Sample records for primary core analysis

  1. Behavior of an heterogeneous annular FBR core during an unprotected loss of flow accident: Analysis of the primary phase with SAS-SFR

    Massara, S.; Schmitt, D.; Bretault, A.; Lemasson, D.; Darmet, G.; Verwaerde, D. [EDF R and D, 1, Avenue du General de Gaulle, 92141 Clamart (France); Struwe, D.; Pfrang, W.; Ponomarev, A. [Karlsruher Institut fuer Technologie KIT, Institut fuer Neutronenphysik und Reaktortechnik INR, Hermann-von-Helmholtz-Platz 1, Gebaude 521, 76344 Eggenstein-Leopoldshafen (Germany)


    In the framework of a substantial improvement on FBR core safety connected to the development of a new Gen IV reactor type, heterogeneous core with innovative features are being carefully analyzed in France since 2009. At EDF R and D, the main goal is to understand whether a strong reduction of the Na-void worth - possibly attempting a negative value - allows a significant improvement of the core behavior during an unprotected loss of flow accident. Also, the physical behavior of such a core is of interest, before and beyond the (possible) onset of Na boiling. Hence, a cutting-edge heterogeneous design, featuring an annular shape, a Na-plena with a B{sub 4}C plate and a stepwise modulation of fissile core heights, was developed at EDF by means of the SDDS methodology, with a total Na-void worth of -1 $. The behavior of such a core during the primary phase of a severe accident, initiated by an unprotected loss of flow, is analyzed by means of the SAS-SFR code. This study is carried-out at KIT and EDF, in the framework of a scientific collaboration on innovative FBR severe accident analyses. The results show that the reduction of the Na-void worth is very effective, but is not sufficient alone to avoid Na-boiling and, hence, to prevent the core from entering into the primary phase of a severe accident. Nevertheless, the grace time up to boiling onset is greatly enhanced in comparison to a more traditional homogeneous core design, and only an extremely low fraction of the fuel (<0.1%) enters into melting at the end of this phase. A sensitivity analysis shows that, due to the inherent neutronic characteristics of such a core, the gagging scheme plays a major role on the core behavior: indeed, an improved 4-zones gagging scheme, associated with an enhanced control rod drive line expansion feed-back effect, finally prevents the core from entering into sodium boiling. This major conclusion highlights both the progress already accomplished and the need for more detailed

  2. Modified Anchor Shaped Post Core Design for Primary Anterior Teeth

    R. Rajesh; Kusai Baroudi; K. Bala Kasi Reddy; Praveen, B. H.; V. Sumanth Kumar; Amit, S


    Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  3. Modified Anchor Shaped Post Core Design for Primary Anterior Teeth

    R. Rajesh


    Full Text Available Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  4. Modified anchor shaped post core design for primary anterior teeth.

    Rajesh, R; Baroudi, Kusai; Reddy, K Bala Kasi; Praveen, B H; Kumar, V Sumanth; Amit, S


    Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  5. Core-seis: a code for LMFBR core seismic analysis

    Chellapandi, P.; Ravi, R.; Chetal, S.C.; Bhoje, S.B. [Indira Gandhi Centre for Atomic Research, Kalpakkam (India). Reactor Group


    This paper deals with a computer code CORE-SEIS specially developed for seismic analysis of LMFBR core configurations. For demonstrating the prediction capability of the code, results are presented for one of the MONJU reactor core mock ups which deals with a cluster of 37 subassemblies kept in water. (author). 3 refs., 7 figs., 2 tabs.

  6. Primary Sources. Update: Teachers' Views on Common Core State Standards

    Scholastic Inc. and the Bill & Melinda Gates Foundation, 2014


    Scholastic and the Bill & Melinda Gates Foundation fielded the third edition of the "Primary Sources" survey of America's teachers in July 2013 (see ED562664). Twenty thousand pre-K through grade 12 public school teachers responded, sharing their perspectives on issues important to their profession, including the Common Core State…

  7. Monolingual and bilingual children with and without primary language impairment: core vocabulary comparison.

    Robillard, Manon; Mayer-Crittenden, Chantal; Minor-Corriveau, Michèle; Bélanger, Roxanne


    Core vocabulary is an important component of augmentative and alternative communication (AAC) systems for school-aged children who have complex communication needs. One method of identifying core vocabulary for these individuals is to study the vocabulary of speaking children. To date, the use of core vocabulary by speaking bilingual children has not been well documented. The present study compared the core vocabulary used by children who are monolingual (French), and bilingual (French-English; English-French). We also gathered and compared language samples from French-speaking children identified as having primary language impairment (PLI), with the goal of better understanding the language differences demonstrated by children with this disability. Language samples were collected from a total of 57 children within a school setting, in a region where French is a minority language. Contrary to the hypothesis, the analysis of language transcripts revealed that there were no important differences between the core words from the groups studied.

  8. Analysis of circuits including magnetic cores (MTRAC)

    Hanzen, G. R.; Nitzan, D.; Herndon, J. R.


    Development of automated circuit analysis computer program to provide transient analysis of circuits with magnetic cores is discussed. Allowance is made for complications caused by nonlinearity of switching core model and magnetic coupling among loop currents. Computer program is conducted on Univac 1108 computer using FORTRAN IV.

  9. Value of computed tomography-guided core needle biopsy in diagnosis of primary pulmonary lymphomas.

    Wang, Zhiwei; Li, Xiaoguang; Chen, Jin; Jin, Zhengyu; Shi, Haifeng; Zhang, Xiaobo; Pan, Jie; Liu, Wei; Yang, Ning; Chen, Jie


    To evaluate the value of computed tomography (CT)-guided core needle biopsy in diagnosis of primary pulmonary lymphoma and its subtypes. A retrospective analysis of the records of all patients with primary pulmonary lymphoma between January 2005 and August 2011 was performed. There were 25 patients referred to the radiology department for CT-guided core needle biopsy. The success rate and complications were assessed. A definitive diagnosis and accurate histologic subtype were obtained in 21 patients with a success rate of 84.0%. Diagnosis was made in the other four patients with bronchoscopy and surgery. Non-Hodgkin lymphoma (NHL) was the diagnosis in all patients. Most subtypes were mucosa-associated lymphoid tissue (MALT) lymphomas (n = 19). The remaining subtypes included three diffuse large B-cell NHLs, two peripheral T-cell lymphomas not otherwise specified, and one anaplastic large cell NHL. The success rate of core needle biopsy was 95% (18 of 19) for MALT lymphomas, 67% (2 of 3) for diffuse large B cell NHLs, and 33% (1 of 3) for other NHLs. The success rate for MALT lymphomas was significantly higher than that of non-MALT lymphomas according to Fisher exact t test (P = .031). No serious complications occurred in any patients. CT-guided core needle biopsy is a reliable procedure to assist in diagnosis and classification of primary pulmonary lymphomas, especially MALT lymphomas. Copyright © 2013 SIR. Published by Elsevier Inc. All rights reserved.

  10. Thermal hydraulic analysis of the JMTR improved LEU-core

    Tabata, Toshio; Nagao, Yoshiharu; Komukai, Bunsaku; Naka, Michihiro; Fujiki, Kazuo [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Takeda, Takashi [Radioactive Waste Management and Nuclear Facility Decommissioning Technology Center, Tokai, Ibaraki (Japan)


    After the investigation of the new core arrangement for the JMTR reactor in order to enhance the fuel burn-up and consequently extend the operation period, the ''improved LEU core'' that utilized 2 additional fuel elements instead of formerly installed reflector elements, was adopted. This report describes the results of the thermal-hydraulic analysis of the improved LEU core as a part of safety analysis for the licensing. The analysis covers steady state, abnormal operational transients and accidents, which were described in the annexes of the licensing documents as design bases events. Calculation conditions for the computer codes were conservatively determined based on the neutronic analysis results and others. The results of the analysis, that revealed the safety criteria were satisfied on the fuel temperature, DNBR and primary coolant temperature, were used in the licensing. The operation license of the JMTR with the improved LEU core was granted in March 2001, and the reactor operation with new core started in November 2001 as 142nd operation cycle. (author)

  11. Degraded core analysis for the PWR

    Gittus, J.H.


    The paper presents an analysis of the probability and consequences of degraded core accidents for the PWR. The article is based on a paper which was presented by the author to the Sizewell-B public inquiry. Degraded core accidents are examined with respect to:- the initiating events, safety plant failure, and processes with a bearing on containment failure. Accident types and frequencies are discussed, as well as the dispersion of radionuclides. Accident risks, i.e. individual and societal risks in degraded core accidents are assessed from:- the amount of radionuclides released, the weather, the population distribution, and the accident frequencies. Uncertainties in the assessment of degraded core accidents are also summarized. (U.K.).

  12. Overview on Hydrate Coring, Handling and Analysis

    Jon Burger; Deepak Gupta; Patrick Jacobs; John Shillinglaw


    Gas hydrates are crystalline, ice-like compounds of gas and water molecules that are formed under certain thermodynamic conditions. Hydrate deposits occur naturally within ocean sediments just below the sea floor at temperatures and pressures existing below about 500 meters water depth. Gas hydrate is also stable in conjunction with the permafrost in the Arctic. Most marine gas hydrate is formed of microbially generated gas. It binds huge amounts of methane into the sediments. Worldwide, gas hydrate is estimated to hold about 1016 kg of organic carbon in the form of methane (Kvenvolden et al., 1993). Gas hydrate is one of the fossil fuel resources that is yet untapped, but may play a major role in meeting the energy challenge of this century. In June 2002, Westport Technology Center was requested by the Department of Energy (DOE) to prepare a ''Best Practices Manual on Gas Hydrate Coring, Handling and Analysis'' under Award No. DE-FC26-02NT41327. The scope of the task was specifically targeted for coring sediments with hydrates in Alaska, the Gulf of Mexico (GOM) and from the present Ocean Drilling Program (ODP) drillship. The specific subjects under this scope were defined in 3 stages as follows: Stage 1: Collect information on coring sediments with hydrates, core handling, core preservation, sample transportation, analysis of the core, and long term preservation. Stage 2: Provide copies of the first draft to a list of experts and stakeholders designated by DOE. Stage 3: Produce a second draft of the manual with benefit of input from external review for delivery. The manual provides an overview of existing information available in the published literature and reports on coring, analysis, preservation and transport of gas hydrates for laboratory analysis as of June 2003. The manual was delivered as draft version 3 to the DOE Project Manager for distribution in July 2003. This Final Report is provided for records purposes.

  13. CFD Analysis of Core Bypass Phenomena

    Richard W. Johnson; Hiroyuki Sato; Richard R. Schultz


    The U.S. Department of Energy is exploring the potential for the VHTR which will be either of a prismatic or a pebble-bed type. One important design consideration for the reactor core of a prismatic VHTR is coolant bypass flow which occurs in the interstitial regions between fuel blocks. Such gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The existence of the gaps induces a flow bias in the fuel blocks and results in unexpected increase of maximum fuel temperature. Traditionally, simplified methods such as flow network calculations employing experimental correlations are used to estimate flow and temperature distributions in the core design. However, the distribution of temperature in the fuel pins and graphite blocks as well as coolant outlet temperatures are strongly coupled with the local heat generation rate within fuel blocks which is not uniformly distributed in the core. Hence, it is crucial to establish mechanistic based methods which can be applied to the reactor core thermal hydraulic design and safety analysis. Computational Fluid Dynamics (CFD) codes, which have a capability of local physics based simulation, are widely used in various industrial fields. This study investigates core bypass flow phenomena with the assistance of commercial CFD codes and establishes a baseline for evaluation methods. A one-twelfth sector of the hexagonal block surface is modeled and extruded down to whole core length of 10.704m. The computational domain is divided vertically with an upper reflector, a fuel section and a lower reflector. Each side of the sector grid can be set as a symmetry boundary

  14. CFD Analysis of Core Bypass Phenomena

    Richard W. Johnson; Hiroyuki Sato; Richard R. Schultz


    The U.S. Department of Energy is exploring the potential for the VHTR which will be either of a prismatic or a pebble-bed type. One important design consideration for the reactor core of a prismatic VHTR is coolant bypass flow which occurs in the interstitial regions between fuel blocks. Such gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The existence of the gaps induces a flow bias in the fuel blocks and results in unexpected increase of maximum fuel temperature. Traditionally, simplified methods such as flow network calculations employing experimental correlations are used to estimate flow and temperature distributions in the core design. However, the distribution of temperature in the fuel pins and graphite blocks as well as coolant outlet temperatures are strongly coupled with the local heat generation rate within fuel blocks which is not uniformly distributed in the core. Hence, it is crucial to establish mechanistic based methods which can be applied to the reactor core thermal hydraulic design and safety analysis. Computational Fluid Dynamics (CFD) codes, which have a capability of local physics based simulation, are widely used in various industrial fields. This study investigates core bypass flow phenomena with the assistance of commercial CFD codes and establishes a baseline for evaluation methods. A one-twelfth sector of the hexagonal block surface is modeled and extruded down to whole core length of 10.704m. The computational domain is divided vertically with an upper reflector, a fuel section and a lower reflector. Each side of the one-twelfth grid can be set as a symmetry boundary

  15. Clinical data integration model. Core interoperability ontology for research using primary care data.

    Ethier, J-F; Curcin, V; Barton, A; McGilchrist, M M; Bastiaens, H; Andreasson, A; Rossiter, J; Zhao, L; Arvanitis, T N; Taweel, A; Delaney, B C; Burgun, A


    This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". Primary care data is the single richest source of routine health care data. However its use, both in research and clinical work, often requires data from multiple clinical sites, clinical trials databases and registries. Data integration and interoperability are therefore of utmost importance. TRANSFoRm's general approach relies on a unified interoperability framework, described in a previous paper. We developed a core ontology for an interoperability framework based on data mediation. This article presents how such an ontology, the Clinical Data Integration Model (CDIM), can be designed to support, in conjunction with appropriate terminologies, biomedical data federation within TRANSFoRm, an EU FP7 project that aims to develop the digital infrastructure for a learning healthcare system in European Primary Care. TRANSFoRm utilizes a unified structural / terminological interoperability framework, based on the local-as-view mediation paradigm. Such an approach mandates the global information model to describe the domain of interest independently of the data sources to be explored. Following a requirement analysis process, no ontology focusing on primary care research was identified and, thus we designed a realist ontology based on Basic Formal Ontology to support our framework in collaboration with various terminologies used in primary care. The resulting ontology has 549 classes and 82 object properties and is used to support data integration for TRANSFoRm's use cases. Concepts identified by researchers were successfully expressed in queries using CDIM and pertinent terminologies. As an example, we illustrate how, in TRANSFoRm, the Query Formulation Workbench can capture eligibility criteria in a computable representation, which is based on CDIM. A unified mediation approach to semantic interoperability provides a

  16. Core Backbone Convergence Mechanisms and Microloops Analysis

    Abdelali Ala


    Full Text Available In this article we study approaches that can be used to minimise the convergence time, we also make a focus on microloops phenomenon, analysis and means to mitigate them. The convergence time reflects the time required by a network to react to a failure of a link or a router failure itself. When all nodes (routers have updated their respective routing and forwarding databases, we can say the network has converged. This study will help in building real-time and resilient network infrastructure, the goal is to make any evenement in the core network, as transparent as possible to any sensitive and real-time flows. This study is also, a deepening of earlier works presented in [10] and [11].

  17. Multi-Core Processor Memory Contention Benchmark Analysis Case Study

    Simon, Tyler; McGalliard, James


    Multi-core processors dominate current mainframe, server, and high performance computing (HPC) systems. This paper provides synthetic kernel and natural benchmark results from an HPC system at the NASA Goddard Space Flight Center that illustrate the performance impacts of multi-core (dual- and quad-core) vs. single core processor systems. Analysis of processor design, application source code, and synthetic and natural test results all indicate that multi-core processors can suffer from significant memory subsystem contention compared to similar single-core processors.

  18. Developing a Core Competency Model and Educational Framework for Primary Maternity Services: a national consensus approach.

    Homer, Caroline S E; Griffiths, Marnie; Brodie, Pat M; Kildea, Sue; Curtin, Austin M; Ellwood, David A


    An appropriately educated and competent workforce is crucial to an effective health care system. The National Health Workforce Taskforce (now Health Workforce Australia) and the Maternity Services Inter-Jurisdictional Committee funded a project to develop Core Competencies and Educational Framework for Primary Maternity Services in Australia. These competencies recognise the interdisciplinary nature of maternity care in Australia where care is provided by general practitioners, obstetricians and midwives as well as other professionals. Key stakeholders from professional organisations and providers of services related to maternity care and consumers of services. A national consensus approach was undertaken using consultation processes with a Steering Committee, a wider Reference Group and public consultation. A national Core Competencies and Educational Framework for Primary Maternity Services in Australia was developed through an iterative process with a range of key stakeholders. There are a number of strategies that may assist in the integration of these into primary maternity service provider professional groups' education and practice. The Core Competencies and Educational Framework are based on an interprofessional approach to learning and primary maternity service practice. They have sought to value professional expertise and stimulate awareness and respect for the roles of all primary maternity service providers. The competencies and framework described in this paper are now a critical component of Australian maternity services as they are included in actions in the newly released National Maternity Services Plan and thus have relevance for all providers of Australian maternity services. Copyright © 2011 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  19. Neural Response Properties of Primary, Rostral, and Rostrotemporal Core Fields in the Auditory Cortex of Marmoset Monkeys

    Bendor, Daniel; WANG, Xiaoqin


    The core region of primate auditory cortex contains a primary and two primary-like fields (AI, primary auditory cortex; R, rostral field; RT, rostrotemporal field). Although it is reasonable to assume that multiple core fields provide an advantage for auditory processing over a single primary field, the differential roles these fields play and whether they form a functional pathway collectively such as for the processing of spectral or temporal information are unknown. In this report we compa...

  20. Preliminaries on core image analysis using fault drilling samples; Core image kaiseki kotohajime (danso kussaku core kaisekirei)

    Miyazaki, T.; Ito, H. [Geological Survey of Japan, Tsukuba (Japan)


    This paper introduces examples of image data analysis on fault drilling samples. The paper describes the following matters: core samples used in the analysis are those obtained from wells drilled piercing the Nojima fault which has moved in the Hygoken-Nanbu Earthquake; the CORESCAN system made by DMT Corporation, Germany, used in acquiring the image data consists of a CCD camera, a light source and core rotation mechanism, and a personal computer, its resolution being about 5 pixels/mm in both axial and circumferential directions, and 24-bit full color; with respect to the opening fractures in core samples collected by using a constant azimuth coring, it was possible to derive values of the opening width, inclination angle, and travel from the image data by using a commercially available software for the personal computer; and comparison of this core image with the BHTV record and the hydrophone VSP record (travel and inclination obtained from the BHTV record agree well with those obtained from the core image). 4 refs., 4 figs.

  1. Hybrid Analysis of Engine Core Noise

    O'Brien, Jeffrey; Kim, Jeonglae; Ihme, Matthias


    Core noise, or the noise generated within an aircraft engine, is becoming an increasing concern for the aviation industry as other noise sources are progressively reduced. The prediction of core noise generation and propagation is especially challenging for computationalists since it involves extensive multiphysics including chemical reaction and moving blades in addition to the aerothermochemical effects of heated jets. In this work, a representative engine flow path is constructed using experimentally verified geometries to simulate the physics of core noise. A combustor, single-stage turbine, nozzle and jet are modeled in separate calculations using appropriate high fidelity techniques including LES, actuator disk theory and Ffowcs-Williams Hawkings surfaces. A one way coupling procedure is developed for passing fluctuations downstream through the flowpath. This method effectively isolates the core noise from other acoustic sources, enables straightforward study of the interaction between core noise and jet exhaust, and allows for simple distinction between direct and indirect noise. The impact of core noise on the farfield jet acoustics is studied extensively and the relative efficiency of different disturbance types and shapes is examined in detail.

  2. Advanced Materials and Solids Analysis Research Core (AMSARC)

    The Advanced Materials and Solids Analysis Research Core (AMSARC), centered at the U.S. Environmental Protection Agency's (EPA) Andrew W. Breidenbach Environmental Research Center in Cincinnati, Ohio, is the foundation for the Agency's solids and surfaces analysis capabilities. ...

  3. Advanced Materials and Solids Analysis Research Core (AMSARC)

    The Advanced Materials and Solids Analysis Research Core (AMSARC), centered at the U.S. Environmental Protection Agency's (EPA) Andrew W. Breidenbach Environmental Research Center in Cincinnati, Ohio, is the foundation for the Agency's solids and surfaces analysis capabilities. ...

  4. Molecular double core-hole electron spectroscopy for chemical analysis

    Tashiro, Motomichi; Fukuzawa, Hironobu; Ueda, Kiyoshi; Buth, Christian; Kryzhevoi, Nikolai V; Cederbaum, Lorenz S


    We explore the potential of double core hole electron spectroscopy for chemical analysis in terms of x-ray two-photon photoelectron spectroscopy (XTPPS). The creation of deep single and double core vacancies induces significant reorganization of valence electrons. The corresponding relaxation energies and the interatomic relaxation energies are evaluated by CASSCF calculations. We propose a method how to experimentally extract these quantities by the measurement of single and double core-hole ionization potentials (IPs and DIPs). The influence of the chemical environment on these DIPs is also discussed for states with two holes at the same atomic site and states with two holes at two different atomic sites. Electron density difference between the ground and double core-hole states clearly shows the relaxations accompanying the double core-hole ionization. The effect is also compared with the sensitivity of single core hole ionization potentials (IPs) arising in single core hole electron spectroscopy. We have ...

  5. Core competencies in sexual and reproductive health for the interprofessional primary care team.

    Cappiello, Joyce; Levi, Amy; Nothnagle, Melissa


    A primary care workforce that is well prepared to provide high-quality sexual and reproductive health (SRH) care has the potential to enhance access to care and reduce health disparities. This project aimed to identify core competencies to guide SRH training across the primary care professions. A six-member interprofessional expert working group drafted SRH competencies for primary care team members. Primary care providers including family physicians, nurses, nurse practitioners and certified nurse midwives, physician assistants and pharmacists were invited to participate in a three-round electronic Delphi survey. In each round, participants voted by email to retain, eliminate or revise each competency, with their suggested edits to the competencies incorporated by the researchers after each round. Fifty providers from six professions participated. In Round 1, 17 of 33 draft competencies reached the 75% predetermined agreement level to be accepted as written. Five were combined, reducing the total number to 28. Based on Round 2 feedback, 21 competencies were reworded, and 2 were combined. In Round 3, all 26 competencies reached at least 83.7% agreement, with 9 achieving 100% agreement. The 33 core competencies encompass professional ethics and reproductive justice, collaboration, SRH services and conditions affecting SRH. These core competencies will be disseminated and adapted to each profession's scope of practice to inform required curricula. SRH competencies for primary care can inform the required curricula across professions, filling the gap between an established standard of care necessary to meet patient needs and the outcomes of that care. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Conceptual study of advanced PWR core design. Development of advanced PWR core neutronics analysis system

    Kim, Chang Hyo; Kim, Seung Cho; Kim, Taek Kyum; Cho, Jin Young; Lee, Hyun Cheol; Lee, Jung Hun; Jung, Gu Young [Seoul National University, Seoul (Korea, Republic of)


    The neutronics design system of the advanced PWR consists of (i) hexagonal cell and fuel assembly code for generation of homogenized few-group cross sections and (ii) global core neutronics analysis code for computations of steady-state pin-wise or assembly-wise core power distribution, core reactivity with fuel burnup, control rod worth and reactivity coefficients, transient core power, etc.. The major research target of the first year is to establish the numerical method and solution of multi-group diffusion equations for neutronics code development. Specifically, the following studies are planned; (i) Formulation of various numerical methods such as finite element method(FEM), analytical nodal method(ANM), analytic function expansion nodal(AFEN) method, polynomial expansion nodal(PEN) method that can be applicable for the hexagonal core geometry. (ii) Comparative evaluation of the numerical effectiveness of these methods based on numerical solutions to various hexagonal core neutronics benchmark problems. Results are follows: (i) Formulation of numerical solutions to multi-group diffusion equations based on numerical methods. (ii) Numerical computations by above methods for the hexagonal neutronics benchmark problems such as -VVER-1000 Problem Without Reflector -VVER-440 Problem I With Reflector -Modified IAEA PWR Problem Without Reflector -Modified IAEA PWR Problem With Reflector -ANL Large Heavy Water Reactor Problem -Small HTGR Problem -VVER-440 Problem II With Reactor (iii) Comparative evaluation on the numerical effectiveness of various numerical methods. (iv) Development of HEXFEM code, a multi-dimensional hexagonal core neutronics analysis code based on FEM. In the target year of this research, the spatial neutronics analysis code for hexagonal core geometry(called NEMSNAP-H temporarily) will be completed. Combination of NEMSNAP-H with hexagonal cell and assembly code will then equip us with hexagonal core neutronics design system. (Abstract Truncated)

  7. Thermal analysis of HTS air-core transformer used in voltage compensation type active SFCL

    Song, M.; Tang, Y.; Li, J.; Zhou, Y.; Chen, L.; Ren, L.


    The three-phase voltage compensation type active superconducting fault current limiter (SFCL) is composed of three HTS air-core transformers and a three-phase four-wire Pulse Width Modulation (PWM) converter. The primary winding of the each phase HTS air-core transformer is in series with the main system, and the second winding is connected with the PWM converter. The single-phase conduction-cooled HTS air-core transformer is consisting of four double-pancakes wound by the Bi2223/Ag tape. In this paper, according to the electromagnetic analysis on the single-phase HTS air-core transformer, its AC loss corresponding to different operation modes is calculated. Furthermore, the thermal behaviors are studied by the time-stepping numerical simulations. On the basis of the simulation results, the related problems with the HTS air-core transformer's thermal stability are discussed.

  8. Core Competence Analysis--Toyota Production System



      Core competencies are the wel spring of new business development. It is the sharpest sword to penetrate the mature market, hold and enlarge the existing share. Toyota makes wel use of its TPS and form its own style which other car manufacturers hard to imitate.In contrast,the Chinese company---FAW only imitating the superficial aspects from Toyota and ignoring its own problems in manufacture line.

  9. Analysis of heterogeneous boron dilution transients during outages with APROS 3D nodal core model

    Kuopanportti, Jaakko [Fortum Power and Heat Ltd, Nuclear Production, Fortum (Finland)


    A diluted water plug can form inside the primary coolant circuit if the coolant flow has stopped at least temporarily. The source of the clean water can be external or the fresh water can build up internally during boiling/condensing heat transfer mode, which can occur if the primary coolant inventory has decreased enough during an accident. If the flow restarts in the stagnant primary loop, the diluted water plug can enter the reactor core. During outages after the fresh fuel has been loaded and the temperature of the coolant is low, the dilution potential is the highest because the critical boron concentration is at the maximum. This paper examines the behaviour of the core as clean or diluted water plugs of different sizes enter the core during outages. The analysis were performed with the APROS 3D nodal core model of Loviisa VVER-440, which contains an own flow channel and 10 axial nodes for each fuel assembly. The widerange cross section data was calculated with CASMO-4E. According to the results, the core can withstand even large pure water plugs without fuel failures on natural circulation. The analyses emphasize the importance of the simulation of the backflows inside the core when the reactor is on natural circulation.


    Clark, J. S.


    One of the most important factors in the development of nuclear rocket engine designs is to be able to accurately predict temperatures and pressures throughout a fission nuclear reactor core with axial hydrogen flow through circular coolant passages. CAC is an analytical prediction program to study the heat transfer and fluid flow characteristics of a circular coolant passage. CAC predicts as a function of time axial and radial fluid conditions, passage wall temperatures, flow rates in each coolant passage, and approximate maximum material temperatures. CAC incorporates the hydrogen properties model STATE to provide fluid-state relations, thermodynamic properties, and transport properties of molecular hydrogen in any fixed ortho-para combination. The program requires the general core geometry, the core material properties as a function of temperature, the core power profile, and the core inlet conditions as function of time. Although CAC was originally developed in FORTRAN IV for use on an IBM 7094, this version is written in ANSI standard FORTRAN 77 and is designed to be machine independent. It has been successfully compiled on IBM PC series and compatible computers running MS-DOS with Lahey F77L, a Sun4 series computer running SunOS 4.1.1, and a VAX series computer running VMS 5.4-3. CAC requires 300K of RAM under MS-DOS, 422K of RAM under SunOS, and 220K of RAM under VMS. No sample executable is provided on the distribution medium. Sample input and output data are included. The standard distribution medium for this program is a 5.25 inch 360K MS-DOS format diskette. CAC was developed in 1966, and this machine independent version was released in 1992. IBM-PC and IBM are registered trademarks of International Business Machines. Lahey F77L is a registered trademark of Lahey Computer Systems, Inc. SunOS is a trademark of Sun Microsystems, Inc. VMS is a trademark of Digital Equipment Corporation. MS-DOS is a registered trademark of Microsoft Corporation.


    Susan S. Sorini; John F. Schabron; Joseph F. Rovani Jr


    Soil sampling and storage practices for volatile organic analysis must be designed to minimize loss of volatile organic compounds (VOCs) from samples. The En Core{reg_sign} sampler is designed to collect and store soil samples in a manner that minimizes loss of contaminants due to volatilization and/or biodegradation. An ASTM International (ASTM) standard practice, D 6418, Standard Practice for Using the Disposable En Core Sampler for Sampling and Storing Soil for Volatile Organic Analysis, describes use of the En Core sampler to collect and store a soil sample of approximately 5 grams or 25 grams for volatile organic analysis and specifies sample storage in the En Core sampler at 4 {+-} 2 C for up to 48 hours; -7 to -21 C for up to 14 days; or 4 {+-} 2 C for up to 48 hours followed by storage at -7 to -21 C for up to five days. This report discusses activities performed during the past year to promote and continue acceptance of the En Core samplers based on their performance to store soil samples for VOC analysis. The En Core sampler is designed to collect soil samples for VOC analysis at the soil surface. To date, a sampling tool for collecting and storing subsurface soil samples for VOC analysis is not available. Development of a subsurface VOC sampling/storage device was initiated in 1999. This device, which is called the Accu Core{trademark} sampler, is designed so that a soil sample can be collected below the surface using a dual-tube penetrometer and transported to the laboratory for analysis in the same container. Laboratory testing of the current Accu Core design shows that the device holds low-level concentrations of VOCs in soil samples during 48-hour storage at 4 {+-} 2 C and that the device is ready for field evaluation to generate additional performance data. This report discusses a field validation exercise that was attempted in Pennsylvania in 2004 and activities being performed to plan and conduct a field validation study in 2006. A draft ASTM

  12. Continuous flow analysis of labile iron in ice-cores.

    Hiscock, William T; Fischer, Hubertus; Bigler, Matthias; Gfeller, Gideon; Leuenberger, Daiana; Mini, Olivia


    The important active and passive role of mineral dust aerosol in the climate and the global carbon cycle over the last glacial/interglacial cycles has been recognized. However, little data on the most important aeolian dust-derived biological micronutrient, iron (Fe), has so far been available from ice-cores from Greenland or Antarctica. Furthermore, Fe deposition reconstructions derived from the palaeoproxies particulate dust and calcium differ significantly from the Fe flux data available. The ability to measure high temporal resolution Fe data in polar ice-cores is crucial for the study of the timing and magnitude of relationships between geochemical events and biological responses in the open ocean. This work adapts an existing flow injection analysis (FIA) methodology for low-level trace Fe determinations with an existing glaciochemical analysis system, continuous flow analysis (CFA) of ice-cores. Fe-induced oxidation of N,N'-dimethyl-p-pheylenediamine (DPD) is used to quantify the biologically more important and easily leachable Fe fraction released in a controlled digestion step at pH ~1.0. The developed method was successfully applied to the determination of labile Fe in ice-core samples collected from the Antarctic Byrd ice-core and the Greenland Ice-Core Project (GRIP) ice-core.

  13. Application Analysis of Strengthened Story in Frame-Core Structures

    SU Yuan; CHEN Chuan-yao; LI Li


    Lateral deflection formulas are presented for analysis of the strengthened story applied to frame-core structures. For the frame-core structures with top outriggers and with middle outriggers, the relationship between stiffness characteristic parameters of frame and outriggers and the top drift of structures under different loads is analyzed. It is indicated that when stiffness characteristic parameter of frame is large, outrigger efficiency for top drift reduction is low, and the mutation of internal forces occurs; when the stiffness characteristic parameter of frame is less than 3, installing the strengthened story is advantageous to frame-core structures.

  14. TMI-2 accident: core heat-up analysis

    Ardron, K.H.; Cain, D.G.


    This report summarizes NSAC study of reactor core thermal conditions during the accident at Three Mile Island, Unit 2. The study focuses primarily on the time period from core uncovery (approximately 113 minutes after turbine trip) through the initiation of sustained high pressure injection (after 202 minutes). The transient analysis is based upon established sequences of events; plant data; post-accident measurements; interpretation or indirect use of instrument responses to accident conditions.

  15. CORE

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin


    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  16. CORE

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin


    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  17. Primary Metabolic Pathways and Metabolic Flux Analysis


    his chapter introduces the metabolic flux analysis (MFA) or stoichiometry-based MFA, and describes the quantitative basis for MFA. It discusses the catabolic pathways in which free energy is produced to drive the cell-building anabolic pathways. An overview of these primary pathways provides...

  18. Petrographic Analysis of Cores from Plant 42


    27  DISCLAIMER: The contents of this report are not to be used for advertising , publication...Department of the Army position unless so designated by other authorized documents. DESTROY THIS REPORT WHEN NO LONGER NEEDED. DO NOT RETURN IT TO THE... graphic analysis was polished using diamond incrusted polishing pads. The polished sample was imaged using a Zeiss Stereo Discovery V20 mi- croscope

  19. Core Competencies in Integrative Pain Care for Entry-Level Primary Care Physicians.

    Tick, Heather; Chauvin, Sheila W; Brown, Michael; Haramati, Aviad


    The objective was to develop a set of core competencies for graduating primary care physicians in integrative pain care (IPC), using the Accreditation Council for Graduate Medical Education (ACGME) domains. These competencies build on previous work in competencies for integrative medicine, interprofessional education, and pain medicine and are proposed for inclusion in residency training. A task force was formed to include representation from various professionals who are involved in education, research, and the practice of IPC and who represent broad areas of expertise. The task force convened during a 1.5-day face-to-face meeting, followed by a series of surveys and other vetting processes involving diverse interprofessional groups, which led to the consensus of a final set of competencies. The proposed competencies focus on interprofessional knowledge, skills, and attitudes (KSAs) and are in line with recommendations by the Institute of Medicine, military medicine, and professional pain societies advocating the need for coordination and integration of services for effective pain care with reduced risk and cost and improved outcomes. These ACGME domain compatible competencies for physicians reflect the contributions of several disciplines that will need to be included in evolving interprofessional settings and underscore the need for collaborative care. These core competencies can guide the incorporation of KSAs within curricula. The learning experiences should enable medical educators and graduating primary care physicians to focus more on integrative approaches, interprofessional team-based, patient-centered care that use evidence-based, traditional and complementary disciplines and therapeutics to provide safe and effective treatments for people in pain. Wiley Periodicals, Inc.

  20. Core Handling and Real-Time Non-Destructive Characterization at the Kochi Core Center: An Example of Core Analysis from the Chelungpu Fault

    W. Lin


    Full Text Available As an example of core analysis carried out inactive fault drilling programs, we report the procedures of core handling on the drilling site and non-destructive characterization in the laboratory. This analysis was employed onthe core samples taken from HoleBof the Taiwan Chelungpu-fault Drilling Project (TCDP, which penetrated through the active fault that slipped during the 1999 Chi-Chi, Taiwan earthquake. We show results of the non-destructive physical property measurements carried out at the Kochi Core Center (KCC, Japan. Distinct anomalies of lower bulk density and higher magnetic susceptibilitywere recognized in all three fault zones encountered in HoleB. To keep the core samples in good condition before they are used for variousanalyses is crucial. In addition, careful planning for core handlingand core analyses is necessary for successfulinvestigations. doi:10.2204/

  1. Comparative analysis of the core inflation for Russia

    A. K. Sapova


    Full Text Available Consumer price index is a measure of inflation and it consists of two parts: persistent component (trend inflation and short-term shocks. Inflation targeting requires index of core inflation, that independent from shortterm shocks and demonstrates the changes of the trend inflation. Reserve Banks pay attention on the changes in the trend inflation, when they take decisions about monetary policy, because it’s more informative than consumer price index for estimation of medium-term inflation risks. The objective of this article is detecting the index of core inflation that could be appropriate for monetary policy. There are some different measures of core inflation based on practice of Reserve Banks from different countries and economic articles. The comparative analysis presented in this article is based on several types of tests. The result of the research is that core consumer price index that is used today has got both advantages and weaknesses. Moreover, there is index of core inflation based on new methodology that is better than core consumer price index of Federal Sate Statistics Service. It is concluded that the Central Bank should focus precisely on this indicator when it takes decisions about monetary policy.

  2. Family size in primary trisonic analysis

    Romagosa, Ignacio


    [EN] In the planning of any genetic experiment the minimum family size should be determined in order to minimize the total efforts, while fulfilling the objectives of the experiment. In the present study, the family size has been determined for different methods and extra chromosome transmission rates in primary trisomic analysis. The statistical criterion used was the "minimax" solution. Tables for both F2 and backcross generation for different transmission rates and type of trisomic inheri...

  3. Use of bone core biopsies for cytogenetic analysis

    Martin, P.; Rowley, J.D.; Baron, J.M.


    Cultures of bone core specimens have proved satisfactory for cytogenetic analysis in patients from whom it was impossible to obtain a bone marrow aspirate, or in whose peripheral blood dividing myeloid cells were absent or insufficient in number. The quality of the metaphase chromosome is adequate for banding studies.

  4. Stress analysis of portable safety platform (Core Sampler Truck)

    Ziada, H.H.


    This document provides the stress analysis and evaluation of the portable platform of the rotary mode core sampler truck No. 2 (RMCST {number_sign}2). The platform comprises railing, posts, deck, legs, and a portable ladder; it is restrained from lateral motion by means of two brackets added to the drill-head service platform.

  5. The features of Drosophila core promoters revealed by statistical analysis

    Trifonov Edward N


    Full Text Available Abstract Background Experimental investigation of transcription is still a very labor- and time-consuming process. Only a few transcription initiation scenarios have been studied in detail. The mechanism of interaction between basal machinery and promoter, in particular core promoter elements, is not known for the majority of identified promoters. In this study, we reveal various transcription initiation mechanisms by statistical analysis of 3393 nonredundant Drosophila promoters. Results Using Drosophila-specific position-weight matrices, we identified promoters containing TATA box, Initiator, Downstream Promoter Element (DPE, and Motif Ten Element (MTE, as well as core elements discovered in Human (TFIIB Recognition Element (BRE and Downstream Core Element (DCE. Promoters utilizing known synergetic combinations of two core elements (TATA_Inr, Inr_MTE, Inr_DPE, and DPE_MTE were identified. We also establish the existence of promoters with potentially novel synergetic combinations: TATA_DPE and TATA_MTE. Our analysis revealed several motifs with the features of promoter elements, including possible novel core promoter element(s. Comparison of Human and Drosophila showed consistent percentages of promoters with TATA, Inr, DPE, and synergetic combinations thereof, as well as most of the same functional and mutual positions of the core elements. No statistical evidence of MTE utilization in Human was found. Distinct nucleosome positioning in particular promoter classes was revealed. Conclusion We present lists of promoters that potentially utilize the aforementioned elements/combinations. The number of these promoters is two orders of magnitude larger than the number of promoters in which transcription initiation was experimentally studied. The sequences are ready to be experimentally tested or used for further statistical analysis. The developed approach may be utilized for other species.

  6. The Healthy Core Metabolism: A New Paradigm for Primary Preventive Nutrition.

    Fardet, A; Rock, E


    Research in preventive nutrition aims at elucidating mechanism by which our diet helps us to remain in good health through optimal physiological functions. However, despite decades of accumulated data in human nutrition and regular subsequent nutritional recommendations, obesity and type 2 diabetes epidemics continue to progress worldwide each year leading to a regular decrease of the Healthy Life Years, notably in Western countries. Such a paradox may be explained by the Nutrition Transition, the extreme application of the reductionist paradigm in nutrition research, the lack of nutritional education and a too strong focus on curative nutrition in at risk/ill subjects. In this position paper, we hypothesized that researchers should focus more on healthy subjects, from birth until maturity. Rather than exploring what differentiates healthy and at risk/ill subjects, we propose to thoroughly study what characterizes a healthy state and its underlying metabolism. We define it as the Healthy Core Metabolism which remains stable whatever energy inputs (diets) and outputs (exercise), genetic background and external/internal stress, e.g., temporary illnesses. As a basis for Healthy Core Metabolism investigation, we observed that main physiological and ubiquitous functions of human organism, i.e., the neuro-vasculo-sarco-osteoporotic system, tend to follow a concave curve with common phases of growth, optimum, and decline. Finally, we hypothesized that true primary preventive nutrition should focus on the growth phase to reach the maximum capital of a given physiological function so that - whatever the further decline -, Healthy Life Years may approach or coincide with theoretical Life Expectancy.

  7. Magnetic resonance imaging in laboratory petrophysical core analysis

    Mitchell, J.; Chandrasekera, T. C.; Holland, D. J.; Gladden, L. F.; Fordham, E. J.


    Magnetic resonance imaging (MRI) is a well-known technique in medical diagnosis and materials science. In the more specialized arena of laboratory-scale petrophysical rock core analysis, the role of MRI has undergone a substantial change in focus over the last three decades. Initially, alongside the continual drive to exploit higher magnetic field strengths in MRI applications for medicine and chemistry, the same trend was followed in core analysis. However, the spatial resolution achievable in heterogeneous porous media is inherently limited due to the magnetic susceptibility contrast between solid and fluid. As a result, imaging resolution at the length-scale of typical pore diameters is not practical and so MRI of core-plugs has often been viewed as an inappropriate use of expensive magnetic resonance facilities. Recently, there has been a paradigm shift in the use of MRI in laboratory-scale core analysis. The focus is now on acquiring data in the laboratory that are directly comparable to data obtained from magnetic resonance well-logging tools (i.e., a common physics of measurement). To maintain consistency with well-logging instrumentation, it is desirable to measure distributions of transverse (T2) relaxation time-the industry-standard metric in well-logging-at the laboratory-scale. These T2 distributions can be spatially resolved over the length of a core-plug. The use of low-field magnets in the laboratory environment is optimal for core analysis not only because the magnetic field strength is closer to that of well-logging tools, but also because the magnetic susceptibility contrast is minimized, allowing the acquisition of quantitative image voxel (or pixel) intensities that are directly scalable to liquid volume. Beyond simple determination of macroscopic rock heterogeneity, it is possible to utilize the spatial resolution for monitoring forced displacement of oil by water or chemical agents, determining capillary pressure curves, and estimating

  8. Code Coupling for Multi-Dimensional Core Transient Analysis

    Park, Jin-Woo; Park, Guen-Tae; Park, Min-Ho; Ryu, Seok-Hee; Um, Kil-Sup; Lee Jae-Il [KEPCO NF, Daejeon (Korea, Republic of)


    After the CEA ejection, the nuclear power of the reactor dramatically increases in an exponential behavior until the Doppler effect becomes important and turns the reactivity balance and power down to lower levels. Although this happens in a very short period of time, only few seconds, the energy generated can be very significant and cause fuel failures. The current safety analysis methodology which is based on overly conservative assumptions with the point kinetics model results in quite adverse consequences. Thus, KEPCO Nuclear Fuel(KNF) is developing the multi-dimensional safety analysis methodology to mitigate the consequences of the single CEA ejection accident. For this purpose, three-dimensional core neutron kinetics code ASTRA, sub-channel analysis code THALES, and fuel performance analysis code FROST, which have transient calculation performance, were coupled using message passing interface (MPI). This paper presents the methodology used for code coupling and the preliminary simulation results with the coupled code system (CHASER). Multi-dimensional core transient analysis code system, CHASER, has been developed and it was applied to simulate a single CEA ejection accident. CHASER gave a good prediction of multi-dimensional core transient behaviors during transient. In the near future, the multi-dimension CEA ejection analysis methodology using CHASER is planning to be developed. CHASER is expected to be a useful tool to gain safety margin for reactivity initiated accidents (RIAs), such as a single CEA ejection accident.

  9. Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease

    John P. McGahan


    liver and to define methods for improvement of diagnosis of primary liver tumors. Methods. This include retrospective study of 189 biopsies of 185 liver masses for cytological or histological analysis. Patients were subdivided into two groups. Group 1 consisted of 124 suspected metastasis. Group 2 consisted of 61 suspected primary neoplasms. Biopsies were considered positive or equivocal. In equivocal cases, special stains were performed. In Group 2, cases were classified by contrast CT or MRI as to (I classic HCC, (II infiltrated HCC, or (Ill equivocal. Results. Definitive diagnosis was obtained in 117/124 masses (94% in Group 1, 48/61 masses (79% in Group 2, and (Ill equivocal 13 cases in Group II. In two equivocal cases in which special stains were performed, they were reclassified as HCC. In 8/13 cases, CT findings were consistent with HCC. Conclusion. Liver biopsies are useful in obtaining a definitive diagnosis of suspected metastatic liver disease. Biopsy results are less reliable in patients with suspected primary liver tumors. In these situations, strategies can include basing treatment on imaging criteria or use of newer special pathological stains. Advances in Knowledge. Use of newer special immunological stains improves accuracy in definitive diagnosis of primary liver tumors.

  10. Size analysis of single-core magnetic nanoparticles

    Ludwig, Frank; Balceris, Christoph; Viereck, Thilo; Posth, Oliver; Steinhoff, Uwe; Gavilan, Helena; Costo, Rocio; Zeng, Lunjie; Olsson, Eva; Jonasson, Christian; Johansson, Christer


    Single-core iron-oxide nanoparticles with nominal core diameters of 14 nm and 19 nm were analyzed with a variety of non-magnetic and magnetic analysis techniques, including transmission electron microscopy (TEM), dynamic light scattering (DLS), static magnetization vs. magnetic field (M-H) measurements, ac susceptibility (ACS) and magnetorelaxometry (MRX). From the experimental data, distributions of core and hydrodynamic sizes are derived. Except for TEM where a number-weighted distribution is directly obtained, models have to be applied in order to determine size distributions from the measurand. It was found that the mean core diameters determined from TEM, M-H, ACS and MRX measurements agree well although they are based on different models (Langevin function, Brownian and Néel relaxation times). Especially for the sample with large cores, particle interaction effects come into play, causing agglomerates which were detected in DLS, ACS and MRX measurements. We observed that the number and size of agglomerates can be minimized by sufficiently strong diluting the suspension.

  11. Optimization Design and Finite Element Analysis of Core Cutter

    CAO Pin-lu; YIN Kun; PENG Jian-ming; LIU Jian-lin


    The hydro-hammer sampler is a new type of sampler compared with traditional ones. An important part of this new offshore sampler is that the structure of the core cutter has a significant effect on penetration and core recovery. In our experiments, a commercial finite element code with a capability of simulating large-strain frictional contact between two or more solid bodies is used to simulate the core cutter-soil interaction. The effects of the cutting edge shape, the diameter and the edge angle on penetration are analyzed by non-liner transient dynamic analysis using a finite element method (FEM). Simulation results show that the cutter shape clearly has an effect on the penetration and core recovery. In addition, the penetration of the sampler increases with an increase in the inside diameter of the cutter, but decreases with an increase in the cutting angle. Based on these analyses, an optimum structure of the core cutter is designed and tested in the north margin of the Dalian gulf. Experiment results show that the penetration rate is about 16.5 m/h in silty clay and 15.4 m/h in cohesive clay, while the recovery is 68% and 83.3% respectively.

  12. Degraded core analysis for the pressurized-water reactor

    Gittus, J.H.


    An analysis of the likelihood and the consequences of 'degraded-core accidents' has been undertaken for the proposed Sizewell B PWR. In such accidents, degradation of the core geometry occurs as a result of overheating. Radionuclides are released and may enter the environment, causing harmful effects. The analysis concludes that degraded-core accidents are highly improbable, the plant having been designed to reduce the frequency of such accidents to a value of order 10/sup -6/ per year. Tbe building containing the reactor would only fail in a small proportion of degraded-core accidents. In the great majority of cases the containment would remain intact and the release of radioactivity to the environment would be small. The risk to individuals have been calculated for both immediate and long term effects. Although the estimates of risk are approximate, studies to investigate the uncertainties, and sensitivities to different assumptions, show that potential errors are small compared with the very large 'margin of safety' between the risks estimated for Sizewell B and those that already exist in society.

  13. High Resolution Continuous Flow Analysis System for Polar Ice Cores

    Dallmayr, Remi; Azuma, Kumiko; Yamada, Hironobu; Kjær, Helle Astrid; Vallelonga, Paul; Azuma, Nobuhiko; Takata, Morimasa


    In the last decades, Continuous Flow Analysis (CFA) technology for ice core analyses has been developed to reconstruct the past changes of the climate system 1), 2). Compared with traditional analyses of discrete samples, a CFA system offers much faster and higher depth resolution analyses. It also generates a decontaminated sample stream without time-consuming sample processing procedure by using the inner area of an ice-core sample.. The CFA system that we have been developing is currently able to continuously measure stable water isotopes 3) and electrolytic conductivity, as well as to collect discrete samples for the both inner and outer areas with variable depth resolutions. Chemistry analyses4) and methane-gas analysis 5) are planned to be added using the continuous water stream system 5). In order to optimize the resolution of the current system with minimal sample volumes necessary for different analyses, our CFA system typically melts an ice core at 1.6 cm/min. Instead of using a wire position encoder with typical 1mm positioning resolution 6), we decided to use a high-accuracy CCD Laser displacement sensor (LKG-G505, Keyence). At the 1.6 cm/min melt rate, the positioning resolution was increased to 0.27mm. Also, the mixing volume that occurs in our open split debubbler is regulated using its weight. The overflow pumping rate is smoothly PID controlled to maintain the weight as low as possible, while keeping a safety buffer of water to avoid air bubbles downstream. To evaluate the system's depth-resolution, we will present the preliminary data of electrolytic conductivity obtained by melting 12 bags of the North Greenland Eemian Ice Drilling (NEEM) ice core. The samples correspond to different climate intervals (Greenland Stadial 21, 22, Greenland Stadial 5, Greenland Interstadial 5, Greenland Interstadial 7, Greenland Stadial 8). We will present results for the Greenland Stadial -8, whose depths and ages are between 1723.7 and 1724.8 meters, and 35.520 to


    Stoyanova, V; Linev, A; Ivanov, H; Vachev, T


    Primary amenorrhea is one of the common reproductive disorder affecting females. It leads to the absence of menarche in the reproductive age group in females and/or complete absence of reproductive organs. The physiology of menstruation and reproduction has a strong correlation with the expression of the X chromosome. Thus, the role of the clinical geneticists in terms of diagnosis, risk assessment, genetic counseling and management of patients with primary amenorrhea and their families is essential. The genetic contribution to amenorrhea is studied both at the cellular and molecular level aiming at chromosomal abnormalities and gene mutations. In the present study we aim to perform chromosomal analysis in 140 patients present with primary amenorrhea employing GTG banding technique. The resulting karyotype revealed 67.4% (n = 95) with normal chromosome composition and 32.6% (n = 46) showed chromosomal abnormalities. In patients with abnormal chromosome constituents, 20% (n = 9) exhibit numerical aberration, 22% (n = 10) showed structural abnormalities, 43% (n = 20) mosaic genotype and 15% (n = 7) of cases--male karyotype. Furthermore, the involvement of Y chromosome and the origin of marker chromosome was confirmed by applying fluorescent in situ hybridization (FISH) in four patients.

  15. Preliminary Core Analysis of a Micro Modular Reactor

    Jo, Chang Keun; Chang, Jongwa [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Venneri, Francesco [Ultra Safe Nuclear Corporation, Los Alamos (United States); Hawari, Ayman [NC State Univ., Raleigh (United States)


    The Micro Modular Reactor (MMR) will be 'melt-down proof'(MDP) under all circumstances, including the complete loss of coolant, and will be easily transportable and retrievable, and suitable for use with very little site preparation and Balance of Plant (BOP) requirements for a variety of applications, from power generation and process heat applications in remote areas to grid-unattached locations, including ship propulsion. The Micro Modular Reactor design proposed in this paper has 3 meter diameter core (2 meter active core) which is suitable for 'factory manufactured' and has few tens year of service life for remote deployment. We confirmed the feasibility of long term service life by a preliminary neutronic analysis in terms of the excess reactivity, the temperature feedback coefficient, and the control margins. We are able to achieve a reasonably long core life time of 5 ∼ 10 years under typical thermal hydraulic condition of a helium cooled reactor. However, on a situation where longer service period and safety is important, we can reduce the power density to the level of typical pebble bed reactor. In this case we can design 10 MWt MMR with core diameter for 10 ∼ 40 years core life time without much loss in the economics. Several burnable poisons are studied and it is found that erbia mixed in the compact matrix seems reasonably good poison. The temperature feedback coefficients were remaining negative during lifetime. Drum type control rods at reflector region and few control rods inside core region are sufficient to control the reactivity during operation and to achieve safe cold shutdown state.

  16. Dynamical analysis of innovative core designs facing unprotected transients with the MAT5 DYN code

    Darmet, G.; Massara, S. [EDF R and D, 1 avenue du general de Gaulle, 92140 Clamart (France)


    Since 2007, advanced Sodium-cooled Fast Reactors (SFR) are investigated by CEA, AREVA and EDF in the framework of a joint French collaboration. A prototype called ASTRID, sets out to demonstrate progress made in SFR technology, is due to operate in the years 2020's. The modeling of unprotected transients by computer codes is one of the key safety issues in the design approach to such SFR systems. For that purpose, the activity on CATHARE, which is the reference code for the transient analysis of ASTRID, has been strengthened during last years by CEA. In the meantime, EDF has developed a simplified and multi-channel code, named MAT5 DYN, to analyze and validate innovative core designs facing protected and unprotected transients. First, the paper consists in a description of MAT5 DYN: a code based on the existing code MAT4 DYN including major improvements on geometry description and physical modeling. Second, two core designs based on the CFV core design developed at CEA are presented. Then, the dynamic response of those heterogeneous cores is analyzed during unprotected loss of flow (ULOF) transient and unprotected transient of power (UTOP). The results highlight the importance of the low void core effect specific to the CFV design. Such an effect, when combined with a sufficient primary pump halving time and an optimized cooling group scheme, allows to delay (or, possibly, avoid) the sodium boiling onset during ULOF accidents. (authors)

  17. Analysis of the core genome and pangenome of Pseudomonas putida.

    Udaondo, Zulema; Molina, Lázaro; Segura, Ana; Duque, Estrella; Ramos, Juan L


    Pseudomonas putida are strict aerobes that proliferate in a range of temperate niches and are of interest for environmental applications due to their capacity to degrade pollutants and ability to promote plant growth. Furthermore solvent-tolerant strains are useful for biosynthesis of added-value chemicals. We present a comprehensive comparative analysis of nine strains and the first characterization of the Pseudomonas putida pangenome. The core genome of P. putida comprises approximately 3386 genes. The most abundant genes within the core genome are those that encode nutrient transporters. Other conserved genes include those for central carbon metabolism through the Entner-Doudoroff pathway, the pentose phosphate cycle, arginine and proline metabolism, and pathways for degradation of aromatic chemicals. Genes that encode transporters, enzymes and regulators for amino acid metabolism (synthesis and degradation) are all part of the core genome, as well as various electron transporters, which enable aerobic metabolism under different oxygen regimes. Within the core genome are 30 genes for flagella biosynthesis and 12 key genes for biofilm formation. Pseudomonas putida strains share 85% of the coding regions with Pseudomonas aeruginosa; however, in P. putida, virulence factors such as exotoxins and type III secretion systems are absent.

  18. Error Analysis of High Frequency Core Loss Measurement for Low-Permeability Low-Loss Magnetic Cores

    Niroumand, Farideh Javidi; Nymand, Morten


    in magnetic cores is B-H loop measurement where two windings are placed on the core under test. However, this method is highly vulnerable to phase shift error, especially for low-permeability, low-loss cores. Due to soft saturation and very low core loss, low-permeability low-loss magnetic cores are favorable....... The analysis has been validated by experimental measurements for relatively low-loss magnetic cores with different permeability values.......Magnetic components significantly contribute to the dissipated loss in power electronic converters. Measuring the true value of dissipated power in these components is highly desirable, since it can be used to verify the optimum design of these components. The common approach for measuring the loss...

  19. Multivariate Regression Analysis of Gravitational Waves from Rotating Core Collapse

    Engels, William J; Ott, Christian D


    We present a new multivariate regression model for analysis and parameter estimation of gravitational waves observed from well but not perfectly modeled sources such as core-collapse supernovae. Our approach is based on a principal component decomposition of simulated waveform catalogs. Instead of reconstructing waveforms by direct linear combination of physically meaningless principal components, we solve via least squares for the relationship that encodes the connection between chosen physical parameters and the principal component basis. Although our approach is linear, the waveforms' parameter dependence may be non-linear. For the case of gravitational waves from rotating core collapse, we show, using statistical hypothesis testing, that our method is capable of identifying the most important physical parameters that govern waveform morphology in the presence of simulated detector noise. We also demonstrate our method's ability to predict waveforms from a principal component basis given a set of physical ...

  20. Neutronic analysis of LMFBRs during severe core disruptive accidents

    Tomlinson, E.T.


    A number of numerical experiments were performed to assess the validity of diffusion theory and various perturbation methods for calculating the reactivity state of a severely disrupted liquid metal cooled fast breeder reactor (LMFBR). The disrupted configurations correspond, in general, to phases through which an LMFBR core could pass during a core disruptive accident (CDA). Two-reactor models were chosen for this study, the two zone, homogeneous Clinch River Breeder Reactor and the Large Heterogeneous Reactor Design Study Core. The various phases were chosen to approximate the CDA results predicted by the safety analysis code SAS3D. The calculational methods investigated in this study include the eigenvalue difference technique based on both discrete ordinate transport theory and diffusion theory, first-order perturbation theory, exact perturbation theory, and a new hybrid perturbation theory. Selected cases were analyzed using Monte Carlo methods. It was found that in all cases, diffusion theory and perturbation theory yielded results for the change in reactivity that significantly disagreed with both the discrete ordinate and Monte Carlo results. These differences were, in most cases, in a nonconservative direction.

  1. Uncommon primary tumors of the orbit diagnosed by computed tomography-guided core needle biopsy: report of two cases

    Tyng, Chiang Jeng; Matushita Junior, Joao Paulo Kawaoka; Bitencourt, Almir Galvao Vieira; Amoedo, Mauricio Kauark; Barbosa, Paula Nicole Vieira; Chojniak, Rubens, E-mail: [A.C.Camargo Cancer Center, Sao Paulo, SP (Brazil). Dept. de Imagem; Neves, Flavia Branco Cerqueira Serra [Hospital do Servidor Publico Estadual, Sao Paulo, SP (Brazil). Div. de Oftalmologia


    Computed tomography-guided percutaneous biopsy is a safe and effective alternative method for evaluating selected intra-orbital lesions where the preoperative diagnosis is important for the therapeutic planning. The authors describe two cases of patients with uncommon primary orbital tumors whose diagnosis was obtained by means of computed tomography-guided core needle biopsy, with emphasis on the technical aspects of the procedure. (author)

  2. Computation system for nuclear reactor core analysis. [LMFBR

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W.; Petrie, L.M.


    This report documents a system which contains computer codes as modules developed to evaluate nuclear reactor core performance. The diffusion theory approximation to neutron transport may be applied with the VENTURE code treating up to three dimensions. The effect of exposure may be determined with the BURNER code, allowing depletion calculations to be made. The features and requirements of the system are discussed and aspects common to the computational modules, but the latter are documented elsewhere. User input data requirements, data file management, control, and the modules which perform general functions are described. Continuing development and implementation effort is enhancing the analysis capability available locally and to other installations from remote terminals.

  3. Eigenvalue analysis using a full-core Monte Carlo method

    Okafor, K.C.; Zino, J.F. (Westinghouse Savannah River Co., Aiken, SC (United States))


    The reactor physics codes used at the Savannah River Site (SRS) to predict reactor behavior have been continually benchmarked against experimental and operational data. A particular benchmark variable is the observed initial critical control rod position. Historically, there has been some difficulty predicting this position because of the difficulties inherent in using computer codes to model experimental or operational data. The Monte Carlo method is applied in this paper to study the initial critical control rod positions for the SRS K Reactor. A three-dimensional, full-core MCNP model of the reactor was developed for this analysis.

  4. HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

    Yamamoto Sohei


    Full Text Available Abstract Background Accurate evaluation of human epidermal growth factor receptor type-2 (HER2 status based on core needle biopsy (CNB specimens is mandatory for identification of patients with primary breast cancer who will benefit from primary systemic therapy with trastuzumab. The aim of the present study was to validate the application of HER2 testing with CNB specimens from primary breast cancers in terms of interobserver reproducibility and comparison with surgically resected specimens. Methods A total of 100 pairs of archival formalin-fixed paraffin-embedded CNB and surgically resected specimens of invasive breast carcinomas were cut into sections. All 100 paired sections were subjected to HER2 testing by immunohistochemistry (IHC and 27 paired sections were subjected to that by fluorescence in situ hybridization (FISH, the results being evaluated by three and two observers, respectively. Interobserver agreement levels in terms of judgment and the concordance of consensus scores between CNB samples and the corresponding surgically resected specimens were estimated as the percentage agreement and κ statistic. Results In CNB specimens, the percentage interobserver agreement of HER2 scoring by IHC was 76% (κ = 0.71 for 3 × 3 categories (0-1+ versus 2+ versus 3+ and 90% (κ = 0.80 for 2 × 2 categories (0-2+ versus 3+. These levels were close to the corresponding ones for the surgically resected specimens: 80% (κ = 0.77 for 3 × 3 categories and 92% (κ = 0.88 for 2 × 2 categories. Concordance of consensus for HER2 scores determined by IHC between CNB and the corresponding surgical specimens was 87% (κ = 0.77 for 3 × 3 categories, and 94% (κ = 0.83 for 2 × 2 categories. Among the 13 tumors showing discordance in the mean IHC scores between the CNB and surgical specimens, the results of consensus for FISH results were concordant in 11. The rate of successful FISH analysis and the FISH positivity rate in cases with a HER2 IHC score of

  5. Analysis of three-phase power transformer laminated magnetic core designs

    M.I. Levin


    Full Text Available Analysis and research into properties and parameters of different-type laminated magnetic cores of three-phase power transformers are conducted. Most of new laminated magnetic core designs are found to have significant shortcomings resulted from design and technological features of their manufacturing. These shortcomings cause increase in ohmic loss in the magnetic core, which eliminates advantages of the new core configurations and makes them uncompetitive as compared with the classical laminated magnetic core design.

  6. Transient Analysis of Air-Core Coils by Moment Method

    Fujita, Akira; Kato, Shohei; Hirai, Takao; Okabe, Shigemitu

    In electric power system a threat of lighting surge is decreased by using ground wire and arrester, but the risk of failure of transformer is still high. Winding is the most familiar conductor configuration of electromagnetic field components such as transformer, resistors, reactance device etc. Therefore, it is important that we invest the lighting surge how to advance into winding, but the electromagnet coupling in a winding makes lighting surge analysis difficult. In this paper we present transient characteristics analysis of an air-core coils by moment method in frequency domain. We calculate the inductance from time response and impedance in low frequency, and compare them with the analytical equation which is based on Nagaoka factor.

  7. Developing engineering design core competences through analysis of industrial products

    Hansen, Claus Thorp; Lenau, Torben Anker


    Most product development work carried out in industrial practice is characterised by being incremental, i.e. the industrial company has had a product in production and on the market for some time, and now time has come to design a new and upgraded variant. This type of redesign project requires...... that the engineering designers have core design competences to carry through an analysis of the existing product encompassing both a user-oriented side and a technical side, as well as to synthesise solution proposals for the new and upgraded product. The authors of this paper see an educational challenge in staging...... a course module, in which students develop knowledge, understanding and skills, which will prepare them for being able to participate in and contribute to redesign projects in industrial practice. In the course module Product Analysis and Redesign that has run for 8 years we have developed and refined...

  8. Development and validation of a microRNA based diagnostic assay for primary tumor site classification of liver core biopsies

    Perell, Katharina; Vincent, Martin; Vainer, Ben;


    negatively affect the accuracy and usability of molecular classifiers. We have developed and validated a microRNA-based classifier, which predicts the primary tumor site of liver biopsies, containing a limited number of tumor cells. Concurrently we explored the influence of surrounding normal tissue...... for normal liver tissue contamination. Performance was estimated by cross-validation, followed by independent validation on 55 liver core biopsies with a tumor content as low as 10%. A microRNA classifier developed, using the statistical contamination model, showed an overall classification accuracy of 74...... on classification. MicroRNA profiling was performed using quantitative Real-Time PCR on formalin-fixed paraffin-embedded samples. 278 primary tumors and liver metastases, representing nine primary tumor classes, as well as normal liver samples were used as a training set. A statistical model was applied to adjust...

  9. The breadth of primary care: a systematic literature review of its core dimensions.

    Kringos, D.S.; Boerma, W.G.W.; Hutchinson, A.; Zee, J. van der; Groenewegen, P.P.


    BACKGROUND: Even though there is general agreement that primary care is the linchpin of effective health care delivery, to date no efforts have been made to systematically review the scientific evidence supporting this supposition. The aim of this study was to examine the breadth of primary care by

  10. The CoRe of the Matter: Developing Primary Teachers' Professional Knowledge in Science

    Hume, Anne


    In an educational landscape of primary teachers' underdeveloped professional knowledge and low feelings of self-efficacy around science teaching, the prospects for science losing status in the primary school curriculum seems grim. This paper reports positive findings from a New Zealand research project designed to support and enhance primary…

  11. Core Stability in Athletes: A Critical Analysis of Current Guidelines.

    Wirth, Klaus; Hartmann, Hagen; Mickel, Christoph; Szilvas, Elena; Keiner, Michael; Sander, Andre


    Over the last two decades, exercise of the core muscles has gained major interest in professional sports. Research has focused on injury prevention and increasing athletic performance. We analyzed the guidelines for so-called functional strength training for back pain prevention and found that programs were similar to those for back pain rehabilitation; even the arguments were identical. Surprisingly, most exercise specifications have neither been tested for their effectiveness nor compared with the load specifications normally used for strength training. Analysis of the scientific literature on core stability exercises shows that adaptations in the central nervous system (voluntary activation of trunk muscles) have been used to justify exercise guidelines. Adaptations of morphological structures, important for the stability of the trunk and therefore the athlete's health, have not been adequately addressed in experimental studies or in reviews. In this article, we explain why the guidelines created for back pain rehabilitation are insufficient for strength training in professional athletes. We critically analyze common concepts such as 'selective activation' and training on unstable surfaces.

