Sample records for previously controversial experimental

  1. The Animal Experimentation Controversy: Ethical Views of Prospective Teachers (United States)

    de Villiers, Rian


    Vivisection (live animal experimentation) is a controversial issue for many people. The purpose of this case study is to examine the attitudes of prospective teachers toward vivisection in education and research, to determine if gender has an influence on these attitudes, and to discuss the implications of these attitudes with regard to teaching…

  2. Experimental, controversial, and futuristic treatments for chronic tinnitus. (United States)

    Folmer, Robert L; Theodoroff, Sarah M; Martin, William Hal; Shi, Yongbing


    Because chronic tinnitus is a condition that negatively impacts the quality of life of millions of people worldwide, a safe and effective treatment for tinnitus has been sought for millennia. However, effective treatments for tinnitus are greatly outnumbered by ineffective strategies, medications, devices, and surgeries that continue to be developed and promoted for the condition. This article describes and critiques experimental, controversial, and potential treatments for chronic tinnitus. The purpose of this review is to provide information that should help patients and clinicians to select tinnitus treatment and management strategies most likely to be effective for each set of symptoms and circumstances. PubMed and MEDLINE databases (National Center for Biotechnology Information, U.S. National Library of Medicine) were searched for the term tinnitus in articles published from 1940 to 2012. Other historical documents and publications were also reviewed as needed for particular topics. Studies included in this review were selected to represent a sampling of treatment methodologies that have been used for tinnitus. Due to the heterogeneity of the studies reviewed, it was not appropriate to perform a meta-analysis. A selective review of the literature was conducted to summarize and critique published research results. Most invasive treatments for tinnitus should be avoided because (1) at best, there is scant evidence that any of these treatments is effective, and (2) the risk to patients for most invasive procedures is much greater than the risk posed by the tinnitus perception. Effective and noninvasive treatments for tinnitus include acoustic therapy (which includes hearing aids and other types of environmental sound enrichment); cognitive-behavioral therapy; psychological counseling; hypnosis; biofeedback; and relaxation training. Over-the-counter or prescription medications may be used as needed to facilitate sleep and to reduce anxiety, depression, or

  3. Using a Discussion about Scientific Controversy to Teach Central Concepts in Experimental Design (United States)

    Bennett, Kimberley Ann


    Students may need explicit training in informal statistical reasoning in order to design experiments or use formal statistical tests effectively. By using scientific scandals and media misinterpretation, we can explore the need for good experimental design in an informal way. This article describes the use of a paper that reviews the measles mumps…

  4. Life-history traits in an evergreen Mediterranean oak respond differentially to previous experimental environments

    Directory of Open Access Journals (Sweden)

    J. M. Rey Benayas


    Full Text Available Living organisms respond both to current and previous environments, which can have important consequences on population dynamics. However, there is little experimental evidence based on long-term field studies of the effects of previous environments on the performance of individuals. We tested the hypothesis that trees that establish under different environmental conditions perform differently under similar post-establishment conditions. We used the slow-growing, evergreen Mediterranean oak Quercus ilex subsp. rotundifolia as target species. We analyzed the effects of previous environments, competition effects and tradeoffs among life-history traits (survival, growth, and reproduction. We enhanced seedling establishment for three years by reducing abiotic environmental harshness by means of summer irrigation and artificial shading in 12 experimental plots, while four plots remained as controls. Then these treatments were interrupted for ten years. Seedlings under ameliorated environmental conditions survived and grew faster during early establishment. During the post-management period, previous treatments 1 did not have any effect on survival, 2 experienced a slower above-ground growth, 3 decreased root biomass as indicated from reflectivity of Ground Penetration Radar, 4 increased acorn production mostly through a greater canopy volume and 5 increased acorn production effort. The trees exhibited a combination of effects related to acclimation for coping with abiotic stress and effects of intra-specific competition. In accordance with our hypothesis, tree performance overall depended on previous environmental conditions, and the response was different for different life-history traits. We recommend early management because it increased plot cover, shortened the time to attain sexual maturity and increased the amount of acorn production. Plots such as those assessed in this study may act as sources of propagules in deforested

  5. Explaining own and others' behavior in a controversial issue: animal experimentation. (United States)

    Kemdal, A B; Montgomery, H


    The authors investigated how 2 groups with different attitudes toward animal experimentation-researchers who conducted animal experiments and members of animal welfare organizations who protested against animal experiments--made attributions for the behavior of the opposing group. The 2 groups showed an actor--observer effect, mentioning more internal causes for the opponents' behavior and more external causes for their own behavior. Both groups were able to take the other's perspective, resulting in a reversed actor-observer effect. The less involved participants followed the pattern of ratings of the group whose attitudes corresponded to their own. In particular, the participants with a negative attitude toward animal experimentation rated researchers' behavior as more internally caused than did those with a positive attitude. The results illustrated how the participants formed and defended attitudes in a social context.

  6. Computational Controversy

    NARCIS (Netherlands)

    Timmermans, Benjamin; Kuhn, Tobias; Beelen, Kaspar; Aroyo, Lora


    Climate change, vaccination, abortion, Trump: Many topics are surrounded by fierce controversies. The nature of such heated debates and their elements have been studied extensively in the social science literature. More recently, various computational approaches to controversy analysis have

  7. Experimental dengue virus challenge of human subjects previously vaccinated with live attenuated tetravalent dengue vaccines. (United States)

    Sun, Wellington; Eckels, Kenneth H; Putnak, J Robert; Lyons, Arthur G; Thomas, Stephen J; Vaughn, David W; Gibbons, Robert V; Fernandez, Stefan; Gunther, Vicky J; Mammen, Mammen P; Statler, John D; Innis, Bruce L


    Protection against dengue requires immunity against all 4 serotypes of dengue virus (DENV). Experimental challenge may be useful in evaluating vaccine-induced immunity. Ten subjects previously vaccinated with a live attenuated tetravalent dengue vaccine (TDV) and 4 DENV-naive control subjects were challenged by subcutaneous inoculation of either 10(3) plaque-forming units (PFU) of DENV-1 or 10(5) PFU of DENV-3. Two additional subjects who did not develop DENV-3 neutralizing antibody (NAb) from TDV were revaccinated with 10(4) PFU of live attenuated DENV-3 vaccine to evaluate memory response. All 5 TDV recipients were protected against DENV-1 challenge. Of the 5 TDV recipients challenged with DENV-3, 2 were protected. All DENV-3-challenge subjects who developed viremia also developed elevated liver enzyme levels, and 2 had values that were >10 times greater than normal. Of the 2 subjects revaccinated with DENV-3 vaccine, 1 showed a secondary response to DENV-2, while neither showed such response to DENV-3. All 4 control subjects developed dengue fever from challenge. Protection was associated with presence of NAb, although 1 subject was protected despite a lack of measurable NAb at the time of DENV-1 challenge. Vaccination with TDV induced variable protection against subcutaneous challenge. DENV-3 experimental challenge was associated with transient but marked elevations of transaminases.

  8. Haplotype association between haptoglobin (Hp2 and Hp promoter SNP (A-61C may explain previous controversy of haptoglobin and malaria protection.

    Directory of Open Access Journals (Sweden)

    Sharon E Cox


    Full Text Available Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria susceptibility.Risk of a clinical malarial episode over the course of a malarial transmission season was assessed using active surveillance in a cohort of Gambian children aged 10-72 months. We report for the first time that the major haplotype for the A-61C mutant allele in the promoter of haptoglobin (Hp-an acute phase protein that clears haemoglobin released from haemolysis of red cells-is associated with protection from malarial infection in older children, (children aged >or=36 months, >500 parasites/ul and temperature >37.5 degrees C; OR = 0.42; [95% CI 0.24-0.73] p = 0.002 (lr test for interaction, or=36 months, p = 0.014. Protection was also observed using two other definitions, including temperature >37.5 degrees C, dipstick positive, plus clinical judgement of malaria blinded to dipstick result (all ages, OR = 0.48, [95% CI 0.30-0.78] p = 0.003; >or=36 months, OR = 0.31, [95% CI 0.15-0.62] p = 0.001. A similar level of protection was observed for the known protective genetic variant, sickle cell trait (HbAS.We propose that previous conflicting results between Hp phenotypes/genotypes and malaria susceptibility may be explained by differing prevalence of the A-61C SNP in the populations studied, which we found to be highly associated with the Hp2 allele. We report the -61C allele to be associated with decreased Hp protein levels (independent of Hp phenotype, confirming in vitro studies. Decreased Hp expression may lead to increased oxidant stress and increased red cell turnover, and facilitate the development of acquired immunity, similar to

  9. Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: experimental evidence to resolve some controversies

    NARCIS (Netherlands)

    Coronel, Ruben; de Bakker, Jacques M. T.; Wilms-Schopman, Francien J. G.; Opthof, Tobias; Linnenbank, André C.; Belterman, Charly N.; Janse, Michiel J.


    BACKGROUND: Activation recovery intervals (ARIs) and monophasic action potential (MAP) duration are used as measures of action potential duration in beating hearts. However, controversies exist concerning the correct way to record MAPs or calculate ARIs. We have addressed these issues

  10. Plutonium controversy

    Energy Technology Data Exchange (ETDEWEB)

    Richmond, C.R.


    The toxicity of plutonium is discussed, particularly in relation to controversies surrounding the setting of radiation protection standards. The sources, amounts of, and exposure pathways of plutonium are given and the public risk estimated. (ACR)

  11. Plutonium controversy

    International Nuclear Information System (INIS)

    Richmond, C.R.


    The toxicity of plutonium is discussed, particularly in relation to controversies surrounding the setting of radiation protection standards. The sources, amounts of, and exposure pathways of plutonium are given and the public risk estimated

  12. Ignition and Growth Modeling of Detonating LX-04 (85% HMX / 15% VITON) Using New and Previously Obtained Experimental Data (United States)

    Tarver, Craig


    An Ignition and Growth reactive flow model for detonating LX-04 (85% HMX / 15% Viton) was developed using new and previously obtained experimental data on: cylinder test expansion; wave curvature; failure diameter; and laser interferometric copper and tantalum foil free surface velocities and LiF interface particle velocity histories. A reaction product JWL EOS generated by the CHEETAH code compared favorably with the existing, well normalized LX-04 product JWL when both were used with the Ignition and Growth model. Good agreement with all existing experimental data was obtained. Keywords: LX-04, HMX, detonation, Ignition and Growth PACS:82.33.Vx, 82.40.Fp This work was performed under the auspices of the U. S. Department of Energy by the Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344.

  13. New findings and old controversies in the research of multiple sclerosis and its model experimental autoimmune encephalomyelitis. (United States)

    Aharoni, Rina


    Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS that is heterogeneous in its clinical manifestation and progression, as well as in its pathological mechanisms. Animal models, in particular the various forms of experimental autoimmune encephalomyelitis, have been highly valuable for studying both disease pathology and drug development. Novel technologies, such as advanced imaging systems, as well as systematic research of CNS biopsies and postmortem samples from MS patients, have brought major progress in disease understanding. Consequently, in addition to the sclerotic demyelinated plaques in the white matter, changes in normal-appearing white matter tissue ('pre-plaque') and gray matter pathology are currently regarded as central disease components. This review aims to provide current insights on several central aspects in MS research. In particular, the interplay between inflammation and neurodegeneration mediating the disease, and therapeutic strategies attempting to induce immunomodulation and neuroprotective repair processes, are discussed.

  14. Biosystematic studies on Dactylis L. l. Review of the previous studies. 1.2. Cytology, genetics, experimental studies, and evolution

    Directory of Open Access Journals (Sweden)

    Marta Mizianty


    Full Text Available In this paper the author presents a review of the previous studies on Dactylis L., dealing with cytology,genetics, experimental studies and evolution. Following cytotypes of Dactylis are distributed mostly in Central Europe: 16 diploids, 7 tetraploids and also 2 hexaploids in North Africa. Some aneuploids and accessory chromosomes were also found in this genus. Data dealing with karyotypes of some taxa, and geographical distribution of cytotypes are also listed. Selected problems concerning crossing within diploids as well as tetraploids and also between diploids and teraploids were presented. Some opinions regarding the evolution in the genus Dactylis were also demonstrated. In all these hypotheses the following diploids are considered to be the oldest: D. smithii Link subsp. smithii, D. g. subsp. aschersoniana (Greabn. Thell. and D. g. subsp. himalayensis Dom.

  15. Influence of experimental distemper infection on the distribution of lead in dogs previously subacutely intoxicated with lead carbonate

    Energy Technology Data Exchange (ETDEWEB)

    White, D.J.; Marshall, A.J.; McLeod, S.


    The ability of experimental canine distemper infection to mobilize body lead deposits has been studied in Beagle dogs previously subacutely intoxicated with lead carbonate. For comparative purposes dogs were included which had either received lead only or distemper only or remained undosed. It was found that in dogs predosed with lead, distemper infection resulted in a significant increase in lead levels in blood and urine; this coincided with the peak body temperatures reached on the third day post infection. It was also found that the lead content of the liver and bone of these dogs was considerably higher than that of dogs receiving lead alone; at the same time bone phosphorus showed a marked decrease while bone calcium values remained similar to undosed controls.

  16. Controversial Books for Children. (United States)

    Hoffman, La Vinia Jean


    Discusses children's books which have caused controversies pertaining to ethnic stereotyping, labeling, sex instruction, and offensive language, and maintains that controversy is beneficial in that it keeps librarians aware of children's interests. (FM)

  17. Self-shielding effects in burnup of Gd used as burnable absorber. Previous studies on its experimental verification

    International Nuclear Information System (INIS)

    Abbate, Maximo J.; Sbaffoni, Maria M.


    Continuing with the domestic 'Burnable Absorbers Research Plan' studies were done to estimate self-shielding effects during Gd 2 O 3 burnup as burnable absorber included in fuel pins of a CAREM geometry. In this way, its burnup was calculated without and with self-shielding. For the second case, were obtained values depending on internal pin radius and the effective one for the homogenized pin. For Gd 157, the burnup corresponding to the first case resulted 52.6 % and of 1.23 % for the effective one. That shows the magnitude of the effects under study. Considering that is necessary to perform one experimental verification, also are presented calculational results for the case to irradiate a pellet containing UO 2 (natural) and 8 wt % of Gd 2 O 3 , as a function of cooling time, that include: measurable isotopes concentrations, expected activities, and photon spectra for conditions able to be compared with bidimensional calculations with self-shielding. The irradiation time was supposed 30 dpp using RA-3 reactor at 10 MW. (author)

  18. Experimental infection of one-day-old chicks with Salmonella Serotypes Previously isolated from poultry facilities, wild birds, and swine

    Directory of Open Access Journals (Sweden)

    E de Sousa


    Full Text Available In order to maintain the high production and export rates achieved by the Brazilian poultry industry, it is necessary to prevent and control certain disease agents, such as Salmonella spp. Using bacterial cultures, the aim of the present study was to investigate the prevalence of Salmonella spp. in specimens collected from broiler facilities. Local wild birds were also sampled, as well as the feces of swine housed on the poultry farm. After sample collection, the isolated serotypes were subsequently inoculated into broiler chicks to determine their effects. Positive samples were collected from the following locations in the poultry facilities: poultry litter (S. serotype 4,5,12:R:-; S. Heidelberg; S. Infantis, broiler feces (S. Heidelberg; S. serotype 6,7:R:-; S. serotype 4,5,12:R:-; S. Tennessee, water (S. Glostrup; S. serotype 6,8:d:-;, and lesser mealworms (Alphitobius diaperinus found in the litter (S. Tennessee. Among the 36 wild birds captured, S. Heidelberg was isolated from one bird's organs and intestinal contents (Colaptes campestris, and S. Enteritidis was isolated from another bird's intestinal contents (Zenaida auriculata. Salmonella Panama and Salmonella Typhimurium were isolated from swine feces. One-day-old chicks (150 were divided into 10 groups of 15 animals each. Each group was orally inoculated with a previously isolated serotype of Salmonella. Soft stools were observed on the cage floor and around the birds' cloaca between 3 and 12 days post-infection (dpi. The different serotypes of Salmonella used to inoculate the chicks were re-isolated from the spleen, liver, and cecal content samples of the infected birds on 15 and 21 dpi.

  19. Experimental Design of a Polymeric Solution to Improve the Mobility Ratio in a Reservoir previous implementation of a pilot project of EOR

    Directory of Open Access Journals (Sweden)

    Vanessa Cuenca


    Full Text Available This paper describes experimental formulations of polymeric solutions through lab evaluations with the objective of finding optimum solution concentration to fluid mobility in reservoirs as previous step before implementing a pilot project of enhanced oil recovery. The polymers, firstly, were selected based on the properties from fluids from reservoir. Two types of polymers were used TCC-330 and EOR909 and the experimental tests were: thermal stability, compatibility, adsorption, salinity, and displacement. The design with the best results was with polymer TCC-330 at 1,500 ppm concentration.

  20. Energy, controversies and prospects

    International Nuclear Information System (INIS)

    Bertholet, J.-L.; Garbely, M.; Lachal, B.; Romerio, F.; Weber, W.


    The energy debate raises deep controversies, as discussions on climate change or electricity markets' deregulation show. In this context, it is very difficult for the citizen to express himself in referendums and for the decision maker to slice between various options. Experts themselves deliver controversial evaluations and interest groups can benefit from them to suggest their own solution. This book enables to get a better insight and better understand energy-related controversies and the environmental and socio-economic impacts of energy. It deals with topics as complex and politically extreme as the exhaustion of fossil fuels, climate change, ionising radiations, renewable energy sources, energy consumption in Southern countries and the reorganisation of electricity markets. It starts with an article on the precaution principle and it ends with a glance on the future, devoted to education in the field of efficient energy use [fr

  1. Obstetric controversies in thyroidology

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    Ambika Gopalakrishnan Unnikrishnan


    Full Text Available It is well known that thyroid disorders commonly affect women. The care of pregnant women affected by thyroid disease is an important clinical challenge for endocrinologists. Hypothyroidism is the commonest problem, and maternal hypothyroxinemia has been linked to adverse feto-maternal outcomes. This article would discuss the controversy regarding first-trimester thyroid hormone deficiency and fetal brain development. Certain obstetric controversies in the management of hyperthyroidism in pregnancy, including the indications of TSH receptor antibody measurements and fetal thyroid status monitoring would also be discussed.

  2. A tale of two psychologies: The Høffding-Lehmann controversy and the establishment of experimental psychology at the University of Copenhagen. (United States)

    Pind, Jörgen L


    Alfred Lehmann (1858-1921) was the pioneer of experimental psychology in Denmark. He established a laboratory of psychophysics in Copenhagen in 1886 after spending a winter in Wundt's laboratory. Philosophical psychology had been taught for the better part of the nineteenth century at the University of Copenhagen and had enjoyed a positivistic turn with the philosophers Harald Høffding (1843-1931) and Kristian Kroman (1846-1925). Shortly after establishing his laboratory, Lehmann criticized Høffding's theory of "unmediated recognition," which led to a sharp dispute between them on the nature of recognition. It has been claimed that this was a direct cause of Lehmann's slow advance at the University of Copenhagen. Archival sources show that Høffding, though having a very different conception of psychology from Lehmann, was on most occasions supportive of Lehmann and thus played an important role in establishing experimental psychology at the University of Copenhagen. (c) 2009 Wiley Periodicals, Inc.

  3. Cartography of architectural controversies

    DEFF Research Database (Denmark)

    Lotz, Katrine


    that employing the visualising methods of the recent development of Actor-Network-Theory called ‘Cartography of Controversies' might contribute to trans-disciplinary efforts to develop analytic understanding of the conflicting human purposes and power-struggles at stake in the be-coming of architecture....


    African Journals Online (AJOL)

    Preferred Customer

    However, there are so many chemical reactions notably in organic chemistry where reactions may not directly lead to products. ... There are concepts that support these ideas but can they be proven to the ... Reaction mechanism is one such issue in organic chemistry that has attracted a lot of controversial comments from ...

  5. Controversial Messages on Cancer. (United States)

    Mustieles, Vicente; Olea, Nicolas; Sanchez, Maria Jose; Fernandez, Mariana F


    A direct connection between certain lifestyle factors and an increased risk of cancer has already been established. Despite well-documented associations, controversial messages on causes of cancer often appear without taking into consideration their impact on the general population. While mainstream coverage of cancer research is clearly welcome, consideration must be given to the risk of transmitting provocative messages with serious negative consequences for cancer research and public health. We must avoid becoming a breeding ground for the misinterpretation of scientific information. Polemical results can stimulate scientific research and progress, but controversial messages encourage confusion and impotence in an increasingly disoriented population. The correct communication of health messages is at least as important as research on risk factors.

  6. The Thimerosal Controversy


    Sutherland, Aimee


    Historically, there has always been a degree of concern related to vaccination. While public health policy in the early 1900s was more concerned with the contamination of vaccine vials with microbes, such as tetanus, that could cause serious illness and potentially death, current vaccination concerns are centered on the apprehension of chemicals ‘contaminating’ vaccines. The modern day vaccination controversy regarding chemical contamination began as a result of environmental concerns regardi...

  7. The pertussis vaccine controversy.


    Hinman, A R


    Over the past few years, there has been continuing controversy about whether the benefits of routine vaccination for pertussis outweight the potential risks. Some of the epidemiologic and technical issues include ascertainment and reporting of cases, case definition and laboratory confirmation, identification and purification of antigens, vaccine potency measurement, vaccine efficacy, and vaccine safety. Other factors include legal and economic issues, ethical concerns, emotional overlays, an...

  8. Controversies in Obesity Treatment

    Directory of Open Access Journals (Sweden)

    Majid Karandish


    Full Text Available The markedly high prevalence of obesity contributes to the increased incidence of chronic diseases, such as diabetes, hypertension, sleep apnea, and heart disease. Because of high prevalence of obesity in almost all countries, it has been the focus of many researches throughout the world during the recent decades. Along with increasing researches, new concepts and controversies have been emerged. The existing controversies on the topic are so deep that some researches argue on absolutely philosophical questions such as “Is obesity a disease?” or “Is it correct to treat obesity?” These questions are based on a few theories and real data that explain obesity as a biological adaptation and also the final results of weight loss programs. Many people attempt to lose weight by diet therapy, physical activity and lifestyle modifications. Importantly, weight loss strategies in the long term are ineffective and may have unintended consequences including decreasing energy expenditure, complicated appetite control, eating disorders, reducing self-esteem, increasing the plasma and tissue levels of persistent organic pollutants that promote metabolic complications, and consequently, higher risk of repeated cycles of weight loss and weight regain. In this review, major paradoxes and controversies on obesity including classic obesity paradox, pre-obesity; fat-but-fit theory, and healthy obesity are explained. In addition, the relevant strategies like “Health at Every Size” that emphasize on promotion of global health behaviors rather than weight loss programs are explained.


    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen


    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity.

  10. Mapping Wind Energy Controversies

    DEFF Research Database (Denmark)

    Munk, Anders Kristian

    As part the Wind2050 project funded by the Danish Council for Strategic Research we have mapped controversies on wind energy as they unfold online. Specifically we have collected two purpose built datasets, a web corpus containing information from 758 wind energy websites in 6 different countries......, and a smaller social media corpus containing information from 14 Danish wind energy pages on Facebook. These datasets have been analyzed to answer questions like: How do wind proponents and opponents organize online? Who are the central actors? And what are their matters of concern? The purpose of this report...

  11. Trending Cardiovascular Nutrition Controversies. (United States)

    Freeman, Andrew M; Morris, Pamela B; Barnard, Neal; Esselstyn, Caldwell B; Ros, Emilio; Agatston, Arthur; Devries, Stephen; O'Keefe, James; Miller, Michael; Ornish, Dean; Williams, Kim; Kris-Etherton, Penny


    The potential cardiovascular benefits of several trending foods and dietary patterns are still incompletely understood, and nutritional science continues to evolve. However, in the meantime, a number of controversial dietary patterns, foods, and nutrients have received significant media exposure and are mired by hype. This review addresses some of the more popular foods and dietary patterns that are promoted for cardiovascular health to provide clinicians with accurate information for patient discussions in the clinical setting. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  12. The animal experimentation controversy: Ethical views of ...

    African Journals Online (AJOL)

    ... and scientific research. The responses were analysed qualitatively and quantitatively. The results showed that most prospective teachers are in favour of animal rights and that females are more averse to vivisection than males. A number of suggestions are made with regard to vivisection in schools and tertiary institutions.

  13. Siting controversial facilities

    International Nuclear Information System (INIS)

    Baird, R.D.; Blacker, P.B.


    There is often significant difficulty involved with siting controversial facilities. The social and political problems are frequently far more difficult to resolve than the technical and economic issues. The tendancy for most developing organizations is to address only technical issues in the search for a technically optimal site, to the exclusion of such weighting considerations as the social and political climate associated with potential sites--an approach which often imperils the success of the project. The site selection processes currently suggested is summarized and two contemporary examples of their application are cited. The difference between developers' real objectives and the objectives they have implicitly assumed by adopting the recommended approaches without augmentation are noted. The resulting morass of public opposition is attributed to the failure to consider the needs of individuals and groups who stand to be negatively impacted by the development. A comprehensive implementation strategy which addresses non-technical consideration in parallel with technical ones is presented and evaluated

  14. Teen Addiction. Current Controversies Series. (United States)

    Winters, Paul A., Ed.

    The Current Controversies series explores social, political, and economic controversies that dominate the national and international scenes today from a variety of perspectives. Recent surveys have shown that, after years of decline, drug use among teenagers has increased during the 1990s, and that alcohol and tobacco use have remained…

  15. American Migration Controversies


    Milan Mesić


    The USA has been and has remained the world's most important immigration country. The last quarter of the 20th century has been marked by a new mass immigration wave that in absolute size of the immigration flow can be compared to the highest flows in the previous century. This recent migration, however, differs from traditional immigration to America in that it includes a greater ethnic, religious and cultural diversity. The vast majority of today's immigrants, both legal and clandestine, co...

  16. Examination of virus shedding in semen from vaccinated and from previously infected boars after experimental challenge with porcine reproductive and respiratory syndrome virus

    DEFF Research Database (Denmark)

    Nielsen, Thomas L.; Nielsen, Jens; Have, Per


    to the Danish pig industry. The use of a vaccination-program may be a way to avoid or reduce the problem, This study evaluates the use of two vaccines: One live, attenuated vaccine and one inactivated vaccine, A pronounced reduction in viremia and shedding of virus in semen was demonstrated by use of the live...... vaccine compared to the non-vaccinated control animals. In contrast, no changes in onset, level and duration of viremia and shedding of virus in semen were observed using the inactivated vaccine, Neither viremia nor seminal shedding of virus was detected in previously PRRSV-infected, PRRSV...

  17. Controversy surrounding 'mini' gastric bypass. (United States)

    Mahawar, Kamal K; Carr, William R J; Balupuri, Shlok; Small, Peter K


    Mini gastric bypass is a modification of Mason loop gastric bypass with a longer lesser curvature-based pouch. Though it has been around for more than 15 years, its uptake by the bariatric community has been relatively slow, and the procedure has been mired in controversy right from its early days. Lately, there seems to be a surge in the interest in this procedure, and there is now published experience with more than 5,000 procedures globally. This review examines the major controversial aspects of this procedure against the available scientific literature. Surgeons performing this procedure need to be aware of these controversies and counsel their patients appropriately.

  18. Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection

    Directory of Open Access Journals (Sweden)

    L. Martorelli


    Full Text Available Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with either 108 or 1010 CFU, as well as the ability of specific preexisting antibodies to reduce shedding of the pathogen. Shedding was analysed by direct counting as well as enrichment of rectoanal mucosal swabs. Statistical analysis was performed using a linear model for repeated measures with and without the inclusion of preexisting antibodies against the carboxy-terminal fraction of intimin-γ (γ-intimin C280 as a covariable. Results suggest that there is a statistical difference in the area under the shedding curves between both doses for 14 as well as 28 days after challenge (p = 0.0069 and 0.0209, resp.. This difference is increased when the prechallenge antibodies are taken into account (p = 0.0056 and 0.0185. We concluded that the bacterial dose influences shedding on calves experimentally challenged and that preexisting antibodies against E. coli O157:H7 γ-intimin C280 could partially reduce faecal excretion.

  19. Partisan Scholarship in Technoscientific Controversies

    DEFF Research Database (Denmark)

    Galis, Vasilis; Hansson, Anders


    Several academic traditions have addressed epistemological objectivity and/or partisanship in the study of technoscientific controversies. On the one hand, positivist and relativist scholars agree that the political commitments of the social researcher should not impinge on scientific enquiry...

  20. Phosphorus status of diverse soils in Finland as influenced by long-term P fertilisation I.Native and previously applied P at 24 experimental sites

    Directory of Open Access Journals (Sweden)



    Full Text Available The native reserves of phosphorus (P in Finnish soils are sizeable but poorly available to plants. The P status has been generally poor, but large rates of P applied since the 1940s have substantially enhanced the supply of P from the soil. As a means of optimising P fertilisation of crops grown in the improved soils and promoting agro-environmental sustainability of agriculture, long-term field experiments were established in 1977-1981 on various soil types around Finland, between the latitudes of 60 and 65 N. The experimental sites (8 Cambisols, 9 Regosols, 6 Histosols, 1 Podsol were moderately acidic (pH w 5.6, range 4.6-6.6 and contained 1.6-31.2% organic C, and (mineral soils 3-74% clay. The concentration of total P was 1.22 (0.66-1.87 g kg -1 , and the inorganic fraction separated with fluoride and hydroxide extractions (Al,Fe-P was 8.2% (4.5-12.4% of oxalate extractable Al+Fe (P saturation index. In mineral topsoil the pool of Al,Fe-P was 850 kg ha -1 , which is 300 kg ha -1 larger than was obtained in the early 1960s and 600 kg ha -1 larger than found in virgin soils. The soil test P value was 13.1 (3.7-60 mg dm -3 by the acid ammonium acetate method, 11.5 (1.6-42 mg dm -3 by a water extraction method (1:60 v/v and 61 (23-131 mg kg -1 with a modified Olsen method. The intensity factor of soil P status has remained at a relatively low level in a major part of the cultivated area.;

  1. Experimental paracoccidioidomycosis in the mouse. III. Histopathological and immunological findings after intravenous infection in the presence or absence of previous immunization

    Directory of Open Access Journals (Sweden)

    Maura Moscardi Bacchi


    Full Text Available Fifty male white Swiss mice aged 4 weeks were inoculated with 5 x 10(5 viable yeast forms of Paracoccidioides brasiliensis (strain 18. Ten of these animals had been previously immunized with particulate P. brasiliensis antigenfor 4 weeks by intradermal injection. The controls consisted of 10 animals that were only immunized and 10 animals submitted to no treatment. The animals were sacrificed 2, 4, 7,11 and 16 weeks later. We studied: 1 the anti-P. brasiliensis delayed hypersensitivity response measured by the footpad test 24 hours prior to sacrifice; 2 the specific antibody production measured by double immunodiffusion in agar gel; 3 the histopathology of lungs, liver, spleen, adrenals and kidneys. We observed that: a the immunized animals developed more intense cell-immune responses than the infected ones; b infection reduced the cell- immune response of the immunized animals; c intravenous infection of mice with P. brasiliensis was characterized by a systemic and progressive granulomatous inflammation. The animals infected after previous immunization showed less extensive lung inflammation, with smaller granulomas and fewer fungi. The results indicate that the present murine model mimics some findings of the human subacute form of paracoccidioidomycosis (systemic disease with depressed cellular immunity and that the extrapulmonary immunization scheme was able to induce a certain degree of protection of the lung from infection with P. brasiliensisCinqüenta camundongos suíços, brancos, com quatro semanas de idade, foram inoculados com 5x10(5 formas leveduriformes, viáveis de Paracoccidiodes brasiliensis (cepa 18. Dez destes animais tinham sido previamente imunizados com antígeno particulado de P. brasiliensis, durante quatro semanas, por injeção intradérmica. Os controles consistiram de 10 animais que foram somente imunizados e 10 inoculados com solução salina estéril. Os animais foram sacrificados após 2, 4, 7, 11 e 16 semanas

  2. Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II. The innate immune response shows immunological memory: reality or fiction? (United States)

    Basso, B; Marini, V


    Trypanosoma cruzi is a real challenge to the host's immune system, because it requires strong humoral and cellular immune response to remove circulating trypomastigote forms, and to prevent the replication of amastigote forms in tissues, involving many regulator and effector components. This protozoan is responsible for Chagas disease, a major public health problem in Latinamerica. We have developed a model of vaccination with Trypanosoma rangeli, a parasite closely related to T. cruzi, but nonpathogenic to humans, which reduces the infectiousness in three different species of animals, mice, dogs and guinea pigs, against challenge with T. cruzi. In a previous work, we demonstrated that mice vaccinated with T. rangeli showed important soluble mediators that stimulate phagocytic activity versus only infected groups. The aim of this work was to study the innate immune response in mice vaccinated or not with T. rangeli. Different population cells and some soluble mediators (cytokines) in peritoneal fluid and plasma in mice vaccinated-infected and only infected with T. cruzi were studied. In the first hours of challenge vaccinated mice showed an increase of macrophages, NK, granulocytes, and regulation of IL6, IFNγ, TNFα and IL10, with an increase of IL12, with respect to only infected mice. Furthermore an increase was observed of Li T, Li B responsible for adaptative response. Finally the findings showed that the innate immune response plays an important role in vaccinated mice for the early elimination of the parasites, complementary with the adaptative immune response, suggesting that vaccination with T. rangeli modulates the innate response, which develops some kind of immunological memory, recognizing shared antigens with T. cruzi. These results could contribute to the knowledge of new mechanisms which would have an important role in the immune response to Chagas disease. Copyright © 2014 Elsevier GmbH. All rights reserved.

  3. Global Banning of a Diffused Controversial Practice

    DEFF Research Database (Denmark)

    Gurses, Kerem; Giones, Ferran; Mehta, Kandarpkumar


    We study the deinstitutionalization of a controversial practice that had previously reached a level of international diffusion. We draw on international diffusion and deinstitutionalization theory to study the emergence and diffusion of the third-party ownership practice in the soccer industry. We...... use an inductive case study combining archival and interview data to study the determinants of the international diffusion of a controversial practice at a global scale, the contestation, and finally the deinstitutionalization process that resulted from the ban of the practice. We find...... that the opacity of the practice can be a diffusion driver, locally and at the international level, nevertheless the opacity also may lead to different meaning creation attempts and potential discursive battles between actors, and eventually to deinstitutionalization of the practice. This article advances our...

  4. Controversy undermines support for state mandates on the human papillomavirus vaccine. (United States)

    Gollust, Sarah E; Dempsey, Amanda F; Lantz, Paula M; Ubel, Peter A; Fowler, Erika Franklin


    State actions requiring adolescent girls to receive the human papillomavirus (HPV) vaccine created controversy following the vaccine's approval in 2006. Some health professionals worried that the controversy might dampen public support for those state policies and for other school immunizations in general. We fielded an experimental Internet survey to determine how controversy affects attitudes about vaccines. We discovered that public support for the HPV vaccine mandates wanes when the public is informed that the policies are controversial. However, the experimental survey also revealed that exposure to this policy controversy did not spill over and reduce public support for immunizations in general.

  5. The Satanic Ritual Abuse Controversy. (United States)

    Putnam, Frank W.


    The issues raised by Jonker and Jonker-Bakker and Young et al (EC 601 187-188) illustrate a major controversy dividing the child abuse community, the alleged existence of a conspiracy of satanic, ritual, sexual abuse of children. No evidence is found to support claims that large numbers of babies and children are being sacrificed or abused in…

  6. Current controversies, is there merit?

    DEFF Research Database (Denmark)

    Twetman, S


    Xylitol has become a debated measure in caries prevention. This paper aims to examine and comment on some possible controversies, with emphasis on the most recent literature. A search for clinical trials was conducted through 2007 in PubMed, and papers describing a controlled xylitol intervention...

  7. Societal Controversies in Wikipedia Articles

    NARCIS (Netherlands)

    Borra, E.; Weltevrede, E.; Ciuccarelli, P.; Kaltenbrunner, A.; Laniado, D.; Magni, G.; Mauri, M.; Rogers, R.; Venturini, T.


    Collaborative content creation inevitably reaches situations where different points of view lead to conflict. We focus on Wikipedia, the free encyclopedia anyone may edit, where disputes about content in controversial articles often reflect larger societal debates. While Wikipedia has a public edit

  8. Organic Reaction Mechanism Controversy: Pedagogical ...

    African Journals Online (AJOL)

    The paper investigated the pedagogical implications of the controversy generated by the nature of reaction mechanism in organic chemistry as to whether it can be proven or not. A conference of a chemist, chemical educator, a graduate chemistry teacher and a graduate assistant was organized. The conference lasted for ...

  9. Darwinian Controversies: An Historiographical Recounting (United States)

    Depew, David J.


    This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race,…

  10. Controversies in neurosciences critical care. (United States)

    Chang, Tiffany R; Naval, Neeraj S; Carhuapoma, J Ricardo


    Neurocritical care is an evolving subspecialty with many controversial topics. The focus of this review is (1) transfusion thresholds in patients with acute intracranial bleeding, including packed red blood cell transfusion, platelet transfusion, and reversal of coagulopathy; (2) indications for seizure prophylaxis and choice of antiepileptic agent; and (3) the role of specialized neurocritical care units and specialists in the care of critically ill neurology and neurosurgery patients. Copyright © 2012 Elsevier Inc. All rights reserved.

  11. Climate Change: Consensus or Controversy?


    Nicholls, Neville


    The hundreds of scientists comprising the Intergovernmental Panel on Climate Change (IPCC) maintain that there is a consensus that humans are changing the global climate. Yet many commentators in the media dispute this, and a reader of such commentaries would surely conclude that climate change is a controversy rather than a consensus. This is simply incorrect – the overwhelming majority of climate scientists accept the reality of the greenhouse effect and its impact on the current climate. T...

  12. Controversies in Facial Cosmetic Surgery. (United States)

    Retana, Armando


    Facial cosmetic surgery techniques are constantly updated to meet the expectations of patients who demand less invasive procedures and less recovery time. Current trends in lower eyelid surgery call for periorbital fat repositioning instead of excision of fat. Controversies still exist in chin augmentations regarding osseous genioplasty versus alloplastic chin implant. The benefits, disadvantages, and considerations of these procedures are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. HPV vaccines: a controversial issue?


    Nicol, A.F.; Andrade, C.V.; Russomano, F.B.; Rodrigues, L.L.S.; Oliveira, N.S.; Provance, D.W.


    Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment o...

  14. Societal Controversies in Wikipedia Articles


    Borra, E.; Weltevrede, E.; Ciuccarelli, P.; Kaltenbrunner, A.; Laniado, D.; Magni, G.; Mauri, M.; Rogers, R.; Venturini, T.


    Collaborative content creation inevitably reaches situations where different points of view lead to conflict. We focus on Wikipedia, the free encyclopedia anyone may edit, where disputes about content in controversial articles often reflect larger societal debates. While Wikipedia has a public edit history and discussion section for every article, the substance of these sections is difficult to phantom for Wikipedia users interested in the development of an article and in locating which...

  15. Controversial reversal of nuclear option


    Mesarović Miodrag


    Nuclear option is in a unique position to restore its original role of the main source of energy with an increased attention paid to the security of electricity supply as well as regulatory changes affecting fossil fuels, particularly with due introduction of climate change prevention measures. Recent developments indicate the advantages of nuclear option over other possible options in terms of sustainable development. However, a large number of controversial issues on nuclear energy make its...

  16. Sexual Orientation, Controversy, and Science. (United States)

    Bailey, J Michael; Vasey, Paul L; Diamond, Lisa M; Breedlove, S Marc; Vilain, Eric; Epprecht, Marc


    SummaryOngoing political controversies around the world exemplify a long-standing and widespread preoccupation with the acceptability of homosexuality. Nonheterosexual people have seen dramatic surges both in their rights and in positive public opinion in many Western countries. In contrast, in much of Africa, the Middle East, the Caribbean, Oceania, and parts of Asia, homosexual behavior remains illegal and severely punishable, with some countries retaining the death penalty for it. Political controversies about sexual orientation have often overlapped with scientific controversies. That is, participants on both sides of the sociopolitical debates have tended to believe that scientific findings-and scientific truths-about sexual orientation matter a great deal in making political decisions. The most contentious scientific issues have concerned the causes of sexual orientation-that is, why are some people heterosexual, others bisexual, and others homosexual? The actual relevance of these issues to social, political, and ethical decisions is often poorly justified, however. © The Author(s) 2016.

  17. Military laser weapons: current controversies. (United States)

    Seet, B; Wong, T Y


    Military laser weapons systems are becoming indispensable in most modern armies. These lasers have undergone many stages of development, and have outpaced research on eye protection measures, which continue to have inherent limitations. Eye injuries caused by military lasers are increasingly reported, leading to speculation that these would become an important cause of blinding in modern conflicts. As part of the effort to ban inhumane weapons, international laws have been passed to restrict the proliferation of such blinding weapons. However, there are controversies concerning the interpretation, implementation and effectiveness of these laws. The ophthalmic community can play a greater role in highlighting ocular morbidity from military lasers, and in preventing their further proliferation.

  18. The controversy about nuclear power

    International Nuclear Information System (INIS)

    Bethe, H.A.


    A short review of the events of the past several years in the conflict in the USA between the groups supporting or opposing nuclear power. Reference is made to publications on both sides of the controversy which the author considers to be well reasoned and useful sources of information. Mention is also made of the legal and legislative actions taken by both sides. The arguments against nuclear power are summarized and solutions to the problems which are the source of these arguments are suggested

  19. Glaciers in Patagonia: Controversy and prospects (United States)

    Kargel, J. S.; Alho, P.; Buytaert, W.; Célleri, R.; Cogley, J. G.; Dussaillant, A.; Guido, Z.; Haeberli, W.; Harrison, S.; Leonard, G.; Maxwell, A.; Meier, C.; Poveda, G.; Reid, B.; Reynolds, J.; Rodríguez, C. A. Portocarrero; Romero, H.; Schneider, J.


    Lately, glaciers have been subjects of unceasing controversy. Current debate about planned hydroelectric facilities—a US7- to 10-billion megaproject—in a pristine glacierized area of Patagonia, Chile [Romero Toledo et al., 2009; Vince, 2010], has raised anew the matter of how glaciologists and global change experts can contribute their knowledge to civic debates on important issues. There has been greater respect for science in this controversy than in some previous debates over projects that pertain to glaciers, although valid economic motivations again could trump science and drive a solution to the energy supply problem before the associated safety and environmental problems are understood. The connection between glaciers and climate change—both anthropogenic and natural—is fundamental to glaciology and to glaciers' practical importance for water and hydropower resources, agriculture, tourism, mining, natural hazards, ecosystem conservation, and sea level [Buytaert et al., 2010; Glasser et al., 2011]. The conflict between conservation and development can be sharper in glacierized regions than almost anywhere else. Glaciers occur in spectacular natural landscapes, but they also supply prodigious exploitable meltwater.

  20. Current controversies in childhood vaccination. (United States)

    Carrillo-Marquez, Maria; White, Lisa


    As pediatric practitioners, one of the contemporary challenges in providing medical care for children is the increasing proportion of vaccination refusal. This occurs in spite of the demonstrated individual and collective benefit and cost effectiveness of vaccination. Controversies regarding vaccine components and side effects have misled parents to believe that vaccines might be harmful based on inaccurate data from the Internet, celebrities, as well as misinterpreted and frankly bad science. This belief of vaccines being harmful has led to fear and decreased immunization rates in spite of sound scientific evidence supporting the safety of vaccines and their lack of association with autism, developmental disabilities or other medical disorders. Some parents also believe in alternative ways to avoid disease, often adhering to practices that have little foundation in the best of empiric science. It is not a coincidence that recent outbreaks of vaccine-preventable diseases, including measles and pertussis (whooping cough), have occurred in areas where vaccination has declined largely due to exemptors. This article intends to review some of the common vaccine myths and controversies and to serve as a resource to provide accurate information and references for busy practitioners and the families that we serve.


    African Journals Online (AJOL)


    PREVIOUS SECOND TRIMESTER ABORTION: A risk factor for third trimester uterine rupture in three ... for accurate diagnosis of uterine rupture. KEY WORDS: Induced second trimester abortion - Previous uterine surgery - Uterine rupture. ..... scarred uterus during second trimester misoprostol- induced labour for a missed ...

  2. Doctrinal controversies and ecumenical councils | Ogbonnaya ...

    African Journals Online (AJOL)

    This work focused on the doctrinal controversies that have confronted the Church in the course of its development and the accompanying councils that sought to resolve these theological controversies. The paper did this historically, by showing the origin of the problems, the factors and features involved in the controversies ...

