTUM FETAL MONITORING: WHERE ARE WE NOW? • D. Ayres-de-CamposLECT 3. THERAPEUTIC HYPOTHERMIA: REVISED IN­DI­CA­TIONS • E. SalibaLECT 4. ANTIBIOTICS PRESCRIPTION IN NEONATAL INTENSIVE CARE UNIT • G. DimitriouLECT 5. CH...

  12. Modeling of oxygen incorporation in Th, ThC, and ThN by density functional theory calculations

    Science.gov (United States)

    Pérez Daroca, D.; Llois, A. M.; Mosca, H. O.

    2017-12-01

    Oxygen incorporation in nuclear fuel materials is an important issue deserving investigation due to its influence on thermophysical and structural properties. Even if there has been a renewed interest in thorium and thorium compounds in the last years, there is still not much research done on this topic. In this work, we study, by means of density functional theory calculations, the incorporation of oxygen in Th, ThC, and ThN. We analyze the electronic structure finding a characteristic peak to be attributed to oxygen incorporation. We also calculate incorporation and solution energies and obtain migration energies of oxygen through different paths finding that migration through vacancy sites is more energetically favorable than through interstitial ones.

  13. Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease.

    Science.gov (United States)

    Imperatore, Nicola; Rispo, Antonio; Capone, Pietro; Donetto, Sara; De Palma, Giovanni Domenico; Gerbino, Nicolò; Rea, Matilde; Caporaso, Nicola; Tortora, Raffaella

    2016-07-01

    Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). To evaluate: (1) the prevalence of IMD at the time of and after CD diagnosis; (2) a possible change in immune response to gluten free diet (GFD); (3) the potential role of GFD in reducing and/or preventing IMD in CD. Prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p=0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant "switch" from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p<0.01; OR 1.9). The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  14. Climate and history in the late 18th and early 19th centuries

    Science.gov (United States)

    Feldman, Theodore S.

    As in many areas of human knowledge, the notion of climate acquired a deeper historical content around the turn of the 19th century. Natural philosophers, geographers, and others became increasingly aware of climate's own history and its relation to human, plant and animal, and Earth history. This article examines several aspects of this “historicization” of climate.The lively 18th century discussion of the influence of climate on society is well known. Montesquieu is its most famous representative, but Voltaire, Hume, Kant, and others also participated. Their debate was literary more than scientific, their goal the understanding of man, not climate. Partly for this reason and partly because of the lack of good information on climates, they made no attempt to gather substantial climatic data. In fact, the importance of systematically collecting reliable data was scarcely understood in any area of natural philosophy before the last decades of the century [Cf. Frängsmyr et al., 1990; Feldman, 1990]. Instead, participants in the debate repeated commonplaces dating from Aristotle and Hippocrates and based their conclusions on unreliable reports from travelers. As Glacken wrote of Montesquieu, “his dishes are from old and well-tested recipes” [Glacken, 1967, chapter 12]. This is not to say that the debate over climatic influence was not significant—only that its significance lay more in the history of man than in the atmospheric sciences.

  15. Association of Grade Configuration with School Climate for 7th and 8th Grade Students

    Science.gov (United States)

    Malone, Marisa; Cornell, Dewey; Shukla, Kathan

    2017-01-01

    Educational authorities have questioned whether middle schools provide the best school climate for 7th and 8th grade students, and proposed that other grade configurations such as K-8th grade schools may provide a better learning environment. The purpose of this study was to compare 7th and 8th grade students' perceptions of 4 key features of…

  16. Invitation to the 17th international congress on photosynthesis research in 2016

    NARCIS (Netherlands)

    Amerongen, van Herbert; Croce, Roberta

    2016-01-01

    The 17th International Congress on Photosynthesis will be held from August 7 to 12, 2016 in Maastricht, The Netherlands. The congress will include an opening reception, 15 plenary lectures, 28 scientific symposia, many poster sessions, displays by scientific companies, excursions, congress

  17. Effects of γ-rays on Th1 and Th2 immune function of mice

    International Nuclear Information System (INIS)

    Jin Wei; Cui Yufang; An Xiaoxia; Xu Han; Dong Bo; Liu Xiaolan; Luo Qingliang

    2007-01-01

    Objective: To observe the effects of 6 Gy whole body γ-irradiation on immune function of Th1 and Th2 in mouse, and to investigate the cellular and molecular mechanism of immune system injury induced by irradiation. Methods: Surface marker and intracellular cytokines of lymphocytes were stained with fluorescence-labeled monoclonal antibodies, then the changes of lymphocyte subpopulations, especially the Th1 and Th2 in mouse peripheral blood and spleen were analyzed by flow cytometry. Results: (1) 1 d after 6 Gy y- irradiation, lymphocytic subsets of CD 19 + and CD 8 + in spleen decreased apparently and the percentages of them were only 30% and 41% of control groups respectively (P 19 + and 14 d for CD 8 + respectively, however, up to 21 d post-irradiation they still did not return to control level. (2) Th1 subpopulations in mouse peripheral blood and spleen were significantly reduced at 1 d after irradiation and were only 2.6% and 7.6% of control groups (P 4 + / CD 8 + were significantly increased at 1 d post-irradiation in mouse spleen because of swift reduction of CD 8 + cells. Interestingly, either in peripheral blood or in spleen in irradiated mice, the ratio of Th1/Th2 were evidently raised because of the decrement of Th1 cells, exhibited obviously a phenomenon of predominant immune response of Th2 cells. Conclusions: It is suggested that the depression of mouse immune function induced by 6 Gy γ-irradiation might be caused by changes of CD 4 + /CD 8 + ratio, especially the imbalance of Th1/Th2 function subpopulations. It is shown that the imbalance of Th1/Th2 function subpopulations plays an important role in radiation-induced immune injury, thus providing a better insight into the molecular mechanism and new strategies for prevent and treatment measures of immune injury by irradiation. (authors)

  18. Determination of thermo-physical properties of (Th,Ce)O2 MOX using classical molecular dynamics simulations

    International Nuclear Information System (INIS)

    Ghosh, P.S.; Arya, A.; Dey, G.K.; Somayajulu, P.S.