  12. Deconvolution-based resolution enhancement of chemical ice core records obtained by continuous flow analysis

    Rasmussen, Sune Olander; Andersen, Katrine K.; Johnsen, Sigfus Johann;


    Continuous flow analysis (CFA) has become a popular measuring technique for obtaining high-resolution chemical ice core records due to an attractive combination of measuring speed and resolution. However, when analyzing the deeper sections of ice cores or cores from low-accumulation areas, there ...

  13. Technique for continuous high-resolution analysis of trace substances in firn and ice cores

    Roethlisberger, R.; Bigler, M.; Hutterli, M.; Sommer, S.; Stauffer, B.; Junghans, H.G.; Wagenbach, D.


    The very successful application of a CFA (Continuous flow analysis) system in the GRIP project (Greenland Ice Core Project) for high-resolution ammonium, calcium, hydrogen peroxide, and formaldehyde measurements along a deep ice core led to further development of this analysis technique. The authors included methods for continuous analysis technique. The authors included methods for continuous analysis of sodium, nitrate, sulfate, and electrolytical conductivity, while the existing methods have been improved. The melting device has been optimized to allow the simultaneous analysis of eight components. Furthermore, a new melter was developed for analyzing firn cores. The system has been used in the frame of the European Project for Ice Coring in Antarctica (EPICA) for in-situ analysis of several firn cores from Dronning Maud Land, Antarctica, and for the new ice core drilled at Dome C, Antarctica.

  14. Finite element stress analysis of short-post core and over restorations prepared with different restorative materials.

    Gurbuz, Taskin; Sengul, Fatih; Altun, Ceyhan


    The present study was conducted to determine the effect on the distribution of stress with the use of short-post cores and over restorations composed of different materials. The restorative materials used were namely two different composite resin materials (Valux Plus and Tetric Flow), a polyacid-modified resin material (Dyract AP), and a woven polyethylene fiber combination (Ribbond Fiber + Bonding agent + Tetric Flow). Finite element analysis (FEA) was used to develop a model for the maxillary primary anterior teeth. A masticatory force of 100 N was applied at 148 degrees to the incisal edge of the palatal surface of the crown model. Stress distributions and stress values were compared using von Mises criteria. The tooth model was assumed to be isotropic, homogeneous, elastic, and asymmetrical. It was observed that the highest stress usually occurred in the cervical area of the tooth when Tetric Flow was used as the short-post core and over restoration material. The same maximum stress value was also obtained when Ribbond fiber + Tetric Flow material was used for the short-post core. The results of FEA showed that the mechanical properties and elastic modulus of the restorative material influenced the stresses generated in enamel, dentin, and restoration when short-post core restorations were loaded incisally. Resin-based restorative materials with higher elastic moduli were found to be unsuitable as short-post core materials in endodontically treated maxillary primary anterior teeth.

  15. Earth's core and inner-core resonances from analysis of VLBI nutation and superconducting gravimeter data

    Rosat, S.; Lambert, S. B.; Gattano, C.; Calvo, M.


    Geophysical parameters of the deep Earth's interior can be evaluated through the resonance effects associated with the core and inner-core wobbles on the forced nutations of the Earth's figure axis, as observed by very long baseline interferometry (VLBI), or on the diurnal tidal waves, retrieved from the time-varying surface gravity recorded by superconducting gravimeters (SGs). In this paper, we inverse for the rotational mode parameters from both techniques to retrieve geophysical parameters of the deep Earth. We analyse surface gravity data from 15 SG stations and VLBI delays accumulated over the last 35 yr. We show existing correlations between several basic Earth parameters and then decide to inverse for the rotational modes parameters. We employ a Bayesian inversion based on the Metropolis-Hastings algorithm with a Markov-chain Monte Carlo method. We obtain estimates of the free core nutation resonant period and quality factor that are consistent for both techniques. We also attempt an inversion for the free inner-core nutation (FICN) resonant period from gravity data. The most probable solution gives a period close to the annual prograde term (or S1 tide). However the 95 per cent confidence interval extends the possible values between roughly 28 and 725 d for gravity, and from 362 to 414 d from nutation data, depending on the prior bounds. The precisions of the estimated long-period nutation and respective small diurnal tidal constituents are hence not accurate enough for a correct determination of the FICN complex frequency.

  16. Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs

    Jin, Victor X.; Singer, Gregory AC; Agosto-Pérez, Francisco J; Liyanarachchi, Sandya; Davuluri, Ramana V.


    Background The canonical core promoter elements consist of the TATA box, initiator (Inr), downstream core promoter element (DPE), TFIIB recognition element (BRE) and the newly-discovered motif 10 element (MTE). The motifs for these core promoter elements are highly degenerate, which tends to lead to a high false discovery rate when attempting to detect them in promoter sequences. Results In this study, we have performed the first analysis of these core promoter elements in orthologous mouse a...

  17. Core Flow Distribution from Coupled Supercritical Water Reactor Analysis

    Po Hu


    Full Text Available This paper introduces an extended code package PARCS/RELAP5 to analyze steady state of SCWR US reference design. An 8 × 8 quarter core model in PARCS and a reactor core model in RELAP5 are used to study the core flow distribution under various steady state conditions. The possibility of moderator flow reversal is found in some hot moderator channels. Different moderator flow orifice strategies, both uniform across the core and nonuniform based on the power distribution, are explored with the goal of preventing the reversal.

  18. Buckling and dynamic analysis of drill strings for core sampling

    Ziada, H.H., Westinghouse Hanford


    This supporting document presents buckling and dynamic stability analyses of the drill strings used for core sampling. The results of the drill string analyses provide limiting operating axial loads and rotational speeds to prevent drill string failure, instability and drill bit overheating during core sampling. The recommended loads and speeds provide controls necessary for Tank Waste Remediation System (TWRS) programmatic field operations.

  19. Development and analysis of U-core switched reluctance machine

    Jæger, Rasmus; Nielsen, Simon Staal; Rasmussen, Peter Omand


    these disadvantages have been presented, but not all of them have been demonstrated practically. This paper presents a practical demonstration and assessment of a segmented U-core SRM, which copes with some of the disadvantages of the regular SRM. The U-core SRM has a segmented stator, with a short flux path...

  20. Self-Healing Many-Core Architecture: Analysis and Evaluation

    Arezoo Kamran


    Full Text Available More pronounced aging effects, more frequent early-life failures, and incomplete testing and verification processes due to time-to-market pressure in new fabrication technologies impose reliability challenges on forthcoming systems. A promising solution to these reliability challenges is self-test and self-reconfiguration with no or limited external control. In this work a scalable self-test mechanism for periodic online testing of many-core processor has been proposed. This test mechanism facilitates autonomous detection and omission of faulty cores and makes graceful degradation of the many-core architecture possible. Several test components are incorporated in the many-core architecture that distribute test stimuli, suspend normal operation of individual processing cores, apply test, and detect faulty cores. Test is performed concurrently with the system normal operation without any noticeable downtime at the application level. Experimental results show that the proposed test architecture is extensively scalable in terms of hardware overhead and performance overhead that makes it applicable to many-cores with more than a thousand processing cores.

  1. Study of core support barrel vibration monitoring using ex-core neutron noise analysis and fuzzy logic algorithm

    Christian, Robby; Song, Seon Ho [Nuclear and Quantum Engineering Department, Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Kang, Hyun Gook [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)


    The application of neutron noise analysis (NNA) to the ex-core neutron detector signal for monitoring the vibration characteristics of a reactor core support barrel (CSB) was investigated. Ex-core flux data were generated by using a nonanalog Monte Carlo neutron transport method in a simulated CSB model where the implicit capture and Russian roulette technique were utilized. First and third order beam and shell modes of CSB vibration were modeled based on parallel processing simulation. A NNA module was developed to analyze the ex-core flux data based on its time variation, normalized power spectral density, normalized cross-power spectral density, coherence, and phase differences. The data were then analyzed with a fuzzy logic module to determine the vibration characteristics. The ex-core neutron signal fluctuation was directly proportional to the CSB's vibration observed at 8Hz and15Hzin the beam mode vibration, and at 8Hz in the shell mode vibration. The coherence result between flux pairs was unity at the vibration peak frequencies. A distinct pattern of phase differences was observed for each of the vibration models. The developed fuzzy logic module demonstrated successful recognition of the vibration frequencies, modes, orders, directions, and phase differences within 0.4 ms for the beam and shell mode vibrations.

  2. Homogeneous protein analysis by magnetic core-shell nanorod probes

    Schrittwieser, Stefan


    Studying protein interactions is of vital importance both to fundamental biology research and to medical applications. Here, we report on the experimental proof of a universally applicable label-free homogeneous platform for rapid protein analysis. It is based on optically detecting changes in the rotational dynamics of magnetically agitated core-shell nanorods upon their specific interaction with proteins. By adjusting the excitation frequency, we are able to optimize the measurement signal for each analyte protein size. In addition, due to the locking of the optical signal to the magnetic excitation frequency, background signals are suppressed, thus allowing exclusive studies of processes at the nanoprobe surface only. We study target proteins (soluble domain of the human epidermal growth factor receptor 2 - sHER2) specifically binding to antibodies (trastuzumab) immobilized on the surface of our nanoprobes and demonstrate direct deduction of their respective sizes. Additionally, we examine the dependence of our measurement signal on the concentration of the analyte protein, and deduce a minimally detectable sHER2 concentration of 440 pM. For our homogeneous measurement platform, good dispersion stability of the applied nanoprobes under physiological conditions is of vital importance. To that end, we support our measurement data by theoretical modeling of the total particle-particle interaction energies. The successful implementation of our platform offers scope for applications in biomarker-based diagnostics as well as for answering basic biology questions.




    On December 15-16, 2009, a 100-KE Reactor Core Removal Project Alternative Analysis Workshop was conducted at the Washington State University Consolidated Information Center, Room 214. Colburn Kennedy, Project Director, CH2M HILL Plateau Remediation Company (CHPRC) requested the workshop and Richard Harrington provided facilitation. The purpose of the session was to select the preferred Bio Shield Alternative, for integration with the Thermal Shield and Core Removal and develop the path forward to proceed with project delivery. Prior to this workshop, the S.A. Robotics (SAR) Obstruction Removal Alternatives Analysis (565-DLV-062) report was issued, for use prior to and throughout the session, to all the team members. The multidisciplinary team consisted ofrepresentatives from 100-KE Project Management, Engineering, Radcon, Nuclear Safety, Fire Protection, Crane/Rigging, SAR Project Engineering, the Department of Energy Richland Field Office, Environmental Protection Agency, Washington State Department of Ecology, Defense Nuclear Facility Safety Board, and Deactivation and Decommission subject matter experts from corporate CH2M HILL and Lucas. Appendix D contains the workshop agenda, guidelines and expectations, opening remarks, and attendance roster going into followed throughout the workshop. The team was successful in selecting the preferred alternative and developing an eight-point path forward action plan to proceed with conceptual design. Conventional Demolition was selected as the preferred alternative over two other alternatives: Diamond Wire with Options, and Harmonic Delamination with Conventional Demolition. The teams preferred alternative aligned with the SAR Obstruction Removal Alternative Analysis report conclusion. However, the team identified several Path Forward actions, in Appendix A, which upon completion will solidify and potentially enhance the Conventional Demolition alternative with multiple options and approaches to achieve project delivery

  4. High Temperature Stress Analysis on 61-pin Test Assembly for Reactor Core Sub-channel Flow Test

    Lee, Dongwon; Kim, Hyungmo; Lee, Hyeongyeon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    In this study, a high temperature heat transfer and stress analysis of a 61-pin test fuel assembly scaled down from the full scale 217-pin sub-assembly was conducted. The reactor core subchannel flow characteristic test will be conducted to evaluate uncertainties in computer codes used for reactor core thermal hydraulic design. Stress analysis for a 61-pin fuel assembly scaled down from Prototype Generation IV Sodium-cooled Fast Reactor was conducted and structural integrity in terms of load controlled stress limits was conducted. In this study, The evaluations on load-controlled stress limits for a 61-pin test fuel assembly to be used for reactor core subchannel flow distribution tests were conducted assuming that the test assembly is installed in a Prototype Generation IV Sodium-cooled fast reactor core. The 61-pin test assembly has the geometric similarity on P/D and H/D with PGSFR and material of fuel assembly is austenitic stainless steel 316L. The stress analysis results showed that 4.05MPa under primary load occurred at mid part of the test assembly and it was shown that the value of 4.05Mpa was far smaller than the code allowable of 127MPa. , it was shown that the stress intensity due to due to primary load is very small. The stress analysis results under primary and secondary loads showed that maximum stress intensity of 84.08MPa occurred at upper flange tangent to outer casing and the value was well within the code allowable of 268.8MPa. Integrity evaluations based on strain limits and creep-fatigue damage are underway according to the elevated design codes.

  5. Conversation Analysis (CA in Primary School Classrooms

    Alberto Fajardo


    Full Text Available Although CA deals with all kinds of talk produced in natural contexts, this study focuses its interest on the talk produced in some primary school classrooms. It attempts to develop the construct that CA should move significantly ahead to more practical grounds where its detailed and isolated description causes some effect in improving foreign language teaching, for example. It might be used, for instance, to promote professional development in Colombia. It plans to involve pre-service teachers initially and in-service ones later. The kind of interaction promoted by trainee teachers shows a very restricted possibility for young learners to use the language meaningfully in the classroom. Four stages are defined and suggested as a path to follow with pre-service teachers at Universidad Pedagógica y Tecnológica de Colombia –UPTC– in the Foreign Language Programme - FLP.

  6. Genetic diversity and population structure analysis to construct a core collection from a large Capsicum germplasm.

    Lee, Hea-Young; Ro, Na-Young; Jeong, Hee-Jin; Kwon, Jin-Kyung; Jo, Jinkwan; Ha, Yeaseong; Jung, Ayoung; Han, Ji-Woong; Venkatesh, Jelli; Kang, Byoung-Cheorl


    Conservation of genetic diversity is an essential prerequisite for developing new cultivars with desirable agronomic traits. Although a large number of germplasm collections have been established worldwide, many of them face major difficulties due to large size and a lack of adequate information about population structure and genetic diversity. Core collection with a minimum number of accessions and maximum genetic diversity of pepper species and its wild relatives will facilitate easy access to genetic material as well as the use of hidden genetic diversity in Capsicum. To explore genetic diversity and population structure, we investigated patterns of molecular diversity using a transcriptome-based 48 single nucleotide polymorphisms (SNPs) in a large germplasm collection comprising 3,821 accessions. Among the 11 species examined, Capsicum annuum showed the highest genetic diversity (HE = 0.44, I = 0.69), whereas the wild species C. galapagoense showed the lowest genetic diversity (HE = 0.06, I = 0.07). The Capsicum germplasm collection was divided into 10 clusters (cluster 1 to 10) based on population structure analysis, and five groups (group A to E) based on phylogenetic analysis. Capsicum accessions from the five distinct groups in an unrooted phylogenetic tree showed taxonomic distinctness and reflected their geographic origins. Most of the accessions from European countries are distributed in the A and B groups, whereas the accessions from Asian countries are mainly distributed in C and D groups. Five different sampling strategies with diverse genetic clustering methods were used to select the optimal method for constructing the core collection. Using a number of allelic variations based on 48 SNP markers and 32 different phenotypic/morphological traits, a core collection 'CC240' with a total of 240 accessions (5.2 %) was selected from within the entire Capsicum germplasm. Compared to the other core collections, CC240 displayed higher genetic

  7. Safety analysis for key design features of KALIMER with breakeven core

    Hahn, Do Hee; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, Y. B.; Jeong, K. S


    KAERI is currently developing the conceptual design of a liquid metal reactor, KALIMER (Korea Advanced Liquid MEtal Reactor) under the Long-term nuclear R and D Program. In this report, key safety design features are described and safety analyses results for typical ATWS accidents in the KALIMER design with breakeven core are presented. First, the basic approach to achieve the safety goal is introduced in chapter 1, and the event categorization and acceptance criteria for the KALIMER safety analysis are described in chapter 2. In chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. Safety analyses for the postulated anticipated transient without scram (ATWS) have been performed using the SSC-K code to investigate the KALIMER system response to the events. They are categorized as Bounding Events (BEs) because of their low probability of occurrence. In chapter 4, the performance analysis results of the KALIMER containment dome are described along with the HCDA accident scenario and source terms. The major containment parameters of peak pressure and peak temperature have been calculated using the CONTAIN-LMR code. Radiological consequence has been evaluated by the MACCS code. Finally, a simple methodology is introduced to investigate the core energetics behavior during HCDA in chapter 5. Sensitivity analyses have been performed for the KALIMER core behavior during super-prompt critical excursions, using SCHAMBETA code developed in the framework of the modified bethe-tait method. Work energy potentials based arising from the sodium expansion as well as the isentropic fuel expansion are then calculated to evaluate the structural integrity of the reactor vessel, reactor internals and primary coolant system of KALIMER.

  8. SUPERENERGY-2: a multiassembly, steady-state computer code for LMFBR core thermal-hydraulic analysis

    Basehore, K.L.; Todreas, N.E.


    Core thermal-hydraulic design and performance analyses for Liquid Metal Fast Breeder Reactors (LMFBRs) require repeated detailed multiassembly calculations to determine radial temperature profiles and subchannel outlet temperatures for various core configurations and subassembly structural analyses. At steady-state, detailed core-wide temperature profiles are required for core restraint calculations and subassembly structural analysis. In addition, sodium outlet temperatures are routinely needed for each reactor operating cycle. The SUPERENERGY-2 thermal-hydraulic code was designed specifically to meet these designer needs. It is applicable only to steady-state, forced-convection flow in LMFBR core geometries.

  9. Knowledge Economy Core Journals: Identification through LISTA Database Analysis.

    Nouri, Rasool; Karimi, Saeed; Ashrafi-rizi, Hassan; Nouri, Azadeh


    Knowledge economy has become increasingly broad over the years and identification of core journals in this field can be useful for librarians in journal selection process and also for researchers to select their studies and finding Appropriate Journal for publishing their articles. Present research attempts to determine core journals of Knowledge Economy indexed in LISTA (Library and Information Science and Technology). The research method was bibliometric and research population include the journals indexed in LISTA (From the start until the beginning of 2011) with at least one article a bout "knowledge economy". For data collection, keywords about "knowledge economy"-were extracted from the literature in this area-have searched in LISTA by using title, keyword and abstract fields and also taking advantage of LISTA thesaurus. By using this search strategy, 1608 articles from 390 journals were retrieved. The retrieved records import in to the excel sheet and after that the journals were grouped and the Bradford's coefficient was measured for each group. Finally the average of the Bradford's coefficients were calculated and core journals with subject area of "Knowledge economy" were determined by using Bradford's formula. By using Bradford's scattering law, 15 journals with the highest publication rates were identified as "Knowledge economy" core journals indexed in LISTA. In this list "Library and Information update" with 64 articles was at the top. "ASLIB Proceedings" and "Serials" with 51 and 40 articles are next in rank. Also 41 journals were identified as beyond core that "Library Hi Tech" with 20 articles was at the top. Increased importance of knowledge economy has led to growth of production of articles in this subject area. So the evaluation of journals for ranking these journals becomes a very challenging task for librarians and generating core journal list can provide a useful tool for journal selection and also quick and easy access to information. Core

  10. Knowledge Economy Core Journals: Identification through LISTA Database Analysis

    Nouri, Rasool; Karimi, Saeed; Ashrafi-rizi, Hassan; Nouri, Azadeh


    Background Knowledge economy has become increasingly broad over the years and identification of core journals in this field can be useful for librarians in journal selection process and also for researchers to select their studies and finding Appropriate Journal for publishing their articles. Present research attempts to determine core journals of Knowledge Economy indexed in LISTA (Library and Information Science and Technology). Methods The research method was bibliometric and research popu...

  11. TREAT Transient Analysis Benchmarking for the HEU Core

    Kontogeorgakos, D. C. [Argonne National Lab. (ANL), Argonne, IL (United States); Connaway, H. M. [Argonne National Lab. (ANL), Argonne, IL (United States); Wright, A. E. [Argonne National Lab. (ANL), Argonne, IL (United States)


    This work was performed to support the feasibility study on the potential conversion of the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory from the use of high enriched uranium (HEU) fuel to the use of low enriched uranium (LEU) fuel. The analyses were performed by the GTRI Reactor Conversion staff at the Argonne National Laboratory (ANL). The objective of this study was to benchmark the transient calculations against temperature-limited transients performed in the final operating HEU TREAT core configuration. The MCNP code was used to evaluate steady-state neutronics behavior, and the point kinetics code TREKIN was used to determine core power and energy during transients. The first part of the benchmarking process was to calculate with MCNP all the neutronic parameters required by TREKIN to simulate the transients: the transient rod-bank worth, the prompt neutron generation lifetime, the temperature reactivity feedback as a function of total core energy, and the core-average temperature and peak temperature as a functions of total core energy. The results of these calculations were compared against measurements or against reported values as documented in the available TREAT reports. The heating of the fuel was simulated as an adiabatic process. The reported values were extracted from ANL reports, intra-laboratory memos and experiment logsheets and in some cases it was not clear if the values were based on measurements, on calculations or a combination of both. Therefore, it was decided to use the term “reported” values when referring to such data. The methods and results from the HEU core transient analyses will be used for the potential LEU core configurations to predict the converted (LEU) core’s performance.

  12. Event analysis in a primary substation

    Jaerventausta, P.; Paulasaari, H. [Tampere Univ. of Technology (Finland); Partanen, J. [Lappeenranta Univ. of Technology (Finland)


    The target of the project was to develop applications which observe the functions of a protection system by using modern microprocessor based relays. Microprocessor based relays have three essential capabilities: communication with the SCADA, the internal clock to produce time stamped event data, and the capability to register certain values during the fault. Using the above features some new functions for event analysis were developed in the project

  13. Analysis and Design of ITER 1 MV Core Snubber

    王海田; 李格


    The core snubber, as a passive protection device, can suppress arc current and absorb stored energy in stray capacitance during the electrical breakdown in accelerating electrodes of ITER NBI. In order to design the core snubber of ITER, the control parameters of the arc peak current have been firstly analyzed by the Fink-Baker-Owren (FBO) method, which are used for designing the DIIID 100 kV snubber. The B-H curve can be derived from the measured voltage and current waveforms, and the hysteresis loss of the core snubber can be derived using the revised parallelogram method. The core snubber can be a simplified representation as an equivalent parallel resistance and inductance, which has been neglected by the FBO method. A simulation code including the parallel equivalent resistance and inductance has been set up. The simulation and experiments result in dramatically large arc shorting currents due to the parallel inductance effect. The case shows that the core snubber utilizing the FBO method gives more compact design.

  14. Preliminary Uncertainty Analysis for SMART Digital Core Protection and Monitoring System

    Koo, Bon Seung; In, Wang Kee; Hwang, Dae Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The Korea Atomic Energy Research Institute (KAERI) developed on-line digital core protection and monitoring systems, called SCOPS and SCOMS as a part of SMART plant protection and monitoring system. SCOPS simplified the protection system by directly connecting the four RSPT signals to each core protection channel and eliminated the control element assembly calculator (CEAC) hardware. SCOMS adopted DPCM3D method in synthesizing core power distribution instead of Fourier expansion method being used in conventional PWRs. The DPCM3D method produces a synthetic 3-D power distribution by coupling a neutronics code and measured in-core detector signals. The overall uncertainty analysis methodology which is used statistically combining uncertainty components of SMART core protection and monitoring system was developed. In this paper, preliminary overall uncertainty factors for SCOPS/SCOMS of SMART initial core were evaluated by applying newly developed uncertainty analysis method

  15. Magnetic, Structural, and Particle Size Analysis of Single- and Multi-Core Magnetic Nanoparticles

    Ludwig, Frank; Kazakova, Olga; Barquin, Luis Fernandez


    We have measured and analyzed three different commercial magnetic nanoparticle systems, both multi-core and single-core in nature, with the particle (core) size ranging from 20 to 100 nm. Complementary analysis methods and same characterization techniques were carried out in different labs...... and the results are compared with each other. The presented results primarily focus on determining the particle size—both the hydrodynamic size and the individual magnetic core size—as well as magnetic and structural properties. The used analysis methods include transmission electron microscopy, static...... and dynamic magnetization measurements, and Mössbauer spectroscopy. We show that particle (hydrodynamic and core) size parameters can be determined from different analysis techniques and the individual analysis results agree reasonably well. However, in order to compare size parameters precisely determined...

  16. McCARD for Neutronics Design and Analysis of Research Reactor Cores

    Shim, Hyung Jin; Park, Ho Jin; Kwon, Soonwoo; Seo, Geon Ho; Hyo Kim, Chang


    McCARD is a Monte Carlo (MC) neutron-photon transport simulation code developed exclusively for the neutronics design and analysis of nuclear reactor cores. McCARD is equipped with the hierarchical modeling and scripting functions, the CAD-based geometry processing module, the adjoint-weighted kinetics parameter and source multiplication factor estimation modules as well as the burnup analysis capability for the neutronics design and analysis of both research and power reactor cores. This paper highlights applicability of McCARD for the research reactor core neutronics analysis, as demonstrated for Kyoto University Critical Assembly, HANARO, and YALINA.

  17. Analysis of the Gas Core Actinide Transmutation Reactor (GCATR)

    Clement, J. D.; Rust, J. H.


    Design power plant studies were carried out for two applications of the plasma core reactor: (1) As a breeder reactor, (2) As a reactor able to transmute actinides effectively. In addition to the above applications the reactor produced electrical power with a high efficiency. A reactor subsystem was designed for each of the two applications. For the breeder reactor, neutronics calculations were carried out for a U-233 plasma core with a molten salt breeding blanket. A reactor was designed with a low critical mass (less than a few hundred kilograms U-233) and a breeding ratio of 1.01. The plasma core actinide transmutation reactor was designed to transmute the nuclear waste from conventional LWR's. The spent fuel is reprocessed during which 100% of Np, Am, Cm, and higher actinides are separated from the other components. These actinides are then manufactured as oxides into zirconium clad fuel rods and charged as fuel assemblies in the reflector region of the plasma core actinide transmutation reactor. In the equilibrium cycle, about 7% of the actinides are directly fissioned away, while about 31% are removed by reprocessing.

  18. Analysis of N-16 concentration in primary cooling system of AP1000 power reactor

    Rohanda, Anis [Center for Reactor Technology and Nuclear Safety – BATAN Kawasan PUSPIPTEK Gd. No. 80 Serpong, Tangerang Selatan 15310 (Indonesia); Waris, Abdul [Physics Department of ITB, Indonesia (Indonesia)


    Nitrogen-16 (N-16) is one of the radiation safety parameter on the primary reactor system. The activation product, N-16, is the predominant contributor to the activity in the reactor coolant system during reactor operation. N-16 is activation product derived from activation of O-16 with fast neutron based on {sup 16}O(n,p){sup 16}N reaction. Thus study is needed and it performs to determine N-16 concentration in reactor coolant (primary coolant) in supporting radiation safety. One of the way is using analytical methode based on activation and redecay princip to obtain N-16 concentration. The analysis was performed on the configuration basis and operational of Westinghouse AP1000 power reactor in several monitoring points at coolant reactor system. The results of the calculation of N-16 concentration at the core outlet, reactor vessel outlet, pressurizer line, inlet and outlet of steam generators, primary pumps, reactor vessels inlet and core inlet are: 281, 257, 255, 250, 145, 142, 129 and 112 µCi/gram respectively. The results of analysis compared with AP1000 design control document as standard values. The verification showed very high accuracy comparation between analytical results and standard values.

  19. Discussion about modeling the effects of neutron flux exposure for nuclear reactor core analysis

    Vondy, D.R.


    Methods used to calculate the effects of exposure to a neutron flux are described. The modeling of the nuclear-reactor core history presents an analysis challenge. The nuclide chain equations must be solved, and some of the methods in use for this are described. Techniques for treating reactor-core histories are discussed and evaluated.

  20. Performance modeling and analysis of parallel Gaussian elimination on multi-core computers

    Fadi N. Sibai


    Full Text Available Gaussian elimination is used in many applications and in particular in the solution of systems of linear equations. This paper presents mathematical performance models and analysis of four parallel Gaussian Elimination methods (precisely the Original method and the new Meet in the Middle –MiM– algorithms and their variants with SIMD vectorization on multi-core systems. Analytical performance models of the four methods are formulated and presented followed by evaluations of these models with modern multi-core systems’ operation latencies. Our results reveal that the four methods generally exhibit good performance scaling with increasing matrix size and number of cores. SIMD vectorization only makes a large difference in performance for low number of cores. For a large matrix size (n ⩾ 16 K, the performance difference between the MiM and Original methods falls from 16× with four cores to 4× with 16 K cores. The efficiencies of all four methods are low with 1 K cores or more stressing a major problem of multi-core systems where the network-on-chip and memory latencies are too high in relation to basic arithmetic operations. Thus Gaussian Elimination can greatly benefit from the resources of multi-core systems, but higher performance gains can be achieved if multi-core systems can be designed with lower memory operation, synchronization, and interconnect communication latencies, requirements of utmost importance and challenge in the exascale computing age.

  1. Core influence on the frequency response analysis (FRA of power transformers through the finite element method

    D. L. Alvarez


    Full Text Available In this paper the influence of core parameters in Frequency Response Analysis is analyzed through the equivalent circuit impedance matrix of the transformer winding; the parameters of the circuit have been computed using the Finite Element Method. In order to appreciate the behavior of the iron core in comparison to the air core, the frequency dependence of resonances is calculated to show how the air core only influences the results at low frequencies. The core is modeled using a complex permeability, and the parameters of conductivity and permeability are varied to show their influence in the resonances, which turned out to be negligible. In order to explain this behavior, the eigenvalues of the inverse impedance matrix are calculated showing that they are similar for different values of conductivity and permeability. Finally, the magnetic flux inside and outside the core and its influence in the frequency response is studied.

  2. Supermode analysis of the 18-core photonic crystal fiber laser

    王远; 姚建铨; 郑一博; 温午麒; 陆颖; 王鹏


    The modal of 18-core photonic crystal fiber laser is discussed and calculated.And corresponding far-field distribution of the supermodes is given by Fresnel diffraction integral.For improving beam quality,the mode selection method based on the Talbot effect is introduced.The reflection coefficients are calculated,and the result shows that an in-phase supermode can be locked better at a large propagation distance.

  3. Analysis of White Dwarfs with Strange-Matter Cores

    Mathews, G J; O'Gorman, B; Lan, N Q; Zech, W; Otsuki, K; Weber, F


    We summarize masses and radii for a number of white dwarfs as deduced from a combination of proper motion studies, Hipparcos parallax distances, effective temperatures, and binary or spectroscopic masses. A puzzling feature of these data is that some stars appear to have radii which are significantly smaller than that expected for a standard electron-degenerate white-dwarf equations of state. We construct a projection of white-dwarf radii for fixed effective mass and conclude that there is at least marginal evidence for bimodality in the radius distribution forwhite dwarfs. We argue that if such compact white dwarfs exist it is unlikely that they contain an iron core. We propose an alternative of strange-quark matter within the white-dwarf core. We also discuss the impact of the so-called color-flavor locked (CFL) state in strange-matter core associated with color superconductivity. We show that the data exhibit several features consistent with the expected mass-radius relation of strange dwarfs. We identify ...

  4. Description and Analysis of Core Samples: The Lunar Experience

    McKay, David S.; Allton, Judith H.


    Although no samples yet have been returned from a comet, extensive experience from sampling another solar system body, the Moon, does exist. While, in overall structure, composition, and physical properties the Moon bears little resemblance to what is expected for a comet, sampling the Moon has provided some basic lessons in how to do things which may be equally applicable to cometary samples. In particular, an extensive series of core samples has been taken on the Moon, and coring is the best way to sample a comet in three dimensions. Data from cores taken at 24 Apollo collection stations and 3 Luna sites have been used to provide insight into the evolution of the lunar regolith. It is now well understood that this regolith is very complex and reflects gardening (stirring of grains by micrometeorites), erosion (from impacts and solar wind sputtering), maturation (exposure on the bare lunar surface to solar winds ions and micrometeorite impacts) and comminution of coarse grains into finer grains, blanket deposition of coarse-grained layers, and other processes. All of these processes have been documented in cores. While a cometary regolith should not be expected to parallel in detail the lunar regolith, it is possible that the upper part of a cometary regolith may include textural, mineralogical, and chemical features which reflect the original accretion of the comet, including a form of gardening. Differences in relative velocities and gravitational attraction no doubt made this accretionary gardening qualitatively much different than the lunar version. Furthermore, at least some comets, depending on their orbits, have been subjected to impacts of the uppermost surface by small projectiles at some time in their history. Consequently, a more recent post-accretional gardening may have occurred. Finally, for comets which approach the sun, large scale erosion may have occurred driven by gas loss. The uppermost material of these comets may reflect some of the features

  5. Informational Text and the Common Core: A Content Analysis of Three Basal Reading Programs

    Walters, Barbara A.


    The Common Core State Standards for English Language Arts (CCSS-ELA) will have a significant impact on what teachers teach and what primary students are supposed to be able to do (Bomer & Maloch, 2011). By the end of fourth grade, reading instruction should be evenly balanced between literary text and informational text (NGA Center and CCSSO,…

  6. Inherent safety analysis of the KALIMER under a LOFA with a reduced primary pump halving time

    Chang, W. P.; Kwon, Y. M.; Jeong, H. Y.; Suk, S. D.; Lee, Y. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The 600 MWe, pool-type, sodium-cooled, metallic fuel loaded KALIMER-600 (Korea Advanced LiquId MEtal Reactor, 600 MWe) has been conceptually designed with an emphasis on safety by self-regulating (inherent/intrinsic) negative reactivity feedback in the core. Its inherent safety under the ATWS (Anticipated Transient Without Scram) events was demonstrated in an earlier study. Initiating events of an HCDA (Hypothetical Core Disruptive Accident), however, also need to be analyzed for assessment of the margins in the current design. In this study, a hypothetical triple-fault accident, ULOF (Unprotected Loss Of Flow) with a reduced pump halving time, is investigated as an initiator of a core disruptive accident. A ULOF with insufficient primary pump inertia may cause core sodium boiling due to a power-to-flow mismatch. If the positive sodium reactivity resulting from this boiling is not compensated for by other intrinsic negative reactivity feedbacks, the resulting core power burst would challenge the fuel integrity. The present study focuses on determination of the limit of the pump inertia for assuring inherent reactivity feedback and behavior of the core after sodium boiling as well. Transient analyses are performed with the safety analysis code SSC-K, which now incorporates a new sodium boiling model. The results show that a halving time of more than 6.0 s does not allow sodium boiling even with very conservative assumptions. Boiling takes place for a halving time of 1.8 s, and its behavior can be predicted reasonably by the SSC-K

  7. Grain-size analysis of sediment cores collected in 2009 offshore from Palos Verdes, California

    U.S. Geological Survey, Department of the Interior — This part of the data release includes grain-size analysis of sediment cores collected in 2009 offshore of Palos Verdes, California. It is one of seven files...

  8. Analysis of suprathermal nuclear processes in the solar core plasma

    Voronchev, Victor T.; Nakao, Yasuyuki; Watanabe, Yukinobu


    A consistent model for the description of suprathermal processes in the solar core plasma naturally triggered by fast particles generated in exoergic nuclear reactions is formulated. This model, based on the formalism of in-flight reaction probability, operates with different methods of treating particle slow-down in the plasma, and allows for the influence of electron degeneracy and electron screening on processes in the matter. The model is applied to examine slowing-down of 8.7 MeV α-particles produced in the {}7{Li}(p,α )α reaction of the pp chain, and to analyze suprathermal processes in the solar CNO cycle induced by them. Particular attention is paid to the suprathermal {}14{{N}}{(α ,{{p}})}17{{O}} reaction unappreciated in standard solar model simulations. It is found that an appreciable non-standard (α ,p) nuclear flow due to this reaction appears in the matter and modifies running of the CNO cycle in ∼95% of the solar core region. In this region at R> 0.1{R}ȯ , normal branching of nuclear flow {}14{{N}}≤ftarrow {}17{{O}}\\to {(}18{{F}})\\to {}18{{O}} transforms to abnormal sequential flow {}14{{N}}\\to {}17{{O}}\\to {(}18{{F}})\\to {}18{{O}}, altering some element abundances. In particular, nuclear network calculations reveal that in the outer core the abundances of 17O and 18O isotopes can increase by a factor of 20 as compared with standard estimates. A conjecture is made that other CNO suprathermal (α ,p) reactions may also affect abundances of CNO elements, including those generating solar neutrinos.

  9. Skin conditions in primary care: an analysis of referral demand.

    Castillo-Arenas, E; Garrido, V; Serrano-Ortega, S


    Skin conditions are among the main reasons for seeking primary health care. Primary care physicians (PCPs) must diagnose skin conditions and determine their impact, and must therefore incorporate the relevant knowledge and skills into their education. The present study analyzes the reasons for primary care referral to dermatology (referral demand) as well as diagnostic agreement between PCPs and dermatologists informed by pathology where appropriate. Data were collected for 755 patients and 882 initial dermatology appointments from February 1, 2012 through April 30, 2012 following primary care referral. Data obtained included age, sex, occupation, reason for referral, primary care diagnosis, and dermatologic diagnosis. Statistical analysis of the data for each diagnosed condition identified frequency, reasons for referral, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the κ statistic for diagnostic agreement. The most common diagnoses were seborrheic keratosis, melanocytic nevus, actinic keratosis, and acne. The main reason for referral was diagnostic assessment (52.5%). For skin tumors, sensitivity of primary care diagnosis was 22.4%, specificity 94.7%, PPV 40.7%, and NPV 88.3%, with a κ of 0.211. For the more common diagnoses, primary care sensitivity was generally low and specificity high. According to our results, primary care physicians are better qualified to rule out a given skin condition in a patient (high specificity) than to establish an accurate clinical diagnosis (poor sensitivity). This suggests that knowledge and skills training should be organized for primary care physicians to improve management of skin conditions-especially skin cancer, because of its impact. A more responsive system would ensue, with shorter waiting lists and better health care. Copyright © 2013 Elsevier España, S.L. and AEDV. All rights reserved.

  10. Coupled-mode analysis for single-helix chiral fiber gratings with small core-offset

    Li Yang; Linlin Xue; Jue Su; Jingren Qian


    Using conventional coupled-mode theory,a set of coupled-mode equations are formulated for single-helix chiral fiber long-period gratings.A helical-core fiber is analyzed as an example.The analysis is simple in mathematical form and intuitive in physical concept.Based on the analysis,the polarization independence of mode coupling in special fiber gratings is revealed.The transmission characteristics of helical-core fibers are also simulated and discussed.

  11. Assessment of Student Skills for Critiquing Published Primary Scientific Literature Using a Primary Trait Analysis Scale

    Manuel F. Varela


    Full Text Available Instructor evaluation of progressive student skills in the analysis of primary literature is critical for the development of these skills in young scientists. Students in a senior or graduate-level one-semester course in Immunology at a Masters-level comprehensive university were assessed for abilities (primary traits to recognize and evaluate the following elements of a scientific paper: Hypothesis and Rationale, Significance, Methods, Results, Critical Thinking and Analysis, and Conclusions. We tested the hypotheses that average recognition scores vary among elements and that scores change with time differently by trait. Recognition scores (scaled 1 to 5, and differences in scores were analyzed using analysis of variance (ANOVA, regression, and analysis of covariance (ANCOVA (n = 10 papers over 103 days. By multiple comparisons testing, we found that recognition scores statistically fell into two groups: high scores (for Hypothesis and Rationale, Significance, Methods, and Conclusions and low scores (for Results and Critical Thinking and Analysis. Recognition scores only significantly changed with time (increased for Hypothesis and Rationale and Results. ANCOVA showed that changes in recognition scores for these elements were not significantly different in slope (F1,16 = 0.254, P = 0.621 but the Results trait was significantly lower in elevation (F1,17 = 12.456, P = 0.003. Thus, students improved with similar trajectories, but starting and ending with lower Results scores. We conclude that students have greatest difficulty evaluating Results and critically evaluating scientific validity. Our findings show extant student skills, and the significant increase in some traits shows learning. This study demonstrates that students start with variable recognition skills and that student skills may be learned at differential rates. Faculty can use these findings or the primary trait analysis scoring scale to focus on specific paper elements for which

  12. Analysis of Primary School Teachers' Opinions on Family Diversity

    Bosch, Alvaro Capano; Massonnier, Natalie; González Tornaría, Maria del L.


    This article aims to do an analysis based on the opinion of primary school teachers on family models that are different from the traditional nuclear family. We worked with 60 teachers from Montevideo and the metropolitan area. They answered the Questionnaire: Teachers' Opinion on Family Diversity (CIDF for its Spanish acronym) (Morgado,…

  13. Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

    T.H. Karlsen; A. Franke; E. Melum; A.. Kaser; J.R. Hov; T. Balschun; B.A. Lie; A. Bergquist; C. Schramm; T.J. Weismüller; D. Gotthardt; C. Rust; E.E.R. Philipp; T. Fritz; L. Henckaerts; R. Weersma; P. Stokkers; C.Y. Ponsioen; C. Wijmenga; M. Sterneck; M. Nothnagel; J. Hampe; A. Teufel; H. Runz; P. Rosenstiel; A. Stiehl; S. Vermeire; U. Beuers; M. Manns; E. Schrumpf; K.M. Boberg; S. Schreiber


    BACKGROUND & AIMS: We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single nucleotide polymorphism (SNP) markers. METHODS: A total of 443,816 SNPs on the Affymetrix SNP Array 5.0 (Affymetrix, Santa Clara, CA

  14. Assessment of core drug use indicators using WHO/INRUD methodology at primary healthcare centers in Bahawalpur, Pakistan.

    Atif, Muhammad; Sarwar, Muhammad Rehan; Azeem, Muhammad; Naz, Mubeen; Amir, Salma; Nazir, Kashaf


    Proper utilization of medicines is a critical component of pharmaceutical care plan. The aim of this study was to assess drug use pattern at ten primary healthcare centers (PHCCs) of the Bahawalpur district of the Punjab province of Pakistan by employing the WHO/INRUD core drug use indicators. This was a descriptive, non-experimental and cross-sectional study. For the prescribing indicators, 1000 prescriptions (100 prescriptions per PHCC) were systematically sampled out of the total 290,000 prescriptions written during January to December 2014. A total of 300 randomly selected patients (30 per PHCC) and 10 pharmacy personnel (one per PHCC) were observed and interviewed to investigate the patient-care and facility-specific indicators, respectively. We used published ideal standards for each of the WHO/INRUD indicators. Among the prescribing indicators, the average number of drugs per encounter was 3.4 (SD = 0.8) (optimal range = 1.6-1.8), the drugs prescribed by the generic name were 71.6% (optimal value = 100%), the encounters with an antibiotic prescribed were 48.9% (optimal range = 20.0-26.8%), the encounters with an injection prescribed were 27.1% (optimal range = 13.4-24.1%) and the drugs prescribed from the Essential Drugs List (EDL) were 93.4% (optimal value = 100%). Among the patient-care indicators, the average consultation time was 2.2 min (SD = 0.8) (optimal value ≥10 min), the average dispensing time was 38 s (SD = 12.1) (optimal value ≥90 s), the percentage of drugs actually dispensed was 90.9% (optimal value = 100%), the percentage of drugs adequately labeled was 100% (optimal value = 100%) and the patients' knowledge of correct dosage was 62.1% (optimal value = 100%). Among the facility-specific indicators, all PHCCs had a copy of the EDL and the key drugs available in the stock were 82% (optimal value = 100%). Irrational use of drugs was observed in all healthcare facilities. This study

  15. Comparative bacterial proteomics: analysis of the core genome concept.

    Stephen J Callister

    Full Text Available While comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry, experimental validation of the existence of this core genome requires extensive measurement and is typically not undertaken. Enabled by an extensive proteome database developed over six years, we have experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. Although genomic studies can establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits.

  16. Comparative Bacterial Proteomics: Analysis of the Core Genome Concept

    Callister, Stephen J.; McCue, Lee Ann; Turse, Josh E.; Monroe, Matthew E.; Auberry, Kenneth J.; Smith, Richard D.; Adkins, Joshua N.; Lipton, Mary S.


    Comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry. Experimental validation of the existence of this core genome requires extensive measurement and is not typically undertaken. Enabled by an extensive proteome database development over a six year period, we experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. While genomic studies establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits.

  17. Dendritic Structure Analysis of CMSX-4 Cored Turbine Blades Roots

    Krawczyk J.


    Full Text Available The microstructure of as-cast cored turbine blades roots, made of the single-crystal CMSX-4 nickel-based superalloy was investigated. Analysed blades were obtained by directional solidification technique in the industrial ALD Bridgman induction furnace. The investigations of the microstructure of blades roots were performed using SEM and X-ray techniques including diffraction topography with the use of Auleytner method. Characteristic shapes of dendrites with various arrangement were observed on the SEM images taken from the cross-sections, made transversely to the main blades axis. The differences in quality of the structure in particular areas of blades roots were revealed. Based on the results, the influence of cooling bores on blades root structure was analysed and the changes in the distribution and geometry of cooling bores were proposed.

  18. Comparative Bacterial Proteomics: Analysis of the Core Genome Concept

    Callister, Stephen J.; McCue, Lee Ann; Turse, Joshua E.; Monroe, Matthew E.; Auberry, Kenneth J.; Smith, Richard D.; Adkins, Joshua N.; Lipton, Mary S.


    While comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry, experimental validation of the existence of this core genome requires extensive measurement and is typically not undertaken. Enabled by an extensive proteome database developed over six years, we have experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. Although genomic studies can establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits. PMID:18253490

  19. Two dimensional dynamic analysis of sandwich plates with gradient foam cores

    Mu, Lin; Xiao, Deng Bao; Zhao, Guiping [State Key Laboratory for Mechanical structure Strength and Vibration, School of AerospaceXi' an Jiaotong University, Xi' an (China); Cho, Chong Du [Dept. of Mechanical Engineering, Inha University, Inchon (Korea, Republic of)


    Present investigation is concerned about dynamic response of composite sandwich plates with the functionally gradient foam cores under time-dependent impulse. The analysis is based on a model of the gradient sandwich plate, in which the face sheets and the core adopt the Kirchhoff theory and a [2, 1]-order theory, respectively. The material properties of the gradient foam core vary continuously along the thickness direction. The gradient plate model is validated with the finite element code ABAQUS®. And the results show that the proposed model can predict well the free vibration of composite sandwich plates with gradient foam cores. The influences of gradient foam cores on the natural frequency, deflection and energy absorbing of the sandwich plates are also investigated.

  20. Prognostic Importance of Gleason 7 Disease Among Patients Treated With External Beam Radiation Therapy for Prostate Cancer: Results of a Detailed Biopsy Core Analysis

    Spratt, Daniel E.; Zumsteg, Zach; Ghadjar, Pirus; Pangasa, Misha; Pei, Xin [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Fine, Samson W. [Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Yamada, Yoshiya; Kollmeier, Marisa [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Zelefsky, Michael J., E-mail: [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)


    Purpose: To analyze the effect of primary Gleason (pG) grade among a large cohort of Gleason 7 prostate cancer patients treated with external beam radiation therapy (EBRT). Methods and Materials: From May 1989 to January 2011, 1190 Gleason 7 patients with localized prostate cancer were treated with EBRT at a single institution. Of these patients, 613 had a Gleason 7 with a minimum of a sextant biopsy with nonfragmented cores and full biopsy core details available, including number of cores of cancer involved, percentage individual core involvement, location of disease, bilaterality, and presence of perineural invasion. Median follow-up was 6 years (range, 1-16 years). The prognostic implication for the following outcomes was analyzed: biochemical recurrence-free survival (bRFS), distant metastasis-free survival (DMFS), and prostate cancer-specific mortality (PCSM). Results: The 8-year bRFS rate for pG3 versus pG4 was 77.6% versus 61.3% (P<.0001), DMFS was 96.8% versus 84.3% (P<.0001), and PCSM was 3.7% versus 8.1% (P=.002). On multivariate analysis, pG4 predicted for significantly worse outcome in all parameters. Location of disease (apex, base, mid-gland), perineural involvement, maximum individual core involvement, and the number of Gleason 3+3, 3+4, or 4+3 cores did not predict for distant metastases. Conclusions: Primary Gleason grade 4 independently predicts for worse bRFS, DMFS, and PCSM among Gleason 7 patients. Using complete core information can allow clinicians to utilize pG grade as a prognostic factor, despite not having the full pathologic details from a prostatectomy specimen. Future staging and risk grouping should investigate the incorporation of primary Gleason grade when complete biopsy core information is used.

  1. Uncertainty analysis for the assembly and core simulation of BEAVRS at the HZP conditions

    Wan, Chenghui [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Cao, Liangzhi, E-mail: [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Wu, Hongchun [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Shen, Wei [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Canadian Nuclear Safety Commission, Ottawa, Ontario (Canada)


    Highlights: • Uncertainty analysis has been completed based on the “two-step” scheme. • Uncertainty analysis has been performed to BEAVRS at HZP. • For lattice calculations, the few-group constant’s uncertainty was quantified. • For core simulation, uncertainties of k{sub eff} and power distributions were quantified. - Abstract: Based on the “two-step” scheme for the reactor-physics calculations, the capability of uncertainty analysis for the core simulations has been implemented in the UNICORN code, an in-house code for the sensitivity and uncertainty analysis of the reactor-physics calculations. Applying the statistical sampling method, the nuclear-data uncertainties can be propagated to the important predictions of the core simulations. The uncertainties of the few-group constants introduced by the uncertainties of the multigroup microscopic cross sections are quantified first for the lattice calculations; the uncertainties of the few-group constants are then propagated to the core multiplication factor and core power distributions for the core simulations. Up to now, our in-house lattice code NECP-CACTI and the neutron-diffusion solver NECP-VIOLET have been implemented in UNICORN for the steady-state core simulations based on the “two-step” scheme. With NECP-CACTI and NECP-VIOLET, the modeling and simulation of the steady-state BEAVRS benchmark problem at the HZP conditions was performed, and the results were compared with those obtained by CASMO-4E. Based on the modeling and simulation, the UNICORN code has been applied to perform the uncertainty analysis for BAEVRS at HZP. The uncertainty results of the eigenvalues and two-group constants for the lattice calculations and the multiplication factor and the power distributions for the steady-state core simulations are obtained and analyzed in detail.

  2. Identifying and Tracking Individual Updraft Cores using Cluster Analysis: A TWP-ICE case study

    Li, X.; Tao, W.; Collis, S. M.; Varble, A.


    Cumulus parameterizations in GCMs depend strongly on the vertical velocity structures of convective updraft cores, or plumes. There hasn't been an accurate way of identifying these cores. The majority of previous studies treat the updraft as a single grid column entity, thus missing many intrinsic characteristics, e.g., the size, strength and spatial orientation of an individual core, its life cycle, and the time variations of the entrainment/detrainment rates associated with its life cycle. In this study, we attempt to apply an innovative algorithm based on the centroid-based k-means cluster analysis to improve our understanding of convection and its associated updraft cores. Both 3-D Doppler radar retrievals and cloud-resolving model simulations of a TWP-ICE campaign case during the monsoon period will be used to test and improve this algorithm. This will provide for more in-depth comparisons between CRM simulations and observations that were not possible previously using the traditional piecewise analysis with each updraft column. The first step is to identify the strongest cores (maximum velocity >10 m/s), since they are well defined and produce definite answers when the cluster analysis algorithm is applied. The preliminary results show that the radar retrieved updraft cores are smaller in size and with the maximum velocity located uniformly at higher levels compared with model simulations. Overall, the model simulations produce much stronger cores compared with the radar retrievals. Within the model simulations, the bulk microphysical scheme simulation produces stronger cores than the spectral bin microphysical scheme. Planned researches include using high temporal-resolution simulations to further track the life cycle of individual updraft cores and study their characteristics.

  3. African Primary Care Research: qualitative data analysis and writing results.

    Mabuza, Langalibalele H; Govender, Indiran; Ogunbanjo, Gboyega A; Mash, Bob


    This article is part of a series on African primary care research and gives practical guidance on qualitative data analysis and the presentation of qualitative findings. After an overview of qualitative methods and analytical approaches, the article focuses particularly on content analysis, using the framework method as an example. The steps of familiarisation, creating a thematic index, indexing, charting, interpretation and confirmation are described. Key concepts with regard to establishing the quality and trustworthiness of data analysis are described. Finally, an approach to the presentation of qualitative findings is given.

  4. Life cycle primary energy analysis of residential buildings

    Gustavsson, Leif; Joelsson, Anna [Ecotechnology, Department of Engineering and Sustainable Development, Mid Sweden University, SE-831 25 Oestersund (Sweden)


    The space heating demand of residential buildings can be decreased by improved insulation, reduced air leakage and by heat recovery from ventilation air. However, these measures result in an increased use of materials. As the energy for building operation decreases, the relative importance of the energy used in the production phase increases and influences optimization aimed at minimizing the life cycle energy use. The life cycle primary energy use of buildings also depends on the energy supply systems. In this work we analyse primary energy use and CO{sub 2} emission for the production and operation of conventional and low-energy residential buildings. Different types of energy supply systems are included in the analysis. We show that for a conventional and a low-energy building the primary energy use for production can be up to 45% and 60%, respectively, of the total, depending on the energy supply system, and with larger variations for conventional buildings. The primary energy used and the CO{sub 2} emission resulting from production are lower for wood-framed constructions than for concrete-framed constructions. The primary energy use and the CO{sub 2} emission depend strongly on the energy supply, for both conventional and low-energy buildings. For example, a single-family house from the 1970s heated with biomass-based district heating with cogeneration has 70% lower operational primary energy use than if heated with fuel-based electricity. The specific primary energy use with district heating was 40% lower than that of an electrically heated passive row house. (author)

  5. Results and analysis of saltstone cores taken from saltstone disposal unit cell 2A

    Reigel, M. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hill, K. A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    As part of an ongoing Performance Assessment (PA) Maintenance Plan, Savannah River Remediation (SRR) has developed a sampling and analyses strategy to facilitate the comparison of field-emplaced samples (i.e., saltstone placed and cured in a Saltstone Disposal Unit (SDU)) with samples prepared and cured in the laboratory. The primary objectives of the Sampling and Analyses Plan (SAP) are; (1) to demonstrate a correlation between the measured properties of laboratory-prepared, simulant samples (termed Sample Set 3), and the field-emplaced saltstone samples (termed Sample Set 9), and (2) to validate property values assumed for the Saltstone Disposal Facility (SDF) PA modeling. The analysis and property data for Sample Set 9 (i.e. six core samples extracted from SDU Cell 2A (SDU2A)) are documented in this report, and where applicable, the results are compared to the results for Sample Set 3. Relevant properties to demonstrate the aforementioned objectives include bulk density, porosity, saturated hydraulic conductivity (SHC), and radionuclide leaching behavior.

  6. Deconvolution-based resolution enhancement of chemical ice core records obtained by continuous flow analysis

    Rasmussen, Sune Olander; Andersen, Katrine K.; Johnsen, Sigfus Johann


    Continuous flow analysis (CFA) has become a popular measuring technique for obtaining high-resolution chemical ice core records due to an attractive combination of measuring speed and resolution. However, when analyzing the deeper sections of ice cores or cores from low-accumulation areas......, there is still need for further improvement of the resolution. Here a method for resolution enhancement of CFA data is presented. It is demonstrated that it is possible to improve the resolution of CFA data by restoring some of the detail that was lost in the measuring process, thus improving the usefulness...

  7. Using Profile Analysis via Multidimensional Scaling (PAMS) to identify core profiles from the WMS-III.

    Frisby, Craig L; Kim, Se-Kang


    Profile Analysis via Multidimensional Scaling (PAMS) is a procedure for extracting latent core profiles in a multitest data set. The PAMS procedure offers several advantages compared with other profile analysis procedures. Most notably, PAMS estimates individual profile weights that reflect the degree to which an individual's observed profile approximates the shape and scatter of latent core profiles. The PAMS procedure was applied to index scores of nonreplicated participants from the standardization sample (N = 1,033) for the Wechsler Memory Scale--Third Edition (D. Tulsky, J. Zhu, & M. F. Ledbetter, 2002). PAMS extracted discrepant visual memory and auditory memory versus working memory core profiles for the complete 16- to 89-year-old sample and discrepant working memory and auditory memory versus working memory core profiles for the 75- to 89-year-old cohort. Implications for use of PAMS in future research are discussed.

  8. Coherent Network Analysis of Gravitational Waves from Three-Dimensional Core-Collapse Supernova Models

    Hayama, Kazuhiro; Kotake, Kei; Takiwaki, Tomoya


    Using predictions from three-dimensional (3D) hydrodynamics simulations of core-collapse supernovae (CCSNe), we present a coherent network analysis to detection, reconstruction, and the source localization of the gravitational-wave (GW) signals. By combining with the GW spectrogram analysis, we show that several important hydrodynamics features imprinted in the original waveforms persist in the waveforms of the reconstructed signals. The characteristic excess in the GW spectrograms originates not only from rotating core-collapse and bounce, the subsequent ring down of the proto-neutron star (PNS) as previously identified, but also from the formation of magnetohydrodynamics jets and non-axisymmetric instabilities in the vicinity of the PNS. Regarding the GW signals emitted near at the rotating core bounce, the horizon distance, which we set by a SNR exceeding 8, extends up to $\\sim$ 18 kpc for the most rapidly rotating 3D model among the employed waveform libraries. Following the rotating core bounce, the domi...

  9. ASTEC adaptation for PHWR limited core damage accident analysis

    Majumdar, P., E-mail: [Bhabha Atomic Research Centre, Reactor Safety Division, Mumbai 400085 (India); Chatterjee, B.; Lele, H.G. [Bhabha Atomic Research Centre, Reactor Safety Division, Mumbai 400085 (India); Guillard, G.; Fichot, F. [Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSN-RES/SAG, Cadarache, 13115 Saint-Paul-lez-Durance (France)


    Under limited core damage accidents (LCDAs) of Pressurized Heavy Water Reactor (PHWR), coolable geometry of the channel might be retained thanks to the presence of moderator heat sink. Indeed, the pressure tube is amenable to creep deformation at high temperature due to internal pressure and fuel bundles weight. Partial or complete circumferential contact between pressure tube and calandria tube aids heat dissipation to the moderator. A new module has been developed by Bhabha Atomic Research Centre (BARC) for simulating this phenomenon which is specific to horizontal-type of reactors. It requires additional calculation of pressure tube sagging/ballooning and temperature field in the circumferential direction. The module is well validated with available experimental results concerning pressure tube deformation and the associated heat transfer in the area of contact. It is then used in analysing typical LCDAs scenarios in Indian PHWR under low and medium internal pressure conditions. This module is implemented in the ASTEC IRSN-GRS severe accident code version under development and will thus be available in the next major version V2.1.

  10. Thermal buckling analysis of truss-core sandwich plates

    陈继伟; 刘咏泉; 刘伟; 苏先樾


    Truss-core sandwich plates have received much attention in virtue of the high values of strength-to-weight and stiffness-to-weight as well as the great ability of impulse-resistance recently. It is necessary to study the stability of sandwich panels under the influence of the thermal load. However, the sandwich plates are such complex three-dimensional (3D) systems that direct analytical solutions do not exist, and the finite element method (FEM) cannot represent the relationship between structural parameters and mechanical properties well. In this paper, an equivalent homogeneous continuous plate is idealized by obtaining the effective bending and transverse shear stiffness based on the characteristics of periodically distributed unit cells. The first order shear deformation theory for plates is used to derive the stability equation. The buckling temperature of a simply supported sandwich plate is given and verified by the FEM. The effect of related parameters on mechanical properties is investigated. The geometric parameters of the unit cell are optimized to attain the maximum buckling temperature. It is shown that the optimized sandwich plate can improve the resistance to thermal buckling significantly.

  11. Steady state thermal hydraulic analysis of LMR core using COBRA-K code

    Kim, Eui Kwang; Kim, Young Gyun; Kim Young In; Kim Young Cheol


    A thermal hydraulics analysis code COBRA-K is being developed by the KAERI LMR core design technology development team. COBRA-K is a part of the integrated computation system for LMR core design and analysis, the K-CORE system. COBRA-K is supposed to predict the flow and temperature distributions in LMR core. COBRA-K is an extension of the previously published COBRA-IV-I code with several functional improvements. Specially COBRA-K has been improved to analyze single and multi-assembly, and whole-core in the transient condition. This report describes the overall features of COBRA-K and gives general input descriptions. The 19 pin assembly experimental data of ORNL were used to verify the accuracy of this code for the steady state analysis. The comparative results show good agreements between the calculated and the measured data. And COBRA-K can be used to predict flow and temperature distributions for the LMR core design. (author). 7 refs., 6 tabs., 13 figs.

  12. Analysis of core samples from the BPXA-DOE-USGS Mount Elbert gas hydrate stratigraphic test well: Insights into core disturbance and handling

    Kneafsey, Timothy J.; Lu, Hailong; Winters, William; Boswell, Ray; Hunter, Robert; Collett, Timothy S.


    Collecting and preserving undamaged core samples containing gas hydrates from depth is difficult because of the pressure and temperature changes encountered upon retrieval. Hydrate-bearing core samples were collected at the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well in February 2007. Coring was performed while using a custom oil-based drilling mud, and the cores were retrieved by a wireline. The samples were characterized and subsampled at the surface under ambient winter arctic conditions. Samples thought to be hydrate bearing were preserved either by immersion in liquid nitrogen (LN), or by storage under methane pressure at ambient arctic conditions, and later depressurized and immersed in LN. Eleven core samples from hydrate-bearing zones were scanned using x-ray computed tomography to examine core structure and homogeneity. Features observed include radial fractures, spalling-type fractures, and reduced density near the periphery. These features were induced during sample collection, handling, and preservation. Isotopic analysis of the methane from hydrate in an initially LN-preserved core and a pressure-preserved core indicate that secondary hydrate formation occurred throughout the pressurized core, whereas none occurred in the LN-preserved core, however no hydrate was found near the periphery of the LN-preserved core. To replicate some aspects of the preservation methods, natural and laboratory-made saturated porous media samples were frozen in a variety of ways, with radial fractures observed in some LN-frozen sands, and needle-like ice crystals forming in slowly frozen clay-rich sediments. Suggestions for hydrate-bearing core preservation are presented.

  13. A High-Resolution Continuous Flow Analysis System for Polar Ice Cores

    Dallmayr, Remi; Goto-Azuma, Kumiko; Kjær, Helle Astrid;


    of Polar Research (NIPR) in Tokyo. The system allows the continuous analysis of stable water isotopes and electrical conductivity, as well as the collection of discrete samples from both inner and outer parts of the core. This CFA system was designed to have sufficiently high temporal resolution to detect......In recent decades, the development of continuous flow analysis (CFA) technology for ice core analysis has enabled greater sample throughput and greater depth resolution compared with the classic discrete sampling technique. We developed the first Japanese CFA system at the National Institute...

  14. African Primary Care Research: quantitative analysis and presentation of results.

    Mash, Bob; Ogunbanjo, Gboyega A


    This article is part of a series on Primary Care Research Methods. The article describes types of continuous and categorical data, how to capture data in a spreadsheet, how to use descriptive and inferential statistics and, finally, gives advice on how to present the results in text, figures and tables. The article intends to help Master's level students with writing the data analysis section of their research proposal and presenting their results in their final research report.

  15. African Primary Care Research: Quantitative analysis and presentation of results

    Bob Mash


    Full Text Available This article is part of a series on Primary Care Research Methods. The article describes types of continuous and categorical data, how to capture data in a spreadsheet, how to use descriptive and inferential statistics and, finally, gives advice on how to present the results in text, figures and tables. The article intends to help Master’s level students with writing the data analysis section of their research proposal and presenting their results in their final research report.

  16. Transient and stability analysis of a BWR core with thorium-uranium fuel

    Nunez-Carrera, Alejandro [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan 779 Col. Narvarte, 03020 Mexico, DF (Mexico); Espinosa-Paredes, Gilberto [Division de Ciencias Basicas e Ingenieria, Universidad Autonoma Metropolitana, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Mexico, DF (Mexico)], E-mail:; Francois, Juan-Luis [Departamento de Sistemas Energeticos, Facultad de Ingenieria, Universidad Nacional Autonoma de Mexico, Paseo Cuauhnahuac 8532, 62550 Jiutepec Mor. (Mexico)


    The kinetic response of a boiling water reactor (BWR) equilibrium core using thorium as a nuclear material, in an integrated blanket-seed assembly, is presented in this work. Additionally an in-house code was developed to evaluate this core under steady state and transient conditions including a stability analysis. The code has two modules: (a) the time domain module for transient analysis and (b) the frequency domain module for stability analysis. The thermal-hydraulic process is modeled by a set of five equations, considering no homogeneous flow with drift-flux approximation and non-equilibrium thermodynamic. The neutronic process is calculated with a point kinetics model. Typical BWR reactivity effects are considered: void fraction, fuel temperature, moderator temperature and control rod density. Collapsed parameters were included in the code to represent the core using an average fuel channel. For the stability analysis, in the frequency domain, the transfer function is determined by applying Laplace-transforming to the calculated pressure drop perturbations in each of the considered regions where a constant total pressure drop was considered. The transfer function was used to study the system response in the frequency domain when an inlet flow perturbation is applied. The results show that the neutronic behavior of the core with thorium uranium fuel is similar to a UO{sub 2} core, even during transient conditions. The stability and transient analysis show that the thorium-uranium fuel can be operated safely in current BWRs.