  3. Cartography of Controversies about MOOCs

    DEFF Research Database (Denmark)

    Khalid, Md. Saifuddin; Sorensen, Elsebeth Korsgaard


    Massively open online courses (MOOCs) are one of most recent educational technology development that have become a highly debated issue, polarized among proponents, boosters, skeptics, and resistants. To understand the nature of such evolving technology concepts, the typical methods and techniques...... studies (STS) discipline. The method guides the application of actor network theory (ANT). Online digital media and tools (namely, Scopus, ScienceScape, Google trends, OpenHeatMap, NodeXL, Gephi, Facebook, Twitter) are used for data collection and analysis. The study uses both qualitative and quantitative...... tools and techniques to highlight the statements, literatures, actors, cosmoses or general concepts involved in the controversy. The paper propounds the adoption of the method in the field of education and educational technology and proposes through demonstration in this article that such investigations...

  4. Managing Controversies in the Fuzzy Front End

    DEFF Research Database (Denmark)

    Christiansen, John K.; Gasparin, Marta


    This research investigates the controversies that emerge in the fuzzy front end (FFE) and how they are closed so the innovation process can move on. The fuzzy front has been characterized in the literature as a very critical phase, but controversies in the FFE have not been studied before....... The analysis investigates the microprocesses around the controversies that emerge during the fuzzy front end of four products. Five different types of controversies are identified: profit, production, design, brand and customers/market. Each controversy represents a threat, but also an opportunity to search...... demonstrates how the fuzzy front requires managers to deal with controversies that emerge from many different places and involve both human and non-human actors. Closing the controversies requires managers to take account of the situation, identify the problem that needs to be addressed, and initiate a search...

  5. Darwinian Controversies: An Historiographical Recounting (United States)

    Depew, David J.


    This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race, culture, and eugenics at the 1959 centenary celebration Darwin’s Origin of Species; adaptationism and its critics in the Sociobiology debate of 1970s and, more recently, Evolutionary Psychology; and current disputes about Intelligent Design. These controversies, I argue, are etched into public memory because they occur at the emotionally charged boundaries between public-political, technical-scientific, and personal-religious spheres of discourse. Over most of them falls the shadow of eugenics. The main lesson is that the history of Darwinism cannot be told except by showing the mutual influence of the different norms of discourse that obtain in the personal, technical, and public spheres. Nor can evolutionary biology successfully be taught to citizens and citizens-to-be until the fractious intersections between spheres of discourse have been made explicit. In the course of showing why, I take rival evolutionary approaches to be dynamical historical research traditions rather than static theories. Accordingly, I distinguish Darwin’s version of Darwinism from its later transformations. I pay special attention to the role Darwin assigned to development in evolution, which was marginalized by twentieth-century population genetical Darwinism, but has recently resurfaced in new forms. I also show how the disputed phrases “survival of the fittest” and “social Darwinism” have shaped personal anxieties about “Darwinism,” have provoked public opposition to teaching evolution in public schools, and have cast a shadow over efforts to effectively communicate to the public largely successful technical efforts to make

  6. Review of the recent carbon dioxide-climate controversy

    International Nuclear Information System (INIS)

    Luther, F.M.; Cess, R.D.


    Model calculations of the climatic impact of the increasing atmospheric carbon dioxide (CO 2 ) concentration consistently suggest that a doubling of the CO 2 concentration would lead to a warming of global average surface air temperatures by as much as several degrees Celsius. In this appendix, this controversy about the effect of CO 2 on climate is reviewed. Because the surface energy balance approach to estimating climate sensitivity has been the source of much of the controversy, a review of this approach is presented. It is shown that prior applications of this approach violate the law of conservation of energy (the first law of thermodynamics); therefore, these results are incorrect. Empirical data indicating the relationship between atmospheric emittance and surface vapor pressure and surface air temperature are shown to be consistent with climate model calculations. Consequently, it is not the experimental data that are the basis of the controversy, but rather the analysis and interpretation of these data

  7. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak


    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  8. The HPV vaccine mandate controversy. (United States)

    Haber, Gillian; Malow, Robert M; Zimet, Gregory D


    In this editorial we address the controversies surrounding human papillomavirus (HPV) vaccine school-entry mandate legislation, but differentiate between the mandate debate and issues specific to the vaccine itself. Our goal is not to take a stand in favor of or opposed to mandates, but rather to critically examine the issues. We discuss the following arguments against HPV vaccine school-entry requirements: 1. The public health benefit of mandated HPV vaccination is not sufficient to warrant the intrusion on parental autonomy; 2. A vaccine that prevents a non-casually transmitted infection should not be mandated; 3. Opt-out provisions are inherently unfair to parents who oppose HPV vaccination; 4. Limited health care dollars should not be directed toward cervical cancer prevention; and 5. The vaccine is expensive and potential problems with supply suggest that mandates should not be implemented until insurance coverage and supply issues are resolved. Next, we critically evaluate the following critiques of HPV vaccination itself: 1. Giving girls HPV vaccine implies tacit consent to engage in sexual activity; 2. Giving girls this vaccine will confer a false sense of protection from sexually transmitted infections and will lead to sexual disinhibition; 3. Children already have too many vaccinations on the immunization schedule; 4. Long-term side effects of HPV vaccine are unknown; 5. The vaccine's enduring effectiveness is unknown and booster shots may be required; and 6. It is wrong to only target girls with HPV vaccine; boys should be vaccinated as well.

  9. Lyme disease: why the controversy? (United States)

    Beaman, M H


    Some Australians have become convinced of the existence of locally acquired Lyme disease (LD). The history of LD, since its recognition in the early 1970s, is reviewed as a model for investigative approaches to unknown syndromes. Australian Management Guidelines for LD include the requirement for diagnostic testing by National Association of Testing Authorities-accredited laboratories using Therapeutic Goods Administration-licensed tests, which result in the efficient diagnosis of LD in overseas travellers. Despite this, patients who have not left Australia pay many thousands of dollars for non-specialist consultations and testing at overseas laboratories. Unproven long-term therapy with multiple antibiotics has resulted in serious complications, including allergies, line sepsis, pancreatitis and pseudomembranous colitis. Studies have shown that LD vectors are not found in Australia, and Lyme Borrelia has not been found in Australian vectors, animals or patients with autochthonous illnesses. I propose that (i) A non-controversial name for the chronic syndrome should be adopted, 'Australian Multisystem Disorder'. (ii) Research funding should enable the development of a consensus case definition and studies of the epidemiology of this syndrome with laboratory investigations to identify an aetiology and surrogate markers of disease. Prospective, randomised treatment studies could then be undertaken using ethical protocols. © 2016 Royal Australasian College of Physicians.

  10. HPV vaccines: a controversial issue?

    Directory of Open Access Journals (Sweden)

    A.F. Nicol


    Full Text Available Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits.

  11. HPV vaccines: a controversial issue? (United States)

    Nicol, A F; Andrade, C V; Russomano, F B; Rodrigues, L L S; Oliveira, N S; Provance, D W


    Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits.

  12. Congruency sequence effects are driven by previous-trial congruency, not previous-trial response conflict


    Weissman, Daniel H.; Carp, Joshua


    Congruency effects in distracter interference tasks are often smaller after incongruent trials than after congruent trials. However, the sources of such congruency sequence effects (CSEs) are controversial. The conflict monitoring model of cognitive control links CSEs to the detection and resolution of response conflict. In contrast, competing theories attribute CSEs to attentional or affective processes that vary with previous-trial congruency (incongruent vs. congruent). The present study s...

  13. Evolutionary Psychology: Controversies, Questions, Prospects, and Limitations (United States)

    Confer, Jaime C.; Easton, Judith A.; Fleischman, Diana S.; Goetz, Cari D.; Lewis, David M. G.; Perilloux, Carin; Buss, David M.


    Evolutionary psychology has emerged over the past 15 years as a major theoretical perspective, generating an increasing volume of empirical studies and assuming a larger presence within psychological science. At the same time, it has generated critiques and remains controversial among some psychologists. Some of the controversy stems from…

  14. Nuclear Weapons: Concepts, Issues, and Controversies. (United States)

    Reardon, Betty; And Others


    The schools must confront and deal with the issues of the nuclear weapons controversy on pain of ceasing to be relevant to the critical needs of the rising generation. Every aspect of the nuclear arms controversy needs to be discussed in secondary and university classrooms. (RM)

  15. Hydroelectric power is green, although controversial

    International Nuclear Information System (INIS)

    Schulp, A.


    Hydroelectric power is worldwide the most important source of renewable energy. Still, it has some controversial aspects, which are briefly discussed in this article, focusing on Belgium and the Netherlands [nl

  16. Controversies in Persistent (Chronic) Lyme Disease (United States)


    The Centers for Disease Control and Prevention estimates that more than 300 000 new cases of Lyme disease occur each year in the United States and that 10% to 20% of these patients will remain symptomatic despite receiving appropriate antibiotic therapy. Many elements of the disease are poorly understood and have generated considerable controversy. This paper discusses the medical controversies related to posttreatment manifestations and their potential impact on infusion nurses. PMID:27755213

  17. How science makes environmental controversies worse

    International Nuclear Information System (INIS)

    Sarewitz, Daniel


    I use the example of the 2000 US Presidential election to show that political controversies with technical underpinnings are not resolved by technical means. Then, drawing from examples such as climate change, genetically modified foods, and nuclear waste disposal, I explore the idea that scientific inquiry is inherently and unavoidably subject to becoming politicized in environmental controversies. I discuss three reasons for this. First, science supplies contesting parties with their own bodies of relevant, legitimated facts about nature, chosen in part because they help make sense of, and are made sensible by, particular interests and normative frameworks. Second, competing disciplinary approaches to understanding the scientific bases of an environmental controversy may be causally tied to competing value-based political or ethical positions. The necessity of looking at nature through a variety of disciplinary lenses brings with it a variety of normative lenses, as well. Third, it follows from the foregoing that scientific uncertainty, which so often occupies a central place in environmental controversies, can be understood not as a lack of scientific understanding but as the lack of coherence among competing scientific understandings, amplified by the various political, cultural, and institutional contexts within which science is carried out. In light of these observations, I briefly explore the problem of why some types of political controversies become 'scientized' and others do not, and conclude that the value bases of disputes underlying environmental controversies must be fully articulated and adjudicated through political means before science can play an effective role in resolving environmental problems

  18. Contrasting Controversies: Fracking and Climate Change (United States)

    Duggan-Haas, D.; Zabel, I. H. H.; Ross, R. M.


    Slickwater high-volume hydraulic fracturing (commonly known as "fracking") is highly controversial. So is global warming, and the two issues are closely related, but the natures of these two controversies have substantial and important differences. Building upon years of experience in teaching and developing resources and strategies for teaching about evolution and climate change, staff at the Paleontological Research Institution have engaged in public outreach and educator professional development to help nurture understanding of fracking and the broader energy system. How are these controversies similar to and different from one another, and how should understanding these similarities and differences inform educational programming (and about how you talk about these issues with your Uncle Fred at the family holiday dinner?). It is nearly universally agreed amongst scientists who study climate that changes now underway are real and human caused, and are posing or likely to pose very serious problems for humanity. Scientists who study slickwater high-volume hydraulic fracturing agree that it causes environmental damage, but there is no consensus as to whether fracking causes more or less harm (e.g., among different kinds of environment harm, across different temporal and spatial scales, and among different social contexts) than other ways of producing energy on a large scale. In other words, the basic tenets of climate change are not a matter of scientific controversy, though the implications for policy making obviously remain politically controversial, while fracking is an issue of both scientific and political controversy. Without advocating for or against fracking, we help audiences disentangle scientific and political issues, better understand the energy resources used in their own communities, and consider issues of scale, systems, and complexity. We will compare and contrast the overlapping controversies surrounding climate change and fracking and highlight

  19. The words of controversy about climate change

    International Nuclear Information System (INIS)

    Chetouani, Lamria


    The author analyses the rhetorical staging of controversies which occur in France about climate change, and more particularly about the greenhouse effect. In a first part, she makes a distinction between four registers of controversy: on responsibilities, on consequences and extent of the phenomenon, on solutions, and on spatio-temporal projections of the greenhouse effect. She shows that debates are structured by an opposition between optimism and pessimism. In a second part, based on a lexicological analysis, she highlights the important oppositions between scientific speeches and political speeches, independent speeches and technocratic speeches, and so on, with unexpected aspects. It appears that controversy goes largely beyond the scientific debate, and incorporates crossed interventions of economic, political and social concern

  20. The first Pico-Ficino Controversy

    DEFF Research Database (Denmark)

    Aasdalen, Unn Irene


    in an attempt to throw light upon their further disagreement about the Platonic philosophy of love. The first Pico-Ficino controversy is in part played out over Florentine poetry, but does not have poetry as its prime concern. In essence, the miniature dispute about the Donna me prega encapsulates a grand......-scale conflict regarding how to live and die according to Platonic ideals. The themes of the controversy are firstly the interpretation of Plato’s Symposium, in particular Diotima’s speech, and secondly the practical conclusions one should draw from Plato’s fictional banquet. Ficino’s position is presented...

  1. 'Mysticism' in quantum mechanics: the forgotten controversy

    International Nuclear Information System (INIS)

    Marin, Juan Miguel


    This paper argues that a European controversy over a 'mystical' hypothesis, one assigning the mind a role to play at the material level of reality, shaped much of the debate over the interpretation of the quantum equations. It traces back the controversy to the past two decades, beginning in the late 1920s-birth of quantum theory-and concluding with Erwin Schroedinger's lectures published as 'Mind and Matter'. Becoming aware of the issues at stake can help us understand the historical, philosophical and cultural background from which today's physics emerged

  2. Anticipation and Controversy Surround "Superman" Release (United States)

    Aarons, Dakarai I.


    Well in advance of its official release, the education film "Waiting For Superman" has attracted a level of attention that could make it one of the year's most-watched documentaries--and one of the most controversial among educators, some of whom question its depictions of the American school system and how to improve it. Made by…

  3. Controversial Therapies: A Review and Critique. (United States)

    Rooney, Karen J.


    The article offers guidelines to educators evaluating controversial therapies and applies them to four such therapies: tinted lenses as a cure for dyslexia; orthomolecular treatments for learning disabilities; pharmaceutical intervention for dyslexia; and visual training for children with learning disabilities. (DB)


    African Journals Online (AJOL)

    Dr. E. P. Gharoro

    The concept of stem cell research is unarguably one of the most profound concepts of our time and the controversies surrounding it are both complex and difficult to analyse. The issue is hotly debated by all and sundry, among scientists and researchers, in government circles, among people of different faith, even within the ...

  5. Parental Voices and Controversies in Autism (United States)

    Langan, Mary


    Parents of children with autism have played a prominent role in controversies surrounding this condition. Parental voices were critical in challenging the "refrigerator mother" theory and more recently have attracted public attention for claims that autism may be caused by childhood vaccinations and that "unorthodox biomedical" treatments may…

  6. Federal Judge Orders Showing of Controversial Film. (United States)

    Flygare, Thomas J.


    Reviews a recent court decision in Nebraska regarding the cancellation of a controversial film on the University of Nebraska campus. The film was cancelled after a state senator threatened to close the theater if the movie was shown. The lawsuit alleged the university violated the First Amendment in cancelling the film; the judge ruled for the…

  7. Apraxia of Speech: Concepts and Controversies (United States)

    Ziegler, Wolfram; Aichert, Ingrid; Staiger, Anja


    Purpose: This article was written as an editorial to a collection of original articles on apraxia of speech (AOS) in which some of the more recent advancements in the understanding of this syndrome are discussed. It covers controversial issues concerning the theoretical foundations of AOS. Our approach was motivated by a change of perspective on…

  8. Debating Diversity: Ethics and Controversial Public Issues (United States)

    Darr, Christopher R.


    Courses: Ethics, Organizational Communication, Political Communication. Objectives: After completing this unit activity, students should be able to (1) apply multiple ethical perspectives to real-world diversity issues in a debate format, and (2) explain the role of informational and social category diversity in current controversies.

  9. The Saga of the HIV Controversy

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 5. The Saga of the HIV Controversy - Nobel Prize in Physiology or Medicine - 2008. Udaykumar Ranga. General ... Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India.

  10. Teaching Controversial Issues in Social Studies. (United States)

    Guyton, Edith M.; Hoffman, Alan J.

    The design of a methods course offered at Georgia State University to prepare social studies teachers for dealing with controversial issues in the middle school or secondary social studies classroom is presented. The course focuses on identification, selection, an analysis of an issue as well as the requirement that the student develop some method…

  11. Atomic weight versus atomic mass controversy

    International Nuclear Information System (INIS)

    Holden, N.E.


    A problem for the Atomic Weights Commission for the past decade has been the controversial battle over the names ''atomic weight'' and ''atomic mass''. The Commission has considered the arguments on both sides over the years and it appears that this meeting will see more of the same discussion taking place. In this paper, I review the situation and offer some alternatives

  12. Controversies in Pediatric Sports Medicine (Commentary). (United States)

    Dyment, Paul G.


    Discusses controversial issues that have arisen in children's sports, including infant exercise programs, trampolines, amenorrhea in the adolescent athlete, coed contact sports, and sport participation by children with Down Syndrome. Policy statements are included from the American Academy of Pediatrics. (JD)

  13. The Saga of the HIV Controversy

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 5. The Saga of the HIV Controversy - Nobel Prize in Physiology or Medicine - 2008. Udaykumar Ranga. General Article Volume 14 Issue 5 May 2009 pp 472-498. Fulltext. Click here to view fulltext PDF. Permanent link:

  14. Disturbing pasts: Memories, controversies and creativity

    Directory of Open Access Journals (Sweden)

    Leon Wainwright


    Full Text Available This themed issue of the Open Arts Journal, ‘Disturbing pasts: Memories, controversies and creativity’, brings together a range of artists, curators, policy-makers and academics from around the world, who explore creative engagements with controversial and traumatic pasts in art practice, curating and museums. The material is presented in three parts: ‘Difficult Pasts and Public Space’ (writings on historical issues and museums, ‘Visual Investigations’ (artists’ statements and criticism, and ‘Collaborations’ (visual analysis and artist-scholar pairings of writings and original artworks. This collection was developed through a two-year international research project led by Leon Wainwright, which involved three consortia of researchers from universities throughout Europe, and focused on a major public event at the Museum of Ethnology Vienna/ Weltmuseum, Wien (November 2011. The project is funded by HERA (Humanities in the European Research Area, the European Science Foundation.

  15. Epistemic Authority and Genuine Ethical Controversies. (United States)

    Roberts, Adam James


    In 'Professional Hubris and its Consequences', Eric Vogelstein claims that 'that there are no good arguments in favor of professional organizations taking genuinely controversial positions on issues of professional ethics'. In this response, I defend two arguments in favour of organisations taking such positions: that their stance-taking may lead to better public policy, and that it may lead to better practice by medical professionals. If either of those defences succeeds, then Vogelstein's easy path to his conclusion - that professional organisations should not take such stances - is blocked. He or others must instead look to establish that the reasons against stance-taking on genuine ethical controversies are more compelling than those for it: plausibly a more challenging task. © 2017 John Wiley & Sons Ltd.

  16. History of the Belgian nuclear power controversy

    International Nuclear Information System (INIS)

    Laes, E.


    Partly because nuclear energy technology continues to provoke profound controversy, the Flemish institute for technology assessment (viWTA) took the initiative to order a study aimed at mapping out the historical dynamics of the societal debate on nuclear energy. This study was carried out by the Belgian Nuclear Research Centre (SCK-CEN, under the research programme PISA) together with the Free university of Brussels (VUB, research group MEKO) in 2004. In 2007, the report was updated and published by Acco (Leuven) under the title Kernenergie (on)besproken. This study had three main objectives: 1) to discuss the societal debate on nuclear energy in Belgium in relation to major events (Chernobyl, TMI, etc.); 2) to elucidate the role of social actors in the controversy on both a national and international level and 3) to discuss possible alternatives for a better structuring of the debate in the future, building on existing approaches

  17. The Controversies over Bioenergy in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Andersen, Bente Hessellund


    for processing of biomass for biofuels. The alignment with the private car regime is strong, because biofuel enables continuation of fuel-driven vehicles as dominating transportation mode. Danish farmers see manure as important source for biogas while arguing for reduction of climate impact and nuisances from......Based on the approach of 'arena of development' controversies over bioenergy in the shaping of a Danish climate strategy are analyzed as a contribution to a sustainable transition perspective on bioenergy in industrialized societies with substantial agricultural production. Bioenergy plays...... a prominent role in several Danish climate and energy plans, alongside with wind and solar energy, and energy savings. There are major controversies about targets for bioenergy with respect to acceptable types, sources and amounts of biomass. Strong path dependency is identified. Energy companies in Denmark...

  18. Understanding Controversies in Urban Climate Change Adaptation

    DEFF Research Database (Denmark)

    Baron, Nina; Petersen, Lars Kjerulf


    This article explores the controversies that exist in urban climate change adaptation and how these controversies influence the role of homeowners in urban adaptation planning. A concrete SUDS project in a housing cooperative in Copenhagen has been used as a case study thereby investigating...... the multiple understandings “Sustainable Urban Drainages System’s” (SUDS). Several different perspectives are identified with regard to what are and what will become the main climate problems in the urban environment as well as what are considered to be the best responses to these problems. Building...... on the actor-network inspired theory of “urban green assemblages” we argue that at least three different assemblages can be identified in urban climate change adaptation. Each assemblage frames problems and responses differently, and thereby assigns different types of roles to homeowners. As climate change...

  19. Datasprints as a method for Controversy Mapping

    DEFF Research Database (Denmark)

    Jensen, Torben Elgaard; Munk, Anders Kristian; Bach, Daniel


    A datasprint is an intensive 3-5 day workshop that brings together humanistic researchers, data experts, and stakeholders from a selected field. Together, the participants visualize and analyse a collection of data sets, which have been prepared before the datasprint. In the beginning of a datasp......A datasprint is an intensive 3-5 day workshop that brings together humanistic researchers, data experts, and stakeholders from a selected field. Together, the participants visualize and analyse a collection of data sets, which have been prepared before the datasprint. In the beginning...... collaboration between the partners. Since 2015, DIGHUMLAB has sponsored a special interest group in controversy mapping. Datasprints have proved to be a very productive format for controversy making and for creating dialogue and joint projects between humanistic researchers....

  20. Metabolic effects of resveratrol: addressing the controversies. (United States)

    Bitterman, Jacob L; Chung, Jay H


    Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.

  1. Controversies Concerning Theological Language: Cognitivity and Revelation

    Directory of Open Access Journals (Sweden)

    Mindaugas Briedis


    Full Text Available Theological language as a problem under research is especially a controversial one. The question of language enerpsrise is crucial if we are willing to concider theology as a rational and/or critical discipline despite its „object“ or „religious substance“ which can be defined as irrational in the sense of divine mistery. The reflection of a specific referential system which is constituted by theological propositions uncovers peculiar logic of theological language which in turn is always in correlation with basic shifts in philosophy. The paper questions this mutuality as well as presents several characteristic controversies in contemporary theology, particularly in the protestant one. After these goals are achieved, it is possible to formulate concluding  ideas about the problem of cognitive value of revelation, and, on the other hand, about the influence of concrete forms of knowledge (modern ontology for the structures of faith. 

  2. Climatic change science, experience and controversies

    International Nuclear Information System (INIS)

    Le Treut, H.; Van Ypersele, J.P.; Hallegatte, St.; Hourcade, J.Ch.


    The international scientific community, gathered in the framework of the inter-governmental group for climate evolution (Giec), has confirmed the influence of human activities on climate and on the global warming. However, this diagnosis is sometimes questioned in the press. This book, published by the institute of sustainable development, gathers a series of articles written by scientists who make comments on the last Giec reports and who outline the knowledge gained, the remaining uncertainties and the controversies. (J.S.)

  3. Pertussis and Rotavirus Vaccines - Controversies and Solutions. (United States)

    Dash, Nabaneeta; Verma, Sanjay


    Pertussis and rotavirus vaccines have been the subject of several controversies over the years. In this paper the authors discuss facts and myths behind these controversies and also suggest solutions to overcome some limitations of these vaccines. The whole-cell pertussis vaccine (wPV) came into disrepute due to the associated adverse reactions, resulting in its replacement by acellular pertussis vaccine (aPV) in industrialized nations in 1990s. Although wPV is known to have more side effects; but they are usually minor. Whole-cell pertussis containing vaccine is being used safely in the National Immunization programme in India from many years. Another controversy erupted during 2009-2010, when there were reports of resurgence of pertussis cases among adolescents and adults, from developed nations. Present literature review raises doubts about long term protection offered by aPV, when compared with wPV. In spite of prevailing controversy, acellular pertussis containing vaccines should be acceptable, if timely delivery of primary and booster doses is ensured; including vaccination of adolescents and pregnant women. Initial rotavirus vaccine was withdrawn from the market because of increased risk of intussusception. Although three new generation rotavirus vaccines are currently available for use in India, but doubts about their efficacy, long term protection and safety still exists. Present literature review found them to be safe and moderately efficacious because of reasonable good cross protection. Even a moderately efficacious vaccine like rotavirus vaccine could significantly improve the outcome if disease burden is high. Therefore, it is being included in National Immunization Programme of India.

  4. Congenital bronchopulmonary foregut malformations: concepts and controversies

    International Nuclear Information System (INIS)

    Newman, Beverley


    This article addresses the scope, etiology, important associations and imaging features of congenital bronchopulmonary foregut malformations. Etiologic concepts, including airway obstruction and vascular anomalies, are highlighted. Technical imaging advances, especially CT and MR, have greatly enhanced our diagnostic abilities in evaluating these lesions; however, thorough and careful assessment of all aspects of the malformation is still necessary. Several specific lesions are discussed in more detail, particularly regarding controversial issues in classification, understanding, imaging and management. (orig.)

  5. Congenital bronchopulmonary foregut malformations: concepts and controversies

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Beverley [University of Pittsburgh School of Medicine and Children' s Hospital of Pittsburgh, Pittsburgh, PA (United States)


    This article addresses the scope, etiology, important associations and imaging features of congenital bronchopulmonary foregut malformations. Etiologic concepts, including airway obstruction and vascular anomalies, are highlighted. Technical imaging advances, especially CT and MR, have greatly enhanced our diagnostic abilities in evaluating these lesions; however, thorough and careful assessment of all aspects of the malformation is still necessary. Several specific lesions are discussed in more detail, particularly regarding controversial issues in classification, understanding, imaging and management. (orig.)

  6. Facts, myths, and controversies in vascular dementia. (United States)

    Román, Gustavo C


    Significant progress in the field of VaD resulted from publication of the NINIDS-AIREN Diagnostic Criteria for VaD (G.C. Roman, T.K. Tatemichi, T. Erkinjuntti, et al., Vascular dementia (VaD): diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43 (1993) 250-260). Epidemiological studies confirmed the importance of VaD as the second most common cause of dementia in the elderly, representing 15-20% of all cases of dementia. In Europe and North America, Alzheimer's disease (AD) predominates over VaD in a 2:1 ratio; in contrast, in Japan and China VaD accounts for almost 50% of all dementias. Case-control studies have identified risk factors for VaD including ageing, hypertension, diabetes mellitus, hyperlipidemia, recurrent stroke, cardiac disease, smoking, sleep apnea, and more recently, hyperhomocysteinemia, among others. Hypertension treatment may prevent VaD and AD. This finding has enormous importance from the Public Health viewpoint to decrease the future number of patients with dementia in the elderly. Along with advances in the field of VaD came a number of controversies and damaging misconceptions and myths. Myth no. 1--Vascular dementia is a non-entity: The false idea that VaD does not exist is particularly destructive because it creates the perspective that VaD is unworthy of study or research. A condition that either does not exist or represents only a minute proportion of all cases of dementia in the elderly, lacks public health relevance and becomes a low priority for research by funding agencies and industry. In fact, vascular brain lesions are the commonest and most important component of dementia in the elderly. Myth no. 2--Vascular dementia is so difficult to diagnose that only experts can recognize and identify it accurately: VaD does exist and the diagnosis of post-stroke VaD, in particular is straightforward. Most cases fulfill NINDS-AIREN criteria for probable VaD; i.e., (1) there is acute onset

  7. Controversies in faith and health care. (United States)

    Tomkins, Andrew; Duff, Jean; Fitzgibbon, Atallah; Karam, Azza; Mills, Edward J; Munnings, Keith; Smith, Sally; Seshadri, Shreelata Rao; Steinberg, Avraham; Vitillo, Robert; Yugi, Philemon


    Differences in religious faith-based viewpoints (controversies) on the sanctity of human life, acceptable behaviour, health-care technologies and health-care services contribute to the widespread variations in health care worldwide. Faith-linked controversies include family planning, child protection (especially child marriage, female genital mutilation, and immunisation), stigma and harm reduction, violence against women, sexual and reproductive health and HIV, gender, end-of-life issues, and faith activities including prayer. Buddhism, Christianity, Hinduism, Islam, Judaism, and traditional beliefs have similarities and differences in their viewpoints. Improved understanding by health-care providers of the heterogeneity of viewpoints, both within and between faiths, and their effect on health care is important for clinical medicine, public-health programmes, and health-care policy. Increased appreciation in faith leaders of the effect of their teachings on health care is also crucial. This Series paper outlines some faith-related controversies, describes how they influence health-care provision and uptake, and identifies opportunities for research and increased interaction between faith leaders and health-care providers to improve health care. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Current controversies in shock and resuscitation. (United States)

    Orlinsky, M; Shoemaker, W; Reis, E D; Kerstein, M D


    Many controversies and uncertainties surround resuscitation of hemorrhagic shock caused by vascular trauma. Whereas the basic pathophysiology is better understood, much remains to be learned about the many immunologic cascades that lead to problems beyond those of initial fluid resuscitation or operative hemostasis. Fluid therapy is on the verge of significant advances with substitute oxygen carriers, yet surgeons are still beset with questions of how much and what type of initial fluid to provide. Finally, the parameters chosen to guide therapy and the methods used to monitor patients present other interesting issues.

  9. Lessons learnt from the organ retention controversy

    International Nuclear Information System (INIS)

    Madden, D.


    This paper examines the lessons to be learnt from the organ retention controversy in the Republic of Ireland. The paper emphasises the importance of good communication between clinicians and families of deceased persons and a move away from a medical culture based on paternalism to a partnership approach between clinicians and patients based on mutual trust and understanding. A model of authorisation rather than consent is proposed as the way forward for dealing with the difficult and traumatic experience of asking families for permission to carry out a post mortem examination on their deceased child. (authors)

  10. Dissociative identity disorder: a controversial diagnosis. (United States)

    Gillig, Paulette Marie


    A brief description of the controversies surrounding the diagnosis of dissociative identity disorder is presented, followed by a discussion of the proposed similarities and differences between dissociative identity disorder and borderline personality disorder. The phenomenon of autohypnosis in the context of early childhood sexual trauma and disordered attachment is discussed, as is the meaning of alters or alternate personalities. The author describes recent neurosciences research that may relate the symptoms of dissociative identity disorder to demonstrable disordered attention and memory processes. A clinical description of a typical patient presentation is included, plus some recommendations for approaches to treatment.

  11. Controversies Concerning the Canadian Not Criminally Responsible Reform Act. (United States)

    Lacroix, Robert; O'Shaughnessy, Roy; McNiel, Dale E; Binder, Renée L


    In Canada, individuals found not criminally responsible on account of mental disorder are subject to the disposition recommendations of the Provincial or Territorial Review Board of the jurisdiction where the offense was committed. Bill C-14, known as "The Not Criminally Responsible Reform Act" made changes to the postverdict disposition process of these individuals. This legislation was consistent with a broader "tough-on-crime" agenda of the previous federal government. The legislative changes codify that Review Boards take public safety as the "paramount consideration" in making their recommendations. The legislation also creates a new "high-risk" category for certain offenders and imposes limitations on their liberty. Further, Bill C-14 seeks to enhance victim involvement in the disposition process. The passage of this legislation has generated significant controversy in the medical and legal fields. Critics have stated that there is an absence of empirical evidence on which to base the amendments, that the legislation was an overreaction to high-profile cases, and that Bill C-14 is in questionable compliance with the Canadian Charter of Rights and Freedoms. In this review, we explore the potential catalysts involved in the creation of Bill C-14, the controversy surrounding the legislation, and the potential future impact on practicing forensic psychiatrists and on the forensic mental health system in Canada. © 2017 American Academy of Psychiatry and the Law.

  12. Teaching the Philosophical Interpretations of Quantum Mechanics and Quantum Chemistry through Controversies (United States)

    Garritz, Andoni


    This study has the key premise of teaching history and philosophy of physical sciences to illustrate how controversies and rivalries among scientists play a key role in the progress of science and why scientific development is not only founded on the accumulation of experimental data. The author is a defender of teachers who consider…

  13. Challenges in modelling homogeneous catalysis: new answers from ab initio molecular dynamics to the controversy over the Wacker process. (United States)

    Stirling, András; Nair, Nisanth N; Lledós, Agustí; Ujaque, Gregori


    We present here a review of the mechanistic studies of the Wacker process stressing the long controversy about the key reaction steps. We give an overview of the previous experimental and theoretical studies on the topic. Then we describe the importance of the most recent Ab Initio Molecular Dynamics (AIMD) calculations in modelling organometallic reactivity in water. As a prototypical example of homogeneous catalytic reactions, the Wacker process poses serious challenges to modelling. The adequate description of the multiple role of the water solvent is very difficult by using static quantum chemical approaches including cluster and continuum solvent models. In contrast, such reaction systems are suitable for AIMD, and by combining with rare event sampling techniques, the method provides reaction mechanisms and the corresponding free energy profiles. The review also highlights how AIMD has helped to obtain a novel understanding of the mechanism and kinetics of the Wacker process.

  14. Present state of the controversy about the grain boundary relaxation

    International Nuclear Information System (INIS)

    Povolo, F.; Molinas, B.J.


    An analysis of the internal friction produced by grain boundary relaxation in metals, alloys and ceramics is presented. The different interpretations given in the literature to relaxation phenomena occurring at temperatures above about half the melting point which include the influence of grain boundaries and their interaction with solutes and precipitates are discussed in detail. A complete set of the experimental data disposable in this field since 1972 until today is reviewed. Finally, some recent experiments are discussed and new ones are suggested. They might solve the actual controversy about the real origin of the relaxation phenomena observed. If this is the case, a considerable amount of information already published can be taken into account with a good degree of confidence. This information contributes to the description of the structure and behaviour of grain boundaries, both being important topics for materials science. (author). 119 refs, 21 figs, 1 tab

  15. Thermal conductance of nanofluids: is the controversy over?

    International Nuclear Information System (INIS)

    Keblinski, Pawel; Prasher, Ravi; Eapen, Jacob


    Over the last decade nanofluids (colloidal suspensions of solid nanoparticles) sparked excitement as well as controversy. In particular, a number of researches reported dramatic increases of thermal conductivity with small nanoparticle loading, while others showed moderate increases consistent with the effective medium theories on well-dispersed conductive spheres. Accordingly, the mechanism of thermal conductivity enhancement is a hotly debated topic. We present a critical analysis of the experimental data in terms of the potential mechanisms and show that, by accounting for linear particle aggregation, the well established effective medium theories for composite materials are capable of explaining the vast majority of the reported data without resorting to novel mechanisms such as Brownian motion induced nanoconvection, liquid layering at the interface, or near-field radiation. However, particle aggregation required to significantly enhance thermal conductivity, also increases fluid viscosity rendering the benefit of nanofluids to flow based cooling applications questionable.

  16. Autoimmune diseases and infections: controversial issues. (United States)

    Baio, P; Brucato, A; Buskila, D; Gershwin, M E; Giacomazzi, D; Lopez, L R; Luzzati, R; Matsuura, E; Selmi, C; Sarzi-Puttini, P; Atzeni, F


    The etiology and pathogenesis of certain types of disease remain controversial and stand like a bridge that crosses infectious, autoimmune and autoinflammatory pathways. Infection, for example, may initiate a disease, although it is the genetic regulation in the host, the interplay between virus or bacteria persistence and autoimmunity that produces the later phases of disease, the antigenic determinants responsible for inducing autoimmune disease, and the pathogenetic effector mechanisms. Infections agents cause pericarditis, but in 85% of cases it is "idiopathic". It has also been shown that persistent Clamydia pneumoniae, Porphyromonas gingivalis, and Helicobacter pylori infections cause host immunity and promote atherogenesis. A number of infectious agents have been suggested as potential triggers for primary biliary cirrhosis. Infections and vaccinations have also been linked to the pathogenesis of fibromyalgia syndrome, a common, chronic syndrome of widespread pain. Many factors are also responsible for fever of unknown origin such as: infections, autoimmunity disease, etc. However, it is difficult to determine a direct correlation between the infections agents in such a large group of diseases. The aim of this review is to analyze some of the controversies about the role of infections in autoimmune diseases.

  17. Controversial Issues in Thyroid Cancer Management. (United States)

    Tuttle, R Michael


    The lack of prospective randomized clinical trials for most management topics in differentiated thyroid cancer force us to make management recommendations based on retrospective observational data which is often incomplete, subject to selection bias, and conflicting. Therefore, it is not surprising that many aspects of thyroid cancer management remain controversial and not well defined. This review will examine the controversies surrounding three important topics in thyroid cancer management: (1) the option of thyroid lobectomy as initial therapy for thyroid cancer, (2) the proper use of preoperative neck imaging to optimize the completeness of the initial surgical procedure, and (3) the selective use RAI therapy as remnant ablation, adjuvant treatment or treatment of known persistent/recurrent disease. As thyroid cancer management moves toward a much more risk adapted approach to personalized management recommendations, clinicians and patients must balance the risks and benefits of the potential management options to arrive at a management plan that is optimized based on both patient preferences/values and the philosophy/experience of the local disease management team. Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  18. Evolutionary psychology. Controversies, questions, prospects, and limitations. (United States)

    Confer, Jaime C; Easton, Judith A; Fleischman, Diana S; Goetz, Cari D; Lewis, David M G; Perilloux, Carin; Buss, David M


    Evolutionary psychology has emerged over the past 15 years as a major theoretical perspective, generating an increasing volume of empirical studies and assuming a larger presence within psychological science. At the same time, it has generated critiques and remains controversial among some psychologists. Some of the controversy stems from hypotheses that go against traditional psychological theories; some from empirical findings that may have disturbing implications; some from misunderstandings about the logic of evolutionary psychology; and some from reasonable scientific concerns about its underlying framework. This article identifies some of the most common concerns and attempts to elucidate evolutionary psychology's stance pertaining to them. These include issues of testability and falsifiability; the domain specificity versus domain generality of psychological mechanisms; the role of novel environments as they interact with evolved psychological circuits; the role of genes in the conceptual structure of evolutionary psychology; the roles of learning, socialization, and culture in evolutionary psychology; and the practical value of applied evolutionary psychology. The article concludes with a discussion of the limitations of current evolutionary psychology. 2009 APA, all rights reserved.

  19. Previously unknown organomagnesium compounds in astrochemical context


    Ruf, Alexander


    We describe the detection of dihydroxymagnesium carboxylates (CHOMg) in astrochemical context. CHOMg was detected in meteorites via ultrahigh-resolving chemical analytics and represents a novel, previously unreported chemical class. Thus, chemical stability was probed via quantum chemical computations, in combination with experimental fragmentation techniques. Results propose the putative formation of green-chemical OH-Grignard-type molecules and triggered fundamental questions within chemica...

  20. Highlights from the previous volumes (United States)

    Vergini Eduardo, G.; Pan, Y.; al., Vardi R. et; al., Akkermans Eric et; et al.


    Semiclassical propagation up to the Heisenberg time Superconductivity and magnetic order in the half-Heusler compound ErPdBi An experimental evidence-based computational paradigm for new logic-gates in neuronal activity Universality in the symmetric exclusion process and diffusive systems

  1. Science motivation by discussion and controversy (SMDC) model (United States)

    Izadi, Dina; Mora Ley, César Eduardo; Ramírez Díaz, Mario Humberto


    Succeeding theories and empirical investigations have often been built over conceptual understanding to develop talent education. Opportunities provided by society are crucial at every point in the talent-development process. Abilities differ and can vary among boys and girls. Although they have some responsibility for their own growth and development, the educational system and psychosocial variables influence on the successful development of high levels of education. This research explores students’ attitudes to science education to establish why many disengage with the subject in class and what can be done to reverse this trend to produce unimaginable scientific and practical benefits to society. The control group is students from several schools with traditional education in Iran and the experimental group is teams who have taken part in several activities such as national and international tournaments (2005-2013). This research has two parts: 1—how innovation in teaching and 2—discussion and controversy in class can improve science education and cause motivation. The average scores are divided into 5 ranges in both experimental and traditional groups. As shown by Spearman’s correlation rank (ρ) the difference between boys’ and girls’ average scores is about (2.71) in the control group but it has decreased to (0.29) in the experimental group. The main point of discussion is on problems in class which advance a set of interrelated scientific arguments for outstanding achievement.

  2. Element 74, the Wolfram Versus Tungsten Controversy

    Energy Technology Data Exchange (ETDEWEB)



    Two and a quarter centuries ago, a heavy mineral ore was found which was thought to contain a new chemical element called heavy stone (or tungsten in Swedish). A few years later, the metal was separated from its oxide and the new element (Z=74) was called wolfram. Over the years since that time, both the names wolfram and tungsten were attached to this element in various countries. Sixty years ago, IUPAC chose wolfram as the official name for the element. A few years later, under pressure from the press in the USA, the alternative name tungsten was also allowed by IUPAC. Now the original, official name 'wolfram' has been deleted by IUPAC as one of the two alternate names for the element. The history of this controversy is described here.

  3. Diabetes mellitus and tuberculosis facts and controversies (United States)


    Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues. A bidirectional association between them has been demonstrated by many researchers. The link of DM and TB is more prominent in developing countries where TB is endemic and the burden of diabetes mellitus is increasing. The association between diabetes and tuberculosis may be the next challenge for global tuberculosis control worldwide. Proper planning and collaboration are necessary to reduce the dual burden of diabetes and TB. One model similar to the TB-HIV program for prevention, screening and treatment of both diseases can be the best approach. In this paper, we review existing data and discuss the matters of controversy that would be helpful for determining research priorities in different countries. PMID:24360398

  4. Some remarks about the 'controversial discussions'. (United States)

    Hayman, A


    In 1943-44, the British Psycho-Analytical Society held the 'Controversial Discussions' in an attempt to resolve various disagreements then current in the theory, practice and teaching of psychoanalysis. This paper selects and assesses in some detail some of the arguments that emerged around the concepts of 'unconscious phantasy' and 'unconscious conflict'. Inter alia, they included arguments about assumed early events, about ways of interpreting and assessing evidence, about modes and different levels of conceptualisation, about interpretations of Freud and about changes in psychoanalyic theory. Attempts to achieve mutual understanding existed side by side with total and sometimes rancorous disagreement. Attention is given to sometimes irresolvable communicative and conceptual difficulties that arose and still arise, from differences in meaning that different psychoanalytic thinkers assigned and still assign to each of the two conceptual terms, 'unconscious phantasy' and 'unconscious conflict'.

  5. The controversial universality of individual human rights

    Directory of Open Access Journals (Sweden)

    Friedrich Graf


    Full Text Available Human rights is currently a very relevant but also very controversial issue in international politics in the aftermath of some of the events that occurred during the twentieth century. In this article, the author puts the present issues in perspective by initiating the discussion with a look at aspects of the historical development of the concept of human rights. He then moves on to take a closer look at how the concept of human rights feature� and function in the Christian religion and follows that up with an overview of how human rights are perceived and are operative in the religion of Islam. The article concludes with a focus on inter-cultural discourse.�

  6. The Breivik controversy: politics, terrorism and psychiatry. (United States)

    Tietze, Tad


    To examine and analyse the controversy over psychiatric aspects of the case of Norwegian far right mass murderer Anders Behring Breivik. Because of a basic acceptance of methodological individualism and scientific positivism, mainstream psychiatry is currently ill suited to being broadly applied to the spheres of politics and political violence. Rather than jettison psychiatric insights in such cases, the choices facing the profession are either to accept the narrowness of its utility or to work towards a theoretical framework that sees the individual psyche as socially embedded rather than as socially constitutive, and psychiatric science itself as socially constructed and hence inescapably value-laden. © The Royal Australian and New Zealand College of Psychiatrists 2014.

  7. Acute Kidney Injury: Diagnostic Approaches and Controversies (United States)

    Makris, Konstantinos; Spanou, Loukia


    Acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality. In the last ten years a large number of publications have highlighted the limitations of traditional approaches and the inadequacies of conventional biomarkers to diagnose and monitor renal insufficiency in the acute setting. A great effort was directed not only to the discovery and validation of new biomarkers aimed to detect AKI more accurately but also to standardise the definition of AKI. Despite the advances in both areas, biomarkers have not yet entered into routine clinical practice and the definition of this syndrome has many areas of uncertainty. This review will discuss the controversies in diagnosis and the potential of novel biomarkers to improve the definition of the syndrome. PMID:28167845

  8. The Cartoon Controversy: Offence, Identity, Oppression?

    DEFF Research Database (Denmark)

    Lægaard, Sune


    If the publication of twelve drawings of the Prophet Mohammad in the Danish newspaper Jyllands-Posten, which sparked the ‘cartoon controversy', was wrong, why might this be the case? The article considers four arguments advanced in relation to the quite similar Rushdie affair for judging...... such publications to be wrong, and asks whether they provide plausible moral reasons against such publications, and whether they justify legal restrictions on freedom of speech. The arguments concern: (a) the consistent extension of group defamation legislation to cover Muslims; (b) offence to religious...... for judging the kind of publications under consideration to be morally wrong or suitable objects for legal restrictions. The argument from oppression is different, however, in pointing to different kinds of factors, but its applicability is limited both by a number of conditions for when oppression provides...