    2015-01-01

    This paper calculates lattice thermal expansion (LTE) and thermal conductivity (TC) of Th 1-x Ce x O 2 (x=0.0, 0.0625 and 0.125) MOX using classical molecular dynamic simulations. The potential parameters of Coulomb-Buckingham function for Th-O, Ce-O and O-O were determined by fitting experimentally available LTE data for pure ThO 2 and CeO 2 . The calculated linear thermal expansion coefficients in the temperature range 300-1500K for ThO 2 , CeO 2 , Th 93.75 Ce 6.25 O 2 and Th 87.5 Ce 12.5 O 2 are 10.61, 13.08, 10.78 and 10.93x10 -6 K -1 , respectively. The MD calculated LTE values of ThO 2 and (Th,Ce)O 2 MOX are slightly higher than the experimentally determined values. The MD calculated TC values of ThO 2 and (Th,Ce)O 2 MOX in the high temperature range (600 to 1200 K) our results accords very well with the experimental measurements and at the low temperature range (300-500 K) our results are slightly different from some experimental results as the difference comes from our presumption that the dominant mechanism for phonon scattering is the Umklapp process. (author)

  19. Distribution of Th-230 and Th-228 in foods(II)

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hee Dong; Kim, Wan; Lim, S. K.; Lee, S. A.; Choi, M. S.; Zheng, Y. C. [Kyungpook National Univ., Daegu (Korea, Republic of); Kim, Do Sung [Daegu Univ., Daegu (Korea, Republic of)

    2004-02-15

    Natural radioisotopes contained in foods can enter the human body by ingestion and contribute to internal doses to the population. It is necessary to measure the concentration of natural radioisotopes especially thorium in Korean foods and estimate the internal doses. In this study, we have established the thorium measuring process based on the thorium extraction chemical process and alpha spectroscopic method. The concentration of Th-228, Th-230 and Th-232 in Korean vegetables (potato, sweet potato, radish, cabbage, hot pepper, garlic, onion and pumpkin) and fruits(apple, persimmon, orange, pear, grape) are measured and their internal doses are estimated.

  20. Distribution of Th-230 and Th-228 in foods(II)

    International Nuclear Information System (INIS)

    Kang, Hee Dong; Kim, Wan; Lim, S. K.; Lee, S. A.; Choi, M. S.; Zheng, Y. C.; Kim, Do Sung

    2004-02-01

    Natural radioisotopes contained in foods can enter the human body by ingestion and contribute to internal doses to the population. It is necessary to measure the concentration of natural radioisotopes especially thorium in Korean foods and estimate the internal doses. In this study, we have established the thorium measuring process based on the thorium extraction chemical process and alpha spectroscopic method. The concentration of Th-228, Th-230 and Th-232 in Korean vegetables (potato, sweet potato, radish, cabbage, hot pepper, garlic, onion and pumpkin) and fruits(apple, persimmon, orange, pear, grape) are measured and their internal doses are estimated

  1. Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney.

    Science.gov (United States)

    Nastase, Madalina-Viviana; Zeng-Brouwers, Jinyang; Beckmann, Janet; Tredup, Claudia; Christen, Urs; Radeke, Heinfried H; Wygrecka, Malgorzata; Schaefer, Liliana

    2017-12-15

    Th1 and Th17 cells, T helper (Th) subtypes, are key inducers of renal fibrosis. The molecular mechanisms of their recruitment into the kidney, however, are not well understood. Here, we show that biglycan, a proteoglycan of the extracellular matrix, acting in its soluble form as a danger signal, stimulates autonomously the production of Th1 and Th17 chemoattractants CXCL10 and CCL20 in macrophages. In the presence of IFNγ, biglycan synergistically stimulates CXCL9. In macrophages deficient for TLR2, TLR4, and their adaptor molecules MyD88 or TRIF, we identified highly selective mechanisms of biglycan-dependent Th1/17 chemoattraction. Thus, the expression of CXCL9 and CXCL10, common chemoattractants for CXCR3-positive Th1 and Th17 cells, is triggered in a biglycan-TLR4/TRIF-dependent manner. By contrast, biglycan induces CCL20 chemokine production, responsible for CCR6-positive Th17 cell recruitment, in a TLR2/4/MyD88-dependent manner. Importantly, at the onset of diabetes mellitus and lupus nephritis we provide evidence for biglycan-dependent recruitment of Th1 and Th17 cells, IFNγ and IL-17 production, and development of albuminuria in mice lacking or overexpressing soluble biglycan. Furthermore, by genetic ablation of Cxcl10 we showed in vivo involvement of this chemokine in biglycan-dependent recruitment of Th1 and Th17 cells into the kidney. Finally, a positive correlation of biglycan and CXCL10/CXCL9 levels was detected in plasma from patients with diabetic nephropathy and lupus nephritis. Taken together, we identified biglycan as a novel trigger of Th1 and Th17 cell recruitment into the kidney and we postulate that interfering with biglycan/TLR/TRIF/MyD88-signaling might provide novel therapeutic avenues for renal fibrosis. Copyright © 2017 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

  2. Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients.

    Science.gov (United States)

    Nasr, Amre; Abushouk, Amir; Hamza, Anhar; Siddig, Emmanuel; Fahal, Ahmed H

    2016-07-01

    Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this study is to determine the levels of Th-1 and Th-2 cytokines in patients infected with Madurella mycetomatis, and the association between their levels and disease prognosis. This is a descriptive cross-sectional study conducted at the Mycetoma Research Centre, University of Khartoum, Sudan, where 70 patients with confirmed M. mycetomatis eumycetoma were enrolled; 35 with, and 35 without surgical excision. 70 healthy individuals from mycetoma endemic areas were selected as controls. The levels of serum cytokines were determined by cytometric bead array technique. Significantly higher levels of the Th-1 cytokines (IFN-γ, TNF-α, IL-1β and IL-2) were recorded in patients treated with surgical excision, compared to those treated without surgical excision. In contrast, the Th-2 cytokines (IL-4, IL-5, IL-6 and IL-10) were significantly lower in patients treated with surgical excision compared to those treated without surgical excision. In conclusion, the results of this study suggest that cell-mediated immunity can have a role to play in the pathogenesis of eumycetoma.

  3. 40th Plenary Meeting Report of the Scientific, Technical and Economic Committee for Fisheries (PLEN-12-02)

    DEFF Research Database (Denmark)

    Abella, J. A.; Andersen, J.; Bailey, N.

    The Scientific, Technical and Economic Committee for Fisheries hold its 40th plenary on 9-13 July 2012 in Copenhagen (Denmark). The terms of reference included both issues assessments of STECF Expert Working Group reports and additional requests submitted to the STECF by the Commission. Topics...