  17. Analysis of Monolith Cores from an Engineering Scale Demonstration of a Prospective Cast Stone Process

    Crawford, C. L. [Savannah River Site (SRS), Aiken, SC (United States); Cozzi, A. D. [Savannah River Site (SRS), Aiken, SC (United States); Hill, K. A. [Savannah River Site (SRS), Aiken, SC (United States)


    The primary disposition path of Low Activity Waste (LAW) at the DOE Hanford Site is vitrification. A cementitious waste form is one of the alternatives being considered for the supplemental immobilization of the LAW that will not be treated by the primary vitrification facility. Washington River Protection Solutions (WRPS) has been directed to generate and collect data on cementitious or pozzolanic waste forms such as Cast Stone. This report documents the coring and leach testing of monolithic samples cored from an engineering-scale demonstration (ES Demo) with non-radioactive simulants. The ES Demo was performed at SRNL in October of 2013 using the Scaled Continuous Processing Facility (SCPF) to fill an 8.5 ft. diameter x 3.25 ft. high container with simulated Cast Stone grout. The Cast Stone formulation was chosen from the previous screening tests. Legacy salt solution from previous Hanford salt waste testing was adjusted to correspond to the average LAW composition generated from the Hanford Tank Waste Operation Simulator (HTWOS). The dry blend materials, ordinary portland cement (OPC), Class F fly ash, and ground granulated blast furnace slag (GGBFS or BFS), were obtained from Lafarge North America in Pasco, WA. In 2014 core samples originally obtained approximately six months after filling the ES Demo were tested along with bench scale molded samples that were collected during the original pour. A latter set of core samples were obtained in late March of 2015, eighteen months after completion of the original ES Demo. Core samples were obtained using a 2” diameter x 11” long coring bit. The ES Demo was sampled in three different regions consisting of an outer ring, a middle ring and an inner core zone. Cores from these three lateral zones were further segregated into upper, middle and lower vertical segments. Monolithic core samples were tested using the Environmental Protection Agency (EPA) Method 1315, which is designed to provide mass transfer rates

  18. Primary component analysis method and reduction of seismicity parameters

    WANG Wei; MA Qin-zhong; LIN Ming-zhou; WU Geng-feng; WU Shao-chun


    In the paper, the primary component analysis is made using 8 seismicity parameters of earthquake frequency N (ML≥3.0), b-value, 7-value, A(b)-value, Mf-value, Ac-value, C-value and D-value that reflect the characteristics of magnitude, time and space distribution of seismicity from different respects. By using the primary component analysis method, the synthesis parameter W reflecting the anomalous features of earthquake magnitude, time and space distribution can be gained. Generally, there is some relativity among the 8 parameters, but their variations are different in different periods. The earthquake prediction based on these parameters is not very well. However,the synthesis parameter W showed obvious anomalies before 13 earthquakes (MS>5.8) occurred in North China,which indicates that the synthesis parameter W can reflect the anomalous characteristics of magnitude, time and space distribution of seismicity better. Other problems related to the conclusions drawn by the primary component analysis method are also discussed.

  19. Using Profile Analysis via Multidimensional Scaling (PAMS) to Identify Core Profiles from the WMS-III

    Frisby, Craig L.; Kim, Se-Kang


    Profile Analysis via Multidimensional Scaling (PAMS) is a procedure for extracting latent core profiles in a multitest data set. The PAMS procedure offers several advantages compared with other profile analysis procedures. Most notably, PAMS estimates individual profile weights that reflect the degree to which an individual's observed profile…

  20. A Methodology for Loading the Advanced Test Reactor Driver Core for Experiment Analysis

    Cowherd, Wilson M.; Nielsen, Joseph W.; Choe, Dong O.


    In support of experiments in the ATR, a new methodology was devised for loading the ATR Driver Core. This methodology will replace the existing methodology used by the INL Neutronic Analysis group to analyze experiments. Studied in this paper was the as-run analysis for ATR Cycle 152B, specifically comparing measured lobe powers and eigenvalue calculations.

  1. David Coleman and the Technologisation of the Common Core: A Critical Discourse Analysis

    Johnson, Lindy L.


    Drawing on sociocultural perspectives and New Literacies Studies this study uses Critical Discourse Analysis (CDA) as a tool to closely analyse one way the Common Core State Standards in the United States are being produced, disseminated and consumed. The analysis focuses on a section of the CCSS, a model lesson given by one of the primary…

  2. Exploring ice core drilling chips from a cold Alpine glacier for cosmogenic radionuclide (10Be) analysis

    Zipf, Lars; Merchel, Silke; Bohleber, Pascal; Rugel, Georg; Scharf, Andreas

    Ice cores offer unique multi-proxy paleoclimate records, but provide only very limited sample material, which has to be carefully distributed for various proxy analyses. Beryllium-10, for example, is analysed in polar ice cores to investigate past changes of the geomagnetic field, solar activity, and the aerosol cycle, as well as to more accurately date the material. This paper explores the suitability of a drilling by-product, the so-called drilling chips, for 10Be-analysis. An ice core recently drilled at a cold Alpine glacier is used to directly compare 10Be-data from ice core samples with corresponding drilling chips. Both sample types have been spiked with 9Be-carrier and identically treated to chemically isolate beryllium. The resulting BeO has been investigated by accelerator mass spectrometry (AMS) for 10Be/9Be-ratios to calculate 10Be-concentrations in the ice. As a promising first result, four out of five sample-combinations (ice core and drilling chips) agree within 2-sigma uncertainty range. However, further studies are needed in order to fully demonstrate the potential of drilling chips for 10Be-analysis in alpine and shallow polar ice cores.

  3. Prompt Gamma Activation Analysis of the Nyírlugos obsidian core depot find

    Zsolt Kasztovszky


    Full Text Available The Nyírlugos obsidian core depot find is one of the most important lithic assemblages in the collection of the Hungarian National Museum (HNM. The original set comprised 12 giant obsidian cores, of which 11 are currently on the permanent archaeological exhibition of the HNM. One of the cores is known to be inDebrecen. The first publication attributed the hoard, on the strength of giant (flint blades known from the Early and Middle Copper Age Tiszapolgár and Bodrogkeresztúr cultures, to the Copper Age. In the light of recent finds it is more likely to belong to the Middle Neolithic period. The source area was defined as Tokaj Mts., about100 kmto the NW from Nyírlugos. The size and beauty of the exceptional pieces exclude any invasive analysis. Using Prompt Gamma Activation Analysis (PGAA, we can measure major chemical components and some key trace elements of stone artefacts with adequate accuracy to successfully determine provenance of obsidian. Recent methodological development also facilitated the study of relatively large objects like the Nyírlugos cores. The cores were individually measured by PGAA. The results show that the cores originate from the Carpathian 1 sources, most probably the Viničky variety (C1b. The study of the hoard as a batch is an important contribution to the assessment of prehistoric trade and allows us to reconsider the so-called Carpathian, especially Carpathian 1 (Slovakian sources.

  4. Crack stability analysis of low alloy steel primary coolant pipe

    Tanaka, T.; Kameyama, M. [Kansai Electric Power Company, Osaka (Japan); Urabe, Y. [Mitsubishi Heavy Industries, Ltd., Takasago (Japan)] [and others


    At present, cast duplex stainless steel has been used for the primary coolant piping of PWRs in Japan and joints of dissimilar material have been applied for welding to reactor vessels and steam generators. For the primary coolant piping of the next APWR plants, application of low alloy steel that results in designing main loops with the same material is being studied. It means that there is no need to weld low alloy steel with stainless steel and that makes it possible to reduce the welding length. Attenuation of Ultra Sonic Wave Intensity is lower for low alloy steel than for stainless steel and they have advantageous inspection characteristics. In addition to that, the thermal expansion rate is smaller for low alloy steel than for stainless steel. In consideration of the above features of low alloy steel, the overall reliability of primary coolant piping is expected to be improved. Therefore, for the evaluation of crack stability of low alloy steel piping to be applied for primary loops, elastic-plastic future mechanics analysis was performed by means of a three-dimensioned FEM. The evaluation results for the low alloy steel pipings show that cracks will not grow into unstable fractures under maximum design load conditions, even when such a circumferential crack is assumed to be 6 times the size of the wall thickness.

  5. Analysis of ferroresonance in a neutral grounding system with nonlinear core loss

    Hui Meng; Zhang Yan-Bin; Liu Chong-Xin


    The chaotic behaviour exhibited by a typical ferroresonant circuit in a neutral grounding system is investigated in this paper. In most earlier ferroresonance studies the core loss of the power transformer was neglected or represented by a linear resistance. However, this is not always true. In this paper the core loss of the power transformer is modelled by a third order series in voltage and the magnetization characteristics of the transformer are modelled by an 11th order two-term polynomial. Extensive simulations are carried out to analyse the effect of nonlinear core loss on transformer ferroresonance. A detailed analysis of simulation results demonstrates that, with the nonlinear core loss model used, the onset of chaos appears at a larger source voltage and the transient duration is shorter.

  6. Gap analysis: a method to assess core competency development in the curriculum.

    Fater, Kerry H


    To determine the extent to which safety and quality improvement core competency development occurs in an undergraduate nursing program. Rapid change and increased complexity of health care environments demands that health care professionals are adequately prepared to provide high quality, safe care. A gap analysis compared the present state of competency development to a desirable (ideal) state. The core competencies, Nurse of the Future Nursing Core Competencies, reflect the ideal state and represent minimal expectations for entry into practice from pre-licensure programs. Findings from the gap analysis suggest significant strengths in numerous competency domains, deficiencies in two competency domains, and areas of redundancy in the curriculum. Gap analysis provides valuable data to direct curriculum revision. Opportunities for competency development were identified, and strategies were created jointly with the practice partner, thereby enhancing relevant knowledge, attitudes, and skills nurses need for clinical practice currently and in the future.

  7. An analysis of the meaning of integrated Primary Health Care from the KwaZulu- Natal Primary Health Care context

    M.N. Sibiya


    Full Text Available In South Africa, integration o f services policy was enacted in 1996 with the aim of increasing health service utilization by increasing accessibility and availability of all health care services at Primary Health Care (PHC level. Integration of PHC services continues to be seen as a pivotal strategy towards the achievement of the national goals of transformation of health services, and the attainment of a comprehensive and seamless public health system. Although the drive behind the integration of PHC services was to improve accessibility of services to the community, the problem however, arises in the implementation of integrated PHC (IPHC as there is no agreed upon understanding of what this phenomenon means in the South African context. To date no research studies have been reported on the meaning of the integration of PHC services. Hence, there is a need for shared views on this phenomenon in order to facilitate an effective implementation of this approach. A cross-sectional study, using a qualitative approach was employed in this study in order to analyze the phenomenon, IPHC in KwaZulu-Natal and the meaning attached to it in different levels of the health system. A grounded theory was selected as it is a method known for its ability to make greatest contribution in areas where little research has been done and when new viewpoints are needed to describe the familiar phenomenon that is not clearly understood. Policy makers and co-ordinators of PHC at national, provincial and district levels as well as PHC nurses at functional level participated in the study. The data was collected by means of observations, interviews and document analysis. The sample size for interviews was comprised of 38 participants. Strauss and Corbin’s process of data analysis was used. It emerged that there were three core categories that were used by the participants as discriminatory dimensions of IPHC in South Africa. These core categories were (a comprehensive

  8. Full core analysis of IRIS reactor by using MCNPX.

    Amin, E A; Bashter, I I; Hassan, Nabil M; Mustafa, S S


    This paper describes neutronic analysis for fresh fuelled IRIS (International Reactor Innovative and Secure) reactor by MCNPX code. The analysis included criticality calculations, radial power and axial power distribution, nuclear peaking factor and axial offset percent at the beginning of fuel cycle. The effective multiplication factor obtained by MCNPX code is compared with previous calculations by HELIOS/NESTLE, CASMO/SIMULATE, modified CORD-2 nodal calculations and SAS2H/KENO-V code systems. It is found that k-eff value obtained by MCNPX is closer to CORD-2 value. The radial and axial powers are compared with other published results carried out using SAS2H/KENO-V code. Moreover, the WIMS-D5 code is used for studying the effect of enriched boron in form of ZrB2 on the effective multiplication factor (K-eff) of the fuel pin. In this part of calculation, K-eff is calculated at different concentrations of Boron-10 in mg/cm at different stages of burnup of unit cell. The results of this part are compared with published results performed by HELIOS code.

  9. Safety analysis for operating the Annular Core Research Reactor with Cintichem-type targets installed in the central region of the core



    Production of the molybdenum-99 isotope at the Annular Core Research Reactor requires highly enriched, uranium oxide loaded targets to be irradiated for several days in the high neutron-flux region of the core. This report presents the safety analysis for the irradiation of up to seven Cintichem-type targets in the central region of the core and compares the results to the Annular Core Research Reactor Safety Analysis Report. A 19 target grid configuration is presented that allows one to seven targets to be irradiated, with the remainder of the grid locations filled with aluminum ''void'' targets. Analyses of reactor, neutronic, thermal hydraulics, and heat transfer calculations are presented. Steady-state operation and accident scenarios are analyzed with the conclusion that the reactor can be operated safely with seven targets in the grid, and no additional risk to the public.

  10. Determination of power distribution in the VVER-440 core on the basis of data from in-core monitors by means of a metric analysis

    Kryanev, A. V.; Udumyan, D. K.; Kurchenkov, A. Yu.; Gagarinskiy, A. A.


    Problems associated with determining the power distribution in the VVER-440 core on the basis of a neutron-physics calculation and data from in-core monitors are considered. A new mathematical scheme is proposed for this on the basis of a metric analysis. In relation to the existing mathematical schemes, the scheme in question improves the accuracy and reliability of the resulting power distribution.

  11. Analysis of pan-genome to identify the core genes and essential genes of Brucella spp.

    Yang, Xiaowen; Li, Yajie; Zang, Juan; Li, Yexia; Bie, Pengfei; Lu, Yanli; Wu, Qingmin


    Brucella spp. are facultative intracellular pathogens, that cause a contagious zoonotic disease, that can result in such outcomes as abortion or sterility in susceptible animal hosts and grave, debilitating illness in humans. For deciphering the survival mechanism of Brucella spp. in vivo, 42 Brucella complete genomes from NCBI were analyzed for the pan-genome and core genome by identification of their composition and function of Brucella genomes. The results showed that the total 132,143 protein-coding genes in these genomes were divided into 5369 clusters. Among these, 1710 clusters were associated with the core genome, 1182 clusters with strain-specific genes and 2477 clusters with dispensable genomes. COG analysis indicated that 44 % of the core genes were devoted to metabolism, which were mainly responsible for energy production and conversion (COG category C), and amino acid transport and metabolism (COG category E). Meanwhile, approximately 35 % of the core genes were in positive selection. In addition, 1252 potential essential genes were predicted in the core genome by comparison with a prokaryote database of essential genes. The results suggested that the core genes in Brucella genomes are relatively conservation, and the energy and amino acid metabolism play a more important role in the process of growth and reproduction in Brucella spp. This study might help us to better understand the mechanisms of Brucella persistent infection and provide some clues for further exploring the gene modules of the intracellular survival in Brucella spp.

  12. Free vibration analysis of simply supported sandwich beams with lattice truss core

    Lou, Jia, E-mail: [Center for Composite Materials and Structures, Harbin Institute of Technology, P.O. Box 3011, Science Park of HIT, No. 2 Yi-Kuang Street, Harbin 150080 (China); Ma, Li, E-mail: [Center for Composite Materials and Structures, Harbin Institute of Technology, P.O. Box 3011, Science Park of HIT, No. 2 Yi-Kuang Street, Harbin 150080 (China); Wu, Lin-Zhi, E-mail: [Center for Composite Materials and Structures, Harbin Institute of Technology, P.O. Box 3011, Science Park of HIT, No. 2 Yi-Kuang Street, Harbin 150080 (China)


    Free vibration of AISI 304 stainless steel sandwich beams with pyramidal truss core is investigated in the present paper. The lattice truss core is transformed to a continuous homogeneous material. Considering the deformation characteristics of the sandwich beam, the following assumptions are made: (1) the thickness of the sandwich beam remains constant during deformation; (2) for the thin face sheets, only bending deformation is considered, neglecting the effect of transverse shear deformation; (3) for the core, only shear deformation is considered as the core is too weak to provide a significant contribution to the bending stiffness of the sandwich beam. The shear stress is assumed to be constant along the thickness of the core. The governing equation of free vibration is derived from Hamilton's principle, and the natural frequencies are calculated under simply supported boundary conditions. Finally, numerical simulation is carried out to get the mode shapes and natural frequencies. Our results show that the theoretical solutions agree well with the numerical results. It indicates the present method would be useful for free vibration analysis of sandwich beams with lattice truss core.

  13. Analysis of Stainless Steel Sandwich Panels with a Metal Foam Core for Lightweight Fan Blade Design

    Min, James B.; Ghosn, Louis J.; Lerch, Bradley A.; Raj, Sai V.; Holland, Frederic A., Jr.; Hebsur, Mohan G.


    The quest for cheap, low density and high performance materials in the design of aircraft and rotorcraft engine fan and propeller blades poses immense challenges to the materials and structural design engineers. The present study investigates the use of a sandwich foam fan blade mae up of solid face sheets and a metal foam core. The face sheets and the metal foam core material were an aerospace grade precipitation hardened 17-4 PH stainless steel with high strength and high toughness. The resulting structures possesses a high stiffness while being lighter than a similar solid construction. The material properties of 17-4 PH metal foam are reviewed briefly to describe the characteristics of sandwich structure for a fan blade application. A vibration analysis for natural frequencies and a detailed stress analysis on the 17-4 PH sandwich foam blade design for different combinations of kin thickness and core volume are presented with a comparison to a solid titanium blade.

  14. A method for analysis of vanillic acid in polar ice cores

    M. M. Grieman


    Full Text Available Biomass burning generates a wide range of organic compounds that are transported via aerosols to the polar ice sheets. Vanillic acid is a product of conifer lignin combustion, which has previously been observed in laboratory and ambient biomass burning aerosols. In this study a method was developed for analysis of vanillic acid in melted polar ice core samples. Vanillic acid was chromatographically separated using reversed phase LC and detected using electrospray triple quadrupole mass spectrometry (ESI-MS/MS. Using a 100 μL injection loop and analysis time of 4 min, we obtained a detection limit (S : N = 2 of 58 ppt (parts per trillion by mass and an analytical precision of ±10 %. Measurements of vanillic acid in Arctic ice core samples from the Siberian Akademii Nauk core are shown as an example application of the method.

  15. Development of Uncertainty Analysis Method for SMART Digital Core Protection and Monitoring System

    Koo, Bon Seung; In, Wang Kee; Hwang, Dae Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The Korea Atomic Energy Research Institute has developed a system-integrated modular advanced reactor (SMART) for a seawater desalination and electricity generation. Online digital core protection and monitoring systems, called SCOPS and SCOMS respectively were developed. SCOPS calculates minimum DNBR and maximum LPD based on the several online measured system parameters. SCOMS calculates the variables of limiting conditions for operation. KAERI developed overall uncertainty analysis methodology which is used statistically combining uncertainty components of SMART core protection and monitoring system. By applying overall uncertainty factors in on-line SCOPS/SCOMS calculation, calculated LPD and DNBR are conservative with a 95/95 probability/confidence level. In this paper, uncertainty analysis method is described for SMART core protection and monitoring system

  16. Compression After Impact on Honeycomb Core Sandwich Panels with Thin Facesheets, Part 2: Analysis

    Mcquigg, Thomas D.; Kapania, Rakesh K.; Scotti, Stephen J.; Walker, Sandra P.


    A two part research study has been completed on the topic of compression after impact (CAI) of thin facesheet honeycomb core sandwich panels. The research has focused on both experiments and analysis in an effort to establish and validate a new understanding of the damage tolerance of these materials. Part 2, the subject of the current paper, is focused on the analysis, which corresponds to the CAI testings described in Part 1. Of interest, are sandwich panels, with aerospace applications, which consist of very thin, woven S2-fiberglass (with MTM45-1 epoxy) facesheets adhered to a Nomex honeycomb core. Two sets of materials, which were identical with the exception of the density of the honeycomb core, were tested in Part 1. The results highlighted the need for analysis methods which taken into account multiple failure modes. A finite element model (FEM) is developed here, in Part 2. A commercial implementation of the Multicontinuum Failure Theory (MCT) for progressive failure analysis (PFA) in composite laminates, Helius:MCT, is included in this model. The inclusion of PFA in the present model provided a new, unique ability to account for multiple failure modes. In addition, significant impact damage detail is included in the model. A sensitivity study, used to assess the effect of each damage parameter on overall analysis results, is included in an appendix. Analysis results are compared to the experimental results for each of the 32 CAI sandwich panel specimens tested to failure. The failure of each specimen is predicted using the high-fidelity, physicsbased analysis model developed here, and the results highlight key improvements in the understanding of honeycomb core sandwich panel CAI failure. Finally, a parametric study highlights the strength benefits compared to mass penalty for various core densities.

  17. [Primary failure of eruption (PFE). Clinical and molecular genetics analysis].

    Stellzig-Eisenhauer, Angelika; Decker, Eva; Meyer-Marcotty, Philipp; Rau, Christiane; Fiebig, Britta S; Kress, Wolfram; Saar, Kathrin; Rüschendorf, Franz; Hubner, Norbert; Grimm, Tiemo; Witt, Emil; Weber, Bernhard H F


    The term "primary failure of eruption" (PFE) refers to the complete or partial failure of a primary non-ankylosed tooth to erupt due to a disturbance of the eruption mechanism. Up to now, the molecular basis for this failure was unknown. Four families were studied in whom at least two members were affected by non-syndromic PFE as part of a clinical and molecular genetics study. Radiological diagnostics (OPTs) were carried out in all patients and their unaffected relatives (control group). The genetic analysis included a genomewide linkage analysis followed by direct DNA sequencing of positional candidate genes. Starting from the index patients, we were able to reconstruct pedigrees over two and/or three generations in the families that indicated an autosomal-dominant mode of inheritance of non-syndromic PFE. Fifteen patients were diagnosed with PFE. Gender distribution was nearly equal (7 female, 8 male). Molecular genetic analysis of the PTHR1 gene revealed three distinct heterozygous mutations (c.1050-3C>G; c.543 + 1G>A; c.463G>T). Unaffected persons exhibited no mutations. Knowledge of the genetic causes of non-syndromic PFE can now be used for the differential diagnosis of eruption failure. It permits affected family members to be identified early and may lead to new treatment possibilities in the long term. The genetically-verified diagnosis of "primary failure of eruption" can protect patients and orthodontists from years of futile treatment, because orthodontic treatment alone does not lead to success. Moreover, it has a negative influence on unaffected teeth and areas of the jaw. © EDP Sciences, SFODF, 2013.

  18. Computational Design and Analysis of Core Material of Single-Phase Capacitor Run Induction Motor

    Gurmeet Singh


    Full Text Available A Single-phase induction motor (SPIM has very crucial role in industrial, domestic and commercial sectors. So, the efficient SPIM is a foremost requirement of today's market. For efficient motors, many research methodologies and propositions have been given by researchers in past. Various parameters like as stator/rotor slot variation, size and shape of stator/rotor slots, stator/rotor winding configuration, choice of core material etc. have momentous impact on machine design. Core material influences the motor performance to a degree. Magnetic flux linkage and leakage preliminary depends upon the magnetic properties of core material and air gap. The analysis of effects of core material on the magnetic flux distribution and the performance of induction motor is of immense importance to meet out the desirable performance. An increase in the air gap length will result in the air gap performance characteristics deterioration and decrease in air gap length will lead to serious mechanical balancing concern. So possibility of much variation in air gap beyond the limits on both sides is not feasible. For the optimized performance of the induction motor the core material plays a significant role. Using higher magnetic flux density, reduction on a magnetizing reactance and leakage of flux can be achieved. In this thesis work the analysis of single phase induction motor has been carried out with different core materials. The four models have been simulated using Ansys Maxwell 15.0. Higher flux density selection for same machine dimensions result into huge amount of reduction in iron core losses and thereby improve the efficiency. In this paper 2% higher efficiency has been achieved with Steel_1010 as compared to the machine using conventional D23 material. Out of four models result reflected by the machine using steel_1010 and steel_1008 are found to be better.

  19. A study on the core analysis methodology for SMART CEA ejection accident-I

    Zee, Sung Kyun; Lee, Chung Chan; Kim, Kyo Yoon; Cho, Byung Oh


    A methodology to analyze the fuel enthalpy is developed based on MASTER that is a time dependent 3 dimensional core analysis code. Using the proposed methodology, SMART CEA ejection accident is analyzed. Moreover, radiation doses are estimated at the exclusion area boundary and low population zone to confirm the criteria for the accident. (Author). 31 refs., 13 tabs., 18 figs.

  20. Direct chemical analysis of frozen ice cores by UV-laser ablation ICPMS

    Müller, Wolfgang; Shelley, J. Michael G.; Rasmussen, Sune Olander


    Cryo-cell UV-LA-ICPMS is a new technique for direct chemical analysis of frozen ice cores at high spatial resolution (micrometer). It was tested in a pilot study on NGRIP ice and reveals sea ice/dust records and annual layer signatures at unprecedented spatial/time resolution. Uniquely...

  1. Coupled analysis of core thermal hydraulics and fuel performance to evaluate a thermally induced fuel failure in an SFR subassembly

    Choi, Sun Rock; Chang, Doo Soo; Kim, Sang Ji [KAERI, Daejeon (Korea, Republic of)


    A limiting factor analysis in a core thermal design is highly important to assure the safe and reliable operation of a reactor system. In a sodium cooled fast reactor (SFR), the coolant thermal conductivity is about hundreds of times larger than the thermal conductivity of water. Moreover, the coolant boiling temperature in an SFR is around 900 .deg. C, which is much higher than that of the water coolant in a PWR. Considering typical operating temperatures, an SFR has about a 300 .deg. C thermal margin to its boiling point. Therefore, instead of DNBR (Departure from Nucleate Boiling Ratio) in a PWR, the core thermal design of SFRs requires assuring proper fuel performance and safety, where the design limits are highly related to the temperature distribution and material behavior under various operating conditions. Typical limiting factors in SFRs are the thermal component of the plastic hoop strain, radial primary hoop stress, and cumulative damage factor during normal operation. However, the previous fuel performance codes only evaluate a single fuel pin performance, which neglects the radial peaking factors and reveals too conservative results. In this work, the multi physics analysis is performed using both thermalhydraulic and fuel performance codes.

  2. Optimization of High-Resolution Continuous Flow Analysis for Transient Climate Signals in Ice Cores

    Bigler, Matthias; Svensson, Anders; Kettner, Ernesto


    Over the past two decades, continuous flow analysis (CFA) systems have been refined and widely used to measure aerosol constituents in polar and alpine ice cores in very high-depth resolution. Here we present a newly designed system consisting of sodium, ammonium, dust particles, and electrolytic...... meltwater conductivity detection modules. The system is optimized for high- resolution determination of transient signals in thin layers of deep polar ice cores. Based on standard measurements and by comparing sections of early Holocene and glacial ice from Greenland, we find that the new system features...

  3. A High-Resolution Continuous Flow Analysis System for Polar Ice Cores

    Dallmayr, Remi; Goto-Azuma, Kumiko; Kjær, Helle Astrid


    of Polar Research (NIPR) in Tokyo. The system allows the continuous analysis of stable water isotopes and electrical conductivity, as well as the collection of discrete samples from both inner and outer parts of the core. This CFA system was designed to have sufficiently high temporal resolution to detect...... signals of abrupt climate change in deep polar ice cores. To test its performance, we used the system to analyze different climate intervals in ice drilled at the NEEM (North Greenland Eemian Ice Drilling) site, Greenland. The quality of our continuous measurement of stable water isotopes has been...

  4. Stability Analysis of the EBR-I Mark-II Core Meltdown Accident

    Lim, Jae-Yong; Kang, Chang Mu [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The purpose of this paper is to analyze the stability of the EBR-I core meltdown accident using the NuSTAB code. The result of NuSTAB analysis is compared with previous stability analysis by Sandmeier using the root locus method. The Experimental Breeder Reactor I (EBR-1) at Argonne National Laboratory was designed to demonstrate fast reactor breeding and to prove the use of liquid-metal coolant for power production and reached criticality in August 1951. The EBR-I reactor was undergoing a series of physics experiments and the Mark-II core was melted accidentally on Nov. 29, 1955. The experiment was going to increase core temperature to 500C to see if the reactor loses reactivity, and scram when the power reached 1500 kW or doubling of fission rate per second. However the operator scrammed with a slow moving control and missed the shutdown by two seconds and caused the core meltdown. The NuSTAB code has an advantage of analyzing space-dependent fast reactors and predicting regional oscillations compared to the point kinetics. Also, NuSTAB can be useful when the coupled neutronic-thermal-hydraulic codes cannot be used for stability analysis. Future work includes analyses of the PGSFR for various operating conditions as well as further validation of the NuSTAB calculations against SFR stability experiments when such experiments become available.

  5. Comparative Neutronics Analysis of DIMPLE S06 Criticality Benchmark with Contemporary Reactor Core Analysis Computer Code Systems

    Wonkyeong Kim


    Full Text Available A high-leakage core has been known to be a challenging problem not only for a two-step homogenization approach but also for a direct heterogeneous approach. In this paper the DIMPLE S06 core, which is a small high-leakage core, has been analyzed by a direct heterogeneous modeling approach and by a two-step homogenization modeling approach, using contemporary code systems developed for reactor core analysis. The focus of this work is a comprehensive comparative analysis of the conventional approaches and codes with a small core design, DIMPLE S06 critical experiment. The calculation procedure for the two approaches is explicitly presented in this paper. Comprehensive comparative analysis is performed by neutronics parameters: multiplication factor and assembly power distribution. Comparison of two-group homogenized cross sections from each lattice physics codes shows that the generated transport cross section has significant difference according to the transport approximation to treat anisotropic scattering effect. The necessity of the ADF to correct the discontinuity at the assembly interfaces is clearly presented by the flux distributions and the result of two-step approach. Finally, the two approaches show consistent results for all codes, while the comparison with the reference generated by MCNP shows significant error except for another Monte Carlo code, SERPENT2.

  6. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  7. An improved continuous flow analysis system for high-resolution field measurements on ice cores.

    Kaufmann, Patrik R; Federer, Urs; Hutterli, Manuel A; Bigler, Matthias; Schüpbach, Simon; Ruth, Urs; Schmitt, Jochen; Stocker, Thomas F


    Continuous flow analysis (CFA) is a well-established method to obtain information about impurity contents in ice cores as indicators of past changes in the climate system. A section of an ice core is continuously melted on a melter head supplying a sample water flow which is analyzed online. This provides high depth and time resolution of the ice core records and very efficient sample decontamination as only the inner part of the ice sample is analyzed. Here we present an improved CFA system which has been totally redesigned in view of a significantly enhanced overall efficiency and flexibility, signal quality, compactness, and ease of use. These are critical requirements especially for operations of CFA during field campaigns, e.g., in Antarctica or Greenland. Furthermore, a novel deviceto measure the total air content in the ice was developed. Subsequently, the air bubbles are now extracted continuously from the sample water flow for subsequent gas measurements.

  8. Analysis and experiment of eddy current loss in Homopolar magnetic bearings with laminated rotor cores

    Jinji, Sun; Dong, Chen


    This paper analyses the eddy current loss in Homopolar magnetic bearings with laminated rotor cores produced by the high speed rotation in order to reduce the power loss for the aerospace applications. The analytical model of rotational power loss is proposed in Homopolar magnetic bearings with laminated rotor cores considering the magnetic circuit difference between Homopolar and Heteropolar magnetic bearings. Therefore, the eddy current power loss can be calculated accurately using the analytical model by magnetic field solutions according to the distribution of magnetic fields around the pole surface and boundary conditions at the surface of the rotor cores. The measurement method of rotational power loss in Homopolar magnetic bearing is proposed, and the results of the theoretical analysis are verified by experiments in the prototype MSCMG. The experimental results show the correctness of calculation results.

  9. Optimization of high-resolution continuous flow analysis for transient climate signals in ice cores.

    Bigler, Matthias; Svensson, Anders; Kettner, Ernesto; Vallelonga, Paul; Nielsen, Maibritt E; Steffensen, Jørgen Peder


    Over the past two decades, continuous flow analysis (CFA) systems have been refined and widely used to measure aerosol constituents in polar and alpine ice cores in very high-depth resolution. Here we present a newly designed system consisting of sodium, ammonium, dust particles, and electrolytic meltwater conductivity detection modules. The system is optimized for high-resolution determination of transient signals in thin layers of deep polar ice cores. Based on standard measurements and by comparing sections of early Holocene and glacial ice from Greenland, we find that the new system features a depth resolution in the ice of a few millimeters which is considerably better than other CFA systems. Thus, the new system can resolve ice strata down to 10 mm thickness and has the potential of identifying annual layers in both Greenland and Antarctic ice cores throughout the last glacial cycle.

  10. Microbial Analysis of Australian Dry Lake Cores; Analogs For Biogeochemical Processes

    Nguyen, A. V.; Baldridge, A. M.; Thomson, B. J.


    Lake Gilmore in Western Australia is an acidic ephemeral lake that is analogous to Martian geochemical processes represented by interbedded phyllosilicates and sulfates. These areas demonstrate remnants of a global-scale change on Mars during the late Noachian era from a neutral to alkaline pH to relatively lower pH in the Hesperian era that continues to persist today. The geochemistry of these areas could possibly be caused by small-scale changes such as microbial metabolism. Two approaches were used to determine the presence of microbes in the Australian dry lake cores: DNA analysis and lipid analysis. Detecting DNA or lipids in the cores will provide evidence of living or deceased organisms since they provide distinct markers for life. Basic DNA analysis consists of extraction, amplification through PCR, plasmid cloning, and DNA sequencing. Once the sequence of unknown DNA is known, an online program, BLAST, will be used to identify the microbes for further analysis. The lipid analysis approach consists of phospholipid fatty acid analysis that is done by Microbial ID, which will provide direct identification any microbes from the presence of lipids. Identified microbes are then compared to mineralogy results from the x-ray diffraction of the core samples to determine if the types of metabolic reactions are consistent with the variation in composition in these analog deposits. If so, it provides intriguing implications for the presence of life in similar Martian deposits.

  11. 3D Finite element analysis of functionally graded multilayered dental ceramic cores.

    Al-Maqtari, Ali Abdullah; Razak, Abdul Aziz Abdul; Hamdi, Mohd


    This study aimed at investigating and establishing stress distributions in graded multilayered zirconia/alumina ceramic cores and at veneer-core-cement-dentin interfaces, using finite element analysis (FEA), to facilitate the structural design of ceramic cores through computer modeling. An intact maxillary premolar was digitized using CT scanning. An imaging software, Mimics, was used to reconstruct 3D models based on computed tomography (CT) data saved in DICOM format. Eight different 3D models were created for FEA, where each 3D model was meshed and its bottom boundaries constrained. A static load was applied in the oblique direction. The materials were assumed to be isotropic and homogeneous. Highest von Mises stress values were found in areas directly below the load application point, and stress gradually decreased in occlusal loading direction from the external surface toward the dentin. Stress levels occurring at veneer-ceramic core-cement-dentin interfaces were shown to be lower in multilayered ceramic cores than in single-layer models.

  12. Conceptual Core Analysis of Long Life PWR Utilizing Thorium-Uranium Fuel Cycle

    Rouf; Su'ud, Zaki


    Conceptual core analysis of long life PWR utilizing thorium-uranium based fuel has conducted. The purpose of this study is to evaluate neutronic behavior of reactor core using combined thorium and enriched uranium fuel. Based on this fuel composition, reactor core have higher conversion ratio rather than conventional fuel which could give longer operation length. This simulation performed using SRAC Code System based on library SRACLIB-JDL32. The calculation carried out for (Th-U)O2 and (Th-U)C fuel with uranium composition 30 - 40% and gadolinium (Gd2O3) as burnable poison 0,0125%. The fuel composition adjusted to obtain burn up length 10 - 15 years under thermal power 600 - 1000 MWt. The key properties such as uranium enrichment, fuel volume fraction, percentage of uranium are evaluated. Core calculation on this study adopted R-Z geometry divided by 3 region, each region have different uranium enrichment. The result show multiplication factor every burn up step for 15 years operation length, power distribution behavior, power peaking factor, and conversion ratio. The optimum core design achieved when thermal power 600 MWt, percentage of uranium 35%, U-235 enrichment 11 - 13%, with 14 years operation length, axial and radial power peaking factor about 1.5 and 1.2 respectively.

  13. PWR core and spent fuel pool analysis using scale and nestle

    Murphy, J. E.; Maldonado, G. I. [Dept. of Nuclear Engineering, Univ. of Tennessee, Knoxville, TN 37996-2300 (United States); St Clair, R.; Orr, D. [Duke Energy, 526 S. Church St, Charlotte, NC 28202 (United States)


    The SCALE nuclear analysis code system [SCALE, 2011], developed and maintained at Oak Ridge National Laboratory (ORNL) is widely recognized as high quality software for analyzing nuclear systems. The SCALE code system is composed of several validated computer codes and methods with standard control sequences, such as the TRITON/NEWT lattice physics sequence, which supplies dependable and accurate analyses for industry, regulators, and academia. Although TRITON generates energy-collapsed and space-homogenized few group cross sections, SCALE does not include a full-core nodal neutron diffusion simulation module within. However, in the past few years, the open-source NESTLE core simulator [NESTLE, 2003], originally developed at North Carolina State Univ. (NCSU), has been updated and upgraded via collaboration between ORNL and the Univ. of Tennessee (UT), so it now has a growingly seamless coupling to the TRITON/NEWT lattice physics [Galloway, 2010]. This study presents the methodology used to couple lattice physics data between TRITON and NESTLE in order to perform a three-dimensional full-core analysis employing a 'real-life' Duke Energy PWR as the test bed. The focus for this step was to compare the key parameters of core reactivity and radial power distribution versus plant data. Following the core analysis, following a three cycle burn, a spent fuel pool analysis was done using information generated from NESTLE for the discharged bundles and was compared to Duke Energy spent fuel pool models. The KENO control module from SCALE was employed for this latter stage of the project. (authors)

  14. Primary intramedullary neurocytoma: Case report and literature analysis

    Montano, Nicola; Di Bonaventura, Rina; Coli, Antonella; Fernandez, Eduardo; Meglio, Mario


    Background: Primary intramedullary neurocytoma is extremely rare. Due to its rarity, it is difficult to collect a wide series in a single institution to perform a survival analysis and give indications about prognosis and treatment. Case Description: Here, we report on a case of a 37-year-old woman with primary intramedullary neurocytoma and perform a systematic statistical analysis of cases reported in the literature. Of 21 articles found, 15 studies and the present case (22 patients) were eligible for the analysis. We studied the impact of age, sex, number of involved levels (≤2 vs. >2), entity of resection, postoperative radiotherapy (RT), proliferation index (Ki67) on the neurological outcome of patients, and on the recurrence of the tumor. Comparison of categorical variables was performed by the χ2 statistic. The Kaplan–Meier curves were plotted to calculate the progression-free survival (PFS) of these patients. P < 0.05 was considered as statistically significant. The 1-year PFS was 95.45% and the 2-year PFS was 86.36%. A gross total resection was associated to a worsening of the neurological function with no impact on the tumor recurrence. Adjuvant RT significantly improved the neurological function. A lower Ki67 was strongly associated with a lower tumor recurrence. Conclusions: We think that the goal of the surgery should be to preserve a good neurological function even if a residual tumor has to be left. Ki67 should be always evaluated due to its impact on the prognosis. Although adjuvant RT significantly improved the neurological function, its role in preventing the tumor recurrence is not clearly defined. PMID:26673057

  15. What are the core predictors of 'hassles among patients with multimorbidity in primary care? A cross sectional study

    Adeniji, Charles; Kenning, Cassandra; Coventry, Peter A; Bower, Peter


    Background A limitation of service delivery in primary care is that health care services are skewed towards improving care for patients with single long term conditions, whereas many older patients seen in the primary care nowadays have more than one condition. Qualitative research suggests that patients experience ‘hassles’ in their care, including multiple appointments, poor co-ordination, and conflicting recommendations. However, there is limited quantitative evidence on the ‘hassl...

  16. Analysis of treatment outcomes for primary tonsillar lymphoma

    Lee, Yun Hee [Dept. of Radiation Oncology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju (Korea, Republic of); Cho, Seok Goo; Jung, Seung Eun; Kim, Sung Hoon; O, Joo Hyun; Park, Gyeong Sin; Yang, Suk Woo; Lee, In Seok; Rhee, Chin; Kook; Choi, Byung Ock [Catholic University Lymphoma Group (CULG), Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)


    Although each Waldeyer’s ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed. Progression-free survival (PFS) and overall survival (OS) rates were analyzed. Most patients had Ann Arbor stage I-II (94.7%), IPI score of 0 (89.5%), and complete remission after chemotherapy (89.5%). The 5-year PFS and OS rates were 74.6% and 80%, respectively. In univariate analysis, the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen resulted in a better PFS than the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen (88.9% vs. 50.0%; p = 0.053). RT dose was related to the survival outcome (p = 0.010 for PFS, p = 0.044 for OS). Patients were classified into the CHOP + RT (>40 Gy) group and R-CHOP + RT (≤40 Gy) group. The 5-year PFS rates were 50% in the CHOP + RT group, and 100 % in the R-CHOP + RT group (p = 0.018). The 5-year OS rates were 66.7% and 100%, respectively (p = 0.087). Primary tonsillar lymphoma patients typically have favorable outcomes. Chemotherapy (R-CHOP) combined with relatively lower dose consolidative RT may be safe and effective for primary tonsillar lymphoma.

  17. Acceptance of lean redesigns in primary care: A contextual analysis.

    Hung, Dorothy; Gray, Caroline; Martinez, Meghan; Schmittdiel, Julie; Harrison, Michael I

    Lean is a leading change strategy used in health care to achieve short-term efficiency and quality improvement while promising longer-term system transformation. Most research examines Lean intervention to address isolated problems, rather than to achieve broader systemic changes to care delivery. Moreover, no studies examine contextual influences on system-wide Lean implementation efforts in primary care. The aim of this study was to identify contextual factors most critical to implementing and scaling Lean redesigns across all primary care clinics in a large, ambulatory care delivery system. Over 100 interviews and focus groups were conducted with frontline physicians, clinical staff, and operational leaders. Data analysis was guided by a modified Consolidated Framework for Implementation Research (CFIR), a popular implementation science framework. On the basis of expert recommendations, the modified framework targets factors influencing the implementation of process redesigns. This modified framework, the CFIR-PR, informed our identification of contextual factors that most impacted Lean acceptance among frontline physicians and staff. Several domains identified by the CFIR-PR were critical to acceptance of Lean redesigns. Regarding the implementation process acceptance was influenced by time and intensity of exposure to changes, "top-down" versus "bottom-up" implementation styles, and degrees of employee engagement in developing new workflows. Important factors in the inner setting were the clinic's culture and style of leadership, along with availability of information about Lean's effectiveness. Last, implementation efforts were impacted by individual and team characteristics regarding changed work roles and related issues of professional identity, authority, and autonomy. This study underscores the need for change leaders to consider the contextual factors that surround efforts to implement Lean in primary care. As Lean redesigns are scaled across a system

  18. Cost Analysis of Ceramic Heads in Primary Total Hip Arthroplasty.

    Carnes, Keith J; Odum, Susan M; Troyer, Jennifer L; Fehring, Thomas K


    The advent of adverse local tissue reactions seen in metal-on-metal bearings, and the recent recognition of trunnionosis, have led many surgeons to recommend ceramic-on-polyethylene articulations for primary total hip arthroplasty. However, to our knowledge, there has been little research that has considered whether the increased cost of ceramic provides enough benefit over cobalt-chromium to justify its use. The primary purpose of this study was to compare the cost-effectiveness of ceramic-on-polyethylene implants and metal-on-polyethylene implants in patients undergoing total hip arthroplasty. Markov decision modeling was used to determine the ceramic-on-polyethylene implant revision rate necessary to be cost-effective compared with the revision rate of metal-on-polyethylene implants across a range of patient ages and implant costs. A different set of Markov models was used to estimate the national cost burden of choosing ceramic-on-polyethylene implants over metal-on-polyethylene implants for primary total hip arthroplasties. The Premier Research Database was used to identify 20,398 patients who in 2012 were ≥45 years of age and underwent a total hip arthroplasty with either a ceramic-on-polyethylene implant or a metal-on-polyethylene implant. The cost-effectiveness of ceramic heads is highly dependent on the cost differential between ceramic and metal femoral heads and the age of the patient. At a cost differential of $325, ceramic-on-polyethylene bearings are cost-effective for patients price premium for ceramic and the age of the patient. A wholesale switch to ceramic bearings regardless of age or cost differential may result in an economic burden to the health system. Economic and decision analysis, Level III. See Instructions for Authors for a complete description of levels of evidence. Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated.

  19. Analysis of microleakage of temporary restorative materials in primary teeth

    Geórgia Linhares dos Santos


    Full Text Available Aim: The aim of this study was to compare the coronal microleakage of restorative materials used between sessions of endodontic treatment in primary teeth. Materials and Methods: Forty healthy primary canines were chosen and randomly allocated to four groups: Group 1 - Cimpat Branco ® (n = 10, Group 2 - Bioplic ® (n = 10, Group 3 - Maxxion R ® glass ionomer cement (n = 10, and Group 4 (control - Z350 ® composite resin (n = 10. Class V cavities were created and fillings carried out following the manufacturer′s instructions. The teeth were submitted to thermocycling, sealed, and immersed in 0.5% basic fuchsin solution for 24 h. The teeth were split along their long axis in the vestibulolingual direction and the tooth-restorative material interface was photographed. The percentage of microleakage was calculated using the ImageJ program. Data were analyzed using the analysis of variance (ANOVA F-test and Bonferroni′s t-test, with a 5% level of significance. Results: The following mean percentages of microleakage were found: Group 1 = 16.08%, Group 2 = 46.98%, Group 3 = 47.93%, and Group 4 = 11.03%. Statistically, significant differences were found in the comparison of Groups 1 and 4 to Groups 2 and 3. Conclusion: Cimpat Branco ® had a lower percentage of microleakage in comparison to Bioplic ® and Maxxion R ® glass ionomer cement.

  20. Promoting Utilization of Saccharum spp. Genetic Resources through Genetic Diversity Analysis and Core Collection Construction

    Pathak, Bhuvan; Ayala-Silva, Tomas; Yang, Xiping; Todd, James; Glynn, Neil C.; Kuhn, David N.; Glaz, Barry; Gilbert, Robert A.; Comstock, Jack C.; Wang, Jianping


    Sugarcane (Saccharum spp.) and other members of Saccharum spp. are attractive biofuel feedstocks. One of the two World Collections of Sugarcane and Related Grasses (WCSRG) is in Miami, FL. This WCSRG has 1002 accessions, presumably with valuable alleles for biomass, other important agronomic traits, and stress resistance. However, the WCSRG has not been fully exploited by breeders due to its lack of characterization and unmanageable population. In order to optimize the use of this genetic resource, we aim to 1) genotypically evaluate all the 1002 accessions to understand its genetic diversity and population structure and 2) form a core collection, which captures most of the genetic diversity in the WCSRG. We screened 36 microsatellite markers on 1002 genotypes and recorded 209 alleles. Genetic diversity of the WCSRG ranged from 0 to 0.5 with an average of 0.304. The population structure analysis and principal coordinate analysis revealed three clusters with all S. spontaneum in one cluster, S. officinarum and S. hybrids in the second cluster and mostly non-Saccharum spp. in the third cluster. A core collection of 300 accessions was identified which captured the maximum genetic diversity of the entire WCSRG which can be further exploited for sugarcane and energy cane breeding. Sugarcane and energy cane breeders can effectively utilize this core collection for cultivar improvement. Further, the core collection can provide resources for forming an association panel to evaluate the traits of agronomic and commercial importance. PMID:25333358

  1. Promoting utilization of Saccharum spp. genetic resources through genetic diversity analysis and core collection construction.

    Spurthi N Nayak

    Full Text Available Sugarcane (Saccharum spp. and other members of Saccharum spp. are attractive biofuel feedstocks. One of the two World Collections of Sugarcane and Related Grasses (WCSRG is in Miami, FL. This WCSRG has 1002 accessions, presumably with valuable alleles for biomass, other important agronomic traits, and stress resistance. However, the WCSRG has not been fully exploited by breeders due to its lack of characterization and unmanageable population. In order to optimize the use of this genetic resource, we aim to 1 genotypically evaluate all the 1002 accessions to understand its genetic diversity and population structure and 2 form a core collection, which captures most of the genetic diversity in the WCSRG. We screened 36 microsatellite markers on 1002 genotypes and recorded 209 alleles. Genetic diversity of the WCSRG ranged from 0 to 0.5 with an average of 0.304. The population structure analysis and principal coordinate analysis revealed three clusters with all S. spontaneum in one cluster, S. officinarum and S. hybrids in the second cluster and mostly non-Saccharum spp. in the third cluster. A core collection of 300 accessions was identified which captured the maximum genetic diversity of the entire WCSRG which can be further exploited for sugarcane and energy cane breeding. Sugarcane and energy cane breeders can effectively utilize this core collection for cultivar improvement. Further, the core collection can provide resources for forming an association panel to evaluate the traits of agronomic and commercial importance.

  2. Promoting utilization of Saccharum spp. genetic resources through genetic diversity analysis and core collection construction.

    Nayak, Spurthi N; Song, Jian; Villa, Andrea; Pathak, Bhuvan; Ayala-Silva, Tomas; Yang, Xiping; Todd, James; Glynn, Neil C; Kuhn, David N; Glaz, Barry; Gilbert, Robert A; Comstock, Jack C; Wang, Jianping


    Sugarcane (Saccharum spp.) and other members of Saccharum spp. are attractive biofuel feedstocks. One of the two World Collections of Sugarcane and Related Grasses (WCSRG) is in Miami, FL. This WCSRG has 1002 accessions, presumably with valuable alleles for biomass, other important agronomic traits, and stress resistance. However, the WCSRG has not been fully exploited by breeders due to its lack of characterization and unmanageable population. In order to optimize the use of this genetic resource, we aim to 1) genotypically evaluate all the 1002 accessions to understand its genetic diversity and population structure and 2) form a core collection, which captures most of the genetic diversity in the WCSRG. We screened 36 microsatellite markers on 1002 genotypes and recorded 209 alleles. Genetic diversity of the WCSRG ranged from 0 to 0.5 with an average of 0.304. The population structure analysis and principal coordinate analysis revealed three clusters with all S. spontaneum in one cluster, S. officinarum and S. hybrids in the second cluster and mostly non-Saccharum spp. in the third cluster. A core collection of 300 accessions was identified which captured the maximum genetic diversity of the entire WCSRG which can be further exploited for sugarcane and energy cane breeding. Sugarcane and energy cane breeders can effectively utilize this core collection for cultivar improvement. Further, the core collection can provide resources for forming an association panel to evaluate the traits of agronomic and commercial importance.

  3. An analysis of the proposed MITR-III core to establish thermal-hydraulic limits at 10 MW. Final report

    Harling, O.K.; Lanning, D.D.; Bernard, J.A.; Meyer, J.E.; Henry, A.F.


    The 5 MW Massachusetts Institute of Technology Research Reactor (MITR-II) is expected to operate under a new license beginning in 1999. Among the options being considered is an upgrade in the heat removal system to allow operation at 10 MW. The purpose of this study is to predict the Limiting Safety System Settings and Safety Limits for the upgraded reactor (MITR-III). The MITR Multi-Channel Analysis Code was written to analyze the response of the MITR system to a series of anticipated transients in order to determine the Limiting Safety System Settings and Safety Limits under various operating conditions. The MIT Multi-Channel Analysis Code models the primary and secondary systems, with special emphasis placed on analyzing the thermal-hydraulic conditions in the core. The code models each MITR fuel element explicitly in order to predict the behavior of the system during flow instabilities. The results of the code are compared to experimental data from MITR-II and other sources. New definitions are suggested for the Limiting Safety System Settings and Safety Limits. MITR Limit Diagrams are included for three different heat removal system configurations. It is concluded that safe, year-round operating at 10 MW is possible, given that the primary and secondary flow rates are both increased by approximately 40%.

  4. A meta-analysis of core stability exercise versus general exercise for chronic low back pain.

    Wang, Xue-Qiang; Zheng, Jie-Jiao; Yu, Zhuo-Wei; Bi, Xia; Lou, Shu-Jie; Liu, Jing; Cai, Bin; Hua, Ying-Hui; Wu, Mark; Wei, Mao-Ling; Shen, Hai-Min; Chen, Yi; Pan, Yu-Jian; Xu, Guo-Hui; Chen, Pei-Jie


    To review the effects of core stability exercise or general exercise for patients with chronic low back pain (LBP). Exercise therapy appears to be effective at decreasing pain and improving function for patients with chronic LBP in practice guidelines. Core stability exercise is becoming increasingly popular for LBP. However, it is currently unknown whether core stability exercise produces more beneficial effects than general exercise in patients with chronic LBP. Published articles from 1970 to October 2011 were identified using electronic searches. For this meta-analysis, two reviewers independently selected relevant randomized controlled trials (RCTs) investigating core stability exercise versus general exercise for the treatment of patients with chronic LBP. Data were extracted independently by the same two individuals who selected the studies. From the 28 potentially relevant trials, a total of 5 trials involving 414 participants were included in the current analysis. The pooling revealed that core stability exercise was better than general exercise for reducing pain [mean difference (-1.29); 95% confidence interval (-2.47, -0.11); P = 0.003] and disability [mean difference (-7.14); 95% confidence interval (-11.64, -2.65); P = 0.002] at the time of the short-term follow-up. However, no significant differences were observed between core stability exercise and general exercise in reducing pain at 6 months [mean difference (-0.50); 95% confidence interval (-1.36, 0.36); P = 0.26] and 12 months [mean difference (-0.32); 95% confidence interval (-0.87, 0.23); P = 0.25]. Compared to general exercise, core stability exercise is more effective in decreasing pain and may improve physical function in patients with chronic LBP in the short term. However, no significant long-term differences in pain severity were observed between patients who engaged in core stability exercise versus those who engaged in general exercise. http

  5. Video Analysis of Primary Shoulder Dislocations in Rugby Tackles

    Maki, Nobukazu; Kawasaki, Takayuki; Mochizuki, Tomoyuki; Ota, Chihiro; Yoneda, Takeshi; Urayama, Shingo; Kaneko, Kazuo


    Background: Characteristics of rugby tackles that lead to primary anterior shoulder dislocation remain unclear. Purpose: To clarify the characteristics of tackling that lead to shoulder dislocation and to assess the correlation between the mechanism of injury and morphological damage of the glenoid. Study Design: Case series; Level of evidence, 4. Methods: Eleven elite rugby players who sustained primary anterior shoulder dislocation due to one-on-one tackling between 2001 and 2014 were included. Using an assessment system, the tackler’s movement, posture, and shoulder and head position were evaluated in each phase of tackling. Based on 3-dimensional computed tomography, the glenoid of the affected shoulder was classified into 3 types: intact, erosion, and bone defect. Orientation of the glenoid defect and presence of Hill-Sachs lesion were also evaluated. Results: Eleven tackles that led to primary shoulder dislocation were divided into hand, arm, and shoulder tackle types based on the site at which the tackler contacted the ball carrier initially. In hand and arm tackles, the tackler’s shoulder joint was forcibly moved to horizontal abduction by the impact of his upper limb, which appeared to result from an inappropriate approach to the ball carrier. In shoulder tackles, the tackler’s head was lowered and was in front of the ball carrier at impact. There was no significant correlation between tackle types and the characteristics of bony lesions of the shoulder. Conclusion: Although the precise mechanism of primary anterior shoulder dislocation could not be estimated from this single-view analysis, failure of individual tackling leading to injury is not uniform and can be caused by 2 main factors: failure of approach followed by an extended arm position or inappropriate posture of the tackler at impact, such as a lowered head in front of the opponent. These findings indicate that injury mechanisms should be assessed for each type of tackle, as it is unknown


    CHOU Chin-shan; LIU Bao-yan; ZHANG Lu; JIN Zhi-gao


    Recent literature search showed that up to now there are a total of 9 theses about clinical treatment of primary dysmenorrhea with acupuncture therapy, among them 5 clinical trials are from Chinese journals and the rest 4 from foreign journals. Majority of the trials have some methodological and/or reporting shortcomings. The frequency and intensity of dysmenorrhea are divided into intermittent and continuous types. Results of quantitative meta-analysis with Revman 4.1 software showed that the existing evidence supports the value of acupuncture for the treatment of dysmenorrhea. However, the quality of evidence is not fully convincing. There is an urgent need for well-planned, large-scale and multiple-center studies to assess the effectiveness and cost-effectiveness of acupuncture under real-life conditions.

  7. A Monte Carlo study to measure the energy spectra of the primary cosmic-ray components at the knee using a new Tibet AS core detector array

    :,; Bi, X J; Chen, D; Chen, W Y; Cui, S W; Danzengluobu,; Ding, L K; Ding, X H; Feng, C F; Feng, Zhaoyang; Feng, Z Y; Gou, Q B; Guo, H W; Guo, Y Q; He, H H; He, Z T; Hibino, K; Hotta, N; Hu, Haibing; Hu, H B; Huang, J; Li, W J; Jia, H Y; Jiang, L; Kajino, F; Kasahara, K; Katayose, Y; Kato, C; Kawata, K; Labaciren,; Le, G M; Li, A F; Liu, C; Liu, J S; Lu, H; Meng, X R; Mizutani, K; Munakata, K; Nanjo, H; Nishizawa, M; Ohnishi, M; Ohta, I; Ozawa, S; Qian, X L; Qu, X B; Saito, T; Saito, T Y; Sakata, M; Sako, T K; Shao, J; Shibata, M; Shiomi, A; Shirai, T; Sugimoto, H; Takita, M; Tan, Y H; Tateyama, N; Torii, S; Tsuchiya, H; Udo, S; Wang, H; Wu, H R; Xue, L; Yamamoto, Y; Yang, Z; Yasue, S; Yuan, A F; Yuda, T; Zhai, L M; Zhang, H M; Zhang, J L; Zhang, X Y; Zhang, Y; Zhang, Yi; Zhang, Ying; Zhaxisangzhu,; Zhou, X X


    A new hybrid experiment has been started by AS{\\gamma} experiment at Tibet, China, since August 2011, which consists of a low threshold burst-detector-grid (YAC-II, Yangbajing Air shower Core array), the Tibet air-shower array (Tibet-III) and a large underground water Cherenkov muon detector (MD). In this paper, the capability of the measurement of the chemical components (proton, helium and iron) with use of the (Tibet-III+YAC-II) is investigated by means of an extensive Monte Carlo simulation in which the secondary particles are propagated through the (Tibet-III+YAC-II) array and an artificial neural network (ANN) method is applied for the primary mass separation. Our simulation shows that the new installation is powerful to study the chemical compositions, in particular, to obtain the primary energy spectrum of the major component at the knee.

  8. Weibull analysis and flexural strength of hot-pressed core and veneered ceramic structures.

    Bona, Alvaro Della; Anusavice, Kenneth J; DeHoff, Paul H


    To test the hypothesis that the Weibull moduli of single- and multilayer ceramics are controlled primarily by the structural reliability of the core ceramic.Methods. Seven groups of 20 bar specimens (25 x 4 x 1.2 mm) were made from the following materials: (1) IPS Empress--a hot-pressed (HP) leucite-based core ceramic; (2) IPS Empress2--a HP lithia-based core ceramic; (3 and 7) Evision--a HP lithia-based core ceramic (ES); (4) IPS Empress2 body--a glass veneer; (5) ES (1.1 mm thick) plus a glaze layer (0.1 mm); and (6) ES (0.8 mm thick) plus veneer (0.3 mm) and glaze (0.1 mm). Each specimen was subjected to four-point flexure loading at a cross-head speed of 0.5 mm/min while immersed in distilled water at 37 degrees C, except for Group 7 that was tested in a dry environment. Failure loads were recorded and the fracture surfaces were examined using SEM. ANOVA and Duncan's multiple range test were used for statistical analysis. No significant differences were found between the mean flexural strength values of Groups 2, 3, 5, and 6 or between Groups 1 and 4 (p>0.05). However, significant differences were found for dry (Group 7) and wet (Groups 1-6) conditions. Glazing had no significant effect on the flexural strength or Weibull modulus. The strength and Weibull modulus of the ES ceramic were similar to those of Groups 5 and 6. The structural reliability of veneered core ceramic is controlled primarily by that of the core ceramic.

  9. Quantification of LOCA core damage frequency based on thermal-hydraulics analysis

    Cho, Jaehyun, E-mail:; Park, Jin Hee; Kim, Dong-San; Lim, Ho-Gon


    Highlights: • We quantified the LOCA core damage frequency based on the best-estimated success criteria analysis. • The thermal-hydraulic analysis using MARS code has been applied to Korea Standard Nuclear Power Plants. • Five new event trees with new break size boundaries and new success criteria were developed. • The core damage frequency is 5.80E−07 (/y), which is 12% less than the conventional PSA event trees. - Abstract: A loss-of-coolant accident (LOCA) has always been significantly considered one of the most important initiating events. However, most probabilistic safety assessment models, up to now, have undoubtedly adopted the three groups of LOCA, and even an exact break size boundary that used in WASH-1400 reports was published in 1975. With an awareness of the importance of a realistic PSA for a risk-informed application, several studies have tried to find the realistic thermal-hydraulic behavior of a LOCA, and improve the PSA model. The purpose of this research is to obtain realistic results of the LOCA core damage frequency based on a success criteria analysis using the best-estimate thermal-hydraulics code. To do so, the Korea Standard Nuclear Power Plant (KSNP) was selected for this study. The MARS code was used for a thermal hydraulics analysis and the AIMS code was used for the core damage quantification. One of the major findings in the thermal hydraulics analysis was that the decay power is well removed by only a normal secondary cooling in LOCAs of below 1.4 in and by only a high pressure safety injection in LOCAs of 0.8–9.4 in. Based on the thermal hydraulics results regarding new break size boundaries and new success criteria, five new event trees (ETs) were developed. The core damage frequency of new LOCA ETs is 5.80E−07 (/y), which is 12% less than the conventional PSA ETs. In this research, we obtained not only thermal-hydraulics characteristics for the entire break size of a LOCA in view of the deterministic safety

  10. CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

    Pasculescu, Adrian; Schoof, Erwin M; Creixell, Pau; Zheng, Yong; Olhovsky, Marina; Tian, Ruijun; So, Jonathan; Vanderlaan, Rachel D; Pawson, Tony; Linding, Rune; Colwill, Karen


    A major challenge in mass spectrometry and other large-scale applications is how to handle, integrate, and model the data that is produced. Given the speed at which technology advances and the need to keep pace with biological experiments, we designed a computational platform, CoreFlow, which provides programmers with a framework to manage data in real-time. It allows users to upload data into a relational database (MySQL), and to create custom scripts in high-level languages such as R, Python, or Perl for processing, correcting and modeling this data. CoreFlow organizes these scripts into project-specific pipelines, tracks interdependencies between related tasks, and enables the generation of summary reports as well as publication-quality images. As a result, the gap between experimental and computational components of a typical large-scale biology project is reduced, decreasing the time between data generation, analysis and manuscript writing. CoreFlow is being released to the scientific community as an open-sourced software package complete with proteomics-specific examples, which include corrections for incomplete isotopic labeling of peptides (SILAC) or arginine-to-proline conversion, and modeling of multiple/selected reaction monitoring (MRM/SRM) results. CoreFlow was purposely designed as an environment for programmers to rapidly perform data analysis. These analyses are assembled into project-specific workflows that are readily shared with biologists to guide the next stages of experimentation. Its simple yet powerful interface provides a structure where scripts can be written and tested virtually simultaneously to shorten the life cycle of code development for a particular task. The scripts are exposed at every step so that a user can quickly see the relationships between the data, the assumptions that have been made, and the manipulations that have been performed. Since the scripts use commonly available programming languages, they can easily be

  11. Primary hepatic angiosarcoma:a clinical and pathological analysis



    Objective To investigate the clinicopathological characteristics,differential diagnosis,and prognosis of primary hepatic angiosarcoma,and to review the literature.Methods Twenty cases of primary hepatic angiosarcoma were analyzed by gross examination and light

  12. Core-scale solute transport model selection using Monte Carlo analysis

    Malama, Bwalya; James, Scott C


    Model applicability to core-scale solute transport is evaluated using breakthrough data from column experiments conducted with conservative tracers tritium (H-3) and sodium-22, and the retarding solute uranium-232. The three models considered are single-porosity, double-porosity with single-rate mobile-immobile mass-exchange, and the multirate model, which is a deterministic model that admits the statistics of a random mobile-immobile mass-exchange rate coefficient. The experiments were conducted on intact Culebra Dolomite core samples. Previously, data were analyzed using single- and double-porosity models although the Culebra Dolomite is known to possess multiple types and scales of porosity, and to exhibit multirate mobile-immobile-domain mass transfer characteristics at field scale. The data are reanalyzed here and null-space Monte Carlo analysis is used to facilitate objective model selection. Prediction (or residual) bias is adopted as a measure of the model structural error. The analysis clearly shows ...

  13. 2D analysis of polydisperse core-shell nanoparticles using analytical ultracentrifugation.

    Walter, Johannes; Gorbet, Gary; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang


    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core-shell NPs by means of analytical ultracentrifugation (AUC) is addressed. AUC is one of the most accurate techniques for the characterization of NPs in the liquid phase because it can resolve particle size distributions (PSDs) with unrivaled resolution and detail. Small NPs have to be considered as core-shell systems when dispersed in a liquid since a solvation layer and a stabilizer shell will significantly contribute to the particle's hydrodynamic diameter and effective density. AUC measures the sedimentation and diffusion transport of the analytes, which are affected by the core-shell compositional properties. This work demonstrates that polydisperse and thus widely distributed NPs pose significant challenges for current state-of-the-art data evaluation methods. The existing methods either have insufficient resolution or do not correctly reproduce the core-shell properties. First, we investigate the performance of different data evaluation models by means of simulated data. Then, we propose a new methodology to address the core-shell properties of NPs. This method is based on the parametrically constrained spectrum analysis and offers complete access to the size and effective density of polydisperse NPs. Our study is complemented using experimental data derived for ZnO and CuInS2 NPs, which do not have a monodisperse PSD. For the first time, the size and effective density of such structures could be resolved with high resolution by means of a two-dimensional AUC analysis approach.