  9. Ibuprofen in paediatrics: pharmacology, prescribing and controversies. (United States)

    Moriarty, Camilla; Carroll, Will


    Ibuprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory drug. The oral formulation is widely used in paediatric practice and after paracetamol it is one of the most common drugs prescribed for children in hospital. The treatment of fever with antipyretics such as ibuprofen is controversial as fever is the normal response of the body to infection and unless the child becomes distressed or symptomatic, fever alone should not be routinely treated. Combined treatment with paracetamol and ibuprofen is commonly undertaken but almost certainly is not helpful. This article aims to describe the indications and mode of action of the drug, outline its pharmacokinetics and highlight the important key messages regarding its use in clinical practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

  10. The controversy on chronic cerebrospinal venous insufficiency

    Directory of Open Access Journals (Sweden)

    Paolo Zamboni


    Full Text Available The objective of this review is to analyze the actual scientific controversy on chronic cerebrospinal venous insufficiency (CCSVI and its association with both neurodegenerative disorders and multiple sclerosis (MS. We revised all published studies on prevalence of CCSVI in MS patients, including ultrasound and catheter venography series. Furthermore, we take into consideration other publications dealing with the pathophysiologic consequences of CCSVI in the brain, as well as ecent data characterizing the pathology of the venous wall in course of CCSVI. Finally, safety and pilot data on effectiveness of endovascular CCSVI treatment were further updated. Studies of prevalence show a big variability in prevalence of CCSVI in MS patients assessed by established ultrasonographic criteria. This could be related to high operator dependency of ultrasound. However, 12 studies, by the means of more objective catheter venography, show a prevalence >90% of CCSVI in MS. Global hypo-hypoperfusion of the brain, and reduced cerebral spinal fluid dynamics in MS was shown to be related to CCSVI. Postmortem studies and histology corroborate the 2009 International Union of Phlebology (UIP Consensus decision to insert CCSVI among venous malformations. Finally, safety of balloon angioplasty of the extracranial veins was certainly demonstrated, while prospective data on the potential effectiveness of endovascular treatment of CCSVI support to increase the level of evidence by proceeding with a randomized control trial (RCT. Taking into account the current epidemiological data, including studies on catheter venography, the autoptic findings, and the relationship between CCSVI and both hypo-perfusion and cerebro-spinal fluid flow, we conclude that CCSVI can be definitively inserted among the medical entities. Research is still inconclusive in elucidating the CCSVI role in the pathogenesis of neurological disorders. The controversy between the vascular and the

  11. Cancer stem cells in lung cancer: Evidence and controversies (United States)

    ALAMGEER, Muhammad; PEACOCK, Craig D.; MATSUI, William; GANJU, Vinod; WATKINS, D. Neil


    The cancer stem cell (CSC) model is based on a myriad of experimental and clinical observations suggesting that the malignant phenotype is sustained by a subset of cells characterized by the capacity for self-renewal, differentiation and innate resistance to chemotherapy and radiation. CSC may be responsible for disease recurrence after definitive therapy and may therefore be functionally synonymous with minimal residual disease. Similar to other solid tumours, several putative surface markers for lung CSC have been identified, including CD133 and CD44. In addition, expression and/or activity of the cytoplasmic enzyme aldehyde dehydrogenase ALDH and capacity of cells to exclude membrane permeable dyes (known as the ‘side population’) correlate with stem-like function in vitro and in vivo. Embryonic stem cell pathways such as Hedgehog, Notch and WNT may also be active in lung cancers stem cells and therefore may be therapeutically targetable for maintenance therapy in patients achieving a complete response to surgery, radiotherapy or chemo-therapy. This paper will review the evidence regarding the existence and function of lung CSC in the context of the experimental and clinical evidence and discuss some ongoing controversies regarding this model. PMID:23586700

  12. Dialogs on the Yucca Mountain controversy. Special report No. 10

    International Nuclear Information System (INIS)

    Schluter, C.M.; Szymanski, J.S.


    In an attempt to resolve the controversial issue of tectonic and hydrologic stability of the Yucca Mountain region, the National Academy of Sciences established a Panel on Coupled Hydrologic/Tectonic/HydrothermaI Systems. The Panel has recently released it's findings in a report entitled Ground Water at Yucca Mountain: How High Can It Rise? The representation of data and the scientific validity of this report was the subject of comprehensive evaluations and reviews which has led to correspondence between Dr. Charles Archarnbeau and Dr. Frank Press, the President of the National Academy of Sciences. All such correspondence prior to April 9, 1993 is covered by TRAC Special Report No. 5, open-quotes Dialogs on the Yucca Mountain Controversy.close quotes The present report represents a continuation of the dialog between Dr. Archambeau and Dr. Press; specifically the letter from Dr. Press to Dr. Archambeau dated April 9, 1993 and Archambeau's response to Press, dated August 19, 1993. In addition to the correspondence between Press and Archambeau, a series of recent reports by other investigators, referred to in the correspondence from Archambeau, are included in this report and document new data and inferences of importance for resolution of the question of suitability of the Yucca Mountain site as a high level nuclear waste repository. These reports also demonstrate that other scientists, not previously associated with the government's program at Yucca Mountain or the National Academy review of an aspect of that program, have arrived at conclusions that are different than those stated by the Academy review and DOE program scientists

  13. Phytosynthesis of nanoparticles: concept, controversy and application (United States)

    Husen, Azamal; Siddiqi, Khwaja Salahuddin


    Nanotechnology is an exciting and powerful discipline of science; the altered properties of which have offered many new and profitable products and applications. Agriculture, food and medicine sector industries have been investing more in nanotechnology research. Plants or their extracts provide a biological synthesis route of several metallic nanoparticles which is more eco-friendly and allows a controlled synthesis with well-defined size and shape. The rapid drug delivery in the presence of a carrier is a recent development to treat patients with nanoparticles of certain metals. The engineered nanoparticles are more useful in increasing the crop production, although this issue is still in infancy. This is simply due to the unprecedented and unforeseen health hazard and environmental concern. The well-known metal ions such as zinc, iron and copper are essential constituents of several enzymes found in the human system even though the indiscriminate use of similar other metal nanoparticle in food and medicine without clinical trial is not advisable. This review is intended to describe the novel phytosynthesis of metal and metal oxide nanoparticles with regard to their shape, size, structure and diverse application in almost all fields of medicine, agriculture and technology. We have also emphasized the concept and controversial mechanism of green synthesis of nanoparticles.

  14. Phytosynthesis of nanoparticles: concept, controversy and application. (United States)

    Husen, Azamal; Siddiqi, Khwaja Salahuddin


    Nanotechnology is an exciting and powerful discipline of science; the altered properties of which have offered many new and profitable products and applications. Agriculture, food and medicine sector industries have been investing more in nanotechnology research. Plants or their extracts provide a biological synthesis route of several metallic nanoparticles which is more eco-friendly and allows a controlled synthesis with well-defined size and shape. The rapid drug delivery in the presence of a carrier is a recent development to treat patients with nanoparticles of certain metals. The engineered nanoparticles are more useful in increasing the crop production, although this issue is still in infancy. This is simply due to the unprecedented and unforeseen health hazard and environmental concern. The well-known metal ions such as zinc, iron and copper are essential constituents of several enzymes found in the human system even though the indiscriminate use of similar other metal nanoparticle in food and medicine without clinical trial is not advisable. This review is intended to describe the novel phytosynthesis of metal and metal oxide nanoparticles with regard to their shape, size, structure and diverse application in almost all fields of medicine, agriculture and technology. We have also emphasized the concept and controversial mechanism of green synthesis of nanoparticles.


    Directory of Open Access Journals (Sweden)



    Full Text Available In the knowledge society, when there is a rapidly evolving information technology, the virtual markets, namely the online transactions, have created the premises emergence and development of new technologies of using of finances, namely virtual coin (Bitcoin. Use of this coin appears as an alternative to traditional currencies, but they are not under the control of no body, are devoid of inflation and maintain the anonymity of users. Following the evolution of this new type of coin, we proposed in this paper to present some general aspects of this coin focusing on global controversies on using Bitcoin. We have reviewed several myths that have arisen with the development and penetration of its on market and because it is a volatile coin can generate huge gains but and huge losses, we have studied fluctuation and implications for users and investors and the attraction of the drug dealers and criminals for using virtual currency, Bitcoin. At the end of the paper, based on the analysis we have tried to outline the future of this modern payment system. Thus, we found that lately, in that its value has fluctuated strongly, and increased buyer confidence, but appeared and increased cyber attacks, and the fear that if the state has no a role in protecting citizens from fraud, we can assist at the development of financial schemes extremely dangerous. The financial experts believe that if the world banks would jointly solve all the problems, the virtual money will have a real chance of life.

  16. Biliary tract cancers: current concepts and controversies. (United States)

    Leonard, Gregory D; O'Reilly, Eileen M


    Biliary tract cancer, which consists of gall bladder cancer and cholangio-carcinoma, presents many challenges to practising physicians. It is a relatively rare cancer that often causes a diagnostic dilemma, as its presentation may be similar to that of non-malignant conditions. In many cases, histological or cytological confirmation of a cancer diagnosis is not possible preoperatively. The management of this disease is also complex due to a morbid patient population and limited data on the optimal therapeutic approach. Surgery remains the mainstay of treatment, although the extent of resection required is still debated. The role of adjuvant therapy is also controversial, but a combined modality approach appears to be beneficial in patients with a high risk of recurrence, such as those with node positive tumors or positive resection margins. When surgery is not possible, the prognosis of patients with biliary tract cancer is very poor. In unresectable patients, the combination of chemotherapy and radiotherapy can result in a prolonged survival for some patients. In the palliative setting, biliary stenting and other supportive measures can alleviate symptoms and improve survival. Gemcitabine-based combination chemotherapy may also provide successful palliation and has achieved response rates of approximately 30% and a median survival of > 15 months in one study. Ultimately, treatment decisions should be individualised and participation in clinical trials is encouraged. Further progress in the management of biliary tract cancer is anticipated using biological therapies and continued research is essential to discover the optimal treatment for this challenging disease.

  17. Energy controversy: the role of nuclear power

    International Nuclear Information System (INIS)

    Schmidt, F.H.; Bodansky, D.


    The objective of the paper presented is to show that nuclear fission power is the best, and maybe the only, alternative source of energy. It is written for a wide range of readers, including non-scientists and scientists who are not particularly informed on the issues involved. The first question considered concerns man's need for energy; it is concluded that conservation measures alone cannot suffice. Next, the earth's energy sources are examined, and the extent of each is estimated in the simple context of the length of time it could last at present use rates. Only nuclear fission, nuclear fusion, and solar energy can provide for future time scales commensurate with man's historic past, while avoiding the possibility of catastrophic social upheaval. Fusion and solar energy are rejected on technological grounds because the world energy problem is so pressing that one cannot gamble on hopes for future technological breakthroughs. Thus, only nuclear fission meets the twin criteria of technological feasibility and adequate resource base. Each of the controversial issues surrounding nuclear fission energy is examined in some detail. The conclusion is reached that none is serious, and that nuclear fission offers by far the best energy source from environmental, economic, longevity, and overall safety standpoints

  18. Iron hypothesis of cardiovascular disease: still controversial. (United States)

    Aursulesei, Viviana; Cozma, A; Krasniqi, A


    Iron hypothesis has been a controversial subject for over 30 years as many studies support its role as a risk factor for cardiovascular disease, while other studies found no evidence to support it. The conflicting results are accounted for by the non-homogeneity of trial design in terms of population inclusion criteria and different endpoints, non-uniform use of parameters for assessing iron role, and incomplete understanding of the mechanisms of action. The nature of iron is dual, being of crucial importance for the human body, but also toxic as "free iron" induces oxidative stress. Under physiological conditions, there are efficient and complex mechanisms against iron-induced oxidative stress, which could be reproduced for creating new, intelligent antioxidants. Iron depletion improves the cardiovascular prognosis only if serum concentration is at the lowest limit of normal ranges. However, low iron levels and the type of dietary iron intake correlate with atherosclerotic cardiovascular disease, influence the ischemic endpoints in the elderly, and exert negative impact on heart failure prognosis. So far, the causal relation and involved mechanisms are not fully elucidated. Iron overload is a difficult and frequent condition, involving the cardiovascular system by specific pathogenic pathways, therefore determining a particular form of restrictive cardiomyopathy and vaso-occlusive arterial damage.

  19. Mendelian controversies: a botanical and historical review. (United States)

    Fairbanks, D J; Rytting, B


    Gregor Mendel was a 19(th) century priest and botanist who developed the fundamental laws of inheritance. The year 2000 marked a century since the rediscovery of those laws and the beginning of genetics. Although Mendel is now recognized as the founder of genetics, significant controversy ensued about his work throughout the 20(th) century. In this paper, we review five of the most contentious issues by looking at the historical record through the lens of current botanical science: (1) Are Mendel's data too good to be true? (2) Is Mendel's description of his experiments fictitious? (3) Did Mendel articulate the laws of inheritance attributed to him? (4) Did Mendel detect but not mention linkage? (5) Did Mendel support or oppose Darwin?A synthesis of botanical and historical evidence supports our conclusions: Mendel did not fabricate his data, his description of his experiments is literal, he articulated the laws of inheritance attributed to him insofar as was possible given the information he had, he did not detect linkage, and he neither strongly supported nor opposed Darwin.

  20. Maxillary reconstruction: Current concepts and controversies

    Directory of Open Access Journals (Sweden)

    Subramania Iyer


    Full Text Available Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. The defects of maxilla apart from affecting the functions of the speech, swallowing and mastication also cause cosmetic disfigurement. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Literature is abundant with a variety of reconstructive methods. The classification systems are also varied, with no universal acceptance of any one of them. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Management of the orbit is also not yet addressed properly. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. This review article discusses the rationale and oncological safety of the reconstructing the maxillary defects, critically analyzes the classification systems, offers the different reconstructive methods and touches upon the controversies in this subject. The management of the retained and exenterated orbit associated with maxillectomy is reviewed. The surgical morbidity, complications and the recent advances in this field are also looked into. An algorithm, based on our experience, is presented.

  1. Advances and controversies in yellow fever vaccination. (United States)

    Jonker, Emile F F; Visser, Leonardus G; Roukens, Anna H


    Ever since its development in 1937, the live-attenuated 17D yellow fever (YF) vaccine has been one of the most effective vaccines available to man. In this review we highlight the major steps in the development of 17D YF vaccine. We discuss the use of neutralizing antibodies as a surrogate marker for protection, and explore the strengths and weaknesses of the current plaque reduction neutralization test (PRNT), a technique developed in the 1960s that continues to be superior to every modern test in both sensitivity and specificity. The neutralizing antibodies demonstrated by the PRNT can be detected for several decades after vaccination, possibly even for the remainder of the recipient's natural life. We review the available evidence on the duration of protection after primary vaccination, a topic that has been the subject of controversy over the last few months. For persons who are immunocompromised due to disease, medication or advancing age, the duration of protection may be shorter: they should always have their vaccine response checked by PRNT. Due to the higher risk of severe adverse events after vaccination with 17D YF in this group, the development of a new, inactivated vaccine will have substantial benefits in this population.

  2. The nuclear energy controversy in Austria

    International Nuclear Information System (INIS)

    Oszuszky, F.; Szeless, A.


    The sociological aspects of the energy issue have become of overwhelming importance in the last few years. As a result, traditional considerations such as the importance of adequate and cheap energy supplies as the basis for growth, and the necessity, in a time of politically uncertain oil supplies, of energy supply security and diversity, have been equalled in importance, and sometimes replaced, by arguments about the social goals to be achieved. Nuclear energy has been selected as the vehicle for a socio-political debate on the controversial issue of the application of large-scale technology. Beyond that it has acquired a symbolic role in what is really an emotional attack on the political systems, economy and culture of present day civilization. It stands for the concentration of power, the centralization of technology and society, and man's dependence on the products of that centralization. Nuclear power is seen as one of the motors of further economic growth and thus an apparent pioneer of the further destruction of our natural and social environment. (author)

  3. Cognitive styles: Controversial issues and research problems

    Directory of Open Access Journals (Sweden)

    Natalia N. Volkova


    Full Text Available The paper presents an analytical review of cognitive styles research, considering the problems of its theory, methodology, measurement and practical applications. Issues concerning the prospects, as well as theoretical and practical relevance of cognitive styles research, are discussed. We examine the main causes leading to researchers’ declining interest to study of cognitive styles, related to theory, methodology, measurement and practical applications. The main problems discussed relate to lack of clear definition and common theoretical framework. Moreover, the number of empirical studies prevails over the one aimed at theoretical generalization of empirical results and findings, and therefore the primacy of empirics appears. We analyze the possible ways of advancing the field, suggested research programs and potential perspectives for future research. We pose questions of the relationship between cognitive styles and other psychological constructs, such as abilities and cognitive strategies. We emphasize the need to develop integrative models of cognitive styles in order to systematize and organize a large number of existing cognitive styles dimensions. The main controversial issues concerning cognitive styles’ stability and value are considered. We suggest that cognitive style is a psychological mean of cognitive tasks solving, based on both situation circumstances and subject’s current cognitive resources. Issues concerning cognitive styles may answer the question on the nature of individual differences and clarify psychological mechanisms of personality-situation interaction. Furthermore, it may serve as a basis for integrated studies at the areas of personality and cognitive psychology.

  4. Phytosynthesis of nanoparticles: concept, controversy and application (United States)


    Nanotechnology is an exciting and powerful discipline of science; the altered properties of which have offered many new and profitable products and applications. Agriculture, food and medicine sector industries have been investing more in nanotechnology research. Plants or their extracts provide a biological synthesis route of several metallic nanoparticles which is more eco-friendly and allows a controlled synthesis with well-defined size and shape. The rapid drug delivery in the presence of a carrier is a recent development to treat patients with nanoparticles of certain metals. The engineered nanoparticles are more useful in increasing the crop production, although this issue is still in infancy. This is simply due to the unprecedented and unforeseen health hazard and environmental concern. The well-known metal ions such as zinc, iron and copper are essential constituents of several enzymes found in the human system even though the indiscriminate use of similar other metal nanoparticle in food and medicine without clinical trial is not advisable. This review is intended to describe the novel phytosynthesis of metal and metal oxide nanoparticles with regard to their shape, size, structure and diverse application in almost all fields of medicine, agriculture and technology. We have also emphasized the concept and controversial mechanism of green synthesis of nanoparticles. PMID:24910577

  5. Cellulite: advances in treatment: facts and controversies. (United States)

    Emanuele, Enzo


    Cellulite is traditionally considered a highly prevalent aesthetic condition in women. From a clinical standpoint, it is characterized by a cottage-cheese-like appearance of the skin, which can be most commonly found in certain areas of the body (eg, thighs, buttocks, and legs). Although cellulite is generally asymptomatic, the more severe stages can be accompanied by the appearance of painful nodules and increased local temperature, which are suggestive of an inflammatory reaction occurring in the dermis and in the underlying subcutaneous adipose tissue. Whether cellulite is a real disease or only a disturbing aesthetic issue is still a matter of controversy. This debate notwithstanding, it seems clear from market trends that there is considerable commercial interest in developing effective strategies aimed at reducing the cottage-cheese-like appearance of cellulite areas. Quite disturbingly, the majority of treatment attempts to date have been conducted in an empirical manner and without the application of rigorous scientific methodology. This is likely due--at least in part--to the lack of major, evidence-based pathophysiological insights into the nature of this condition. More stringent regulatory control is needed over commercial products aiming at improving the appearance of cellulite. © 2013 Elsevier Inc. All rights reserved.

  6. The Controversy over the Buddhas of Bamiyan

    Directory of Open Access Journals (Sweden)

    Pierre Centlivres


    Full Text Available The author analyses a rare case of mirror-outrage that followed the destruction of the Buddhas of Bamiyan. This event brought the Taliban and the international community into opposition in 2001. The article first stresses the intriguing paradigmatic similarities between the destruction of the Buddhas and the destruction of Artemis Temple in 356 BC, when the eradication of a monument, sacred as well as emblematic of a cultural heritage, was perceived as an outrage against piety and beauty. This analogy helps the author emphasize the uncertainty regarding the identification of the victims: were they ‘the people’ in general, abstract deities, or specific communities? The article then elaborates on the argumentation and self-justification presented by the Taliban, and underlies their sense of indignation at a protest coming from ‘Christian’ countries, which they saw as exclusively concerned with saving ‘idols’ but ignorant of the ordeal endured by the Afghans. It finally argues that conflicting visions over the very meaning of ‘cultural heritage’ were at the core of the controversy.

  7. Some controversy about law on private security

    Directory of Open Access Journals (Sweden)

    Stajić Ljubomir


    Full Text Available The Republic of Serbia is one of the last countries that legally regulate the private security sector, which is a new conceptual system of the national security system. Since the law is expected to solve many issues and dilemmas, and bring order to the area, which by some accounts is a very profitable branch of economy. Expectations were that by the end to regulate issues such as: 1 the need for institutionalization of partnership between the public and private sectors for mutual benefit, 2 the need of expressing mutual interest to establish the desired condition of security in the entire society and 3 the need to define the mechanisms and authority to achieve mentioned above. Based on this, legal framework of private security should explicitly provide: 1 a new role of the private sector, 2 communication and data exchange between the public and private sector, 3 mandatory notification about prepared or committed criminal acts on which there is information, 4 cooperation in the tasks of necessarily protected facilities, 4 cooperation in crisis situations including natural disasters, traffic accidents, strikes, sabotage, terrorist attacks, etc., 5 cooperate in the selection and training of staff and 6 cooperation in planning activities and project design of security. This paper presents a critical review of some theoretical and professional controversies in the solutions provided by law, for the purpose of answering whether it is achieving the purpose of passing of such a legal act.

  8. Cold dark matter: Controversies on small scales. (United States)

    Weinberg, David H; Bullock, James S; Governato, Fabio; Kuzio de Naray, Rachel; Peter, Annika H G


    The cold dark matter (CDM) cosmological model has been remarkably successful in explaining cosmic structure over an enormous span of redshift, but it has faced persistent challenges from observations that probe the innermost regions of dark matter halos and the properties of the Milky Way's dwarf galaxy satellites. We review the current observational and theoretical status of these "small-scale controversies." Cosmological simulations that incorporate only gravity and collisionless CDM predict halos with abundant substructure and central densities that are too high to match constraints from galaxy dynamics. The solution could lie in baryonic physics: Recent numerical simulations and analytical models suggest that gravitational potential fluctuations tied to efficient supernova feedback can flatten the central cusps of halos in massive galaxies, and a combination of feedback and low star formation efficiency could explain why most of the dark matter subhalos orbiting the Milky Way do not host visible galaxies. However, it is not clear that this solution can work in the lowest mass galaxies, where discrepancies are observed. Alternatively, the small-scale conflicts could be evidence of more complex physics in the dark sector itself. For example, elastic scattering from strong dark matter self-interactions can alter predicted halo mass profiles, leading to good agreement with observations across a wide range of galaxy mass. Gravitational lensing and dynamical perturbations of tidal streams in the stellar halo provide evidence for an abundant population of low-mass subhalos in accord with CDM predictions. These observational approaches will get more powerful over the next few years.

  9. Addressing the nuclear controversy on university campuses

    International Nuclear Information System (INIS)

    Keyes, G.B.; Poncelet, C.G.


    A strong anti-nuclear sentiment exists on many university campuses. Young minds are eager to adopt causes which purport to reflect new intellectual approaches to social, political and economic issues. Hence, the opposition to nuclear power can be made to seem to be based on: (1) technical study of nuclear plants; (2) concern for the environment; (3) concern for public health and safety; (4) requirements for an improved economic order; and (5) demand for public decision on technical issues. All these elements could attract student and faculty interest and support. To contend with this problem in the USA, Westinghouse Electric Corporation attempted to achieve a dialogue with the student and faculty audiences. The development and results of the programme up to mid-1977 are reported in this paper. A small group of young nuclear engineers was chosen to undergo comprehensive training on the controversy and contemporary campus issues in the States to be visited. Selection and training emphasized the ability of the engineers to relate to the students as their peers. They were encouraged to speak candidly and for themselves. Thus, they did not give the impression of being merely typical corporate spokesmen. The rapport made possible by this approach is very important to the success of such an effort. Invitations to debate before student audiences were issued to leading opposition groups and to the news media. Response by the media has been outstandingly favourable: not only has the coverage been extensive, but it has carried the pro-nuclear arguments to large audiences on a scale and with a credibility not otherwise achievable. The results up to May 1977, in eight States, have been extremely encouraging. Other countries are invited to learn more about the ''Campus America'' programme in order to evaluate whether or not such an approach, with appropriate modification, could prove effective in their own situations. (author)

  10. The Gaia Controversy: AGU'S Chapman Conference (United States)

    Kauffman, Eric G.

    The controversial Gaia Hypothesis of James Lovelock of Coombe Mill, Launceston, Cornwall, U.K., and his colleagues variously contends that throughout Earth history the global biosphere has influenced, even controlled, the physicochemical evolution of Earth's environments (especially oceans and climate) for its own benefit. Since the origin of life, the biosphere has influenced selective pressures on evolution, maintained the Earth in a kind of homeostasis, and thus created an environmental optimum through time, regulated by and for the biosphere. Rarely has a hypothesis immediately sparked such passionate response. There is something in it for everybody, from hard core scientists to philosophers, ultraconservationists, students of world religions, mystics, politicians, and space enthusiasts; they were all there in San Diego, March 7-11, 1988, for the AGU Chapman Conference on Gaia Hypotheses. For 4 days an impressive list of specialists presented and debated the pros and cons of Gaia Hypotheses from diverse perspectives: modern and ancient biology, ecology, biochemistry, the physicochemical systems of the Earth, oceans, and atmosphere, and the evolution of the solar system. Focus was on modern to Pleistocene atmosphere-ocean-Earth systems, case histories of their interaction with the biosphere, and relatively simple models drawn from these observations and projected back through time. Equivalent studies on the geological and paleobiological history of the Earth-life system over the past 3.5 b.y. were underrepresented. Extended debates that followed generally strong presentations were lively, argumentative, and remarkably civil despite widely held views. The grace with which Jim Lovelock moved between his strongest critics and supporters set high standards for the debates. Everybody acknowledged a high learning curve.

  11. Lichen Planus Pigmentosus: The Controversial Consensus (United States)

    Ghosh, Aparajita; Coondoo, Arijit


    A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches. The disease principally affects the sun-exposed areas of the body such as the face, trunk, and upper extremities. The oral mucosa may rarely be involved. However, the palms, soles, and nails are not affected. Histologically, the epidermis is atrophic along with vacuolar degeneration of basal cell layer. The dermis exhibits incontinence of pigment with scattered melanophages and a sparse follicular or perivascular infiltrate. There is a considerable similarity in histopathological findings between LPP and erythema dyschromicum perstans. However, there are immunologic and clinical differences between the two. These observations have led to a controversy regarding the identity of the two entities. While some dermatologists consider them to be the same, others have opined that the two should be considered as distinctly different diseases. A number of associations such as hepatitis C virus infection, frontal fibrosing alopecia, acrokeratosis of Bazex and nephrotic syndrome have been reported with LPP. A rare variant, LPP inversus, with similar clinical and histopathological findings was reported in 2001. As opposed to LPP, this variant occurs in covered intertriginous locations such as groins and axillae and mostly affects white-skinned persons. PMID:27688435

  12. Addressing the nuclear controversy on university campuses

    International Nuclear Information System (INIS)

    Keyes, G.B.; Poncelet, C.G.


    A strong anti-nuclear sentiment exists on many university campuses. Young minds are eager to adopt causes which purport to reflect new intellectual approaches to social, political, and economic issues. Hence, the opposition to nuclear power can be made to seem to be based on: 1) technical study of nuclear plants; 2) concern for the environment; 3) concern for public health and safety; 4) requirements for an improved economic order; and 5) demand for public decision on technical issues. All of these elements have the potential of attracting student and faculty interest and support. To contend with this problem, our company decided to attempt to achieve a dialogue with the student and faculty audiences. A small group of young nuclear engineers was chosen to undergo comprehensive training on the controversy and contemporary campus issues in the states to be visited. The selection and training emphasized the ability of the engineers to relate to the students as their peers. They were encouraged to speak candidly and for themselves. Thus, they were not burdened with the image of being viewed merely as typical corporate spokesmen. The rapport made possible by this approach is a very important element in the success of such an effort. Invitations to debate before student audiences were issued to leading opposition groups; also, to the news media to report the events. Response by the media has been outstandingly favorable: not only has the coverage been extensive, but it has carried the pro-nuclear arguments to large audiences on a scale and with a credibility not otherwise achievable. The results to date have been extremely encouraging. Other countries are invited to learn more about the ''Campus America'' program in order to evaluate whether or not such an approach, with appropriate modification, could prove effective in their own situations

  13. Structured Academic Controversies in the Professional Physical Education Classroom. (United States)

    Overby, Lynnette Young; And Others


    Structured academic controversy is a cooperative learning strategy that can promote learning in theoretical physical education classes at the college level. This article explains how to conduct structured academic controversy, providing examples of topics (e.g., adapted physical education, biomechanics, motor development, and sport psychology).…

  14. Current controversies and future perspectives in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Agustí, Alvar; Vestbo, Jørgen


    Over the past decade there has been much research and interest in COPD. As a result, the understanding and management of the disease has improved significantly. Yet, there are many uncertainties and controversies that require further work. This review discusses these controversies and anticipates...... some of the changes that may occur in the near future in the field of COPD....

  15. Tennessee to Texas: Tracing the Evolution Controversy in Public Education (United States)

    Armenta, Tony; Lane, Kenneth E.


    Darwin's Theory of Evolution has stirred controversy since its inception. Public schools in the United States, pressed by special interest groups on both sides of the controversy, have struggled with how best to teach the theory, if at all. Court cases have dealt with whether states can ban the teaching of evolutionary theory, whether Creationism…

  16. Blackwater fever: An insight into a controversy | Chiabi | Clinics in ...

    African Journals Online (AJOL)

    The authors present a comprehensive review of the possible pathogenetic mechanisms, pathophysiology and therapeutic options of blackwater fever. The review points out some salient controversies from several studies concerning this disorder. It is concluded that despite these controversies in literature, blackwater fever ...

  17. From Classroom to Controversy: Conflict in the Teaching of Religion (United States)

    Neal, Lynn S.


    What happens when a class assignment becomes a source of controversy? How do we respond? What do we learn? By describing the controversy surrounding an assignment on religion and representation, this article examines conflict's productive role in teaching about New Religious Movements (NRMs) and religion. It suggests that we consider how our…

  18. Current controversies and future perspectives in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Agustí, Alvar; Vestbo, Jørgen


    Over the past decade there has been much research and interest in COPD. As a result, the understanding and management of the disease has improved significantly. Yet, there are many uncertainties and controversies that require further work. This review discusses these controversies and anticipates...

  19. Predicting Public Acceptability in Controversial Technologies

    International Nuclear Information System (INIS)

    Bruce, Donald M.


    Technology and society have a synergic relationship. New technologies are a product of the values and aspirations of the culture in which they emerge. In turn, each new technology shapes and alters these values and aspirations, to a greater or lesser degree. The acceptance by society of any particular technology depends, however, on how far the values embodied in the technology reflect those of the wider society, or only those of some privileged sector - perhaps a ruling elite, a group of academic researchers, a commercial company, or even a special interest group. As public disquiet about controversial technologies has grown, their acceptance can no longer be taken for granted. It is now becoming more important to evaluate in advance the degree of likely mismatch between the aspirations of the technologists and the values of society. This paper explores one approach to making this evaluation, based on the notion of a conditional social contract between technology and society. A given society may be prepared to embrace a new technology to deliver certain benefits, and may accept a certain degree of risk and adaptation of life styles, provided certain basic conditions are fulfilled. These conditions include the upholding of basic values, familiarity, how it compares with similar technologies, the degree of control and choice, trust in those in control, the nature of any risks, the tangible benefits, and the media profile given to the new area. If several of these factors are not fulfilled, the technology is unlikely to be accepted. This was dramatically illustrated in the UK public reaction to food products derived from imported US GM soya and maize. These failed nearly all the conditions, so that public rejection should have been seen as a foregone conclusion. In the light of this, the likely public reaction to a number of future biotechnological innovations is assessed, based on the same conditions. Some examples taken from the energy sector are also compared. The

  20. Why Map Issues? On Controversy Analysis as a Digital Method. (United States)

    Marres, Noortje


    This article takes stock of recent efforts to implement controversy analysis as a digital method in the study of science, technology, and society (STS) and beyond and outlines a distinctive approach to address the problem of digital bias. Digital media technologies exert significant influence on the enactment of controversy in online settings, and this risks undermining the substantive focus of controversy analysis conducted by digital means. To address this problem, I propose a shift in thematic focus from controversy analysis to issue mapping. The article begins by distinguishing between three broad frameworks that currently guide the development of controversy analysis as a digital method, namely, demarcationist, discursive, and empiricist. Each has been adopted in STS, but only the last one offers a digital "move beyond impartiality." I demonstrate this approach by analyzing issues of Internet governance with the aid of the social media platform Twitter.

  1. KNOW NUKES: a model for teaching controversial issues

    International Nuclear Information System (INIS)

    Thomashow, M.S.


    This dissertation articulates elements of an educational strategy derived from the experience of the KNOW NUKES program, a teacher training project designed to introduce the nuclear power controversy in the high school classroom. This strategy can be used as means of furthering the effectiveness of controversial issues education, not only in the area of nuclear power, but in teaching about any environmental issue. This is specifically achieved by (2) placing the KNOW NUKES institute in the broader context of controversial issues education; (2) describing in detail KNOW NUKES project planning; (3) reviewing the structure and content of the various teaching techniques and materials that have been developed for the KNOW NUKES institute; (4) utilizing a particular technique developed by the institute that reveals varying perspectives on controversial issues, in this case, an instrumental for decoding the controversial issues that are explicit and implicit in corporate image advertisements; and (5) qualitatively evaluating the practical implementation of the KNOW NUKES model

  2. [Placental complications after a previous cesarean section]. (United States)

    Milosević, Jelena; Lilić, Vekoslav; Tasić, Marija; Radović-Janosević, Dragana; Stefanović, Milan; Antić, Vladimir


    The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complication development. The research was conducted at the Clinic of Gynecology and Obstetrics in Nis covering 10-year-period (from 1995 to 2005) with 32358 deliveries, 1280 deliveries after a previous cesarean section, 131 cases of placenta previa and 118 cases of placental abruption. The experimental groups was presented by the cases of placenta previa or placental abruption with prior cesarean section in obstetrics history, opposite to the control group having the same conditions but without a cesarean section in medical history. The incidence of placenta previa in the control group was 0.33%, opposite to the 1.86% incidence after one cesarean section (pcesarean sections and as high as 14.28% after three cesarean sections in obstetric history. Placental abruption was recorded as placental complication in 0.33% pregnancies in the control group, while its incidence was 1.02% after one cesarean section (pcesarean sections. The difference in the incidence of intrapartal hysterectomy between the group with prior cesarean section (0.86%) and without it (0.006%) shows a high statistical significance (pcesarean section is an important risk factor for the development of placental complications.

  3. A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy


    Zhang, Ren; Abou-Samra, Abdul B


    Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence ...

  4. Is the N170 face specific? Controversy, context, and theory

    Directory of Open Access Journals (Sweden)

    Brian D. Earp


    Full Text Available In cognitive science, there is an ongoing debate about the architecture of the mind: does it consist of a number of mental “organs” each managing a different function in isolation, or is it more of general processor, adaptable to a wide range of tasks? One corner of this debate has centered on face processing. This is because face-perception is crucial to normal human functioning and some evidence shows that faces may be processed by the brain in a privileged way compared to other types of stimuli. For example, in EEG brain recordings, the N170 is a characteristic signal that occurs after a participant is exposed to an image of a face, but it is much less pronounced when other stimuli are shown. More than 15 years of research on the “N170 face effect” have yielded the standard view that the N170 is at the very least face-sensitive, and possibly even face-specific, that is, indexing modular processes tied exclusively to facial geometries. The specificity claim is clearly stronger, and hence subject to significant controversy; while the more conservative “sensitivity” claim had been regarded (until recently as effectively settled. Nevertheless, Thierry and colleagues, in a contentious 2007 article, sought to undermine even this “conservative” consensus: they argued that the apparent face-responsiveness of the N170 in prior research was due to systematic flaws in experimental design. Fiery debate has followed. In this review, we put the debate in its historical and philosophical context, and try to spell out some of the theoretical and logical assumptions that underlie the claims of the competing camps. We then show that the best available evidence counts, at least partially, against the Thierry et al. construal of the N170. Accordingly, it would be premature to abandon the “conservative” account of the N170, according to which it is – minimally – responsive to faces. We conclude by returning to the more controversial claim

  5. The design of an enzyme: a chronology on the controversy. (United States)

    Buc, Henri


    After the publication of the Monod-Wyman-Changeux model, a controversy arose between Jacques Monod, Francis Crick and Jeffries Wyman about the comparison of the regulatory performances of an oligomer undergoing a concerted transition between two states and a monomer having the same composition and subjected to a similar conformational equilibrium. The controversy took place between September 1965 and March 1966. It gave rise to several unpublished notes. Numerous misunderstandings between the participants were not fully dissipated as the controversy abruptly ended. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Understanding and Developing Controversial Issues in College Courses. (United States)

    Payne, Brian K.; Gainey, Randy R.


    Discusses common controversial issues in different college disciplines, such as the death penalty and drug legalization. Also suggests useful methods for encouraging enlightening discussions, such as verbal and physical cues, student-centered activities, and text selection. (SLD)

  7. Electrical stimulation in dysphagia treatment: a justified controversy?

    NARCIS (Netherlands)

    Bogaardt, H. C. A.


    Electrical stimulation in dysphagia treatment: a justified controversy? Neuromuscular electrostimulation (LAMES) is a method for stimulating muscles with short electrical pulses. Neuromuscular electrostimulation is frequently used in physiotherapy to strengthen healthy muscles (as in sports

  8. Summerhill Dismembered: Using Controversy to Motivate Adult Learners. (United States)

    Murray, Louis; Lawrence, Brenda


    Workshops for teachers engaged in practitioner-based inquiry centered on the controversial issues raised by a television documentary on the Summerhill School. Learners normally engaged in distance education were motivated by the processes of dissent, argument, and disputation. (SK)

  9. The Chilling Effect: How Do Researchers React to Controversy? (United States)

    Kempner, Joanna


    Background Can political controversy have a “chilling effect” on the production of new science? This is a timely concern, given how often American politicians are accused of undermining science for political purposes. Yet little is known about how scientists react to these kinds of controversies. Methods and Findings Drawing on interview (n = 30) and survey data (n = 82), this study examines the reactions of scientists whose National Institutes of Health (NIH)-funded grants were implicated in a highly publicized political controversy. Critics charged that these grants were “a waste of taxpayer money.” The NIH defended each grant and no funding was rescinded. Nevertheless, this study finds that many of the scientists whose grants were criticized now engage in self-censorship. About half of the sample said that they now remove potentially controversial words from their grant and a quarter reported eliminating entire topics from their research agendas. Four researchers reportedly chose to move into more secure positions entirely, either outside academia or in jobs that guaranteed salaries. About 10% of the group reported that this controversy strengthened their commitment to complete their research and disseminate it widely. Conclusions These findings provide evidence that political controversies can shape what scientists choose to study. Debates about the politics of science usually focus on the direct suppression, distortion, and manipulation of scientific results. This study suggests that scholars must also examine how scientists may self-censor in response to political events. PMID:19018657

  10. Mapping Controversies with Social Media: The Case for Symmetry

    Directory of Open Access Journals (Sweden)

    Noortje Marres


    Full Text Available This article assesses the usefulness for social media research of controversy analysis, an approach developed in Science and Technology Studies (STS and related fields. We propose that this approach can help to address an important methodological problem in social media research, namely, the tension between social media as resource for social research and as an empirical object in its own right. Initially developed for analyzing interactions between science, technology, and society, controversy analysis has in recent decades been implemented digitally to study public debates and issues dynamics online. A key feature of controversy analysis as a digital method, we argue, is that it enables a symmetrical approach to the study of media-technological dynamics and issue dynamics. It allows us to pay equal attention to the ways in which a digital platform like Twitter mediates public issues, and to how controversies mediate “social media” as an object of public attention. To sketch the contours of such a symmetrical approach, the article discusses examples from a recent social media research project in which we mapped issues of “privacy” and “surveillance” in the wake of the National Security Agency (NSA data leak by Edward Snowden in June 2013. Through a discussion of social media research practice, we then outline a symmetrical approach to analyzing controversy with social media. We conclude that the digital implementation of such an approach requires further exchanges between social media researchers and controversy analysts.

  11. A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. (United States)

    Zhang, Ren; Abou-Samra, Abdul B


    Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. However, the mechanism of action, the identity of transcription factors mediating its nutritional regulation, circulating levels, and relationship among lipasin, Angptl3 and Angptl4, remain elusive. Betatrophin represents a promising drug target for replenishing β-cell mass, but current results have not been conclusive regarding its potency and specificity. Here, we summarize the consensus and controversy regarding functions of lipasin/betatrophin based on currently available evidence.

  12. Studying a Controversy amongst Pashtuns of Torghar, Balochistan, Pakistan

    Directory of Open Access Journals (Sweden)

    Luc Bellon


    Full Text Available Much has been written about the political structures of tribal groups. The present article looks at political dynamics amongst Pashtuns of Balochistan, through the prism of a controversy. The sociological interest of studying the arguments used during a controversy has been underlined by Boltanski and Thevenot. A controversy finishes by the establishment, through consensus, of a common agreement upon accepted norms, determined limits, redefinition of social values, etc. The advantage of focusing on the argumentation itself is to avoid taking the agreement as a pre-established social truth, a reference that concerned people would reluctantly challenge. To study a controversy is to study the social realities in the making, to study the archaeology of collective consensus, to reinstate history, contingencies and individual plurality within the social dynamics and to take seriously their performative actions alongside other social determinisms. This article shows that to study controversy is a way not only to set light on political dynamics and structures, but also to discuss the impact and definition of concepts such as segmentarity, equality, rights, interests, and their relevance within the Pashtun society which was observed.

  13. Controversy and consensus nuclear beta decay 1911-1934

    CERN Document Server

    Jensen, Carsten


    In 1920s, a long-lasting controversy on the interpretation of nuclear beta spectrum arose between Lise Meitner and Charles Drummond Ellis. This controversy, and the reactions from the contending parties when it was settled, reflect clearly the difference between the scientific communities in Berlin and Cambridge at that time. The Meitner-Ellis controversy ended in 1929, and it left an anomaly that attracted leading theoretical physicists. A new dispute, this time between Niels Bohr and Wolfgang Pauli, broke out. It concerned the explanation of the continuity of the primary beta particles and dominated the discussions for the next five years. Pauli argued for a new particle, and Bohr for a new theory; both suggestions were radical steps, but they reflected two different ways of doing physics.

  14. Empowerment in healthcare policy making: three domains of substantive controversy. (United States)

    Chiapperino, Luca; Tengland, Per-Anders


    This paper distinguishes between the uses of empowerment across different contexts in healthcare policy and health promotion, providing a model for the ethical and political scrutiny of those uses. We argue that the controversies currently engendered by empowerment are better understood by means of a historical distinction between two concepts of empowerment, namely, what we call the radical empowerment approach and the new wave of empowerment. Building on this distinction, we present a research agenda for ethicists and policy makers, highlighting three domains of controversy raised by the new wave of empowerment, namely: (1) the relationship between empowerment and paternalistic interferences on the part of professionals; (2) the evaluative commitment of empowerment strategies to the achievement of health-related goals; and (3) the problems arising from the emphasis on responsibility for health in recent uses of empowerment. Finally, we encourage the explicit theorisation of these moral controversies as a necessary step for the development and implementation of ethically legitimate empowerment processes.