  4. 39th Plenary Meeting Report of the Scientific, Technical and Economic Committee for Fisheries (PLEN-12-01)

    DEFF Research Database (Denmark)

    Abella, J. A.; Andersen, J.; Bailey, N.

    The Scientific, Technical and Economic Committee for Fisheries hold its 39th plenary on 16-20 April 2012 in Brussels (Belgium). The terms of reference included both issues assessments of STECF Expert Working Group reports and additional requests submitted to the STECF by the Commission. Topics...

  5. Percutaneous coronary intervention for the left main stem and other bifurcation lesions: 12th consensus document from the European Bifurcation Club.

    Science.gov (United States)

    Lassen, Jens Flensted; Burzotta, Francesco; Banning, Adrian P; Lefèvre, Thierry; Darremont, Olivier; Hildick-Smith, David; Chieffo, Alaide; Pan, Manuel; Holm, Niels Ramsing; Louvard, Yves; Stankovic, Goran

    2018-01-20

    The European Bifurcation Club (EBC) was initiated in 2004 to support a continuous overview of the field of coronary artery bifurcation interventions and aims to facilitate a scientific discussion and an exchange of ideas on the management of bifurcation disease. The EBC hosts an annual, two-day compact meeting, dedicated to bifurcations, which brings together physicians, pathologists, engineers, biologists, physicists, mathematicians, epidemiologists and statisticians for detailed discussions. Every meeting is finalised with a consensus statement that reflects the unique opportunity of combining the opinion of interventional cardiologists with the opinion of a large variety of other scientists on bifurcation management. A series of consensus sessions dedicated to specific topics, to strengthen the consensus debates and focus the discussions, was introduced at this year's meeting. The sessions comprise an intensive overview of the present literature, a pro and con debate and a voting system, to guide the consensus-building process. The present document represents the summary of the up-to-date EBC consensus and recommendations from the 12th annual EBC meeting in 2016 in Rotterdam.

  6. TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression.

    Science.gov (United States)

    Liu, Hou-Pu; Cao, Anthony T; Feng, Ting; Li, Qingjie; Zhang, Wenbo; Yao, Suxia; Dann, Sara M; Elson, Charles O; Cong, Yingzi

    2015-04-01

    Differentiated CD4(+) T cells preserve plasticity under various conditions. However, the stability of Th1 cells is unclear, as is whether Th1 cells can convert into Th17 cells and thereby contribute to the generation of IFN-γ(+) IL-17(+) CD4(+) T cells, the number of which correlates with severity of colitis. We investigated whether IFN-γ(+) Th1 cells can convert into Th17 cells under intestinal inflammation and the mechanisms involved. IFN-γ(Thy1.1+) Th1 cells were generated by culturing naïve CD4(+) T cells from IFN-γ(Thy1.1) CBir1 TCR-Tg reporter mice, whose TCR is specific for an immunodominant microbiota antigen, CBir1 flagellin, under Th1 polarizing conditions. IFN-γ(Thy1.1+) Th1 cells induced colitis in Rag(-/-) mice after adoptive transfer and converted into IL-17(+) Th17, but not Foxp3(+) Treg cells in the inflamed intestines. TGF-β and IL-6, but not IL-1β and IL-23, regulated Th1 conversion into Th17 cells. TGF-β induction of transcriptional factor Runx1 is crucial for the conversion, since silencing Runx1 by siRNA inhibited Th1 conversion into Th17 cells. Furthermore, TGF-β enhanced histone H3K9 acetylation but inhibited H3K9 trimethylation of Runx1- and ROR-γt-binding sites on il-17 or rorc gene in Th1 cells. We conclude that Th1 cells convert into Th17 cells under inflammatory conditions in intestines, which is possibly mediated by TGF-β induction of Runx1. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. 77 FR 21773 - Filing Dates for The New Jersey Special Election in The 10th Congressional District

    Science.gov (United States)

    2012-04-11

    ... The 10th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates... with both the Special Primary and Special General Election on November 6, 2012, shall file a 12-day Pre... General Elections shall file a 12-day Pre-Primary Report on May 24, 2012; a 12-day Pre-General Report on...

  8. ONR Tokyo Scientific Bulletin. Volume 4, Number 4, October-December 1979,

    Science.gov (United States)

    1979-12-01

    myotonic dystrophy, myxeodema, obesity , Parkinson’s disease, epilepsy, alcoholism, schizophrenia, rheumatoid arthritis, tetanus, acromegaly, depression...12 12 Iraq 2,000 8 7 Korea 2,000 84 26 Malaysia 3,000 5 5 Phillipines 5,000 18 10 Singapore 1,000 2 2 Sri Lanka 7,000 7 7 Thailand 2,000 18 10...previously in the Bulletin. MALAYSIA Chemistry research in Malaysian universities is mainly in the areas of applications such as natural products

  9. The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice.

    Directory of Open Access Journals (Sweden)

    Kuo-Liang Huang

    Full Text Available Particulate matter (PM has been associated with increased pulmonary and cardiovascular mortality and morbidity. Additionally, PM is known to exacerbate asthma. However, whether ambient PM exposure contributes to the onset of asthma, especially in non-atopic children and adults, is less conclusive. The current study aimed to evaluate the effects of size-fractioned PM on lung immune responses in healthy BALB/c mice.We collected PM10, PM2.5, PM1 and PM0.1 samples from October 2012 to August 2013 in the Taipei Basin. These PM samples were representative of urban traffic pollution. The samples were extracted and sonicated in phosphate-buffered saline (PBS. Female BALB/c mice were exposed to the samples via intratracheal instillation at three different doses: 1.75 mg/kg (35 μg/per mouse, 5 mg/kg (100 μg/per mouse, and 12.5 mg/kg (250 μg/per mouse. The mice were exposed on days 0 and 7, and PBS alone was used as a control. Following the exposures, the expression profiles of inflammatory cells and cytokines in bronchoalveolar lavage fluid (BALF were assessed. Exposure to PM10 resulted in inflammatory responses, including the recruitment of neutrophils and the induction of T helper 1 (Th1 cell-related cytokine release, such as TNF-α and IFN-γ. Furthermore, an allergic immune response, including the recruitment of eosinophils and the up-regulation of T helper 2 (Th2 cell-related cytokine release, such as IL-5 and IL-13, was also observed in the BALF of mice exposed to PM10.Our study showed that exposure to PM alone caused mixed Th1/Th2 inflammatory responses in healthy mice. These findings support the hypothesis that PM may contribute to the onset of asthma.

