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Sample records for previously-ejected slow high-density

  1. Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation.

    Science.gov (United States)

    Plante, David T; Goldstein, Michael R; Cook, Jesse D; Smith, Richard; Riedner, Brady A; Rumble, Meredith E; Jelenchick, Lauren; Roth, Andrea; Tononi, Giulio; Benca, Ruth M; Peterson, Michael J

    2016-02-01

    Changes in slow waves during non-rapid eye movement (NREM) sleep in response to acute total sleep deprivation are well-established measures of sleep homeostasis. This investigation utilized high-density electroencephalography (hdEEG) to examine topographic changes in slow waves during repeated partial sleep deprivation. Twenty-four participants underwent a 6-day sleep restriction protocol. Spectral and period-amplitude analyses of sleep hdEEG data were used to examine changes in slow wave energy, count, amplitude, and slope relative to baseline. Changes in slow wave energy were dependent on the quantity of NREM sleep utilized for analysis, with widespread increases during sleep restriction and recovery when comparing data from the first portion of the sleep period, but restricted to recovery sleep if the entire sleep episode was considered. Period-amplitude analysis was less dependent on the quantity of NREM sleep utilized, and demonstrated topographic changes in the count, amplitude, and distribution of slow waves, with frontal increases in slow wave amplitude, numbers of high-amplitude waves, and amplitude/slopes of low amplitude waves resulting from partial sleep deprivation. Topographic changes in slow waves occur across the course of partial sleep restriction and recovery. These results demonstrate a homeostatic response to partial sleep loss in humans. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  2. Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation

    Directory of Open Access Journals (Sweden)

    Plante David T

    2012-09-01

    Full Text Available Abstract Background Sleep disturbance plays an important role in major depressive disorder (MDD. Prior investigations have demonstrated that slow wave activity (SWA during sleep is altered in MDD; however, results have not been consistent across studies, which may be due in part to sex-related differences in SWA and/or limited spatial resolution of spectral analyses. This study sought to characterize SWA in MDD utilizing high-density electroencephalography (hdEEG to examine the topography of SWA across the cortex in MDD, as well as sex-related variation in SWA topography in the disorder. Methods All-night recordings with 256 channel hdEEG were collected in 30 unipolar MDD subjects (19 women and 30 age and sex-matched control subjects. Spectral analyses of SWA were performed to determine group differences. SWA was compared between MDD and controls, including analyses stratified by sex, using statistical non-parametric mapping to correct for multiple comparisons of topographic data. Results As a group, MDD subjects demonstrated significant increases in all-night SWA primarily in bilateral prefrontal channels. When stratified by sex, MDD women demonstrated global increases in SWA relative to age-matched controls that were most consistent in bilateral prefrontal regions; however, MDD men showed no significant differences relative to age-matched controls. Further analyses demonstrated increased SWA in MDD women was most prominent in the first portion of the night. Conclusions Women, but not men with MDD demonstrate significant increases in SWA in multiple cortical areas relative to control subjects. Further research is warranted to investigate the role of SWA in MDD, and to clarify how increased SWA in women with MDD is related to the pathophysiology of the disorder.

  3. Experimental study of the crack depth ratio threshold to analyze the slow crack growth by creep of high density polyethylene pipes

    International Nuclear Information System (INIS)

    Laiarinandrasana, Lucien; Devilliers, Clémence; Lucatelli, Jean Marc; Gaudichet-Maurin, Emmanuelle; Brossard, Jean Michel

    2014-01-01

    To assess the durability of drinking water connection pipes subjected to oxidation and slow crack growth, a comprehensive database was constructed on a novel specimen geometry: the pre-cracked NOL ring. 135 tests were carried out consisting of initial crack depth ratio ranging from 0.08 to 0.6; single or double longitudinal cracks: tensile with steady strain rate and creep loading. A threshold value of the crack depth ratio of 0.2, induced by the oxidation was determined by analyzing several mechanical parameters. This threshold value was shown to be independent on the strain rate effects, single or double crack configuration and the kind of loading: tensile or creep. Creep test results with crack depth ratio larger than 0.2 were then utilized to establish a failure assessment diagram. A methodology allowing the prediction of residual lifetime of in-service pipes was proposed, using this diagram. - Highlights: • Experimental data on pre-cracked rings featuring a longitudinally cracked HDPE pipe. • Crack depth ratio threshold for slow crack growth study consecutive to oxidation. • Investigation of the effects of the single/double notch(es) and of the strain rate. • Original results obtained from tests performed with tensile and creep loadings. • Correlation between creep initiation time and C* with DENT and ring specimens

  4. High Density Matter

    Directory of Open Access Journals (Sweden)

    Stone J.R.

    2013-12-01

    Full Text Available The microscopic composition and properties of matter at super-saturation densities have been the subject of intense investigation for decades. The scarcity of experimental and observational data has led to the necessary reliance on theoretical models. There remains great uncertainty in these models which, of necessity, have to go beyond the over-simple assumption that high density matter consists only of nucleons and leptons. Heavy strange baryons, mesons and quark matter in different forms and phases have to be included to fulfil basic requirements of fundamental laws of physics. In this contribution latest developments in construction of the Equation of State (EoS of high-density matter at zero and finite temperature assuming different composition of matter will be discussed. Critical comparison of model EoS with available experimental data from heavy ion collisions and observations on neutron stars, including gravitational mass, radii and cooling patterns and data on X-ray burst sources and low mass X-ray binaries are made. Fundamental differences between the EoS of low-density, high temperature matter, such as is created in heavy ion collisions and of high-density, low temperature compact objects is discussed.

  5. High-density multicore fibers

    DEFF Research Database (Denmark)

    Takenaga, K.; Matsuo, S.; Saitoh, K.

    2016-01-01

    High-density single-mode multicore fibers were designed and fabricated. A heterogeneous 30-core fiber realized a low crosstalk of −55 dB. A quasi-single-mode homogeneous 31-core fiber attained the highest core count as a single-mode multicore fiber.......High-density single-mode multicore fibers were designed and fabricated. A heterogeneous 30-core fiber realized a low crosstalk of −55 dB. A quasi-single-mode homogeneous 31-core fiber attained the highest core count as a single-mode multicore fiber....

  6. High Density Fuel Development for Research Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Daniel Wachs; Dennis Keiser; Mitchell Meyer; Douglas Burkes; Curtis Clark; Glenn Moore; Jan-Fong Jue; Totju Totev; Gerard Hofman; Tom Wiencek; Yeon So Kim; Jim Snelgrove

    2007-09-01

    An international effort to develop, qualify, and license high and very high density fuels has been underway for several years within the framework of multi-national RERTR programs. The current development status is the result of significant contributions from many laboratories, specifically CNEA in Argentina, AECL in Canada, CEA in France, TUM in Germany, KAERI in Korea, VNIIM, RDIPE, IPPE, NCCP and RIARR in Russia, INL, ANL and Y-12 in USA. These programs are mainly engaged with UMo dispersion fuels with densities from 6 to 8 gU/cm3 (high density fuel) and UMo monolithic fuel with density as high as 16 gU/cm3 (very high density fuel). This paper, mainly focused on the French & US programs, gives the status of high density UMo fuel development and perspectives on their qualification.

  7. Neutron shielding properties of a borated high-density glass

    Directory of Open Access Journals (Sweden)

    Saeed Aly Abdallah

    2017-01-01

    Full Text Available The neutron shielding properties of a borated high density glass system was characterized experimentally. The total removal macroscopic cross-section of fast neutrons, slow neutrons as well as the linear attenuation coefficient of total gamma rays, primary in addition to secondary, were measured experimentally under good geometric condition to characterize the attenuation properties of (75-x B2O3-1Li2O-5MgO-5ZnO-14Na2O-xBaO glassy system. Slabs of different thicknesses from the investigated glass system were exposed to a collimated beam of neutrons emitted from 252Cf and 241Am-Be neutron sources in order to measure the attenuation properties of fast and slow neutrons as well as total gamma rays. Results confirmed that barium borate glass was suitable for practical use in the field of radiation shielding.

  8. Magnetization of High Density Hadronic Fluid

    DEFF Research Database (Denmark)

    Bohr, Henrik; Providencia, Constanca; da Providencia, João

    2012-01-01

    In the present paper the magnetization of a high density relativistic fluid of elementary particles is studied. At very high densities, such as may be found in the interior of a neutron star, when the external magnetic field is gradually increased, the energy of the normal phase of the fluid...... in the particle fluid. For nuclear densities above 2 to 3 rho(0), where rho(0) is the equilibrium nuclear density, the resulting magnetic field turns out to be rather huge, of the order of 10(17) Gauss....

  9. Supernovae and high density nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Kahana, S.

    1986-01-01

    The role of the nuclear equation of state (EOS) in producing prompt supernova explosions is examined. Results of calculations of Baron, Cooperstein, and Kahana incorporating general relativity and a new high density EOS are presented, and the relevance of these calculations to laboratory experiments with heavy ions considered. 31 refs., 6 figs., 2 tabs.

  10. Proteomic analysis of high-density lipoprotein

    NARCIS (Netherlands)

    Rezaee, Farhad; Casetta, Bruno; Levels, J. Han M.; Speijer, Dave; Meijers, Joost C. M.

    2006-01-01

    Plasma lipoproteins, such as high-density lipoprotein (HDL), can serve as carriers for a wide range of proteins that are involved in processes such as lipid metabolism, thrombosis, inflammation and atherosclerosis. The identification of HDL-associated proteins is essential with regards to

  11. High Density Jet Fuel Supply and Specifications

    Science.gov (United States)

    1986-01-01

    6 ) (i ) ( 8 ) (91 ( coal tar , tar sands extract, shale oil) to jet fuels, although not necessarily high density fuels. All the above work has...Jet Fuel Analysis Workshop, Golden, Colorado, November 14, 1985. 2. A. Korosi, J. N. Rubin, Stone and Webster Engineering Corp, " Hydroprocessing of...Moore, Ashland Petroleum Co., "Jet Fuel Production from Tar Sands and Heavy Oil," by ART/Reduced Crude Conversion Process’, March 26, 1985. 8. A. F

  12. Some recent efforts toward high density implosions

    International Nuclear Information System (INIS)

    McClellan, G.E.

    1980-01-01

    Some recent Livermore efforts towards achieving high-density implosions are presented. The implosion dynamics necessary to compress DT fuel to 10 to 100 times liquid density are discussed. Methods of diagnosing the maximum DT density for a specific design are presented along with results to date. The dynamics of the double-shelled target with an exploding outer shell are described, and some preliminary experimental results are presented

  13. High density, low open porosity magnesia ceramics

    International Nuclear Information System (INIS)

    Alecu, I.D.; Stead, R.J.

    1998-01-01

    Many modern high-tech applications require magnesia ceramic components with high bulk densities and very low apparent porosities. Quite commonly, bulk densities above 3500 kg.m -3 and open porosities close to zero are specified for such applications of magnesia ceramics. The paper presents the recent achievements of Rojan Advanced Ceramics in the field of high density, very low open porosity magnesia ceramic materials and special products, including labware and planar components. Copyright (1998) Australasian Ceramic Society

  14. Spin polarization in high density quark matter

    DEFF Research Database (Denmark)

    Bohr, Henrik; Panda, Prafulla K.; Providênci, Constanca

    2013-01-01

    We investigate the occurrence of a ferromagnetic phase transition in high density hadronic matter (e.g., in the interior of a neutron star). This could be induced by a four-fermion interaction analogous to the one which is responsible for chiral symmetry breaking in the Nambu-Jona-Lasinio model...... the so-called 2 flavor super-conducting phase to the ferromagnetic phase arises. The color-flavor-locked phase may be completely hidden by the FP....

  15. Complete reduction of high-density UO2 to metallic U in molten Li2O-LiCl

    Science.gov (United States)

    Choi, Eun-Young; Lee, Jeong

    2017-10-01

    The large size and high density of spent fuel pellets make it difficult to use the pellets directly in electrolytic reduction (also called as oxide reduction, OR) for pyroprocessing owing to the slow diffusion of molten Li2O-LiCl salt electrolyte into the pellets. In this study, we investigated complete OR of high-density UO2 to metallic U without any remaining UO2. Only partial reductions near the surface of high-density UO2 pellets were observed under operation conditions employing fast electrolysis rate that allowed previously complete reduction of low-density UO2 pellets. Complete reduction of high-density UO2 pellets was observed at fast electrolysis rate when the pellet size was reduced. The complete reduction of high-density UO2 pellets without size reduction was achieved at slow electrolysis rate, which allowed sufficient chemical reduction of UO2 with the lithium metal generated by the cathode reaction.

  16. High density nonmagnetic cobalt in thin films

    OpenAIRE

    Banu, Nasrin; Singh, Surendra; Basu, Saibal; Roy, Anupam; Movva, Hema C. P.; Dev, B. N.

    2017-01-01

    Recently high density (HD) nonmagnetic (NM) cobalt has been discovered in a cobalt thin film, grown on Si(111). This cobalt film had a natural cobalt oxide at the top. The oxide layer forms when the film is taken out of the electron-beam deposition chamber and exposed to air. Thin HD NM cobalt layers were found near the cobalt/silicon and the cobalt-oxide/cobalt interfaces, while the thicker mid-depth region of the film was hcp cobalt with normal density and normal magnetic moment. If an ultr...

  17. High density data recording for SSCL linac

    International Nuclear Information System (INIS)

    VanDeusen, A.L.; Crist, C.

    1993-01-01

    The Superconducting Super Collider Laboratory and AlliedSignal Aerospace have collaboratively developed a high density data monitoring system for beam diagnostic activities. The 128 channel data system is based on a custom multi-channel high speed digitizer card for the VXI bus. The card is referred to as a Modular Input VXI (MIX) digitizer. Multiple MIX cards are used in the complete system to achieve the necessary high channel density requirements. Each MIX digitizer card also contains programmable signal conditioning, and enough local memory to complete an entire beam scan without assistance from the host processor

  18. High density, low open porosity magnesia ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Alecu, I.D.; Stead, R.J. [Rojan Advanced Ceramics Pty Ltd, Osborne Park, WA (Australia)

    1998-12-31

    Many modern high-tech applications require magnesia ceramic components with high bulk densities and very low apparent porosities. Quite commonly, bulk densities above 3500 kg.m{sup -3} and open porosities close to zero are specified for such applications of magnesia ceramics. The paper presents the recent achievements of Rojan Advanced Ceramics in the field of high density, very low open porosity magnesia ceramic materials and special products, including labware and planar components. Copyright (1998) Australasian Ceramic Society 4 refs., 2 tabs., 1 fig.

  19. Models for Experimental High Density Housing

    Science.gov (United States)

    Bradecki, Tomasz; Swoboda, Julia; Nowak, Katarzyna; Dziechciarz, Klaudia

    2017-10-01

    The article presents the effects of research on models of high density housing. The authors present urban projects for experimental high density housing estates. The design was based on research performed on 38 examples of similar housing in Poland that have been built after 2003. Some of the case studies show extreme density and that inspired the researchers to test individual virtual solutions that would answer the question: How far can we push the limits? The experimental housing projects show strengths and weaknesses of design driven only by such indexes as FAR (floor attenuation ratio - housing density) and DPH (dwellings per hectare). Although such projects are implemented, the authors believe that there are reasons for limits since high index values may be in contradiction to the optimum character of housing environment. Virtual models on virtual plots presented by the authors were oriented toward maximising the DPH index and DAI (dwellings area index) which is very often the main driver for developers. The authors also raise the question of sustainability of such solutions. The research was carried out in the URBAN model research group (Gliwice, Poland) that consists of academic researchers and architecture students. The models reflect architectural and urban regulations that are valid in Poland. Conclusions might be helpful for urban planners, urban designers, developers, architects and architecture students.

  20. Current drive in high density tokamak plasma

    International Nuclear Information System (INIS)

    Sakaguchi, Seiichiro; Jotaki, Eriko; Kawasaki, Shoji; Moriyama, Shin-ichi; Nagao, Akihiro; Nakamura, Kazuo; Nakamura, Yukio; Hiraki, Naoki; Itoh, Satoshi

    1989-01-01

    Current drive in high density tokamak plasma is investigated, with special attention given to mode conversion and proximity conditions that characterize the propagation of electromagnetic waves in the case of current drive by lower hybrid waves. A simple model is used to evaluate the current drive efficiency, and its dependence on various parameters associated with equipment is investigated to provide information required in designing experimental equipment. A strong troidal magnetic field is necessary to produce high density plasma, and incident electromagnetic waves should have a high frequency to prevent the mode conversion, suggesting that a high frequency and a strong troidal field are essential to permit desirable propagation of incident electromagnetic waves. The evaluation of the current drive efficiency shows that the proximity conditions and the power spectrum of the lower hybrid waves entering the plasma are of importance. The average refraction factor in the direction of the troidal field should be larger than but close to that determined from the proximity conditions in order to increase the drive efficiency. As the intensity of the troidal field increases, the refraction factor determined from the proximity conditions decreases, leading to an increase in the drive efficiency. (N.K.)

  1. Cortical high-density counterstream architectures.

    Science.gov (United States)

    Markov, Nikola T; Ercsey-Ravasz, Mária; Van Essen, David C; Knoblauch, Kenneth; Toroczkai, Zoltán; Kennedy, Henry

    2013-11-01

    Small-world networks provide an appealing description of cortical architecture owing to their capacity for integration and segregation combined with an economy of connectivity. Previous reports of low-density interareal graphs and apparent small-world properties are challenged by data that reveal high-density cortical graphs in which economy of connections is achieved by weight heterogeneity and distance-weight correlations. These properties define a model that predicts many binary and weighted features of the cortical network including a core-periphery, a typical feature of self-organizing information processing systems. Feedback and feedforward pathways between areas exhibit a dual counterstream organization, and their integration into local circuits constrains cortical computation. Here, we propose a bow-tie representation of interareal architecture derived from the hierarchical laminar weights of pathways between the high-efficiency dense core and periphery.

  2. Drum vortons in high density QCD

    International Nuclear Information System (INIS)

    Buckley, Kirk B. W.; Metlitski, Max A.; Zhitnitsky, Ariel R.

    2003-01-01

    Recently it was shown that high density QCD supports of number of topological defects. In particular, there are U(1) Y strings that arise due to K 0 condensation that occurs when the strange quark mass is relatively large. The unique feature of these strings is that they possess a nonzero K + condensate that is trapped on the core. In the following we will show that these strings (with nontrivial core structure) can form closed loops with conserved charge and currents trapped on the string world sheet. The presence of conserved charges allows these topological defects, called vortons, to carry angular momentum, which makes them classically stable objects. We also give arguments demonstrating that vortons carry angular momentum very efficiently (in terms of energy per unit angular momentum) such that they might be the important degrees of freedom in the cores of neutron stars

  3. Nanotechnology for Synthetic High Density Lipoproteins

    Science.gov (United States)

    Luthi, Andrea J.; Patel, Pinal C.; Ko, Caroline H.; Mutharasan, R. Kannan; Mirkin, Chad A.; Thaxton, C. Shad

    2014-01-01

    Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat atherosclerosis is to increase the amount of circulating high density lipoproteins (HDL), which transport cholesterol from peripheral tissues to the liver for excretion. The process, known as reverse cholesterol transport, is thought to be one of the main reasons for the significant inverse correlation observed between HDL blood levels and the development of CHD. This article highlights the most common strategies for treating atherosclerosis using HDL. We further detail potential treatment opportunities that utilize nanotechnology to increase the amount of HDL in circulation. The synthesis of biomimetic HDL nanostructures that replicate the chemical and physical properties of natural HDL provides novel materials for investigating the structure-function relationships of HDL and for potential new therapeutics to combat CHD. PMID:21087901

  4. High Density Lipoprotein and it's Dysfunction.

    Science.gov (United States)

    Eren, Esin; Yilmaz, Necat; Aydin, Ozgur

    2012-01-01

    Plasma high-density lipoprotein cholesterol(HDL-C) levels do not predict functionality and composition of high-density lipoprotein(HDL). Traditionally, keeping levels of low-density lipoprotein cholesterol(LDL-C) down and HDL-C up have been the goal of patients to prevent atherosclerosis that can lead to coronary vascular disease(CVD). People think about the HDL present in their cholesterol test, but not about its functional capability. Up to 65% of cardiovascular death cannot be prevented by putative LDL-C lowering agents. It well explains the strong interest in HDL increasing strategies. However, recent studies have questioned the good in using drugs to increase level of HDL. While raising HDL is a theoretically attractive target, the optimal approach remains uncertain. The attention has turned to the quality, rather than the quantity, of HDL-C. An alternative to elevations in HDL involves strategies to enhance HDL functionality. The situation poses an opportunity for clinical chemists to take the lead in the development and validation of such biomarkers. The best known function of HDL is the capacity to promote cellular cholesterol efflux from peripheral cells and deliver cholesterol to the liver for excretion, thereby playing a key role in reverse cholesterol transport (RCT). The functions of HDL that have recently attracted attention include anti-inflammatory and anti-oxidant activities. High antioxidant and anti-inflammatory activities of HDL are associated with protection from CVD.This review addresses the current state of knowledge regarding assays of HDL functions and their relationship to CVD. HDL as a therapeutic target is the new frontier with huge potential for positive public health implications.

  5. High-density hybrid interconnect methodologies

    International Nuclear Information System (INIS)

    John, J.; Zimmermann, L.; Moor, P.De; Hoof, C.Van

    2003-01-01

    Full text: The presentation gives an overview of the state-of-the-art of hybrid integration and in particular the IMEC technological approaches that will be able to address future hybrid detector needs. The dense hybrid flip-chip integration of an array of detectors and its dedicated readout electronics can be achieved with a variety of solderbump techniques such as pure Indium or Indium alloys, Ph-In, Ni/PbSn, but also conducting polymers... Particularly for cooled applications or ultra-high density applications, Indium solderbump technology (electroplated or evaporated) is the method of choice. The state-of-the-art of solderbump technologies that are to a high degree independent of the underlying detector material will be presented and examples of interconnect densities between 5x1E4cm-2 and 1x1E6 cm-2 will be demonstrated. For several classes of detectors, flip-chip integration is not allowed since the detectors have to be illuminated from the top. This applies to image sensors for EUV applications such as GaN/AlGaN based detectors and to MEMS-based sensors. In such cases, the only viable interconnection method has to be through the (thinned) detector wafer followed by a solderbump-based integration. The approaches for dense and ultra-dense through-the-wafer interconnect 'vias' will be presented and wafer thinning approaches will be shown

  6. HIGH DENSITY QCD WITH HEAVY-IONS

    CERN Multimedia

    The Addendum 1 to Volume 2 of the CMS Physics TDR has been published The Heavy-Ion analysis group completed the writing of a TDR summarizing the CMS plans in using heavy ion collisions to study high density QCD. The document was submitted to the LHCC in March and presented in the Open Session of the LHCC on May 9th. The study of heavy-ion physics at the LHC is promising to be very exciting. LHC will open a new energy frontier in ultra-relativistic heavy-ion physics. The collision energy of heavy nuclei at sNN = 5.5 TeV will be thirty times larger than what is presently available at RHIC. We will certainly probe quark and gluon matter at unprecedented values of energy density. The prime goal of this research programme is to study the fundamental theory of the strong interaction - Quantum Chromodynamics (QCD) - in extreme conditions of temperature, density and parton momentum fraction (low-x). Such studies, with impressive experimental and theoretical advances in recent years thanks to the wealth of high-qua...

  7. Thyrotropin interaction with high-density lipoproteins.

    Science.gov (United States)

    Bifulco, M; Saroff, H A; Kohn, L D; Aloj, S M

    1985-07-09

    Human high-density lipoproteins (HDL), but not other lipoprotein classes, bind bovine thyrotropin (TSH) with moderately high affinity. Binding of 125I-labeled HDL to TSH has been measured in a solid-phase assay; it is saturable and can be displaced by unlabeled HDL but not by other lipoproteins or bovine serum albumin. The interaction of HDL with TSH has been studied by fluorescence spectroscopy: HDL specifically modifies the fluorescence properties of the biologically active dansyl derivative (DNS, (5-dimethyl-aminonaphtalene-1-sulfonyl) chloride) of TSH (DNS-TSH) causing a 12 nm shift to lower wavelength of the emission maximum, a two-fold increase of the quantum yield and a significant increase of fluorescence polarization. The primary site of TSH binding on the HDL particle is likely to be located on its protein moieties, since other lipoprotein classes, which share similar lipids with HDL, do not bind TSH. 125I-labeled apolipoprotein A-I binds TSH in the solid-phase assay and titration of DNS-TSH with apolipoprotein A-I causes perturbations nearly identical to those observed with intact HDL. One HDL particle has at least 12 binding sites for TSH with an association constant, K = 10(7) M-1 whereas one apolipoprotein A-I molecule binds one or two TSH molecules with an association constant slightly lower than that for HDL (K = 10(6) M-1). The lipid moieties of HDL also appears to be perturbed by the interaction with TSH.

  8. High-density lipoprotein cholesterol: How High

    Directory of Open Access Journals (Sweden)

    G Rajagopal

    2012-01-01

    Full Text Available The high-density lipoprotein cholesterol (HDL-C is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors.

  9. Regulation of high-density lipoprotein metabolism.

    Science.gov (United States)

    Rye, Kerry-Anne; Barter, Philip J

    2014-01-03

    There is compelling evidence from human population studies that plasma levels of high-density lipoprotein (HDL) cholesterol correlate inversely with cardiovascular risk. Identification of this relationship has stimulated research designed to understand how HDL metabolism is regulated. The ultimate goal of these studies has been to develop HDL-raising therapies that have the potential to decrease the morbidity and mortality associated with atherosclerotic cardiovascular disease. However, the situation has turned out to be much more complex than originally envisaged. This is partly because the HDL fraction consists of multiple subpopulations of particles that vary in terms of shape, size, composition, and surface charge, as well as in their potential cardioprotective properties. This heterogeneity is a consequence of the continual remodeling and interconversion of HDL subpopulations by multiple plasma factors. Evidence that the remodeling of HDLs may impact on their cardioprotective properties is beginning to emerge. This serves to highlight the importance of understanding not only how the remodeling and interconversion of HDL subpopulations is regulated but also how these processes are affected by agents that increase HDL levels. This review provides an overview of what is currently understood about HDL metabolism and how the subpopulation distribution of these lipoproteins is regulated.

  10. Laser Direct Routing for High Density Interconnects

    Science.gov (United States)

    Moreno, Wilfrido Alejandro

    Diffused Link. A high density Laser Vertical Link with resistance values below 10 ohms was developed, studied and tested using design of experiment methodologies. The vertical link offers excellent advantages in the area of quick prototyping of electronic circuits, but even more important, due to having similar characteristics to a foundry produced via, it gives quick transfer from the prototype system verification stage to the mass production stage.

  11. Analysis of surface degradation of high density polyethylene (HDPE ...

    Indian Academy of Sciences (India)

    Unknown

    Analysis of surface degradation of high density polyethylene (HDPE) insulation ... ammonium chloride as the contaminant, in high density polyethylene ..... liquid in the material. When diffusion is driven by the concentration gradient and if there is no chemical change between liquid and material, this would result in mass.

  12. Two distinct synchronization processes in the transition to sleep: a high-density electroencephalographic study.

    Science.gov (United States)

    Siclari, Francesca; Bernardi, Giulio; Riedner, Brady A; LaRocque, Joshua J; Benca, Ruth M; Tononi, Giulio

    2014-10-01

    To assess how the characteristics of slow waves and spindles change in the falling-asleep process. Participants undergoing overnight high-density electroencephalographic recordings were awakened at 15- to 30-min intervals. One hundred forty-one falling-asleep periods were analyzed at the scalp and source level. Sleep laboratory. Six healthy participants. Serial awakenings. The number and amplitude of slow waves followed two dissociated, intersecting courses during the transition to sleep: slow wave number increased slowly at the beginning and rapidly at the end of the falling-asleep period, whereas amplitude at first increased rapidly and then decreased linearly. Most slow waves occurring early in the transition to sleep had a large amplitude, a steep slope, involved broad regions of the cortex, predominated over frontomedial regions, and preferentially originated from the sensorimotor and the posteromedial parietal cortex. Most slow waves occurring later had a smaller amplitude and slope, involved more circumscribed parts of the cortex, and had more evenly distributed origins. Spindles were initially sparse, fast, and involved few cortical regions, then became more numerous and slower, and involved more areas. Our results provide evidence for two types of slow waves, which follow dissociated temporal courses in the transition to sleep and have distinct cortical origins and distributions. We hypothesize that these two types of slow waves result from two distinct synchronization processes: (1) a "bottom-up," subcorticocortical, arousal system-dependent process that predominates in the early phase and leads to type I slow waves, and (2) a "horizontal," corticocortical synchronization process that predominates in the late phase and leads to type II slow waves. The dissociation between these two synchronization processes in time and space suggests that they may be differentially affected by experimental manipulations and sleep disorders. © 2014 Associated Professional

  13. Usefulness of dynamic subtraction CT for intracranial high density lesions

    Energy Technology Data Exchange (ETDEWEB)

    Takagi, Ryo; Hayashi, Hiromitsu; Ichikawa, Taro; Kumazaki, Tatsuo (Nippon Medical School, Tokyo (Japan))

    1994-04-01

    Dynamic subtraction CT (DSCT) using a high speed Rotate/Rotate CT Scanner (Toshiba Xforce) was performed on 10 patients with intracranial high density lesions such as brain tumors and vascular malformations. In comparison with conventional contrast enhanced CT, the technique of dynamic subtraction CT enabled us to evaluate more clearly the contrast enhancement of high density lesions and to separate more easily the lesions from hematoma and calcification, which are shown as avascular areas. The results suggest that DSCT is a valuable method for evaluating the contrast enhancement of intracranial high density lesions. (author).

  14. Observable to explore high density behaviour of symmetry energy

    OpenAIRE

    Sood, Aman D.

    2011-01-01

    We aim to see the sensitivity of collective transverse in-plane flow to symmetry energy at low as well as high densities and also to see the effect of different density dependencies of symmetry energy on the same.

  15. High regression rate, high density hybrid fuels, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR program will investigate high energy density novel nanofuels combined with high density binders for use with an N2O oxidizer. Terves has developed...

  16. 128x128 Ultra-High Density Optical Interconnect Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Future NASA programs like Tertiary Planet Finder (TPF) require high density deformable mirrors with upto 16,000 actuators to enable direct imaging of planets around...

  17. Wake high-density electroencephalographic spatiospectral signatures of Insomnia

    NARCIS (Netherlands)

    Colombo, Michele A.; Ramautar, Jennifer R.; Wei, Yishul; Gomez-Herrero, Germán; Stoffers, Diederick; Wassing, Rick; Benjamins, Jeroen S.; Tagliazucchi, Enzo; van der Werf, Ysbrand; Cajochen, Christian; Van Someren, Eus J.W.

    2016-01-01

    Study Objectives: Although daytime complaints are a defining characteristic of insomnia, most EEG studies evaluated sleep only. We used high-density electroencephalography to investigate wake resting state oscillations characteristic of insomnia disorder (ID) at a fine-grained spatiospectral

  18. The high density effects in the Drell-Yan process

    International Nuclear Information System (INIS)

    Betemps, M.A.; Gay Ducati, M.B.; Ayala Filho, A.L.

    2003-01-01

    The high density effects in the Drell-Yan process (q q-bar → γ * →l + l - ) are investigated for pA collisions at RHIC and LHC energies. In particular, we use a set of nuclear parton distributions that describes the present nuclear eA and pA data in the DGLAP approach including the high density effects introduced in the perturbative Glauber-Mueller approach. (author)

  19. Copy Number Variation Detection via High-Density SNP Genotyping

    OpenAIRE

    sprotocols

    2014-01-01

    Authors: Kai Wang & Maja Bucan ### INTRODUCTION High-density single nucleotide polymorphism (SNP) genotyping arrays recently have been used for copy number variation (CNV) detection and analysis, because the arrays can serve a dual role for SNP- and CNV-based association studies. They also can provide considerably higher precision and resolution than traditional techniques. Here we describe PennCNV, a computational protocol designed for CNV detection from high-density SNP genotyping d...

  20. High-density-plasma diagnostics in magnetic-confinement fusion

    International Nuclear Information System (INIS)

    Jahoda, F.C.

    1982-01-01

    The lectures will begin by defining high density in the context of magnetic confinement fusion research and listing some alternative reactor concepts, ranging from n/sub e/ approx. 2 x 10 14 cm -3 to several orders of magnitude greater, that offer potential advantages over the main-line, n/sub e/ approx. 1 x 10 14 cm -3 , Tokamak reactor designs. The high density scalings of several major diagnostic techniques, some favorable and some disadvantageous, will be discussed. Special emphasis will be given to interferometric methods, both electronic and photographic, for which integral n/sub e/dl measurements and associated techniques are accessible with low wavelength lasers. Reactor relevant experience from higher density, smaller dimension devices exists. High density implies high β, which implies economies of scale. The specialized features of high β diagnostics will be discussed

  1. High-density scintillating glasses for a proton imaging detector

    Science.gov (United States)

    Tillman, I. J.; Dettmann, M. A.; Herrig, V.; Thune, Z. L.; Zieser, A. J.; Michalek, S. F.; Been, M. O.; Martinez-Szewczyk, M. M.; Koster, H. J.; Wilkinson, C. J.; Kielty, M. W.; Jacobsohn, L. G.; Akgun, U.

    2017-06-01

    High-density scintillating glasses are proposed for a novel proton-imaging device that can improve the accuracy of the hadron therapy. High-density scintillating glasses are needed to build a cost effective, compact calorimeter that can be attached to a gantry. This report summarizes the study on Europium, Terbium, and Cerium-doped scintillating glasses that were developed containing heavy elements such as Lanthanum, Gadolinium, and Tungsten. The density of the samples reach up to 5.9 g/cm3, and their 300-600 nm emission overlaps perfectly with the peak cathode sensitivity of the commercial photo detectors. The developed glasses do not require any special quenching and can be poured easily, which makes them a good candidate for production in various geometries. Here, the glass making conditions, preliminary tests on optical and physical properties of these scintillating, high-density, oxide glasses developed for a novel medical imaging application are reported.

  2. Slow Meteors

    Science.gov (United States)

    Dubs, Martin; Sposetti, Stefano; Spinner, Roger; Booz, Beat

    2017-04-01

    Slow meteors are studied with video observations and spectroscopy. A comparison of their orbits and spectra points to a common origin. Although they do not belong to some meteor stream, they deserve to be studied in more detail. The present paper tries to make a first attempt to characterize the common properties of this class of meteors.

  3. The usefulness of total cholesterol and high density lipoprotein ...

    African Journals Online (AJOL)

    Objective: To determine the usefulness of total cholesterol/high-density lipoprotein cholesterol and/or highdensity lipoprotein cholesterol/total cholesterol ratios in the interpretation of lipid profile result in clinical practice. Methods: This is a prospective case-control study involving 109 diabetics, 98 diabetic hypertensives, 102 ...

  4. Positron camera with high-density avalanche chambers

    International Nuclear Information System (INIS)

    Manfrass, D.; Enghardt, W.; Fromm, W.D.; Wohlfarth, D.; Hennig, K.

    1988-01-01

    The results of an extensive investigation of the properties of high-density avalanche chambers (HIDAC) are presented. This study has been performed in order to optimize the layout of HIDAC detectors, since they are intended to be applied as position sensitive detectors for annihilation radiation in a positron emission tomograph being under construction. (author)

  5. Spontaneous magnetization in high-density quark matter

    DEFF Research Database (Denmark)

    Tsue, Yasuhiko; da Providência, João; Providência, Constanca

    2015-01-01

    It is shown that spontaneous magnetization occurs due to the anomalous magnetic moments of quarks in high-density quark matter under the tensor-type four-point interaction. The spin polarized condensate for each flavor of quark appears at high baryon density, which leads to the spontaneous...

  6. Antioxidant activity of high-density lipoprotein (HDL) using different ...

    African Journals Online (AJOL)

    HDL is a potent antioxidant in terms of inhibition of lipid peroxidation, ROS production and LDL oxidation. These may to some extent add to the antiatherogenic beyond reverse-cholesterol transport properties of HDL. Keywords: high-density lipoprotein; reverse cholesterol transport; apolipoprotein A1; antioxidant; in vitro.

  7. Mendelian Disorders of High-Density Lipoprotein Metabolism

    NARCIS (Netherlands)

    Oldoni, Federico; Sinke, Richard J.; Kuivenhoven, Jan Albert

    2014-01-01

    High-density lipoproteins (HDLs) are a highly heterogeneous and dynamic group of the smallest and densest lipoproteins present in the circulation. This review provides the current molecular insight into HDL metabolism led by articles describing mutations in genes that have a large affect on HDL

  8. High-density QCD phase transitions inside neutron stars: Glitches ...

    Indian Academy of Sciences (India)

    2017-10-09

    Oct 9, 2017 ... ... of different high-density phases and associated phase transitions. We study effectsof density fluctuations during transitions with and without topological defect production and study the effect on pulsar timings due to changing moment of inertia of the star. We also discuss gravitational wave production due ...

  9. High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions

    NARCIS (Netherlands)

    Barter, Philip; Kastelein, John; Nunn, Alistair; Hobbs, Richard

    2003-01-01

    The concentration of high density lipoprotein-cholesterol (HDL-C) has been found consistently to be a powerful negative predictor of premature coronary heart disease (CHD) in human prospective population studies. There is also circumstantial evidence from human intervention studies and direct

  10. Intraocular inflammation following endotamponade with high-density silicone oil.

    NARCIS (Netherlands)

    Theelen, T.; Tilanus, M.A.D.; Klevering, B.J.

    2004-01-01

    BACKGROUND: The use of a mixture of silicone oil and partially fluorinated alkanes (high-density silicone oil) has recently been suggested as intraocular tamponade in complicated retinal detachment of the inferior quadrants. We describe a series of patients who developed a clinical picture

  11. High density plasmas formation in Inertial Confinement Fusion and Astrophysics

    International Nuclear Information System (INIS)

    Martinez-Val, J. M.; Minguez, E.; Velarde, P.; Perlado, J. M.; Velarde, G.; Bravo, E.; Eliezer, S.; Florido, R.; Garcia Rubiano, J.; Garcia-Senz, D.; Gil de la Fe, J. M.; Leon, P. T.; Martel, P.; Ogando, F.; Piera, M.; Relano, A.; Rodriguez, R.; Garcia, C.; Gonzalez, E.; Lachaise, M.; Oliva, E.

    2005-01-01

    In inertially confined fusion (ICF), high densities are required to obtain high gains. In Fast Ignition, a high density, low temperature plasma can be obtained during the compression. If the final temperature reached is low enough, the electrons of the plasma can be degenerate. In degenerate plasmas. Bremsstrahlung emission is strongly suppressed an ignition temperature becomes lower than in classical plasmas, which offers a new design window for ICF. The main difficulty of degenerate plasmas in the compression energy needed for high densities. Besides that, the low specific heat of degenerate electrons (as compared to classical values) is also a problem because of the rapid heating of the plasma. Fluid dynamic evolution of supernovae remnants is a very interesting problem in order to predict the thermodynamical conditions achieved in their collision regions. Those conditions have a strong influence in the emission of light and therefore the detection of such events. A laboratory scale system has been designed reproducing the fluid dynamic field in high energy experiments. The evolution of the laboratory system has been calculated with ARWEN code, 2D Radiation CFD that works with Adaptive Mesh Refinement. Results are compared with simulations on the original system obtained with a 3D SPH astrophysical code. New phenomena at the collision plane and scaling of the laboratory magnitudes will be described. Atomic physics for high density plasmas has been studied with participation in experiments to obtain laser produced high density plasmas under NLTE conditions, carried out at LULI. A code, ATOM3R, has been developed which solves rate equations for optically thin plasmas as well as for homogeneous optically thick plasmas making use of escape factors. New improvements in ATOM3R are been done to calculate level populations and opacities for non homogeneous thick plasmas in NLTE, with emphasis in He and H lines for high density plasma diagnosis. Analytical expression

  12. Noise reduction in muon tomography for detecting high density objects

    Science.gov (United States)

    Benettoni, M.; Bettella, G.; Bonomi, G.; Calvagno, G.; Calvini, P.; Checchia, P.; Cortelazzo, G.; Cossutta, L.; Donzella, A.; Furlan, M.; Gonella, F.; Pegoraro, M.; Rigoni Garola, A.; Ronchese, P.; Squarcia, S.; Subieta, M.; Vanini, S.; Viesti, G.; Zanuttigh, P.; Zenoni, A.; Zumerle, G.

    2013-12-01

    The muon tomography technique, based on multiple Coulomb scattering of cosmic ray muons, has been proposed as a tool to detect the presence of high density objects inside closed volumes. In this paper a new and innovative method is presented to handle the density fluctuations (noise) of reconstructed images, a well known problem of this technique. The effectiveness of our method is evaluated using experimental data obtained with a muon tomography prototype located at the Legnaro National Laboratories (LNL) of the Istituto Nazionale di Fisica Nucleare (INFN). The results reported in this paper, obtained with real cosmic ray data, show that with appropriate image filtering and muon momentum classification, the muon tomography technique can detect high density materials, such as lead, albeit surrounded by light or medium density material, in short times. A comparison with algorithms published in literature is also presented.

  13. Operation and control of high density tokamak reactors

    International Nuclear Information System (INIS)

    Attenberger, S.E.; McAlees, D.G.

    1976-01-01

    The incentive for high density operation of a tokamak reactor is discussed. The plasma size required to attain ignition is determined. Ignition is found to be possible in a relatively small system provided other design criteria are met. These criteria are described and the technology developments and operating procedures required by them are outlined. The parameters for such a system and its dynamic behavior during the operating cycle are also discussed

  14. An atomic impurity in a high density plasma

    International Nuclear Information System (INIS)

    Das, M.P.

    1981-07-01

    We present a self-consistent theory based on the local density functional approach to study the electron structure of an atom imbedded in a high density plasma. We consider a neon atom as an impurity relevant to high compression laser fusion experiments for our analysis and indicate the usefulness of this approach to study level shifts where linear theories like Debye-Hueckel or Thomas-Fermi model will fail. (author)

  15. Evaporation of carbon using electrons of a high density plasma

    International Nuclear Information System (INIS)

    Muhl, S.; Camps, E.; Escobar A, L.; Garcia E, J.L.; Olea, O.

    1999-01-01

    The high density plasmas are used frequently in the preparation of thin films or surface modification, for example to nitridation. In these processes, are used mainly the ions and the neutrals which compose the plasma. However, the electrons present in the plasma are not used, except in the case of chemical reactions induced by collisions, although the electron bombardment usually get hot the work piece. Through the adequate polarization of a conductor material, it is possible to extract electrons from a high density plasma at low pressure, that could be gotten the evaporation of this material. As result of the interaction between the plasma and the electron flux with the vapor produced, this last will be ionized. In this work, it is reported the use of this novelty arrangement to prepare carbon thin films using a high density argon plasma and a high purity graphite bar as material to evaporate. It has been used substrates outside plasma and immersed in the plasma. Also it has been reported the plasma characteristics (temperature and electron density, energy and ions flux), parameters of the deposit process (deposit rate and ion/neutral rate) as well as the properties of the films obtained (IR absorption spectra and UV/Vis, elemental analysis, hardness and refractive index. (Author)

  16. High-density cervical ureaplasma urealyticum colonization in pregnant women

    Directory of Open Access Journals (Sweden)

    Ranđelović Gordana

    2006-01-01

    Full Text Available Background/aim: Ureaplasma urealyticum, a common commensal of the female lower genital tract, has been observed as an important opportunistic pathogen during pregnancy. The aims of this study were to determine the degree of cervical colonization with U. urealyticum in pregnant women with risk pregnancy and in pregnant women with normal term delivery and to evaluate the correlation between high-density cervical U. urealyticum colonization and premature rupture of membranes (PROM as well. Methods. This research was conducted on the samples comprising 130 hospitalized pregnant women with threatening preterm delivery and premature rupture of membranes. The control group consisted of 39 pregnant women with term delivery without PROM. In addition to standard bacteriological examination and performing direct immunofluorescence test to detect Chlamydia trachomatis, cervical swabs were also examined for the presence of U. urealyticum and Mycoplasma hominis by commercially available Mycofast Evolution 2 test (International Microbio, France. Results. The number of findings with isolated high-density U. urealyticum in the target group was 69 (53.08%, while in the control group was 14 (35.90%. Premature rupture of membranes (PROM occurred in 43 (33.08% examinees: 29 were pPROM, and 14 were PROM. The finding of U.urealyticum ≥104 was determined in 25 (58.14% pregnant women with rupture, 17 were pPROM, and 8 were PROM. There was statistically significant difference in the finding of high-density U. urealyticum between the pregnant women with PROM and the control group (χ² = 4.06, p < 0.05. U. urealyticum was predominant bacterial species found in 62.79% of isolates in the PROM cases, while in 32.56% it was isolated alone. Among the 49 pregnant women with preterm delivery, pPROM occurred in 29 (59.18% examinees, and in 70.83% of pregnant women with findings of high-density U. urealyticum pPROM was observed. Conclusion. Cervical colonization with U

  17. Characterization of the high density plasma etching process of CCTO thin films for the fabrication of very high density capacitors

    Energy Technology Data Exchange (ETDEWEB)

    Altamore, C; Tringali, C; Sparta' , N; Marco, S Di; Grasso, A; Ravesi, S [STMicroelectronics, Industial and Multi-segment Sector R and D, Catania (Italy)

    2010-02-15

    In this work the feasibility of CCTO (Calcium Copper Titanate) patterning by etching process is demonstrated and fully characterized in a hard to etch materials etcher. CCTO sintered in powder shows a giant relative dielectric constant (10{sup 5}) measured at 1 MHz at room temperature. This feature is furthermore coupled with stability from 10{sup 1} Hz to 10{sup 6} Hz in a wide temperature range (100K - 600K). In principle, this property can allow to fabricate very high capacitance density condenser. Due to its perovskite multi-component structure, CCTO can be considered a hard to etch material. For high density capacitor fabrication, CCTO anisotropic etching is requested by using high density plasma. The behavior of etched CCTO was studied in a HRe- (High Density Reflected electron) plasma etcher using Cl{sub 2}/Ar chemistry. The relationship between the etch rate and the Cl{sub 2}/Ar ratio was also studied. The effects of RF MHz, KHz Power and pressure variation, the impact of HBr addiction to the Cl{sub 2}/Ar chemistry on the CCTO etch rate and on its selectivity to Pt and photo resist was investigated.

  18. The application of high density tape recording to image processing

    Science.gov (United States)

    Heffner, P.

    1976-01-01

    The Image Processing Facility at Goddard Space Flight Center has the requirement to move volumes of digital data (100 billion data bits per day) that exceed the capacity of conventional computer tape. This paper presents the requirements for a high-density digital tape recorder compatible with conventional computer systems. The steps leading to the formulation of these requirements are described. The use and interaction of the recorder with the various elements in the facility are treated. The formulation of the requirements resulted in the selection of a tape transport modified for digital serial-in, serial-out operation. This selection followed a competitive procurement action.

  19. High Density Thermal Energy Storage with Supercritical Fluids

    Science.gov (United States)

    Ganapathi, Gani B.; Wirz, Richard

    2012-01-01

    A novel approach to storing thermal energy with supercritical fluids is being investigated, which if successful, promises to transform the way thermal energy is captured and utilized. The use of supercritical fluids allows cost-affordable high-density storage with a combination of latent heat and sensible heat in the two-phase as well as the supercritical state. This technology will enhance penetration of several thermal power generation applications and high temperature water for commercial use if the overall cost of the technology can be demonstrated to be lower than the current state-of-the-art molten salt using sodium nitrate and potassium nitrate eutectic mixtures.

  20. Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery

    Science.gov (United States)

    McMahon, Kaylin M.; Mutharasan, R. Kannan; Tripathy, Sushant; Veliceasa, Dorina; Bobeica, Mariana; Shumaker, Dale K.; Luthi, Andrea J.; Helfand, Brian T.; Ardehali, Hossein; Mirkin, Chad A.; Volpert, Olga; Thaxton, C. Shad

    2014-01-01

    We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy which combines lipid-based nucleic acid transfection strategies with HDL biomimicry. For proof-of-concept, HDL AuNPs are shown to adsorb antisense cholesterylated DNA. The conjugates are internalized by human cells, can be tracked within cells using transmission electron microscopy (TEM), and regulate target gene expression. Overall, the ability to directly image the AuNP core within cells, the chemical tailorability of the HDL AuNP platform, and the potential for cell-specific targeting afforded by HDL biomimicry make this platform appealing for nucleic acid delivery. PMID:21319839

  1. Viscosity and attenuation of sound wave in high density deuterium

    International Nuclear Information System (INIS)

    Inoue, Kazuko; Ariyasu, Tomio

    1985-01-01

    The penetration of low frequency sound wave into the fuel deuterium is discussed as for laser fusion. The sound velocity and the attenuation constant due to viscosity are calculated for high density (n = 10 24 -- 10 27 cm -3 , T = 10 -1 -- 10 4 eV) deuterium. The shear viscosity of free electron gas and the bulk viscosity due to ion-ion interaction mainly contribute to the attenuation of sound wave. The sound wave of the frequency below 10 10 Hz can easily penetrate through the compressed fuel deuterium of diameter 1 -- 10 3 μm. (author)

  2. Biofuels Barrier Properties of Polyamide 6 and High Density Polyethylene

    OpenAIRE

    Fillot L.-A.; Ghiringhelli S.; Prebet C.; Rossi S.

    2015-01-01

    In this paper, a comparison of the biofuels barrier properties of PolyAmide 6 (PA6) and High Density PolyEthylene (HDPE) is presented. Model fuels were prepared as mixtures of toluene, isooctane and ethanol, the ethanol volume fraction varying between 0% and 100%. Barrier properties were determined at 40°C by gravimetric techniques or gas chromatography measurements, and it was shown that polyamide 6 permeability is lower than that of polyethylene on a wide range of ethanol contents up to 85%...

  3. Ultra-Stretchable Interconnects for High-Density Stretchable Electronics

    Directory of Open Access Journals (Sweden)

    Salman Shafqat

    2017-09-01

    Full Text Available The exciting field of stretchable electronics (SE promises numerous novel applications, particularly in-body and medical diagnostics devices. However, future advanced SE miniature devices will require high-density, extremely stretchable interconnects with micron-scale footprints, which calls for proven standardized (complementary metal-oxide semiconductor (CMOS-type process recipes using bulk integrated circuit (IC microfabrication tools and fine-pitch photolithography patterning. Here, we address this combined challenge of microfabrication with extreme stretchability for high-density SE devices by introducing CMOS-enabled, free-standing, miniaturized interconnect structures that fully exploit their 3D kinematic freedom through an interplay of buckling, torsion, and bending to maximize stretchability. Integration with standard CMOS-type batch processing is assured by utilizing the Flex-to-Rigid (F2R post-processing technology to make the back-end-of-line interconnect structures free-standing, thus enabling the routine microfabrication of highly-stretchable interconnects. The performance and reproducibility of these free-standing structures is promising: an elastic stretch beyond 2000% and ultimate (plastic stretch beyond 3000%, with <0.3% resistance change, and >10 million cycles at 1000% stretch with <1% resistance change. This generic technology provides a new route to exciting highly-stretchable miniature devices.

  4. Loop formation of microtubules during gliding at high density

    International Nuclear Information System (INIS)

    Liu, Lynn; Ross, Jennifer L; Tuezel, Erkan

    2011-01-01

    The microtubule cytoskeleton, including the associated proteins, forms a complex network essential to multiple cellular processes. Microtubule-associated motor proteins, such as kinesin-1, travel on microtubules to transport membrane bound vesicles across the crowded cell. Other motors, such as cytoplasmic dynein and kinesin-5, are used to organize the cytoskeleton during mitosis. In order to understand the self-organization processes of motors on microtubules, we performed filament-gliding assays with kinesin-1 motors bound to the cover glass with a high density of microtubules on the surface. To observe microtubule organization, 3% of the microtubules were fluorescently labeled to serve as tracers. We find that microtubules in these assays are not confined to two dimensions and can cross one other. This causes microtubules to align locally with a relatively short correlation length. At high density, this local alignment is enough to create 'intersections' of perpendicularly oriented groups of microtubules. These intersections create vortices that cause microtubules to form loops. We characterize the radius of curvature and time duration of the loops. These different behaviors give insight into how crowded conditions, such as those in the cell, might affect motor behavior and cytoskeleton organization.

  5. Multiplexed, high density electrophysiology with nanofabricated neural probes.

    Directory of Open Access Journals (Sweden)

    Jiangang Du

    Full Text Available Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable.

  6. Manufacture of sintered bricks of high density from beryllium oxide

    International Nuclear Information System (INIS)

    Pointud, R.; Rispal, Ch.; Le Garec, M.

    1959-01-01

    Beryllium oxide bricks of nuclear purity 100 x 100 x 50 and 100 x 100 x 100 mm of very high density (between 2.85 and 3.00) are manufactured by sintering under pressure in graphite moulds at temperatures between 1,750 and 1,850 deg. C, and under a pressure of 150 kg/cm 2 . The physico-chemical state of the saw material is of considerable importance with regard to the success of the sintering operation. In addition, a study of the sintering of a BeO mixture with 3 to 5 per cent of boron introduced in the form of boric acid, boron carbide or elementary boron shows that high densities can only be obtained by sintering under pressure. For technical reasons of manufacture, only the mixture based on boron carbide is used. The sintering is carried out in graphite moulds at 1500 deg. C under 150 kg/cm 2 pressure, and bricks can be obtained with density between 2,85 and 2,90. Laboratory studies and the industrial manufacture of various sinters are described in detail. (author) [fr

  7. Development of technology of high density LEU dispersion fuel fabrication

    International Nuclear Information System (INIS)

    Wiencek, T.; Totev, T.

    2007-01-01

    Advanced Materials Fabrication Facilities at Argonne National Laboratory have been involved in development of LEU dispersion fuel for research and test reactors from the beginning of RERTR program. This paper presents development of technology of high density LEU dispersion fuel fabrication for full size plate type fuel elements. A brief description of Advanced Materials Fabrication Facilities where development of the technology was carried out is given. A flow diagram of the manufacturing process is presented. U-Mo powder was manufactured by the rotating electrode process. The atomization produced a U-Mo alloy powder with a relatively uniform size distribution and a nearly spherical shape. Test plates were fabricated using tungsten and depleted U-7 wt.% Mo alloy, 4043 Al and Al-2 wt% Si matrices with Al 6061 aluminum alloy for the cladding. During the development of the technology of manufacturing of full size high density LEU dispersion fuel plates special attention was paid to meet the required homogeneity, bonding, dimensions, fuel out of zone and other mechanical characteristics of the plates.

  8. Multiplexed, high density electrophysiology with nanofabricated neural probes.

    Science.gov (United States)

    Du, Jiangang; Blanche, Timothy J; Harrison, Reid R; Lester, Henry A; Masmanidis, Sotiris C

    2011-01-01

    Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable.

  9. Characterization of High Density Concrete by Ultrasonic Goniometer

    International Nuclear Information System (INIS)

    Suhairy Sani; Mohamad Pauzi Ismail; Noor Azreen Masenwat; Nasharuddin Isa; Mohamad Haniza Mahmud

    2014-01-01

    This paper described the results of ultrasonic goniometer measurements on concrete containing hematite. Local hematite stones were used as aggregates to produce high density concrete for application in X-and gamma shielding. Concrete cube samples (150 mm x 150 mm x 150 mm) containing hematite as coarse aggregates were prepared by changing mix ratio, water to cement ratio (w/ c) and types of fine aggregate. All samples were cured in water for 7 days. After 28 days of casting, the concrete cubes were then cut into small size of about 10 mm x 20 mm x 30 mm so that it can be fitted into goniometer specimen holder. From this measurement, longitudinal, shear and surface Rayleigh waves in the concrete can be determined. The measurement results are explained and discussed. (author)

  10. High-density percutaneous chronic connector for neural prosthetics

    Science.gov (United States)

    Shah, Kedar G.; Bennett, William J.; Pannu, Satinderpall S.

    2015-09-22

    A high density percutaneous chronic connector, having first and second connector structures each having an array of magnets surrounding a mounting cavity. A first electrical feedthrough array is seated in the mounting cavity of the first connector structure and a second electrical feedthrough array is seated in the mounting cavity of the second connector structure, with a feedthrough interconnect matrix positioned between a top side of the first electrical feedthrough array and a bottom side of the second electrical feedthrough array to electrically connect the first electrical feedthrough array to the second electrical feedthrough array. The two arrays of magnets are arranged to attract in a first angular position which connects the first and second connector structures together and electrically connects the percutaneously connected device to the external electronics, and to repel in a second angular position to facilitate removal of the second connector structure from the first connector structure.

  11. Method of producing high density silicon carbide product

    International Nuclear Information System (INIS)

    1981-01-01

    A method of sintering silicon carbide powders containing boron or boron - containing compounds as densification aids to produce a high-density silicon carbide ceramic material is described. It has been found that higher densification can be obtained by sintering the powders in an atmosphere containing boron. Boron may be introduced in the form of a gas, e.g. boron trichloride, mixed with the inert gas used, i.e. nitrogen, argon or helium, or boron compounds, e.g. boron carbide, may be applied to the interior of the sintering chamber as solutions or slurries. Alternatively a boron compound, per se, in the sintering chamber, or furnace components containing a significant amount of boron may be used. (U.K.)

  12. Radiation resistance testing of high-density polyethylene

    International Nuclear Information System (INIS)

    Dougherty, D.R.; Adams, J.W.

    1983-01-01

    Mechanical tests following gamma inrradiation and creep tests during irradiation have been conducted on high-density polyethylene (HDPE) to assess the adequacy of this material for use in high-integrity containers (HICs). These tests were motivated by experience in nuclear power plants in which polyethylene electrical insulation detoriorated more rapidly than expected due to radiation-induced oxidation. This suggested that HDPE HICs used for radwaste disposal might degrade more rapidly than would be expected in the absence of the radiation field. Two types of HDPE, a highly cross-linked rotationally molded material and a non-cross-linked blow molded material, were used in these tests. Gamma-ray irradiations were performed at several dose rates in environments of air, Barnwell and Hanford backfill soils, and ion-exchange resins. The results of tensile and bend testing on these materials following irradiation will be presented along with preliminary results on creep during irradiation

  13. Evaluation of the radiation resistance of high-density polyethylene

    International Nuclear Information System (INIS)

    Dougherty, D.R.; Adams, J.W.; Barletta, R.R.

    1984-03-01

    Mechanical tests following gamma irradiation and creep tests during irradiation have been conducted on high-density polyethylene (HDPE) to provide data to help assess the adequacy of this material for use in high integrity containers (HICs). Two types of HDPE, a highly cross-linked rotationally molded material and a non-cross-linked blow molded material, were used in these tests. Gamma-ray irradiations were performed at several dose rates in environments of air, Barnwell and Hanford backfill soils, and ion-exchange resins. The results of tensile and bend tests on these materials following irradiation are presented along with results on creep during irradiation. 8 references, 9 figures, 2 tables

  14. Corrosion of high-density sintered tungsten alloys. Part 2

    International Nuclear Information System (INIS)

    Batten, J.J.; Moore, B.T.

    1988-12-01

    The behaviour of four high-density sintered tungsten alloys has been evluated and compared with that of pure tungsten. Rates of corrosion during the cyclic humidity and the salt mist tests were ascertained from weight loss measurements. Insight into the corrosion mechanism was gained from the nature of the corrosion products and an examination of the corroded surfaces. In the tests, the alloy 95% W, 2.5% Ni, 1.5% Fe was the most corrosion resistant. The data showed that copper as an alloying element accelerates corrosion of tungsten alloys. Both attack on the tungsten particles and the binder phase were observed together with tungsten grain loss. 6 refs., 3 tabs.,

  15. Scoping study. High density polyethylene (HDPE) in salstone service

    Energy Technology Data Exchange (ETDEWEB)

    Phifer, Mark A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2005-02-18

    An evaluation of the use of high density polyethylene (HDPE) geomembranes in Saltstone service has been conducted due to the potential benefits that could be derived from such usage. HDPE is one of the simplest hydrocarbon polymers and one of the most common polymers utilized in the production of geomembranes, which means that its costs are relatively low. Additionally, HDPE geomembranes have an extremely low permeability and an extremely low water vapor diffusional flux, which means that it is a good barrier to contaminant transport. The primary consideration in association with HDPE geomembranes in Saltstone service is the potential impact of Saltstone on the degradation of the HDPE geomembranes. Therefore, the evaluation documented herein has primarily focused upon the potential HDPE degradation in Saltstone service.

  16. High-Density Lipoproteins and the Immune System

    Directory of Open Access Journals (Sweden)

    Hidesuke Kaji

    2013-01-01

    Full Text Available High-density lipoprotein (HDL plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-inflammation behavior, and the mechanisms by which HDL interacts with components of the innate and adaptive immune systems. Genome-wide association studies (GWAS and proteomic studies have elucidated important molecules involved in the interaction between HDL and the immune system. An understanding of these mechanisms is expected to be useful for the prevention and treatment of chronic inflammation due to metabolic syndrome, atherosclerosis, or various autoimmune diseases.

  17. A distributed current stimulator ASIC for high density neural stimulation.

    Science.gov (United States)

    Jeong Hoan Park; Chaebin Kim; Seung-Hee Ahn; Tae Mok Gwon; Joonsoo Jeong; Sang Beom Jun; Sung June Kim

    2016-08-01

    This paper presents a novel distributed neural stimulator scheme. Instead of a single stimulator ASIC in the package, multiple ASICs are embedded at each electrode site for stimulation with a high density electrode array. This distributed architecture enables the simplification of wiring between electrodes and stimulator ASIC that otherwise could become too complex as the number of electrode increases. The individual ASIC chip is designed to have a shared data bus that independently controls multiple stimulating channels. Therefore, the number of metal lines is determined by the distributed ASICs, not by the channel number. The function of current steering is also implemented within each ASIC in order to increase the effective number of channels via pseudo channel stimulation. Therefore, the chip area can be used more efficiently. The designed chip was fabricated with area of 0.3 mm2 using 0.18 μm BCDMOS process, and the bench-top test was also conducted to validate chip performance.

  18. High density thermite mixture for shaped charge ordnance disposal

    Directory of Open Access Journals (Sweden)

    Tamer Elshenawy

    2017-10-01

    Full Text Available The effect of thermite mixture based on aluminum and ferric oxides for ammunition neutralization has been studied and tested. Thermochemical calculations have been carried out for different percentage of Al using Chemical Equilibrium Code to expect the highest performance thermite mixture used for shaped charge ordnance disposal. Densities and enthalpy of different formulations have been calculated and demonstrated. The optimized thermite formulation has been prepared experimentally using cold iso-static pressing technique, which exhibited relatively high density and high burning rate thermite mixture. The produced green product compacted powder mixture was tested against small caliber shaped charge bomblet for neutralization. Theoretical and experimental results showed that the prepared thermite mixture containing 33% of aluminum as a fuel with ferric oxide can be successfully used for shaped charge ordnance disposal.

  19. High-current discharge channel contraction in high density gas

    International Nuclear Information System (INIS)

    Rutberg, Ph. G.; Bogomaz, A. A.; Pinchuk, M. E.; Budin, A. V.; Leks, A. G.; Pozubenkov, A. A.

    2011-01-01

    Research results for discharges at current amplitudes of 0.5-1.6 MA and current rise rate of ∼10 10 A/s are presented. The discharge is performed in the hydrogen environment at the initial pressure of 5-35 MPa. Initiation is implemented by a wire explosion. The time length of the first half-period of the discharge current is 70-150 μs. Under such conditions, discharge channel contraction is observed; the contraction is followed by soft x-ray radiation. The phenomena are discussed, which are determined by high density of the gas surrounding the discharge channel. These phenomena are increase of the current critical value, where the channel contraction begins and growth of temperature in the axis region of the channel, where the initial density of the gas increases.

  20. High Density Memory Based on Quantum Device Technology

    Science.gov (United States)

    vanderWagt, Paul; Frazier, Gary; Tang, Hao

    1995-01-01

    We explore the feasibility of ultra-high density memory based on quantum devices. Starting from overall constraints on chip area, power consumption, access speed, and noise margin, we deduce boundaries on single cell parameters such as required operating voltage and standby current. Next, the possible role of quantum devices is examined. Since the most mature quantum device, the resonant tunneling diode (RTD) can easily be integrated vertically, it naturally leads to the issue of 3D integrated memory. We propose a novel method of addressing vertically integrated bistable two-terminal devices, such as resonant tunneling diodes (RTD) and Esaki diodes, that avoids individual physical contacts. The new concept has been demonstrated experimentally in memory cells of field effect transistors (FET's) and stacked RTD's.

  1. Measurements of uranium mass confined in high density plasmas

    Science.gov (United States)

    Stoeffler, R. C.

    1976-01-01

    An X-ray absorption method for measuring the amount of uranium confined in high density, rf-heated uranium plasmas is described. A comparison of measured absorption of 8 keV X-rays with absorption calculated using Beer Law indicated that the method could be used to measure uranium densities from 3 times 10 to the 16th power atoms/cu cm to 5 times 10 to the 18th power atoms/cu cm. Tests were conducted to measure the density of uranium in an rf-heated argon plasma with UF6 infection and with the power to maintain the discharge supplied by a 1.2 MW rf induction heater facility. The uranium density was measured as the flow rate through the test chamber was varied. A maximum uranium density of 3.85 times 10 to the 17th power atoms/cu cm was measured.

  2. The Pulsed High Density Experiment (PHDX) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Slough, John P. [Univ. of Washington, Seattle, WA (United States); Andreason, Samuel [Univ. of Washington, Seattle, WA (United States)

    2017-04-27

    The purpose of this paper is to present the conclusions that can be drawn from the Field Reversed Configuration (FRC) formation experiments conducted on the Pulsed High Density experiment (PHD) at the University of Washington. The experiment is ongoing. The experimental goal for this first stage of PHD was to generate a stable, high flux (>10 mWb), high energy (>10 KJ) target FRC. Such results would be adequate as a starting point for several later experiments. This work focuses on experimental implementation and the results of the first four month run. Difficulties were encountered due to the initial on-axis plasma ionization source. Flux trapping with this ionization source acting alone was insufficient to accomplish experimental objectives. Additional ionization methods were utilized to overcome this difficulty. A more ideal plasma source layout is suggested and will be explored during a forthcoming work.

  3. Simulation of extrusion of high density polyethylene tubes

    Directory of Open Access Journals (Sweden)

    Koutelieris Antonios

    2017-01-01

    Full Text Available The production of extruded polyethylene films rods, tubes and pipes is a typical industrial process that has been extensively investigated over many years. In this study the extrusion of High Density Polyethylene (HDPE tubes was simulated by using the 3D finite element simulation software StarCCM+®. The simulation was applied in order to examine the influence of design and operational parameters on the characteristics and the soundness of the tube and for optimizing the overall quality of the product. Two alternative die configurations were studied; one with a four inputs head and the other with an eight inputs head. From the results obtained it is concluded that extrusion with the eight inputs head die design results in better overall pipe quality; this design was implemented successfully in an industrial production line.