  15. Humanitarian law: the controversial historical construction of a universal moral

    Directory of Open Access Journals (Sweden)

    Soraya Nour Sckell


    Full Text Available Humanitarian law was conceived by legal and moral normativism founded on universal principles. Despite its undeniable universal moral content, its formulations and application methods are however the result of historical conflicts. This article aims to analyze how the universality of humanitarian law is produced by highly controversial conflicts. It is necessary to overcome the antagonism between an analysis that focuses on the moral undeniable value of humanitarian law by ignoring its controversies and an analysis that focuses on social antagonism questioning the achievability of the moral and universal value of humanitarian law. For this, we must consider that humanitarian law is a construction. It appears as autonomous and independent of power relationships, as based on the rationality of morality and thus worthy of universal recognition. Yet its development is only possible when one considers the historical roots of reason. It is only through political struggle that humanitarian law is realized in history. The aim of this paper is to analyze how the universal nature of humanitarian law is produced by highly controversial conflicts. Firstly, an analysis is offered on the universal but at the same controversial character in the codification of humanitarian law, recalling controversies around the creation of the Additional Protocols of 1977 (Section 1. Next, an analysis is given on the conflictual character of organizations supporting humanitarian law, taking in account conflicts between the Red Cross and Doctors Without Borders and controversies around the ambitions to pass from an humanitarian law to a right of humanitarian intervention (Section 2. Finally, a reflection is offered on how the theories of international relations that most appropriately grasp the universal nature of humanitarian law must be complemented by a "historical sociology of the universal" that embraces the conflicting historical dimension in the construction of the

  16. Design Piracy: Student Perceptions of a Constructive Controversy Activity (United States)

    Marcketti, Sara B.


    Optimal learning occurs when students are interested in the subject matter, are motivated with challenging and quality learning opportunities, and when immersed in atmospheres that make learning enjoyable. One technique to promote optimal learning is through the use of constructive controversies. The purpose of this study was to provide an example…

  17. "We Make It Controversial": Elementary Preservice Teachers' Beliefs about Race (United States)

    Buchanan, Lisa Brown


    The impetus for this study began during an elementary teacher education course meeting, where preservice teachers discussed whether or not it was appropriate to discuss controversial topics--including race--with young children. Preservice teachers disclosed their "uncomfortableness" with race at large, and emphasized that discussions…

  18. Is Race Really Controversial in the University Classroom? (United States)

    Philion, Stephen


    Today, even though "social justice" programs exist as a virtual growth industry on US campuses and many universities have incorporated classes on race and racism into their curricula, everyone continues to be faced with the perception that race is a "controversial" topic that has to be broached with care due to its "sensitive nature". This is even…

  19. Disaster, Controversy--Are You Prepared for the Worst? (United States)

    Heller, Robert W.; And Others


    Provides demographic profiles from "Executive Educator's" fourth annual survey of U.S. school executives. Regarding disaster preparedness, only a small percentage of all districts in earthquake-prone areas have earthquake and fire action plans. Concerning controversial issues, teaching about substance abuse, child abuse, and teen suicide meets…

  20. Teaching Controversial Issues in the JLL Classroom for Chinese Students (United States)

    Shimojimai, Yasuko


    This paper discusses how teachers explore teaching controversial issues in the Japanese language classroom to Japanese language learner (JLL) or culturally and linguistically diverse (CLD) students who have different cultural and political backgrounds. Assuring educational opportunities with consideration of JLLs' background is important…

  1. Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences (United States)

    Ossorio, Pilar; Duster, Troy


    Among biomedical scientists, there is a great deal of controversy over the nature of race, the relevance of racial categories for research, and the proper methods of using racial variables. This article argues that researchers and scholars should avoid a binary-type argument, in which the question is whether to use race always or never.…

  2. 37 CFR 351.3 - Controversy and further proceedings. (United States)


    ..., the contested amount of a claim is $10,000 or less, the Copyright Royalty Judges shall decide the... CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.3 Controversy and further... negotiation period, the Copyright Royalty Judges will issue an order declaring that further proceedings are...

  3. Luther and Zwingli's Eucharistic Controversy: A Reflection on ...

    African Journals Online (AJOL)

    Luther and Zwingli's Eucharistic Controversy: A Reflection on Nigerian Christianity. ... To Luther and Zwingli, there are two sacraments (baptism and Eucharist) whereas for the Roman Catholic Church, they are seven (baptism, Eucharist, Penance, Confirmation, Marriage, Ordination, and Extreme Unction). The Catholic ...

  4. IQ Test Controversy: Past, Present, and Future Trends. (United States)

    Alford, David W.

    The controversies surrounding the use of intelligence quotient (IQ) tests with children are summarized. This article discusses what intelligence is and how intelligence is measured. It also examines factors which can affect measurement, including examiner training or bias, examinee age, misinterpretation of test scores, and poor tests. The…

  5. Stem Cell Research-Concept And Controversies | Kalu | Benin ...

    African Journals Online (AJOL)

    Benin Journal of Postgraduate Medicine. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 8, No 1 (2006) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Stem Cell Research-Concept And Controversies.

  6. Allocative inefficiency and the capital-energy controversy

    International Nuclear Information System (INIS)

    Christopoulos, Dimitris K.; Tsionas, Efthymios G.


    The purpose of the paper is to estimate a system of input demands for Greek manufacturing deviating from the standard practice of assuming strict cost minimization. The study allows for the presence of price distortions and allocative inefficiency in the decision process. This assumption affects parameter estimates and estimated elasticities materially, and throws new light on the capital-energy controversy in Greek manufacturing

  7. The Ecology Controversy: Opposing Viewpoints. Critical Issues Series. (United States)

    McCuen, Gary E., Ed.; Bender, David L., Ed.

    Ecological problems are explored in this book of sixteen student readings and exercises aimed at developing and applying critical thinking skills. The readings, mostly extracts from books and periodicals, are introduced by the editor and accompanied by questions. Chapter I, The Population Controversy, includes selections from Paul Ehrlich's The…

  8. Science and controversy a biography of Sir Norman Lockyer

    CERN Document Server

    Meadows, A


    Sir Norman Lockyer left Nature, the world''s leading scientific journal, as his lasting memorial. But his life, and controversial theories, are an important part of science history. His ideas were at the forefront of public debate, and ranged from brilliant to perverse. This entertaining book is a fascinating insight into his eventful life

  9. Adolescent Controversial Status Brokers: A Double-Edged Sword (United States)

    Borowski, Sarah; Zeman, Janice; Carboni, Inga; Gilman, Rich; Thrash, Todd


    Using a 3-wave longitudinal, multidimensional approach, this study investigated the influence of social network position and social status on the psychosocial outcomes of 440 youth (45.1% girls; M[subscript age] = 16.1 years; 90.9% Caucasian) over 26 months, focusing on the controversial status classification (i.e., youth who are highly liked and…

  10. [Organic foods and human health: a study of controversies]. (United States)

    Sousa, Anete Araújo de; Azevedo, Elaine de; Lima, Elinete Eliete de; Silva, Ana Paula Ferreira da


    The study of controversies is a methodological tool that generates knowledge about the social and political dimensions of science. This approach can be used to understand and explore the topic of organic foods. The present study aimed to analyze the controversies regarding the status of organic foods. We carried out a review of studies published since 1990 in three websites: International Foundation for Organic Agriculture, Soil Association, and Food and Agriculture Organization. The following controversies were identified: 1) effects on human health of the presence of chemical contaminants in organic foods; 2) the quality of organic foods as compared to conventionally grown foods; and 3) price of organic foods. Based on this review, it is possible to conclude that, even though organic foods stand out for their low toxicity, higher durability, and nutritional content of some items, more comparative studies are required to confirm the nutritional superiority of organic foods and to solve the controversies. The discussion must be contextualized within a broad spectrum of health promotion, in which organic farming appears associated with the support for small farming, biodiversity, and local sustainable development, so as to increase offer and demand for organic products at fair prices for individual and institutional consumers.

  11. Taking One's Principles Seriously: A Teacher Confronts Controversy (United States)

    Hare, William


    A teacher faces hostility from certain colleagues who view his decision to attend a controversial lecture as tantamount to the repudiation of the principle of inclusive education and the rights of students with disabilities. The teacher sees the proposed boycott of the lecture as a form of censorship threatening freedom of inquiry and critical…

  12. Hate Speech: The History of an American Controversy. (United States)

    Walker, Samuel

    Noting that no other country in the world offers protection to offensive speech, this book provides a comprehensive account of the history of the hate speech controversy in the United States. The book examines the issue, from the conflicts over the Ku Klux Klan in the 1920s and American Nazi groups in the 1930s, to the famous Skokie, Illinois…

  13. Financing the UNCED Agenda: The Controversy over Additionality. (United States)

    Jordan, Andrew


    Additionality is the concept that developed countries should finance the costs of developing countries to address global environmental problems and make the transition to sustainable development on top of all other financial aid. Discusses the controversy regarding this concept as discussed at the June 1992 United Nations Conference on Environment…

  14. Should We Teach Homosexuality as a Controversial Issue? (United States)

    Hand, Michael


    Philosophers of education disagree on how the question of the moral status of homosexual acts should be tackled in the classroom. Some argue that the question should be taught as a controversial issue, that we should present rival moral positions as even-handedly as possible; others maintain that we should actively promote the view that homosexual…

  15. Integration of basic controversies in cross-cultural psychology

    NARCIS (Netherlands)

    Poortinga, Y.H.


    This article discusses controversies in the field of cross-cultural psychology, including cultural psychology, with a view to possible integration.1 It briefly describes the indigenisation movement as a reaction against Western scientific ethnocentrism and mentions two methodological topics, that

  16. Some diagnostic and therapeutic controversies in glaucoma addressed

    NARCIS (Netherlands)

    Müskens, Rogier Peter Hendrik Maria


    In the five studies contained in this thesis, several controversies on the diagnosis of and therapy for glaucoma have been addressed. The first part of this thesis consisted of three studies that aimed tot improve existing technologies for diagnosing glaucoma. The latter part consisted of two

  17. ORIGINAL ARTICLES Ethical and legal controversies in cloning for ...

    African Journals Online (AJOL)

    Ethical and legal controversies in cloning for biomedical research - a South African perspective. A Dhai, J Moodley, D J McQuoid-Mason, C Rodeck. Therapeutic embryonic stem cell research raises a number of ethical and legal issues. The promised benefits are new and important knowledge of human embryological ...

  18. Ethical Perspectives on the Current Controversy Regarding Openness in Adoption. (United States)

    Tavis, Timothy M.

    This paper outlines current changes in American adoption practice and the controversies surrounding these changes. It includes a discussion of the role that neo-Kantian and utilitarian perspectives have played in American adoption policy and practice, and offers an alternative, the communitarian perspective, described by Sandel (1984). Adoption…

  19. Maintaining Legitimacy: Controversies, Orders of Worth and Public Justifications

    NARCIS (Netherlands)

    Patriotta, G.; Gond, J.-P.; Schultz, F.


    We build on Boltanski and Thévenot's theory of justification to account for the ways in which different stakeholder groups actively engage with discourses and objects to maintain the legitimacy of institutions that are relevant to their activity. We use this framework to analyse a controversy

  20. Controversial Therapies for Young Children with Developmental Disabilities. (United States)

    Nickel, Robert E.


    This article examines reasons parents may choose a controversial alternative treatment for a child with developmental disabilities and reviews a few specific treatments--vitamin B-6 and magnesium, auditory integration training, megavitamins and minerals, Piracetam, intravenous immunoglobulin, and melatonin. Recommendations on talking with families…

  1. The cartoon controversy as a case of multiculturalrecognition

    DEFF Research Database (Denmark)

    Lægaard, Sune


    The paper considers what ‘recognition' might mean in theory and which policies would in practice qualify as policies of recognition in relation to multicultural conflicts such as the ‘cartoon controversy' sparked by the publication of drawings of the Prophet Mohammad in the Danish Newspaper...

  2. Placental complications after a previous cesarean section


    Milošević Jelena; Lilić Vekoslav; Tasić Marija; Radović-Janošević Dragana; Stefanović Milan; Antić Vladimir


    Introduction The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complic...

  3. It's the Physics: Organized Complexity in the Arctic/Midlatitude Weather Controversy (United States)

    Overland, J. E.; Francis, J. A.; Wang, M.


    There is intense scientific and public interest in whether major Arctic changes can and will impact mid-latitude weather. Despite numerous workshops and a growing literature, convergence of understanding is lacking, with major objections about possible large impacts within the scientific community. Yet research on the Arctic as a new potential driver in improving subseasonal forecasting at midlatitudes remains a priority. A recent review laid part of the controversy on shortcomings in experimental design and ill-suited metrics, such as examining the influence of only sea-ice loss rather than overall Arctic temperature amplification, and/or calculating averages over large regions, long time periods, or many ensemble members that would tend to obscure event-like Arctic connections. The present analysis lays the difficulty at a deeper level owing to the inherently complex physics. Jet-stream dynamics and weather linkages on the scale of a week to months has characteristics of an organized complex system, with large-scale processes that operate in patterned, quasi-geostrophic ways but whose component feedbacks are continually changing. Arctic linkages may be state dependent, i.e., relationships may be more robust in one atmospheric wave pattern than another, generating intermittency. The observational network is insufficient to fully initialize such a system and the inherent noise obscures linkage signals, leading to an underdetermined problem; often more than one explanation can fit the data. Further, the problem may be computationally irreducible; the only way to know the result of these interactions is to trace out their path over time. Modeling is a suggested approach, but at present it is unclear whether previous model studies fully resolve anticipated complexity. The jet stream from autumn to early winter is characterized by non-linear interactions among enhanced atmospheric planetary waves, irregular transitions between the zonal and meridional flows, and the

  4. Understanding the agreements and controversies surrounding childhood psychopharmacology

    Directory of Open Access Journals (Sweden)

    Johnston Josephine


    Full Text Available Abstract The number of children in the US taking prescription drugs for emotional and behavioral disturbances is growing dramatically. This growth in the use of psychotropic drugs in pediatric populations has given rise to multiple controversies, ranging from concerns over off-label use and long-term safety to debates about the societal value and cultural meaning of pharmacological treatment of childhood behavioral and emotional disorders. This commentary summarizes the authors' eight main findings from the first of five workshops that seek to understand and produce descriptions of these controversies. The workshop series is convened by The Hastings Center, a bioethics research institute located in Garrison, New York, U.S.A.

  5. Using deliberation to address controversial issues: Developing Holocaust education curriculum.

    Directory of Open Access Journals (Sweden)



    Full Text Available This paper explores how a cross-cultural project responded to the need for new Holocaust educational materials for the Republic of Latvia through the method of curriculum deliberation. Analysis of interview, observational, and document data drawn from seven curriculum writers and numerous project members suggest that curriculum deliberation helped awaken a controversial and silenced history while attending to a wide range of needs and concerns for a variety of stakeholders. The findings highlight structural features that empowered the curriculum writers as they engaged in protracted rumination, reflected upon competing norms, and considered the nuances of the curriculum problem in relation to implementation. Understanding the process, challenges, and promises of cross-cultural curriculum deliberation holds significance for educators, curricularists, and educational researchers wishing to advance teaching and learning within silenced histories and controversial issues.

  6. Behavioural controversy concerning homo economicus: a Humean perspective

    Directory of Open Access Journals (Sweden)

    Khandakar Elahi


    Full Text Available In his monumental masterpiece, A Treatise on Human Nature, which explains the methodology of human reasoning concerning matters of fact and describes the roles that passions and morals play in it, Hume arrives at an enormously interesting maxim: An academic controversy cannot continue for long unless the disputants assign different meanings to the major terms employed in the debate. This theory has been applied in this paper to examine the behavioural criticisms about Homo Economicus (HE, the pivotal perception in the neoclassical microeconomic model.To achieve this objective, the paper discusses the origin and evolution of the concept, reviews behavioural criticisms, summarises the main tenets of Hume’s philosophy of human knowledge and finally examines the behavioural opinions from Hume’s perspective. The paper concludes that Hume’s theory convincingly explains the reason why the HE controversy is continuing for over half century- a fact that both the mainstream and behavioural economists are ignoring.

  7. Nuclear energy: public controversies and the analysis of risks

    International Nuclear Information System (INIS)

    Sills, D.L.


    Energy is a social concept, the product of social, economic, and political processes that define certain raw materials as resources and thus convert them into usable energy. Like all social concepts, energy is controversial. Out of a wide range of controversies, three are selected for analysis here: (1) the relationship of nuclear power systems to nuclear weapons proliferation; (2) the risks of terrorism and sabotage associated with the operation of nuclear power facilities, including threats to civil liberties; and (3) the problems associated with the long-term management of radioactive wastes. The final section of the paper describes various modes of analyzing risks and the perception of risks. It is concluded that it may take many decades to learn whether nuclear energy is as natural a source of electrical power as wells are of drinking water, or whether nuclear energy is a horror that mankind in the 1980s or 1990s took a hard look at and then backed away. (author)

  8. Results of a European survey on current controversies in otology. (United States)

    Preuss, Simon Florian; Luers, Jan-Christoffer; Beutner, Dirk; Klussmann, Jens Peter; Huttenbrink, Karl Bernd


    Various topics in otology cause controversy among otologists internationally. The resulting variety of diagnostic and surgical concepts reflects differences between surgical schools and the lack of structured studies in the field. During the "Third Instructional Workshop of the European Academy of Otology and Neuro-Otology," we interviewed 100 invited instructors using a written questionnaire on 13 controversial topics in otology. The analyses of the survey showed a variety of different approaches in most otologic topics. A further exchange of experiences and discussions in expert panels such as the Instructional Workshop of the European Academy of Otology and Neuro-Otology may help standardize concepts in otology for a safe, efficient, and cost-effective standard of care in otology.

  9. Distinguishing heat from light in debate over controversial fossils. (United States)

    Donoghue, Philip C J; Purnell, Mark A


    Fossil organisms offer our only direct insight into how the distinctive body plans of extant organisms were assembled. However, realizing the potential evolutionary significance of fossils can be hampered by controversy over their interpretation. Here, as a guide to evaluating palaeontological debates, we outline the process and pitfalls of fossil interpretation. The physical remains of controversial fossils should be reconstructed before interpreting homologies, and choice of interpretative model should be explicit and justified. Extinct taxa lack characters diagnostic of extant clades because the characters had not yet evolved, because of secondary loss, or because they have rotted away. The latter, if not taken into account, will lead to the spurious assignment of fossils to basally branching clades. Conflicting interpretations of fossils can often be resolved by considering all the steps in the process of anatomical analysis and phylogenetic placement, although we must accept that some fossil organisms are simply too incompletely preserved for their evolutionary significance to be realized.

  10. The pertussis vaccine controversy in Great Britain, 1974-1986. (United States)

    Baker, Jeffrey P


    This historical essay analyzes the role played by Great Britain in the pertussis vaccine controversy of the 1970s and 1980s. Public backlash against this vaccine not only took place earlier in Britain than the United States, but also was so widespread that a series of whooping cough epidemics soon followed. As with the more recent dispute involving measles-mumps-rubella (MMR) vaccine and autism, the United Kingdom played a primary role in defining, promoting, and ultimately exporting this controversy. This essay seeks to explain this phenomenon by situating it in Britain's long history of suspicion regarding vaccines evident among both the public and the medical profession, a theme dating back to the compulsory vaccination laws of the 19th century. It argues that anti-vaccinationism, far from being simply a new development related to the public's lack of awareness of childhood vaccine-preventable illness, actually represents a revival of a much older movement.

  11. Mercury, vaccines, and autism: one controversy, three histories. (United States)

    Baker, Jeffrey P


    The controversy regarding the once widely used mercury-containing preservative thimerosal in childhood vaccines has raised many historical questions that have not been adequately explored. Why was this preservative incorporated in the first place? Was there any real evidence that it caused harm? And how did thimerosal become linked in the public mind to the "autism epidemic"? I examine the origins of the thimerosal controversy and their legacy for the debate that has followed. More specifically, I explore the parallel histories of three factors that converged to create the crisis: vaccine preservatives, mercury poisoning, and autism. An understanding of this history provides important lessons for physicians and policymakers seeking to preserve the public's trust in the nation's vaccine system.

  12. Unconsciously against it. Psychological aspects of the nuclear controversy

    International Nuclear Information System (INIS)

    Wuenschmann, A.


    The book deals with the psychological aspects of the nuclear controversy. An attempt is made to describe, in psychological terms, arrange, explain and, in this sense, 'comprehend' the phenomenon of the nuclear controversy in the light of the following facts: - individual and archetypal spectra of associations arising in the minds of many people in combination with the term 'nuclear power plant', the existence of different psychological types; the suggestion and psychological regression in the group. Especially the nuclear opponents, more or less successfully, have used the individual and archetypal association spectrum as an instrument to further their own ends and have thus contributed to the erection of psychological barriers against nuclear power in the minds of many people. (orig./RW) [de

  13. The nuclear controversy as reflected in the daily newspapers

    International Nuclear Information System (INIS)

    Buire, S. van.


    The development and utilization of nuclear energy has led to conflicts of larger dimensions in our society. What has been the role of the mass communication media in this discussion. Did they fulfill their duty to inform the public, did they actively foster discussions about the facts to be considered, and did they play their part in public opinion making by publishing critical analyses. These are questions answered by this book by presenting analyses of newspaper articles on the nuclear controversy, facts and figures on the opinions and information published in the daily newspapers on the subject of nuclear energy utilization, and analyses of tendencies pro or contra nuclear energy as expressed by the various articles. By an evaluation of the history of discussions, the development and modifications of the arguments put forward and the reactions shown by the various social groups involved in the process are illustrated and commented in the light of the controversy becoming more acute. (orig./HP) [de

  14. Preoperative screening: value of previous tests. (United States)

    Macpherson, D S; Snow, R; Lofgren, R P


    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  15. Controversies in the Management of Endometrial Carcinoma: An Update

    Directory of Open Access Journals (Sweden)

    Mohamed K. Mehasseb


    Full Text Available Endometrial carcinoma is the commonest type of female genital tract malignancy in the developed countries. Endometrial carcinoma is usually confined to the uterus at the time of diagnosis and as such usually carries an excellent prognosis with high curability. Our understanding and management of endometrial cancer have continuously developed. Current controversies focus on screening and early detection, the extent of nodal surgery, and the changing roles of radiation therapy and chemotherapy and will be discussed in this paper.

  16. The tidelands oil controversy: The prize and the responsibility

    Energy Technology Data Exchange (ETDEWEB)

    Hagar, A.V.


    This article reviews the legal history of the Tidelands oil controversy in the Santa Barbara Channel of Southern California. A blowout of a well in an offshore platform in 1969 marked the beginning of California`s anti-oil movement. Santa Barbara today is a combination of industrialization and recreation, and like the oil and water that are the lifeblood of these two pursuits, they do not mix.

  17. Controversies and challenges of vaccination: an interview with Elizabeth Miller


    Miller, Elizabeth


    Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine refusers and hesitators, the resulting health consequences, and ways in which health professionals and industry regulators can help promote transparency to better convey the sub...

  18. Controversies and challenges of vaccination: an interview with Elizabeth Miller. (United States)

    Miller, Elizabeth


    Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine refusers and hesitators, the resulting health consequences, and ways in which health professionals and industry regulators can help promote transparency to better convey the substantial health benefits of vaccination.

  19. Controversies in knee rehabilitation: anterior cruciate ligament injury. (United States)

    Failla, Mathew J; Arundale, Amelia J H; Logerstedt, David S; Snyder-Mackler, Lynn


    Controversy in management of athletes exists after anterior cruciate ligament (ACL) injury and reconstruction. Consensus criteria for evaluating successful outcomes following ACL injury include no reinjury or recurrent giving way, no joint effusion, quadriceps strength symmetry, restored activity level and function, and returning to preinjury sports. Using these criteria, the success rates of current management strategies after ACL injury are reviewed and recommendations are provided for the counseling of athletes after ACL injury. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues


    Russo, Ethan B.


    This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements for production of cannabis-based medicines, particularly the Food and Drug Administration “Botanical Guidance.” The remainder pertains to various cannabis controversies that certainly require closer examination if the scientific, consumer, and governmental stakeholders are ever to reach consensus on safety issues, specifically: whether botanica...

  1. Controversies in the Surgical Management of Spinal Cord Injuries

    Directory of Open Access Journals (Sweden)

    Ahmed M. Raslan


    Full Text Available Traumatic spinal cord injury (SCI affects over 200,000 people in the USA and is a major source of morbidity, mortality, and societal cost. Management of SCI includes several components. Acute management includes medical agents and surgical treatment that usually includes either all or a combination of reduction, decompression, and stabilization. Physical therapy and rehabilitation and late onset SCI problems also play a role. A review of the literature in regard to surgical management of SCI patients in the acute setting was undertaken. The controversy surrounding whether reduction is safe, or not, and whether prereduction magnetic resonance (MR imaging to rule out traumatic disc herniation is essential is discussed. The controversial role of timing of surgical intervention and the choice of surgical approach in acute, incomplete, and acute traumatic SCI patients are reviewed. Surgical treatment is an essential tool in management of SCI patients and the controversy surrounding the timing of surgery remains unresolved. Presurgical reduction is considered safe and essential in the management of SCI with loss of alignment, at least as an initial step in the overall care of a SCI patient. Future prospective collection of outcome data that would suffice as evidence-based is recommended and necessary.

  2. The controversy over the minimum quantum requirement for oxygen evolution. (United States)

    Hill, Jane F; Govindjee


    During the early- to mid-twentieth century, a bitter controversy raged among researchers on photosynthesis regarding the minimum number of light quanta required for the evolution of one molecule of oxygen. From 1923 until his death in 1970, Otto Warburg insisted that this value was about three or four quanta. Beginning in the late 1930s, Robert Emerson and others on the opposing side consistently obtained a value of 8-12 quanta. Warburg changed the protocols of his experiments, sometimes in unexplained ways, yet he almost always arrived at a value of four or less, except eight in carbonate/bicarbonate buffer, which he dismissed as "unphysiological". This paper is largely an abbreviated form of the detailed story on the minimum quantum requirement of photosynthesis, as told by Nickelsen and Govindjee (The maximum quantum yield controversy: Otto Warburg and the "Midwest-Gang", 2011); we provide here a scientific thread, leaving out the voluminous private correspondence among the principal players that Nickelsen and Govindjee (2011) examined in conjunction with their analysis of the principals' published papers. We explore the development and course of the controversy and the ultimate resolution in favor of Emerson's result as the phenomenon of the two-light-reaction, two-pigment-system scheme of photosynthesis came to be understood. In addition, we include a brief discussion of the discovery by Otto Warburg of the requirement for bicarbonate in the Hill reaction.

  3. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.


    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  4. Concomitant and previous osteoporotic vertebral fractures. (United States)

    Lenski, Markus; Büser, Natalie; Scherer, Michael


    Background and purpose - Patients with osteoporosis who present with an acute onset of back pain often have multiple fractures on plain radiographs. Differentiation of an acute osteoporotic vertebral fracture (AOVF) from previous fractures is difficult. The aim of this study was to investigate the incidence of concomitant AOVFs and previous OVFs in patients with symptomatic AOVFs, and to identify risk factors for concomitant AOVFs. Patients and methods - This was a prospective epidemiological study based on the Registry of Pathological Osteoporotic Vertebral Fractures (REPAPORA) with 1,005 patients and 2,874 osteoporotic vertebral fractures, which has been running since February 1, 2006. Concomitant fractures are defined as at least 2 acute short-tau inversion recovery (STIR-) positive vertebral fractures that happen concomitantly. A previous fracture is a STIR-negative fracture at the time of initial diagnostics. Logistic regression was used to examine the influence of various variables on the incidence of concomitant fractures. Results - More than 99% of osteoporotic vertebral fractures occurred in the thoracic and lumbar spine. The incidence of concomitant fractures at the time of first patient contact was 26% and that of previous fractures was 60%. The odds ratio (OR) for concomitant fractures decreased with a higher number of previous fractures (OR =0.86; p = 0.03) and higher dual-energy X-ray absorptiometry T-score (OR =0.72; p = 0.003). Interpretation - Concomitant and previous osteoporotic vertebral fractures are common. Risk factors for concomitant fractures are a low T-score and a low number of previous vertebral fractures in cases of osteoporotic vertebral fracture. An MRI scan of the the complete thoracic and lumbar spine with STIR sequence reduces the risk of under-diagnosis and under-treatment.

  5. Surgical treatment of breast cancer in previously augmented patients. (United States)

    Karanas, Yvonne L; Leong, Darren S; Da Lio, Andrew; Waldron, Kathleen; Watson, James P; Chang, Helena; Shaw, William W


    The incidence of breast cancer is increasing each year. Concomitantly, cosmetic breast augmentation has become the second most often performed cosmetic surgical procedure. As the augmented patient population ages, an increasing number of breast cancer cases among previously augmented women can be anticipated. The surgical treatment of these patients is controversial, with several questions remaining unanswered. Is breast conservation therapy feasible in this patient population and can these patients retain their implants? A retrospective review of all breast cancer patients with a history of previous augmentation mammaplasty who were treated at the Revlon/UCLA Breast Center between 1991 and 2001 was performed. During the study period, 58 patients were treated. Thirty patients (52 percent) were treated with a modified radical mastectomy with implant removal. Twenty-eight patients (48 percent) underwent breast conservation therapy, which consisted of lumpectomy, axillary lymph node dissection, and radiotherapy. Twenty-two of the patients who underwent breast conservation therapy initially retained their implants. Eleven of those 22 patients (50 percent) ultimately required completion mastectomies with implant removal because of implant complications (two patients), local recurrences (five patients), or the inability to obtain negative margins (four patients). Nine additional patients experienced complications resulting from their implants, including contracture, erosion, pain, and rupture. The data illustrate that breast conservation therapy with maintenance of the implant is not ideal for the majority of augmented patients. Breast conservation therapy with explantation and mastopexy might be appropriate for rare patients with large volumes of native breast tissue. Mastectomy with immediate reconstruction might be a more suitable choice for these patients.

  6. Uterine rupture without previous caesarean delivery

    DEFF Research Database (Denmark)

    Thisted, Dorthe L. A.; H. Mortensen, Laust; Krebs, Lone


    OBJECTIVE: To determine incidence and patient characteristics of women with uterine rupture during singleton births at term without a previous caesarean delivery. STUDY DESIGN: Population based cohort study. Women with term singleton birth, no record of previous caesarean delivery and planned...... vaginal delivery (n=611,803) were identified in the Danish Medical Birth Registry (1997-2008). Medical records from women recorded with uterine rupture during labour were reviewed to ascertain events of complete uterine rupture. Relative Risk (RR) and adjusted Relative Risk Ratio (aRR) of complete uterine...... rupture with 95% confidence intervals (95% CI) were ascertained according to characteristics of the women and of the delivery. RESULTS: We identified 20 cases with complete uterine rupture. The incidence of complete uterine rupture among women without previous caesarean delivery was about 3...

  7. Resolving an 80-yr-old controversy: the beginning of the modern era of renal physiology. (United States)

    Jamison, Rex L


    Marcello Malpighi discovered the glomerulus that bears his name in the 17th century, but it was not until the middle of the 19th century, in 1842, that William Bowman in London published his studies of the histological structure of the glomerulus and proposed that urine formation begins with glomerular secretion. At nearly the same time in Marburg, Carl Ludwig, unaware of Bowman's findings, proposed that urine formation begins with glomerular filtration followed by tubule reabsorption. The controversy lasted 80 yr. Prominent investigators weighed in on both sides. Rudolph Heidenhain's findings in 1874 swung the pendulum toward Bowman's theory until Arthur Cushny published his book, The Secretion of Urine, in 1917, in which he found the evidence insufficient to prove either theory. In 1921, a young physician, Joseph Wearn, began his postresidency training in the laboratory of Alfred N. Richards. He read Cushny's book and learned how to expose the glomerulus of a living frog. Richards proposed that Wearn use that experimental preparation to inject epinephrine into the glomerulus. Wearn proposed a different experiment: instead of using injection, collect fluid from the glomerulus and analyze it. Richards agreed, and the landmark results of that experiment, published in 1924, settled the controversy. The modern era of renal physiology was born. Copyright © 2014 The American Physiological Society.

  8. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    pregnancy if they were married, educated, had dental insurance, previously used dental services when not pregnant, or had knowledge about the possible connection between oral health and pregnancy outcome8. The purpose of this study was to explore the factors determining good oral hygiene among pregnant women ...

  9. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    The perceptions of educational manag ers from previously disadvantaged primary and high schools in the Nelson Mandela Metropole regarding the issue of empowerment are outlined and the perceptions of educational managers in terms of various aspects of empowerment at different levels reflected. A literature study ...

  10. Management of choledocholithiasis after previous gastrectomy. (United States)

    Anwer, S; Egan, R; Cross, N; Guru Naidu, S; Somasekar, K


    Common bile duct stones in patients with a previous gastrectomy can be a technical challenge because of the altered anatomy. This paper presents the successful management of two such patients using non-traditional techniques as conventional endoscopic retrograde cholangiopancreatography was not possible.

  11. Laboratory Grouping Based on Previous Courses. (United States)

    Doemling, Donald B.; Bowman, Douglas C.


    In a five-year study, second-year human physiology students were grouped for laboratory according to previous physiology and laboratory experience. No significant differences in course or board examination performance were found, though correlations were found between predental grade-point averages and grouping. (MSE)

  12. Radiotherapy in prostate cancer. Innovative techniques and current controversies

    Energy Technology Data Exchange (ETDEWEB)

    Geinitz, Hans [Krankenhaus der Barmherzigen Schwestern, Linz (Austria). Dept. of Radiation Oncology; Linz Univ. (Austria). Medical Faculty; Roach, Mack III [California Univ., San Francisco, CA (United States). Dept. of Radiation Oncology; Van As, Nicholas (ed.) [The Institute of Cancer Research, Sutton Surrey (United Kingdom)


    Examines in detail the role of innovative radiation techniques in the management of prostate cancer, including IMRT, IGRT, BART, and modern brachytherapy. Explores a range of current controversies in patient treatment. Intended for both radiation oncologists and urologists. Radiation treatment is rapidly evolving owing to the coordinated research of physicists, engineers, computer and imaging specialists, and physicians. Today, the arsenal of ''high-precision'' or ''targeted'' radiotherapy includes multimodal imaging, in vivo dosimetry, Monte Carlo techniques for dose planning, patient immobilization techniques, intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), biologically adapted radiotherapy (BART), quality assurance methods, novel methods of brachytherapy, and, at the far end of the scale, particle beam radiotherapy using protons and carbon ions. These approaches are like pieces of a puzzle that need to be put together to provide the prostate cancer patient with high-level optimized radiation treatment. This book examines in detail the role of the above-mentioned innovative radiation techniques in the management of prostate cancer. In addition, a variety of current controversies regarding treatment are carefully explored, including whether prophylactic treatment of the pelvic lymphatics is essential, the magnitude of the effect of dose escalation, whether a benefit accrues from hypofractionation, and what evidence exists for the superiority of protons or heavy ions. Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies is intended for both radiation oncologists and urologists with an interest in the up-to-date capabilities of modern radiation oncology for the treatment of prostate cancer.

  13. Controversies in the management of tongue base cancer.

    LENUS (Irish Health Repository)

    O'Neill, J P


    BACKGROUND: Tongue base cancer is one of the most lethal head and neck cancers. There is considerable controversy in the management of this disease with wide variation of opinion within the literature. METHODS: We discuss the presentation, diagnostic and therapeutic strategies which exist in the literature. Articles were reviewed from 1970 to 2007 within the Medline, Pubmed and Cochrane libraries. CONCLUSIONS: Smokers with a history of persistent unilateral neck pain, even in the absence of clinical signs warrant MRI neck imaging. Tongue base cancer organ preservation therapeutic strategies, radiation and concomitant platinum based chemotherapy, currently optimise oncologic and quality of life outcomes.

  14. Current controversies in infective endocarditis [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Thomas J. Cahill


    Full Text Available Infective endocarditis is a life-threatening disease caused by a focus of infection within the heart. For clinicians and scientists, it has been a moving target that has an evolving microbiology and a changing patient demographic. In the absence of an extensive evidence base to guide clinical practice, controversies abound. Here, we review three main areas of uncertainty: first, in prevention of infective endocarditis, including the role of antibiotic prophylaxis and strategies to reduce health care-associated bacteraemia; second, in diagnosis, specifically the use of multimodality imaging; third, we discuss the optimal timing of surgical intervention and the challenges posed by increasing rates of cardiac device infection.

  15. Journalism, controversy and convincing practices: the words and the training

    Directory of Open Access Journals (Sweden)

    Francisco José Castilhos Karam


    Full Text Available Journalism is raised by Greco-RomanRhetoric and Dialectics and comes through thepresent days without ever giving up on its centralpillar: words. Words are to be found everywhere:in writt en texts, static or dynamic images; in infographicsand great, typical journalistic tales. Theyare to be found in chronics, comics, informal talkand social networks. To become a journalist meansto not give up on words that are central when oneacknowledges the importance of the surroundings,of detection methods and narrative models. Wordsare at the core of controversy and convincing practices.They are at the core of becoming a journalist.

  16. Laparoscopic surgery for inguinal hernia: Current status and controversies

    Directory of Open Access Journals (Sweden)

    Bhandarkar Deepraj


    Full Text Available Repair of inguinal hernia is one of the commonest operations performed by surgeons around the world. The treatment of this common problem has seen an evolution from the pure tissue repairs to the prosthetic repairs and in the recent past to laparoscopic repair. The fact that so many hernia repairs are practiced is a testimony to the fact that probably none is distinctly superior to the other. This review assesses the current status of surgery for repair of inguinal hernia and examines the various controversial issues surrounding the subject.

  17. The nuclear controversy: unequal competition in public policy-making

    International Nuclear Information System (INIS)

    Sanderson, I.


    The subject is discussed under the headings: introduction; some epistemological problems; energy policy-making and the energy crisis; the nuclear controversy - substantive issues (the need for nuclear power; the desirability of nuclear power (safety of nuclear power; cost of nuclear power; nuclear power and weapons proliferation; nuclear power and civil liberties; some other aspects of nuclear power development); conclusion); the dominance of pro-nuclear thinking; conclusion and prospects. Appendix A describes the structure of the UK nuclear industry and its European connections. (U.K.)

  18. Controversies on the Publishing of the Newspaper “Curentul”

    Directory of Open Access Journals (Sweden)

    Fănel Teodoraşcu


    Full Text Available The emergence of “Curentul” Journal has been enthusiastically welcomed by the readers, this publication bringing a fresh vim to the Romanian inter-war press. Many contemporary journalists have distrustfully considered Pamfil Șeicaru‟s Journal. This “horrendous” journalist was charged by his peers of having sustained this publication with funding provided by the Government. The controversies derived from this subject can be found in the articles and memories of those who knew the director of “Curentul”, but also in the novels which had him as a source of inspiration.

  19. When ideology and controversy collide: the case of Soviet science. (United States)

    Graham, L R


    Using specific examples such as the recombinant DNA debate, the author compares Soviet and American decision-making procedures in resolving bioethical controversies. In the Soviet Union, the dominant approach is for specialists to arrive at the "correct" position inherent in the world view of Marxism-Leninism. In the United States, it is common to negotiate a compromise between what science can achieve and what defenders of old values are willing to accept. The author concludes that, in both countries, resolution of biomedical issues is influenced more by culture and tradition than by logic and reason.

  20. Breast cancer screening controversies: who, when, why, and how? (United States)

    Chetlen, Alison; Mack, Julie; Chan, Tiffany


    Mammographic screening is effective in reducing mortality from breast cancer. The issue is not whether mammography is effective, but whether the false positive rate and false negative rates can be reduced. This review will discuss controversies including the reduction in breast cancer mortality, overdiagnosis, the ideal screening candidate, and the optimal imaging modality for breast cancer screening. The article will compare and contrast screening mammography, tomosynthesis, whole-breast screening ultrasound, magnetic resonance imaging, and molecular breast imaging. Though supplemental imaging modalities are being utilized to improve breast cancer diagnosis, mammography still remains the gold standard for breast cancer screening. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. The Effect of Academic Controversy Technique on Turkish Teachers Candidates' Success to Effective Speaking Skills and Its Relation with Some Variables (Gender, Multilingualism) (United States)

    Karda, Mehmet Nuri


    The aim of this study is to determine the effect of Academic controversy as a technique of collaborative learning on Turkish Teachers candidates' success to effective speaking skills and its relationship with variables like gender and multilingualism. Therefore the experimental design based on the pre-test and post-test measurement with control…

  2. Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions. (United States)

    Chinn, Steven B; Myers, Jeffrey N


    Oral cavity carcinoma (OCC) remains a major cause of morbidity and mortality in patients with head and neck cancer. Although the incidence has decreased over the last decade, outcomes remain stagnant with only a 5% improvement in overall survival in the last 20 years. Although surgical resection remains the primary treatment modality, several areas of controversy exist with regard to work-up, management of the primary and neck tumors, and adjuvant therapy. As surgical techniques evolve, so has the delivery of radiotherapy and systemic treatment, which have helped to improve the outcomes for patients with advanced disease. Recently, the addition of cetuximab has shown promise as a way to improve outcomes while minimizing toxicity, and this remains an active area of study in the adjuvant setting. Advances in microvascular free-flap reconstruction have extended the limits of resection and enabled enhanced restoration of function and cosmesis. While these advances have led to limited survival benefit, evaluation of alternative modalities has gained interest on the basis of success in other head and neck subsites. Organ preservation with definitive chemoradiotherapy, though proven in the larynx and pharynx, remains controversial in OCC. Likewise, although the association of human papillomavirus is well established in oropharyngeal carcinoma, it has not been proven in the pathogenesis or survival of OCC. Future study of the molecular biology and pathogenesis of OCC should offer additional insight into screening, treatment selection, and novel therapeutic approaches. © 2015 by American Society of Clinical Oncology.

  3. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. (United States)

    Dessinioti, Clio; Katsambas, Andreas


    Seborrheic dermatitis (SD) is a common skin condition seen frequently in clinical practice. The use of varying terms such as sebopsoriasis, seborrheic dermatitis, seborrheic eczema, dandruff, and pityriasis capitis reflects the complex nature of this condition. Despite its frequency, much controversy remains regarding the pathogenesis of SD. This controversy extends to its classification in the spectrum of cutaneous diseases, having being classified as a form of dermatitis, a fungal disease, or an inflammatory disease, closely related with psoriasis. Some have postulated that SD is caused by Malassezia yeasts, based on the observation of their presence in affected skin and the therapeutic response to antifungal agents. Others have proposed that Malassezia is incidental to a primary inflammatory dermatosis that resulted in increased cell turnover, scaling, and inflammation in the epidermis, similar to psoriasis. The presence of host susceptibility factors, permitting the transition of M furfur to its pathogenic form, may be associated with immune response and inflammation. Metabolites produced by Malassezia species, including oleic acid, malssezin, and indole-3-carbaldehyde, have been implicated. SD also has been traditionally considered to be a form of dermatitis based on the presence of Malassezia in healthy skin, the absence the pathogenic mycelial form of Malassezia yeasts in SD, and its chronic course. As a result, proposed treatments vary, ranging from topical corticosteroids to topical antifungals and antimicrobial peptides. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Skin diseases associated with Malassezia yeasts: facts and controversies. (United States)

    Gaitanis, Georgios; Velegraki, Aristea; Mayser, Peter; Bassukas, Ioannis D


    The implication of the yeast genus Malassezia in skin diseases has been characterized by controversy, since the first description of the fungal nature of pityriasis versicolor in 1846 by Eichstedt. This is underscored by the existence of Malassezia yeasts as commensal but also by their implication in diseases with distinct absence of inflammation despite the heavy fungal load (pityriasis versicolor) or with characteristic inflammation (eg, seborrheic dermatitis, atopic dermatitis, folliculitis, or psoriasis). The description of 14 Malassezia species and subsequent worldwide epidemiologic studies did not reveal pathogenic species but rather disease-associated subtypes within species. Emerging evidence demonstrates that the interaction of Malassezia yeasts with the skin is multifaceted and entails constituents of the fungal wall (melanin, lipid cover), enzymes (lipases, phospholipases), and metabolic products (indoles), as well as the cellular components of the epidermis (keratinocytes, dendritic cells, and melanocytes). Understanding the complexity of their interactions will highlight the controversies on the clinical presentation of Malassezia-associated diseases and unravel the complexity of skin homeostatic mechanisms. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. The Ground Zero Mosque Controversy: Implications for American Islam

    Directory of Open Access Journals (Sweden)

    Liyakat Takim


    Full Text Available The controversy surrounding the “ground zero mosque” is part of a larger debate about the place of Islam in U.S. public space. The controversy also reveals the ways in which the boundaries of American identity continue to be debated, often through struggles over who counts as a “real” American. It further demonstrates the extent to which Islam is figured as un-American and militant, and also the extent to which all Muslims are required to account for the actions of those who commit violence under the rubric of Islam. This paper will discuss how, due to the events of September 11, 2001, Muslims have engaged in a process of indigenizing American Islam. It will argue that the Park51 Islamic Community Center (or Ground Zero mosque is a reflection of this indigenization process. It will go on to argue that projects such as the Ground Zero mosque which try to establish Islam as an important part of the American religious landscape and insist on the freedom of worship as stated in the U.S. constitution, illustrate the ideological battlefield over the place of Islam in the U.S. The paper will also examine the possible ramifications of building the Park51 Islamic Community Center including how this will shape the role that Islam plays in the socio-political lives America Muslims.