  14. Development of a computer code for dynamic analysis of the primary circuit of advanced reactors

    Rocha, Jussie Soares da; Lira, Carlos A.B.O.; Magalhaes, Mardson A. de Sa, E-mail: cabol@ufpe.b [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear


    Currently, advanced reactors are being developed, seeking for enhanced safety, better performance and low environmental impacts. Reactor designs must follow several steps and numerous tests before a conceptual project could be certified. In this sense, computational tools become indispensable in the preparation of such projects. Thus, this study aimed at the development of a computational tool for thermal-hydraulic analysis by coupling two computer codes to evaluate the influence of transients caused by pressure variations and flow surges in the region of the primary circuit of IRIS reactor between the core and the pressurizer. For the simulation, it was used a situation of 'insurge', characterized by the entry of water in the pressurizer, due to the expansion of the refrigerant in the primary circuit. This expansion was represented by a pressure disturbance in step form, through the block 'step' of SIMULINK, thus enabling the transient startup. The results showed that the dynamic tool, obtained through the coupling of the codes, generated very satisfactory responses within model limitations, preserving the most important phenomena in the process. (author)

  15. CFD analysis of PWR core top and reactor vessel upper plenum internal subdomain models

    Kao, Min-Tsung; Wu, Chung-Yun [National Tsing Hua University, Hsinchu 30043, Taiwan (China); Chieng, Ching-Chang, E-mail: [National Tsing Hua University, Hsinchu 30043, Taiwan (China); Xu Yiban; Yuan Kun; Dzodzo, Milorad; Conner, Michael; Beltz, Steven; Ray, Sumit; Bissett, Teresa [Westinghouse Electric Company, Cranberry Township, PA 16066 (United States)


    , CFD analysis is presented for two subdomain models: the top core region and control rod guide tube region. These models are chosen for simulation because guide tube and top core region (including top grid, top nozzle, and hold-down device) are the major components of upper plenum effecting the flow patterns and pressure distribution. The top core region, corresponding to 1/4 of fuel assembly, includes components as upper part of the fuel assemblies (top grid, fuel rods, top nozzle), core component hold-down devices, and upper core plates. These components distribute the core flow to different sections of guidetube regions. Mesh sensitivity studies have been conducted for each individual part in order to determine the proper geometrical simplifications. Pressure drop measurement data are compared with the predicted CFD results and act as a guideline for the mesh selection. The guidetube region includes control rod guidetubes themselves, adjacent support columns and open regions. In this study, two models of subdomains are analyzed: (1) a 1/4 section of one control rod guide tube by itself and (2) a representative unit cell containing two 1/4 sections of adjacent control rod guide tubes and one 1/4 section of a neighboring support column. Predicted flow rates at each of the outflow locations in conjunction with results from the mesh sensitivity studies provide guidance on (1) what geometry to preserve or remove, (2) what geometry can be simplified to reduce the required mesh, and (3) an estimate of the total mesh required to model the entire upper plenum and top fuel domain. The commercial CFD code STAR-CCM+ is employed to generate the computational mesh, to solve the Reynolds-averaged Navier-Stokes equations for incompressible flow with a Realizable k-{epsilon} turbulence model, and to post-process the results.

  16. Flow regimes and heat transfer modes identification in ANGRA 2 core, during small break in the primary loop with area of 100 cm{sup 2}, simulated with RELAP5 code

    Borges, Eduardo M.; Sabundjian, Gaiane, E-mail:, E-mail: [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)


    Identifying the flow regimes and the heat transfer modes is important for the analysis of accidents such as the Loss-of-Coolant Accident (LOCA). The aim of this paper is to identify the flow regimes, the heat transfer modes, and the correlations used in the RELAP5/MOD3.2.gama code in ANGRA 2 during the Small-Break Loss-of-Coolant Accident (SBLOCA) with a 100cm{sup 2}-rupture area in the cold leg of primary loop. The Chapter 15 of the Final Safety Analysis Report of ANGRA 2 (FSAR - A2) reports this specific kind of accident. The results from this work demonstrated the several flow regimes and heat transfer modes that can be present in the core of ANGRA 2 during the postulated accident. (author)

  17. Petrographic Analysis of Portland Cement Concrete Cores from Pease Air National Guard Base, New Hampshire


    Petrographic Analysis of Portland Cement Concrete Cores from Pease Air National Guard Base, New Hampshire E n g in e e r R e s e a rc h a n, age of the concrete being evaluated and tests performed...4 3 Preface This study was conducted in support of the Air Force Civil Engineer Center (AFCEC) to assess concrete obtained from Pease

  18. Numerical analysis of sandwich beam with corrugated core under three-point bending

    Wittenbeck, Leszek [Poznan University of Technology, Institute of Mathematics Piotrowo Street No. 5, 60-965 Poznan (Poland); Grygorowicz, Magdalena; Paczos, Piotr [Poznan University of Technology, Institute of Applied Mechanics Jana Pawla IIStreet No. 24, 60-965 Poznan (Poland)


    The strength problem of sandwich beam with corrugated core under three-point bending is presented.The beam are made of steel and formed by three mutually orthogonal corrugated layers. The finite element analysis (FEA) of the sandwich beam is performed with the use of the FEM system - ABAQUS. The relationship between the applied load and deflection in three-point bending is considered.

  19. Analysis of Core Degradation in Fukushima Unit 1 Accident with MELCOR

    Kim, Sung Il; Kim, Tae Woon; Ha, Kwang Soon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    In this study, an accident analysis of Fukushima Daiichi Unit 1 was performed using MELCOR 1.8.6. The behavior of the initial stage of the accident was focused during 30 hours after the reactor scram, because it was predicted that the vessel failure (severe accident) occurred before 20 hours. A hydrogen explosion also occurred at about 24 hours after the accident, and thus the phenomenon of core degradation before 30 hours was highlighted. Moreover, the effect of the amount of fresh water injection on the core degradation was performed by changing the amount of injection water. It was expected that a large portion of the injection water could not reach the core because of leakage. Thus, core damage was observed according to the amount of water that reached the core. The plant geometries and operating conditions were obtained from TEPCO (Tokyo Electric Power Company) through the OECD/NEA BSAF (Benchmark Study of the Accident at the Fukushima Daiichi Nuclear Power Station) Project. An analysis of the Fukushima accident was also performed by Sandia National Laboratories, but several conditions were revised and added in this study. First, the flow rate of the steam into turbine and water into downcomer were considered at the initial stage of accident. The water level followed well the measured data by adding this mechanism. Second, SRV stuck open was included in this calculation. SRV stuck open can occur due to high temperature and frequent operation, and was modeled in calculation. The timing of SRV stuck open was closed to the timing of MSL failure, and thus the depressurization of RPV could have originated from both of MSL failure and SRV stuck open. The effect of injection water was observed, and it was found that the proper water injection can prevent a severe accident at the initial stage of the accident. In conclusion, an analysis of the severe accident occurring in Fukushima Unit 1 was conducted by using MELCOR. The analysis results were consistent with the

  20. Improved methodologies for continuous-flow analysis of stable water isotopes in ice cores

    Jones, Tyler R.; White, James W. C.; Steig, Eric J.; Vaughn, Bruce H.; Morris, Valerie; Gkinis, Vasileios; Markle, Bradley R.; Schoenemann, Spruce W.


    Water isotopes in ice cores are used as a climate proxy for local temperature and regional atmospheric circulation as well as evaporative conditions in moisture source regions. Traditional measurements of water isotopes have been achieved using magnetic sector isotope ratio mass spectrometry (IRMS). However, a number of recent studies have shown that laser absorption spectrometry (LAS) performs as well or better than IRMS. The new LAS technology has been combined with continuous-flow analysis (CFA) to improve data density and sample throughput in numerous prior ice coring projects. Here, we present a comparable semi-automated LAS-CFA system for measuring high-resolution water isotopes of ice cores. We outline new methods for partitioning both system precision and mixing length into liquid and vapor components - useful measures for defining and improving the overall performance of the system. Critically, these methods take into account the uncertainty of depth registration that is not present in IRMS nor fully accounted for in other CFA studies. These analyses are achieved using samples from a South Pole firn core, a Greenland ice core, and the West Antarctic Ice Sheet (WAIS) Divide ice core. The measurement system utilizes a 16-position carousel contained in a freezer to consecutively deliver ˜ 1 m × 1.3 cm2 ice sticks to a temperature-controlled melt head, where the ice is converted to a continuous liquid stream and eventually vaporized using a concentric nebulizer for isotopic analysis. An integrated delivery system for water isotope standards is used for calibration to the Vienna Standard Mean Ocean Water (VSMOW) scale, and depth registration is achieved using a precise overhead laser distance device with an uncertainty of ±0.2 mm. As an added check on the system, we perform inter-lab LAS comparisons using WAIS Divide ice samples, a corroboratory step not taken in prior CFA studies. The overall results are important for substantiating data obtained from LAS

  1. Analysis of a German BWR core with TRACE/PARCS using different cross section sets

    Hartmann, C., E-mail: [Karlsruhe Inst. of Tech. (KIT), Inst. for Neutron Physics and Reactor Technology (INR), Eggenstein-Leopoldshafen (Germany); Westinghouse Electric Germany GmbH, Mannheim (Germany); Sanchez, V.H. [Karlsruhe Inst. of Tech. (KIT), Inst. for Neutron Physics and Reactor Technology (INR), Eggenstein-Leopoldshafen (Germany); Tietsch, W. [Westinghouse Electric Germany GmbH, Mannheim (Germany)


    'Full text:' Coupled Thermal-hydraulic/Neutron-kinetic (TH/NK) simulations of Boiling Water Reactor transients require well validated and accurate simulation tools as well as appropriate cross sections (XS) libraries depending on the individual thermal hydraulic state parameters. Problem-dependent XS-sets for 3D core simulations are being generated mainly by well validated, fast running and user-friendly lattice codes such as Casco and Helios. At research institutions and universities, alternative tools to the commercial ones with full access to the source code as well as moderate cost are urgently needed. The Scale system is being developed and improved for lattice physics calculations of real core loading of Light Water Reactors (LWR). It represents a promising alternative to the commercial lattice codes. At Karlsruhe Institute of Technology (Kit) a computational route based on Scale/Triton/Newt for BWR core loading is under development. The generated XS-data sets have to be transformed in PMAXS-format for use in the reactor dynamic code PARCS. This task is performed by the module GenPMAXS being developed and tested at the Michigan University. To verify the computational route, a BWR fuel assembly depletion problem was calculated by PARCS and compared to the CASMO results. Since the SCALE/TRITON XS-file does actually not contain all required neutronic data, FORTRAN routines have been developed to incorporate the missing data e.g. the yields of Iodine, Xenon and Promethium into the XS-data sets in the PMAXS-format. The comparison of the results obtained with PARCS (using the corrected PMAXS file) and CASMO for the depletion problem exhibited a good agreement. Consequently, this approach was followed for the generation of a complete XS-set for a real BWR core to be used in subsequent transient analysis. Then 3D neutronic and thermal hydraulic core model were elaborated for a TRACE/PARCS analysis. The thermal hydraulic model is based on the 3D VESSEL

  2. Fundamental Frequency Analysis of Sandwich Beams with Functionally Graded Face and Metallic Foam Core

    Lin Mu


    Full Text Available This study is interested in assessing a way to analyze fundamental frequency of sandwich beams with functionally graded face sheet and homogeneous core. The face sheet, which is an exponentially graded material (EGM varying smoothly in the thickness direction only, is composed of a mixture of metal and ceramic. The core which is made of foam metal is homogeneous. The classical plate theory (CPT is used to analyze the face sheet and a higher-order theory (HOT is used to analyze the core of sandwich beams, in which both the transverse normal and shear strains of the core are considered. The extended Galerkin method is used to solve the governing equations to obtain the vibration equations of the sandwich beams suitable for numerical analysis. The fundamental frequency obtained by the theoretical model is validated by using the finite element code ABAQUS and comparison with earlier works. The influences of material and geometric properties on the fundamental frequency of the sandwich beams are analyzed.

  3. Core and Conal Component Analysis of Pulsar B1237+25

    Srostlik, Z; Srostlik, Zuzana; Rankin, Joanna M.


    The paper provides a new analysis of this famous five-component ({\\bf M}) pulsar. In addition to the star's core-active ``abnormal'' mode, we find two distinct behaviors within its ``normal'' mode, a ``quiet-normal'' mode with regular 2.8-period subpulse modulation and little or no core activity, and a ``flare-normal'' mode, where the core is regularly bright and a nearly 4-period modulation is maintained. The ``flare-normal'' mode appears to be an intermediate state between the ``quiet normal'' and ``abnormal'' behaviors. Short 5--15-pulse ``flare-normal''-mode ``bursts'' and ``quiet normal'' intervals alternate with each other quasi-periodically, making a cycle some 60--80 pulses in duration. ``Abnormal''-mode intervals are interspersed within this overall cycle, usually persisting for only a few pulses, but occasionally lasting for scores or even many hundreds of pulses. Within subsequences where the core is exceptionally quiet, the pulsar provides a nearly ``textbook'' example of a central PA sightline tr...

  4. Consequence analysis of core meltdown accidents in liquid metal fast reactor

    Suk, S.D.; Hahn, D. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)


    Core disruptive accidents have been investigated at Korea Atomic Energy Research Institute(KAERI) as part of work to demonstrate the inherent and ultimate safety of the conceptual design of the Korea Advanced Liquid Metal Reactor(KALIMER), a 150 Mw pool-type sodium cooled prototype fast reactor that uses U-Pu-Zr metallic fuel. In this study, a simple method was developed using a modified Bethe-Tait method to simulate the kinetics and hydraulic behavior of a homogeneous spherical core over the period of the super-prompt critical power excursion induced by the ramp reactivity insertion. Calculations of energy release during excursions in the sodium-voided core of the KALIMER were subsequently performed using the method for various reactivity insertion rates up to 100 $/s, which has been widely considered to be the upper limit of ramp rates due to fuel compaction. Benchmark calculations were made to compare with the results of more detailed analysis for core meltdown energetics of the oxide fuelled fast reactor. A set of parametric studies was also performed to investigate the sensitivity of the results on the various thermodynamics and reactor parameters. (author)

  5. Core-scale solute transport model selection using Monte Carlo analysis

    Malama, Bwalya; Kuhlman, Kristopher L.; James, Scott C.


    Model applicability to core-scale solute transport is evaluated using breakthrough data from column experiments conducted with conservative tracers tritium (3H) and sodium-22 (22Na ), and the retarding solute uranium-232 (232U). The three models considered are single-porosity, double-porosity with single-rate mobile-immobile mass-exchange, and the multirate model, which is a deterministic model that admits the statistics of a random mobile-immobile mass-exchange rate coefficient. The experiments were conducted on intact Culebra Dolomite core samples. Previously, data were analyzed using single-porosity and double-porosity models although the Culebra Dolomite is known to possess multiple types and scales of porosity, and to exhibit multirate mobile-immobile-domain mass transfer characteristics at field scale. The data are reanalyzed here and null-space Monte Carlo analysis is used to facilitate objective model selection. Prediction (or residual) bias is adopted as a measure of the model structural error. The analysis clearly shows single-porosity and double-porosity models are structurally deficient, yielding late-time residual bias that grows with time. On the other hand, the multirate model yields unbiased predictions consistent with the late-time -5/2 slope diagnostic of multirate mass transfer. The analysis indicates the multirate model is better suited to describing core-scale solute breakthrough in the Culebra Dolomite than the other two models.

  6. Coupled neutronic core and subchannel analysis of nanofluids in VVER-1000 type reactor

    Zarifi, Ehsan; Sepanloo, Kamran [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of). Reactor and Nuclear Safety School; Jahanfarnia, Golamreza [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Nuclear Engineering, Science and Research Branch


    This study is aimed to perform the coupled thermal-hydraulic/neutronic analysis of nanofluids as the coolant in the hot fuel assembly of VVER-1000 reactor core. Water-based nanofluid containing various volume fractions of Al{sub 2}O{sub 3} nanoparticle is analyzed. WIMS and CITATION codes are used for neutronic simulation of the reactor core, calculating neutron flux and thermal power distribution. In the thermal-hydraulic modeling, the porous media approach is used to analyze the thermal behavior of the reactor core and the subchannel analysis is used to calculate the hottest fuel assembly thermal-hydraulic parameters. The derived conservation equations for coolant and conduction heat transfer equation for fuel and clad are discretized by Finite volume method and solved numerically using visual FORTRAN program. Finally the analysis results for nanofluids and pure water are compared together. The achieved results show that at low concentration (0.1 percent volume fraction) alumina is the optimum nanoparticles for normal reactor operation.

  7. Glass Fibre-Reinforced Composite Post and Core Used in Decayed Primary Anterior Teeth: A Case Report

    Leena Verma


    Full Text Available Aesthetic requirement of severely mutilated primary anterior teeth in the case of early childhood caries has been a challenge to pediatric dentist. Among restorative treatment options, prefabricated crown and biological and resin composite restoration either by means of direct or indirect technique are mentioned in the literature. This paper presents the clinical sequence of rehabilitation of maxillary anterior primary teeth. Endodontic treatment was followed by the placement of a glass fibre-reinforced composite resin post. The crown reconstruction was done with composite restoration. Resin glass fibre post has best properties in elasticity, translucency, adaptability, tenaciousness, and resistance to traction and to impact. Along with ease of application, fiber can be used as an alternative to traditionally used materials in the management of early childhood caries.

  8. The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

    Riss Paul


    Full Text Available Abstract Background Limited data are available to evaluate the accuracy of frozen section analysis and ultrasound- guided core needle biopsy of the breast. Methods In a retrospective analysis data of 120 consecutive handheldultrasound- guided 14- gauge automated core needle biopsies (CNB in 109 consecutive patients with breast lesions between 2006 and 2007 were evaluated. Results In our outpatient clinic120 CNB were performed. In 59/120 (49.2% cases we compared histological diagnosis on frozen sections with those on paraffin sections of CNB and finally with the result of open biopsy. Of the cases 42/59 (71.2% were proved to be malignant and 17/59 (28.8% to be benign in the definitive histology. 2/59 (3.3% biopsies had a false negative frozen section result. No false positive results of the intraoperative frozen section analysis were obtained, resulting in a sensitivity, specificity and positive predicting value (PPV and negative predicting value (NPV of 95%, 100%, 100% and 90%, respectively. Histological and morphobiological parameters did not show up relevance for correct frozen section analysis. In cases of malignancy time between diagnosis and definitive treatment could not be reduced due to frozen section analysis. Conclusion The frozen section analysis of suspect breast lesions performed by CNB displays good sensitivity/specificity characteristics. Immediate investigations of CNB is an accurate diagnostic tool and an important step in reducing psychological strain by minimizing the period of uncertainty in patients with breast tumor.

  9. NODAL3 Sensitivity Analysis for NEACRP 3D LWR Core Transient Benchmark (PWR

    Surian Pinem


    Full Text Available This paper reports the results of sensitivity analysis of the multidimension, multigroup neutron diffusion NODAL3 code for the NEACRP 3D LWR core transient benchmarks (PWR. The code input parameters covered in the sensitivity analysis are the radial and axial node sizes (the number of radial node per fuel assembly and the number of axial layers, heat conduction node size in the fuel pellet and cladding, and the maximum time step. The output parameters considered in this analysis followed the above-mentioned core transient benchmarks, that is, power peak, time of power peak, power, averaged Doppler temperature, maximum fuel centerline temperature, and coolant outlet temperature at the end of simulation (5 s. The sensitivity analysis results showed that the radial node size and maximum time step give a significant effect on the transient parameters, especially the time of power peak, for the HZP and HFP conditions. The number of ring divisions for fuel pellet and cladding gives negligible effect on the transient solutions. For productive work of the PWR transient analysis, based on the present sensitivity analysis results, we recommend NODAL3 users to use 2×2 radial nodes per assembly, 1×18 axial layers per assembly, the maximum time step of 10 ms, and 9 and 1 ring divisions for fuel pellet and cladding, respectively.

  10. An approach to model reactor core nodalization for deterministic safety analysis

    Salim, Mohd Faiz; Samsudin, Mohd Rafie; Mamat @ Ibrahim, Mohd Rizal; Roslan, Ridha; Sadri, Abd Aziz; Farid, Mohd Fairus Abd


    Adopting good nodalization strategy is essential to produce an accurate and high quality input model for Deterministic Safety Analysis (DSA) using System Thermal-Hydraulic (SYS-TH) computer code. The purpose of such analysis is to demonstrate the compliance against regulatory requirements and to verify the behavior of the reactor during normal and accident conditions as it was originally designed. Numerous studies in the past have been devoted to the development of the nodalization strategy for small research reactor (e.g. 250kW) up to the bigger research reactor (e.g. 30MW). As such, this paper aims to discuss the state-of-arts thermal hydraulics channel to be employed in the nodalization for RTP-TRIGA Research Reactor specifically for the reactor core. At present, the required thermal-hydraulic parameters for reactor core, such as core geometrical data (length, coolant flow area, hydraulic diameters, and axial power profile) and material properties (including the UZrH1.6, stainless steel clad, graphite reflector) have been collected, analyzed and consolidated in the Reference Database of RTP using standardized methodology, mainly derived from the available technical documentations. Based on the available information in the database, assumptions made on the nodalization approach and calculations performed will be discussed and presented. The development and identification of the thermal hydraulics channel for the reactor core will be implemented during the SYS-TH calculation using RELAP5-3D® computer code. This activity presented in this paper is part of the development of overall nodalization description for RTP-TRIGA Research Reactor under the IAEA Norwegian Extra-Budgetary Programme (NOKEBP) mentoring project on Expertise Development through the Analysis of Reactor Thermal-Hydraulics for Malaysia, denoted as EARTH-M.

  11. An approach to model reactor core nodalization for deterministic safety analysis

    Salim, Mohd Faiz, E-mail:; Samsudin, Mohd Rafie, E-mail: [Nuclear Energy Department, Regulatory Economics & Planning Division, Tenaga Nasional Berhad (Malaysia); Mamat Ibrahim, Mohd Rizal, E-mail: [Prototypes & Plant Development Center, Malaysian Nuclear Agency (Malaysia); Roslan, Ridha, E-mail:; Sadri, Abd Aziz [Nuclear Installation Divisions, Atomic Energy Licensing Board (Malaysia); Farid, Mohd Fairus Abd [Reactor Technology Center, Malaysian Nuclear Agency (Malaysia)


    Adopting good nodalization strategy is essential to produce an accurate and high quality input model for Deterministic Safety Analysis (DSA) using System Thermal-Hydraulic (SYS-TH) computer code. The purpose of such analysis is to demonstrate the compliance against regulatory requirements and to verify the behavior of the reactor during normal and accident conditions as it was originally designed. Numerous studies in the past have been devoted to the development of the nodalization strategy for small research reactor (e.g. 250kW) up to the bigger research reactor (e.g. 30MW). As such, this paper aims to discuss the state-of-arts thermal hydraulics channel to be employed in the nodalization for RTP-TRIGA Research Reactor specifically for the reactor core. At present, the required thermal-hydraulic parameters for reactor core, such as core geometrical data (length, coolant flow area, hydraulic diameters, and axial power profile) and material properties (including the UZrH{sub 1.6}, stainless steel clad, graphite reflector) have been collected, analyzed and consolidated in the Reference Database of RTP using standardized methodology, mainly derived from the available technical documentations. Based on the available information in the database, assumptions made on the nodalization approach and calculations performed will be discussed and presented. The development and identification of the thermal hydraulics channel for the reactor core will be implemented during the SYS-TH calculation using RELAP5-3D{sup ®} computer code. This activity presented in this paper is part of the development of overall nodalization description for RTP-TRIGA Research Reactor under the IAEA Norwegian Extra-Budgetary Programme (NOKEBP) mentoring project on Expertise Development through the Analysis of Reactor Thermal-Hydraulics for Malaysia, denoted as EARTH-M.

  12. Spectral analysis of heart rate and blood pressure variability in primary Sjogren's syndrome

    P.J. Barendregt (Pieternella); J.H.M. Tulen (Joke); A.H. van den Meiracker (Anton); H.M. Markusse


    textabstractBACKGROUND: Autonomic dysfunction has been described in primary Sjogren's syndrome (SS). OBJECTIVE: To investigate the circulatory autonomic regulation in patients with primary SS by power spectral analysis of heart rate and blood pressure variability. METHODS: Forty th

  13. Spectral analysis of heart rate and blood pressure variability in primary Sjogren's syndrome

    P.J. Barendregt (Pieternella); J.H.M. Tulen (Joke); A.H. van den Meiracker (Anton); H.M. Markusse


    textabstractBACKGROUND: Autonomic dysfunction has been described in primary Sjogren's syndrome (SS). OBJECTIVE: To investigate the circulatory autonomic regulation in patients with primary SS by power spectral analysis of heart rate and blood pressure variability. METHODS: Forty th

  14. Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions

    Villegas Andre


    Full Text Available Abstract Background The pan-genome of a bacterial species consists of a core and an accessory gene pool. The accessory genome is thought to be an important source of genetic variability in bacterial populations and is gained through lateral gene transfer, allowing subpopulations of bacteria to better adapt to specific niches. Low-cost and high-throughput sequencing platforms have created an exponential increase in genome sequence data and an opportunity to study the pan-genomes of many bacterial species. In this study, we describe a new online pan-genome sequence analysis program, Panseq. Results Panseq was used to identify Escherichia coli O157:H7 and E. coli K-12 genomic islands. Within a population of 60 E. coli O157:H7 strains, the existence of 65 accessory genomic regions identified by Panseq analysis was confirmed by PCR. The accessory genome and binary presence/absence data, and core genome and single nucleotide polymorphisms (SNPs of six L. monocytogenes strains were extracted with Panseq and hierarchically clustered and visualized. The nucleotide core and binary accessory data were also used to construct maximum parsimony (MP trees, which were compared to the MP tree generated by multi-locus sequence typing (MLST. The topology of the accessory and core trees was identical but differed from the tree produced using seven MLST loci. The Loci Selector module found the most variable and discriminatory combinations of four loci within a 100 loci set among 10 strains in 1 s, compared to the 449 s required to exhaustively search for all possible combinations; it also found the most discriminatory 20 loci from a 96 loci E. coli O157:H7 SNP dataset. Conclusion Panseq determines the core and accessory regions among a collection of genomic sequences based on user-defined parameters. It readily extracts regions unique to a genome or group of genomes, identifies SNPs within shared core genomic regions, constructs files for use in phylogeny programs

  15. Faulting evidence of isostatic uplift in the Rincon Mountains metamorphic core complex: An image processing analysis

    Rodriguez-Guerra, Edna Patricia

    This study focuses on the applications of remote sensing techniques and digital analysis to characterizing of tectonic features of the Rincon Mountains metamorphic core complex. Data included Landsat Thematic Mapper (TM) images, digital elevation models (DEM), and digital orthophoto quadrangle quads (DOQQ). The main findings in this study are two nearly orthogonal systems of structures that have never been reported in the Rincon Mountains. The first system, a penetrative faulting system of the footwall rocks, trends N10--30°W. Similar structures identified in other metamorphic core complexes. The second system trends N60--70°E, and has only been alluded indirectly in the literature of metamorphic core complexes. The structures pervade mylonites in Tanque Verde Mountain, Mica Mountain, and the Rincon Peak area. As measured on the imagery, spacing between the N10--30°W lineaments ranges from ˜0.5 to 2 km, and from 0.25 to 1 km for the N60--70°E system. Field inspection reveals that the N10--30°W trending system, are high-angle normal faults dipping mainly to the west. One of the main faults, named here the Cabeza de Vaca fault, has a polished, planar, striated and grooved surface with slickenlines indicating pure normal dip-slip movement (N10°W, 83°SW; slickensides rake 85°SW). The Cabeza de Vaca fault is the eastern boundary of a 2 km-wide graben, with displacement as great as 400 meters. The N10--30°W faults are syn- to post-mylonitic, high-angle normal faults that formed during isostatic uplift of the Rincon core complex during mid-Tertiary time. This interpretation is based on previous works, which report similar fault patterns in other metamorphic core complexes. Faults trending N20--30°W, shape the east flank of Mica Mountain. These faults, on the back dipping mylonitic zone, dip east and may represent late-stage antithetic shear zones. The Cabeza de Vaca fault and the back dipping antithetic faults accommodate as much as 65% of the extension due to

  16. Subchannel analysis of a small ultra-long cycle fast reactor core

    Seo, Han; Kim, Ji Hyun; Bang, In Cheol, E-mail:


    Highlights: • The UCFR-100 is small-sized one of 60 years long-life nuclear reactors without refueling. • The design safety limits of the UCFR-100 are evaluated using MATRA-LMR. • The subchannel results are below the safety limits of general SFR design criteria. - Abstract: Thermal-hydraulic evaluation of a small ultra-long cycle fast reactor (UCFR) core is performed based on existing safety regulations. The UCFR is an innovative reactor newly designed with long-life core based on the breed-and-burn strategy and has a target electric power of 100 MWe (UCFR-100). Low enriched uranium (LEU) located at the bottom region of the core play the role of igniter to operate the UCFR for 60 years without refueling. A metallic form is selected as a burning fuel region material after the LEU location. HT-9 and sodium are used as cladding and coolant materials, respectively. In the present study, MATRA-LMR, subchannel analysis code, is used for evaluating the safety design limit of the UCFR-100 in terms of fuel, cladding, and coolant temperature distributions in the core as design criteria of a general fast reactor. The start-up period (0 year of operation), the middle of operating period (30 years of operation), and the end of operating cycle (60 years of operation) are analyzed and evaluated. The maximum cladding surface temperature (MCST) at the BOC (beginning of core life) is 498 °C on average and 551 °C when considering peaking factor, while the MCST at the MOC (middle of core life) is 498 °C on average and 548 °C in the hot channel, respectively, and the MCST at the EOC (end of core life) is 499 °C on average and 538 °C in the hot channel, respectively. The maximum cladding surface temperature over the long cycle is found at the BOC due to its high peaking factor. It is found that all results including fuel rods, cladding, and coolant exit temperature are below the safety limit of general SFR design criteria.

  17. Ultra-sensitive Flow Injection Analysis (FIA) determination of calcium in ice cores at ppt level.

    Traversi, R; Becagli, S; Castellano, E; Maggi, V; Morganti, A; Severi, M; Udisti, R


    A Flow Injection Analysis (FIA) spectrofluorimetric method for calcium determination in ice cores was optimised in order to achieve better analytical performances which would make it suitable for reliable calcium measurements at ppt level. The method here optimised is based on the formation of a fluorescent compound between Ca and Quin-2 in buffered environment. A careful evaluation of operative parameters (reagent concentration, buffer composition and concentration, pH), influence of interfering species possibly present in real samples and potential favourable effect of surfactant addition was carried out. The obtained detection limit is around 15 ppt, which is one order of magnitude lower than the most sensitive Flow Analysis method for Ca determination currently available in literature and reproducibility is better than 4% for Ca concentrations of 0.2 ppb. The method was validated through measurements performed in parallel with Ion Chromatography on 200 samples from an alpine ice core (Lys Glacier) revealing an excellent fit between the two chemical series. Calcium stratigraphy in Lys ice core was discussed in terms of seasonal pattern and occurrence of Saharan dust events.

  18. Analysis of three-dimensional thermo-hydraulic phenomena in the reactor core of LMFBR

    Hu, S.; Lee, Y. B.; Jang, W. P.; Ha, K. S.; Jung, H. Y. [KAERI, Taejon (Korea, Republic of)


    The mismatch between power and flow under the transient condition of LMFBR (Liquid Metal cooled Fast Breeder Reactor) core results in thermal stratification in hot pool. Since the fluid of hot pool enters IHXs, the temperature distribution of hot pool can alter the overall system response, therefore three-dimensional analysis of thermo-hydraulic phenomena is necessary. In this study, the thermo-hydraulic phenomena under normal operating condition and unprotected transient condition of LMFBR is investigated using which is the three-dimensional analysis code, COMMIX-1AR/P. The basic input data is based on the design data of KALIMER-600, which is sodium-cooled fast breeder reactor developed by KAERI. COMMIX-1AR/P code has not a reactivity model and the power and core flowrate must be supplied in the input data. In this study, results of SSC-K calculation is used. The temperature and velocity distributions are calculated and compared with those of SSC-K calculation results. The UTOF(Unprotected Loss Of Flow) accident is calculated using COMMIX-1AR/P and the temperature and velocity distributions in the total reactor core are calculated and the natural circulation mode under this transient condition is investigated.

  19. Contributed Review: Nuclear magnetic resonance core analysis at 0.3 T

    Mitchell, Jonathan, E-mail:; Fordham, Edmund J. [Schlumberger Gould Research, High Cross, Madingley Road, Cambridge CB3 0EL (United Kingdom)


    Nuclear magnetic resonance (NMR) provides a powerful toolbox for petrophysical characterization of reservoir core plugs and fluids in the laboratory. Previously, there has been considerable focus on low field magnet technology for well log calibration. Now there is renewed interest in the study of reservoir samples using stronger magnets to complement these standard NMR measurements. Here, the capabilities of an imaging magnet with a field strength of 0.3 T (corresponding to 12.9 MHz for proton) are reviewed in the context of reservoir core analysis. Quantitative estimates of porosity (saturation) and pore size distributions are obtained under favorable conditions (e.g., in carbonates), with the added advantage of multidimensional imaging, detection of lower gyromagnetic ratio nuclei, and short probe recovery times that make the system suitable for shale studies. Intermediate field instruments provide quantitative porosity maps of rock plugs that cannot be obtained using high field medical scanners due to the field-dependent susceptibility contrast in the porous medium. Example data are presented that highlight the potential applications of an intermediate field imaging instrument as a complement to low field instruments in core analysis and for materials science studies in general.

  20. Calculation and analysis of generator limiting regimes with respect to stator end core heating

    Kostić Miloje


    Full Text Available A new simplified procedure for defining the limiting operating regimes on the generator capability curve, with respect to stator end core heating, is proposed and described in this paper. First of all, a simplified analysis of axial flux leakage that penetrates into the end plates of the stator is carried out and the corresponding power losses are calculated. Then the analysis of measured point temperature increases over the stator end core, and a qualitative and quantitative overview of the effects, are presented. A simplified procedure for defining the limiting regime with regard to the heating stator end core, which is illustrated for the case of an operating diagram for a given generator of apparent power of 727 MVA (B2 is also described. The given limiting line constructed using this method is similar to the appropriate line constructed on the basis of complex and lengthy factory and on-site tests performed by the manufacturer and the user. According to the results and the check, the proposed method has been proved and the application of the simplified procedure can be recommended for use along with other procedures, at least when it comes to similar synchronous generators in Serbia's Electric Power Industry.

  1. Contributed review: nuclear magnetic resonance core analysis at 0.3 T.

    Mitchell, Jonathan; Fordham, Edmund J


    Nuclear magnetic resonance (NMR) provides a powerful toolbox for petrophysical characterization of reservoir core plugs and fluids in the laboratory. Previously, there has been considerable focus on low field magnet technology for well log calibration. Now there is renewed interest in the study of reservoir samples using stronger magnets to complement these standard NMR measurements. Here, the capabilities of an imaging magnet with a field strength of 0.3 T (corresponding to 12.9 MHz for proton) are reviewed in the context of reservoir core analysis. Quantitative estimates of porosity (saturation) and pore size distributions are obtained under favorable conditions (e.g., in carbonates), with the added advantage of multidimensional imaging, detection of lower gyromagnetic ratio nuclei, and short probe recovery times that make the system suitable for shale studies. Intermediate field instruments provide quantitative porosity maps of rock plugs that cannot be obtained using high field medical scanners due to the field-dependent susceptibility contrast in the porous medium. Example data are presented that highlight the potential applications of an intermediate field imaging instrument as a complement to low field instruments in core analysis and for materials science studies in general.

  2. Bacteriological analysis of necrotic pulp and fistulae in primary teeth

    FABRIS, Antônio Scalco; Nakano, Viviane; Avila-Campos,Mario Júlio


    Objectives: Primary teeth work as guides for the eruption of permanent dentition, contribute for the development of the jaws, chewing process, preparing food for digestion, and nutrient assimilation. Treatment of pulp necrosis in primary teeth is complex due to anatomical and physiological characteristics and high number of bacterial species present in endodontic infections. The bacterial presence alone or in association in necrotic pulp and fistula samples from primary teeth of boys and gir...

  3. Magnetic resonance imaging texture analysis classification of primary breast cancer

    Waugh, S.A.; Lerski, R.A. [Ninewells Hospital and Medical School, Department of Medical Physics, Dundee (United Kingdom); Purdie, C.A.; Jordan, L.B. [Ninewells Hospital and Medical School, Department of Pathology, Dundee (United Kingdom); Vinnicombe, S. [University of Dundee, Division of Imaging and Technology, Ninewells Hospital and Medical School, Dundee (United Kingdom); Martin, P. [Ninewells Hospital and Medical School, Department of Clinical Radiology, Dundee (United Kingdom); Thompson, A.M. [University of Texas MD Anderson Cancer Center, Department of Surgical Oncology, Houston, TX (United States)


    Patient-tailored treatments for breast cancer are based on histological and immunohistochemical (IHC) subtypes. Magnetic Resonance Imaging (MRI) texture analysis (TA) may be useful in non-invasive lesion subtype classification. Women with newly diagnosed primary breast cancer underwent pre-treatment dynamic contrast-enhanced breast MRI. TA was performed using co-occurrence matrix (COM) features, by creating a model on retrospective training data, then prospectively applying to a test set. Analyses were blinded to breast pathology. Subtype classifications were performed using a cross-validated k-nearest-neighbour (k = 3) technique, with accuracy relative to pathology assessed and receiver operator curve (AUROC) calculated. Mann-Whitney U and Kruskal-Wallis tests were used to assess raw entropy feature values. Histological subtype classifications were similar across training (n = 148 cancers) and test sets (n = 73 lesions) using all COM features (training: 75 %, AUROC = 0.816; test: 72.5 %, AUROC = 0.823). Entropy features were significantly different between lobular and ductal cancers (p < 0.001; Mann-Whitney U). IHC classifications using COM features were also similar for training and test data (training: 57.2 %, AUROC = 0.754; test: 57.0 %, AUROC = 0.750). Hormone receptor positive and negative cancers demonstrated significantly different entropy features. Entropy features alone were unable to create a robust classification model. Textural differences on contrast-enhanced MR images may reflect underlying lesion subtypes, which merits testing against treatment response. (orig.)

  4. Analysis of containment venting following a core damage at a BWR Mark I using THALES-2

    Widodo, Surip [Nuclear Safety Technology Development Center, National Nuclear Energy Agency (BATAN), Tangerang (Indonesia); Ishikawa, Jun; Muramatsu, Ken [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sakamoto, Toru [Toshiba Advanced System Co., Kawasaki, Kanagawa (Japan)


    Analysis of containment venting following a core damage at a boiling water reactor (BWR) Mark I using THALES-2 was performed. In this analysis, the effect of various parameters, namely, the areas of the vent path, containment venting pressure, and accident sequences on the containment thermodynamic response, and radionuclide transport and release in the containment venting at a BWR was examined. The code THALES-2B developed by the Japan Atomic Energy Research Institute (JAERI) was used in this analysis. The model plant in this analysis was the Browns Ferry plant. From this analysis was found that the 4-inch pipe of containment venting flow path is sufficient to maintain the containment pressure in the specified range if the containment was pressurized by the decay heat power. The entrainment by the pool swelling as well as by the flashing was not occurred during the containment venting. The source terms are not sensitive to the variation of containment venting flow path area. The containment venting pressure operation setting point has important rule in the containment venting. In the containment venting, the source terms are not sensitive to the accident sequence, except for Sr source term. In order to get better understanding on the containment venting strategy, the following analyses are necessary. Analyses of accident sequence which has a high power such as anticipated transient without scram are necessary, as well as analyses of accident sequence which pressurize the containment before the core damage. (author)

  5. Tank 241-AZ-102 Privatization Push Mode Core Sampling and Analysis Plan



    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AZ-102. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AZ-102. Push mode core samples will be obtained from risers 15C and 24A to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples, composite the liquids and solids, perform chemical analyses, and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AZ-102 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plan.

  6. Failure analysis of bolted joints in foam-core sandwich composites

    Zabihpoor, M.; Moslemian, Ramin; Afshin, M.


    This study represents an effort to predict the bearing strength, failure modes, and failure load of bolted joints in foam-core sandwich composites. The studied joints have been used in a light full composite airplane. By using solid laminates, a new design for the joint zone is developed....... These solid laminates include a number of glass plies with total thickness equal to core thickness. The effect of solid laminate size and interface angle of foam -solid laminate in the bonding zone on the bearing strength, failure loads and type of modes are investigated. The numerical study is performed...... using 3D FEM in ANSYS commercial code. Tsai-Wu failure criterion is used in the failure analysis. The results indicate that the most important parameter in the proposed joint zone design is the foam -solid laminate interface angle which plays an important role on the value of failure criterion (damage...

  7. Low time resolution analysis of polar ice cores cannot detect impulsive nitrate events

    Smart, D F; Melott, A L; Laird, C M


    Ice cores are archives of climate change and possibly large solar proton events (SPEs). Wolff et al. (2012) used a single event, a nitrate peak in the GISP2-H core, which McCracken et al. (2001a) time associated with the poorly quantified 1859 Carrington event, to discredit SPE-produced, impulsive nitrate deposition in polar ice. This is not the ideal test case. We critique the Wolff et al. analysis and demonstrate that the data they used cannot detect impulsive nitrate events because of resolution limitations. We suggest re-examination of the top of the Greenland ice sheet at key intervals over the last two millennia with attention to fine resolution and replicate sampling of multiple species. This will allow further insight into polar depositional processes on a sub-seasonal scale, including atmospheric sources, transport mechanisms to the ice sheet, post-depositional interactions, and a potential SPE association.

  8. Review of core disruptive accident analysis for liquid-metal cooled fast reactors

    Kim, Y. C.; Na, B. C.; Hahn, D. H


    Analysis methodologies of core disruptive accidents (CDAs) are reviewed. The role of CDAS in the overall safety evaluation of fast reactors has not always been well defined nor universally agreed upon. However, they have become a traditional issue in LMR safety, design, and licensing. The study is for the understanding of fast reactor behavior under CDA conditions to establish the consequences of such conditions and to provide a basis for evaluating consequence limiting design features for the KALIMER developments. The methods used to analyze CDAs from initiating event to complete core disruption are described. Two examples of CDA analyses for CRBRP and ALMR are given and R and D needed for better understanding of CDA phenomena are proposed. (author). 10 refs., 2 tabs., 3 figs

  9. CoreFlow: A computational platform for integration, analysis and modeling of complex biological data

    Pasculescu, Adrian; Schoof, Erwin; Creixell, Pau


    between data generation, analysis and manuscript writing. CoreFlow is being released to the scientific community as an open-sourced software package complete with proteomics-specific examples, which include corrections for incomplete isotopic labeling of peptides (SILAC) or arginine-to-proline conversion...... provides programmers with a framework to manage data in real-time. It allows users to upload data into a relational database (MySQL), and to create custom scripts in high-level languages such as R, Python, or Perl for processing, correcting and modeling this data. CoreFlow organizes these scripts...... into project-specific pipelines, tracks interdependencies between related tasks, and enables the generation of summary reports as well as publication-quality images. As a result, the gap between experimental and computational components of a typical large-scale biology project is reduced, decreasing the time...

  10. Analysis of ringing effects due to magnetic core materials in pulsed nuclear magnetic resonance circuits

    Prabhu Gaunkar, N., E-mail:; Bouda, N. R. Y.; Nlebedim, I. C.; Hadimani, R. L.; Mina, M.; Jiles, D. C. [Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011 (United States); Bulu, I.; Ganesan, K.; Song, Y. Q. [Schlumberger-Doll Research, Cambridge, Massachusetts 02139 (United States)


    This work presents investigations and detailed analysis of ringing in a non-resonant pulsed nuclear magnetic resonance (NMR) circuit. Ringing is a commonly observed phenomenon in high power switching circuits. The oscillations described as ringing impede measurements in pulsed NMR systems. It is therefore desirable that those oscillations decay fast. It is often assumed that one of the causes behind ringing is the role of the magnetic core used in the antenna (acting as an inductive load). We will demonstrate that an LRC subcircuit is also set-up due to the inductive load and needs to be considered due to its parasitic effects. It is observed that the parasitics associated with the inductive load become important at certain frequencies. The output response can be related to the response of an under-damped circuit and to the magnetic core material. This research work demonstrates and discusses ways of controlling ringing by considering interrelationships between different contributing factors.

  11. Unbalance Force Analysis of Primary Pump Shaft in PGSFR

    Kim, Sungkyun; Koo, Gyeonghoi [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    In this paper, rotor-dynamic characteristics for the primary pump shaft were obtained. On the basis of the results, we decided to almost double the shaft diameter. By virtue of this design change, the revised design can be satisfied with the critical speed design criteria as well as can decrease a number of support bearings. In the results of unbalance analysis, it was figured that the maximum bearing deflections and loads are within the design criteria. All rotating shafts, even in the absence of external loads, have always eccentric distance due to the manufacturing deviations, material defects, and installation error. This unbalance mass resulting in the eccentric distance of the rotating structure causes resonance at critical speeds. The resonance is the state at which the harmonic loads are excited at their natural frequencies causing shafts to vibrate excessively. This vibration of large amplitude causes shafts to bend and twists significantly and leads to permanent failure. Hence, the determination of these rotor-dynamic characteristics of rotating shaft in the mechanical design stage is much important. In this paper following issues are addressed: - Describe how to calculate the unbalance force. - Predict the natural frequency variations and identify critical speeds within or near the operating speed range of a shaft for consideration of the unbalance bearing stiffness and damping. - Determine the available support positions of a pump shaft to avoid resonance within operating speed. - Perform an unbalance response analysis of a shaft in order to calculate shaft displacement and quantify the forces acting on the shaft support that are caused due to shaft unbalance.

  12. Analysis and Design of Fully Integrated Planar Magnetics for Primary-Parallel Isolated Boost Converter

    Ouyang, Ziwei; Sen, Gökhan; Thomsen, Ole Cornelius;


    -I-E core geometry, reducing the total ferrite volume and core loss. The transformer windings are symmetrically distributed into the outer legs of E-cores and the inductor windings are wound on the center legs of E-cores with air gaps. Therefore, the inductor and the transformer can be operated...... and switching loss of MOSFETs are analyzed in-depth in this work as well. To verify the validity of the design approach, a 2-kW prototype converter with two primary power stages is implemented for a fuel cell fed traction applications with 20-50 V input and 400-V output. An efficiency of 95.9% can be achieved...

  13. Core-annular miscible two-fluid flow in a slippery pipe: A stability analysis

    Chattopadhyay, Geetanjali; Usha, Ranganathan; Sahu, Kirti Chandra


    This study is motivated by the preliminary direct numerical simulations in double-diffusive (DD) core-annular flows with slip at the wall which displayed elliptical shaped instability patterns as in a rigid pipe case; however, slip at the pipe wall delays the onset of instability for a range of parameters and increases the phase speed. This increased our curiosity to have a thorough understanding of the linear stability characteristics of the miscible DD two-fluid flow in a pipe with slip at the pipe wall. The present study, therefore, addresses the linear stability of viscosity-stratified core-annular Poiseuille flow of miscible fluids with matched density in a slippery pipe in the presence of two scalars diffusing at different rates. The physical mechanisms responsible for the occurrence of instabilities in the DD system are explained through an energy budget analysis. The differences and similarities between core-annular flow in a slippery pipe and in a plane channel with velocity slip at the walls are explored. The stability characteristics are significantly affected by the presence of slip. The diffusivity effect is non-monotonic in a DD system. A striking feature of instability is that only a band of wavenumbers is destabilized in the presence of moderate to large inertial effects. Both the longwave and shortwave are stabilized at small Reynolds numbers. Slip exhibits a dual role of stabilizing or destabilizing the flow. The preliminary direct numerical simulations confirm the predictions of the linear stability analysis. The present study reveals that it may be possible to control the instabilities in core-annular pressure driven pipe flows by imposing a velocity slip at the walls.

  14. Preliminary safety analysis for key design features of KALIMER with breakeven core

    Hahn, Do Hee; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, Y. B.; Jeong, K. S


    KAERI is currently developing the conceptual design of a Liquid Metal Reactor, KALIMER (Korea Advanced Liquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, descriptions of safety design features and safety analyses results for selected ATWS accidents for the breakeven core KALIMER are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the safety evaluation procedure for the KALIMER design is described in Chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events.In Chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram (ATWS) have been performed to investigate the KALIMER system response to the events. In Chapter 4, the design of the KALIMER containment dome and the results of its performance analyses are presented. The design of the existing containment and the KALIMER containment dome are compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core energetics behavior during HCDA in Chapter 5. Sensitivity analyses have been performed for the KALIMER core behavior during super-prompt critical excursions, using mathematical formulations developed in the framework of the Modified Bethe-Tait method. Work energy potential was then calculated based on the isentropic fuel expansion model.

  15. Improving performance portability for GPU-specific OpenCL kernels on multi-core/many-core CPUs by analysis-based transformations*#

    Mei WEN; Da-fei HUANG; Chang-qing XUN; Dong CHEN


    OpenCL is an open heterogeneous programming framework. Although OpenCL programs are func-tionally portable, they do not provide performance portability, so code transformation often plays an irreplaceable role. When adapting GPU-specifi c OpenCL kernels to run on multi-core/many-core CPUs, coarsening the thread granularity is necessary and thus has been extensively used. However, locality concerns exposed in GPU-specifi c OpenCL code are usually inherited without analysis, which may give side-effects on the CPU performance. Typi-cally, the use of OpenCL’s local memory on multi-core/many-core CPUs may lead to an opposite performance effect, because local-memory arrays no longer match well with the hardware and the associated synchronizations are costly. To solve this dilemma, we actively analyze the memory access patterns using array-access descriptors derived from GPU-specifi c kernels, which can thus be adapted for CPUs by (1) removing all the unwanted local-memory arrays together with the obsolete barrier statements and (2) optimizing the coalesced kernel code with vectorization and locality re-exploitation. Moreover, we have developed an automated tool chain that makes this transformation of GPU-specifi c OpenCL kernels into a CPU-friendly form, which is accompanied with a scheduler that forms a new OpenCL runtime. Experiments show that the automated transformation can improve OpenCL kernel performance on a multi-core CPU by an average factor of 3.24. Satisfactory performance improvements are also achieved on Intel’s many-integrated-core coprocessor. The resultant performance on both architectures is better than or comparable with the corresponding OpenMP performance.

  16. Analysis of primary cilia in directional cell migration in fibroblasts

    Christensen, Søren Tvorup; Veland, Iben; Schwab, Albrecht;


    Early studies of migrating fibroblasts showed that primary cilia orient in front of the nucleus and point toward the leading edge. Recent work has shown that primary cilia coordinate a series of signaling pathways critical to fibroblast cell migration during development and in wound healing. In p...

  17. Primary cardiac neoplasms:a clinicopathologic analysis of 81 cases



    Objective To study the disease spectrum,clinical and pathologic features of primary cardiac neoplasms at asingle medical in stitution during a period of eight years.Methods The clinical and pathologic features of 81 cases of primary cardiac neoplasms encountered at the Affiliated

  18. A finite element thermal analysis of various dowel and core materials

    Shanti Varghese


    Conclusion: Non-metallic dowel and core materials such as fibre reinforced composite dowels (FRC generate greater stress than metallic dowel and core materials. This emphasized the preferable use of the metallic dowel and core materials in the oral environment.

  19. The CERN antiproton target: hydrocode analysis of its core material dynamic response under proton beam impact

    Martin, Claudio Torregrosa; Calviani, Marco; Muñoz-Cobo, José-Luis


    Antiprotons are produced at CERN by colliding a 26 GeV/c proton beam with a fixed target made of a 3 mm diameter, 55 mm length iridium core. The inherent characteristics of antiproton production involve extremely high energy depositions inside the target when impacted by each primary proton beam, making it one of the most dynamically demanding among high energy solid targets in the world, with a rise temperature above 2000 {\\deg}C after each pulse impact and successive dynamic pressure waves of the order of GPa's. An optimized redesign of the current target is foreseen for the next 20 years of operation. As a first step in the design procedure, this numerical study delves into the fundamental phenomena present in the target material core under proton pulse impact and subsequent pressure wave propagation by the use of hydrocodes. Three major phenomena have been identified, (i) the dominance of a high frequency radial wave which produces destructive compressive-to-tensile pressure response (ii) The existence of...

  20. CERN antiproton target: Hydrocode analysis of its core material dynamic response under proton beam impact

    Martin, Claudio Torregrosa; Perillo-Marcone, Antonio; Calviani, Marco; Muñoz-Cobo, José-Luis


    Antiprotons are produced at CERN by colliding a 26 GeV /c proton beam with a fixed target made of a 3 mm diameter, 55 mm length iridium core. The inherent characteristics of antiproton production involve extremely high energy depositions inside the target when impacted by each primary proton beam, making it one of the most dynamically demanding among high energy solid targets in the world, with a rise temperature above 2000 °C after each pulse impact and successive dynamic pressure waves of the order of GPa's. An optimized redesign of the current target is foreseen for the next 20 years of operation. As a first step in the design procedure, this numerical study delves into the fundamental phenomena present in the target material core under proton pulse impact and subsequent pressure wave propagation by the use of hydrocodes. Three major phenomena have been identified, (i) the dominance of a high frequency radial wave which produces destructive compressive-to-tensile pressure response (ii) The existence of end-of-pulse tensile waves and its relevance on the overall response (iii) A reduction of 44% in tensile pressure could be obtained by the use of a high density tantalum cladding.

  1. Phylogenetic analysis of anaerobic psychrophilic enrichment cultures obtained from a greenland glacier ice core

    Sheridan, Peter P.; Miteva, Vanya I.; Brenchley, Jean E.


    The examination of microorganisms in glacial ice cores allows the phylogenetic relationships of organisms frozen for thousands of years to be compared with those of current isolates. We developed a method for aseptically sampling a sediment-containing portion of a Greenland ice core that had remained at -9 degrees C for over 100,000 years. Epifluorescence microscopy and flow cytometry results showed that the ice sample contained over 6 x 10(7) cells/ml. Anaerobic enrichment cultures inoculated with melted ice were grown and maintained at -2 degrees C. Genomic DNA extracted from these enrichments was used for the PCR amplification of 16S rRNA genes with bacterial and archaeal primers and the preparation of clone libraries. Approximately 60 bacterial inserts were screened by restriction endonuclease analysis and grouped into 27 unique restriction fragment length polymorphism types, and 24 representative sequences were compared phylogenetically. Diverse sequences representing major phylogenetic groups including alpha, beta, and gamma Proteobacteria as well as relatives of the Thermus, Bacteroides, Eubacterium, and Clostridium groups were found. Sixteen clone sequences were closely related to those from known organisms, with four possibly representing new species. Seven sequences may reflect new genera and were most closely related to sequences obtained only by PCR amplification. One sequence was over 12% distant from its closest relative and may represent a novel order or family. These results show that phylogenetically diverse microorganisms have remained viable within the Greenland ice core for at least 100,000 years.

  2. Continuous flow analysis of total organic carbon in polar ice cores.

    Federer, Urs; Kaufmann, Patrik R; Hutterli, Manuel A; Schüpbach, Simon; Stocker, Thomas F


    Ice cores are a widely used archive to reconstruct past changes of the climate system. This is done by measuring the concentration of substances in the ice and in the air of bubbles enclosed in ice. Some species pertaining to the carbon cycle (e.g., CO2, CH4) are routinely measured. However, information about the organic fraction of the impurities in polar ice is still very limited. Therefore, we developed a new method to determine the content of total organic carbon (TOC) in ice cores using a continuous flow analysis (CFA) system. The method is based on photochemical oxidation of TOC and the electrolytic quantification of the CO2 produced during oxidation. The TOC instrument features a limit of detection of 2 ppbC and a response time of 60 s at a sample flow rate of 0.7 mL/min and a linear measurement range of 2-4000 ppbC. First measurements on the ice core from Talos Dome, Antarctica, reveal TOC concentrations varying between 80 and 360 ppbC in the 20 m section presented.

  3. TRAC analysis of upper plenum thermal-hydraulic phenomena in the slab core test facility

    Shire, P.; Boyack, B.


    The Transient Reactor Analysis Code, TRAC-PF1/MOD1, was used to analyze an upper-plenum model of the Slab Core Test Facility (SCTF). The SCTF is a two-dimensional thermal-hydraulic model of a pressurized water reactor used for core-reflood simulations by the Japan Atomic Energy Research Institute. The purpose of this study was to evaluate the effects of code input-model refinements on the comparison between TRAC calculations and test data. Of particular interest were the comparisons of upper-plenum liquid levels and of the distributions of liquid radially across the upper-plenum. The upper-plenum region was selected for study. The test data indicated that the liquid level responded to the onset of emergency core cooling (ECC) by rising in the upper-plenum immediately when injection occurred. However, the early TRAC results indicated no significant liquid level increase until approx.300 s after the injection. Test data also indicated a liquid gradient rising toward the hot-leg entrance, but none was observed with TRAC.

  4. Analysis of Fracture in Cores from the Tuff Confining Unit beneath Yucca Flat, Nevada Test Site

    Lance Prothro


    The role fractures play in the movement of groundwater through zeolitic tuffs that form the tuff confining unit (TCU) beneath Yucca Flat, Nevada Test Site, is poorly known. This is an important uncertainty, because beneath most of Yucca Flat the TCU lies between the sources of radionuclide contaminants produced by historic underground nuclear testing and the regional carbonate aquifer. To gain a better understanding of the role fractures play in the movement of groundwater and radionuclides through the TCU beneath Yucca Flat, a fracture analysis focusing on hydraulic properties was performed on conventional cores from four vertical exploratory holes in Area 7 of Yucca Flat that fully penetrate the TCU. The results of this study indicate that the TCU is poorly fractured. Fracture density for all fractures is 0.27 fractures per vertical meter of core. For open fractures, or those observed to have some aperture, the density is only 0.06 fractures per vertical meter of core. Open fractures are characterized by apertures ranging from 0.1 to 10 millimeter, and averaging 1.1 millimeter. Aperture typically occurs as small isolated openings along the fracture, accounting for only 10 percent of the fracture volume, the rest being completely healed by secondary minerals. Zeolite is the most common secondary mineral occurring in 48 percent of the fractures observed.

  5. Primary health care research in Bolivia: systematic review and analysis.

    Alvarez, Francisco N; Leys, Mart; Mérida, Hugo E Rivera; Guzmán, Giovanni Escalante


    Bolivia is currently undergoing a series of healthcare reforms centred around the Unified Family, Community and Intercultural Health System (SAFCI), established in 2008 and Law 475 for Provision of Comprehensive Health Services enacted in 2014 as a first step towards universal health coverage. The SAFCI model aims to establish an intercultural, intersectoral and integrated primary health care (PHC) system, but there has not been a comprehensive analysis of effective strategies towards such an end. In this systematic review, we analyse research into developing PHC in Bolivia utilizing MEDLINE, the Virtual Health Library and grey literature from Pan American Health Organization/World Health Organization's internal database. We find that although progress has been made towards implementation of a healthcare system incorporating principles of PHC, further refining the system and targeting improvements effectively will require increased research and evaluation. Particularly in the 7 years since establishment of SAFCI, there has been a dearth of PHC research that makes evaluation of such key national policies impossible. The quantity and quality of PHC research must be improved, especially quasi-experimental studies with adequate control groups. The infrastructure for such studies must be strengthened through improved financing mechanisms, expanded institutional capacity and setting national research priorities. Important for future progress are improved tracking of health indicators, which in Bolivia are often out-of-date or incomplete, and prioritization of focused national research priorities on relevant policy issues. This study aims to serve as an aid towards PHC development efforts at the national level, as well as provide lessons for countries globally attempting to build effective health systems accommodating of a multi-national population in the midst of development.

  6. Primary metabolism in Lactobacillus sakei food isolates by proteomic analysis

    Champomier-Vergès Marie-Christine


    Full Text Available Abstract Background Lactobacillus sakei is an important food-associated lactic acid bacterium commonly used as starter culture for industrial meat fermentation, and with great potential as a biopreservative in meat and fish products. Understanding the metabolic mechanisms underlying the growth performance of a strain to be used for food fermentations is important for obtaining high-quality and safe products. Proteomic analysis was used to study the primary metabolism in ten food isolates after growth on glucose and ribose, the main sugars available for L. sakei in meat and fish. Results Proteins, the expression of which varied depending on the carbon source were identified, such as a ribokinase and a D-ribose pyranase directly involved in ribose catabolism, and enzymes involved in the phosphoketolase and glycolytic pathways. Expression of enzymes involved in pyruvate and glycerol/glycerolipid metabolism were also affected by the change of carbon source. Interestingly, a commercial starter culture and a protective culture strain down-regulated the glycolytic pathway more efficiently than the rest of the strains when grown on ribose. The overall two-dimensional gel electrophoresis (2-DE protein expression pattern was similar for the different strains, though distinct differences were seen between the two subspecies (sakei and carnosus, and a variation of about 20% in the number of spots in the 2-DE gels was observed between strains. A strain isolated from fermented fish showed a higher expression of stress related proteins growing on both carbon sources. Conclusions It is obvious from the data obtained in this study that the proteomic approach efficiently identifies differentially expressed proteins caused by the change of carbon source. Despite the basic similarity in the strains metabolic routes when they ferment glucose and ribose, there were also interesting differences. From the application point of view, an understanding of regulatory

  7. Primary structural analysis of sulfhydryl protease inhibitors from pineapple stem.

    Reddy, M N; Keim, P S; Heinrikson, R L; Kezdy, F J


    Pineapple stem acetone powder provides a rich source of the sulfhydryl protease bromelain and of a family of compositionally similar but chromatographically distinct polypeptide inihibtors of this enzyme. The isoinhibitors have molecular weights of 5600, and they contain five disulfide bonds and about 50 amino acids each (Perlstein, S. H., AND Kezdy, F.J. (1973) J. Supramol. Struct. 1, 249-254). Primary structural analysis of one of the seven inhibitor fractions (VII) revealed extensive microheterogeneity. Each of the inhibitor molecules in Fraction VII was shown to be composed of two peptide chains joined by disulfide bonds. These chains, designated A and B on the basis of size, comprise 41 and 10-11 residues, respectively, and the amino acid sequence of one of each are given below: (see article for formular). On the basis of ionization properties and yields of the A and B chains, it would appear that one of the major inhibitor species in Fraction VII is the covalently linked complex of the two chains shown, namely [A-1, B-2]. The second major inhibitor component of Fraction VII is identical in structure with [A-1, B-2i1 except that residues 1 and 8 in the A chain are pyroglutamate and threonine, respectively, and in the B chain glutamine 11 is replaced by arginine. The third inhibitor in Fraction VII is a minor constituent identical with the second, except that residue 1 in the A chain is glutamate rather than pyroglutamate. This microheterogeneity in the inhibitors of Fraction VII is further increased by the fact that B chains may lack threonine 1, in which case they are decapeptides beginning with alanine. On the basis of the striking homology of the cysteine residues with those of other protease inhibitors, it is proposed that the bromelain inhibitors are generated enzymatically from single chain precursors by excision of a "bridge" paptide which links the NH-2 termal A chain to the COOH-terminal B chain.

  8. Development of core design/analysis technology for integral reactor; verification of SMART nuclear design by Monte Carlo method

    Kim, Chang Hyo; Hong, In Seob; Han, Beom Seok; Jeong, Jong Seong [Seoul National University, Seoul (Korea)


    The objective of this project is to verify neutronics characteristics of the SMART core design as to compare computational results of the MCNAP code with those of the MASTER code. To achieve this goal, we will analyze neutronics characteristics of the SMART core using the MCNAP code and compare these results with results of the MASTER code. We improved parallel computing module and developed error analysis module of the MCNAP code. We analyzed mechanism of the error propagation through depletion computation and developed a calculation module for quantifying these errors. We performed depletion analysis for fuel pins and assemblies of the SMART core. We modeled a 3-D structure of the SMART core and considered a variation of material compositions by control rods operation and performed depletion analysis for the SMART core. We computed control-rod worths of assemblies and a reactor core for operation of individual control-rod groups. We computed core reactivity coefficients-MTC, FTC and compared these results with computational results of the MASTER code. To verify error analysis module of the MCNAP code, we analyzed error propagation through depletion of the SMART B-type assembly. 18 refs., 102 figs., 36 tabs. (Author)

  9. BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis, Version III

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W. III.


    This report is a condensed documentation for VERSION III of the BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis. An experienced analyst should be able to use this system routinely for solving problems by referring to this document. Individual reports must be referenced for details. This report covers basic input instructions and describes recent extensions to the modules as well as to the interface data file specifications. Some application considerations are discussed and an elaborate sample problem is used as an instruction aid. Instructions for creating the system on IBM computers are also given.

  10. Investigating the Use of 3-D Deterministic Transport for Core Safety Analysis

    H. D. Gougar; D. Scott


    An LDRD (Laboratory Directed Research and Development) project is underway at the Idaho National Laboratory (INL) to demonstrate the feasibility of using a three-dimensional multi-group deterministic neutron transport code (Attila®) to perform global (core-wide) criticality, flux and depletion calculations for safety analysis of the Advanced Test Reactor (ATR). This paper discusses the ATR, model development, capabilities of Attila, generation of the cross-section libraries, comparisons to experimental results for Advanced Fuel Cycle (AFC) concepts, and future work planned with Attila.

  11. Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE

    Valen, Eivind; Pascarella, Giovanni; Chalk, Alistair;


    in a given tissue. Here, we present a new method for high-throughput sequencing of 5' cDNA tags-DeepCAGE: merging the Cap Analysis of Gene Expression method with ultra-high-throughput sequence technology. We apply DeepCAGE to characterize 1.4 million sequenced TSS from mouse hippocampus and reveal a wealth...... of novel core promoters that are preferentially used in hippocampus: This is the most comprehensive promoter data set for any tissue to date. Using these data, we present evidence indicating a key role for the Arnt2 transcription factor in hippocampus gene regulation. DeepCAGE can also detect promoters...

  12. Simultaneous stable isotope analysis of methane and nitrous oxide on ice core samples

    C. J. Sapart


    Full Text Available Methane and nitrous oxide are important greenhouse gases which show a strong increase in atmospheric mixing ratios since pre-industrial time as well as large variations during past climate changes. The understanding of their biogeochemical cycles can be improved using stable isotope analysis. However, high-precision isotope measurements on air trapped in ice cores are challenging because of the high susceptibility to contamination and fractionation.