  4. Preparations of high density (Th,U)O2 pellets

    International Nuclear Information System (INIS)

    Akabori, Mitsuo; Ikawa, Katsuichi

    1986-07-01

    Preparations of high density and homogeneous (Th,U)O 2 pellets by a powder metallurgy method were examined. (Th,U)O 2 powders were prepared by calcining coprecipitates of ammonium uranate and thorium hydroxide derived from nitrates and mixed sols, and by calcining mixed oxalates precipitated from nitrates. (Th,U)O 2 pellets were characterized with respect to sinterability, lattice parameter, microstructure, homogeneity and stoichiometry. Sintering atmospheres had a significant effect upon all the properties of the derived pellets. The sinterability of (Th,U)O 2 was most favourable in oxidizing and reducing atmospheres for ThO 2 -rich and UO 2 -rich compositions, respectively, and can be enhanced by presence of water vapour in sintering atmospheres. In addition, highly homogeneous (Th,U)O 2 pellets with 99 % in theoretical density were derived from the sol powders. (author)

  5. Single-Readout High-Density Memristor Crossbar

    KAUST Repository

    Zidan, M. A.

    2016-01-07

    High-density memristor-crossbar architecture is a very promising technology for future computing systems. The simplicity of the gateless-crossbar structure is both its principal advantage and the source of undesired sneak-paths of current. This parasitic current could consume an enormous amount of energy and ruin the readout process. We introduce new adaptive-threshold readout techniques that utilize the locality and hierarchy properties of the computer-memory system to address the sneak-paths problem. The proposed methods require a single memory access per pixel for an array readout. Besides, the memristive crossbar consumes an order of magnitude less power than state-of-the-art readout techniques.

  6. The stability of the High-Density Z-Pinch

    International Nuclear Information System (INIS)

    Glasser, A.H.; Nebel, R.A.

    1989-01-01

    Fiber-initiated High Density Z-Pinches at Los Alamos, NRL, and Karlsruhe have shown anomalously good stability. Kink modes are never seen, and sausage modes are at least delayed until late in the discharge. The success of these devices in reaching fusion conditions may depend on maintaining and understanding this anomalous stability. We have developed two numerical methods to study the stability in the regime where fluid theory is valid. While our methods are applicable to all modes, we will describe them only for the m = 0 sausage mode. The appearance of sausage modes late in the discharge and the total absence of kink modes suggest that an understanding of sausage modes is more urgent, and it is also simpler. 14 refs., 8 figs

  7. Methods and systems for rapid prototyping of high density circuits

    Science.gov (United States)

    Palmer, Jeremy A [Albuquerque, NM; Davis, Donald W [Albuquerque, NM; Chavez, Bart D [Albuquerque, NM; Gallegos, Phillip L [Albuquerque, NM; Wicker, Ryan B [El Paso, TX; Medina, Francisco R [El Paso, TX

    2008-09-02

    A preferred embodiment provides, for example, a system and method of integrating fluid media dispensing technology such as direct-write (DW) technologies with rapid prototyping (RP) technologies such as stereolithography (SL) to provide increased micro-fabrication and micro-stereolithography. A preferred embodiment of the present invention also provides, for example, a system and method for Rapid Prototyping High Density Circuit (RPHDC) manufacturing of solderless connectors and pilot devices with terminal geometries that are compatible with DW mechanisms and reduce contact resistance where the electrical system is encapsulated within structural members and manual electrical connections are eliminated in favor of automated DW traces. A preferred embodiment further provides, for example, a method of rapid prototyping comprising: fabricating a part layer using stereolithography and depositing thermally curable media onto the part layer using a fluid dispensing apparatus.

  8. Sound waves and shock waves in high-density deuterium

    International Nuclear Information System (INIS)

    Inoue, Kazuko; Ariyasu, Tomio

    1991-01-01

    The possibility of compressing the cryogenic hollow pellet of inertial confinement nuclear fusion with multiple adiabatic shock waves is discussed, on the basis of the estimation of the properties of a high-density deuterium plasma (10 24 -10 27 cm -3 , 10 -1 -10 4 eV), such as the velocity and the attenuation constant of the adiabatic sound wave, the width of the shock wave, and the surface tension. It is found that in the course of compression the wavelength of the adiabatic sound wave and the width of the weak shock wave sometimes become comparable to or exceed the fuel shell width of the pellet, and that the surface tension is negative. These results show that it is rather difficult to compress stably the hollow pellet with successive weak shock waves. (author)

  9. The glass transition in high-density amorphous ice.

    Science.gov (United States)

    Loerting, Thomas; Fuentes-Landete, Violeta; Handle, Philip H; Seidl, Markus; Amann-Winkel, Katrin; Gainaru, Catalin; Böhmer, Roland

    2015-01-01

    There has been a long controversy regarding the glass transition in low-density amorphous ice (LDA). The central question is whether or not it transforms to an ultraviscous liquid state above 136 K at ambient pressure prior to crystallization. Currently, the most widespread interpretation of the experimental findings is in terms of a transformation to a superstrong liquid above 136 K. In the last decade some work has also been devoted to the study of the glass transition in high-density amorphous ice (HDA) which is in the focus of the present review. At ambient pressure HDA is metastable against both ice I and LDA, whereas at > 0.2 GPa HDA is no longer metastable against LDA, but merely against high-pressure forms of crystalline ice. The first experimental observation interpreted as the glass transition of HDA was made using in situ methods by Mishima, who reported a glass transition temperature T g of 160 K at 0.40 GPa. Soon thereafter Andersson and Inaba reported a much lower glass transition temperature of 122 K at 1.0 GPa. Based on the pressure dependence of HDA's T g measured in Innsbruck, we suggest that they were in fact probing the distinct glass transition of very high-density amorphous ice (VHDA). Very recently the glass transition in HDA was also observed at ambient pressure at 116 K. That is, LDA and HDA show two distinct glass transitions, clearly separated by about 20 K at ambient pressure. In summary, this suggests that three glass transition lines can be defined in the p-T plane for LDA, HDA, and VHDA.

  10. Biominetic High Density Lipoproteins for the Delivery of Therapeutic Oligonucleotides

    Science.gov (United States)

    Tripathy, Sushant

    Advances in nanotechnology have brought about novel inorganic and hybrid nanoparticles with unique physico-chemical properties that make them suitable for a broad range of applications---from nano-circuitry to drug delivery. A significant part of those advancements have led to ground-breaking discoveries that have changed the approaches to formulation of therapeutics against diseases, such as cancer. Now-a-days the focus does not lie solely on finding a candidate small-molecule therapeutic with minimal adverse effects, but researchers are looking up to nanoparticles to improve biodistribution and biocompatibility profile of clinically proven therapeutics. The plethora of conjugation chemistries offered by currently extant inorganic nanoparticles have, in recent years, led to great leaps in the field of biomimicry---a modality that promises high biocompatibility. Further, in the pursuit of highly specific therapeutic molecules, researchers have turned to silencing oligonucleotides and some have already brought together the strengths of nanoparticles and silencing oligonucleotides in search of an efficacious therapy for cancer with minimal adverse effects. This dissertation work focuses on such a biomimetic platform---a gold nanoparticle based high density lipoprotein biomimetic (HDL NP), for the delivery of therapeutic oligonucleotides. The first chapter of this body of work introduces the molecular target of the silencing oligonucleotides---VEGFR2, and its role in the progression of solid tumor cancers. The background information also covers important aspects of natural high density lipoproteins (HDL), especially their innate capacity to bind and deliver exogenous and endogenous silencing oligonucleotides to tissues that express their high affinity receptor SRB1. We subsequently describe the synthesis of the biomimetic HDL NP and its oligonucleotide conjugates, and establish their biocompatibility. Further on, experimental data demonstrate the efficacy of silencing

  11. Enabling Airspace Integration for High Density Urban Air Mobility

    Science.gov (United States)

    Mueller, Eric Richard

    2017-01-01

    Aviation technologies and concepts have reached a level of maturity that may soon enable an era of on-demand mobility (ODM) fueled by quiet, efficient, and largely automated air taxis. However, successfully bringing such a system to fruition will require introducing orders of magnitude more aircraft to a given airspace volume than can be accommodated by the traditional air traffic control system, among other important technical challenges. The airspace integration problem is further compounded by requirements to set aside appropriate ground infrastructure for take-off and landing areas and ensuring these new aircraft types and their operations do not burden traditional airspace users and air traffic control. These challenge for ODM may be significantly reduced by extending the concepts and technologies developed to manage small unmanned aircraft systems (UAS) at low altitude the UAS traffic management (UTM) system to higher altitudes and aircraft with humans onboard in controlled airspace, or by equipping ODM aircraft with advanced sensors, algorithms, and interfaces. The precedent of operational freedom inherent in visual flight rules and the technologies developed for large UAS and commercial aircraft automation will contribute to the evolution of an ODM system enabled by UTM. This paper describes the set of air traffic services, normally provided by the traditional air traffic system, that an ODM system would implement to achieve the high densities needed for ODMs economic viability. Finally, the paper proposes a framework for integrating, evaluating, and deploying low-, medium-, and high-density ODM concepts that build on each other to ensure operational and economic feasibility at every step.

  12. Scalp and Source Power Topography in Sleepwalking and Sleep Terrors: A High-Density EEG Study

    Science.gov (United States)

    Castelnovo, Anna; Riedner, Brady A.; Smith, Richard F.; Tononi, Giulio; Boly, Melanie; Benca, Ruth M.

    2016-01-01

    Study Objectives: To examine scalp and source power topography in sleep arousals disorders (SADs) using high-density EEG (hdEEG). Methods: Fifteen adult subjects with sleep arousal disorders (SADs) and 15 age- and gender-matched good sleeping healthy controls were recorded in a sleep laboratory setting using a 256 channel EEG system. Results: Scalp EEG analysis of all night NREM sleep revealed a localized decrease in slow wave activity (SWA) power (1–4 Hz) over centro-parietal regions relative to the rest of the brain in SADs compared to good sleeping healthy controls. Source modelling analysis of 5-minute segments taken from N3 during the first half of the night revealed that the local decrease in SWA power was prominent at the level of the cingulate, motor, and sensori-motor associative cortices. Similar patterns were also evident during REM sleep and wake. These differences in local sleep were present in the absence of any detectable clinical or electrophysiological sign of arousal. Conclusions: Overall, results suggest the presence of local sleep differences in the brain of SADs patients during nights without clinical episodes. The persistence of similar topographical changes in local EEG power during REM sleep and wakefulness points to trait-like functional changes that cross the boundaries of NREM sleep. The regions identified by source imaging are consistent with the current neurophysiological understanding of SADs as a disorder caused by local arousals in motor and cingulate cortices. Persistent localized changes in neuronal excitability may predispose affected subjects to clinical episodes. Citation: Castelnovo A, Riedner BA, Smith RF, Tononi G, Boly M, Benca RM. Scalp and source power topography in sleepwalking and sleep terrors: a high-density EEG study. SLEEP 2016;39(10):1815–1825. PMID:27568805

  13. Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia

    Science.gov (United States)

    Colombo, Michele A.; Ramautar, Jennifer R.; Wei, Yishul; Gomez-Herrero, Germán; Stoffers, Diederick; Wassing, Rick; Benjamins, Jeroen S.; Tagliazucchi, Enzo; van der Werf, Ysbrand D.; Cajochen, Christian; Van Someren, Eus J.W.

    2016-01-01

    Study Objectives: Although daytime complaints are a defining characteristic of insomnia, most EEG studies evaluated sleep only. We used high-density electroencephalography to investigate wake resting state oscillations characteristic of insomnia disorder (ID) at a fine-grained spatiospectral resolution. Methods: A case-control assessment during eyes open (EO) and eyes closed (EC) was performed in a laboratory for human physiology. Participants (n = 94, 74 female, 21–70 y) were recruited through www.sleepregistry.nl: 51 with ID, according to DSM-5 and 43 matched controls. Exclusion criteria were any somatic, neurological or psychiatric condition. Group differences in the spectral power topographies across multiple frequencies (1.5 to 40 Hz) were evaluated using permutation-based inference with Threshold-Free Cluster-Enhancement, to correct for multiple comparisons. Results: As compared to controls, participants with ID showed less power in a narrow upper alpha band (11–12.7 Hz, peak: 11.7 Hz) over bilateral frontal and left temporal regions during EO, and more power in a broad beta frequency range (16.3–40 Hz, peak: 19 Hz) globally during EC. Source estimates suggested global rather than cortically localized group differences. Conclusions: The widespread high power in a broad beta band reported previously during sleep in insomnia is present as well during eyes closed wakefulness, suggestive of a round-the-clock hyperarousal. Low power in the upper alpha band during eyes open is consistent with low cortical inhibition and attentional filtering. The fine-grained HD-EEG findings suggest that, while more feasible than PSG, wake EEG of short duration with a few well-chosen electrodes and frequency bands, can provide valuable features of insomnia. Citation: Colombo MA, Ramautar JR, Wei Y, Gomez-Herrero G, Stoffers D, Wassing R, Benjamins JS, Tagliazucchi E, van der Werf YD, Cajochen C, Van Someren EJW. Wake high-density electroencephalographic spatiospectral

  14. High density operation on the HT-7 superconducting tokamak

    International Nuclear Information System (INIS)

    Xiang Gao

    2000-01-01

    The structure of the operation region has been studied in the HT-7 superconducting tokamak, and progress on the extension of the HT-7 ohmic discharge operation region is reported. A density corresponding to 1.2 times the Greenwald limit was achieved by RF boronization. The density limit appears to be connected to the impurity content and the edge parameters, so the best results are obtained with very clean plasmas and peaked electron density profiles. The peaking factors of electron density profiles for different current and line averaged densities were observed. The density behaviour and the fuelling efficiency for gas puffing (20-30%), pellet injection (70-80%) and molecular beam injection (40-50%) were studied. The core crash sawteeth and MHD behaviour, which were induced by an injected pellet, were observed and the events correlated with the change of current profile and reversed magnetic shear. The MARFE phenomena on HT-7 are summarized. The best correlation has been found between the total input ohmic power and the product of the edge line averaged density and Z eff . HT-7 could be easily operated in the high density region MARFE-free using RF boronization. (author)

  15. High Density Lipoprotein Cholesterol Increasing Therapy: The Unmet Cardiovascular Need

    Science.gov (United States)

    Cimmino, Giovanni; Ciccarelli, Giovanni; Morello, Alberto; Ciccarelli, Michele; Golino, Paolo

    2015-01-01

    Despite aggressive strategies are now available to reduce LDL-cholesterol, the risk of cardiovascular events in patients with coronary artery disease remains substantial. Several preclinical and clinical studies have shown that drug therapy ultimately leads to a regression of the angiographic lesions but also results in a reduction in cardiovascular events. The dramatic failure of clinical trials evaluating the cholesterol ester transfer protein (CEPT) inhibitors, torcetrapib and dalcetrapib, has led to considerable doubt about the value of the current strategy to raise high-density lipoprotein cholesterol (HDL-C) as a treatment for cardiovascular disease. These clinical results, as well as animal studies, have revealed the complexity of HDL metabolism, assessing a more important role of functional quality compared to circulating quantity of HDL. As a result, HDL-based therapeutic interventions that maintain or enhance HDL functionality, such as improving its main property, the reverse cholesterol transport, require closer investigation. In this review, we will discuss HDL metabolism and function, clinical-trial data available for HDL-raising agents, and potential strategies for future HDL-based therapies. PMID:26535185

  16. Measurements of uranium mass confined in high density plasmas

    International Nuclear Information System (INIS)

    Stoeffler, R.C.

    1976-01-01

    An x-ray absorption method for measuring the amount of uranium confined in high-density, rf-heated uranium plasmas is described. Preliminary tests were conducted to calibrate the measurement system using argon, uranium hexafluoride (UF 6 ), and mixtures of argon and UF 6 at room temperature. A comparison of measured absorption of 8 keV x-rays with absorption calculated using Beer's Law indicated the method could be used to measure uranium densities from 3 x 10 16 atoms/cm 3 to 3 x 10 18 atoms/cm 3 . Tests were conducted to measure the density of uranium in an rf-heated argon plasma with UF 6 injection and with the power to maintain the discharge supplied by the United Technologies Research Center (UTRC) 1.2-MW rf induction heater facility. The uranium density was measured as the UF 6 flow rate through the test chamber was varied. A maximum uranium density of 3.85 x 10 17 atoms/cm 3 was measured

  17. Silicon micromachining using a high-density plasma source

    International Nuclear Information System (INIS)

    McAuley, S.A.; Ashraf, H.; Atabo, L.; Chambers, A.; Hall, S.; Hopkins, J.; Nicholls, G.

    2001-01-01

    Dry etching of Si is critical in satisfying the demands of the micromachining industry. The micro-electro-mechanical systems (MEMS) community requires etches capable of high aspect ratios, vertical profiles, good feature size control and etch uniformity along with high throughput to satisfy production requirements. Surface technology systems' (STS's) high-density inductively coupled plasma (ICP) etch tool enables a wide range of applications to be realized whilst optimizing the above parameters. Components manufactured from Si using an STS ICP include accelerometers and gyroscopes for military, automotive and domestic applications. STS's advanced silicon etch (ASE TM ) has also allowed the first generation of MEMS-based optical switches and attenuators to reach the marketplace. In addition, a specialized application for fabricating the next generation photolithography exposure masks has been optimized for 200 mm diameter wafers, to depths of ∼750 μm. Where the profile is not critical, etch rates of greater than 8 μm min -1 have been realized to replace previous methods such as wet etching. This is also the case for printer applications. Specialized applications that require etching down to pyrex or oxide often result in the loss of feature size control at the interface; this is an industry wide problem. STS have developed a technique to address this. The rapid progression of the industry has led to development of the STS ICP etch tool, as well as the process. (author)

  18. High-density housing that works for all

    Energy Technology Data Exchange (ETDEWEB)

    Hasan, Arif

    2010-03-15

    In an urbanising world, the way people fit into cities is vastly important - socially, economically, environmentally, even psychologically. So density, or the number of people living in a given area, is central to urban design and planning. Both governments and markets tend to get density wrong, leading to overcrowding, urban sprawl or often both. A case in point are the high-rise buildings springing up throughtout urban Asia - perceived as key features of that widely touted concept, the 'world-class city'. While some may offer a viable solution to land pressures and density requirements, many built to house evicted or resettled 'slum' dwellers are a social and economic nightmare - inconveniently sited, overcrowded and costly. New evidence from Karachi, Pakistan, reveals a real alternative. Poor people can create liveable high-density settlements as long as community control, the right technical assistance and flexible designs are in place. A city is surely 'world-class' only when it is cosmopolitan – built to serve all, including the poorest.

  19. High Density Lipoprotein: A Therapeutic Target in Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Philip J. Barter

    2013-09-01

    Full Text Available High density lipoproteins (HDLs have a number of properties that have the potential to inhibit the development of atherosclerosis and thus reduce the risk of having a cardiovascular event. These protective effects of HDLs may be reduced in patients with type 2 diabetes, a condition in which the concentration of HDL cholesterol is frequently low. In addition to their potential cardioprotective properties, HDLs also increase the uptake of glucose by skeletal muscle and stimulate the synthesis and secretion of insulin from pancreatic β cells and may thus have a beneficial effect on glycemic control. This raises the possibility that a low HDL concentration in type 2 diabetes may contribute to a worsening of diabetic control. Thus, there is a double case for targeting HDLs in patients with type 2 diabetes: to reduce cardiovascular risk and also to improve glycemic control. Approaches to raising HDL levels include lifestyle factors such as weight reduction, increased physical activity and stopping smoking. There is an ongoing search for HDL-raising drugs as agents to use in patients with type 2 diabetes in whom the HDL level remains low despite lifestyle interventions.

  20. High-Density Quantum Sensing with Dissipative First Order Transitions

    Science.gov (United States)

    Raghunandan, Meghana; Wrachtrup, Jörg; Weimer, Hendrik

    2018-04-01

    The sensing of external fields using quantum systems is a prime example of an emergent quantum technology. Generically, the sensitivity of a quantum sensor consisting of N independent particles is proportional to √{N }. However, interactions invariably occurring at high densities lead to a breakdown of the assumption of independence between the particles, posing a severe challenge for quantum sensors operating at the nanoscale. Here, we show that interactions in quantum sensors can be transformed from a nuisance into an advantage when strong interactions trigger a dissipative phase transition in an open quantum system. We demonstrate this behavior by analyzing dissipative quantum sensors based upon nitrogen-vacancy defect centers in diamond. Using both a variational method and a numerical simulation of the master equation describing the open quantum many-body system, we establish the existence of a dissipative first order transition that can be used for quantum sensing. We investigate the properties of this phase transition for two- and three-dimensional setups, demonstrating that the transition can be observed using current experimental technology. Finally, we show that quantum sensors based on dissipative phase transitions are particularly robust against imperfections such as disorder or decoherence, with the sensitivity of the sensor not being limited by the T2 coherence time of the device. Our results can readily be applied to other applications in quantum sensing and quantum metrology where interactions are currently a limiting factor.

  1. Corrosion of high-density sintered tungsten alloys. Part 3

    International Nuclear Information System (INIS)

    Batten, J.J.; Bombaci, S.A.; Garrard, W.N.C.; Moore, B.T.; Smith, B.S.

    1988-12-01

    The corrosion behaviour of tungsten and high-density tungsten alloys (W ≥ 90 weight %) has been examined electrochemically through anodic polarization measurements, instantaneous corrosion rate measurements, galvanic coupling, and surface potential mapping. In the anodic polarization tests, pure tungsten and the four alloys studied underwent transitions from an active state to a state where any further increase in potential produced no further increase in current. The presence of chloride ions increased corrosion rates. Predictions of likely trends in corrosion rates from the above electrochemical tests were not in complete agreement with those obtained by the long-term immersion tests. Similarly, a consistent prediction of the likely nature of the corrosion products that would result from long-term immersion testing was not obtained from the above studies. Predictions about which alloys would be susceptible to a crevice effect were in agreement with the immersion testing results, namely those alloys not containing Cu would be the most susceptible. Some insight into the nature of the corrosion mechanism is afforded by the work on galvanic coupling and surface potential mapping. This supported the view that galvanic corrosion plays a part in the corrosion process. 15 refs., 5 tabs., 19 figs

  2. High density scalp EEG in frontal lobe epilepsy.

    Science.gov (United States)

    Feyissa, Anteneh M; Britton, Jeffrey W; Van Gompel, Jamie; Lagerlund, Terrance L; So, Elson; Wong-Kisiel, Lilly C; Cascino, Gregory C; Brinkman, Benjamin H; Nelson, Cindy L; Watson, Robert; Worrell, Gregory A

    2017-01-01

    Localization of seizures in frontal lobe epilepsy using the 10-20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG). We performed a retrospective cohort study of 14 consecutive patients who underwent hdEEG monitoring for suspected frontal lobe seizures. The gold standard for localization was considered to be iEEG. Concordance of hdEEG findings with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional 10-20 EEG, and iEEG as well as correlation of hdEEG localization with surgical outcome were examined. hdEEG localization was concordant with iEEG in 12/14 and was superior to conventional EEG 3/14 (pfrontal epilepsy requiring localization of epileptogenic brain. hdEEG may assist in developing a hypothesis for iEEG monitoring and could potentially augment EEG source localization. Published by Elsevier B.V.

  3. The physics of the high density Z-pinch

    International Nuclear Information System (INIS)

    Glasser, A.H.; Hammel, J.E.; Lewis, H.R.

    1988-01-01

    The fiber-initiated High-Density Z-Pinch (HDZP) is a novel concept in which fusion plasma could be produced by applying 2 MV along a thin filament of frozen deuterium, 20-30 μm in diameter, 5-10 cm long. The megamp-range currents that result would ohmically heat the fiber to fusion temperatures in 100 ns while maintaining nearly constant radius. The plasma pressure would be held stably by the self-magnetic field for many radial sound transit times during the current-rise phase while, in the case of D-T, a significant fraction of the fiber undergoes thermonuclear fusion. This paper presents results of Los Alamos HDZP studies. Existing and new experiments are described. A succession of theoretical studies, including 1D self-similar and numerical studies of the hot plasma phase, 1D and 2D numerical studies of the cold startup phase, and 3D numerical studies of stability in the hot regime, are then presented. 9 refs., 4 figs

  4. High-density matter: current status and future challenges

    Directory of Open Access Journals (Sweden)

    Stone J. R.

    2015-01-01

    Full Text Available There are many fascinating processes in the Universe which we observe in more and more in detail thanks to increasingly sophisticated technology. One of the most interesting phenomena is the life cycle of stars, their birth, evolution and death. If the stars are massive enough, they end their lives in the core-collapse supernova explosion, the one of the most violent events in the Universe. As the result, the densest objects in the Universe, neutron stars and/or black holes are created. Naturally, the physical basis of these events should be understood in line with observation. The current status of our knowledge of processes in the life of stars is far from adequate for their true understanding. We show that although many models have been constructed their detailed ability to describe observations is limited or non-existent. Furthermore the general failure of all models means that we cannot tell which are heading in the right direction. A possible way forward in modeling of high-density matter is outlined, exemplified by the quark-meson-coupling model (QMC. This model has a natural explanation for the saturation of nuclear forces and depends on very few adjustable parameters, strongly constrained by the underlying physics. Latest QMC results for compact objects and finite nuclei are presented.

  5. Performance of ultra-high-density microelectrode arrays

    Energy Technology Data Exchange (ETDEWEB)

    Gunning, D.E. [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)]. E-mail: d.gunning@physics.gla.ac.uk; Chichilnisky, E.J. [Salk Institute for Biological Studies, La Jolla, CA 92037 6099 (United States); Litke, A.M. [Santa Cruz Institute forParticle Physics, Santa Cruz, CA 95064 (United States); O' Shea, V. [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Smith, K.M. [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Mathieson, K. [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)

    2007-06-11

    Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneously from hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of {approx}200 k{omega} at 1 kHz and the RMS noise of the whole recording system is 7 {mu}V with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z=300 k{omega} iridium oxide interface capable of delivering large currents Q {sub cap}=4 mC/cm{sup 2} to cells was also developed.

  6. High-Density Superconducting Cables for Advanced ACTPol

    Science.gov (United States)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Niraula, P.; Salatino, M.; Schillaci, A.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.

    2016-07-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measurement of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 \\upmu m pitch superconducting flexible cables (flex) to connect the detector wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered aluminum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97 %.

  7. Irradiation testing of high-density uranium alloy dispersion fuels

    International Nuclear Information System (INIS)

    Hayes, S.L.; Trybus, C.L.; Meyer, M.K.

    1997-01-01

    Two irradiation test vehicles have been designed, fabricated, and inserted into the Advanced Test Reactor in Idaho. Irradiation of these experiments began in August 1997. These irradiation tests were designed to obtain irradiation performance information on a variety of potential new, high-density dispersion fuels. Each of the two irradiation vehicles contains 32 'microplates'. Each microplate is aluminum clad, having an aluminum matrix phase and containing one of the following compositions as the fuel phase: U-10Mo, U-8Mo, U-6Mo, U-4Mo, U-9Nb-3Zr, U-6Nb-4Zr, U-5Nb-3Zr, U-6Mo-1Pt, U-6Mo-0.6Ru, U10Mo-0.05Sn, U2Mo, or U 3 Si 2 . These experiments will be discharged at peak fuel burnups of approximately 40 and 80 at.% U 235 . Of particular interest are the extent of reaction of the fuel and matrix phases and the fission gas retention/swelling characteristics of these new fuel alloys. This paper presents the design of the irradiation vehicles and the irradiation conditions. (author)

  8. LTCC magnetic components for high density power converter

    Science.gov (United States)

    Lebourgeois, Richard; Labouré, Eric; Lembeye, Yves; Ferrieux, Jean-Paul

    2018-04-01

    This paper deals with multilayer magnetic components for power electronics application and specifically for high frequency switching. New formulations based on nickel-zinc-copper spinel ferrites were developed for high power and high frequency applications. These ferrites can be sintered at low temperature (around 900°C) which makes them compatible with the LTCC (Low Temperature Co-fired Ceramics) technology. Metallic parts of silver or gold can be fully integrated inside the ferrite while guaranteeing the integrity of both the ferrite and the metal. To make inductors or transformers with the required properties, it is mandatory to have nonmagnetic parts between the turns of the winding. Then it is essential to find a dielectric material, which can be co-sintered both with the ferrite and the metal. We will present the solution we found to this problem and we will describe the results we obtained for a multilayer co-sintered transformer. We will see that these new components have good performance compared with the state of the art and are very promising for developing high density switching mode power supplies.

  9. Using NEG-pumping near a high density internal target

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, Alexander; Marton, Johann; Widmann, Eberhard; Zmeskal, Johann [Stefan Meyer Institut fuer Subatomare Physik, OeAW (Germany); Orth, Herbert [GSI, Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany)

    2009-07-01

    The universal detector PANDA will be constructed at the future high-energy antiproton storage ring HESR at FAIR (Facility for Antiproton and Ion Research, GSI/Darmstadt). It will use antiproton beams (1.5 to 15 GeV/c) for hadron physics in the charmonium region. The Stefan Meyer Institut (SMI) contributes to major parts of the PANDA detector like the hydrogen cluster-jet target and the vacuum system of the antiproton - target interaction zone. To ensure low background, the residual gas load in the interaction zone and in the antiproton beam-pipe has to be minimised. Most of the gas load will come from the high density internal hydrogen target. As the detector will cover almost the full solid angle, the installation of pumps near the interaction zone is impossible. Therefore the use of NEG (non-evaporative-getter) coated beam pipes has been considered as an alternative. Two setups with NEG coated tubes have been installed at SMI as prototypes of the PANDA interaction zone. General parameters of the NEG-film, its outgassing behaviour, the pumping speed and the pumping capacity for hydrogen have been tested. The results of the studies on the PANDA-interaction region are presented.

  10. High-density polyethylene dosimetry by transvinylene FTIR analysis

    DEFF Research Database (Denmark)

    McLaughlin, W.L.; Silverman, J.; Al-Sheikhly, M.

    1999-01-01

    and electrons. The useful dose range of 0.053 cm thick high-density polyethylene film (rho = 0.961 g cm(-3); melt index = 0.8 dg min(-1)), for irradiations by (60)Co gamma radiation and 2.0 and 0.4 MeV electron beams in deaerated atmosphere (Na gas), is about 50-10(3) kGy for FTIR transvinylene......The formation of transvinylene unsaturation, -CH=CH-, due to free-radical or cationic-initiated dehydrogenation by irradiation, is a basic reaction in polyethylene and is useful for dosimetry at high absorbed doses. The radiation-enhanced infrared absorption having a maximum at nu = 965 cm......(-l) (lambda = 10.36 mu m) is stable in air and can be measured by Fourier-transform infrared (FTIR) spectrophotometry. The quantitative analysis is a useful means of product end-point dosimetry for radiation processing with gamma rays and electrons, where polyethylene is a component of the processed product...

  11. Properties of recycled high density polyethylene and coffee dregs composites

    Directory of Open Access Journals (Sweden)

    Sibele Piedade Cestari

    2013-01-01

    Full Text Available Composites of recycled high density polyethylene (HDPE-R and coffee dregs (COFD were elaborated. The blends were made at the proportions of 100-0, 90-10, 80-20, 70-30, 60-40, 50-50 and 40-60% polymer-filler ratio. The materials were evaluated through scanning electron microscopy (SEM, differential scanning calorimetry (DSC, thermogravimetry/derivative thermogravimetry (TGA, and compressive resistance test. The compounding was done using a two-stage co-kneader system extruder, and then cylindrical specimens were injection molded. All composites had a fine dispersion of the COFD into the polymeric matrix. The composites degraded in two steps. The first one was in a temperature lower than the neat HDPE, but higher than the average processing temperature of the polymer. The melting temperature and the degree of crystallinity of the composites resulted similar to the neat HDPE ones. The compressive moduli of the composites resulted similar to the neat polymer one. The results show that these composites have interesting properties as a building material.

  12. Performance of ultra-high-density microelectrode arrays

    Science.gov (United States)

    Gunning, D. E.; Chichilnisky, E. J.; Litke, A. M.; O'Shea, V.; Smith, K. M.; Mathieson, K.

    2007-06-01

    Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneously from hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of ˜200 kΩ at 1 kHz and the RMS noise of the whole recording system is 7 μV with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z=300 kΩ iridium oxide interface capable of delivering large currents Qcap=4 mC/cm 2 to cells was also developed.

  13. High-Density Infrared Surface Treatments of Refractories

    Energy Technology Data Exchange (ETDEWEB)

    Tiegs, T.N.

    2005-03-31

    Refractory materials play a crucial role in all energy-intensive industries and are truly a crosscutting technology for the Industries of the Future (IOF). One of the major mechanisms for the degradation of refractories and a general decrease in their performance has been the penetration and corrosion by molten metals or glass. Methods and materials that would reduce the penetration, wetting, and corrosive chemistry would significantly improve refractory performance and also maintain the quality of the processed liquid, be it metal or glass. This report presents the results of an R&D project aimed at investigating the use of high-density infrared (HDI) heating to surface treat refractories to improve their performance. The project was a joint effort between Oak Ridge National Laboratory (ORNL) and the University of Missouri-Rolla (UMR). HDI is capable of heating the near-surface region of materials to very high temperatures where sintering, diffusion, and melting can occur. The intended benefits of HDI processing of refractories were to (1) reduce surface porosity (by essentially sealing the surface to prevent liquid penetration), (2) allow surface chemistry changes to be performed by bonding an adherent coating onto the underlying refractory (in order to inhibit wetting and/or improve corrosion resistance), and (3) produce noncontact refractories with high-emissivity surface coatings.

  14. Acrolein impairs the cholesterol transport functions of high density lipoproteins.

    Science.gov (United States)

    Chadwick, Alexandra C; Holme, Rebecca L; Chen, Yiliang; Thomas, Michael J; Sorci-Thomas, Mary G; Silverstein, Roy L; Pritchard, Kirkwood A; Sahoo, Daisy

    2015-01-01

    High density lipoproteins (HDL) are considered athero-protective, primarily due to their role in reverse cholesterol transport, where they transport cholesterol from peripheral tissues to the liver for excretion. The current study was designed to determine the impact of HDL modification by acrolein, a highly reactive aldehyde found in high abundance in cigarette smoke, on the cholesterol transport functions of HDL. HDL was chemically-modified with acrolein and immunoblot and mass spectrometry analyses confirmed apolipoprotein crosslinking, as well as acrolein adducts on apolipoproteins A-I and A-II. The ability of acrolein-modified HDL (acro-HDL) to serve as an acceptor of free cholesterol (FC) from COS-7 cells transiently expressing SR-BI was significantly decreased. Further, in contrast to native HDL, acro-HDL promotes higher neutral lipid accumulation in murine macrophages as judged by Oil Red O staining. The ability of acro-HDL to mediate efficient selective uptake of HDL-cholesteryl esters (CE) into SR-BI-expressing cells was reduced compared to native HDL. Together, the findings from our studies suggest that acrolein modification of HDL produces a dysfunctional particle that may ultimately promote atherogenesis by impairing functions that are critical in the reverse cholesterol transport pathway.

  15. Olive oil phenolic compounds and high-density lipoprotein function.

    Science.gov (United States)

    Hernáez, Alvaro; Farràs, Marta; Fitó, Montserrat

    2016-02-01

    The functional capacities of high-density lipoproteins (HDLs) reflect the physiological role of the particle better than the quantity of HDL cholesterol. Owing to its phenolic compounds, the consumption of virgin olive oil has emerged as a promising therapy to promote these capacities. This review highlights the human studies that explain these benefits and explores some possible mechanisms. The consumption of olive oil phenolic compounds increased the ability of HDLs to pick up cholesterol excess in peripheral cells (the cholesterol efflux capacity). Olive oil phenolic compounds have also been shown to improve HDL antioxidant capacities and some anti-inflammatory traits. These changes respond to an improvement of HDL oxidative status and composition. Novel strategies to increase HDL functional capacities are in demand from clinicians. The attainment of a fully-functional HDL through dietary or lifestyle changes is a priority in cardiovascular research. Within this context, the consumption of virgin olive oil, because of its phenolic compounds, may be a relevant protective approach. Further studies in large-scale, randomized controlled trials are, however, required to confirm these effects in HDL functionality.

  16. High-Density Stretchable Electrode Grids for Chronic Neural Recording.

    Science.gov (United States)

    Tybrandt, Klas; Khodagholy, Dion; Dielacher, Bernd; Stauffer, Flurin; Renz, Aline F; Buzsáki, György; Vörös, János

    2018-02-28

    Electrical interfacing with neural tissue is key to advancing diagnosis and therapies for neurological disorders, as well as providing detailed information about neural signals. A challenge for creating long-term stable interfaces between electronics and neural tissue is the huge mechanical mismatch between the systems. So far, materials and fabrication processes have restricted the development of soft electrode grids able to combine high performance, long-term stability, and high electrode density, aspects all essential for neural interfacing. Here, this challenge is addressed by developing a soft, high-density, stretchable electrode grid based on an inert, high-performance composite material comprising gold-coated titanium dioxide nanowires embedded in a silicone matrix. The developed grid can resolve high spatiotemporal neural signals from the surface of the cortex in freely moving rats with stable neural recording quality and preserved electrode signal coherence during 3 months of implantation. Due to its flexible and stretchable nature, it is possible to minimize the size of the craniotomy required for placement, further reducing the level of invasiveness. The material and device technology presented herein have potential for a wide range of emerging biomedical applications. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Inelastic neutron scattering from high-density fcc 4He

    International Nuclear Information System (INIS)

    Thomlinson, W.; Eckert, J.; Shirane, G.

    1978-01-01

    The phonon dispersion relations in high-density crystals of fcc 4 He have been measured along high-symmetry directions by the neutron-inelastic-scattering technique. A recent study of the lattice dynamics of fcc 4 He by Eckert et al. has been extended to cover the fcc phase diagram at pressures below 5 kbar. Molar volumes of 9.03, 9.43, and 9.97 cm 3 /mole have been studied in the temperature range from near the melting curve to near the fcc-hcp transition line. The phonon dispersion relations are in good agreement with a first-order self-consistent phonon theory calculation by Goldman. The observed phonon-group line shapes at large energy and momentum transfers show evidence for multiphonon scattering in agreement with calculations by Glyde. Eckert et al. reported extremely large anharmonic isochoric temperature shifts of the phonon energies. The present work studied the shifts as a function of molar volume and temperature. Mode-Grueneisen-parameter dispersion curves have been measured using the present data and earlier measurements at lower density in the fcc phase by Traylor et al. Macroscopic Grueneisen parameters have been calculated from the phonon density of states obtained from the data

  18. High-Density Otologic Camps in Regions of Sparse Expertise.

    Science.gov (United States)

    Girma, Bizuayehu; Bitew, Asnake; Kiros, Nega; Redleaf, Miriam

    2018-03-01

    Aims/Purpose: When 2 models of otologic surgery instruction in Ethiopia are compared, high-density otologic surgery campaigns are more effective for accelerated skills transfer in areas of sparse expertise than the standard outpatient clinic/OR model. A continuously operating otolaryngology/head and neck surgery department in a large public hospital is compared with a nonprofit specialty hospital where outpatients are selected for weeklong surgical campaigns. The number and variety of otologic visits and operations in each setting, presence of expert supervision, and resident-trainees' surgical progress were tallied. The public hospital saw 84 otologic operations in 1 full year. Meanwhile, the ear specialty surgical campaign site saw 185 otologic operations in 6 surgical campaign weeks. All operations at both sites were performed primarily by trainees. Experienced otologists supervised 40% of operations at the public hospital and 100% at the surgical campaign site. At the end of the year, none of the 10 resident-trainees in the public hospital were able to perform a simple underlay tympanoplasty, compared to 6 of 12 resident-trainees in the campaign setting. Where otologic expertise is sparse, otologic surgical campaigns allow the most effective use of resources-patient pathology, medical facilities, trainee attendance, and imported instructors.

  19. Using NEG-pumping near a high density internal target

    International Nuclear Information System (INIS)

    Gruber, A.; Marton, J.; Widmann, E.; Zmeskal, J.; Orth, H.

    2008-01-01

    Full text: The Stefan Meyer Institut (SMI) is part of the international PANDA collaboration. The universal detector will be constructed at the future high-energy antiproton storage ring HESR at FAIR (Facility for Antiproton and Ion Research, GSI/Darmstadt). PANDA will use antiproton beams (1.5 to 15 GeV/c) for hadron physics in the charmonium region. SMI contributes to major parts of the PANDA detector like the hydrogen cluster-jet target and the vacuum system of the antiproton - target interaction zone. To ensure low background, the residual gas load in the interaction zone and in the antiproton beam-pipe has to be minimized. Most of the gas load, of course will come from the high density internal hydrogen target. Since the PANDA detector will cover almost the full solid angle, the installation of pumps near the interaction zone is impossible. Therefore, the use of NEG (non-evaporative-getter) coated beam pipes has been considered as an alternative. Two setups with NEG coated tubes have been installed at SMI as prototypes of the PANDA interaction zone. The outgassing behavior, the pumping speed and the pumping capacity for hydrogen have been tested. The status of the studies of the interaction region will be presented. (author)

  20. Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics

    NARCIS (Netherlands)

    Kim, Yongtae; Fay, Francois; Cormode, David P.; Sanchez-Gaytan, Brenda L.; Tang, Jun; Hennessy, Elizabeth J.; Ma, Mingming; Moore, Kathryn; Farokhzad, Omid C.; Fisher, Edward Allen; Mulder, Willem J. M.; Langer, Robert; Fayad, Zahi A.

    2013-01-01

    High-density lipoprotein (HDL) is a natural nanoparticle that transports peripheral cholesterol to the liver. Reconstituted high-density lipoprotein (rHDL) exhibits antiatherothrombotic properties and is being considered as a natural treatment for cardiovascular diseases. Furthermore, HDL

  1. Surface interactions involved in flashover with high density electronegative gases.

    Energy Technology Data Exchange (ETDEWEB)

    Hodge, Keith Conquest; Warne, Larry Kevin; Jorgenson, Roy Eberhardt; Wallace, Zachariah Red; Lehr, Jane Marie

    2010-01-01

    This report examines the interactions involved with flashover along a surface in high density electronegative gases. The focus is on fast ionization processes rather than the later time ionic drift or thermalization of the discharge. A kinetic simulation of the gas and surface is used to examine electron multiplication and includes gas collision, excitation and ionization, and attachment processes, gas photoionization and surface photoemission processes, as well as surface attachment. These rates are then used in a 1.5D fluid ionization wave (streamer) model to study streamer propagation with and without the surface in air and in SF6. The 1.5D model therefore includes rates for all these processes. To get a better estimate for the behavior of the radius we have studied radial expansion of the streamer in air and in SF6. The focus of the modeling is on voltage and field level changes (with and without a surface) rather than secondary effects, such as, velocities or changes in discharge path. An experiment has been set up to carry out measurements of threshold voltages, streamer velocities, and other discharge characteristics. This setup includes both electrical and photographic diagnostics (streak and framing cameras). We have observed little change in critical field levels (where avalanche multiplication sets in) in the gas alone versus with the surface. Comparisons between model calculations and experimental measurements are in agreement with this. We have examined streamer sustaining fields (field which maintains ionization wave propagation) in the gas and on the surface. Agreement of the gas levels with available literature is good and agreement between experiment and calculation is good also. Model calculations do not indicate much difference between the gas alone versus the surface levels. Experiments have identified differences in velocity between streamers on the surface and in the gas alone (the surface values being larger).

  2. Degradation of high density lipoprotein in cultured rat luteal cells

    International Nuclear Information System (INIS)

    Rajan, V.P.; Menon, K.M.J.

    1986-01-01

    In rat ovary luteal cells, degradation of high density lipoprotein (HDL) to tricholoracetic acid (TCA)-soluble products accounts for only a fraction of the HDL-derived cholesterol used for steroidogenesis. In this study the authors have investigated the fate of 125 I]HDL bound to cultured luteal cells using pulse-chase technique. Luteal cell cultures were pulse labeled with [ 125 I]HDL 3 and reincubated in the absence of HDL. By 24 h about 50% of the initallay bound radioactivity was released into the medium, of which 60-65% could be precipitated with 10% TCA. Gel filtration of the chase incubation medium on 10% agarose showed that the amount of TCA-soluble radioactivity was nearly completely accounted for by a sharp peak in the low molecular weight region which was identified as 96% monoiodotyrosine by paper chromatography. The TCA-precipitable radioactivity was nearly completely accounted for by a sharp peak in the low molecular weight region which was identified as 96% monoiodotyrosine by paper chromatography. The TCA-precipitable radioactivity eluted over a wide range of molecular weights (15,000-80,000), and there was very little intact HDL present. Electrophoresis of the chase medium showed that component of the TCA-precipitable portion had mobility similar to apo AI. Lysosomal inhibitors of receptor-mediated endocytosis had no effect on the composition or quantity of radioactivity released during chase incubation. The results show that HDL 3 binding to luteal cells is followed by complete degradation of the lipoprotein, although the TCA-soluble part does not reflect the extent of degradation

  3. Modelling high density phenomena in hydrogen fibre Z-pinches

    International Nuclear Information System (INIS)

    Chittenden, J.P.

    1990-09-01

    The application of hydrogen fibre Z-pinches to the study of the radiative collapse phenomenon is studied computationally. Two areas of difficulty, the formation of a fully ionized pinch from a cryogenic fibre and the processes leading to collapse termination, are addressed in detail. A zero-D model based on the energy equation highlights the importance of particle end losses and changes in the Coulomb logarithm upon collapse initiation and termination. A 1-D Lagrangian resistive MHD code shows the importance of the changing radial profile shapes, particularly in delaying collapse termination. A 1-D, three fluid MHD code is developed to model the ionization of the fibre by thermal conduction from a high temperature surface corona to the cold core. Rate equations for collisional ionization, 3-body recombination and equilibration are solved in tandem with fluid equations for the electrons, ions and neutrals. Continuum lowering is found to assist ionization at the corona-core interface. The high density plasma phenomena responsible for radiative collapse termination are identified as the self-trapping of radiation and free electron degeneracy. A radiation transport model and computational analogues for the effects of degeneracy upon the equation of state, transport coefficients and opacity are implemented in the 1-D, single fluid model. As opacity increases the emergent spectrum is observed to become increasingly Planckian and a fall off in radiative cooling at small radii and low frequencies occurs giving rise to collapse termination. Electron degeneracy terminates radiative collapse by supplementing the radial pressure gradient until the electromagnetic pinch force is balanced. Collapse termination is found to be a hybrid process of opacity and degeneracy effects across a wide range of line densities with opacity dominant at large line densities but with electron degeneracy becoming increasingly important at lower line densities. (author)

  4. FROM SLOW FOOD TO SLOW TOURISM

    Directory of Open Access Journals (Sweden)

    Bac Dorin Paul

    2014-12-01

    Full Text Available One of the effects of globalization is the faster pace of our lives. This rhythm can be noticed in all aspects of life: travel, work, shopping, etc. and it has serious negative effects. It has become common knowledge that stress and speed generate serious medical issues. Food and eating habits in the modern world have taken their toll on our health. However, some people took a stand and argued for a new kind of lifestyle. It all started in the field of gastronomy, where a new movement emerged – Slow Food, based on the ideas and philosophy of Carlo Petrini. Slow Food represents an important adversary to the concept of fast food, and is promoting local products, enjoyable meals and healthy food. The philosophy of the Slow Food movement developed in several directions: Cittaslow, slow travel and tourism, slow religion and slow money etc. The present paper will account the evolution of the concept and its development during the most recent years. We will present how the philosophy of slow food was applied in all the other fields it reached and some critical points of view. Also we will focus on the presence of the slow movement in Romania, although it is in a very early stage of development. The main objectives of the present paper are: to present the chronological and ideological evolution of the slow movement; to establish a clear separation of slow travel and slow tourism, as many mistake on for the other; to review the presence of the slow movement in Romania. Regarding the research methodology, information was gathered from relevant academic papers and books and also from interviews and discussions with local entrepreneurs. The research is mostly theoretical and empirical, as slow food and slow tourism are emerging research themes in academic circles.

  5. Biofuels Barrier Properties of Polyamide 6 and High Density Polyethylene

    Directory of Open Access Journals (Sweden)

    Fillot L.-A.

    2015-02-01

    Full Text Available In this paper, a comparison of the biofuels barrier properties of PolyAmide 6 (PA6 and High Density PolyEthylene (HDPE is presented. Model fuels were prepared as mixtures of toluene, isooctane and ethanol, the ethanol volume fraction varying between 0% and 100%. Barrier properties were determined at 40°C by gravimetric techniques or gas chromatography measurements, and it was shown that polyamide 6 permeability is lower than that of polyethylene on a wide range of ethanol contents up to 85% of ethanol (E85 in the biofuel, permeability of PA6 being 100 times lower than that of HDPE for low ethanol content fuels (E5, E0. The time-lags were also compared, and on the whole range of ethanol contents, HDPE permeation kinetics appears to be much faster than that of PA6, the time lag for a 1 mm thick specimens in presence of E10 being 50 days for PA6 and 0.5 days for HDPE. The compositions of the solvent fluxes were analyzed by FID gas chromatography, and it turned out that the solvent flux was mainly made up of ethanol (minimum 95% in the case of PA6, whereas in the case of HDPE, solvent flux was mainly made up of hydrocarbons. The implication of this difference in the solvent flux composition is discussed in the present article, and a side effect called the “fuel exhaustion process” is presented. The influence of the sample thickness was then studied, and for the different biofuels compositions, the pervaporation kinetics of polyamide 6 appeared to evolve with the square of the thickness, a long transitory regime being highlighted in the case of PA6. This result implies that the time needed to characterize the steady state permeability of thick PA6 parts such as fuel tanks can be very long (one year or more, this duration being far superior to the Euros 5 or Euro 6 standard emission measurements time scale. The influence of temperature on the permeability was finally assessed, and the activation energy that is the signature of the temperature

  6. Human endothelial progenitor cells internalize high-density lipoprotein.

    Directory of Open Access Journals (Sweden)

    Kaemisa Srisen

    Full Text Available Endothelial progenitor cells (EPCs originate either directly from hematopoietic stem cells or from a subpopulation of monocytes. Controversial views about intracellular lipid traffic prompted us to analyze the uptake of human high density lipoprotein (HDL, and HDL-cholesterol in human monocytic EPCs. Fluorescence and electron microscopy were used to investigate distribution and intracellular trafficking of HDL and its associated cholesterol using fluorescent surrogates (bodipy-cholesterol and bodipy-cholesteryl oleate, cytochemical labels and fluorochromes including horseradish peroxidase and Alexa Fluor® 568. Uptake and intracellular transport of HDL were demonstrated after internalization periods from 0.5 to 4 hours. In case of HDL-Alexa Fluor® 568, bodipy-cholesterol and bodipy-cholesteryl oleate, a photooxidation method was carried out. HDL-specific reaction products were present in invaginations of the plasma membrane at each time of treatment within endocytic vesicles, in multivesicular bodies and at longer periods of uptake, also in lysosomes. Some HDL-positive endosomes were arranged in form of "strings of pearl"- like structures. HDL-positive multivesicular bodies exhibited intensive staining of limiting and vesicular membranes. Multivesicular bodies of HDL-Alexa Fluor® 568-treated EPCs showed multilamellar intra-vacuolar membranes. At all periods of treatment, labeled endocytic vesicles and organelles were apparent close to the cell surface and in perinuclear areas around the Golgi apparatus. No HDL-related particles could be demonstrated close to its cisterns. Electron tomographic reconstructions showed an accumulation of HDL-containing endosomes close to the trans-Golgi-network. HDL-derived bodipy-cholesterol was localized in endosomal vesicles, multivesicular bodies, lysosomes and in many of the stacked Golgi cisternae and the trans-Golgi-network Internalized HDL-derived bodipy-cholesteryl oleate was channeled into the lysosomal

  7. High density plasma heating in the Tokamak à configuration variable

    International Nuclear Information System (INIS)

    Curchod, L.

    2011-04-01

    The Tokamak à Configuration Variable (TCV) is a medium size magnetic confinement thermonuclear fusion experiment designed for the study of the plasma performances as a function of its shape. It is equipped with a high power and highly flexible electron cyclotron heating (ECH) and current drive (ECCD) system. Up to 3 MW of 2 nd harmonic EC power in ordinary (O 2 ) or extraordinary (X 2 ) polarization can be injected from TCV low-field side via six independently steerable launchers. In addition, up to 1.5 MW of 3 rd harmonic EC power (X 3 ) can be launched along the EC resonance from the top of TCV vacuum vessel. At high density, standard ECH and ECCD are prevented by the appearance of a cutoff layer screening the access to the EC resonance at the plasma center. As a consequence, less than 50% of TCV density operational domain is accessible to X 2 and X 3 ECH. The electron Bernstein waves (EBW) have been proposed to overcome this limitation. EBW is an electrostatic mode propagating beyond the plasma cutoff without upper density limit. Since it cannot propagate in vacuum, it has to be excited by mode conversion of EC waves in the plasma. Efficient electron Bernstein waves heating (EBH) and current drive (EBCD) were previously performed in several fusion devices, in particular in the W7-AS stellarator and in the MAST spherical tokamak. In TCV, the conditions for an efficient O-X-B mode conversion (i.e. a steep density gradient at the O 2 plasma cutoff) are met at the edge of high confinement (H-mode) plasmas characterized by the appearance of a pedestal in the electron temperature and density profiles. TCV experiments have demonstrated the first EBW coupling to overdense plasmas in a medium aspect-ratio tokamak via O-X-B mode conversion. This thesis work focuses on several aspects of ECH and EBH in low and high density plasmas. Firstly, the experimental optimum angles for the O-X-B mode conversion is successfully compared to the full-wave mode conversion calculation

  8. Strongly interacting matter at high densities with a soliton model

    Science.gov (United States)

    Johnson, Charles Webster

    1998-12-01

    One of the major goals of modern nuclear physics is to explore the phase diagram of strongly interacting matter. The study of these 'extreme' conditions is the primary motivation for the construction of the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory which will accelerate nuclei to a center of mass (c.m.) energy of about 200 GeV/nucleon. From a theoretical perspective, a test of quantum chromodynamics (QCD) requires the expansion of the conditions examined from one phase point to the entire phase diagram of strongly-interacting matter. In the present work we focus attention on what happens when the density is increased, at low excitation energies. Experimental results from the Brookhaven Alternating Gradient Synchrotron (AGS) indicate that this regime may be tested in the 'full stopping' (maximum energy deposition) scenario achieved at the AGS having a c.m. collision energy of about 2.5 GeV/nucleon for two equal- mass heavy nuclei. Since the solution of QCD on nuclear length-scales is computationally prohibitive even on today's most powerful computers, progress in the theoretical description of high densities has come through the application of models incorporating some of the essential features of the full theory. The simplest such model is the MIT bag model. We use a significantly more sophisticated model, a nonlocal confining soliton model developed in part at Kent. This model has proven its value in the calculation of the properties of individual mesons and nucleons. In the present application, the many-soliton problem is addressed with the same model. We describe nuclear matter as a lattice of solitons and apply the Wigner-Seitz approximation to the lattice. This means that we consider spherical cells with one soliton centered in each, corresponding to the average properties of the lattice. The average density is then varied by changing the size of the Wigner-Seitz cell. To arrive at a solution, we need to solve a coupled set of

  9. Towards high-density matter with relativistic heavy-ion collisions

    International Nuclear Information System (INIS)

    Nagamiya, Shoji.

    1990-04-01

    Recent progress in nucleus-nucleus collisions at BNL and CERN suggests a hint that the formation of high-density nuclear matter could be possible with relativistic heavy-ion beams. What is the maximum density that can be achieved by heavy-ion collisions? Are there data which show evidence or hints on the formation of high density matter? Why is the research of high-density interesting? How about the future possibilities on this subject? These points are discussed. (author)

  10. Compensated readout for high-density MOS-gated memristor crossbar array

    KAUST Repository

    Zidan, Mohammed A.

    2015-01-01

    Leakage current is one of the main challenges facing high-density MOS-gated memristor arrays. In this study, we show that leakage current ruins the memory readout process for high-density arrays, and analyze the tradeoff between the array density and its power consumption. We propose a novel readout technique and its underlying circuitry, which is able to compensate for the transistor leakage-current effect in the high-density gated memristor array.

  11. High Channel Count, High Density Microphone Arrays for Wind Tunnel Environments, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Interdisciplinary Consulting Corporation (IC2) proposes the development of high channel count, high density, reduced cost per channel, directional microphone...

  12. Scalp and Source Power Topography in Sleepwalking and Sleep Terrors: A High-Density EEG Study.

    Science.gov (United States)

    Castelnovo, Anna; Riedner, Brady A; Smith, Richard F; Tononi, Giulio; Boly, Melanie; Benca, Ruth M

    2016-10-01

    To examine scalp and source power topography in sleep arousals disorders (SADs) using high-density EEG (hdEEG). Fifteen adult subjects with sleep arousal disorders (SADs) and 15 age- and gender-matched good sleeping healthy controls were recorded in a sleep laboratory setting using a 256 channel EEG system. Scalp EEG analysis of all night NREM sleep revealed a localized decrease in slow wave activity (SWA) power (1-4 Hz) over centro-parietal regions relative to the rest of the brain in SADs compared to good sleeping healthy controls. Source modelling analysis of 5-minute segments taken from N3 during the first half of the night revealed that the local decrease in SWA power was prominent at the level of the cingulate, motor, and sensori-motor associative cortices. Similar patterns were also evident during REM sleep and wake. These differences in local sleep were present in the absence of any detectable clinical or electrophysiological sign of arousal. Overall, results suggest the presence of local sleep differences in the brain of SADs patients during nights without clinical episodes. The persistence of similar topographical changes in local EEG power during REM sleep and wakefulness points to trait-like functional changes that cross the boundaries of NREM sleep. The regions identified by source imaging are consistent with the current neurophysiological understanding of SADs as a disorder caused by local arousals in motor and cingulate cortices. Persistent localized changes in neuronal excitability may predispose affected subjects to clinical episodes. © 2016 Associated Professional Sleep Societies, LLC.

  13. The role of group index engineering in series-connected photonic crystal microcavities for high density sensor microarrays

    International Nuclear Information System (INIS)

    Zou, Yi; Zhu, Liang; Chen, Ray T.; Chakravarty, Swapnajit

    2014-01-01

    We experimentally demonstrate an efficient and robust method for series connection of photonic crystal microcavities that are coupled to photonic crystal waveguides in the slow light transmission regime. We demonstrate that group index taper engineering provides excellent optical impedance matching between the input and output strip waveguides and the photonic crystal waveguide, a nearly flat transmission over the entire guided mode spectrum and clear multi-resonance peaks corresponding to individual microcavities that are connected in series. Series connected photonic crystal microcavities are further multiplexed in parallel using cascaded multimode interference power splitters to generate a high density silicon nanophotonic microarray comprising 64 photonic crystal microcavity sensors, all of which are interrogated simultaneously at the same instant of time

  14. Improvements in gastric diagnosis by using high density contrast media with low viscosity

    International Nuclear Information System (INIS)

    Toischer, H.P.

    1983-01-01

    In a retrospective clinical study, 150 unselected double contrast examinations of the stomach using conventional contrast media (100 g/100 ml barium sulphate) were compared with a similar number of examinations using a high density contrast medium of flow viscosity (250 g/100 ml barium sulphate). The high density contrast medium was distinctly better for demonstrating detail of the gastric mucosa. The uneveness of coating and instability of the older high density contrast media was observed in 15.5% of cases and, in no instance, did this make it impossible to reach a diagnosis. (orig.) [de

  15. High-density lipoproteins and adrenal steroidogenesis : A population-based study

    NARCIS (Netherlands)

    Buitenwerf, Edward; Kerstens, Michiel N.; Links, Thera P.; Kema, Ido P.; Dullaart, Robin P. F.

    BACKGROUND: Cholesterol trafficked within plasma lipoproteins, in particular high-density lipoproteins (HDL), may represent an important source of cholesterol that is required for adrenal steroidogenesis. Based on a urinary gas chromatography method, compromised adrenal function has been suggested

  16. 128x128 Ultra-High Density Optical Interconnect, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Future NASA programs like Tertiary Planet Finder (TPF) require high-density deformable mirrors with up to 16,000 actuators to enable direct imaging of planets around...

  17. A Decentralized Control Strategy for High Density Material Flow Systems with Automated Guided Vehicles

    OpenAIRE

    Schwab, Melanie

    2015-01-01

    This work presents a universal decentralized control strategy for grid-based high-density material flow systems with automated guided vehicles and gives insights into the system behavior as well as the solution quality.

  18. Assessing the functional properties of high-density lipoproteins : an emerging concept in cardiovascular research

    NARCIS (Netherlands)

    Triolo, Michela; Annema, Wijtske; Dullaart, Robin P. F.; Tietge, Uwe J. F.

    Although plasma concentrations of high-density lipoprotein (HDL) cholesterol correlate inversely with the incidence of atherosclerotic cardiovascular disease, results from recent epidemiological, genetic and pharmacological intervention studies resulted in a shift of concept. Rather than HDL

  19. Moderate doses of alcoholic beverages with dinner and postprandial high density lipoprotein composition

    NARCIS (Netherlands)

    Hendriks, H.F.J.; Veenstra, J.; Tol, A. van; Groener, J.E.M.; Schaafsma, G.

    1998-01-01

    Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. In this study, postprandial changes in plasma lipids, high-density lipoprotein (HDL) composition and cholesteryl ester transfer protein (CETP) and lecithin: cholesterol acyltransferase (LCAT) activity levels

  20. ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels

    NARCIS (Netherlands)

    Trigueros-Motos, Laia; van Capelleveen, Julian C.; Torta, Federico; Castaño, David; Zhang, Lin-Hua; Chai, Ee Chu; Kang, Martin; Dimova, Lidiya G.; Schimmel, Alinda W. M.; Tietjen, Ian; Radomski, Chris; Tan, Liang Juin; Thiam, Chung Hwee; Narayanaswamy, Pradeep; Wu, Daniel Heqing; Dorninger, Fabian; Yakala, Gopala Krishna; Barhdadi, Amina; Angeli, Veronique; Dubé, Marie-Pierre; Berger, Johannes; Dallinga-Thie, Geesje M.; Tietge, Uwe J. F.; Wenk, Markus R.; Hayden, Michael R.; Hovingh, G. Kees; Singaraja, Roshni R.

    2017-01-01

    Objective-High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues. However, factors regulating lipid efflux are incompletely understood. We previously identified a variant in adenosine

  1. High-density polymer microarrays: identifying synthetic polymers that control human embryonic stem cell growth.

    Science.gov (United States)

    Hansen, Anne; Mjoseng, Heidi K; Zhang, Rong; Kalloudis, Michail; Koutsos, Vasileios; de Sousa, Paul A; Bradley, Mark

    2014-06-01

    The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Clinical significance of diminution of high-density areas in basal cisterns following acute aneurysmal bleeding

    International Nuclear Information System (INIS)

    Matsuzaki, Takayuki; Takeda, Rihei; Nakagawara, Jyoji; Sato, Shigeru; Fujiwara, Hidetoshi

    1983-01-01

    We analyzed the sequential changes in the high density in basal cisterns in the acute stage of aneurysmal bleeding. We could recognize Group 3 (clot or thick layer), according to Fisher's classification, in 66.3% of the intracranial aneurysms at admission (83 cases). In the early stage of an intracranial aneurysm, a subarachnoid hemorrhage (SAH) was detected in all the patients on CT. We evaluated 40 cases of Group 3 sequentially on CT. This investigation showed that 55% of the Grade I--Ii group, 27.3% of the Grade III group, and 11.1% of the Grade IV--V group changed to Group 2(thin or diffuse pattern) in approximately 20 hours on the average. As for the correlation between the high density in basal cisterns and the neurological condition (Hunt and Hess), we found a neurological improvement in the decreased-high-density group. The unchanged- high-density group showed deterioration. Compared with the decreased-high-density group, the unchanged group showed a greater increase in the CVI (Cerebro Ventricular Index). RI ( 111 In) cisternography also showed a disturbance of the CSF circulation. To lower the vasospasm it is important to decrease the high density in an early stage by carrying out CSF. It was considered to be prognostic when a CT scan was performed within 24 hours after SAH. (author)

  3. The effect of water stress on super-high- density 'Koroneiki' olive oil quality.

    Science.gov (United States)

    Dag, Arnon; Naor, Amos; Ben-Gal, Alon; Harlev, Guy; Zipori, Isaac; Schneider, Doron; Birger, Reuven; Peres, Moti; Gal, Yoni; Kerem, Zohar

    2015-08-15

    Over the last two decades, the area of cultivated super-high-density olive orchards has increased rapidly. Water stress is an important tool in super-high-density orchards to reduce tree growth and promote suitability for overhead mechanical harvesters. Little is known regarding the effect of water stress in super-high-density orchards on oil quality parameters. In this study the effect of irrigation rate on oil quality parameters was evaluated in a six-year-old super-high-density 'Koreneiki' olive orchard for five consecutive seasons. Five water status levels, determined by irrigating in order to maintain various midday stem water potential threshold values (-1.5, -2, -2.5, -3 and -4 MPa), were applied during the oil accumulation stage. The MUFA/PUFA ratio and free fatty acid content generally decreased as a function of increasing tree water stress. In most seasons a reduction in polyphenols was found with decreasing irrigation level. Peroxide value was not affected by the water stress level. The present study demonstrates that limiting irrigation and exposure of olive trees to water stress in a super-high-density orchard lowers free fatty acid content and therefore benefits oil quality. However, the decreased MUFA/PUFA ratio and the reduction in polyphenol content that were also found under increased water stress negatively influence oil quality. © 2014 Society of Chemical Industry.

  4. High density intercalation of porphyrin into transparent clay membrane without aggregation.

    Science.gov (United States)

    Fujimura, Takuya; Shimada, Tetsuya; Hamatani, Satoshi; Onodera, Shingo; Sasai, Ryo; Inoue, Haruo; Takagi, Shinsuke

    2013-04-23

    Cationic porphyrin was successfully intercalated into transparent clay membrane by developing the new strategy for the sample preparation conditions. When water:ethanol = 1:2 (v:v) was used as solvent for porphyrin penetration process, high density intercalation of porphyrin into the clay membrane was achieved. In the interlayer space, porphyrin molecules do not aggregate owing to intercharge distance matching effect (size-matching effect), even at high density condition. Judging from XRD and absorption measurements, the orientations of the porphyrins in the clay layers should be almost parallel to the clay nanosheet as monolayer. Because the fluorescence quantum yield did not depend on its loading level, it is turned out that intercalated TMPyP in the clay film keeps the photoactivity even under the high density conditions.

  5. The final stage of gravitational collapse for high density fluid medium

    Energy Technology Data Exchange (ETDEWEB)

    Souza, R. G. [Physics Department , Roraima Federal University, 69304-000 Boa Vista, RR (Brazil); De Campos, M. [Physics Department, Roraima Federal University, 69304-000 Boa Vista, RR (Brazil) and Astronomy Department, Sao Paulo University, 05508-900 Sao Paulo, SP (Brazil)

    2013-03-25

    The High density high density fluids can be represented by a stiff matter state equation P={rho} and also by the Hagedorn state equation. The first is constructed using a lagrangian that allows bare nucleons to interact attractively via scalar meson exchange, and repulsively by a more massive vector meson exchange; the second consider that for large mass the spectrum of hadrons grows exponentially, namely {rho}(m) {approx}exp(m/T{sub H}), where T{sub H} is the Hagedorn temperature, resulting the state equation P = P{sub 0}+{rho}{sub 0}ln({rho}/{rho}{sub 0}). We study the gravitational collapse for a high density fluid, considering a Hagedorn state equation in a presence of a vacuum component.