  10. Pima Community College Planning Grant for Autonomous Intelligent Network of Systems (AINS) Science, Mathematics and Engineering Education Center

    National Research Council Canada - National Science Library

    2006-01-01

    .... The Center was to be funded by the Department of Defense, Office of Naval Research (ONR). The TDRI AINS Center's objectives were to advance ONR's technologies and to improve exposure and participation in science, math, and engineering (SME...

  11. Citrus tachibana Leaves Ethanol Extract Alleviates Airway Inflammation by the Modulation of Th1/Th2 Imbalance via Inhibiting NF-κB Signaling and Histamine Secretion in a Mouse Model of Allergic Asthma.

    Science.gov (United States)

    Bui, Thi Tho; Piao, Chun Hua; Kim, Soo Mi; Song, Chang Ho; Shin, Hee Soon; Lee, Chang-Hyun; Chai, Ok Hee

    2017-07-01

    Asthma is a chronic inflammatory disease of bronchial airway, which is characterized by chronic airway inflammation, airway edema, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration in the lungs. In this study, the therapeutic effect and the underlying mechanism of Citrus tachibana leaves ethanol extract (CTLE) in the ovalbumin (OVA)-induced allergic asthma and compound 48/80-induced anaphylaxis were investigated. Oral administration of CTLE inhibited OVA-induced asthmatic response by reducing airway inflammation, OVA-specific IgE and IgG1 levels, and increasing OVA-specific IgG2a levels. CTLE restored Th1/Th2 balance through an increase in Th2 cytokines tumor necrosis factor-α, interleukin (IL)-4, and IL-6 and decreases in Th1 cytokines interferon-γ and IL-12. Furthermore, CTLE inhibited the total level of NF-κB and the phosphorylation of IκB-α and NF-κB by OVA. In addition, CTLE dose-dependently inhibited compound 48/80-induced anaphylaxis via blocking histamine secretion from mast cells. The anti-inflammatory mechanism of CTLE may involve the modulation of Th1/Th2 imbalance via inhibiting the NF-κB signaling and histamine secretion. Taken together, we suggest that CTLE could be used as a therapeutic agent for patients with Th2-mediated or histamine-mediated allergic asthma.

  12. USAF Summer Research Program - 1994 Summer Faculty Research Program Final Reports, Volume 5B, Wright Laboratory

    Science.gov (United States)

    1994-12-01

    S.K. Streiffer, B.M. Lairson, E.M. Zielinski , T. Umezawa, T.H. Geballe, and J.C. Bravman, Proc 50th Annual Meefrng of EMSA, edited by G.W. Bailey...Theory team at WL/AART-2: Dave Gadd, Mike Noviskey, Jeff Goldman; and also Chris Vogt, Mark Axtel, John Carroll, and Craig Files, who all contributed to...modification work on the wind tunnel were done by Dave Driscoll at the AFIT shop. We thank him for his steady and careful efforts, especially for the cast

  13. Aberrant Production of Th1/Th2/Th17-Related Cytokines in Serum of C57BL/6 Mice after Short-Term Formaldehyde Exposure

    Directory of Open Access Journals (Sweden)

    Haiyan Wei

    2014-09-01

    Full Text Available Previous studies have shown that formaldehyde (FA could cause immunotoxicity by changing the number of T lymphocytes and that cytokines play a pivotal role in the regulation of T lymphocytes. However, the previously used cytokine detection methods are difficult to use in the measurement of several cytokines in a small amount of sample for one test. Therefore, the cytometric bead array (CBA technique was used. CBA showed better analytical efficiency and sensitivity than the previous methods. C57BL/6 mice were exposed to the control (normal saline, low FA concentration (0.5 mg/kg, and high FA concentration (2 mg/kg for 1 week or 1 month. The contents of cytokines, including Th1-related cytokines (IL-2, IFN-γ, and tumor necrosis factor, Th2-related cytokines (IL-4, IL-6, and IL-10, and Th17-related cytokines (IL-17A, were measured by using the BD FACS Canto II Flow Cytometer and analyzed by FCAP ArrayTM Software. Th1/Th2/Th17-related cytokines showed a slightly decreasing trend after low FA exposure. Conversely, a significantly increasing trend was found after high FA exposure. Th1/Th2/Th17-related cytokines all serve important functions in the immune reactions in mice after FA exposure.

  14. Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization.

    Science.gov (United States)

    Umeyama, Akemi; Yahisa, Yoshinori; Okada, Minori; Okayama, Eriko; Uda, Ayaka; Shoji, Noboru; Lee, Je-Jung; Takei, Masao; Hashimoto, Toshihiro

    2010-10-01

    Dendritic cells (DC) are key antigen-presenting cells that link innate and adaptive immunity and ultimately activate antigen-specific T cells. In the current study, we demonstrated that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC. We also show that 1 and 2 modulate human DC function in a fashion that favors Th1 cell polarization. The effect of 1 (E configuration at the 2' position) was approximately 20 times more potent than that of 2 (Z configuration at 2'). These results indicated that the configuration of the 2' double bond greatly effects activity. Thus, 1 and 2 may prove useful as DC-based vaccines for cancer immunotherapy.

  15. 18th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G

    2014-01-01

    Cryocoolers 18 Cryocoolers 18 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 18th International Cryocooler Conference that was held in Syracuse, New York, on June 9-12, 2014. The program of this conference lead to the 76 peer-reviewed papers that are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  16. 78 FR 68443 - Filing Dates for the Florida Special Elections in the 13th Congressional District

    Science.gov (United States)

    2013-11-14

    ... 13th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for... Primary and the Special General Election on March 11, 2014, shall file a 12-day Pre-Primary Report, 12-day... committees of candidates who participate in the Florida Special Primary and Special General Elections shall...

  17. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.

    Directory of Open Access Journals (Sweden)

    Gaëlle Chognard

    Full Text Available IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of each of these receptors is restricted to specific cell types, in both mouse and human. Indeed, although IL-12Rβ2 is expressed by NK cells and a subset of γδ T cells, the expression of IL-23R is restricted to specific T cell subsets, a small number of B cells and innate lymphoid cells. By exploiting an IL-12- and IL-23-dependent mouse model of innate inflammation, we demonstrate an intricate interplay between IL-12Rβ2 NK cells and IL-23R innate lymphoid cells with respectively dominant roles in the regulation of systemic versus local inflammatory responses. Together, these findings support an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states, which may allow more accurate dissection of the roles of these receptors in chronic inflammatory diseases in humans.