    Here, we present a dry extraction system for combined CH4 and N2O stable isotope analysis from ice core air, using an ice grating device. The system allows simultaneous analysis of δD(CH4 or δ13C(CH4, together with δ15N(N2O, δ18O(N2O and δ15N(NO+ fragment on a single ice core sample, using two isotope mass spectrometry systems. The optimum quantity of ice for analysis is about 600 g with typical "Holocene" mixing ratios for CH4 and N2O. In this case, the reproducibility (1σ is 2.1‰ for δD(CH4, 0.18‰ for δ13C(CH4, 0.51‰ for δ15N(N2O, 0.69‰ for δ18O(N2O and 1.12‰ for δ15N(NO+ fragment. For smaller amounts of ice the standard deviation increases, particularly for N2O isotopologues. For both gases, small-scale intercalibrations using air and/or ice samples have been carried out in collaboration with other institutes that are currently involved in isotope measurements of ice core air. Significant differences are shown between the calibration scales, but those offsets are consistent and can therefore be corrected for.

  13. Compression After Impact Experiments and Analysis on Honeycomb Core Sandwich Panels with Thin Facesheets

    McQuigg, Thomas D.


    A better understanding of the effect of impact damage on composite structures is necessary to give the engineer an ability to design safe, efficient structures. Current composite structures suffer severe strength reduction under compressive loading conditions, due to even light damage, such as from low velocity impact. A review is undertaken to access the current state-of-development in the areas of experimental testing, and analysis methods. A set of experiments on honeycomb core sandwich panels, with thin woven fiberglass cloth facesheets, is described, which includes detailed instrumentation and unique observation techniques.

  14. Analysis of core damage frequency: Peach Bottom, Unit 2 internal events appendices

    Kolaczkowski, A.M.; Cramond, W.R.; Sype, T.T.; Maloney, K.J.; Wheeler, T.A.; Daniel, S.L. (Science Applications International Corp., Albuquerque, NM (USA); Sandia National Labs., Albuquerque, NM (USA))


    This document contains the appendices for the accident sequence analysis of internally initiated events for the Peach Bottom, Unit 2 Nuclear Power Plant. This is one of the five plant analyses conducted as part of the NUREG-1150 effort for the Nuclear Regulatory Commission. The work performed and described here is an extensive reanalysis of that published in October 1986 as NUREG/CR-4550, Volume 4. It addresses comments from numerous reviewers and significant changes to the plant systems and procedures made since the first report. The uncertainty analysis and presentation of results are also much improved, and considerable effort was expended on an improved analysis of loss of offsite power. The content and detail of this report is directed toward PRA practitioners who need to know how the work was done and the details for use in further studies. The mean core damage frequency is 4.5E-6 with 5% and 95% uncertainty bounds of 3.5E-7 and 1.3E-5, respectively. Station blackout type accidents (loss of all ac power) contributed about 46% of the core damage frequency with Anticipated Transient Without Scram (ATWS) accidents contributing another 42%. The numerical results are driven by loss of offsite power, transients with the power conversion system initially available operator errors, and mechanical failure to scram. 13 refs., 345 figs., 171 tabs.

  15. Fluid-structure interaction analysis of a hypothetical core disruptive accident in LMFBRs

    Liu Chuang [Department of Engineering Mechanics, Tsinghua University, Beijing 100084 (China)]. E-mail:; Zhang Xiong [Department of Engineering Mechanics, Tsinghua University, Beijing 100084 (China); Lu Mingwan [Department of Engineering Mechanics, Tsinghua University, Beijing 100084 (China)


    To ensure safety, it is necessary to assess the integrity of a reactor vessel of liquid-metal fast breeder reactor (LMFBR) under HCDA. Several important problems for a fluid-structural interaction analysis of HCDA are discussed in the present paper. Various loading models of hypothetical core disruptive accident (HCDA) are compared and the polytropic processes of idea gas (PPIG) law is recommended. In order to define a limited total energy release, a '5% truncation criterion' is suggested. The relationship of initial pressure of gas bubble and the total energy release is given. To track the moving interfaces and to avoid the severe mesh distortion an arbitrary Lagrangrian-Eulerian (ALE) approach is adopted in the finite element modeling (FEM) analysis. Liquid separation and splash from a free surface are discussed. By using an elasticity solution under locally uniform pressure, two simplified analytical solutions for 3D and axi-symmetric case of the liquid impact pressure on roof slab are derived. An axi-symmetric finite elements code FRHCDA for fluid-structure interaction analysis of hypothetical core disruptive accident in LMFBR is developed. The CONT benchmark problem is calculated. The numerical results agree well with those from published papers.

  16. Analysis of Postulated Core Meltdown of an SRP Reactor - Final Report

    Durant, W.S.; Brown, R.J.


    An analysis was made to determine the consequences of a postulated accident in which the core of a Savannah River Plant reactor melts down following the loss of coolant. The study was made to determine (1) the potential damage to the reactor building that could impair its integrity for confining activity and (2) the need for additional facilities to prevent the activity confinement system from being overheated by the decay heat in the debris. A preliminary report on this analysis was issued previously. The sequence of events during and following the loss of coolant has now been studied in more detail, and a computer program has been written and used to investigate transient heating effects. This is the final report of the analysis and presents the conclusions.

  17. Reliable Quantitative SERS Analysis Facilitated by Core-Shell Nanoparticles with Embedded Internal Standards.

    Shen, Wei; Lin, Xuan; Jiang, Chaoyang; Li, Chaoyu; Lin, Haixin; Huang, Jingtao; Wang, Shuo; Liu, Guokun; Yan, Xiaomei; Zhong, Qiling; Ren, Bin


    Quantitative analysis is a great challenge in surface-enhanced Raman scattering (SERS). Core-molecule-shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods.

  18. Feasibility analysis of real-time physical modeling using WaveCore processor technology on FPGA

    Verstraelen, Math; Pfeifle, Florian; Bader, Rolf


    WaveCore is a scalable many-core processor technology. This technology is specifically developed and optimized for real-time acoustical modeling applications. The programmable WaveCore soft-core processor is silicon-technology independent and hence can be targeted to ASIC or FPGA technologies. The W

  19. Impact analysis of different operation strategies for battery energy storage systems (BESS) providing primary control reserve

    Fleer, Johannes; Stenzel, Peter; Linssen, Jochen


    In this work, a techno-economic analysis of stationary battery systems providing primary control for grid stabilisation is conducted. The effects of battery design and operation strategies adapted for primary control supply are investigated with regard to costs and parameters relevant for battery aging. Primary control is required to balance the feed-in and use of electricity to/from the grid, thereby ensuring safe and stable grid operation. In Germany, primary control is traded on a separate...

  20. Quantifying the Impact of Nanoparticle Coatings and Non-uniformities on XPS Analysis: Gold/silver Core-shell Nanoparticles

    Wang, Yung-Chen Andrew; Engelhard, Mark H.; Baer, Donald R.; Castner, David G.


    Abstract or short description: Spectral modeling of photoelectrons can serve as a valuable tool when combined with X-ray photoelectron spectroscopy (XPS) analysis. Herein, a new version of the NIST Simulation of Electron Spectra for Surface Analysis (SESSA 2.0) software, capable of directly simulating spherical multilayer NPs, was applied to model citrate stabilized Au/Ag-core/shell nanoparticles (NPs). The NPs were characterized using XPS and scanning transmission electron microscopy (STEM) to determine the composition and morphology of the NPs. The Au/Ag-core/shell NPs were observed to be polydispersed in size, non-circular, and contain off-centered Au-cores. Using the average NP dimensions determined from STEM analysis, SESSA spectral modeling indicated that washed Au/Ag-core shell NPs were stabilized with a 0.8 nm l

  1. Business Process Modelling is an Essential Part of a Requirements Analysis. Contribution of EFMI Primary Care Working Group.

    de Lusignan, S; Krause, P; Michalakidis, G; Vicente, M Tristan; Thompson, S; McGilchrist, M; Sullivan, F; van Royen, P; Agreus, L; Desombre, T; Taweel, A; Delaney, B


    To perform a requirements analysis of the barriers to conducting research linking of primary care, genetic and cancer data. We extended our initial data-centric approach to include socio-cultural and business requirements. We created reference models of core data requirements common to most studies using unified modelling language (UML), dataflow diagrams (DFD) and business process modelling notation (BPMN). We conducted a stakeholder analysis and constructed DFD and UML diagrams for use cases based on simulated research studies. We used research output as a sensitivity analysis. Differences between the reference model and use cases identified study specific data requirements. The stakeholder analysis identified: tensions, changes in specification, some indifference from data providers and enthusiastic informaticians urging inclusion of socio-cultural context. We identified requirements to collect information at three levels: micro- data items, which need to be semantically interoperable, meso- the medical record and data extraction, and macro- the health system and socio-cultural issues. BPMN clarified complex business requirements among data providers and vendors; and additional geographical requirements for patients to be represented in both linked datasets. High quality research output was the norm for most repositories. Reference models provide high-level schemata of the core data requirements. However, business requirements' modelling identifies stakeholder issues and identifies what needs to be addressed to enable participation.

  2. Power Production Analysis of the OE Buoy WEC for the CORES Project

    Lavelle, John; Kofoed, Jens Peter

    This report describes the analysis performed on the OE Buoy for the CORES project by the wave energy group at Aalborg University, Denmark. OE Buoy is a type of Oscillating Water Column (OWC) wave energy converter as part of the CORES project. This type of device is one of the most developed to ex...... meant that it was not possible to fully implement the method, as the efficiency data was too sparsely distributed as a function of Tz and Hs, but the method used here is based on the Equimar protocol to give an approximate estimate of the yearly power production....... which a total of 39 hours of power production data was collected. A data acquisition system was used to sample the sensors on board and the generator shaft power time-series data was used in the analysis here. A wave-rider buoy, located at the site of OE Buoy and operated by the Marine Institute Ireland....... This may then be used to estimate the yearly power production of the device at the test site location or another location, by using the long-term wave statistics for the given site. Additionally, the power production for a given scale of device may be estimated by applying the appropriate scaling...

  3. Partial Safety Analysis for a Reduced Uranium Enrichment Core for the High Flux Isotope Reactor

    Primm, Trent [ORNL; Gehin, Jess C [ORNL


    A computational model of the reactor core of the High Flux Isotope Rector (HFIR) was developed in order to analyze non-destructive accidents caused by transients during reactor operation. The reactor model was built for the latest version of the nuclear analysis software package called Program for the Analysis of Reactor Transients (PARET). Analyses performed with the model constructed were compared with previous data obtained with other tools in order to benchmark the code. Finally, the model was used to analyze the behavior of the reactor under transients using a different nuclear fuel with lower enrichment of uranium (LEU) than the fuel currently used, which has a high enrichment of uranium (HEU). The study shows that the presence of fertile isotopes in LEU fuel, which increases the neutron resonance absorption, reduces the impact of transients on the fuel and enhances the negative reactivity feedback, thus, within the limitations of this study, making LEU fuel appear to be a safe alternative fuel for the reactor core.


    B. Boer; A. M. Ougouag


    Achieving a high burnup in the Deep-Burn pebble bed reactor design, while remaining within the limits for fuel temperature, power peaking and temperature reactivity feedback, is challenging. The high content of Pu and Minor Actinides in the Deep-Burn fuel significantly impacts the thermal neutron energy spectrum. This can result in power and temperature peaking in the pebble bed core in locally thermalized regions near the graphite reflectors. Furthermore, the interplay of the Pu resonances of the neutron absorption cross sections at low-lying energies can lead to a positive temperature reactivity coefficient for the graphite moderator at certain operating conditions. To investigate the aforementioned effects a code system using existing codes has been developed for neutronic, thermal-hydraulic and fuel depletion analysis of Deep-Burn pebble bed reactors. A core analysis of a Deep-Burn Pebble Bed Modular Reactor (400 MWth) design has been performed for two Deep-Burn fuel types and possible improvements of the design with regard to power peaking and temperature reactivity feedback are identified.

  5. Getting to the core of protein pharmaceuticals – comprehensive structure analysis by mass spectrometry

    Leurs, Ulrike; Mistarz, Ulrik Hvid; Rand, Kasper Dyrberg


    Protein pharmaceuticals are the fastest growing class of novel therapeutic agents, and have been a major research and development focus in the (bio)pharmaceutical industry. Due to their large size and structural diversity, biopharmaceuticals represent a formidable challenge regarding analysis....... Mass spectrometry has evolved as a powerful tool for the characterization of both primary and higher order structures of protein pharmaceuticals. Furthermore, the chemical and physical stability of protein drugs, as well as their pharmacokinetics are nowadays routinely determined by mass spectrometry...

  6. Design and Analysis of an Efficient Primary Synchronization Signal Detector



    Full Text Available In this paper, we present a novel design for the detection of primary synchronization signal in a Long Term Evolution (LTE system based device at the expense of low cost and low power. This is facilitated by using a matched filter architecture which incorporates parallel processing. The approach of a 1-bit analog-todigital converter (ADC with down-sampling is compared with that of a 10-bit ADC without down-sampling under multi-path fading conditions defined in LTE standard for user equipment (UE performance test. A high performance primary synchronization signal detection method is derived in this paper.


    Tukiran Surbakti


    Full Text Available Abstract NEUTRONICS ANALYSIS ON MINI TEST FUEL IN THE RSG-GAS CORE. Research of UMo fuel for research reactor has been developing  right now. The fuel of  research reactor used is uranium low enrichment with high density. For supporting the development of fuel, an assessment of mini fuel in the RSG-GAS core was performed. The mini fuel are U7Mo-Al and U6Zr-Al with densitis of 7.0gU/cc and 5.2 gU/cc, respectively. The size of both fuel are the same namely 630x70.75x1.30 mm were inserted to the 3 plates of dummy fuel. Before being irradiated in the core, a calculation for safety analysis  from neutronics and thermohydrolics aspects were required. However, in this paper will discuss safety analysis of the U7Mo-Al and U6Zr-Al mini fuels from neutronic point of view.  The calculation was done using WIMSD-5B and Batan-3DIFF code. The result showed that both of the mini fuels could be irradiated in the RSG-GAS core with burn up less than 70 % within 12 cycles of operation without over limiting the safety margin. Power density of U7Mo-Al mini fuel bigger than U6Zr-Al fuel.   Key words: mini fuel, neutronics analysis, reactor core, safety analysis   Abstrak ANALISIS NEUTRONIK ELEMEN BAKAR UJI MINI DI TERAS RSG-GAS. Penelitian tentang bahan bakar UMo untuk reaktor riset terus berkembang saat ini. Bahan bakar reaktor riset yang digunakan adalah uranium pengkayaan rendah namun densitas tinggi.  Untuk mendukung pengembangan bahan bakar dilakukan uji elemen bakar mini di teras reakror RSG-GAS dengan tujuan menentukan jumlah siklus di dalam teras sehingga tercapai fraksi bakar maksimum. Bahan bakar yang diuji adalah U7Mo-Al dengan densitas 7,0 gU/cc dan U6Zr-Al densitas 5,2 gU/cc. Ukuran kedua bahan bakar uji tersebut adalah sama 630x70,75x1,30 mm dimasukkan masing masing kedalam 3 pelat dummy bahan bakar. Sebelum diiradiasi ke dalam teras reaktor maka perlu dilakukan perhitungan keselamatan baik secara neutronik maupun termohidrolik. Dalam makalah ini

  8. Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets.

    Hassan, Afreenish; Naz, Anam; Obaid, Ayesha; Paracha, Rehan Zafar; Naz, Kanwal; Awan, Faryal Mehwish; Muhmmad, Syed Aun; Janjua, Hussnain Ahmed; Ahmad, Jamil; Ali, Amjad


    Acinetobacter baumannii has emerged as a significant nosocomial pathogen during the last few years, exhibiting resistance to almost all major classes of antibiotics. Alternative treatment options such as vaccines tend to be most promising and cost effective approaches against this resistant pathogen. In the current study, we have explored the pan-genome of A. baumannii followed by immune-proteomics and reverse vaccinology approaches to identify potential core vaccine targets. The pan-genome of all available A. baumannii strains (30 complete genomes) is estimated to contain 7,606 gene families and the core genome consists of 2,445 gene families (~32 % of the pan-genome). Phylogenetic tree, comparative genomic and proteomic analysis revealed both intra- and inter genomic similarities and evolutionary relationships. Among the conserved core genome, thirteen proteins, including P pilus assembly protein, pili assembly chaperone, AdeK, PonA, OmpA, general secretion pathway protein D, FhuE receptor, Type VI secretion system OmpA/MotB, TonB dependent siderophore receptor, general secretion pathway protein D, outer membrane protein, peptidoglycan associated lipoprotein and peptidyl-prolyl cis-trans isomerase are identified as highly antigenic. Epitope mapping of the target proteins revealed the presence of antigenic surface exposed 9-mer T-cell epitopes. Protein-protein interaction and functional annotation have shown their involvement in significant biological and molecular processes. The pipeline is validated by predicting already known immunogenic targets against Gram negative pathogen Helicobacter pylori as a positive control. The study, based upon combinatorial approach of pan-genomics, core genomics, proteomics and reverse vaccinology led us to find out potential vaccine candidates against A. baumannii. The comprehensive analysis of all the completely sequenced genomes revealed thirteen putative antigens which could elicit substantial immune response. The integration

  9. Core BPEL

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  10. Core BPEL

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  11. A process-based framework to guide nurse practitioners integration into primary healthcare teams: results from a logic analysis.

    Contandriopoulos, Damien; Brousselle, Astrid; Dubois, Carl-Ardy; Perroux, Mélanie; Beaulieu, Marie-Dominique; Brault, Isabelle; Kilpatrick, Kelley; D'Amour, Danielle; Sansgter-Gormley, Esther


    Integrating Nurse Practitioners into primary care teams is a process that involves significant challenges. To be successful, nurse practitioner integration into primary care teams requires, among other things, a redefinition of professional boundaries, in particular those of medicine and nursing, a coherent model of inter- and intra- professional collaboration, and team-based work processes that make the best use of the subsidiarity principle. There have been numerous studies on nurse practitioner integration, and the literature provides a comprehensive list of barriers to, and facilitators of, integration. However, this literature is much less prolific in discussing the operational level implications of those barriers and facilitators and in offering practical recommendations. In the context of a large-scale research project on the introduction of nurse practitioners in Quebec (Canada) we relied on a logic-analysis approach based, on the one hand on a realist review of the literature and, on the other hand, on qualitative case-studies in 6 primary healthcare teams in rural and urban area of Quebec. Five core themes that need to be taken into account when integrating nurse practitioners into primary care teams were identified. Those themes are: planning, role definition, practice model, collaboration, and team support. The present paper has two objectives: to present the methods used to develop the themes, and to discuss an integrative model of nurse practitioner integration support centered around these themes. It concludes with a discussion of how this framework contributes to existing knowledge and some ideas for future avenues of study.

  12. Measurement and analysis of fractures in vertical, slant, and horizontal core, with examples from the Mesaverde formation

    Lorenz, J.C. (Sandia National Labs., Albuquerque, NM (United States)); Hill, R.E. (CER Corp., Las Vegas, NV (United States))


    Optimum analysis of natural fracture characteristics and distributions in reservoirs requires conscientious supervision of coring operations, on-site core processing, careful layout and marketing of the core, and detailed measurement of fracture characteristics. Natural fractures provide information on the in situ permeability system, and coring-induced fractures provide data on the in situ stresses. Fracture data derived from vertical core should include fracture height, type and location of fracture terminations with respect to lithologic heterogeneity, fracture planatary and roughness, and distribution with depth. Fractures in core from either a vertical or a deviated well will yield information on dip, dip azimuth, strike, mineralization, and the orientation of fractures relative to the in situ stresses. Only measurements of fractures in core from a deviated/horizontal well will provide estimates of fracture spacing and porosity. These data can be graphed and cross-plotted to yield semi-quantitative fracture characteristics for reservoir models. Data on the orientations of fractures relative to each other in unoriented core can be nearly as useful as the absolute orientations of fractures. A deviated pilot hole is recommended for fracture assessment prior to a drilling horizontal production well because it significantly enhances the chances of fracture intersection, and therefore of fracture characterization. 35 refs., 20 figs., 2 tabs.

  13. Primary duodenal neoplasms: A retrospective clinico-pathological analysis

    Bal, Amanjit; Joshi, Kusum; Vaiphei, Kim; Wig, JD


    AIM: To analyze the clinico-pathological spectrum of primary duodenal neoplasms. METHODS: A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study. Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors. RESULTS: On histopathological examination primary duodenal neoplasms were categorized as: epithelial tumor in 27 cases (49.0%) including 10 cases of adenoma, 15 cases of adenocarcinoma, and 2 cases of Brunner gland adenoma; mesenchymal tumor in 9 cases (16.3%) consisting of 4 cases of gastrointestinal stromal tumor, 4 cases of smooth muscle tumor and I case of neurofibroma; lymphoproliferative tumor in 12 cases (21.8%), and neuroendocrine tumor in 7 cases (12.7%). CONCLUSION: Although non-ampullary/periampullary duodenal adenocarcinomas are rare, they constitute the largest group. Histopathological examination of primary duodenal tumors is important for correct histological subtyping. PMID:17373748

  14. Primary duodenal neoplasms:A retrospective clinico-pathological analysis

    Amanjit Bal; Kusum Joshi; Kim Vaiphei; JD Wig


    AIM:To analyze the clinico-pathological spectrum of primary duodenal neoplasms.METHODS:A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study.Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors.RESULTS:On histopathological examination primary duodenal neoplasms were categorized as:epithelial tumor in 27 cases(49.0%)including 10 cases of adenoma,15 cases of adenocarcinoma,and 2 cases of Brunner gland adenoma;mesenchymal tumor in 9 cases (16.3%)consisting of 4 cases of gastrointestinal stromal tumor,4 cases of smooth muscle tumor and I case of neurofibroma;lymphoproliferative tumor in 12 cases (21.8%),and neuroendocrine tumor in 7 cases(12.7%).CONCLUSION:Although non-ampullary/periampullary duodenal adenocarcinomas are rare,they constitute the largest group.Histopathological examination of primary duodenal tumors is important for correct histological subtyping.

  15. An Empirical Analysis of Primary Teacher Standards in Vietnam

    Griffin, Patrick; Cuc, Nguyen Thi Kim; Gillis, Shelley; Thanh, Mai Thi


    This article presents an account of the development of competency standards and profiles for primary teachers in Vietnam. The development project has taken more than four years and used a combination of consultative, actuarial, and item response modeling procedures to develop and validate a scale of teacher competence. In the overall project, more…


    Shui-qing Ma; Chun-mei Bai; Sen Zhong; Xiao-hong Yu; Jing-he Lang


    Objective To investigate the clinical and pathological characteristics of primary cervical malignant melanoma,and its prognosis.Methods The clinical and pathological data of four patients with primary malignant melanoma of the cervix were analyzed retrospectively. Nerve tissue protein S-100 and monoclonal antibody to melanoma (HMB-45) were measured in all cases by immunohistochemical method. All four patients received radical hysterectomy. Three of them received chemotherapy preoperation or postoperation, and one of them received biotherapy with interferon-γ and interleukin-2 at the same time. All the cases were followed up.Results The average age of four patients was 45 years. Clinical symptoms presented with irregular vaginal bleeding,postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix. All the four cases were pathologically diagnosed with cervical malignant melanoma. S-100 and HMB-45 were positive in all patients. Two patients died at 6 and 41 months postoperation, respectively. The other two patients survived for 3.5 and 7 years postoperation, respectively.Conclusions S-100 protein and HMB-45 play very important roles in the diagnosis of primary malignant melanoma of cervix. Radical hysterectomy, chemotherapy combined with dimethyl triazemo imidazole carboxamide and biological therapies may improve the prognosis of the primary malignant melanoma of cervix ifthe disease could be diagnosed in an early stage.

  17. An Analysis of Primary School Dropout Patterns in Honduras

    Sekiya, Takeshi; Ashida, Akemi


    This study hypothesized that repeating a grade is one reason why Honduran primary students drop out of school but not the main reason. Using longitudinal data, we analyzed student enrollment patterns up until students left school. The results revealed that many students dropped out suddenly without having previously repeated a grade, although many…

  18. An Analysis of Primary School Dropout Patterns in Honduras

    Sekiya, Takeshi; Ashida, Akemi


    This study hypothesized that repeating a grade is one reason why Honduran primary students drop out of school but not the main reason. Using longitudinal data, we analyzed student enrollment patterns up until students left school. The results revealed that many students dropped out suddenly without having previously repeated a grade, although many…

  19. Universal Primary Education among Tribals in Jharkhand: A Situational Analysis

    Kumar, Anant


    The paper is an attempt to understand and analyse the status of universal primary education among tribals in Jharkhand and its challenges. Considering the low literacy among tribals and high drop out rates at elementary and higher levels, there is need of special focus on tribal's education, inclusive of context-specific traditional and innovative…

  20. Primary prevention in public health: an analysis of basic assumptions.

    Ratcliffe, J; Wallack, L


    The common definition of primary prevention is straightforward; but how it is transformed into a framework to guide action is based on personal and societal feelings and beliefs about the basis for social organization. This article focuses on the two contending primary prevention strategies of health promotion and health protection. The contention between the two strategies stems from a basic disagreement about disease causality in modern society. Health promotion is based on the "lifestyle" theory of disease causality, which sees individual health status linked ultimately to personal decisions about diet, stress, and drug habits. Primary prevention, from this perspective, entails persuading individuals to forgo their risk-taking, self-destructive behavior. Health protection, on the other hand, is based on the "social-structural" theory of disease causality. This theory sees the health status of populations linked ultimately to the unequal distribution of social resources, industrial pollution, occupational stress, and "anti-health promotion" marketing practices. Primary prevention, from this perspective, requires changing existing social and, particularly, economic policies and structures. In order to provide a basis for choosing between these contending strategies, the demonstrated (i.e., past) impact of each strategy on the health of the public is examined. Two conclusions are drawn. First, the health promotion strategy shows little potential for improving the public health, because it systematically ignores the risk-imposing, other-destructive behavior of influential actors (policy-makers and institutions) in society. And second, effective primary prevention efforts entail an "upstream" approach that results in far-reaching sociopolitical and economic change.

  1. Two Step Procedure Using a 1-D Slab Spectral Geometry in a Pebble Bed Reactor Core Analysis

    Lee, Hyun Chul; Kim, Kang Seog; Noh, Jae Man; Joo, Hyung Kook [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)


    A strong spectral interaction between the core and the reflector has been one of the main concerns in the analysis of pebble bed reactor cores. To resolve this problem, VSOP adopted iteration between the spectrum calculation in a spectral zone and the global core calculation. In VSOP, the whole problem domain is divided into many spectral zones in which the fine group spectrum is calculated using bucklings for fast groups and albedos for thermal groups from the global core calculation. The resulting spectrum in each spectral zone is used to generate broad group cross sections of the spectral zone for the global core calculation. In this paper, we demonstrate a two step procedure in a pebble bed reactor core analysis. In the first step, we generate equivalent cross sections from a 1-D slab spectral geometry model with the help of the equivalence theory. The equivalent cross sections generated in this way include the effect of the spectral interaction between the core and the reflector. In the second step, we perform a diffusion calculation using the equivalent cross sections generated in the first step. A simple benchmark problem derived from the PMBR-400 Reactor was introduced to verify this approach. We compared the two step solutions with the Monte Carlo (MC) solutions for the problem.

  2. Documented Safety Analysis Addendum for the Neutron Radiography Reactor Facility Core Conversion

    Boyd D. Christensen


    The Neutron Radiography Reactor Facility (NRAD) is a Training, Research, Isotope Production, General Atomics (TRIGA) reactor which was installed in the Idaho National Laboratory (INL) Hot Fuels Examination Facility (HFEF) at the Materials and Fuels Complex (MFC) in the mid 1970s. The facility provides researchers the capability to examine both irradiated and non-irradiated materials in support of reactor fuel and components programs through non-destructive neutron radiography examination. The facility has been used in the past as one facet of a suite of reactor fuels and component examination facilities available to researchers at the INL and throughout the DOE complex. The facility has also served various commercial research activities in addition to the DOE research and development support. The reactor was initially constructed using Fuel Lifetime Improvement Program (FLIP)- type highly enriched uranium (HEU) fuel obtained from the dismantled Puerto Rico Nuclear Center (PRNC) reactor. In accordance with international non-proliferation agreements, the NRAD core will be converted to a low enriched uranium (LEU) fuel and will continue to utilize the PRNC control rods, control rod drives, startup source, and instrument console as was previously used with the HEU core. The existing NRAD Safety Analysis Report (SAR) was created and maintained in the preferred format of the day, combining sections of both DOE-STD-3009 and Nuclear Regulatory Commission Regulatory Guide 1.70. An addendum was developed to cover the refueling and reactor operation with the LEU core. This addendum follows the existing SAR format combining required formats from both the DOE and NRC. This paper discusses the project to successfully write a compliant and approved addendum to the existing safety basis documents.

  3. Coring-out fistulectomy with a newly designed 'fistulectome' for complicated perianal fistulae: a retrospective clinical analysis.

    Tasci, I; Erturk, S; Alver, O


    Conventional surgery for complex anal fistula (AF) is associated with continence disturbance and recurrence. In the hope of reducing these we developed a new mechanical device, the 'fistulectome', to excise the entire fistula tract. Between March 2001 and April 2011, 136 patients underwent surgery for a complex AF using the fistulectome. All fistulae were cryptoglandular in origin. Five patients were lost to follow up and were excluded from the analysis. Of the 131 fistulae, 76 were trans-sphincteric, 14 were suprasphincteric and 16 were extrasphincteric. Seven had a horseshoe extension and 18 were unclassified. Of the 131, 108 had recurred after conventional fistulotomy performed at another centre and 23 were primary. The mean duration of follow up was 34.6 months, the mean hospital stay was 5 days and the healing time was 14 days. Recurrence, flatus incontinence and soiling occurred in 17 (12.9%), four (3.5%) and two (1.52%) patients. The results of this series suggest that coring-out of a fistula using a fistulectome may be a valid treatment for complicated anal fistula. © 2013 The Authors Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.

  4. Automatic analysis of the micronucleus test in primary human lymphocytes using image analysis.

    Frieauff, W; Martus, H J; Suter, W; Elhajouji, A


    The in vitro micronucleus test (MNT) is a well-established test for early screening of new chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic potential of a test compound, micronucleus induction in cells has been shown repeatedly to be a sensitive and a specific parameter. Various automated systems to replace the tedious and time-consuming visual slide analysis procedure as well as flow cytometric approaches have been discussed. The ROBIAS (Robotic Image Analysis System) for both automatic cytotoxicity assessment and micronucleus detection in human lymphocytes was developed at Novartis where the assay has been used to validate positive results obtained in the MNT in TK6 cells, which serves as the primary screening system for genotoxicity profiling in early drug development. In addition, the in vitro MNT has become an accepted alternative to support clinical studies and will be used for regulatory purposes as well. The comparison of visual with automatic analysis results showed a high degree of concordance for 25 independent experiments conducted for the profiling of 12 compounds. For concentration series of cyclophosphamide and carbendazim, a very good correlation between automatic and visual analysis by two examiners could be established, both for the relative division index used as cytotoxicity parameter, as well as for micronuclei scoring in mono- and binucleated cells. Generally, false-positive micronucleus decisions could be controlled by fast and simple relocation of the automatically detected patterns. The possibility to analyse 24 slides within 65h by automatic analysis over the weekend and the high reproducibility of the results make automatic image processing a powerful tool for the micronucleus analysis in primary human lymphocytes. The automated slide analysis for the MNT in human lymphocytes complements the portfolio of image analysis applications on ROBIAS which is supporting various assays at Novartis.

  5. Cool Core Clusters from Cosmological Simulations

    Rasia, E; Murante, G; Planelles, S; Beck, A M; Biffi, V; Ragone-Figueroa, C; Granato, G L; Steinborn, L K; Dolag, K


    We present results obtained from a set of cosmological hydrodynamic simulations of galaxy clusters, aimed at comparing predictions with observational data on the diversity between cool-core and non-cool-core clusters. Our simulations include the effects of stellar and AGN feedback and are based on an improved version of the Smoothed-Particle-Hydrodynamics code GADGET-3, which ameliorates gas mixing and better captures gas-dynamical instabilities by including a suitable artificial thermal diffusion. In this Letter, we focus our analysis on the entropy profiles, our primary diagnostic to classify the degree of cool-coreness of clusters, and on the iron profiles. In keeping with observations, our simulated clusters display a variety of behaviors in entropy profiles: they range from steadily decreasing profiles at small radii, characteristic of cool-core systems, to nearly flat core isentropic profiles, characteristic of non cool-core systems. Using observational criteria to distinguish between the two classes of...

  6. Core Fueling and Edge Particle Flux Analysis in Ohmically and Auxiliary Heated NSTX Plasmas

    V.A. Soukhanovskii; R. Maingi; R. Raman; H.W. Kugel; B.P. LeBlanc; L. Roquemore; C.H. Skinner; NSTX Research Team


    The Boundary Physics program of the National Spherical Torus Experiment (NSTX) is focusing on optimization of the edge power and particle flows in b * 25% L- and H-mode plasmas of t {approx} 0.8 s duration heated by up to 6 MW of high harmonic fast wave and up to 5 MW of neutral beam injection. Particle balance and core fueling efficiencies of low and high field side gas fueling of L-mode homic and NBI heated plasmas have been compared using an analytical zero dimensional particle balance model and measured ion and neutral fluxes. Gas fueling efficiencies are in the range of 0.05-0.20 and do not depend on discharge magnetic configuration, density or poloidal location of the injector. The particle balance modeling indicates that the addition of HFS fueling results in a reversal of the wall loading rate and higher wall inventories. Initial particle source estimates obtained from neutral pressure and spectroscopic measurements indicate that ion flux into the divertor greatly exceeds midplane ion flux from the main plasma, suggesting that the scrape-off cross-field transport plays a minor role in diverted plasmas. Present analysis provides the basis for detailed fluid modeling of core and edge particle flows and particle confinement properties of NSTX plasmas. This research was supported by the U.S. Department of Energy under contracts No. DE-AC02-76CH03073, DE-AC05-00OR22725, and W-7405-ENG-36.

  7. Numerical analysis for the matching of the core driven compression system in a double bypass engine

    ZHANG Xin; LIU Bao-jie


    The numerical analysis for the matching of the core driven compression system in a double bypass variable cycle engine was presented in this paper. The system consists of a one-stage-core driven fan stage (CDFS), an inner bypass duet and a five-stage high pressure compressor (HPC), providing two basic operating modes: the single bypass mode and the double bypass mode. Variable vanes are necessary to realize the mode switch of the system. The correct matching in the double bypass mode requires a proper combination of the mass flow, total pressure ratio and blade speed. The work capacity of the system decreases in the double bypass mode and the pressure ratio tends to decrease more for the CDFS and the front stages of the HPC. The overall system efficiency is higher in the double bypass mode. The radial distributions of aerodynamic parameters are similar in different modes. The notable redistribution of mass flow downstream the CDFS in the single bypass mode leads to strong radial flows and additional mixing losses. The absolute flow angles into the inner bypass increase for the inner span and decrease for the outer span when the system is switched from the single bypass mode to the double bypass mode.

  8. Rare earth elements in core marine sediments of coastal East Malaysia by instrumental neutron activation analysis.

    Ashraf, Ahmadreza; Saion, Elias; Gharibshahi, Elham; Mohamed Kamari, Halimah; Chee Kong, Yap; Suhaimi Hamzah, Mohd; Suhaimi Elias, Md


    A study was carried out on the concentration of REEs (Dy, Sm, Eu,Yb, Lu, La and Ce) that are present in the core marine sediments of East Malaysia from three locations at South China Sea and one location each at Sulu Sea and Sulawesi Sea. The sediment samples were collected at a depth of between 49 and 109 m, dried, and crushed to powdery form. The entire core sediments prepared for Instrumental Neutron Activation Analysis (INAA) were weighted approximately 0.0500 g to 0.1000 g for short irradiation and 0.1500 g to 0.2000 g for long irradiation. The samples were irradiated with a thermal neutron flux of 4.0×10(12) cm(-2) s(-1) in a TRIGA Mark II research reactor operated at 750 kW. Blank samples and standard reference materials SL-1 were also irradiated for calibration and quality control purposes. It was found that the concentration of REEs varies in the range from 0.11 to 36.84 mg/kg. The chondrite-normalized REEs for different stations suggest that all the REEs are from similar origins. There was no significant REEs contamination as the enrichment factors normalized for Fe fall in the range of 0.42-2.82. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome.

    Kulohoma, Benard W; Cornick, Jennifer E; Chaguza, Chrispin; Yalcin, Feyruz; Harris, Simon R; Gray, Katherine J; Kiran, Anmol M; Molyneux, Elizabeth; French, Neil; Parkhill, Julian; Faragher, Brian E; Everett, Dean B; Bentley, Stephen D; Heyderman, Robert S


    Streptococcus pneumoniae is a nasopharyngeal commensal that occasionally invades normally sterile sites to cause bloodstream infection and meningitis. Although the pneumococcal population structure and evolutionary genetics are well defined, it is not clear whether pneumococci that cause meningitis are genetically distinct from those that do not. Here, we used whole-genome sequencing of 140 isolates of S. pneumoniae recovered from bloodstream infection (n = 70) and meningitis (n = 70) to compare their genetic contents. By fitting a double-exponential decaying-function model, we show that these isolates share a core of 1,427 genes (95% confidence interval [CI], 1,425 to 1,435 genes) and that there is no difference in the core genome or accessory gene content from these disease manifestations. Gene presence/absence alone therefore does not explain the virulence behavior of pneumococci that reach the meninges. Our analysis, however, supports the requirement of a range of previously described virulence factors and vaccine candidates for both meningitis- and bacteremia-causing pneumococci. This high-resolution view suggests that, despite considerable competency for genetic exchange, all pneumococci are under considerable pressure to retain key components advantageous for colonization and transmission and that these components are essential for access to and survival in sterile sites.

  10. Efficient Design and Analysis of Lightweight Reinforced Core Sandwich and PRSEUS Structures

    Bednarcyk, Brett A.; Yarrington, Phillip W.; Lucking, Ryan C.; Collier, Craig S.; Ainsworth, James J.; Toubia, Elias A.


    Design, analysis, and sizing methods for two novel structural panel concepts have been developed and incorporated into the HyperSizer Structural Sizing Software. Reinforced Core Sandwich (RCS) panels consist of a foam core with reinforcing composite webs connecting composite facesheets. Boeing s Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) panels use a pultruded unidirectional composite rod to provide axial stiffness along with integrated transverse frames and stitching. Both of these structural concepts are ovencured and have shown great promise applications in lightweight structures, but have suffered from the lack of efficient sizing capabilities similar to those that exist for honeycomb sandwich, foam sandwich, hat stiffened, and other, more traditional concepts. Now, with accurate design methods for RCS and PRSEUS panels available in HyperSizer, these concepts can be traded and used in designs as is done with the more traditional structural concepts. The methods developed to enable sizing of RCS and PRSEUS are outlined, as are results showing the validity and utility of the methods. Applications include several large NASA heavy lift launch vehicle structures.

  11. Torque Characteristic Analysis of a Transverse Flux Motor Using a Combined-Type Stator Core

    Xiaobao Yang


    Full Text Available An external rotor transverse flux motor using a combined-type stator core is proposed for a direct drive application in this paper. The stator core is combined by two kinds of components that can both be manufactured conveniently by generic laminated silicon steel used in traditional motors. The motor benefits from the predominance of low manufacturing cost and low iron loss by using a silicon-steel sheet. Firstly, the basic structure and operation principles of the proposed motor are introduced. Secondly, the expressions of the electromagnetic torque and the cogging torque are deduced by theoretical analysis. Thirdly, the basic characteristics such as permanent magnet flux linkage, no-load back electromotive force, cogging torque and electromagnetic torque are analyzed by a three-dimensional finite element method (3D FEM. Then, the influence of structure parameters on the torque density is investigated, which provides a useful foundation for optimum design of the novel motor. Finally, the torque density of the proposed motor is calculated and discussed, and the result shows that the proposed motor in this paper can provide considerable torque density by using few permanent magnets.

  12. Mutagenicity in a Molecule: Identification of Core Structural Features of Mutagenicity Using a Scaffold Analysis.

    Kuo-Hsiang Hsu

    Full Text Available With advances in the development and application of Ames mutagenicity in silico prediction tools, the International Conference on Harmonisation (ICH has amended its M7 guideline to reflect the use of such prediction models for the detection of mutagenic activity in early drug safety evaluation processes. Since current Ames mutagenicity prediction tools only focus on functional group alerts or side chain modifications of an analog series, these tools are unable to identify mutagenicity derived from core structures or specific scaffolds of a compound. In this study, a large collection of 6512 compounds are used to perform scaffold tree analysis. By relating different scaffolds on constructed scaffold trees with Ames mutagenicity, four major and one minor novel mutagenic groups of scaffold are identified. The recognized mutagenic groups of scaffold can serve as a guide for medicinal chemists to prevent the development of potentially mutagenic therapeutic agents in early drug design or development phases, by modifying the core structures of mutagenic compounds to form non-mutagenic compounds. In addition, five series of substructures are provided as recommendations, for direct modification of potentially mutagenic scaffolds to decrease associated mutagenic activities.

  13. Non-destructive X-ray Computed Tomography (XCT) Analysis of Sediment Variance in Marine Cores

    Oti, E.; Polyak, L. V.; Dipre, G.; Sawyer, D.; Cook, A.


    Benthic activity within marine sediments can alter the physical properties of the sediment as well as indicate nutrient flux and ocean temperatures. We examine burrowing features in sediment cores from the western Arctic Ocean collected during the 2005 Healy-Oden TransArctic Expedition (HOTRAX) and from the Gulf of Mexico Integrated Ocean Drilling Program (IODP) Expedition 308. While traditional methods for studying bioturbation require physical dissection of the cores, we assess burrowing using an X-ray computed tomography (XCT) scanner. XCT noninvasively images the sediment cores in three dimensions and produces density sensitive images suitable for quantitative analysis. XCT units are recorded as Hounsfield Units (HU), where -999 is air, 0 is water, and 4000-5000 would be a higher density mineral, such as pyrite. We rely on the fundamental assumption that sediments are deposited horizontally, and we analyze the variance over each flat-lying slice. The variance describes the spread of pixel values over a slice. When sediments are reworked, drawing higher and lower density matrix into a layer, the variance increases. Examples of this can be seen in two slices in core 19H-3A from Site U1324 of IODP Expedition 308. The first slice, located 165.6 meters below sea floor consists of relatively undisturbed sediment. Because of this, the majority of the sediment values fall between 1406 and 1497 HU, thus giving the slice a comparatively small variance of 819.7. The second slice, located 166.1 meters below sea floor, features a lower density sediment matrix disturbed by burrow tubes and the inclusion of a high density mineral. As a result, the Hounsfield Units have a larger variance of 1,197.5, which is a result of sediment matrix values that range from 1220 to 1260 HU, the high-density mineral value of 1920 HU and the burrow tubes that range from 1300 to 1410 HU. Analyzing this variance allows us to observe changes in the sediment matrix and more specifically capture

  14. Numerical analysis and experiment to identify origin of buckling in rapid cycling synchrotron core

    Morita, Y., E-mail: [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki (Japan); Kageyama, T. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki (Japan); Akoshima, M. [The National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono, Tsukuba, Ibaraki (Japan); Torizuka, S.; Tsukamoto, M. [National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukuba, Ibaraki (Japan); Yamashita, S. [International Center for Elementary Particle Physics (ICEPP), University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo (Japan); Yoshikawa, N. [Institute of Industrial Science (IIS), University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo (Japan)


    The accelerating cavities used in the rapid cycling synchrotron (RCS) of the Japan Proton Accelerator Research Complex (J-PARC) are loaded with magnetic alloy (MA) cores. Over lengthly periods of RCS operation, significant reductions in the impedance of the cavities resulting from the buckling of the cores were observed. A series of thermal structural simulations and compressive strength tests showed that the buckling can be attributed to the low-viscosity epoxy resin impregnation of the MA core that causes the stiffening of the originally flexible MA–ribbon–wound core. Our results showed that thermal stress can be effectively reduced upon using a core that is not epoxy-impregnated. -- Highlights: • Study to identify the origin of buckling in the MA cores is presented. • Thermal stress simulations and compressive strength tests were carried out. • Results show that thermal stress is the origin of core buckling. • Thermal stress can be reduced by using cores without epoxy impregnation.

  15. Crosstalk analysis in homogeneous multi-core two-mode fiber under bent condition.

    Chang, J H; Choi, H G; Bae, S H; Sim, D H; Kim, Hoon; Chung, Y C


    We analyze the inter-core crosstalk in homogeneous multi-core two-mode fibers (MC-TMFs) under bent condition by using the coupled-mode equations. In particular, we investigate the effects of the intra-core mode coupling on the inter-core crosstalk for two different types of MC-TMFs at various bending radii. The results show that the inter-core homo-mode crosstalk of LP(11) mode is dominant under the gentle fiber bending condition due to its large effective area. However, as the fiber bending becomes tight, the intra-core mode coupling is significantly enhanced and consequently makes all the inter-core crosstalk levels comparable to each other regardless of the mode. A similar tendency is observed at a reduced bending radius when the difference in the propagation constants between modes is large and core pitch is small.

  16. Reactor Core Coolability Analysis during Hypothesized Severe Accidents of OPR1000

    Lee, Yongjae; Seo, Seungwon; Kim, Sung Joong [Hanyang University, Seoul (Korea, Republic of); Ha, Kwang Soon; Kim, Hwan-Yeol [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    Assessment of the safety features over the hypothesized severe accidents may be performed experimentally or numerically. Due to the considerable time and expenditures, experimental assessment is implemented only to the limited cases. Therefore numerical assessment has played a major role in revisiting severe accident analysis of the existing or newly designed power plants. Computer codes for the numerical analysis of severe accidents are categorized as the fast running integral code and detailed code. Fast running integral codes are characterized by a well-balanced combination of detailed and simplified models for the simulation of the relevant phenomena within an NPP in the case of a severe accident. MAAP, MELCOR and ASTEC belong to the examples of fast running integral codes. Detailed code is to model as far as possible all relevant phenomena in detail by mechanistic models. The examples of detailed code is SCDAP/RELAP5. Using the MELCOR, Carbajo. investigated sensitivity studies of Station Black Out (SBO) using the MELCOR for Peach Bottom BWR. Park et al. conduct regulatory research of the PWR severe accident. Ahn et al. research sensitivity analysis of the severe accident for APR1400 with MELCOR 1.8.4. Lee et al. investigated RCS depressurization strategy and developed a core coolability map for independent scenarios of Small Break Loss-of-Coolant Accident (SBLOCA), SBO, and Total Loss of Feed Water (TLOFW). In this study, three initiating cases were selected, which are SBLOCA without SI, SBO, and TLOFW. The initiating cases exhibit the highest probability of transitioning into core damage according to PSA 1 of OPR 1000. The objective of this study is to investigate the reactor core coolability during hypothesized severe accidents of OPR1000. As a representative indicator, we have employed Jakob number and developed JaCET and JaMCT using the MELCOR simulation. Although the RCS pressures for the respective accident scenarios were different, the JaMCT and Ja

  17. Clinical analysis of primary anaplastic carcinoma of the small intestine

    Tsutomu Namikawa; Kazuhiro Hanazaki


    Primary anaplastic carcinoma is a rare variant of small intestinal cancer. Most reports of primary anaplastic carcinoma of the small intestine are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear. This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the small intestine and investigates key differences from differentiated adenocarcinoma of the small intestine. A Medline search was performed using the keywords 'small intestine' and 'anaplastic carcinoma' or 'undifferentiated carcinoma'. Additional articles were obtained from references with in the papers identified by the Medline search. The literature revealed a poor prognosis for patients who underwent surgical resection for anaplastic carcinoma of the small intestine, which gave a 3-year overall survival rate of 10.8% and a median survival time of 5.0 mo. The literature suggests that anaplastic carcinoma is markedly more aggressive than differentiated adenocarcinoma of the small intestine. Surgical resection with the aim of complete tumor removal provides the only beneficial therapeutic option for patients with anaplastic carcinoma of the small intestine, because chemotherapy and radiation therapy have no significant effect on the rate of survival. However, despite complete tumor resection, most patients with anaplastic carcinoma of the small intestine are at great risk of disease recurrence. Multicenter clinical trials are expected to provide additional therapeutic strategies and establish the efficacy of multimodality adjuvant therapy. This report also highlights the importance of a systematic diagnostic approach for anaplastic carcinoma of the small intestine.

  18. Radiocarbon analysis of stratospheric CO2 retrieved from AirCore sampling

    Paul, Dipayan; Chen, Huilin; Been, Henk A.; Kivi, Rigel; Meijer, Harro A. J.


    Radiocarbon (14C) is an important atmospheric tracer and one of the many used in the understanding of the global carbon budget, which includes the greenhouse gases CO2 and CH4. Measurement of radiocarbon in atmospheric CO2 generally requires the collection of large air samples (a few liters) from which CO2 is extracted and then the concentration of radiocarbon is determined using accelerator mass spectrometry (AMS). However, the regular collection of air samples from the stratosphere, for example using aircraft and balloons, is prohibitively expensive. Here we describe radiocarbon measurements in stratospheric CO2 collected by the AirCore sampling method. AirCore is an innovative atmospheric sampling system, which comprises a long tube descending from a high altitude with one end open and the other closed, and it has been demonstrated to be a reliable, cost-effective sampling system for high-altitude profile (up to ≈ 30 km) measurements of CH4 and CO2. In Europe, AirCore measurements have been being performed on a regular basis near Sodankylä (northern Finland) since September 2013. Here we describe the analysis of samples from two such AirCore flights made there in July 2014, for determining the radiocarbon concentration in stratospheric CO2. The two AirCore profiles were collected on consecutive days. The stratospheric part of the AirCore was divided into six sections, each containing ≈ 35 µg CO2 ( ≈ 9.6 µgC), and stored in a stratospheric air subsampler constructed from 1/4 in. coiled stainless steel tubing ( ≈ 3 m). A small-volume extraction system was constructed that enabled > 99.5 % CO2 extraction from the stratospheric air samples. Additionally, a new small-volume high-efficiency graphitization system was constructed for graphitization of these extracted CO2 samples, which were measured at the Groningen AMS facility. Since the stratospheric samples were very similar in mass, reference samples were also prepared in the same mass range for

  19. Analysis of the effect of core structure upon dineutron correlation using antisymmetrized molecular dynamics

    Kobayashi, Fumiharu


    We extend the method of antisymmetrized molecular dynamics to investigate dineutron correlation. We apply this method to $^{10}$Be as an example and investigate the motion of two neutrons around a largely deformed $^8$Be core by analyzing the two-neutron overlap function around the core. We show that the core structure plays an important role in dineutron formation and expansion from the core and that the present framework is effective for the studies of dineutron correlation.

  20. Immunofluorescence Analysis and Diagnosis of Primary Ciliary Dyskinesia with Radial Spoke Defects.

    Frommer, Adrien; Hjeij, Rim; Loges, Niki T; Edelbusch, Christine; Jahnke, Charlotte; Raidt, Johanna; Werner, Claudius; Wallmeier, Julia; Große-Onnebrink, Jörg; Olbrich, Heike; Cindrić, Sandra; Jaspers, Martine; Boon, Mieke; Memari, Yasin; Durbin, Richard; Kolb-Kokocinski, Anja; Sauer, Sascha; Marthin, June K; Nielsen, Kim G; Amirav, Israel; Elias, Nael; Kerem, Eitan; Shoseyov, David; Haeffner, Karsten; Omran, Heymut


    Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder caused by several distinct defects in genes responsible for ciliary beating, leading to defective mucociliary clearance often associated with randomization of left/right body asymmetry. Individuals with PCD caused by defective radial spoke (RS) heads are difficult to diagnose owing to lack of gross ultrastructural defects and absence of situs inversus. Thus far, most mutations identified in human radial spoke genes (RSPH) are loss-of-function mutations, and missense variants have been rarely described. We studied the consequences of different RSPH9, RSPH4A, and RSPH1 mutations on the assembly of the RS complex to improve diagnostics in PCD. We report 21 individuals with PCD (16 families) with biallelic mutations in RSPH9, RSPH4A, and RSPH1, including seven novel mutations comprising missense variants, and performed high-resolution immunofluorescence analysis of human respiratory cilia. Missense variants are frequent genetic defects in PCD with RS defects. Absence of RSPH4A due to mutations in RSPH4A results in deficient axonemal assembly of the RS head components RSPH1 and RSPH9. RSPH1 mutant cilia, lacking RSPH1, fail to assemble RSPH9, whereas RSPH9 mutations result in axonemal absence of RSPH9, but do not affect the assembly of the other head proteins, RSPH1 and RSPH4A. Interestingly, our results were identical in individuals carrying loss-of-function mutations, missense variants, or one amino acid deletion. Immunofluorescence analysis can improve diagnosis of PCD in patients with loss-of-function mutations as well as missense variants. RSPH4A is the core protein of the RS head.

  1. Provenance analysis of the SMS ANDRILL core: Trends in sandstone composition

    Bassett, K. N.; Barnard, S.


    The sedimentary fill in the southern McMurdo Sound of the Ross Sea provides a unique record. There are several distinct transitions in sand grain composition in the SMS core that record the advance and retreat of local glaciers draining off the Transantarctic Mountains into the basin, volcanic eruptions associated with rifting, and perhaps the growth and collapse of the West Antarctic ice sheet. Sand grain composition in the uppermost part of the core is dominantly primary volcanic (LSU1) recording derivation from a local basaltic vent that formed as part of the Dailey Islands volcanic field. Other peaks in volcanic glass content occur between ~170-224 m and ~550-660 m indicating periods of increased volcanic activity. Basement-derived grains increase markedly at ~42m, the transition from LSU1 to 2, including quartz, feldspar, biotite, muscovite, chlorite, schist, marble, basalt, and granite lithics associated with a decrease in volcanics and olivine. These record derivation from the Granite Harbour Intrusives and Koettlitz Group metasediments, delivered via the local Blue and Koettlitz Glaciers during the height of Plio-Pleistocene glacial advances. Basement-derived grain concentrations remain high until at ~165 m, mid-way down LSU4, the marble drops out. This may correspond to the minor unconformity at the base of the Pliocene deposits in the core marking the transition to Upper Miocene glaciations. Below this, marble clasts only occur as isolated peaks which may most strongly correlate with a very large Koettlitz Glacier. At ~224 m depth (the transition from LSU4 to 5), muscovite, basalt and olivine decrease and at ~340 m (LSU6 to 7) biotite, granite and amphibole decrease. Isolated increases occur again around ~500 m and ~600 m and may correspond to advances of local glaciers. Well rounded quartz grains, some with attached cements, increase abruptly at ~224 m (LSU4 to 5) and correlate strongly with orthopyroxenes in thin section. These are derived from Beacon

  2. Off-line and on-line noise analysis for core surveillance in French LMFBR 'Anabel'

    Gourdon, J.; Casejuane, R.


    Some results concerning noise analysis studies performed in French LMFBR are presented in support to the design of an on-line noise analysis system to be included in the core surveillance and protection system of SUPER-PHENIX. This computerized system is presented: signal processing, block diagram, operating modes.

  3. Mechanism and numerical analysis of heat transfer enhancement in the core flow along a tube


    The present study introduces the principles of enhanced heat transfer in the core flow to form an equivalent thermal boundary layer in the fully developed laminar tube flow, which consequently enlarges the temperature gradient of the fluid near the tube wall, and thereby enhances the heat transfer between the fluid and the tube wall. At the same time, the increase of flow resistance in the tube is not so obvious. Mechanism analysis and numerical calculation based on air and water have been carried out to verify the principle and method presented in this paper, which may bring positive effects to the design of heat exchanger with high heat transfer efficiency and low flow resistance.

  4. Analysis of cracked core spray piping from the Quad Cities Unit 2 boiling water reactor

    Diercks, D.R.; Gaitonde, S.M.


    The results of a metallurgical analysis of leaking cracks detected in the core spray injection piping of Commonwealth Edison Company's Quad Cities Unit 2 Boiling Water Reactor are described. The cracks were present in a welded 105/sup 0/ elbow assembly in the line, and were found to be caused by intergranular stress corrosion cracking associated with the probable presence of dissolved oxygen in the reactor cooling water and the presence of grain boundary sensitization and local residual stresses induced by welding. The failure is unusual in several respects, including the very large number of cracks (approximately 40) present in the failed component, the axial orientation of the cracks, and the fact that at least one crack completely penetrated a circumferential weld. Virtually all of the cracking occurred in forged material, and the microstructural evidence presented suggests that the orientation of the cracks was influenced by the presence of axially banded delta ferrite in the microstructure of the forged components.

  5. Analysis of the Flexure Behavior and Compressive Strength of Fly Ash Core Sandwiched Composite Material

    Vijaykumar H.K


    Full Text Available In this paper, commercially available Fly Ash and Epoxy is used for the core material, woven glass fabric as reinforcing skin material, epoxy as matrix/adhesive materials used in this study for the construction of sandwich composite. Analysis is carried out on different proportions of epoxy and fly ash sandwiched composite material for determining the flexural strength and compressive strength, three different proportions of epoxy and fly ash used for the study. Those are 65%-35% (65% by weight fly ash and 35% by weight epoxy resin composite material, 60%-40% and 55%-45% composite material. 60%-40% composite material specimen shows better results in the entire test carried out i.e. Flexure and Compression. The complete experimental results are discussed and presented in this paper.

  6. Near Real-time Data Analysis of Core-Collapse Supernova Simulations With Bellerophon

    Lingerfelt, Eric J [ORNL; Messer, Bronson [ORNL; Desai, Sharvari S [University of Tennessee, Knoxville (UTK); Holt, Chastity A [Appalachian State University; Lentz, Eric J [University of Tennessee, Knoxville (UTK)


    We present an overview of a software system, Bellerophon, built to support a production-level HPC application called CHIMERA, which simulates core-collapse supernova events at the petascale. Developed over the last four years, Bellerophon enables CHIMERA s geographically dispersed team of collaborators to perform data analysis in near real-time. Its n-tier architecture provides an encapsulated, end-to-end software solution that enables the CHIMERA team to quickly and easily access highly customizable animated and static views of results from anywhere in the world via a web-deliverable, cross-platform desktop application. In addition, Bellerophon addresses software engineering tasks for the CHIMERA team by providing an automated mechanism for performing regression testing on a variety of supercomputing platforms. Elements of the team s workflow management needs are met with software tools that dynamically generate code repository statistics, access important online resources, and monitor the current status of several supercomputing resources.

  7. Tank 241-SY-101 push mode core sampling and analysis plan

    CONNER, J.M.


    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for push mode core samples from tank 241-SY-101 (SY-101). It is written in accordance with Data Quality Objective to Support Resolution of the Flammable Gas Safety Issue (Bauer 1998), Low Activity Waste Feed Data Quality Objectives (Wiemers and Miller 1997 and DOE 1998), Data Quality Objectives for TWRS Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for Low-Activity Waste Feed Batch X (Certa 1998), and the Tank Safety Screening Data Quality Objective (Dukelow et al. 1995). The Tank Characterization Technical Sampling Basis document (Brown et al. 1998) indicates that these issues apply to tank SY-101 for this sampling event. Brown et al. also identifies high-level waste, regulatory, pretreatment and disposal issues as applicable issues for this tank. However, these issues will not be addressed via this sampling event.

  8. Analysis of some elements in primary enamel during postnatal mineralization.

    Sabel, Nina; Klinberg, Gunilla; Nietzsche, Sandor; Robertson, Agneta; Odelius, Hans; Norén, Jörgen G


    The primary teeth start to mineralize in utero and continue development and maturation during the first year of life.The aim of this study was to investigate the concentrations of some elements, C, F, Na, Mg, Cl, K and Sr, by secondary ion mass spectrometry (SIMS) in human primary incisors at different stages of mineralization.The teeth derived from an autopsy material from children who had died in sudden infant death.The buccal enamel of specimens from the ages 1, 2, 3, 4, 6 and 19 months, respectively, was analyzed. It was evident that posteruptive effects play an important role in composition of the outermost parts of the enamel. Before the tooth erupts, the concentrations of the elements vary with the maturation grade of the mineralization in the enamel. Sodium was the element with the highest concentration of the measured elements and chlorine was the element of lowest concentration.The 19 month old specimen, considered as the only mature and erupted tooth, showed to differ from the other specimens.The concentration of fluorine, in the 19 month old specimen's outermost surface, is readily seen higher compared with the other specimens at this depth zone. In the 19 month old specimen the concentration of carbon is lower. Potassium, sodium and chlorine have higher concentrations, in general, in the 19 month old specimen compared with the immature specimens. The thickness of the enamel during mineralization was calculated from data from SIMS.The thickness of the buccal enamel of primary incisors seemed to be fully developed between 3-4 months after birth, reaching a thickness of 350-400 microm.

  9. Gender bias in primary education a theoretical analysis

    Róbert Osaďan


    Full Text Available For decades, gender bias and inequity have remained extensive issues in nearly all societies in the world. During the past years, the effects of these issues have extended to one of the most important facets in our society - the education sector. Although this may not be immediately shocking, a lot of researchers as well as concerned educators and parents believe otherwise. As a matter of fact, a myriad of studies and research projects have already proven that gender discrimination, bias, and other related issues in sexuality actually exist in most primary schools throughout the globe. These literary materials present vital points that provide the initiative for primary school educators, school administrators, and other parents to become aware of the gender issues, which significantly affect the school performance and achievement of the concerned students, most of them being girls. Also, a number of studies have identified gender bias agents and their contributions in the worsening of the problem. Obviously, this problem needs to be addressed by the people most empowered - the educators. There is no question whether or not primary school teachers possess the knowledge to circumvent this bias inside their classrooms. The true concern is when they will actually start to apply crucial measures to resolve and get rid of gender bias. Once they eliminate their own prejudices about their students in terms of gender- related issues, they will be able to provide each of their pupils the right and proper education that the children deserve to get. And if all students obtain fair educational treatment, academic excellence and competence will merely be two of the countless benefits they can get.

  10. Development of Optimized Core Design and Analysis Methods for High Power Density BWRs

    Shirvan, Koroush

    temperature was kept the same for the BWR-HD and ABWR which resulted in 4 °K cooler core inlet temperature for the BWR-HD given that its feedwater makes up a larger fraction of total core flow. The stability analysis using the STAB and S3K codes showed satisfactory results for the hot channel, coupled regional out-of-phase and coupled core-wide in-phase modes. A RELAPS model of the ABWR system was constructed and applied to six transients for the BWR-HD and ABWR. The 6MCPRs during all the transients were found to be equal or less for the new design and the core remained covered for both. The lower void coefficient along with smaller core volume proved to be advantages for the simulated transients. Helical Cruciform Fuel (HCF) rods were proposed in prior MIT studies to enhance the fuel surface to volume ratio. In this work, higher fidelity models (e.g. CFD instead of subchannel methods for the hydraulic behaviour) are used to investigate the resolution needed for accurate assessment of the HCF design. For neutronics, conserving the fuel area of cylindrical rods results in a different reactivity level with a lower void coefficient for the HCF design. In single-phase flow, for which experimental results existed, the friction factor is found to be sensitive to HCF geometry and cannot be calculated using current empirical models. A new approach for analysis of flow crisis conditions for HCF rods in the context of Departure from Nucleate Boiling (DNB) and dryout using the two phase interface tracking method was proposed and initial results are presented. It is shown that the twist of the HCF rods promotes detachment of a vapour bubble along the elbows which indicates no possibility for an early DNB for the HCF rods and in fact a potential for a higher DNB heat flux. Under annular flow conditions, it was found that the twist suppressed the liquid film thickness on the HCF rods, at the locations of the highest heat flux, which increases the possibility of reaching early dryout. It

  11. A Raman cell based on hollow core photonic crystal fiber for human breath analysis

    Chow, Kam Kong; Zeng, Haishan, E-mail: [Imaging Unit – Integrative Oncology Department, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada and Medical Physics Program – Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1 (Canada); Short, Michael; Lam, Stephen; McWilliams, Annette [Imaging Unit – Integrative Oncology Department, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3 (Canada)


    Purpose: Breath analysis has a potential prospect to benefit the medical field based on its perceived advantages to become a point-of-care, easy to use, and cost-effective technology. Early studies done by mass spectrometry show that volatile organic compounds from human breath can represent certain disease states of our bodies, such as lung cancer, and revealed the potential of breath analysis. But mass spectrometry is costly and has slow-turnaround time. The authors’ goal is to develop a more portable and cost effective device based on Raman spectroscopy and hollow core-photonic crystal fiber (HC-PCF) for breath analysis. Methods: Raman scattering is a photon-molecular interaction based on the kinetic modes of an analyte which offers unique fingerprint type signals that allow molecular identification. HC-PCF is a novel light guide which allows light to be confined in a hollow core and it can be filled with a gaseous sample. Raman signals generated by the gaseous sample (i.e., human breath) can be guided and collected effectively for spectral analysis. Results: A Raman-cell based on HC-PCF in the near infrared wavelength range was developed and tested in a single pass forward-scattering mode for different gaseous samples. Raman spectra were obtained successfully from reference gases (hydrogen, oxygen, carbon dioxide gases), ambient air, and a human breath sample. The calculated minimum detectable concentration of this system was ∼15 parts per million by volume, determined by measuring the carbon dioxide concentration in ambient air via the characteristic Raman peaks at 1286 and 1388 cm{sup −1}. Conclusions: The results of this study were compared to a previous study using HC-PCF to trap industrial gases and backward-scatter 514.5 nm light from them. The authors found that the method presented in this paper has an advantage to enhance the signal-to-noise ratio (SNR). This SNR advantage, coupled with the better transmission of HC-PCF in the near-IR than in the


    Zhao Jingyi; Zhuoru; Wang Yiqun


    According to the demand of high reliability of the primary cylinder of the hydraulic press,the reliability model of the primary cylinder is built after its reliability analysis.The stress of the primary cylinder is analyzed by finite element software-MARC,and the structure reliability of the cylinder based on stress-strength model is predicted,which would provide the reference to the design.