  6. A power-driven increment borer for sampling high-density tropical wood

    OpenAIRE

    Stefan Krottenthaler; Philipp Pitsch; G. Helle; Giuliano Maselli Locosselli; Gregório Ceccantini; Jan Altman; Miroslav Svoboda; Jiri Dolezal; Gerhard Schleser; Dieter Anhuf

    2015-01-01

    High-density hardwood trees with large diameters have been found to damage manually operated increment borers, thus limiting their use in the tropics. Therefore, we herein report a new, low-cost gasoline-powered sampling system for high-density tropical hardwood trees with large diameters. This system provides increment cores 15 mm in diameter and up to 1.35 m in length, allowing minimally invasive sampling of tropical hardwood tree species, which, up to the present, could not be collected by...

  7. Remarks on the demands for the qualification of high density fuel

    International Nuclear Information System (INIS)

    Krull, W.

    1984-01-01

    Research reactors using today highly enriched uranium (HEU) will be obliged within the next years to use low enriched uranium (LEU). The qualification of this fuel is a major task researches are doing world-wide. As qualification can be a relative statement the demands on the qualification of high density fuel from the standpoint of a research reactor operator are given. The needed qualification steps are described: test of miniplates, test fuel elements and whole core conversion. The different demands on the qualified fuel from the fuel fabricator, the licensing procedure and the reactor operator are discussed. Finally the status of qualification for high density fuel is summarized. (orig.) [de

  8. High-Density Chemical Intercalation of Zero-Valent Copper into Bi 2 Se 3 Nanoribbons

    KAUST Repository

    Koski, Kristie J.

    2012-05-09

    A major goal of intercalation chemistry is to intercalate high densities of guest species without disrupting the host lattice. Many intercalant concentrations, however, are limited by the charge of the guest species. Here we have developed a general solution-based chemical method for intercalating extraordinarily high densities of zero-valent copper metal into layered Bi 2Se 3 nanoribbons. Up to 60 atom % copper (Cu 7.5Bi 2Se 3) can be intercalated with no disruption to the host lattice using a solution disproportionation redox reaction. © 2012 American Chemical Society.

  9. LTE Micro-cell Deployment for High-Density Railway Areas

    DEFF Research Database (Denmark)

    Sniady, Aleksander; Kassab, Mohamed; Soler, José

    2014-01-01

    Long Term Evolution (LTE) is a serious candidate for the future releases of the European Rail Traffic Management System (ERTMS). LTE offers more capacity and supports new communication-based applications and services for railways. Nevertheless, even with this technology, the classical macro......-cell radio deployments reach overload, especially in high-density areas, such as major train stations. In this paper, an LTE micro-cell deployment is investigated in high-density railway areas. Copenhagen Main Station is considered as a realistic deployment study case, with a set of relevant railway...

  10. Interplay between spin polarization and color superconductivity in high density quark matter

    DEFF Research Database (Denmark)

    Tsue, Yasuhiko; da Providência, João; Providência, Constança

    2013-01-01

    Here, it is suggested that a four-point interaction of the tensor type may lead to spin polarization in quark matter at high density. It is found that the two-flavor superconducting phase and the spin polarized phase correspond to distinct local minima of a certain generalized thermodynamical...... potential. It follows that a transition from one to the other phase occurs, passing through true minima with both a spin polarization and a color superconducting gap. It is shown that the quark spin polarized phase is realized at rather high density, while the two-flavor color superconducting phase...

  11. Turbulence at the transition to the high density H-mode in Wendelstein 7-AS plasmas

    DEFF Research Database (Denmark)

    Basse, N.P.; Zoletnik, S.; Baumel, S.

    2003-01-01

    Recently a new improved confinement regime was found in the Wendelstein 7-AS (W7-AS) stellarator (Renner H. et al 1989 Plasma Phys. Control. Fusion 31 1579). The discovery of this high density high confinement mode (HDH-mode) was facilitated by the installation of divertor modules. In this paper,...

  12. Improving the circular economy via hydrothermal processing of high-density waste plastics

    DEFF Research Database (Denmark)

    Pedersen, Thomas Helmer; Conti, Federica

    2017-01-01

    Rising environmental concerns on climate changes are causing an increasing attention on circular economies. The plastic economy, in particular, is in focus due to the accelerating consumption of plastics, mainly derived from virgin feedstock, combined with the lack of plastic recycling strategies...... processing of high-density plastics is a prospective technology for increasing the circularity of the plastic economy....

  13. Residual gas entering high density hydrogen plasma: rarefaction due to rapid heating

    NARCIS (Netherlands)

    N. den Harder,; D.C. Schram,; W. J. Goedheer,; de Blank, H. J.; M. C. M. van de Sanden,; van Rooij, G. J.

    2015-01-01

    The interaction of background molecular hydrogen with magnetized (0.4 T) high density (1–5 × 10 20  m −3 ) low temperature (∼3 eV) hydrogen plasma was inferred from the Fulcher band emission in the linear plasma generator Pilot-PSI. In the plasma center,

  14. Collision frequency of Lennard–Jones fluids at high densities by ...

    Indian Academy of Sciences (India)

    Abstract. Detailed classical molecular dynamics simulation of transport coefficients and collision frequencies at high densities in rare gases are presented in this paper with a view to investigate the likely cause of discrepancy between theory and experiments. The results, when compared with experiments, showed an ...

  15. Collision frequency of Lennard–Jones fluids at high densities by ...

    Indian Academy of Sciences (India)

    Detailed classical molecular dynamics simulation of transport coefficients and collision frequencies at high densities in rare gases are presented in this paper with a view to investigate the likely cause of discrepancy between theory and experiments. The results, when compared with experiments, showed an ...

  16. Self-consistency condition and high-density virial theorem in relativistic many-particle systems

    International Nuclear Information System (INIS)

    Kalman, G.; Canuto, V.; Datta, B.

    1976-01-01

    In order for the thermodynamic and kinetic definitions of the chemical potential and the pressure to lead to identical results a nontrivial self-consistency criterion has to be satisfied. This, in turn, leads to a virial-like theorem in the high-density limit

  17. Assessing the feasibility of high-density subsurface heat extraction in urban areas

    Science.gov (United States)

    Abesser, Corinna; Busby, Jonathan

    2017-04-01

    The subsurface is increasingly utilized as a heat source (sink) for use in heating (and cooling) applications. This is driven by the need to increase the amount of heat generated from renewable sources to meet the EU renewable energy target of 12% by 2020. This study explores the feasibility, performance and long-term sustainability of high density, closed-loop GSHP installations in urban areas. Specifically, it employs a 2D, finite element, heat transport model to assess the impact of high density heat extraction in a residential area in Reading. A block of semi-detached houses is modelled, assuming that separate GSHP systems are installed in every property. The model considers conductive and advective heat transport. Uncertainties are explored through varying thermal properties and groundwater gradients across the site. Different heat demand scenarios are evaluated and the impact on the subsurface temperature distribution and on heat pump efficiency is assessed. The scenarios are selected to represent variations in inter-annual weather pattern, heating pattern and building insulation standards. Results indicate that high density heat extraction for domestic heating can be sustainable over the lifespan expected for GSHP systems (of around 20 years), in particular where heat demand is reduced by home improvement measures. Based on the results, recommendations are being presented for the sustainable deployment of high density GSHP installation in urban areas.

  18. Properties Of 10 Ghanaian High Density Lesser-Used-Species Of ...

    African Journals Online (AJOL)

    Properties Of 10 Ghanaian High Density Lesser-Used-Species Of Importance To Bridge Construction – Part 2: Mechanical Strength Properties. ... The range of mean strength values in N/mm2 in the 'green' [and dry] conditions for the ten wood species were as follows: - Modulus of Rupture: 69-132 [104-188], Modulus of ...

  19. Relations between coordinate and potential scaling in the high-density limit

    Science.gov (United States)

    Whittingham, Takeyce K.; Burke, Kieron

    2005-04-01

    Exact relations are derived between scaling to the high-density limit of density functional theory and taking Z to infinity for nondegenerate atoms. Görling-Levy perturbation results are deduced for hydrogenic densities. The kinetic contribution to the correlation energy is also studied, and estimates given for its value for neutral atoms. Popular approximate functionals are tested against these benchmarks.

  20. High density nuclear Mach shock waves in relativistic nucleus-nucleus collisions

    International Nuclear Information System (INIS)

    Stocker, H.; Hofmann, J.; Scheid, W.; Greiner, W.

    1976-01-01

    The occurrence of high density nuclear Mach shock waves in relativistic nucleus-nucleus collisions and related phenomena, as density isomers, highly isobaric and hot nuclear matter, pionization and granulation of dense matter, compressibility and soundwaves in nuclear matter, are discussed

  1. Case of thalamic hemorrhage presenting high density on CT in a long time

    Energy Technology Data Exchange (ETDEWEB)

    Hosoya, Takaaki; Takeda, Yoshio; Sugai, Yukio; Umetsu, Akemi; Yamaguchi, Koichi

    1988-05-01

    We presented a thalamic hemorrhage in a 29-year-old woman with idiopathic thrombocytopenic purpura during pregnancy showing a high density lesion at least for 50 days on CT. From beginning of the illness, this condition was considered to continue for 3 months by chronic bleeding or recurrent hemorrhage.

  2. Usefulness of multi-plane dynamic subtraction CT (MPDS-CT) for intracranial high density lesions

    International Nuclear Information System (INIS)

    Takagi, Ryo; Kumazaki, Tatsuo

    1996-01-01

    We present a new CT technique using the high speed CT scanner in detection and evaluation of temporal and spatial contrast enhancement of intracranial high density lesions. A multi-plane dynamic subtraction CT (MPDS-CT) was performed in 21 patients with intracranial high density lesions. These lesions consisted of 10 brain tumors, 7 intracerebral hemorrhages and 4 vascular malformations (2 untreated, 2 post-embolization). Baseline study was first performed, and 5 sequential planes of covering total high density lesions were selected. After obtaining the 5 sequential CT images as mask images, three series of multi-plane dynamic CT were performed for the same 5 planes with an intravenous bolus injection of contrast medium. MPDS-CT images were reconstructed by subtracting dynamic CT images from the mask ones. MPDS-CT were compared with conventional contrast-enhanced CT. MPDS-CT images showed the definite contrast enhancement of high density brain tumors and vascular malformations which were not clearly identified on conventional contrast-enhanced CT images because of calcified or hemorrhagic lesions and embolic materials, enabling us to eliminate enhanced abnormalities with non-enhanced areas such as unusual intracerebral hemorrhages. MPDS-CT will provide us further accurate and objective information and will be greatly helpful for interpreting pathophysiologic condition. (author)

  3. The constraints of high density production of the calanoid copepod Acartia tonsa Dana

    DEFF Research Database (Denmark)

    Vu, Minh T. T.; Hansen, Benni W.; Kiørboe, Thomas

    2017-01-01

    studied and aquaculture relevant calanoid Acartia tonsa. A simple model was developed to evaluate the influence of individual egg production, egg predation, crowding effects and tank design on the egg harvest. At high densities from 500 to 3500 ind L−1, there was no difference in food ingestion and egg...

  4. Plasma modification of sisal and high-density polyethylene composites : effect on mechanical properties

    Science.gov (United States)

    A.R. Martin; S. Manolache; L.H.C. Mattoso; R.M. Rowell; F. Denes

    2000-01-01

    Sisal fibers and finely powdered high-density polyethylene were surface functionalized using dichlorosilane (DS) under R-F plasma conditions to improve interfacial adhesion between the two dissimilar substrates. The functionalized polyethylene (70%) and sisal (30%) were compounded on four different ways using thermokinetic mixer and injected molded into composites...

  5. A proposal of nitrogen balance in a very high density olive orchard ...

    African Journals Online (AJOL)

    The nitrogen (N) balance was estimated in a very high density olive orchard in north- east of Spain, in order to calculate the inputs and outputs of N related to tree response and soil nitrogen availability. The calculate N inputs and outputs showed that N exported by yield and pruning material were higher for fertilized plots ...

  6. Effect of resin variables on the creep behavior of high density hardwood composite panels

    Science.gov (United States)

    R.C. Tang; Jianhua Pu; C.Y Hse

    1993-01-01

    The flexural creep behavior of oriented strandboards (OSB) fabricated with mixed high, density hardwood flakes was investigated. Three types of adhesives, liquid phenolic-formaldehyde (LPF), melamine modified urea-formaldehyde (MUF), and LPF (face)/MUF (core) were chosen in this investigation. The resin contents (RC) used were 3.5 percent and 5.0 percent. The flakes...

  7. THE GRAFTING OF MALEIC-ANHYDRIDE ON HIGH-DENSITY POLYETHYLENE IN AN EXTRUDER

    NARCIS (Netherlands)

    GANZEVELD, KJ; JANSSEN, LPBM

    The grafting of maleic anhydride (MAH) on high density polyethylene in a counter-rotating twin screw extruder has been studied. As the reaction kinetics appear to be affected by mass transfer, good micro mixing in the extruder is important. Due to the competing mechanisms of increasing mixing and

  8. Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings.

    Science.gov (United States)

    Peng, Yun; He, Jinbao; Khavari, Rose; Boone, Timothy B; Zhang, Yingchun

    2016-11-01

    Knowledge of the innervation of pelvic floor and sphincter muscles is of great importance to understanding the pathophysiology of female pelvic floor dysfunctions. This report presents our high-density intravaginal and intrarectal electromyography (EMG) probes and a comprehensive innervation zone (IZ) imaging technique based on high-density EMG readings to characterize the IZ distribution. Both intravaginal and intrarectal probes are covered with a high-density surface electromyography electrode grid (8 × 8). Surface EMG signals were acquired in ten healthy women performing maximum voluntary contractions of their pelvic floor. EMG decomposition was performed to separate motor-unit action potentials (MUAPs) and then localize their IZs. High-density surface EMG signals were successfully acquired over the vaginal and rectal surfaces. The propagation patterns of muscle activity were clearly visualized for multiple muscle groups of the pelvic floor and anal sphincter. During each contraction, up to 218 and 456 repetitions of motor units were detected by the vaginal and rectal probes, respectively. MUAPs were separated with their IZs identified at various orientations and depths. The proposed probes are capable of providing a comprehensive mapping of IZs of the pelvic floor and sphincter muscles. They can be employed as diagnostic and preventative tools in clinical practices.

  9. Evaluation of pyrus and quince rootstocks for high density pear orchards

    NARCIS (Netherlands)

    Maas, F.M.

    2008-01-01

    High density planting systems are a prerequisite to economise the use of land and labour costs of orchards. Dwarfing rootstocks controlling the vigour of the scion cultivars form the basis for such orchards (Wertheim and Webster, 2005). In the Netherlands, rootstock research is limited to and

  10. The (Anomalous) Hall Magnetometer as an Analysis Tool for High Density Recording Media

    NARCIS (Netherlands)

    de Haan, S.; de Haan, S.; Lodder, J.C.; Popma, T.J.A.

    1991-01-01

    In this work an evaluation tool for the characterization of high-density recording thin film media is discussed. The measurement principles are based on the anomalous and the planar Hall effect. We used these Hall effects to characterize ferromagnetic Co-Cr films and Co/Pd multilayers having

  11. Los Alamos compact toroid, fast-liner, and high-density Z-pinch programs

    Energy Technology Data Exchange (ETDEWEB)

    Linford, R.K.; Sherwood, A.R.; Hammel, J.E.

    1981-03-01

    The Compact Toroid (CT) and High Density Z-Pinch (HDZP) are two of the plasma configurations presently being studied at Los Alamos. The purpose of these two programs, plus the recently terminated (May 1979) Fast Liner (FL) program, is summarized in this section along with a brief description of the experimental facilities. The remaining sections summarize the recent results and the experimental status.

  12. Magnetic force microscopy of thin film media for high density magnetic recording

    NARCIS (Netherlands)

    Porthun, Steffen; Porthun, S.; Abelmann, Leon; Lodder, J.C.

    1998-01-01

    This paper discusses various aspect of magnetic force microscopy (MFM) for use in the field of high density magnetic recording. After an introduction of the most important magnetic imaging techniques, an overview is given of the operation and theory of MFM. The developments in instrumentation, MFM

  13. Analysis of the weld strength of the High Density Polyethylene (HDPE)

    African Journals Online (AJOL)

    An analysis was carried out to determine the strength of welded joints in High Density Polyethylene (HDPE) dam liners. Samples were collected of welded joints and subjected to tensile tests and creep test. It was observed that the welded joints from field welded samples were much weaker and had a very low straining ...

  14. Increased Antioxidant Quality Versus Lower Quantity Of High Density Lipoprotein In Benign Prostatic Hyperplasia

    Directory of Open Access Journals (Sweden)

    Aydin Ozgur

    2015-10-01

    Full Text Available Background: Oxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH, we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL-related antioxidant enzymes paraoxonase 1 (PON1 and arylesterase (ARE.

  15. Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol

    DEFF Research Database (Denmark)

    Feitosa, Mary F; Wojczynski, Mary K; Straka, Robert

    2014-01-01

    The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease (CVD), and have also been associated with longevity. We sought to identify novel loci for HDL that could potentially provide new insights...

  16. Properties of high density polyethylene – Paulownia wood flour composites via injection molding

    Science.gov (United States)

    Paulownia wood (PW) flour is evaluated as a bio-based fiber reinforcement. Composites of high density polyethylene (HDPE), 25% by weight of PW, and either 0% or 5% by weight of maleated polyethylene (MAPE) were produced by twin screw compounding followed by injection molding. Molded test composite...

  17. Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation

    NARCIS (Netherlands)

    Yuana, Yuana; Levels, Johannes; Grootemaat, Anita; Sturk, Auguste; Nieuwland, Rienk

    2014-01-01

    Extracellular vesicles (EVs) facilitate intercellular communication by carrying bioactive molecules such as proteins, messenger RNA, and micro (mi)RNAs. Recently, high-density lipoproteins (HDL) isolated from human plasma were also reported to transport miRNA to other cells. HDL, when isolated from

  18. Radiation Tests of Highly scaled, High-Density, Commercial, Nonvolatile NAND Flash Memories--Update 2011

    Science.gov (United States)

    Irom, Farokh; Nguyen, Duc N.

    2011-01-01

    High-density, commercial, nonvolatile flash memories with NAND architecture are now available from several manufacturers. This report examines SEE effects and TID response in single-level cell (SLC) 32Gb and multi-level cell (MLC) 64Gb NAND flash memories manufactured by Micron Technology.

  19. Radiation Tests of Highly Scaled, High-Density, Commercial, Nonvolatile NAND Flash Memories - Update 2010

    Science.gov (United States)

    Irom, Farokh; Nguyen, Duc N.

    2010-01-01

    High-density, commercial, nonvolatile flash memories with NAND architecture are now available from several manufacturers. This report examines SEE effects and TID response in single-level cell (SLC) and multi-level cell (MLC) NAND flash memories manufactured by Micron Technology.

  20. The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?

    NARCIS (Netherlands)

    Vergeer, Menno; Holleboom, Adriaan G.; Kastelein, John J. P.; Kuivenhoven, Jan Albert

    2010-01-01

    There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for

  1. Effect of weathering variables on the lightness of high-density polyethylene woodflour composites

    Science.gov (United States)

    Nicole M. Stark

    2005-01-01

    Wood-plastic lumber is promoted as a low-maintenance, high-durability product. After weathering, however, wood-plastic composites (WPCs) often fade. In the first part of this study, 50 percent woodflour-filled high- density polyethylene (HDPE) composite samples were manufactured. Composites were exposed to two accelerated weathering cycles in a xenon- arc type...

  2. Transcriptomic Profiling of High-Density Giardia Foci Encysting in the Murine Proximal Intestine.

    Science.gov (United States)

    Pham, Jonathan K; Nosala, Christopher; Scott, Erica Y; Nguyen, Kristofer F; Hagen, Kari D; Starcevich, Hannah N; Dawson, Scott C

    2017-01-01

    Giardia is a highly prevalent, understudied protistan parasite causing significant diarrheal disease worldwide. Its life cycle consists of two stages: infectious cysts ingested from contaminated food or water sources, and motile trophozoites that colonize and attach to the gut epithelium, later encysting to form new cysts that are excreted into the environment. Current understanding of parasite physiology in the host is largely inferred from transcriptomic studies using Giardia grown axenically or in co-culture with mammalian cell lines. The dearth of information about the diversity of host-parasite interactions occurring within distinct regions of the gastrointestinal tract has been exacerbated by a lack of methods to directly and non-invasively interrogate disease progression and parasite physiology in live animal hosts. By visualizing Giardia infections in the mouse gastrointestinal tract using bioluminescent imaging (BLI) of tagged parasites, we recently showed that parasites colonize the gut in high-density foci. Encystation is initiated in these foci throughout the entire course of infection, yet how the physiology of parasites within high-density foci in the host gut differs from that of cells in laboratory culture is unclear. Here we use BLI to precisely select parasite samples from high-density foci in the proximal intestine to interrogate in vivo Giardia gene expression in the host. Relative to axenic culture, we noted significantly higher expression (>10-fold) of oxidative stress, membrane transporter, and metabolic and structural genes associated with encystation in the high-density foci. These differences in gene expression within parasite foci in the host may reflect physiological changes associated with high-density growth in localized regions of the gut. We also identified and verified six novel cyst-specific proteins, including new components of the cyst wall that were highly expressed in these foci. Our in vivo transcriptome data support an

  3. SPS slow extraction septa

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    SPS long straight section (LSS) with a series of 5 septum tanks for slow extraction (view in the direction of the proton beam). There are 2 of these: in LSS2, towards the N-Area; in LSS6 towards the W-Area. See also Annual Report 1975, p.175.

  4. High-Density Physical Random Number Generator Using Spin Signals in Multidomain Ferromagnetic Layer

    Directory of Open Access Journals (Sweden)

    Sungwoo Chun

    2015-01-01

    Full Text Available A high-density random number generator (RNG based on spin signals in a multidomain ferromagnetic layer in a magnetic tunnel junction (MTJ is proposed and fabricated. Unlike conventional spin-based RNGs, the proposed method does not require one to control an applied current, leading to a time delay in the system. RNG demonstrations are performed at room temperature. The randomness of the bit sequences generated by the proposed RNG is verified using the FIPS 140-2 statistical test suite provided by the NIST. The test results validate the effectiveness of the proposed RNGs. Our results suggest that we can obtain high-density, ultrafast RNGs if we can achieve high integration on the chip.

  5. OSCAR experiment high-density network data report: Event 3 - April 16-17, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Dana, M.T.; Easter, R.C.; Thorp, J.M.

    1984-12-01

    The OSCAR (Oxidation and Scavenging Characteristics of April Rains) experiment, conducted during April 1981, was a cooperative field investigation of wet removal in cyclonic storm systems. The high-density component of OSCAR was located in northeast Indiana and included sequential precipitation chemistry measurements on a 100 by 100 km network, as well as airborne air chemistry and cloud chemistry measurements, surface air chemistry measurements, and supporting meteorological measurements. Four separate storm events were studied during the experiment. This report summarizes data taken by Pacific Northwest Laboratory (PNL) during the third storm event, April 16-17. The report contains the high-density network precipitation chemistry data, air chemistry and cloud chemistry data from the PNL aircraft, and meteorological data for the event, including standard National Weather Service products and radar and rawindsonde data from the network. 4 references, 76 figures, 6 tables.

  6. OSCAR experiment high-density network data report: Event 4 - April 21-23, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Dana, M.T.; Easter, R.C.; Thorp, J.M.

    1984-12-01

    The OSCAR (Oxidation and Scavenging Characteristics of April Rains) experiment, conducted during April 1981, was a cooperative field investigation of wet removal in cyclonic storm systems. The high-density component of OSCAR was located in northeast Indiana and included sequential precipitation chemistry measurements on a 100 by 100 km netwok, as well as airborne air chemistry and cloud chemistry mueasurements, surface air chemistry measurements, and supporting meteorological measurements. Four separate storm events were studied during the experiment. This report summarizes data taken by Pacific Northwest Laboratory (PNL) during the fourth storm event, April 21-23. The report contains the high-density network precipitation chemistry data, air and cloud chemistry data from the two PNL aircraft, and meteorological data for the event, including standard National Weather Service products and radar and rawindsonde data from the event. 3 references, 80 figures, 11 tables.

  7. Density measurements of small amounts of high-density solids by a floatation method

    International Nuclear Information System (INIS)

    Akabori, Mitsuo; Shiba, Koreyuki

    1984-09-01

    A floatation method for determining the density of small amounts of high-density solids is described. The use of a float combined with an appropriate floatation liquid allows us to measure the density of high-density substances in small amounts. Using the sample of 0.1 g in weight, the floatation liquid of 3.0 g cm -3 in density and the float of 1.5 g cm -3 in apparent density, the sample densities of 5, 10 and 20 g cm -3 are determined to an accuracy better than +-0.002, +-0.01 and +-0.05 g cm -3 , respectively that correspond to about +-1 x 10 -5 cm 3 in volume. By means of appropriate degassing treatments, the densities of (Th,U)O 2 pellets of --0.1 g in weight and --9.55 g cm -3 in density were determined with an accuracy better than +-0.05 %. (author)

  8. High-density carbon ablator ignition path with low-density gas-filled rugby hohlraum

    Science.gov (United States)

    Amendt, Peter; Ho, Darwin D.; Jones, Ogden S.

    2015-04-01

    A recent low gas-fill density (0.6 mg/cc 4He) cylindrical hohlraum experiment on the National Ignition Facility has shown high laser-coupling efficiency (>96%), reduced phenomenological laser drive corrections, and improved high-density carbon capsule implosion symmetry [Jones et al., Bull. Am. Phys. Soc. 59(15), 66 (2014)]. In this Letter, an ignition design using a large rugby-shaped hohlraum [Amendt et al., Phys. Plasmas 21, 112703 (2014)] for high energetics efficiency and symmetry control with the same low gas-fill density (0.6 mg/cc 4He) is developed as a potentially robust platform for demonstrating thermonuclear burn. The companion high-density carbon capsule for this hohlraum design is driven by an adiabat-shaped [Betti et al., Phys. Plasmas 9, 2277 (2002)] 4-shock drive profile for robust high gain (>10) 1-D ignition performance and large margin to 2-D perturbation growth.

  9. High-density carbon ablator ignition path with low-density gas-filled rugby hohlraum

    International Nuclear Information System (INIS)

    Amendt, Peter; Ho, Darwin D.; Jones, Ogden S.

    2015-01-01

    A recent low gas-fill density (0.6 mg/cc 4 He) cylindrical hohlraum experiment on the National Ignition Facility has shown high laser-coupling efficiency (>96%), reduced phenomenological laser drive corrections, and improved high-density carbon capsule implosion symmetry [Jones et al., Bull. Am. Phys. Soc. 59(15), 66 (2014)]. In this Letter, an ignition design using a large rugby-shaped hohlraum [Amendt et al., Phys. Plasmas 21, 112703 (2014)] for high energetics efficiency and symmetry control with the same low gas-fill density (0.6 mg/cc 4 He) is developed as a potentially robust platform for demonstrating thermonuclear burn. The companion high-density carbon capsule for this hohlraum design is driven by an adiabat-shaped [Betti et al., Phys. Plasmas 9, 2277 (2002)] 4-shock drive profile for robust high gain (>10) 1-D ignition performance and large margin to 2-D perturbation growth

  10. High-density carbon ablator ignition path with low-density gas-filled rugby hohlraum

    Energy Technology Data Exchange (ETDEWEB)

    Amendt, Peter; Ho, Darwin D.; Jones, Ogden S. [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States)

    2015-04-15

    A recent low gas-fill density (0.6 mg/cc {sup 4}He) cylindrical hohlraum experiment on the National Ignition Facility has shown high laser-coupling efficiency (>96%), reduced phenomenological laser drive corrections, and improved high-density carbon capsule implosion symmetry [Jones et al., Bull. Am. Phys. Soc. 59(15), 66 (2014)]. In this Letter, an ignition design using a large rugby-shaped hohlraum [Amendt et al., Phys. Plasmas 21, 112703 (2014)] for high energetics efficiency and symmetry control with the same low gas-fill density (0.6 mg/cc {sup 4}He) is developed as a potentially robust platform for demonstrating thermonuclear burn. The companion high-density carbon capsule for this hohlraum design is driven by an adiabat-shaped [Betti et al., Phys. Plasmas 9, 2277 (2002)] 4-shock drive profile for robust high gain (>10) 1-D ignition performance and large margin to 2-D perturbation growth.

  11. High-density QCD phase transitions inside neutron stars: Glitches and gravitational waves

    Science.gov (United States)

    Srivastava, A. M.; Bagchi, P.; Das, A.; Layek, B.

    2017-10-01

    We discuss physics of exotic high baryon density QCD phases which are believed to exist in the core of a neutron star. This can provide a laboratory for exploring exotic physics such as axion emission, KK graviton production etc. Much of the physics of these high-density phases is model-dependent and not very well understood, especially the densities expected to occur inside neutron stars. We follow a different approach and use primarily universal aspects of the physics of different high-density phases and associated phase transitions. We study effects of density fluctuations during transitions with and without topological defect production and study the effect on pulsar timings due to changing moment of inertia of the star. We also discuss gravitational wave production due to rapidly changing quadrupole moment of the star due to these fluctuations.

  12. Recirculating aquaculture system for high density production of the calanoid copepod Acartia tonsa (Dana)

    DEFF Research Database (Denmark)

    Vu, Minh Thi Thuy; Øie, Gunvor; Reinertsen, Helge

    2013-01-01

    The calanoid copepod Acartia tonsa (Dana) is one of the most promising copepod species for marine larviculture. This species has a wide tolerance to temperature and salinity, small size, can produce resting eggs. All their nauplii, copepodites and adults can be use as excellent feeds for marine...... fish larvae. Yet, the biomass and egg production of A. tonsa has been limited mainly due to the challanges to culture them at high density. The development of recirculating aquaculture system (RAS) in recent decades has opened a new culturing system that is expected to provide more stable environmental...... conditions to favor the production of A. tonsa at high density. The current study was initiated to preliminarily apply a recircultating aquaculture system (RAS) for A. tonsa production. A flow through aquaculture system (FTAS) was also run in parallel to evaluate the capacity of RAS compared to the FTAS...

  13. The use of high-density concretes in radiotherapy treatment room design

    International Nuclear Information System (INIS)

    Facure, A.; Silva, A.X.

    2007-01-01

    With the modernization of radiotherapic centers, medical linear accelerators are largely replacing 60 Co teletherapy units. In many cases, the same vault housing the 60 Co teletherapy unit is reused for the linear accelerator and, when space is at a premium, high-density concrete (3.0-5.0 g/cm 3 ) is employed to provide shielding against the primary, scatter and leakage radiation. This work presents a study based on Monte Carlo simulations of transmission of some clinical photon spectra (of 4-10 MV accelerators) through some types of high-density concretes, normally used in the construction of radiotherapy bunkers. From the simulations, the initial and subsequent tenth-value layers (TVL) for these materials, taking into account realistic clinical photon spectra, are presented, for primary radiation

  14. High density lipoproteins as indicators of endothelial dysfunction in children with diadetes type I

    Directory of Open Access Journals (Sweden)

    Lobanova S.M.

    2011-12-01

    Full Text Available The aim of the investigation was to study the level of blood high density lipoproteins (HDL in the groups of children with different course of diadetes type I in order to find out the dependence of course and complications of diabetes on that level. Materials and methods: Blood high density lipoprotein (HDL levels were investigated in children and adolescents with diadetes type I, depending on the duration of diadetes type I, age, stage of sexual development, the stage of diabetic nephropathy and levels of plasma endothelin-1 (E-1. Results: Decrease in HDL level with increasing duration of diadetes type I in prepubertate patients, higher indices of HDL cholesterol were determined in girls, especially with impaired puberty. HDL cholesterol was higher in diabetic nephropathy at the stage of proteinuria and high level of blood endothelin-1. Conclusion: The revealed changes were considered to cause deregulation of vascular endothelium as a manifestation of the initial stages of endothelial dysfunction

  15. The use of high-density concretes in radiotherapy treatment room design.

    Science.gov (United States)

    Facure, A; Silva, A X

    2007-09-01

    With the modernization of radiotherapic centers, medical linear accelerators are largely replacing (60)Co teletherapy units. In many cases, the same vault housing the (60)Co teletherapy unit is reused for the linear accelerator and, when space is at a premium, high-density concrete (3.0-5.0 g/cm(3)) is employed to provide shielding against the primary, scatter and leakage radiation. This work presents a study based on Monte Carlo simulations of transmission of some clinical photon spectra (of 4-10 MV accelerators) through some types of high-density concretes, normally used in the construction of radiotherapy bunkers. From the simulations, the initial and subsequent tenth-value layers (TVL) for these materials, taking into account realistic clinical photon spectra, are presented, for primary radiation.

  16. Spin polarization in high density quark matter under a strong external magnetic field

    DEFF Research Database (Denmark)

    Tsue, Yasuhiko; Da Providência, João; Providência, Constança

    2016-01-01

    In high density quark matter under a strong external magnetic field, possible phases are investigated by using the two-flavor Nambu-Jona-Lasinio (NJL) model with tensor-type four-point interaction between quarks, as well as the axial-vector-type four-point interaction. In the tensor-type interact......In high density quark matter under a strong external magnetic field, possible phases are investigated by using the two-flavor Nambu-Jona-Lasinio (NJL) model with tensor-type four-point interaction between quarks, as well as the axial-vector-type four-point interaction. In the tensor...... phase appears in the wide range of the quark chemical potential. In both the interactions, the quark mass in zero and small chemical potential regions increases which indicates that the chiral symmetry breaking is enhanced, namely the magnetic catalysis occurs....

  17. Thermal Experimental Analysis for Dielectric Characterization of High Density Polyethylene Nanocomposites

    Directory of Open Access Journals (Sweden)

    Ahmed Thabet Mohamed

    2016-01-01

    Full Text Available The importance of nanoparticles in controlling physical properties of polymeric nanocomposite materials leads us to study effects of these nanoparticles on electric and dielectric properties of polymers in industry In this research, the dielectric behaviour of High-Density Polyethylene (HDPE nanocomposites materials that filled with nanoparticles of clay or fumed silica has been investigated at various frequencies (10 Hz-1 kHz and temperatures (20-60°C. Dielectric spectroscopy has been used to characterize ionic conduction, then, the effects of nanoparticles concentration on the dielectric losses and capacitive charge of the new nanocomposites can be stated. Capacitive charge and loss tangent in high density polyethylene nanocomposites are measured by dielectric spectroscopy. Different dielectric behaviour has been observed depending on type and concentration of nanoparticles under variant thermal conditions.

  18. ChemicalVia: a CERN-patented technology for use in high-density circuits

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    High-density multilayer printed circuits such as those pictured here are found in miniaturized modern equipment from video cameras to mobile phones. Adjacent layers in these circuits are electrically connected by microvias, consisting of a small-diameter hole (usually 50 µm) with a thin metal-deposited surface covering their cylindrical walls to ensure local conductivity between the two layers. ChemicalVia is a new method, patented by CERN, to make microvias on high-density multilayer printed circuits using chemicals rather than complex laser, plasma or photoimaging technology. The process is compatible with all standard printed-circuit assembly lines, and has the advantages of low initial investment and reduced manufacturing costs. http://www.cern.ch/ttdatabase

  19. A complete life cycle assessment of high density polyethylene plastic bottle

    Science.gov (United States)

    Treenate, P.; Limphitakphong, N.; Chavalparit, O.

    2017-07-01

    This study was aimed to determine environmental performances of a lubricant oil bottle made from high density polyethylene and to develop potential measures for reducing its impacts. A complete life cycle assessment was carried out to understand a whole effect on the environment from acquiring, processing, using, and disposing the product. Two scenarios of disposal phase; recycle and incineration: were examined to quantify a lesser degree on environmental impact. The results illustrated that major impacts of the two scenarios were at the same categories with the highest contributor of raw material acquisition and pre-processing. However, all impacts in case of recycling provided a lower point than that in case of incineration, except mineral extraction. Finally, feasible measures for reducing the environmental impact of high density polyethylene plastic bottle were proposed in accordance with 3Rs concept.

  20. High-density 3D graphene-based monolith and related materials, methods, and devices

    Energy Technology Data Exchange (ETDEWEB)

    Worsley, Marcus A.; Baumann, Theodore F.; Biener, Juergen; Charnvanichborikarn, Supakit; Kucheyev, Sergei; Montalvo, Elizabeth; Shin, Swanee; Tylski, Elijah

    2017-03-21

    A composition comprising at least one high-density graphene-based monolith, said monolith comprising a three-dimensional structure of graphene sheets crosslinked by covalent carbon bonds and having a density of at least 0.1 g/cm.sup.3. Also provided is a method comprising: preparing a reaction mixture comprising a suspension and at least one catalyst, said suspension selected from a graphene oxide (GO) suspension and a carbon nanotube suspension; curing the reaction mixture to produce a wet gel; drying the wet gel to produce a dry gel, said drying step is substantially free of supercritical drying and freeze drying; and pyrolyzing the dry gel to produce a high-density graphene-based monolith. Exceptional combinations of properties are achieved including high conductive and mechanical properties.

  1. High density high performance plasma with internal diffusion barrier in Large Helical Device

    International Nuclear Information System (INIS)

    Sakamoto, R.; Kobayashi, M.; Miyazawa, J.

    2008-10-01

    A attractive high density plasma operational regime, namely an internal diffusion barrier (IDB), has been discovered in the intrinsic helical divertor configuration on the Large Helical Device (LHD). The IDB which enables core plasma to access a high density/high pressure regime has been developed. It is revealed that the IDB is reproducibly formed by pellet fueling in the magnetic configurations shifted outward in major radius. Attainable central plasma density exceeds 1x10 21 m -3 . Central pressure reaches 1.5 times atmospheric pressure and the central β value becomes fairly high even at high magnetic field, i.e. β(0)=5.5% at B t =2.57 T. (author)

  2. Carbon-coated magnetic nanobeads for the synthesis and recycling of high-density catalytic systems

    OpenAIRE

    Linhardt, Roland

    2015-01-01

    The present dissertation deals with the immobilization of organo- and transition metal catalysts on the surface of magnetic, carbon-coated Fe or Co nanoparticles. With the introduction of polymeric structures or stabilizing groups, the preparation of catalysts with an extremely high surface density (1.3-4.0 mmol g-1) is possible. The high-density materials can be efficiently applied in catalysis including facile recovery and recycling due to its highly magnetic properties. Chapter 1 demon...

  3. Single-Step Fabrication of High-Density Microdroplet Arrays of Low-Surface-Tension Liquids.

    Science.gov (United States)

    Feng, Wenqian; Li, Linxian; Du, Xin; Welle, Alexander; Levkin, Pavel A

    2016-04-01

    A facile approach for surface patterning that enables single-step fabrication of high-density arrays of low-surface-tension organic-liquid microdroplets is described. This approach enables miniaturized and parallel high-throughput screenings in organic solvents, formation of homogeneous arrays of hydrophobic nanoparticles, polymer micropads of specific shapes, and polymer microlens arrays. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Development and validation of a high-density\\ud SNP genotyping array for African Oil Palm

    OpenAIRE

    Kwong, Qi Bin; Teh, Chee Keng; Ong, Ai Ling; Heng, Huey Ying; Lee, Heng Leng; Mohamed, Mohaimi; Low, Joel Zi-Bin; Apparow, Sukganah; Chew, Fook Tim; Mayes, Sean; Kulaveerasingam, Harikrishna; Tammi, Martti; Appleton, David Ross; Sime Darby Technology Centre

    2016-01-01

    High-density single nucleotide polymorphism (SNP) genotyping arrays are powerful tools that can measure the level of genetic polymorphism within a population. To develop a whole-genome SNP array for oil palms, SNP discovery was performed using deep resequencing of eight libraries derived from 132 Elaeis guineensis and Elaeis oleifera palms belonging to 59 origins, resulting in the discovery of >3 million putative SNPs. After SNP filtering, the Illumina OP200K custom array was built with 170 8...

  5. Polymer-coated pH-responsive high-density lipoproteins.

    OpenAIRE

    Kim Hyungjin; Okamoto Haruki; Felber Arnaud E; Polomska Anna; Morone Nobuhiro; Heuser John E; Leroux Jean-Christophe; Murakami Tatsuya

    2016-01-01

    Intracellular drug delivery by nanoparticles is often hampered by their endosomal entrapment followed by their degradation in the lysosomal compartment and/or exocytosis. Here we show that internalization and endosomal escape of cargoes in a cationized natural nanocarrier high density lipoprotein (HDL) can be controlled in a pH dependent manner through stable complexation with a membranolytic anionic block polymer. A genetically and chemically cationized form of HDL (catHDL) is prepared for t...

  6. Evaluation of Pyrus and Quince rootstocks for high density pear orchards

    OpenAIRE

    Maas, F.M.

    2006-01-01

    High density planting systems are a prerequisite to economise the use of land and labour costs of orchards. Dwarfing rootstocks controlling the vigour of the scion cultivars form the basis for such orchards (Wertheim and Webster, 2005). In the Netherlands, rootstock research is limited to and focussed on testing rootstocks selected abroad. For the Dutch pear growers the main selection criteria for new rootstocks are: 1) control of tree size; 2) production; 3) fruit size; 4) fruit quality; 5) ...

  7. Cooling of high-density and power electronics by means of heat pipes

    International Nuclear Information System (INIS)

    Hubbeling, L.

    1980-06-01

    This report describes how heat pipes can be used for cooling modern electronic equipment, with numerous advantages over air-cooled systems. A brief review of heat-pipe properties is given, with a detailed description of a functioning prototype. This is a single-width CAMAC unit containing high-density electronic circuits cooled by three heat pipes, and allowing a dissipation of over 120 W instead of the normal maximum of 20 W. (orig.)

  8. Slow-transit Constipation.

    Science.gov (United States)

    Bharucha, Adil E.; Philips, Sidney F.

    2001-08-01

    Idiopathic slow-transit constipation is a clinical syndrome predominantly affecting women, characterized by intractable constipation and delayed colonic transit. This syndrome is attributed to disordered colonic motor function. The disorder spans a spectrum of variable severity, ranging from patients who have relatively mild delays in transit but are otherwise indistinguishable from irritable bowel syndrome to patients with colonic inertia or chronic megacolon. The diagnosis is made after excluding colonic obstruction, metabolic disorders (hypothyroidism, hypercalcemia), drug-induced constipation, and pelvic floor dysfunction (as discussed by Wald ). Most patients are treated with one or more pharmacologic agents, including dietary fiber supplementation, saline laxatives (milk of magnesia), osmotic agents (lactulose, sorbitol, and polyethylene glycol 3350), and stimulant laxatives (bisacodyl and glycerol). A subtotal colectomy is effective and occasionally is indicated for patients with medically refractory, severe slow-transit constipation, provided pelvic floor dysfunction has been excluded or treated.

  9. Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

    Science.gov (United States)

    Liao, Steve M.; Gregg, Nick M.; White, Brian R.; Zeff, Benjamin W.; Bjerkaas, Katelin A.; Inder, Terrie E.; Culver, Joseph P.

    2010-03-01

    The neurodevelopmental outcome of neonatal intensive care unit (NICU) infants is a major clinical concern with many infants displaying neurobehavioral deficits in childhood. Functional neuroimaging may provide early recognition of neural deficits in high-risk infants. Near-infrared spectroscopy (NIRS) has the advantage of providing functional neuroimaging in infants at the bedside. However, limitations in traditional NIRS have included contamination from superficial vascular dynamics in the scalp. Furthermore, controversy exists over the nature of normal vascular, responses in infants. To address these issues, we extend the use of novel high-density NIRS arrays with multiple source-detector distances and a superficial signal regression technique to infants. Evaluations of healthy term-born infants within the first three days of life are performed without sedation using a visual stimulus. We find that the regression technique significantly improves brain activation signal quality. Furthermore, in six out of eight infants, both oxy- and total hemoglobin increases while deoxyhemoglobin decreases, suggesting that, at term, the neurovascular coupling in the visual cortex is similar to that found in healthy adults. These results demonstrate the feasibility of using high-density NIRS arrays in infants to improve signal quality through superficial signal regression, and provide a foundation for further development of high-density NIRS as a clinical tool.

  10. Synthesis of high density aviation fuel with cyclopentanol derived from lignocellulose

    Science.gov (United States)

    Sheng, Xueru; Li, Ning; Li, Guangyi; Wang, Wentao; Yang, Jinfan; Cong, Yu; Wang, Aiqin; Wang, Xiaodong; Zhang, Tao

    2015-01-01

    For the first time, renewable high density aviation fuels were synthesized at high overall yield (95.6%) by the Guerbet reaction of cyclopentanol which can be derived from lignocellulose, followed by the hydrodeoxygenation (HDO). The solvent-free Guerbet reaction of cyclopentanol was carried out under the co-catalysis of solid bases and Raney metals. Among the investigated catalyst systems, the combinations of magnesium-aluminium hydrotalcite (MgAl-HT) and Raney Ni (or Raney Co) exhibited the best performances. Over them, high carbon yield (96.7%) of C10 and C15 oxygenates was achieved. The Guerbet reaction products were further hydrodeoxygenated to bi(cyclopentane) and tri(cyclopentane) over a series of Ni catalysts. These alkanes have high densities (0.86 g mL−1 and 0.91 g mL−1) and can be used as high density aviation fuels or additives to bio-jet fuel. Among the investigated HDO catalysts, the 35 wt.% Ni-SiO2-DP prepared by deposition-precipitation method exhibited the highest activity. PMID:25826744

  11. X-ray CT high-density artefact suppression in the presence of bones

    Energy Technology Data Exchange (ETDEWEB)

    Wei Jikun [School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907-2051 (United States); Chen Laigao [BioImaging Center of Emphasis, Pfizer Global Research and Development, 2800 Plymouth RD, Ann Arbor, MI 48105 (United States); Sandison, George A [School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907-2051 (United States); Liang Yun [Department of Radiology, Indiana University Medical School, Indianapolis, IN 46202 (United States); Xu, Lisa X [School of Mechanical Engineering, 585 Purdue Mall, West Lafayette, IN 47907-2040 (United States)

    2004-12-21

    This paper presents a novel method of reducing x-ray CT high-density artefacts generated by metal objects when abundant bone structures are present in the region of interest. This method has an advantage over previously proposed methods since it heavily suppresses the metal artefacts without introducing extra bone artefacts. The method of suppression requires that bone pixels are isolated and segmented by thresholding. Then artificial CT numbers are assigned to the bone pixels so that their projection profiles are smooth and thus can be properly simulated by a polynomial interpolation. The projection profile of the metal object is then removed to fully suppress the artefacts. The resulting processed profile is fed to a reconstruction routine and the previously preserved bone pixels added back. The new method utilizes two important features of the CT image with metal artefacts: (a) metal and bone pixels are not severely affected by the high-density artefacts and (b) the high-density artefacts can be located in specific projection channels in the profile domain, although they are spread out in the image domain. This suppression method solves the problem of CT image artefacts arising from metal objects in the body. It has the potential to greatly improve diagnostic CT imaging in the presence of these objects and treatment planning that utilizes CT for patients with metal applicators (e.g., brachytherapy for cervix cancer and prostate cryotherapy)

  12. Investigation of photon shielding property changes in curing high density concrete.

    Science.gov (United States)

    Marsh, Matthew B; Peters, Christopher; Rawluk, Nicholas; Schreiner, L John

    2013-10-01

    High density concrete is usually used for radiation shielding around radiotherapy treatment rooms. Because the concrete is specified differently at the design, construction, and verification stages, the relationship between the intended performance and the actual performance of the shielding material might not be entirely clear. In this study, cylindrical samples of high density shielding concrete were taken as each section of a new radiotherapy bunker was poured. The shielding performance of each sample [measured by beam attenuation and tenth-value layers (TVL)] was evaluated for 15 MV and 6 MV x-ray beams and for the 1.25 MeV monoenergetic gamma beam from a Co source. Transmission curves to 3 TVL were mapped for a representative sample. The samples were also imaged and analyzed using Co Cone Beam Computed Tomography (CoCBCT). Results indicate no significant change in the TVL of high density concrete samples as they cure. The minor fluctuations in shielding properties observed are explained by the heterogeneous structure of the samples as indicated in the CoCBCT images.

  13. Low-enriched uranium high-density target project. Compendium report

    Energy Technology Data Exchange (ETDEWEB)

    Vandegrift, George; Brown, M. Alex; Jerden, James L.; Gelis, Artem V.; Stepinski, Dominique C.; Wiedmeyer, Stanley; Youker, Amanda; Hebden, Andrew; Solbrekken, G; Allen, C; Robertson., D; El-Gizawy, Sherif; Govindarajan, Srisharan; Hoyer, Annemarie; Makarewicz, Philip; Harris, Jacob; Graybill, Brian; Gunn, Andy; Berlin, James; Bryan, Chris; Sherman, Steven; Hobbs, Randy; Griffin, F. P.; Chandler, David; Hurt, C. J.; Williams, Paul; Creasy, John; Tjader, Barak; McFall, Danielle; Longmire, Hollie

    2016-09-01

    At present, most 99Mo is produced in research, test, or isotope production reactors by irradiation of highly enriched uranium targets. To achieve the denser form of uranium needed for switching from high to low enriched uranium (LEU), targets in the form of a metal foil (~125-150 µm thick) are being developed. The LEU High Density Target Project successfully demonstrated several iterations of an LEU-fission-based Mo-99 technology that has the potential to provide the world’s supply of Mo-99, should major producers choose to utilize the technology. Over 50 annular high density targets have been successfully tested, and the assembly and disassembly of targets have been improved and optimized. Two target front-end processes (acidic and electrochemical) have been scaled up and demonstrated to allow for the high-density target technology to mate up to the existing producer technology for target processing. In the event that a new target processing line is started, the chemical processing of the targets is greatly simplified. Extensive modeling and safety analysis has been conducted, and the target has been qualified to be inserted into the High Flux Isotope Reactor, which is considered above and beyond the requirements for the typical use of this target due to high fluence and irradiation duration.

  14. X-ray CT high-density artefact suppression in the presence of bones

    International Nuclear Information System (INIS)

    Wei Jikun; Chen Laigao; Sandison, George A; Liang Yun; Xu, Lisa X

    2004-01-01

    This paper presents a novel method of reducing x-ray CT high-density artefacts generated by metal objects when abundant bone structures are present in the region of interest. This method has an advantage over previously proposed methods since it heavily suppresses the metal artefacts without introducing extra bone artefacts. The method of suppression requires that bone pixels are isolated and segmented by thresholding. Then artificial CT numbers are assigned to the bone pixels so that their projection profiles are smooth and thus can be properly simulated by a polynomial interpolation. The projection profile of the metal object is then removed to fully suppress the artefacts. The resulting processed profile is fed to a reconstruction routine and the previously preserved bone pixels added back. The new method utilizes two important features of the CT image with metal artefacts: (a) metal and bone pixels are not severely affected by the high-density artefacts and (b) the high-density artefacts can be located in specific projection channels in the profile domain, although they are spread out in the image domain. This suppression method solves the problem of CT image artefacts arising from metal objects in the body. It has the potential to greatly improve diagnostic CT imaging in the presence of these objects and treatment planning that utilizes CT for patients with metal applicators (e.g., brachytherapy for cervix cancer and prostate cryotherapy)

  15. Slowing Military Change

    Science.gov (United States)

    2008-10-01

    subjective. More objective measurements, such as statistics on youth crime, teenage pregnancy , drug use, literacy, and educational achievement...SLOWING MILITARY CHANGE Zhivan J. Alach October 2008 This publication is a work of the U.S. Government as defined in Title 17, United States Code...those of the author and do not necessarily reflect the official policy or position of the New Zealand Defence Force, the New Zealand Government , the

  16. Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine

    Science.gov (United States)

    Barash, N. R.; Nosala, C.; Pham, J. K.; McInally, S. G.; Gourguechon, S.; McCarthy-Sinclair, B.

    2017-01-01

    ABSTRACT Giardia lamblia is a highly prevalent yet understudied protistan parasite causing significant diarrheal disease worldwide. Hosts ingest Giardia cysts from contaminated sources. In the gastrointestinal tract, cysts excyst to become motile trophozoites, colonizing and attaching to the gut epithelium. Trophozoites later differentiate into infectious cysts that are excreted and contaminate the environment. Due to the limited accessibility of the gut, the temporospatial dynamics of giardiasis in the host are largely inferred from laboratory culture and thus may not mirror Giardia physiology in the host. Here, we have developed bioluminescent imaging (BLI) to directly interrogate and quantify the in vivo temporospatial dynamics of Giardia infection, thereby providing an improved murine model to evaluate anti-Giardia drugs. Using BLI, we determined that parasites primarily colonize the proximal small intestine nonuniformly in high-density foci. By imaging encystation-specific bioreporters, we show that encystation initiates shortly after inoculation and continues throughout the duration of infection. Encystation also initiates in high-density foci in the proximal small intestine, and high density contributes to the initiation of encystation in laboratory culture. We suggest that these high-density in vivo foci of colonizing and encysting Giardia likely result in localized disruption to the epithelium. This more accurate visualization of giardiasis redefines the dynamics of the in vivo Giardia life cycle, paving the way for future mechanistic studies of density-dependent parasitic processes in the host. IMPORTANCE Giardia is a single-celled parasite causing significant diarrheal disease in several hundred million people worldwide. Due to limited access to the site of infection in the gastrointestinal tract, our understanding of the dynamics of Giardia infections in the host has remained limited and largely inferred from laboratory culture. To better understand

  17. Long-term ethanol consumption impairs reverse cholesterol transport function of high-density lipoproteins by depleting high-density lipoprotein sphingomyelin both in rats and in humans.

    Science.gov (United States)

    Marmillot, Philippe; Munoz, Jennifer; Patel, Sanket; Garige, Mamatha; Rosse, Richard B; Lakshman, M Raj

    2007-07-01

    Moderate alcohol consumption has been linked to lower incidence of coronary artery disease due to increased plasma high-density lipoprotein (HDL), whereas heavy drinking has the opposite effect. Because of the crucial role of HDL in reverse cholesterol transport and positive correlation of HDL sphingomyelin (SM) content with cholesterol efflux, we have compared HDL SM content with its reverse cholesterol transport capacity both in rats fed ethanol on long-term basis and alcoholic individuals. In rats, SM HDL content was decreased in the ethanol group (-15.4%, P cholesterol uptake with control-group hepatocytes and 35.0% (P cholesterol uptake with ethanol-group hepatocytes. Conversely, hepatocytes from the ethanol group, when compared with hepatocytes from the control group, exhibited 31.0% (P cholesterol uptake with control-group HDL and 48.0% (P alcoholic individuals without liver disease (-51.5%, P alcoholic individuals with liver disease (-51.3%, P alcoholic individuals without liver disease, both efflux and uptake were decreased by 83.0% and 54.0% (P alcoholic individuals with liver disease by 84.0% and 61.0% (P consumption significantly impairs not only cholesterol efflux function of HDL by decreasing its SM content but also cholesterol uptake by affecting presumably hepatocyte receptors for HDL.

  18. Slow Food arjessa : Case Slow Food ruokakurssi Kristiinankaupungin Kansalaisopistossa

    OpenAIRE

    Mäenpää, Minna-Maria

    2015-01-01

    Opinnäytetyössäni esittelen Slow Food -järjestön toimintaa kansainvälisesti ja Slow Food -henkistä toimintaa Kristiinankaupungissa. Yhdistin teoriaosuuteen yhdessä Kristiinankaupungin kansalaisopiston ja Perunaelinkeinoalan kehittämishankkeen kanssa Kristiinankaupungissa järjestämäni Slow Food arjessa -kurssin. Tutkimuksen ongelmana oli luoda kurssikonsepti, jossa Slow Food -henkinen tiedottaminen esimerkiksi alueemme ruoantuottajista yhdistettiin varsinaiseen ruoan valmistamiseen. Keräsin tä...

  19. The neural dynamics of somatosensory processing and adaptation across childhood: a high-density electrical mapping study

    Science.gov (United States)

    Uppal, Neha; Foxe, John J.; Butler, John S.; Acluche, Frantzy

    2016-01-01

    Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6–18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ∼7 to ∼1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1–9.8, 10.0–12.9, and 13.0–17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ∼7 yr of age. PMID:26763781

  20. The neural dynamics of somatosensory processing and adaptation across childhood: a high-density electrical mapping study.

    Science.gov (United States)

    Uppal, Neha; Foxe, John J; Butler, John S; Acluche, Frantzy; Molholm, Sophie

    2016-03-01

    Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6-18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ∼7 to ∼1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1-9.8, 10.0-12.9, and 13.0-17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ∼7 yr of age. Copyright © 2016 the American Physiological Society.

  1. Intraindividual Increase of Homeostatic Sleep Pressure Across Acute and Chronic Sleep Loss: A High-Density EEG Study.

    Science.gov (United States)

    Maric, Angelina; Lustenberger, Caroline; Werth, Esther; Baumann, Christian R; Poryazova, Rositsa; Huber, Reto

    2017-09-01

    To compare intraindividually the effects of acute sleep deprivation (ASD) and chronic sleep restriction (CSR) on the homeostatic increase in slow wave activity (SWA) and to relate it to impairments in basic cognitive functioning, that is, vigilance. The increase in SWA after ASD (40 hours of wakefulness) and after CSR (seven nights with time in bed restricted to 5 hours per night) relative to baseline sleep was assessed in nine healthy, male participants (age = 18-26 years) by high-density electroencephalography. The SWA increase during the initial part of sleep was compared between the two conditions of sleep loss. The increase in SWA was related to the increase in lapses of vigilance in the psychomotor vigilance task (PVT) during the preceding days. While ASD induced a stronger increase in initial SWA than CSR, the increase was globally correlated across the two conditions in most electrodes. The increase in initial SWA was positively associated with the increase in PVT lapses. The individual homeostatic response in SWA is globally preserved across acute and chronic sleep loss, that is, individuals showing a larger increase after ASD also do so after CSR and vice versa. Furthermore, the increase in SWA is globally correlated to vigilance impairments after sleep loss over both conditions. Thus, the increase in SWA might therefore provide a physiological marker for individual differences in performance impairments after sleep loss. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  2. Go, Slow, and Whoa Foods

    Science.gov (United States)

    ... tips for seasonal health, safety and fun Go, Slow, and Whoa Foods Past Issues / Summer 2007 Table of Contents For ... Inc. 2002 Food Group GO Almost anytime foods SLOW Sometimes foods WHOA Once in a while foods Vegetables Almost ...

  3. Use of a high density lead glass tubing projection chamber in positron emission tomography and in high energy physics

    International Nuclear Information System (INIS)

    Conti, M.; Guerra, A.D.; Habel, R.; Mulera, T.; Perez-Mendez, V.; Schwartz, G.

    1985-10-01

    We describe the principle of operation of a high density Projection Chamber, in which the converter/radiator and drift field shaping structures are combined in the form of high density (5 to 6 g/cm 3 ) lead glass tubing. The main applications of this type of detector to Medical Physics (Positron Emission Tomography) and High Energy Physics (Electromagnetic Calorimetry) are discussed

  4. Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease

    DEFF Research Database (Denmark)

    Wittrup, Hans H; Andersen, Rolf V; Tybjaerg-Hansen, Anne

    2006-01-01

    Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD).......Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)....

  5. Pruning for crop regulation in high density guava (Psidium guajava L.) plantation

    Energy Technology Data Exchange (ETDEWEB)

    Thakre, M.; Lal, S.; Uniyal, S.; Goswami, A.K. Prakash. P.

    2016-11-01

    High density management and crop regulation are two important aspects in guava (Psidium guajava L.) production. Therefore, to find out the economic way of managing high density planting and crop regulation, the present work was carried out on 6-year-old guava trees of cv. Pant Prabhat under double-hedge row system of planting during 2009-10 and 2010-11. Seven different forms of pruning [FBT: flower bud thinning by hand, FBTT: flower bud thinning by hand followed by removal of terminal one leaf pair, RLFO: removal of leaves and flower buds by hand, retaining one leaf pair at the top, RLF: removal of all leaves and flowers by hand, OLPS: one leaf pair shoot pruning, FSP: full shoot pruning, OLPF: one leaf pair pruning of fruited shoots only] were studied along with control (C).Minimum annual increase in tree volume (6.764 m3) was recorded with the treatment OLPF, which was 2.31 times less than the control (15.682 m3). Highest yield during winter season (55.30 kg/tree) and total yield (59.87 kg/tree) was obtained from treatment OLPF. One leaf pair pruning of fruited shoots only (OLPF) was also found profitable among other treatments by recording cost:benefit ratio of 1:2.96. This treatment also recorded the highest return distributed in rainy as well as in winter season. On the basis of findings it can be concluded that one leaf pair pruning of fruited shoots only is suitable for profitable high density management as well as crop regulation of guava in farmer friendly manner. (Author)

  6. An approach to conifer stem localization and modeling in high density airborne LiDAR data

    Science.gov (United States)

    Harikumar, A.; Bovolo, F.; Bruzzone, L.

    2017-10-01

    Individual tree level inventory performed using high density multi-return airborne Light Detection and Ranging (LiDAR) systems provides both internal and external geometric details on individual tree crowns. Among them, the parameters such as, the stem location, and Diameter at Breast Height of the stem (DBH) are very relevant for accurate biomass, and forest growth estimation. However, methods that can accurately estimate these parameters along the vertical canopy are lacking in the state of the art. Thus, we propose a method to locate and model the stem by analyzing the empty volume that appears within the 3D high density LiDAR point cloud of a conifer, due to the stem. In a high LiDAR density data, the points most proximal to the stem location in the upper half of the crown are very likely due to laser reflections from the stem and/or the branch-stem junctions. By locating accurately these points, we can define the lattice of points representing branch-stem junctions and use it to model the empty volume associated to the stem location. We identify these points by using a state-of-the-art internal crown structure modelling technique that models individual conifer branches in a high density LiDAR data. Under the assumption that conifer stem can be closely modelled using a cone shape, we regression fit a geometric shape onto the lattice of branch-stem junction points. The parameters of the geometric shape are used to accurately estimate the diameter at breast height, and height of the tree. The experiments were performed on a set of hundred conifers consisting of trees from six dominant European conifer species, for which the height and the DBH were known. The results prove the method to be accurate.

  7. Hydrological impact of high-density small dams in a humid catchment, Southeast China

    Science.gov (United States)

    Lu, W.; Lei, H.; Yang, D.

    2017-12-01

    The Jiulong River basin is a humid catchment with a drainage area of 14,741 km2; however, it has over 1000 hydropower stations within it. Such catchment with high-density small dams is scarce in China. Yet few is known about the impact of high-density small dams on streamflow changes. To what extent the large number of dams alters the hydrologic patterns is a fundamental scientific issue for water resources management, flood control, and aquatic ecological environment protection. Firstly, trend and change point analyses are applied to determine the characteristics of inter-annual streamflow. Based on the detected change point, the study period is divided into two study periods, the ``natural'' and ``disturbed'' periods. Then, a geomorphology-based hydrological model (GBHM) and the fixing-changing method are adopted to evaluate the relative contributions of climate variations and damming to the changes in streamflow at each temporal scale (i.e., from daily, monthly to annual). Based on the simulated natural streamflow, the impact of dam construction on hydrologic alteration and aquatic ecological environment will be evaluated. The hydrologic signatures that will be investigated include flood peak, seasonality of streamflow, and the inter-annual variability of streamflow. In particular, the impacts of damming on aquatic ecological environment will be investigated using eco-flow metrics and indicators of hydrologic alteration (IHA) which contains 33 individual streamflow statistics that are closely related to aquatic ecosystem. The results of this study expect to provide a reference for reservoir operation considering both ecological and economic benefits of such operations in the catchment with high-density dams.

  8. A study of HANARO core conversion using high density U-Mo fuel

    International Nuclear Information System (INIS)

    Lee, K.H.; Lee, C.S.; Lee, B.C.; Park, S.J.; Kim, H.; Kim, C.K.

    2002-01-01

    Currently, HANARO is using 3.15gU/cc U3Si/Al as a driver fuel. HANARO has seven vertical irradiation holes in the core region. Three of them including a central trap are located in the inner region of the core and mainly being used for material irradiation tests. Four of them are located in the reflector tank but cooled by primary coolant. They are used for fuel irradiation tests or radioisotope development tests. For minimum core modification using high density U-Mo fuels, no dimension change is assumed in the current fuel rods and the cladding thickness remains the same in this study. The high density U-Mo fuel will have up to about twice the linear uranium loading of a current HANARO driver fuel. Using this high density fuel 8 fuel sites can be replaced with irradiation sites. Three kinds of conceptual cores are considered using 5 gU/cc U-7Mo/Al and 16 gU/cc U-7Mo. The increase of the linear heat generation rate due to the decrease of total fuel length can be overcome by more uniform radial and axial power distribution using different uranium densities and different fuel meat diameters are introduced into those cores. The new core has 4.54 times larger surface-to-volume ratio than the reference core. The core uranium loading, linear heat generation rate, excess reactivity, and control rod worth as well as the neutron spectra are analysed for each core. (author)

  9. Cylindrical implosion to measure the radiative properties of high density and temperature plasmas

    International Nuclear Information System (INIS)

    Xu Yan; Rose, S.J.

    2000-01-01

    Cylindrical implosion is of great interest because of its excellent diagnostic access. The authors present one-dimensional numerical simulations to explore the plasma conditions that may be achieved. Combined with the numerical data, the development of Rayleigh-Taylor instabilities and Richtmyer-Meshkov instabilities in those targets are estimated. The authors found that it is possible to achieve a high density and temperature plasma with a relatively low temperature and density gradient using a cylindrical implosion directly-driven by a high-power laser

  10. In vitro experiments for the development of a high density (HD) barium sulfate contrast medium

    International Nuclear Information System (INIS)

    Klein, J.

    1986-01-01

    In vitro experiments with the high-density (HD) barium meal Falibaryt HD are described. Several charges of BaSO 4 were tested together with certain additives influencing dispersion, stability of the suspension, flowability, surface tension etc. Particle size spectra were measured by the manufacturer, VEB Fahlberg-List. With a simple PVC test plate containing several grooves simulating small details (areae gastricae) the diagnostic capabilities of the HD contrast medium were evaluated in an in vitro test. The developed barium meal Falibaryt HD is in its physical and chemical parameters comparable with Prontobario-HD, one of the best HD barium meals. (author)

  11. Thermal Stability and Rheological Behaviors of High-Density Polyethylene/Fullerene Nanocomposites

    OpenAIRE

    Zhao, Liping; Song, Ping'an; Cao, Zhenhu; Fang, Zhengping; Guo, Zhenghong

    2012-01-01

    High-density polyethylene/fullerene (HDPE/C60) nanocomposites with the C60 loading that varied from 0.5 to 5.0% by weight were prepared via melt compounding. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) results showed that the presence of C60 could remarkably enhance the thermal properties of HDPE. A very low C60 loading (0.5 wt%) increased the onset degradation temperature from 3 8 9 ∘ C to 4 5 9 ∘ C and decreased the heat release from 3176 J/g to 1490 J/g. Th...

  12. Triton-3He relative and differential flows and the high density behavior of nuclear symmetry

    International Nuclear Information System (INIS)

    Yong, Gaochan; Li, Baoan; Chen, Liewen

    2010-01-01

    Using a transport model coupled with a phase-space coalescence after-burner we study the triton- 3 He relative and differential transverse flows in semi-central 132 Sn + 124 Sn reactions at a beam energy of 400 MeV/nucleon. We find that the triton- 3 He pairs carry interesting information about the density dependence of the nuclear symmetry energy. The t- 3 He relative flow can be used as a particularly powerful probe of the high-density behavior of the nuclear symmetry energy. (author)

  13. High-density EMG e-textile systems for the control of active prostheses

    DEFF Research Database (Denmark)

    Farina, Dario; Lorrain, Thomas; Negro, Francesco

    2010-01-01

    Myoelectric control of active prostheses requires electrode systems that are easy to apply for daily repositioning of the electrodes by the user. In this study we propose the use of Smart Fabric and Interactive Textile (SFIT) systems as an alternative solution for recording high-density EMG signals...... for myoelectric control. A sleeve covering the upper and lower arm, which contains 100 electrodes arranged in four grids of 5 * 5 electrodes, was used to record EMG signals in 3 subjects during the execution of 9 tasks of the wrist and hand. The signals were analyzed by extracting wavelet coefficients which were...