  18. Determination of Sc and Th in ScI3-NaI-ThI4 sample

    International Nuclear Information System (INIS)

    Yuan Hui; Yang Zhihong

    1999-01-01

    Determination of Sc and Th in ScI 3 -NaI-ThI 4 sample is studied by X-ray fluorescence and complexometry. The effect of working condition of Sc on X-ray fluorescence spectrometer and different sample-making method on the determination of Sc and Th are studied experimentally. The X-ray fluorescence analysis of determination of Sc and Th is developed by polyester film sample-making technique, the measuring precision of Sc and Th is better than 4%. The effect of acidity and temperature on the determining end point of titration is obvious. The results of different complexometric methods are compared. The precision of Sc and Th is less than 2% by comlexometry, it is fit for the routine analysis of ScI 3 -NaI-ThI 4 sample

  19. Determination of 230Th/232Th and correct methods by High Resolution Inductively Coupled Plasma Mass Spectrometry

    International Nuclear Information System (INIS)

    Xie Shengkai; Guo Dongfa; Tan Jing; Zhang Yanhui; Huang Qiuhong; Gao Aiguo

    2013-01-01

    It is very important for the rapid and reliable determination of 230 Th/ 232 Th in the thorium-230 dating. A method of measuring 230 Th/ 232 Th in natural samples by high resolution inductively coupled plasma mass spectrometer (HR-ICP-MS) was developed on the base of our former work. The precise and accurate of natural 230 Th in geology samples is challenging, as the peak tailing to the high intensity of neighboring peak at 232 Th and the mass discrimination of the instrument. The peak tailing of 238 U to 236 U was used to decrease the peak tailing effect of 232 Th to 230 Th. The mass discrimination factor K between ture and measured isotope ratio was calculated after measuring different 230 Th/ 232 Th ratio solutions. Lab used standard samples was digested in mixed acids of HN0 3 -HF-HCI-HCl0 4 , and separated by the Bio-rad AG 1 × 8 Cl - resin. The measurement method of blank-standard-blank-sample procession was used to determinate the 230 Th/ 232 Th. The measured result of 230 Th/ 232 Th was at (7.29 ± 0.34) × 10 -6 , which agreed with the reference value of (7.33 ± 0.17) × 10 -6 . (authors)

  20. Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response

    DEFF Research Database (Denmark)

    Moser, C; Jensen, P O; Kobayashi, O

    2002-01-01

    , resistance to re-infection was paralleled by a shift towards a Th1-dominated response and increased IL-12 production. No significant increase in serum IgG was observed in the re-infected mice. In conclusion, these results indicate a protective role for a Th1-dominated response, independent of antibody...

  1. Special issue containing papers presented at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (7-11 September 2011) Special issue containing papers presented at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems (7-11 September 2011)

    Science.gov (United States)

    Berk, H. L.

    2012-09-01

    The topic of the behaviour of energetic alpha particles in magnetic fusion confined plasmas is perhaps the ultimate frontier plasma physics issue that needs to be understood in the quest to achieve controlled power from the fusion reaction in magnetically confined plasmas. The partial pressure of alpha particles in a burning plasma will be ~5-10% of the total pressure and under these conditions the alpha particles may be prone to develop instability through Alfvénic interaction. This may lead, even with moderate alpha particle loss, to a burn quench or severe wall damage. Alternatively, benign Alfvénic signals may allow the vital information to control a fusion burn. The significance of this issue has led to extensive international investigations and a biannual meeting that began in Kyiv in 1989, followed by subsequent meetings in Aspenäs (1991), Trieste (1993), Princeton (1995), JET/Abingdon (1997), Naka (1999), Gothenburg (2001), San Diego (2003), Takayama (2005), Kloster Seeon (2007) and Kyiv (2009). The meeting was initially entitled 'Alpha Particles in Fusion Research' and then was changed during the 1997 meeting to 'Energetic Particles in Magnetic Confinement Systems' in appreciation of the need to study the significance of the electron runaway, which can lead to the production of energetic electrons with energies that can even exceed the energy produced by fusion products. This special issue presents some of the mature interesting work that was reported at the 12th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems, which was held in Austin, Texas, USA (7-11 September 2011). This meeting immediately followed a related meeting, the 5th IAEA Technical Meeting on Theory of Plasma Wave Instabilities (5-7 September 2011). The meetings shared one day (7 September 2011) with presentations relevant to both groups. The presentations from most of the participants, as well as some preliminary versions of papers, are available at the

  2. An Assessment of Binary Metallic Glasses: Correlations Between Structure, Glass Forming Ability and Stability (Preprint)

    Science.gov (United States)

    2011-07-01

    volume (via indentation, relaxation or positron annihilation ) are expected to significantly clarify structural descriptions. Further insights may be... applicability of the concept of smaller spheres filling the interstices of larger spheres diminishes with decreasing difference in size, the efficient...alloys observed by Mossbauer spectroscopy and calorimetry’, Rapidly Quenched Metals, Proc. 4th International Conference on Rapidly Quenched Metals

  3. Fabrication and Benchmarking of a Stratix V FPGA with Monolithic Integrated Microfluidic Cooling

    Science.gov (United States)

    2017-03-01

    on ei any micropin- g with the mic . An SEM im the same proc . on lid was fab e lid was first with high tem ooth surface oard. Afte back side of th...it meets market requirements for Stratix V target applications. The FPGA heat flux is lower than many high power processors and the low profile air

  4. Individual and school level effects of perceived harm, perceived availability, and community size on marijuana use among 12th-grade students: a random effects model.

    Science.gov (United States)

    Swaim, Randall C

    2003-06-01

    A hierarchical linear model was used to estimate the individual and school level effects for marijuana use among a national sample of 12th-grade students. School effects were small in comparison to individual level effects, accounting for 2.9% of the variance in marijuana use. At the individual level, perceived harm, perceived availability, and their interaction were significant predictors, each of which varied randomly across schools. Among two school-level predictors, the normative environment for perceived harm was not significant, but normative perceived availability predicted level of marijuana use. The effect of perceived availability on marijuana use was stronger in larger, compared to smaller communities. Results are discussed in light of the use of random regression methods for identifying school-specific patterns of risk and protection for prevention planning.