  13. Core Oligosaccharide of Plesiomonas shigelloides PCM 2231 (Serotype O17 Lipopolysaccharide — Structural and Serological Analysis

    Anna Maciejewska


    Full Text Available The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS P. shigelloides Polish Collection of Microorganisms (PCM 2231 (serotype O17 was investigated by 1H, 13C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is composed of an undecasaccharide, which represents the second core type identified for P. shigelloides serotype O17 LPS. This structure is similar to that of the core oligosaccharide of P. shigelloides strains 302-73 (serotype O1 and 7-63 (serotype O17 and differs from these only by one sugar residue. Serological screening of 55 strains of P. shigelloides with the use of serum against identified core oligosaccharide conjugated with bovine serum albumin (BSA indicated the presence of similar structures in the LPS core region of 28 O-serotypes. This observation suggests that the core oligosaccharide structure present in strain PCM 2231 could be the most common type among P. shigelloides lipopolysaccharides.

  14. Primary proton and helium spectra at energy range from 50 TeV to 1015 eV observed with the new Tibet AS core detector array

    Huang Jing


    Full Text Available A new EAS hybrid experiment has been designed by constructing a YAC (Yangbajing Air shower Core detector array inside the existing Tibet-III air shower array. The first step of YAC, called “YAC-I” has been successfully carried out in 2009–2010 together with Tibet-III air-shower array. YAC-II has also been operated from 2011. Preliminary results of YAC-I and performance of YAC-II are presented in this paper. The primary proton and helium spectra at energy range from50 TeV to 1015 eV derived from YAC-I data based on QGSJET2 and SIBYLL2.1 are reported. The obtained P+He spectrum is smoothly connected with directobservation data below 100 TeV and also with our previously reported results at higher energies within statistical error s. Based on these results and the sharp kneeof all-particle energy spectrum observed by our experiment, the possible origin of the sharp knee is discussed. See the published papers.

  15. High speed, high resolution, and continuous chemical analysis of ice cores using a melter and ion chromatography.

    Cole-Dai, Jihong; Budner, Drew M; Ferris, Dave G


    Measurement of trace chemical impurities in ice cores contributes to the reconstruction of records of the atmospheric environment and of the climate system. Ion chromatography (IC) is an effective analytical technique for ionic species in ice cores but has been used on discretely prepared ice samples, resulting in extensive and slow sample preparation and potential for contamination. A new technique has been developed that utilizes IC as the online detection technique in a melter-based continuous flow system for quantitative determination of major ionic chemical impurities. The system, called CFA-IC for continuous flow analysis with ion chromatography detection, consists of an ice core melter, several ion chromatographs, and an interface that distributes meltwater to the IC instruments. The CFA-IC technique combines the accuracy, precision, and ease of use of IC measurement with the enhanced speed and depth resolution of continuous melting systems and is capable of virtually continuous, high-speed and high-resolution chemical analysis of long ice cores. The new technique and operating procedures have been tested and validated with the analysis of over 100 m of ice cores from Antarctica. The current CFA-IC system provides an all-major-ion analysis speed of up to 8 m a day at a depth resolution of approximately 2 cm.

  16. Clinical features and ryanodine receptor type 1 gene mutation analysis in a Chinese family with central core disease.

    Chang, Xingzhi; Jin, Yiwen; Zhao, Haijuan; Huang, Qionghui; Wang, Jingmin; Yuan, Yun; Han, Ying; Qin, Jiong


    Central core disease is a rare inherited neuromuscular disorder caused by mutations in ryanodine receptor type 1 gene. The clinical phenotype of the disease is highly variable. We report a Chinese pedigree with central core disease confirmed by the gene sequencing. All 3 patients in the family presented with mild proximal limb weakness. The serum level of creatine kinase was normal, and electromyography suggested myogenic changes. The histologic analysis of muscle biopsy showed identical central core lesions in almost all of the muscle fibers in the index case. Exon 90-106 in the C-terminal domain of the ryanodine receptor type 1 gene was amplified using polymerase chain reaction. One heterozygous missense mutation G14678A (Arg4893Gln) in exon 102 was identified in all 3 patients. This is the first report of a familial case of central core disease confirmed by molecular study in mainland China.


    Martino, C; Daniel McCabe, D; Tommy Edwards, T; Ralph Nichols, R


    Twelve LM-75 core samplers from Tank 28F sampling were received by SRNL for saltcake characterization. Of these, nine samplers contained mixtures of free liquid and saltcake, two contained only liquid, and one was empty. The saltcake contents generally appeared wet. A summary of the major tasks performed in this work are as follows: (1) Individual saltcake segments were extruded from the samplers and separated into saltcake and free liquid portions. (2) Free liquids were analyzed to estimate the amount of traced drill-string fluid contained in the samples. (3) The saltcake from each individual segment was homogenized, followed by analysis in duplicate. The analysis used more cost-effective and bounding radiochemical analyses rather than using the full Saltstone WAC suite. (4) A composite was created using an approximately equal percentage of each segment's saltcake contents. Supernatant liquid formed upon creation of the composite was decanted prior to use of the composite, but the composite was not drained. (5) A dissolution test was performed on the sample by contacting the composite with water at a 4:1 mass ratio of water to salt. The resulting soluble and insoluble fractions were analyzed. Analysis focused on a large subset of the Saltstone WAC constituents.

  18. Spatial analysis of elderly access to primary care services

    Lozano-Gracia Nancy


    Full Text Available Abstract Background Admissions for Ambulatory Care Sensitive Conditions (ACSCs are considered preventable admissions, because they are unlikely to occur when good preventive health care is received. Thus, high rates of admissions for ACSCs among the elderly (persons aged 65 or above who qualify for Medicare health insurance are signals of poor preventive care utilization. The relevant geographic market to use in studying these admission rates is the primary care physician market. Our conceptual model assumes that local market conditions serving as interventions along the pathways to preventive care services utilization can impact ACSC admission rates. Results We examine the relationships between market-level supply and demand factors on market-level rates of ACSC admissions among the elderly residing in the U.S. in the late 1990s. Using 6,475 natural markets in the mainland U.S. defined by The Health Resources and Services Administration's Primary Care Service Area Project, spatial regression is used to estimate the model, controlling for disease severity using detailed information from Medicare claims files. Our evidence suggests that elderly living in impoverished rural areas or in sprawling suburban places are about equally more likely to be admitted for ACSCs. Greater availability of physicians does not seem to matter, but greater prevalence of non-physician clinicians and international medical graduates, relative to U.S. medical graduates, does seem to reduce ACSC admissions, especially in poor rural areas. Conclusion The relative importance of non-physician clinicians and international medical graduates in providing primary care to the elderly in geographic areas of greatest need can inform the ongoing debate regarding whether there is an impending shortage of physicians in the United States. These findings support other authors who claim that the existing supply of physicians is perhaps adequate, however the distribution of them across

  19. Use Root Cause Analysis Teaching Strategy to Train Primary Pre-Service Science Teachers

    Lu, Chow-chin; Tsai, Chun-wei; Hong, Jon-chao


    This study examined the Root Cause Analysis (RCA) teaching strategy on pre-service primary science teachers and instinct pre-service teachers to apply RCA teaching strategy to science curriculums. RCA Teaching Strategy is to coordinates 5 Why Method and Fishbone Diagram. The participants included 18 pre-service primary science teachers and the…

  20. A clinicopathologic analysis of primary orbital yolk sac tumor

    PENG Ji-ying


    Full Text Available Objective On rare occasions, yolk sac tumor may arise from extragonadal sites. Orbit is an unusual location for the primary development of this tumor. The presence of intracranial yolk sac tumor on biopsy always makes the diagnosis challenge for pathologists. Herein we report a case of intracranial primary yolk sac tumor in left orbital apex. The clinicopathology of this tumor and its differential diagnosis are discussed. Methods The clinical manifestation of a patient with primary yolk sac tumor occurring in left orbital apex was presented retrospectively. Resected orbital mass was routinely paraffin-embedded and stained with hematoxylin and eosin. Dako Envision immunohistochemical staining system was used to detect the tumor antigen expressions, including alpha-fetoprotein (AFP, cytokeratin, placental alkaline phosphatase (PLAP, CD30, CD34, CD45, CD99, CD117, synaptophysin (Syn and chromogranin A (CgA. Results A 2-year-old boy presented with 3-month history of ptosis of eyelid and exophthalmos on left eye. Magnetic resonance imaging (MRI scan revealed a lesion occupied the left orbital apex with infiltration of surrounding normal structure, including left posterior ethmoid sinus, the wall of left maxillary sinus and sphenoid. However, there was no evidence of tumor infiltrating in brain parenchyma. Craniotomy was performed and the tumor was removed by en bloc resection. Grossly, the biopsy specimen received in small pieces was 1.20 cm × 1.00 cm × 1.00 cm when aggregated. No fibrous capsule, necrosis, haemorrhage and gross calcification were found in the tissue fragments. Histological examination revealed that the tumor was arranged in a reticular pattern. The cells were relatively large with a clear cytoplasm and vesicular nuclei. Scattered mitotic figures were noted. Schiller-Duval bodies and periodic acid-Schiff (PAS positive (eosinophilic bodies were evident in the tumor tissue. Immunohistochemical staining showed that the tumor cells

  1. Clinical Analysis of 21 Cases of Primary Breast Malignant Lymphoma

    Liming Wang; Haizeng Zhang; Yongfu Shao


    OBJECTIVE To explore the clinico-pathological characteristics, diagnosis,treatment, and prognosis factors for primary breast malignant lymphoma (PBL).METHODS The clinical data from 21 cases of PBL were retrospectively analysed.RESULTS There were 19 females and 2 males with a median age of 37 years.All cases had diffuse non-Hodgkin lymphoma from B-cell lineage. The overall 5-year survival rate was 62.50% for the whole group and 81.82% for stage Ⅰ and Ⅱ diseases.CONCLUSION The prognosis of PBL is related to the stage and treatment modality. Operation combined with chemoradiotherapy is the best treatment method. Local resection should be the first surgical treatment.

  2. Analysis of High Temperature Reactor Control Rod Worth for the Initial and Full Core

    Oktajianto, Hammam; Setiawati, Evi; Anam, Khoirul; Sugito, Heri


    Control rod is one important component in a nuclear reactor. In nuclear reactor operations the control rod functions to shut down the reactor. This research analyses ten control rods worth of HTR (High Temperature Reactor) at initial and full core. The HTR in this research adopts HTR-10 China and HTR- of pebble bed. Core calculations are performed by using MCNPX code after modelling the entire parts of core in condition of ten control rods fully withdrawn, all control rods in with 20 cm ranges of depth and the use of one control rod. Pebble bed and moderator balls are distributed in the core zone using a Body Centred Cubic (BCC) lattice by ratio of 57:43. The research results are obtained that the use of one control rod will decrease the reactor criticality of 2.04±0.12 %Δk/k at initial core and 1.57±0.10 %Δk/k at full core. The deeper control rods are in, the lesser criticality of reactor is with reactivity of ten control rods of 16.41±0.11 %Δk/k at initial core and 15.43±0.11 %Δk/k at full core. The results show that the use of ten control rods at full core will keep achieving subcritical condition even though the reactivity is smaller than reactivity at initial core.

  3. [Photoelastic stress analysis of root dentin with different composite resin post and core systems and crowns].

    Takei, Hidenori


    Much research has been reported about post and core systems with composite resin, but the influence of the different types of prefabricated posts on the distribution of stress in the root has not yet been elucidated. It is necessary to clarify the influence of the relationship between core and crown materials to obtain combined restorations. The aim of this study is to analyze the influence of the combination of various post and core systems and different kinds of crown material on the stress distribution in the root. Six 2-dimensional photoelastic premolar models were designed. Three types of post and core systems (composite resin post and core, composite resin core with the fiber post, and composite resin core with a prefabricated stainless steel post) and two kinds of crown materials (metal and hybrid-type hard composite resin) were fabricated and cemented to each model. In these models, we applied a load of 200 N at an angle of 45 degrees to the tooth axis and analyzed the fringe order using a transmission polariscope. As a result, it has been clarified that the combination of the post and core and the crown plays an important role in preventing stress concentration within root Stress concentration can be prevented using a crown fabricated with a high-elastic modulus for the post and core with a high-elastic modulus, and a crown fabricated with a low-elastic modulus for the post and core with a low-elastic modulus.

  4. Synthesis, spectral characterization, electron microscopic study and thermogravimetric analysis of a phosphorus containing dendrimer with diphenylsilanediol as core unit

    E. Dadapeer


    Full Text Available A phosphorus containing dendrimer with a diphenylsilanediol core was synthesized using a divergent method. Several types of reactions were performed on dendrons of several sizes, either at the level of the core or the surface. The giant Schiff’s base macro molecule possesses 12 imine bonds and 8 hydroxy groups on the terminal phenyl groups. The structures of the intermediate compounds were confirmed by IR, GCMS and 31P NMR. The final compound was characterized by 1H, 13C, 31P NMR, MALDI-TOF MS and CHN analysis. Scanning electron microscopic and thermogravimetric analysis/differential scanning calorimetric studies were also performed on the final dendritic molecule.

  5. Analysis of hydrologic structures within Mauna Kea volcano using diamond wireline core drilling

    Thomas, D. M.; Haskins, E.


    The Humu'ula Groundwater Research Project was undertaken on the Island of Hawaii in an effort to characterize the hydrologic structures controlling groundwater movement and storage within the dry (~430 mm/year annual rainfall) saddle region between Mauna Loa and Mauna Kea volcanoes. The project drilled a 1764 m, continuously-cored, borehole from an elevation of 1946 m amsl. The shallow stratigraphy consisted of alluvial outwash of clastic debris, of both volcanic and glacial origin, from the upper slopes of Mauna Kea, and was underlain by highly permeable post-shield lavas to depths of a few hundred meters. Below this depth, shield stage lavas were dominated by highly-fractured and permeable pahoehoe lavas and (less common) a'a flows and occasional soil and ash accumulations at flow boundaries. As depths increased below 1000 m, progressive compaction of fragmental material was found at the flow boundaries and, by depths of ~1500 m, much of the void space in the flow boundaries had been collapsed and compacted. Increasing secondary mineralization was observed below about 1000 m depth that was exacerbated by rising temperatures and temperature gradients toward the bottom of the hole. Hydrologic conditions were strikingly different from those predicted by conventional models for ocean islands: the formation was dry down to only ~150 m where the first, thin, perched aquifer was encountered; a second, more substantial, perched aquifer was reached at only ~220 m depth that extended to ~360 m where a sequence of (remarkably thin) perching formations were recovered in the core down to about 420 m where unsaturated rocks were again encountered. Saturated conditions resumed at 550 m depth that continued to the total depth drilled; this latter zone is inferred to be the basal aquifer for Mauna Kea within this region of the island. Our initial analysis of the core suggests that thin, clay-rich, perching formations in the shallow stratigraphic column play a much larger role in

  6. The Use of History and Philosophy of Science as a Core for a Socioconstructivist Teaching Approach of the Concept of Energy in Primary Education

    Rizaki, Aikaterini; Kokkotas, Panagiotis


    The present study should be thought as a socioconstructivist teaching approach (a teaching model) for the concept of energy in primary education. It contains important and crucial aspects of the History and Philosophy of Natural Sciences, introduces the concept of energy using the macroscopic framework of thermodynamics, takes into consideration learners' alternative ideas or frameworks relating to energy, takes advantage of the causal and the unifying characters of energy, which have been founded on the historiographical analysis of this concept, uses energy chains as visual representations for the deep understanding of it, uses visual grammar of Kress and van Leeuwen to design energy chains and introduces a teaching methodology for this concept.

  7. Numerical analysis of primary rainbows from a homogeneous cylinder and an optical fiber for incident low-coherent light

    Świrniak, Grzegorz; Mroczka, Janusz


    This work provides a numerical study of the scattering of low-coherent light by an infinite right circular cylinder and various types of optical fiber (with step- and graded-index profiles) in the vicinity of primary rainbows, caused by light that has been subjected to one internal reflection. The scattered intensity is analyzed in terms of the Fourier transform as well as in the time domain (by examining the impulse response of a fiber) with the aim to obtain a detailed information about the scattering process. The analysis reveals a wealth of information about the scattering process that is not obvious when a fiber is illuminated by a temporally coherent light source. The results also provide an idea for the characterization of the core size of step-index optical fibers.

  8. Analysis of nuclear characteristics and fuel economics for PWR core with homogeneous thorium fuels

    Joo, H. K.; Noh, J. M.; Yoo, J. W.; Song, J. S.; Kim, J. C.; Noh, T. W


    The nuclear core characteristics and economics of an once-through homogenized thorium cycle for PWR were analyzed. The lattice code, HELIOS has been qualified against BNL and B and W critical experiments and the IAEA numerical benchmark problem in advance of the core analysis. The infinite multiplication factor and the evolution of main isotopes with fuel burnup were investigated for the assessment of depletion charateristics of thorium fuel. The reactivity of thorium fuel at the beginning of irradiation is smaller than that of uranium fuel having the same inventory of {sup 235}U, but it decrease with burnup more slowly than in UO{sub 2} fuel. The gadolinia worth in thorium fuel assembly is also slightly smaller than in UO{sub 2} fuel. The inventory of {sup 233}U which is converted from {sup 232}Th is proportional to the initial mass of {sup 232}Th and is about 13kg per one tones of initial heavy metal mass. The followings are observed for thorium fuel cycle compared with UO{sub 2} cycle ; shorter cycle length, more positive MTC at EOC, more negative FTC, similar boron worth and control rod. Fuel economics of thorium cycle was analyzed by investigating the natural uranium requirements, the separative work requirements, and the cost for burnable poison rods. Even though less number of burnable poison rods are required in thorium fuel cycle, the costs for the natural uranium requirements and the separative work requirements are increased in thorium fuel cycle. So within the scope of this study, once through cycle concept, homogenized fuel concept, the same fuel management scheme as uranium cycle, the thorium fuel cycle for PWR does not have any economic incentives in preference to uranium.

  9. Novel targets of sulforaphane in primary cardiomyocytes identified by proteomic analysis.

    Angeloni, Cristina; Turroni, Silvia; Bianchi, Laura; Fabbri, Daniele; Motori, Elisa; Malaguti, Marco; Leoncini, Emanuela; Maraldi, Tullia; Bini, Luca; Brigidi, Patrizia; Hrelia, Silvana


    Cardiovascular diseases represent the main cause of mortality in the industrialized world and the identification of effective preventive strategies is of fundamental importance. Sulforaphane, an isothiocyanate from cruciferous vegetables, has been shown to up-regulate phase II enzymes in cardiomyocytes and counteract oxidative stress-induced apoptosis. Aim of the present study was the identification and characterization of novel sulforaphane targets in cardiomyocytes applying a proteomic approach. Two-dimensional gel electrophoresis and mass spectrometry were used to generate protein profiles of primary neonatal rat cardiomyocytes treated and untreated with 5 µM sulforaphane for 1-48 h. According to image analysis, 64 protein spots were found as differentially expressed and their functional correlations were investigated using the MetaCore program. We mainly focused on 3 proteins: macrophage migration inhibitory factor (MIF), CLP36 or Elfin, and glyoxalase 1, due to their possible involvement in cardioprotection. Validation of the time-dependent differential expression of these proteins was performed by western blotting. In particular, to gain insight into the cardioprotective role of the modulation of glyoxalase 1 by sulforaphane, further experiments were performed using methylglyoxal to mimic glycative stress. Sulforaphane was able to counteract methylglyoxal-induced apoptosis, ROS production, and glycative stress, likely through glyoxalase 1 up-regulation. In this study, we reported for the first time new molecular targets of sulforaphane, such as MIF, CLP36 and glyoxalase 1. In particular, we gave new insights into the anti-glycative role of sulforaphane in cardiomyocytes, confirming its pleiotropic behavior in counteracting cardiovascular diseases.

  10. Outcrop and core integrative ichnofabric analysis of Miocene sediments from Lepe, Huelva (SW Spain): Improving depositional and paleoenvironmental interpretations

    Rodríguez-Tovar, Francisco J.; Dorador, Javier; Mayoral, Eduardo; Santos, Ana


    Ichnofabric analysis was conducted in Miocene sediments from Lepe (Huelva, SW Spain) based on integrative outcrop and core research, to improve interpretations of depositional and paleoenvironmental conditions, with special attention to sequence stratigraphy. Seven intervals were differentiated in outcrops based on stratigraphic and ichnological features, consisting of two ichnofabrics: Ophiomorpha-Thalassinoides-Spongeliomorpha ichnofabric characterizes intervals 1, 2, 6, 7 and 8, while Palaeophycus-Planolites-Phycosiphon ichnofabric characterizes intervals 3, 4 and 5. Fourteen ichnofabrics were differentiated in the core, mainly in view of lithological features, including ferruginous material, grain size, mottled background, ichnotaxa, and Bioturbation Index. A comparison between outcrop and core ichnofabrics through the upper 13.5 m, corresponding to the uppermost Tortonian-lowermost Messinian interval, revealed certain similarities as well as some differences. A continuous and relatively slow siliciclastic deposition with punctual variations in the sedimentation rate can be interpreted that, associated with favorable paleoenvironmental parameters such as aerobic conditions and nutrient availability, evidence that a well-developed and diverse macroinvertebrate trace maker community existed at that time. Softgrounds are dominant, but occasionally loosegrounds and even firmgrounds could develop. The ichnofabric distribution shows long-range patterns in outcrop and core, and short-range patterns exclusively in core. Long-range patterns reflect the last phases of a transgressive system tract, with a "maximum flooding zone" at the end, and then a highstand normal regression. High-frequency, short-range, repetitive patterns in ichnofabrics from core, mainly between ichnofabrics 6/8 to 9 from lower to upper part of the pattern, can be linked to "local flooding surfaces", subdividing the "maximum flooding zone" into parasequences. Our results reveals the usefulness of

  11. Laser ablation inductively coupled plasma mass spectrometry: a new tool for trace element analysis in ice cores.

    Reinhardt, H; Kriews, M; Miller, H; Schrems, O; Lüdke, C; Hoffmann, E; Skole, J


    A new method for the detection of trace elements in polar ice cores using laser ablation with subsequent inductively coupled plasma mass spectrometry analysis is described. To enable direct analysis of frozen ice samples a special laser ablation chamber was constructed. Direct analysis reduces the risk of contamination. The defined removal of material from the ice surface by means of a laser beam leads to higher spatial resolution (300-1000 microm) in comparison to investigations with molten ice samples. This is helpful for the detection of element signatures in annual layers of ice cores. The method was applied to the successful determination of traces for the elements Mg, Al, Fe, Zn, Cd, Pb, some rare-earth elements (REE) and minor constituents such as Ca and Na in ice cores. These selected elements serve as tracer elements for certain sources and their element signatures detected in polar ice cores can give hints to climate changes in the past. We report results from measurements of frozen ice samples, the achievable signal intensities, standard deviations and calibration graphs as well as the first signal progression of 205Pb in an 8,000-year-old ice core sample from Greenland. In addition, the first picture of a crater on an ice surface burnt by an IR laser made by cryogenic scanning electron microscopy is presented.

  12. Elementary analysis of the corrosion products in the nuclear power plants` primary water; Ydinvoimalaitosveden korroosiotuotteiden alkuaineanalytiikka

    Rosenberg, R.


    The study, based on a literature survey, concentrates on the sampling and analysis methods of the dissolved or colloidal transition metals: iron, manganese, nickel and cobalt in the primary coolant waters of the nuclear power plants. (73 refs.).

  13. Optimal Design and Analysis of the Stepped Core for Wireless Power Transfer Systems

    Xiu Zhang


    Full Text Available The key of wireless power transfer technology rests on finding the most suitable means to improve the efficiency of the system. The wireless power transfer system applied in implantable medical devices can reduce the patients’ physical and economic burden because it will achieve charging in vitro. For a deep brain stimulator, in this paper, the transmitter coil is designed and optimized. According to the previous research results, the coils with ferrite core can improve the performance of the wireless power transfer system. Compared with the normal ferrite core, the stepped core can produce more uniform magnetic flux density. In this paper, the finite element method (FEM is used to analyze the system. The simulation results indicate that the core loss generated in the optimal stepped ferrite core can reduce about 10% compared with the normal ferrite core, and the efficiency of the wireless power transfer system can be increased significantly.

  14. [Analysis of core virion polypeptides from the pathogen causing chicken egg-drop syndrome].

    Iurov, G K; Dadykov, V A; Neugodova, G L; Naroditskiĭ, B S


    The cores of egg-drop syndrome virus (EDS-76) were isolated by the pyridine technique. EDS-76 proved to be much more resistant to pyridine disruption than other adenoviruses and treatment with 10% pyridine did not lead to complete dissociation of capsid and cores; only increase of pyridine concentration to 20% produced satisfactory results. At least three polypeptides (24, 10.5, and 6.5 kDa) were found in the core by SDS-PAGE, whereas the 40 kDa reacting with the core is most probably not a core component. Much more intensive reactions of the core with EDS-76 virion capsid suggest that its virion structure differs from that of other adenoviruses.

  15. Heat transfer analysis of fuel assemblies in a heterogeneous gas core nuclear rocket

    Watanabe, Yoichi; Appelbaum, Jacob; Diaz, Nils; Maya, Isaac


    Heat transfer problems of a heterogeneous gaseous core nuclear rocket were studied. The reactor core consists of 1.5-m long hexagonal fuel assemblies filled with pressurized uranium tetrafluoride (UF4) gas. The fuel gas temperature ranges from 3500 to 7000 K at a nominal operating condition of 40 atm. Each fuel assembly has seven coolant tubes, through which hydrogen propellant flows. The propellant temperature is not constrained by the fuel temperature but by the maximum temperature of the graphite coolant tube. For a core achieving a fission power density of 1000 MW/cu m, the propellant core exit temperature can be as high as 3200 K. The physical size of a 1250 MW gaseous core nuclear rocket is comparable with that of a NERVA-type solid core nuclear rocket. The engine can deliver a specific impulse of 1020 seconds and a thrust of 330 kN.

  16. Application and Analysis of Sandwich Elements in the Primary Structure of Large Wind Turbine Blades

    Berggreen, Christian; Branner, Kim; Jensen, Jacob Fisker


    is obtained. Moreover, the study showed that proper choice of core material is important to prevent face wrinkling. Geometric nonlinear analysis showed sensitivity to imperfections. A consistent submodeling technique is presented for verifying the response from the global model in any section of interest....

  17. Analysis of the Core Genome and Pan-Genome of Autotrophic Acetogenic Bacteria

    Shin, Jongoh; Song, Yoseb; Jeong, Yujin; Cho, Byung-Kwan


    Acetogens are obligate anaerobic bacteria capable of reducing carbon dioxide (CO2) to multicarbon compounds coupled to the oxidation of inorganic substrates, such as hydrogen (H2) or carbon monoxide (CO), via the Wood-Ljungdahl pathway. Owing to the metabolic capability of CO2 fixation, much attention has been focused on understanding the unique pathways associated with acetogens, particularly their metabolic coupling of CO2 fixation to energy conservation. Most known acetogens are phylogenetically and metabolically diverse bacteria present in 23 different bacterial genera. With the increased volume of available genome information, acetogenic bacterial genomes can be analyzed by comparative genome analysis. Even with the genetic diversity that exists among acetogens, the Wood-Ljungdahl pathway, a central metabolic pathway, and cofactor biosynthetic pathways are highly conserved for autotrophic growth. Additionally, comparative genome analysis revealed that most genes in the acetogen-specific core genome were associated with the Wood-Ljungdahl pathway. The conserved enzymes and those predicted as missing can provide insight into biological differences between acetogens and allow for the discovery of promising candidates for industrial applications. PMID:27733845

  18. Analysis of the core genome and pan-genome of autotrophic acetogenic bacteria

    JongOh Shin


    Full Text Available Acetogens are obligate anaerobic bacteria capable of reducing carbon dioxide (CO2 to multicarbon compounds coupled to the oxidation of inorganic substrates, such as hydrogen (H2 or carbon monoxide (CO, via the Wood-Ljungdahl pathway. Owing to the metabolic capability of CO2 fixation, much attention has been focused on understanding the unique pathways associated with acetogens, particularly their metabolic coupling of CO2 fixation to energy conservation. Most known acetogens are phylogenetically and metabolically diverse bacteria present in 23 different bacterial genera. With the increased volume of available genome information, acetogenic bacterial genomes can be analyzed by comparative genome analysis. Even with the genetic diversity that exists among acetogens, the Wood-Ljungdahl pathway, a central metabolic pathway, and cofactor biosynthetic pathways are highly conserved for autotrophic growth. Additionally, comparative genome analysis revealed that most genes in the acetogen-specific core genome were associated with the Wood-Ljungdahl pathway. The conserved enzymes and those predicted as missing can provide insight into biological differences between acetogens and allow for the discovery of promising candidates for industrial applications.

  19. Continuous flow analysis method for determination of soluble iron and aluminium in ice cores.

    Spolaor, A; Vallelonga, P; Gabrieli, J; Roman, M; Barbante, C


    Iron and aluminium are the two most abundant metals on the Earth's crust, but they display quite different biogeochemical properties. While iron is essential to many biological processes, aluminium has not been found to have any biological function at all. In environmental studies, iron has been studied in detail for its limiting role in the bioproductivity of high nutrient, low carbon oceanic zones, while aluminium is routinely used as a reference of crustal contributions to atmospheric deposition archives including peat bogs, lacustrine and marine sediments and ice sheets and glaciers. We report here the development of a flow injection analysis technique, which has been optimised for the simultaneous determination of soluble iron and aluminium in polar ice cores. Iron was determined by its catalytic role in the reduction of N,N-dimethyl-p-phenylenediamene (DPD) to a semiquinonic form (DPDQ) and subsequent absorption spectroscopy at 514 nm. Aluminium was determined by spectroscopic analysis of an aluminium-lumogallion complex that exhibits fluorescence at 560 nm. These techniques have been applied to a section of Greenland ice dated to 1729-1733 AD and indicate that volcanism is a source of highly soluble aluminium and iron.

  20. Feeling of 'lacking' as the core of envy: a conceptual analysis of envy.

    Maijala, H; Munnukka, T; Nikkonen, M


    The aim of this paper is to explore the subjective experience of envy through concept analysis. Further, the study on which it is based aimed to answer questions about the composition and manifestations of envy. From the viewpoint of nursing science, the analysis of envy is based on a desire to understand human beings from the perspective of subjective health and illness and thus from a health promotion perspective. Envy is conceived of as a dimension of a person's health and illness. The concept is therefore meaningful from the viewpoint of nursing; it describes a phenomenon which enables us to deepen our understanding in a way relevant to nursing science. In the study the hybrid model developed by Schwartz-Barcott et al. was used for conceptual elaboration. In the theoretical phase of the study the subjective experience of envy was explored from the viewpoints of philosophy, religion, Finnish folklore and psychoanalysis, as well as nursing science. As a synthesis of these, a conceptual analysis of envy adapted from Wilson was conducted and a working definition of envy was proposed. In the fieldwork phase, envy was examined by means of an empirical analysis using a phenomenological approach. As a result, a classification describing the experience of envy was presented. The core experience of envy has been defined as a 'lacking', and the object of envy as something good possessed by someone else. Envy manifests itself in both destructiveness and creativity. The trends of development of envy are inflexibility and emancipation, and the essence of envy is multidimensional. Finally, the working definition of the concept was elaborated on the basis of the empirical phase and a new definition reflecting the composition and manifestations of envy was proposed.

  1. Flow Dynamic Analysis of Core Shooting Process through Experiment and Multiphase Modeling

    Changjiang Ni


    Full Text Available Core shooting process is the most widely used technique to make sand cores and it plays an important role in the quality of sand cores as well as the manufacture of complicated castings in metal casting industry. In this paper, the flow behavior of sand particles in the core box was investigated synchronously with transparent core box, high-speed camera, and pressure measuring system. The flow pattern of sand particles in the shooting head of the core shooting machine was reproduced with various colored core sand layers. Taking both kinetic and frictional stress into account, a kinetic-frictional constitutive correlation was established to describe the internal momentum transfer in the solid phase. Two-fluid model (TFM simulations with turbulence model were then performed and good agreement was achieved between the experimental and simulation results on the flow behavior of sand particles in both the shooting head and the core box. Based on the experimental and simulation results, the flow behavior of sand particles in the core box, the formation of “dead zone” in the shooting head, and the effect of drag force were analyzed in terms of sand volume fraction (αs, sand velocity (Vs, and pressure variation (P.

  2. Analysis of suspended solids transport processes in primary settling tanks.

    Patziger, Miklós; Kiss, Katalin


    The paper shows the results of a long-term research comprising FLUENT-based numerical modeling, in situ measurements and laboratory tests to analyze suspended solids (SS) transport processes in primary settling tanks (PSTs). The investigated PST was one of the rectangular horizontal flow PSTs at a large municipal wastewater treatment plant (WWTP) of a capacity of 500,000 population equivalent. Many middle-sized and large WWTPs are equipped with such PSTs. The numerical PST model was calibrated and validated based on the results of comprehensive in situ flow and SS concentration measurements from low (5 m/h) up to quite high surface overflow rates of 9.5 and 13.0 m/h and on settling and other laboratory tests. The calibrated and validated PST model was also successfully used for evaluation of some slight modifications of the inlet geometry (removing lamellas, installing a flocculation 'box', shifting the inlet into a 'bottom-near' or into a 'high' position), which largely affect PST behavior and performance. The investigations provided detailed insight into the flow and SS transport processes within the investigated PST, which strongly contributes to hydrodynamically driven design and upgrading of PSTs.

  3. Mutational analysis of primary central nervous system lymphoma.

    Bruno, Aurélie; Boisselier, Blandine; Labreche, Karim; Marie, Yannick; Polivka, Marc; Jouvet, Anne; Adam, Clovis; Figarella-Branger, Dominique; Miquel, Catherine; Eimer, Sandrine; Houillier, Caroline; Soussain, Carole; Mokhtari, Karima; Daveau, Romain; Hoang-Xuan, Khê


    Little is known about the genomic basis of primary central nervous system lymphoma (PCNSL) tumorigenesis. To investigate the mutational profile of PCNSL, we analyzed nine paired tumor and germline DNA samples from PCNSL patients by high throughput exome sequencing. Eight genes of interest have been further investigated by focused resequencing in 28 additional PCNSL tumors to better estimate their incidence. Our study identified recurrent somatic mutations in 37 genes, some involved in key signaling pathways such as NFKB, B cell differentiation and cell cycle control. Focused resequencing in the larger cohort revealed high mutation rates for genes already described as mutated in PCNSL such as MYD88 (38%), CD79B (30%), PIM1 (22%) and TBL1XR1 (19%) and for genes not previously reported to be involved in PCNSL tumorigenesis such as ETV6 (16%), IRF4 (14%), IRF2BP2 (11%) and EBF1 (11%). Of note, only 3 somatically acquired SNVs were annotated in the COSMIC database. Our results demonstrate a high genetic heterogeneity of PCNSL and mutational pattern similarities with extracerebral diffuse large B cell lymphomas, particularly of the activated B-cell (ABC) subtype, suggesting shared underlying biological mechanisms. The present study provides new insights into the mutational profile of PCNSL and potential targets for therapeutic strategies.

  4. Design and analysis of a toroidal tester for the measurement of core losses under axial compressive stress

    Alatawneh, Natheer; Rahman, Tanvir; Lowther, David A.; Chromik, Richard


    Electric machine cores are subjected to mechanical stresses due to manufacturing processes. These stresses include radial, circumferential and axial components that may have significant influences on the magnetic properties of the electrical steel and hence, on the output and efficiencies of electrical machines. Previously, most studies of iron losses due to mechanical stress have considered only radial and circumferential components. In this work, an improved toroidal tester has been designed and developed to measure the core losses and the magnetic properties of electrical steel under a compressive axial stress. The shape of the toroidal ring has been verified using 3D stress analysis. Also, 3D electromagnetic simulations show a uniform flux density distribution in the specimen with a variation of 0.03 T and a maximum average induction level of 1.5 T. The developed design has been prototyped, and measurements were carried out using a steel sample of grade 35WW300. Measurements show that applying small mechanical stresses normal to the sample thickness rises the delivered core losses, then the losses decrease continuously as the stress increases. However, the drop in core losses at high stresses does not go lower than the free-stress condition. Physical explanations for the observed trend of core losses as a function of stress are provided based on core loss separation to the hysteresis and eddy current loss components. The experimental results show that the effect of axial compressive stress on magnetic properties of electrical steel at high level of inductions becomes less pronounced.

  5. Analysis of core damage frequency due to external events at the DOE (Department of Energy) N-Reactor

    Lambright, J.A.; Bohn, M.P.; Daniel, S.L. (Sandia National Labs., Albuquerque, NM (USA)); Baxter, J.T. (Westinghouse Hanford Co., Richland, WA (USA)); Johnson, J.J.; Ravindra, M.K.; Hashimoto, P.O.; Mraz, M.J.; Tong, W.H.; Conoscente, J.P. (EQE, Inc., San Francisco, CA (USA)); Brosseau, D.A. (ERCE, Inc., Albuquerque, NM (USA))


    A complete external events probabilistic risk assessment has been performed for the N-Reactor power plant, making full use of all insights gained during the past ten years' developments in risk assessment methodologies. A detailed screening analysis was performed which showed that all external events had negligible contribution to core damage frequency except fires, seismic events, and external flooding. A limited scope analysis of the external flooding risk indicated that it is not a major risk contributor. Detailed analyses of the fire and seismic risks resulted in total (mean) core damage frequencies of 1.96E-5 and 4.60E-05 per reactor year, respectively. Detailed uncertainty analyses were performed for both fire and seismic risks. These results show that the core damage frequency profile for these events is comparable to that found for existing commercial power plants if proposed fixes are completed as part of the restart program. 108 refs., 85 figs., 80 tabs.

  6. Analysis of Chinese women with primary ovarian insufficiency by high resolution array-comparative genomic hybridization

    LIAO Can; FU Fang; YANG Xin; SUN Yi-min; LI Dong-zhi


    Background Primary ovarian insufficiency (POI) is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 years. The etiology of primary ovarian insufficiency in human female patients is still unclear. The purpose of this study is to investigate the potential genetic causes in primary amenorrhea patients by high resolution array based comparative genomic hybridization (array-CGH) analysis.Methods Following the standard karyotyping analysis, genomic DNA from whole blood of 15 primary amenorrhea patients and 15 normal control women was hybridized with Affymetrix cytogenetic 2.7M arrays following the standard protocol. Copy number variations identified by array-CGH were confirmed by real time polymerase chain reaction.Results All the 30 samples were negative by conventional karyotyping analysis. Microdeletions on chromosome 17q21.31-q21.32 with approximately 1.3 Mb were identified in four patients by high resolution array-CGH analysis. This included the female reproductive secretory pathway related factor N-ethylmaleimide-sensitive factor (NSF) gene.Conclusions The results of the present study suggest that there may be critical regions regulating primary ovarian insufficiency in women with a 17q21.31-q21.32 microdeletion. This effect might be due to the loss of function of the NSF gene/genes within the deleted region or to effects on contiguous genes.

  7. Primary seminal vesicle carcinoma: an immunohistochemical analysis of four cases.

    Ormsby, A H; Haskell, R; Jones, D; Goldblum, J R


    Primary adenocarcinoma of the seminal vesicles is an extremely rare neoplasm. Because prompt diagnosis and treatment are associated with improved long-term survival, accurate recognition of this neoplasm is important, particularly when evaluating limited biopsy material. Immunohistochemistry can be used to rule out neoplasms that commonly invade the seminal vesicles, such as prostatic adenocarcinoma. Previous reports have shown that seminal vesicle adenocarcinoma (SVCA) is negative for prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PAP); however, little else is known of its immunophenotype. Consequently, we evaluated the utility of cancer antigen 125 (CA-125) and cytokeratin (CK) subsets 7 and 20 for distinguishing SVCA from other neoplasms that enter the differential diagnosis. Four cases of SVCA-three cases of bladder adenocarcinoma and a rare case of adenocarcinoma arising in a mullerian duct cyst-were immunostained for CA-125, CK7, and CK20. Three of four cases of SVCA were CA-125 positive and CK7 positive. All four cases were CK20 negative. All bladder adenocarcinomas and the mullerian duct cyst adenocarcinoma were CK7 positive and negative for CA-125 and CK20. In addition, CA-125 immunostaining was performed in neoplasms that commonly invade the seminal vesicles, including prostatic adenocarcinoma (n = 40), bladder transitional cell carcinoma (n = 32), and rectal adenocarcinoma (n = 10), and all were negative for this antigen. In conclusion, the present study has shown that the CK7-positive, CK20-negative, CA-125-positive, PSA/PAP-negative immunophenotype of papillary SVCA is unique and can be used in conjunction with histomorphology to distinguish it from other tumors that enter the differential diagnosis, including prostatic adenocarcinoma (CA-125 negative, PSA/PAP positive), bladder transitional cell carcinoma (CK20 positive, CA-125 negative), rectal adenocarcinoma (CA-125 negative, CK7 negative, CK20 positive), bladder

  8. An Analysis of Anthropometric Data on Iranian Primary School Children

    R Hafezi


    Full Text Available "nBackground: Anthropometric data can be used to identify the physical dimensions of equipment, furniture, etc. The use of furni­ture that fails to fulfill the anthropometric data of its users has a negative impact on human health. Specific anthropomet­ric dimensions are necessary to design school furniture. Anthropometric data have been measured in many communi­ties especially among schoolchildren. There are different ethnic groups with probably different anthropometric data in Iran, and anthropometric data can change by time, so gathering data about anthropometric dimensions is important. This study was designed to obtain anthropometric dimensions of Iranian children (Fars ethnicity aged 7-11 years. "nMethods: In a cross-sectional study in Yazd, Iran, descriptive statistics as well as key percentiles for 17 static anthropomet­ric data of primary school students (1015 males and 1015 females, were measured and compared between boys and girls. "nResults: The age of the students was between 6 and 11 years. Mean weight was between 21.56±5.33 kg and 36.63±9.45 kg in boys and between 20.79±3.48 kg and 35.88±9.40 kg in girls. Mean height was between 1187/02±53.98 mm and 1420.83± 69.39 mm in boys and between 1173.90±51.01mm and 1421.27±70.82 mm in girls. There was also some differ­ence in other anthropometric data between two genders. "nConclusion: Results of this study showed some differences in anthropometric data with other studies. We also observed signifi­cant gender differences in some dimensions as well. 

  9. Microstructural analysis of demineralized primary enamel after in vitro toothbrushing

    Neves Aline de Almeida


    Full Text Available The aim of this study was to investigate, in vitro, the morphological characteristics of demineralized primary enamel subjected to brushing with a dentifrice with or without fluoride. In order to do so, 32 enamel blocks were divided in 4 different groups containing 8 blocks each. They were separately immersed in artificial saliva for 15 days. The experimental groups were: C - control; E - submitted to etching with 37% phosphoric acid gel (30 s; EB - submitted to etching and brushing 3 times a day with a non-fluoridated dentifrice; EBF = submitted to etching and brushing 3 times a day with a fluoridated dentifrice. The toothbrushing force was standardized at 0.2 kgf and 15 double strokes were performed on each block. After the experimental period, the samples were prepared and examined under SEM. The control group (C showed a smooth surface, presenting scratches caused by habitual toothbrushing. The etched samples (E exhibited different degrees of surface disintegration, but the pattern of acid etching was predominantly the type II dissolution. The brushed surfaces were smooth, with elevations which corresponded to the exposure of Tomes? process pits and depressions which corresponded to interrod enamel. Particles resembling calcium carbonate were found in the most protected parts of the grooves. No morphological differences were observed between brushing with fluoridated (EBF and non-fluoridated (EB dentifrice. The results suggest that the mechanical abrasion caused by brushing demineralized enamel with dentifrice smoothes the rough etched surface, and the presence of fluoride does not cause morphological modifications in this pattern.

  10. Core gene set as the basis of multilocus sequence analysis of the subclass Actinobacteridae.

    Toïdi Adékambi

    Full Text Available Comparative genomic sequencing is shedding new light on bacterial identification, taxonomy and phylogeny. An in silico assessment of a core gene set necessary for cellular functioning was made to determine a consensus set of genes that would be useful for the identification, taxonomy and phylogeny of the species belonging to the subclass Actinobacteridae which contained two orders Actinomycetales and Bifidobacteriales. The subclass Actinobacteridae comprised about 85% of the actinobacteria families. The following recommended criteria were used to establish a comprehensive gene set; the gene should (i be long enough to contain phylogenetically useful information, (ii not be subject to horizontal gene transfer, (iii be a single copy (iv have at least two regions sufficiently conserved that allow the design of amplification and sequencing primers and (v predict whole-genome relationships. We applied these constraints to 50 different Actinobacteridae genomes and made 1,224 pairwise comparisons of the genome conserved regions and gene fragments obtained by using Sequence VARiability Analysis Program (SVARAP, which allow designing the primers. Following a comparative statistical modeling phase, 3 gene fragments were selected, ychF, rpoB, and secY with R2>0.85. Selected sets of broad range primers were tested from the 3 gene fragments and were demonstrated to be useful for amplification and sequencing of 25 species belonging to 9 genera of Actinobacteridae. The intraspecies similarities were 96.3-100% for ychF, 97.8-100% for rpoB and 96.9-100% for secY among 73 strains belonging to 15 species of the subclass Actinobacteridae compare to 99.4-100% for 16S rRNA. The phylogenetic topology obtained from the combined datasets ychF+rpoB+secY was globally similar to that inferred from the 16S rRNA but with higher confidence. It was concluded that multi-locus sequence analysis using core gene set might represent the first consensus and valid approach for

  11. Homeless people's access to primary care physiotherapy services: an exploratory, mixed-method investigation using a follow-up qualitative extension to core quantitative research.

    Dawes, Jo; Deaton, Stuart; Greenwood, Nan


    The purpose of this study was to appraise referrals of homeless patients to physiotherapy services and explore perceptions of barriers to access. This exploratory mixed-method study used a follow-up qualitative extension to core quantitative research design. Over 9 months, quantitative data were gathered from the healthcare records of homeless patients referred to physiotherapy by a general practitioner (GP) practice, including the number of referrals and demographic data of all homeless patients referred. Corresponding physiotherapy records of those people referred to physiotherapy were searched for the outcome of their care. Qualitative semi-structured telephone interviews, based on the quantitative findings, were carried out with staff involved with patient care from the referring GP practice and were used to expand insight into the quantitative findings. Two primary care sites provided data for this study: a GP practice dedicated exclusively to homeless people and the physiotherapy department receiving their referrals. Quantitative data from the healthcare records of 34 homeless patient referrals to physiotherapy were collected and analysed. In addition, five staff involved in patient care were interviewed. 34 referrals of homeless people were made to physiotherapy in a 9-month period. It was possible to match 25 of these to records from the physiotherapy department. Nine (36%) patients did not attend their first appointment; seven (28%) attended an initial appointment, but did not attend a subsequent appointment and were discharged from the service; five (20%) completed treatment and four patients (16%) had ongoing treatment. Semi-structured interviews revealed potential barriers preventing homeless people from accessing physiotherapy services, the complex factors being faced by those making referrals and possible ways to improve physiotherapy access. Homeless people with musculoskeletal problems may fail to access physiotherapy treatment, but opportunities

  12. Sensitivity Analysis of Core Damage from Reactor Coolant Pump Seal Leakage during Extended Loss of All AC Power

    Park, Da Hee; Kim, Min Gi; Lee, Kyung Jin; Hwang, Su hyun; Lee, Byung Chul [FNC Technology Co. Ltd., Yongin (Korea, Republic of); Yoon, Duk Joo; Lee, Seung Chan [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)


    In this study, in order to comprehend the Fukushima accident, the sensitivity analysis was performed to analyze the behavior of Reactor Coolant System (RCS) during ELAP using the RELAP5/MOD3.3 code. The Fukushima accident was caused by tsunami resulted in Station Black Out (SBO) followed by the reactor core melt-down and release of radioactive materials. After the accident, the equipment and strategies for the Extended Loss of All AC Power (ELAP) were recommended strongly. In this analysis, sensitivity studies for the RCP seal failure of the OPR1000 type NPP were performed by using RELAP5/MOD3.3 code. Six cases with different leakage rate of RCP seal were studied for ELAP with operator action or not. The main findings are summarized as follows: (1) Without the operator action, the core uncovery time is determined by the leakage rate of RCP seal. When the leakage rate per RCP seal are 5 gpm, 50 gpm, and 300 gpm respectively, the core uncovery time are 1.62 hr, 1.58 hr, and 1.29 hr respectively. Namely, If the leakage rate of RCP seal was much bigger, the uncover time of core would be shorter. (2) In case that the cooling by SG secondary side was performed using the TDAFP and SG ADV, the core uncovery time was significantly extended.

  13. Processing and geologic analysis of conventional cores from well ER-20-6 No. 1, Nevada Test Site

    Prothro, L.B., Townsend, M.J.; Drellack, S.L. Jr. [and others


    In 1996, Well Cluster ER-20-6 was drilled on Pahute Mesa in Area 20, in the northwestern corner of the Nevada Test Site (NTS). The three wells of the cluster are located from 166 to 296 meters (m) (544 to 971 feet [ft]) southwest of the site of the underground nuclear test code-named BULLION, conducted in 1990 in Emplacement Hole U-20bd. The well cluster was planned to be the site of a forced-gradient experiment designed to investigate radionuclide transport in groundwater. To obtain additional information on the occurrence of radionuclides, nature of fractures, and lithology, a portion of Well ER-20-6 No. 1, the hole closest to the explosion cavity, was cored for later analysis. Bechtel Nevada (BN) geologists originally prepared the geologic interpretation of the Well Cluster ER-20-6 site and documented the geology of each well in the cluster. However, the cores from Well ER-20-6 No. 1 were not accessible at the time of that work. As the forced-gradient experiment and other radio nuclide migration studies associated with the well cluster progressed, it was deemed appropriate to open the cores, describe the geology, and re-package the core for long-term air-tight storage. This report documents and describes the processing, geologic analysis, and preservation of the conventional cores from Well ER20-6 No. 1.

  14. Metatranscriptomic analysis of diverse microbial communities reveals core metabolic pathways and microbiome-specific functionality.

    Jiang, Yue; Xiong, Xuejian; Danska, Jayne; Parkinson, John


    Metatranscriptomics is emerging as a powerful technology for the functional characterization of complex microbial communities (microbiomes). Use of unbiased RNA-sequencing can reveal both the taxonomic composition and active biochemical functions of a complex microbial community. However, the lack of established reference genomes, computational tools and pipelines make analysis and interpretation of these datasets challenging. Systematic studies that compare data across microbiomes are needed to demonstrate the ability of such pipelines to deliver biologically meaningful insights on microbiome function. Here, we apply a standardized analytical pipeline to perform a comparative analysis of metatranscriptomic data from diverse microbial communities derived from mouse large intestine, cow rumen, kimchi culture, deep-sea thermal vent and permafrost. Sequence similarity searches allowed annotation of 19 to 76% of putative messenger RNA (mRNA) reads, with the highest frequency in the kimchi dataset due to its relatively low complexity and availability of closely related reference genomes. Metatranscriptomic datasets exhibited distinct taxonomic and functional signatures. From a metabolic perspective, we identified a common core of enzymes involved in amino acid, energy and nucleotide metabolism and also identified microbiome-specific pathways such as phosphonate metabolism (deep sea) and glycan degradation pathways (cow rumen). Integrating taxonomic and functional annotations within a novel visualization framework revealed the contribution of different taxa to metabolic pathways, allowing the identification of taxa that contribute unique functions. The application of a single, standard pipeline confirms that the rich taxonomic and functional diversity observed across microbiomes is not simply an artefact of different analysis pipelines but instead reflects distinct environmental influences. At the same time, our findings show how microbiome complexity and availability of

  15. Residual dent in locally loaded foam core sandwich structures – Analysis and use for NDI

    Koysin, V.; Shipsha, Andrey


    This paper addresses the residual denting in the face sheet and corresponding core damage in a locally loaded flat sandwich structure with foam core. The problem is analytically considered in the context of elastic bending of the face sheet accompanied by non-linear deformation of the crushed foam

  16. Variation in plasma calcium analysis in primary care in Sweden - a multilevel analysis

    Eggertsen Robert


    Full Text Available Abstract Background Primary hyperparathyroidism (pHPT is a common disease that often remains undetected and causes severe disturbance especially in postmenopausal women. Therefore, national recommendations promoting early pHPT detection by plasma calcium (P-Ca have been issued in Sweden. In this study we aimed to investigate variation of P-Ca analysis between physicians and health care centres (HCCs in primary care in county of Skaraborg, Sweden. Methods In this cross sectional study of patients' records during 2005 we analysed records from 154 629 patients attending 457 physicians at 24 HCCs. We used multilevel logistic regression analysis (MLRA and adjusted for patient, physician and HCC characteristics. Differences were expressed as median odds ratio (MOR. Results There was a substantial variation in number of P-Ca analyses between both HCCs (MORHCC 1.65 [1.44-2.07] and physicians (MORphysician 1.95 [1.85-2.08]. The odds for a P-Ca analysis were lower for male patients (OR 0.80 [0.77-0.83] and increased with the number of diagnoses (OR 25.8 [23.5-28.5]. Sex of the physician had no influence on P-Ca test ordering (OR 0.93 [0.78-1.09]. Physicians under education ordered most P-Ca analyses (OR 1.69 [1.35-2.24] and locum least (OR 0.73 [0.57-0.94]. More of the variance was attributed to the physician level than the HCC level. Different mix of patients did not explain this variance between physicians. Theoretically, if a patient were able to change both GP and HCC, the odds of a P-Ca analysis would in median increase by 2.45. Including characteristics of the patients, physicians and HCCs in the MLRA model did not explain the variance. Conclusions The physician level was more important than the HCC level for the variation in P-Ca analysis, but further exploration of unidentified contextual factors is crucial for future monitoring of practice variation.

  17. The study on the core personality trait words of Chinese medical university students based on social network analysis.

    Wu, Ying; Xue, Yunzhen; Xue, Zhanling


    The medical university students in China whose school work is relatively heavy and educational system is long are a special professional group. Many students have psychological problems more or less. So, to understand their personality characteristics will provide a scientific basis for the intervention of psychological health.We selected top 30 personality trait words according to the order of frequency. Additionally, some methods such as social network analysis (SNA) and visualization technology of mapping knowledge domain were used in this study.Among these core personality trait words Family conscious had the 3 highest centralities and possessed the largest core status and influence. From the analysis of core-peripheral structure, we can see polarized core-perpheral structure was quite obvious. From the analysis of K-plex, there were in total 588 "K-2"K-plexs. From the analysis of Principal Components, we selected the 11 principal components.This study of personality not only can prevent disease, but also provide a scientific basis for students' psychological healthy education. In addition, we have adopted SNA to pay more attention to the relationship between personality trait words and the connection among personality dimensions. This study may provide the new ideas and methods for the research of personality structure.

  18. Exploitation of chemical profiles by conjugate variable analysis: application to the dating of a tropical ice core (Nevado Illimani, Bolivia)

    Gay, M.; De Angelis, M.; Lacoume, J.-L.


    Ice core dating is a key parameter for the interpretation of the ice archives. However, the relationship between ice depth and age can generally not be easily established and requires to combine a large number of investigations and/or modeling effort. This paper presents a new approach of ice core dating based on conjugate variable (depth and spatial frequency) analysis of chemical profiles. The relationship between the depth of a given ice layer and the date it was deposited is determined using ion concentration depth profiles obtained along a one hundred-meters deep ice core recovered in the summit area of the Nevado Illimani (6350 m a.s.l.), located in the Eastern Bolivian Andes (16°37' S, 67°46' W). The results of Fourier conjugate analysis and wavelet tranforms are first compared. Both methods are applied to nitrate concentration depth profile. The resulting chronologies are checked by comparison with the multi-proxy year-by-year dating published by de Angelis et al. (2003) and with volcanic tie points, demonstrating the efficiency of Fourier conjugate analysis when tracking the natural variability of chemical proxies. The Fourier conjugate analysis is then applied to concentration depth profiles of seven other ions thus providing information on the suitability of each of them for dating studies of tropical Andean ice cores.

  19. An Analysis of the Alignment of the Grade 12 Physical Sciences Examination and the Core Curriculum in South Africa

    Edwards, Nazeem


    I report on an analysis of the alignment between the South African Grade 12 Physical Sciences core curriculum content and the exemplar papers of 2008, and the final examination papers of 2008 and 2009. A two-dimensional table was used for both the curriculum and the examination in order to calculate the Porter alignment index, which indicates the…

  20. Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B.

    Lee, Jong Ho; Hong, Sun Pyo; Jang, Eun Sun; Park, Sang Jong; Hwang, Seong Gyu; Kang, Sook-Kyoung; Jeong, Sook-Hyang


    Acute hepatitis B, caused by hepatitis B virus (HBV) strains with drug resistant mutations or pre-core/basal core promoter (PC/BCP) mutations, is a public health concern, because this infection is often associated with poor disease outcome or difficulty in therapeutic choice. The HBV genotype, the prevalence of drug resistant mutations, and PC/BCP mutations in Korean patients with acute hepatitis B were studied. From 2006 to 2008, 36 patients with acute hepatitis B were enrolled prospectively in four general hospitals. Among them, 20 showed detectable HBV DNA (median value was 4.8 log copies/mL). HBV genotyping and analysis of HBV mutations that conferred resistance against lamivudine, adefovir, or entecavir and of PC/BCP mutations were performed using highly sensitive restriction fragment mass polymorphism (RFMP) analysis. All 20 patients were infected with HBV genotype C, which causes almost all cases of chronic hepatitis B in Korea. No patient showed mutations that conferred resistance against lamivudine (L180M, M204V/I), adefovir (A181T, N236S), or entecavir (I169M, A184T/V, S202I/G, M250V/I/L). However, four patients had BCP mutations, and two had PC mutations. Platelet counts were significantly lower in the four patients with PC/BCP mutations compared to those with wild type. In this study, all acute hepatitis B patients had genotype C HBV strains with no drug resistant mutations. However, 20% showed PC/BCP mutations. This highlights the need for further study on the significance of PC/BCP mutations.

  1. [Culture medium optimization and primary kinetics analysis for nisin production].

    Li, C; Bai, J H; Cai, Z L; Ouyang, F


    Response surface methodology was used to optimize a medium for nisin production of Lactococcus lactis. In the first optimization step the influence of sucrose, soybean peptone, yeast extract, potassium dihydrogen phosphate, sodium chloride, and magnesium sulfur on nisin production was evaluated using a fractional factorial design. Potassium dihydrogen phosphate influenced nisin production positively while soybean peptone affected nisin production negatively. The other components had no significant effect on nisin production. The path of steepest ascent was used to approach the optimal region of the medium composition. In the third step the optimal concentrations of KH2PO4 and soybean peptone were determined by a central composite design and response surface analysis. The optimized medium allowed nisin production to be increased from 1074 IU/mL to 2150 IU/mL. The kinetic analysis showed that nisin production fashion at optimized and non-optimized media was not changed and maintained partially growth-associated. But the specific growth rates and the specific nisin production rates for the strain at the optimized medium were bigger than the ones at the non-optimized medium after the cells entered the middle of exponential phase.

  2. Design and analysis of nanowire p-type MOSFET coaxially having silicon core and germanium peripheral channel

    Yu, Eunseon; Cho, Seongjae


    In this work, a nanowire p-type metal-oxide-semiconductor field-effect transistor (PMOSFET) coaxially having a Si core and a Ge peripheral channel is designed and characterized by device simulations. Owing to the high hole mobility of Ge, the device can be utilized for high-speed CMOS integrated circuits, with the effective confinement of mobile holes in Ge by the large valence band offset between Si and Ge. Source/drain doping concentrations and the ratio between the Si core and Ge channel thicknesses are determined. On the basis of the design results, the channel length is aggressively scaled down by evaluating the primary DC parameters in order to confirm device scalability and low-power applicability in sub-10-nm technology nodes.

  3. Citation analysis did not provide a reliable assessment of core outcome set uptake.

    Barnes, Karen L; Kirkham, Jamie J; Clarke, Mike; Williamson, Paula R


    The aim of the study was to evaluate citation analysis as an approach to measuring core outcome set (COS) uptake, by assessing whether the number of citations for a COS report could be used as a surrogate measure of uptake of the COS by clinical trialists. Citation data were obtained for COS reports published before 2010 in five disease areas (systemic sclerosis, rheumatoid arthritis, eczema, sepsis and critical care, and female sexual dysfunction). Those publications identified as a report of a clinical trial were examined to identify whether or not all outcomes in the COS were measured in the trial. Clinical trials measuring the relevant COS made up a small proportion of the total number of citations for COS reports. Not all trials citing a COS report measured all the recommended outcomes. Some trials cited the COS reports for other reasons, including the definition of a condition or other trial design issues addressed by the COS report. Although citation data can be readily accessed, it should not be assumed that the citing of a COS report indicates that a trial has measured the recommended COS. Alternative methods for assessing COS uptake are needed. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  4. A quantitative analysis of the reactions involved in stratospheric ozone depletion in the polar vortex core

    I. Wohltmann


    Full Text Available We present a quantitative analysis of the chemical reactions involved in polar ozone depletion in the stratosphere and of the relevant reaction pathways and cycles. While the reactions involved in polar ozone depletion are well known, quantitative estimates of the importance of individual reactions or reaction cycles are rare. In particular, there is no comprehensive and quantitative study of the reaction rates and cycles averaged over the polar vortex under conditions of heterogeneous chemistry so far. We show time series of reaction rates averaged over the core of the polar vortex in winter and spring for all relevant reactions and indicate which reaction pathways and cycles are responsible for the vortex-averaged net change of the key species involved in ozone depletion, i.e., ozone, chlorine species (ClOx, HCl, ClONO2, bromine species, nitrogen species (HNO3, NOx and hydrogen species (HOx. For clarity, we focus on one Arctic winter (2004–2005 and one Antarctic winter (2006 in a layer in the lower stratosphere around 54 hPa and show results for additional pressure levels and winters in the Supplement. Mixing ratios and reaction rates are obtained from runs of the ATLAS Lagrangian chemistry and transport model (CTM driven by the European Centre for Medium-Range Weather Forecasts (ECMWF ERA-Interim reanalysis data. An emphasis is put on the partitioning of the relevant chemical families (nitrogen, hydrogen, chlorine, bromine and odd oxygen and activation and deactivation of chlorine.

  5. Shock Revival in Core-Collapse Supernovae: A Phase-Diagram Analysis

    Gabay, Daniel; Keshet, Uri


    We examine the conditions for the revival of the stalled accretion shock in core-collapse supernovae, in the context of the neutrino heating mechanism. We combine one dimensional simulations of the shock revival process with a derivation of a quasi-stationary approximation, which is both accurate and efficient in predicting the flow. In particular, this approach is used to explore how the evolution of the system depends on the shock radius, $R_S$, and velocity, $V_S$ (in addition to other global properties of the system). We do so through a phase space analysis of the shock acceleration, $a_S$, in the $R_S-V_S$ plane, shown to provide quantitative insights into the initiation of runaway expansion and its nature. In the particular case of an initially stationary ($V_S=0,\\;a_S=0$) profile, the prospects for an explosion can be reasonably assessed by the initial signs of the partial derivatives of the shock acceleration, in analogy to a linear damped/anti-damped oscillator. If $\\partial a_S/\\partial R_S0$, runaw...

  6. An empirical analysis of the required management skills in the core employees' identification

    Natalia García Carbonell


    Full Text Available The current study empirically analyses the influence of top management team human capital attributes on one of the most relevant stages in the human resource management strategy formulation: the core employees' identification. Drawing on recent calls from the strategic human resource management literature, this study proposes a "process" perspective instead of the traditional "content" analysis, with the intention of going a step further on the internal dynamic of these strategic processes. Applying the structural equation modeling via Partial Least Square (PLS on a sample of 120 Spanish firms, results reveal that critical human resources identification processes demand mixed cognitive skills, rational and creative ones, in order to complete efficiently different steps of the process. Consequently, to reach a balanced combination of previous skills, collectivistic dynamics are needed, fostering cooperative and collaborative decision making processes. In this context, HR managers will participate improving the process with his/her expert power and developing technical HR activities; subsequently, the HR information will be integrated the strategic decision making process with the rest of the team. In addition, interesting professional implications arise from the study in relation to the presence of the cognitive diversity in top management teams.

  7. Rasch analysis of the postconcussive symptom questionnaire: measuring the core construct of brain injury symptomatology.

    Gardizi, Elmar; Millis, Scott R; Hanks, Robin; Axelrod, Bradley


    The Postconcussive Symptom Questionnaire (PCSQ; Lees-Haley, 1992 ) is purported to measure four constructs. These include psychological, cognitive, somatic, and infrequency (i.e., items intended to reflect negative impression management) symptoms. The utility and validity of Postconcussive Syndrome (PCS) as a diagnostic condition continues to be debated. To this end, examining the instruments used to measure postconcussive symptoms can increase our understanding with respect to this issue. The aim of this study was to derive a revised PCSQ to target the core construct of subjective symptoms reported by persons with traumatic brain injury (TBI). A total of 133 people with mild to severe TBI completed the 45-item PCSQ. Items were scored dichotomously, as symptom present or absent. Rasch analysis, based on the mathematical model formulated by Rasch ( 1960 ), was used to derive the revised PCSQ. Misfitting and redundant items were removed and a second model containing 19 items was fitted. The revised PCSQ-19 had superior psychometric qualities; reliability was 0.81. The PCSQ-19 provides a more targeted, unidimensional assessment of subjective symptoms following brain injury. The findings also revealed information related to symptom hierarchy which can further our understanding of PCS.

  8. Metabolome analysis - mass spectrometry and microbial primary metabolites

    Højer-Pedersen, Jesper Juul


    that are highly sensitive and specific, and to undertake this challenge mass spectrometry (MS) is among the best candidates. Along with analysis of the metabolome the research area of metabolomics has evolved. Metabolomics combines metabolite profiles, data mining and biochemistry and aims at understanding...... the interplay between metabolites. In this thesis, different topics have been addressed and discussed with the aim of advancing metabolomics to explore the concept in a physiological context. The metabolome comprises a wide variety of chemical compounds that act differently upon sample preparation...... glucose, galactose or ethanol, and metabolic footprinting by mass spectrometry was used to study the influence of carbon source on the extracellular metabolites. The results showed that footprints clustered according to the carbon source. Advances in technologies for analytical chemistry have mediated...