  14. PRODUCTION OF HIGH DENSITY PARTICLEBOARD USING MELAMINE-UREA-FORMALDEHYDE RESIN

    Directory of Open Access Journals (Sweden)

    Setsuo Iwakiri

    2005-12-01

    Full Text Available This research was developed aiming to evaluate the effects of board density and melamine-urea-formaldehyde resin onthe properties of particleboard for semi-structural applications. The boards were manufactured with nominal density of 0.65 g/cm³and 0.90 g/cm³ using urea-formaldehyde resin as control and melamine-urea-formaldehyde. The results showed a better dimensionallystability and mechanical properties of the boards manufactured with higher density and MUF resin content. The fine furnish usedfor external layer of particleboard in the industrial process, could be used for high density homogeneous board to semi-strucuturaluses, such as flooring applications.

  15. Polyethylene Terephthalate (Pete) And High Density Polyethylene (Hdpe) Mixture To Fuel Production

    OpenAIRE

    Moinuddin Sarker

    2013-01-01

    High density polyethylene (HDPE) and polyethylene terephthalate (PETE) mixture to fuel production process was performed with Ferric Oxide (Fe2O3) and activated carbon. HDPE waste plastic was use 75 gm, PETE was use 25 gm, activated carbon was use 5 gm as a 5% and Ferric Oxide was use 2 gm as a 1%. PETE and HDPE waste plastics mixture to fuel production process temperature was use 420 ºC and reactor was use Pyrex glass reactor. Total waste plastics sample was 100 gm and 100 gm of waste plastic...

  16. High-density polyethylene pipe: A new material for pass-by passive integrated transponder antennas

    Science.gov (United States)

    Kazyak, David C.; Zydlewski, Joseph D.

    2012-01-01

    Pass-by passive integrated transponder (PIT) antennas are widely used to study the movements of fish in streams. At many sites, stream conditions make it difficult to maintain antennas and obtain a continuous record of movement. We constructed pass-by PIT antennas by using high-density polyethylene (HDPE) and found them to be robust to high flows and winter ice flows. Costs for HDPE antennas were similar to those of traditional polyvinyl chloride (PVC) antennas, although construction was somewhat more complicated. At sites where PVC antennas are frequently damaged, HDPE is a durable and economical alternative for PIT antenna construction.

  17. Multilevel SOT-MRAM Cell with a Novel Sensing Scheme for High-Density Memory Applications

    DEFF Research Database (Denmark)

    Zeinali, Behzad; Esmaeili, Mahsa; Madsen, Jens Kargaard

    2017-01-01

    in high-density memory application. To deal with this obstacle, we propose a multilevel cell which stores two bits per memory cell. In addition, we propose a novel sensing scheme to read out the stored data in the multilevel SOT-MRAM cell. Our simulation results show that the proposed cell can achieve 3X......This paper presents a multilevel spin-orbit torque magnetic random access memory (SOT-MRAM). The conventional SOT-MRAMs enables a reliable and energy efficient write operation. However, these cells require two access transistors per cell, hence the efficiency of the SOTMRAMs can be questioned...

  18. Reduced scattering-matrix algorithm for high-density plasmonic structures.

    Science.gov (United States)

    Bouchon, Patrick; Pardo, Fabrice; Haïdar, Riad; Vincent, Grégory; Pelouard, Jean-Luc

    2010-10-01

    We describe a method to compute S-matrix interface terms using a selection of eigenmodes. When solving the modal equation, the computation of left and right eigenvectors leads to rectangular eigenmodes matrices. Expressions of S-matrix interface terms are then expressed so as to allow for a significant reduction of the computation cost. The reduction is even further decreased in the case of the B-spline modal method, which deals with sparse matrices. Its convergence is illustrated on a high-density plasmonic structure and compared to a full modal method.

  19. On the use of High-density rock in rubble Mound Breakwaters

    DEFF Research Database (Denmark)

    Helgason, Einar; Burcharth, H. F.

    2005-01-01

    Natural rock with high density is widely used in the Scandinavian countries. However, the use of natural rock with density higher than 2:9t=m3 is ordinarily associated with some kind of problem solving, e.g. where normal density stones have to be replaced with heavier stones without increasing...... on stability from the increased density is overestimated by conventional armour stability formulae in case of steep slopes. The infuence of the density depends on the slope angle and the type of armour units....

  20. A high density genetic map of maritime pine based on AFLPs

    OpenAIRE

    Chagné, David; Lalanne, Céline; Madur, Delphine; Kumar, Satish; Frigério, Jean-Marc; Krier, Catherine; Decroocq, Stéphane; Savouré, Arnould; Magida Bou-Dagher-Kharrat,; Bertocchi, Evangelista; Brach, Jean; Plomion, Christophe

    2002-01-01

    International audience; We constructed a high-density linkage map of maritime pine (Pinus pinaster Ait.) based on AFLP (Amplified Fragment Length Polymorphism) markers using a three-generation outbred pedigree. In a first step, male and female maps were established independently with test-cross markers segregating 1:1 (presence:absence of the amplified fragment in the full-sib progeny). In a second step, both maps were merged using intercross markers segregating 3:1 in the progeny. A combinat...

  1. Broadband infrared photoluminescence in silicon nanowires with high density stacking faults.

    Science.gov (United States)

    Li, Yang; Liu, Zhihong; Lu, Xiaoxiang; Su, Zhihua; Wang, Yanan; Liu, Rui; Wang, Dunwei; Jian, Jie; Lee, Joon Hwan; Wang, Haiyan; Yu, Qingkai; Bao, Jiming

    2015-02-07

    Making silicon an efficient light-emitting material is an important goal of silicon photonics. Here we report the observation of broadband sub-bandgap photoluminescence in silicon nanowires with a high density of stacking faults. The photoluminescence becomes stronger and exhibits a blue shift under higher laser powers. The super-linear dependence on excitation intensity indicates a strong competition between radiative and defect-related non-radiative channels, and the spectral blue shift is ascribed to the band filling effect in the heterostructures of wurtzite silicon and cubic silicon created by stacking faults.

  2. How Well Does BODIPY-Cholesteryl Ester Mimic Unlabeled Cholesteryl Esters in High Density Lipoprotein Particles?

    DEFF Research Database (Denmark)

    Karilainen, Topi; Vuorela, Timo; Vattulainen, Ilpo

    2015-01-01

    We compare the behavior of unlabeled and BODIPY-labeled cholesteryl ester (CE) in high density lipoprotein by atomistic molecular dynamics simulations. We find through replica exchange umbrella sampling and unbiased molecular dynamics simulations that BODIPY labeling has no significant effect...... on the partitioning of CE between HDL and the water phase. However, BODIPY-CE was observed to diffuse more slowly and locate itself closer to the HDL-water interface than CE due to the BODIPY probe that is constrained to the surface region, and because the CE body in BODIPY-CE prefers to align itself away from...

  3. Study and application of high-density concrete in radiation-shielding experiment

    International Nuclear Information System (INIS)

    Wu Chongming; Ding Dexin; Xiao Xuefu; Wang Shaolin; Lin Xingjun; Shen Yuanyuan

    2008-01-01

    According to the demand for research and construction project, a series of systematic experiments and studies on shielding γ-ray radiation concrete with the density of 4.60 t/m 3 were made in such aspects as mix ratio design, construction technology, uniformly shielding etc. Such issues as uniformity in the construction and compactness were solved. The ray test method for uniformly shielding concrete was presented and some technical steps for this high-density concrete used in the process of test design or construction were summed up. A series of tests and practical applications show that this technology of mix ratio design and construction is feasible. (authors)

  4. Superhydrophilic-Superhydrophobic Patterned Surfaces as High-Density Cell Microarrays: Optimization of Reverse Transfection.

    Science.gov (United States)

    Ueda, Erica; Feng, Wenqian; Levkin, Pavel A

    2016-10-01

    High-density microarrays can screen thousands of genetic and chemical probes at once in a miniaturized and parallelized manner, and thus are a cost-effective alternative to microwell plates. Here, high-density cell microarrays are fabricated by creating superhydrophilic-superhydrophobic micropatterns in thin, nanoporous polymer substrates such that the superhydrophobic barriers confine both aqueous solutions and adherent cells within each superhydrophilic microspot. The superhydrophobic barriers confine and prevent the mixing of larger droplet volumes, and also control the spreading of droplets independent of the volume, minimizing the variability that arises due to different liquid and surface properties. Using a novel liposomal transfection reagent, ScreenFect A, the method of reverse cell transfection is optimized on the patterned substrates and several factors that affect transfection efficiency and cytotoxicity are identified. Higher levels of transfection are achieved on HOOC- versus NH 2 -functionalized superhydrophilic spots, as well as when gelatin and fibronectin are added to the transfection mixture, while minimizing the amount of transfection reagent improves cell viability. Almost no diffusion of the printed transfection mixtures to the neighboring microspots is detected. Thus, superhydrophilic-superhydrophobic patterned surfaces can be used as cell microarrays and for optimizing reverse cell transfection conditions before performing further cell screenings. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Towards neuronal organoids: a method for long-term culturing of high-density hippocampal neurons.

    Directory of Open Access Journals (Sweden)

    George K Todd

    Full Text Available One of the goals in neuroscience is to obtain tractable laboratory cultures that closely recapitulate in vivo systems while still providing ease of use in the lab. Because neurons can exist in the body over a lifetime, long-term culture systems are necessary so as to closely mimic the physiological conditions under laboratory culture conditions. Ideally, such a neuronal organoid culture would contain multiple cell types, be highly differentiated, and have a high density of interconnected cells. However, before these types of cultures can be created, certain problems associated with long-term neuronal culturing must be addressed. We sought to develop a new protocol which may further prolong the duration and integrity of E18 rat hippocampal cultures. We have developed a protocol that allows for culturing of E18 hippocampal neurons at high densities for more than 120 days. These cultured hippocampal neurons are (i well differentiated with high numbers of synapses, (ii anchored securely to their substrate, (iii have high levels of functional connectivity, and (iv form dense multi-layered cellular networks. We propose that our culture methodology is likely to be effective for multiple neuronal subtypes-particularly those that can be grown in Neurobasal/B27 media. This methodology presents new avenues for long-term functional studies in neurons.

  6. Effects of welding parameters on friction stir spot welding of high density polyethylene sheets

    International Nuclear Information System (INIS)

    Bilici, Mustafa Kemal; Yukler, Ahmet Irfan

    2012-01-01

    Graphical abstract: (a) Schematic illustration of the cross section of a friction stir spot weld and (b) Geometry of the weld bonded area, x: nugget thickness and y: the thickness of the upper sheet. Highlights: → Welding parameters affect the FSSW nugget formation and the strength of the joint. → Melting of polyethylene occurred in the vicinity of the tool pin. → The joint that fractures with a pull nugget failure mode has a higher strength. -- Abstract: Friction stir spot welding parameters affect the weld strength of thermoplastics, such as high density polyethylene (HDPE) sheets. The effects of the welding parameters on static strength of friction stir spot welds of high density polyethylene sheets were investigated. For maximizing the weld strength, the selection of welding parameters is very important. In lap-shear tests two fracture modes were observed; cross nugget failure and pull nugget failure. The tool rotational speed, tool plunge depth and dwell time were determined to be important in the joint formation and its strength. The joint which had a better strength fails with a pull nugget failure morphology. Weld cross section image analysis of the joints were done with a video spectral comparator. The plunge rate of the tool was determined to have a negligible effect on friction stir spot welding.

  7. Improving the circular economy via hydrothermal processing of high-density waste plastics.

    Science.gov (United States)

    Helmer Pedersen, Thomas; Conti, Federica

    2017-10-01

    Rising environmental concerns on climate changes are causing an increasing attention on circular economies. The plastic economy, in particular, is in focus due to the accelerating consumption of plastics, mainly derived from virgin feedstock, combined with the lack of plastic recycling strategies. This work presents a novel outlook on the potential of using supercritical hydrothermal processing of waste plastic fractions for tertiary recycling. The study investigates hydrothermal processing of nine different, high-density types of plastics into original resin monomers and other value-added chemical compounds. The outlook presents conversion yields, carbon balances, and chemical details on the products obtained. It is found that all the investigated resins are prone to hydrothermal treatment, and that high yields of monomers and high value compounds (up to nearly 100%), suitable for chemicals and fuels applications, can be obtained. For instance, for polycarbonate, styrene-butadiene, poly(lactic acid), poly(ethylene terephthalate), and poly(butylene terephthalate), original monomeric compounds can be reclaimed for manufacturing new resins. The promising results presented demonstrate that hydrothermal processing of high-density plastics is a prospective technology for increasing the circularity of the plastic economy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Neutron star evolution and the structure of matter at high density

    International Nuclear Information System (INIS)

    Soyeur, Madeleine.

    1981-09-01

    The structure and properties of neutron stars are determined by the state of cold nuclear matter at high density. In order to investigate the behavior of matter inside neutron stars, observables sensitive to their internal structure have to be calculated and confronted to observations. The thermal radiation of neutron stars seems to be a good candidate to be such observable. It can be shown that the neutrino luminosity of neutron stars, responsible for their cooling in the early stages of their evolution is strongly dependent on possible phase transitions to superfluid nucleons, to pion condensation or to quark matter. The specific heat of matter is also not the same in the various phases expected at high density and is particularly sensitive to the nucleon superfluidity. At present, both the theoretical estimates and the observations of the thermal properties of neutron stars are still quite preliminary. In particular, large uncertainties due to possible reheating mechanisms and magnetic field effects make the theoretical interpretation of the steady radiation of pulsars quite difficult

  9. On the road to obesity: Television viewing increases intake of high-density foods.

    Science.gov (United States)

    Blass, Elliott M; Anderson, Daniel R; Kirkorian, Heather L; Pempek, Tiffany A; Price, Iris; Koleini, Melanie F

    2006-07-30

    Television viewing (TVV) has been linked with obesity, possibly through increased sedentary behavior and/or through increased ingestion during TVV. The proposition that TVV causes increased feeding, however, has not been subjected to experimental verification until recently. Our objective was to determine if the amount eaten of two familiar, palatable, high-density foods (pizza and macaroni and cheese) was increased during a 30-min meal when watching TV. In a within-subjects design, one group of undergraduates (n = 10) ate pizza while watching a TV show of their choice for one session and when listening to a symphony during the other session. A second group of undergraduates (n = 10) ate macaroni and cheese (M&C). TVV increased caloric intake by 36% (one slice on average) for pizza and by 71% for M&C. Eating patterns also differed between conditions. Although the length of time to eat a slice of pizza remained stable between viewing conditions, the amount of time before starting another slice was shorter during TVV. In contrast, M&C was eaten at a faster rate and for a longer period of time during TVV. Thus, watching television increases the amount eaten of high-density, palatable, familiar foods and may constitute one vector contributing to the current obesity crisis.

  10. StreamMap: Smooth Dynamic Visualization of High-Density Streaming Points.

    Science.gov (United States)

    Li, Chenhui; Baciu, George; Han, Yu

    2018-03-01

    Interactive visualization of streaming points for real-time scatterplots and linear blending of correlation patterns is increasingly becoming the dominant mode of visual analytics for both big data and streaming data from active sensors and broadcasting media. To better visualize and interact with inter-stream patterns, it is generally necessary to smooth out gaps or distortions in the streaming data. Previous approaches either animate the points directly or present a sampled static heat-map. We propose a new approach, called StreamMap, to smoothly blend high-density streaming points and create a visual flow that emphasizes the density pattern distributions. In essence, we present three new contributions for the visualization of high-density streaming points. The first contribution is a density-based method called super kernel density estimation that aggregates streaming points using an adaptive kernel to solve the overlapping problem. The second contribution is a robust density morphing algorithm that generates several smooth intermediate frames for a given pair of frames. The third contribution is a trend representation design that can help convey the flow directions of the streaming points. The experimental results on three datasets demonstrate the effectiveness of StreamMap when dynamic visualization and visual analysis of trend patterns on streaming points are required.

  11. Isotropic and high density carbon made from carbonaceous powder prepared by distillation under reduced pressure

    International Nuclear Information System (INIS)

    Mukohara, Susumu; Suzuki, Hiroshige

    1978-01-01

    It is attempted to produce high density, high strength and isotropic carbon made from carbonaceous powder. The carbonaceous powder was prepared by carbonization of coal-tar pitch at a temperature of 440 - 500 0 C and subsequent distillation under reduced pressure. The distillation was performed at a temperature of 300 - 500 0 C below the carbonization temperature. In some cases additional quinoline extraction was carried out on the powder. Green carbon body was formed without binder pitch under isostatic pressure at room temperature. The body was heat-treated at a temperature of 1100 - 2800 0 C. Bulk density, weight loss, shrinkage, strength, lattice parameter, crystallite size and BAF of the obtained carbon body were measured. It is confirmed that high density, high strength and isotropic carbon made from the carbonaceous powder and the following results were obtained. 1) BS (benzene soluble) fraction, β-resin (benzene insoluble and quinoline soluble) fraction and QI (quinoline insoluble) fraction were able to fractionate by distillation under reduced pressure. Concentration gradient of each fraction seems to exist in the carbonaceous powder. 2) Using the powder prepared by a lower temperature of the carbonization and/or the distillation, the carbon body had higher bulk density and higher strength. 3) The β-resin fraction had the effects of increasing the green density and enhancing the shrinkage of carbon body during the heat treatment. (author)

  12. Study on the Weaving Behavior of High Density Bidirectional Pedestrian Flow

    Directory of Open Access Journals (Sweden)

    Lishan Sun

    2014-01-01

    Full Text Available Weaving area may be the critical risk place in the subway transfer station. When improving service level of the weaving area, the characteristic of pedestrian weaving behavior should be systemically discussed. This paper described the mechanism of weaving behavior on high density pedestrian which was analyzed by the collection data of controlled experiment. Different weaving behaviors were contrasted due to different volumes in the bidirectional passageway. Video analysis was conducted to extract pedestrian moving behavior and calibrate the movement data with SIMI Motion. Influence of the high density weaving pedestrian was studied based on the statistical results (e.g., velocity, walking distance, and journey time. Furthermore, the quantitative method by speed analysis was announced to discriminate the conflict point. The scopes of weaving area and impact area at different pedestrian volumes were revealed to analyze the pedestrian turning angle. The paper concluded that walking pedestrians are significantly influenced by the weaving conflict and trend to turn the moving direction to avoid the conflict in weaving area; the ratio of stable weaving area and impact area is 2 to 3. The conclusions do provide a method to evaluate the transfer station safety and a facility layout guidance to improve the capacity.

  13. Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-high-density Electrochemical Sensing

    KAUST Repository

    Zhang, Jingjing

    2017-09-28

    In this paper, localized electrochemiluminescence (ECL) was visualized from nanoneedle electrodes that achieved very-high-density electrochemical sensing. The localized luminescence at the nanometer-sized tip observed was ascribed to enhanced mass transfer of the luminescence probe at the tip than on the planar surface surrounding the tip, which provided higher luminescence at the tip. The size of the luminescence spots was restricted to 15 μm permitting the electrochemical analysis with a density over 4 × 103 spots/mm2. The positive correlation between the luminescence intensity at the tips and the concentration of hydrogen peroxide supported the quantitative ECL analysis using nanoneedle electrodes. The further modification of glucose oxidase at the electrode surface conceptually demonstrated that the concentration of glucose ranging from 0.5 to 5 mM could be quantified using the luminescence at the tips, which could be further applied for the detection of multiple molecules in the complex biosystem. This successful localized ECL offers a specific strategy for the development of very-high-density electrochemical arrays without the complicated chip design.

  14. Optimization of Cold Spray Deposition of High-Density Polyethylene Powders

    Science.gov (United States)

    Bush, Trenton B.; Khalkhali, Zahra; Champagne, Victor; Schmidt, David P.; Rothstein, Jonathan P.

    2017-10-01

    When a solid, ductile particle impacts a substrate at sufficient velocity, the resulting heat, pressure and plastic deformation can produce bonding between the particle and the substrate. The use of a cool supersonic gas flow to accelerate these solid particles is known as cold spray deposition. The cold spray process has been commercialized for some metallic materials, but further research is required to unlock the exciting potential material properties possible with polymeric particles. In this work, a combined computational and experimental study was employed to study the cold spray deposition of high-density polyethylene powders over a wide range of particle temperatures and impact velocities. Cold spray deposition of polyethylene powders was demonstrated across a range broad range of substrate materials including several different polymer substrates with different moduli, glass and aluminum. A material-dependent window of successful deposition was determined for each substrate as a function of particle temperature and impact velocity. Additionally, a study of deposition efficiency revealed the optimal process parameters for high-density polyethylene powder deposition which yielded a deposition efficiency close to 10% and provided insights into the physical mechanics responsible for bonding while highlighting paths toward future process improvements.

  15. Passive fire protection in high density village (case study, Bustaman Semarang)

    Science.gov (United States)

    Sukawi, Sukawi; Wahyu Firmandhani, Satriya; Hardiman, Gagoek

    2017-12-01

    Fire hazard is the disaster that always has an unpredictable process of coming. When it comes, its level scope and the magnitude of the effects cannot be predicted. Dense settlements especially in big cities, among others Bustaman Kampong Semarang never escape from physical problems such as flooding and wildfire. If both are compared in dense settlements scope, so that, wild fire is the most potentially catastrophic. It is necessary to do a research on passive fire protection in a village of high density city such as Bustaman. Qualitative research was conducted using descriptive method to conduct observations and interviews in the Bustaman. Bustaman as a high density village, with narrow roads and dense rows of houses. The terraced buildings are also encountered, and found many buildings use combustible material. That environmental conditions can facilitate the propagation of flames in case of fire. To improve the established Bustaman's environment, in terms of the application of passive fire protection systems, it is recommended to utilize the road as the dividing buildings. Need to build the separation wall fireproof in every each series in several units of too long buildings and attempted open space procurement that separates rows of buildings that are too long, and also the replacement of combustible material with a material that is more incombustible.

  16. Essential elements of the high density H-mode on W7-AS

    International Nuclear Information System (INIS)

    McCormick, K.; Burhenn, R.; Grigull, P.

    2003-01-01

    The High Density H-Mode (HDH), discovered during the run-in phase of W7-AS divertor operation/1-3/, rapidly became the workhorse of the divertor program, combining optimal core behavior along with edge parameters necessary for successful operation of an Island Divertor. Its unique properties of high energy confinement along with low impurity retention and radiation localized at the edge under ELM-free steady-state conditions at high densities (to 4 x 10 20 m -3 ) and heating powers (to 1.7 MWm -3 ) make the HDH H-mode ideal for a reactor scenario, given it can be extended to higher temperatures in a larger machine. Hence, considerable effort has been invested to understand the nature of the HDH-mode in order to be able to extrapolate to next generation devices. To this end the present paper reports on experiments where two globally-similar ELM-free H-modes are compared: the classic quiescent H-mode H* where both impurity and density control are a severe problem and the HDH-mode with its contrasting steady-state behavior. Through modeling of the temporal behavior of laser-ablated aluminum spectral lines, as well as that of background impurities, it is concluded that a principle difference between the two H-modes is that of enhanced impurity diffusion in the edge gradient region of the HDH-mode. However, no direct indicators of enhanced diffusion have yet been identified. (orig.)

  17. High density event-related potential data acquisition in cognitive neuroscience.

    Science.gov (United States)

    Slotnick, Scott D

    2010-04-16

    Functional magnetic resonance imaging (fMRI) is currently the standard method of evaluating brain function in the field of Cognitive Neuroscience, in part because fMRI data acquisition and analysis techniques are readily available. Because fMRI has excellent spatial resolution but poor temporal resolution, this method can only be used to identify the spatial location of brain activity associated with a given cognitive process (and reveals virtually nothing about the time course of brain activity). By contrast, event-related potential (ERP) recording, a method that is used much less frequently than fMRI, has excellent temporal resolution and thus can track rapid temporal modulations in neural activity. Unfortunately, ERPs are under utilized in Cognitive Neuroscience because data acquisition techniques are not readily available and low density ERP recording has poor spatial resolution. In an effort to foster the increased use of ERPs in Cognitive Neuroscience, the present article details key techniques involved in high density ERP data acquisition. Critically, high density ERPs offer the promise of excellent temporal resolution and good spatial resolution (or excellent spatial resolution if coupled with fMRI), which is necessary to capture the spatial-temporal dynamics of human brain function.

  18. A compact fast ionization gauge for in situ measurement of high-density neutral flow dynamics

    Science.gov (United States)

    Weber, T. E.; Intrator, T. P.

    2014-04-01

    A compact ionization gauge has been developed to carry out in situ measurements of high density (1020-1022 m-3) neutral gas flow dynamics with high temporal and spatial resolution. Key design aspects are discussed including gauge sensitivity and time response scaling with decreased probe dimensions, high-pressure operation, improved driver circuit bandwidth, and techniques for constructing a miniaturized probe head. Gas adsorption was discovered to significantly alter emission current and gauge sensitivity over timescales of several seconds. This effect must be taken into consideration when making time-resolved, high-density measurements. Over short timescales gauge response was predicted by scaling the sensitivity of a nominal Bayard-Alpert gauge to account for variations in probe dimensions and species-dependent ionization cross-section. Time-resolved neutral density profiles have been acquired in the Magnetized Shock Experiment at Los Alamos National Laboratory, providing data on the initial conditions of the ionization, plasmoid formation, and translation processes. It is shown that the desired density profiles can be achieved using a dynamic gas fill and that density can be scaled independently of the spatial profile.

  19. Evolutionary Agroecology: the potential for cooperative, high density, weed-suppressing cereals.

    Science.gov (United States)

    Weiner, Jacob; Andersen, Sven B; Wille, Wibke K-M; Griepentrog, Hans W; Olsen, Jannie M

    2010-09-01

    Evolutionary theory can be applied to improve agricultural yields and/or sustainability, an approach we call Evolutionary Agroecology. The basic idea is that plant breeding is unlikely to improve attributes already favored by millions of years of natural selection, whereas there may be unutilized potential in selecting for attributes that increase total crop yield but reduce plants' individual fitness. In other words, plant breeding should be based on group selection. We explore this approach in relation to crop-weed competition, and argue that it should be possible to develop high density cereals that can utilize their initial size advantage over weeds to suppress them much better than under current practices, thus reducing or eliminating the need for chemical or mechanical weed control. We emphasize the role of density in applying group selection to crops: it is competition among individuals that generates the 'Tragedy of the Commons', providing opportunities to improve plant production by selecting for attributes that natural selection would not favor. When there is competition for light, natural selection of individuals favors a defensive strategy of 'shade avoidance', but a collective, offensive 'shading' strategy could increase weed suppression and yield in the high density, high uniformity cropping systems we envision.

  20. In situ neutron diffraction studies of high density amorphous ice under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Klotz, Stefan [Physique des Milieux Denses, IMPMC, CNRS UMR 7590, Universite P M Curie, 4 Place Jussieu, 75252 Paris (France); Straessle, Th [Physique des Milieux Denses, IMPMC, CNRS UMR 7590, Universite P M Curie, 4 Place Jussieu, 75252 Paris (France); Saitta, A M [Physique des Milieux Denses, IMPMC, CNRS UMR 7590, Universite P M Curie, 4 Place Jussieu, 75252 Paris (France); Rousse, G [Physique des Milieux Denses, IMPMC, CNRS UMR 7590, Universite P M Curie, 4 Place Jussieu, 75252 Paris (France); Hamel, G [Physique des Milieux Denses, IMPMC, CNRS UMR 7590, Universite P M Curie, 4 Place Jussieu, 75252 Paris (France); Nelmes, R J [School of Physics and Centre for Science at Extreme Conditions, University of Edinburgh, Edinburgh EH9 3JZ (United Kingdom); Loveday, J S [School of Physics and Centre for Science at Extreme Conditions, University of Edinburgh, Edinburgh EH9 3JZ (United Kingdom); Guthrie, M [School of Physics and Centre for Science at Extreme Conditions, University of Edinburgh, Edinburgh EH9 3JZ (United Kingdom)

    2005-03-23

    We review recent in situ neutron diffraction studies on the structural pressure dependence and the recrystallization of dense amorphous ices up to 2 GPa. Progress in high pressure techniques and data analysis methods allows the reliable determination of all three partial structure factors of amorphous ice under pressure. The strong pressure dependence of the g{sub OO}(r) correlation function shows that the isothermal compression of high density amorphous ice (HDA) at 100 K is achieved by a contraction ({approx} 20%) of the second-neighbour coordination shell leading to a strong increase in coordination. The g{sub DD}(r) and g{sub OD}(r) structure factors are, in contrast, only weakly sensitive to pressure. These data allow a comparison with structural features of the recently reported 'very high density amorphous ice' (VHDA) which indicates that VHDA at ambient pressure is very similar to compressed HDA, at least up to the second-neighbour shell. The recrystallization of HDA has been investigated in the range 0.3-2 GPa. It is shown that hydrogen-disordered phases are produced which normally grow only from the liquid, such as ice XII, and in particular ice IV. These findings are in good agreement with results on quench-recovered samples.

  1. High-density force myography: A possible alternative for upper-limb prosthetic control.

    Science.gov (United States)

    Radmand, Ashkan; Scheme, Erik; Englehart, Kevin

    2016-01-01

    Several multiple degree-of-freedom upper-limb prostheses that have the promise of highly dexterous control have recently been developed. Inadequate controllability, however, has limited adoption of these devices. Introducing more robust control methods will likely result in higher acceptance rates. This work investigates the suitability of using high-density force myography (HD-FMG) for prosthetic control. HD-FMG uses a high-density array of pressure sensors to detect changes in the pressure patterns between the residual limb and socket caused by the contraction of the forearm muscles. In this work, HD-FMG outperforms the standard electromyography (EMG)-based system in detecting different wrist and hand gestures. With the arm in a fixed, static position, eight hand and wrist motions were classified with 0.33% error using the HD-FMG technique. Comparatively, classification errors in the range of 2.2%-11.3% have been reported in the literature for multichannel EMG-based approaches. As with EMG, position variation in HD-FMG can introduce classification error, but incorporating position variation into the training protocol reduces this effect. Channel reduction was also applied to the HD-FMG technique to decrease the dimensionality of the problem as well as the size of the sensorized area. We found that with informed, symmetric channel reduction, classification error could be decreased to 0.02%.

  2. Alternative reproductive tactics and inverse size-assortment in a high-density fish spawning aggregation.

    Science.gov (United States)

    Karkarey, Rucha; Zambre, Amod; Isvaran, Kavita; Arthur, Rohan

    2017-02-28

    At high densities, terrestrial and marine species often employ alternate reproductive tactics (ARTs) to maximize reproductive benefits. We describe ARTs in a high-density and unfished spawning aggregation of the squaretail grouper (Plectropomus areolatus) in Lakshadweep, India. As previously reported for this species, territorial males engage in pair-courtship, which is associated with a pair-spawning tactic. Here, we document a previously unreported school-courtship tactic; where territorial males court multiple females in mid-water schools, which appears to culminate in a unique 'school-spawning' tactic. Courtship tactics were conditional on body size, local mate density and habitat, likely associated with changing trade-offs between potential mating opportunities and intra-sexual competition. Counter-intuitively, the aggregation showed a habitat-specific inverse size-assortment: large males courted small females on the reef slope while small males courted equal-sized or larger females on the shelf. These patterns remained stable across two years of observation at high, unfished densities. These unique density-dependent behaviours may disappear from this aggregation as overall densities decline due to increasing commercial fishing pressure, with potentially large consequences for demographics and fitness.

  3. Ignition relevant ablator response of boron carbide and high-density carbon driven by multiple shocks

    Science.gov (United States)

    Prisbrey, Shon T.; Baker, Kevin; Celliers, Peter; Dittrich, Tom; Moore, Alastair; Wu, Kuang Jen; Kervin, Peggy; Hurricane, Omar

    2013-10-01

    The attainment of self-propagating fusion burn in an inertial confinement target at the National Ignition Facility will require the use of an ablator with high rocket-efficiency and ablation pressure. The current ablation material, a glow-discharge polymer (GDP), does not couple as efficiently as simulations indicated to the multiple-shock inducing radiation drive environment created by laser power profile. In an effort to evaluate the performance of other possible ablators that could be suitable for achieving self-propagating fusion burn we have inferred the ablation performance of two possible ablators, boron carbide and high-density carbon, by measuring the shock speed of induced shocks while subjecting the ablators to a multiple-shock inducing radiation drive environment similar to a generic three-shock ignition drive. We present the platform used, velocity measurements used to infer the ablation response, and matching simulations to show the relative performance of boron carbide and high-density carbon with a general comparison to current performance of the currently used glow-discharge polymer ablator. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. Lawrence Livermore National Security, LLC. LLNL-ABS-640519.

  4. High-density biosynthetic fuels: the intersection of heterogeneous catalysis and metabolic engineering.

    Science.gov (United States)

    Harvey, Benjamin G; Meylemans, Heather A; Gough, Raina V; Quintana, Roxanne L; Garrison, Michael D; Bruno, Thomas J

    2014-05-28

    Biosynthetic valencene, premnaspirodiene, and natural caryophyllene were hydrogenated and evaluated as high performance fuels. The parent sesquiterpenes were then isomerized to complex mixtures of hydrocarbons with the heterogeneous acid catalyst Nafion SAC-13. High density fuels with net heats of combustion ranging from 133-141 000 Btu gal(-1), or up to 13% higher than commercial jet fuel could be generated by this approach. The products of caryophyllene isomerization were primarily tricyclic hydrocarbons which after hydrogenation increased the fuel density by 6%. The isomerization of valencene and premnaspirodiene also generated a variety of sesquiterpenes, but in both cases the dominant product was δ-selinene. Ab initio calculations were conducted to determine the total electronic energies for the reactants and products. In all cases the results were in excellent agreement with the experimental distribution of isomers. The cetane numbers for the sesquiterpane fuels ranged from 20-32 and were highly dependent on the isomer distribution. Specific distillation cuts may have the potential to act as high density diesel fuels, while use of these hydrocarbons as additives to jet fuel will increase the range and/or time of flight of aircraft. In addition to the ability to generate high performance renewable fuels, the powerful combination of metabolic engineering and heterogeneous catalysis will allow for the preparation of a variety of sesquiterpenes with potential for pharmaceutical, flavor, and fragrance applications.

  5. Simultaneous realization of high density edge transport barrier and improved L-mode on CHS

    International Nuclear Information System (INIS)

    Minami, Takashi; Okamura, Shoichi; Suzuki, Chihiro

    2008-10-01

    An edge transport barrier (ETB) formation and an improved L-mode (IL mode) have been simultaneously realized in high density region (n-bar e - 1.2x10 20 m -3 ) on Compact Helical System (CHS). When the ETB is formed during the IL mode, the density reduction in the edge region is suppressed by the barrier formation. As a result of the continuous increasing of the temperature by the IL mode, the stored energy during the combined mode increased up to the maximum stored energy (W p - 9.4 kJ) recorded in CHS experiments. The plasma pressure in the peripheral region increases up to three times larger than that of the L-mode, and the large edge plasma pressure gradient is formed accompanying the pedestal structure. That is caused by the anomalous transport reduction that is confirmed from the sharp drop of the density fluctuation in the edge region. The neutral particle reduction in the peripheral region and the metallic impurity accumulation in the core plasma are simultaneously observed during the high density ETB formation. (author)

  6. Investigations on the transport and metabolism of high density lipoprotein cholesteryl esters in African green monkeys

    International Nuclear Information System (INIS)

    Sorci-Thomas, M.G.

    1984-01-01

    The metabolic fate of circulating high density lipoprotein cholesteryl esters was studied in African green monkeys to determine the significance of the lipid transfer reaction on the catabolism of lipoprotein cholesteryl esters. A method of doubly labeling both moieties of lipoprotein cholesteryl esters with [ 3 He]cholesteryl oleate and cholesteryl [ 14 C]oleate was developed for the purpose of studying plasma cholesteryl ester metabolism in vivo. In these studies the total plasma [ 3 He]cholesterol turnover resulted in production rates, which ranged from 10-17 mg/kg day, similar to previously reported values in African green monkeys and in normal lipoproteinemic humans. In contrast to the production rates calculated from the decay of plasma 3 He-radioactivity, the production rates calculated from lipoproteins labeled with cholesteryl [ 14 C]oleate were approximately 2-3 times greater. In addition to these studies, a plasma cholesteryl ester transacylation activity was demonstrated in vitro when HDL containing doubly labeled cholesteryl esters were incubated with fresh plasma. These results demonstrated that high density lipoprotein cholesteryl esters undergo transacylation in vitro, resulting in release and reesterification of free [ 3 H]cholesterol

  7. Productivity assessment of three leguminous species under high-density plantations on degraded soil sites

    Energy Technology Data Exchange (ETDEWEB)

    Goel, V.L.; Behl, H.M. [National Botanical Research Institute, Lucknow (India). Biomass Biology Div.

    2004-11-01

    Performance of three leguminous species, (Acacia farnesiana, A. nilotica subspecies cupressiformis and Cassia siamea), was investigated at three planting densities (10,000, 20,000 and 30,000 plants ha{sup -1}) on a highly alkaline soil site (pH 8.6-10.5) in order to identify promising species and suitable plant spacing for optimum biomass harvest per unit area under shorter rotation harvests (3 year). The study revealed the differential behaviour of various species with respect to plant growth, survival and stand productivity in different population densities. Performance of A. farnesiana and C. siamea in terms of plant height, stem diameter and plant establishment was marginally affected by population density. Stand basal area (2.4-6.4 m{sup 2} ha{sup -1}) and biomass (4.45-13.5 t ha{sup -1}) in A. farnesiana increased markedly with increasing population density. Similar gains in biomass were observed in C. siamea when planted at higher densities. Individual tree biomass also was not affected by increasing plant densities, suggesting that these two species respond well to high-density plantation. A. nilotica subspecies cupressiformis, on the other hand, showed a negative response when planted in high density. Its biomass and basal area decreased beyond 20,000 plants ha{sup -1} planting density, suggesting that planting density of 20,000 plants ha{sup -1} and above were supra-optimal. Plants spaced at 10,000 plants ha{sup -1} showed faster growth rate and higher productivity as compared to the same at 20,000 and 30,000 planting density. Competition for space also effected individual tree growth in higher densities. The concept of high-density plantation is not applicable in A. nilotica subspecies cupressiformis. However, this species has significantly greater potential since it has relatively high biomass production even at a low population density of 10,000 plants ha{sup -1}. The study is useful in identifying productive species and optimum plantation density per

  8. High density lipoprotein cholesterol in relation to food consumption and running distance.

    Science.gov (United States)

    Hagan, R D; Smith, M G; Gettman, L R

    1983-03-01

    The effects of diet and exercise on serum triglycerides (Trig), total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and the HDL to TC ratio (HDL/TC) were evaluated in 45 men training continuously for a duration of 6 months. Body mass index (BMI), percentage body fat, and serum values for Trig, TC, HDL, and HDL/TC were constant throughout the observation period. Bivariate correlations indicated that Trig, TC, and LDL were linearly related and HDL and HDL/TC were related to HDL and HDL/TC. Multiple regression analysis suggested that BMI was the best predictor of Trig, TC, and LDL, while distance run per month was the best predictor of HDL and HDL/TC and second best predictor of Trig. The weekly intakes of fish, bread, cooked cereal, wine, beer, soft drinks, and vegetables were less significant predictors of lipoprotein levels.

  9. Behavior of a plasma in a high-density gas-embedded Z-pinch configuration

    International Nuclear Information System (INIS)

    Shlachter, J.S.

    1982-05-01

    The theoretical analysis of a high density Z-pinch (HDZP) begins with an examination of the steady state energy balance between ohmic heating and bremsstrahlung radiation losses for a plasma column in pressure equilibrium. The model is then expanded to include the time-varying internal energy and results in a quasi-equilibrium prescription for the load current through a constant radius plasma channel. This set of current waveforms is useful in the design of experimental systems. The behavior of a plasma for physically realizable conditions is first examined by allowing adiabatic changes in the column radius. A more complete model is then developed by incorporating inertial effects into the momentum equation, and the resultant global MHD computational model is compared with more sophisticated, and costly, one- and two-dimensional computer simulations. These comparisons demonstrate the advantages of the global MHD description over previously developed zero-dimensional models

  10. SERODS: a new medium for high-density optical data storage

    Science.gov (United States)

    Vo-Dinh, Tuan; Stokes, David L.

    1998-10-01

    A new optical dada storage technology based on the surface- enhanced Raman scattering (SERS) effect has been developed for high-density optical memory and three-dimensional data storage. With the surface-enhanced Raman optical data storage (SERODS) technology, the molecular interactions between the optical layer molecules and the nanostructured metal substrate are modified by the writing laser, changing their SERS properties to encode information as bits. Since the SERS properties are extremely sensitive to molecular nano- environments, very small 'spectrochemical holes' approaching the diffraction limit can be produced for the writing process. The SERODS device uses a reading laser to induce the SERS emission of molecules on the disk and a photometric detector tuned to the frequency of the RAMAN spectrum to retrieve the stored information. The results illustrate that SERODS is capable of three-dimensional data storage and has the potential to achieve higher storage density than currently available optical data storage systems.

  11. High-density EMG E-textile systems for the control of active prostheses.

    Science.gov (United States)

    Farina, Dario; Lorrain, Thomas; Negro, Francesco; Jiang, Ning

    2010-01-01

    Myoelectric control of active prostheses requires electrode systems that are easy to apply for daily repositioning of the electrodes by the user. In this study we propose the use of Smart Fabric and Interactive Textile (SFIT) systems as an alternative solution for recording high-density EMG signals for myoelectric control. A sleeve covering the upper and lower arm, which contains 100 electrodes arranged in four grids of 5 × 5 electrodes, was used to record EMG signals in 3 subjects during the execution of 9 tasks of the wrist and hand. The signals were analyzed by extracting wavelet coefficients which were classified with linear discriminant analysis. The average classification accuracy for the nine tasks was 89.1 ± 1.9 %. These results show that SFIT systems can be used as an effective way for muscle-machine interfacing.

  12. Conversion of Mixed Plastic Wastes (High Density Polyethylene and Polypropylene) into Liquid Fuel

    International Nuclear Information System (INIS)

    Chaw Su Su Hmwe; Tint Tint Kywe; Moe Moe Kyaw

    2010-12-01

    In this study, mixed plastic wastes were converted into liquid fuels. Mixed plastic wastes used were high density polyethylene (HDPE) and polypropylene (PP). The pyrolysis of mixed plastic waste to liquid fuel was carried out with and without prepared zeolite catalyst.The catalyst was characterized by X-ray Diffraction (XRD). This catalyst was pre-treated for activation. The experiments were carried out at temperature range of 350-410C.Physical properties (density, kinematic, viscosity,refractive index)of prepared liquid fuel samples were measured. From this study, yields of liquid fuel and gas fuel were found to be 41-64% and 15-35% respectively. As for by products, char was obtained as the yield percentages from 9 to 14% and wax (yield% - 1 to 14) was formed during pyrolysis.

  13. Bipolar one diode-one resistor integration for high-density resistive memory applications.

    Science.gov (United States)

    Li, Yingtao; Lv, Hangbing; Liu, Qi; Long, Shibing; Wang, Ming; Xie, Hongwei; Zhang, Kangwei; Huo, Zongliang; Liu, Ming

    2013-06-07

    Different from conventional unipolar-type 1D-1R RRAM devices, a bipolar-type 1D-1R memory device concept is proposed and successfully demonstrated by the integration of Ni/TiOx/Ti diode and Pt/HfO2/Cu bipolar RRAM cell to suppress the undesired sneak current in a cross-point array. The bipolar 1D-1R memory device not only achieves self-compliance resistive switching characteristics by the reverse bias current of the Ni/TiOx/Ti diode, but also exhibits excellent bipolar resistive switching characteristics such as uniform switching, satisfactory data retention, and excellent scalability, which give it high potentiality for high-density integrated nonvolatile memory applications.

  14. The Dynamic Mechanical Analysis of Highly Filled Rice Husk Biochar/High-Density Polyethylene Composites

    Directory of Open Access Journals (Sweden)

    Qingfa Zhang

    2017-11-01

    Full Text Available In this study, rice husk biochar/high-density polyethylene (HDPE composites were prepared via melt mixing followed by extrusion. Effects of biochar content and testing temperature on the dynamic mechanical analysis (DMA of the composites were studied. Morphological analysis of the rice husk biochar and composites were evaluated by scanning electron microscopy (SEM. The results showed that biochar had a positive effect on dynamic viscoelasticity, creep resistance and stress relaxation properties of the composites, but the creep resistance and stress relaxation of the composites decreased with the increase of temperature. SEM analysis showed that HDPE components were embedded in the holes of the rice husk biochar, and it is believed that strong interaction was achieved.

  15. Evidence of a high density population of harvested leopards in a montane environment.

    Science.gov (United States)

    Chase Grey, Julia N; Kent, Vivien T; Hill, Russell A

    2013-01-01

    Populations of large carnivores can persist in mountainous environments following extensive land use change and the conversion of suitable habitat for agriculture and human habitation in lower lying areas of their range. The significance of these populations is poorly understood, however, and little attention has focussed on why certain mountainous areas can hold high densities of large carnivores and what the conservation implications of such populations might be. Here we use the leopard (Panthera pardus) population in the western Soutpansberg Mountains, South Africa, as a model system and show that montane habitats can support high numbers of leopards. Spatially explicit capture-recapture (SECR) analysis recorded the highest density of leopards reported outside of state-protected areas in sub-Saharan Africa. This density represents a temporally high local abundance of leopards and we explore the explanations for this alongside some of the potential conservation implications.

  16. Evidence of a high density population of harvested leopards in a montane environment.

    Directory of Open Access Journals (Sweden)

    Julia N Chase Grey

    Full Text Available Populations of large carnivores can persist in mountainous environments following extensive land use change and the conversion of suitable habitat for agriculture and human habitation in lower lying areas of their range. The significance of these populations is poorly understood, however, and little attention has focussed on why certain mountainous areas can hold high densities of large carnivores and what the conservation implications of such populations might be. Here we use the leopard (Panthera pardus population in the western Soutpansberg Mountains, South Africa, as a model system and show that montane habitats can support high numbers of leopards. Spatially explicit capture-recapture (SECR analysis recorded the highest density of leopards reported outside of state-protected areas in sub-Saharan Africa. This density represents a temporally high local abundance of leopards and we explore the explanations for this alongside some of the potential conservation implications.

  17. Evolution of internal modes, disruptions and high-Z impurities at high density in pulsator

    International Nuclear Information System (INIS)

    Sesnic, S.

    1976-04-01

    The m = 1, n = 1 internal modes, the m = 0, n = 0 internal disruption and the development of high-Z impurities in high-density Tokamak discharges were investigated in the soft X-ray region. The increased density due to the fast gas input results in an increased relaxation period of the m = 0 disruption and increased modulation coefficient. The energy consideration for the internal disruption shows that only about one quarter of the ohmic heating power is lost through the electron channel. The measurements with Si surface barrier diodes, the measurements of Zeta (factor of the amount of the impurities in a hydrogen plasma) of molybdenum and stainless steel lines seem to indicate that the impurity profile is inverted with a minimum in the center. These measurements also indicate not only that the relative impurity content goes down during the fast gas input, but also that the impurities are possibly even expelled from the center of the discharge. (orig.) [de

  18. OSCAR experiment high-density network data report: Event 1 - April 8-9, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Dana, M.T.; Easter, R.C.; Thorp, J.M.

    1984-12-01

    The OSCAR (Oxidation and Scavenging Characteristics of April Rains) experiment, conducted during April 1981, was a cooperative field investigation of wet removal in cyclonic storm systems. The high-densiy component of OSCAR was located in northeast Indiana and included sequential precipitation chemistry measurements on a 100 by 100 km network, as well as airborne air chemistry and cloud chemistry measurements, surface air chemistry measurements, and supporting meteorological measurements. Four separate storm events were studied during the experiment. This report summarizes data taken by Pacific Northwest Laboratory (PNL) during the first storm event, April 8-9. The report contains the high-density network precipitation chemistry data, air chemistry data from the PNL aircraft, and meteorological data for the event, including standard National Weather Service products and radar data from the network. 4 references, 72 figures, 5 tables.

  19. Determination of Thermal Properties and Morphology of Eucalyptus Wood Residue Filled High Density Polyethylene Composites

    Directory of Open Access Journals (Sweden)

    Ayse Kabakci

    2008-02-01

    Full Text Available Thermal behaviors of eucalyptus wood residue (EWR filled recycled high density polyethylene (HDPE composites have been measured applying the thermogravimetric analysis (TGA and differential scanning calorimetry (DSC. Morphology of the materials was also studied using scanning electron microscope (SEM. Addition of the EWR into the recycled HDPE matrix reduced the starting of degradation temperature. EWR filled recycled HDPE had two main decomposition peaks, one for EWR around 350 °C and one for recycled HDPE around 460 °C. Addition of EWR did not affect the melting temperature of the recycled HDPE. Morphological study showed that addition of coupling agent improved the compatibility between wood residue and recycled HDPE.

  20. Development of nanocomposites employing high-density polyethylene and organo clay

    International Nuclear Information System (INIS)

    Lessa, Tathiane C. Rodrigues F.; Tavares, Maria Ines B.; Pita, Vitor J.R.R.

    2009-01-01

    The purpose of this study was to prepare nanocomposites of high-density polyethylene and montmorillonite organoclay by polymer melt intercalation, employing different processing parameters. Effective clay incorporation into polyethylene matrix was observed. The nanocomposites were structurally characterized. Intercalated nanocomposites were obtained from different process parameters, employing polyethylene resin and montmorillonite organoclays. The XRD results and other analysis showed that the processing parameters affect the organoclay delamination. The polyethylene nanocomposite presented the better performance using twin screw extruder, at 90 rpm. The purpose of characterization of polyethylene/organoclay nanocomposite by low-field NMR showed that this technique was important to understand changes in the molecular mobility of polyethylene when organoclay was incorporated. (author)

  1. Thermal Stability and Rheological Behaviors of High-Density Polyethylene/Fullerene Nanocomposites

    Directory of Open Access Journals (Sweden)

    Liping Zhao

    2012-01-01

    Full Text Available High-density polyethylene/fullerene (HDPE/C60 nanocomposites with the C60 loading that varied from 0.5 to 5.0% by weight were prepared via melt compounding. Thermogravimetric analysis (TGA and differential scanning calorimetry (DSC results showed that the presence of C60 could remarkably enhance the thermal properties of HDPE. A very low C60 loading (0.5 wt% increased the onset degradation temperature from 389∘C to 459∘C and decreased the heat release from 3176 J/g to 1490 J/g. The larger the loading level of C60, the better the thermal stability of HDPE/C60 nanocomposites. Rheological investigation results showed that the free radical trapping effect of C60 was responsible for the improved thermal stability of HDPE.

  2. Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity

    Science.gov (United States)

    2015-01-01

    We describe a strategy for rendering peptides resistant to proteolysis by formulating them as high-density brush polymers. The utility of this approach is demonstrated by polymerizing well-established cell-penetrating peptides (CPPs) and showing that the resulting polymers are not only resistant to proteolysis but also maintain their ability to enter cells. The scope of this design concept is explored by studying the proteolytic resistance of brush polymers composed of peptides that are substrates for either thrombin or a metalloprotease. Finally, we demonstrate that the proteolytic susceptibility of peptide brush polymers can be tuned by adjusting the density of the polymer brush and offer in silico models to rationalize this finding. We contend that this strategy offers a plausible method of preparing peptides for in vivo use, where rapid digestion by proteases has traditionally restricted their utility. PMID:25314576

  3. Preparation and characterisation of high-density ionic liquids incorporating halobismuthate anions.

    Science.gov (United States)

    Cousens, Nico E A; Taylor Kearney, Leah J; Clough, Matthew T; Lovelock, Kevin R J; Palgrave, Robert G; Perkin, Susan

    2014-07-28

    A range of ionic liquids containing dialkylimidazolium cations and halobismuthate anions ([BiBr(x)Cl(y)I(z)](-) and [Bi2Br(x)Cl(y)I(z)](-)) were synthesised by combining dialkylimidazolium halide ionic liquids with bismuth(III) halide salts. The majority were room temperature liquids, all with very high densities. The neat ionic liquids and their mixtures with 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide were characterised using Densitometry, Viscometry, NMR Spectroscopy, Electrospray Ionisation Mass Spectrometry (ESI), Liquid Secondary Ion Mass Spectrometry (LSIMS), Matrix-assisted Laser Desorption/Ionization Mass Spectrometry (MALDI), X-Ray Photoelectron Spectroscopy (XPS) and Thermogravimetric Analysis (TGA), to establish their speciation and suitability for high-temperature applications.

  4. Reaction between Steel-Making Slag and Carbonaceous Materials While Mixing with High Density Polyethylene

    Science.gov (United States)

    Hong, Lan; Sahajwalla, Veena

    2016-01-01

    Since the beginning of the extensive applications in numerous high temperature processes such as iron- and steel-making, coke-making etc. partly in the place of coke, the investigation into the reaction mechanism of waste plastics has become increasingly necessary. In this paper a fundamental study on the behavior of a typical component of waste plastics, high density polyethylene (HDPE), in a mixture with coke at a 1:1 ratio in mass base was conducted during the reaction with iron oxide in steel-making slag at 1823 K and was compared with coke and graphite. The reaction mechanism of carbonaceous materials was analyzed based on the contents of CO and CO2 in the off-gas monitored by an infrared (IR) gas analyzer. It is clear from the results that the reaction of HDPE and coke mixture with steel-making slag approached equilibrium of the Boudouard reaction more quickly and closely than coke or graphite.

  5. Characteristics of recycled and electron beam irradiated high density polyethylene samples

    International Nuclear Information System (INIS)

    Cardoso, Jessica R.; Gabriel, Leandro; Geraldo, Aurea B.C.; Moura, Eduardo

    2015-01-01

    Polymers modification by irradiation is a well-known process that allows degradation and cross-linking in concurrent events; this last is expected when an increase of mechanical properties is required. Actually, the interest of recycling and reuse of polymeric material is linked to the increase of plastics ending up in waste streams. Therefore, these both irradiation and recycling process may be conducted to allow a new use to this material that would be discarded by an improvement of its mechanical properties. In this work, the High Density Polyethylene (HDPE) matrix has been recycled five times from original substrate. The electron beam irradiation process was applied from 50 kGy to 200 kGy in both original and recycled samples; in this way, mechanical properties and thermal characteristics were evaluated. The results of applied process and material characterization are discussed. (author)

  6. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease

    Science.gov (United States)

    Kim, Daniel Seung; Marsillach, Judit; Furlong, Clement E; Jarvik, Gail P

    2014-01-01

    PON1 is a key component of high-density lipoproteins (HDLs) and is at least partially responsible for HDL's antioxidant/atheroprotective properties. PON1 is also associated with numerous human diseases, including cardiovascular disease, Parkinson's disease and cancer. In addition, PON1 metabolizes a broad variety of substrates, including toxic organophosphorous compounds, statin adducts, glucocorticoids, the likely atherogenic l-homocysteine thiolactone and the quorum-sensing factor of Pseudomonas aeruginosa. Numerous cardiovascular and antidiabetic pharmacologic agents, dietary macronutrients, lifestyle factors and antioxidant supplements affect PON1 expression and enzyme activity levels. Owing to the importance of PON1 to HDL function and its individual association with diverse human diseases, pharmacogenomic interactions between PON1 and the various factors that alter its expression and activity may represent an important therapeutic target for future investigation. PMID:24024900

  7. Mechanical Properties of Rice Husk Biochar Reinforced High Density Polyethylene Composites

    Directory of Open Access Journals (Sweden)

    Qingfa Zhang

    2018-03-01

    Full Text Available Rice husk biochar was utilized to reinforce high-density polyethylene (HDPE and to prepare biochar/plastic composites (BPC by the extrusion method. Morphologies, non-isothermal crystallization behavior, and mechanical properties of the composites were investigated. The SEM (scanning electron microscope showed that HDPE was embedded into the holes of the rice husk biochar. The DSC (differential scanning calorimeter showed that biochar could reduce the crystallization rate and the higher the content of rice husk biochar, the slower the crystallization rate. Significantly, the bending and tensile strength of BPC could reach 53.7 and 20 MPa, far beyond WPC (wood plastic composites. With the increase of filler content, BPC were still stronger than WPC, although the impact strength of BPC and WPC all showed a general decline in the trend. The strong interaction was achieved by the utilization of rice husk biochar to reinforce HDPE.

  8. Changes in mechanical properties due to gamma irradiation of high-density polyethylene (HDPE

    Directory of Open Access Journals (Sweden)

    S. S. Cota

    2007-06-01

    Full Text Available This paper presents an experimental analysis of the effect of dose and dose rate parameters during gamma irradiation of high-density polyethylene (HDPE samples. Considerations concerning the influence of these parameters on HDPE mechanical strength properties as a result of the predominance of oxidative degradation or of cross-linking are presented. The experimental results show an improvement of HDPE mechanical strength as dose increases, indicating the predominance of cross-linking over oxidative degradation and that lower doses are necessary to obtain a similar change in resistance parameters when radiation is applied at lower dose rates, showing that gamma radiation affects the HDPE in a more efficient way at lower dose rates.

  9. Development of low enrichment technologies for high density fuels and for isotope production targets

    International Nuclear Information System (INIS)

    Taboada, Horacio; Gonzalez, Alfredo G.

    2005-01-01

    Since more than twenty years ago, CNEA has carried out RERTR activities. Main goals are to convert the RA 6 reactor core from HEU to LEU, to get a comprehensive understanding of U-Mo/Al compounds phase formation in dispersed and monolithic fuels, to develop possible solutions to VHD dispersed and monolithic fuels technical problems, and to optimize techniques to recover U from silicide scrap samples. The future plans include: 1) Completion the RA 6 reactor conversion to LEU; 2) Qualification by irradiation of the promising solutions found for the high density fuels; 3) Irradiation of mini plates and full scale fuel assemblies at the RA 3 reactor and at higher flux and temperature reactors; 4) Optimization of LEU target and radiochemical techniques for radioisotope production. (author) [es

  10. Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins

    International Nuclear Information System (INIS)

    Klimov, A.N.; Popov, V.A.; Nagornev, V.A.; Pleskov, V.M.

    1985-01-01

    A study was made on the effect of high density lipoproteins (HDL) on the permeability of rabbit aorta to low density lipoproteins (LDL) after intravenous administration of human HDL and human ( 125 I)LDL to normal and hypercholesterolemic rabbits. Evaluation of radioactivity in plasma and aorta has shown that the administration of a large dose of HDL decreased the aorta permeability rate for ( 125 I)LDL on an average by 19% in normal rabbits, and by 45% in rabbits with moderate hypercholesterolemia. A historadiographic study showed that HDL also decreased the vessel wall permeability to ( 125 I)LDL in normal and particularly in hypercholesterolemic animals. The suggestion was made that HDL at very high molar concentration can hamper LDL transportation through the intact endothelial layer into the intima due to the ability of HDL to compete with LDL in sites of low affinity on the surface of endothelial cells. (author)

  11. A high density two-dimensional electron gas in an oxide heterostructure on Si (001)

    Energy Technology Data Exchange (ETDEWEB)

    Jin, E. N.; Kornblum, L.; Kumah, D. P.; Zou, K.; Walker, F. J. [Center for Research on Interface Structures and Phenomena and Department of Applied Physics, Yale University, New Haven, Connecticut 06511 (United States); Broadbridge, C. C. [Center for Research on Interface Structures and Phenomena and Department of Applied Physics, Yale University, New Haven, Connecticut 06511 (United States); Department of Physics, Southern Connecticut State University, 501 Crescent Street, New Haven, Connecticut 06515 (United States); Ngai, J. H. [Department of Physics, The University of Texas at Arlington, Arlington, Texas 76019 (United States); Ahn, C. H. [Center for Research on Interface Structures and Phenomena and Department of Applied Physics, Yale University, New Haven, Connecticut 06511 (United States); Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut 06511 (United States)

    2014-11-01

    We present the growth and characterization of layered heterostructures comprised of LaTiO{sub 3} and SrTiO{sub 3} epitaxially grown on Si (001). Magnetotransport measurements show that the sheet carrier densities of the heterostructures scale with the number of LaTiO{sub 3}/SrTiO{sub 3} interfaces, consistent with the presence of an interfacial 2-dimensional electron gas (2DEG) at each interface. Sheet carrier densities of 8.9 × 10{sup 14} cm{sup −2} per interface are observed. Integration of such high density oxide 2DEGs on silicon provides a bridge between the exceptional properties and functionalities of oxide 2DEGs and microelectronic technologies.

  12. Study of the photo-detection efficiency of FBK High-Density silicon photomultipliers

    International Nuclear Information System (INIS)

    Zappalà, G.; Regazzoni, V.; Acerbi, F.; Ferri, A.; Gola, A.; Paternoster, G.; Zorzi, N.; Piemonte, C.

    2016-01-01

    This work presents a study of the factors contributing to the Photo-Detection Efficiency of Silicon Photomultipliers (SiPMs): Quantum Efficiency, Triggering Probability and Fill Factor. Two different SiPM High-Density technologies are tested, NUV-HD, based on n-on-p junction, and RGB-HD, based on p-on-n junction, developed at FBK, Trento. The quantum efficiency was measured on photodiodes produced along with the SiPMs. The triggering probability, as a function of wavelength and bias voltage, was measured on circular Single Photon Avalanche Diodes (SPADs) with 100% fill factor. Square SPADs, having the same layout of single SiPM cells, were studied to measure the effective fill factor and compare it to the nominal value. The comparison of the circular and square SPADs allows to get the transition region size between the effective active area of the cell and the one defined by the layout.

  13. Production technology and properties of high-density items of aluminium nitride

    International Nuclear Information System (INIS)

    Poluboyarinov, D.N.; Gordova, M.R.; Kuznetsova, I.G.; Shalamova, I.P.; Silaev, V.A.

    1975-01-01

    The influence of grinding conditions (dry grinding, wet grinding, grinding with addition of surface active agents (SAA)) and of the duration of grinding on dispergation of aluminium nitride powder is studied. It is shown that an increase in the dispersity of the initial powder considerably enhances the density of fired articles. High-density ceramics from AlN can be produced from technical-purity powder ground to the specific surface of 10-13 m 2 /g, at a firing temperature of 1900-1950 deg C in a nitrogen atmosphere. The most important thermomechanical and electrophysical properties of ceramics produced from AlN are investigated and fields of application of such ceramics are determined

  14. Wood plastic composites based on microfibrillar blends of high density polyethylene/poly(ethylene terephthalate).

    Science.gov (United States)

    Lei, Yong; Wu, Qinglin

    2010-05-01

    High-melting-temperature poly(ethylene terephthalate) (PET) was successfully introduced into wood plastic composites through a two-step reactive extrusion technology. Wood flour was added into pre-prepared PET/high density polyethylene (HDPE) microfibrillar blends (MFBs) in the second extrusion at the temperature for processing HDPE. Addition of 25% in situ formed PET microfibers obviously increased the mechanical properties of HDPE, and more significant enhancement by the in situ formed recycled PET microfibers was observed for the recycled HDPE. Adding 2% E-GMA improved the compatibility between matrix and microfibers in MFBs, resulting further enhanced mechanical properties. The subsequent addition of 40% wood flour did not influence the size and morphology of PET microfibers, and improved the comprehensive mechanical properties of MFBs. The wood flour increased the crystallinity level of HDPE in the compatibilized MFB in which PET phase did not crystallize. The storage modulus of MFB was greatly improved by wood flour. Published by Elsevier Ltd.

  15. Neutrino flavor conversions in high-density astrophysical and cosmological environments

    International Nuclear Information System (INIS)

    Saviano, Ninetta

    2014-03-01

    The topic of this thesis is the study of the neutrino flavor conversions in high-density environments: the supernovae and the the Early Universe. Remarkably, these represent the only two cases in which neutrinos themselves contribute to the ''background medium'' for their propagation, making their oscillations a non-linear phenomenon. In particular, in the dense supernova core, the neutrino-neutrino interactions can lead in some situations to surprising and counterintuitive collective phenomena, when the entire neutrino system oscillates coherently as a single collective mode. In this context, we have shown that during the early SN accretion phase (post-bounce times 10 -3 ) in order to suppress the sterile neutrino production and to find a better agreement between the cosmological and laboratory hints. Finally, we discuss the implications of our results on Big-Bang Nucleosynthesis and on the Cosmic Microwave Background from data measured by the Planck experiment.

  16. Impact of a high density GPS network on the operational forecast

    Directory of Open Access Journals (Sweden)

    C. Faccani

    2005-01-01

    Full Text Available Global Positioning System Zenith Total Delay (GPS ZTD can provide information about the water vapour in atmosphere. Its assimilation into the analysis used to initialize a model can then improve the weather forecast, giving the right amount of moisture and reducing the model spinup. In the last year, an high density GPS network has been created on the Basilicata region (south of Italy by the Italian Space Agency in the framework of a national project named MAGIC2. MAGIC2 is the Italian follow on of the EC project MAGIC has. Daily operational data assimilation experiments are performed since December 2003. The results show that the assimilation of GPS ZTD improves the forecast especially during the transition from winter to spring even if a no very high model resolution (9km is used.

  17. Dynamic Nuclear Polarization of High-Density Atomic Hydrogen in Solid Mixtures of Molecular Hydrogen Isotopes

    Science.gov (United States)

    Sheludiakov, S.; Ahokas, J.; Järvinen, J.; Zvezdov, D.; Vainio, O.; Lehtonen, L.; Vasiliev, S.; Mao, S.; Khmelenko, V. V.; Lee, D. M.

    2014-12-01

    We report on magnetic resonance studies of high-density atomic hydrogen and deuterium in solid hydrogen matrices at temperatures below 1 K. Average concentrations of H atoms ≈3 ×1019 cm-3 are obtained in chemical tunneling reactions of isotope exchange with D atoms. The products of these reactions are closely located pairs of H atoms near D2 molecules with strong exchange interactions. We discovered a dynamic nuclear polarization effect on H atoms created by pumping the center of the H electron spin resonance spectrum, similar to the Overhauser effect in metals. Our results indicate that H atoms may be arranged inside molecular matrices at separations equivalent to local concentrations of 2.6 ×1021 cm-3 . This opens up a way to build a metallic state of atomic hydrogen at zero pressure.

  18. Immunohistochemical detection of a very high density lipoprotein (VHDL) in ovarian follicles of Triatoma infestans.

    Science.gov (United States)

    González, M S; Ronderos, J R; Rimoldi, O J; Brenner, R R

    2001-04-01

    The ability of Triatoma infestans ovarian follicles to synthesize a very high-density lipoprotein (VHDL) has been examined by immunohistochemical methods. This kind of lipoprotein can be envisaged as a storage hexameric protein present in the hemolymph of some insect species. VHDL immunoreactivity is observed in oocytes at different stages of maturation. The antigen is present in the oocyte cytoplasm as well as in the follicular epithelial cells. The immunopositive reaction in the apical surface of follicle cells suggests both a VHDL synthesis and a secretion process. Furthermore, VHDL seems to be stored into oocyte in yolk granules. On the contrary, no immunopositive reaction is observed in the intracellular spaces between follicle cells, suggesting that VHDL is not incorporated from hemolymph into the oocyte.