  6. The nuclear controversy as reflected in the daily press

    International Nuclear Information System (INIS)

    Buiren, S. van.


    Based on a content analysis of 2047 journal articles of the years 1974 to 1977 on conflicts over nuclear power plants (Wyhl, Brokdorf), the book intends to analyze the role of the media in present social conflicts. The book presents facts and figures concerning the information and opinions on nuclear power in five newspapers and the bias of these newspapers in favour of nuclear power or against it. According to the author, newspaper journalists have failed at least in one thing: to explain the dimensions of the conflict with regard to social policy and to give background information on their own opinions. On the other hand, the press has proved its independence: It is not an extended arm of industrial PR departments - at least not in the nuclear controversy. The greater part of the articles is in opposition to nuclear power. The development and modifications of the arguments stated by the various groups active in the nuclear controversy are analyzed in dependence of the increasingly aggressive nature of the conflict. (HP) [de

  7. Endothelial progenitor cell subsets and preeclampsia: Findings and controversies

    Directory of Open Access Journals (Sweden)

    Armin Attar


    Full Text Available Vascular remodeling is an essential component of gestation. Endothelial progenitor cells (EPCs play an important role in the regulation of vascular homeostasis. The results of studies measuring the number of EPCs in normal pregnancies and in preeclampsia have been highly controversial or even contradictory because of some variations in technical issues and different methodologies enumerating three distinct subsets of EPCs: circulating angiogenic cells (CAC, colony forming unit endothelial cells (CFU-ECs, and endothelial colony-forming cells (ECFCs. In general, most studies have shown an increase in the number of CACs in the maternal circulation with a progression in the gestational age in normal pregnancies, while functional capacities measured by CFU-ECs and ECFCs remain intact. In the case of preeclampsia, mobilization of CACs and ECFCs occurs in the peripheral blood of pregnant women, but the functional capacities shown by culture of the derived colony-forming assays (CFU-EC and ECFC assays are altered. Furthermore, the number of all EPC subsets will be reduced in umbilical cord blood in the case of preeclampsia. As EPCs play an important role in the homeostasis of vascular networks, the difference in their frequency and functionality in normal pregnancies and those with preeclampsia can be expected. In this review, there was an attempt to provide a justification for these controversies.

  8. The mesh controversy [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Joshua A. Cohn


    Full Text Available Pelvic organ prolapse and stress urinary incontinence are common conditions for which approximately 11% of women will undergo surgical intervention in their lifetime. The use of vaginal mesh for pelvic organ prolapse and stress urinary incontinence rose rapidly in the early 2000s as over 100 mesh products were introduced into the clinical armamentarium with little regulatory oversight for their use. US Food and Drug Administration Public Health Notifications in 2008 and 2011, as well as reclassification of transvaginal mesh for prolapse to class III in early 2016, were a response to debilitating complications associated with transvaginal mesh placement in many women. The midurethral sling has not been subject to the same reclassification and continues to be endorsed as the “gold standard” for surgical management of stress urinary incontinence by subspecialty societies. However, litigators have not differentiated between mesh for prolapse and mesh for incontinence. As such, all mesh, including that placed for stress urinary incontinence, faces continued controversy amidst an uncertain future. In this article, we review the background of the mesh controversy, recent developments, and the anticipated role of mesh in surgery for prolapse and stress urinary incontinence going forward.

  9. Patients' perspective on controversial issues in total knee arthroplasty. (United States)

    Kim, Tae Kyun; Choi, Jinbae; Shin, Kwang Sook; Chang, Chong Bum; Seong, Sang Cheol


    We investigated the level of patient knowledge and preferences over the currently controversial issues in TKA. One hundred patients who had decided to undergo TKA for advanced osteoarthritis were asked to complete a questionnaire inquiring their knowledge and preferences over three controversial issues: (1) computer assisted surgery (CAS), (2) minimal invasive surgery (MIS), and (3) ceramic femoral component. The patient preferences over the three issues were questioned again after they had been informed of advantages and disadvantages of each option using an explanatory document. Most (more than 75%) of the patients did not have sufficient knowledge and their knowledge was based on non-professional sources (more than 85%). Before the information was given, most (more than 80%) of the patients preferred a new option. After the information was provided, more patients preferred a standard option in the issues of CAS (60%) and MIS (88%). This study prompts health care providers to become more active in providing accurate information and to consider patients perspective in making decisions which will influence the benefits and risk of the patients.

  10. The rocky flats controversy on radionuclide soil action levels

    International Nuclear Information System (INIS)

    Earle, T.C.


    An account of the Rocky Flats radionuclide soil action level controversy is presented as: a case study for the purpose of understanding the nature and value of stakeholder involvement in the management of radiological hazards. The report consists of three main sections. The first section outlines the Rocky Flats story, including the Cold War era, which was characterised by secrecy and distrust, the post-Cold War era, in which trust and co-operation between risk managers and the public began to develop. This contrast between these two historical periods provides the context necessary to understand the radionuclide soil action level controversy, the main events of which are described in the second section. In the final section, the Rocky Flats case is briefly discussed within the framework of a general model of stakeholder involvement and the lessons learned from the case are identified: (1) without a basis in shared values, collaborative public involvement in the management of radiological hazards is not possible; (2) given a basis in shared values, collaborative public involvement can lead to improved solutions to the management of radiological hazards; and (3) risk managers should therefore seek to understand the values of public stakeholders and to identify ways, through stakeholder involvement, that those values can be incorporated in management practice. (author)

  11. Comprehension of Relations among Controversial Texts: Effects of External Strategy Use (United States)

    Kobayashi, Keiichi


    This study examined the effects of external strategy use on the comprehension of relations among controversial texts. About 80 undergraduates read six controversial texts for the purpose of either finding intertextual relations or forming their opinion about the controversial issue. Half of them were permitted to use external strategies, the other…

  12. Controversial aspects of the life cycle of Fasciola hepatica. (United States)

    Moazeni, Mohammad; Ahmadi, Amin


    Fasciola hepatica is a well-known helminth parasite, with significant economic and public health importance all over the world. It has been known since more than 630 years ago and a considerable research work has been carried out on the life cycle of this important parasite. In the hepatic phase of the life cycle of F. hepatica, it is assumed that the young flukes, after about 6-7 weeks of migration in the liver parenchyma, enter into the bile ducts of the definitive hosts and become sexually mature. Even though the secretion of cysteine peptidases including cathepsin L and B proteases by F. hepatica may justify this opinion, because of several scientific reasons and based on the experimental studies conducted in different animals (reviewed in this article), the entry of parasites into the bile ducts, after their migration in the liver parenchyma seems to be doubtful. However, considering all the facts relating to the hepatic and biliary phases of the life cycle of F. hepatica, two alternative ideas are suggested: 1) some of the migrating juvenile flukes may enter into the bile ducts immediately after reaching the liver parenchyma while they are still very small, or 2) when newly excysted juvenile flukes are penetrating into the intestinal wall to reach the liver through the abdominal cavity, a number of these flukes may enter into the choleduct and reach the hepatic bile ducts, where they mature. According to the previously performed natural and experimental studies in different animals and human beings, the supporting and opposing evidences for the current opinion as well as the evidences that might justify the two new ideas are reviewed and discussed briefly. In conclusion, our present knowledge about the time and quality of the entry of F. hepaticas into the bile ducts, seems to be insufficient, therefore, there are still some dark corners and unknown aspects in this field that should be clarified. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Chemistry as the analytical tool in solving the taxonomic controversies of plants (abstract)

    International Nuclear Information System (INIS)

    Din, A.M.U.; Kashmiri, M.A.; Ahmad, S.


    The science of chemical taxonomy is used for the classification of plants on the basis of their chemical constituents which are deeply concerned with the molecular characteristics. Five locally available plant taxa of Solanum nigrum Complex viz.: S. americanum Mill., S. chenopodioides Lam., S. nigrum L., S. retroflexum Dunal and S. villosum Mill. were investigated to resolve the international taxonomic controversy about these plants. Comparative qualitative and quantitative analyses of these plant samples were undertaken keeping Alkaloids, Flavonoids and Epicuticular wax as potential characters. The glycosides of alkaloids and flavonoids were determined by HPLC whereas their aglycones and epicuticular waxes were analysed using GC-MS. HPLC and GC-MS analyses of these constituents from S. nigrum Complex had not been reported previously. Statistical analyses of results grouped taxa into different clusters on the basis of similarity index and Euclidean distance. (author)

  14. Serratia liquefaciens Infection of a Previously Excluded Popliteal Artery Aneurysm

    Directory of Open Access Journals (Sweden)

    A. Coelho

    Full Text Available : Introduction: Popliteal artery aneurysms (PAAs are rare in the general population, but they account for nearly 70% of peripheral arterial aneurysms. There are several possible surgical approaches including exclusion of the aneurysm and bypass grafting, or endoaneurysmorrhaphy and interposition of a prosthetic conduit. The outcomes following the first approach are favorable, but persistent blood flow in the aneurysm sac has been documented in up to one third of patients in the early post-operative setting. Complications from incompletely excluded aneurysms include aneurysm enlargement, local compression symptoms, and sac rupture. Notably infection of a previously excluded and bypassed PAA is rare. This is the third reported case of PAA infection after exclusion and bypass grafting and the first due to Serratia liquefaciens. Methods: Relevant medical data were collected from the hospital database. Results: This case report describes a 54 year old male patient, diagnosed with acute limb ischaemia due to a thrombosed PAA, submitted to emergency surgery with exclusion and venous bypass. A below the knee amputation was necessary 3 months later. Patient follow-up was lost until 7 years following surgical repair, when he was diagnosed with aneurysm sac infection with skin fistulisation. He had recently been diagnosed with alcoholic hepatic cirrhosis Child–Pugh Class B. The patient was successfully treated by aneurysm resection, soft tissue debridement and systemic antibiotics. Conclusion: PAA infection is a rare complication after exclusion and bypass procedures but should be considered in any patient with evidence of local or systemic infection. When a PAA infection is diagnosed, aneurysmectomy, local debridement, and intravenous antibiotic therapy are recommended. The “gold standard” method of PAA repair remains controversial. PAA excision or endoaneurysmorrhaphy avoids complications from incompletely excluded aneurysms, but is associated with

  15. Unitization in Brazil: controversial issues; Unitizacao no Brasil: questoes controversas

    Energy Technology Data Exchange (ETDEWEB)

    Bucheb, Jose Alberto [PETROBRAS, Rio de Janeiro, RJ (Brazil)


    One of the main consequences of the growing number of the tendered blocks is the increasing probability of the discovery of oil and gas accumulations that extends through more than one concession. In these cases, the Brazilian Petroleum Law determines that the concessionaires of the adjoining blocks shall agree on the unitization of the production. In this context, the negotiations of the first agreements have brought some controversies not yet resolved. The first one is related to the instrument that will define the basis of the unitization process in case of non-agreement within the maximum period established by the ANP. Another issue still in discussion relates to the scope of the unitization process: field, block, vertical prism of indeterminate depth, vertical prism of determinate depth or reservoir (accumulation). Additionally, the unitization involving concessions with different local content commitments is analyzed. (author)

  16. Open access and the humanities contexts, controversies and the future

    CERN Document Server

    Eve, Martin Paul


    If you work in a university, you are almost certain to have heard the term 'open access' in the past couple of years. You may also have heard either that it is the utopian answer to all the problems of research dissemination or perhaps that it marks the beginning of an apocalyptic new era of 'pay-to-say' publishing. In this book, Martin Paul Eve sets out the histories, contexts and controversies for open access, specifically in the humanities. Broaching practical elements alongside economic histories, open licensing, monographs and funder policies, this book is a must-read for both those new to ideas about open-access scholarly communications and those with an already keen interest in the latest developments for the humanities.

  17. AMS and controversies in history The Spanish conquest of Peru

    CERN Document Server

    Zoppi, U; Jacobsen, G; Laurencich-Minelli, L; Lawson, E M; Sarkisian, G; Tuniz, C


    The quest for understanding the past often contains a subjective component. Legends, myths, traditions and personal beliefs can unconsciously influence the interpretation of the scientific outcomes or, in the worst instances, even lead to forgery. Fortunately, an increasing number of scientific tools are available nowadays and can be combined to discredit such detriments and offer more reliable foundations for an objective analysis. Radiocarbon dating by AMS is a relatively non-invasive method and is particularly useful when valuable historical artefacts are involved. In this paper, we will present controversial cases where AMS is playing an important role in understanding the past. In particular, we will discuss the use of AMS to authenticate historical documents revealing a new version of the conquest of Peru by Pizarro in the early 1530s.

  18. Ecotheology and the theology of eating: controversies and convergencies

    Directory of Open Access Journals (Sweden)

    Panu Pihkala


    Full Text Available Environmental theology (or, ecotheology developed slowly during the first half of the twentieth century and has become a major field of study since the late 1960s. While many of the issues discussed in ecotheological works have included consequences for food production and eating habits, these themes were often not explicitly discussed. The reasons for this are interesting and complex. Issues related to food have been culturally very sensitive and have manifold connections to religiosity. In regard to the discussion about the rights and value of animals, controversies have been seen to arise between ecotheology and ‘animal theology’. Recently, a new interest has arisen in the themes of food, eating, and Christian theology, which has resulted in a new field of literature which could be called the ‘theology of eating’. This article gives an overview of the relations between these fields, with an emphasis on both early ecotheology and new literature about the theology of eating.

  19. Transrectal Ultrasound Guided Prostate Biopsy: Current Status and Controversy

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sung Il; Lee, Hak Jong; Hong, Sung Kyu; Lee, Sang Eun [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kim, Seung Hyup; Cho, Jeong Yeon [Seoul National University Hospital, Seoul (Korea, Republic of)


    In Korea, the incidence of prostate cancer in 2002 was sixth among the malignancies diagnosed in men, but it was the most rapidly increasing cancer. As many prostate cancers are indistinguishable from normal prostate tissue as determined on an ultrasound examination, the randomized systematic transrectal ultrasound guided prostate biopsy is the gold standard for the detection of prostate cancer. Indications for a TRUS guided prostate biopsy including an elevated level of prostate specific antigen (PSA) and an abnormal digital rectal exam, as well as patient preparation and procedure techniques including anesthesia are reviewed in this report. This report also considers controversies about a prostate biopsy such as the ideal number of biopsy cores, usefulness of PSA derivatives, effective methods for local anesthesia, and the use of patient preparation questionnaires covering topics such as the paucity of anticoagulants and the use of antibiotics and enemas

  20. Articles and contributions to the nuclear controversy - 1

    International Nuclear Information System (INIS)

    Wethe, P.I.


    In the beginning of the 1970s the public interest in nuclear power in Norway was negligible, and an active information campaign might have been interpreted as an attack on the dominant hydroelectric development policy. In 1973 the electricity authorities themselves began to propose concrete nuclear power projects. Over a very short interval of time organised protest groups emerged whose main objective was to hinder the establishment of nuclear power in their own districts. T hese have since developed into agressive national groups and in the period up to the spring of 1975 an intense press debate took place. The staff of Institutt for Atomenergi took an active part in this debate and this collection of articles and contributions gives an impression of the nuclear controversy in Norway from 1973 to 1976. (JIW)

  1. Neural tube defects – recent advances, unsolved questions and controversies (United States)

    Copp, Andrew J.; Stanier, Philip; Greene, Nicholas D. E.


    Neural tube defects (NTDs) are severe congenital malformations affecting around 1 in every 1000 pregnancies. Here we review recent advances and currently unsolved issues in the NTD field. An innovation in clinical management has come from the demonstration that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary prevention by folic acid has been enhanced through introduction of mandatory food fortification in some countries, although not yet in UK. Genetic predisposition comprises the majority of NTD risk, and genes that regulate folate one-carbon metabolism and planar cell polarity have been strongly implicated. The sequence of human neural tube closure events remains controversial, but study of mouse NTD models shows that anencephaly, open spina bifida and craniorachischisis result from failure of primary neurulation, while skin-covered spinal dysraphism results from defective secondary neurulation. Other ‘NTD’ malformations, such as encephalocele, are likely to be post-neurulation disorders. PMID:23790957

  2. Books average previous decade of economic misery. (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios


    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  3. Induced vaginal birth after previous caesarean section

    Directory of Open Access Journals (Sweden)

    Akylbek Tussupkaliyev


    Full Text Available Introduction The rate of operative birth by Caesarean section is constantly rising. In Kazakhstan, it reaches 27 per cent. Research data confirm that the percentage of successful vaginal births after previous Caesarean section is 50–70 per cent. How safe the induction of vaginal birth after Caesarean (VBAC remains unclear. Methodology The studied techniques of labour induction were amniotomy of the foetal bladder with the vulsellum ramus, intravaginal administration of E1 prostaglandin (Misoprostol, and intravenous infusion of Oxytocin-Richter. The assessment of rediness of parturient canals was conducted by Bishop’s score; the labour course was assessed by a partogram. The effectiveness of labour induction techniques was assessed by the number of administered doses, the time of onset of regular labour, the course of labour and the postpartum period and the presence of complications, and the course of the early neonatal period, which implied the assessment of the child’s condition, described in the newborn development record. The foetus was assessed by medical ultrasound and antenatal and intranatal cardiotocography (CTG. Obtained results were analysed with SAS statistical processing software. Results The overall percentage of successful births with intravaginal administration of Misoprostol was 93 per cent (83 of cases. This percentage was higher than in the amniotomy group (relative risk (RR 11.7 and was similar to the oxytocin group (RR 0.83. Amniotomy was effective in 54 per cent (39 of cases, when it induced regular labour. Intravenous oxytocin infusion was effective in 94 per cent (89 of cases. This percentage was higher than that with amniotomy (RR 12.5. Conclusions The success of vaginal delivery after previous Caesarean section can be achieved in almost 70 per cent of cases. At that, labour induction does not decrease this indicator and remains within population boundaries.

  4. Mapping intravascular ultrasound controversies in interventional cardiology practice.

    Directory of Open Access Journals (Sweden)

    David Maresca

    Full Text Available Intravascular ultrasound is a catheter-based imaging modality that was developed to investigate the condition of coronary arteries and assess the vulnerability of coronary atherosclerotic plaques in particular. Since its introduction in the clinic 20 years ago, use of intravascular ultrasound innovation has been relatively limited. Intravascular ultrasound remains a niche technology; its clinical practice did not vastly expand, except in Japan, where intravascular ultrasound is an appraised tool for guiding percutaneous coronary interventions. In this qualitative research study, we follow scholarship on the sociology of innovation in exploring both the current adoption practices and perspectives on the future of intravascular ultrasound. We conducted a survey of biomedical experts with experience in the technology, the practice, and the commercialization of intravascular ultrasound. The collected information enabled us to map intravascular ultrasound controversies as well as to outline the dynamics of the international network of experts that generates intravascular ultrasound innovations and uses intravascular ultrasound technologies. While the technology is praised for its capacity to measure coronary atherosclerotic plaque morphology and is steadily used in clinical research, the lack of demonstrated benefits of intravascular ultrasound guided coronary interventions emerges as the strongest factor that prevents its expansion. Furthermore, most of the controversies identified were external to intravascular ultrasound technology itself, meaning that decision making at the industrial, financial and regulatory levels are likely to determine the future of intravascular ultrasound. In light of opinions from the responding experts', a wider adoption of intravascular ultrasound as a stand-alone imaging modality seems rather uncertain, but the appeal for this technology may be renewed by improving image quality and through combination with

  5. Stimuli previously associated with reinforcement mitigate resurgence. (United States)

    Craig, Andrew R; Browning, Kaitlyn O; Shahan, Timothy A


    Resurgence refers to the recurrence of an extinguished target behavior following subsequent suspension of alternative reinforcement. Delivery of reinforcers during extinction of alternative behavior has been shown to mitigate resurgence. The present experiment aimed to determine whether delivering stimuli associated with reinforcers during resurgence testing similarly mitigates resurgence. Three groups of rats pressed target levers for food according to variable-interval 15-s schedules during Phase 1. In Phase 2, lever pressing was extinguished, and an alternative nose-poke response produced alternative reinforcement according to a variable-interval 15-s schedule. Food reinforcement was always associated with illumination of the food aperture and an audible click from the pellet dispenser during Phases 1 and 2. Phase 3 treatments differed between groups. For one group, nose poking continued to produce food and food-correlated stimuli. Both of these consequences were suspended for a second group. Finally, nose poking produced food-correlated stimuli but not food for a third group. Target-lever pressing resurged in the group that received no consequences and in the group that received only food-correlated stimuli for nose poking. Resurgence, however, was smaller for the group that received food-correlated stimuli than for the group that received no consequences for nose poking. Target-lever pressing did not increase between phases in the group that continued to receive food and associated stimuli. Thus, delivery of stimuli associated with food reinforcement after suspension of food reduced but did not eliminate resurgence of extinguished lever pressing. These findings contribute to potential methodologies for preventing relapse of extinguished problem behavior in clinical settings. © 2017 Society for the Experimental Analysis of Behavior.

  6. The angular momentum controversy: What’s it all about and does it matter?

    International Nuclear Information System (INIS)

    Leader, Elliot; Lorcé, Cédric


    The general question, crucial to an understanding of the internal structure of the nucleon, of how to split the total angular momentum of a photon or gluon into spin and orbital contributions is one of the most important and interesting challenges faced by gauge theories like Quantum Electrodynamics and Quantum Chromodynamics. This is particularly challenging since all QED textbooks state that such a splitting cannot be done for a photon (and a fortiori for a gluon) in a gauge-invariant way, yet experimentalists around the world are engaged in measuring what they believe is the gluon spin! This question has been a subject of intense debate and controversy, ever since, in 2008, it was claimed that such a gauge-invariant split was, in fact, possible. We explain in what sense this claim is true and how it turns out that one of the main problems is that such a decomposition is not unique and therefore raises the question of what is the most natural or physical choice. The essential requirement of measurability does not solve the ambiguities and leads us to the conclusion that the choice of a particular decomposition is essentially a matter of taste and convenience. In this review, we provide a pedagogical introduction to the question of angular momentum decomposition in a gauge theory, present the main relevant decompositions and discuss in detail several aspects of the controversies regarding the question of gauge invariance, frame dependence, uniqueness and measurability. We stress the physical implications of the recent developments and collect into a separate section all the sum rules and relations which we think experimentally relevant. We hope that such a review will make the matter amenable to a broader community and will help to clarify the present situation

  7. The LNT-controversy and the concept of "controllable dose". (United States)

    Kellerer, A M; Nekolla, E A


    There is no firm scientific information on the potential health effects, such as increased cancer rates, due to low doses of ionizing radiation. In view of this uncertainty ICRP has adopted as a prudent default option the linear no-threshold (LNT) assumption and has used it to derive nominal risk coefficients. Subsequent steps, such as the comparison of putative fatality rates in radiation workers with observed accident rates in other professions, have given the risk estimates a false appearance of scientific fact. This has encouraged meaningless computations of radiation-induced fatalities in large populations and has caused a trend to measure dose limits for the public not against the magnitude of the natural radiation exposure and its geographic variations, but against the numerical risk estimates. In reaction to this development, opposing claims are being made of a threshold in dose for deleterious health effects in humans. In view of the growing polarization, ICRP is now exploring a new concept "controllable dose" that aims to abandon the quantity collective dose, emphasizing, instead, individual dose and, in particular, the control of the maximum individual dose from single sources. Essential features of the new proposal are here examined, and it is concluded that the control of individual dose will still have to be accompanied by the avoidance of unnecessary exposures of large populations, even if their magnitude lies below that acceptable to the individual. If a reasonable cut-off at trivial doses is made, the collective dose can remain useful. Misapplications of collective dose are not the deeper cause of the current controversy; the actual root is the misrepresentation of the LNT-assumption as a scientific fact and the amplification of this confusion by loose terminology. If over-interpretation and distortion are avoided, the current system of radiation protection is workable and essentially sound, and there is no need for a fruitless LNT-controversy. The

  8. Attitude of medical professionals regarding controversial issues in kidney donation/transplantation

    Directory of Open Access Journals (Sweden)

    N Almeida


    Full Text Available There is a dire need to evaluate new strategies to bridge the wide kidney demand-supply gap. The current study examined the attitude of medical professionals regarding controversial issues pertaining to transplantation. A questionnaire, presenting controversial issues related to kidney transplantation, in an agree-disagree format with supporting reasons, was employed. The research was exploratory. Data were analyzed quantitatively and qualitatively. The sample comprised 140 doctors from Mumbai (mean = 38.1 years, standard deviation = 17.95; Males = 44.3%, Females = 55.7%. Whereas 47.1% of the participants felt that live donors should be given incentives for kidney donation, others (52.9% disagreed, fearing commercialization and illegal activities. The eligibility of patients with HIV/hepatitis for a transplant was denied by 52.9% because of poor outcomes, with the others (47.1% maintaining that these individuals too had a right to live. A substantial majority (90.7% of the participants maintained that organ donors should be given priority in the event of a future need for an organ because their previous humane act should be rewarded (47.1%. Most of the participants (91.4% felt that individuals from the higher socioeconomic strata should not receive preference for kidney transplantation. A majority (77.1% of them were also against kidney selling getting legalized. Compulsory possession of a donor card elicited mixed responses, with some accepting (56.4%, but others rejecting (43.6% this idea as donation was perceived to be a voluntary act (33.6%. While compulsory kidney donation found favor with 44.3%, it found disfavor with others (55.7%. This study will benefit transplant healthcare personnel to formulate new policies in relation to kidney donation/transplantation.

  9. Views and controversies on physical punishments in education ...

    African Journals Online (AJOL)

    Being a review of a previous work, the present article attempts to demonstrate the extent to which a range of educators express their views on physical punishments, a practice that is increasingly contested and forbidden by many education stakeholders since the previous decades. Through analysis of different declarations ...

  10. Sensory processing disorders – diagnostic and therapeutic controversies

    Directory of Open Access Journals (Sweden)

    Aneta R. Borkowska


    Full Text Available This article presents the current state of knowledge regarding the controversial issue of sensory integration dysfunction/sensory processing disorder. Symptoms are defined as impairments in the accurate reception and registering of stimuli, differentiation of stimulus intensity, and adequate reactivity to stimulation. They can be of specific character and occur in isolation and can also be a nonspecific element of a clinical picture of another disease entity. Psychophysiological and neuroimaging studies confirm the existence of both a distinct group of children with symptoms of sensory processing disorder diagnosed based on descriptions of behaviours listed in questionnaires and of a specific neurobiological basis of this disorder. In clinical practice, it is of key importance to determine whether behavioural problems observed in children are caused by disorders other than sensory processing disorders. Results of meta-analyses regarding sensory integration therapy are inconclusive and do not allow this form of treatment to be considered fact-based. Future studies with high methodological standards are necessary in order to verify the effectiveness of different forms of sensory integration therapy. Parents should be informed about the existing limitations.

  11. Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues. (United States)

    Russo, Ethan B


    This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements for production of cannabis-based medicines, particularly the Food and Drug Administration "Botanical Guidance." The remainder pertains to various cannabis controversies that certainly require closer examination if the scientific, consumer, and governmental stakeholders are ever to reach consensus on safety issues, specifically: whether botanical cannabis displays herbal synergy of its components, pharmacokinetics of cannabis and dose titration, whether cannabis medicines produce cyclo-oxygenase inhibition, cannabis-drug interactions, and cytochrome P450 issues, whether cannabis randomized clinical trials are properly blinded, combatting the placebo effect in those trials via new approaches, the drug abuse liability (DAL) of cannabis-based medicines and their regulatory scheduling, their effects on cognitive function and psychiatric sequelae, immunological effects, cannabis and driving safety, youth usage, issues related to cannabis smoking and vaporization, cannabis concentrates and vape-pens, and laboratory analysis for contamination with bacteria and heavy metals. Finally, the issue of pesticide usage on cannabis crops is addressed. New and disturbing data on pesticide residues in legal cannabis products in Washington State are presented with the observation of an 84.6% contamination rate including potentially neurotoxic and carcinogenic agents. With ongoing developments in legalization of cannabis in medical and recreational settings, numerous scientific, safety, and public health issues remain.

  12. Unwaged Posts in UK Universities: Controversies and Campaigns

    Directory of Open Access Journals (Sweden)

    Kirsten Forkert


    Full Text Available This article examines unwaged posts at UK universities, using recent examples of advertised job posts. While unpaid work is common in the UK higher education system, unwaged posts are not. The posts under scrutiny in this article differ from traditional honorary titles as they target early career academics, who are unlikely to have a paid position elsewhere, rather than established scholars. The article contextualizes the appearance of these posts in a climate of increasing marketization of higher education, entrenching managerialism in higher education institutions, and the casualization of academic work. We also discuss resistance to the posts, arguing that the controversy surrounding unpaid internships in the creative industries created a receptive environment for resisting unwaged posts in academia. We analyze the campaigns that were fought against the advertisement of the posts, mostly through social media and the University and College Union. We explore the tactics used and discuss the advantages and limitations of the use of social media, as well as the role of trade unions in the campaigns against these posts, and we reflect on what future campaigns can learn from these experiences.

  13. Sustainable Development? Controversies over Prawn Farming on Mafia Island, Tanzania

    Directory of Open Access Journals (Sweden)

    Pat Caplan


    Full Text Available The world market for crustaceans has increased exponentially in recent years and so too have the number of production sites. However, the growth of this industry has not been without controversy, particularly regarding its environmental effects. In 2002, a large company based in Kenya applied to locate a prawn farm on Mafia Island, Tanzania, close to the Rufiji Delta. This scheme raised very differing views among various 'stakeholders': villagers living around the proposed site, the Mafia District Councillors (madiwan, government officials at varying levels, local and national activists (some in NGOs, the prawn farming company, and the experts whom they hired to produce environmental impact reports. There were opposing discourses around the rights of locals as citizens to retain control of 'their' resources, on the one hand, versus the needs of 'development' and the creation of jobs, on the other. There were also fierce debates about the importance and meaning of environment and sustainability, and the perceived role of corruption. This paper, based on fieldwork in 2002 and 2004, explores these complex debates and the ways in which the decision was finally made to allow the prawn farm to go ahead. It reveals the means by which the legal rights of citizens at the local level may be trumped by pressures emanating from those coming from above and outside who wield greater power.

  14. Zollinger-Ellison syndrome: classical considerations and current controversies. (United States)

    Epelboym, Irene; Mazeh, Haggi


    Zollinger-Ellison syndrome (ZES) is an endocrinopathy characterized by gastrin-secreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Two main variants have been described, sporadic and those found in association with parathyroid and pituitary tumors, a genetic disorder known as multiple endocrine neoplasia-1 (MEN-1). Biochemical serum evaluation for elevated gastrin, followed by radiological or nuclear localization of the primary lesion, is mandated for establishing diagnosis. The mainstays of treatment include management of hypersecretory state with medical suppression of gastric acid production and surgical resection of primary tumor for the prevention of malignant transformation and metastatic complications. Medical therapy with proton pump inhibitors has virtually eliminated the need for acid-reducing surgical procedures. Surgical approach to sporadic and MEN-1-associated ZES varies based on our understanding of the natural history of the condition and the probability of cure; however, resection to a negative microscopic margin is indicated in both cases. Postoperative surveillance involves measurement of gastrin level, followed by imaging if elevation is detected. Re-excision of recurrent or resection of metastatic disease is a subject of controversy; however, at the present time aggressive cytoreductive approach is favored.

  15. Understanding the nuclear controversy: An application of cultural theory

    International Nuclear Information System (INIS)

    Graaff, Shashi van de


    The need for a secure and sustainable energy future has become firmly entrenched on the global political agenda. Governments worldwide are seeking solutions that will ensure security of their energy supplies, while reducing carbon emissions in the fight against climate change. Advocates of nuclear power have reframed the technology as the most reliable, cost-effective and immediate solution to both of these policy problems, and predicted the emergence of a 'nuclear renaissance’. However, there is little evidence to date that suggests a nuclear renaissance has actually taken place. Public opinion polling demonstrates that many remain unconvinced of the need for nuclear power. This paper uses Cultural Theory as a heuristic to understand why the arguments for a nuclear renaissance have been largely unsuccessful. It argues that the failure of nuclear advocates to engage with a wider cross-section of world-views has prevented the controversy surrounding nuclear power from being resolved, and the nuclear renaissance from becoming a reality. In doing so, this paper builds upon a growing recognition of the contribution that social science research can make to understanding public acceptance of energy policy choices. - Highlights: • There is little evidence of a nuclear renaissance taking place in Western Europe or North America. • Public opinion on nuclear power continues to be deeply divided. • Pro-nuclear arguments are dominated by a particular cultural rationality. • A broader range of cultural perspectives needs to be recognised for the nuclear debate to progress.

  16. Controversies, development and trends of biofuel industry in the world

    Directory of Open Access Journals (Sweden)

    WenJun Zhang


    Full Text Available Controversies, development and trends of biofuel industry in the world were discussed in present article. First-generation biofuels, i.e., grain and land based biofuels, occupied large areas of arable lands and severely constrained food supplies, are widely disputed. They have been replaced by second-generation biofuels. The raw materials of the second-generation biofuels include plants, straw, grass and other crops and forest residues. However, the cost for production of the second-generation biofuels is higher. Therefore the development of the third-generation biofuels is undergoing. The third-generation technologies use, mainly algae, as raw material to produce bioethanol, biobutanol, biodiesel and hydrogen, and use discarded fruits to produce dimethylfuran, etc. Different countries and regions are experiencing different stages of biofuel industry. In the future the raw materials for biofuel production will be focused on various by-products, wastes, and organisms that have not direct economic benefit for human. Production technologies should be improved or invented to reduce carbon emission and environmental pollution during biofuel production and to reduce production cost.

  17. The Soul in Medicine: Rabbinic and Scientific Controversies. (United States)

    Zukier, Henri


    The practice of medicine relies on a combination of two very different sources, and requires two kinds of talents: a cognitive-instrumental, knowledge-based and disease-centered approach; and a psychological, expressive-relational and patient-centered approach. Throughout the centuries, the mix between the cognitive and expressive dimensions, and the relative emphasis given to each approach, has varied considerably. Current evidence-based medicine privileges the cognitive-performative dimension. The recent developments within medicine are indicative of the inherent and lasting tension between the cognitive and expressive dimensions. Not surprisingly, then, related terms of debate are also apparent in medieval rabbinic discussions of medical practice. However, the rabbinic and medical traditions resolved the tension in very different ways. This paper explores a conceptual link between the modern dynamics of the cognitive and the socio-relational dimensions, and a complementary rabbinic controversy starting in the thirteenth century, originally between Maimonides and Nahmanides, both physicians. There are significant interactions between the modern evolution in the roles of doctors and patients, and the rabbinic approaches to physicians and illness. The mapping of the two debates about doctors and patients suggests that the tension between science and soul, and the dynamics of integrating them, has characterized medicine through the ages, though they can lead to different outcomes.

  18. Is alveolar cleft reconstruction still controversial? (Review of literature

    Directory of Open Access Journals (Sweden)

    Sameh A. Seifeldin


    Full Text Available Cleft lip and palate (CL/P is a frequent congenital malformation that manifests in several varieties including unilateral or bilateral and complete or incomplete. Alveolar cleft reconstruction remains controversial with regard to timing, graft materials, surgical techniques, and methods of evaluation. Many studies have been conducted addressing these points to develop an acceptable universal protocol for managing CL/P. The primary goal of alveolar cleft reconstruction in CL/P patients is to provide a bony bridge at the cleft site that allows maxillary arch continuity, oronasal fistula repair, eruption of the permanent dentition into the newly formed bone, enhances nasal symmetry through providing alar base support, orthodontic movement and placement of osseointegrated implants when indicated. Other goals include improving speech, improvement of periodontal conditions, establishing better oral hygiene, and limiting growth disturbances. In order to rehabilitate oral function in CL/P patients alveolar bone grafting is necessary. Secondary bone grafting is the most widely accepted method for treating alveolar clefts. Autogenous bone graft is the primary source for reconstructing alveolar cleft defects and is currently the preferred grafting material.

  19. Controversies in multiple myeloma: Evidence-based update. (United States)

    Ahn, Inhye E; Mailankody, Sham


    The US Food and Drug Administration (FDA) approved 10 new drugs for the treatment of multiple myeloma (MM) over the last two decades. The influx of new anti-myeloma agents with high efficacy and acceptable tolerability add complexity to the clinical decision-making process. First, treatment of smoldering multiple myeloma (SMM) remains investigational to date, although a randomized trial showed a survival gain in high-risk patients receiving lenalidomide. Second, in newly diagnosed MM, the majority of contemporary induction regimens have been studied in single-arm trials or compared to an older regimen, which complicates evidence-based treatment selection. Third, the role of consolidation chemotherapy followed by autologous stem cell transplant (ASCT) needs to be revisited in the context of highly effective agents, as newer regimens- such as carfilzomib, lenalidomide, and dexamethasone-are able to achieve extremely deep responses equivalent to or exceeding those seen after conventional induction and ASCT. Fourth, risks and benefits of maintenance therapy should also be redefined and individualized, as long-term survival and safety data accumulate. Here we selected four clinical settings where controversies exist, reviewed evidences behind conflicting treatment strategies, and asked myeloma experts to discuss evidence-based recommendations. Copyright © 2016 Elsevier. All rights reserved.

  20. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies

    Directory of Open Access Journals (Sweden)

    Anna Lubkowska


    Full Text Available The literature reports indicating a link between plasma levels of adiponectin and body fat, bone mineral density, sex hormones, and peri- and postmenopausal changes, draw attention to the possible use of adiponectin as an indicator of osteoporotic changes, suggesting that adiponectin may also modulate bone metabolism. In this study, we attempted to analyze the available in vitro and in vivo results which could verify this hypothesis. Although several studies have shown that adiponectin has an adverse effect on bone mass, mainly by intensifying resorption, this peptide has also been demonstrated to increase the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and reduce bone resorption. There are still many ambiguities; for example, it can be assumed that concentrations of adiponectin in plasma do not satisfactorily reflect its production by adipose tissue, as well as conflicting in vitro and in vivo results. It seems that the potential benefit in the treatment of patients with osteoporosis associated with the pharmacological regulation of adiponectin is controversial.


    Directory of Open Access Journals (Sweden)



    Full Text Available The development of technology in recent decades has forced the transition from the industrialized society, where the main role was occupied by tangible assets, to an information society, where the essential place is played by intangible assets. These are assets that can not be touched or felt, but are very important to produce wealth and to maintain competitiveness. Within these, development expenditure occupies an important place because it influences the analysis of an entity and its future. The accounting practices applicable to development expenditure are based on theoretical fundamentals and ambiguous typologies. The purpose of the article is to present the controversies about recognizing and evaluating development expenditure. Although development expenditure involves large initial investments, it generates, on medium and long term, significant savings. Depending on the purpose for which it is carried out, research and development expenditure can in time generate identifiable intangible assets but also intangible unidentifiable assets. An optimistic attitude regarding the chances of success of a development project will lead to the capitalization of development expenditure. Capitalizing development expenditures, the usefulness of financial statements is increased, which is generally measured in the ability to explain stock prices through earnings and accounting values.

  2. Three controversies over item disclosure in medical licensure examinations

    Directory of Open Access Journals (Sweden)

    Yoon Soo Park


    Full Text Available In response to views on public's right to know, there is growing attention to item disclosure – release of items, answer keys, and performance data to the public – in medical licensure examinations and their potential impact on the test's ability to measure competence and select qualified candidates. Recent debates on this issue have sparked legislative action internationally, including South Korea, with prior discussions among North American countries dating over three decades. The purpose of this study is to identify and analyze three issues associated with item disclosure in medical licensure examinations – 1 fairness and validity, 2 impact on passing levels, and 3 utility of item disclosure – by synthesizing existing literature in relation to standards in testing. Historically, the controversy over item disclosure has centered on fairness and validity. Proponents of item disclosure stress test takers’ right to know, while opponents argue from a validity perspective. Item disclosure may bias item characteristics, such as difficulty and discrimination, and has consequences on setting passing levels. To date, there has been limited research on the utility of item disclosure for large scale testing. These issues requires ongoing and careful consideration.

  3. [Parental alienation and the controversy surrounding psychiatric diagnostics]. (United States)

    Migchels, C; De Wachter, D

    The phenomenon of parental alienation can arise when a child allies with one parent and refuses to have contact with the other parent. The concept has attracted a great deal of attention over the last few years. There has been controversy about whether parental alienation should be recognised as a psychiatric syndrome of the alienated child caught up in a conflict between supporters and opponents. AIM: To try to determine whether parental alienation belongs to psychiatric diagnostics. METHOD: We made a careful study of various databases in order to find literature relating to parental alienation. RESULTS: Parental alienation is situated on the border between psychiatry, sociology and justice. One of the main tasks of psychiatry in this border area is to safeguard the domain of diagnostics. CONCLUSION: Because so much attention is being given to the question of whether parental alienation syndrome should be recognised as a diagnosis, there is often a tendency to ignore the possible impact of parental alienation and to pay very little attention to ways of coping with the problem.

  4. Outbreaks associated with duodenoscopes: new challenges and controversies. (United States)

    Rubin, Zachary A; Murthy, Rekha K


    Recent outbreaks of carbapenem-resistant enterobacteriaceae related to duodenoscopes in the United States and Europe have gained international attention and resulted in new regulations, especially in the United States, affecting healthcare facilities. In this review, we summarize findings from recent duodenoscope-related outbreaks, highlight what is known about the risk of transmission from these devices and discuss controversies about current recommendations to prevent transmission. Between 2013 and 2015, several US and European healthcare facilities reported outbreaks of carbapenem-resistant enterobacteriaceae associated with endoscopic retrograde cholangiopancreatography procedures. Unlike prior outbreaks (attributed to lapses in cleaning and reprocessing), the recent outbreaks occurred in spite of adherence to current reprocessing guidelines. Factors associated with infection transmission include a low margin of safety for gastrointestinal endoscopic procedures and complex design features of duodenoscopes. Outbreaks were halted with enhanced cleaning and surveillance measures or by adopting gas sterilization methods. New guidance from manufacturers and federal agencies has been issued as a result of these recent outbreaks; however, concerns remain that the new measures may not eliminate risks to patients. Recent duodenoscope-related outbreaks have highlighted the need for a reassessment of current guidelines for endoscope reprocessing and for new design of duodenoscope components. Although we summarize the US experience, this review has global implications for the safe cleaning and disinfection of these instruments.

  5. Roles of glucocorticoids in human parturition: a controversial fact? (United States)

    Li, X Q; Zhu, P; Myatt, L; Sun, K


    The pivotal role of glucocorticoids in the initiation of parturition has been very well documented in several domestic mammalian animal species. However the role of glucocorticoids in human parturition remains controversial mainly because of the absence of effect of synthetic glucocorticoids, given to promote fetal organ maturation in pregnant women with threatened preterm delivery, on the length of gestation. This article will review studies of glucocorticoids in human parturition and provide evidence for an important role of glucocorticoids in human parturition as well but a simultaneous high concentration of estrogen within the intrauterine tissues may be necessary for GCs to initiate parturition. The synthetic GCs dexamethasone and betamethasone pass through the placenta intact resulting in potent negative feedback on the fetal HPA axis and diminished production of DHEA from fetal adrenal glands for estrogen synthesis by the placenta. This may negate the effect of systemic administration of GCs on the induction of labor, especially in cases where the myometrium is not yet fully primed by estrogen. Endogenous glucocorticoids are inactivated by the placental 11β-HSD2 thus limiting the negative feedback of maternal cortisol on the fetal HPA axis and allowing the simultaneous rise of cortisol and estrogen levels towards the end of gestation. Therefore, endogenous glucocorticoids, particularly glucocorticoids produced locally in the intrauterine tissues may play an important role in parturition in humans by enhancing prostaglandin production in the fetal membranes and stimulating estrogen and CRH production in the placenta. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Vaccine safety controversies and the future of vaccination programs. (United States)

    François, Guido; Duclos, Philippe; Margolis, Harold; Lavanchy, Daniel; Siegrist, Claire-Anne; Meheus, André; Lambert, Paul-Henri; Emiroğlu, Nedret; Badur, Selim; Van Damme, Pierre


    In the years following the hepatitis B vaccination/multiple sclerosis controversy, a number of new issues regarding vaccine safety have been raised, in some cases leading to more debate and confusion. Against this background, an international group of experts was convened to review the current points of view concerning the use of thimerosal as a preservative and its potential risks; the suggested link between thimerosal-containing vaccines and acute lymphoblastic leukemia; the alleged association between aluminum-containing vaccines/macrophagic myofasciitis and general systemic complaints; a possible link between vaccination and autoimmune pathology; and a hypothetical link between measles-mumps-rubella vaccination and autism. At present, there are no data to conclude that childhood vaccines, and in particular hepatitis B vaccine, pose a serious health risk or justify a change in current immunization practice. However, vaccine "scares" continue to have an international impact on immunization coverage. Creating a positive environment for immunization can be achieved by repositioning the value of vaccines and vaccination, supported by evidence-based information. The role of international organizations, the media, and the industry in the implementation of communication strategies was discussed and the impact of litigation issues on vaccination was evaluated. The Viral Hepatitis Prevention Board confirms its commitment to current recommendations for universal and risk group hepatitis B vaccination and further encourages the conduct of vaccine safety studies and the dissemination of their results.