  9. Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

    Zhao, Xiaozheng; Huffman, Kenneth E.; Fujimoto, Junya; Canales, Jamie Rodriguez; Girard, Luc; Nie, Guangjun; Heymach, John V.; Wistuba, Igacio I.; Minna, John D.; Yu, Yonghao


    With recent advances in understanding the genomic underpinnings and oncogenic drivers of pathogenesis in different subtypes, it is increasingly clear that proper pretreatment diagnostics are essential for the choice of appropriate treatment options for non-small cell lung cancer (NSCLC). Tumor tissue preservation in optimal cutting temperature (OCT) compound is commonly used in the surgical suite. However, proteins recovered from OCT-embedded specimens pose a challenge for LC-MS/MS experiments, due to the large amounts of polymers present in OCT. Here we present a simple workflow for whole proteome analysis of OCT-embedded NSCLC tissue samples, which involves a simple trichloroacetic acid precipitation step. Comparisons of protein recovery between frozen versus OCT-embedded tissue showed excellent consistency with more than 9200 proteins identified. Using an isobaric labeling strategy, we quantified more than 5400 proteins in tumor versus normal OCT-embedded core needle biopsy samples. Gene ontology analysis indicated that a number of proliferative as well as squamous cell carcinoma (SqCC) marker proteins were overexpressed in the tumor, consistent with the patient's pathology based diagnosis of "poorly differentiated SqCC". Among the most downregulated proteins in the tumor sample, we noted a number of proteins with potential immunomodulatory functions. Finally, interrogation of the aberrantly expressed proteins using a candidate approach and cross-referencing with publicly available databases led to the identification of potential druggable targets in DNA replication and DNA damage repair pathways. We conclude that our approach allows LC-MS/MS proteomic analyses on OCT-embedded lung cancer specimens, opening the way to bring powerful proteomics into the clinic. [Figure not available: see fulltext.

  10. Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

    Zhao, Xiaozheng; Huffman, Kenneth E.; Fujimoto, Junya; Canales, Jamie Rodriguez; Girard, Luc; Nie, Guangjun; Heymach, John V.; Wistuba, Igacio I.; Minna, John D.; Yu, Yonghao


    With recent advances in understanding the genomic underpinnings and oncogenic drivers of pathogenesis in different subtypes, it is increasingly clear that proper pretreatment diagnostics are essential for the choice of appropriate treatment options for non-small cell lung cancer (NSCLC). Tumor tissue preservation in optimal cutting temperature (OCT) compound is commonly used in the surgical suite. However, proteins recovered from OCT-embedded specimens pose a challenge for LC-MS/MS experiments, due to the large amounts of polymers present in OCT. Here we present a simple workflow for whole proteome analysis of OCT-embedded NSCLC tissue samples, which involves a simple trichloroacetic acid precipitation step. Comparisons of protein recovery between frozen versus OCT-embedded tissue showed excellent consistency with more than 9200 proteins identified. Using an isobaric labeling strategy, we quantified more than 5400 proteins in tumor versus normal OCT-embedded core needle biopsy samples. Gene ontology analysis indicated that a number of proliferative as well as squamous cell carcinoma (SqCC) marker proteins were overexpressed in the tumor, consistent with the patient's pathology based diagnosis of "poorly differentiated SqCC". Among the most downregulated proteins in the tumor sample, we noted a number of proteins with potential immunomodulatory functions. Finally, interrogation of the aberrantly expressed proteins using a candidate approach and cross-referencing with publicly available databases led to the identification of potential druggable targets in DNA replication and DNA damage repair pathways. We conclude that our approach allows LC-MS/MS proteomic analyses on OCT-embedded lung cancer specimens, opening the way to bring powerful proteomics into the clinic. [Figure not available: see fulltext.

  11. Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

    Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)


    The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage.

  12. Primary pathogenicity analysis of a Chinese Entamoeba histolytica isolate.

    Luo, Muxia; Feng, Meng; Min, Xiangyang; Li, Xueping; Cai, Junlong; Tachibana, Hiroshi; Cheng, Xunjia


    This study is the first to isolate an Entamoeba histolytica strain from Chinese amoebic patients and to conduct a detailed examination of its virulence. A fecal sample that contains cysts of E. histolytica was obtained from Guangxi province. The sample was cultured axenically and then cloned by limiting dilution, and named as XLAC. In vitro and in vivo tests were conducted to evaluate the virulence of the Entamoeba isolate. The E. histolytica strain XLAC was successfully cloned and cultured axenically. DNA regions that contain hexokinase, glucose-6-phosphate isomerase, phosphoglucomutase, and heavy subunit of lectin genes were amplified by PCR. The PCR products were then sequenced. Virulence analysis suggested that the XLAC strain was similar to the HM1:IMSS strain at the genetic level. In vitro and in vivo tests also implicated these strains to be similar. These findings may be attributed to the low expression levels of pathogenic genes obtained through realtime PCR. The XLAC strain restored its virulence after it was injected into hamster liver. This study may be a good model for studying virulence changes in E. histolytica.

  13. A latency analysis for M2M and OG-like traffic patterns in different HSPA core network configurations

    M. V. Popović


    Full Text Available In this paper we present an analysis intended to reveal possible impacts of core network features on latency for modelled M2M and Online Gaming traffic. Simulations were performed in a live 3G/HSPA network. Test traffic simulating multiplayer real-time games and M2M applications was generated on 10 mobile phones in parallel, sending data to a remote server. APNs with different combinations of hardware and features (proxy server, different GGSNs and firewalls, usage of Service Awareness feature were chosen. The traffic was recorded on the Gn interface in the mobile core. The goal of experiments was to evaluate any eventually significant variation of average recorded RTTs in the core part of mobile network that would clearly indicate either the impact of used APN on delay for a specific traffic pattern, or selectivity of the APN towards different traffic patterns.

  14. Performance Analysis of an EDFA Utilizing a Partially Doped Core Fiber (PDCF)

    Ahad, M. A.; Paul, M. C.; Muhd-Yassin, S. Z.; Mansoor, A.; Abdul-Rashid, H. A.


    The effect of transversal design in Erbium-doped fiber amplifiers' gain and noise figure performance is illustrated in this work. In this work, we investigate experimentally a single pass 980 nm pumped EDFA with partially doped Erbium core fiber (PDCF), which has the core partially doped with Erbium ions. Later, the enumerated results for PDCF are compared with a standard fully doped EDF, having similar Erbium ion doping concentration. The PDCF Amplifier gain and noise figure performance is studied against different pump power and signal power at different operating wavelengths. The noise figure indicates improvement due to reduced spontaneous emission from un-doped region of the core.

  15. Standardization and optimization of core sampling procedure for carbon isotope analysis in eucalyptus and variation in carbon isotope ratios across species and growth conditions

    Raju, M


    Full Text Available and optimization of core sampling procedure for carbon isotope analysis in eucalyptus and variation in carbon isotope ratios across species and growth conditions Mohan Raju, B#; Nuveshen Naidoo*; Sheshshaayee, M. S; Verryn, S. D*; Kamalkannan, R^; Bindumadhava... isotope analysis in Eucalyptus. Methods Expt 1: * Cores were taken from periphery to pith in 5 year old trees of Eucalyptus * Five half sib families of Eucalyptus grandis & E. urophylla were used ? Cores were further subdivided into 5 fragments...

  16. Analysis of ultra-deep pyrosequencing and cloning based sequencing of the basic core promoter/precore/core region of hepatitis B virus using newly developed bioinformatics tools.

    Mukhlid Yousif

    Full Text Available AIMS: The aims of this study were to develop bioinformatics tools to explore ultra-deep pyrosequencing (UDPS data, to test these tools, and to use them to determine the optimum error threshold, and to compare results from UDPS and cloning based sequencing (CBS. METHODS: Four serum samples, infected with either genotype D or E, from HBeAg-positive and HBeAg-negative patients were randomly selected. UDPS and CBS were used to sequence the basic core promoter/precore region of HBV. Two online bioinformatics tools, the "Deep Threshold Tool" and the "Rosetta Tool" (, were built to test and analyze the generated data. RESULTS: A total of 10952 reads were generated by UDPS on the 454 GS Junior platform. In the four samples, substitutions, detected at 0.5% threshold or above, were identified at 39 unique positions, 25 of which were non-synonymous mutations. Sample #2 (HBeAg-negative, genotype D had substitutions in 26 positions, followed by sample #1 (HBeAg-negative, genotype E in 12 positions, sample #3 (HBeAg-positive, genotype D in 7 positions and sample #4 (HBeAg-positive, genotype E in only four positions. The ratio of nucleotide substitutions between isolates from HBeAg-negative and HBeAg-positive patients was 3.5 ∶ 1. Compared to genotype E isolates, genotype D isolates showed greater variation in the X, basic core promoter/precore and core regions. Only 18 of the 39 positions identified by UDPS were detected by CBS, which detected 14 of the 25 non-synonymous mutations detected by UDPS. CONCLUSION: UDPS data should be approached with caution. Appropriate curation of read data is required prior to analysis, in order to clean the data and eliminate artefacts. CBS detected fewer than 50% of the substitutions detected by UDPS. Furthermore it is important that the appropriate consensus (reference sequence is used in order to identify variants correctly.

  17. A Historical Analysis of Primary Mathematics Curricula in Terms of Teaching Principles

    Ozmantar, Mehmet Fatih


    This study carries out a comparative analysis of primary mathematics curricula put into practice during Turkish Republican period. The data for this study are composed of official curricula documents which are examined in terms of teaching principles. The study adopts a qualitative approach and employs document analysis method. The official…

  18. Sustained Attention in Children with Primary Language Impairment: A Meta-Analysis

    Ebert, Kerry Danahy; Kohnert, Kathryn


    Purpose: This study provides a meta-analysis of the difference between children with primary or specific language impairment (LI) and their typically developing peers on tasks of sustained attention. The meta-analysis seeks to determine whether children with LI demonstrate subclinical deficits in sustained attention and, if so, under what…

  19. Percutaneous computed tomography-guided core needle biopsy of soft tissue tumors: results and correlation with surgical specimen analysis

    Chojniak, Rubens; Grigio, Henrique Ramos; Bitencourt, Almir Galvao Vieira; Pinto, Paula Nicole Vieira; Tyng, Chiang J.; Cunha, Isabela Werneck da; Aguiar Junior, Samuel; Lopes, Ademar, E-mail: [Hospital A.C. Camargo, Sao Paulo, SP (Brazil)


    Objective: To evaluate the efficacy of percutaneous computed tomography (CT)-guided core needle biopsy of soft tissue tumors in obtaining appropriate samples for histological analysis, and compare its diagnosis with the results of the surgical pathology as available. Materials and Methods: The authors reviewed medical records, imaging and histological reports of 262 patients with soft-tissue tumors submitted to CT-guided core needle biopsy in an oncologic reference center between 2003 and 2009. Results: Appropriate samples were obtained in 215 (82.1%) out of the 262 patients. The most prevalent tumors were sarcomas (38.6%), metastatic carcinomas (28.8%), benign mesenchymal tumors (20.5%) and lymphomas (9.3%). Histological grading was feasible in 92.8% of sarcoma patients, with the majority of them (77.9%) being classified as high grade tumors. Out of the total sample, 116 patients (44.3%) underwent surgical excision and diagnosis confirmation. Core biopsy demonstrated 94.6% accuracy in the identification of sarcomas, with 96.4% sensitivity and 89.5% specificity. A significant intermethod agreement about histological grading was observed between core biopsy and surgical resection (p < 0.001; kappa = 0.75). Conclusion: CT-guided core needle biopsy demonstrated a high diagnostic accuracy in the evaluation of soft tissue tumors as well as in the histological grading of sarcomas, allowing an appropriate therapeutic planning (author)

  20. In-situ Ice Core Analysis of Longyearbreen Glacier Using a Cryobot: Preparation for the Northern Polar Cap of Mars

    Anderson, F.; Hecht, M. H.; Carsey, F. D.; Conrad, P. G.; Zimmerman, W. F.; French, L. C.; Engelhardt, H.


    A prototype cryobot will be used to provide an in-situ analysis of Longyearbreen glacier, in Svalbard. The cryobot is a small steerable robotic vehicle capable of melting through ice at a rate of ~20 m/day and carries a suite of instruments commonly used for ice core analysis. Terrestrial ice cores record climatological and geological history, such as changing atmospheric chemistry or volcanic eruptions. Unfortunately, coring or drilling in remote and harsh environmental conditions can be difficult and expensive. Furthermore, drilling and coring technologies are limited in penetration depth and commonly contaminate the sample with drilling fluids or surface debris. We present results from a cryobot designed to obtain geologic, climatologic, and biologic data while avoiding the problems of current methods; it can be installed in the ice with minimal effort, can be operated remotely, is relatively inexpensive, and is environmentally safe. The prototype will be used to record optical, pH, conductivity, redox, density, and temperature profiles of the Longyearbreen, glacier in Svalbard, Norway, which is 160 m deep, and located at 75N. These results will be compared with adjacent ice core measurements, for a direct comparison of the two technologies for obtaining science data. The ice core data will also be used to test the sensitivity and operating constraints a suite of instruments under development for use in the cryobot, including visible/near IR spectroscopy, UV fluorescence, and biomass identification. We have proposed the cryobot for use on a Scout class mission to Mars. The Svalbard melt test will serve as a simple Mars analog and a demonstration of the scientific return of the cryobot vehicle and instrument suite.

  1. Effect of aromatherapy massage on pain in primary dysmenorrhea: A meta-analysis.

    Sut, Necdet; Kahyaoglu-Sut, Hatice


    This meta-analysis investigates the effect of aromatherapy massage on pain in primary dysmenorrhea. Randomized controlled trials were searched by keywords in several databases (Pubmed, ISI Web of Sciences, and Google Scholar). Six randomized controlled trials that included 362 participants with primary dysmenorrhea, comparing abdominal aromatherapy massage (n = 184) with massage with placebo oils (n = 178), were analyzed in the meta-analysis. The change in the visual analogue scale (VAS) pain score from the first menstruation cycle to the second cycle at the first menstruation day was used as the primary outcome. Aromatherapy massage with essential oils was superior to massage with placebo oils (standardized mean difference = -1.06 [95% CI: -1.55 to -0.55]). Abdominal aromatherapy massage with essential oils is an effective complementary method to relieve pain in primary dysmenorrhea. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Analysis of the characteristics of microorganisms packed in the ice core of Malan Glacier, Tibet, China

    张晓君; 姚檀栋; 马晓军; 王宁练


    Glacier is a special medium which can conserve a long time chronological information of microorganism. As a preliminary research, from Ice Core3 of Malan glacier (91°45.3’ E, 35°48.4’ N; drilled at 5620 m a.s.l. ), we successfully isolated live microorganisms. 75 strains of bacteria in 10 genera and 6 strains of actinomycetes in 2 genera were isolated from 23 samples. 32 strains bacteria were identified to be Bacillus and 25 strains were B.circulans, B.firmus, B.subtilis and 6. alvei. The genera of bacteria in Malan ice core were similar to that in Greenland and Antarctic ice core. We cannot isolate fungi and alga from Malan ice core, although they are widely distributed in Greenland and Antarctica.

  3. Improvement of Axial Reflector Cross Section Generation Model for PWR Core Analysis

    Shim, Cheon Bo; Lee, Kyung Hoon; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    This paper covers the study for improvement of axial reflector XS generation model. In the next section, the improved 1D core model is represented in detail. Reflector XS generated by the improved model is compared to that of the conventional model in the third section. Nuclear design parameters generated by these two XS sets are also covered in that section. Significant of this study is discussed in the last section. Two-step procedure has been regarded as the most practical approach for reactor core designs because it offers core design parameters quite rapidly within acceptable range. Thus this approach is adopted for SMART (System-integrated Modular Advanced Reac- Tor) core design in KAERI with the DeCART2D1.1/ MASTER4.0 (hereafter noted as DeCART2D/ MASTER) code system. Within the framework of the two-step procedure based SMART core design, various researches have been studied to improve the core design reliability and efficiency. One of them is improvement of reflector cross section (XS) generation models. While the conventional FA/reflector two-node model used for most core designs to generate reflector XS cannot consider the actual configuration of fuel rods that intersect at right angles to axial reflectors, the revised model reflects the axial fuel configuration by introducing the radially simplified core model. The significance of the model revision is evaluated by observing HGC generated by DeCART2D, reflector XS, and core design parameters generated by adopting the two models. And it is verified that about 30 ppm CBC error can be reduced and maximum Fq error decreases from about 6 % to 2.5 % by applying the revised model. Error of AO and axial power shapes are also reduced significantly. Therefore it can be concluded that the simplified 1D core model improves the accuracy of the axial reflector XS and leads to the two-step procedure reliability enhancement. Since it is hard for core designs to be free from the two-step approach, it is necessary to find

  4. Numerical Analysis of Magnetic Force of Dry-Type Air-Core Reactor

    LIUZhi-gang; GENGYing-san; WANGJian-hua


    This paper presents a coupled magnetic-circuit method for computing the magnetic force of air-core reactor under short-time current. The current and the magnetic flux density are computed first and then the magnetic force is obtained. Thus, the dynamic stability performance of air-core reactor can be analyzed at the design stage to reduce experimental cost and shorten the lead-time of product development.

  5. BNL program in support of LWR degraded-core accident analysis

    Ginsberg, T.; Greene, G.A.


    Two major sources of loading on dry watr reactor containments are steam generatin from core debris water thermal interactions and molten core-concrete interactions. Experiments are in progress at BNL in support of analytical model development related to aspects of the above containment loading mechanisms. The work supports development and evaluation of the CORCON (Muir, 1981) and MARCH (Wooton, 1980) computer codes. Progress in the two programs is described in this paper. 8 figures.

  6. The study of 700mm-diameter primary mirror based on topology optimization and sensitivity analysis

    Wang, Xin; He, Xiaoying; Jing, Juanjuan; Feng, Lei; Zhou, Jinsong; Wang, Wei; Li, Yacan; Wei, Lidong


    The primary mirror is an important optical component of space camera. Its performance related to the optical image quality, and the weight directly affects the whole camera weight. The traditional design of primary mirror relies on much experience, lacking of precise theory, and many design parameters obtained by empirical formulas, thus the performance of the result is unstable. For this study, a primary mirror made of SiC with the diameter of 700mm was conceptual designed to get the optimized structure. Then sensitivity analysis was carried out to determine the optimum thickness of the back muscles. Finally, the optimum primary mirror fully satisfied the required was completed, with outstanding mechanical performance and light weight. A comparison between the optimum primary and traditional primary was performed and the results showed that the optimum primary has higher lightweight ratio increased by 5%, higher modal frequency increased by 81Hz.The maximum deformation under gravity reduced by 48nm, PV of the mirror surface reduced by 8.1nm and RMS reduced by 3.1nm. All the results indicated that the optimization method in the paper is reasonable and effective, which gives a reference to the primary mirror design in the future.

  7. High Temperature Reactor (HTR) Deep Burn Core and Fuel Analysis: Design Selection for the Prismatic Block Reactor

    Francesco Venneri; Chang-Keun Jo; Jae-Man Noh; Yonghee Kim; Claudio Filippone; Jonghwa Chang; Chris Hamilton; Young-Min Kim; Ji-Su Jun; Moon-Sung Cho; Hong-Sik Lim; MIchael A. Pope; Abderrafi M. Ougouag; Vincent Descotes; Brian Boer


    The Deep Burn (DB) Project is a U.S. Department of Energy sponsored feasibility study of Transuranic Management using high burnup fuel in the high temperature helium cooled reactor (HTR). The DB Project consists of seven tasks: project management, core and fuel analysis, spent fuel management, fuel cycle integration, TRU fuel modeling, TRU fuel qualification, and HTR fuel recycle. In the Phase II of the Project, we conducted nuclear analysis of TRU destruction/utilization in the HTR prismatic block design (Task 2.1), deep burn fuel/TRISO microanalysis (Task 2.3), and synergy with fast reactors (Task 4.2). The Task 2.1 covers the core physics design, thermo-hydraulic CFD analysis, and the thermofluid and safety analysis (low pressure conduction cooling, LPCC) of the HTR prismatic block design. The Task 2.3 covers the analysis of the structural behavior of TRISO fuel containing TRU at very high burnup level, i.e. exceeding 50% of FIMA. The Task 4.2 includes the self-cleaning HTR based on recycle of HTR-generated TRU in the same HTR. Chapter IV contains the design and analysis results of the 600MWth DB-HTR core physics with the cycle length, the average discharged burnup, heavy metal and plutonium consumptions, radial and axial power distributions, temperature reactivity coefficients. Also, it contains the analysis results of the 450MWth DB-HTR core physics and the analysis of the decay heat of a TRU loaded DB-HTR core. The evaluation of the hot spot fuel temperature of the fuel block in the DB-HTR (Deep-Burn High Temperature Reactor) core under full operating power conditions are described in Chapter V. The investigated designs are the 600MWth and 460MWth DB-HTRs. In Chapter VI, the thermo-fluid and safety of the 600MWth DB-HTRs has been analyzed to investigate a thermal-fluid design performance at the steady state and a passive safety performance during an LPCC event. Chapter VII describes the analysis results of the TRISO fuel microanalysis of the 600MWth and 450

  8. Thermal distribution analysis of multi-core photonic crystal fiber laser

    ZHENG Yi-bo; YAO Jian-quan; ZHANG Lei; WANG Yuan; WEN Wu-qi; JING Lei; DI Zhi-gang; KANG Jian-yi


    The thermal properties of photonic crystal fiber (PCF) laser with 18 circularly distributed cores are investigated by using full-vector finite element method (FEM).The results show that the 18-core PCF has a more effective thermal dispersion construction compared with the single core PCF and 19-core PCF.In addition,the temperature distribution of 18-core PCF laser with different thermal loads is simulated.The results show that the core temperature approaches the fiber drawing value of 1800 K approximately when the thermal load is above 80 W/m which corresponds to the pumping power of 600 W approximately,while the coating temperature approaches the damage value of about 550 K when the thermal load is above 15 W/m which corresponds to the pumping power of 110 W approximately.Therefore the fiber cooling is necessary to achieve power scaling.Compared with other different cooling systems,the copper cooling scheme is found to be an effective method to reduce the thermal effects.

  9. Novel magnetic core materials impact modelling and analysis for minimization of RF heating loss

    Ghosh, Bablu Kumar; Mohamad, Khairul Anuar; Saad, Ismail


    The eddy current that exists in RF transformer/inductor leads to generation of noise/heat in the circuit and ultimately reduces efficiency in RF system. Eddy current is generated in the magnetic core of the inductor/transformer largely determine the power loss for power transferring process. The losses for high-frequency magnetic components are complicated due to both the eddy current variation in magnetic core and copper windings reactance variation with frequency. Core materials permeability and permittivity are also related to variation of such losses those linked to the operating frequency. This paper will discuss mainly the selection of novel magnetic core materials for minimization of eddy power loss by using the approach of empirical equation and impedance plane simulation software TEDDY V1.2. By varying the operating frequency from 100 kHz to 1GHz and magnetic flux density from 0 to 2 Tesla, the eddy power loss is evaluated in our study. The Nano crystalline core material is found to be the best core material due to its low eddy power loss at low conductivity for optimum band of frequency application.

  10. Thermodynamics of greenhouse systems for the northern latitudes: analysis, evaluation and prospects for primary energy saving.

    Bronchart, Filip; De Paepe, Michel; Dewulf, Jo; Schrevens, Eddie; Demeyer, Peter


    In Flanders and the Netherlands greenhouse production systems produce economically important quantities of vegetables, fruit and ornamentals. Indoor environmental control has resulted in high primary energy use. Until now, the research on saving primary energy in greenhouse systems has been mainly based on analysis of energy balances. However, according to the thermodynamic theory, an analysis based on the concept of exergy (free energy) and energy can result in new insights and primary energy savings. Therefore in this paper, we analyse the exergy and energy of various processes, inputs and outputs of a general greenhouse system. Also a total system analysis is then performed by linking the exergy analysis with a dynamic greenhouse climate growth simulation model. The exergy analysis indicates that some processes ("Sources") lie at the origin of several other processes, both destroying the exergy of primary energy inputs. The exergy destruction of these Sources is caused primarily by heat and vapour loss. Their impact can be compensated by exergy input from heating, solar radiation, or both. If the exergy destruction of these Sources is reduced, the necessary compensation can also be reduced. This can be accomplished through insulating the greenhouse and making the building more airtight. Other necessary Sources, namely transpiration and loss of CO2, have a low exergy destruction compared to the other Sources. They are therefore the best candidate for "pump" technologies ("vapour heat pump" and "CO2 pump") designed to have a low primary energy use. The combination of these proposed technologies results in an exergy efficient greenhouse with the highest primary energy savings. It can be concluded that exergy analyses add additional information compared to only energy analyses and it supports the development of primary energy efficient greenhouse systems.

  11. Developing Fully Coupled Dynamical Reactor Core Isolation System Models in RELAP-7 for Extended Station Black-Out Analysis

    Haihua Zhao; Ling Zou; Hongbin Zhang; David Andrs; Richard Martineau


    The reactor core isolation cooling (RCIC) system in a boiling water reactor (BWR) provides makeup water to the reactor vessel for core cooling when the main steam lines are isolated and the normal supply of water to the reactor vessel is lost. It was one of the very few safety systems still available during the Fukushima Daiichi accidents after the tsunamis hit the plants and the system successfully delayed the core meltdown for a few days for unit 2 & 3. Therefore, detailed models for RCIC system components are indispensable to understand extended station black-out accidents (SBO) for BWRs. As part of the effort to develop the new generation reactor system safety analysis code RELAP-7, major components to simulate the RCIC system have been developed. This paper describes the models for those components such as turbine, pump, and wet well. Selected individual component test simulations and a simplified SBO simulation up to but before core damage is presented. The successful implementation of the simplified RCIC and wet well models paves the way to further improve the models for safety analysis by including more detailed physical processes in the near future.

  12. Joint analysis of celestial pole offset and free core nutation series

    Malkin, Zinovy


    Three combined celestial pole offset (CPO) series computed at the Paris Observatory (C04), the United States Naval Observatory (USNO), and the International VLBI Service for Geodesy and Astrometry (IVS), as well as six free core nutation (FCN) models, were compared from different perspectives, such as stochastic and systematic differences, and FCN amplitude and phase variations. The differences between the C04 and IVS CPO series were mostly stochastic, whereas a low-frequency bias at the level of several tens of μas was found between the C04 and USNO CPO series. The stochastic differences between the C04 and USNO series became considerably smaller when computed at the IVS epochs, which can indicate possible problems with the interpolation of the IVS data at the midnight epochs during the computation of the C04 and USNO series. The comparison of the FCN series showed that the series computed with similar window widths of 1.1-1.2 years were close to one another at a level of 10-20 μas, whereas the differences between these series and the series computed with a larger window width of 4 and 7 years reached 100 μas. The dependence of the FCN model on the underlying CPO series was investigated. The RMS differences between the FCN models derived from the C04, USNO, and IVS CPO series were at a level of approximately 15 μas, which was considerably smaller than the differences among the CPO series. The analysis of the differences between the IVS, C04, and USNO CPO series suggested that the IVS series would be preferable for both precession-nutation and FCN-related studies.

  13. Joint analysis of celestial pole offset and free core nutation series

    Malkin, Zinovy


    Three combined celestial pole offset (CPO) series computed at the Paris Observatory (C04), the United States Naval Observatory (USNO), and the International VLBI Service for Geodesy and Astrometry (IVS), as well as six free core nutation (FCN) models, were compared from different perspectives, such as stochastic and systematic differences, and FCN amplitude and phase variations. The differences between the C04 and IVS CPO series were mostly stochastic, whereas a low-frequency bias at the level of several tens of μ as was found between the C04 and USNO CPO series. The stochastic differences between the C04 and USNO series became considerably smaller when computed at the IVS epochs, which can indicate possible problems with the interpolation of the IVS data at the midnight epochs during the computation of the C04 and USNO series. The comparison of the FCN series showed that the series computed with similar window widths of 1.1-1.2 years were close to one another at a level of 10-20 μ as, whereas the differences between these series and the series computed with a larger window width of 4 and 7 years reached 100 μ as. The dependence of the FCN model on the underlying CPO series was investigated. The RMS differences between the FCN models derived from the C04, USNO, and IVS CPO series were at a level of approximately 15 μ as, which was considerably smaller than the differences among the CPO series. The analysis of the differences between the IVS, C04, and USNO CPO series suggested that the IVS series would be preferable for both precession-nutation and FCN-related studies.

  14. GENIE: a software package for gene-gene interaction analysis in genetic association studies using multiple GPU or CPU cores.

    Chikkagoudar, Satish; Wang, Kai; Li, Mingyao


    Gene-gene interaction in genetic association studies is computationally intensive when a large number of SNPs are involved. Most of the latest Central Processing Units (CPUs) have multiple cores, whereas Graphics Processing Units (GPUs) also have hundreds of cores and have been recently used to implement faster scientific software. However, currently there are no genetic analysis software packages that allow users to fully utilize the computing power of these multi-core devices for genetic interaction analysis for binary traits. Here we present a novel software package GENIE, which utilizes the power of multiple GPU or CPU processor cores to parallelize the interaction analysis. GENIE reads an entire genetic association study dataset into memory and partitions the dataset into fragments with non-overlapping sets of SNPs. For each fragment, GENIE analyzes: 1) the interaction of SNPs within it in parallel, and 2) the interaction between the SNPs of the current fragment and other fragments in parallel. We tested GENIE on a large-scale candidate gene study on high-density lipoprotein cholesterol. Using an NVIDIA Tesla C1060 graphics card, the GPU mode of GENIE achieves a speedup of 27 times over its single-core CPU mode run. GENIE is open-source, economical, user-friendly, and scalable. Since the computing power and memory capacity of graphics cards are increasing rapidly while their cost is going down, we anticipate that GENIE will achieve greater speedups with faster GPU cards. Documentation, source code, and precompiled binaries can be downloaded from

  15. New approach to primary mass composition analysis with simultaneous use of ground and fluorescence detectors data

    Yushkov, A; Aramo, C; Guarino, F; D'Urso, D; Valore, L


    We study the possibility to reconstruct primary mass composition with the use of combinations of basic shower characteristics, measured in hybrid experiments, such as depth of shower maximum from fluorescence side and signal in water Cherenkov tanks or in plastic scintillators from the ground side. To optimize discrimination performance of shower observables combinations we apply Fisher's discriminant analysis and give statistical estimates of separation of the obtained distributions on Fisher variables for proton and iron primaries. At the final stage we apply Multiparametric Topological Analysis to these distributions to extract composition from prepared mixtures with known fractions of showers from different primary particles. It is shown, that due to high sensitivity of water tanks to muons, combination of signal in them with $\\xmax$ looks especially promising for mass composition analysis, provided the energy is determined from longitudinal shower profile.

  16. Using borehole core analysis to reveal Late Quaternary paleoearthquakes along the Nankou-Sunhe Fault,Beijing


    The Nankou-Sunhe Fault is a buried active normal fault that traverses the urban area of Beijing.Its seismic risks have caused considerable concerns.This paper studies paleoearthquakes along this fault by analyzing and correlating bore-hole cores obtained from triple-tube coring,incorporating experience acquired from trenching.As a result,a model for identifying earthquake-derived colluvium by sediment-core analysis is proposed.Triple-tube coring technique is useful to collect continuous undis-turbed soil core near the Nankou-Sunhe Fault.By identifying fault-scarp colluviums,determining cumulative displacement,and analysing stratum thickening on the hanging wall,we are able to establish a preliminary paleoearthquake sequence consisting of 13 surface-rupturing events since 60 ka.The seismic history can be divided into three periods based on different recurrence intervals.Between 60 and 40 ka,three earthquakes occurred with recurrence interval of ~10 ka.From 40 to 25 ka,there were six earthquakes with the recurrence interval of about 2.5 ka.In the last 25 ka,four earthquakes have taken place with the recurrence interval varying considerably.The recurrence interval between the last three events is ~5 ka.Smaller recurrence intervals correspond to stages of faster fault slip.The coseismic displacement of a single event is 0.8 to 2.2 m,average 1.4 m,largely equivalent to moment magnitudes 6.7-7.1.This study demonstrates the feasibility of bore-hole drilling in investigating paleoearthquakes along normal faults.It also suggests that closely spaced boreholes with continuous undisturbed cores are essential for reconstructing the complete paleoearthquake sequence.

  17. A new method for high-resolution methane measurements on polar ice cores using continuous flow analysis.

    Schüpbach, Simon; Federer, Urs; Kaufmann, Patrik R; Hutterli, Manuel A; Buiron, Daphné; Blunier, Thomas; Fischer, Hubertus; Stocker, Thomas F


    Methane (CH4) is the second most important anthropogenic greenhouse gas in the atmosphere. Rapid variations of the CH4 concentration, as frequently registered, for example, during the last ice age, have been used as reliable time markers for the definition of a common time scale of polar ice cores. In addition, these variations indicate changes in the sources of methane primarily associated with the presence of wetlands. In order to determine the exact time evolution of such fast concentration changes, CH4 measurements of the highest resolution in the ice core archive are required. Here, we present a new, semicontinuous and field-deployable CH4 detection method, which was incorporated in a continuous flow analysis (CFA) system. In CFA, samples cut along the axis of an ice core are melted at a melt speed of typically 3.5 cm/min. The air from bubbles in the ice core is extracted continuously from the meltwater and forwarded to a gas chromatograph (GC) for high-resolution CH4 measurements. The GC performs a measurement every 3.5 min, hence, a depth resolution of 15 cm is achieved atthe chosen melt rate. An even higher resolution is not necessary due to the low pass filtering of air in ice cores caused by the slow bubble enclosure process and the diffusion of air in firn. Reproducibility of the new method is 3%, thus, for a typical CH4 concentration of 500 ppb during an ice age, this corresponds to an absolute precision of 15 ppb, comparable to traditional analyses on discrete samples. Results of CFA-CH4 measurements on the ice core from Talos Dome (Antarctica) illustrate the much higher temporal resolution of our method compared with established melt-refreeze CH4 measurements and demonstrate the feasibility of the new method.

  18. Goober: a fully integrated and user-friendly microarray data management and analysis solution for core labs and bench biologists.

    Luo, Wen; Gudipati, Murali; Jung, Kevin; Chen, Mao; Marschke, Keith B


    Despite the large number of software tools developed to address different areas of microarray data analysis, very few offer an all-in-one solution with little learning curve. For microarray core labs, there are even fewer software packages available to help with their routine but critical tasks, such as data quality control (QC) and inventory management. We have developed a simple-to-use web portal to allow bench biologists to analyze and query complicated microarray data and related biological pathways without prior training. Both experiment-based and gene-based analysis can be easily performed, even for the first-time user, through the intuitive multi-layer design and interactive graphic links. While being friendly to inexperienced users, most parameters in Goober can be easily adjusted via drop-down menus to allow advanced users to tailor their needs and perform more complicated analysis. Moreover, we have integrated graphic pathway analysis into the website to help users examine microarray data within the relevant biological content. Goober also contains features that cover most of the common tasks in microarray core labs, such as real time array QC, data loading, array usage and inventory tracking. Overall, Goober is a complete microarray solution to help biologists instantly discover valuable information from a microarray experiment and enhance the quality and productivity of microarray core labs. The whole package is freely available at A demo web server is available at

  19. Estimative of core damage frequency in IPEN IEA-R1 research reactor due to the initiating events of loss of flow caused by channel blockage and loss of coolant caused by a large rupture in the pipe of the primary circuit - PSA level 1

    Hirata, Daniel Massami [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Sao Paulo, SP (Brazil); Sabundjian, Gaiane, E-mail: gdjian@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) Sao Paulo, SP (Brazil)


    This work applies the methodology of Probabilistic Safety Assessment Level 1 to the research reactor IEA-R1 IPEN-CNEN/SP. Two categories of identified initiating events of accidents in the reactor are studied: loss of flow and loss of primary coolant. Among the initiating events, blockage of flow channel and loss of cooling fluid caused by large pipe rupture in the primary circuit are chosen for a detailed analysis. The event tree technique is used to analyze the evolution of the accident, including the actuation or the fail of actuation of the safety systems and the reactor damages. Using the fault tree the reliability of the following reactor safety systems is evaluated: reactor shutdown system, isolation of the reactor pool, Emergency Core Cooling System (ECCS) and the electric system. Estimative for the frequency of damage to the reactor core and the probability of failure of the analyzed systems are calculated. The estimated values for the frequencies of core damage are within the expected margins and are of the same order of magnitude as those found for similar reactors. The reliability of the reactor shutdown system, isolation of the reactor pool and ECCS are satisfactory for the conditions in which these systems are required. However, for the electric system it is suggested an upgrade to increase its reliability. (author)

  20. Digital core based transmitted ultrasonic wave simulation and velocity accuracy analysis

    Zhu, Wei; Shan, Rui


    Transmitted ultrasonic wave simulation (TUWS) in a digital core is one of the important elements of digital rock physics and is used to study wave propagation in porous cores and calculate equivalent velocity. When simulating wave propagates in a 3D digital core, two additional layers are attached to its two surfaces vertical to the wave-direction and one planar wave source and two receiver-arrays are properly installed. After source excitation, the two receivers then record incident and transmitted waves of the digital rock. Wave propagating velocity, which is the velocity of the digital core, is computed by the picked peak-time difference between the two recorded waves. To evaluate the accuracy of TUWS, a digital core is fully saturated with gas, oil, and water to calculate the corresponding velocities. The velocities increase with decreasing wave frequencies in the simulation frequency band, and this is considered to be the result of scattering. When the pore fluids are varied from gas to oil and finally to water, the velocity-variation characteristics between the different frequencies are similar, thereby approximately following the variation law of velocities obtained from linear elastic statics simulation (LESS), although their absolute values are different. However, LESS has been widely used. The results of this paper show that the transmission ultrasonic simulation has high relative precision.

  1. Design and finite element analysis of lightmass silicon carbide primary mirror

    HAN Yuan-yuan; ZHANG Yu-min; HAN Jie-cai; ZHANG Jian-han; YAO Wang; ZHOU Yu-feng


    Primary mirror is one of the key components in the space remote sensing system. To minimize the mass of the mirror without compromising its stiffness and decrease the deformation of the mirror surface at the different temperatures are the mainly two objects in the development of the primary mirror. Silicon carbide (SiC),the most promising optical material,was used as the material of the primary mirror with triangle lightmass structure in a Cassegrain system. By using finite element method,the properties of the SiC mirror were compared with that of the traditional Be mirror and fused silica mirror. The results of static,dynamic and thermo-mechanical analysis indicate that the deformation of the mirror surface caused by temperature field is much bigger than that caused by gravity field. The SiC mirror has the best overall properties,and the SiC material is much suitable for the primary mirror.

  2. Core competence and dominant logic: contributions to the analysis of merger and acquisition process

    Marcelo Pereira Binder


    Full Text Available Mergers and acquisitions are one of the most important strategic decisions a company can take. In the 1980s and 1990s, mergers and acquisitions have occurred in large numbers of companies and several theories have been developed to explain the phenomenon. However, most of these theories are related to the financial area. But, non-quantifiable aspects, such as core competencies and dominant logic, have been relegated to the background. Identified this gap, this paper proposes the inclusion of the concept of core competence and dominant logic as an analytical tool to validate a merger process. To do so, this article has rescued the discussion of these concepts in the business strategy field and a case that did not achieve the proposed goals with the merger was examined from this perspective. The result evidence that the adoption of the concepts of core competence and dominant logic helps explain a new insights with the merger process.

  3. Nonlinear Thermo-mechanical Finite Element Analysis of Polymer Foam Cored Sandwich Structures including Geometrical and Material Nonlinearity

    Palleti, Hara Naga Krishna Teja; Thomsen, Ole Thybo; Taher, Siavash Talebi;

    In this paper, polymer foam cored sandwich structures with fibre reinforced composite face sheets subjected to combined mechanical and thermal loads will be analysed using the commercial FE code ABAQUS® incorporating both material and geometrical nonlinearity. Large displacements and rotations ar...... are included in the analysis. The full nonlinear stress-strain curves up to failure will be considered for the polymer foams at different temperatures to study the effect of material nonlinearity in detail....

  4. Numerical Analysis of Heat Storage and Heat Conductivity in the Concrete Hollow Core Deck Element

    Pomianowski, Michal Zbigniew; Heiselberg, Per; Jensen, Rasmus Lund;


    the overall heat transfer and heat storage in the hollow-core decks. The presented results allow comparison between detailed results from 2D-COMSOL simulations and simple 1D calculations from the whole building simulation tool such as BSim program and moreover, it is possible to validate the calculation...... method in BSim for the concrete deck element with air voids. Finally, this paper presents a comparison of the calculated heat conductivity of the hollow-core concrete deck and the measured heat conductivity for the same deck by using hot box apparatus....

  5. Reactivity insertion transient analysis for KUR low-enriched uranium silicide fuel core

    Shen, Xiuzhong; Nakajima, Ken; Unesaki, Hironobu; Mishima, Kaichiro


    The purpose of this study is to realize the full core conversion from the use of High Enriched Uranium (HEU) fuels to the use of Low Enriched Uranium (LEU) fuels in Kyoto University Research Reactor (KUR). Although the conversion of nuclear energy sources is required to keep the safety margins and reactor reliability based on KUR HEU core, the uranium density (3.2 gU/cm3) and enrichment (20%) of LEU fuel (U3Si2–AL) are quite different from the uranium density (0.58 gU/cm3) and enrichment (93%...

  6. Numerical simulation and analysis of losses in air-core plastic photonic bandgap fibers

    Tieshan Guan; Mingyang Chen; Zhilong Zhang; Rongjin Yu


    @@ The loss properties of air-core plastic photonic bandgap fibers are analyzed by multipole method. Despite the relatively large absorption loss of plastics (PMMA), the contribution of material absorption loss can be reduced significantly through appropriate selection of operating wavelength, number of cladding air-hole rings, radius of air-core, and position of photonic band gap. The transmission loss in this type of fiber can be decreased by an order of magnitude in comparison with that of conventional plastic optical fiber.

  7. Optimization of High-Resolution Continuous Flow Analysis for Transient Climate Signals in Ice Cores

    Bigler, Matthias; Svensson, Anders; Kettner, Ernesto


    meltwater conductivity detection modules. The system is optimized for high- resolution determination of transient signals in thin layers of deep polar ice cores. Based on standard measurements and by comparing sections of early Holocene and glacial ice from Greenland, we find that the new system features...... a depth resolution in the ice of a few millimeters which is considerably better than other CFA systems. Thus, the new system can resolve ice strata down to 10 mm thickness and has the potential of identifying annual layers in both Greenland and Antarctic ice cores throughout the last glacial cycle....

  8. Two-mode elliptical-core weighted fiber sensors for vibration analysis

    Vengsarkar, Ashish M.; Murphy, Kent A.; Fogg, Brian R.; Miller, William V.; Greene, Jonathan A.; Claus, Richard O.


    Two-mode, elliptical-core optical fibers are demonstrated in weighted, distributed and selective vibration-mode-filtering applications. We show how appropriate placement of optical fibers on a vibrating structure can lead to vibration mode filtering. Selective vibration-mode suppression on the order of 10 dB has been obtained using tapered two-mode, circular-core fibers with tapering functions that match the second derivatives of the modes of vibration to be enhanced. We also demonstrate the use of chirped, two-mode gratings in fibers as spatial modal sensors that are equivalents of shaped piezoelectric sensors.

  9. Proteomics Core

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  10. Proteomics Core

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in...

  11. A Spitzer Survey of Young Stellar Clusters within One Kiloparsec of the Sun: Cluster Core Extraction and Basic Structural Analysis

    Gutermuth, R A; Myers, P C; Allen, L E; Pipher, J L; Fazio, G G


    We present a uniform mid-infrared imaging and photometric survey of 36 young, nearby, star-forming clusters and groups using {\\it Spitzer} IRAC and MIPS. We have confidently identified and classified 2548 young stellar objects using recently established mid-infrared color-based methods. We have devised and applied a new algorithm for the isolation of local surface density enhancements from point source distributions, enabling us to extract the overdense cores of the observed star forming regions for further analysis. We have compiled several basic structural measurements of these cluster cores from the data, such as mean surface densities of sources, cluster core radii, and aspect ratios, in order to characterize the ranges for these quantities. We find that a typical cluster core is 0.39 pc in radius, has 26 members with infrared excess in a ratio of Class II to Class I sources of 3.7, is embedded in a $A_K$=0.8 mag cloud clump, and has a surface density of 60 pc$^{-2}$. We examine the nearest neighbor dista...

  12. A Computer-Aided Bibliometrics System for Journal Citation Analysis and Departmental Core Journal Ranking List Generation

    Yih-Chearng Shiue


    Full Text Available Due to the tremendous increase and variation in serial publications, faculties in department of university are finding it difficult to generate and update their departmental core journal list regularly and accurately, and libraries are finding it difficult to maintain their current serial collection for different departments. Therefore, the evaluation of a departmental core journal list is an important task for departmental faculties and librarians. A departmental core journal list not only helps departments understand research performances of faculties and students, but also helps librarians make decisions about which journals to retain and which to cancel. In this study, a Computer-Aided Bibliometrics System was implemented and two methodologies (JCDF and LibJF were proposed in order to generate a departmental core journal ranking list and make the journal citation analysis. Six departments were taken as examples, with MIS as the major one. One journal citation pattern was found and the ratio of Turning point-to-No. journal was always around 0.07 among the 10 journals and 6 departments. After comparing with four methodologies via overlapping rate and standard deviation distances, the two proposed methodologies were shown to be better than questionnaire and library subscription method.

  13. Passive prediction of core self-evaluation on job-burnout for midwives from primary hospitals%基层医院助产士核心自我评价对工作倦怠的负向预测

    蔡迪利; 赵秀敏; 陈志琴


    Objective To study the prediction of core self-evaluation on job-burnout for midwives from primary hospitals. Method Investigate 45 clinical midwives by Core Self-evaluation Scale and Job-Burnout Inventory. Result The total score of core self-evaluation is (33. 46 ± 4. 96). The score of personal accomplishment reduction is lower than Hangzhou Norm and scores of emotional exhaustion and dcpcrsonalization arc higher than Hangzhou Norm in Job-Burnout Inventory. There is correlation between Burnout core self-evaluation and dcpcrsonalization, emotional exhaustion. Conclusion Level of core self-evaluation has negative correlation with job-burnout for midwives from primary hospitals.%目的 探讨基层医院助产士核心自我评价对工作倦怠的预测.方法采用核心自我评价量表和工作倦怠量表对45名临床一线助产士进行调查.结果 核心自我评价的总分为(33.46±4.96)分;工作倦怠测评中,个人成就感降低得分低于杭州常模,情感耗竭和去人格化得分高于杭州常模;核心自我评价与工作倦怠中的去人格化、情感耗竭有相关性.结论 基层医院助产士的核心自我评价水平与工作倦怠呈负相关.

  14. [Core research areas on addiction in Spain through the Web of Science bibliographic coupling analysis (2000-2013)].

    G, González-Alcaide; A, Calafat; E, Becoña


    The present study identifies the main Spanish core research areas in the area of addictions through the bibliographic coupling analysis of the publications at the Web of Science under the substance abuse heading. The bibliographic coupling methodology is the analytical procedure that determines the thematic-intellectual proximity of the documents under consideration through the identification of the shared or simultaneously cited bibliography by those documents. A factor analysis and network analysis have been carried out to cluster documents, graphically represent the existing core research areas, and analyse the interrelations between them. We have identified 30 core research areas. Alcohol is the topic of attention of 17 areas and cocaine has a strong presence in 6. Heroin and opiates are only present as prominent substances in 4 areas and cannabis and tobacco in other two for each substance. It has been found that there is a significant degree of fragmentation in the area, with the existence of numerous research foci but with few connections with each other and few documents showing shared common knowledge. Also noteworthy is the large number of emerging research areas, reflecting an incipient stage in many of the research topics. Consideration must be placed in promoting scientific consensus and cohesion of the discipline as well as to encouraging the consolidation of main lines that respond to the social problems and research challenges.

  15. Development of the Northern European Ribes core collection based on a microsatellite (SSR) marker diversity analysis

    Antonius, Kristiina; Karhu, S.; Kaldmäe, H.;


    The purpose of the study was to support the selection process of the most valuable currant and gooseberry accessions cultivated in Northern Europe, in order to establish a decentralized core collection and, following the selection, to ensure sufficient genetic diversity in the selected collection...

  16. Three-dimensional vortex analysis and aeroacoustic source characterization of jet core breakdown

    Violato, D.; Scarano, F.


    The three-dimensional behavior of jet core breakdown is investigated with experiments conducted on a free water jet at Re = 5000 by time-resolved tomographic particle image velocimetry (TR-TOMO PIV). The investigated domain encompasses the range between 0 and 10 jet diameters. The characteristic pul

  17. Multiphysics Computational Analysis of a Solid-Core Nuclear Thermal Engine Thrust Chamber

    Wang, Ten-See; Canabal, Francisco; Cheng, Gary; Chen, Yen-Sen


    The objective of this effort is to develop an efficient and accurate computational heat transfer methodology to predict thermal, fluid, and hydrogen environments for a hypothetical solid-core, nuclear thermal engine - the Small Engine. In addition, the effects of power profile and hydrogen conversion on heat transfer efficiency and thrust performance were also investigated. The computational methodology is based on an unstructured-grid, pressure-based, all speeds, chemically reacting, computational fluid dynamics platform, while formulations of conjugate heat transfer were implemented to describe the heat transfer from solid to hydrogen inside the solid-core reactor. The computational domain covers the entire thrust chamber so that the afore-mentioned heat transfer effects impact the thrust performance directly. The result shows that the computed core-exit gas temperature, specific impulse, and core pressure drop agree well with those of design data for the Small Engine. Finite-rate chemistry is very important in predicting the proper energy balance as naturally occurring hydrogen decomposition is endothermic. Locally strong hydrogen conversion associated with centralized power profile gives poor heat transfer efficiency and lower thrust performance. On the other hand, uniform hydrogen conversion associated with a more uniform radial power profile achieves higher heat transfer efficiency, and higher thrust performance.

  18. The Effectiveness of UK Student Counselling Services: An Analysis Using the CORE System

    Connell, Janice; Barkham, Michael; Mellor-Clark, John


    Despite concern surrounding the mental health of students, brought about by the government's policy of widening participation and increasing demands upon students, the effectiveness of student counselling has been a neglected research area. This study examines data from seven UK student counselling services using the CORE System in the routine…

  19. Summary and Analysis of a Survey of Graduate Core Courses in Comparative Politics.

    McHenry, Dean E., Jr.


    The findings of a study of comparative politics core course syllabi offered by a sample of political science departments in the United States are summarized. The purposes of the study were to assess the state of the subdiscipline and to help with an exchange of ideas between teachers. (BSR)

  20. The Common Core State Standards Initiative: An Event History Analysis of State Adoption

    LaVenia, Mark; Cohen-Vogel, Lora; Lang, Laura B.


    Today, with states' near-universal adoption of the Common Core State Standards, the political system has achieved that which was not possible less than 2 decades ago. Just why this is so remains unanswered. Some observers have attributed states' embrace of the standards to the substantial financial incentives that the federal government embedded…

  1. Incorporation of phenomenological uncertainties in probabilistic safety analysis - application to LMFBR core disruptive accident energetics

    Najafi, B; Theofanous, T G; Rumble, E T; Atefi, B


    This report describes a method for quantifying frequency and consequence uncertainty distribution associated with core disruptive accidents (CDAs). The method was developed to estimate the frequency and magnitude of energy impacting the reactor vessel head of the Clinch River Breeder Plant (CRBRP) given the occurrence of hypothetical CDAs. The methodology is illustrated using the CRBR example.

  2. COCO: a computer program for seismic analysis of a single column of the HTGR core

    Rickard, N.D.


    The document serves as a user's manual and theoretical manual for the COCO code. COCO is a nonlinear numerical integration program designed to analyze a single column of the HTGR core for seismic excitation. Output of the code includes dowel forces, collision forces, and a time history of the motion of the blocks.

  3. Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots

    Transcription initiation, essential to gene expression regulation, involves recruitment of basal transcription factors to the core promoter elements (CPEs). The distribution of currently known CPEs across plant genomes is largely unknown. This is the first large scale genome-wide report on the compu...

  4. Analysis of phosphorus forms in sediment cores from ephemeral ponds on Ardley Island, West Antarctica

    YANG Lianjiao; QIN Xianyan; SUN Liguang; HUANG Tao; WANG Yuhong


    The guano of penguins, other seabirds, and pinnipeds is an important source of phosphorus in the ecosystems of Antarctica. To study the vertical distribution of phosphorus in sediments influenced by penguins, we measured phosphorus forms in two sediment cores (G1 and Q2) from ephemeral ponds on Ardley Island. We also investigated the correlations between these phosphorus forms and physicochemical characteristics. Inorganic phosphorus was the main form of phosphorus in both cores. The vertical distribution patterns of phosphorus forms in G1 and Q2 differed, indicating different sedimentary sources. The G1 sediment profile was more influenced by penguin guano than the Q2 profile, and as a result sediments in the G1 core had higher total phosphorus, non-apatite inorganic phosphorus, and apatite phosphorus content. The findings from two ephemeral ponds on Ardley Island indicate that the contribution of penguin guano to organic matter in G1 core has increased in recent times, while Q2 showed a relatively larger contribution from mosses in ancient times, evident from the lithology and the vertical trend in organic matter.

  5. Library and Information Science Research: An Analysis of the 1984 Core Journal Literature.

    Feehan, Pat; And Others

    This report examines the 1984 library and information science literature in order to characterize, analyze, and evaluate the published research of the field. The subjects and methods of research, types of libraries studied, and analytical techniques used are examined; a "core" journal group of 91 sources is established; and the amount…

  6. Common Core Standards, Professional Texts, and Diverse Learners: A Qualitative Content Analysis

    Yanoff, Elizabeth; LaDuke, Aja; Lindner, Mary


    This research study questioned the degree to which six professional texts guiding implementation of the Common Core Standards in reading address the needs of diverse learners. For the purposes of this research, diverse learners were specifically defined as above grade level readers, below grade level readers, and English learners. The researchers…

  7. A diagnostic rule for acute gouty arthritis in primary care without joint fluid analysis.

    Janssens, H.J.E.M.; Fransen, J.; Lisdonk, E.H. van de; Riel, P.L.C.M. van; Weel, C. van; Janssen, M.


    BACKGROUND: Most cases of acute gouty arthritis are diagnosed in primary care and without joint fluid analysis in many instances. Our objectives were to estimate the validity of this diagnosis by family physicians and to develop a diagnostic rule. METHODS: Patients with monoarthritis recruited in an

  8. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

    Melum, Espen; Franke, Andre; Schramm, Christoph; Weismueller, Tobias J.; Gotthardt, Daniel Nils; Offner, Felix A.; Juran, Brian D.; Laerdahl, Jon K.; Labi, Verena; Bjoernsson, Einar; Weersma, Rinse K.; Henckaerts, Liesbet; Teufel, Andreas; Rust, Christian; Ellinghaus, Eva; Balschun, Tobias; Boberg, Kirsten Muri; Ellinghaus, David; Bergquist, Annika; Sauer, Peter; Ryu, Euijung; Hov, Johannes Roksund; Wedemeyer, Jochen; Lindkvist, Bjoern; Wittig, Michael; Porte, Robert J.; Holm, Kristian; Gieger, Christian; Wichmann, H-Erich; Stokkers, Pieter; Ponsioen, Cyriel Y.; Runz, Heiko; Stiehl, Adolf; Wijmenga, Cisca; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Villunger, Andreas; Schrumpf, Erik; Lazaridis, Konstantinos N.; Manns, Michael P.; Schreiber, Stefan; Karlsen, Tom H.

    Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and

  9. Singing and Vocal Instruction in Primary Schools: An Analysis from Six Case Studies in Spain

    Cuadrado, Albina; Rusinek, Gabriel


    This is an analysis of how specialist music teachers sing and teach how to sing, based on data collected from six case studies carried out in Spanish primary schools. The study aimed at understanding classroom singing practices, and in particular the provision or absence of vocal instruction in relation with teachers' singing models. The findings…

  10. Patterns of Discursive Interactions in Primary Classrooms: An Application of Social Network Analysis

    Mameli, Consuelo; Mazzoni, Elvis; Molinari, Luisa


    This study aimed to investigate whether social network analysis (SNA) is a useful method for identifying different discursive patterns in everyday classroom activities. The material analysed came from 20 teacher-led lessons that were video-recorded in small-size classes in Italian public primary schools. SNA was used to measure classroom relations…

  11. Multivoxel fMRI analysis of color tuning in human primary visual cortex

    Parkes, Laura M.; Marsman, Jan-Bernard C.; Oxley, David C.; Goulermas, John Y.; Wuerger, Sophie M.


    We use multivoxel pattern analysis (MVPA) to study the spatial clustering of color-selective neurons in the human brain. Our main objective was to investigate whether MVPA reveals the spatial arrangements of color-selective neurons in human primary visual cortex (V1). We measured the distributed fMR

  12. A Meta-Analysis of Adult-Rated Child Personality and Academic Performance in Primary Education

    Poropat, Arthur E.


    Background: Personality is reliably associated with academic performance, but personality measurement in primary education can be problematic. Young children find it difficult to accurately self-rate personality, and dominant models of adult personality may be inappropriate for children. Aims: This meta-analysis was conducted to determine the…

  13. An Analysis of Music Courses Offered in the Primary School Teacher Education Programs in Turkey

    Özgül, Ilhan


    The aim of this study was to analyze music courses applied within the scope of compulsory courses in the primary school teacher training model in Turkey. Being qualitative in nature, the current study utilized document analysis method. Towards the stated aim, four approaches were discussed. The first one is related to the titles of the music…

  14. Socialization Objectives of Chinese Primary Schools: Results of a Comparative Textbook Analysis.

    Straka, Gerald A.; Bos, Wilfried


    A content analysis of selected German translations of six Chinese primary school textbooks, used from 1963 to 1982, assessed the socializing functions of qualification, integration, and identification. Categories involved include professional, moral, cultural, family, school, associations, China as a unified nation, China's achievements, and…

  15. Analysis of AGXT gene mutation in primary hyperoxaluria type I family



    Objective To describe the clinical characteristics,and to analyze the AGXT gene mutation in three siblings with primary hyperoxaluria typeⅠ(PHI).Methods AGXT gene mutation was analyzed by direct sequencing analysis in this family,and the minor allele status was also tested.One hundred unrelated healthy subjects were also analyzed as controls.Results Three mutations in

  16. Socialization Objectives of Chinese Primary Schools: Results of a Comparative Textbook Analysis.

    Straka, Gerald A.; Bos, Wilfried


    A content analysis of selected German translations of six Chinese primary school textbooks, used from 1963 to 1982, assessed the socializing functions of qualification, integration, and identification. Categories involved include professional, moral, cultural, family, school, associations, China as a unified nation, China's achievements, and…

  17. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms.

    Jonna Jalanka-Tuovinen

    Full Text Available BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce. The aim of this study was to characterize the intestinal microbiota of healthy adults and specifically address its temporal stability, core microbiota and relation with intestinal symptoms. We carried out a longitudinal study by following a set of 15 healthy Finnish subjects for seven weeks and regularly assessed their intestinal bacteria and archaea with the Human Intestinal Tract (HIT Chip, a phylogenetic microarray, in conjunction with qPCR analyses. The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point. PRINCIPAL FINDINGS: A high overall temporal stability of the microbiota was observed. Five subjects showed transient microbiota destabilization, which correlated not only with the intake of antibiotics but also with overseas travelling and temporary illness, expanding the hitherto known factors affecting the intestinal microbiota. We identified significant correlations between the microbiota and common intestinal symptoms, including abdominal pain and bloating. The most striking finding was the inverse correlation between Bifidobacteria and abdominal pain: subjects who experienced pain had over five-fold less Bifidobacteria compared to those without pain. Finally, a novel computational approach was used to define the common core microbiota, highlighting the role of the analysis depth in finding the phylogenetic core and estimating its size. The in-depth analysis suggested that we share a substantial number of our intestinal phylotypes but as they represent highly variable proportions of the total community, many of them often remain undetected. CONCLUSIONS/SIGNIFICANCE: A global and high-resolution microbiota analysis was carried out to determine the temporal stability, the associations with intestinal symptoms, and the

  18. Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots.

    Sunita Kumari

    Full Text Available Transcription initiation, essential to gene expression regulation, involves recruitment of basal transcription factors to the core promoter elements (CPEs. The distribution of currently known CPEs across plant genomes is largely unknown. This is the first large scale genome-wide report on the computational prediction of CPEs across eight plant genomes to help better understand the transcription initiation complex assembly. The distribution of thirteen known CPEs across four monocots (Brachypodium distachyon, Oryza sativa ssp. japonica, Sorghum bicolor, Zea mays and four dicots (Arabidopsis thaliana, Populus trichocarpa, Vitis vinifera, Glycine max reveals the structural organization of the core promoter in relation to the TATA-box as well as with respect to other CPEs. The distribution of known CPE motifs with respect to transcription start site (TSS exhibited positional conservation within monocots and dicots with slight differences across all eight genomes. Further, a more refined subset of annotated genes based on orthologs of the model monocot (O. sativa ssp. japonica and dicot (A. thaliana genomes supported the positional distribution of these thirteen known CPEs. DNA free energy profiles provided evidence that the structural properties of promoter regions are distinctly different from that of the non-regulatory genome sequence. It also showed that monocot core promoters have lower DNA free energy than dicot core promoters. The comparison of monocot and dicot promoter sequences highlights both the similarities and differences in the core promoter architecture irrespective of the species-specific nucleotide bias. This study will be useful for future work related to genome annotation projects and can inspire research efforts aimed to better understand regulatory mechanisms of transcription.

  19. Applying CFD in the Analysis of Heavy-Oil Transportation in Curved Pipes Using Core-Flow Technique

    S Conceição


    Full Text Available Multiphase flow of oil, gas and water occurs in the petroleum industry from the reservoir to the processing units. The occurrence of heavy oils in the world is increasing significantly and points to the need for greater investment in the reservoirs exploitation and, consequently, to the development of new technologies for the production and transport of this oil. Therefore, it is interesting improve techniques to ensure an increase in energy efficiency in the transport of this oil. The core-flow technique is one of the most advantageous methods of lifting and transporting of oil. The core-flow technique does not alter the oil viscosity, but change the flow pattern and thus, reducing friction during heavy oil transportation. This flow pattern is characterized by a fine water pellicle that is formed close to the inner wall of the pipe, aging as lubricant of the oil flowing in the core of the pipe. In this sense, the objective of this paper is to study the isothermal flow of heavy oil in curved pipelines, employing the core-flow technique. A three-dimensional, transient and isothermal mathematical model that considers the mixture and k-e  turbulence models to address the gas-water-heavy oil three-phase flow in the pipe was applied for analysis. Simulations with different flow patterns of the involved phases (oil-gas-water have been done, in order to optimize the transport of heavy oils. Results of pressure and volumetric fraction distribution of the involved phases are presented and analyzed. It was verified that the oil core lubricated by a fine water layer flowing in the pipe considerably decreases pressure drop.

  20. Primary prevention of overweight and obesity: an analysis of national survey data.

    Lutfiyya, May Nawal; Nika, Bill; Ng, Lauren; Tragos, Christina; Won, Regina; Lipsky, Martin S


    Obesity is rapidly approaching tobacco as the leading cause of preventable morbidity and mortality. Health care providers have the opportunity to address this through primary prevention strategies. To assess whether health care professionals provide primary prevention for overweight and obesity by examining the percentage of healthy-weight (body mass index [BMI] = 18.5-24.9 kg/m(2)) individuals who report being advised to maintain a healthy weight. Cross-sectional analysis of the 2003 Behavioral Risk Factor Surveillance Survey data. Noninstitutionalized U.S. adults >18 years of age. Among healthy BMI respondents, only 2.6% reported receiving primary prevention. Logistic regression analyses yielded that healthy-weight adults receiving primary prevention were more likely to report: being 18-49 years of age, annual household incomes <$35,000, having at least 1 comorbidity, having a health care provider, changed eating habits to include less fat or fewer calories, and using physical activity to maintain or lose weight. Men were also more likely to receive primary prevention. Only a very small proportion of healthy-weight adults received primary prevention, which suggests that physicians are missing opportunities to help address the epidemic of adult obesity in the US.

  1. A human factors systems approach to understanding team-based primary care: a qualitative analysis.

    Mundt, Marlon P; Swedlund, Matthew P


    Research shows that high-functioning teams improve patient outcomes in primary care. However, there is no consensus on a conceptual model of team-based primary care that can be used to guide measurement and performance evaluation of teams. To qualitatively understand whether the Systems Engineering Initiative for Patient Safety (SEIPS) model could serve as a framework for creating and evaluating team-based primary care. We evaluated qualitative interview data from 19 clinicians and staff members from 6 primary care clinics associated with a large Midwestern university. All health care clinicians and staff in the study clinics completed a survey of their communication connections to team members. Social network analysis identified key informants for interviews by selecting the respondents with the highest frequency of communication ties as reported by their teammates. Semi-structured interviews focused on communication patterns, team climate and teamwork. Themes derived from the interviews lent support to the SEIPS model components, such as the work system (Team, Tools and Technology, Physical Environment, Tasks and Organization), team processes and team outcomes. Our qualitative data support the SEIPS model as a promising conceptual framework for creating and evaluating primary care teams. Future studies of team-based care may benefit from using the SEIPS model to shift clinical practice to high functioning team-based primary care. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:

  2. Functional analysis of ultra high information rates conveyed by rat vibrissal primary afferents

    André eMaia Chagas


    Full Text Available Sensory receptors determine the type and the quantity of information available for perception. Here, we quantified and characterized the information transferred by primary afferents in the rat whisker system using neural system identification. Quantification of ‘how much’ information is conveyed by primary afferents, using the direct method, a classical information theoretic tool, revealed that primary afferents transfer huge amounts of information (up to 529 bits/s. Information theoretic analysis of instantaneous spike-triggered kinematic stimulus features was used to gain functional insight on ‘what’ is coded by primary afferents. Amongst the kinematic variables tested - position, velocity, and acceleration - primary afferent spikes encoded velocity best. The other two variables contribute to information transfer, but only if combined with velocity. We further revealed three additional characteristics that play a role in information transfer by primary afferents. Firstly, primary afferent spikes show preference for well separated multiple stimuli (i.e. well separated sets of combinations of the three instantaneous kinematic variables. Secondly, spikes are sensitive to short strips of the stimulus trajectory (up to 10 ms pre-spike time, and thirdly, they show spike patterns (precise doublet and triplet spiking. In order to deal with these complexities, we used a flexible probabilistic neuron model fitting mixtures of Gaussians to the spike triggered stimulus distributions, which quantitatively captured the contribution of the mentioned features and allowed us to achieve a full functional analysis of the total information rate indicated by the direct method. We found that instantaneous position, velocity, and acceleration explained about 50% of the total information rate. Adding a 10 ms pre-spike interval of stimulus trajectory achieved 80-90%. The final 10-20% were found to be due to non-linear coding by spike bursts.