  19. Photoneutron and capture gamma dose calculations for a radiotherapy room made of high density concrete

    Directory of Open Access Journals (Sweden)

    Mesbahi Asghar

    2011-01-01

    Full Text Available Neutron and capture gamma ray dose equivalent along the maze and entrance door of a radiation therapy room made of high density concrete was calculated using analytical and Monte Carlo methods. The room geometry and the 18 MV photon beam of a Varian 2100C/D linac were simulated using MCNPX MC code. Four analytical methods including Kersey, French, McCall, and Wu-McGinley methods were used in the current study. Average difference of 13-30% was seen between analytical and MC methods along the maze for photoneutron calculations. The difference between Wu-McGinley and MC methods was about 17% for capture gamma ray calculations. It was concluded that the analytical methods overestimate both neutron and capture gamma ray dose equivalents compared to MC. Moreover, it was shown that the analytical methods can be used as conservative estimators for neutron and capture gamma calculations.

  20. Ultra-High Density Electron Beams for Beam Radiation and Beam Plasma Interaction

    CERN Document Server

    Anderson, Scott; Frigola, Pedro; Gibson, David J; Hartemann, Fred V; Jacob, Jeremy S; Lim, Jae; Musumeci, Pietro; Rosenzweig, James E; Travish, Gil; Tremaine, Aaron M

    2005-01-01

    Current and future applications of high brightness electron beams, which include advanced accelerators such as the plasma wake-field accelerator (PWFA) and beam-radiation interactions such as inverse-Compton scattering (ICS), require both transverse and longitudinal beam sizes on the order of tens of microns. Ultra-high density beams may be produced at moderate energy (50 MeV) by compression and subsequent strong focusing of low emittance, photoinjector sources. We describe the implementation of this method used at LLNL's PLEIADES ICS x-ray source in which the photoinjector-generated beam has been compressed to 300 fsec duration using the velocity bunching technique and focused to 20 μm rms size using an extremely high gradient, permanent magnet quadrupole (PMQ) focusing system.

  1. High Density Hydrogen Storage System Demonstration Using NaAlH4 Based Complex Compound Hydrides

    Energy Technology Data Exchange (ETDEWEB)

    Daniel A. Mosher; Xia Tang; Ronald J. Brown; Sarah Arsenault; Salvatore Saitta; Bruce L. Laube; Robert H. Dold; Donald L. Anton

    2007-07-27

    This final report describes the motivations, activities and results of the hydrogen storage independent project "High Density Hydrogen Storage System Demonstration Using NaAlH4 Based Complex Compound Hydrides" performed by the United Technologies Research Center under the Department of Energy Hydrogen Program, contract # DE-FC36-02AL67610. The objectives of the project were to identify and address the key systems technologies associated with applying complex hydride materials, particularly ones which differ from those for conventional metal hydride based storage. This involved the design, fabrication and testing of two prototype systems based on the hydrogen storage material NaAlH4. Safety testing, catalysis studies, heat exchanger optimization, reaction kinetics modeling, thermochemical finite element analysis, powder densification development and material neutralization were elements included in the effort.

  2. High Density Radiation Shielding Concretes for Hot Cells of 99mTc Project

    International Nuclear Information System (INIS)

    Sakr, K.

    2006-01-01

    High density concrete [more than 3.6 ton/m 3 (3.6x10 3 kg/m 3 )] was prepared to be used as a radiation shielding concrete (RSC) for hot-cells in gel technetium project at inshas to attenuate gamma radiation emitted from radioactive sources. different types of concrete were prepared by mixing local mineral aggregates mainly gravel and ilmenite . iron shots were added to the concrete mixture proportion as partial replacement of heavy aggregates to increase its density. the physical properties of prepared concrete in both plastic and hardened phases were investigated. compressive strength and radiation attenuation of gamma rays were determined. Results showed that ilmenite concrete mixed with iron shots had the highest density suitable to be use as RSC according to the chinese hot cell design requirements. Recommendations to avoid some technical problems of manufacturing radiation shielding concrete were maintained

  3. Thermal properties of silica-filled high density polyethylene composites compatibilized with glut palmitate

    Science.gov (United States)

    Samsudin, Dalina; Ismail, Hanafi; Othman, Nadras; Hamid, Zuratul Ain Abdul

    2017-07-01

    A study of thermal properties resulting from the utilization of Glut Palmitate (GP) on the silica filled high density polyethylene (HDPE) composites was carried out. The composites with the incorporation of GP at 0.5, 1.0, 2.0 and 3.0 phr were prepared by using an internal mixer at the temperature 180 °C and the rotor speed of 50 rpm. The thermal behaviours of the composites were then investigated using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). It was found that the crystallinity and the thermal stability of the composites increased with the incorporation of GP. The highest crystallinity contents and decomposition temperatures were observed at the 1 phr GP loading.

  4. Nanopattern transfer from high-density self-assembled nanosphere arrays on prepatterned substrates

    Science.gov (United States)

    Oshima, Hirotaka; Tamura, Hiroaki; Takeuchi, Mitsuo; Inomata, Akihiro; Yanagida, Yoshiaki; Matsushita, Naohisa; Komoriya, Hitoshi; Uzumaki, Takuya; Tanaka, Atsushi

    2009-11-01

    We have fabricated nanoimprint moulds with high-density well-defined nanopatterns by pattern transfer from self-assembled nanosphere arrays on prepatterned substrates. Silica nanospheres of 100 and 25 nm diameter were regularly arranged over large areas in a self-assembling manner by capillary force via a dip-coating technique on topographically patterned substrates having 220 nm pitch line/space patterns. The nanosphere arrays were used as etching masks, and nanodot arrays with the same arrangements were created on the silica substrate surfaces by reactive ion etching (RIE). By developing a combined pattern transfer process using Ru and SiOx mask layers and CF4 and O2 RIE, the aspect ratio between the height and diameter of the nanodots made from the 25 nm nanospheres is improved to about two. It is demonstrated that the nanopatterns of the moulds can be inversely transferred into polymer surfaces reproducibly by UV nanoimprint process.

  5. A High-Density Map for Navigating the Human Polycomb Complexome

    Directory of Open Access Journals (Sweden)

    Simon Hauri

    2016-10-01

    Full Text Available Polycomb group (PcG proteins are major determinants of gene silencing and epigenetic memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome using a robust affinity purification mass spectrometry approach. Our high-density protein interaction network uncovered a diverse range of PcG complexes. Moreover, our analysis identified PcG interactors linking them to the PcG system, thus providing insight into the molecular function of PcG complexes and mechanisms of recruitment to target genes. We identified two human PRC2 complexes and two PR-DUB deubiquitination complexes, which contain the O-linked N-acetylglucosamine transferase OGT1 and several transcription factors. Finally, genome-wide profiling of PR-DUB components indicated that the human PR-DUB and PRC1 complexes bind distinct sets of target genes, suggesting differential impact on cellular processes in mammals.

  6. Process for obtaining sintered conglomerates with a high density of rare earth oxides and actinides

    International Nuclear Information System (INIS)

    Pasto, A.E.

    1974-01-01

    The invention concerns a method to produce agglomerates of actinide and rare earth oxides possessing a cubic-monoclinic transformation in order to obtain high densities close to the theoretical density, and the articles produced by the method. The process is based on the use of a rare earth or actinide oxide, in particular Eu 2 O 3 , with a cubic-monoclinic phase transformation, the oxide being sintered by hot compression at a temperature 50 deg C to 100 deg C above the transformation temperature. The sintered agglomerates obtained can have a purity of at least 99.9% and a density of practically 100%. These agglomerates are suitable in particular for the formation of nuclear reactor control rods [fr

  7. Radiation Tests of Highly Scaled, High-Density, Commercial, Nonvolatile NAND Flash Memories - Update 2012

    Science.gov (United States)

    Irom, Farokh; Allen, Gregory R.

    2012-01-01

    The space radiation environment poses a certain risk to all electronic components on Earth-orbiting and planetary mission spacecraft. In recent years, there has been increased interest in the use of high-density, commercial, nonvolatile flash memories in space because of ever-increasing data volumes and strict power requirements. They are used in a wide variety of spacecraft subsystems. At one end of the spectrum, flash memories are used to store small amounts of mission-critical data such as boot code or configuration files and, at the other end, they are used to construct multi-gigabyte data recorders that record mission science data. This report examines single-event effect (SEE) and total ionizing dose (TID) response in single-level cell (SLC) 32-Gb, multi-level cell (MLC) 64-Gb, and Triple-level (TLC) 64-Gb NAND flash memories manufactured by Micron Technology with feature size of 25 nm.

  8. High-Density Signal Interface Electromagnetic Radiation Prediction for Electromagnetic Compatibility Evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Halligan, Matthew

    2017-11-01

    Radiated power calculation approaches for practical scenarios of incomplete high- density interface characterization information and incomplete incident power information are presented. The suggested approaches build upon a method that characterizes power losses through the definition of power loss constant matrices. Potential radiated power estimates include using total power loss information, partial radiated power loss information, worst case analysis, and statistical bounding analysis. A method is also proposed to calculate radiated power when incident power information is not fully known for non-periodic signals at the interface. Incident data signals are modeled from a two-state Markov chain where bit state probabilities are derived. The total spectrum for windowed signals is postulated as the superposition of spectra from individual pulses in a data sequence. Statistical bounding methods are proposed as a basis for the radiated power calculation due to the statistical calculation complexity to find a radiated power probability density function.

  9. Symmetry and illumination uniformity requirements for high density laser-driven implosions

    International Nuclear Information System (INIS)

    Mead, W.C.; Lindl, J.D.

    1976-01-01

    As laser capabilities increase, implosions will be performed to achieve high densities. Criteria are discussed for formation of a low-density corona, preheated supersonically, which increases the tolerance of high convergence implosions to non-uniform illumination by utilizing thermal smoothing. We compare optimized double shell target designs without and with atmosphere production. Two significant penalties are incurred with atmosphere production using 1 μm laser light. First, a large initial shock at the ablation surface limits the pulse shaping flexibility, and degrades implosion performance. Second, the mass and heat capacity of the atmosphere reduce the energy delivered to the ablation surface and the driving pressures obtained for a given input energy. Improvement is possible using 2 μm light for the initial phase of the implosion. We present results of 2-D simulations which evaluate combined symmetry and stability requirements. At l = 8, the improvement produced in the example is a factor of 10, giving tolerance of 10 percent

  10. Method and device for secure, high-density tritium bonded with carbon

    Science.gov (United States)

    Wertsching, Alan Kevin; Trantor, Troy Joseph; Ebner, Matthias Anthony; Norby, Brad Curtis

    2016-04-05

    A method and device for producing secure, high-density tritium bonded with carbon. A substrate comprising carbon is provided. A precursor is intercalated between carbon in the substrate. The precursor intercalated in the substrate is irradiated until at least a portion of the precursor, preferably a majority of the precursor, is transmutated into tritium and bonds with carbon of the substrate forming bonded tritium. The resulting bonded tritium, tritium bonded with carbon, produces electrons via beta decay. The substrate is preferably a substrate from the list of substrates consisting of highly-ordered pyrolytic graphite, carbon fibers, carbon nanotunes, buckministerfullerenes, and combinations thereof. The precursor is preferably boron-10, more preferably lithium-6. Preferably, thermal neutrons are used to irradiate the precursor. The resulting bonded tritium is preferably used to generate electricity either directly or indirectly.

  11. Is the bulk mode conversion important in high density helicon plasma?

    International Nuclear Information System (INIS)

    Isayama, Shogo; Hada, Tohru; Shinohara, Shunjiro; Tanikawa, Takao

    2016-01-01

    In a high-density helicon plasma production process, a contribution of Trivelpiece-Gould (TG) wave for surface power deposition is widely accepted. The TG wave can be excited either due to an abrupt density gradient near the plasma edge (surface conversion) or due to linear mode conversion from the helicon wave in a density gradient in the bulk region (bulk mode conversion). By numerically solving the boundary value problem of linear coupling between the helicon and the TG waves in a background with density gradient, we show that the efficiency of the bulk mode conversion strongly depends on the dissipation included in the plasma, and the bulk mode conversion is important when the dissipation is small. Also, by performing FDTD simulation, we show the time evolution of energy flux associated with the helicon and the TG waves.

  12. Enhancement of high density polyethylene high integrity containers at a low level radioactive waste disposal site

    International Nuclear Information System (INIS)

    Sauer, R.E.; Wong, O.P.

    1989-01-01

    High integrity containers (HIC) made of high density polyethylene (HDPE) have been used for disposal in South Carolina since the late seventies. With the recent definitive position taken by the NRC on the suitability of these containers for disposal, alternative means of assuring the structural integrity of the containers for the long term became necessary. The authors' company has developed an utilized reinforced concrete caissons at the Hanford, Washington site as an additional barrier and structural element to assure the long term high integrity function of the current HDPE HIC's also known as Poly HIC's on the market. This paper outlines the background of the HIC's in question, the NRC positions and ruling, and presents technical bases for the applicability of appropriately designed concrete overpacks to augment the structural integrity of HIC's

  13. Preparation and characterization of high density polyethylene and residual fibre of Attalea funifera Mart (piacava) composites

    International Nuclear Information System (INIS)

    Agrela, Sara P.; Guimaraes, Danilo H.; Jose, Nadia M.; Carvalho, Gleidson G.P.; Carvalho, Ricardo F.

    2009-01-01

    The use of natural fiber reinforcement thermoplastic polymer is continuously increasing. This fact is manly due to its advantages as low cost, availability, recyclability, low energy demand and then environmental appeal if compared to synthetics fibers. The composites were prepared in different fiber volume ratios (5%, 10% and 20%) mixed with high density polyethylene (HDPE) and heated at 190 deg C. Thermogravimetric analysis and differential scanning calorimetry were used to investigate thermal stability. The composites structure was characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry. Fiber and residue of piassava (Attalea funifera Mart) chemical composition were determined by Van Soest Method. The results indicate that thermo stability of the composites of HDPE prepared with fiber volume ratios up to 20% is only slightly lowered. (author)

  14. High Current, High Density Arc Plasma as a New Source for WiPAL

    Science.gov (United States)

    Waleffe, Roger; Endrizzi, Doug; Myers, Rachel; Wallace, John; Clark, Mike; Forest, Cary; WiPAL Team

    2016-10-01

    The Wisconsin Plasma Astrophysics Lab (WiPAL) has installed a new array of nineteen plasma sources (plasma guns) on its 3 m diameter, spherical vacuum vessel. Each gun is a cylindrical, molybdenum, washer-stabilized, arc plasma source. During discharge, the guns are maintained at 1.2 kA across 100 V for 10 ms by the gun power supply establishing a high density plasma. Each plasma source is fired independently allowing for adjustable plasma parameters, with densities varying between 1018 -1019 m-3 and electron temperatures of 5-15 eV. Measurements were characterized using a 16 tip Langmuir probe. The plasma source will be used as a background plasma for the magnetized coaxial plasma gun (MCPG), the Terrestrial Reconnection Experiment (TREX), and as the plasma source for a magnetic mirror experiment. Temperature, density, and confinement results will be presented. This work is supported by the DoE and the NSF.

  15. Development and validation of a high density SNP genotyping array for Atlantic salmon (Salmo salar).

    Science.gov (United States)

    Houston, Ross D; Taggart, John B; Cézard, Timothé; Bekaert, Michaël; Lowe, Natalie R; Downing, Alison; Talbot, Richard; Bishop, Stephen C; Archibald, Alan L; Bron, James E; Penman, David J; Davassi, Alessandro; Brew, Fiona; Tinch, Alan E; Gharbi, Karim; Hamilton, Alastair

    2014-02-06

    Dense single nucleotide polymorphism (SNP) genotyping arrays provide extensive information on polymorphic variation across the genome of species of interest. Such information can be used in studies of the genetic architecture of quantitative traits and to improve the accuracy of selection in breeding programs. In Atlantic salmon (Salmo salar), these goals are currently hampered by the lack of a high-density SNP genotyping platform. Therefore, the aim of the study was to develop and test a dense Atlantic salmon SNP array. SNP discovery was performed using extensive deep sequencing of Reduced Representation (RR-Seq), Restriction site-Associated DNA (RAD-Seq) and mRNA (RNA-Seq) libraries derived from farmed and wild Atlantic salmon samples (n = 283) resulting in the discovery of > 400 K putative SNPs. An Affymetrix Axiom® myDesign Custom Array was created and tested on samples of animals of wild and farmed origin (n = 96) revealing a total of 132,033 polymorphic SNPs with high call rate, good cluster separation on the array and stable Mendelian inheritance in our sample. At least 38% of these SNPs are from transcribed genomic regions and therefore more likely to include functional variants. Linkage analysis utilising the lack of male recombination in salmonids allowed the mapping of 40,214 SNPs distributed across all 29 pairs of chromosomes, highlighting the extensive genome-wide coverage of the SNPs. An identity-by-state clustering analysis revealed that the array can clearly distinguish between fish of different origins, within and between farmed and wild populations. Finally, Y-chromosome-specific probes included on the array provide an accurate molecular genetic test for sex. This manuscript describes the first high-density SNP genotyping array for Atlantic salmon. This array will be publicly available and is likely to be used as a platform for high-resolution genetics research into traits of evolutionary and economic importance in salmonids and in aquaculture

  16. Development and characterization of a high density SNP genotyping assay for cattle.

    Directory of Open Access Journals (Sweden)

    Lakshmi K Matukumalli

    Full Text Available The success of genome-wide association (GWA studies for the detection of sequence variation affecting complex traits in human has spurred interest in the use of large-scale high-density single nucleotide polymorphism (SNP genotyping for the identification of quantitative trait loci (QTL and for marker-assisted selection in model and agricultural species. A cost-effective and efficient approach for the development of a custom genotyping assay interrogating 54,001 SNP loci to support GWA applications in cattle is described. A novel algorithm for achieving a compressed inter-marker interval distribution proved remarkably successful, with median interval of 37 kb and maximum predicted gap of <350 kb. The assay was tested on a panel of 576 animals from 21 cattle breeds and six outgroup species and revealed that from 39,765 to 46,492 SNP are polymorphic within individual breeds (average minor allele frequency (MAF ranging from 0.24 to 0.27. The assay also identified 79 putative copy number variants in cattle. Utility for GWA was demonstrated by localizing known variation for coat color and the presence/absence of horns to their correct genomic locations. The combination of SNP selection and the novel spacing algorithm allows an efficient approach for the development of high-density genotyping platforms in species having full or even moderate quality draft sequence. Aspects of the approach can be exploited in species which lack an available genome sequence. The BovineSNP50 assay described here is commercially available from Illumina and provides a robust platform for mapping disease genes and QTL in cattle.

  17. Growth of High-Density Zinc Oxide Nanorods on Porous Silicon by Thermal Evaporation

    Directory of Open Access Journals (Sweden)

    Nurul Izni Rusli

    2012-12-01

    Full Text Available The formation of high-density zinc oxide (ZnO nanorods on porous silicon (PS substrates at growth temperatures of 600–1000 °C by a simple thermal evaporation of zinc (Zn powder in the presence of oxygen (O2 gas was systematically investigated. The high-density growth of ZnO nanorods with (0002 orientation over a large area was attributed to the rough surface of PS, which provides appropriate planes to promote deposition of Zn or ZnOx seeds as nucleation sites for the subsequent growth of ZnO nanorods. The geometrical morphologies of ZnO nanorods are determined by the ZnOx seed structures, i.e., cluster or layer structures. The flower-like hexagonal-faceted ZnO nanorods grown at 600 °C seem to be generated from the sparsely distributed ZnOx nanoclusters. Vertically aligned hexagonal-faceted ZnO nanorods grown at 800 °C may be inferred from the formation of dense arrays of ZnOx clusters. The formation of disordered ZnO nanorods formed at 1000 °C may due to the formation of a ZnOx seed layer. The growth mechanism involved has been described by a combination of self-catalyzed vapor-liquid-solid (VLS and vapor-solid (VS mechanism. The results suggest that for a more precise study on the growth of ZnO nanostructures involving the introduction of seeds, the initial seed structures must be taken into account given their significant effects.

  18. A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities.

    Science.gov (United States)

    Price, Jacob R; Shieh, Wen K; Sales, Christopher M

    2015-12-25

    A novel reactor design, coined a high density bioreactor (HDBR), is presented for the cultivation and study of high density microbial communities. Past studies have evaluated the performance of the reactor for the removal of COD(1) and nitrogen species(2-4) by heterotrophic and chemoautotrophic bacteria, respectively. The HDBR design eliminates the requirement for external flocculation/sedimentation processes while still yielding effluent containing low suspended solids. In this study, the HDBR is applied as a photobioreactor (PBR) in order to characterize the nitrogen removal characteristics of an algae-based photosynthetic microbial community. As previously reported for this HDBR design, a stable biomass zone was established with a clear delineation between the biologically active portion of the reactor and the recycling reactor fluid, which resulted in a low suspended solid effluent. The algal community in the HDBR was observed to remove 18.4% of total nitrogen species in the influent. Varying NH4(+) and NO3(-) concentrations in the feed did not have an effect on NH4(+) removal (n=44, p=0.993 and n=44, p=0.610 respectively) while NH4(+) feed concentration was found to be negatively related with NO3(-) removal (n=44, p=0.000) and NO3(-) feed concentration was found to be positively correlated with NO3(-) removal (n=44, p=0.000). Consistent removal of NH4(+), combined with the accumulation of oxidized nitrogen species at high NH4(+) fluxes indicates the presence of ammonia- and nitrite-oxidizing bacteria within the microbial community.

  19. Comparison of different imputation methods from low- to high-density panels using Chinese Holstein cattle.

    Science.gov (United States)

    Weng, Z; Zhang, Z; Zhang, Q; Fu, W; He, S; Ding, X

    2013-05-01

    Imputation of high-density genotypes from low- or medium-density platforms is a promising way to enhance the efficiency of whole-genome selection programs at low cost. In this study, we compared the efficiency of three widely used imputation algorithms (fastPHASE, BEAGLE and findhap) using Chinese Holstein cattle with Illumina BovineSNP50 genotypes. A total of 2108 cattle were randomly divided into a reference population and a test population to evaluate the influence of the reference population size. Three bovine chromosomes, BTA1, 16 and 28, were used to represent large, medium and small chromosome size, respectively. We simulated different scenarios by randomly masking 20%, 40%, 80% and 95% single-nucleotide polymorphisms (SNPs) on each chromosome in the test population to mimic different SNP density panels. Illumina Bovine3K and Illumina BovineLD (6909 SNPs) information was also used. We found that the three methods showed comparable accuracy when the proportion of masked SNPs was low. However, the difference became larger when more SNPs were masked. BEAGLE performed the best and was most robust with imputation accuracies >90% in almost all situations. fastPHASE was affected by the proportion of masked SNPs, especially when the masked SNP rate was high. findhap ran the fastest, whereas its accuracies were lower than those of BEAGLE but higher than those of fastPHASE. In addition, enlarging the reference population improved the imputation accuracy for BEAGLE and findhap, but did not affect fastPHASE. Considering imputation accuracy and computational requirements, BEAGLE has been found to be more reliable for imputing genotypes from low- to high-density genotyping platforms.

  20. Qualification of high density aluminide fuels for the BR2 reactor

    International Nuclear Information System (INIS)

    Beeckmans de West-Meerbeeck, Andre; Gubel, Pol; Ponsard, Bernard; Pin, Thomas; Falgoux, Jean Louis

    2005-01-01

    The BR2 operation still relies on the use of 90..93% enriched HEU aluminide fuel. The availability of a limited batch of 73% enriched HEU from reprocessed BR2 uranium in Dounreay justified 10 years ago the qualification and use of this material. After some preliminary test irradiations, various batches of fuel elements were fabricated by the UKAEA-Dounreay and successfully irradiated. Due to their lower 235 U content (0.050 g 235 U/cm 2 ), these elements were always irradiated together with standard 90...93% HEU fuel elements. A mixed-core strategy was developed at this occasion for an optimal utilization, and was reported during the 4th RRFM conference (March 19-21, 2000, Colmar, France). The availability of a new batch of fresh 73% HEU material was the occasion, a few years ago, to initiate the development, fabrication and qualification of a new high density fuel element. An order was placed with CERCA to assess the optimal fabrication methods and tooling required to meet as far as possible the existing BR2 standard specifications and 235 U content (0.060 g 235 U/cm 2 ). This development phase has been already reported during the 7th RRFM conference (March 9-12, 2003, Aix-en-Provence, France). Afterwards, six lead test fuel elements were ordered for qualification by irradiation. The neutronic properties of the fuel elements were adjusted and optimized. After a short summary of the main results of the development program, this paper describes the nuclear characteristics of the high density fuel elements and comments on the nuclear follow-up of the lead test fuel elements during their irradiation for five cycles in the BR2 reactor and the return of experience for CERCA. (author)

  1. Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection.

    Directory of Open Access Journals (Sweden)

    Marie Samanovic

    2009-01-01

    Full Text Available Innate immunity is the first line of defense against invading microorganisms. Trypanosome Lytic Factor (TLF is a minor sub-fraction of human high-density lipoprotein that provides innate immunity by completely protecting humans from infection by most species of African trypanosomes, which belong to the Kinetoplastida order. Herein, we demonstrate the broader protective effects of human TLF, which inhibits intracellular infection by Leishmania, a kinetoplastid that replicates in phagolysosomes of macrophages. We show that TLF accumulates within the parasitophorous vacuole of macrophages in vitro and reduces the number of Leishmania metacyclic promastigotes, but not amastigotes. We do not detect any activation of the macrophages by TLF in the presence or absence of Leishmania, and therefore propose that TLF directly damages the parasite in the acidic parasitophorous vacuole. To investigate the physiological relevance of this observation, we have reconstituted lytic activity in vivo by generating mice that express the two main protein components of TLFs: human apolipoprotein L-I and haptoglobin-related protein. Both proteins are expressed in mice at levels equivalent to those found in humans and circulate within high-density lipoproteins. We find that TLF mice can ameliorate an infection with Leishmania by significantly reducing the pathogen burden. In contrast, TLF mice were not protected against infection by the kinetoplastid Trypanosoma cruzi, which infects many cell types and transiently passes through a phagolysosome. We conclude that TLF not only determines species specificity for African trypanosomes, but can also ameliorate an infection with Leishmania, while having no effect on T. cruzi. We propose that TLFs are a component of the innate immune system that can limit infections by their ability to selectively damage pathogens in phagolysosomes within the reticuloendothelial system.

  2. Energy transfer networks: Quasicontinuum photoluminescence linked to high densities of defects

    Science.gov (United States)

    Laurence, Ted A.; Ly, Sonny; Bude, Jeff D.; Baxamusa, Salmaan H.; Lepró, Xavier; Ehrmann, Paul

    2017-11-01

    In a series of studies related to laser-induced damage of optical materials and deposition of plastics, we discovered a broadly emitting photoluminescence with fast lifetimes that we termed quasicontinuum photoluminescence (QC-PL). Here, we suggest that a high density of optically active defects leads to QC-PL, where interactions between defects affect the temporal and spectral characteristics of both excitation and emission. We develop a model that predicts the temporal characteristics of QC-PL, based on energy transfer interactions between high densities of defects. Our model does not explain all spectral broadening and redshifts found in QC-PL, since we do not model spectral changes in defects due to proximity to other defects. However, we do provide an example of a well-defined system that exhibits the QC-PL characteristics of a distribution in shortened lifetimes and broadened, redshifted energy levels: an organic chromophore (fluorescein) that has been dried rapidly on a fused silica surface. Recently, we showed that regions of fused silica exposed to up to 1 billion high-fluence laser shots at 351 rm nm at subdamage fluences exhibit significant transmission losses at the surface. Here, we find that these laser-exposed regions also exhibit QC-PL. Increases in the density of induced defects on these laser-exposed surfaces, as measured by the local transmission loss, lead to decreases in the observed lifetime and redshifts in the spectrum of the QC-PL, consistent with our explanation for QC-PL. We have found QC-PL in an increasing variety of situations and materials, and we believe it is a phenomenon commonly found on surfaces and nanostructured materials.

  3. The Experimental Demonstration of the Optimized Electrical Probe Memory for Ultra-High Density Recording.

    Science.gov (United States)

    Wang, Lei; Gong, Sidi; Yang, Cihui; Wen, Jing

    2017-01-01

    A theoretical model has been previously proposed to optimize the structure of the electrical probe memory system, whereby the optimal thickness and resistivity of DLC capping layer and TiN under layer are predicted to be 2 nm, 0.01 Ωm, and 40 nm, 2×10-7 Ωm,respectively However, there is no experimental evidence to show that such a media stack can be fabricated in reality by the time of writing and few patents regarding this intriguing topic have been reviewed and cited. In order to realize this optimized design experimentally, the thickness dependent resistivity for both DLC and TiN film are assessed, from which it is not possible to obtain a media stack with exactly the same properties as the optimized design. Therefore, the previously proposed architecture is re-optimized using the measured properties values, and the capability of using the modified memory architecture to provide ultra-high density, high data rate, and low energy consumption is demonstrated. The results show that it is difficult to experimentally attain an electrical probe memory with exactly the same properties values as the optimized counterpart. An optimized electrical probe memory structure that includes a DLC capping layer and TiN under layer was previously proposed according to a parametric approach, while the practicality of realizing such a media stack experimentally has not bee investigated. In order to assess its practical feasibility, we first measured the electrical resistivities of DLC and TiN films for different thicknesses. In this case, for the purpose of optimizing the memory system with appropriate, but more physically realistic properties values, we re-designed the architecture using the measured properties, and the modified system is able to provide ultra-high density, large data rate, and low energy consumption. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  4. Unsupervised neural spike sorting for high-density microelectrode arrays with convolutive independent component analysis.

    Science.gov (United States)

    Leibig, Christian; Wachtler, Thomas; Zeck, Günther

    2016-09-15

    Unsupervised identification of action potentials in multi-channel extracellular recordings, in particular from high-density microelectrode arrays with thousands of sensors, is an unresolved problem. While independent component analysis (ICA) achieves rapid unsupervised sorting, it ignores the convolutive structure of extracellular data, thus limiting the unmixing to a subset of neurons. Here we present a spike sorting algorithm based on convolutive ICA (cICA) to retrieve a larger number of accurately sorted neurons than with instantaneous ICA while accounting for signal overlaps. Spike sorting was applied to datasets with varying signal-to-noise ratios (SNR: 3-12) and 27% spike overlaps, sampled at either 11.5 or 23kHz on 4365 electrodes. We demonstrate how the instantaneity assumption in ICA-based algorithms has to be relaxed in order to improve the spike sorting performance for high-density microelectrode array recordings. Reformulating the convolutive mixture as an instantaneous mixture by modeling several delayed samples jointly is necessary to increase signal-to-noise ratio. Our results emphasize that different cICA algorithms are not equivalent. Spike sorting performance was assessed with ground-truth data generated from experimentally derived templates. The presented spike sorter was able to extract ≈90% of the true spike trains with an error rate below 2%. It was superior to two alternative (c)ICA methods (≈80% accurately sorted neurons) and comparable to a supervised sorting. Our new algorithm represents a fast solution to overcome the current bottleneck in spike sorting of large datasets generated by simultaneous recording with thousands of electrodes. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

    Directory of Open Access Journals (Sweden)

    Mehdi Shakibaei

    Full Text Available OBJECTIVE: Treatment of colorectal cancer (CRC remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC are capable of surviving conventional chemotherapies that permits regeneration of original tumors. Therefore, we investigated the effectiveness of 5-FU and plant polyphenol (curcumin in context of DNA mismatch repair (MMR status and CSC activity in 3D cultures of CRC cells. METHODS: High density 3D cultures of CRC cell lines HCT116, HCT116+ch3 (complemented with chromosome 3 and their corresponding isogenic 5-FU-chemo-resistant derivative clones (HCT116R, HCT116+ch3R were treated with 5-FU either without or with curcumin in time- and dose-dependent assays. RESULTS: Pre-treatment with curcumin significantly enhanced the effect of 5-FU on HCT116R and HCR116+ch3R cells, in contrast to 5-FU alone as evidenced by increased disintegration of colonospheres, enhanced apoptosis and by inhibiting their growth. Curcumin and/or 5-FU strongly affected MMR-deficient CRC cells in high density cultures, however MMR-proficient CRC cells were more sensitive. These effects of curcumin in enhancing chemosensitivity to 5-FU were further supported by its ability to effectively suppress CSC pools as evidenced by decreased number of CSC marker positive cells, highlighting the suitability of this 3D culture model for evaluating CSC marker expression in a close to vivo setting. CONCLUSION: Our results illustrate novel and previously unrecognized effects of curcumin in enhancing chemosensitization to 5-FU-based chemotherapy on DNA MMR-deficient and their chemo-resistant counterparts by targeting the CSC sub-population. (246 words in abstract.

  6. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

    Science.gov (United States)

    Shakibaei, Mehdi; Buhrmann, Constanze; Kraehe, Patricia; Shayan, Parviz; Lueders, Cora; Goel, Ajay

    2014-01-01

    Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC) are capable of surviving conventional chemotherapies that permits regeneration of original tumors. Therefore, we investigated the effectiveness of 5-FU and plant polyphenol (curcumin) in context of DNA mismatch repair (MMR) status and CSC activity in 3D cultures of CRC cells. High density 3D cultures of CRC cell lines HCT116, HCT116+ch3 (complemented with chromosome 3) and their corresponding isogenic 5-FU-chemo-resistant derivative clones (HCT116R, HCT116+ch3R) were treated with 5-FU either without or with curcumin in time- and dose-dependent assays. Pre-treatment with curcumin significantly enhanced the effect of 5-FU on HCT116R and HCR116+ch3R cells, in contrast to 5-FU alone as evidenced by increased disintegration of colonospheres, enhanced apoptosis and by inhibiting their growth. Curcumin and/or 5-FU strongly affected MMR-deficient CRC cells in high density cultures, however MMR-proficient CRC cells were more sensitive. These effects of curcumin in enhancing chemosensitivity to 5-FU were further supported by its ability to effectively suppress CSC pools as evidenced by decreased number of CSC marker positive cells, highlighting the suitability of this 3D culture model for evaluating CSC marker expression in a close to vivo setting. Our results illustrate novel and previously unrecognized effects of curcumin in enhancing chemosensitization to 5-FU-based chemotherapy on DNA MMR-deficient and their chemo-resistant counterparts by targeting the CSC sub-population. (246 words in abstract).

  7. Simulating the Evolving Behavior of Secondary Slow Slip Fronts

    Science.gov (United States)

    Peng, Y.; Rubin, A. M.

    2017-12-01

    High-resolution tremor catalogs of slow slip events reveal secondary slow slip fronts behind the main front that repetitively occupy the same source area during a single episode. These repetitive fronts are most often observed in regions with high tremor density. Their recurrence intervals gradually increase from being too short to be tidally modulated (tens of minutes) to being close to tidal periods (about 12 or 24 hours). This could be explained by a decreasing loading rate from creep in the surrounding regions (with few or no observable tremor events) as the main front passes by. As the recurrence intervals of the fronts increase, eventually they lock in on the tidal periods. We attempt to simulate this numerically using a rate-and-state friction law that transitions from velocity-weakening at low slip speeds to velocity strengthening at high slip speeds. Many small circular patches with a cutoff velocity an order of magnitude higher than that of the background are randomly placed on the fault, in order to simulate the average properties of the high-density tremor zone. Preliminary results show that given reasonable parameters, this model produces similar propagation speeds of the forward-migrating main front inside and outside the high-density tremor zone, consistent with observations. We will explore the behavior of the secondary fronts that arise in this model, in relation to the local density of the small tremor-analog patches, the overall geometry of the tremor zone and the tides.

  8. Genetically elevated apolipoprotein A-I, high-density lipoprotein cholesterol levels, and risk of ischemic heart disease

    DEFF Research Database (Denmark)

    Lundegaard, Christiane; Tybjærg-Hansen, Anne; Grande, Peer

    2010-01-01

    Epidemiologically, levels of high-density lipoprotein (HDL) cholesterol and its major protein constituent, apolipoprotein A-I (apoA-I), are inversely related to risk of ischemic heart disease (IHD).......Epidemiologically, levels of high-density lipoprotein (HDL) cholesterol and its major protein constituent, apolipoprotein A-I (apoA-I), are inversely related to risk of ischemic heart disease (IHD)....

  9. PRIVACY AS A CULTURAL VALUE WITHIN TRADITIONAL IRANIAN HOUSING: Lessons for Modern Iranian High Density Vertical Development Housing

    OpenAIRE

    Siyamak Nayyeri Fallah; Akram Khalili; Mohamad Tajuddin Mohamad Rasdi

    2015-01-01

    The role of value of privacy in shaping Iranian culture is vital. In contrary to modern middle-class Iranian high density vertical development housing, this cultural principle plays a great role in shaping spatial organization of Iranian traditional housing. The aim of this study is to establish a framework to improve spatial organization of modern Iranian high density vertical development (HDVD) housing through lessons learnt from traditional Iranian housing. In this regard, to reach the aim...

  10. Surface nanostructuring of LiNbO3 by high-density electronic excitations

    International Nuclear Information System (INIS)

    El-Said, A.S.; Wilhelm, R.A.; Facsko, S.; Trautmann, C.

    2013-01-01

    Lithium niobate (LiNbO 3 ) single crystals were irradiated with high energy gold ions (0.5–2.2 GeV) at the UNILAC (GSI) and with 150-keV highly charged xenon ions from an EBIT (Electron Beam Ion Trap, HZDR). The surfaces of the irradiated crystals were analyzed by scanning force microscopy showing very similar topographic changes. Swift heavy ions and slow highly charged ions produce hillock-like nanostructures on the surface. In both cases, the energy deposition of the ions is characterized by dense localized electronic excitations and efficient transfer to the lattice. Furthermore, the irradiation results in a shift in the band gap energy as evidenced by UV–Vis absorption spectroscopy. Specific modifications (e.g. hillock size, energy loss threshold) induced by slow highly charged ions are discussed in comparison with effects due to the electronic energy loss by swift heavy ions

  11. Surface nanostructuring of LiNbO{sub 3} by high-density electronic excitations

    Energy Technology Data Exchange (ETDEWEB)

    El-Said, A.S., E-mail: elsaid@kfupm.edu.sa [Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden (Germany); Physics Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Nuclear and Radiation Physics Lab, Physics Department, Faculty of Science, Mansoura University, 35516 Mansoura (Egypt); Wilhelm, R.A. [Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden (Germany); Technische Universität Dresden, 01062 Dresden (Germany); Facsko, S. [Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden (Germany); Trautmann, C. [GSI Helmholtz Centre for Heavy Ion Research, 64291 Darmstadt (Germany); Technische Universität Darmstadt, 64289 Darmstadt (Germany)

    2013-11-15

    Lithium niobate (LiNbO{sub 3}) single crystals were irradiated with high energy gold ions (0.5–2.2 GeV) at the UNILAC (GSI) and with 150-keV highly charged xenon ions from an EBIT (Electron Beam Ion Trap, HZDR). The surfaces of the irradiated crystals were analyzed by scanning force microscopy showing very similar topographic changes. Swift heavy ions and slow highly charged ions produce hillock-like nanostructures on the surface. In both cases, the energy deposition of the ions is characterized by dense localized electronic excitations and efficient transfer to the lattice. Furthermore, the irradiation results in a shift in the band gap energy as evidenced by UV–Vis absorption spectroscopy. Specific modifications (e.g. hillock size, energy loss threshold) induced by slow highly charged ions are discussed in comparison with effects due to the electronic energy loss by swift heavy ions.

  12. Coaxial slow source

    International Nuclear Information System (INIS)

    Brooks, R.D.; Jarboe, T.R.

    1990-01-01

    Field reversed configurations (FRCs) are a class of compact toroid with not toroidal field. The field reversed theta pinch technique has been successfully used for formation of FRCs since their inception in 1958. In this method an initial bias field is produced. After ionization of the fill gas, the current in the coil is rapidly reversed producing the radial implosion of a current sheath. At the ends of the coil the reversed field lines rapidly tear and reconnect with the bias field lines until no more bias flux remains. At this point, vacuum reversed field accumulates around the configuration which contracts axially until an equilibrium is reached. When extrapolating the use of such a technique to reactor size plasmas two main shortcomings are found. First, the initial bias field, and hence flux in a given device, which can be reconnected to form the configuration is limited from above by destructive axial dynamics. Second, the voltages required to produce rapid current reversal in the coil are very large. Clearly, a low voltage formation technique without limitations on flux addition is desirable. The Coaxial Slow Source (CSS) device was designed to meet this need. It has two coaxial theta pinch coils. Coaxial coil geometry allows for the addition of as much magnetic flux to the annular plasma between them as can be generated inside the inner coil. Furthermore the device can be operated at charging voltages less than 10 kV and on resistive diffusion, rather than implosive time scales. The inner coil is a novel, concentric, helical design so as to allow it to be cantilevered on one end to permit translation of the plasma. Following translation off the inner coil the Annular Field Reversed Configuration would be re-formed as a true FRC. In this paper we investigate the formation process in the new parallel configuration., CSSP, in which the inner and outer coils are connected in parallel to the main capacitor bank

  13. Fiber optic chemical sensors: The evolution of high- density fiber-optic DNA microarrays

    Science.gov (United States)

    Ferguson, Jane A.

    2001-06-01

    Sensors were developed for multianalyte monitoring, fermentation monitoring, lactate analysis, remote oxygen detection for use in bioremediation monitoring and in a fuel spill clean-up project, heavy metal analysis, and high density DNA microarrays. The major focus of this thesis involved creating and improving high-density DNA gene arrays. Fiber optic sensors are created using fluorescent indicators, polymeric supports, and optical fiber substrates. The fluorescent indicator is entrapped in a polymer layer and attached to the tip of the optical fiber. The tip of the fiber bearing the sensing layer (the distal end) is placed in the sample of interest while the other end of the fiber (the proximal end) is connected to an analysis system. Any length of fiber can be used without compromising the integrity or sensitivity of the system. A fiber optic oxygen sensor was designed incorporating an oxygen sensitive fluorescent dye and a gas permeable polymer attached to an optical fiber. The construction simplicity and ruggedness of the sensor enabled its deployment for in situ chemical oxidation and bioremediation studies. Optical fibers were also used as the substrate to detect biomolecules in solution. To monitor bioprocesses, the production of the analyte of interest must be coupled with a species that is optically measurable. For example, oxygen is consumed in many metabolic functions. The fiber optic oxygen sensor is equipped with an additional sensing layer. Upon contact with a specific biochemical in the sample, a reaction occurs in the additional sensing layer that either consumes or produces oxygen. This dual layer system was used to monitor the presence of lactate, an important metabolite for clinical and bioprocess analysis. In many biological and environmental systems, the generation of one species occurs coincidentally with the generation or consumption of another species. A multianalyte sensor was prepared that can monitor the simultaneous activity of pH, CO2

  14. A high-density genetic map of Arachis duranensis, a diploid ancestor of cultivated peanut

    Directory of Open Access Journals (Sweden)

    Nagy Ervin D

    2012-09-01

    Full Text Available Abstract Background Cultivated peanut (Arachis hypogaea is an allotetraploid species whose ancestral genomes are most likely derived from the A-genome species, A. duranensis, and the B-genome species, A. ipaensis. The very recent (several millennia evolutionary origin of A. hypogaea has imposed a bottleneck for allelic and phenotypic diversity within the cultigen. However, wild diploid relatives are a rich source of alleles that could be used for crop improvement and their simpler genomes can be more easily analyzed while providing insight into the structure of the allotetraploid peanut genome. The objective of this research was to establish a high-density genetic map of the diploid species A. duranensis based on de novo generated EST databases. Arachis duranensis was chosen for mapping because it is the A-genome progenitor of cultivated peanut and also in order to circumvent the confounding effects of gene duplication associated with allopolyploidy in A. hypogaea. Results More than one million expressed sequence tag (EST sequences generated from normalized cDNA libraries of A. duranensis were assembled into 81,116 unique transcripts. Mining this dataset, 1236 EST-SNP markers were developed between two A. duranensis accessions, PI 475887 and Grif 15036. An additional 300 SNP markers also were developed from genomic sequences representing conserved legume orthologs. Of the 1536 SNP markers, 1054 were placed on a genetic map. In addition, 598 EST-SSR markers identified in A. hypogaea assemblies were included in the map along with 37 disease resistance gene candidate (RGC and 35 other previously published markers. In total, 1724 markers spanning 1081.3 cM over 10 linkage groups were mapped. Gene sequences that provided mapped markers were annotated using similarity searches in three different databases, and gene ontology descriptions were determined using the Medicago Gene Atlas and TAIR databases. Synteny analysis between A. duranensis, Medicago

  15. Exploring properties of high-density matter through remnants of neutron-star mergers

    Energy Technology Data Exchange (ETDEWEB)

    Bauswein, Andreas [Aristotle University of Thessaloniki, Department of Physics, Thessaloniki (Greece); Heidelberger Institut fuer Theoretische Studien, Heidelberg (Germany); Stergioulas, Nikolaos [Aristotle University of Thessaloniki, Department of Physics, Thessaloniki (Greece); Janka, Hans-Thomas [Max-Planck-Institut fuer Astrophysik, Garching (Germany)

    2016-03-15

    Remnants of neutron-star mergers are essentially massive, hot, differentially rotating neutron stars, which are initially strongly oscillating. As such they represent a unique probe for high-density matter because the oscillations are detectable via gravitational-wave measurements and are strongly dependent on the equation of state. The impact of the equation of state for instance is apparent in the frequency of the dominant oscillation mode of the remnant. For a fixed total binary mass a tight relation between the dominant postmerger oscillation frequency and the radii of nonrotating neutron stars exists. Inferring observationally the dominant postmerger frequency thus determines neutron star radii with high accuracy of the order of a few hundred meters. By considering symmetric and asymmetric binaries of the same chirp mass, we show that the knowledge of the binary mass ratio is not critical for this kind of radius measurements. We perform simulations which show that initial intrinsic neutron star rotation is unlikely to affect this method of constraining the high-density equation of state. We also summarize different possibilities about how the postmerger gravitational-wave emission can be employed to deduce the maximum mass of nonrotating neutron stars. We clarify the nature of the three most prominent features of the postmerger gravitational-wave spectrum and argue that the merger remnant can be considered to be a single, isolated, self-gravitating object that can be described by concepts of asteroseismology. We sketch how the consideration of the strength of secondary gravitational-wave peaks leads to a classification scheme of the gravitational-wave emission and postmerger dynamics. The understanding of the different mechanisms shaping the gravitational-wave signal yields a physically motivated analytic model of the gravitational-wave emission, which may form the basis for template-based gravitational-wave data analysis. We explore the observational

  16. CGHScan: finding variable regions using high-density microarray comparative genomic hybridization data

    Directory of Open Access Journals (Sweden)

    Rajashekara Gireesh

    2006-04-01

    Full Text Available Abstract Background Comparative genomic hybridization can rapidly identify chromosomal regions that vary between organisms and tissues. This technique has been applied to detecting differences between normal and cancerous tissues in eukaryotes as well as genomic variability in microbial strains and species. The density of oligonucleotide probes available on current microarray platforms is particularly well-suited for comparisons of organisms with smaller genomes like bacteria and yeast where an entire genome can be assayed on a single microarray with high resolution. Available methods for analyzing these experiments typically confine analyses to data from pre-defined annotated genome features, such as entire genes. Many of these methods are ill suited for datasets with the number of measurements typical of high-density microarrays. Results We present an algorithm for analyzing microarray hybridization data to aid identification of regions that vary between an unsequenced genome and a sequenced reference genome. The program, CGHScan, uses an iterative random walk approach integrating multi-layered significance testing to detect these regions from comparative genomic hybridization data. The algorithm tolerates a high level of noise in measurements of individual probe intensities and is relatively insensitive to the choice of method for normalizing probe intensity values and identifying probes that differ between samples. When applied to comparative genomic hybridization data from a published experiment, CGHScan identified eight of nine known deletions in a Brucella ovis strain as compared to Brucella melitensis. The same result was obtained using two different normalization methods and two different scores to classify data for individual probes as representing conserved or variable genomic regions. The undetected region is a small (58 base pair deletion that is below the resolution of CGHScan given the array design employed in the study

  17. Biomimetic porous high-density polyethylene/polyethylene- grafted-maleic anhydride scaffold with improved in vitro cytocompatibility.

    Science.gov (United States)

    Sharma, Swati; Bhaskar, Nitu; Bose, Surjasarathi; Basu, Bikaramjit

    2018-05-01

    A major challenge for tissue engineering is to design and to develop a porous biocompatible scaffold, which can mimic the properties of natural tissue. As a first step towards this endeavour, we here demonstrate a distinct methodology in biomimetically synthesized porous high-density polyethylene scaffolds. Co-extrusion approach was adopted, whereby high-density polyethylene was melt mixed with polyethylene oxide to form an immiscible binary blend. Selective dissolution of polyethylene oxide from the biphasic system revealed droplet-matrix-type morphology. An attempt to stabilize such morphology against thermal and shear effects was made by the addition of polyethylene- grafted-maleic anhydride as a compatibilizer. A maximum ultimate tensile strength of 7 MPa and elastic modulus of 370 MPa were displayed by the high-density polyethylene/polyethylene oxide binary blend with 5% maleated polyethylene during uniaxial tensile loading. The cell culture experiments with murine myoblast C2C12 cell line indicated that compared to neat high-density polyethylene and high-density polyethylene/polyethylene oxide, the high-density polyethylene/polyethylene oxide with 5% polyethylene- grafted-maleic anhydride scaffold significantly increased muscle cell attachment and proliferation with distinct elongated threadlike appearance and highly stained nuclei, in vitro. This has been partly attributed to the change in surface wettability property with a reduced contact angle (∼72°) for 5% PE- g-MA blends. These findings suggest that the high-density polyethylene/polyethylene oxide with 5% polyethylene- grafted-maleic anhydride can be treated as a cell growth substrate in bioengineering applications.

  18. A high-density EEG investigation into steady state binaural beat stimulation.

    Directory of Open Access Journals (Sweden)

    Peter Goodin

    Full Text Available Binaural beats are an auditory phenomenon that has been suggested to alter physiological and cognitive processes including vigilance and brainwave entrainment. Some personality traits measured by the NEO Five Factor Model have been found to alter entrainment using pulsing light stimuli, but as yet no studies have examined if this occurs using steady state presentation of binaural beats for a relatively short presentation of two minutes. This study aimed to examine if binaural beat stimulation altered vigilance or cortical frequencies and if personality traits were involved. Thirty-one participants were played binaural beat stimuli designed to elicit a response at either the Theta (7 Hz or Beta (16 Hz frequency bands while undertaking a zero-back vigilance task. EEG was recorded from a high-density electrode cap. No significant differences were found in vigilance or cortical frequency power during binaural beat stimulation compared to a white noise control period. Furthermore, no significant relationships were detected between the above and the Big Five personality traits. This suggests a short presentation of steady state binaural beats are not sufficient to alter vigilance or entrain cortical frequencies at the two bands examined and that certain personality traits were not more susceptible than others.

  19. SNP discovery and development of a high-density genotyping array for sunflower.

    Directory of Open Access Journals (Sweden)

    Eleni Bachlava

    Full Text Available Recent advances in next-generation DNA sequencing technologies have made possible the development of high-throughput SNP genotyping platforms that allow for the simultaneous interrogation of thousands of single-nucleotide polymorphisms (SNPs. Such resources have the potential to facilitate the rapid development of high-density genetic maps, and to enable genome-wide association studies as well as molecular breeding approaches in a variety of taxa. Herein, we describe the development of a SNP genotyping resource for use in sunflower (Helianthus annuus L.. This work involved the development of a reference transcriptome assembly for sunflower, the discovery of thousands of high quality SNPs based on the generation and analysis of ca. 6 Gb of transcriptome re-sequencing data derived from multiple genotypes, the selection of 10,640 SNPs for inclusion in the genotyping array, and the use of the resulting array to screen a diverse panel of sunflower accessions as well as related wild species. The results of this work revealed a high frequency of polymorphic SNPs and relatively high level of cross-species transferability. Indeed, greater than 95% of successful SNP assays revealed polymorphism, and more than 90% of these assays could be successfully transferred to related wild species. Analysis of the polymorphism data revealed patterns of genetic differentiation that were largely congruent with the evolutionary history of sunflower, though the large number of markers allowed for finer resolution than has previously been possible.

  20. Transport analysis of high radiation and high density plasmas in the ASDEX Upgrade tokamak

    Directory of Open Access Journals (Sweden)

    Casali L.

    2014-01-01

    Full Text Available Future fusion reactors, foreseen in the “European road map” such as DEMO, will operate under more demanding conditions compared to present devices. They will require high divertor and core radiation by impurity seeding to reduce heat loads on divertor target plates. In addition, DEMO will have to work at high core densities to reach adequate fusion performance. The performance of fusion reactors depends on three essential parameters: temperature, density and energy confinement time. The latter characterizes the loss rate due to both radiation and transport processes. The DEMO foreseen scenarios described above were not investigated so far, but are now addressed at the ASDEX Upgrade tokamak. In this work we present the transport analysis of such scenarios. Plasma with high radiation by impurity seeding: transport analysis taking into account the radiation distribution shows no change in transport during impurity seeding. The observed confinement improvement is an effect of higher pedestal temperatures which extend to the core via stiffness. A non coronal radiation model was developed and compared to the bolometric measurements in order to provide a reliable radiation profile for transport calculations. High density plasmas with pellets: the analysis of kinetic profiles reveals a transient phase at the start of the pellet fuelling due to a slower density build up compared to the temperature decrease. The low particle diffusion can explain the confinement behaviour.

  1. Probing the nuclear symmetry energy at high densities with nuclear reactions

    Science.gov (United States)

    Leifels, Y.

    2017-11-01

    The nuclear equation of state is a topic of highest current interest in nuclear structure and reactions as well as in astrophysics. The symmetry energy is the part of the equation of state which is connected to the asymmetry in the neutron/proton content. During recent years a multitude of experimental and theoretical efforts on different fields have been undertaken to constraint its density dependence at low densities but also above saturation density (ρ_0=0.16 fm ^{-3} . Conventionally the symmetry energy is described by its magnitude S_v and the slope parameter L , both at saturation density. Values of L = 44 -66MeV and S_v=31 -33MeV have been deduced in recent compilations of nuclear structure, heavy-ion reaction and astrophysics data. Apart from astrophysical data on mass and radii of neutron stars, heavy-ion reactions at incident energies of several 100MeV are the only means do access the high density behaviour of the symmetry energy. In particular, meson production and collective flows upto about 1 AGeV are predicted to be sensitive to the slope of the symmetry energy as a function of density. From the measurement of elliptic flow of neutrons with respect to charged particles at GSI, a more stringent constraint for the slope of the symmetry energy at supra-saturation densities has been deduced. Future options to reach even higher densities will be discussed.

  2. High-density lipoproteins: a novel therapeutic target for cardiovascular disease

    Directory of Open Access Journals (Sweden)

    TS Mohamed Saleem

    2011-01-01

    Full Text Available TS Mohamed Saleem1, PV Sandhya Rani1, K Gauthaman21Department of Pharmacology, Annamacharya College of Pharmacy, New Boyanapalli, Andhrapradesh, India; 2Department of Drug Technology, Faculty of Medical Technology, Derna, LibyaAbstract: Cardiovascular disease has a high rate of mortality in both Western and developing countries. Atherosclerosis and generation of reactive oxygen species through oxidative stress is the major risk factor for cardiovascular disease. Atherothrombosis with low levels of high-density lipoprotein (HDL and high levels of low-density lipoprotein is a major risk factor for atherosclerosis-induced cardiovascular disease. Lipid-lowering drugs like statins, niacin, fibrates, and some newer agents, ie, the apolipoprotein A-I mimetics and the cholesteryl ester transfer protein inhibitors, not only increase HDL levels but are also effective in reducing key atherogenic lipid components, including triglyceride-rich lipoproteins. The aim of this review is to discuss the accumulating evidence suggesting that HDL possesses a diverse range of biological actions, and that increasing HDL levels by drug treatment may be beneficial in the prevention of cardiovascular disease.Keywords: cardiovascular disease, lipoproteins, statins, apolipoprotein, atherosclerosis

  3. High-density lipoproteincholesterol, reverse cholesterol transport, and cardiovascular risk: a tale of genetics?

    Directory of Open Access Journals (Sweden)

    Giovanni Cimmino

    2013-10-01

    Full Text Available Cholesterol deposition plays a central role in atherogenesis. The accumulation of lipid material is the result of an imbalance between the influx and efflux of cholesterol within the arterial wall. High levels of plasma low-density lipoprotein-cholesterol are considered the major mechanism responsible for the influx and accumulation of cholesterol in the arterial wall, while high-density lipoprotein (HDL- cholesterol seems responsible for its efflux. The mechanism by which cholesterol is removed from extra-hepatic organs and delivered to the liver for its catabolism and excretion is called reverse cholesterol transport (RCT. Epidemiological evidence has associated high levels of HDL-cholesterol/ApoA-I with protection against atherosclerotic disease, but the ultimate mechanism(s responsible for the beneficial effect is not well established. HDLs are synthesized by the liver and small intestine and released to the circulation as a lipid-poor HDL (nascent HDL, mostly formed by ApoA-I and phospholipids. Through their metabolic maturation, HDLs interact with the ABCA1 receptor in the macrophage surface increasing their lipid content by taking phospholipids and cholesterol from macrophages becoming mature HDL. The cholesterol of the HDLs is transported to the liver, via the scavenger receptor class B, type I, for further metabolization and excretion to the intestines in the form of bile acids and cholesterol, completing the process of RCT. It is clear that an inherited mutation or acquired abnormality in any of the key players in RCT mat affect the atherosclerotic process.

  4. Execution of a protocol for the supplier selection of a high density polyolefin

    International Nuclear Information System (INIS)

    Flores Pina, Lizette

    2013-01-01

    A new supplier of high-density polyolefin is selected for a medical industry, as a contingency plan in case the current provider presents problems of raw material supply. The Purchasing Department has coordinated the selection of the new resin supplier, providing high quality standards, deadlines and convenient price. The new resin obtained from the new provider was subjected to the protocol. The necessary tests were established for the comparison between the two resins (resin current and new resin). The tests were executed in a laboratory supported by the company in the United States. The tests most significant have corresponded to infrared Fourier transform tests, differential scanning calorimetry, melt flow rate and thermo gravimetry. Tests have defined the main characteristics of both resins with positive results and complying with the specifications set by the protocol. The two resins were established as such to be used in the production process of the product. Comparison phase of results are completely proceeding to execute the validation of the resin to run a test then preset design [es

  5. Methods for Estimating Environmental Effects and Constraints on NexGen: High Density Case Study

    Science.gov (United States)

    Augustine, S.; Ermatinger, C.; Graham, M.; Thompson, T.

    2010-01-01

    This document provides a summary of the current methods developed by Metron Aviation for the estimate of environmental effects and constraints on the Next Generation Air Transportation System (NextGen). This body of work incorporates many of the key elements necessary to achieve such an estimate. Each section contains the background and motivation for the technical elements of the work, a description of the methods used, and possible next steps. The current methods described in this document were selected in an attempt to provide a good balance between accuracy and fairly rapid turn around times to best advance Joint Planning and Development Office (JPDO) System Modeling and Analysis Division (SMAD) objectives while also supporting the needs of the JPDO Environmental Working Group (EWG). In particular this document describes methods applied to support the High Density (HD) Case Study performed during the spring of 2008. A reference day (in 2006) is modeled to describe current system capabilities while the future demand is applied to multiple alternatives to analyze system performance. The major variables in the alternatives are operational/procedural capabilities for airport, terminal, and en route airspace along with projected improvements to airframe, engine and navigational equipment.

  6. Turbulence at the transition to the high density H-mode in Wendelstein 7-AS plasmas

    Science.gov (United States)

    Basse, N. P.; Zoletnik, S.; Bäumel, S.; Endler, M.; Hirsch, M.; McCormick, K.; Werner, A.; W7-AS Team

    2003-01-01

    Recently a new improved confinement regime was found in the Wendelstein 7-AS (W7-AS) stellarator (Renner H. et al 1989 Plasma Phys. Control. Fusion 31 1579). The discovery of this high density high confinement mode (HDH-mode) was facilitated by the installation of divertor modules. In this paper, measurements of short wavelength density fluctuations in the HDH-mode using collective scattering of infrared light are presented. These measurements will be contrasted to fluctuations during normal confinement operation (NC-mode). The autopower spectra of the measurements show a consistent increase of the fluctuation level associated with the transition from NC- to HDH-mode. Correlation calculations on a 20 μs timescale between magnetic and density fluctuations lead to the result that the fluctuations are correlated in NC-but not in HDH-mode. Finally, a comparative analysis between the enhanced Dα H-mode (EDA H-mode) found in the Alcator C-Mod tokamak and the HDH-mode in W7-AS is carried out.

  7. Wax co-cracking synergism of high density polyethylene to alternative fuels

    Directory of Open Access Journals (Sweden)

    Magdy Motawie

    2015-09-01

    Full Text Available Attempts have been made to understand the thermal degradation of high density polyethylene (HDPE and their combined co-cracking using different ratios of HDPE and petroleum wax under nitrogen atmosphere. We have conducted the experiments using HDPE as the raw material and petroleum wax as co-feed by at 400 and 450 °C reaction temperatures. The product distribution was noted along with reaction time of 0.5–3 h for the degradation. Thermal gravimetric analysis (TGA technique was used to measure the weight change of the feedstock as a function of temperature and time. Differential scanning calorimetry (DSC was used to determine the degradation temperature. Products were characterized using gas chromatography (GC and infrared spectroscopy (FTIR, some other standard physical methods were used to determine the main properties of the liquid products. Results show that the mixed plastic-wax samples could be converted into gases, gasoline, and middle distillate depending upon the composition of feed polymer/wax ratio. It was found that the products mostly consisted of paraffin and olefin compounds, with carbon numbers of C1–C4, C5–C9 and C10–C19 in the case of gases, gasoline and middle distillate respectively.

  8. Pattern recognition with adaptive-thresholds for sleep spindle in high density EEG signals.

    Science.gov (United States)

    Gemignani, Jessica; Agrimi, Jacopo; Cheli, Enrico; Gemignani, Angelo; Laurino, Marco; Allegrini, Paolo; Landi, Alberto; Menicucci, Danilo

    2015-01-01

    Medicine and Surgery, University of Pisa, via Savi 10, 56126, Pisa, Italy Sleep spindles are electroencephalographic oscillations peculiar of non-REM sleep, related to neuronal mechanisms underlying sleep restoration and learning consolidation. Based on their very singular morphology, sleep spindles can be visually recognized and detected, even though this approach can lead to significant mis-detections. For this reason, many efforts have been put in developing a reliable algorithm for spindle automatic detection, and a number of methods, based on different techniques, have been tested via visual validation. This work aims at improving current pattern recognition procedures for sleep spindles detection by taking into account their physiological sources of variability. We provide a method as a synthesis of the current state of art that, improving dynamic threshold adaptation, is able to follow modification of spindle characteristics as a function of sleep depth and inter-subjects variability. The algorithm has been applied to physiological data recorded by a high density EEG in order to perform a validation based on visual inspection and on evaluation of expected results from normal night sleep in healthy subjects.

  9. Development in High-Density Cobra Fiber Positioners for the Subaru Telescope's Prime Focus Spectrometer

    Science.gov (United States)

    Fisher, Charles D.; Braun, David F.; Kaluzny, Joel V.; Seiffert, Mic D.; Dekany, Richard G.; Ellis, Richard S.; Smith, Roger S.

    2012-01-01

    The Prime Focus Spectrograph (PFS) is a fiber fed multi-object spectrometer for the Subaru Telescope that will conduct a variety of targeted surveys for studies of dark energy, galaxy evolution, and galactic archaeology. The key to the instrument is a high density array of fiber positioners placed at the prime focus of the Subaru Telescope. The system, nicknamed "Cobra", will be capable of rapidly reconfiguring the array of 2394 optical fibers to the image positions of astronomical targets in the focal plane with high accuracy. The system uses 2394 individual "SCARA robot" mechanisms that are 7.7mm in diameter and use 2 piezo-electric rotary motors to individually position each of the optical fibers within its patrol region. Testing demonstrates that the Cobra positioner can be moved to within 5 micrometers of an astronomical target in 6 move iterations with a success rate of 95%. The Cobra system is a key aspect of PFS that will enable its unprecedented combination of high-multiplex factor and observing efficiency on the Subaru telescope. The requirements, design, and prototyping efforts for the fiber positioner system for the PFS are described here as are the plans for modular construction, assembly, integration, functional testing, and performance validation.

  10. HIGH DENSITY AERIAL IMAGE MATCHING: STATE-OF-THE-ART AND FUTURE PROSPECTS

    Directory of Open Access Journals (Sweden)

    N. Haala

    2016-06-01

    Full Text Available Ongoing innovations in matching algorithms are continuously improving the quality of geometric surface representations generated automatically from aerial images. This development motivated the launch of the joint ISPRS/EuroSDR project “Benchmark on High Density Aerial Image Matching”, which aims on the evaluation of photogrammetric 3D data capture in view of the current developments in dense multi-view stereo-image matching. Originally, the test aimed on image based DSM computation from conventional aerial image flights for different landuse and image block configurations. The second phase then put an additional focus on high quality, high resolution 3D geometric data capture in complex urban areas. This includes both the extension of the test scenario to oblique aerial image flights as well as the generation of filtered point clouds as additional output of the respective multi-view reconstruction. The paper uses the preliminary outcomes of the benchmark to demonstrate the state-of-the-art in airborne image matching with a special focus of high quality geometric data capture in urban scenarios.

  11. Effect of Modified and Nonmodified Carbon Nanotubes on the Rheological Behavior of High Density Polyethylene Nanocomposite

    Directory of Open Access Journals (Sweden)

    Adewunmi A. Ahmad

    2013-01-01

    Full Text Available This paper reports the results of studies on the rheological behavior of nanocomposites of high density polyethylene (HDPE with pristine multiwall carbon nanotubes (CNT as well as phenol and 1-octadecanol (C18 functionalized CNT at 1, 2, 3, 4, 5, and 7 wt% loading. The viscosity reduction at 1 wt% CNT follows the order, pristine CNT < phenol functionalized CNT < C18 functionalized CNT. As the filler loading increases from 1 to 2, 3, and 4 wt%, neat HDPE and filled HDPE systems show similar moduli and viscosity, particularly in the low frequency region. As the filler loading increases further to 5 and 7 wt%, the viscosity and moduli become greater than the neat HDPE. The storage modulus, tan, and the Cole-Cole plots show that CNT network formation occurs at higher CNT loading. The critical CNT loading or the rheological percolation threshold, where network formation occurs is found to be strongly dependant on the functionalization of CNT. For pristine CNT, the rheological percolation threshold is around 4 wt%, but for functionalized CNT it is around 7 wt%. The surface morphologies of CNT and functionalized CNT at 1 wt% loading showed good dispersion while at 7 wt% loading, dispersion was also achieved, but there are few regions with agglomeration of CNT.

  12. Post occupancy evaluation of energy-efficient behavior in informal housing of high density area

    Science.gov (United States)

    Aulia, D. N.; Marpaung, B. O. Y.