  7. Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues (United States)

    Russo, Ethan B.


    This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements for production of cannabis-based medicines, particularly the Food and Drug Administration “Botanical Guidance.” The remainder pertains to various cannabis controversies that certainly require closer examination if the scientific, consumer, and governmental stakeholders are ever to reach consensus on safety issues, specifically: whether botanical cannabis displays herbal synergy of its components, pharmacokinetics of cannabis and dose titration, whether cannabis medicines produce cyclo-oxygenase inhibition, cannabis-drug interactions, and cytochrome P450 issues, whether cannabis randomized clinical trials are properly blinded, combatting the placebo effect in those trials via new approaches, the drug abuse liability (DAL) of cannabis-based medicines and their regulatory scheduling, their effects on cognitive function and psychiatric sequelae, immunological effects, cannabis and driving safety, youth usage, issues related to cannabis smoking and vaporization, cannabis concentrates and vape-pens, and laboratory analysis for contamination with bacteria and heavy metals. Finally, the issue of pesticide usage on cannabis crops is addressed. New and disturbing data on pesticide residues in legal cannabis products in Washington State are presented with the observation of an 84.6% contamination rate including potentially neurotoxic and carcinogenic agents. With ongoing developments in legalization of cannabis in medical and recreational settings, numerous scientific, safety, and public health issues remain. PMID:27683558

  8. Gender dysphoria and the controversy over the Safe Schools program. (United States)

    Parkinson, Patrick


    The Safe Schools program has attracted great controversy. On one end of the spectrum, it is defended as an anti-bullying program for young people who identify themselves as gay or lesbian, or have issues concerning their gender identity. On the other end of the spectrum, it is regarded as social engineering. This article seeks to promote a discussion of the way in which gender identity issues are addressed in the Safe Schools program. It is argued that the information in this program to Principals, teachers and young people is inaccurate and misleading. The program, as presently designed, may actually cause harm to children and young people who experience gender identity issues because it promotes gender transitioning without expert medical advice. The Safe Schools materials do not acknowledge that the great majority of children resolve gender dysphoria issues around the time of puberty. It may be much more difficult for a child to accept his or her gender at puberty if he or she has already changed name and gender identity in primary school. These deficits need to be addressed if the program is to continue.

  9. Cannabis Controversies: How genetics can inform the study of comorbidity (United States)

    Agrawal, Arpana; Lynskey, Michael T.


    Aims To review three key and controversial comorbidities of cannabis use – other illicit drug use, psychosis and depression as well as suicide, from a genetically informed perspective. Design Selective review. Results Genetic factors play a critical role in the association between cannabis use, particularly early-onset use and use of other illicit drugs, psychosis and depression as well as suicide, albeit via differing mechanisms. For other illicit drugs, while there is strong evidence for shared genetic influences, residual association that is attributable to causal or person-specific environmental factors cannot be ruled out. For depression, common genetic influences are solely responsible for the association with cannabis use but for suicidal attempt, evidence for person-specific factors persists. Finally, even though rates of cannabis use are inordinately high in those with psychotic disorders, there is no evidence of shared genetic etiologies underlying this comorbidity. Instead, there is limited evidence that adolescent cannabis use might moderate the extent to which diathesis influences psychosis. Conclusions Overlapping genetic influences underlie the association between early-onset cannabis use and other illicit drug use as well as depression and suicide. For psychosis, mechanisms other than shared genetic influences might be at play. PMID:24438181

  10. Controversies and challenges in the management of chronic urticaria. (United States)

    Staubach, P; Zuberbier, T; Vestergaard, C; Siebenhaar, F; Toubi, E; Sussman, G


    This supplement reports proceedings of the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. Despite the clear international guideline, there remain a number of controversies and challenges in the management of patients with chronic urticaria (CU). As a result of major advancements in urticaria over the past 4 years, the current EAACI/GA(2) LEN/EDF/WAO urticaria guideline treatment algorithm requires updating. Case studies from patients with chronic spontaneous urticaria (CSU) [also called chronic idiopathic urticaria (CIU)], chronic inducible urticaria (CIndU) or diseases and syndromes related to CU are useful in describing and exploring challenges in disease management. Case studies of specific CSU patient populations such as children with CU or patients with angio-edema but no hives also require consideration as potentially challenging groups with unmet needs. The current EAACI/GA(2) LEN/EDF/WAO urticaria guideline provides a general framework for the management of patients with CU but, as these cases highlight, a personalized approach based on the expert knowledge of the physician may be required. © 2016 European Academy of Dermatology and Venereology.

  11. The Europeanisation of Austria: Misfit, Adaptation and Controversies

    Directory of Open Access Journals (Sweden)

    Gerda Falkner


    Full Text Available This article analyses the multiple dimensions of Austria’s Europeanisation and the high degree of both misfit and conflict involved therein. Austria’s path to EU membership was characterised by fundamental doubts due to the country’s status of neutrality, and by a basic reinterpretation of this concept. After accession, need for institutional adaptation to the EU’s decision-making patterns was significant since major tenets of the Austrian political system are special. Furthermore, policy misfit between the domestic and the EU level was considerable in several fields, among them highly symbolic ones. Austria’s EU-related diplomacy recently witnessed a major crisis with the other 14 member states ‘sanctioning’ the new centre-right government in a controversial way. Against this background of strong and multi-dimensional misfit, Austrian performance in implementing EU law is still surprisingly good. By contrast, public appreciation of EU membership has declined even further, and a majority of Austrians oppose enlargement while the Freedom Party advocates a referendum on that issue. Therefore, the conclusions argue that improved communication processes and mutual learning across the multiple levels of the EU system are crucial.

  12. The Europeanisation of Austria: Misfit, Adaptation and Controversies

    Directory of Open Access Journals (Sweden)

    Gerda Falkner


    Full Text Available This article analyses the multiple dimensions of Austrias Europeanisation and the high degree of both misfit and conflict involved therein. Austrias path to EU membership was characterised by fundamental doubts due to the countrys status of neutrality, and by a basic reinterpretation of this concept. After accession, need for institutional adaptation to the EUs decision-making patterns was significant since major tenets of the Austrian political system are special. Furthermore, policy misfit between the domestic and the EU level was considerable in several fields, among them highly symbolic ones. Austrias EU-related diplomacy recently witnessed a major crisis with the other 14 member states sanctioning the new centre-right government in a controversial way. Against this background of strong and multi-dimensional misfit, Austrian performance in implementing EU law is still surprisingly good. By contrast, public appreciation of EU membership has declined even further, and a majority of Austrians oppose enlargement while the Freedom Party advocates a referendum on that issue. Therefore, the conclusions argue that improved communication processes and mutual learning across the multiple levels of the EU system are crucial.

  13. Asbestos and cancer: epidemiological and public health controversies. (United States)

    Huncharek, M


    This paper discusses many of the currently controversial issues surrounding asbestos health effects and their relationship to cancer risk assessment and risk management. The major conclusions reached from this analysis are: (1) All asbestos fiber types are carcinogenic and pose a threat to human health. Therefore, all fiber types should be regulated similarly. (2) The health risks associated with indoor asbestos exposure are uncertain. Available data show that some groups, such as building maintenance personnel (among others), may contract asbestos-related diseases secondary to indoor exposure. Clearly, additional research is needed to accurately determine the extent and nature of disease risk under these conditions. (3) Controlled use has proved an elusive goal. Limited information from underdeveloped countries parallels the experience of Western industrialized nations. Efforts by the Canadian government to establish markets for asbestos in these areas should be opposed. (4) Finally, asbestos-related cancer risk is no longer confined to asbestos industry workers. Asbestos-related mesothelioma has been documented in a wide variety of occupational and nonoccupational settings, highlighting the need for continued surveillance to minimize potential health risks.

  14. Maternal obesity and inflammatory mediators: A controversial association. (United States)

    Pendeloski, Karen Priscilla Tezotto; Ono, Erika; Torloni, Maria Regina; Mattar, Rosiane; Daher, Silvia


    The link between maternal obesity and inflammatory mediators is still unclear. Our aim was to summarize the main findings of recently published studies on this topic. We performed a search in Medline for studies published in the last years on obesity, human pregnancy, and inflammatory mediators. We report the findings of 30 studies. The characteristics and number of participants, study design, gestational age at sample collection, and type of sample varied widely. Approximately two-thirds of them investigated more than one mediator, and 50% included participants in only one trimester of pregnancy. The most frequently investigated mediators were leptin, tumour necrosis factor-alpha (TNF-α), and interleukin (IL)-6. Almost all studies reported an association between maternal obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1β and IL-10. The association of IL-6, TNF-α, monocyte chemo-attractant protein-1 (MCP-1), adiponectin, and resistin with maternal obesity is still controversial. To clarify the physiopathological link between maternal obesity and inflammation, more high-quality studies are needed. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Cord blood banking and transplantation: advances and controversies. (United States)

    Yoder, Mervin C


    A review of articles published since January 2012 on the topic of cord blood banking and cord blood stem cell transplantation was conducted for this the 25th anniversary year of the first cord blood transplant performed in a human. Cord blood banking is performed throughout the world. Umbilical cord blood (UCB) transplantation is recognized as an acceptable alternative stem cell source for paediatric and adults requiring a haematopoietic transplant, particularly for patients of racial and ethnic minorities. To further advance the use of UCB, methods to enhance UCB stem cell expansion, engraftment and maintenance may be required. Controversy on the most effective and economically sustainable model for banking and storing an optimal UCB product continues to persist. Cord blood banking and transplantation of cord blood stem cells has advanced rapidly over the initial 25 years, as more than 30 ,000 patients have benefited from the therapy. New concepts on the use of methods to expand UCB stem cells for transplantation and use for nonhaematopoietic indications may increase demand for UCB over the next few decades.

  16. LNT-an apparent rather than a real controversy?

    Energy Technology Data Exchange (ETDEWEB)

    Charles, M W [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)


    Can the carcinogenic risks of radiation that are observed at high doses be extrapolated to low doses? This question has been debated through the whole professional life of the author-now nearing four decades. In its extreme form the question relates to a particular hypothesis (LNT) used widely by the international community for radiological protection applications. The linear no-threshold (LNT) hypothesis propounds that the extrapolation is linear and that it extends down to zero dose. The debate on the validity of LNT has increased dramatically in recent years. This is in no small part due to concern that exaggerated risks at low doses leads to undue amounts of societal resources being used to reduce man-made human exposure and because of the related growing public aversion to diagnostic and therapeutic medical exposures. The debate appears to be entering a new phase. There is a growing realisation of the limitations of fundamental data and the scientific approach to address this question at low doses. There also appears to be an increasing awareness that the assumptions necessary for a workable and acceptable system of radiological protection at low doses must necessarily be based on considerable pragmatism. Recent developments are reviewed and a historical perspective is given on the general nature of controversies in radiation protection over the years. All the protagonists in the debate will at the end of the day probably be able to claim that they were right{exclamation_point} (opinion)

  17. Cannabis controversies: how genetics can inform the study of comorbidity. (United States)

    Agrawal, Arpana; Lynskey, Michael T


    To review three key and controversial comorbidities of cannabis use-other illicit drug use, psychosis and depression, as well as suicide, from a genetically informed perspective. Selective review. Genetic factors play a critical role in the association between cannabis use, particularly early-onset use and use of other illicit drugs, psychosis and depression, as well as suicide, albeit via differing mechanisms. For other illicit drugs, while there is strong evidence for shared genetic influences, residual association that is attributable to causal or person-specific environmental factors cannot be ruled out. For depression, common genetic influences are solely responsible for the association with cannabis use but for suicidal attempt, evidence for person-specific factors persists. Finally, even though rates of cannabis use are inordinately high in those with psychotic disorders, there is no evidence of shared genetic etiologies underlying this comorbidity. Instead, there is limited evidence that adolescent cannabis use might moderate the extent to which diathesis influences psychosis. Overlapping genetic influences underlie the association between early-onset cannabis use and other illicit drug use as well as depression and suicide. For psychosis, mechanisms other than shared genetic influences might be at play. © 2014 Society for the Study of Addiction.

  18. Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues.

    Directory of Open Access Journals (Sweden)

    Ethan Budd Russo


    Full Text Available This overview covers a wide range of cannabis topics, initially examining issue in dispensaries and self-administration, plus regulatory requirement for production of cannabis-based medicines, particularly the Food and Drug Administration Botanical Guidance. The remainder pertains to various cannabis controversies that certainly require closer examination if the scientific, consumer and governmental stakeholders are ever to reach consensus on safety issues, specifically: whether botanical cannabis displays herbal synergy of its components, pharmacokinetics of cannabis and dose titration, whether cannabis medicines produce cyclo-oxygenase inhibition, cannabis-drug interactions and cytochrome P450 issues, whether cannabis randomized clinical trials are properly blinded, combatting the placebo effect in those trials via new approaches, the drug abuse liability of cannabis-based medicines and their regulatory scheduling, their effects on cognitive function and psychiatric sequelae, immunological effects, cannabis and driving safety, youth usage, issues related to cannabis smoking and vaporization, cannabis concentrates and vape-pens, and laboratory analysis for contamination with bacteria and heavy metals. Finally, the issue of pesticide usage on cannabis crops is addressed. New and disturbing data on pesticide residues in legal cannabis products in Washington State are presented with the observation of an 84.6% contamination rate including potentially neurotoxic and carcinogenic agents. With ongoing developments in legalization of cannabis in medical and recreational settings, numerous scientific, safety and public health issues remain.

  19. LNT--an apparent rather than a real controversy? (United States)

    Charles, M W


    Can the carcinogenic risks of radiation that are observed at high doses be extrapolated to low doses? This question has been debated through the whole professional life of the author--now nearing four decades. In its extreme form the question relates to a particular hypothesis (LNT) used widely by the international community for radiological protection applications. The linear no-threshold (LNT) hypothesis propounds that the extrapolation is linear and that it extends down to zero dose. The debate on the validity of LNT has increased dramatically in recent years. This is in no small part due to concern that exaggerated risks at low doses leads to undue amounts of societal resources being used to reduce man-made human exposure and because of the related growing public aversion to diagnostic and therapeutic medical exposures. The debate appears to be entering a new phase. There is a growing realisation of the limitations of fundamental data and the scientific approach to address this question at low doses. There also appears to be an increasing awareness that the assumptions necessary for a workable and acceptable system of radiological protection at low doses must necessarily be based on considerable pragmatism. Recent developments are reviewed and a historical perspective is given on the general nature of controversies in radiation protection over the years. All the protagonists in the debate will at the end of the day probably be able to claim that they were right!

  20. The controversy of sports technology: a systematic review. (United States)

    Dyer, Bryce


    Changes or introductions of technology or equipment can affect how a sport is played or influence its performances. This article conducted a systematic review of peer-reviewed literature to identify any case studies of controversial events surrounding the implementation or use of sports technology. 56 articles were identified that highlighted 31 different case studies found over a three decade time period. Thematic analysis revealed six distinctive themes when reviewing the articles. Whilst the sport of golf had the highest number of case studies, it was found that a significant level of attention had been recorded in the cases of Oscar Pistorius use of prosthetic legs in athletics and the use of full length swimsuits in swimming. The trend surrounding the number of articles was shown to be initially intermittent but saw a peak period from 2008 to 2010. However, the frequency of such articles since this peak has been more consistent. It is proposed that long periods of time without intervention or resolution by a governing body often increases the peer-reviewed attention paid to such cases in examples such as those identified in this systematic review.

  1. Ethical controversies in organ donation after circulatory death. (United States)


    The persistent mismatch between the supply of and need for transplantable organs has led to efforts to increase the supply, including controlled donation after circulatory death (DCD). Controlled DCD involves organ recovery after the planned withdrawal of life-sustaining treatment and the declaration of death according to the cardiorespiratory criteria. Two central ethical issues in DCD are when organ recovery can begin and how to manage conflicts of interests. The "dead donor rule" should be maintained, and donors in cases of DCD should only be declared dead after the permanent cessation of circulatory function. Permanence is generally established by a 2- to 5-minute waiting period. Given ongoing controversy over whether the cessation must also be irreversible, physicians should not be required to participate in DCD. Because the preparation for organ recovery in DCD begins before the declaration of death, there are potential conflicts between the donor's and recipient's interests. These conflicts can be managed in a variety of ways, including informed consent and separating the various participants' roles. For example, informed consent should be sought for premortem interventions to improve organ viability, and organ procurement organization personnel and members of the transplant team should not be involved in the discontinuation of life-sustaining treatment or the declaration of death. It is also important to emphasize that potential donors in cases of DCD should receive integrated interdisciplinary palliative care, including sedation and analgesia.

  2. Intestinal Neuronal Dysplasia Type B in Adults: A Controversial Entity

    Directory of Open Access Journals (Sweden)

    Vasillis Vougas


    Full Text Available Intestinal neuronal dysplasia (IND is a well-defined entity which raises controversy among authors, described as a congenital malformation of gastrointestinal innervation and caused by dysplastic embryonal development of the enteric nervous system. It is potentially associated with mild and chronic gastrointestinal motility disturbances. IND is rarely reported in adults and especially elderly patients. The present study reports on the case of a 71-year-old man suffering from longstanding idiopathic constipation and who was misdiagnosed for more than 60 years, despite several hospital admissions and a sigmoidectomy in the meantime. On the last admission, the patient presented with megacolon, abdominal pain and X-ray finding of bowel obstruction. Due to massive large bowel dilatation, an exploratory laparotomy failed to reveal any obvious mechanical cause, and a subtotal colectomy and Hartmann's procedure was performed. Bowel continuity was performed 3 months later. Analysis of full-thickness biopsies revealed enlarged myenteric and submucosal neurons as well as an increased number of giant cells and increased acetylcholinesterase activity in the mucosa. The diagnosis of IND was established. The main diagnostic criteria, the underlining pathophysiology and the recommended therapeutic approach of this rare entity are extensively reviewed.

  3. Emerging from the rib: resolving the turtle controversies. (United States)

    Rice, Ritva; Riccio, Paul; Gilbert, Scott F; Cebra-Thomas, Judith


    Two of the major controversies in the present study of turtle shell development involve the mechanism by which the carapacial ridge initiates shell formation and the mechanism by which each rib forms the costal bones adjacent to it. This paper claims that both sides of each debate might be correct-but within the species examined. Mechanism is more properly "mechanisms," and there is more than one single way to initiate carapace formation and to form the costal bones. In the initiation of the shell, the rib precursors may be kept dorsal by either "axial displacement" (in the hard-shell turtles) or "axial arrest" (in the soft-shell turtle Pelodiscus), or by a combination of these. The former process would deflect the rib into the dorsal dermis and allow it to continue its growth there, while the latter process would truncate rib growth. In both instances, though, the result is to keep the ribs from extending into the ventral body wall. Our recent work has shown that the properties of the carapacial ridge, a key evolutionary innovation of turtles, differ greatly between these two groups. Similarly, the mechanism of costal bone formation may differ between soft-shell and hard-shell turtles, in that the hard-shell species may have both periosteal flattening as well as dermal bone induction, while the soft-shelled turtles may have only the first of these processes. © 2015 Wiley Periodicals, Inc.

  4. Trust, patents and public perceptions: the governance of controversial biotechnology research. (United States)

    Caulfield, Timothy; Einsiedel, Edna; Merz, Jon F; Nicol, Dianne


    The sustainability of many research endeavors, particularly in controversial areas, requires an understanding of public concerns. As such, governance strategies should be developed to sustain public trust.

  5. Rates of induced abortion in Denmark according to age, previous births and previous abortions

    Directory of Open Access Journals (Sweden)

    Marie-Louise H. Hansen


    Full Text Available Background: Whereas the effects of various socio-demographic determinants on a woman's risk of having an abortion are relatively well-documented, less attention has been given to the effect of previous abortions and births. Objective: To study the effect of previous abortions and births on Danish women's risk of an abortion, in addition to a number of demographic and personal characteristics. Data and methods: From the Fertility of Women and Couples Dataset we obtained data on the number of live births and induced abortions by year (1981-2001, age (16-39, county of residence and marital status. Logistic regression analysis was used to estimate the influence of the explanatory variables on the probability of having an abortion in a relevant year. Main findings and conclusion: A woman's risk of having an abortion increases with the number of previous births and previous abortions. Some interactions were was found in the way a woman's risk of abortion varies with calendar year, age and parity. The risk of an abortion for women with no children decreases while the risk of an abortion for women with children increases over time. Furthermore, the risk of an abortion decreases with age, but relatively more so for women with children compared to childless women. Trends for teenagers are discussed in a separate section.

  6. [Neuroethics and bioethics--implications of Balkanization controversy]. (United States)

    Kagawa, Chiaki


    There have been considerable disputes the positioning of neuroethics as a new field since its emergence in 2002. It is the novelty of the neuroethical issues and the necessity for updated moral approaches to them that leading exponents of neuroethics have emphasized; advances in neurosciences have created an entirely new field of moral inquiries that the conventional bioethics had never noticed. Futher, as neuroethics embraces the subdivision of ethics in neuroscience, it should take precedence over bioethics, which depends on the fundamental moral concepts without questioning their bases. Many bioethicists have squarely opposed these insistences and thereby detected the claim of neuroethics exceptionalism: the asserted newness of issues comes mainly from the ignorance of exponents of this new field regarding accumulated bioethical inquiries, so that the overlapping concerns between bioethics and neuroethics are passed on to the future by them. Moreover, bioethicists point out that the recent tendency of Balkanization in the field of bioethics could endanger the integrity of moral investigations. Subfields of bioethics, such as geneethics, neuroethics, nanoethics and so on, originate consecutively, entail wastage of valuable time and money, and increase the risk of fragmentizing moral considerations in an inconsistent way. By reviewing this controversy between neuroethics and bioethics, I argue that the relevant scientific investigations and technologies, which have appeared to promote the proliferation of bioethical sub-disciplines to date, are beginning to converge into 1 complex that demands not the division into subspecialities but the novel integration of bioethical inquiries: it is time to attempt the unification of bioethical applied ethics for moral considerations regarding nano-bio-info-cogno convergent technologies.

  7. Management of ß-thalassemia – Consensus and controversies!

    Directory of Open Access Journals (Sweden)

    Mamta V. Manglani


    Full Text Available The mainstay of treatment of ß-Thalassemia major includes life-long regular packed red cell transfusions and iron chelation. With advances in understanding the molecular biology and its implications in the patients, newer modalities are now being explored to offer a better quality of life to transfusion dependent thalassemic patients. Improved safety of transfusions, newer chelator drugs and combination of chelators have improved outcomes in these patients. Amlodipine along with chelators may be a future option for preventing cardiac iron overload related complications. Drugs which improve HbF levels and thus ameliorate anemia such as hydroxyurea, butyrates azacytidine etc. have also been explored with little relief to transfusion dependent patients. HSCT, which is the only curative treatment available at present, has its own limitations as sibling donors may not be available to many. However, there has been extensive work done on improving outcomes with MUD and Haplo-identical HSCT in the recent times. Gene therapy using lentiviral vectors is also offering great hope to these children. Induced Pluripotent Stem Cells (iPSC is a promising advance in the treatment of thalassemia. Several newer molecules targeting different pathophysiologic aspects are being explored and have met with good success. These include luspatercept, sotatercept, macrophage inhibition, JAK2 inhibition using ruxolitinib etc. Controversies regarding use of wheat grass and ESAs are relatively less worrisome. But use of thalidomide should be done with great caution. Despite its success reported in anecdotal reports, in the absence of adequate data with larger trials, its role in routine management of thalassemia syndromes remains to be ascertained.

  8. 25 Years of Self-organized Criticality: Concepts and Controversies (United States)

    Watkins, Nicholas W.; Pruessner, Gunnar; Chapman, Sandra C.; Crosby, Norma B.; Jensen, Henrik J.


    Introduced by the late Per Bak and his colleagues, self-organized criticality (SOC) has been one of the most stimulating concepts to come out of statistical mechanics and condensed matter theory in the last few decades, and has played a significant role in the development of complexity science. SOC, and more generally fractals and power laws, have attracted much comment, ranging from the very positive to the polemical. The other papers (Aschwanden et al. in Space Sci. Rev., 2014, this issue; McAteer et al. in Space Sci. Rev., 2015, this issue; Sharma et al. in Space Sci. Rev. 2015, in preparation) in this special issue showcase the considerable body of observations in solar, magnetospheric and fusion plasma inspired by the SOC idea, and expose the fertile role the new paradigm has played in approaches to modeling and understanding multiscale plasma instabilities. This very broad impact, and the necessary process of adapting a scientific hypothesis to the conditions of a given physical system, has meant that SOC as studied in these fields has sometimes differed significantly from the definition originally given by its creators. In Bak's own field of theoretical physics there are significant observational and theoretical open questions, even 25 years on (Pruessner 2012). One aim of the present review is to address the dichotomy between the great reception SOC has received in some areas, and its shortcomings, as they became manifest in the controversies it triggered. Our article tries to clear up what we think are misunderstandings of SOC in fields more remote from its origins in statistical mechanics, condensed matter and dynamical systems by revisiting Bak, Tang and Wiesenfeld's original papers.

  9. Controversy in the management of optic nerve glioma

    International Nuclear Information System (INIS)

    Weiss, L.; Sagerman, R.H.; King, G.A.; Chung, C.T.; Dubowy, R.L.


    The records of 16 patients with optic nerve glioma treated between 1961 and 1984 were reviewed. All patients except two had extension of tumor beyond the chiasm to the hypothalamus, adjacent brain and/or along the posterior optic tract. Eleven of 16 cases were biopsy-proven, two patients had craniotomy and visual inspection but no biopsy was performed, and in two cases the biopsy was not diagnostic. Fourteen patients received radiation therapy, usually consisting of 50 Gy in 5 weeks (range 40-56 Gy), one patient was treated surgically and one with chemotherapy. With a follow-up of 1 to 20 years, 7 of the 14 patients irradiated are alive, three patients are dead of disease at 3, 6 and 9 years post-treatment, three were lost to follow-up at 1, 8, and 8 years, and one is dead of intercurrent disease at 5.5 years. Overall vision was improved in five patients and stable in seven following treatment. In two patients, vision could not be evaluated because of young age at presentation. Four patients had recurrences. One was retreated with 30 Gy in 3 weeks and shows no evidence of disease at 20 years. The three other patients died of their disease. There is controversy over the best treatment for these patients. Based on these results and a review of the literature, the authors recommendation is to irradiate tumors with extension beyond the chiasm at the time of presentation rather than waiting for increasing symptoms because function that is lost may not always be recovered. Chemotherapy needs to be further investigated but holds promise, especially for the younger children

  10. Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004

    Directory of Open Access Journals (Sweden)

    N Dabiri


    Full Text Available ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent of the subjects and 19 people (47.5 percent of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.

  11. Kidnapping Detection and Recognition in Previous Unknown Environment

    Directory of Open Access Journals (Sweden)

    Yang Tian


    Full Text Available An unaware event referred to as kidnapping makes the estimation result of localization incorrect. In a previous unknown environment, incorrect localization result causes incorrect mapping result in Simultaneous Localization and Mapping (SLAM by kidnapping. In this situation, the explored area and unexplored area are divided to make the kidnapping recovery difficult. To provide sufficient information on kidnapping, a framework to judge whether kidnapping has occurred and to identify the type of kidnapping with filter-based SLAM is proposed. The framework is called double kidnapping detection and recognition (DKDR by performing two checks before and after the “update” process with different metrics in real time. To explain one of the principles of DKDR, we describe a property of filter-based SLAM that corrects the mapping result of the environment using the current observations after the “update” process. Two classical filter-based SLAM algorithms, Extend Kalman Filter (EKF SLAM and Particle Filter (PF SLAM, are modified to show that DKDR can be simply and widely applied in existing filter-based SLAM algorithms. Furthermore, a technique to determine the adapted thresholds of metrics in real time without previous data is presented. Both simulated and experimental results demonstrate the validity and accuracy of the proposed method.

  12. Controversy and consensus on a clinical pharmacist in primary care in the Netherlands

    NARCIS (Netherlands)

    Hazen, A.C.M.; van der Wal, Aletta W.; Sloeserwij, Vivianne M.; Zwart, Dorien L M; de Gier, Johan J; De Wit, Niek J.; Leendertse, A.J.; Bouvy, M.L.; De Bont, Antoinette A.


    Background Controversy about the introduction of a non-dispensing pharmacist in primary care practice hampers implementation. Objective The aim of this study is to systematically map the debate on this new role for pharmacists amongst all stakeholders to uncover and understand the controversy and

  13. Teacher College Students' Views of Controversial Environmental Issues: Ambivalence and Readiness to Adopt a Stance (United States)

    Weinberger, Yehudith; Dreyfus, Amos


    One of the most important goals of discussing controversial issues in the classroom is to educate students to possess an inclination towards reason, open mindedness and fairness. However, research tends to show that teachers are not adequately trained to lead fruitful discussions about controversial issues and do not possess the necessary skills…

  14. Emergence of controversy in technology transitions: Green revolution and Bt cotton in India

    NARCIS (Netherlands)

    Ramani, S.V.; Thutupalli, A.


    Technology transitions following radical technological breakthroughs are often marked by controversies and the transitions to Green Revolution (GR) and Genetically Modified (GM) seeds in India were no exceptions to this rule. Controversies can trigger social dilemmas, but in economics we do not yet

  15. What Can We Learn from Taiwanese Teachers about Teaching Controversial Public Issues? (United States)

    Hung, Yu-Han


    This study explores how history teachers in Taiwan make curricular decisions while engaging controversial public issues. The main political controversies discussed in Taiwanese society center on the relationship between Taiwan and the People's Republic of China. This study documents how four social studies teachers formulate their curricular…

  16. The Use and Abuse of "Universal Values" in the Danish Cartoon Controversy

    DEFF Research Database (Denmark)

    Rostbøll, Christian Fogh

    During the Danish cartoon controversy in 2005-2006 appeals to universal liberal values were often made in ways that marginalized Muslims. An analysis of the controversy shows that referring to "universal values" can be exclusionary when dominant actors fail to distinguish their own culture's embo...

  17. The Problem of Catholic School Teachers Deferring to the Home on Controversial Religious Issues (United States)

    McDonough, Graham P.


    This paper observes that an ironic tension occurs in the discussion of controversial issues in some Catholic schools. One technique that teachers use in response to student disagreement with the official Church view on a controversial issue like contraception, homosexuality, or female ordination is to present Church teaching but then suggest that…

  18. "Topoi" of Religious Controversy in the American Catholic Debate over Vernacular Reform. (United States)

    Wiethoff, William E.


    Proposes that arguments used popularly in religious controversies are historically stable and that the rhetorical critic's attention to topics or sources of reference ("topoi") for argumentation enhances the analysis of such controversies. Examines the Catholic debate over vernacular reform and emphasizes the relatively narrow range of "topoi"…

  19. Scientific Experts and the Controversy about Teaching Creation/Evolution in the UK Press (United States)

    Allgaier, Joachim


    The issue whether creationist accounts of the origins of life should be taught in science education alongside or even instead Darwin's theory of evolution is controversial in many countries. In 2002 there was a controversy around teaching creationism in science classes at a secondary school in England. The research presented in this paper uses…

  20. The Effects of Controversy, Concurrence Seeking, and Individualistic Learning on Achievement and Attitude Change. (United States)

    Johnson, Roger; And Others


    Compared effects of cooperative learning activities (with and without structured controversy) and individualistic learning activities on the achievement and attitudes of fifth graders (N=84) toward wolves. Results show that cooperative-controversy resulted in the highest achievement, greatest motivation to learn about wolves, and more positive…

  1. The Case of the Danish Cartoons Controversy: The Paradox of Civility

    DEFF Research Database (Denmark)

    Lægaard, Sune


    to understand how some views and interventions in the controversy were displaced or misrepresented, which gave defenders of Jyllands-Posten a rhetorical advantage that allowed them to dominate the controversy, at least in Denmark. But the very framing of the debate in terms of civility also leads to a problem...

  2. Sjögren's syndrome. Controversies and progress. (United States)

    Fox, R I


    Diagnostic criteria for Sjögren's syndrome (SS) are required by both physicians and patients to (1) provide a rational basis for their symptoms, assess their prognosis, and guide therapy; (2) identify a group of patients who are most likely to share a common etiopathogenesis, in order to identify those genetic and environmental factors that are crucial in pathogenesis; (3) fill out the myriad medical insurance forms that require a diagnosis code; and (4) serve as a "shorthand" code that alerts specialists in different fields (oral medicine, ophthalmology, and a variety of specialists in internal medicine) to search for particular clinical problems found in the SS patient. The key question in this article is whether the term "Sjögren's syndrome" should apply to a rather restricted group of individuals (those with an autoimmune basis for exocrinopathy) or to a rather large group of individuals who share a similar symptom complex of dry eyes and mouth. Primary SS, as defined by San Diego criteria, is a systemic autoimmune disease that is characterized by keratoconjunctivitis sicca and xerostomia resulting from lymphocytic infiltrates of the lacrimal and salivary glands. The criteria for the diagnosis of SS continues to be controversial, leading to confusion in the clinical and research literature. It is important to distinguish SS (an idiopathic autoimmune process) from other processes including hepatitis C infection, retroviral infection, lymphoma, autonomic neuropathy, depression, primary fibromyalgia, and drug side effects that can result in sicca symptoms. Recent studies on pathogenesis of SS in human and animal models have examined the clonality of the T-cell infiltrates, the production of cytokines by lymphocytes and glandular epithelial cells, neuroendocrine and hormonal factors that affect glandular secretion, and the fine structure of antigens recognized by T cells and B cells. Studies in SS have allowed comparison of lymphocytes in blood and in the

  3. The Neglected Patent Controversies in the Twenty First Century

    Directory of Open Access Journals (Sweden)

    Birgitte Andersen


    Full Text Available Na virada do século, assistimos a um reforço do sistema de patentes. No entanto, os gestores de políticas deixam sistematicamente de lado as controvérsias sobre patentes. Este artigo examina criticamente as complexas relações entre, por um lado, as razões para os direitos de patente e, por outro lado, seus efeitos sociais e econômicos. Só quando entendermos essa relação, seremos capazes de projetar regimes adequados de Direitos de Propriedade Intelectual (DPI para o novo paradigma tecnoeconômico de microeletrônica baseada em conhecimento e invenções de amplo alcance implementadas por computador. O foco se concentra nas razões morais, nas razões de incentivo econômico, e nas razões de aumento da concorrência e "proteção do talento empresarial no mercado", e nas razões econômicas para organizar ciência, tecnologia e criatividade. Afirma-se aqui que os sistemas de patentes não são neutros, eles estabelecem as regras do jogo em que indivíduos e organizações são os jogadores.At the turn of the century we have seen a tightening of the patent system. However, policy makers systematically neglect the patent controversies. This article critically reviews the complex relationships between the rationales for patent rights on the one hand, and the social and economic effects of such on the other hand. Only when we understand this relationship, will we be able to design appropriate Intellectual Property Right (IPR regimes for the new technoeconomic paradigm of knowledge-based micro-electronics and computer implemented pervasive inventions. Focus is on moral rationales, economic incentive rationales, increased competition and "market protection of entrepreneurial talent" rationales, and the economic rationales for organizing science, technology and creativity. It is argued that patent systems are not neutral, but set the rules of the game in which individuals and organizations are the players.

  4. Measles vaccination and inflammatory bowel disease: controversy laid to rest? (United States)

    Davis, R L; Bohlke, K


    infection and IBD have been contentious. While some investigators have claimed to find persistent measles infection among patients with IBD, others, using highly sensitive polymerase chain reaction techniques, have not been able to replicate the findings. Recent controversy has centred on whether there is any evidence for molecular mimicry in the pathogenesis of IBD. In summary, available evidence does not support an association between measles-containing vaccines and risk of IBD, nor between measles infection and IBD. While further research is necessary into the causal factors underlying Crohn's disease and ulcerative colitis, continued public education efforts are needed to reassure the public about vaccine safety and to prevent declines in vaccine coverage.

  5. The heritage and museums field: A controversial cultural space

    Directory of Open Access Journals (Sweden)

    Arrieta Urtizberea, Iñaki


    Full Text Available The processes of acceptance as heritage and musealisation do not respond to history or aesthetics-related criteria, but rather to identity-related criteria. They do not concern scientists, specialists and policy-makers alone, but also social groups. The choice of cultural assets is not an objective consequence of their formal characteristics. It is the result of the selection made by social agents so as to represent a group identity. But no social group is homogeneous; on the contrary they are diverse and complex so the identity references, and therefore the cultural assets, do not have to be univocal. Beyond the aseptic discourses, many of these processes are controversial. Differences regarding the identity references and the uses to be made of cultural assets lead to the field of heritage and museums being spaces where interests and values clash. This article presents and analyses the conflicts that arose in the Basque municipality of Legazpi when the process of musealisation and acceptance of iron production as heritage first started.

    Los procesos de patrimonialización y musealización de la cultura no responden a criterios históricos o estéticos, sino identitarios. No atañen a científicos, especialistas y políticos solamente, sino a colectivos sociales. La elección de unos bienes culturales no es una consecuencia objetiva de sus características formales, es el resultado de la selección llevada a cabo por agentes sociales con el fin de representar una identidad grupal. Pero ningún colectivo social es uniforme, sino, al contrario, es diverso y complejo, de tal modo que los referentes identitarios y, consecuentemente, los bienes culturales no tienen por qué ser unívocos. Más allá de los discursos asépticos, muchos de esos procesos se presentan conflictivos. Diferencias acerca de los referentes identitarios y de los usos que se les quieren dar a los bienes culturales acarrean que el campo patrimonial y museístico sea un

  6. artery splenic entIty Aneurysm of the controversial

    African Journals Online (AJOL)


    Jan 8, 1983 ... methods of diagnosis of splenic artery aneur~sms have been exrenslvely revIewed III prevIOus pubhcations, 9 this commu- nication reports the successful elective resection of a non- ruptured, calcified splenic artery aneurysm. Case report. A 60-year-old White woman was admitted to Tygerberg Hospi-.

  7. Health effects of low level exposure to ionizing radiation: origin and development of a controversy

    International Nuclear Information System (INIS)

    Masse, Roland


    Health hazard assessment related to doses of ionizing radiation lower than 100-200 mSv is a matter of controversy, and more acutely when choosing transition towards a new energetic paradigm. Neither epidemiological nor experimental data can be used to determine the shape of the dose-effect relationship from 0 to 100 mSv. Recently, however, long term follow-up of children and young adults exposed to CT scans evidenced that doses of 50 to 60 mGy delivered at high dose-rate were associated to a significant increase of leukemias and cancers, including brain cancer. On the basis of the available data, this article leaves some questions about the plausibility of the linear no threshold hypothesis (LNT) used by radiological protection bodies to control overexposure of the members of public and workers. It concludes that although the plausibility of LNT is fairly weak, using LNT helps to situate the order of magnitude of health risks associated with the development of nuclear power plants and to compare them with those resulting from burning fossil fuels and biomass; the results show that sparing human lives can only be achieved with nuclear for the same quantity of energy produced. (author)

  8. How the Prohormone Theory Solved Two Important Controversies in Hormonal and Neural Peptide Biosynthesis

    Directory of Open Access Journals (Sweden)

    Michel eChretien


    Full Text Available This Prohormone Theory was simultaneously proposed in 1967 by two independent groups using two different approaches and two experimental models. Donald Steiner, in elegant pulse-chase experiments, proposed the existence of proinsulin when he observed that a human insulinoma was producing higher MW forms of immunoreactive insulin, subsequently transformed into insulin-like material (Steiner et al., 1967. Simultaneously and independently, Michel Chrétien, based on amino acid sequence homologies between three pituitary peptides, -lipotropic hormone (β-LPH, -LPH and -melanocycte-stimulating hormone (β-MSH, concluded that active peptide hormones are derived from endoproteolytic cleavages of inactive precursors, apparently at pairs of basic amino acids (Chrétien and Li, 1967. One year later, Donald Chance confirmed that the cleavage sites in proinsulin were also made of paired basic amino acids (Chance et al., 1968. This novel paradigm solved two major controversies on the biosynthesis of both insulin and neuropeptides. This short review describes how.

  9. Resolving scientific controversy over smelter risks and neurodegenerative effects of metals

    Directory of Open Access Journals (Sweden)

    Rebecca L. Thomas


    Full Text Available Although it is well known that metals pollution can cause neurotoxic effects, scientists are currently divided about the neurodegeneration hypothesis. That is, some scientists accept, while others fail to accept, the hypothesis that metals/metalloids, at exposure levels below those capable of causing neurotoxicity, can cause neurodegeneration—progressive or worsening neurological disease. Partly because of controversy over the neurodegeneration hypothesis, the US and other governments do not require cleanup of smelter-site metals, to the level (that many scientists say is necessary to prevent site-caused neurodegenerative disease. The purpose of this review article is to help clarify and resolve conflict over the neurodegeneration hypothesis. This analysis (1 surveys the global problem of smelter-related metals pollution; (2 quickly gives an overview of metals pollution at one of the worst US Superfund or hazardous-waste sites, a former smelter in DePue, Illinois; (3 outlines the debate over the neurodegeneration hypothesis; and (4 assesses the current science on both sides of the neurodegeneration hypothesis by means of three classic methods of causal assessment: the mechanism, unification-coherence, and experimental-counterfactual methods. Using these classic methods, the authors (5 show that available scientific evidence argues for accepting the neurodegeneration hypothesis. This finding is significant because it suggests that much current science about smelters and metals’ risks may be incomplete or flawed. It also shows that, as a result, there may be sound scientific reasons for strengthening environmental-metals standards.

  10. Sleepless vigilance: "Stonewall" Jackson and the duty hours controversy. (United States)

    Mackowiak, Philip A; Billings, Frederic T; Wasserman, Steven S


    Confederate general "Stonewall" Jackson has been called "one of the greatest military geniuses the world ever saw." However, on critical review of his command decisions during the course of 12 of the 20 battles he fought during the American Civil War, historians have rated his performance as poor. In this investigation, the authors examined the effect of sleep deprivation on Jackson's battle decisions in light of experimental data driving current calls for limiting the duty hours of physicians.

  11. Nosema ceranae (Microsporidia), a controversial 21st century honey bee pathogen. (United States)

    Higes, Mariano; Meana, Aránzazu; Bartolomé, Carolina; Botías, Cristina; Martín-Hernández, Raquel


    The worldwide beekeeping sector has been facing a grave threat, with losses up to 100-1000 times greater than those previously reported. Despite the scale of this honey bee mortality, the causes underlying this phenomenon remain unclear, yet they are thought to be multifactorial processes. Nosema ceranae, a microsporidium recently detected in the European bee all over the world, has been implicated in the global phenomenon of colony loss, although its role remains controversial. A review of the current knowledge about this pathogen is presented focussing on discussion related with divergent results, trying to analyse the differences specially based on different methodologies applied and divisive aspects on pathology while considering a biological or veterinarian point of view. For authors, the disease produced by N. ceranae infection cannot be considered a regional problem but rather a global one, as indicated by the wide prevalence of this parasite in multiple hosts. Not only does this type of nosemosis causes a clear pathology on honeybees at both the individual and colony levels, but it also has significant effects on the production of honeybee products. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  12. Controversies and Advances in Gestational Diabetes—An Update in the Era of Continuous Glucose Monitoring

    Directory of Open Access Journals (Sweden)

    Marina P. Carreiro


    Full Text Available Diabetes in pregnancy, both preexisting type 1 or type 2 and gestational diabetes, is a highly prevalent condition, which has a great impact on maternal and fetal health, with short and long-term implications. Gestational Diabetes Mellitus (GDM is a condition triggered by metabolic adaptation, which occurs during the second half of pregnancy. There is still a lot of controversy about GDM, from classification and diagnosis to treatment. Recently, there have been some advances in the field as well as recommendations from international societies, such as how to distinguish previous diabetes, even if first recognized during pregnancy, and newer diagnostic criteria, based on pregnancy outcomes, instead of maternal risk of future diabetes. These new recommendations will lead to a higher prevalence of GDM, and important issues are yet to be resolved, such as the cost-utility of this increase in diagnoses as well as the determinants for poor outcomes. The aim of this review is to discuss the advances in diagnosis and classification of GDM, as well as their implications in the field, the issue of hyperglycemia in early pregnancy and the role of hemoglobin A1c (HbA1c during pregnancy. We have looked into the determinants of the poor outcomes predicted by the diagnosis by way of oral glucose tolerance tests, highlighting the relevance of continuous glucose monitoring tools, as well as other possible pathogenetic factors related to poor pregnancy outcomes.