  3. Clinicopathological features and molecular analysis of primary glioblastomas in Moroccan patients.

    Hilmani, Said; Abidi, Omar; Benrahma, Houda; Karkouri, Mehdi; Sahraoui, Souha; El Azhari, Abdessamad; Barakat, Abdelhamid


    Glioblastoma is the most frequent and most aggressive primary brain tumor. Primary and secondary glioblastomas develop through different genetic pathways. The aim of this study was to determinate the genetic and clinical features of primary glioblastoma in Moroccan patients. The blood and tumor samples were obtained from a group of 34 Moroccan patients affected with primary glioblastoma. The tumors were investigated for TP53, IDH1, and IDH2 mutations using PCR sequencing analysis. Clinicopathological data showed that the mean age at diagnosis of patients was 50.06 years, the sex ratio was 11 F/23 M, and the median of Karnofsky performance score was 60. About 18 % of patients were initially treated by total tumor resection, 41 % by subtotal, and 38 % by partial resection, but biopsy was performed for a single patient (3 %). Twenty-five patients (74 %) received radiotherapy. In addition, the median survival of the all patients was 13 months following diagnosis. There was a significant impact of higher Karnofsky performance score (KPS) (≥80) on overall survival, p-log-rank test = 0.0002, whereas other parameters did not show any significant differences. The molecular analysis revealed TP53 mutations in 3/34 (8.82 %) cases; R273H, R306X, and Q136X. However, none of the analyzed samples contained the R132-IDH1 or R172-IDH2 mutations. These results showed the absence of IDH1 mutation in primary glioblastoma, confirming that this mutation is a hallmark of secondary glioblastoma. It can be used to distinguish primary from secondary glioblastomas. We found also that higher KPS was a significantly favorable factor in patients with primary glioblastoma.

  4. Spatial and temporal gene expression differences in core and periinfarct areas in experimental stroke: a microarray analysis.

    Jaime Ramos-Cejudo

    Full Text Available BACKGROUND: A large number of genes are regulated to promote brain repair following stroke. The thorough analysis of this process can help identify new markers and develop therapeutic strategies. This study analyzes gene expression following experimental stroke. METHODOLOGY/PRINCIPAL FINDINGS: A microarray study of gene expression in the core, periinfarct and contralateral cortex was performed in adult Sprague-Dawley rats (n = 60 after 24 hours (acute phase or 3 days (delayed stage of permanent middle cerebral artery (MCA occlusion. Independent qRT-PCR validation (n = 12 was performed for 22 of the genes. Functional data were evaluated by Ingenuity Pathway Analysis. The number of genes differentially expressed was 2,612 (24 h and 5,717 (3 d in the core; and 3,505 (24 h and 1,686 (3 d in the periinfarct area (logFC>|1|; adjP<0.05. Expression of many neurovascular unit development genes was altered at 24 h and 3 d including HES2, OLIG2, LINGO1 and NOGO-A; chemokines like CXCL1 and CXCL12, stress-response genes like HIF-1A, and trophic factors like BDNF or BMP4. Nearly half of the detected genes (43% had not been associated with stroke previously. CONCLUSIONS: This comprehensive study of gene regulation in the core and periinfarct areas at different times following permanent MCA occlusion provides new data that can be helpful in translational research.

  5. "An Easy Switch": A Descriptive Case Study Exploring the Shift toward Informational Text Accompanying the Implementation of Common Core State Standards in Five Primary Classrooms

    Kindall, Heather


    The purpose of this descriptive case study was to discover how the newly implemented Common Core State Standards (CCSS) may have changed teachers' practices and philosophies regarding literacy instruction and to determine which teaching strategies were being presented in regard to informational text in the studied Kindergarten through second grade…

  6. Code assessment and modelling for Design Basis Accident analysis of the European Sodium Fast Reactor design. Part II: Optimised core and representative transients analysis

    Lazaro, A., E-mail: [JRC-IET European Commission, Westerduinweg 3, PO BOX 2, 1755 ZG Petten (Netherlands); Schikorr, M. [KIT, Institute for Neutron Physics and Reactor Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Mikityuk, K. [PSI, Paul Scherrer Institut, 5232 Villigen (Switzerland); Ammirabile, L. [JRC-IET European Commission, Westerduinweg 3, PO BOX 2, 1755 ZG Petten (Netherlands); Bandini, G. [ENEA, Via Martiri di Monte Sole 4, 40129 Bologna (Italy); Darmet, G.; Schmitt, D. [EDF, 1 Avenue du Général de Gaulle, 92141 Clamart (France); Dufour, Ph.; Tosello, A. [CEA, St. Paul lez Durance, 13108 Cadarache (France); Gallego, E.; Jimenez, G. [UPM, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Bubelis, E.; Ponomarev, A.; Kruessmann, R.; Struwe, D. [KIT, Institute for Neutron Physics and Reactor Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Stempniewicz, M. [NRG, Utrechtseweg 310, P.O. Box-9034, 6800 ES Arnhem (Netherlands)


    Highlights: • Benchmarked models have been applied for the analysis of DBA transients of the ESFR design. • Two system codes are able to simulate the behavior of the system beyond sodium boiling. • The optimization of the core design and its influence in the transients’ evolution is described. • The analysis has identified peak values and grace times for the protection system design. - Abstract: The new reactor concepts proposed in the Generation IV International Forum require the development and validation of computational tools able to assess their safety performance. In the first part of this paper the models of the ESFR design developed by several organisations in the framework of the CP-ESFR project were presented and their reliability validated via a benchmarking exercise. This second part of the paper includes the application of those tools for the analysis of design basis accident (DBC) scenarios of the reference design. Further, this paper also introduces the main features of the core optimisation process carried out within the project with the objective to enhance the core safety performance through the reduction of the positive coolant density reactivity effect. The influence of this optimised core design on the reactor safety performance during the previously analysed transients is also discussed. The conclusion provides an overview of the work performed by the partners involved in the project towards the development and enhancement of computational tools specifically tailored to the evaluation of the safety performance of the Generation IV innovative nuclear reactor designs.

  7. Application Performance Analysis and Efficient Execution on Systems with multi-core CPUs, GPUs and MICs: A Case Study with Microscopy Image Analysis.

    Teodoro, George; Kurc, Tahsin; Andrade, Guilherme; Kong, Jun; Ferreira, Renato; Saltz, Joel


    We carry out a comparative performance study of multi-core CPUs, GPUs and Intel Xeon Phi (Many Integrated Core-MIC) with a microscopy image analysis application. We experimentally evaluate the performance of computing devices on core operations of the application. We correlate the observed performance with the characteristics of computing devices and data access patterns, computation complexities, and parallelization forms of the operations. The results show a significant variability in the performance of operations with respect to the device used. The performances of operations with regular data access are comparable or sometimes better on a MIC than that on a GPU. GPUs are more efficient than MICs for operations that access data irregularly, because of the lower bandwidth of the MIC for random data accesses. We propose new performance-aware scheduling strategies that consider variabilities in operation speedups. Our scheduling strategies significantly improve application performance compared to classic strategies in hybrid configurations.

  8. KUGEL: a thermal, hydraulic, fuel performance, and gaseous fission product release code for pebble bed reactor core analysis

    Shamasundar, B.I.; Fehrenbach, M.E.


    The KUGEL computer code is designed to perform thermal/hydraulic analysis and coated-fuel particle performance calculations for axisymmetric pebble bed reactor (PBR) cores. This computer code was developed as part of a Department of Energy (DOE)-funded study designed to verify the published core performance data on PBRs. The KUGEL code is designed to interface directly with the 2DB code, a two-dimensional neutron diffusion code, to obtain distributions of thermal power, fission rate, fuel burnup, and fast neutron fluence, which are needed for thermal/hydraulic and fuel performance calculations. The code is variably dimensioned so that problem size can be easily varied. An interpolation routine allows variable mesh size to be used between the 2DB output and the two-dimensional thermal/hydraulic calculations.

  9. Radiocarbon analysis of the EPICA Dome C ice core: no in situ {sup 14}C from the firn observed

    Jong, A.F.M. de; Alderliesten, C.; Borg, K. van der E-mail:; Veen, C. van der; Wal, R.S.W. van de


    CO{sub 2} and CO obtained by dry-extraction from ice samples of the EPICA Dome C core were {sup 14}C analysed by AMS. For some of the ice samples there is no evidence for in situ {sup 14}C, indicating the firn did not retain {sup 14}C. The {sup 14}C ages of these samples are too old in comparison with a calibrated ice-flow model, and the concentrations of {sup 14}CO are near zero. For other ice samples, however, in situ {sup 14}C is clearly present, and is likely from post-coring exposure at the Dome C surface. These samples show too young {sup 14}C ages, and distinct concentrations of {sup 14}CO. The accuracy of ages obtained from {sup 14}C analysis of ice samples is discussed.

  10. Ray-tracing analysis of crosstalk in multi-core polymer optical fibers.

    Berganza, Amaia; Aldabaldetreku, Gotzon; Zubia, Joseba; Durana, Gaizka


    The aim of this paper is to present a new ray-tracing model which describes the propagation of light in multi-core polymer optical fibers (MCPOFs), taking into account the crosstalk among their cores. The new model overcomes many of the limitations of previous approaches allowing us to simulate MCPOFs of arbitrary designs. Additionally, it provides us with the output ray distribution at the end of the fiber, making it possible to calculate useful parameters related to the fiber performance such as the Near-Field Pattern, the Far-Field Pattern or the bandwidth. We also present experimental measurements in order to validate the computational model and we analyze the importance of crosstalk in different MCPOF configurations.

  11. Monte Carlo Error Analysis Applied to Core Formation: The Single-stage Model Revived

    Cottrell, E.; Walter, M. J.


    The last decade has witnessed an explosion of studies that scrutinize whether or not the siderophile element budget of the modern mantle can plausibly be explained by metal-silicate equilibration in a deep magma ocean during core formation. The single-stage equilibrium scenario is seductive because experiments that equilibrate metal and silicate can then serve as a proxy for the early earth, and the physical and chemical conditions of core formation can be identified. Recently, models have become more complex as they try to accommodate the proliferation of element partitioning data sets, each of which sets its own limits on the pressure, temperature, and chemistry of equilibration. The ability of single stage models to explain mantle chemistry has subsequently been challenged, resulting in the development of complex multi-stage core formation models. Here we show that the extent to which extant partitioning data are consistent with single-stage core formation depends heavily upon (1) the assumptions made when regressing experimental partitioning data (2) the certainty with which regression coefficients are known and (3) the certainty with which the core/mantle concentration ratios of the siderophile elements are known. We introduce a Monte Carlo algorithm coded in MATLAB that samples parameter space in pressure and oxygen fugacity for a given mantle composition (nbo/t) and liquidus, and returns the number of equilibrium single-stage liquidus “solutions” that are permissible, taking into account the uncertainty in regression parameters and range of acceptable core/mantle ratios. Here we explore the consequences of regression parameter uncertainty and the impact of regression construction on model outcomes. We find that the form of the partition coefficient (Kd with enforced valence state, or D) and the handling of the temperature effect (based on 1-atm free energy data or high P-T experimental observations) critically affects model outcomes. We consider the most

  12. Performance Analysis for EDMA Based on TIC6678Multi-core DSP

    Yun Xu; Yimin Ouyang; Renjie Niu


    Frequent data exchange among all kinds of memories has become an inevitable phenomenon in the process of modern embeddedsoftware design. In order to improve the ability of the embedded system data's throughput and computation, most embeddeddevices introduce Enhanced Direct Memory Access (EDMA) data transfer technology. TMS320C6678 is a multi-core DSPproduced by Texas Instruments (TI). There are ten EDMA transmission controllers in the chip for configuration and datatransmissions are allowed to be performed between any two pieces of storage at the same time. This paper expounds the workingmechanism of EDMA based on multi-core DSP TMS320C6678. At the same time, multiple data sets are provided and thebottleneck of limiting data throughout is analyzed and solved.

  13. Thermal-hydraulic analysis techniques for axisymmetric pebble bed nuclear reactor cores. [PEBBLE code

    Stroh, K.R.


    The pebble bed reactor's cylindrical core volume contains a random bed of small, spherical fuel-moderator elements. These graphite spheres, containing a central region of dispersed coated-particle fissile and fertile material, are cooled by high pressure helium flowing through the connected interstitial voids. A mathematical model and numerical solution technique have been developed which allow calculation of macroscopic values of thermal-hydraulic variables in an axisymmetric pebble bed nuclear reactor core. The computer program PEBBLE is based on a mathematical model which treats the bed macroscopically as a generating, conducting porous medium. The steady-state model uses a nonlinear Forchheimer-type relation between the coolant pressure gradient and mass flux, with newly derived coefficients for the linear and quadratic resistance terms. The remaining equations in the model make use of mass continuity, and thermal energy balances for the solid and fluid phases.

  14. Analysis of reactivity characteristics of the MONJU initial core using JENDL-3.2

    Sasaki, Kenji; Suzuki, Takayuki; Suzuki, Norimichi [Power Reactor and Nuclear Fuel Development Corp., Tsuruga, Fukui (Japan). Monju Construction Office; Itagaki, Yoshihiko


    This paper describes the evaluated results of criticality, absorber rod worth and coolant worth in the MONJU initial cores based on the JENDL-3.2 library compared with those of the JENDL-2 library. We confirm that the ratios of calculated and experimental (C/E) values using the JENDL-3.2 library are slightly better than those based on the JENDL-2 library. (author)

  15. Development of a Chemical Equilibrium Model for a Molten Core-Concrete Interaction Analysis Module

    Seo, Jae Uk; Lee, Dae Young; Park, Chang Hwan [FNC Technology Co., Yongin (Korea, Republic of)


    This molten core could interact with the reactor cavity region which consists of concrete. In this process, components of molten core react with components of concrete through a lot of chemical reactions. As a result, many kinds of gas species are generated and those move up forming rising bubbles into the reactor containment atmosphere. These rising bubbles are the carrier of the many kinds of the aerosols coming from the MCCI (Molten Core Concrete Interaction) layers. To evaluate the amount of the aerosols released from the MCCI layers, the amount of the gas species generated from those layers should be calculated. The chemical equilibrium state originally implies the final state of the multiple chemical reactions; therefore, investigating the equilibrium composition of molten core can be applicable to predict the gas generation status. The most common way for finding the chemical equilibrium state is a minimization of total Gibbs free energy of the system. In this paper, the method to make good guess of initial state is suggested and chemical reaction results are compared with results of CSSI report No 164. Total mass of system and the number of atoms of each element are conserved. The tendency of calculation results is similar with results presented in CSNI Report except a few species. These differences may be caused by absence of Gibbs energy data of the species such as Fe{sub 2}SiO{sub 4}, CaFe{sub 2}O{sub 4}, U(OH){sub 3}, UO(OH), UO{sub 2}(OH), U{sub 3}O{sub 7}, La, Ce.

  16. Three-Dimensional Thermal Analysis of 18-Core Photonic Crystal Fiber Lasers

    ZHENG Yi-Bo; YAO Jian-Quan; ZHANG Lei; WANG Yuan; WEN Wu-Qi; JING Lei; DI Zhi-Gang


    The three-dimensional thermal properties of 18-core photonic crystal fiber lasers operated under natural convection are investigated. The temperature sensing technique based on a fiber Bragg grating sensor array is proposed to measure the longitudinal temperature distribution of a 1.6-m-long ytterbium-doped 18-core photonic crystal fiber. The results show that the temperature decreases from the pump end to the launch end exponentially. Moreover, the radial temperature distribution of the fiber end is investigated by using the full-vector finite-element method. The numerical results match well with the experimental data and the coating temperature reaches 422.7K, approaching the critical value of polymer cladding, when the pumping power is 40 W. Therefore the fiber end cooling is necessary to achieve power scaling. Compared with natural convection methods, the copper cooling scheme is found to be an effective method to reduce the fiber temperature.%The three-dimensional thermal properties of 18-core photonic crystal fiber lasers operated under natural convection are investigated.The temperature sensing technique based on a fiber Bragg grating sensor array is proposed to measure the longitudinal temperature distribution of a 1.6-m-long ytterbium-doped 18-core photonic crystal fiber.The results show that the temperature decreases from the pump end to the launch end exponentially.Moreover,the radial temperature distribution of the fiber end is investigated by using the full-vector finite-element method.The numerical results match well with the experimental data and the coating temperature reaches 422.7K,approaching the critical value of polymer cladding,when the pumping power is 40 W.Therefore the fiber end cooling is necessary to achieve power scaling.Compared with natural convection methods,the copper cooling scheme is found to be an effective method to reduce the fiber temperature.

  17. Implementation of Preconditioned Krylov Subspace Method in MATRA Code for Whole Core Analysis of SMART

    Kwon, Hyuk; Kim, S. J.; Park, J. P.; Hwang, D. H. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    Krylov subspace method was implemented to perform the efficient whole core calculation of SMART with pin by pin subchannel model without lumping channel. The SMART core consisted of 57 fuel assemblies of 17 by 17 arrays with 264 fuel rods and 25 guide tubes and there are total 15,048 fuel rods and 16,780 subchannels. Restarted GMRES and BiCGStab methods are selected among Krylov subspace methods. For the purpose of verifying the implementation of Krylov method, whole core problem is considered under the normal operating condition. In this problem, solving a linear system Aχ = b is considered when A is nearly symmetric and when the system is preconditioned with incomplete LU factorization(ILU). The preconditioner using incomplete LU factorization are among the most effective preconditioners for solving general large, sparse linear systems arising from practical engineering problem. The Krylov subspace method is expected to improve the calculation effectiveness of MATRA code rather than direct method and stationary iteration method such as Gauss elimination and SOR. The present study describes the implementation of Krylov subspace methods with ILU into MATRA code. In this paper, we explore an improved performance of MATRA code for the SMART whole core problems by of Krylov subspace method. For this purpose, two preconditioned Krylov subspace methods, GMRES and BiCGStab, are implemented into the subchannel code MATRA. A typical ILU method is used as the preconditioner. Numerical problems examined in this study indicate that the Krylov subspace method shows the outstanding improvements in the calculation speed and easy convergence.

  18. Cobinamide-Based Cyanide Analysis by Multiwavelength Spectrometry in a Liquid Core Waveguide

    Ma, Jian; Dasgupta, Purnendu K.; Blackledge, William; Boss, Gerry R.


    A novel cyanide analyzer based on sensitive cobinamide chemistry relies on simultaneous reagent and sample injection and detection in a 50 cm liquid core waveguide (LCW) flow cell illuminated by a white light emitting diode. The transmitted light is read by a fiber-optic charge coupled device (CCD) spectrometer. Alkaline cobinamide (orange, λmax = 510 nm) changes to violet (λmax = 583 nm) upon reaction with cyanide. Multiwavelength detection permits built-in correction for artifact responses ...

  19. Continuous flow analysis method for determination of dissolved reactive phosphorus in ice cores.

    Kjær, Helle Astrid; Vallelonga, Paul; Svensson, Anders; Kristensen, Magnus Elleskov L; Tibuleac, Catalin; Bigler, Matthias


    Phosphorus (P) is an essential macronutrient for all living organisms. Phosphorus is often present in nature as the soluble phosphate ion PO4(3-) and has biological, terrestrial, and marine emission sources. Thus PO4(3-) detected in ice cores has the potential to be an important tracer for biological activity in the past. In this study a continuous and highly sensitive absorption method for detection of dissolved reactive phosphorus (DRP) in ice cores has been developed using a molybdate reagent and a 2-m liquid waveguide capillary cell (LWCC). DRP is the soluble form of the nutrient phosphorus, which reacts with molybdate. The method was optimized to meet the low concentrations of DRP in Greenland ice, with a depth resolution of approximately 2 cm and an analytical uncertainty of 1.1 nM (0.1 ppb) PO4(3-). The method has been applied to segments of a shallow firn core from Northeast Greenland, indicating a mean concentration level of 2.74 nM (0.26 ppb) PO4(3-) for the period 1930-2005 with a standard deviation of 1.37 nM (0.13 ppb) PO4(3-) and values reaching as high as 10.52 nM (1 ppb) PO4(3-). Similar levels were detected for the period 1771-1823. Based on impurity abundances, dust and biogenic particles were found to be the most likely sources of DRP deposited in Northeast Greenland.

  20. Harmonic Differential Quadrature Analysis of Soft-Core Sandwich Panels under Locally Distributed Loads

    Xinwei Wang


    Full Text Available Sandwich structures are widely used in practice and thus various engineering theories adopting simplifying assumptions are available. However, most engineering theories of beams, plates and shells cannot recover all stresses accurately through their constitutive equations. Therefore, the soft-core is directly modeled by two-dimensional (2D elasticity theory without any pre-assumption on the displacement field. The top and bottom faces act like the elastic supports on the top and bottom edges of the core. The differential equations of the 2D core are then solved by the harmonic differential quadrature method (HDQM. To circumvent the difficulties in dealing with the locally distributed load by point discrete methods such as the HDQM, a general and rigorous way is proposed to treat the locally distributed load. Detailed formulations are provided. The static behavior of sandwich panels under different locally distributed loads is investigated. For verification, results are compared with data obtained by ABAQUS with very fine meshes. A high degree of accuracy on both displacement and stress has been observed.

  1. Third Generation (3G) Site Characterization: Cryogenic Core Collection and High Throughput Core Analysis - An Addendum to Basic Research Addressing Contaminants in Low Permeability Zones - A State of the Science Review


    samples A = microbiological analysis B = methanol extraction C = water extraction 4.3 Analytical Methods 4.3.1 Biological Analysis For... microbiological analysis, half of each sample disk was wrapped in aluminum foil and returned to the freezer (-80°C) until DNA extraction. Note low DNA...are not available for unfrozen core (e.g., chopping into 1-inch “hockey pucks” and sectioning those disks into quarters with a sterile chisel). 6.1.6

  2. Theoretical Analysis of Tunable Single-Core Comb Filter Based on MZI

    J. N. Sikta


    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE In this work, a theoretical analysis of single core tunable comb filter based on Mach-Zehnder (M-Z interferometer is proposed and demonstrated. The proposed filter consists of one QWP, one HWP, one SMF and onePMF segment consists of two PMF lengths. Depending on the dynamic settings of wavelength of the input

  3. Initial Comparison of Direct and Legacy Modeling Approaches for Radial Core Expansion Analysis

    Shemon, Emily R. [Argonne National Lab. (ANL), Argonne, IL (United States)


    Radial core expansion in sodium-cooled fast reactors provides an important reactivity feedback effect. As the reactor power increases due to normal start up conditions or accident scenarios, the core and surrounding materials heat up, causing both grid plate expansion and bowing of the assembly ducts. When the core restraint system is designed correctly, the resulting structural deformations introduce negative reactivity which decreases the reactor power. Historically, an indirect procedure has been used to estimate the reactivity feedback due to structural deformation which relies upon perturbation theory and coupling legacy physics codes with limited geometry capabilities. With advancements in modeling and simulation, radial core expansion phenomena can now be modeled directly, providing an assessment of the accuracy of the reactivity feedback coefficients generated by indirect legacy methods. Recently a new capability was added to the PROTEUS-SN unstructured geometry neutron transport solver to analyze deformed meshes quickly and directly. By supplying the deformed mesh in addition to the base configuration input files, PROTEUS-SN automatically processes material adjustments including calculation of region densities to conserve mass, calculation of isotopic densities according to material models (for example, sodium density as a function of temperature), and subsequent re-homogenization of materials. To verify the new capability of directly simulating deformed meshes, PROTEUS-SN was used to compute reactivity feedback for a series of contrived yet representative deformed configurations for the Advanced Burner Test Reactor design. The indirect legacy procedure was also performed to generate reactivity feedback coefficients for the same deformed configurations. Interestingly, the legacy procedure consistently overestimated reactivity feedbacks by 35% compared to direct simulations by PROTEUS-SN. This overestimation indicates that the legacy procedures are in fact

  4. Design and Coupled Thermo-Mechanical Analysis of Silicon Carbide Primary Mirror Assembly

    HAN Yuan-yuan; ZHANG Yu-min; HAN Jie-cai


    Based on the principle that the thermal expansion coefficient of the support structure should match that of the mirror, three schemes of primary mirror assembly were designed. Of them, the first is fused silica mirror plus 4J32 flexible support plus ZTC4 support back plate, the second K9 mirror plus 4J45 flexible support plus ZTC4 support back plate, and the third SiC mirror plus SiC rigid support back plate. A coupled thermo-mechanical analysis of the three primary mirror assemblies was made with finite element method. The results show that the SiC assembly is the best of all schemes in terms of their combination properties due to its elimination of the thermal expansion mismatch between the materials. The analytical results on the cryogenic property of the SiC primary mirror assembly show a higher surface finish of the SiC mirror even under the cryogenic condition.

  5. Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes

    Upton Chris


    Full Text Available Abstract Background Members of the family Iridoviridae can cause severe diseases resulting in significant economic and environmental losses. Very little is known about how iridoviruses cause disease in their host. In the present study, we describe the re-analysis of the Iridoviridae family of complex DNA viruses using a variety of comparative genomic tools to yield a greater consensus among the annotated sequences of its members. Results A series of genomic sequence comparisons were made among, and between the Ranavirus and Megalocytivirus genera in order to identify novel conserved ORFs. Of these two genera, the Megalocytivirus genomes required the greatest number of altered annotations. Prior to our re-analysis, the Megalocytivirus species orange-spotted grouper iridovirus and rock bream iridovirus shared 99% sequence identity, but only 82 out of 118 potential ORFs were annotated; in contrast, we predict that these species share an identical complement of genes. These annotation changes allowed the redefinition of the group of core genes shared by all iridoviruses. Seven new core genes were identified, bringing the total number to 26. Conclusion Our re-analysis of genomes within the Iridoviridae family provides a unifying framework to understand the biology of these viruses. Further re-defining the core set of iridovirus genes will continue to lead us to a better understanding of the phylogenetic relationships between individual iridoviruses as well as giving us a much deeper understanding of iridovirus replication. In addition, this analysis will provide a better framework for characterizing and annotating currently unclassified iridoviruses.

  6. Thermal Analysis of the Advanced Technology Large Aperture Space Telescope (ATLAST) 8 Meter Primary Mirror

    Hornsby, Linda; Stahl, H. Philip; Hopkins, Randall C.


    The Advanced Technology Large Aperture Space Telescope (ATLAST) preliminary design concept consists of an 8 meter diameter monolithic primary mirror enclosed in an insulated, optical tube with stray light baffles and a sunshade. ATLAST will be placed in orbit about the Sun-Earth L2 and will experience constant exposure to the sun. The insulation on the optical tube and sunshade serve to cold bias the telescope which helps to minimize thermal gradients. The primary mirror will be maintained at 280K with an active thermal control system. The geometric model of the primary mirror, optical tube, sun baffles, and sunshade was developed using Thermal Desktop(R) SINDA/FLUINT(R) was used for the thermal analysis and the radiation environment was analyzed using RADCAD(R). A XX node model was executed in order to characterize the static performance and thermal stability of the mirror during maneuvers. This is important because long exposure observations, such as extra-solar terrestrial planet finding and characterization, require a very stable observatory wave front. Steady state thermal analyses served to predict mirror temperatures for several different sun angles. Transient analyses were performed in order to predict thermal time constant of the primary mirror for a 20 degree slew or 30 degree roll maneuver. This paper describes the thermal model and provides details of the geometry, thermo-optical properties, and the environment which influences the thermal performance. All assumptions that were used in the analysis are also documented. Parametric analyses are summarized for design parameters including primary mirror coatings and sunshade configuration. Estimates of mirror heater power requirements are reported. The thermal model demonstrates results for the primary mirror heated from the back side and edges using a heater system with multiple independently controlled zones.

  7. Primary and secondary cases in Escherichia coli O157 outbreaks: a statistical analysis

    Shaw Darren J


    Full Text Available Abstract Background Within outbreaks of Escherichia coli O157 (E. coli O157, at least 10–15% of cases are thought to have been acquired by secondary transmission. However, there has been little systematic quantification or characterisation of secondary outbreak cases worldwide. The aim of this study was to characterise secondary outbreak cases, estimate the overall proportion of outbreak cases that were the result of secondary transmission and to analyse the relationships between primary and secondary outbreak cases by mode of transmission, country and median age. Methods Published data was obtained from 90 confirmed Escherichia coli O157 outbreaks in Great Britain, Ireland, Scandinavia, Canada, the United States and Japan, and the outbreaks were described in terms of modes of primary and secondary transmission, country, case numbers and median case age. Outbreaks were tested for statistically significant differences in the number of ill, confirmed, primary and secondary cases (analysis of variance and Kruskal-Wallis and in the rate of secondary cases between these variables (Generalised Linear Models. Results The outbreaks had a median of 13.5 confirmed cases, and mean proportion of 0.195 secondary cases. There were statistically significant differences in the numbers of ill, confirmed, primary and secondary cases between modes of primary transmission (p Secondary case rates differed statistically significantly between modes of secondary and primary transmission and median age categories (all p Conclusion Our analyses indicated that ~20% of E. coli O157 outbreak cases were the result of secondary spread, and that this spread is significantly influenced by age and modes of primary and secondary transmission, but not country. In particular, the results provide further data emphasising the importance of simple but effective preventive strategies, such as handwashing, that can reduce the risk of secondary spread, particularly amongst young

  8. A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: A systematic review and meta-analysis.

    Wang, Mei; He, Xiaoning; Chang, Yaping; Sun, Guangwen; Thabane, Lehana


    Breast cancer detections for women with suspicious lesions mainly depend on two non-operative pathological tests-fine needle aspiration cytology (FNAC) and core needle biopsy (CNB). The aim of this systematic review was to compare the sensitivity and specificity of CNB and FNAC in this setting. The data sources included MEDLINE, EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials (CENTRAL) till February 2016. We included prospective series of studies which directly compared the accuracy of FNAC and CNB. We used forest plots to display the sensitivity and specificity of FNAC and CNB respectively. Pre-specified subgroup analyses and sensitivity analysis were conducted. Ultimately, 12 articles (1802 patients) were included in the final analysis. The pooled analysis shows that the sensitivity of CNB is better than that of FNAC [87% (95% CI, 84%-88%, I(2) = 88.5%) versus 74% (95% CI, 72%-77%, I(2) = 88.3%)] and the specificity of CNB is similar to that of FNAC [98% (95% CI, 96%-99%, I(2) = 76.2%) versus 96% (95% CI, 94%-98%, I(2) = 39.0%)]. For subgroup analysis, the sensitivities of both tests are better for palpable lesions than that of non-palpable lesions. Sensitivity analysis shows the robustness of the primary analysis. Our study suggests that both of FNAC and CNB have good clinical performance. In similar circumstances, the sensitivity of CNB is better than that of FNAC, while their specificities are similar. FNAC could be still considered the first choice to evaluate suspicious nonpalpable breast lesions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Comparative Analysis on the Primary English Curricula of Japan and Indonesia

    T Tuswadi


    Full Text Available Abstract Primary English education in Indonesia and Japan is developing rapidly nowadays. Children in both countries have started to learn  English since they are at least in grade four or five. Although English is not a compulsory subject in primary schools, the interest of schools in the two countries toward English education for children is getting higher. This paper tried to reveal the similarities and differences of primary English curiculum  contents in Indonesia and in Japan in order to understand better about the development of English education in primary schools in the two countries. Abstrak Pendidikan bahasa Inggris dasar di Indonesia dan Jepang berkembang pesat saat ini. Anak-anak di kedua negara tersebut sudah mulai belajar bahasa Inggris setidaknya sejak mereka kelas empat atau kelas lima. Meskipun bahasa Inggris bukan mata pelajaran wajib di sekolah dasar, minat sekolah-sekolah di kedua negara terhadap pendidikan bahasa Inggris untuk anak-anak semakin tinggi. Tulisan ini mencoba untuk mengungkapkan persamaan dan perbedaan isi kurikulum bahasa Inggris dasar di Indonesia dan di Jepang untuk memahami lebih baik tentang perkembangan pendidikan bahasa Inggris di tingkat sekolah dasar di kedua negara. How to Cite : Tuswadi. (2016. Comparative Analysis of the Primary English Curricula of Japan and Indonesia. TARBIYA: Journal Of Education In Muslim Society, 3(1, 96-106. doi:10.15408/tjems.v3i1.3224. Permalink/DOI:

  10. Direct ChromOSOme Analysis and FISH Detection of Primary Gastric cancer


    Objective: To investigate chromosome aberrations and their role in the genesis and development of primary gastric cancer. Methods: An improved, direct chromosome preparation from solid tumors was adopted for G-banding analysis followed by FISH on decolored G-banding chromosomes so that chromosome aberrations could be confirmed at DNA level. Results: A total of 28 primary gastric cancer specimens were studies. Case 1 and case 2 had simple chromosome numerical changes: 49, XY, +2, +8, +9 and 48, +8, +20, respectively. All but case 1 and 2 had complicated chromosome abnormalities. Chromosome structural of frequent occurrence involved del(7q)(21/26), del(3p)(14/26), del(lp)(l1/26) and del(17p)(10/26). The chromosome abnormalities could be simple and complicated. In former, numerical changes involving 1 to 3 chromosome could be observed. Trisomies 8 and 9 might represent a cytogenetic subgroup of primary gastric cancer. In the later, the del(7q) was the most consistent aberration. 7q32-qter was the commonly lost segment. Conclusion: Numerical and structural alterations of chromosomes are present in primary gastric cancer. Del(7q) is one of the structural change characteristic of primary gastric cancer. In the 7q32-qter fragment, a tumor suppressor gene probably exists and it may have close relation to the genesis and progression of gastric cancer.

  11. Thermal Hydraulics Design and Analysis Methodology for a Solid-Core Nuclear Thermal Rocket Engine Thrust Chamber

    Wang, Ten-See; Canabal, Francisco; Chen, Yen-Sen; Cheng, Gary; Ito, Yasushi


    Nuclear thermal propulsion is a leading candidate for in-space propulsion for human Mars missions. This chapter describes a thermal hydraulics design and analysis methodology developed at the NASA Marshall Space Flight Center, in support of the nuclear thermal propulsion development effort. The objective of this campaign is to bridge the design methods in the Rover/NERVA era, with a modern computational fluid dynamics and heat transfer methodology, to predict thermal, fluid, and hydrogen environments of a hypothetical solid-core, nuclear thermal engine the Small Engine, designed in the 1960s. The computational methodology is based on an unstructured-grid, pressure-based, all speeds, chemically reacting, computational fluid dynamics and heat transfer platform, while formulations of flow and heat transfer through porous and solid media were implemented to describe those of hydrogen flow channels inside the solid24 core. Design analyses of a single flow element and the entire solid-core thrust chamber of the Small Engine were performed and the results are presented herein

  12. Physical Analysis of the Initial Core and Running-In Phase for Pebble-Bed Reactor HTR-PM

    Jingyu Zhang


    Full Text Available The pebble-bed reactor HTR-PM is being built in China and is planned to be critical in one or two years. At present, one emphasis of engineering design is to determine the fuel management scheme of the initial core and running-in phase. There are many possible schemes, and many factors need to be considered in the process of scheme evaluation and analysis. Based on the experience from the constructed or designed pebble-bed reactors, the fuel enrichment and the ratio of fuel spheres to graphite spheres are important. In this paper, some relevant physical considerations of the initial core and running-in phase of HTR-PM are given. Then a typical scheme of the initial core and running-in phase is proposed and simulated with VSOP code, and some key physical parameters, such as the maximum power per fuel sphere, the maximum fuel temperature, the refueling rate, and the discharge burnup, are calculated. Results of the physical parameters all satisfy the relevant design requirements, which means the proposed scheme is safe and reliable and can provide support for the fuel management of HTR-PM in the future.

  13. Identifying regions of strong scattering at the core-mantle boundary from analysis of PKKP precursor energy

    Rost, S.; Earle, P.S.


    We detect seismic scattering from the core-mantle boundary related to the phase PKKP (PK. KP) in data from small aperture seismic arrays in India and Canada. The detection of these scattered waves in data from small aperture arrays is new and allows a better characterization of the fine-scale structure of the deep Earth especially in the southern hemisphere. Their slowness vector is determined from array processing allowing location of the heterogeneities at the core-mantle boundary using back-projection techniques through 1D Earth models. We identify strong scattering at the core-mantle boundary (CMB) beneath the Caribbean, Patagonia and the Antarctic Peninsula as well as beneath southern Africa. An analysis of the scattering regions relative to sources and receivers indicates that these regions represent areas of increased scattering likely due to increased heterogeneities close to the CMB. The 1. Hz array data used in this study is most sensitive to heterogeneity with scale lengths of about 10. km. Given the small size of the scatterers, a chemical origin of the heterogeneities is likely. By comparing the location of the fine-scale heterogeneity to geodynamical models and tomographic images, we identify different scattering mechanisms in regions related to subduction (Caribbean and Patagonia) and dense thermo chemical piles (Southern Africa). ?? 2010 Elsevier B.V.

  14. A novel periodic macrobending hetero-core fiber optic sensor embedded in textile for respiratory movements' analysis

    Alemdar, Kubra; Likoglu, Sumeyra; Fidanboylu, Kemal; Toker, Onur


    This paper presents the design of a novel periodic macrobending hetero-core fiber optic sensor embedded in textile for respiratory movements' analysis. We report on several different designs based on textiles which have different loop periodicity and configuration of optical fiber types. In all experiments, the changes of textile elongation are measured during breathing movements. In order to demonstrate the superiority of the proposed sensor, experiments were done on a macrobending sensor constructed from 62.5-50-62.5 hetero-core fiber and a macrobending sensor constructed from 62.5/125 μm multi-mode fiber having different loops. Experimental results show that the sensitivity of the proposed macrobending sensor constructed using hetero-core optical fiber is much higher than the sensor constructed from plain multi-mode optical fiber. It is also shown that, the sensitivity of the sensor increases as the number of loops is increased. On the other hand, several experiments were performed for periodic macrobending sensors having different bending radius by changing the lengths of loops amplitude and period. We demonstrate that the sensors tested on different patients' morphology can successfully sense respiratory movements.

  15. Thermo-mechanical interaction effects in foam cored sandwich panels-correlation between High-order models and Finite element analysis results

    Palleti, Hara Naga Krishna Teja; Santiuste, Carlos; Thomsen, Ole Thybo;


    Thermo-mechanical interaction effects including thermal material degradation in polymer foam cored sandwich structures is investigated using the commercial Finite Element Analysis (FEA) package ABAQUS/Standard. Sandwich panels with different boundary conditions in the form of simply supported...

  16. High-Resolution Magnetostratigraphic Analysis of the Denver Basin Kiowa Core; Testing Paleocene Astrochronologies

    Jones, M. M.; Clyde, W. C.; Bowring, S. A.; Ramezani, J.; Johnson, K. R.


    Marine records of orbitally driven climate cycles have been used to create an astronomically calibrated timescale for the Neogene Period (0-23 Ma). Recent studies have attempted to extend this approach to the Paleogene Period (23-65 Ma), despite various uncertainties related to astronomical solutions this far back, climate sensitivity in a greenhouse world, and stratigraphic completeness. We seek to test published Paleocene astrochronologies by comparing the durations of magnetic polarity chrons as determined by cyclostratigraphy to their durations as determined by U/Pb geochronology. To complete this test, the Late Cretaceous to Paleocene Kiowa Core of the Denver Basin was analyzed. This core was chosen as it is from a terrestrial basin with high sediment accumulation rates, contains abundant layers of volcanic ash, and records a reliable magnetostratigraphy. Twenty-three paleomagnetic samples were collected from the core to improve the stratigraphic resolution of magnetic reversals that were coarsely constrained by earlier research. Once the depths of the geomagnetic reversals were precisely determined, ash layers that best constrained these reversals were selected for U/Pb geochronology. Durations of periods of normal and reverse magnetization were estimated based on these radiometrically dated ashes. Initial results indicate that the interval between the Chron C28n/C28r reversal and the K/T Boundary is ca 1.27 million years in duration. This is within error of previously published astrochronologically determined durations for the same time interval. Although additional independent comparisons are needed for a more complete test, our initial results indicate a remarkable consistency between these different geochronometers.

  17. Sensitivity Analysis of Core Neutronic Parameters in Electron Accelerator-driven Subcritical Advanced Liquid Metal Reactor

    Marziye Ebrahimkhani


    Full Text Available Calculation of the core neutronic parameters is one of the key components in all nuclear reactors. In this research, the energy spectrum and spatial distribution of the neutron flux in a uranium target have been calculated. In addition, sensitivity of the core neutronic parameters in accelerator-driven subcritical advanced liquid metal reactors, such as electron beam energy (Ee and source multiplication coefficient (ks, has been investigated. A Monte Carlo code (MCNPX_2.6 has been used to calculate neutronic parameters such as effective multiplication coefficient (keff, net neutron multiplication (M, neutron yield (Yn/e, energy constant gain (G0, energy gain (G, importance of neutron source (φ∗, axial and radial distributions of neutron flux, and power peaking factor (Pmax/Pave in two axial and radial directions of the reactor core for four fuel loading patterns. According to the results, safety margin and accelerator current (Ie have been decreased in the highest case of ks, but G and φ∗ have increased by 88.9% and 21.6%, respectively. In addition, for LP1 loading pattern, with increasing Ee from 100 MeV up to 1 GeV, Yn/e and G improved by 91.09% and 10.21%, and Ie and Pacc decreased by 91.05% and 10.57%, respectively. The results indicate that placement of the Np–Pu assemblies on the periphery allows for a consistent keff because the Np–Pu assemblies experience less burn-up.


    万里; 刘伟庆; 周叮; 方海


    The failure modes of sandwich beams with Balsa core are analyzed. The sandwich beams fail in several modes including the core shearing, the tensile/compressive failure of face sheet and the face sheet bulking.The tests demonstrate that the capacity of sandwich beams with Balsa core is greatly lower than that predicted theoretically and the failure modes are different from those of the common sandwich beams. The finite element analysis is performed considering the imperfection of the composite structure. Several FE models including the anisotropy and the initial imperfection are built up. The curve fittings of the numerical results are performed by means of the neutral network technique. The influence of the initial interfacial delaminations and the core cracks are investigated.%通过三点弯曲试验,分析了Balsa木芯材夹层梁的破坏模式.夹层梁发生了芯材剪切、面板拉伸/受压破坏、屈曲破坏.由测试结果发现,Balsa木火层梁的承载力远低于理论计算,且破坏模式也与一般情况有差别.采用有限元方法,考虑了夹层结构的初始缺陷和材料的各向异性,建立了一系列有限元分析模型,对夹层梁的承载失效问题进行了分析计算.计算结果采用神经网络算法进行拟合,分析了初始脱层和芯材缝隙裂纹对夹层梁承载能力的影响,为Balsa轻木夹层结构的制备、分析和设计提供参考.

  19. Analysis and Design of Double-sided Air core Linear Servo Motor with Trapezoidal Permanent Magnets

    Zhang, Yuqiu; Yang, Zilong; Yu, Minghu;


    In order to reduce the thrust ripple of linear servo system, a double-sided air core permanent magnet linear servo motor with trapezoidal shape permanent magnets (TDAPMLSM) is proposed in this paper. An analytical model of the motor for predicting the magnetic field in the air-gap at no......-load is introduced. This model is derived based on the equivalent magnetization intensity method, and its accuracy is validated by using the results obtained from the finite-element method. The key dimensions that affect the air-gap magnetic field are analyzed based on the analytical model, and the design...

  20. High-frequency paleoclimatic variability: a spectral analysis of the Vostok ice-core isotopic record

    Yiou, P.; Genthon, C.; Jouzel, J.; Le Treut, H.; Lorius, C.; Ghil, M.; Korotkevich, Y.S.


    This paper uses a recently analysed isotopic record from an ice core drilled at the Soviet Antartic Station VOSTOK, representing a total time span of about 160,000 years. Results obtained show the existence of a significative climatic variability at the time scale of 10,000 years and below. The many spectral peaks appear to be approximate linear combination of a little number among them, a clear indication of the non linear nature of climate fluctuations at these ''short'' time scales.

  1. Stability analysis of Hawaiian Island flanks using insight gained from strength testing of the HSDP core

    Thompson, Nick; Watters, Robert J.; Schiffman, Peter


    Hawaiian Island flank failures are recognized as the largest landslide events on Earth, reaching volumes of several thousand cubic kilometers and lengths of over 200 km and occurring on an average of once every 100 000 years. The 3.1 km deep Hawaii Scientific Drilling Project (HSDP) enabled an investigation of the rock mass strength variations on the island of Hawaii [Schiffman, P., Watters, R.J., Thompson, N., Walton, A.W., 2006. Hyaloclastites and the slope stability of Hawaiian volcanoes: insights from the Hawaiian Scientific Drilling Project's 3-km drill core. Journal of Volcanology and Geothermal Research, 151 (1-3): 217-228]. This study builds on that of Schiffman et al. [Schiffman, P., Watters, R.J., Thompson, N., Walton, A.W., 2006. Hyaloclastites and the slope stability of Hawaiian volcanoes: Insights from the Hawaiian Scientific Drilling Project's 3-km drill core. Journal of Volcanology and Geothermal Research, 151 (1-3): 217-228] by considering more in-depth rock mass classification and strength testing methods of the HSDP core. Geotechnical core logging techniques combined with laboratory strength testing methods show that rock strength differences exist within the edifice. Comparing the rock strength parameters obtained from the various volcano lithologies identified weak zones, suggesting the possible location of future slip surfaces for large flank failures. Relatively weak rock layers were recognized within poorly consolidated hyaloclastite zones, with increases in strength based on degree of alteration. Subaerial and submarine basalt flows are found to be significantly stronger. With the aid of digital elevation models, cross-sections have been developed of key flank areas on the island of Hawaii. Limit equilibrium slope stability analyses are performed on each cross-section using various failure criteria for the rock mass strength calculations. Based on the stability analyses the majority of the slopes analyzed are considered stable. In cases

  2. Numerical analysis of plastic hollow core microstructured fiber for Terahertz applications

    Vincetti, L.


    Propagation loss and dispersion characteristics of a hollow core microstructured fiber in the THz regime are numerically investigated. The fiber cladding consists of a triangular lattice formed by a periodic arrangement of dielectric tubes of Teflon. Numerical results show that guidance mechanism is the same of kagome and square lattice fibers. Low loss and low dispersion frequency ranges can be tuned just by changing the thickness of the tubes irrespectively of their diameter. Propagation loss four decades lower than the bulk absorption and dispersion lower 0.03 ps/nm km can be obtained over a band of about 1.7 THz centered at 2.1 THz.

  3. Validation of GAMMA+ model for Evaluating Heat Transfer of VHTR core in Accident Conditions by CFD analysis

    Shin, Dongho; Yoon, Sujong; Park, Gooncherl; Cho, Hyoungkyu [Seoul National Univ., Seoul (Korea, Republic of)


    KAERI has established a plan to demonstrate massive production of hydrogen using a VHTR by the early 2020s. In addition the GAMMA+ code is developed to analyze VHTR thermo-fluid transients at KAERI. One of the candidate reactor designs for VHTR is prismatic modular reactor (PMR), of which reference reactor is the 600MWth GT-MHR. This type of reactor has a passive safety system. During the High Pressure Conduction Cooling (HPCC) or Low Pressure Conduction Cooling (LPCC) accident, the core heats up by decay heat and then starts to cool down by conduction and radiation cooling to the Reactor Cavity Cooling System (RCCS) through the prismatic core. In this mechanism, the solid conduction occurs in graphite and fuel blocks, and the gas conduction and radiation occurs in coolant holes and bypass gaps. It is important to predict conduction and radiation heat transfer in the core for safety analysis. Effective thermal conductivity is derived by Maxwell's far-field methodology Radiation effect is expressed as corresponding conductivity and added to gas conductivity. In this study, ETC model used in GAMMA+ code is validated with the commercial CFD code, CFX-13. In this study, the effective thermal conductivity model of the GAMMA+ was evaluated by comparison of CFD analysis. The CFD analysis was conducted for various numbers and volume fractions of coolant holes and temperatures. Although slight disagreement was shown for the cases run with small number of holes, the result of GAMMA+ model is accurate for the large numbers of holes sufficiently. Since there are 102 coolant holes and 210 fuel holes in a fuel block, it is concluded that GAMMA+ model is proper formula for predicting effective thermal conductivity of the VHTR fuel block. However, in high temperature region above 500 .deg. C, the GAMMA+ model underestimates the effective thermal conductivity since radiation heat transfer is not reflected precisely. Further researches on it seem to be necessary.

  4. VERONA V6.22 – An enhanced reactor analysis tool applied for continuous core parameter monitoring at Paks NPP

    Végh, J., E-mail: [Institute for Energy and Transport of the Joint Research Centre of the European Commission, Postbus 2, NL-1755 ZG Petten (Netherlands); Pós, I., E-mail: [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Horváth, Cs., E-mail: [Centre for Energy Research, Hungarian Academy of Sciences, H-1525 Budapest 114, P.O. Box 49 (Hungary); Kálya, Z., E-mail: [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Parkó, T., E-mail: [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Ignits, M., E-mail: [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary)


    Between 2003 and 2007 the Hungarian Paks NPP performed a large modernization project to upgrade its VERONA core monitoring system. The modernization work resulted in a state-of-the-art system that was able to support the reactor thermal power increase to 108% by more accurate and more frequent core analysis. Details of the new system are given in Végh et al. (2008), the most important improvements were as follows: complete replacement of the hardware and the local area network; application of a new operating system and porting a large fraction of the original application software to the new environment; implementation of a new human-system interface; and last but not least, introduction of new reactor physics calculations. Basic novelty of the modernized core analysis was the introduction of an on-line core-follow module based on the standard Paks NPP core design code HELIOS/C-PORCA. New calculations also provided much finer spatial resolution, both in terms of axial node numbers and within the fuel assemblies. The new system was able to calculate the fuel applied during the first phase of power increase accurately, but it was not tailored to determine the effects of burnable absorbers as gadolinium. However, in the second phase of the power increase process the application of fuel assemblies containing three fuel rods with gadolinium content was intended (in order to optimize fuel economy), therefore off-line and on-line VERONA reactor physics models had to be further modified, to be able to handle the new fuel according to the accuracy requirements. In the present paper first a brief overview of the system version (V6.0) commissioned after the first modernization step is outlined; then details of the modified off-line and on-line reactor physics calculations are described. Validation results for new modules are treated extensively, in order to illustrate the extent and complexity of the V&V procedure associated with the development and licensing of the new

  5. [Legislation on primary care in Brazilian Unified National Health System: document analysis].

    Domingos, Carolina Milena; Nunes, Elisabete de Fátima Polo de Almeida; Carvalho, Brígida Gimenez; Mendonça, Fernanda de Freitas


    A reflection on Brazil's legislation for primary care helps understand the way health policy is implemented in the country. This study focuses on the legal provisions aimed at strengthening primary care, drawing on an analysis of documents from the Ministry of Health's priority actions, programs, and strategies. A total of 224 provisions were identified, in two groups of documents, so-called instituting provisions and complementary provisions. The former include the principles and guidelines of the Brazilian Unified National Health System (SUS) and also involve the expansion of actions. Financing was a quantitatively central theme, especially in the complementary provisions. The analysis led to reflection on the extent to which these strategies can induce linkage between health system managers and civil society in building a political project resulting in improvements and meeting the population's health needs.

  6. Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment

    Fernando Nalesso


    Full Text Available Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma. While the clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to assay for the presence of paternal DNA. Accordingly, in the present case, a patient with primary choriocarcinoma of the ovary with a non-gestational origin was confirmed by DNA analysis. The patient subsequently exhibited an excellent response to chemotherapy, and following surgery, achieved complete remission. A pathological analysis of surgical specimens further confirmed the absence of tumor.

  7. An Analysis of the Presentation of Art in the British Primary School Curriculum and Its Implications for Teaching

    Hallam, Jenny; Lee, Helen; Das Gupta, Mani


    This article presents an analysis of the way art is conceptualised in the British primary school curriculum and provides an historical framework that maps an evolution of ideas that have shaped the way art is presented in the modern day primary curriculum. In order to achieve this a Foucauldian style genealogical analysis is utilised to trace the…


    张英世; 张行


    On the basis about studying free bending for box beam with rectangular crosssection filled by honeycomb core, supplementary displacements and stresses of restrained bending for such beam were analyzed. The hypothesis for separated variables was adopted to solve displacement. According to this, three aspect equations of geometrical, physical and balance were obtained. With Galerkin's method, it is summed up as two-order ordinary differential equations with the attenuation character. Analysis makes clear that attenuation speed of stress is concerned with a big load or a small one, geometric dimensions of crosssection of beam, and physical parameter of material.

  9. Analysis of eddy currents in the two-half isolated vacuum vessel of an iron core tokamak

    Liu, L.J., E-mail: [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Rao, B.; Zhang, M.; Yu, K.X.; Zhuang, G. [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)


    Eddy currents in the vacuum vessel can cause many problems in plasma diagnostics and control, the fast analysis of eddy current is very important. In this paper, the characteristic of eddy currents in the thin shell of a two-half isolated vacuum vessel and the iron core's effect on eddy currents are analyzed, then an analytical method is used to calculate toroidal eddy currents in the vacuum vessel. Using this method, the eddy currents can be calculated rapidly which will benefit more accurate plasma reconstruction and real-time control. The calculated results by this method agree well with finite element method simulations based on J-TEXT configuration.

  10. Constitutive modeling and finite element procedure development for stress analysis of prismatic high temperature gas cooled reactor graphite core components

    Mohanty, Subhasish, E-mail: [Argonne National Laboratory, South Cass Avenue, Argonne, IL 60439 (United States); Majumdar, Saurindranath [Argonne National Laboratory, South Cass Avenue, Argonne, IL 60439 (United States); Srinivasan, Makuteswara [U.S. Nuclear Regulatory Commission, Washington, DC 20555 (United States)


    Highlights: • Finite element procedure developed for stress analysis of HTGR graphite component. • Realistic fluence profile and reflector brick shape considered for the simulation. • Also realistic H-451 grade material properties considered for simulation. • Typical outer reflector of a GT-MHR type reactor considered for numerical study. • Based on the simulation results replacement of graphite bricks can be scheduled. -- Abstract: High temperature gas cooled reactors, such as prismatic and pebble bed reactors, are increasingly becoming popular because of their inherent safety, high temperature process heat output, and high efficiency in nuclear power generation. In prismatic reactors, hexagonal graphite bricks are used as reflectors and fuel bricks. In the reactor environment, graphite bricks experience high temperature and neutron dose. This leads to dimensional changes (swelling and or shrinkage) of these bricks. Irradiation dimensional changes may affect the structural integrity of the individual bricks as well as of the overall core. The present paper presents a generic procedure for stress analysis of prismatic core graphite components using graphite reflector as an example. The procedure is demonstrated through commercially available ABAQUS finite element software using the option of user material subroutine (UMAT). This paper considers General Atomics Gas Turbine-Modular Helium Reactor (GT-MHR) as a bench mark design to perform the time integrated stress analysis of a typical reflector brick considering realistic geometry, flux distribution and realistic irradiation material properties of transversely isotropic H-451 grade graphite.

  11. Numerical analysis of crust formation in molten core-concrete interaction using MPS method

    Seiichi, Koshizuka; Shoji, Matsuura; Mizue, Sekine; Yoshiaki, Oka [Tokyo Univ., Tokai, Ibaraki (Japan). Nuclear Engineering Research Lab.; Hiroyuki, Obata [Japan Atomic Power Co., Tokyo (Japan)


    A two-dimensional code is developed for molten core-concrete interaction (MCCI) based on Moving Particle Semi-implicit (MPS) method. Heat transfer is calculated without any specific correlations. A particle can be changed to a moving (fluid) or fixed (solid) particle corresponding to its enthalpy, which provide the phase change model for particles. The phase change model is verified by one-dimensional test calculations. Nucleate boiling and radiation heat transfers are considered between the core debris and the water pool. The developed code is applied to SWISS-2 experiment in which stainless steel is used as the melt material. Calculated heat flux to the water pool agrees well with the experiment, though the ablation speed in the concrete is a little slower. A stable crust is formed in a short time after water is poured in and the heat flux to the water pool rapidly decreases. MACE-M0 using corium is also analyzed. The ablation speed of concrete is slower than that of SWISS-2 because of low heat conduction in corium. An unlimited geometry is analyzed by setting the cyclic boundary condition on the sides. When the crust is broken by the decomposition gas, heat transfer to the water pool is kept high for a longer time because the crust re-formation is delayed. (author)

  12. Structure analysis and core community detection of embodied resources networks among regional industries

    He, Xijun; Dong, Yanbo; Wu, Yuying; Wei, Guodan; Xing, Lizhi; Yan, Jia


    To address the double pressure of scarce resources and regional industrial isomorphism, this paper applied the concepts of exergy and embodied resources based on economic input-output (I-O) data. We constructed the embodied resources networks among the regional industries of Beijing-Tianjin-Hebei (also known as Jing-Jin-Ji) in China. We analyzed the rules of embodied resources consumption in the area's industries, identified the core community structures, and studied the characteristics of industrial homogeneity through regional comparisons. The results showed that the dependence on scarce resources of industrial operations in Beijing was less than in Jin-Ji, while the dependence on finance, technology, information, and other service resources in Beijing was higher than in Jin-Ji. The I-O efficiency of embodied resources among industries and the agglomeration of correlation relationships in industries with large embodied resources were higher than in Jin-Ji. The industrial coincidence degree in the ;bridge; industries and in the core community in Jin-Ji was higher than in Jing-Jin and Jing-Ji, which means the industrial homogeneous competition of Jin-Ji was higher, too. This study makes a significant contribution toward promoting the dislocation development of regional industries, accelerating the coordination of resources, and reducing homogeneity competition.

  13. Analysis and Design of Double-sided Air core Linear Servo Motor with Trapezoidal Permanent Magnets

    Zhang, Yuqiu; Yang, Zilong; Yu, Minghu


    In order to reduce the thrust ripple of linear servo system, a double-sided air core permanent magnet linear servo motor with trapezoidal shape permanent magnets (TDAPMLSM) is proposed in this paper. An analytical model of the motor for predicting the magnetic field in the air-gap at no-load is i......In order to reduce the thrust ripple of linear servo system, a double-sided air core permanent magnet linear servo motor with trapezoidal shape permanent magnets (TDAPMLSM) is proposed in this paper. An analytical model of the motor for predicting the magnetic field in the air-gap at no......-load is introduced. This model is derived based on the equivalent magnetization intensity method, and its accuracy is validated by using the results obtained from the finite-element method. The key dimensions that affect the air-gap magnetic field are analyzed based on the analytical model, and the design...... is optimized by using genetic algorithm. A thrust ripple reduction of 70.6% is achieved by optimization. The proposed analytical model may be used for a quick and reliable design and design optimization of the TDAPMLSM....

  14. CFD Analysis of a Hybrid Heat Pipe for In-Core Passive Decay Heat Removal System

    Jeong Yeong Shin; Kim, Kyung Mo; Bang, In Cheol [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)


    Station blackout (SBO) accident is the event that all AC power is totally lost from the failure of offsite and onsite power sources. Although electricity was provided from installed batteries for active system after shutdown, they were failed due to flooding after tsunami. The vulnerability of the current operating power plant's cooling ability during extended station blackout events is demonstrated and the importance of passive system becomes emphasized. Numerous researches about passive system have been studied for proper cooling residual heat after Fukushima nuclear power plant accident. Heat pipe is the effective passive heat transfer device that latent heat of vaporization is used to transport heat over long distance with even small temperature difference. Since liquid flows due to capillary force from wick structure and steam flows up due to buoyancy force, power is not necessary. Heat pipe is widely used in removal of local hot spot heat fluxes in CPU and thermal management in space crafts and satellites. Hybrid control rod, which consists of heat pipe with B{sub 4}C for wick structure material can be used for removing residual heat after. It can be applied to both for shutdown and cooling of decay heat in reactor. This concept is independent of external reactor situation like operator's mistake or malfunction of active cooling system. Heat pipe cooling system can be applied to Emergency Core Cooling System, In-Vessel Retention, containment and spent fuel cooling, contributing to decrease Core Damage Frequency.

  15. Analysis of Fusarium avenaceum Metabolites Produced during Wet Apple Core Rot

    Sørensen, Jens Laurids; Phipps, Richard Kerry; Nielsen, Kristian Fog


    Wet apple core rot (wACR) is a well-known disease of susceptible apple cultivars such as Gloster, Jona Gold, and Fuji. Investigations in apple orchards in Slovenia identified Fusarium avenaceum, a known producer of several mycotoxins, as the predominant causal agent of this disease. A LC-MS/MS me......Wet apple core rot (wACR) is a well-known disease of susceptible apple cultivars such as Gloster, Jona Gold, and Fuji. Investigations in apple orchards in Slovenia identified Fusarium avenaceum, a known producer of several mycotoxins, as the predominant causal agent of this disease. A LC......-MS/MS method was developed for the simultaneous detection of thirteen F. avenaceum metabolites including moniliformin, acuminatopyrone, chrysogine, chlamydosporol, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), aurofusarin, and enniatins A, A1, B, B1, B2, and B3 from artificially...... and naturally infected apples. Levels of moniliformin, antibiotic Y, aurofusarin, and enniatins A, A1, B, and B1 were quantitatively examined in artificially inoculated and naturally infected apples, whereas the remaining metabolites were qualitatively detected. Metabolite production was examined...

  16. Galactic cold cores. IV. Cold submillimetre sources: catalogue and statistical analysis

    Montillaud, J.; Juvela, M.; Rivera-Ingraham, A.; Malinen, J.; Pelkonen, V.-M.; Ristorcelli, I.; Montier, L.; Marshall, D. J.; Marton, G.; Pagani, L.; Toth, L. V.; Zahorecz, S.; Ysard, N.; McGehee, P.; Paladini, R.; Falgarone, E.; Bernard, J.-P.; Motte, F.; Zavagno, A.; Doi, Y.


    Context. For the project Galactic cold cores, Herschel photometric observations were carried out as a follow-up of cold regions of interstellar clouds previously identified with the Planck satellite. The aim of the project is to derive the physical properties of the population of cold sources and to study its connection to ongoing and future star formation. Aims: We build a catalogue of cold sources within the clouds in 116 fields observed with the Herschel PACS and SPIRE instruments. We wish to determine the general physical characteristics of the cold sources and to examine the correlations with their host cloud properties. Methods: From Herschel data, we computed colour temperature and column density maps of the fields. We estimated the distance to the target clouds and provide both uncertainties and reliability flags for the distances. The getsources multiwavelength source extraction algorithm was employed to build a catalogue of several thousand cold sources. Mid-infrared data were used, along with colour and position criteria, to separate starless and protostellar sources. We also propose another classification method based on submillimetre temperature profiles. We analysed the statistical distributions of the physical properties of the source samples. Results: We provide a catalogue of ~4000 cold sources within or near star forming clouds, most of which are located either in nearby molecular complexes (≲1 kpc) or in star forming regions of the nearby galactic arms (~2 kpc). About 70% of the sources have a size compatible with an individual core, and 35% of those sources are likely to be gravitationally bound. Significant statistical differences in physical properties are found between starless and protostellar sources, in column density versus dust temperature, mass versus size, and mass versus dust temperature diagrams. The core mass functions are very similar to those previously reported for other regions. On statistical grounds we find that

  17. Fracture toughness (K(IC) of a hot-pressed core ceramic based on fractographic analysis of fractured ceramic FPDs.

    Oh, Won-Suck; Park, Ju-Mi; Anusavice, Kenneth


    The objective of this study was to test the hypothesis that there is no significant difference between the fracture toughness (K(IC)) of an experimental hot-pressed core ceramic measured by fractographic analysis of failed ceramic prostheses and the values determined by other standard methods. Four groups were subjected to one of four test methods: group 1 = indentation strength technique (standard numerical calculation); group 2 = indentation strength technique (fractographic analysis); group 3 = flexure test of precracked specimens (fractographic analysis); and group 4 = fractographic analysis of failed three-unit fixed partial dentures (FPD). For groups 1 to 3, 20 ceramic bar specimens were subjected to three-point flexure at a cross-head speed of 0.5 mm/min until fracture occurred. For group 4, 10 failed FPDs were collected from a previous study. Stress values at failure were calculated from either a flexure stress equation (groups 1 to 3) or from finite element analyses (group 4). K(IC) values were calculated from an equation and fractographic measurement data. Mean fracture toughness ranged from 3.1 MPa x m1/2 (SD 0.2) (group 1) to 3.4 MPa x m1/2 (SD 0.2) (group 4). The mean K(IC) value for group 1 was significantly different from that of group 4; however, no significant differences were found between groups 1, 2, and 3, or between groups 2, 3, and 4. Fracture toughness for an experimental hot-pressed core ceramic measured by fractographic analysis in combination with finite element analysis was comparable with the values determined with other standard fractographic methods.

  18. Fluorescence in situ hybridization (FISH analysis of primary ocular adnexal MALT lymphoma

    Harada Mine


    Full Text Available Abstract Background It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. Methods We performed interphase fluorescence in situ hybridization (FISH analysis to detect translocations and aneuploidy in 34 cases of primary ocular adnexal MALT lymphoma, and reviewed the histopathological findings. Correlations between the results of FISH analysis, the histopathological features and the clinical data were also analyzed. Results Among the 34 cases, FISH analysis revealed t(14;18(q32;q21 in one case, trisomy 3 in 21 cases (62%, and trisomy 18 in 16 cases (47%. The cases with trisomy 18 had significantly more prominent lymphoepithelial lesions (LELs and less nodularity in the tumors. In regard to the clinical correlations, tumors with trisomy 18 were observed predominantly in females and younger patients; also, in the majority of the cases, the tumor was of conjunctival origin. All the cases with recurrence showed trisomy 18 in the tumor. Conclusion Primary ocular adnexal MALT lymphoma is a significantly heterogeneous entity. Cases with trisomy 18 may have unique clinicopathological features.

  19. Ice cores

    Svensson, Anders


    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  20. Ice cores

    Svensson, Anders


    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...