    2018-02-01

    The concept of energy-efficient building emphasizes the critical of efficiency in the use of water, electrical energy, and building materials, beginning with design, construction, to the maintenance of the building in the future. This study was conducted to observe the behavior of Energy Saving of the residents in performing everyday activities in the building. The observed variables are the consumption of natural resources (energy, material, water, and land) and the emissions of air, water, and land related to the environment and health. This research is a descriptive qualitative research with the method of data collection is the distribution of questionnaires and observation. The method of analyzing data is posted occupancy evaluation undertaken to obtain patterns of community-based behavior in urban areas. The informal high-density housing area is a typology of population settlements that found in many big cities in Indonesia. This community represents various community groups regarding occupation, education, income, and race. The results of the study concluded that there are five components of energy-saving behavioral formers in housing namely: residential building components, environmental components in occupancy, external occupancy components, components of social activities and elements of business

  13. High-Density Polyethylene and Heat-Treated Bamboo Fiber Composites: Nonisothermal Crystallization Properties

    Directory of Open Access Journals (Sweden)

    Yanjun Li

    2015-01-01

    Full Text Available The effect of heat-treated bamboo fibers (BFs on nonisothermal crystallization of high-density polyethylene (HDPE was investigated using differential scanning calorimetry under nitrogen. The Avrami-Jeziorny model was used to fit the measured crystallization data of the HDPE/BF composites and to obtain the model parameters for the crystallization process. The heat flow curves of neat HDPE and HDPE/heat-treated BF composites showed similar trends. Their crystallization mostly occurred within a temperature range between 379 K and 399 K, where HDPE turned from the liquid phase into the crystalline phase. Values of the Avrami exponent (n were in the range of 2.8~3.38. Lamellae of neat HDPE and their composites grew in a three-dimensional manner, which increased with increased heat-treatment temperature and could be attributed to the improved ability of heterogeneous nucleation and crystallization completeness. The values of the modified kinetic rate constant (KJ first increased and then decreased with increased cooling rate because the supercooling was improved by the increased number of nucleating sites. Heat-treated BF and/or a coupling agent could act as a nucleator for the crystallization of HDPE.

  14. High-Density LiDAR Mapping of the Ancient City of Mayapán

    Directory of Open Access Journals (Sweden)

    Timothy Hare

    2014-09-01

    Full Text Available A 2013 survey of a 40 square kilometer area surrounding Mayapán, Yucatan, Mexico used high-density LiDAR data to map prehispanic architecture and related natural features. Most of the area is covered by low canopy dense forest vegetation over karstic hilly terrain that impedes full coverage archaeological survey. We used LiDAR at 40 laser points per square meter to generate a bare earth digital elevation model (DEM. Results were evaluated with comparisons to previously mapped areas and with traditional archaeological survey methods for 38 settlement clusters outside of the city wall. Ground checking employed full coverage survey of selected 500 m grid squares, as well as documentation of the chronology and detail of new public and domestic settlement features and cenotes. Results identify the full extent of continued, contemporary Postclassic settlement (A.D. 1150–1450 outside of the city wall to at least 500 meters to the east, north, and west. New data also reveal an extensive modified landscape of terraformed residential hills, rejolladas, and dense settlement dating from Preclassic through Classic Periods. The LiDAR data also allow for the identification of rooms, benches, and stone property walls and lanes within the city.

  15. PORTSMOUTH ON-SITE DISPOSAL CELL HIGH DENSITY POLYETHYLENE GEOMEMBRANE LONGEVITY

    Energy Technology Data Exchange (ETDEWEB)

    Phifer, M.

    2012-01-31

    It is anticipated that high density polyethylene (HDPE) geomembranes will be utilized within the liner and closure cap of the proposed On-Site Disposal Cell (OSDC) at the Portsmouth Gaseous Diffusion Plant. The likely longevity (i.e. service life) of HDPE geomembranes in OSDC service is evaluated within the following sections of this report: (1) Section 2.0 provides an overview of HDPE geomembranes, (2) Section 3.0 outlines potential HDPE geomembranes degradation mechanisms, (3) Section 4.0 evaluates the applicability of HDPE geomembrane degradation mechanisms to the Portsmouth OSDC, (4) Section 5.0 provides a discussion of the current state of knowledge relative to the longevity (service life) of HDPE geomembranes, including the relation of this knowledge to the Portsmouth OSDC, and (5) Section 6.0 provides summary and conclusions relative to the anticipated service life of HDPE geomembranes in OSDC service. Based upon this evaluation it is anticipated that the service life of HDPE geomembranes in OSDC service would be significantly greater than the 200 year service life assumed for the OSDC closure cap and liner HDPE geomembranes. That is, a 200 year OSDC HDPE geomembrane service life is considered a conservative assumption.

  16. Positive ion species in high-density discharges containing chlorine and boron endash trichloride

    International Nuclear Information System (INIS)

    Woodworth, J.R.; Nichols, C.A.; Hamilton, T.W.

    1998-01-01

    We have used a quadrupole mass spectrometer to measure the positive ion species striking the wafer in a high-density plasma processing discharge containing chlorine and boron endash trichloride. Since the relative transmission of our mass spectrometer versus ion mass is known, we are able to report the relative concentrations of the ion species striking the wafer. Our measurements were made in an inductively coupled Gaseous Electronics Conference Reference Cell operating at pressures between 15 and 50 mTorr and at electron densities up to 10 11 /cm 3 . The ion spectrum in these discharges is normally dominated by Cl + , Cl 2 + , BCl 2 + , and etch products. However, reactor wall or wafer surface conditions can strongly affect the ion species in the discharge. When a stainless steel open-quotes waferclose quotes was replaced with a bare Si wafer, the dominant chlorine ion changed from Cl + to Cl 2 + . A bare aluminum wafer strongly quenched both Cl + and Cl 2 + signals. copyright 1998 American Vacuum Society

  17. Product distribution modelling in the thermal pyrolysis of high density polyethylene

    International Nuclear Information System (INIS)

    Elordi, G.; Lopez, G.; Olazar, M.; Aguado, R.; Bilbao, J.

    2007-01-01

    The thermal fast pyrolysis of high density polyethylene (HDPE) has been carried out in a conical spouted bed reactor in the 450-715 deg. C range, and individual products have been monitored with the aim of obtaining kinetic data for the design and simulation of this process at large scale. Kinetic schemes have been proposed in order to explain both the results obtained in the laboratory plant and those obtained in the literature by other authors operating at laboratory and larger scale. Discrimination has been carried out based on the contribution of the variance of model parameters (stepwise regression) to the total variance explained by the model. The models based on that of Westerhout et al. [R.W.J. Westerhout, J. Waanders, W.P.M. Van Swaaij, Recycling of polyethene and polypropene in a novel bench-scale rotating cone reactor by high-temperature pyrolysis. Ind. Eng. Chem. Res. 37 (6) (1998) 2293-2300] do not adequately predict the experimental results, especially those corresponding to aromatics and char, which is probably due to the very short residence times attained in the conical spouted bed and, consequently, to the lower yields of aromatics and char. The model of best fit is the one where polyethylene degrades to give gas, liquid (oil) and wax fractions. Furthermore, the latter undergoes secondary reactions to give liquid and aromatics, which in turn produce more char

  18. Non-volatile, high density, high speed, Micromagnet-Hall effect Random Access Memory (MHRAM)

    Science.gov (United States)

    Wu, Jiin C.; Katti, Romney R.; Stadler, Henry L.

    1991-01-01

    The micromagnetic Hall effect random access memory (MHRAM) has the potential of replacing ROMs, EPROMs, EEPROMs, and SRAMs because of its ability to achieve non-volatility, radiation hardness, high density, and fast access times, simultaneously. Information is stored magnetically in small magnetic elements (micromagnets), allowing unlimited data retention time, unlimited numbers of rewrite cycles, and inherent radiation hardness and SEU immunity, making the MHRAM suitable for ground based as well as spaceflight applications. The MHRAM device design is not affected by areal property fluctuations in the micromagnet, so high operating margins and high yield can be achieved in large scale integrated circuit (IC) fabrication. The MHRAM has short access times (less than 100 nsec). Write access time is short because on-chip transistors are used to gate current quickly, and magnetization reversal in the micromagnet can occur in a matter of a few nanoseconds. Read access time is short because the high electron mobility sensor (InAs or InSb) produces a large signal voltage in response to the fringing magnetic field from the micromagnet. High storage density is achieved since a unit cell consists only of two transistors and one micromagnet Hall effect element. By comparison, a DRAM unit cell has one transistor and one capacitor, and a SRAM unit cell has six transistors.

  19. Scalable Sub-micron Patterning of Organic Materials Toward High Density Soft Electronics.

    Science.gov (United States)

    Kim, Jaekyun; Kim, Myung-Gil; Kim, Jaehyun; Jo, Sangho; Kang, Jingu; Jo, Jeong-Wan; Lee, Woobin; Hwang, Chahwan; Moon, Juhyuk; Yang, Lin; Kim, Yun-Hi; Noh, Yong-Young; Jaung, Jae Yun; Kim, Yong-Hoon; Park, Sung Kyu

    2015-09-28

    The success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array, and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability, and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. The successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.

  20. Correlation between the High Density Lipoprotein and its Subtypes in Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Fen Gao

    2016-05-01

    Full Text Available Background/Aims: To detect the changes of high density lipoprotein (HDL and its subtypes in serum of patients with coronary heart disease (CHD. Methods: 337 hospitalized patients were selected from our hospital during August, 2014 - January, 2015, and divided into CHD group (n = 190 and control group (n = 127. Lipoprint lipoprotein analyzer was used to classify low density lipoprotein (LDL particle size and its sub-components, as well as HDL particle size and its sub-components. The changes of the subtypes in patients with CHD were statistically analyzed. The possible mechanism was explored. Results: (1 Compared with the control group, the concentration of HDL in CHD patients reduced, HDLL significantly decreased (P S increased (P L had the most significant decreased; (3 HDL and all HDL subtypes were positively correlated with apolipoprotein A-I (apoA-I, of which, HDLL had the biggest correlation with apoA-I (P M had a maximum correlation with HDL (P Conclusion: HDL maturation disorders existed in the serum of CHD patients, HDLL may be protected factor for CHD, whose decrease was closely related wit the risk increase of CHD. The cardiovascular protection function of HDLL may be related with apoA-I content.

  1. Long term stability of paraoxonase-1 and high-density lipoprotein in human serum

    Directory of Open Access Journals (Sweden)

    Beekhof Piet K

    2012-05-01

    Full Text Available Abstract Background Paraoxonase-1 (PON1 is an enzyme with numerous functions and receives an increasing interest in clinical and epidemiological studies. Sometimes samples are stored for longer periods at a certain temperature. Therefore the stability of PON1 activity must be checked and retained upon storage for longer periods. Results In this study the stability of PON1 activity has been tested in human serum samples during storage up to 12 months at 3 commonly used temperatures, -20°C, -70°C and −196°C. It was found that the stability of the PON1 activity is constant during 12 months of storage at −70°C and −196°C. Storage at −20°C resulted in a small but statistically significant decrease after 6 months to about 94% of its original value. Nonetheless, the rank order between the samples at T = 0 and 12 months remained the same. The same temperature dependence was found for the associated high-density lipoprotein. Conclusions It can be concluded that −70°C is the right temperature for storage to maintain the PON1 activity for at least one year. Storage at a lower temperature in liquid nitrogen (−196°C is not necessary.

  2. Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray.

    Science.gov (United States)

    Ramirez, Lisa S; Wang, Jun

    2016-01-06

    Antibody microarray as a well-developed technology is currently challenged by a few other established or emerging high-throughput technologies. In this report, we renovate the antibody microarray technology by using a novel approach for manufacturing and by introducing new features. The fabrication of our high-density antibody microarray is accomplished through perpendicularly oriented flow-patterning of single stranded DNAs and subsequent conversion mediated by DNA-antibody conjugates. This protocol outlines the critical steps in flow-patterning DNA, producing and purifying DNA-antibody conjugates, and assessing the quality of the fabricated microarray. The uniformity and sensitivity are comparable with conventional microarrays, while our microarray fabrication does not require the assistance of an array printer and can be performed in most research laboratories. The other major advantage is that the size of our microarray units is 10 times smaller than that of printed arrays, offering the unique capability of analyzing functional proteins from single cells when interfacing with generic microchip designs. This barcode technology can be widely employed in biomarker detection, cell signaling studies, tissue engineering, and a variety of clinical applications.

  3. Effect of apolipoprotein E-free high density lipoproteins on cholesterol metabolism in cultured pig hepatocytes

    International Nuclear Information System (INIS)

    Bachorik, P.S.; Virgil, D.G.; Kwiterovich, P.O. Jr.

    1987-01-01

    We studied cholesterol synthesis from [ 14 C]acetate, cholesterol esterification from [ 14 C]oleate, and cellular cholesterol and cholesteryl ester levels after incubating cells with apoE-free high density lipoproteins (HDL) or low density lipoproteins (LDL). LDL suppressed synthesis by up to 60%, stimulated esterification by up to 280%, and increased cell cholesteryl ester content about 4-fold. Esterification increased within 2 h, but synthesis was not suppressed until after 6 h. ApoE-free HDL suppressed esterification by about 50% within 2 h. Cholesterol synthesis was changed very little within 6 h, unless esterification was maximally suppressed; synthesis was then stimulated about 4-fold. HDL lowered cellular unesterified cholesterol by 13-20% within 2 h and promoted the removal of newly synthesized cholesterol and cholesteryl esters. These changes were transient; by 24 h, both esterification and cellular unesterified cholesterol returned to control levels, and cholesteryl esters increased 2-3-fold. HDL core lipid was taken up selectively from 125 I-labeled [ 3 H]cholesteryl ester- and ether-labeled HDL. LDL core lipid uptake was proportional to LDL apoprotein uptake. The findings suggest that 1) the cells respond initially to HDL or LDL with changes in esterification, and 2) HDL mediates both the removal of free cholesterol from the cell and the delivery of HDL cholesteryl esters to the cell

  4. High-Density Plasma-Induced Etch Damage of GaN

    International Nuclear Information System (INIS)

    Baca, A.G.; Han, J.; Lester, L.F.; Pearton, S.J.; Ren, F.; Shul, R.J.; Willison, C.G.; Zhang, L.; Zolper, J.C.

    1999-01-01

    Anisotropic, smooth etching of the group-III nitrides has been reported at relatively high rates in high-density plasma etch systems. However, such etch results are often obtained under high de-bias and/or high plasma flux conditions where plasma induced damage can be significant. Despite the fact that the group-III nitrides have higher bonding energies than more conventional III-V compounds, plasma-induced etch damage is still a concern. Attempts to minimize such damage by reducing the ion energy or increasing the chemical activity in the plasma often result in a loss of etch rate or anisotropy which significantly limits critical dimensions and reduces the utility of the process for device applications requiring vertical etch profiles. It is therefore necessary to develop plasma etch processes which couple anisotropy for critical dimension and sidewall profile control and high etch rates with low-damage for optimum device performance. In this study we report changes in sheet resistance and contact resistance for n- and p-type GaN samples exposed to an Ar inductively coupled plasma (ICP). In general, plasma-induced damage was more sensitive to ion bombardment energies as compared to plasma flux. In addition, p-GaN was typically more sensitive to plasma-induced damage as compared to n-GaN

  5. Normalised Mutual Information of High-Density Surface Electromyography during Muscle Fatigue

    Directory of Open Access Journals (Sweden)

    Adrian Bingham

    2017-12-01

    Full Text Available This study has developed a technique for identifying the presence of muscle fatigue based on the spatial changes of the normalised mutual information (NMI between multiple high density surface electromyography (HD-sEMG channels. Muscle fatigue in the tibialis anterior (TA during isometric contractions at 40% and 80% maximum voluntary contraction levels was investigated in ten healthy participants (Age range: 21 to 35 years; Mean age = 26 years; Male = 4, Female = 6. HD-sEMG was used to record 64 channels of sEMG using a 16 by 4 electrode array placed over the TA. The NMI of each electrode with every other electrode was calculated to form an NMI distribution for each electrode. The total NMI for each electrode (the summation of the electrode’s NMI distribution highlighted regions of high dependence in the electrode array and was observed to increase as the muscle fatigued. To summarise this increase, a function, M(k, was defined and was found to be significantly affected by fatigue and not by contraction force. The technique discussed in this study has overcome issues regarding electrode placement and was used to investigate how the dependences between sEMG signals within the same muscle change spatially during fatigue.

  6. Processing and Characterization of High Density Polyethylene/Ethylene Vinyl Acetate Blends with Different VA Contents

    Directory of Open Access Journals (Sweden)

    Othman Y. Alothman

    2012-01-01

    Full Text Available Different series of high density Polyethylene/Ethylene Vinyl Acetate (HDPE/EVA blends were prepared via melt blending in a corotating intermeshing twin screw extruder. The effects of VA percentage and EVA loading ratio on the thermal, rheological viscoelastic, mechanical, and fracture toughness of the blends were analyzed. The results showed that the addition of EVA to HDPE reduces the thermal, elastic, and viscoelastic properties of the blends. The microscopic examination of the fracture surface confirmed the ductile fracture of HDPE/EVA blends for all blend ratios and VA percentages. Increasing the EVA ratio and VA content caused a significant reduction in the blend crystallinity but had no significant effect on melting temperature. The complex viscosity increased with increasing the percentage of EVA due to the restriction of molecular mobility and reduction of free volume, induced by the addition of EVA. The storage modulus decreased with increasing the EVA ratio and temperature, while it increased with increasing the frequency. Young’s modulus, yield strength, and fracture strain decreased with increasing the EVA ratio. Similarly, the fracture toughness decreased proportional to the EVA percentage. Finally the results indicated that the VA content has significant effects on the mechanical, thermal, and dynamic properties of HDPE/EVA blends.

  7. Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein

    Directory of Open Access Journals (Sweden)

    Maryam Boshtam

    2013-01-01

    Full Text Available Introduction. Cardioprotective effect of high density lipoprotein (HDL is, in part, dependent on its related enzyme, paraoxonase 1 (PON1. Fatty acid composition of HDL could affect its size and structure. On the other hand, PON1 activity is directly related to the structure of HDL. This study was designed to investigate the association between serum PON1 activity and fatty acid composition of HDL in healthy men. Methods. One hundred and forty healthy men participated in this research. HDL was separated by sequential ultracentrifugation, and its fatty acid composition was analyzed by gas chromatography. PON1 activity was measured spectrophotometrically using paraxon as substrate. Results. Serum PON1 activity was directly correlated with the amount of stearic acid and dihomo-gamma-linolenic acid (DGLA. PON1/HDL-C was directly correlated with the amount of miristic acid, stearic acid, and DGLA and was inversely correlated with total amount of ω6 fatty acids of HDL. Conclusion. The fatty acid composition of HDL could affect the activity of its associated enzyme, PON1. As dietary fats are the major determinants of serum lipids and lipoprotein composition, consuming some special dietary fatty acids may improve the activity of PON1 and thereby have beneficial effects on health.

  8. Thermal Treatment of Melt-Spun Fibers Based on High Density PolyEthylene and Lignin

    Directory of Open Access Journals (Sweden)

    Panagiotis Goulis

    2017-11-01

    Full Text Available The purpose of this study was the synthesis of novel low-cost carbon fibers along with the investigation of the optimal parameters of temperature and time for the stabilization of hybrid high-density polyethylene (HDPE and lignin melt-spun fibers. These fibers were manufactured by physical compounding of HDPE and chemically-modified softwood kraft lignin (SKL in order to produce green fiber precursors for carbon fiber synthesis. Stabilization tests were performed with respect to thermal treatment (physical method and sulfonation treatment (chemical method. The results revealed that only chemical methods induce the desired thermal process-ability to the composite fibers in order to manufacture carbon fibers by using a simple method. This investigation shed light on the stabilization techniques of polymeric fibers in the absence of any cyclic groups in terms of environmentally-friendly mass production of carbon fibers using low-cost and green raw materials. This study facilitates incorporation of softwood lignin in homegrown polymeric fibers by a low-cost production process via melt-spinning of composite fibers, which were successfully stabilized using a facile chemical method and carbonized. Additionally, a comprehensive investigation of the thermal behavior of the samples was accomplished, by examining several ways and aspects of fiber thermal treating. The properties of all studied fibers are presented, compared, and discussed.

  9. Soft-x-ray and x-ray ultraviolet radiation from high-density aluminum plasmas

    International Nuclear Information System (INIS)

    Duston, D.; Davis, J.

    1981-01-01

    Radiation emission over a wide range (5--5000 A) of wavelengths in a high-density aluminum plasma has been studied theoretically. The atomic model includes explicit treatment of a large number of states and transitions characterizing the line emission from the Al III--Al XIII ions. The state populations are calculated using a set of atomic rate equations describing a plasma in collisional-radiative equilibrium. The ionization state of the plasma is calculated self-consistently with line and continuum radiation transport using a one-dimensional multicell structure for the plasma. A new radiation transport scheme has been implemented in this model based on probability of escape for both line and continuum photons. The total L- and K-shell radiation emission is described as a function of plasma temperature, density, and source size, and is compared to predictions made from corona and local thermodynamic equilibrium models. It is shown that over a wide range of plasma parameters, neither of these two limiting models accurately describes the plasma emission characteristics. Several line intensity ratios from L-shell lines are studied and shown to be useful diagnostic indicators of the plasma temperature and density. Finally, theoretical spectra are calculated and discussed in the context of their comparability with experimental spectra in order to make contact with real plasma radiation signatures and exploit the predictive capabilities of the model

  10. Yield gains of coffee plants from phosphorus fertilization may not be generalized for high density planting

    Directory of Open Access Journals (Sweden)

    Samuel Vasconcelos Valadares

    2014-06-01

    Full Text Available Inconclusive responses of the adult coffee plant to phosphorus fertilization have been reported in the literature, especially when dealing with application of this nutrient in high density planting systems. Thus, this study was carried out for the purpose of assessing the response of adult coffee plants at high planting density in full production (in regard to yield and their biennial cycle/stability to the addition of different sources and application rates of P in the Zona da Mata region of Minas Gerais, Brazil. The experiment with coffee plants of the Catucaí Amarelo 6/30 variety was carried out over four growing seasons. Treatments were arranged in a full factorial design [(4 × 3 + 1] consisting of four P sources (monoammonium phosphate, simple superphosphate, natural reactive rock phosphate from Algeria (Djebel-Onk, and FH 550®, three P rates (100, 200, and 400 kg ha-1 year-1 of P2O5, and an additional treatment without application of the nutrient (0 kg ha-¹ year-¹. A randomized block experimental design was used with three replicates. The four seasons were evaluated as subplots in a split plot experiment. The P contents in soil and leaves increased with increased rates of P application. However, there was no effect from P application on the yield and its biennial cycle/stability regardless of the source used over the four seasons assessed.

  11. Diagnosing the high density FRX-L Field Reversed Configuration plasma

    Science.gov (United States)

    Wurden, G. A.; Intrator, T. P.; Renneke, R. M.; Dorf, L. A.; Farrell, M. W.; Gray, T. K.; Hsu, S. C.; Lynn, A. G.; Ruden, E. L.

    2006-10-01

    The FRX-L plasma is a high pressure, high density, field reversed configuration (FRC), at n ˜1x10^16-1x10^17 cm-3, and hundreds of eV electron temperature. In order to study formation, equilibrium, transport, flow, and confinement issues, we have a suite of diagnostics. Standard plasma diagnostics include B-dot probes, magnetic flux loops, single and multi-channel visible spectroscopy, optical light tomography arrays, up to 8 filtered visible fibers (546 nm or 486 nm) and an 8-chord side-on HeNe interferometer. Recent diagnostic additions include AXUV bolometers, VUV spectroscopy using a methly salicylate fluorescer converter and optical multichannel analyzer (OMA), eight simultaneous axial views of visible spectra with a 0.3 meter spectrometer and Princeton Instruments PI-Max camera, two-foil end-on surface barrier diode soft x-ray measurements, a hard x-ray/neutron plastic scintillator/ PMT, and indium activation foils to detect time-integrated absolute DD neutron emission. We also discuss plans for a soft x-ray framing camera, using end-on optical access and consisting of a pinhole/fluorescer geometry coupled to a high resolution DiCam camera.

  12. A high-density EEG investigation into steady state binaural beat stimulation.

    Science.gov (United States)

    Goodin, Peter; Ciorciari, Joseph; Baker, Kate; Carey, Anne-Marie; Carrey, Anne-Marie; Harper, Michelle; Kaufman, Jordy

    2012-01-01

    Binaural beats are an auditory phenomenon that has been suggested to alter physiological and cognitive processes including vigilance and brainwave entrainment. Some personality traits measured by the NEO Five Factor Model have been found to alter entrainment using pulsing light stimuli, but as yet no studies have examined if this occurs using steady state presentation of binaural beats for a relatively short presentation of two minutes. This study aimed to examine if binaural beat stimulation altered vigilance or cortical frequencies and if personality traits were involved. Thirty-one participants were played binaural beat stimuli designed to elicit a response at either the Theta (7 Hz) or Beta (16 Hz) frequency bands while undertaking a zero-back vigilance task. EEG was recorded from a high-density electrode cap. No significant differences were found in vigilance or cortical frequency power during binaural beat stimulation compared to a white noise control period. Furthermore, no significant relationships were detected between the above and the Big Five personality traits. This suggests a short presentation of steady state binaural beats are not sufficient to alter vigilance or entrain cortical frequencies at the two bands examined and that certain personality traits were not more susceptible than others.

  13. A moving finite element model of the high density z-pinch

    International Nuclear Information System (INIS)

    Glasser, A.H.

    1989-01-01

    This paper presents the results of computations of the behavior of the fiber-initiated high density Z-pinch (HDZP). It purpose is twofold. One is to study the behavior of the physical system itself as an interesting controlled fusion experiment. The main result of this study is a demonstration of the relaxation of the full inertial behavior of the pinch to simplified self-similar behavior in which the forces on the system are in near balance. The moving free boundary and violent initial behavior of this configuration require carful treatment. This leads to the other purpose of the work, to use this realistic physical system as a test-bed for a general-purpose 1-dimensional code based on moving finite elements. A key step in accomplishing this goal has been the recognition that numerical stability of the discretized equations has required the use of nonconservative quantities as the fundamental dependent variables to be discretized. The main result of this work is a code which is capable of treating a very general class of nonlinear, time-dependent fluid equations. copyright 1989 Academic Press, Inc

  14. HIGH-DENSITY, BIO-COMPATIBLE, AND HERMETIC ELECTRICAL FEEDTHROUGHS USING EXTRUDED METAL VIAS

    Energy Technology Data Exchange (ETDEWEB)

    Shah, K G; Delima, T; Felix, S; Sheth, H; Tolosa, V; Tooker, A; Pannu, S S

    2012-03-28

    Implanted medical devices such as pacemakers and neural prosthetics require that the electronic components that power these devices are protected from the harsh chemical and biological environment of the body. Typically, the electronics are hermetically sealed inside a bio-compatible package containing feedthroughs that transmit electrical signals, while being impermeable to particles or moisture. We present a novel approach for fabricating one of the highest densities of biocompatible hermetic feedthroughs in alumina (Al{sub 2}O{sub 3}). Alumina substrates with laser machined vias of 200 {micro}m pitch were conformally metallized and lithographically patterned. Hermetic electrical feedthroughs were formed by extruding metal stud-bumps partially through the vias. Hermeticity testing showed leak rates better than 9 x 10{sup -10} torr-l/s. Based on our preliminary results and process optimization, this extruded metal via approach is a high-density, low temperature, cost-effective, and robust method of miniaturizing electrical feedthroughs for a wide range of implantable bio-medical device applications.

  15. HIGH-DENSITY, BIO-COMPATIBLE, AND HERMETIC ELECTRICAL FEEDTHROUGHS USING EXTRUDED METAL VIAS

    Energy Technology Data Exchange (ETDEWEB)

    Tooker, A; Shah, K; Tolosa, V; Sheth, H; Felix, S; Delima, T; Pannu, S

    2012-03-29

    Implanted medical devices such as pacemakers and neural prosthetics require that the electronic components that power these devices are protected from the harsh chemical and biological environment of the body. Typically, the electronics are hermetically sealed inside a bio-compatible package containing feedthroughs that transmit electrical signals, while being impermeable to particles or moisture. We present a novel approach for fabricating one of the highest densities of biocompatible hermetic feedthroughs in alumina (Al{sub 2}O{sub 3}). Alumina substrates with laser machined vias of 200 {mu}m pitch were conformally metallized and lithographically patterned. Hermetic electrical feedthroughs were formed by extruding metal studbumps partially through the vias. Hermeticity testing showed leak rates better than 9x10{sup -10} torr-l/s. Based on our preliminary results and process optimization, this extruded metal via approach is a high-density, low temperature, cost-effective, and robust method of miniaturizing electrical feedthroughs for a wide range of implantable bio-medical device applications.

  16. [Alterations in the protein content and dysfunction of high-density lipoproteins from hyperhomocysteinemic mice].

    Science.gov (United States)

    Julve, Josep; Errico, Teresa Laura; Chen, Xiangyu; Santos, David; Freixa, Júlia; Porcel, Inmaculada; Cubero, Esther; Escolà-Gil, Joan Carles; Blanco-Vaca, Francisco

    2013-01-01

    The aim of this study was to evaluate the proteic changes in high-density lipoproteins (HDL) induced by methionine-induced hyperhomocysteinemia in mice and its relationship with two of their main antiatherogenic properties. The oral administration of methionine resulted in an elevation (~8 times) in the plasma concentration of homocysteine. Hyperhomocysteinemia was inversely correlated with the plasma concentration of HDL cholesterol and its main protein component of HDL, apolipoprotein (apo) A-I, respectively. The cholesterol efflux in vivo from macrophages to HDL was decreased in hyperhomocysteinemic mice compared with the control mice. However, the reverse cholesterol transport from macrophages to feces remained unchanged. On the other hand, the ability of HDL from hyperhomocysteinemic mice to prevent the oxidative modification of low-density lipoproteins (LDL) was found decreased and associated with a concomitant reduction in the plasma activity of paraoxonase-1 (PON1) and the plasma concentration of apoA-I, and with a relative reduction in the apoA-IV content (~1.5 times) in the hyperhomocysteinemic HDL, respectively. The decrease in the ability of HDL from hyperhomocysteinemic mice to prevent LDL from oxidation was associated with a decrease in the apoA-I, PON1 and apoA-IV. Copyright © 2013 Elsevier España, S.L. and SEA. All rights reserved.

  17. Development of bioprocess for high density cultivation yield of the probiotic Bacillus coagulans and its spores

    Directory of Open Access Journals (Sweden)

    Kavita R. Pandey

    2016-09-01

    Full Text Available Bacillus coagulans is a spore forming lactic acid bacterium. Spore forming bacteria, have been extensively studied and commercialized as probiotics. Probiotics are produced by fermentation technology. There is a limitation to biomass produced by conventional modes of fermentation. With the great demand generated by range of probiotic products, biomass is becoming very valuable for several pharmaceutical, dairy and probiotic companies. Thus, there is a need to develop high cell density cultivation processes for enhanced biomass accumulation. The bioprocess development was carried out in 6.6 L bench top lab scale fermentor. Four different cultivation strategies were employed to develop a bioprocess for higher growth and sporulation efficiencies of probiotic B. coagulans. Batch fermentation of B. coagulans yielded 18 g L-1 biomass (as against 8.0 g L-1 productivity in shake flask with 60% spore efficiency. Fed-batch cultivation was carried out for glucose, which yielded 25 g L-1 of biomass. C/N ratio was very crucial in achieving higher spore titres. Maximum biomass yield recorded was 30 g L-1, corresponding to 3.8 × 1011 cells mL-1 with 81% of cells in sporulated stage. The yield represents increment of 85 times the productivity and 158 times the spore titres relative to the highest reported values for high density cultivation of B. coagulans.

  18. Durability of a fin-tube latent heat storage using high density polyethylene as PCM

    Science.gov (United States)

    Zauner, Christoph; Hengstberger, Florian; Etzel, Mark; Lager, Daniel; Hofmann, Rene; Walter, Heimo

    2017-10-01

    Polymers have rarely been used as storage materials in latent heat storages up to now. Thus, we systematically screened all polymers available on a large-scale, selected promising ones based on their theoretical properties and experimentally tested more than 50 candidates. We found that polyethylene, polyoxymethylene and polyamides are promising even as recycled material. Especially high density polyethylene (HDPE) turned out to be suitable as was shown by detailed thermophysical characterization including more than 1000 heating and cooling cycles for INEOS Rigidex HD6070EA. We built a storage with 170 kg HDPE and a total mass of 600 kg based on a fin-tube heat exchanger and characterized its energy capacity, power characteristics and temperature profiles using a thermal oil test rig. In total we performed 30 melting and crystallization cycles where the whole storage was above 100 °C for more than 140 hours. After usage we examined the interior of the storage by cutting it into various pieces. A thin layer of degradation was observed on the surfaces of the PCM which is most likely related to thermo-oxidative degeneration of HDPE. However, the bulk of the PCM is still intact as well as the heat exchanger itself.

  19. Visceral adiposity index and triglyceride/high-density lipoprotein cholesterol ratio in hypogonadism.

    Science.gov (United States)

    Haymana, Cem; Sonmez, Alper; Aydogdu, Aydogan; Tapan, Serkan; Basaran, Yalcin; Meric, Coskun; Baskoy, Kamil; Dinc, Mustafa; Yazici, Mahmut; Taslipinar, Abdullah; Barcin, Cem; Yilmaz, Mahmut Ilker; Bolu, Erol; Azal, Omer

    2017-01-01

    Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and independent predictors of cardiaovascular risk. To date, no study has evaluated VAI levels and TG/HDL-C ratio in hypogonadism. A total of 112 patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age, 21.7 ± 2.06 years) and 124 healthy subjects (mean age, 21.5 ± 1.27 years) were enrolled. The demographic parameters, VAI, TG/HDL-C ratio, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants. The patients had higher total cholesterol (p = 0.04), waist circumference, triglycerides, insulin, and HOMA-IR levels (p = 0.001 for all) than the healthy subjects. VAI and ADMA and TG/HDL-C levels were also higher in patients than in healthy subjects (p hypogonadism have elevated VAI and TG/HDL-C ratio. These values are significantly correlated with the surrogate markers of endothelial dysfunction, inflammation, and insulin resistance. However, the predictive roles of VAI and TG/HDL-C ratio are not significant. Prospective follow-up studies are warranted to clarify the role of VAI and TG/HDL-C ratio in predicting cardiometabolic risk in patients with hypogonadism.

  20. High-density carbon ablator experiments on the National Ignition Facilitya)

    Energy Technology Data Exchange (ETDEWEB)

    MacKinnon, A. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Meezan, N. B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ross, J. S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Le Pape, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Berzak Hopkins, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divol, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ho, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Milovich, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pak, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ralph, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Döppner, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Patel, P. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Thomas, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Tommasini, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Haan, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); MacPhee, A. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McNaney, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Caggiano, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hatarik, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bionta, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ma, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Spears, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rygg, J. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Benedetti, L. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Town, R. P. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bradley, D. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dewald, E. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fittinghoff, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Jones, O. S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Robey, H. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Moody, J. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Khan, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Callahan, D. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hamza, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Biener, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Celliers, P. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Braun, D. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Erskine, D. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Prisbrey, S. T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wallace, R. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kozioziemski, B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dylla-Spears, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sater, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Collins, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Storm, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hsing, W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Landen, O. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Atherton, J. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lindl, J. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Edwards, M. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Frenje, J. A. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Gatu-Johnson, M. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Li, C. K. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Petrasso, R. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Rinderknecht, H. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Rosenberg, M. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Séguin, F. H. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Zylstra, A. [MIT (Massachusetts Inst. of Technology), Cambridge, MA (United States); Knauer, J. P. [Univ. of Rochester, NY (United States); Grim, G. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Guler, N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Merrill, F. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olson, R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kyrala, G. A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kilkenny, J. D. [General Atomics, San Diego, CA (United States); Nikroo, A. [General Atomics, San Diego, CA (United States); Moreno, K. [General Atomics, San Diego, CA (United States); Hoover, D. E. [General Atomics, San Diego, CA (United States); Wild, C. [Diamond Materials GmbH, Freiburg (Germany); Werner, E. [Diamond Materials GmbH, Freiburg (Germany)

    2014-05-01

    High Density Carbon (HDC) is a leading candidate as an ablator material for Inertial Confinement Fusion (ICF) capsules in x-ray (indirect) drive implosions. HDC has a higher density (3.5 g/cc) than plastic (CH, 1 g/cc), which results in a thinner ablator with a larger inner radius for a given capsule scale. This leads to higher x-ray absorption and shorter laser pulses compared to equivalent CH designs. This paper will describe a series of experiments carried out to examine the feasibility of using HDC as an ablator using both gas filled hohlraums and lower density, near vacuum hohlraums. These experiments have shown that deuterium (DD) and deuterium-tritium gas filled HDC capsules driven by a hohlraum filled with 1.2 mg/cc He gas, produce neutron yields a factor of 2× higher than equivalent CH implosions, representing better than 50% Yield-over-Clean (YoC). In a near vacuum hohlraum (He = 0.03 mg/cc) with 98% laser-to-hohlraum coupling, such a DD gas-filled capsule performed near 1D expectations. A cryogenic layered implosion version was consistent with a fuel velocity = 410 ± 20 km/s with no observed ablator mixing into the hot spot.

  1. High Density, Insensitive Oxidizer With RDX Performance Final Report CRADA No. TC02178.0

    Energy Technology Data Exchange (ETDEWEB)

    Pagoria, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Preda, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-08-25

    This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Physical Sciences, Inc. (PSI), to develop a synthesis and evaluate a novel high density, insensitive oxidizer with RDX performance. This CRADA resulted from the award of a Phase I STTR ("STTR") from DOD. In recent years, the synthesis of new energetic heterocyclic compounds to replace the energetic materials currently in the stockpile has received a great amount of attention. The Office of the Secretary of Defense has identified that there is a need to incorporate new energetic materials in current and future weapon systems in an effort to increase performance and decrease sensitivity. For many of the future weapon systems, incorporation of energetic compounds currently in the stockpile will not provide the desired performance and sensitivity goals. The success of this CRADA may lead to a Phase I option STTR from DOD and to a Phase II STTR from DOD. The goal of this CRADA was to produce and test a novel oxidizer, 2,5,8-trinitroheptazine (TNH).

  2. Traffic Signal Synchronization in the Saturated High-Density Grid Road Network

    Directory of Open Access Journals (Sweden)

    Xiaojian Hu

    2015-01-01

    Full Text Available Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN. Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR traffic signal synchronization strategy. The essence of the strategy is to control the formation and dissipation of queues and to maximize the efficiency of traffic flows at signalized intersections in the saturated HGRN. With this strategy, the same signal control timing plan is used at all signalized intersections in the HGRN, and the straight phase of the control timing plan has a long green time and a long red time. Therefore, continuous traffic flows can be maintained when vehicles travel, and traffic congestion can be alleviated when vehicles stop. Using the strategy, the LGLR traffic signal synchronization model is developed, with the objective of minimizing the number of stops. Finally, the simulation is executed to analyze the performance of the model by comparing it to other models, and the superiority of the LGLR model is evident in terms of delay, number of stops, queue length, and overall performance in the saturated HGRN.

  3. High density of benzodiazepine binding sites in the substantia innominata of the rat

    Energy Technology Data Exchange (ETDEWEB)

    Sarter, M.; Schneider, H.H.

    1988-07-01

    In order to study the neuronal basis of the pharmacological interactions between benzodiazepine receptor ligands and cortical cholinergic turnover, we examined the regional distribution of specific benzodiazepine binding sites using in vitro autoradiography. In the basal forebrain, the substantia innominata contained a high density of (/sup 3/H)lormetazepam (LMZ) binding sites (Bmax = 277 fmol/mg tissue; Kd = 0.55 nM). The label could be displaced by diazepam (IC50 = 100 nM), the benzodiazepine receptor antagonist beta-carboline ZK 93426 (45 nM) and the partial inverse agonist beta-carboline FG 7142 (540 nM). It is hypothesized that the amnesic effects of benzodiazepine receptor agonists are exerted through benzodiazepine receptors which are situated on cholinergic neurons in the substantia innominata and are involved in a tonic inhibition of cortical acetylcholine release. The benzodiazepine receptor antagonist ZK 93426 may exert its nootropic effects via benzodiazepine receptors in the substantia innominata and, consequently, by disinhibiting cortical acetylcholine release.

  4. Unique Features of High-Density Lipoproteins in the Japanese: In Population and in Genetic Factors

    Directory of Open Access Journals (Sweden)

    Shinji Yokoyama

    2015-04-01

    Full Text Available Despite its gradual increase in the past several decades, the prevalence of atherosclerotic vascular disease is low in Japan. This is largely attributed to difference in lifestyle, especially food and dietary habits, and it may be reflected in certain clinical parameters. Plasma high-density lipoprotein (HDL levels, a strong counter risk for atherosclerosis, are indeed high among the Japanese. Accordingly, lower HDL seems to contribute more to the development of coronary heart disease (CHD than an increase in non-HDL lipoproteins at a population level in Japan. Interestingly, average HDL levels in Japan have increased further in the past two decades, and are markedly higher than in Western populations. The reasons and consequences for public health of this increase are still unknown. Simulation for the efficacy of raising HDL cholesterol predicts a decrease in CHD of 70% in Japan, greater than the extent by reducing low-density lipoprotein cholesterol predicted by simulation or achieved in a statin trial. On the other hand, a substantial portion of hyperalphalipoproteinemic population in Japan is accounted for by genetic deficiency of cholesteryl ester transfer protein (CETP, which is also commonly unique in East Asian populations. It is still controversial whether CETP mutations are antiatherogenic. Hepatic Schistosomiasis is proposed as a potential screening factor for historic accumulation of CETP deficiency in East Asia.

  5. HDPE (High Density Polyethylene) pipeline and riser design in Guanabara Bay: challenges and solutions

    Energy Technology Data Exchange (ETDEWEB)

    Bomfimsilva, Carlos; Jorge, Joao Paulo Carrijo; Schmid, Dominique; Gomes, Rodrigo Klim [INTECSEA, Sao Paulo, SP (Brazil); Lima, Alexander Piraja [GDK, Salvador, BA (Brazil)

    2009-12-19

    Worldwide shipments of plastic pipes are forecasted to increase 5.2% per year since 2008, being commonly used for water supply and sewage disposal. The HDPE (High Density Polyethylene) pipes have been applied recently to deliver potable water and fire fighting water for the main pier of the LNG system in Guanabara Bay, Rio de Janeiro. The system contains three sizes of pipe outside diameter, 110 mm and 160 mm for water supply, and 500 mm for the fire fighting system. The main design challenges of the pipeline system included providing on-bottom stability, a suitable installation procedure and a proper riser design. The on-bottom stability calculations, which are quite different from the conventional steel pipelines, were developed by designing concrete blocks to be assembled on the pipeline in a required spacing to assure long term stability, knowing that plastic pipes are buoyant even in flooded conditions. The installation procedure was developed considering the lay down methodology based on surface towing technique. The riser was designed to be installed together with additional steel support structure to allow the entire underwater system to have the same plastic pipe specification up to the surface. This paper presents the main challenges that were faced during the design of the HDPE pipelines for the LNG system in Guanabara Bay, addressing the solutions and recommendations adopted for the plastic underwater pipeline system.

  6. High density LHCD experiments and recent progress on HT-7 superconducting tokamak

    International Nuclear Information System (INIS)

    2000-01-01

    The quasi-steady state (τ H > 10 τ Eoh ) H-mode was obtained with very high plasma density by Lower Hybrid Current Drive (LHCD). The line average density during improved confinement phase is about 4.5∼6.0x10 13 cm -3 which is very close to the Greenwald density limit (78 ∼ 96% of Greenwald density limit). The τ E is about 1.5 ∼ 2.0 times than the L-mode scaling during H-phase. The experimental results show a good agreement with code simulation for the LH off-axis power deposition profile with a reproducible manner. These off-axis hollow current profiles and enhanced confinement improvements are attributed to a strong reduction of electron thermal diffusivity in the reversed shear region. Steady state full LH wave current drive has been achieved. The pulse length is 3.5 seconds, which reaches the present limit of PF system. The good plasma condition is obtained by ICRF boronization, which makes Z eff close to 1.0. High density shots are obtained by two different fueling methods: multi pellet injection and supersonic beam injection. The later shows a high fueling efficiency that could be used for steady-state operation and the plasma density exceeds the Greenwald density limit. ICRH preionization, start-up, heating and its synergy with LHCD have been tested during recent experiments and some interesting results have been obtained. (author)

  7. [ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].

    Science.gov (United States)

    Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio

    2015-09-01

    high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  8. Traffic Signal Synchronization in the Saturated High-Density Grid Road Network

    Science.gov (United States)

    Hu, Xiaojian; Lu, Jian; Wang, Wei; Zhirui, Ye

    2015-01-01

    Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN). Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR) traffic signal synchronization strategy. The essence of the strategy is to control the formation and dissipation of queues and to maximize the efficiency of traffic flows at signalized intersections in the saturated HGRN. With this strategy, the same signal control timing plan is used at all signalized intersections in the HGRN, and the straight phase of the control timing plan has a long green time and a long red time. Therefore, continuous traffic flows can be maintained when vehicles travel, and traffic congestion can be alleviated when vehicles stop. Using the strategy, the LGLR traffic signal synchronization model is developed, with the objective of minimizing the number of stops. Finally, the simulation is executed to analyze the performance of the model by comparing it to other models, and the superiority of the LGLR model is evident in terms of delay, number of stops, queue length, and overall performance in the saturated HGRN. PMID:25663835

  9. The Relationship between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome.

    Science.gov (United States)

    Shin, Hyun-Gyu; Kim, Young-Kwang; Kim, Yong-Hwan; Jung, Yo-Han; Kang, Hee-Cheol

    2017-11-01

    Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predicts insulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol (LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndrome in the general Korean population. We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and Nutrition Examination Survey in 2013 and 2014. Subjects with angina pectoris, myocardial infarction, stroke, or cancer were excluded. Metabolic syndrome was defined by the harmonized definition. We examined the odds ratios (ORs) of metabolic syndrome according to TG/HDLC ratio quartiles using logistic regression analysis (SAS ver. 9.4; SAS Institute Inc., Cary, NC, USA). Weighted complex sample analysis was also conducted. We found a significant association between the TG/HDLC ratio and metabolic syndrome. The cutoff value of the TG/HDLC ratio for the fourth quartile was ≥3.52. After adjustment, the OR for metabolic syndrome in the fourth quartile compared with that of the first quartile was 29.65 in men and 20.60 in women (Pmetabolic syndrome.

  10. A PROPOSAL OF NITROGEN BALANCE IN A VERY HIGH DENSITY OLIVE ORCHARD.

    Directory of Open Access Journals (Sweden)

    H. Belguerri

    2016-05-01

    Full Text Available The nitrogen (N balance was estimated in a very high density olive orchard in north- east of Spain, in order to calculate the inputs and outputs of N related to tree response and soil nitrogen availability. The calculate N inputs and outputs showed that N exported by yield and pruning material were higher for fertilized plots than unfertilized ones, and no significant differences were recorded for nitrogen mineralization between both treatments. N balance, defined as the difference between inorganic N content in soil at the end and the beginning of each year, was positive for both treatments but when vegetative growth and olive yield were compared, fertilized plots showed  higher values, So it is wrong noting that a positive N balance in both case means that olive tree will provide a peak yield and vegetative growth but  it is an adaptation of  the olive trees to different soil N availability conditions by equilibrating their vegetative growth and fruit yield.   

  11. SNP Discovery and Development of a High-Density Genotyping Array for Sunflower

    Science.gov (United States)

    Bachlava, Eleni; Taylor, Christopher A.; Tang, Shunxue; Bowers, John E.; Mandel, Jennifer R.; Burke, John M.; Knapp, Steven J.

    2012-01-01

    Recent advances in next-generation DNA sequencing technologies have made possible the development of high-throughput SNP genotyping platforms that allow for the simultaneous interrogation of thousands of single-nucleotide polymorphisms (SNPs). Such resources have the potential to facilitate the rapid development of high-density genetic maps, and to enable genome-wide association studies as well as molecular breeding approaches in a variety of taxa. Herein, we describe the development of a SNP genotyping resource for use in sunflower (Helianthus annuus L.). This work involved the development of a reference transcriptome assembly for sunflower, the discovery of thousands of high quality SNPs based on the generation and analysis of ca. 6 Gb of transcriptome re-sequencing data derived from multiple genotypes, the selection of 10,640 SNPs for inclusion in the genotyping array, and the use of the resulting array to screen a diverse panel of sunflower accessions as well as related wild species. The results of this work revealed a high frequency of polymorphic SNPs and relatively high level of cross-species transferability. Indeed, greater than 95% of successful SNP assays revealed polymorphism, and more than 90% of these assays could be successfully transferred to related wild species. Analysis of the polymorphism data revealed patterns of genetic differentiation that were largely congruent with the evolutionary history of sunflower, though the large number of markers allowed for finer resolution than has previously been possible. PMID:22238659

  12. Using Rutile TiO2 Nanoparticles Reinforcing High Density Polyethylene Resin

    Directory of Open Access Journals (Sweden)

    Vu Manh Tuan

    2014-01-01

    Full Text Available The TiO2 nanoparticles were used as a reinforcement to prepare nanocomposites with high density polyethylene (HDPE by melt blending process. The original TiO2 (ORT was modified by 3-glycidoxypropyltrimethoxysilane (GPMS to improve the dispersion into HDPE matrix. The FT-IR spectroscopy and FESEM micrographs of modified TiO2 (GRT demonstrated that GPMS successfully grafted with TiO2 nanoparticles. The tensile test of HDPE/ORT and HDPE/GRT nanocomposites with various contents of dispersive particles indicated that the tensile strength and Young’s modulus of HDPE/GRT nanocomposites are superior to the values of original HDPE and HDPE/ORT nanocomposites. At 1 wt.% of GRT, the mechanical properties of nanocomposites were optimal. In DSC and TGA analyses, with the presence of GRT in the nanocomposites, the thermal stability significantly increased in comparison with pure HDPE and HDPE/ORT nanocomposites. The better dispersion of GRT in polymer matrix as shown in FESEM images demonstrated the higher mechanical properties of HDPE/GRT nanocomposites to HDPE/ORT nanocomposites.

  13. On the sensitivity of dimensional stability of high density polyethylene on heating rate

    Directory of Open Access Journals (Sweden)

    2007-02-01

    Full Text Available Although high density polyethylene (HDPE is one of the most widely used industrial polymers, its application compared to its potential has been limited because of its low dimensional stability particularly at high temperature. Dilatometry test is considered as a method for examining thermal dimensional stability (TDS of the material. In spite of the importance of simulation of TDS of HDPE during dilatometry test it has not been paid attention by other investigators. Thus the main goal of this research is concentrated on simulation of TDS of HDPE. Also it has been tried to validate the simulation results and practical experiments. For this purpose the standard dilatometry test was done on the HDPE speci­mens. Secant coefficient of linear thermal expansion was computed from the test. Then by considering boundary conditions and material properties, dilatometry test has been simulated at different heating rates and the thermal strain versus temper­ature was calculated. The results showed that the simulation results and practical experiments were very close together.

  14. Productive and vegetative behavior of olive cultivars in super high-density olive grove

    Directory of Open Access Journals (Sweden)

    Primo Proietti

    2015-02-01

    Full Text Available In recent years, there has been an increase in interest in super high-density (SHD olive (Olea europaea L. groves because they offer early entry into production, increased productivity and the possibility of using modified mechanical vine harvesters. This study was carried out in a young SHD olive grove to examine vegetative, histo-anatomical and productive characteristics and oil quality of the Spanish Arbequina and Italian Maurino and Leccino cultivars, characterized by low, low-to-medium and high vigor, respectively. Arbequina had low vigor and limited development in height and width, as well as a high leaf/wood ratio. Maurino had a canopy volume similar to that of Arbequina and, despite a great tendency to grow in height, had low vigor, a rather compact vegetative habitus, but good lighting in the canopy and high production efficiency. In Maurino, a greater palisade parenchyma height and a larger exposed lateral surface area of the palisade parenchyma cells were observed. In the fourth year after planting, fruit production of Arbequina was about 30 % less than Leccino and Maurino. The oil content on a dry weight basis was slightly higher in Arbequina and Maurino than in Leccino. Oil quality was good for all cultivars.

  15. High Density Die Casting (HDDC): new frontiers in the manufacturing of heat sinks

    Science.gov (United States)

    Sce, Andrea; Caporale, Lorenzo

    2014-07-01

    Finding a good solution for thermal management problems is every day more complex. due to the power density and the required performances. When a solution suitable for high volumes is needed. die-casting and extrusion are the most convenient technologies. However designers have to face the well-known limitations for those processes. High Density Die Casting (HDDC) is a process under advanced development. in order to overcome the extrusion and traditional die casting limits by working with alloys having much better thermal performances than the traditional die-casting process. while keeping the advantages of a flexible 3D design and a low cost for high volumes. HDDC offers the opportunity to design combining different materials (aluminium and copper. aluminium and stainless steel) obtaining a structure with zero porosity and overcoming some of die-casting limits. as shown in this paper. A dedicated process involving embedded heat pipes is currently under development in order to offer the possibility to dramatically improve the heat spreading.

  16. [Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia].

    Science.gov (United States)

    Figueroa, Catalina; Droppelmann, Katherine; Quiñones, Verónica; Amigo, Ludwig; Mendoza, Camila; Serrano, Valentina; Véjar, Margarita; Maiz, Alberto; Rigotti, Attilio

    2015-09-01

    Plasma high density lipoproteins (HDL) are involved in reverse cholesterol transport mediated by the scavenger receptor class B type I (SR-BI). Nicotinic acid increases HDL cholesterol levels, even though its specific impact on SR-BI dependent-cellular cholesterol transport remains unknown. To determine the effect of nicotinic acid on HDL particle functionality in cholesterol efflux and uptake mediated by SR-BI in cultured cells in hypoalphalipoproteinemic patients. In a pilot study, eight patients with low HDL (≤ 40 mg/dL) were treated with extended release nicotinic acid. HDL cholesterol and phospholipid levels, HDL2 and HDL3 fractions and HDL particle sizes were measured at baseline and post-therapy. Before and after nicotinic acid treatment, HDL particles were used for cholesterol transport studies in cells transfected with SR-BI. Nicotinic acid treatment raised total HDL cholesterol and phospholipids, HDL2 levels as well as HDL particle size. Nicotinic acid significantly increased HDL cholesterol efflux and uptake capacity mediated by SR-BI in cultured cells. Nicotinic acid therapy increases SR-BI-dependent HDL cholesterol transport in cultured cells, establishing a new cellular mechanism by which this lipid-lowering drug appears to modulate HDL metabolism in patients with hypoalphalipoproteinemia.

  17. Characterization of a silica-PVA hybrid for high density and stable silver dissolution

    Energy Technology Data Exchange (ETDEWEB)

    Dorin, Bryce, E-mail: bryce.dorin@postgrad.manchester.ac.uk [The Photon Science Institute, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); School of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); Zhu, Guangyu, E-mail: g.zhu@liverpool.ac.uk [Lairdside Laser Engineering Centre, The University of Liverpool, Campbeltown Road, Merseyside, CH41 9HP (United Kingdom); Parkinson, Patrick, E-mail: patrick.parkinson@manchester.ac.uk [The Photon Science Institute, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); Perrie, Walter, E-mail: wpfemto1@liverpool.ac.uk [Lairdside Laser Engineering Centre, The University of Liverpool, Campbeltown Road, Merseyside, CH41 9HP (United Kingdom); Benyezzar, Med, E-mail: med.benyezzar@manchester.ac.uk [The Photon Science Institute, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); Scully, Patricia, E-mail: patricia.scully@manchester.ac.uk [The Photon Science Institute, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom); School of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Manchester, M13 9PL (United Kingdom)

    2016-07-01

    A silica and polyvinyl alcohol (PVA) hybrid material mixed with a high density of silver ions is synthesised and characterized in this work. The hybrid material can be cast into thick films, which we determined to be homogeneous using Raman spectroscopy. We observed that the silver ions remain stable in the material over time and at temperatures of 100 °C, which represents a marked improvement over previous solid solutions of silver. Differential scanning calorimetry and thermogravimetric analysis indicate the rapid activation of silver at 173 °C, resulting in a dense formation of silver nanoparticles within the hybrid. The activation of silver was also demonstrated in 3-dimensional geometries using femtosecond duration laser pulses. These results illustrate the silica-PVA hybrid is an attractive material for developing silver-insulator composites. - Highlights: • A novel PVA-silica hybrid is developed for silver ion dissolution. • The hybrid exhibits a high silver saturation point and good silver stability. • Heating and laser irradiation are capable of converting the silver ions to metal. • The hybrid material enables the fabrication of 3D metal-insulator composites.

  18. Low-frequency, high-density, inductively coupled plasma sources: Operation and applications

    Science.gov (United States)

    Xu, S.; Ostrikov, K. N.; Li, Y.; Tsakadze, E. L.; Jones, I. R.

    2001-05-01

    Operation regimes, plasma parameters, and applications of the low-frequency (˜500 kHz) inductively coupled plasma (ICP) sources with a planar external coil are investigated. It is shown that highly uniform, high-density (ne˜9×1012 cm-3) plasmas can be produced in low-pressure argon discharges with moderate rf powers. The low-frequency ICP sources operate in either electrostatic (E) or electromagnetic (H) regimes in a wide pressure range without any Faraday shield or an external multipolar magnetic confinement, and exhibit high power transfer efficiency, and low circuit loss. In the H mode, the ICP features high level of uniformity over large processing areas and volumes, low electron temperatures, and plasma potentials. The low-density, highly uniform over the cross-section, plasmas with high electron temperatures and plasma and sheath potentials are characteristic to the electrostatic regime. Both operation regimes offer great potential for various plasma processing applications. As examples, the efficiency of the low-frequency ICP for steel nitriding and plasma-enhanced chemical vapor deposition of hydrogenated diamond-like carbon (DLC) films, is demonstrated. It appears possible to achieve very high nitriding rates and dramatically increase micro-hardness and wear resistance of the AISI 304 stainless steel. It is also shown that the deposition rates and mechanical properties of the DLC films can be efficiently controlled by selecting the discharge operating regime.

  19. Recovery of hydrocarbon liquid from waste high density polyethylene by thermal pyrolysis

    Directory of Open Access Journals (Sweden)

    Sachin Kumar

    2011-12-01

    Full Text Available Thermal degradation of waste plastics in an inert atmosphere has been regarded as a productive method, because this process can convert waste plastics into hydrocarbons that can be used either as fuels or as a source of chemicals. In this work, waste high-density polyethylene (HDPE plastic was chosen as the material for pyrolysis. A simple pyrolysis reactor system has been used to pyrolyse waste HDPE with the objective of optimizing the liquid product yield at a temperature range of 400ºC to 550ºC. Results of pyrolysis experiments showed that, at a temperature of 450ºC and below, the major product of the pyrolysis was oily liquid which became a viscous liquid or waxy solid at temperatures above 475ºC. The yield of the liquid fraction obtained increased with the residence time for waste HDPE. The liquid fractions obtained were analyzed for composition using FTIR and GC-MS. The physical properties of the pyrolytic oil show the presence of a mixture of different fuel fractions such as gasoline, kerosene and diesel in the oil.

  20. A Novel Visualization Method for Sleep Spindles Based on Source Localization of High Density EEG.

    Science.gov (United States)

    Lee, Soohyun; Kim, Seunghwan; Choi, Jee Hyun

    2017-12-01

    Equivalent dipole source localization is a well-established approach to localizing the electrical activity in electroencephalogram (EEG). So far, source localization has been used primarily in localizing the epileptic source in human epileptic patients. Currently, source localization techniques have been applied to account for localizing epileptic source among the epileptic patients. Here, we present the first application of source localization in the field of sleep spindle in mouse brain. The spatial distribution of cortical potential was obtained by high density EEG and then the anterior and posterior sleep spindles were classified based on the K-mean clustering algorithm. To solve the forward problem, a realistic geometry brain model was produced based on boundary element method (BEM) using mouse MRI. Then, we applied four different source estimation algorithms (minimum norm, eLORETA, sLORETA, and LORETA) to estimate the spatial location of equivalent dipole source of sleep spindles. The estimated sources of anterior and posterior spindles were plotted in a cine-mode that revealed different topographic patterns of spindle propagation. The characterization of sleep spindles may be better be distinguished by our novel visualization method.

  1. High Density Polyethylene Composites Reinforced with Hybrid Inorganic Fillers: Morphology, Mechanical and Thermal Expansion Performance.

    Science.gov (United States)

    Huang, Runzhou; Xu, Xinwu; Lee, Sunyoung; Zhang, Yang; Kim, Birm-June; Wu, Qinglin

    2013-09-17

    The effect of individual and combined talc and glass fibers (GFs) on mechanical and thermal expansion performance of the filled high density polyethylene (HDPE) composites was studied. Several published models were adapted to fit the measured tensile modulus and strength of various composite systems. It was shown that the use of silane-modified GFs had a much larger effect in improving mechanical properties and in reducing linear coefficient of thermal expansion (LCTE) values of filled composites, compared with the use of un-modified talc particles due to enhanced bonding to the matrix, larger aspect ratio, and fiber alignment for GFs. Mechanical properties and LCTE values of composites with combined talc and GF fillers varied with talc and GF ratio at a given total filler loading level. The use of a larger portion of GFs in the mix can lead to better composite performance, while the use of talc can help lower the composite costs and increase its recyclability. The use of 30 wt % combined filler seems necessary to control LCTE values of filled HDPE in the data value range generally reported for commercial wood plastic composites. Tensile modulus for talc-filled composite can be predicted with rule of mixture, while a PPA-based model can be used to predict the modulus and strength of GF-filled composites.

  2. Auditory mismatch negativity in schizophrenia: topographic evaluation with a high-density recording montage.

    Science.gov (United States)

    Hirayasu, Y; Potts, G F; O'Donnell, B F; Kwon, J S; Arakaki, H; Akdag, S J; Levitt, J J; Shenton, M E; McCarley, R W

    1998-09-01

    The mismatch negativity, a negative component in the auditory event-related potential, is thought to index automatic processes involved in sensory or echoic memory. The authors' goal in this study was to examine the topography of auditory mismatch negativity in schizophrenia with a high-density, 64-channel recording montage. Mismatch negativity topography was evaluated in 23 right-handed male patients with schizophrenia who were receiving medication and in 23 nonschizophrenic comparison subjects who were matched in age, handedness, and parental socioeconomic status. The Positive and Negative Syndrome Scale was used to measure psychiatric symptoms. Mismatch negativity amplitude was reduced in the patients with schizophrenia. They showed a greater left-less-than-right asymmetry than comparison subjects at homotopic electrode pairs near the parietotemporal junction. There were correlations between mismatch negativity amplitude and hallucinations at left frontal electrodes and between mismatch negativity amplitude and passive-apathetic social withdrawal at left and right frontal electrodes. Mismatch negativity was reduced in schizophrenia, especially in the left hemisphere. This finding is consistent with abnormalities of primary or adjacent auditory cortex involved in auditory sensory or echoic memory.

  3. A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

    Science.gov (United States)

    Duivenvoorden, Raphaël; Tang, Jun; Cormode, David P.; Mieszawska, Aneta J.; Izquierdo-Garcia, David; Ozcan, Canturk; Otten, Maarten J.; Zaidi, Neeha; Lobatto, Mark E.; van Rijs, Sarian M.; Priem, Bram; Kuan, Emma L.; Martel, Catherine; Hewing, Bernd; Sager, Hendrik; Nahrendorf, Matthias; Randolph, Gwendalyn J.; Stroes, Erik S. G.; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J. M.

    2014-01-01

    Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited with oral statin therapy due to low systemic bioavailability. Here we present an injectable reconstituted high-density lipoprotein (rHDL) nanoparticle carrier vehicle that delivers statins to atherosclerotic plaques. We demonstrate the anti-inflammatory effect of statin-rHDL in vitro and show that this effect is mediated through the inhibition of the mevalonate pathway. We also apply statin-rHDL nanoparticles in vivo in an apolipoprotein E-knockout mouse model of atherosclerosis and show that they accumulate in atherosclerotic lesions in which they directly affect plaque macrophages. Finally, we demonstrate that a 3-month low-dose statin-rHDL treatment regimen inhibits plaque inflammation progression, while a 1-week high-dose regimen markedly decreases inflammation in advanced atherosclerotic plaques. Statin-rHDL represents a novel potent atherosclerosis nanotherapy that directly affects plaque inflammation.

  4. Study of high density polyethylene under UV irradiation or mechanical stress by fluorescence spectroscopy

    International Nuclear Information System (INIS)

    Douminge, L.

    2010-05-01

    Due to their diversity and their wide range of applications, polymers have emerged in our environment. For technical applications, these materials can be exposed to aggressive environment leading to an alteration of their properties. The effects of this degradation are linked to the concept of life duration, corresponding to the time required for a property to reach a threshold below which the material becomes unusable. Monitoring the ageing of polymer materials constitute a major challenge. Fluorescence spectroscopy is a technique able to provide accurate information concerning this issue. In this study, emphasis was placed on the use of fluorescence spectroscopy to study the phenomena involved in either the UV radiation or mechanical stresses of a polymer. In the case of high density polyethylene, the lack of intrinsic fluorescent signal leads to the use of a dye. This dye gives a fluorescent response depending on its microenvironment. All modifications in the macromolecular chain generate a shift of the fluorescent peak. This work can be dissociated in two major parts, on one hand the influence of UV aging on the fluorescent response and in another hand the influence of mechanical stresses. In the first part, complementary analyses like FTIR or DSC are used to correlate fluorescent results with known photo degradation mechanisms. The results show the great sensibility of the technique to the microstructural rearrangement in the polymer. In the second part, the dependence between the stress and the fluorescence emission gives opportunity to evaluate internal stresses in the material during cyclic solicitations. (author)

  5. Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function

    Directory of Open Access Journals (Sweden)

    Jesús Osada

    2013-04-01

    Full Text Available High-density lipoprotein (HDL levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they acquire this phospholipid, and the important role that SM plays in regulating their fluidity and cholesterol efflux from different cells. In addition, plasma enzymes involved in HDL metabolism such as lecithin–cholesterol acyltransferase or phospholipid transfer protein are inhibited by HDL SM content. Likewise, HDL SM levels are influenced by dietary maneuvers (source of protein or fat, drugs (statins or diuretics and modified in diseases such as diabetes, renal failure or Niemann–Pick disease. Furthermore, increased levels of HDL SM have been shown to be an inverse risk factor for coronary heart disease. The complexity of SM species, described using new lipidomic methodologies, and their distribution in different HDL particles under many experimental conditions are promising avenues for further research in the future.