  5. Association between Th1/Th2 immune imbalance and obesity in women with or without polycystic ovary syndrome.

    Science.gov (United States)

    Gong, Ping; Shi, Bingwei; Wang, Juan; Cao, Peixia; Diao, Zhenyu; Wang, Yuji; Hu, Yali; Li, Shuping

    2018-02-15

    This study aimed to investigate the Th1/Th2 cells in peripheral blood of PCOS patients, and assess the potential correlation between Th1/Th2 imbalance and obesity. Thirty-nine PCOS patients and 23 age-matched controls were enrolled. The PBMCs were obtained before pharmacological intervention in women with or without PCOS. The profiles of Th1 (IFN-γ) and Th2 (IL-4) cytokines of CD3 + CD - T lymphocyte subsets were analyzed by flow cytometry. Plasma sex hormones including E 2 , T, FSH, LH, and FINS, FPG were measured, together with BMI, WC, LH/FSH, E 2 /T and HOMA-IR index being calculated. Association between Th1/Th2 imbalance and BMI, WC were evaluated. The proportion of Th1 cells and Th1/Th2 ratio were significantly higher in PCOS patients than those in controls, accompanied by elevated T, LH, LH/FSH, FINS, HOMA-IR index and reduced E 2 /T. The Th1/Th2 ratio was increased when BMI and WC were enhanced in PCOS. Moreover, the significant difference of Th1/Th2 ratio was observed between WC subgroups of PCOS. It is concluded that Th1 type immunity is predominant in systemic immunization of PCOS patients. Th1/Th2 immune imbalance is connected with obesity, especially abdominal obesity, and may be one of the underlying mechanism for the pathogenesis of PCOS.

  6. Comparative Analysis of Indicators of Coordination Abilities Development in 5th-7th Graders

    Directory of Open Access Journals (Sweden)

    В. В. Приходько

    2017-09-01

    Full Text Available The objective of the research is to determine the regularities of coordination abilities development in 5th-7th-grade boys.  Materials and methods. The participants in the research were boys of the 5th grade (n = 21, 6th grade (n = 20, 7th grade (n = 19. To achieve the tasks outlined, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, methods of mathematical statistics. Research results. The 5th-6th-grade boys show a statistically significant difference between their results in the following tests: “Standing long jump (cm” (p < 0.002; “Six standing accuracy ball handlings to a partner from a 7 m distance using one of the techniques learned” (p < 0.049; “Rhythmic hand tapping” (p < 0.044; “Rhythmic movements of upper and lower limbs” (p < 0.042 (p < 0.05; “Height (cm”; “Body weight (kg”. The 6th-7th-grade boys — “30 m running (s”; “Standing long jump (cm”; “Sit-ups in 30 seconds”; “Evaluation of static equilibrium by E. Ya. Bondarevsky’s method”; “Evaluation of dynamic equilibrium by the BESS method”; “Rhythmic hand tapping”; “Rhythmic movements of upper and lower limbs”; “Shuttle run (4 × 9 m”; “Tossing rings over a peg”. The 5th-7th-grade boys — “Standing long jump (cm”; “Pull-ups (number of times”; “Evaluation of the ability to differentiate movement speed (accuracy in reproduction of running speed, 90% of maximum”; “Evaluation of static equilibrium by E. Ya. Bondarevsky’s method”; “Evaluation of dynamic equilibrium by the BESS method”; “Rhythmic hand tapping”; “Shuttle run (4 × 9 m”; “Height (cm”; “Body weight (kg”. Conclusions. The research has observed a positive dynamics of the results in the following group of tests: “Standing long jump” by 8.4%, “Rhythmic hand tapping and rhythmic movements of upper and lower

  7. Solar wind control of stratospheric temperatures in Jupiter's auroral regions?

    Science.gov (United States)

    Sinclair, James Andrew; Orton, Glenn; Kasaba, Yasumasa; Sato, Takao M.; Tao, Chihiro; Waite, J. Hunter; Cravens, Thomas; Houston, Stephen; Fletcher, Leigh; Irwin, Patrick; Greathouse, Thomas K.

    2017-10-01

    Auroral emissions are the process through which the interaction of a planet’s atmosphere and its external magnetosphere can be studied. Jupiter exhibits auroral emission at a multitude of wavelengths including the X-ray, ultraviolet and near-infrared. Enhanced emission of CH4 and other stratospheric hydrocarbons is also observed coincident with Jupiter’s shorter-wavelength auroral emission (e.g. Caldwell et al., 1980, Icarus 44, 667-675, Kostiuk et al., 1993, JGR 98, 18823). This indicates that auroral processes modify the thermal structure and composition of the auroral stratosphere. The exact mechanism responsible for this auroral-related heating of the stratosphere has however remained elusive (Sinclair et al., 2017a, Icarus 292, 182-207, Sinclair et al., 2017b, GRL, 44, 5345-5354). We will present an analysis of 7.8-μm images of Jupiter measured by COMICS (Cooled Mid-Infrared Camera and Spectrograph, Kataza et al., 2000, Proc. SPIE(4008), 1144-1152) on the Subaru telescope. These images were acquired on January 11th, 12th, 13th, 14th, February 4, 5th and May 17th, 18th, 19th and 20th in 2017, allowing the daily variability of Jupiter’s auroral-related stratospheric heating to be tracked. Preliminary results suggest lower stratospheric temperatures are directly forced by the solar wind dynamical pressure. The southern auroral hotspot exhibited a significant increase in brightness temperature over a 24-hour period. Over the same time period, a solar wind propagation model (Tao et al. 2005, JGR 110, A11208) predicts a strong increase in the solar wind dynamical pressure at Jupiter.