  13. Journal of Controversies in Biomedical Research - the Need of the Hour

    Directory of Open Access Journals (Sweden)

    Christudas Morais


    Full Text Available Approximately 75-89% of the peer–reviewed published literature are thought to be non-reproducible. A need exists to better address the problem of irreproducibility of research data so that contradictory, null and negative findings can be disclosed in an unbiased, non-judgemental, yet scientifically plausible manner. Journal of Controversies in Biomedical Research (JCBMR; is an attempt to address the ‘reproducibility crisis’ in biomedical research. JCBMR is an online-only open access journal that will publish basic science or clinical research articles that meet any of the following criteria: a original articles that demonstrate biologically plausible negative, neutral or contentious findings; b original articles that challenge previously published results in peer-reviewed journals; c original articles that show effects of compounds on disease models (either in vitro or in vivo are contradictory to the expected outcome; d review articles that critically evaluate and challenge established norms and offer possible solutions to the problem; e any manuscript that will assist the scientific community to re-think and re–evaluate the established norm.

  14. The One-Trial Learning Controversy and Its Aftermath: Remembering Rock (1957) (United States)

    Roediger, Henry L.; Arnold, Kathleen M.


    In 1957 Irvin Rock published an article in the American Journal of Psychology igniting a controversy that dominated the field of verbal learning for the next 8 years before mostly burning out. Rock published 2 paired-associate learning experiments in which he compared performance of a control group that learned a constant list of pairs to the criterion of one perfect trial with an experimental group in which forgotten pairs on each trial were dropped and replaced on the next trial with new pairs. That is, on each trial for experimental subjects, pairs that were correctly recalled were maintained in the next trial, whereas pairs that were not recalled were dropped and replaced randomly with new pairs from a large pool. Surprisingly, Rock found that the 2 groups took the same number of trials to reach criterion. He concluded that learning occurred not with a gradual, incremental increase in strength of memory traces but rather in an all-or-none fashion. Rock’s conclusions rocked the world of verbal learning, because all theories followed a gradualist assumption. However, Estes (1960) published research that led him to the same conclusion shortly thereafter. We recount these developments and discuss how the verbal learning establishment rose up to smite down these new ideas, with particular ferocity directed at Rock. Echoing G. A. Miller (1963), we conclude with a note of sympathy for Rock’s and Estes’s positions and muse about why their work was so summarily dismissed. The important question they raised—the nature of how associations are learned—remains unanswered. PMID:22774677

  15. The Controversy Of Stabilization Of Advanced Protection In Antecedent Quality


    Marchetti Filho, Gilberto Ferreira; Assumpção, Jenifer Bacon


    The preliminary injunction deals with the immediate concession of the executive effects of the final provision. According to the current CPC, in cases of urgency, the initial request for previous protection may be superficial, dealing only with the situation of urgency, without discussing all the matters at issue. Subsequently, the initial petition may be added, to complete all the matter to be discussed. If the defendant does not demonstrate his nonconformity regarding the approval, its effe...

  16. The quantum challenge. A century of discoveries and controversies

    International Nuclear Information System (INIS)

    Berthon, M.E.


    This book draws the history of modern physics. The reader can follow the evolution of the representation of the real world by scientists all along this century. This history is detailed and we can seize the moment when a theory is driven away by another, we witness the confrontation of ideas, the emergence of new concepts, the fall of dead-end theories. The decisive experimental facts are thoroughly described. At the end of the book we find a dictionary of scientific terms and a series of short biographies about the main scientists who have built modern physics. (A.C.)

  17. The Controversy Of Stabilization Of Advanced Protection In Antecedent Quality

    Directory of Open Access Journals (Sweden)

    Gilberto Ferreira Marchetti Filho


    Full Text Available The preliminary injunction deals with the immediate concession of the executive effects of the final provision. According to the current CPC, in cases of urgency, the initial request for previous protection may be superficial, dealing only with the situation of urgency, without discussing all the matters at issue. Subsequently, the initial petition may be added, to complete all the matter to be discussed. If the defendant does not demonstrate his nonconformity regarding the approval, its effects will be stabilized. After the deadline, it becomes final. There are several problems arising from this legal novelty, which are the object of the present.

  18. Positive Behavioral Interventions and Support as Behavior Analysis in Practice: Why Is This Even Controversial? (United States)

    Jarmolowicz, David P; Tetreault, Allison S


    The inclusion of Positive Behavioral Intervention and Supports as a type of applied behavior analysis has often spurred considerable controversy. This controversy seems related to at least three areas of contention: measurement issues, views on aversive control, and the overall target of treatment. The present paper discusses these three areas in light of Horner and Sugai's target article and the current state of the field of applied behavior analysis. In the end, the authors are left wondering why this is even an ongoing controversy.

  19. Progress and controversies in unraveling the glomerular filtration mechanism. (United States)

    Saritas, Turgay; Kuppe, Christoph; Moeller, Marcus J


    At first sight, the glomerular filter appears like a problem that should be easily solved. The majority of researchers view the filter like an impermeable wall perforated by specialized and size-selective pores (pore model). However, the fact that this model is in conflict with many of the experimental findings suggests that it may not yet be complete. In the more recent electrokinetic model, we have proposed including electrical effects (streaming potentials). The present review investigates how this can provide a relatively simple mechanistic explanation for the great majority of the so far unexplained characteristics of the filter, for example why the filter never clogs. Understanding how the glomerular filter functions is a prerequisite to investigate the pathogenesis of proteinuric glomerular diseases and the link between glomerular proteinuria and cardiovascular disease.

  20. Blindsight: Recent and historical controversies on the blindness of blindsight

    DEFF Research Database (Denmark)

    Overgaard, Morten


    of blindsight is a history of changing experimental paradigms and very few patients. In late 19th century, researchers debatedwhy lesions to primary visual cortex seemingly left some visual abilities intact in animals, while human patients reported to be blind. From the 1970s until today, experiments have......The phenomenon ‘blindsight’ has received much interest from neuroscientists, philosophers, and psychologists during the last decades. Several researchers seem to agree that blindsight might be of great importance in the ambition to find neural correlates of consciousness. However, the history...... attempted to compare measures of conscious and unconscious perception, suggesting a distinction between visual functions and visual experience. However, more recently, newer methods and an interest in introspective reports have cast doubts about the ‘blindness’ of blindsight. A cautious conclusion...

  1. Electronic properties of linear carbon chains: Resolving the controversy (United States)

    Al-Backri, Amaal; Zólyomi, Viktor; Lambert, Colin J.


    Literature values for the energy gap of long one-dimensional carbon chains vary from as little as 0.2 eV to more than 4 eV. To resolve this discrepancy, we use the GW many-body approach to calculate the band gap Eg of an infinite carbon chain. We also compute the energy dependence of the attenuation coefficient β governing the decay with chain length of the electrical conductance of long chains and compare this with recent experimental measurements of the single-molecule conductance of end-capped carbon chains. For long chains, we find Eg = 2.16 eV and an upper bound for β of 0.21 Å-1.

  2. The Twiss-Hanbury Brown controversy : A 40-years perspective

    Energy Technology Data Exchange (ETDEWEB)

    Goodman, P.; Langer, W.S.; Brumby, S.P.


    Some key points in the debate over the visible light {sup i}ntensity interferometer{sup ,} initiated by Hanbury Brown and Twiss`s 1956 observation of a positive correlation between two photomultiplier signals from a split-beam optical source, are re-examined. This was a preliminary to their first measurement of a stellar diameter by this means, made in the same year, in the face of great experimental difficulties and criticism of their method, which produced a value for the angular diameter of {alpha}-Sirius which is not only in agreement with present-day measurements, but which provided one of the first tests of quantum electrodynamical theory, and considerably stimulated its further development. We also examine the role which could still be played by {sup i}ntensity interferometry{sup ,} which would be complementary to the programs currently employing Michelson interferometry, by analogy with present-day high-resolution electron microscopy. (authors).

  3. The Twiss-Hanbury Brown controversy : A 40-years perspective

    International Nuclear Information System (INIS)

    Goodman, P.; Langer, W.S.; Brumby, S.P.


    Some key points in the debate over the visible light i ntensity interferometer , initiated by Hanbury Brown and Twiss's 1956 observation of a positive correlation between two photomultiplier signals from a split-beam optical source, are re-examined. This was a preliminary to their first measurement of a stellar diameter by this means, made in the same year, in the face of great experimental difficulties and criticism of their method, which produced a value for the angular diameter of α-Sirius which is not only in agreement with present-day measurements, but which provided one of the first tests of quantum electrodynamical theory, and considerably stimulated its further development. We also examine the role which could still be played by i ntensity interferometry , which would be complementary to the programs currently employing Michelson interferometry, by analogy with present-day high-resolution electron microscopy. (authors)

  4. Electronic properties of linear carbon chains: Resolving the controversy

    International Nuclear Information System (INIS)

    Al-Backri, Amaal; Zólyomi, Viktor; Lambert, Colin J.


    Literature values for the energy gap of long one-dimensional carbon chains vary from as little as 0.2 eV to more than 4 eV. To resolve this discrepancy, we use the GW many-body approach to calculate the band gap E g of an infinite carbon chain. We also compute the energy dependence of the attenuation coefficient β governing the decay with chain length of the electrical conductance of long chains and compare this with recent experimental measurements of the single-molecule conductance of end-capped carbon chains. For long chains, we find E g = 2.16 eV and an upper bound for β of 0.21 Å −1

  5. Multispecies Coevolution Particle Swarm Optimization Based on Previous Search History

    Directory of Open Access Journals (Sweden)

    Danping Wang


    Full Text Available A hybrid coevolution particle swarm optimization algorithm with dynamic multispecies strategy based on K-means clustering and nonrevisit strategy based on Binary Space Partitioning fitness tree (called MCPSO-PSH is proposed. Previous search history memorized into the Binary Space Partitioning fitness tree can effectively restrain the individuals’ revisit phenomenon. The whole population is partitioned into several subspecies and cooperative coevolution is realized by an information communication mechanism between subspecies, which can enhance the global search ability of particles and avoid premature convergence to local optimum. To demonstrate the power of the method, comparisons between the proposed algorithm and state-of-the-art algorithms are grouped into two categories: 10 basic benchmark functions (10-dimensional and 30-dimensional, 10 CEC2005 benchmark functions (30-dimensional, and a real-world problem (multilevel image segmentation problems. Experimental results show that MCPSO-PSH displays a competitive performance compared to the other swarm-based or evolutionary algorithms in terms of solution accuracy and statistical tests.

  6. Media framing of techno-environmental controversies: A case study of the 'Paper-Mills Conflict’ between Argentina and Uruguay

    Directory of Open Access Journals (Sweden)

    Carina Cortassa


    Full Text Available This article embraces the framing studies’ perspective to approach the media construction of the current techno-environmental controversy between Argentina and Uruguay, due to the location of an industrial plant to produce cellulose paper in the uruguayan community of Fray Bentos. The analysis is centered on the respective coverages developed by two argentinean print media –daily newspapers Clarín and Página 12– during three key stages in the evolution of the conflict. A sample composed of 1004 articles was examined using a protocol based in previously tested instruments, which was elaborated to quantify the incidence of five frames established a priori: a environmental; b scientific-technological; c political-juridical; d social; e of economic causes & consequences. The evidence collected indicates that the analyzed media represented the controversy mostly in political-juridical terms and drastically overshadowed its environmental origins and the discrepancies of scientific and technical nature involved in its roots and development. The article discusses some results of the research experience, as well as the limitations and posibilites to extend the framing typology rehearsed here to other media coverages of similar situations, independently of its specific object.

  7. Osteoporotic pertrochanteric hip fractures: management and current controversies. (United States)

    Lorich, Dean G; Geller, David S; Nielson, Jason H


    The treatment of intertrochanteric hip fractures has evolved over the past 80 years because of a better understanding of fracture anatomy, application of biomechanical principles, and novel technologic advances. Surgical treatment of intertrochanteric hip fractures is the current standard of care, with short-term goals of fracture stabilization and early patient mobilization and the long-term objective of restoring patients to their previous level of independence and function. Treatment for stable intertrochanteric hip fractures includes use of percutaneous intramedullary devices and open reduction and internal fixation using a sliding hip screw. To date, none of these devices has shown any clear clinical advantage over the dynamic hip screw. Intramedullary fixation has multiple theoretical advantages for the treatment of unstable fracture patterns; however, it remains unclear if ultimate functional outcome warrants the added expense of such treatment. For patients with a reverse obliquity fracture pattern, the advantage of the intramedullary construct has been shown.

  8. Animal Experimentation: Bringing Ethical Issues into Biology Teaching. (United States)

    Van Rooy, Wilhelmina


    There are many possibilities for the use of controversial issues such as animal experimentation in biology classrooms. Outlines a series of three lessons that asked senior biology students to consider the issue of animal experimentation from three perspectives. (Author/LM)

  9. Radiofrequency (mobile telephones) Exposures and Health Risks: Findings and Controversies - Linet (United States)

    Radiofrequency (mobile telephones) Exposures and Health Risks: Findings and Controversies by Dr. Martha Linet - part of the Radiation Epidemiology and Dosimetry Course on the health effects of radiation exposure

  10. [Presence of parents during dental treatment of children: a very controversial topic]. (United States)

    Boj Quesada, J R; Azanza, N


    The convenience of the presence of the parents in the dental operatory during the treatment of their children has always been controversial. This paper presents a study performed through a questionnaire regarding the topic.

  11. [Addressing the controversy regarding the association between thimerosal-containing vaccines and autism]. (United States)

    García-Fernández, Lisset; Hernández, Adrián V; Suárez Moreno, Víctor; Fiestas, Fabián


    Vaccination is one of the most important public health interventions in the reduction childhood morbidity and mortality. Thimerosal is an organic mercury compound used as preservante in multi-dose vials. Often in Peru, there are waves of controversy about the safety of this type of vaccines, mainly arguing that there is an association between them and autism. As a result of these controversies, there have been some voices asking for laws banning thimerosal-containing vaccines, which would have a large impact in costs and the logistic aspects of the public vaccination programs. The aim of this article is to review the literature for the main controversies about thimerosal in vaccines and its supposed association to autism. We made an historical review about these controversies given the available scientific evidence and the statements from important international organizations. We concluded that the current available evidence do not support an association between thimerosal and childhood neurodevelopmental disorders, such as autism.

  12. Metaphysics for an enlightened public: The controversy over monads in Germany, 1746-1748. (United States)

    Broman, Thomas


    This essay analyzes the controversy that attended the prize essay question on monads proposed by the Berlin Academy of Sciences in 1746. The controversy was first touched off by an anonymous pamphlet published by the mathematician Leonhard Euler, the academy's most well known member, that attacked the doctrine of monads. It peaked with the awarding of the prize to Johann Heinrich Gottlob Justi, whose winning essay closely followed Euler's arguments. This essay discusses the controversy as one instance in a broader quarrel in the German academic community over the suitability of Christian Wolff's philosophy as the foundation for a broad range of academic disciplines, including natural philosophy. It also analyzes the controversy as displaying the central role of the periodical press in the emergent German public sphere.



    Raluca Andreea Trandafir; Nicoleta Asalos


    The present work tackles as main theme the bookkeeping controversy, which is met when the two international audit standards are put face to face, especially IAS 16 that it refers to corporal immobilizations versus IAS 40, that it refers to an real investment. This work has as a goal the presentation and the differentiation of the bookkeeping controversy between the two audit international standards. In the first part of the work there are presented the two standards, IAS 16 corporal Immobiliz...

  14. Addressing the controversy regarding the association between thimerosal-containing vaccines and autism


    García-Fernández, Lisset; Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP), Instituto Nacional de Salud. Lima, Perú. Médica infectóloga.; Hernández, Adrián V.; Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP), Instituto Nacional de Salud. Lima, Perú. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland. Ohio, EE. UU. médico epidemiólogo clínico, PhD in Health Science.; Suárez Moreno, Víctor; Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP), Instituto Nacional de Salud. Lima, Perú. médico infectólogo, MPH in Public Health.; Fiestas, Fabián; Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP), Instituto Nacional de Salud. Lima, Perú. médico epidemiólogo.


    Vaccination is one of the most important public health interventions in the reduction childhood morbidity and mortality. Thimerosal is an organic mercury compound used as preservante in multi-dose vials. Often in Peru, there are waves of controversy about the safety of this type of vaccines, mainly arguing that there is an association between them and autism. As a result of these controversies, there have been some voices asking for laws banning thimerosal-containing vaccines, which would...

  15. Historical Controversies in Psychology: Irrational Egotistic Anomalies or Structural Stages of Rational Debate?


    Catriel Fierro


    This paper presents an empirical (historical) survey about the insertion, definition and valuation of scientific controversies in psychology on the basis of certain historiographical trends in History of Psychology. With the overall objective of reviewing the importance of controversial instances for the scientific development of psychology, and the specific objective of enabling rapprochement between the historiography of psychology and social studies of science, the definition and explanati...

  16. Actor-network Theory and cartography of controversies in Information Science


    LOURENÇO, Ramon Fernandes; TOMAÉL, Maria Inês


    Abstract The present study aims to discuss the interactions between the Actor-network Theory and the Cartography of Controversies method in Information Science research. A literature review was conducted on books, scholarly articles, and any other sources addressing the Theory-Actor Network and Cartography of Controversies. The understanding of the theoretical assumptions that guide the Network-Actor Theory allows examining important aspects to Information Science research, seeking to identif...

  17. Anatomy of a health scare: education, income and the MMR controversy in the UK


    Dan Anderberg; Arnaud Chevalier; Jonathan Wadsworth


    One theory for why there is a strong education gradient in health outcomes is that more educated individuals more quickly absorb new information about health technology. The MMR controversy in the UK provides a case where, for a brief period of time, some highly publicized research suggested that a particular multi-component vaccine, freely provided to young children, could have potentially serious side-effects. As the controversy set in, uptake of the MMR vaccine by more educated parents dec...

  18. Controversies and Evolving New Mechanisms in Subarachnoid Hemorrhage (United States)

    Chen, Sheng; Feng, Hua; Sherchan, Prativa; Klebe, Damon; Zhao, Gang; Sun, Xiaochuan; Zhang, Jianmin; Tang, Jiping; Zhang, John H.


    Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and significant health problem in the United States and worldwide. The mechanisms contributing to brain injury after SAH remain unclear. Traditionally, most in vivo research has heavily emphasized the basic mechanisms of SAH over the pathophysiological or morphological changes of delayed cerebral vasospasm after SAH. Unfortunately, the results of clinical trials based on this premise have mostly been disappointing, implicating some other pathophysiological factors, independent of vasospasm, as contributors to poor clinical outcomes. Delayed cerebral vasospasm is no longer the only culprit. In this review, we summarize recent data from both experimental and clinical studies of SAH and discuss the vast array of physiological dysfunctions following SAH that ultimately lead to cell death. Based on the progress in neurobiological understanding of SAH, the terms “early brain injury” and “delayed brain injury” are used according to the temporal progression of SAH-induced brain injury. Additionally, a new concept of the vasculo-neuronal-glia triad model for SAH study is highlighted and presents the challenges and opportunities of this model for future SAH applications. PMID:24076160

  19. Testosterone and glucose metabolism in men: current concepts and controversies. (United States)

    Grossmann, Mathis


    A wealth of observational studies show that low testosterone is associated with insulin resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental studies have identified potential mechanisms by which low testosterone may lead to insulin resistance. Visceral adipose tissue is an important intermediate in this relationship. Actions of testosterone or its metabolite oestradiol on other tissues such as muscle, liver, bone or the brain, and body composition-independent effects may also play a role. However, definitive evidence from randomised controlled trials (RCTs) to clarify whether the association of low testosterone with disordered glucose metabolism is causative is currently lacking. It therefore remains possible that this association is due to reverse causation, or simply originates by association with common health and lifestyle factors. RCTs of testosterone therapy in men with or without diabetes consistently show modest metabolically favourable changes in body composition. Despite this, testosterone effects on glucose metabolism have been inconsistent. Recent evidence suggests that the hypothalamic-pituitary-testicular axis suppression in the majority of obese men with metabolic disorders is functional, and may be, at least in part, reversible with weight loss. Until further evidence is available, lifestyle measures with emphasis on weight reduction, treatment of comorbidities and optimisation of diabetic control should remain the first-line treatment in these men. Such measures, if successful, may be sufficient to normalise testosterone levels in men with metabolic disorders, who typically have only modest reductions in circulating testosterone levels.

  20. Is healthcare providers' value-neutrality depending on how controversial a medical intervention is? Analysis of 10 more or less controversial interventions. (United States)

    Lynöe, Niels; Björk, Joar; Juth, Niklas


    Swedish healthcare providers are supposed to be value-neutral when making clinical decisions. Recent conducted studies among Swedish physicians have indicated that the proportion of those whose personal values influence decision-making (the value-influenced) vary depending on the framing and the nature of the issue. To examine whether the proportions of value-influenced and value-neutral participants vary depending on the extent to which the intervention is considered controversial. To discriminate between value-neutral and value-influenced healthcare providers, we have used the same methods in six vignette based studies including 10 more or less controversial interventions. To be controversial was understood as being an intervention where conscientious objections in healthcare have been proposed or an intervention that is against law and regulations. End of life decisions and female reproduction issues are associated with conscientious objection and more or less against regulations, and also resulted in the highest proportions of value-influenced participants. Following routines, which is not in conflict with official values, were associated with one of the lowest proportion of value-influenced participants. The difference between the highest and lowest proportions of value-influenced participants among the 10 examined interventions was significant (81.8% (95% confidence interval: 78.1-85.5) versus 34.7% (95% confidence interval: 29.2-40.2)). The study indicates that the proportions of value-neutral participants decrease the more controversial an issue is, and vice versa. In some cases, however, framing effects may potentiate or obscure this association. As a bold hypothesis, we suggest the proportion of value-neutral or value-influenced might indicate how controversial an issue is.

  1. Historical Controversies in Psychology: Irrational Egotistic Anomalies or Structural Stages of Rational Debate?

    Directory of Open Access Journals (Sweden)

    Catriel Fierro


    Full Text Available This paper presents an empirical (historical survey about the insertion, definition and valuation of scientific controversies in psychology on the basis of certain historiographical trends in History of Psychology. With the overall objective of reviewing the importance of controversial instances for the scientific development of psychology, and the specific objective of enabling rapprochement between the historiography of psychology and social studies of science, the definition and explanation given about historical controversies by the classic historiography of psychology are first described, emphasizing the anomalous character of such controversies to said historiography given the implicit theoretical and methodological principles of such tradition. The redefinition of historical controversies by the ‘new history’ of psychology developed since 1970 is then detailed. It is noted that such redefinition took place partly due to the historians’ incorporation of certain sociological and socio-historical principles and explanatory resources from social history of science and social studies of science. The positive character of such a redefinition and of the foresight of deeper socio-historical analysis of controversies in psychology is then concluded.

  2. Turkish Social Studies Teachers’ Thoughts About the Teaching of Controversial Issues

    Directory of Open Access Journals (Sweden)

    Ahmet Copur


    Full Text Available In today’s world, one of the primary goals of education is to raise individuals as citizens equipped with the skills of communication, high-level thinking, problem solving and questioning as well as with a global viewpoint. Introducing controversial issues into the classroom environment may be among the steps to be taken to achieve these goals. In this context, this study has the primary goal of revealing Social Studies teachers’ thoughts about the teaching of controversial issues in the classroom environment. This study adopted mixed methods. The study participants consisted of Social Studies teachers working in Bursa, which is a large-scale province of Turkey, in the 2014-2015 school year. According to the study findings, while terror was the most controversial issue, faith in creation was the least controversial issue. In addition, teachers mainly preferred to introduce issues related to the Social Studies curriculum and that were appropriate for the students’ preparedness. However, another result is that controversial issues contributed to students’ acquisition of personal critical skills such as high-level thinking and communication. It was also observed that the teaching of controversial issues was related to the Social Studies lesson and was important for the achievement of the goals of the lesson.

  3. Androgen replacement therapy in late-onset hypogonadism: current concepts and controversies - a mini-review. (United States)

    Mäkinen, Juuso I; Huhtaniemi, Ilpo


    Normal testicular function is essential for the maintenance of male physical strength and behaviour irrespective of age. A new term of late-onset hypogonadism (LOH) has been coined for the condition of decreased testosterone (T) and hypogonadal symptoms in ageing men. The most important testicular hormone, T, is responsible for the gender-specific androgenic-anabolic effects in men. Testicular T production remains stable until around the age of 40 years after which it declines by 1-2% annually. Despite this age-related decline, serum T levels in most older men remain within the reference range of younger men. The decreasing androgen levels are paralleled by well-defined objective biological and nonspecific subjective signs and symptoms of ageing. Because these symptoms are similar to those observed in young men with documented hypogonadism, androgen replacement therapy (ART) has been considered a logical way to treat them. A thorough review of the existing literature was performed to evaluate the current concepts and controversies related to ageing men and ART. Although it is intuitively logical that the symptoms of LOH are due to the ageing-related deficiency of T, and that they can be reversed by ART, the evidence for this is still variable and often weak. In particular, evidence-based information about long-term benefits and risks of ART in ageing men is largely missing. Despite widespread use, evidence-based proof for the objective benefits and side effects of ART of elderly men is still scanty, and such treatments should be considered experimental. Copyright © 2010 S. Karger AG, Basel.

  4. Post-Fukushima Japan: The continuing nuclear controversy

    International Nuclear Information System (INIS)

    Fam, Shun Deng; Xiong, Jieru; Xiong, Gordon; Yong, Ding Li; Ng, Daniel


    The Fukushima disaster was a wake-up call for the nuclear industry as well as a shocking revelation of the inner workings of the Japanese power sector. The political fallout from the event was far-reaching, pushing governments into abandoning nuclear expansion, turning instead to fossil fuels and renewable energy alternatives. While the move away from nuclear energy was deemed a move critical to political survival in Europe, we find that political candidates running on anti-nuclear platforms did not win elections, while the pro-nuclear Liberal Democratic Party won government in the 2012 elections. Against this backdrop, we analyse the energy conflict in Japan using a framework of values versus interests and consider the regulatory and cultural conditions that contributed to the disaster. A number of considerations lie in the way of an organised phase-out of nuclear power in Japan. We also consider the possible policy paths Japan may take. - Highlights: • As Europeans urgently phase-out nuclear power, Japan voted out such a government despite high anti-nuclear sentiment. • Regulatory climate within the nuclear industry was dysfunctional as a result of being captured by the ‘nuclear village’. • New ‘independent’ nuclear authority is made up of previously captured agency. • With a pro-nuclear government, and lack of really independent nuclear authority, old problems may yet arise. • Japanese government has to choose between lowering emissions, low popular support for nuclear power, and affordable electricity

  5. Open Versus Closed Laparoscopy: Yet an Unresolved Controversy. (United States)

    Taye, Milan Kumar; Fazal, Syed Abul; Pegu, David; Saikia, Dayanada


    Safe placement of the Verres needle or the primary trocar for establishment of pneumoperitoneum is the most critical step in laparoscopic procedure as it is associated with bowel, bladder and life threatening vascular injuries and embolism. In the last few decades many techniques and guidelines have been introduced to eliminate complications in creation of pneumoperitoneum. Classical closed technique (Verres needle) and the open classic technique (Hasson) are the most commonly used techniques for creation of pneumoperitoneum. To compare the rate of occurrence and nature of complications in open and closed laparoscopy during establishment of pneumoperitoneum in different surgical and gynaecological procedures. This was a comparative study conducted at three hospitals in Dibrugarh district, Assam, India from January 2012 to December 2014. Total 3000 cases were included in the study with 1500 cases of open laparoscopy and 1500 cases of closed laparoscopy. Complications occurring in both the groups were compared by using Fisher's-exact test. In closed laparoscopy group minor complications occurred in 80 (5.33%) and major complications in 20 (1.33%) cases. In open laparoscopy group minor complications were observed in 60 (4%) and major complications in 2 (0.13%). The p-value of the difference between the two groups for minor complications was 0.0834 and for major complications was 0.0001(significant). Open laparoscopy was seen to be better than closed laparoscopy in terms of not only the rate of occurrence of complications but also the nature and severity of the complications. This study is clinically relevant as there is no consensus for a particular method of safe entry in to the peritoneal cavity warranting the need for more research. Open technique can be performed in all cases irrespective of previous operative scar, suspected intra peritoneal adhesions or obesity. Favourable outcome may be achieved in closed technique in cases of normal BMI, absence of

  6. Contralateral testicular biopsy in testis cancer: current concepts and controversies. (United States)

    Heidenreich, Axel


    Of all patients with unilateral testis cancer, approximately 5% harbour testicular intraepithelial neoplasia (TIN) in their contralateral testicle that will progress into an invasive germ cell tumour over time. The accurate diagnosis of TIN by a random two-site surgical testis biopsy and effective therapy by local radiation has led to the concept of a contralateral screening biopsy in all patients with testis cancer. However, screening and preventive treatment are only indicated if the therapeutic outcome of the screened population is improved, and the physiological function of the affected organ is not impaired. Based on a critical review of previous reports, some drawbacks of this policy have to be considered and question the routine indication for contralateral testis biopsy: (i) all TIN-negative patients still have to undergo meticulous follow-up for metachronous testis cancer due to a false negative biopsy rate of 0.5-1.0%; (ii) local radiation of TIN results in irreversible infertility due to eradication of spermatogenesis; (iii) local radiation of TIN results in an impairment of endocrine Leydig cell function in 25% of the patients; (iv) therapeutic outcome and prognosis will not be improved in irradiated patients as compared to patients on surveillance; (v) local tumour resection for the management of metachronous testicular cancer represents an effective and viable option. Current reports do not support the strategy of contralateral testis biopsy in all patients with unilateral testicular germ cell tumours. According to the recommendations of the European Germ Cell Cancer Consensus Group, a testis biopsy might be offered to high-risk patients for contralateral TIN (testicular volume <12 mL, history of cryptorchidism, age <30 years).

  7. General practitioners' perceptions of vaccination controversies: a French nationwide cross-sectional study. (United States)

    Le Marechal, M; Fressard, L; Agrinier, N; Verger, P; Pulcini, C


    We aimed to study general practitioners' (GPs') perceptions of vaccines that have been a subject of controversy in France. A cross-sectional survey in 2014 asked a representative national sample of GPs, randomly selected from the exhaustive database of health professionals in France, about their perceptions of the likelihood of serious adverse events potentially associated with six different vaccines: for two of them the association was based on some scientific evidence, whereas for the other four this is not the case. We performed a cluster analysis to construct a typology of GPs' perceptions about the likelihood of these potential six associations. Factors associated with certain clusters of interest were identified using logistic regression models. Overall, 1582 GPs participated in the questionnaire survey (1582/1712 GPs who agreed to participate, 92%). Cluster analysis identified four groups of GPs according to their susceptibility to vaccine controversies: 1) limited susceptibility to controversies (52%); 2) overall unsure, but rejected the association between hepatitis B vaccine and multiple sclerosis (32%); 3) highly susceptible to controversies (11%); and 4) unsure (5%). We found that GPs who occasionally practised alternative medicine (OR 2.71, 95% CI 1.65-4.45), and those who considered information provided by mass media as reliable (OR 2.04, 95% CI 1.65-3.99) were more susceptible to controversies. GPs had different profiles of susceptibility to vaccination controversies, and most of their perceptions of these controversies were not based on scientific evidence. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  8. 22 CFR 40.91 - Certain aliens previously removed. (United States)


    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a result...

  9. Pivotal debates and controversies on the structure and function of the avian respiratory system: setting the record straight. (United States)

    Maina, John N


    Among the extant air-breathing vertebrates, the avian respiratory system is structurally the most complex and functionally the most efficient gas exchanger. Having been investigated for over four centuries, some aspects of its biology have been extremely challenging and highly contentious and others still remain unresolved. Here, while assessing the most recent findings, four notable aspects of the structure and function of the avian respiratory system are examined critically to highlight the questions, speculations, controversies and debates that have arisen from past research. The innovative techniques and experiments that were performed to answer particular research questions are emphasised. The features that are outlined here concern the arrangement of the airways, the path followed by the inspired air, structural features of the lung and the air and blood capillaries, and the level of cellular defence in the avian respiratory system. Hitherto, based on association with the proven efficiency of naturally evolved and human-made counter-current exchange systems rather than on definite experimental evidence, a counter-current gas exchange system was suggested to exist in the avian respiratory system and was used to explain its exceptional efficiency. However, by means of an elegant experiment in which the direction of the air-flow in the lung was reversed, a cross-current system was shown to be in operation instead. Studies of the arrangement of the airways and the blood vessels corroborated the existence of a cross-current system in the avian lung. While the avian respiratory system is ventilated tidally, like most other invaginated gas exchangers, the lung, specifically the paleopulmonic parabronchi, is ventilated unidirectionally and continuously in a caudocranial (back-to-front) direction by synchronized actions of the air sacs. The path followed by the inspired air in the lung-air sac system is now known to be controlled by a mechanism of aerodynamic valving

  10. Early Controversies over Athetosis: I. Clinical Features, Differentiation from other Movement Disorders, Associated Conditions, and Pathology

    Directory of Open Access Journals (Sweden)

    Douglas J. Lanska


    Full Text Available Background: Since the description of athetosis in 1871 by American neurologist William Alexander Hammond (1828-1900 the disorder has been a source of controversy, as were many aspects of Hammond’s career.  Methods: Review of controversies in the semi-centennial since the description of athetosis.  Results: Hammond struggled to establish athetosis as a distinct clinic-pathological entity, and had successfully predicted the striatal pathology in his initial case (albeit somewhat serendipitously.  Athetosis was, nevertheless, considered by many neurologists to be a form of post-hemiplegic chorea or part of a continuum between chorea and dystonia. European neurologists, and particularly the French, initially ignored or discounted the concept. Additional controversies arose over whether the movements persisted during sleep, whether athetosis was, or could be, associated with imbecility or insanity, and how it should be treated. Discussion: Some controversies concerning athetosis served to identify areas where knowledge was insufficient to make accurate statements, despite prior self-assured or even dogmatic statements to the contrary.  Other controversies illustrated established prejudices, even if these biases were often only apparent with the greater detachment of hindsight. 

  11. Determining root correspondence between previously and newly detected objects (United States)

    Paglieroni, David W.; Beer, N Reginald


    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  12. Experimental Methods in Psychology and Cognitive and Affective Neuroscience

    DEFF Research Database (Denmark)

    Habekost, Thomas; Nielsen, Julie Hassing


    Laboratory experiments have always been important in psychology and are as commonly used today as ever due to the dominating position of cognitive research in international psychology. This trend has been further strengthened by recent developments in cognitive neuroscience, where experimental...... studies are central. Recently, experimental studies within the field of affective neuroscience have also received attention. Notwithstanding, experimental methods remain controversial also in psychology, and one should carefully weigh their advantages against their drawbacks....

  13. Does Controversial Science Call For Public Participation? The Case Of Gmo Skepticism

    Directory of Open Access Journals (Sweden)

    Andreas Christiansen


    Full Text Available Many instances of new and emerging science and technology are controversial. Although a number of people, including scientific experts, welcome these developments, a considerable skepticism exists among members of the public. The use of genetically modified organisms (GMOs is a case in point. In science policy and in science communication, it is widely assumed that such controversial science and technology require public participation in the policy-making process. We examine this view, which we call the Public Participation Paradigm, using the case of GMOs as an example. We suggest that a prominent reason behind the call for public participation is the belief that such participation is required for democratic legitimacy. We then show that the most prominent accounts of democratic legitimacy do not, in fact, entail that public participation is required in cases of controversial science in general, or in the case of GMOs in particular.

  14. Topical therapy of atopic dermatitis: controversies from Hippocrates to topical immunomodulators. (United States)

    Tilles, Gérard; Wallach, Daniel; Taïeb, Alain


    Although atopic dermatitis can be treated efficiently, there is still much controversy about the risk/benefit ratio of both topical corticosteroids and topical immunomodulators. Conflicting data may be found about the usefulness of bathing, diet regulation, and other therapeutic interventions. These controversies result in part from the persistence of Hippocratic doctrines in modern medical thinking. Humoralist and diathetic doctrines, as they pertain to eczema, are reviewed. The paradoxical worsening of oozing and the deadly hazards of hospitalization before the era of antibiotics are brought to mind. We hope that this historical review will improve the understanding of current controversies and help dermatologists to manage patients with atopic dermatitis and other chronic skin diseases.

  15. Adjunctive use of the diode laser in non-surgical periodontal therapy: exploring the controversy. (United States)

    Porteous, Mary Sornborger; Rowe, Dorothy J


    Despite the controversy regarding clinical efficacy, dental hygienists use the diode laser as an adjunct to non-surgical periodontal therapy. The technique to maximize successful laser therapy outcome is controversial as well. The purpose of this review is to explore the scientific foundation of the controversy surrounding the use of the diode laser as an adjunct to non-surgical periodontal therapy. Further, this paper addresses the weaknesses in study design, the heterogeneity of methodology in the published clinical studies, especially the laser parameters, and how these issues impact the collective clinical and microbial data, and thus conclusions regarding clinical efficacy. Evaluation of the literature identifies possible mechanisms that could contribute to the varied, often conflicting results among laser studies that are the foundation of the controversy surrounding clinical efficacy. These mechanisms include current paradigms of periodontal biofilm behavior, tissue response to laser therapy being dependent on tissue type and health, and that the successful therapeutic treatment window is specific to the target tissue, biofilm composition, laser wavelength, and laser energy delivered. Lastly, this paper discusses laser parameters used in the various clinical studies, and how their diversity contributes to the controversy. Although this review does not establish clinical efficacy, it does reveal the scientific foundation of the controversy and the need for standardized, well designed randomized controlled clinical trials to develop specific guidelines for using the laser as an adjunct to non-surgical periodontal therapy. Using evidence-based laser guidelines would allow dental hygienists to provide more effective non-surgical periodontal care.

  16. Non-invasive brain stimulation for food cravings, consumption, and disorders of eating: A review of methods, findings and controversies. (United States)

    Hall, Peter A; Vincent, Corita M; Burhan, Amer M


    To describe the state of the human research literature pertaining to the use of non-invasive brain stimulation (NIBS) procedures for modulating food cravings, food consumption, and treating disorders of eating (i.e., obesity, bulimia nervosa, and anorexia nervosa). A narrative review of methods, empirical findings, and current areas of controversy. Both single-session experimental and multi-session therapeutic modalities are considered, separately for repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) technologies. Single-session studies involving NIBS report more consistent effects of rTMS than tDCS, but this advantage is more clear in relation to food cravings than actual food consumption. Multisession therapeutic approaches have been applied to both obesity and eating disorders. With respect to obesity, the three published (tDCS) and one ongoing trial (rTMS) have yielded promising though very preliminary findings. Application of multi-session NIBS (predominantly rTMS) to eating disorders has also yielded promising but ultimately inconclusive results, both in relation to bulimia nervosa and binge eating disorder. Findings regarding excitatory NIBS in the context of anorexia are more controversial, with evidence of improvement in affective functioning, but a trend of iatrogenic weight loss. Excitatory NIBS-particularly rTMS-can reliably reduce food cravings in single and multi-session format. For multi-session treatment of clinical conditions, more studies are needed for both rTMS and tDCS, particularly in relation to obesity, bulimia, and binge eating disorder. Application of NIBS for anorexia is less clear at this point, and excitatory NIBS may be contraindicated on theoretical and empirical grounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. [Foucault, Derrida, and the history of madness: notes on a controversy]. (United States)

    Pereira Neto, A F


    The publication of the book Folie et Déraison. Histoire de la Folie à l'Age Classique (1961), by Michel Foucault, sparked a debate between the author and philosopher Jacques Derrida during the 1960s and 70s. Derrida criticized the methodological proposal and organization of the History of Madness presented by Foucault in the foreword to the first edition. The controversy appears to have motivated the author to withdraw this same foreword from the second edition. The purpose of this article is to analyze some current points in this controversy. It also presents a research agenda for an understanding of the reasons leading Foucault to take this stance.

  18. Sentencing and Other Controversial Issues: Why We Need Rational Debate More Than Ever

    Directory of Open Access Journals (Sweden)

    Ian Gray


    Full Text Available The article seeks to demonstrate the importance of rational debate in the community on controversial issues. It focuses on the need for rationalism to prevail in community debates on controversial issues. Issues inclusive of sentencing, climate change, mental health and its prevalence in the prison system and ‘whether courts are out of touch’ with the community. The article recognises the difficulties faced by those engaged in community issues and concludes by promoting the need to maintain a tolerant and harmonious society by engaging in well informed rational debate.

  19. Einstein's opponents the public controversy about the theory of relativity in the 1920s

    CERN Document Server

    Wazeck, Milena


    This detailed account of the controversy surrounding the publication of Albert Einstein's theory of relativity explores the ferocious popular and academic opposition which at one time encircled one of the most important scientific breakthroughs of the twentieth century. Based on extensive archival research, this fascinating discourse includes a compelling and entertaining examination of the contemporary literature created by Einstein's detractors. Exploring the arguments and strategies, social contexts, and motivations of Einstein's detractors, and providing unique insights into the dynamics of scientific controversies, this book is ideal for anyone interested in the history and philosophy of physics, popular science, and the public understanding of science.

  20. Proton beam therapy for localized prostate cancer 101: basics, controversies, and facts. (United States)

    Wisenbaugh, Eric S; Andrews, Paul E; Ferrigni, Robert G; Schild, Steven E; Keole, Sameer R; Wong, William W; Vora, Sujay A


    Proton beam therapy for prostate cancer has become a source of controversy in the urologic community, and the rapid dissemination and marketing of this technology has led to many patients inquiring about this therapy. Yet the complexity of the technology, the cost, and the conflicting messages in the literature have left many urologists ill equipped to counsel their patients regarding this option. This article reviews the basic science of the proton beam, examines the reasons for both the hype and the controversy surrounding this therapy, and, most importantly, examines the literature so that every urologist is able to comfortably discuss this option with inquiring patients.

  1. Effects of low-level blast exposure on the nervous system: Is there really a controversy?

    Directory of Open Access Journals (Sweden)

    Gregory A Elder


    Full Text Available High-pressure blast waves can cause extensive CNS injury in humans. However, in combat settings such as Iraq and Afghanistan, lower level exposures associated with mild TBI (mTBI or subclinical exposure have been much more common. Yet controversy exists concerning what traits can be attributed to low-level blast, in large part due to the difficulty of distinguishing blast-related mTBI from post-traumatic stress disorder (PTSD. We describe how TBI is defined in humans and the problems posed in using current definitions to recognize blast-related mTBI. We next consider the problem of applying definitions of human mTBI to animal models, in particular that TBI severity in humans is defined in relation to alteration of consciousness at the time of injury, which typically cannot be assessed in animals. However, based on outcome assessments a condition of low-level blast exposure can be defined in animals that likely approximates human mTBI or subclinical exposure. We review blast injury modeling in animals noting that inconsistencies in experimental approach have contributed to uncertainty over the effects of low-level blast. Yet animal studies show that low-level blast pressure waves are transmitted to the brain. In brain low-level blast exposures cause behavioral, biochemical, pathological and physiological effects on the nervous system including the induction of PTSD-related behavioral traits in the absence of a psychological stressor. We review the relationship of blast exposure to chronic neurodegenerative diseases noting the paradoxical lowering of Abeta by blast, which along with other observations suggest that blast-related TBI is pathophysiologically distinct from non-blast TBI. Human neuroimaging studies show that blast-related mTBI is associated with a variety of chronic effects that are unlikely to be explained by co-morbid PTSD. We conclude that abundant evidence supports low-level blast as having long-term effects on the nervous system.

  2. Tektite controversy

    International Nuclear Information System (INIS)

    Davis, J.


    Clues as to the possible origin of tektites are found by studying the chemical composition, sites where they are found, and shapes. An important chemical fact of tektites is that they are extremel dry. Tektites lie in four major areas and in three isolated regions. They are distributed as if they fell from the skies. By studying the flanged shapes of the australites, it was concluded that their shape was due to a fast, hot trip through the atmosphere. Tektites show no cosmic ray tracks which implies their space exposure time was short. This rules out the possibility that they are a form of meteorite with these clues in mind, four theories on their possible origin are discussed in this paper. The theories are: (1) terrestial impact by meteorite or comet; (2) lunar impact; (3) terrestial volcanoes; and (4) lunar volcanoes. This article rules out the first three theories for reasons which are given and leans toward the fourth theory as the most probable of the four

  3. Constructive Controversy

    DEFF Research Database (Denmark)

    Kock, Christian Erik J


    Current theories of argumentation underestimate the difference, emphasized already by Aristotle, between theoretical and practical (action-oriented) argumentation. This is exemplified with the argument theories of Toulmin, pragma-dialectics, Habermas, Walton, and Perelman. Since antiquity, rhetor......, but also inside each individual, several conflicting value dimensions are typically involved, not just the dimension of truth-falsity, which makes sustained, reasonable dissensus inevitable....