  6. Threshold-voltage modulated phase change heterojunction for application of high density memory

    International Nuclear Information System (INIS)

    Yan, Baihan; Tong, Hao; Qian, Hang; Miao, Xiangshui

    2015-01-01

    Phase change random access memory is one of the most important candidates for the next generation non-volatile memory technology. However, the ability to reduce its memory size is compromised by the fundamental limitations inherent in the CMOS technology. While 0T1R configuration without any additional access transistor shows great advantages in improving the storage density, the leakage current and small operation window limit its application in large-scale arrays. In this work, phase change heterojunction based on GeTe and n-Si is fabricated to address those problems. The relationship between threshold voltage and doping concentration is investigated, and energy band diagrams and X-ray photoelectron spectroscopy measurements are provided to explain the results. The threshold voltage is modulated to provide a large operational window based on this relationship. The switching performance of the heterojunction is also tested, showing a good reverse characteristic, which could effectively decrease the leakage current. Furthermore, a reliable read-write-erase function is achieved during the tests. Phase change heterojunction is proposed for high-density memory, showing some notable advantages, such as modulated threshold voltage, large operational window, and low leakage current

  7. Threshold-voltage modulated phase change heterojunction for application of high density memory

    Science.gov (United States)

    Yan, Baihan; Tong, Hao; Qian, Hang; Miao, Xiangshui

    2015-09-01

    Phase change random access memory is one of the most important candidates for the next generation non-volatile memory technology. However, the ability to reduce its memory size is compromised by the fundamental limitations inherent in the CMOS technology. While 0T1R configuration without any additional access transistor shows great advantages in improving the storage density, the leakage current and small operation window limit its application in large-scale arrays. In this work, phase change heterojunction based on GeTe and n-Si is fabricated to address those problems. The relationship between threshold voltage and doping concentration is investigated, and energy band diagrams and X-ray photoelectron spectroscopy measurements are provided to explain the results. The threshold voltage is modulated to provide a large operational window based on this relationship. The switching performance of the heterojunction is also tested, showing a good reverse characteristic, which could effectively decrease the leakage current. Furthermore, a reliable read-write-erase function is achieved during the tests. Phase change heterojunction is proposed for high-density memory, showing some notable advantages, such as modulated threshold voltage, large operational window, and low leakage current.

  8. Analytical thermal modelling of multilayered active embedded chips into high density electronic board

    Directory of Open Access Journals (Sweden)

    Monier-Vinard Eric

    2013-01-01

    Full Text Available The recent Printed Wiring Board embedding technology is an attractive packaging alternative that allows a very high degree of miniaturization by stacking multiple layers of embedded chips. This disruptive technology will further increase the thermal management challenges by concentrating heat dissipation at the heart of the organic substrate structure. In order to allow the electronic designer to early analyze the limits of the power dissipation, depending on the embedded chip location inside the board, as well as the thermal interactions with other buried chips or surface mounted electronic components, an analytical thermal modelling approach was established. The presented work describes the comparison of the analytical model results with the numerical models of various embedded chips configurations. The thermal behaviour predictions of the analytical model, found to be within ±10% of relative error, demonstrate its relevance for modelling high density electronic board. Besides the approach promotes a practical solution to study the potential gain to conduct a part of heat flow from the components towards a set of localized cooled board pads.

  9. Application of Inkjet Printing in High-Density Pixelated RGB Quantum Dot-Hybrid LEDs

    KAUST Repository

    Haverinen, Hanna

    2012-05-23

    Recently, an intriguing solution to obtain better color purity has been to introduce inorganic emissive quantum dots (QDs) into an otherwise OLED structure. The emphasis of this chapter is to present a simple discussion of the first attempts to fabricate high-density, pixelated (quarter video graphics array (QVGA) format), monochromatic and RGB quantum dots light-emitting diodes (QDLEDs), where inkjet printing is used to deposit the light-emitting layer of QDs. It shows some of the factors that have to be considered in order to achieve the desired accuracy and printing quality. The successful operation of the RGB printed devices indicates the potential of the inkjet printing approach in the fabrication of full-color QDLEDs for display application. However, further optimization of print quality is still needed in order to eliminate the formation of pinholes, thus maximizing energy transfer from organic layers to the QDs and in turn increasing the performance of the devices. Controlled Vocabulary Terms: ink jet printing; LED displays; LED lamps; organic light emitting diodes; quantum dots

  10. Very high-density planets: a possible remnant of gas giants.

    Science.gov (United States)

    Mocquet, A; Grasset, O; Sotin, C

    2014-04-28

    Data extracted from the Extrasolar Planets Encyclopaedia (see http://exoplanet.eu) show the existence of planets that are more massive than iron cores that would have the same size. After meticulous verification of the data, we conclude that the mass of the smallest of these planets is actually not known. However, the three largest planets, Kepler-52b, Kepler-52c and Kepler-57b, which are between 30 and 100 times the mass of the Earth, have indeed density larger than an iron planet of the same size. This observation triggers this study that investigates under which conditions these planets could represent the naked cores of gas giants that would have lost their atmospheres during their migration towards the star. This study shows that for moderate viscosity values (10(25) Pa s or lower), large values of escape rate and associated unloading stress rate during the atmospheric loss process lead to the explosion of extremely massive planets. However, for moderate escape rate, the bulk viscosity and finite-strain incompressibility of the cores of giant planets can be large enough to retain a very high density during geological time scales. This would make those a new kind of planet, which would help in understanding the interior structure of the gas giants. However, this new family of exoplanets adds some degeneracy for characterizing terrestrial exoplanets.

  11. Fundamental properties of high-quality carbon nanofoam: from low to high density

    Directory of Open Access Journals (Sweden)

    Natalie Frese

    2016-12-01

    Full Text Available Highly uniform samples of carbon nanofoam from hydrothermal sucrose carbonization were studied by helium ion microscopy (HIM, X-ray photoelectron spectroscopy (XPS, and Raman spectroscopy. Foams with different densities were produced by changing the process temperature in the autoclave reactor. This work illustrates how the geometrical structure, electron core levels, and the vibrational signatures change when the density of the foams is varied. We find that the low-density foams have very uniform structure consisting of micropearls with ≈2–3 μm average diameter. Higher density foams contain larger-sized micropearls (≈6–9 μm diameter which often coalesced to form nonspherical μm-sized units. Both, low- and high-density foams are comprised of predominantly sp2-type carbon. The higher density foams, however, show an advanced graphitization degree and a stronger sp3-type electronic contribution, related to the inclusion of sp3 connections in their surface network.

  12. Irish study of high-density Schizophrenia families: Field methods and power to detect linkage

    Energy Technology Data Exchange (ETDEWEB)

    Kendler, K.S.; Straub, R.E.; MacLean, C.J. [Virginia Commonwealth Univ., Richmond, VA (United States)] [and others

    1996-04-09

    Large samples of multiplex pedigrees will probably be needed to detect susceptibility loci for schizophrenia by linkage analysis. Standardized ascertainment of such pedigrees from culturally and ethnically homogeneous populations may improve the probability of detection and replication of linkage. The Irish Study of High-Density Schizophrenia Families (ISHDSF) was formed from standardized ascertainment of multiplex schizophrenia families in 39 psychiatric facilities covering over 90% of the population in Ireland and Northern Ireland. We here describe a phenotypic sample and a subset thereof, the linkage sample. Individuals were included in the phenotypic sample if adequate diagnostic information, based on personal interview and/or hospital record, was available. Only individuals with available DNA were included in the linkage sample. Inclusion of a pedigree into the phenotypic sample required at least two first, second, or third degree relatives with non-affective psychosis (NAP), one of whom had schizophrenia (S) or poor-outcome schizoaffective disorder (PO-SAD). Entry into the linkage sample required DNA samples on at least two individuals with NAP, of whom at least one had S or PO-SAD. Affection was defined by narrow, intermediate, and broad criteria. 75 refs., 6 tabs.

  13. Achieving precision in high density batch mode micro-electro-discharge machining

    International Nuclear Information System (INIS)

    Richardson, Mark T; Gianchandani, Yogesh B

    2008-01-01

    This paper reports a parametric study of batch mode micro-electro-discharge machining (µEDM) of high density features in stainless steel. Lithographically fabricated copper tools with single cross, parallel line and 8 × 8 circle/square array features of 5–100 µm width and 5–75 µm spacing were used to quantify trends in machining tolerance and the impact of debris accumulation. As the tool feature density is increased, debris accumulation effects begin to dominate, eventually degrading both tool and workpiece. Two independent techniques for mitigating this debris buildup are separately investigated. The first is a passivation coating which suppresses spurious discharges triggered from the sidewalls of the machining tool. By this method, the mean tool wear rate decreases from a typical of about 34% to 1.7% and machining non-uniformity reduces from 4.9 µm to 1.1 µm across the workpiece. The second technique involves a two-step machining process that enhances the hydrodynamic removal of machining debris compared to standard methods. This improves surface and edge finish, machining time and tool wear

  14. Multi-resolution analysis of high density spatial and temporal cloud inhomogeneity fields from HOPE campaign

    Science.gov (United States)

    Lakshmi Madhavan, Bomidi; Deneke, Hartwig; Macke, Andreas

    2015-04-01

    Clouds are the most complex structures in both spatial and temporal scales of the Earth's atmosphere that effect the downward surface reaching fluxes and thus contribute to large uncertainty in the global radiation budget. Within the framework of High Definition Clouds and Precipitation for advancing Climate Prediction (HD(CP)2) Observational Prototype Experiment (HOPE), a high density network of 99 pyranometer stations was set up around Jülich, Germany (~ 10 × 12 km2 area) during April to July 2013 to capture the small-scale variability in cloud induced radiation fields at the surface. In this study, we perform multi-resolution analysis of the downward solar irradiance variability at the surface from the pyranometer network to investigate the dependence of temporal and spatial averaging scales on the variance and spatial correlation for different cloud regimes. Preliminary results indicate that correlation is strongly scale-dependent where as the variance is dependent on the length of averaging period. Implications of our findings will be useful for quantifying the effect of spatial collocation while validating the satellite inferred solar irradiance estimates, and also to explore the link between cloud structure and radiation. We will present the details of our analysis and results.

  15. High Density Infrared (HDI) Transient Liquid Coatings for Improved Wear and Corrosion Resistance

    Energy Technology Data Exchange (ETDEWEB)

    Ronald W. Smith

    2007-07-05

    This report documents a collaborative effort between Oak Ridge National Laboratory (ORNL), Materials Resources International and an industry team of participants to develop, evaluate and understand how high density infrared heating technology could be used to improve infiltrated carbide wear coatings and/or to densify sprayed coatings. The research included HDI fusion evaluations of infiltrated carbide suspensions such (BrazeCoat® S), composite suspensions with tool steel powders, thermally sprayed Ni-Cr- B-Si (self fluxing alloy) and nickel powder layers. The applied work developed practical HDI / transient liquid coating (TLC) procedures on test plates that demonstrated the ability to fuse carbide coatings for industrial applications such as agricultural blades, construction and mining vehicles. Fundamental studies helped create process models that led to improved process understanding and control. The coating of agricultural blades was demonstrated and showed the HDI process to have the ability to fuse industrial scale components. Sliding and brasive wear tests showed that high degree of wear resistance could be achieved with the addition of tool steel powders to carbide particulate composites.

  16. Curaua fiber reinforced high-density polyethylene composites: effect of impact modifier and fiber loading

    Directory of Open Access Journals (Sweden)

    Jaqueline Albano de Morais

    Full Text Available Abstract Short fibers are used in thermoplastic composites to increase their tensile and flexural resistance; however, it often decreases impact resistance. Composites with short vegetal fibers are not an exception to this behavior. The purpose of this work is to produce a vegetal fiber reinforced composite with improved tensile and impact resistance in relation to the polymer matrix. We used poly(ethylene-co-vinyl acetate, EVA, to recover the impact resistance of high density polyethylene, HDPE, reinforced with Curauá fibers, CF. Blends and composites were processed in a corotating twin screw extruder. The pure polymers, blends and composites were characterized by differential scanning calorimetry, thermogravimetry, infrared spectroscopy, scanning electron microscopy, tensile mechanical properties and Izod impact resistance. EVA used as impact modifier in the HDPE matrix exhibited a co-continuous phase and in the composites the fibers were homogeneously dispersed. The best combination of mechanical properties, tensile, flexural and impact, were obtained for the formulations of composites with 20 wt. % of CF and 20 to 40 wt. % of EVA. The composite prepared with 20 wt. % EVA and containing 30 wt. % of CF showed impact resistance comparable to pure HDPE and improved tensile and flexural mechanical properties.

  17. Fueling requirements of super-high-density plasmas towards innovative ignition regime

    International Nuclear Information System (INIS)

    Sakamoto, Ryuichi; Yamada, Hiroshi

    2014-01-01

    Highlights: • Self-burning scenario with internal diffusion barrier is investigated. • Peaked density profiles allow to sustain self-burning plasma at lower temperature. • Core fueling beyond internal diffusion barrier is essential to sustain peaked density. • Acceptable pellet size becomes small to prevent fusion out perturbation. • Very high velocity pellet injection beyond 10 km/s is inevitable for this scenario. - Abstract: Super-high-density plasma with an internal diffusion barrier which is observed in the Large Helical Device has been extrapolated to a fusion reactor grade plasma to explore an innovative ignition regime and to clarify essential requirements for pellet fueling. The peaked density profiles due to the internal diffusion barrier formation allow reduction in the required minimum temperature to sustain a self-burning plasma down to 10 keV. Direct core fueling beyond the internal diffusion barrier is essential to sustain the peaked density profile. Furthermore, the acceptable pellet size becomes small in terms of fusion output perturbation because the effective volume of the burning plasma becomes small with the peaked density profile. In order to sustain a self-burning plasma with an internal diffusion barrier, therefore, extremely high velocity pellet injection beyond 10 km/s is inevitable unless another solution to the core fueling is found

  18. Transcription profiling of the early gravitropic response in Arabidopsis using high-density oligonucleotide probe microarrays

    Science.gov (United States)

    Moseyko, Nick; Zhu, Tong; Chang, Hur-Song; Wang, Xun; Feldman, Lewis J.

    2002-01-01

    Studies of plant tropisms, the directed growth toward or away from external stimuli such as light and gravity, began more than a century ago. Yet biochemical, physiological, and especially molecular mechanisms of plant tropic responses remain for the most part unclear. We examined expression of 8,300 genes during early stages of the gravitropic response using high-density oligonucleotide probe microarrays. Approximately 1.7% of the genes represented on the array exhibited significant expression changes within the first 30 min of gravity stimulation. Among gravity-induced genes were a number of genes previously implicated to be involved in gravitropism. However, a much larger number of the identified genes have not been previously associated with gravitropism. Because reorientation of plants may also expose plants to mechanical perturbations, we also compared the effects of a gentle mechanical perturbation on mRNA levels during the gravity response. It was found that approximately 39% of apparently gravity-regulated genes were also regulated by the mechanical perturbation caused by plant reorientation. Our study revealed the induction of complex gene expression patterns as a consequence of gravitropic reorientation and points to an interplay between the gravitropic and mechanical responses and to the extreme sensitivity of plants to even very gentle mechanical perturbations.

  19. Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications.

    Science.gov (United States)

    Cho, Kyung-Hyun

    2009-07-31

    High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and structural changes of HDL have been recognized as factors pivotal to the evaluation of HDL-quality. In this review, I have elected to focus on the functional and structural correlations of HDL and the roles of HDL-associated apolipoproteins and enzymes. Recent clinical applications of HDL have also been reviewed, particularly the therapeutic targeting of HDL metabolism and reconstituted HDL; these techniques represent promising emerging strategies for the treatment of cardiovascular disease, for drug or gene therapy.

  20. High density experiments with gas puffing and ECRH in T-10

    International Nuclear Information System (INIS)

    Esipchuk, Yu V; Kirneva, N A; Borschegovskij, A A; Chistyakov, V V; Denisov, V Ph; Dremin, M M; Gorbunov, E P; Grashin, S A; Kalupin, D V; Khimchenko, L N; Khramenkov, A V; Kirnev, G S; Krilov, S V; Krupin, V A; Myalton, T B; Pavlov, Yu D; Piterskij, V V; Ploskirev, G N; Poznyak, V I; Roy, I N; Shelukhin, D A; Skosyrev, Yu V; Trukhin, V M; Trukhina, E V; Vershkov, V A; Veschev, E A; Volkov, V V; Zhuravlev, V A

    2003-01-01

    High density experiments were carried out in T-10 with gas puffing and electron cyclotron resonance heating (with absorbed power value up to 1.4 MW) with oblique and perpendicular power launch. Densities exceeding the Greenwald limit (n Gw ) by up to a factor of 1.8 were achieved in a regime with a high value of the edge safety factor at the current flat-top, q(a)≅8.2. The decrease of q(a) to a value of 3 led to the reduction of the ratio ( n-bar e ) lim /n Gw to 1. Confinement degradation with density increase was not significant up to the density limit. However, the typical T-10 linear increase of energy confinement time with density saturates at n-bar e ≥0.6n Gw . This saturation is the result of the development of an additional transport in the electron heat channel. However, the saturated τ E values exceeded the ITER L-mode scaling predictions by up to a factor of 1.2 and were close to the value predicted by the ITER H-mode scaling. Effect of the strong gas puffing on the plasma confinement and experiments with neon seeding are also discussed in this paper

  1. Sorption Isotherm of Southern Yellow Pine—High Density Polyethylene Composites

    Directory of Open Access Journals (Sweden)

    Feihong Liu

    2015-01-01

    Full Text Available Temperature and relative humidity (RH are two major external factors, which affect equilibrium moisture content (EMC of wood-plastic composites (WPCs. In this study, the effect of different durability treatments on sorption and desorption isotherms of southern yellow pine (SYP-high density polyethylene (HDPE composites was investigated. All samples were equilibriumed at 20 °C and various RHs including 16%, 33%, 45%, 66%, 75%, 85%, 93%, and100%. EMCs obtained from desorption and absorption for different WPC samples were compared with Nelson’s sorption isotherm model predictions using the same temperature and humidity conditions. The results indicated that the amount of moisture absorbed increased with the increases in RH at 20 °C. All samples showed sorption hysteresis at a fixed RH. Small difference between EMC data of WPC samples containing different amount of ultraviolet (UV stabilizers were observed. Similar results were observed among the samples containing different amount of zinc borate (ZB. The experimental data of EMCs at various RHs fit to the Nelson’s sorption isotherm model well. The Nelson’s model can be used to predicate EMCs of WPCs under different RH environmental conditions.

  2. High Density Polyethylene Composites Reinforced with Hybrid Inorganic Fillers: Morphology, Mechanical and Thermal Expansion Performance

    Directory of Open Access Journals (Sweden)

    Birm-June Kim

    2013-09-01

    Full Text Available The effect of individual and combined talc and glass fibers (GFs on mechanical and thermal expansion performance of the filled high density polyethylene (HDPE composites was studied. Several published models were adapted to fit the measured tensile modulus and strength of various composite systems. It was shown that the use of silane-modified GFs had a much larger effect in improving mechanical properties and in reducing linear coefficient of thermal expansion (LCTE values of filled composites, compared with the use of un-modified talc particles due to enhanced bonding to the matrix, larger aspect ratio, and fiber alignment for GFs. Mechanical properties and LCTE values of composites with combined talc and GF fillers varied with talc and GF ratio at a given total filler loading level. The use of a larger portion of GFs in the mix can lead to better composite performance, while the use of talc can help lower the composite costs and increase its recyclability. The use of 30 wt % combined filler seems necessary to control LCTE values of filled HDPE in the data value range generally reported for commercial wood plastic composites. Tensile modulus for talc-filled composite can be predicted with rule of mixture, while a PPA-based model can be used to predict the modulus and strength of GF-filled composites.

  3. A New CDS Structure for High Density FPA with Low Power

    Directory of Open Access Journals (Sweden)

    Xiao Wang

    2015-01-01

    Full Text Available Being an essential part of infrared readout integrated circuit, correlated double sampling (CDS circuits play important roles in both depressing reset noise and conditioning integration signals. To adapt applications for focal planes of large format and high density, a new structure of CDS circuit occupying small layout area is proposed, whose power dissipation has been optimized by using MOSFETs in operation of subthreshold region, which leads to 720 nW. Then the noise calculation model is established, based on which the noise analysis has been carried out by the approaches of transfer function and numerical simulations using SIMULINK and Verilog-A. The results are in good agreement, demonstrating the validity of the present noise calculation model. Thermal noise plays a dominant role in the long wave situation while 1/f noise is the majority in the medium wave situation. The total noise of long wave is smaller than medium wave, both of which increase with the integration capacitor and integration time increasing.

  4. Modeling benzene permeation through drinking water high density polyethylene (HDPE) pipes.

    Science.gov (United States)

    Mao, Feng; Ong, Say Kee; Gaunt, James A

    2015-09-01

    Organic compounds such as benzene, toluene, ethyl benzene and o-, m-, and p-xylene from contaminated soil and groundwater may permeate through thermoplastic pipes which are used for the conveyance of drinking water in water distribution systems. In this study, permeation parameters of benzene in 25 mm (1 inch) standard inside dimension ratio (SIDR) 9 high density polyethylene (HDPE) pipes were estimated by fitting the measured data to a permeation model based on a combination of equilibrium partitioning and Fick's diffusion. For bulk concentrations between 6.0 and 67.5 mg/L in soil pore water, the concentration-dependent diffusion coefficients of benzene were found to range from 2.0×10(-9) to 2.8×10(-9) cm2/s while the solubility coefficient was determined to be 23.7. The simulated permeation curves of benzene for SIDR 9 and SIDR 7 series of HDPE pipes indicated that small diameter pipes were more vulnerable to permeation of benzene than large diameter pipes, and the breakthrough of benzene into the HDPE pipe was retarded and the corresponding permeation flux decreased with an increase of the pipe thickness. HDPE pipes exposed to an instantaneous plume exhibited distinguishable permeation characteristics from those exposed to a continuous source with a constant input. The properties of aquifer such as dispersion coefficients (DL) also influenced the permeation behavior of benzene through HDPE pipes.

  5. The impact of high-density barium use in double contrast radiographic methods for gastric cancer screening in Niigata, Japan.

    Science.gov (United States)

    Wakai, Shizuko; Tanabe, Naohito; Suzuki, Hiroshi

    2005-04-01

    Use of high-density barium (= or > 180 w/v%) has been widely spread in community-based mass screening for gastric cancer in Japan. However, the impact on outcomes of the screening has not been fully evaluated. Then, we investigated the advantage of high-density barium use by comparing the outcomes between a period with high-density barium and that with low-density barium (barium decreases the positive finding rate in initial mass screening x-ray examinations by 12% (odds ratio, 0.88; 95% confidence interval, 0.86 - 0.90) and increase the gastric cancer detection rate by diagnostic examination by 15% (odds ratio, 1.15; 95% confidence interval, 1.01-1.31). We conclude that introduction of high-density barium has improved the efficiency of mass screening for gastric cancer by decreasing unnecessary diagnostic examinations and reducing the total personal and public health costs. Thus, nationwide use of high-density barium is recommended for mass gastric cancer screening in Japan.

  6. Application of High-Density Electropulsing to Improve the Performance of Metallic Materials: Mechanisms, Microstructure and Properties

    Directory of Open Access Journals (Sweden)

    Yinying Sheng

    2018-01-01

    Full Text Available The technology of high-density electropulsing has been applied to increase the performance of metallic materials since the 1990s and has shown significant advantages over traditional heat treatment in many aspects. However, the microstructure changes in electropulsing treatment (EPT metals and alloys have not been fully explored, and the effects vary significantly on different material. When high-density electrical pulses are applied to metals and alloys, the input of electric energy and thermal energy generally leads to structural rearrangements, such as dynamic recrystallization, dislocation movements and grain refinement. The enhanced mechanical properties of the metals and alloys after high-density electropulsing treatment are reflected by the significant improvement of elongation. As a result, this technology holds great promise in improving the deformation limit and repairing cracks and defects in the plastic processing of metals. This review summarizes the effect of high-density electropulsing treatment on microstructural properties and, thus, the enhancement in mechanical strength, hardness and corrosion performance of metallic materials. It is noteworthy that the change of some properties can be related to the structure state before EPT (quenched, annealed, deformed or others. The mechanisms for the microstructural evolution, grain refinement and formation of oriented microstructures of different metals and alloys are presented. Future research trends of high-density electrical pulse technology for specific metals and alloys are highlighted.

  7. Application of High-Density Electropulsing to Improve the Performance of Metallic Materials: Mechanisms, Microstructure and Properties.

    Science.gov (United States)

    Sheng, Yinying; Hua, Youlu; Wang, Xiaojian; Zhao, Xueyang; Chen, Lianxi; Zhou, Hanyu; Wang, James; Berndt, Christopher C; Li, Wei

    2018-01-24

    The technology of high-density electropulsing has been applied to increase the performance of metallic materials since the 1990s and has shown significant advantages over traditional heat treatment in many aspects. However, the microstructure changes in electropulsing treatment (EPT) metals and alloys have not been fully explored, and the effects vary significantly on different material. When high-density electrical pulses are applied to metals and alloys, the input of electric energy and thermal energy generally leads to structural rearrangements, such as dynamic recrystallization, dislocation movements and grain refinement. The enhanced mechanical properties of the metals and alloys after high-density electropulsing treatment are reflected by the significant improvement of elongation. As a result, this technology holds great promise in improving the deformation limit and repairing cracks and defects in the plastic processing of metals. This review summarizes the effect of high-density electropulsing treatment on microstructural properties and, thus, the enhancement in mechanical strength, hardness and corrosion performance of metallic materials. It is noteworthy that the change of some properties can be related to the structure state before EPT (quenched, annealed, deformed or others). The mechanisms for the microstructural evolution, grain refinement and formation of oriented microstructures of different metals and alloys are presented. Future research trends of high-density electrical pulse technology for specific metals and alloys are highlighted.

  8. Application of High-Density Electropulsing to Improve the Performance of Metallic Materials: Mechanisms, Microstructure and Properties

    Science.gov (United States)

    Sheng, Yinying; Hua, Youlu; Zhao, Xueyang; Chen, Lianxi; Zhou, Hanyu; Wang, James; Berndt, Christopher C.; Li, Wei

    2018-01-01

    The technology of high-density electropulsing has been applied to increase the performance of metallic materials since the 1990s and has shown significant advantages over traditional heat treatment in many aspects. However, the microstructure changes in electropulsing treatment (EPT) metals and alloys have not been fully explored, and the effects vary significantly on different material. When high-density electrical pulses are applied to metals and alloys, the input of electric energy and thermal energy generally leads to structural rearrangements, such as dynamic recrystallization, dislocation movements and grain refinement. The enhanced mechanical properties of the metals and alloys after high-density electropulsing treatment are reflected by the significant improvement of elongation. As a result, this technology holds great promise in improving the deformation limit and repairing cracks and defects in the plastic processing of metals. This review summarizes the effect of high-density electropulsing treatment on microstructural properties and, thus, the enhancement in mechanical strength, hardness and corrosion performance of metallic materials. It is noteworthy that the change of some properties can be related to the structure state before EPT (quenched, annealed, deformed or others). The mechanisms for the microstructural evolution, grain refinement and formation of oriented microstructures of different metals and alloys are presented. Future research trends of high-density electrical pulse technology for specific metals and alloys are highlighted. PMID:29364844

  9. Helicon wave propagation and plasma equilibrium in high-density hydrogen plasma in converging magnetic fields

    Science.gov (United States)

    Caneses Marin, Juan Francisco

    In this thesis, we investigate wave propagation and plasma equilibrium in MAGPIE, a helicon based linear plasma device constructed at the Australian National University, to study plasma-material interactions under divertor-relevant plasma conditions. We show that MAGPIE is capable of producing low temperature (1–8 eV) high density hydrogen plasma (2–3x10. 19 m-3) with 20 kW of RF power when the confining magnetic field is converging. The original research herein described comprises: (1) Characterization of hydrogen plasma in MAGPIE, (2) Analysis of the RF compensation of double Langmuir probes, (3) Excitation, propagation and damping of helicon waves in uniform and non-uniform magnetic fields and (4) Steady-state force balance and equilibrium profiles in MAGPIE. We develop an analytical model of the physics of floating probes to describe and quantify the RF compensation of the DLP technique. Experimental validation for the model is provided. We show that (1) whenever finite sheath effects are important, overestimation of the ion density is proportional to the level of RF rectification and suggest that (2) electron temperature measurements are weakly affected. We develop a uniform plasma full wave code to describe wave propagation in MAGPIE. We show that under typical MAGPIE operating conditions, the helical antenna is not optimized to couple waves in the plasma; instead, the antenna’s azimuthal current rings excites helicon waves which propagate approximately along the whistler wave ray direction, constructively interfere on-axis and lead to the formation of an axial interference pattern. We show that helicon wave attenuation can be explained entirely through electron-ion and electron-neutral collisions. Results from a two-dimensional full wave code reveal that RF power deposition is axially non-uniform with both edge and on-axis components associated with the TG and helicon wave respectively. Finally, force balance analysis in MAGPIE using a two-fluid

  10. Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma

    Directory of Open Access Journals (Sweden)

    Kuai R

    2017-09-01

    Full Text Available Rui Kuai,1,2,* Chitra Subramanian,3,* Peter T White,3,* Barbara N Timmermann,4 James J Moon,1,2,5 Mark S Cohen,3,6 Anna Schwendeman1,2 1Department of Pharmaceutical Sciences, College of Pharmacy, 2Biointerfaces Institute, University of Michigan, 3Department of Surgery, University of Michigan, Ann Arbor, MI, 4Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, 5Department of Biomedical Engineering, 6Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA *These authors contributed equally to this work Abstract: Adrenocortical carcinoma (ACC is a rare endocrine malignancy and has a 5-year survival rate of <35%. ACC cells require cholesterol for steroid hormone production, and this requirement is met via expression on the cell surface of a high level of SRB1, responsible for the uptake of high-density lipoproteins (HDLs, which carry and transport cholesterol in vivo. Here, we describe how this natural lipid carrier function of SRB1 can be utilized to improve the tumor-targeted delivery of a novel natural product derivative – withalongolide A 4,19,27-triacetate (WGA-TA – which has shown potent antitumor efficacy, but poor aqueous solubility. Our strategy was to use synthetic HDL (sHDL nanodisks, which are effective in tumor-targeted delivery due to their smallness, long circulation half-life, documented safety, and ability to bind to SRB1. In this study, we prepared sHDL nanodisks using an optimized phospholipid composition combined with ApoA1 mimetic peptide (22A, which has previously been tested in clinical trials, to load WGA-TA. Following optimization, WGA-TA nanodisks showed drug encapsulation efficiency of 78%, a narrow particle size distribution (9.81±0.41 nm, discoid shape, and sustained drug release in phosphate buffered saline. WGA-TA-sHDL nanodisks exhibited higher cytotoxicity in the ACC cell line H295R half maximal inhibitory concentration ([IC50] 0.26±0.045 µM than free WGA-TA (IC50 0.492±0

  11. Genomewide linkage of Obstructive Sleep Apnea and High Density Lipoprotein Cholesterol in a Filipino Family

    Science.gov (United States)

    Relf, Bronwyn L; Larkin, Emma K; de Torres, Carina; Baur, Louise A; Christodoulou, John; Waters, Karen A

    2015-01-01

    Summary Increasing evidence supports an association between obstructive sleep apnoea and metabolic syndrome in both children and adults suggesting a genetic component. However, the genetic relationship between the diseases remains unclear. We performed a bivariate linkage scan on a single Filipino family with a high prevalence of obstructive sleep apnoea and metabolic syndrome to explore the genetic pathways underlying these diseases. A large rural family (N=50, 50% adults) underwent a 10cM genome-wide scan. Fasting blood was used to measure insulin, triglycerides, total cholesterol and HDL cholesterol. Attended overnight polysomnography was used to quantify the respiratory disturbance index (RDI), a measure of sleep apnea. BMI z-scores and insulin resistance scores were calculated. Bivariate multipoint linkage analyses were performed on RDI and metabolic syndrome components. Obstructive sleep apnea prevalence was 46% (n=23; 9 adults, 14 children) in our participants. Metabolic syndrome phenotype was present in 40% of adults (n=10) and 48% of children (n=12). Linkage peaks with a LOD score > 3 were demonstrated on chromosome 19q13·4 (LOD=3·04) for the trait pair RDI and high density lipoprotein (HDL) cholesterol. Candidate genes identified in this region include the killer-like immunoglobulin receptor (KIR) genes. These genes are associated with modulating inflammatory responses in reaction to cellular stress and initiation of atherosclerotic plaque formation. We have identified a novel locus for genetic links between RDI and lipid factors associated with metabolic syndrome in a chromosomal region containing genes associated with inflammatory responses. PMID:20149069

  12. Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.

    Science.gov (United States)

    Yeap, Sherlyn; Kelly, Simon P; Reilly, Richard B; Thakore, Jogin H; Foxe, John J

    2009-11-01

    Etiological commonalities are apparent between bipolar disorder and schizophrenia. For example, it is becoming clear that both populations show similar electrophysiological deficits in the auditory domain. Recent studies have also shown robust visual sensory processing deficits in patients with schizophrenia using the event-related potential technique, but this has not been formally tested in those with bipolar disorder. Our goal here was to assess whether early visual sensory processing in patients with bipolar disorder, as indexed by decreased amplitude of the P1 component of the visual evoked potential (VEP), would show a similar deficit to that seen in those with schizophrenia. Since the P1 deficit has already been established as an endophenotype in schizophrenia, a finding of commonality between disorders would raise the possibility that it represents a measure of common genetic liability. We visually presented isolated-check stimuli to euthymic patients with a diagnosis of bipolar disorder and age-matched healthy controls within a simple go/no-go task and recorded VEPs using high-density (72-channel) electroencephalography. The P1 VEP amplitude was substantially reduced in patients with bipolar disorder, with an effect size of f = 0.56 (large according to Cohen's criteria). Our sample size was relatively small and as such, did not allow for an examination of potential relations between the physiologic measures and clinical measures. This reduction in P1 amplitude among patients with bipolar disorder represents a dysfunction in early visual processing that is highly similar to that found repeatedly in patients with schizophrenia and their healthy first-degree relatives. Since the P1 deficit has been related to susceptibility genes for schizophrenia, our results raise the possibility that the deficit may in fact be more broadly related to the development of psychosis and that it merits further investigation as a candidate endophenotype for bipolar disorder.

  13. Effect of expanded graphite on the phase change materials of high density polyethylene/wax blends

    Energy Technology Data Exchange (ETDEWEB)

    AlMaadeed, M.A., E-mail: m.alali@qu.edu.qa [Center for Advanced Materials, Qatar University, 2713 Doha (Qatar); Labidi, Sami [Center for Advanced Materials, Qatar University, 2713 Doha (Qatar); Krupa, Igor [QAPCO Polymer Chair, Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha (Qatar); Karkri, Mustapha [Université Paris-Est CERTES, 61 avenue du Général de Gaulle, 94010 Créteil (France)

    2015-01-20

    Highlights: • Expanded graphite (EG) and low melting point (42.3 °C) wax were added to HDPE to form phase change material. • EG was well dispersed in the composites and did not affect the melting or crystallization of the HDPE matrix. • EG increased the thermal stability of the composites by reducing chain mobility and inhibiting degradation. • The addition of a relatively small quantity of EG enhances the heat conduction in the composite. • HDPE/40% RT42 that contained up to 15% EG demonstrated excellent mechanical and thermal properties and can be used as PCM. - Abstract: Phase change materials fabricated from high density polyethylene (HDPE) blended with 40 or 50 wt% commercial wax (melting point of 43.08 °C) and up to 15 wt% expanded graphite (EG) were studied. Techniques including scanning electron microscope (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and an experimental device to measure diffusivity and conductivity (DICO) were used to determine the microstructural, mechanical and thermal properties of the composites. The composites possessed good mechanical properties. Additionally, no leaching was observed during material processing or characterization. Although the Young’s modulus increased with the addition of EG, no significant changes in tensile strength were detected. The maximum Young’s modulus achieved was 650 MPa for the HDPE/40% wax composite with 15 wt% EG. The EG was well dispersed within the composites and did not affect the melting or crystallization of the HDPE matrix. The incorporation of EG increased the thermal stability of the composites by reducing chain mobility and inhibiting degradation. The intensification of thermal conductivity occurred with increasing fractions of EG, which was attributed to the high thermal conductivity of graphite. The maximum quantity of heat stored by latent heat was found for the HDPE/40% wax composite with EG. The addition of a relatively small quantity

  14. Electron beam irradiation process applied to primary and secondary recycled high density polyethylene

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Jéssica R.; Moura, Eduardo de; Geraldo, Áurea B.C., E-mail: ageraldo@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    Plastic bags, packaging and furniture items are examples of plastic utilities always present in life. However, the end-of-life of plastics impacts the environment because of this ubiquity and also often their high degradation time. Recycling processes are important in this scenario because they offer many solutions to this problem. Basically, four ways are known for plastic recycling: primary recycling, which consists in re-extrusion of clean plastic scraps from a production plant; secondary recycling, that uses end-of-life products that generally are reduced in size by extrusion to obtain a more desirable shape for reprocessing (pellets and powder); tertiary recover which is related to thermo-chemical methods to produce fuels and petrochemical feedstock; and quaternary route, that is related to energy recovery and it is done in appropriate reactors. In this work, high density polyethylene (HDPE) was recovered to simulate empirically the primary and secondary recycling ways using materials which ranged from pristine to 20-fold re-extrused materials. The final 20-fold recycled thermoplastic was irradiated in an electron beam accelerator under a dose rate of 22.4 kGy/s and absorbed doses of 50 kGy and 100 kGy. The characterization of HDPE in distinct levels of recovering was performed by infrared spectroscopy (FTIR) and thermogravimetric degradation. In the HDPE recycling, degradation and crosslinking are consecutive processes; degradation is very noticeable in the 20-fold recycled product. Despite this, the 20-fold recycled product presents crosslinking after irradiation process and the post-irradiation product presents similarities in spectroscopic and thermal degradation characteristics of pristine, irradiated HDPE. These results are discussed. (author)

  15. Structures of discoidal high density lipoproteins: a combined computational-experimental approach.

    Science.gov (United States)

    Gu, Feifei; Jones, Martin K; Chen, Jianguo; Patterson, James C; Catte, Andrea; Jerome, W Gray; Li, Ling; Segrest, Jere P

    2010-02-12

    Conversion of discoidal phospholipid (PL)-rich high density lipoprotein (HDL) to spheroidal cholesteryl ester-rich HDL is a central step in reverse cholesterol transport. A detailed understanding of this process and the atheroprotective role of apolipoprotein A-I (apoA-I) requires knowledge of the structure and dynamics of these various particles. This study, combining computation with experimentation, illuminates structural features of apoA-I allowing it to incorporate varying amounts of PL. Molecular dynamics simulated annealing of PL-rich HDL models containing unesterified cholesterol results in double belt structures with the same general saddle-shaped conformation of both our previous molecular dynamics simulations at 310 K and the x-ray structure of lipid-free apoA-I. Conversion from a discoidal to a saddle-shaped particle involves loss of helicity and formation of loops in opposing antiparallel parts of the double belt. During surface expansion caused by the temperature-jump step, the curved palmitoyloleoylphosphatidylcholine bilayer surfaces approach planarity. Relaxation back into saddle-shaped structures after cool down and equilibration further supports the saddle-shaped particle model. Our kinetic analyses of reconstituted particles demonstrate that PL-rich particles exist in discrete sizes corresponding to local energetic minima. Agreement of experimental and computational determinations of particle size/shape and apoA-I helicity provide additional support for the saddle-shaped particle model. Truncation experiments combined with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability of PL-rich HDL particles. We propose that apoA-I incorporates increasing PL in the form of minimal surface bilayers through the incremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure.

  16. Decoding hand gestures from primary somatosensory cortex using high-density ECoG.

    Science.gov (United States)

    Branco, Mariana P; Freudenburg, Zachary V; Aarnoutse, Erik J; Bleichner, Martin G; Vansteensel, Mariska J; Ramsey, Nick F

    2017-02-15

    Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Still, target areas for BCI are not confined to M1, and more brain regions may provide suitable BCI control signals. A logical candidate is the primary somatosensory cortex (S1), which not only shares similar somatotopic organization to M1, but also has been suggested to have a role beyond sensory feedback during movement execution. Here, we investigated whether four complex hand gestures, taken from the American sign language alphabet, can be decoded exclusively from S1 using both spatial and temporal information. For decoding, we used the signal recorded from a small patch of cortex with subdural high-density (HD) grids in five patients with intractable epilepsy. Notably, we introduce a new method of trial alignment based on the increase of the electrophysiological response, which virtually eliminates the confounding effects of systematic and non-systematic temporal differences within and between gestures execution. Results show that S1 classification scores are high (76%), similar to those obtained from M1 (74%) and sensorimotor cortex as a whole (85%), and significantly above chance level (25%). We conclude that S1 offers characteristic spatiotemporal neuronal activation patterns that are discriminative between gestures, and that it is possible to decode gestures with high accuracy from a very small patch of cortex using subdurally implanted HD grids. The feasibility of decoding hand gestures using HD-ECoG grids encourages further investigation of implantable BCI systems for direct interaction between the brain and external devices with multiple degrees of freedom. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Long-term storage of waste ion-exchange resins in high-density polyethylene containers

    International Nuclear Information System (INIS)

    Soo, P.; Milian, L.W.

    1993-01-01

    This research effort is being carried out for the Empire Static Electric Energy Research Corporation (ESEERCO) to evaluate the use of high-density polyethylene (HDPE) as a container material for the extended storage of low-level radioactive waste ion-exchange resins. This need arises because of the possibility that a new disposal site may not be commissioned soon enough for wastes to be shipped away. If the wastes are to be stored for periods greater than five years application to the NRC for extended storage must include an analysis of the integrity of the container and its retrievability. In order to ensure that New York State utilities have the necessary database to include in such an application, ESEERCO has contracted with Brookhaven National Laboratory (BNL) to quantify the integrity of HDPE containers for resin storage periods in excess of five years. Based on past BNL research it is considered that three procedural steps should be implemented if a container is to qualify for long-term use. These are: (a) Determine storage conditions and state which degradation modes are likely to be applicable; (b) Specify container performance criteria that must be met for safe storage; and (c) Carry out testing and analyses to demonstrate that these requirements will be met over the storage period. It is envisioned that the study will provide the information needed to determine if the current, inexpensive HDPE containers in use will serve effectively for extended storage. This will be done by quantifying anticipated degradation rates and specifying means to retard their progress

  18. Rice husk ash – A valuable reinforcement for high density polyethylene

    International Nuclear Information System (INIS)

    Ayswarya, E.P.; Vidya Francis, K.F.; Renju, V.S.; Thachil, Eby Thomas

    2012-01-01

    Highlights: ► RHA is formed from the incineration of rice husk. ► RHA is mainly a mixture of silica with various metallic compounds. ► RHA is a valuable reinforcing material for HDPE. ► RHA can be incorporated into HDPE by the melt blending process. ► The best mechanical properties are observed at 1.5% RHA and 15% compatibilizer. -- Abstract: This paper presents the results of a study on the use of rice husk ash (RHA) for property modification of high density polyethylene (HDPE). Rice husk is a waste product of the rice processing industry. It is used widely as a fuel which results in large quantities of RHA. Here, the characterization of RHA has been done with the help of X-ray diffraction (XRD), Inductively Coupled Plasma Atomic Emission Spectroscopy (ICPAES), light scattering based particle size analysis, Fourier transform infrared spectroscopy (FTIR) and Scanning Electron Microscope (SEM). Most reports suggest that RHA when blended directly with polymers without polar groups does not improve the properties of the polymer substantially. In this study RHA is blended with HDPE in the presence of a compatibilizer. The compatibilized HDPE-RHA blend has a tensile strength about 18% higher than that of virgin HDPE. The elongation-at-break is also higher for the compatibilized blend. TGA studies reveal that uncompatibilized as well as compatibilized HDPE-RHA composites have excellent thermal stability. The results prove that RHA is a valuable reinforcing material for HDPE and the environmental pollution arising from RHA can be eliminated in a profitable way by this technique.

  19. Kinetic studies of co-pyrolysis of rubber seed shell with high density polyethylene

    International Nuclear Information System (INIS)

    Chin, Bridgid Lai Fui; Yusup, Suzana; Al Shoaibi, Ahmed; Kannan, Pravin; Srinivasakannan, Chandrasekar; Sulaiman, Shaharin Anwar

    2014-01-01

    Highlights: • Co-pyrolysis of biomass and plastic waste in thermogravimetric analyzer. • Investigation of thermal degradation behavior in different feedstocks. • Synergistic effect of the biomass and plastic waste mixture is investigated. • Kinetic parameters using one step integral method are determined. - Abstract: This paper investigates the thermal degradation behavior of rubber seed shell (RSS), high density polyethylene (HDPE), and the HDPE/RSS mixtures (0.2:0.8 weight ratio) using thermogravimetric analyzer under non-isothermal condition in argon atmosphere at flowrate of 100 ml min −1 . Cellulose, hemicellulose, and lignin are also analyzed in this study for comparison of pyrolysis behavior with RSS. The experiments were conducted at different heating rates of 10, 20, 30, and 50 K min −1 in the temperature range of 323–1173 K. The kinetic data is generated based on first order rate of reaction. It is observed that the thermal degradation behavior of the main components in biomass such as hemicellulose, cellulose, and lignin differs during pyrolysis process due to the structural differences that leads to distinctive pathways of degradation of feedstock. It is found that there are one, two, and three stages of decomposition occurring in HDPE, RSS, and HDPE/RSS mixtures respectively during the pyrolysis process. The remaining solid residue increases with an increase in heating rate regardless of the type of samples used. The activation energies (E A ) for RSS, HDPE, HDPE/RSS mixtures are 46.94–63.21, 242.13–278.14, and 49.14–83.11 kJ mol −1 respectively for the range of heating rate studied

  20. Electron beam irradiation process applied to primary and secondary recycled high density polyethylene

    International Nuclear Information System (INIS)

    Cardoso, Jéssica R.; Moura, Eduardo de; Geraldo, Áurea B.C.

    2017-01-01

    Plastic bags, packaging and furniture items are examples of plastic utilities always present in life. However, the end-of-life of plastics impacts the environment because of this ubiquity and also often their high degradation time. Recycling processes are important in this scenario because they offer many solutions to this problem. Basically, four ways are known for plastic recycling: primary recycling, which consists in re-extrusion of clean plastic scraps from a production plant; secondary recycling, that uses end-of-life products that generally are reduced in size by extrusion to obtain a more desirable shape for reprocessing (pellets and powder); tertiary recover which is related to thermo-chemical methods to produce fuels and petrochemical feedstock; and quaternary route, that is related to energy recovery and it is done in appropriate reactors. In this work, high density polyethylene (HDPE) was recovered to simulate empirically the primary and secondary recycling ways using materials which ranged from pristine to 20-fold re-extrused materials. The final 20-fold recycled thermoplastic was irradiated in an electron beam accelerator under a dose rate of 22.4 kGy/s and absorbed doses of 50 kGy and 100 kGy. The characterization of HDPE in distinct levels of recovering was performed by infrared spectroscopy (FTIR) and thermogravimetric degradation. In the HDPE recycling, degradation and crosslinking are consecutive processes; degradation is very noticeable in the 20-fold recycled product. Despite this, the 20-fold recycled product presents crosslinking after irradiation process and the post-irradiation product presents similarities in spectroscopic and thermal degradation characteristics of pristine, irradiated HDPE. These results are discussed. (author)

  1. Co-pyrolysis of waste newspaper with high-density polyethylene: Synergistic effect and oil characterization

    International Nuclear Information System (INIS)

    Chen, Weimin; Shi, Shukai; Zhang, Jun; Chen, Minzhi; Zhou, Xiaoyan

    2016-01-01

    Highlights: • Synergistic effect during co-pyrolysis occurred at 400–500 °C. • Oil yield from co-pyrolysis was increased by 31.59% compared to theoretical data. • Viscosity and T.A.N. of co-pyrolysis oil were decreased by 75.96% and 216.04%. • Synergistic effect was determined by altering the compounds content in derived oil. - Abstract: Biomass from waste newspaper (WP) was first co-pyrolyzed with high-density polyethylene (HDPE) in order to enhance the oil yield and its fuel properties. The synergistic effects during co-pyrolysis were investigated in terms of entire pyrolysis process, products yield and properties of liquid products (aqueous phase and oil phase) using thermogravimetric analysis coupled with infrared spectroscopy (TG-FTIR), physical properties analysis, elemental analysis, Fourier transform infrared spectroscopy (FT-IR), and gas chromatography/mass spectrometry (GC/MS). The results showed that synergistic effect occurred at 400–500 °C resulting in an obviously increase in oil phase by 31.59% as compared to theoretical data. Positive synergistic effects on fuel properties of co-pyrolysis oil were observed, especially demonstrating dramatically decrease in viscosity and total acid number by 75.96% and 216.04% in comparison to theoretical data. WP pyrolyzed alone gives mainly oxygenated compounds in its derived oil, while HDPE give hydrocarbons. No cross reaction products appeared in co-pyrolysis oil, implying that the synergistic effects were determined by altering its compounds content rather than generating cross reaction products. Unfortunately, aqueous phase and oil phase exhibit similar composition.

  2. High density turbulent plasma processes from a shock tube. Final performance report

    International Nuclear Information System (INIS)

    Johnson, J.A. III.

    1997-01-01

    A broad-based set of measurements has begun on high density turbulent plasma processes. This includes determinations of new plasma physics and the initiation of work on new diagnostics for collisional plasmas as follows: (1) A transient increase is observed in both the spectral energy decay rate and the degree of chaotic complexity at the interface of a shock wave and a turbulent ionized gas. Even though the gas is apparently brought to rest by the shock wave, no evidence is found either of prompt relaminarization or of any systematic influence of end-wall material thermal conductivities on the turbulence parameters. (2) Point fluorescence emissions and averaged spectral line evolutions in turbulent plasmas produced in both the primary and the reflected shock wave flows exhibit ergodicity in the standard turbulence parameters. The data show first evidence of a reverse energy cascade in the collisional turbulent plasma. This suggests that the fully turbulent environment can be described using a stationary state formulation. In these same data, the author finds compelling evidence for a turbulent Stark effect on neutral emission lines in these data which is associated with evidence of large coherent structures and dominant modes in the Fourier analyses of the fluctuations in the optical spectra. (3) A neutral beam generator has been assembled by coupling a Colutron Ion Gun to a charge exchange chamber. Beam-target collisions where the target species is neutral and the beam is either singly charged or neutral have been performed using argon as the working gas. Spectral analysis of the emission shows specific radiative transitions characteristic of both Ar I and Ar II, indicating that some ionization of the target gas results. Gas and plasma parameters such as density, pressure, temperature and flow velocity and their fluctuations can now be followed in real time by spectroscopic analysis of carefully chosen radiative emissions

  3. Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction*

    Science.gov (United States)

    Gu, Xiaodong; Huang, Ying; Levison, Bruce S.; Gerstenecker, Gary; DiDonato, Anthony J.; Hazen, Leah B.; Lee, Joonsue; Gogonea, Valentin; DiDonato, Joseph A.; Hazen, Stanley L.

    2016-01-01

    Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated protein with atherosclerosis-protective and systemic anti-oxidant functions. We recently showed that PON1, myeloperoxidase, and HDL bind to one another in vivo forming a functional ternary complex (Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., Zhang, R., Li, X. M., Didonato, A. J., Gogonea, V., Tang, W. H., et al. (2013) J. Clin. Invest. 123, 3815–3828). However, specific residues on PON1 involved in the HDL-PON1 interaction remain unclear. Unambiguous identification of protein residues involved in docking interactions to lipid surfaces poses considerable methodological challenges. Here we describe a new strategy that uses a novel synthetic photoactivatable and click chemistry-taggable phospholipid probe, which, when incorporated into HDL, was used to identify amino acid residues on PON1 that directly interact with the lipoprotein phospholipid surface. Several specific PON1 residues (Leu-9, Tyr-185, and Tyr-293) were identified through covalent cross-links with the lipid probes using affinity isolation coupled to liquid chromatography with on-line tandem mass spectrometry. Based upon the crystal structure for PON1, the identified residues are all localized in relatively close proximity on the surface of PON1, defining a domain that binds to the HDL lipid surface. Site-specific mutagenesis of the identified PON1 residues (Leu-9, Tyr-185, and Tyr-293), coupled with functional studies, reveals their importance in PON1 binding to HDL and both PON1 catalytic activity and stability. Specifically, the residues identified on PON1 provide important structural insights into the PON1-HDL interaction. More generally, the new photoactivatable and affinity-tagged lipid probe developed herein should prove to be a valuable tool for identifying contact sites supporting protein interactions with lipid interfaces such as found on cell membranes

  4. Does high-density lipoprotein protect vascular function in healthy pregnancy?

    Science.gov (United States)

    Sulaiman, Wan N Wan; Caslake, Muriel J; Delles, Christian; Karlsson, Helen; Mulder, Monique T; Graham, Delyth; Freeman, Dilys J

    2016-04-01

    The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit of its functionality rather than its plasma concentration, exerts protective effects on the vascular endothelium. HDL has vasodilatory, antioxidant, anti-thrombotic and anti-inflammatory effects, and can protect against endothelial cell damage. In pregnancy, the plasma HDL concentration starts to rise at 10 weeks of gestation, peaking at 20 weeks. The initial rise in plasma HDL occurs around the time of the establishment of the feto-placental circulation, a time when the trophoblast plugs in the maternal spiral arteries are released, generating oxidative stress. Thus there is the intriguing possibility that new HDL of improved function is synthesized around the time of the establishment of the feto-placental circulation. In obese pregnancy and, to a greater extent, in pre-eclampsia, plasma HDL levels are significantly decreased and maternal vascular function is reduced. Wire myography studies have shown an association between the plasma content of apolipoprotein AI, the major protein constituent of HDL, and blood vessel relaxation. These observations lead us to hypothesize that HDL concentration, and function, increases in pregnancy in order to protect the maternal vascular endothelium and that in pre-eclampsia this fails to occur. © 2016 Authors; published by Portland Press Limited.

  5. Anatomical traits related to stress in high density populations of Typha angustifolia L. (Typhaceae

    Directory of Open Access Journals (Sweden)

    F. F. Corrêa

    Full Text Available Abstract Some macrophytes species show a high growth potential, colonizing large areas on aquatic environments. Cattail (Typha angustifolia L. uncontrolled growth causes several problems to human activities and local biodiversity, but this also may lead to competition and further problems for this species itself. Thus, the objective of this study was to investigate anatomical modifications on T. angustifolia plants from different population densities, once it can help to understand its biology. Roots and leaves were collected from natural populations growing under high and low densities. These plant materials were fixed and submitted to usual plant microtechnique procedures. Slides were observed and photographed under light microscopy and images were analyzed in the UTHSCSA-Imagetool software. The experimental design was completely randomized with two treatments and ten replicates, data were submitted to one-way ANOVA and Scott-Knott test at p<0.05. Leaves from low density populations showed higher stomatal density and index. These modifications on stomatal characteristics were more evident on the leaf abaxial surface. Plants from low density populations showed thicker mesophyll and higher proportion of aerenchymal area. Roots from low density populations showed a higher proportion of the vascular cylinder. Whereas, plants from higher density populations showed greater thickness of the endodermis, exodermis, phloem and root cortex. Higher density populations showed a higher proportion of aerenchymal gaps in the root cortex. Therefore, cattail plants from populations growing under high density population show anatomical traits typical of plants under stress, which promotes the development of less functional anatomical modifications to aquatic environments.

  6. High-density transcriptional initiation signals underline genomic islands in bacteria.

    Directory of Open Access Journals (Sweden)

    Qianli Huang

    Full Text Available Genomic islands (GIs, frequently associated with the pathogenicity of bacteria and having a substantial influence on bacterial evolution, are groups of "alien" elements which probably undergo special temporal-spatial regulation in the host genome. Are there particular hallmark transcriptional signals for these "exotic" regions? We here explore the potential transcriptional signals that underline the GIs beyond the conventional views on basic sequence composition, such as codon usage and GC property bias. It showed that there is a significant enrichment of the transcription start positions (TSPs in the GI regions compared to the whole genome of Salmonella enterica and Escherichia coli. There was up to a four-fold increase for the 70% GIs, implying high-density TSPs profile can potentially differentiate the GI regions. Based on this feature, we developed a new sliding window method GIST, Genomic-island Identification by Signals of Transcription, to identify these regions. Subsequently, we compared the known GI-associated features of the GIs detected by GIST and by the existing method Islandviewer to those of the whole genome. Our method demonstrates high sensitivity in detecting GIs harboring genes with biased GI-like function, preferred subcellular localization, skewed GC property, shorter gene length and biased "non-optimal" codon usage. The special transcriptional signals discovered here may contribute to the coordinate expression regulation of foreign genes. Finally, by using GIST, we detected many interesting GIs in the 2011 German E. coli O104:H4 outbreak strain TY-2482, including the microcin H47 system and gene cluster ycgXEFZ-ymgABC that activates the production of biofilm matrix. The aforesaid findings highlight the power of GIST to predict GIs with distinct intrinsic features to the genome. The heterogeneity of cumulative TSPs profiles may not only be a better identity for "alien" regions, but also provide hints to the special

  7. High density, multi-range analog output Versa Module Europa board for control system applications.

    Science.gov (United States)

    Singh, Kundan; Das, Ajit Lal

    2014-01-01

    A new VMEDAC64, 12-bit 64 channel digital-to-analog converter, a Versa Module Europa (VME) module, features 64 analog voltage outputs with user selectable multiple ranges, has been developed for control system applications at Inter University Accelerator Centre. The FPGA (Field Programmable Gate Array) is the module's core, i.e., it implements the DAC control logic and complexity of VMEbus slave interface logic. The VMEbus slave interface and DAC control logic are completely designed and implemented on a single FPGA chip to achieve high density of 64 channels in a single width VME module and will reduce the module count in the control system applications, and hence will reduce the power consumption and cost of overall system. One of our early design goals was to develop the VME interface such that it can be easily integrated with the peripheral devices and satisfy the timing specifications of VME standard. The modular design of this module reduces the amount of time required to develop other custom modules for control system. The VME slave interface is written as a single component inside FPGA which will be used as a basic building block for any VMEbus interface project. The module offers multiple output voltage ranges depending upon the requirement. The output voltage range can be reduced or expanded by writing range selection bits in the control register. The module has programmable refresh rate and by default hold capacitors in the sample and hold circuit for each channel are charged periodically every 7.040 ms (i.e., update frequency 284 Hz). Each channel has software controlled output switch which disconnects analog output from the field. The modularity in the firmware design on FPGA makes the debugging very easy. On-board DC/DC converters are incorporated for isolated power supply for the analog section of the board.

  8. Structural insights into high density lipoprotein: Old models and new facts

    Directory of Open Access Journals (Sweden)

    Valentin eGogonea

    2016-01-01

    Full Text Available The physiological link between circulating high density lipoprotein (HDL levels and cardiovascular disease is well documented, albeit its intricacies are not well understood. An improved appreciation of HDL function and overall role in vascular health and disease requires at its foundation a better understanding of the lipoprotein's molecular structure, its formation, and its process of maturation through interactions with various plasma enzymes and cell receptors that intervene along the pathway of reverse cholesterol transport. This review focuses on summarizing recent developments in the field of lipid free apoA-I and HDL structure, with emphasis on new insights revealed by newly published nascent and spherical HDL models constructed by combining low resolution structures obtained from small angle neutron scattering (SANS with contrast variation and geometrical constraints derived from hydrogen-deuterium exchange (HDX, crosslinking mass spectrometry, electron microscopy, Förster resonance energy transfer, and electron spin resonance. Recently published low resolution structures of nascent and spherical HDL obtained from SANS with contrast variation and isotopic labeling of apolipoprotein A-I (apoA-I will be critically reviewed and discussed in terms of how they accommodate existing biophysical structural data from alternative approaches. The new low resolution structures revealed and also provided some answers to long standing questions concerning lipid organization and particle maturation of lipoproteins. The review will discuss the merits of newly proposed SANS based all atom models for nascent and spherical HDL, and compare them with accepted models. Finally, naturally occurring and bioengineered mutations in apoA-I, and their impact on HDL phenotype, are reviewed and discuss together with new therapeutics employed for restoring HDL function.

  9. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

    Science.gov (United States)

    Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M

    2013-11-26

    Abnormal glucose metabolism is a central feature of disorders with increased rates of cardiovascular disease. Low levels of high-density lipoprotein (HDL) are a key predictor for cardiovascular disease. We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle. ApoA-I ko mice exhibited fasting hyperglycemia and impaired glucose tolerance test compared with wild-type mice. Mitochondria isolated from gastrocnemius muscle of apoA-I ko mice displayed markedly blunted ATP synthesis. Endurance capacity during exercise exhaustion test was impaired in apoA-I ko mice. HDL directly enhanced glucose oxidation by increasing glycolysis and mitochondrial respiration rate in C2C12 muscle cells. ApoA-I tg mice exhibited lower fasting glucose levels, improved glucose tolerance test, increased lactate levels, reduced fat mass, associated with protection against age-induced decline of endurance capacity compared with wild-type mice. Circulating levels of fibroblast growth factor 21, a novel biomarker for mitochondrial respiratory chain deficiencies and inhibitor of white adipose lipolysis, were significantly reduced in apoA-I tg mice. Consistent with an increase in glucose utilization of skeletal muscle, genetically increased HDL and apoA-I levels in mice prevented high-fat diet-induced impairment of glucose homeostasis. In view of impaired mitochondrial function and decreased HDL levels in type 2 diabetes mellitus, our findings indicate that HDL-raising therapies may preserve muscle mitochondrial function and address key aspects of type 2 diabetes mellitus beyond cardiovascular disease.

  10. Performance of high-density-carbon (HDC) ablator implosion experiments on the National Ignition Facility (NIF)

    Science.gov (United States)

    MacKinnon, Andy

    2013-10-01

    A series of experiments on the National Ignition Facility (NIF) have been performed to measure high-density carbon (HDC) ablator performance for indirect drive inertial confinement fusion (ICF). HDC is a very promising ablator material; being 3x denser than plastic, it absorbs more hohlraum x-rays, leading to higher implosion efficiency. For the HDC experiments the NIF laser generated shaped laser pulses with peak power up to 410 TW and total energy of 1.3 MJ. Pulse shapes were designed to drive 2, 3 or 4 shocks in cryogenic layered implosions. The 2-shock pulse, with a designed fuel adiabat of ~3 is 6-7ns in duration, allowing use of near vacuum hohlraums, which greatly increases the coupling efficiency due to low backscatter losses. Excellent results were obtained for 2,3 and 4 shock pulses. In particular a deuterium-tritium gas filled HDC capsule driven by a 4-shock pulse in a gas-filled hohlraum produced a neutron yield of 1.6 × 1015, a record for a non-cryogenically layered capsule driven by a gas-filled hohlraum. The first 2-shock experiment used a vacuum hohlraum to drive a DD gas filled HDC capsule with a 6.5 ns, laser pulse. This hohlraum was 40% more efficient than the gas-filled counterpart used for 3 and 4 shock experiments, producing near 1D performance at 11 x convergence ratio, peak radiation temperature of 317 eV, 98% laser-hohlraum coupling, and DD neutron yield of 2.2e13, a record for a laser driven DD implosion. The HDC campaigns will be presented, including options for pushing towards the alpha dominated regime. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  11. Cellular localization and characterization of proteins that bind high density lipoprotein.

    Science.gov (United States)

    Hokland, B; Mendez, A J; Oram, J F

    1992-09-01

    High density lipoprotein (HDL) stimulates excretion of excess intracellular cholesterol from cells, presumably by interacting with a cell-surface receptor. A 110 kDa membrane protein that is a candidate for the HDL receptor has been identified by ligand blot analysis. In this study we determined the cellular localization of this and other HDL-binding proteins and characterized their properties. The plasma membranes (PM) of cultured bovine aortic endothelial cells were labeled with trace amounts of [3H]cholesterol, and cell homogenates were fractionated on sucrose and Percoll gradients. Ligand blot analysis of homogenates of cultured bovine aortic endothelial cells demonstrated that cells contain multiple proteins that bind HDL3, including a major membrane protein with an apparent M(r) of 110 kDa and two minor ones with M(r) of 105 and 130 kDa. The gradient distribution of the 105, 110, and 130 kDa HDL-binding proteins mirrored that of labeled cholesterol and 5'-nucleotidase, both PM markers. Treatment of intact cells with the water-soluble cross-linker bis(sulfosuccinimidyl)suberate abolished the HDL binding activity of the 110 and 130 kDa proteins but not that of the 105 kDa protein. These findings suggest that the 105, 110, and 130 kDa HDL-binding proteins are localized to the PM and that at least two of these proteins are exposed to the extracellular fluid. Solubilized 110 and 130 kDa proteins were retained on wheat-germ agglutinin and abrin lectin columns, showing that they are glycoproteins. The cellular localization and physical properties of the 110 and 130 kDa proteins suggest that they may play a role in binding of HDL to the cell surface.

  12. Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid

    Directory of Open Access Journals (Sweden)

    Dwi Laksono Adiputro

    2013-04-01

    Full Text Available Background In cardiovascular medicine, Garcinia mangostana has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The effect of Garcinia mangostana on hyperlipidemia is unknown. The aim of this study was to evaluate the effect of an ethanolic extract of Garcinia mangostana pericarp on lipid profile in rats fed a high lipid diet. Methods A total of 40 rats were divided into five groups control, high lipid diet, and high lipid diet + ethanolic extract of Garcinia mangostana pericarp at dosages of 200, 400, and 800 mg/kg body weight. The control group received a standard diet for 60 days. The high lipid diet group received standard diet plus egg yolk, goat fat, cholic acid, and pig fat for 60 days with or without ethanolic extract of Garcinia mangostana pericarp by the oral route. After 60 days, rats were anesthesized with ether for collection of blood by cardiac puncture. Analysis of blood lipid profile comprised colorimetric determination of cholesterol, triglyceride, low density lipoprotein (LDL, and high density lipoprotein (HDL. Results From the results of one-way ANOVA it was concluded that there were significant between-group differences in cholesterol, trygliceride, LDL, and HDL levels (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly decreased cholesterol, trygliceride, and LDL levels, starting at 400 mg/kg body weight (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly increased HDL level starting at 200 mg/kg body weight (p=0.000. Conclusion Ethanolic extract of Garcinia mangostana pericarp has a beneficial effect on lipid profile in rats on a high lipid diet.

  13. Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid

    Directory of Open Access Journals (Sweden)

    Dwi Laksono Adiputro

    2015-12-01

    Full Text Available BACKGROUND In cardiovascular medicine, Garcinia mangostana has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The effect of Garcinia mangostana on hyperlipidemia is unknown. The aim of this study was to evaluate the effect of an ethanolic extract of Garcinia mangostana pericarp on lipid profile in rats fed a high lipid diet. METHODS A total of 40 rats were divided into five groups control, high lipid diet, and high lipid diet + ethanolic extract of Garcinia mangostana pericarp at dosages of 200, 400, and 800 mg/kg body weight. The control group received a standard diet for 60 days. The high lipid diet group received standard diet plus egg yolk, goat fat, cholic acid, and pig fat for 60 days with or without ethanolic extract of Garcinia mangostana pericarp by the oral route. After 60 days, rats were anesthesized with ether for collection of blood by cardiac puncture. Analysis of blood lipid profile comprised colorimetric determination of cholesterol, triglyceride, low density lipoprotein (LDL, and high density lipoprotein (HDL. RESULTS From the results of one-way ANOVA it was concluded that there were significant between-group differences in cholesterol, trygliceride, LDL, and HDL levels (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly decreased cholesterol, trygliceride, and LDL levels, starting at 400 mg/kg body weight (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly increased HDL level starting at 200 mg/kg body weight (p=0.000. CONCLUSION Ethanolic extract of Garcinia mangostana pericarp has a beneficial effect on lipid profile in rats on a high lipid diet.