  8. The Factor Structure of Coordination Abilities Development in 5th-7th Grade Boys

    Directory of Open Access Journals (Sweden)

    В. В. Приходько

    2017-12-01

    Full Text Available The objective is to determine the structure of coordination abilities development in 5th-7th grade boys. Materials and methods. The participants in the study were boys of the 5th grade (n=21, 6th grade (n=20, and 7th grade (n=19. The paper used analysis and generalization of the scientific and methodological literature data, general scientific methods of theoretical level, namely: analogy, analysis, synthesis, abstracting, induction, as well as general scientific methods of empirical level: observation, testing, experiment. To evaluate of the motor preparedness, the results of motor tests, height and body weight were recorded. The materials of the study were processed in the statistical analysis program IBM SPSS 20. Factor analysis was carried out using a model of the principal components with the rotation method: Variamax with Kaiser normalization. Results. Analysis of the similarities shows that the most informative in the structure of the 5th grade boys’ motor preparedness are Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (,999, Test 2 “Standing Long Jump (cm” (,998, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,916; for the 6th grade boys such are Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (1.0, Test 2 “Standing Long Jump (cm” (,999, Test 5 “Sit-Up for 30 sec.” (,968, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,918; for the 7th grade boys such are Test 2 “Standing Long Jump (cm” (,994, Test 9 “Static Equilibrium Evaluation by E. Ya. Bondarevsky’s Method” (,987, Test 10 “Dynamic Equilibrium Evaluation by Bess Method” (,945. Conclusions. The most informative in the structure of 5th-7th grade boys’ coordination abilities is vestibular tolerance. For pedagogical control of 5th-7th grade boys’ motor preparedness the following can be recommended: Test 2 “Standing Long Jump (cm”, Test 9 “Static Equilibrium

  9. El bàcul de Sant Pere d'Àger: la pèrdua d'un unicum

    Directory of Open Access Journals (Sweden)

    Matas i Blanxart, Maria Teresa

    1999-12-01

    Full Text Available This study consists of an investigation about one missing crosier made of champlevé enamel. This object comes from the Sant Pere d'Ager church (Lleida. This piece is an unicum inside the enamels corpus of Catalonia for its personal iconography. We think that this piece of work by Limoges dates from the end of the 12th century or from the beginning of the 13th century.[fr] Nous présentons dans cet article un étude d'une crosse d'émail champlevé procédant de l'église de Sant Pere d'Ager (Lleida. Il est aujourd'hui perdu. Cet object pour la tematique iconographique est un unicum dans le corpus des émauxs champlevé catalans. Nous pouvons situer la chronologie de cette crosse en cuivre champlevé émaillé et doré, dans l'oeuvre de Limoges des derniers années du siècle XIIᵉ ou la première partie du XIIIᵉ siècle.

  10. Movement Coordination: Factor Structure of Development in 5th-7th Grade Girls

    Directory of Open Access Journals (Sweden)

    O. Ivashchenko

    2018-03-01

    Full Text Available The study objective is to determine the structure of coordination abilities development in 5th-7th grade girls. Materials and methods. The participants in the study were 5th grade girls (n = 20, 6th grade girls (n = 23, 7th grade girls (n = 19. The study used the following methods: analysis and collation of scientific and methodological literature, general scientific methods of theoretical level, such as analogy, analysis, synthesis, abstraction, induction, as well as general scientific methods of empirical level: observation, testing, experiment. To evaluate motor preparedness, the study recorded the results of motor tests, body height and weight. The IBM SPSS 20 statistical analysis software was used to process the study materials. A factor analysis was performed, for which the study used principal component analysis with the rotation method: Variamax with Kaiser Normalization. Results. The analysis of similarities shows that the most informative tests in the structure of motor preparedness of the 5th grade girls are the following: test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (.884, test 9 “Static equilibrium evaluation by E. Ya. Bondarevsky’s method” (.826, test 6 “Evaluation of the sense of movement speed in sprinting” (.824; of the 6th grade girls — test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (0.884, test 9 “Static equilibrium evaluation by E. Ya. Bondarevsky’s method” (.826, test 6 “Evaluation of the sense of movement speed in sprinting” (.824; of the 7th grade girls — test 8 “Evaluation of the ability to differentiate movement speed (reproduction accuracy of running speed at 90% intensity of maximum” (.902, test 11 “Evaluation of the ability for vestibular (statokinetic stability. Running with turns” (.900, test 1 “30 m running (s” (.869. Conclusions. In the structure of

  11. Valladolid, a Festival Town (17th-18th Centuries

    Directory of Open Access Journals (Sweden)

    Lourdes AMIGO VÁZQUEZ

    2017-11-01

    Full Text Available The festival was a great sociocultural event whose dimensions reached their maximum evolution in Early Modern Spain, especially in the 17th and 18th centuries and in its urban centres. This was the «festive society» par excellence, because of the frequency of the celebrations and the multiplicity of meanings, implications and consequences. Society and power, ultimately, were represented at the festival. In this context, the specific case of Valladolid demonstrates both its character as a germane model, applicable to any other town, and its uniqueness. Significantly, in the early 17th century it was once again the seat of the Court and yet even after being abandoned by Philip III in 1606, it continued to be one of the most important towns of Castile, the seat of the Royal Chancellery.

  12. ThNAC13, a NAC Transcription Factor from Tamarix hispida, Confers Salt and Osmotic Stress Tolerance to Transgenic Tamarix and Arabidopsis

    OpenAIRE

    Wang, Liuqiang; Li, Zhen; Lu, Mengzhu; Wang, Yucheng

    2017-01-01

    NAC (NAM, ATAF1/2, and CUC2) proteins play critical roles in many plant biological processes and environmental stress. However, NAC proteins from Tamarix hispida have not been functionally characterized. Here, we studied a NAC gene from T. hispida, ThNAC13, in response to salt and osmotic stresses. ThNAC13 is a nuclear protein with a C-terminal transactivation domain. ThNAC13 can bind to NAC recognized sites and calmodulin-binding NAC (CBNAC) binding element. Overexpression of ThNAC13 in Arab...

  13. Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review.

    Science.gov (United States)

    Asadi-Samani, Majid; Bagheri, Nader; Rafieian-Kopaei, Mahmoud; Shirzad, Hedayatollah

    2017-08-01

    Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants or plant derivatives that are effective on inflammatory diseases by inhibiting Th1 and Th17 responses. To achieve this purpose, the search terms herb, herbal medicine, herbal drug, medicinal plant, phytochemical, traditional Chinese medicine, Ayurvedic medicine, natural compound, inflammation, inflammatory diseases, Th1, Th17, T helper 1 or T helper 17 were used separately in Title/Keywords/Abstract in Web of Science and PubMed databases. In articles investigating the effect of the medicinal plants and their derivatives in inhibiting Th1 and Th17 cells, the effects of eight extracts of the medicinal plants, 21 plant-based compounds and some of their derivatives, and eight drugs derived from the medicinal plants' compounds in inhibiting Th1 and Th17 cells were reviewed. The results showed that medicinal plants and their derivates are able to suppress Th17 and Th1 T cell functions as well as cytokine secretion and differentiation. The results can be used to produce herbal drugs that suppress Th, especially Th17, responses. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  14. Understanding and Measuring Student Engagement in School: The Results of an International Study from 12 Countries

    Science.gov (United States)

    Lam, Shui-fong; Jimerson, Shane; Wong, Bernard P. H.; Kikas, Eve; Shin, Hyeonsook; Veiga, Feliciano H.; Hatzichristou, Chryse; Polychroni, Fotini; Cefai, Carmel; Negovan, Valeria; Stanculescu, Elena; Yang, Hongfei; Liu, Yi; Basnett, Julie; Duck, Robert; Farrell, Peter; Nelson, Brett; Zollneritsch, Josef

    2014-01-01

    The objective of the present study was to develop a scale that is appropriate for use internationally to measure affective, behavioral, and cognitive dimensions of student engagement. Psychometric properties of this scale were examined with data of 3,420 students (7th, 8th, and 9th grade) from 12 countries (Austria, Canada, China, Cyprus, Estonia,…

  15. STECH, 3(3), S/NO 12, SEPTEMBER, 2014

    African Journals Online (AJOL)

    DR Nneka

    2014-09-12

    Sep 12, 2014 ... Effectiveness of Using Floating Drum Bio-Digester to Treat ... municipal or industrial liquid waste products disposed of, usually via a ... Also as the world drifts towards the practice of green revolution, which ..... 4th = 489.32 lits.

  16. Developmental Thyroid Hormone (TH) Disruption: In Search of Sensitive Bioindicators of Altered TH-Dependent Signaling in Brain

    Science.gov (United States)

    Thyroid hormones (TH) are essential for brain development, yet clear indicators of disruption at low levels of TH insufficiency have yet to be identified. Brain TH is difficult to measure, but TH-responsive genes can serve as sensitive indicators of TH action in brain. A large nu...

  17. Developmental Thyroid Hormone (TH) Disruption: In Search of Sensitive Bioindicators of Altered TH-Dependent Signaling in Brain###

    Science.gov (United States)

    Thyroid hormones (TH) are essential for brain development, yet clear indicators of disruption at low levels of TH insufficiency have yet to be identified. Brain TH is difficult to measure, but TH-responsive genes can serve as sensitive indicators of TH action in brain. A large nu...

  18. Cloud regimes as phase transitions

    Science.gov (United States)

    Stechmann, Samuel; Hottovy, Scott

    2017-11-01

    Clouds are repeatedly identified as a leading source of uncertainty in future climate predictions. Of particular importance are stratocumulus clouds, which can appear as either (i) closed cells that reflect solar radiation back to space or (ii) open cells that allow solar radiation to reach the Earth's surface. Here we show that these clouds regimes - open versus closed cells - fit the paradigm of a phase transition. In addition, this paradigm characterizes pockets of open cells (POCs) as the interface between the open- and closed-cell regimes, and it identifies shallow cumulus clouds as a regime of higher variability. This behavior can be understood using an idealized model for the dynamics of atmospheric water as a stochastic diffusion process. Similar viewpoints of deep convection and self-organized criticality will also be discussed. With these new conceptual viewpoints, ideas from statistical mechanics could potentially be used for understanding uncertainties related to clouds in the climate system and climate predictions. The research of S.N.S. is partially supported by a Sloan Research Fellowship, ONR Young Investigator Award N00014-12-1-0744, and ONR MURI Grant N00014-12-1-0912.

  19. Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

    DEFF Research Database (Denmark)

    Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza M. H.

    2017-01-01

    Background: Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously we have shown that only Th1...... mice where trafficking of Th1 cells into the CNS was affected. We compared microglia and astrocyte response in the brain and spinal cord of these mice. We further treated astrocytes with supernatants from highly pure Th1 and Th17 cultures and assessed the mRNA expression of neurotrophic factors......, cytokines and chemokines using real-time PCR. Data obtained was analysed using Kruskal- Wallis test. Results: We observed in α4-deficient mice weak microglial activation but comparable astrogliosis to that of wild-type mice in the regions of the brain populated with Th17 infiltrates suggesting that Th17...

  20. IL-17/Th17 Pathway Is Activated in Acne Lesions

    Science.gov (United States)

    Kelhälä, Hanna-Leena; Palatsi, Riitta; Fyhrquist, Nanna; Lehtimäki, Sari; Väyrynen, Juha P.; Kallioinen, Matti; Kubin, Minna E.; Greco, Dario; Tasanen, Kaisa; Alenius, Harri; Bertino, Beatrice; Carlavan, Isabelle; Mehul, Bruno; Déret, Sophie; Reiniche, Pascale; Martel, Philippe; Marty, Carine; Blume-Peytavi, Ulrike; Voegel, Johannes J.; Lauerma, Antti

    2014-01-01

    The mechanisms of inflammation in acne are currently subject of intense investigation. This study focused on the activation of adaptive and innate immunity in clinically early visible inflamed acne lesions and was performed in two independent patient populations. Biopsies were collected from lesional and non-lesional skin of acne patients. Using Affymetrix Genechips, we observed significant elevation of the signature cytokines of the Th17 lineage in acne lesions compared to non-lesional skin. The increased expression of IL-17 was confirmed at the RNA and also protein level with real-time PCR (RT-PCR) and Luminex technology. Cytokines involved in Th17 lineage differentiation (IL-1β, IL-6, TGF-β, IL23p19) were remarkably induced at the RNA level. In addition, proinflammatory cytokines and chemokines (TNF-α, IL-8, CSF2 and CCL20), Th1 markers (IL12p40, CXCR3, T-bet, IFN-γ), T regulatory cell markers (Foxp3, IL-10, TGF-β) and IL-17 related antimicrobial peptides (S100A7, S100A9, lipocalin, hBD2, hBD3, hCAP18) were induced. Importantly, immunohistochemistry revealed significantly increased numbers of IL-17A positive T cells and CD83 dendritic cells in the acne lesions. In summary our results demonstrate the presence of IL-17A positive T cells and the activation of Th17-related cytokines in acne lesions, indicating that the Th17 pathway is activated and may play a pivotal role in the disease process, possibly offering new targets of therapy. PMID:25153527