  14. High-density grids for efficient data collection from multiple crystals.

    Science.gov (United States)

    Baxter, Elizabeth L; Aguila, Laura; Alonso-Mori, Roberto; Barnes, Christopher O; Bonagura, Christopher A; Brehmer, Winnie; Brunger, Axel T; Calero, Guillermo; Caradoc-Davies, Tom T; Chatterjee, Ruchira; Degrado, William F; Fraser, James S; Ibrahim, Mohamed; Kern, Jan; Kobilka, Brian K; Kruse, Andrew C; Larsson, Karl M; Lemke, Heinrik T; Lyubimov, Artem Y; Manglik, Aashish; McPhillips, Scott E; Norgren, Erik; Pang, Siew S; Soltis, S M; Song, Jinhu; Thomaston, Jessica; Tsai, Yingssu; Weis, William I; Woldeyes, Rahel A; Yachandra, Vittal; Yano, Junko; Zouni, Athina; Cohen, Aina E

    2016-01-01

    Higher throughput methods to mount and collect data from multiple small and radiation-sensitive crystals are important to support challenging structural investigations using microfocus synchrotron beamlines. Furthermore, efficient sample-delivery methods are essential to carry out productive femtosecond crystallography experiments at X-ray free-electron laser (XFEL) sources such as the Linac Coherent Light Source (LCLS). To address these needs, a high-density sample grid useful as a scaffold for both crystal growth and diffraction data collection has been developed and utilized for efficient goniometer-based sample delivery at synchrotron and XFEL sources. A single grid contains 75 mounting ports and fits inside an SSRL cassette or uni-puck storage container. The use of grids with an SSRL cassette expands the cassette capacity up to 7200 samples. Grids may also be covered with a polymer film or sleeve for efficient room-temperature data collection from multiple samples. New automated routines have been incorporated into the Blu-Ice/DCSS experimental control system to support grids, including semi-automated grid alignment, fully automated positioning of grid ports, rastering and automated data collection. Specialized tools have been developed to support crystallization experiments on grids, including a universal adaptor, which allows grids to be filled by commercial liquid-handling robots, as well as incubation chambers, which support vapor-diffusion and lipidic cubic phase crystallization experiments. Experiments in which crystals were loaded into grids or grown on grids using liquid-handling robots and incubation chambers are described. Crystals were screened at LCLS-XPP and SSRL BL12-2 at room temperature and cryogenic temperatures.

  15. Feedback controlled, reactor relevant, high-density, high-confinement scenarios at ASDEX Upgrade

    Science.gov (United States)

    Lang, P. T.; Blanken, T. C.; Dunne, M.; McDermott, R. M.; Wolfrum, E.; Bobkov, V.; Felici, F.; Fischer, R.; Janky, F.; Kallenbach, A.; Kardaun, O.; Kudlacek, O.; Mertens, V.; Mlynek, A.; Ploeckl, B.; Stober, J. K.; Treutterer, W.; Zohm, H.; ASDEX Upgrade Team

    2018-03-01

    One main programme topic at the ASDEX Upgrade all-metal-wall tokamak is development of a high-density regime with central densities at reactor grade level while retaining high-confinement properties. This required development of appropriate control techniques capable of coping with the pellet tool, a powerful means of fuelling but one which presented challenges to the control system for handling of related perturbations. Real-time density profile control was demonstrated, raising the core density well above the Greenwald density while retaining the edge density in order to avoid confinement losses. Recently, a new model-based approach was implemented that allows direct control of the central density. Investigations focussed first on the N-seeding scenario owing to its proven potential to yield confinement enhancements. Combining pellets and N seeding was found to improve the divertor buffering further and enhance the operational range accessible. For core densities up to about the Greenwald density, a clear improvement with respect to the non-seeding reference was achieved; however, at higher densities this benefit is reduced. This behaviour is attributed to recurrence of an outward shift of the edge density profile, resulting in a reduced peeling-ballooning stability. This is similar to the shift seen during strong gas puffing, which is required to prevent impurity influx in ASDEX Upgrade. First tests indicate that highly-shaped plasma configurations like the ITER base-line scenario, respond very well to pellet injection, showing efficient fuelling with no measurable impact on the edge density profile.

  16. Gap formation processes in a high-density plasma opening switch

    International Nuclear Information System (INIS)

    Grossmann, J.M.; Swanekamp, S.B.; Ottinger, P.F.; Commisso, R.J.; Hinshelwood, D.D.; Weber, B.V.

    1995-01-01

    A gap opening process in plasma opening switches (POS) is examined with the aid of numerical simulations. In these simulations, a high density (n e =10 14 --5x10 15 cm -3 ) uniform plasma initially bridges a small section of the coaxial transmission line of an inductive energy storage generator. A short section of vacuum transmission line connects the POS to a short circuit load. The results presented here extend previous simulations in the n e =10 12 --10 13 cm -3 density regime. The simulations show that a two-dimensional (2-D) sheath forms in the plasma near a cathode. This sheath is positively charged, and electrostatic sheath potentials that are large compared to the anode--cathode voltage develop. Initially, the 2-D sheath is located at the generator edge of the plasma. As ions are accelerated out of the sheath, it retains its original 2-D structure, but migrates axially toward the load creating a magnetically insulated gap in its wake. When the sheath reaches the load edge of the POS, the POS stops conducting current and the load current increases rapidly. At the end of the conduction phase a gap exists in the POS whose size is determined by the radial dimensions of the 2-D sheath. Simulations at various plasma densities and current levels show that the radial size of the gap scales roughly as B/n e , where B is the magnetic field. The results of this work are discussed in the context of long-conduction-time POS physics, but exhibit the same physical gap formation mechanisms as earlier lower density simulations more relevant to short-conduction-time POS. copyright 1995 American Institute of Physics

  17. Effect of expanded graphite on the phase change materials of high density polyethylene/wax blends

    International Nuclear Information System (INIS)

    AlMaadeed, M.A.; Labidi, Sami; Krupa, Igor; Karkri, Mustapha

    2015-01-01

    Highlights: • Expanded graphite (EG) and low melting point (42.3 °C) wax were added to HDPE to form phase change material. • EG was well dispersed in the composites and did not affect the melting or crystallization of the HDPE matrix. • EG increased the thermal stability of the composites by reducing chain mobility and inhibiting degradation. • The addition of a relatively small quantity of EG enhances the heat conduction in the composite. • HDPE/40% RT42 that contained up to 15% EG demonstrated excellent mechanical and thermal properties and can be used as PCM. - Abstract: Phase change materials fabricated from high density polyethylene (HDPE) blended with 40 or 50 wt% commercial wax (melting point of 43.08 °C) and up to 15 wt% expanded graphite (EG) were studied. Techniques including scanning electron microscope (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and an experimental device to measure diffusivity and conductivity (DICO) were used to determine the microstructural, mechanical and thermal properties of the composites. The composites possessed good mechanical properties. Additionally, no leaching was observed during material processing or characterization. Although the Young’s modulus increased with the addition of EG, no significant changes in tensile strength were detected. The maximum Young’s modulus achieved was 650 MPa for the HDPE/40% wax composite with 15 wt% EG. The EG was well dispersed within the composites and did not affect the melting or crystallization of the HDPE matrix. The incorporation of EG increased the thermal stability of the composites by reducing chain mobility and inhibiting degradation. The intensification of thermal conductivity occurred with increasing fractions of EG, which was attributed to the high thermal conductivity of graphite. The maximum quantity of heat stored by latent heat was found for the HDPE/40% wax composite with EG. The addition of a relatively small quantity

  18. Bremsstrahlung spectra for Al, Cs, and Au atoms in high-temperature, high-density plasmas

    International Nuclear Information System (INIS)

    Kim, L.; Pratt, R.H.; Tseng, H.K.

    1985-01-01

    Results are presented from a numerical calculation for the bremsstrahlung spectrum and Gaunt factors of Al, Cs, and Au atoms in high-temperature (-T), high-density (-rho) plasmas. Plasma temperatures kT = 0.1 and 1.0 keV and plasma densities rho = rho 0 (the normal solid density) and rho = 100rho 0 are considered. This allows us to determine the generality and identify the origins of features which we had previously identified in calculations for Cs. We also now present results for the total energy loss of an electron in such a plasma. We use a relativistic multipole code which treats the bremsstrahlung process as a single-electron transition in a static screened central potential. We take for the static potential corresponding to an atom in a hot dense plasma the finite-temperature, finite-density Thomas-Fermi model. This approach corresponds to an average atom in local thermodynamic equilibrium. In comparison to isolated-neutral-atom results we observe general suppression of cross sections and a particular suppression in the tip region of the spectrum. Within this model, both superscreening and shape resonances are found in the circumstances of extreme density. At more normal densities and except for the soft-photon end, the spectrum at these energies for an atom in a hot plasma (characterized by an average degree of ionization) can be well represented by the spectrum of the corresponding isolated ion, which has a similar potential shape at the distances which characterize the process

  19. Comparison of human plasma low- and high-density lipoproteins as substrates for lecithin: cholesterol acyltransferase.

    Science.gov (United States)

    Barter, P J; Hopkins, G J; Gorjatschko, L

    1984-01-17

    A recent observation that lecithin: cholesterol acyltransferase (EC 2.3.1.43) interacts with both low-density lipoproteins (LDL) and high-density lipoproteins (HDL) in human plasma is in apparent conflict with an earlier finding that the purified enzyme, while highly reactive with isolated HDL, was only minimally reactive with LDL. There is evidence, however, that lecithin: cholesterol acyltransferase may exist physiologically as a component of a complex with other proteins and that studies with the isolated enzyme may therefore provide misleading results. Consequently, interactions of the enzyme with isolated human lipoproteins have been re-examined in incubations containing lecithin: cholesterol acyltransferase as a component of human lipoprotein-free plasma in which a physiologically active complex of the enzyme with other proteins may have been preserved. In this system there was a ready esterification of the free cholesterol associated with both LDL and HDL-subfraction 3 (HDL3) in reactions that obeyed typical enzyme-saturation kinetics. For a given preparation of lipoprotein-free plasma the Vmax values with LDL and with HDL3 were virtually identical. The apparent Km for free cholesterol associated with HDL3 was 5.6 X 10(-5) M, while for that associated with LDL it was 4.1 X 10(-4) M. This implied that, in terms of free cholesterol concentration, the affinity of HDL3 for lecithin: cholesterol acyltransferase was about 7-times greater than that of LDL. When expressed in terms of lipoprotein particle concentration, however, it was apparent that the affinity of LDL for the enzyme was considerably greater than that of HDL3. When the lipoprotein fractions were equated in terms of lipoprotein surface area, the apparent affinities of the two fractions for the enzyme were found to be comparable.

  20. Extracting Extensor Digitorum Communis Activation Patterns using High-Density Surface Electromyography

    Directory of Open Access Journals (Sweden)

    Xiaogang eHu

    2015-10-01

    Full Text Available The extensor digitorum communis muscle plays an important role in hand dexterity during object manipulations. This multi-tendinous muscle is believed to be controlled through separate motoneuron pools, thereby forming different compartments that control individual digits. However, due to the complex anatomical variations across individuals and the flexibility of neural control strategies, the spatial activation patterns of the extensor digitorum communis compartments during individual finger extension have not been fully tracked under different task conditions.The objective of this study was to quantify the global spatial activation patterns of the extensor digitorum communis using high-density (7×9 surface electromyogram (EMG recordings. The muscle activation map (based on the root mean square of the EMG was constructed when subjects performed individual four finger extensions at the metacarpophalangeal joint, at different effort levels and under different finger constraints (static and dynamic. Our results revealed distinct activation patterns during individual finger extensions, especially between index and middle finger extensions, although the activation between ring and little finger extensions showed strong covariance. The activation map was relatively consistent at different muscle contraction levels and for different finger constraint conditions. We also found that distinct activation patterns were more discernible in the proximal-distal direction than in the radial-ulnar direction. The global spatial activation map utilizing surface grid EMG of the extensor digitorum communis muscle provides information for localizing individual compartments of the extensor muscle during finger extensions. This is of potential value for identifying more selective control input for assistive devices. Such information can also provide a basis for understanding hand impairment in individuals with neural disorders.

  1. Correlation between Microstructure and Rheological Properties of Broad Molecular Weight Distribution High Density Polyethylenes

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Shirkavand

    2015-03-01

    Full Text Available In this article, the correlation between molecular microstructure and rheological behavior for three different grades of high density polyethylene with broad molecular weight distribution have been investigated. Structural parameters such as Mn, Mw, Mz, molecular weight distribution (MWD and branching index were characterized by high temperature Gel Permeation Chromatography (GPC test. GPC results showed that BL4 and EX3 have bigger weight average molecular weight and narrower molecular weight distribution, respectively. Furthermore,it was found from GPC results that all three HDPE has a broad MWD and EX3 has more short chain branches than two other samples. Rheological characterization was done in a Mechanical Compact Rheometer (MCR in rotational and dynamic modes at both linear and nonlinear viscoelastic region. From rheological characterization the zero shear viscosity (η0, relaxation time and relaxation time distribution, stress relaxation modulus and damping factor were obtained and by utilizing relaxation time spectrum function (h(τ, molecular weight distribution was calculated for each sample and compared with GPC results. The relationship between zero shear viscosity with molecular weight and MWD at 180 ºC obtained. After calculating molecular weight distribution function and average molecular weights using different mixing parameters (β, by choosing β=0.73, a good correlation between molecular parameters obtained from rheological data with those of GPC results was obtained. After calculating stress relaxation modulus and consequently damping factor for each sample, comparing to Doi-Edwards model, it was found that the damping function type C is an appropriate damping function type for selected polyethylenes.

  2. Properties Evaluation of High Density Polyethylene Composite Filled with Bagasse after Accelerated Weathered

    Directory of Open Access Journals (Sweden)

    Peyvand Darabi

    2013-06-01

    Full Text Available Wood plastic composites (WPCs are produced from a mixture of wood (in different sizes and resin (thermoset or thermoplastic. This product has many applications as structural and non-structural materials and since its emerge in market its use received an increasing trend. Adding wood flour to polymer not only improves its mechanical properties compared to net polymer, but also leads to products with moldability characteristics. With increasing demand of WPCs and reduction in forest harvest according to new protecting law of forestry, and lack of raw materials for producers, other lignocelluloses materials replace wood flour. Agricultural by-products such as hemp, coir, rice husk and bagasse (residual from sugar cane extraction are the examples that can be used in WPCs. As the outdoor application of Wood Plastic Composites (WPCs becomes more widespread, the resistance of its products against weathering, particularly ultraviolet (UV light becomes more concerned. When WPCs are exposed to outdoor, ultraviolet (UV light, rain, snow and atmospheric pollution, they will be degraded which is marked by color fade and loss in mechanical properties. Nowadays many manufactures of WPCs use bagasse as a raw material. Their production in different color and shapes are used as arbors and pergolas and also as decorative applications for outdoor uses. However, so far there has been no research done on the effects of weathering on composites made from bagasse. In present study, composites from bagasse and high density polyethylene, with and without pigments in master batch, have been made through extrusion. Then samples were exposed to accelerated weathering for 1440h. After this period of time samples were removed and their chemical, mechanical and surface qualities were studied. The results have shown that using bagasse as filler can relatively reduce the discoloration of weathered samples. Moreover, adding pigments to WPCs can increase colorstability, while it

  3. Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.

    LENUS (Irish Health Repository)

    Yeap, Sherlyn

    2009-11-01

    BACKGROUND: Etiological commonalities are apparent between bipolar disorder and schizophrenia. For example, it is becoming clear that both populations show similar electrophysiological deficits in the auditory domain. Recent studies have also shown robust visual sensory processing deficits in patients with schizophrenia using the event-related potential technique, but this has not been formally tested in those with bipolar disorder. Our goal here was to assess whether early visual sensory processing in patients with bipolar disorder, as indexed by decreased amplitude of the P1 component of the visual evoked potential (VEP), would show a similar deficit to that seen in those with schizophrenia. Since the P1 deficit has already been established as an endophenotype in schizophrenia, a finding of commonality between disorders would raise the possibility that it represents a measure of common genetic liability. METHODS: We visually presented isolated-check stimuli to euthymic patients with a diagnosis of bipolar disorder and age-matched healthy controls within a simple go\\/no-go task and recorded VEPs using high-density (72-channel) electroencephalography. RESULTS: The P1 VEP amplitude was substantially reduced in patients with bipolar disorder, with an effect size of f = 0.56 (large according to Cohen\\'s criteria). LIMITATIONS: Our sample size was relatively small and as such, did not allow for an examination of potential relations between the physiologic measures and clinical measures. CONCLUSION: This reduction in P1 amplitude among patients with bipolar disorder represents a dysfunction in early visual processing that is highly similar to that found repeatedly in patients with schizophrenia and their healthy first-degree relatives. Since the P1 deficit has been related to susceptibility genes for schizophrenia, our results raise the possibility that the deficit may in fact be more broadly related to the development of psychosis and that it merits further

  4. Recycling enhancement with n-bare and qeff in high density discharges on JT-60U

    International Nuclear Information System (INIS)

    Asakura, N.; Shimizu, K.; Hosogane, N.; Itami, K.; Tsuji, S.; Shimada, M.

    1995-01-01

    Quantitative studies of recycling, particle flux and divertor plasma parameters have been made in high density L mode discharges on the JT-60U tokamak, with the ion ∇B drift towards the divertor. The diagnostics used were H α /D α photon emission detectors and a Langmuir probe array. Deuterium particle influx Φ Dα and particle outflux Φ probe measurements were in fairly good agreement in both the inboard and the outboard divertors. The relationship between the particle recycling and the divertor plasma parameters was investigated to clarify the conditions under which a cold and dense divertor plasma was formed. Φ Dα was raised from 10 22 to 10 23 s -1 with increasing n-bar e and q eff . Recycling in the inboard divertor was amplified substantially owing to the appearance of a third peak in the local recycling profile, displace from the separatrix. Numerical results from an interpretative divertor code showed that the particle amplification factor G div in the inboard divertor was larger than that in the outboard divertor, and that both increased with increasing q eff and n-bar e . These results explain the observed dependence of the recycling on the parameters n-bar e and q eff discharges. The maximum electron density n e,div in the outboard divertor was (4-7) x 10 19 m -3 , exceeding n-bar e for high q eff discharges. In the same discharges, the divertor electron temperature T e,div was reduced to about 20 eV before MARFEs were observed. High n-bar e and q eff operation was favourable for obtaining a cold and dense divertor plasma. (author). 39 refs, 21 figs

  5. High-density lipoprotein cholesterol increase and non-cardiovascular mortality: a meta-analysis.

    Science.gov (United States)

    Burillo, Elena; Andres, Eva Maria; Mateo-Gallego, Rocio; Fiddyment, Sarah; Jarauta, Estibaliz; Cenarro, Ana; Civeira, Fernando

    2010-09-01

    Many observational prospective studies have confirmed the inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease. However, the potential benefit of the pharmacological increase in HDL cholesterol has not been clearly demonstrated. Moreover, in some interventions an increase in total mortality has been reported. The objective of this meta-analysis was to determine the relationship between HDL cholesterol increase and non-cardiovascular mortality in randomised trials. Authors searched Medline up to December 2008. Four reviewers identified randomised trials in which, through different types of interventions, HDL cholesterol increase in the treatment group was >4% compared to control group, both groups reported separately non-cardiovascular mortality and the duration of the study was, at least, one year. Data of HDL cholesterol concentrations and deaths were collected as they appeared in the original studies. If necessary, reviewers calculated data by using trial information. Meta-regression analysis included 44 articles corresponding to 107 773 participants. Analysis showed an association between HDL cholesterol increase and non-cardiovascular mortality (p=0.023), however, the correlation disappeared when we excluded the ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerosis Events) trial from the analysis (p=0.972). Meta-regression analysis results suggest that increases in HDL cholesterol up to 40% are not associated with higher non-cardiovascular death. The increase in adverse events observed in some trials where HDL cholesterol was raised in large amounts could be related with the drug mechanisms more than the HDL cholesterol increase itself.

  6. Comparison of plastic, high-density carbon, and beryllium as NIF ablators

    Science.gov (United States)

    Kritcher, Andrea

    2017-10-01

    An effort is underway to compare the three principal ablators for National Ignition Facility (NIF) implosions: plastic (CH), High Density Carbon (HDC), and beryllium (Be). This presentation will summarize the comparison and discuss in more detail the issues pertaining to hohlraum performance and symmetry. Several aspects of the hohlraum design are affected by the ablator properties, as the ablator constrains the first shock and determines the overall pulse length. HDC targets can utilize shorter pulse lengths due to the thinner, higher density shell, and should be less susceptible to late time wall motion. However, HDC requires a larger picket energy to ensure adequate melt, leading to increased late time wall movement. Be is intermediate to CH and HDC in both these regards, and has more ablated material in the hohlraum. These tradeoffs as well as other design choices for currently fielded campaigns are assessed in this work. To assess consistently the radiation drive and symmetry, integrated postshot simulations of the hohlraum and capsule were done for each design using the same methodology. The simulation results are compared to experimental data. Using this post-shot model, we make a projection of the relative plausible performance that can be achieved, while maintaining adequate symmetry, using the full NIF laser, i.e. 1.8 MJ/500 TW Full NIF Equivalent (FNE). The hydrodynamic stability of the different ablators is also an important consideration and will be presented for the current platforms and projection to FNE. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  7. Dysfunctional high-density lipoproteins in children with chronic kidney disease.

    Science.gov (United States)

    Kaseda, Ryohei; Jabs, Kathy; Hunley, Tracy E; Jones, Deborah; Bian, Aihua; Allen, Ryan M; Vickers, Kasey C; Yancey, Patricia G; Linton, MacRae F; Fazio, Sergio; Kon, Valentina

    2015-02-01

    Our aim was to determine if chronic kidney disease (CKD) occurring in childhood impairs the normally vasoprotective functions of high-density lipoproteins (HDLs). HDLs were isolated from children with end-stage renal disease on dialysis (ESRD), children with moderate CKD and controls with normal kidney function. Macrophage response to HDLs was studied as expression of inflammatory markers (MCP-1, TNF-α, IL-1β) and chemotaxis. Human umbilical vein endothelial cells were used for expression of adhesion molecules (ICAM-1, VCAM-1, E-selectin) and adhesion. Cellular proliferation, apoptosis, and necrosis of endothelial cells were measured by MTS/PMS reagent-based assay, flow cytometry, and ELISA. Cholesterol efflux was assessed by gas chromatographic measurements of cholesterol in macrophages exposed to HDLs. Compared with HDL(Control), HDL(CKD) and HDL(ESRD) heightened the cytokine response and disrupted macrophage chemotaxis. HDL(Control) reduced endothelial expression of ICAM-1, VCAM-1, E-selectin, whereas HDL(CKD) and HDL(ESRD) were less effective and showed reduced capacity to protect endothelial cells against monocyte adhesion. Compared with a dramatically enhanced endothelial proliferation following injurious stimulus by HDL(Control), neither HDL(CKD) nor HDL(ESRD) caused proliferative effects. HDLs of all three groups were equally protective against apoptosis assessed by flow cytometry and cleaved caspase-3 activity. Compared to HDL(Control), HDL(CKD) and HDL(ESRD) trended toward reduced capacity as cholesterol acceptors. CKD in children impairs HDL function. Even in the absence of long-standing and concomitant risk factors, CKD alters specific HDL functions linked to control of inflammation and endothelial responses. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Vitamin D is associated with atheroprotective high-density lipoprotein profile in postmenopausal women

    Science.gov (United States)

    Kazlauskaite, Rasa; Powell, Lynda H.; Mandapakala, Chaitanya; Cursio, John F.; Avery, Elizabeth F.; Calvin, James

    2012-01-01

    BACKGROUND Low vitamin D has been associated with low levels of high-density lipoprotein (HDL) cholesterol, a marker of coronary risk. Whether atheroprotective HDL particle composition accounts for this association and whether fat affects this association is not known. OBJECTIVE To explore the association between HDL particle composition and 25-hydroxy vitamin D (25[OH]D) in post-menopausal women. METHODS Vitamin D levels and lipoprotein composition were assessed in fasting blood samples of apparently healthy women from a diverse Chicago community. Visceral (VAT) and subcutaneous (SAT) abdominal fat area were assessed using computed tomography. Total body fat mass was measured by dual-energy X-ray absorptiometry. RESULTS We enrolled 78 women (50% black; 50% white), age 48 to 64 years, all of whom were participants in a longitudinal study of fat patterning. They had a mean 25[OH]D of 31 ± 15 µg/L, HDL cholesterol 57 ± 11 mg/dL, and large HDL particle subclass 8.6 ± 3.4 µmol/L. In a multivariable-adjusted regression model, each 5 µg/L higher 25[OH]D predicted 0.57 µmol/L (95%CI 0.20–0.95) higher large HDL particles, independent of race, season, and total HDL particle concentration. This association was only partially confounded by total body fat mass (0.49, 95%CI 0.10–0.89), SAT (0.50, 95%CI 0.11–0.90), or VAT (0.37, 95%CI 0.01–0.74). Age did not significantly influence the strength of associations. CONCLUSIONS Higher 25[OH]D levels are associated with large HDL particles. This association is stronger than that of HDL cholesterol and only partially confounded by body fat. Theoretically, vitamin D may protect against cardiovascular risk by promoting formation of large HDL particles, affecting reverse cholesterol transport. PMID:21122638

  9. Guided wave propagation in a honeycomb composite sandwich structure in presence of a high density core.

    Science.gov (United States)

    Sikdar, Shirsendu; Banerjee, Sauvik

    2016-09-01

    A coordinated theoretical, numerical and experimental study is carried out in an effort to interpret the characteristics of propagating guided Lamb wave modes in presence of a high-density (HD) core region in a honeycomb composite sandwich structure (HCSS). Initially, a two-dimensional (2D) semi-analytical model based on the global matrix method is used to study the response and dispersion characteristics of the HCSS with a soft core. Due to the complex structural characteristics, the study of guided wave (GW) propagation in HCSS with HD-core region inherently poses many challenges. Therefore, a numerical simulation of GW propagation in the HCSS with and without the HD-core region is carried out, using surface-bonded piezoelectric wafer transducer (PWT) network. From the numerical results, it is observed that the presence of HD-core significantly decreases both the group velocity and the amplitude of the received GW signal. Laboratory experiments are then conducted in order to verify the theoretical and numerical results. A good agreement between the theoretical, numerical and experimental results is observed in all the cases studied. An extensive parametric study is also carried out for a range of HD-core sizes and densities in order to study the effect due to the change in size and density of the HD zone on the characteristics of propagating GW modes. It is found that the amplitudes and group velocities of the GW modes decrease with the increase in HD-core width and density. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Metabolism of triglyceride-rich nascent rat hepatic high density lipoproteins

    International Nuclear Information System (INIS)

    Winkler, K.E.; Marsh, J.B.

    1989-01-01

    Nascent high density lipoprotein (HDL) and nascent very low density lipoprotein (VLDL) were isolated from rat livers that had been perfused with [3H]glycerol to label the triglyceride. When injected into intact rats, the labeled HDL-triglyceride disappeared as rapidly as the VLDL-triglyceride, with only 10% of the injected label remaining in the plasma after 30 min. The protein moiety of nascent HDL was labeled with [35S]methionine in a similar fashion and the labeled nascent HDL was separated into nonretained (NR) and retained (R) fractions by heparin-Sepharose affinity chromatography. When injected into rats, 55% of the injected label in nascent fraction NR and 72% of that in nascent fraction R was recovered from plasma at 30 min, compared to only 10% of the triglyceride label from unfractionated nascent HDL, indicating dissociation of triglyceride and apolipoprotein clearance. The plasma decay curves for both triglyceride and protein were biexponential. By 5 min, 15% of the 35S label remaining in plasma represented apoE and apoC that had been transferred from nascent HDL fractions NR and R to the d less than 1.063 g/ml fraction of plasma. Plasma HDL was labeled in vivo with [35S]methionine, separated into fractions NR and R, and the clearance of the two plasma HDL fractions was compared with that of the corresponding nascent HDL fractions. Except for a faster rate of removal of the nascent HDL fractions during the first 5 min, the serum decay curves were very similar

  11. Birth control - slow release methods

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007555.htm Birth control - slow release methods To use the sharing features on this page, please enable JavaScript. Certain birth control methods contain man-made forms of hormones. ...

  12. High-density genetic mapping identifies the genetic basis of a natural colony morphology mutant in the root rot pathogen Armillaria ostoyae.

    Science.gov (United States)

    Heinzelmann, Renate; Croll, Daniel; Zoller, Stefan; Sipos, György; Münsterkötter, Martin; Güldener, Ulrich; Rigling, Daniel

    2017-11-01

    Filamentous fungi exhibit a broad spectrum of heritable growth patterns and morphological variations reflecting the adaptation of the different species to distinct ecological niches. But also within species, isolates show considerable variation in growth rates and other morphological characteristics. The genetic basis of this intraspecific variation in mycelial growth and morphology is currently poorly understood. By chance, a growth mutant in the root rot pathogen Armillaria ostoyae was discovered. The mutant phenotype was characterized by extremely compact and slow growth, as well as shorter aerial hyphae and hyphal compartments in comparison to the wildtype phenotype. Genetic analysis revealed that the abnormal phenotype is caused by a recessive mutation, which segregates asa single locus in sexual crosses. In order to identify the genetic basis of the mutant phenotype, we performed a quantitative trait locus (QTL) analysis. A mapping population of 198 haploid progeny was genotyped at 11,700 genome-wide single nucleotide polymorphisms (SNPs) making use of double digest restriction site associated DNA sequencing (ddRADseq). In accordance with the genetic analysis, a single significant QTL was identified for the abnormal growth phenotype. The QTL confidence interval spans a narrow, gene dense region of 87kb in the A. ostoyae genome which contains 37 genes. Overall, our study reports the first high-density genetic map for an Armillaria species and shows its successful application in forward genetics by resolving the genetic basis of a mutant phenotype with a severe defect in hyphal growth. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. STUDY OF EFFECTIVE TIME OF UNDILUTED FIXINGSOLUTIONS INLIGHTENING OF THE HIGH DENSITY PERIAPICAL RADIOGRAPHS

    Directory of Open Access Journals (Sweden)

    A ZAMANI NASER

    2003-12-01

    Full Text Available Introduction: Dental radiographs are occationally too dark because of different reasons such as over exposure, high concen-tration of developing solution and over development. Different chemicals are used to lighten these radiographs. In this research the undiluted fixed solution for the first time are tested and efficiency time of this solution in reducing the density of dark radiographs were evaluated. Method: Use of a dry mandible containing some teeth and 98 E speed periapical radiographs were prepared as foolow: A film wasexposed with 0.4 S... as positive control (ideal. 97 films were exposed with 1.8 S (dark and unreadable. Out of 97, one radiograph kept as positive control and remaining films prepared for study. All of radiographs developed and fixed with automatic processor in the same conditio. Out of 96 dark radiograph, 3 was used for pilot study and inserted in the undiluted fixing solution in different time. (2.5, 3 and 3.5 hrs. The result of pilot study showed that aii3 radiographs showed reductionin density and radiographs with her reduction time was closest to positive control for density and diognostic quality and radiograph with 2.5 hrs reduction time and 3.5 hre became darker and lighter as compared to positive control. The remaining 93 high density radiographs were divided into 3 groups, 31 in each group (group 1,2 and 3 first group 2.5 hrs, second 3 hrs and the third group 3.5 hrs were kept in undiluted fixed solution. for this, disposable glasses were used and in each glass a radiograph were inserted. The research time was spring and the temperature was about 2609 (without coolant. Evaluation of radiographs: For evaluation of radiographs 2 methods were used: First method used was: Densitometry: By this method the density of total lightened radiographs, positive control and negative control were determined. Another method was determined diagnostic quality of radiographs visually by radiologists, throng this way: Special

  14. High-density surface EMG maps from upper-arm and forearm muscles

    Directory of Open Access Journals (Sweden)

    Rojas-Martínez Monica

    2012-12-01

    Full Text Available Abstract Background sEMG signal has been widely used in different applications in kinesiology and rehabilitation as well as in the control of human-machine interfaces. In general, the signals are recorded with bipolar electrodes located in different muscles. However, such configuration may disregard some aspects of the spatial distribution of the potentials like location of innervation zones and the manifestation of inhomogineties in the control of the muscular fibers. On the other hand, the spatial distribution of motor unit action potentials has recently been assessed with activation maps obtained from High Density EMG signals (HD-EMG, these lasts recorded with arrays of closely spaced electrodes. The main objective of this work is to analyze patterns in the activation maps, associating them with four movement directions at the elbow joint and with different strengths of those tasks. Although the activation pattern can be assessed with bipolar electrodes, HD-EMG maps could enable the extraction of features that depend on the spatial distribution of the potentials and on the load-sharing between muscles, in order to have a better differentiation between tasks and effort levels. Methods An experimental protocol consisting of isometric contractions at three levels of effort during flexion, extension, supination and pronation at the elbow joint was designed and HD-EMG signals were recorded with 2D electrode arrays on different upper-limb muscles. Techniques for the identification and interpolation of artifacts are explained, as well as a method for the segmentation of the activation areas. In addition, variables related to the intensity and spatial distribution of the maps were obtained, as well as variables associated to signal power of traditional single bipolar recordings. Finally, statistical tests were applied in order to assess differences between information extracted from single bipolar signals or from HD-EMG maps and to analyze

  15. Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation.

    Science.gov (United States)

    Jiang, Suihe; Wang, Hui; Wu, Yuan; Liu, Xiongjun; Chen, Honghong; Yao, Mengji; Gault, Baptiste; Ponge, Dirk; Raabe, Dierk; Hirata, Akihiko; Chen, Mingwei; Wang, Yandong; Lu, Zhaoping

    2017-04-27

    Next-generation high-performance structural materials are required for lightweight design strategies and advanced energy applications. Maraging steels, combining a martensite matrix with nanoprecipitates, are a class of high-strength materials with the potential for matching these demands. Their outstanding strength originates from semi-coherent precipitates, which unavoidably exhibit a heterogeneous distribution that creates large coherency strains, which in turn may promote crack initiation under load. Here we report a counterintuitive strategy for the design of ultrastrong steel alloys by high-density nanoprecipitation with minimal lattice misfit. We found that these highly dispersed, fully coherent precipitates (that is, the crystal lattice of the precipitates is almost the same as that of the surrounding matrix), showing very low lattice misfit with the matrix and high anti-phase boundary energy, strengthen alloys without sacrificing ductility. Such low lattice misfit (0.03 ± 0.04 per cent) decreases the nucleation barrier for precipitation, thus enabling and stabilizing nanoprecipitates with an extremely high number density (more than 10 24 per cubic metre) and small size (about 2.7 ± 0.2 nanometres). The minimized elastic misfit strain around the particles does not contribute much to the dislocation interaction, which is typically needed for strength increase. Instead, our strengthening mechanism exploits the chemical ordering effect that creates backstresses (the forces opposing deformation) when precipitates are cut by dislocations. We create a class of steels, strengthened by Ni(Al,Fe) precipitates, with a strength of up to 2.2 gigapascals and good ductility (about 8.2 per cent). The chemical composition of the precipitates enables a substantial reduction in cost compared to conventional maraging steels owing to the replacement of the essential but high-cost alloying elements cobalt and titanium with inexpensive and lightweight aluminium

  16. Synthesis of manganese stearate for high density polyethylene (HDPE) and its biodegradation

    Energy Technology Data Exchange (ETDEWEB)

    Aras, Neny Rasnyanti M., E-mail: neny.rasnyanti@gmail.com; Arcana, I Made, E-mail: arcana@chem.itb.ac.id [Inorganic and Physical Chemistry Research Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132 (Indonesia)

    2015-09-30

    An oxidant additive is one type of additive used for oxo-biodegradable polymers. This additive was prepared by reaction multivalent transition metals and fatty acids to accelerate the degradation process of polymers by providing a thermal treatment or irradiation with light. This study focused on the synthesis of manganese stearate as an additive for application in High Density Polyethylene (HDPE), and the influence of manganese stearate on the characteristics of HDPE including their biodegradability. Manganese stearate was synthesized by the reaction of stearic acid with sodium hydroxide, and sodium stearate formed was reacted with manganese chloride tetrahydrate to form manganese stearate with a melting point of 100-110 °C. Based on the FTIR spectrum showed absorption peak at wave number around 1560 cm{sup −1} which is an asymmetric vibration of CO functional group that binds to the manganese. The films of oxo-biodegradable polymer were prepared by blending HDPE and manganese stearate additives at various concentrations with using the polymer melting method, followed heating at a temperature of 50°C and 70°C for 10 days. The characterizations of the oxo-biodegradable polymers were carried out by analysis the functional groups (FTIR and ATR),thermal properties (TGA), surface properties (SEM), as well as analysis of the biodegradability (the biodegradation test by using activated sludge, % weight loss). Based on COi indicate that the additive of manganese stearate is active in oxidizing polymer by heating treatment. Results of biodegradation by microorganisms from activated sludge showed that the percentage weight loss of polymers increase with the increasing incubation time and the concentration of manganese stearate in HDPE. Biodegradability of HDPE with the addition of manganese stearate and followed by heating at a higher temperature was better observed. The highest percentage weight loss was obtained at the polymer with concentration of 0.2% manganese

  17. Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction.

    Science.gov (United States)

    Gu, Xiaodong; Huang, Ying; Levison, Bruce S; Gerstenecker, Gary; DiDonato, Anthony J; Hazen, Leah B; Lee, Joonsue; Gogonea, Valentin; DiDonato, Joseph A; Hazen, Stanley L

    2016-01-22

    Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated protein with atherosclerosis-protective and systemic anti-oxidant functions. We recently showed that PON1, myeloperoxidase, and HDL bind to one another in vivo forming a functional ternary complex (Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., Zhang, R., Li, X. M., Didonato, A. J., Gogonea, V., Tang, W. H., et al. (2013) J. Clin. Invest. 123, 3815-3828). However, specific residues on PON1 involved in the HDL-PON1 interaction remain unclear. Unambiguous identification of protein residues involved in docking interactions to lipid surfaces poses considerable methodological challenges. Here we describe a new strategy that uses a novel synthetic photoactivatable and click chemistry-taggable phospholipid probe, which, when incorporated into HDL, was used to identify amino acid residues on PON1 that directly interact with the lipoprotein phospholipid surface. Several specific PON1 residues (Leu-9, Tyr-185, and Tyr-293) were identified through covalent cross-links with the lipid probes using affinity isolation coupled to liquid chromatography with on-line tandem mass spectrometry. Based upon the crystal structure for PON1, the identified residues are all localized in relatively close proximity on the surface of PON1, defining a domain that binds to the HDL lipid surface. Site-specific mutagenesis of the identified PON1 residues (Leu-9, Tyr-185, and Tyr-293), coupled with functional studies, reveals their importance in PON1 binding to HDL and both PON1 catalytic activity and stability. Specifically, the residues identified on PON1 provide important structural insights into the PON1-HDL interaction. More generally, the new photoactivatable and affinity-tagged lipid probe developed herein should prove to be a valuable tool for identifying contact sites supporting protein interactions with lipid interfaces such as found on cell membranes

  18. Glycation of human high density lipoprotein by methylglyoxal: effect on HDL-paraoxonase activity.

    Science.gov (United States)

    Bacchetti, Tiziana; Masciangelo, Simona; Armeni, Tatiana; Bicchiega, Virginia; Ferretti, Gianna

    2014-03-01

    Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases. Methylglyoxal exerts several biological activities. Among these it promotes advanced glycation end products (AGEs), which are crucial in pathogenesis of human disease. Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity. The aim of the study was to investigate the effect of in vitro MG-induced glycation on human high density lipoprotein (HDL) and on the activity of the enzyme paraoxonase-1 (PON1). HDL was incubated in the absence or in the presence of MG (0.2mmol/L and 1.0mmol/L) (MG-HDL) for different times (3, 6, 24h) at 37° C. We evaluated apoprotein compositional changes, in both control and MG treated HDL, using intrinsic fluorescence of tryptophan and monitoring the decrease of free amino groups. Furthermore we evaluated fluorescent advanced glycation end products (Ex=370nm, Em=440nm) and the activity of HDL-paraoxonase. We demonstrated that human HDL is susceptible to glycation by MG (0.2mmol/L and 1mmol/L). The decrease of free amino groups and of intrinsic fluorescence of tryptophan demonstrates HDL apoprotein modifications in HDL incubated with MG. The compositional changes are associated with a significant increase in fluorescent advanced glycation end products and with a significant decrease of paraoxonase-1 enzyme activity associated with the HDL surface. HDL-associated paraoxonase is responsible for the anti-inflammatory and anti-oxidative properties of HDL and detoxification against homocysteine-thiolactone. Therefore, modifications of apoprotein composition and the decrease of paraoxonase-1 activity in MG-treated HDL could affect the protective effect exerted by HDL against oxidative damage and could contribute to complications in patients affected by diseases

  19. Emergency rabies control in a community of two high-density hosts

    Directory of Open Access Journals (Sweden)

    Singer Alexander

    2012-06-01

    Full Text Available Abstract Background Rabies is a fatal viral disease that potentially can affect all mammals. Terrestrial rabies is not present in the United Kingdom and has been eliminated from Western Europe. Nevertheless the possibility remains that rabies could be introduced to England, where it would find two potentially suitable hosts, red foxes and badgers. With the aim to analyse the spread and emergency control of rabies in this two species host community, a simulation model was constructed. Different control strategies involving anti-rabies vaccination and population culling were developed, considering control application rates, spatial extent and timing. These strategies were evaluated for efficacy and feasibility to control rabies in hypothetical rural areas in the South of England immediately after a disease outbreak. Results The model confirmed that both fox and badger populations, separately, were competent hosts for the spread of rabies. Realistic vaccination levels were not sufficient to control rabies in high-density badger populations. The combined species community was a very strong rabies host. However, disease spread within species appeared to be more important than cross-species infection. Thus, the drivers of epidemiology depend on the potential of separate host species to sustain the disease. To control a rabies outbreak in the two species, both species had to be targeted. Realistic and robust control strategies involved vaccination of foxes and badgers, but also required badger culling. Although fox and badger populations in the UK are exceptionally dense, an outbreak of rabies can be controlled with a higher than 90% chance, if control response is quick and follows a strict regime. This requires surveillance and forceful and repeated control campaigns. In contrast, an uncontrolled rabies outbreak in the South of England would quickly develop into a strong epizootic involving tens of thousands of rabid foxes and badgers. Conclusions If

  20. Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol.

    Directory of Open Access Journals (Sweden)

    Dhanasekaran Bodhini

    Full Text Available Recent evidence suggests that lifestyle factors influence the association between the Melanocortin 4 receptor (MC4R and Transcription Factor 7-Like 2 (TCF7L2 gene variants and cardio-metabolic traits in several populations; however, the available research is limited among the Asian Indian population. Hence, the present study examined whether the association between the MC4R single nucleotide polymorphism (SNP (rs17782313 and two SNPs of the TCF7L2 gene (rs12255372 and rs7903146 and cardio-metabolic traits is modified by dietary factors and physical activity. This cross sectional study included a random sample of normal glucose tolerant (NGT (n = 821 and participants with type 2 diabetes (T2D (n = 861 recruited from the urban part of the Chennai Urban Rural Epidemiology Study (CURES. A validated food frequency questionnaire (FFQ was used for dietary assessment and self-reported physical activity measures were collected. The threshold for significance was set at P = 0.00023 based on Bonferroni correction for multiple testing [(0.05/210 (3 SNPs x 14 outcomes x 5 lifestyle factors]. After Bonferroni correction, there was a significant interaction between the TCF7L2 rs12255372 SNP and fat intake (g/day (Pinteraction = 0.0001 on high-density lipoprotein cholesterol (HDL-C, where the 'T' allele carriers in the lowest tertile of total fat intake had higher HDL-C (P = 0.008 and those in the highest tertile (P = 0.017 had lower HDL-C compared to the GG homozygotes. In a secondary analysis of SNPs with the subtypes of fat, there was also a significant interaction between the SNP rs12255372 and polyunsaturated fatty acids (PUFA, g/day (Pinteraction<0.0001 on HDL-C, where the minor allele carriers had higher HDL-C in the lowest PUFA tertile (P = 0.024 and those in the highest PUFA tertile had lower HDL-C (P = 0.028 than GG homozygotes. In addition, a significant interaction was also seen between TCF7L2 SNP rs12255372 and fibre intake (g/day on HDL

  1. Growth Performance of Catfish (Clarias Gariepinus Burchell, 1822) Cultured in High Density on the Biofloc System

    Science.gov (United States)

    Basuki, Fajar; Yuniarti, Tristiana; Harwanto, Dicky; Susilowati, Titik

    2018-02-01

    Start your The fish farmers and researchers have made efforts to increase catfish production through high levels of dispersal and application of biofloc systems. This system, in addition to increase production, can also predict when the harvest is done, control the quality of water causing death so that the Survival Rate (SR) is high. The purpose of this study is to determine the growth performance and predict the harvest weight and catfish survival rate (SR) that are cultured with different high density on the biofloc system. The research method used is experimental with test fish in the form of catfish seeds weighing of 8 ± 0.2 gram/fish with each density as treatment: P1. Density of 1,100 fish/m3; P2. Density of 1,200 fish/m3 and P3. Density of 1,300 fish/m3. Pond: The pond used is made of 3m in diameter of tarpaulin, equipped with a 6mm diameter of iron frame. Total volume of water in each pond is 3 m3. Catfish seeds have been adapted and put into the pond at random with the length of cultivation period is 4 weeks. Growth performance analysis uses the SPSS regression statistic series 20. The research results showed that the growth performance for 4 weeks showed that P1 generates the regression equation Y1 = 6.46 +7.81 X with r2 = 0.971 means that if the harvest is done at week 12th then the weight of catfish has reached 100 grams; P2 generates the regression equation Y2 = 6.53 + 6.0 X den r2 = 0.969 means if the harvest is done at week 12th then the weight of new catfish has reached 78.53 grams and P3 generates the regression equation Y3 = 6.71 + 5.94 X with r2 = 0.976 means if harvest is done on week 12th then the weight of new catfish has reached 77.99 grams. Survival rate at P1 = 97.73%; P2 = 95.91% and P3 = 94.55% while the oxygenated water quality is more than 3.5 ppm; pH ranged from 6.7-7 and ammonia content at week 3 is P1 = 0.04 mg/l; P2 = 0.13 mg/l and P3 = 0.27 mg/l.

  2. Repairability of CAD/CAM high-density PMMA- and composite-based polymers.

    Science.gov (United States)

    Wiegand, Annette; Stucki, Lukas; Hoffmann, Robin; Attin, Thomas; Stawarczyk, Bogna

    2015-11-01

    The study aimed to analyse the shear bond strength of computer-aided design and computer-aided manufacturing (CAD/CAM) polymethyl methacrylate (PMMA)- and composite-based polymer materials repaired with a conventional methacrylate-based composite after different surface pretreatments. Each 48 specimens was prepared from six different CAD/CAM polymer materials (Ambarino high-class, artBloc Temp, CAD-Temp, Lava Ultimate, Telio CAD, Everest C-Temp) and a conventional dimethacrylate-based composite (Filtek Supreme XTE, control) and aged by thermal cycling (5000 cycles, 5-55 °C). The surfaces were left untreated or were pretreated by mechanical roughening, aluminium oxide air abrasion or silica coating/silanization (each subgroup n = 12). The surfaces were further conditioned with an etch&rinse adhesive (OptiBond FL) before the repair composite (Filtek Supreme XTE) was adhered to the surface. After further thermal cycling, shear bond strength was tested, and failure modes were assessed. Shear bond strength was statistically analysed by two- and one-way ANOVAs and Weibull statistics, failure mode by chi(2) test (p ≤ 0.05). Shear bond strength was highest for silica coating/silanization > aluminium oxide air abrasion = mechanical roughening > no surface pretreatment. Independently of the repair pretreatment, highest bond strength values were observed in the control group and for the composite-based Everest C-Temp and Ambarino high-class, while PMMA-based materials (artBloc Temp, CAD-Temp and Telio CAD) presented significantly lowest values. For all materials, repair without any surface pretreatment resulted in adhesive failures only, which mostly were reduced when surface pretreatment was performed. Repair of CAD/CAM high-density polymers requires surface pretreatment prior to adhesive and composite application. However, four out of six of the tested CAD/CAM materials did not achieve the repair bond strength of a conventional dimethacrylate

  3. Thermal and physico-mechanical stability of recycled high density polyethylene reinforced with oil palm fibres

    Directory of Open Access Journals (Sweden)

    R.O. Medupin

    2017-12-01

    Full Text Available The impressive physical and mechanical properties achievable with organic fillers make them a good choice for polymer composite reinforcement. In this study, oil palm fibres (OPF, often hardly thought of as having any reasonable economic value in developing economy was used as reinforcing fillers in recycled high density polyethylene (rHDPE. Thermal behaviour, physical and mechanical stability of rHDPE filled with OPF have been studied. Fourier Transform Infrared Spectroscopy (FTIR results present band spectra characteristic of OH stretching vibration in the cellulose of the fibre material. The absorption bands of the spectra are attributed to the presence of stretching vibration of CO group mostly found in the form of hemicelluloses and lignin structure in the fibre. Upon examination of the test specimens produced through compression moulding technique, it was found that the addition of OPF (filler into rHDPE (matrix increased the composites’ water absorption rate linearly for the first 16 days of exposure to the water environment. Stability was achieved for all the materials after this period. Thermal studies of the various compositions (OPF/rHDPE: 5/95, 10/90, 15/85, 20/80 and 25/75 using derivative thermogravimetric analysis (DTGA showed two main degradation peaks at 490 °C and 380 °C. The mechanical study revealed that the composite with 20 wt% filler contents was the most eco-friendly and had the best mechanical properties while that with 25 wt% was the most thermally stable. This material was thermally stable up to approximately 330 °C. Microstructure examination of the different components of the composites further explains the reason for good physical and mechanical strength of the sample with 20 wt% filler. It can, therefore, be inferred from the results of the various analyses conducted that OPF is a good reinforcing phase for rHDPE and a potential material for construction and automotive industries.

  4. Extensive Sampling of Forest Carbon using High Density Power Line Lidar

    Science.gov (United States)

    Hampton, H. M.; Chen, Q.; Dye, D. G.; Hungate, B. A.

    2013-12-01

    Estimating carbon sequestration and greenhouse gas emissions from forest management, natural processes, and disturbance is of growing interest for mitigating global warming. Ponderosa pine is common at mid-elevations throughout the western United States and is a dominant tree species in southwestern forests. Existing unmanaged "relict" sites and stand reconstructions of southwestern ponderosa pine forests from before European settlement (late 1800s) provide evidence of forests of larger trees of lower density and less vulnerability to severe fires than today's typical conditions of high densities of small trees that have resulted from a century of fire suppression. Forest treatments to improve forest health in the region include tree cutting focused on small-diameter trees (thinning), low-intensity prescribed burning, and monitoring rather than suppressing wildfires. Stimulated by several uncharacteristically-intense fires in the last decade, a collaborative process found strong stakeholder agreement to accelerate forest treatments to reduce fire risk and restore ecological conditions. Land use planning to ramp up management is underway and could benefit from quick and inexpensive techniques to inventory tree-level carbon because existing inventory data are not adequate to capture the range of forest structural conditions. Our approach overcomes these shortcomings by employing recent breakthroughs in estimating aboveground biomass from high resolution light detection and ranging (lidar) remote sensing. Lidar is an active remote sensing technique, analogous to radar, which measures the time required for a transmitted pulse of laser light to return to the sensor after reflection from a target. Lidar data can capture 3-dimensional forest structure with greater detail and broader spatial coverage than is feasible with conventional field measurements. We developed a novel methodology for extensive sampling and field validation of forest carbon, applicable to managed and

  5. Non-high-density lipoprotein cholesterol calculation and goal awareness among physicians-in-training.

    Science.gov (United States)

    Negi, Smita I; Steinberg, Lynne; Polsani, Venkateshwar R; Gowani, Saqib A; Nambi, Vijay; Kumar, Varinder; Marinescu, Victor; Jones, Peter H; Petersen, Laura A; Ballantyne, Christie M; Virani, Salim S

    2012-01-01

    Non-high density lipoprotein cholesterol (non-HDL-C) goal attainment per Adult Treatment Panel III (ATP III) guidelines remains low. To understand gaps in knowledge and practices of physicians-in-training (internal medicine, family medicine, cardiology, endocrinology) towards non-HDL-C. A survey based on a conceptual model to assess the trainee's knowledge, attitudes, and practice regarding non-HDL-C was developed and administered to physicians-in-training (n = 655) at 26 training programs in the United States. Responses of those in internal medicine and family medicine (residents-in-training; n = 418) were compared with those in cardiology and endocrinology (fellows-in-training; n = 124). Response rate was 83.7%. Fifty-three percent of residents and 31% of fellows-in-training had not read the ATP III guidelines (P training could not calculate non-HDL-C from a standard lipid panel (P = .7). Sixty-seven percent of the residents and 52% of fellows were not aware of treatment goals for non-HDL-C (P = .004 for comparison between residents and fellows). Both residents and fellows reported infrequent calculation of non-HDL-C levels in patients with elevated triglycerides (≥200 mg/dL; 32.5% vs 35.4%, respectively, P = .6). Lack of familiarity with ATP III guidelines, lack of knowledge regarding importance of non-HDL-C, lack of institutional mandate to calculate non-HDL-C, and lack of emphasis on non-HDL-C by teaching staff were reported as barriers to non-HDL-C use in routine clinical practice. At least one-third of physicians-in-training could not calculate non-HDL-C from a standard lipid panel, and a large number were not aware of ATP III treatment goals pertaining to non-HDL-C. This area represents one for improvement if non-HDL-C is to be retained as a treatment target in the forthcoming ATP-IV guidelines. Published by Elsevier Inc.

  6. Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG.

    Science.gov (United States)

    Hedrich, T; Pellegrino, G; Kobayashi, E; Lina, J M; Grova, C

    2017-08-15

    The present study aims at evaluating and comparing electrical and magnetic distributed source imaging methods applied to high-density Electroencephalography (hdEEG) and Magnetoencephalography (MEG) data. We used resolution matrices to characterize spatial resolution properties of Minimum Norm Estimate (MNE), dynamic Statistical Parametric Mapping (dSPM), standardized Low-Resolution Electromagnetic Tomography (sLORETA) and coherent Maximum Entropy on the Mean (cMEM, an entropy-based technique). The resolution matrix provides information of the Point Spread Functions (PSF) and of the Crosstalk functions (CT), this latter being also called source leakage, as it reflects the influence of a source on its neighbors. The spatial resolution of the inverse operators was first evaluated theoretically and then with real data acquired using electrical median nerve stimulation on five healthy participants. We evaluated the Dipole Localization Error (DLE) and the Spatial Dispersion (SD) of each PSF and CT map. cMEM showed the smallest spatial spread (SD) for both PSF and CT maps, whereas localization errors (DLE) were similar for all methods. Whereas cMEM SD values were lower in MEG compared to hdEEG, the other methods slightly favored hdEEG over MEG. In real data, cMEM provided similar localization error and significantly less spatial spread than other methods for both MEG and hdEEG. Whereas both MEG and hdEEG provided very accurate localizations, all the source imaging methods actually performed better in MEG compared to hdEEG according to all evaluation metrics, probably due to the higher signal-to-noise ratio of the data in MEG. Our overall results show that all investigated methods provide similar localization errors, suggesting very accurate localization for both MEG and hdEEG when similar number of sensors are considered for both modalities. Intrinsic properties of source imaging methods as well as their behavior for well-controlled tasks, suggest an overall better

  7. Propagation of sound wave in high density deuterium at high temperatures

    International Nuclear Information System (INIS)

    Inoue, Kazuko; Ariyasu, Tomio

    1986-01-01

    The velocity and the attenuation constant of sound wave have been calculated for high density (10 24 ∼ 10 27 /cm 3 ) deuterium at high temperatures (10 -1 ∼ 10 4 eV). This calculation was made to understand the fuel properties in inertial confinement fusion and to obtain the basic data for pellet design. The isentropic sound wave which propagates in deuterium in plasma state at temperature T i = T e , is dealt with. The velocity is derived using the modulus of bulk elasticity of the whole system and the modulus of shear elasticity due to ion-ion interaction. For the calculation of attenuation constant, the bulk and shear viscosity due to ion-ion interaction, the shear viscosity of free electron gas, and the thermal conductivity due to free electrons are considered. The condition of frequency for the existence of such isentropic sound wave is discussed. The possibility of penetration into the fuel pellet in inertial confinement fusion is also discussed. The followings have been found: (1) The sound velocity is determined mainly from the bulk elasticity. The contribution of the shear elasticity is small. The velocity ranges from 2.8 x 10 6 to 1.5 x 10 8 cm/s in the above mentioned temperature and density regions. (2) The coefficient of attenuation constant with respect to ω 2 /2ρu 3 plotted versus temperature with the parameter of density shows a minimum. At temperatures below this minimum, the attenuation comes mainly from the bulk viscosity due to ion-ion interaction and the shear viscosity due to free electron gas. At temperatures above this minimum, the sound is attenuated mainly by the thermal conductivity due to electrons. (3) The condition for the existence of such adiabatic sound wave, is satisfied with the frequency less than 10 10 Hz. But, as for the pellet design, the wave length of sound with frequency less than 10 10 Hz is longer than the diameter of pellet when compressed highly. (author)

  8. Comparison of decoding resolution of standard and high-density electrocorticogram electrodes

    Science.gov (United States)

    Wang, Po T.; King, Christine E.; McCrimmon, Colin M.; Lin, Jack J.; Sazgar, Mona; Hsu, Frank P. K.; Shaw, Susan J.; Millet, David E.; Chui, Luis A.; Liu, Charles Y.; Do, An H.; Nenadic, Zoran

    2016-04-01

    Objective. Electrocorticography (ECoG)-based brain-computer interface (BCI) is a promising platform for controlling arm prostheses. To restore functional independence, a BCI must be able to control arm prostheses along at least six degrees-of-freedoms (DOFs). Prior studies suggest that standard ECoG grids may be insufficient to decode multi-DOF arm movements. This study compared the ability of standard and high-density (HD) ECoG grids to decode the presence/absence of six elementary arm movements and the type of movement performed. Approach. Three subjects implanted with standard grids (4 mm diameter, 10 mm spacing) and three with HD grids (2 mm diameter, 4 mm spacing) had ECoG signals recorded while performing the following movements: (1) pincer grasp/release, (2) wrist flexion/extension, (3) pronation/supination, (4) elbow flexion/extension, (5) shoulder internal/external rotation, and (6) shoulder forward flexion/extension. Data from the primary motor cortex were used to train a state decoder to detect the presence/absence of movement, and a six-class decoder to distinguish between these movements. Main results. The average performances of the state decoders trained on HD ECoG data were superior (p = 3.05 × 10-5) to those of their standard grid counterparts across all combinations of the μ, β, low-γ, and high-γ frequency bands. The average best decoding error for HD grids was 2.6%, compared to 8.5% of standard grids (chance 50%). The movement decoders trained on HD ECoG data were superior (p = 3.05 × 10-5) to those based on standard ECoG across all band combinations. The average best decoding errors of 11.9% and 33.1% were obtained for HD and standard grids, respectively (chance error 83.3%). These improvements can be attributed to higher electrode density and signal quality of HD grids. Significance. Commonly used ECoG grids are inadequate for multi-DOF BCI arm prostheses. The performance gains by HD grids may eventually lead to independence-restoring BCI

  9. High density trans-admittance mammography development and preliminary phantom tests

    Directory of Open Access Journals (Sweden)

    Zhao Mingkang

    2012-09-01

    Full Text Available Abstract Background Malignant breast tumor tissue has a significantly different electrical impedance spectrum than surrounding normal tissues. This has led to the development of impedance imaging as a supplementary or alternative method to X-ray mammography for screening and assessment of breast cancers. However low spatial resolution and poor signal to noise ratio has limited the clinical application. Methods In order to improve spatial resolution we developed a trans-admittance mammography (TAM system including an array of 60×60 current sensing electrodes. We adopted a similar setup to X-ray mammography where the breast is situated between two holding plates. The top plate is a large solid metal electrode for applying a sinusoidal voltage over a range of frequencies from 50 Hz to 500 kHz. The bottom plate has 3600 current sensing electrodes that are kept at the ground potential. Currents are generated from the top voltage-applying electrode and spread throughout the breast, entering the TAM system through the array of current sensing electrodes on the bottom plate. The TAM system measures the exit currents through 6 switching modules connected to 600 electrodes each. Each switching module is connected to 12 ammeter channels which are switched sequentially to 50 of the 600 electrodes each measurement time. Each ammeter channel is comprised of a current-to-voltage converter, a gain amplifier, filters, an analog to digital converter, and a digital phase sensitive demodulator. Results We found an average noise level of 38 nA, amplitude stability of less than 0.2%, crosstalk of better than -60 dB and 70 dB signal to noise ratio over all channels and operating frequencies. Images were obtained in time difference and frequency difference modes in a saline phantom. Conclusion We describe the design, construction, and calibration of a high density TAM system in detail. Successful high resolution time and frequency difference images showed regions of

  10. The Potential of/for 'Slow': Slow Tourists and Slow Destinations

    Directory of Open Access Journals (Sweden)

    J. Guiver

    2016-05-01

    Full Text Available Slow tourism practices are nothing new; in fact, they were once the norm and still are for millions of people whose annual holiday is spent camping, staying in caravans, rented accommodation, with friends and relations or perhaps in a second home, who immerse themselves in their holiday environment, eat local food, drink local wine and walk or cycle around the area. So why a special edition about slow tourism? Like many aspects of life once considered normal (such as organic farming or free-range eggs, the emergence of new practices has highlighted differences and prompted a re-evaluation of once accepted practices and values. In this way, the concept of ‘slow tourism’ has recently appeared as a type of tourism that contrasts with many contemporary mainstream tourism practices. It has also been associated with similar trends already ‘branded’ slow: slow food and cittaslow (slow towns and concepts such as mindfulness, savouring and well-being.

  11. Abnormal pain processing in chronic tension-type headache: a high-density EEG brain mapping study

    DEFF Research Database (Denmark)

    Buchgreitz, L.; Egsgaard, L.L.; Jensen, R.

    2008-01-01

    Central sensitization caused by prolonged nociceptive input from muscles is considered to play an important role for chronification of tension-type headache. In the present study we used a new high-density EEG brain mapping technique to investigate spatiotemporal aspects of brain activity...

  12. Carotid intima media thickness is related positively to plasma pre beta-high density lipoproteins in non-diabetic subjects

    NARCIS (Netherlands)

    de Vries, Rindert; Perton, Frank G.; van Tol, Arie; Dullaart, Robin P. F.

    2012-01-01

    Background: Lipid-poor or lipid-free high density lipoprotein (HDL) particles, designated pre beta-HDL, stimulate removal of cell-derived cholesterol to the extracellular compartment, which is an initial step in the reverse cholesterol transport pathway. Pre beta-HDL levels may be elevated in

  13. The neutron/proton ratio of squeezed-out nucleons and the high density behavior of the nuclear symmetry energy

    International Nuclear Information System (INIS)

    Yong Gaochan; Li Baoan; Chen Liewen

    2007-01-01

    Within a transport model it is shown that the neutron/proton ratio of squeezed-out nucleons perpendicular to the reaction plane, especially at high transverse momenta, in heavy-ion reactions induced by high energy neutron-rich nuclei can be a useful tool for studying the high density behavior of the nuclear symmetry energy

  14. Neutron and photon scattering properties of high density concretes used in radiation therapy facilities: A Monte Carlo study

    Science.gov (United States)

    Mesbahi, Asghar; Khaldari, Rezvan

    2017-09-01

    In the current study the neutron and photon scattering properties of some newly developed high density concretes (HDCs) were calculated by using MCNPX Monte Carlo code. Five high-density concretes including Steel-Magnetite, Barite, Datolite-Galena, Ilmenite-ilmenite, Magnetite-Lead with the densities ranging from 5.11 g/cm3 and ordinary concrete with density of 2.3 g/cm3 were studied in our simulations. The photon beam spectra of 4 and 18 MV from Varian linac and neutron spectra of clinical 18 MeV photon beam was used for calculations. The fluence of scattered photon and neutron from all studied concretes was calculated in different angles. Overall, the ordinary concrete showed higher scattered photons and Datolite-Galena concrete (4.42 g/cm3) had the lowest scattered photons among all studied concretes. For neutron scattering, fluence at the angle of 180 was higher relative to other angles while for photons scattering fluence was maximum at 90 degree. The scattering fluence for photons and neutrons was dependent on the angle and composition of concrete. The results showed that the fluence of scattered photons and neutrons changes with the composition of high density concrete. Also, for high density concretes, the variation of scattered fluence with angle was very pronounced for neutrons but it changed slightly for photons. The results can be used for design of radiation therapy bunkers.

  15. Genomotyping of Pseudomonas putida strains using P. putida KT2440-based high-density DNA microarrays: Implications for transcriptomics studies

    NARCIS (Netherlands)

    Ballerstedt, H.; Volkers, R.J.M.; Mars, A.E.; Hallsworth, J.E.; Santos, V.A.M.D.; Puchalka, J.; Duuren, J. van; Eggink, G.; Timmis, K.N.; Bont, J.A.M. de; Wery, J.

    2007-01-01

    Pseudomonas putida KT2440 is the only fully sequenced P. putida strain. Thus, for transcriptomics and proteomics studies with other P. putida strains, the P. putida KT2440 genomic database serves as standard reference. The utility of KT2440 whole-genome, high-density oligonucleotide microarrays for

  16. Modulation of low-density lipoprotein-induced inhibition of intercellular communication by antioxidants and high-density lipoproteins

    NARCIS (Netherlands)

    Zwijsen, R. M.; de Haan, L. H.; Kuivenhoven, J. A.; Nusselder, I. C.

    1991-01-01

    In order to study the capacity of antioxidants and high-density lipoproteins (HDL) to modulate the effects of low-density lipoprotein (LDL) on intercellular communication, arterial smooth muscle cells and a dye transfer method were used. LDL, in contrast to HDL, inhibited the communication between

  17. Modulation of low-density lipoprotein-induced inhibition of intercellular communication by antioxidants and high-density lipoproteins

    NARCIS (Netherlands)

    Zwijsen, R M; de Haan, L. H. J.; Kuivenhoven, J A; Nusselder, I C

    In order to study the capacity of antioxidants and high-density lipoproteins (HDL) to modulate the effects of low-density lipoprotein (LDL) on intercellular communication, arterial smooth muscle cells and a dye transfer method were used. LDL, in contrast to HDL, inhibited the communication between

  18. Small-Scale Production of High-Density Dry Ice: A Variant Combination of Two Classic Demonstrations

    Science.gov (United States)

    Flowers, Paul A.

    2009-01-01

    Easily recoverable, thumb-sized pieces of high-density dry ice are conveniently produced by deposition of carbon dioxide within a test tube submerged in liquid nitrogen. A carbon dioxide-filled balloon sealed over the mouth of the test tube serves as a gas reservoir, and further permits a dramatic demonstration of both the gas-to-solid phase…

  19. Unidirectional threshold switching in Ag/Si-based electrochemical metallization cells for high-density bipolar RRAM applications

    Science.gov (United States)

    Wang, Chao; Song, Bing; Li, Qingjiang; Zeng, Zhongming

    2018-03-01

    We herein present a novel unidirectional threshold selector for cross-point bipolar RRAM array. The proposed Ag/amorphous Si based threshold selector showed excellent threshold characteristics in positive field, such as high selectivity ( 105), steep slope (experiments showed that the undesired sneak was significantly suppressed, indicating its potentiality for high-density integrated nonvolatile memory applications.

  20. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents

    DEFF Research Database (Denmark)

    Khetarpal, Sumeet A; Schjoldager, Katrine T; Christoffersen, Christina

    2016-01-01

    Human genetics studies have implicated GALNT2, encoding GalNAc-T2, as a regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, but the mechanisms relating GALNT2 to HDL-C remain unclear. We investigated the impact of homozygous GALNT2 deficiency on HDL-C in humans and mammalian mod...