  4. Female rose bitterling prefer MHC-dissimilar males: experimental evidence.

    Directory of Open Access Journals (Sweden)

    Martin Reichard

    Full Text Available The role of genetic benefits in female mate choice remains a controversial aspect of sexual selection theory. In contrast to "good allele" models of sexual selection, "compatible allele" models of mate choice predict that females prefer mates with alleles complementary to their own rather than conferring additive effects. While correlative results suggest complementary genetic effects to be plausible, direct experimental evidence is scarce. A previous study on the Chinese rose bitterling (Rhodeus ocellatus demonstrated a positive correlation between female mate choice, offspring growth and survival, and the functional dissimilarity between the Major Histocompatibility Complex (MHC alleles of males and females. Here we directly tested whether females used cues associated with MHC genes to select genetically compatible males in an experimental framework. By sequentially pairing females with MHC similar and dissimilar males, based on a priori known MHC profiles, we showed that females discriminated between similar and dissimilar males and deposited significantly more eggs with MHC dissimilar males. Notably, the degree of dissimilarity was an important factor for female decision to mate, possibly indicating a potential threshold value of dissimilarity for decision making, or of an indirect effect of the MHC.

  5. Genetic insights into age-related macular degeneration: Controversies addressing Risk, Causality, and Therapeutics (United States)

    Gorin, Michael B.


    Age-related macular degeneration (AMD) is a common condition among the elderly population that leads to the progressive central vision loss and serious compromise of quality of life for its sufferers. It is also one of the few disorders for whom the investigation of its genetics has yielded rich insights into its diversity and causality and holds the promise of enabling clinicians to provide better risk assessments for individuals as well as to develop and selectively deploy new therapeutics to either prevent or slow the development of disease and lessen the threat of vision loss. The genetics of AMD began initially with the appreciation of familial aggregation and increase risk and expanded with the initial association of APOE variants with the disease. The first major breakthroughs came with family-based linkage studies of affected (and discordant) sibs, which identified a number of genetic loci and led to the targeted search of the 1q31 and 10q26 loci for associated variants. Three of the initial four reports for the CFH variant, Y402H, were based on regional candidate searches, as were the two initial reports of the ARMS2/HTRA1 locus variants. Case-control association studies initially also played a role in discovering the major genetic variants for AMD, and the success of those early studies have been used to fuel enthusiasm for the methodology for a number of diseases. Until 2010, all of the subsequent genetic variants associated with AMD came from candidate gene testing based on the complement factor pathway. In 2010, several large-scale genome-wide association studies (GWAS) identified genes that had not been previously identified. Much of this historical information is available in a number of recent reviews.(Chen et al., 2010b; Deangelis et al., 2011; Fafowora and Gorin, 2012b; Francis and Klein, 2011; Kokotas et al., 2011) Large meta analysis of AMD GWAS has added new loci and variants to this collection.(Chen et al., 2010a; Kopplin et al., 2010; Yu et

  6. 2 CFR 1.215 - Relationship to previous issuances. (United States)


    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuances. 1.215 Section 1.215 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction toSubtitle A § 1.215 Relationship to previous issuances. Although some of the guidance was...

  7. 2 CFR 230.45 - Relationship to previous issuance. (United States)


    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuance. 230.45 Section 230.45 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR NON-PROFIT ORGANIZATIONS (OMB CIRCULAR A-122) § 230.45 Relationship to previous issuance. (a...

  8. Research Note Effects of previous cultivation on regeneration of ...

    African Journals Online (AJOL)

    Research Note Effects of previous cultivation on regeneration of Julbernadia globiflora and Brachystegia spiciformis in grazing areas of Mupfurudzi ... Plant attributes for Julbernadia globiflora and Brachystegia spiciformis were measured in previously cultivated and uncultivated sites making up rangelands of the scheme.

  9. 49 CFR 173.23 - Previously authorized packaging. (United States)


    ... 49 Transportation 2 2010-10-01 2010-10-01 false Previously authorized packaging. 173.23 Section... REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Preparation of Hazardous Materials for Transportation § 173.23 Previously authorized packaging. (a) When the regulations specify a packaging with a specification marking...




  11. Triple outlet right ventricle: a previously unknown cardiac malformation. (United States)

    Tingo, Jennifer E; Carroll, Sheila J; Crystal, Matthew A


    We present the case of an infant with three distinct outflow tracts from the right ventricle. Three outlets from the heart have been previously named the "Tritruncal Heart". We review the two previously reported cases of tritruncal hearts and describe the anatomy, diagnosis, surgical management, and outcome of our case. Embryologic implications are also discussed.

  12. Implant breast reconstruction after salvage mastectomy in previously irradiated patients. (United States)

    Persichetti, Paolo; Cagli, Barbara; Simone, Pierfranco; Cogliandro, Annalisa; Fortunato, Lucio; Altomare, Vittorio; Trodella, Lucio


    The most common surgical approach in case of local tumor recurrence after quadrantectomy and radiotherapy is salvage mastectomy. Breast reconstruction is the subsequent phase of the treatment and the plastic surgeon has to operate on previously irradiated and manipulated tissues. The medical literature highlights that breast reconstruction with tissue expanders is not a pursuable option, considering previous radiotherapy a contraindication. The purpose of this retrospective study is to evaluate the influence of previous radiotherapy on 2-stage breast reconstruction (tissue expander/implant). Only patients with analogous timing of radiation therapy and the same demolitive and reconstructive procedures were recruited. The results of this study prove that, after salvage mastectomy in previously irradiated patients, implant reconstruction is still possible. Further comparative studies are, of course, advisable to draw any conclusion on the possibility to perform implant reconstruction in previously irradiated patients.

  13. No discrimination against previous mates in a sexually cannibalistic spider (United States)

    Fromhage, Lutz; Schneider, Jutta M.


    In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.

  14. Thyroid disease awareness is associated with high rates of identifying subjects with previously undiagnosed thyroid dysfunction. (United States)

    Canaris, Gay J; Tape, Thomas G; Wigton, Robert S


    Conventional screening for hypothyroidism is controversial. Although hypothyroidism is underdiagnosed, many organizations do not recommend screening, citing low disease prevalence in unselected populations. We studied attendees at a thyroid health fair, hypothesizing that certain patient characteristics would enhance the yield of testing. We carried out an observational study of participants at a Michigan health fair that focused on thyroid disease. We collected patient-reported symptoms and demographics by questionnaire, and correlated these with the TSH values obtained through the health fair. 794 of 858 health fair attendees participated. Most were women, and over 40% reported a family history of thyroid disease. We identified 97 (12.2%) participants with previously unknown thyroid dysfunction. No symptom or combination of symptoms discriminated between hypothyroid and euthyroid individuals. Hypothyroid and euthyroid participants in the health fair reported each symptom with a similar prevalence (p > 0.01), a prevalence which was very high. In fact, when compared with a previously published case-control study that reported symptoms, the euthyroid health fair participants reported a higher symptom prevalence (range 3.9% to 66.3%, mean 31.5%), than the euthyroid individuals from the case-control study (range 2% to 54%, mean 17.4%). A high proportion of previously undiagnosed thyroid disease was identified at this health fair. We initially hypothesized symptoms would distinguish between thyroid function states. However, this was not the case in this health fair screening population. The prevalence of reported symptoms was similar and high in both euthyroid and hypothyroid participants. Because attendees were self-selected, it is possible that this health fair that focused on thyroid disease attracted participants specifically concerned about thyroid health. Despite the lack of symptom discrimination, the much higher prevalence of hypothyroidism in this study

  15. Effect of Genotype and Previous GH Treatment on Adiposity in Adults With Prader-Willi Syndrome. (United States)

    Coupaye, Muriel; Tauber, Maithé; Cuisset, Laurence; Laurier, Virginie; Bieth, Eric; Lacorte, Jean-Marc; Oppert, Jean-Michel; Clément, Karine; Poitou, Christine


    Adults with Prader-Willi syndrome (PWS) have an increased proportion of sc fat mass compared with body mass index (BMI)-matched controls, but whether the genotype influences body composition and metabolic profile remains controversial. To assess body composition and metabolic features in adults with PWS, according to genetic subtype. In addition, the effect of previous GH treatment was assessed. Main Outcomes and Measures: Body composition (Dual Energy X-ray Absorptiometry) and metabolic parameters were compared in PWS adults (mean age, 25.5 ± 8.9 y) with deletion (n = 47) or uniparental disomy (UPD) (n = 26), taking into account GH treatment in childhood and/or adolescence. In subgroups, adipocyte size, fasting total ghrelin levels, and resting energy expenditure were measured, and hyperphagia was assessed by the Dykens Hyperphagia Questionnaire. In the whole sample, the deletion group had a higher BMI compared with UPD (40.9 ± 11.5 vs 34.6 ± 9.6 kg/m 2 , P = .02), but there was no difference between groups in percent body fat, metabolic profile, adipocyte size, resting energy expenditure, hyperphagia score, or ghrelin levels. In subjects previously treated with GH, BMI was not different between UPD and deletion groups (33.0 ± 9.7 vs 33.5 ± 11.1 kg/m 2 ). In addition, previous GH treatment was associated with decreased percent body fat and adipocyte volume only in the deletion group. A deletion genotype in adults with PWS is associated with increased BMI. GH treatment in childhood and/or adolescence limits this deleterious phenotypic effect with improved adiposity markers. This study suggests relationships between the molecular phenotype of PWS and adipose tissue development as well as sensitivity to GH.

  16. Clinical Correlates of Alleged Satanic Abuse and Less Controversial Sexual Molestation. (United States)

    Leavitt, Frank


    This study found that 39 women alleging satanic ritual abuse and 47 women reporting less controversial forms of sexual trauma as children were characterized by high but nondiscriminating levels of psychiatric pathology. Patients alleging satanic ritual abuse reported higher levels of dissociation, in the range often exhibited by patients with…

  17. Singapore Teachers' Beliefs about the Purpose of Climate Change Education and Student Readiness to Handle Controversy (United States)

    Seow, Tricia; Ho, Li-Ching


    This qualitative study examines what four pre-service and six practicing geography educators in Singapore schools believe to be the purpose of climate change education, and how this intersects with their beliefs about student readiness to handle controversy within climate change education. A key finding of this study indicates that the teachers'…

  18. Old and New Controversies in the Alternative Treatment of Attention-Deficit Hyperactivity Disorder (United States)

    Rojas, Neal L.; Chan, Eugenia


    Use of complementary and alternative medicine (CAM) for treatment of attention-deficit hyperactivity disorder (ADHD) has become widespread in both referral and primary care populations. We review the purported mechanism of action and available evidence for selected CAM therapies for ADHD. Enduring controversies, such as elimination of artificial…

  19. Denver's airport of doom; the story behind the world's possibly most controversial airport

    NARCIS (Netherlands)

    Stolwijk, J.


    Big airport projects have often been prone to controversy. Schiphol’s Polderbaan project, Heathrow’s expansion, and the construction of Berlin’s new airport all suffered from political, financial or technical issues. However, Denver International Airport (often referred to as DIA) caused uproar in

  20. Controversial Practices: The Need for a Reacculturation of Early Intervention Fields. (United States)

    McWilliam, R. A.


    Identifies characteristics (such as cure claims, practitioner specialization, and questionable research) of controversial practices in early intervention. Evaluates 13 such practices grouped into medical, educational, and therapeutic categories and suggests reasons that professionals and parents adopt such practices. Suggestions for the field…


    Directory of Open Access Journals (Sweden)

    I. O. Perepechina


    Full Text Available The paper presents the analysis of the statistical data on the Russian Federation, showing how often controversy and conflicts due to improper medical care occurs in medical practice, as well as what are the ways to resolve them.

  2. From Iconoclasm to Arianism: The Construction of Christian Tradition in the Iconoclast Controversy

    Directory of Open Access Journals (Sweden)

    David M. Gwynn


    Full Text Available The defenders of icons in the eighth and ninth centuries, especially Photius, significantly reinterpreted the fourth-century Arian controversy and the views of Eusebius in order to link the Iconoclasts to the Arians and themselves to Church fathers like Athanasius.

  3. An Analysis of Selected Biology Textbooks for the Treatment of Controversial Issues and Biosocial Problems. (United States)

    Levin, Florence S.; Lindbeck, Joy S.


    Analyzes five biology textbooks in 11 categories identified as current controversial issues and biosocial problems. Quantitative ratings for each category, based on total number of textbook pages, are presented for Darwinian evolution, disease states, drugs, environment, human genetics, human reproduction, man in nature, origin of life, population…

  4. Academic Controversy in Macroeconomics: An Active and Collaborative Method to Increase Student Learning (United States)

    Santicola, Craig F.


    The literature indicates that there is a lack of learning outcomes in economics that can be attributed to the reliance on traditional lecture and the failure to adopt innovative instructional techniques. This study sought to investigate the student learning effects of academic controversy, a cooperative learning technique that shows promise in the…

  5. Controversy and consensus on a clinical pharmacist in primary care in the Netherlands

    NARCIS (Netherlands)

    A.C.M. Hazen (Ankie); Wal, A.W.V.D. (Aletta W. Van Der); V.M. Sloeserwij (Vivianne); D.L.M. Zwart (Dorien); Gier, J.J.D. (Johan J. De); Wit, N.J.D. (Niek J. De); A.J. Leendertse (Anne); M.L. Bouvy (Marcel); A.A. de Bont (Antoinette)


    textabstractBackground Controversy about the introduction of a non-dispensing pharmacist in primary care practice hampers implementation. Objective The aim of this study is to systematically map the debate on this new role for pharmacists amongst all stakeholders to uncover and understand the

  6. Professional Controversies between Teachers about Their Summative Assessment Practices: A Tool for Building Assessment Capacity (United States)

    Mottier Lopez, Lucie; Pasquini, Raphaël


    This article describes two collaborative research projects whose common goal was to explore the potential role of professional controversies in building teachers' summative assessment capacity. In the first project, upper primary teachers were encouraged to compare their practices through a form of social moderation, without prior instructor input…

  7. Representing New Math: Genre Chains and Controversy in the Saskatchewan Media (United States)

    LeBlanc, Robert J.


    The media's response to the release of "Math Instruction that Makes Sense" (2011), a research report by the Frontier Centre for Public Policy (FCPP), helped spark a public controversy and spur the Saskatchewan government to reexamine the Ministry of Education's math curriculum. The purpose of this article is to examine the CBC's…

  8. The Safford, Arizona, Murals of Seymour Fogel: A Study in Artistic Controversy. (United States)

    Fogel, Jared A.; Stevens, Robert L.


    Examines the controversy generated by art works commissioned by the Works Progress Administration (WPA). Attempting to create work for depression-era artists, the WPA often commissioned murals for government buildings. Recounts the experience of Seymour Fogel, who's positive portrayal of Native Americans ran afoul of racist sentiments in Safford,…

  9. Digitally mediated publics: The case of the Copenhagen ‘payment ring’ controversy

    DEFF Research Database (Denmark)

    Birkbak, Andreas

    The aim of this paper is to discuss the concept of digitally mediated publics and outline a research strategy for investigating such publics, drawing on the Copenhagen road pricing controversy as a useful empirical case. The discussion takes Marres’ (2005) concept of issue publics as its vantage...

  10. Science and Social Studies Teachers' Beliefs and Practices about Teaching Controversial Issues: Certain Comparisons (United States)

    Kus, Zafer


    The current study aims to investigate social studies and science teachers' attitudes and classroom practices associated with controversial issues. The study is a qualitative research based on data collected through interviews and observation. Social studies and Science teachers participated in the current study which was conducted in Kirsehir, a…

  11. The Intellectual Roots of the Controversy around Cultural Diversity and Political Correctness. (United States)

    Tripp, Luke


    Focuses on the intellectual history of American higher education and how it has shaped the current issues around cultural diversity and political correctness. Shows how a major part of the controversy over cultural diversity in higher education stems from the ideology of white superiority, which is pervasive and deeply rooted in American higher…

  12. Girls' Doll Play in Educational, Virtual, Ideological and Market Contexts: A Case Analysis of Controversy (United States)

    Reifel, Stuart


    The purpose of this study was to explore an example of girls' doll play in contemporary US culture, including its virtual, political, marketing, and other contextual meanings. The narrative that provoked the analysis was a brief news report about a controversial school function--a school fund-raiser fashion show featuring American Girl doll…

  13. Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions-key messages

    DEFF Research Database (Denmark)

    Gottrup, Finn; Apelqvist, Jan; Bjarnsholt, Thomas


    This article constitutes an extraction of key messages originally presented in the Document: Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions written by the European Wound Management Association (EWMA), and originally published by the Journal of Wound Care in 2013. All...

  14. Service and Emotional Support Animals on Campus: The Relevance and Controversy (United States)

    Phillips, Melinda


    Service and emotional support animals (ESA) have recently been a topic of conversation on college campuses, despite decades of controversy related to the interpretation of federal law. The distinction between an Emotional Support Animal and Service Animals, and the rights of the student regarding accommodations under FHA and ADA have been debated…

  15. Managing controversy through consultation: a qualitative study of communication and trust around MMR vaccination decisions. (United States)

    McMurray, Robert; Cheater, Francine M; Weighall, Anna; Nelson, Carolyn; Schweiger, Martin; Mukherjee, Suzanne


    Controversy over the measles, mumps, and rubella (MMR) vaccine has reduced uptake, raising concerns of a future disease epidemic. To explore parents' accounts of decision making relating to the MMR vaccine controversy, identifying uptake determinants and education needs. Qualitative interviews analysed using the 'framework' approach. Five general practices in the Leeds area, 2002-2003. Sixty-nine interviews conducted with parents of children aged between 4 and 5 years, and 12 interviews with primary care practitioners, managers and immunisation coordinators serving participating sites. Participants were interviewed one-to-one in a place of their choice. The vaccination decision is primarily a function of parental assessments of the relative acceptability and likelihood of possible outcomes. For most parents the evidence of science and medicine plays little role in the decision. Although local general practitioners and health visitors are trusted information sources, the influence of primary care providers on the vaccination decision is limited by concerns over consultation legitimacy, discussion opportunity, and perceptions of financial and political partiality. Parents and practitioners identify a need for new approaches to support decisions and learning when faced with this and similar healthcare controversies. These include new collaborative approaches to information exchange designed to transform rather than supplant existing parent knowledge as part of an ongoing learning process. The study identified new ways in which parents and practitioners need to be supported in order to increase understanding of medical science and secure more informed decisions in the face of health controversy.

  16. For a Psycholinguistic Model of Handwriting Production: Testing the Syllable-Bigram Controversy (United States)

    Kandel, Sonia; Peereman, Ronald; Grosjacques, Geraldine; Fayol, Michel


    This study examined the theoretical controversy on the impact of syllables and bigrams in handwriting production. French children and adults wrote words on a digitizer so that we could collect data on the local, online processing of handwriting production. The words differed in the position of the lowest frequency bigram. In one condition, it…

  17. Framing Controversial Identity Issues in Schools: The Case of HB2, Bathroom Equity, and Transgender Students (United States)

    Journell, Wayne


    This article explores how teachers might address controversial identity issues in their classrooms, using the 2016 North Carolina House Bill 2 that raised the issue of transgender bathroom rights to the forefront of societal discourse as an example. I analyze the issue using the three most commonly cited criteria for determining the openness of…

  18. Fair and Unfair Strategies in Public Controversies: The Case of Induced Earthquakes

    NARCIS (Netherlands)

    van Laar, Jan Albert; Krabbe, Erik C. W.; Mohammed, Dima; Lewinski, Marcin


    Contemporary theory of argumentation offers many insights about fallacies and the ways to react to them. But what if, in a public controversy, it is not a matter of occasional derailments but one party is systematically trivializing the other party’s problems or resorting to pressure in the form of

  19. Mourning, Memorials, and Religion: A Psychoanalytic Perspective on the Park51 Controversy

    Directory of Open Access Journals (Sweden)

    Nathan Carlin


    Full Text Available This article summarizes a version of the “mourning religion” thesis—derived from the work of Peter Homans and further developed and advanced by William Parsons, Diane Jonte-Pace, and Susan Henking—and then demonstrates how this thesis can shed light on the Park51 controversy. We argue that the Park51 controversy represents a case of incomplete cultural mourning of an aspect of American civil religion that manifests itself in melancholic rage by means of protests, threats to burn the Qur’an (as well as actual burnings of the Qur’an, and vandalism of mosques around the United States. We explore various losses—military, economic, and symbolic—and note that these losses remain ambiguous, therefore preventing closure and productive mourning. The fact that a permanent memorial still has not been built at Ground Zero reflects, and perhaps exacerbates, this incomplete cultural mourning. Also, the fact that Freedom Tower, the building to replace the Twin Towers, is to be 1776 feet tall reflects that the losses related to 9/11 are connected to American civil religion, as 1776 is a sacred year in American history. Setting aside the ethics and the politics related to this controversy, we attempt here to understand this controversy from a psychoanalytic perspective.

  20. Philosophical Approaches of Religious Jewish Science Teachers toward the Teaching of "Controversial" Topics in Science (United States)

    Dodick, Jeff; Dayan, Aliza; Orion, Nir


    This research examines the problems that religious Jewish science teachers in Israeli high schools have in coping with science subjects (such as geological time) which conflict with their religious beliefs. We do this by characterizing the philosophical approaches within Judaism that such teachers have adopted for dealing with such controversy.…

  1. Boundary Work and Power in the Controversy over Therapeutic Touch in Finnish Nursing Science (United States)

    Vuolanto, Pia


    The boundary work approach has been established as one of the main ways to study controversies in science. However, it has been proposed that it does not meet the power dynamics of the scientific field sufficiently. This article concentrates on the intertwining of boundary work and power. It combines the boundary work approach developed by Thomas…

  2. Honoring Controversy: Using Real-World Problems to Teach Critical Thinking in Honors Courses (United States)

    Cargas, Sarita


    In this article Sarita Cargas suggests that getting honors students used to analyzing controversies will contribute to their developing a disposition toward critical thinking. She goes on to say that the value of teaching critical-thinking skills complements the movement of many honors programs toward teaching more than just disciplinary content.…

  3. Imaging Management of Breast Density, a Controversial Risk Factor for Breast Cancer. (United States)

    Falcon, Shannon; Williams, Angela; Weinfurtner, Jared; Drukteinis, Jennifer S


    Breast density is well recognized as an independent risk factor for the development of breast cancer. However, the magnitude of risk is controversial. As the public becomes increasingly aware of breast density as a risk factor, legislation and notification laws in relation to breast density have become common throughout the United States. Awareness of breast density as a risk factor for breast cancer presents new challenges for the clinician in the approach to the management and screening of women with dense breasts. The evidence and controversy surrounding breast density as a risk factor for the development of breast cancer are discussed. Common supplemental screening modalities for breast cancer are also discussed, including tomosynthesis, ultrasonography, and magnetic resonance imaging. A management strategy for screening women with dense breasts is also presented. The American College of Radiology recognizes breast density as a controversial risk factor for breast cancer, whereas the American Congress of Obstetricians and Gynecologists recognizes breast density as a modest risk factor. Neither organization recommends the routine use of supplemental screening in women with dense breasts without considering additional patient-related risk factors. Breast density is a poorly understood and controversial risk factor for the development of breast cancer. Mammography is a screening modality proven to reduce breast cancer-related mortality rates and is the single most appropriate tool for population-based screening. Use of supplemental screening modalities should be tailored to individual risk assessment.

  4. How "Bright" is it to Use CFLs? A Look at the Controversy (United States)

    Miller, Roxanne Greitz


    Commonly referred to as CFLs, compact fluorescent light bulbs are rapidly replacing traditional incandescent light bulbs for residential use. However, controversy and even comic parody have arisen surrounding CFL use. CFLs contain small amounts of mercury, and several public forums and news agencies have been announcing that the breakage of a CFL…

  5. 'The 1901 controversy': South African cricket and the Anglo-Boer ...

    African Journals Online (AJOL)

    Of course the war dragged on but the predominantly 'Uitlander' team did go, leaving Cape Town on what was to prove a testing, if somewhat ground-breaking tour. This paper will investigate the background to this tour, the controversy it created and the development of South African cricket during this time of war. Keywords:

  6. Media Misrepresentations of a Mascot Controversy: Contested Constructions of Race and Gender (United States)

    Gerstl-Pepin, Cynthia; Liang, Guodong


    This article examines media coverage of a high school Native American mascot controversy. Discourse analysis of media documents and artifacts was utilized to explore how the issue was socially constructed for public consumption. Critical race feminism was used as a framework to examine how media discourses can oversimplify the complex interaction…

  7. Adolescents previously involved in Satanism experiencing mental health problems

    Directory of Open Access Journals (Sweden)

    H Heathcote


    Full Text Available No research has previously been done regarding the phenomenon of adolescents who have previously been involved in Satanism and who experience obstacles in their strive for mental health. Adolescents previously involved in Satanism present behavioral problems like aggressive outbursts, depression, “ psychosis” or suicide attempts, that could lead to suicide. In the phenomenonanalysis semi-structured, phenomenological interviews were performed with the respondents and their parents. The respondents were requested to write a naïve sketch about their life. After completion of the data-control, guidelines for nursing staff were set.

  8. Influence of previous participation in physical activity on its ...

    African Journals Online (AJOL)

    ... participation can influence perceptions of PA among the students. Physical activity promotion programmes should consider the role of these factors which should be emphasised from childhood. Keywords: physical activity, students, perceived benefits, perceived barriers, previous participation, sedentary lifestyle, Rwanda

  9. Choice of contraception after previous operative delivery at a family ...

    African Journals Online (AJOL)

    Choice of contraception after previous operative delivery at a family planning clinic in Northern Nigeria. Amina Mohammed‑Durosinlorun, Joel Adze, Stephen Bature, Caleb Mohammed, Matthew Taingson, Amina Abubakar, Austin Ojabo, Lydia Airede ...

  10. Payload specialist Reinhard Furrer show evidence of previous blood sampling (United States)


    Payload specialist Reinhard Furrer shows evidence of previous blood sampling while Wubbo J. Ockels, Dutch payload specialist (only partially visible), extends his right arm after a sample has been taken. Both men show bruises on their arms.

  11. Delivery outcomes at term after one previous cesarean section. (United States)

    Yamani-Zamzami, Tarik Y


    To determine the maternal and perinatal outcomes at term in women with one previous cesarean delivery and with no history of vaginal birth. This is a case-control study conducted at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, between January 1, 1999 and December 31, 2002. One hundred sixty-two women with one previous cesarean delivery and with no previous vaginal birth were compared with 324 control women. The cesarean section rate was higher in the study group 40 (24.7%) versus 23 (7.1%) in the control group and was statistically significant (phistory of vaginal delivery are considered less favorable, the vaginal birth after cesarean section success rate may be even lower if the indication for previous primary cesarean delivery was failure to progress, and may be associated with increased risk of uterine rupture. Further study is required to confirm our findings.

  12. Emanuel Edward Klein--the father of British microbiology and the case of the animal vivisection controversy of 1875. (United States)

    Atalić, Bruno; Fatović-Ferencić, Stella


    The new Appendix A of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, which gives guidelines for accommodation and care of animals and was approved on June 15, 2006, was the main reason the authors decided to investigate the origins of the regulations of animal experiments. Although one might assume that the regulation had its origin in the United Nations conventions, the truth is that its origins are a hundred years old. The authors present a case of the nineteenth-century vivisection controversy brought about by the publication of the Handbook for the Physiological Laboratory in 1873, in which John Burdon-Sanderson, Emanuel Edward Klein, Michael Foster, and Thomas Lauder Brunton described a series of vivisection experiments they performed on animals for research purposes. It was the first case of vivisection to be examined, processed, and condemned for inhuman behavior toward animals before an official body, leading to enactment of the Cruelty to Animals Act in 1876. The case reveals a specific ethos of science in the second half of the nineteenth century, which was characterized by a deep commitment of scientists to the scientific enterprise and their strong belief that science could solve social problems, combined with an overt insensitivity to the suffering of experimental animals. The central figure in the case was Emanuel Edward Klein, a disciple of the Central European medical tradition (Vienna Medical School) and a direct follower of the experimental school of Brücke, Stricker, Magendie, and Bernard. Because of his undisguised attitudes and opinions on the use of vivisection, Klein became a paradigm of the new scientific identity, strongly influencing the stereotypic image of a scientist, and polarizing the public opinion on vivisection in England in the nineteenth century and for some considerable time afterward.

  13. [Influence of previous abdominopelvic surgery on gynecological laparoscopic operation]. (United States)

    Jin, Haoran; Shi, Wei; Zhou, Yingfang; Wu, Beisheng; Peng, Chao


    To investigate the influence of previous abdominopelvic surgery on gynecological laparoscopic operation. A retrospective analysis of 3 283 cases of gynecological diseases by laparoscopic operation patients in Peking University First Hospital from 2007 January to 2012 December, among them, 719 (21.90%) patients with previous abdominopelvic surgery history (study Group), 2 564 (78.10%)patients have no history of abdominopelvic surgery (control group). Study group 719 patients, previous operation times: one time in 525 cases, 194 cases were multiple; previous operation: 185 cases of gynecological surgery, 305 cases of obstetric surgery, 108 cases of general surgery, and 121 complex surgery (include at least two kinds of surgery); previous operative approach: 650 cases laparotomy and 69 cases laparoscopy. Compared two groups of patients with abdominopelvic adhesion and the gynecologic laparoscopic operation situation, analyzed the influence of previous abdominopelvic surgery on abdominopelvic adhesion on and gynecological laparoscopic operation. The incidence of abdominopelvic adhesion in the patients with previous abdominopelvic surgery was 51.2% (368/719), which was significantly higher than that of 8.2% (211/2 564)in patients without previous abdominopelvic surgery (P surgery (23.1%, 166/719) was significantly higher than that in the control group (3.3% , 85/2 564;P laparotomy was 0.6% (4/719) significantly more than the control groups (0.1%, 2/2 564; P = 0.023). Compared with other groups, patients with gynecological or complex surgery or multiple operation history presented more severe abdominopelvic adhesion both in the score and degree (P laparotomy showed no statistical difference between the two groups (P > 0.05). The laparoscopic operation could be carried out successfully and safely in patients with a history of various abdominopelvic operations, but the conversion rate increases, for patients with a history of multiple operation because of pelvic adhesion

  14. Reappraisal of soil C storage processes. The controversy on structural diversity of humic substances as biogeochemical driver for soil C fluxes (United States)

    Almendros, Gonzalo; Gonzalez-Vila, Francisco J.; Gonzalez-Perez, Jose Antonio; Knicker, Heike


    The functional relationships between the macromolecular structure of the humic substances (HS) and a series of biogeochemical processes related with the C sequestration performance in soils have been recently questioned. In this communication we collect recent data from a wide array of different ecosystems where the C storage in soils has been studied and explained as a possible cause-to-effect relationship or has been found significantly correlated (multivariate statistical models) with a series of structural characteristics of humic materials. The study of humic materials has methodological analytical limitations that are derived from its complex, chaotic and not completely understood structure, that reflects its manifold precursors as well as the local impact of environmental/depositional factors. In this work we attempt to design an exploratory, multiomic approach based on the information provided by the molecular characterization of the soil organic matter (SOM). Massive data harvesting was carried out of statistical variables, to infer biogeochemical proxies (spectroscopic, chromatographic, mass spectrometric quantitative descriptors). The experimental data were acquired from advanced instrumental methodologies, viz, analytical pyrolysis, compound-specific stable isotope analysis (CSIA), derivative infrared (FTIR) spectroscopy, solid-state C-13 and N-15 nuclear magnetic resonance (NMR) and mass spectrometry (MS) data after direct injection (thermoevaporation), previous pyrolysis, or ion averaging of specific m/z ranges from classical GC/MS chromatograms. In the transversal exploratory analysis of the multianalytical information, the data were coded for on-line processing in a stage in which there is no need for interpretation, in molecular or structural terms, of the quantitative data consisting of e.g., peak intensities, signal areas, chromatographic (GC) total abundances, etc. A series of forecasting chemometric approaches (aiming to express SOM

  15. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh


    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  16. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh


    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  17. Effectiveness of disinfection with alcohol 70% (w/v) of contaminated surfaces not previously cleaned


    Graziano, Maurício Uchikawa; Graziano, Kazuko Uchikawa; Pinto, Flávia Morais Gomes; Bruna, Camila Quartim de Moraes; Souza, Rafael Queiroz de; Lascala, Cesar Angelo


    OBJECTIVE: To evaluate the disinfectant effectiveness of alcohol 70% (w/v) using friction, without previous cleaning, on work surfaces, as a concurrent disinfecting procedure in Health Services. METHOD: An experimental, randomized and single-blinded laboratory study was undertaken. The samples were enamelled surfaces, intentionally contaminated with Serratia marcescens microorganisms ATCC 14756 106 CFU/mL with 10% of human saliva added, and were submitted to the procedure of disinfection W...

  18. Animal rights and animal experimentation. Implications for physicians. (United States)

    Gelpi, A. P.


    Practicing physicians are just becoming aware of the animal rights movement, which during the 1980s spawned numerous acts of violence against research facilities throughout the United States. The animal rightists are challenging physicians to show moral justification for the human exploitation of nature and the world of subhuman species. They have aroused public interest in animal welfare, sparked protective legislation for experimental animals, and indirectly encouraged the creation of committees to oversee the conduct of animal experimentation and the conditions of animal confinement. This controversy has necessitated a closer look at the questions of animal experimentation and animal rights against the backdrop of human experimentation and human rights. Physicians and specialists in animal care seek to alleviate suffering and anxiety, and, as moderates, they may be able to bring both sides of the animal rights controversy together in a spirit of mutual tolerance and in the common cause of promoting both human and animal welfare. PMID:1949772

  19. Current controversies in prenatal diagnosis 1: NIPT for chromosome abnormalities should be offered to women with low a priori risk

    NARCIS (Netherlands)

    van Lith, Jan M. M.; Faas, Brigitte H. W.; Bianchi, Diana W.


    In its successful annual cycle of controversies and debates, the International Society of Prenatal Diagnosis and Therapy once again addressed non-invasive prenatal testing (NIPT) by following up on the 2013 controversy, Should non-invasive DNA testing be the standard screening test for Down syndrome

  20. Current controversies in prenatal diagnosis 1: NIPT for chromosome abnormalities should be offered to women with low a priori risk

    NARCIS (Netherlands)

    Lith, J.M. van; Faas, B.H.W.; Bianchi, D.W.


    In its successful annual cycle of controversies and debates, the International Society of Prenatal Diagnosis and Therapy once again addressed non-invasive prenatal testing (NIPT) by following up on the 2013 controversy, 'Should non-invasive DNA testing be the standard screening test for Down

  1. The Effect of Falsely Balanced Reporting of the Autism-Vaccine Controversy on Vaccine Safety Perceptions and Behavioral Intentions (United States)

    Dixon, Graham; Clarke, Christopher


    Controversy surrounding an autism-vaccine link has elicited considerable news media attention. Despite being widely discredited, research suggests that journalists report this controversy by presenting claims both for and against a link in a relatively "balanced" fashion. To investigate how this reporting style influences judgments of vaccine…

  2. Diagnostic Issues and Controversies in DSM-5: Return of the False Positives Problem. (United States)

    Wakefield, Jerome C


    The fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was the most controversial in the manual's history. This review selectively surveys some of the most important changes in DSM-5, including structural/organizational changes, modifications of diagnostic criteria, and newly introduced categories. It analyzes why these changes led to such heated controversies, which included objections to the revision's process, its goals, and the content of altered criteria and new categories. The central focus is on disputes concerning the false positives problem of setting a valid boundary between disorder and normal variation. Finally, this review highlights key problems and issues that currently remain unresolved and need to be addressed in the future, including systematically identifying false positive weaknesses in criteria, distinguishing risk from disorder, including context in diagnostic criteria, clarifying how to handle fuzzy boundaries, and improving the guidelines for "other specified" diagnosis.

  3. What’s in a name? Problems, facts and controversies regarding neurological eponyms

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive


    Full Text Available ABSTRACT The use of eponyms in neurology remains controversial, and important questions have been raised about their appropriateness. Different approaches have been taken, with some eponyms being excluded, others replaced, and new ones being created. An example is Hallervorden-Spatz syndrome, which has been replaced by neurodegeneration with brain iron accuulatium (NBIA. Amiothoplic lateral sclerosys (ALS, for which the eponym is Charcot’s disease, has been replaced in the USA by Lou Gehrig’s disease. Guillain-Barré syndrome (GBS is an eponym that is still the subject of controversy, and various different names are associated with it. Finally,restless legs syndrome (RLS, which was for years known as Ekbom’s syndrome, has been rechristened as RLS/Willis-Ekbom syndrome.

  4. How did the fracking controversy emerge in the period 2010-2012? (United States)

    Mazur, Allan


    In 2010-2012, the controversy over fracking grew rapidly, first in the United States, and then internationally. An important step was the anti-fracking documentary film Gasland. With help from celebrity sources, the film was produced and won a prize at the Sundance Film Festival by early 2010 and had an Oscar nomination by early 2011, in the meantime popularizing potent images of hazard including tainted aquifers and ignitable water running from kitchen faucets. During this period, major US news organizations paid little attention to the issue. The offshore Deepwater Horizon disaster of April 2010 spurred The New York Times to prolific reporting on potential risks of the new onshore technique for extracting shale gas. With flagship news coverage, the controversy had by 2012 gained wide media attention that evoked public concern and opposition, spreading from the United States to other nations. © The Author(s) 2014.

  5. Sexual orientation and gender identity: review of concepts, controversies and their relation to psychopathology classification systems. (United States)

    Moleiro, Carla; Pinto, Nuno


    Numerous controversies and debates have taken place throughout the history of psychopathology (and its main classification systems) with regards to sexual orientation and gender identity. These are still reflected on present reformulations of gender dysphoria in both the Diagnostic and Statistical Manual and the International Classification of Diseases, and in more or less subtle micro-aggressions experienced by lesbian, gay, bisexual and trans patients in mental health care. The present paper critically reviews this history and current controversies. It reveals that this deeply complex field contributes (i) to the reflection on the very concept of mental illness; (ii) to the focus on subjective distress and person-centered experience of psychopathology; and (iii) to the recognition of stigma and discrimination as significant intervening variables. Finally, it argues that sexual orientation and gender identity have been viewed, in the history of the field of psychopathology, between two poles: gender transgression and gender variance/fluidity.

  6. Sexual Orientation and Gender Identity: Review of concepts, controversies and their relation to psychopathology classification systems

    Directory of Open Access Journals (Sweden)

    Carla eMoleiro


    Full Text Available Numerous controversies and debates have taken place throughout the history of psychopathology (and its main classification systems with regards to sexual orientation and gender identity. These are still reflected on present reformulations of gender dysphoria in both DSM and ICD, and in more or less subtle micro-aggressions experienced by lesbian, gay, bisexual and trans patients in mental health care. The present paper critically reviews this history and current controversies. It reveals that this deeply complex field contributes (i to the reflection on the very concept of mental illness; (ii to the focus on subjective distress and person-centered experience of psychopathology; and (iii to the recognition of stigma and discrimination as significant intervening variables. Finally, it argues that sexual orientation and gender identity have been viewed, in the history of the field of psychopathology, between two poles: gender transgression and gender variance/fluidity.

  7. [3rd and 4th generation estroprogestatives French controversy: What effect on women's behavior?]. (United States)

    Torres, Luis; Frapard, Christian; Daumas, Aurélie; Guibert, Nicolas; Lagouanelle-Simeoni, Marie-Claude; Rakoto, Jean-Claude; Villani, Patrick; Sambuc, Roland


    The primary objective of this study was to determine the reasons given by women who have changed or suspended their contraceptive method in 2013. What influence had the 3rd and 4th generation estroprogestatives (EP) French controversy and advices from doctors? Did they notice any consequences of the controversy on their lifestyle? Did they feel an impact on their behavior to health professionals? A study was conducted on women of childbearing age. Data collection took place between November 4 and December 16, 2013. The included subjects were between 18 and 55 years old females. Subjects were surveyed through an anonymous self-administered questionnaire distributed through pharmacies. The protocol called for the construction of clusters of subjects by having heard about, or not, of the controversy. Patients reporting having heard about the controversy have formed the "exposed" group while the others have formed the "unexposed" group. We compared two parameters between these two groups: the rate of subjects who reported having modified or suspended their contraceptive method in 2013 on one hand, and the rate of subjects who reported having made a change in their contraceptive method without or against advices from a doctor on the other hand. The sample included 988 subjects. The average age was 34 years. The level of exposure to media debates was 86.5%. Of the respondents, 19.8% were under 3rd or 4th generation EP in 2012, thus directly involved in the discussions and affected by health recommendations. Of the patients, 38.5% reported having changed their contraception in 2013. In these women, when they confirmed having heard about the controversy, 40.1% of them claimed to have conducted this process without or against advices from a doctor. This number dropped to 18.2% for those who had not heard of it. Media coverage of the 3rd and 4th generation EP vascular risk was not mentioned more by patients who suspended all medical contraceptive method than it was by

  8. The Use and Abuse of ‘Universal Values' in the Danish Cartoon Controversy

    DEFF Research Database (Denmark)

    Rostbøll, Christian F.


    In the course of the Danish cartoon controversy, appeals to universal liberal values were often made in ways that marginalized Muslims. An analysis of the controversy reveals that referring to "universal values" can be exclusionary when dominant actors fail to distinguish their own culture......'s embodiment of these values from the more abstract ideas. The article suggests that the solution to this problem is not to discard liberal principles but rather to see them in a more fallibilistic and deliberative democratic way. This means that we should move from focusing on citizens merely as subjects...... of law and right holders to see them as co-authors of shared legal and moral norms. A main shortcoming of the way in which dominant actors in Denmark responded to the cartoons was exactly that they failed to see the Muslim minority as capable of participating in interpreting and giving shared norms...

  9. Human Rights Education: A Pedagogical and Didactic (Teaching Strategy Focused in a Controversial Perspective

    Directory of Open Access Journals (Sweden)

    Abraham Magendzo-Kolstrein


    Full Text Available The purpose of this article, which can be envision as an essay, is to present a pedagogical-didactic strategy for human rights education focusing on the controversy. Advancements and setbacks faced by human rights education in Latin America are exposed in order to support this strategy. Therefore, it indicates that education has denied the conflict and explains the need for its inclusion under the idea of ‘controversial issue’. Additionally, the existence of conflicts in the interpretation, violation and/or respect for human rights is pointed out. The principal tensions that cross human rights are displayed. Based on the above, the need to support the existence of a human rights education focusing on the conflict and central components of its teaching strategy are described, and it ends by referring to its didactic approach and the role which should be assumed by faculty when teaching human rights including the conflict.

  10. 1 Corinthians 14:26-40 in the Theological Rhetoric of the Admonition Controversy

    Directory of Open Access Journals (Sweden)

    Graves Daniel F.


    Full Text Available This paper discusses competing notions of the concept of ‘order’ in the Admonition Controversy with respect to the interpretation of the decorum of 1 Corinthians 14:26-30, a text principally concerned with order in worship. As the controversy ensued the understanding of ‘order’ broadened to include church discipline and polity, both Puritan and Conformist alike constructed their polemic with a rhetorical appeal to the Pauline text in question-interpretations at odds with each other. Furthermore, both sides understood their interpretation as standing faithfully in the tradition of Calvin. This paper follows the appeals to 1 Corinthians 14:26-40 by Advanced Protestants and Conformists from its use in the treatise ‘Of Ceremonies’ found in the Book of Common Prayer, through the Admonition to the Parliament, the responses of John Whitgift and Thomas Cartwright, and finally Richard Hooker’s Preface to the Lawes of Ecclesiastical Politie.

  11. [The controversy between Grotius, Hobbes and Spinoza on the jus circa sacra texts, pretexts, contexts and circomstances]. (United States)

    Lærke, Mogens


    In this contribution, I sketch out a methodological framework for the study of controversies in the history of philosophy. It is built around four basic components: texts, contexts, pretexts and circumstances. I show how, once these four elements have been identified and systematically distinguished and distributed, a controversy has been localized and circumscribed. I show, moreover, how controversies are formally linked to each other through the migration of texts from one context to another. Next, I take as an example the controversy on the jus circa sacra, or "right of holy matters," a key controversy in the political philosophy of the early modern period, focusing in particular on the work by Grotius, Hobbes and Spinoza.

  12. Sustainable development and wordwide con-troversial issues regarding the auction of pollution right


    Ph. D. Mariana Iovitu


    The present study investigates one of the most up-to-date scientific and pragmatic problems faced by the evolution of the human society, by the European Union and by the future of this planet: pollution as externality of the economic growth.The inclusion of the sustainable development objectives in the framework of the ambitious goals of the Lisbon Strategy is launching once again several controversies concerning the analysis of the global auction process of pollution right. Linked to the co...

  13. Controversy still simmers over plan to build plasma-fractionation plant in Nova Scotia.


    Robb, N


    Controversy still simmers over a plan by the Canadian Red Cross Society and a US biopharmaceutical manufacturer to build a plasma-fractionation plant near Halifax. The unilateral decision to go ahead with the plant was taken as the Krever inquiry into Canada's blood-supply system was holding public hearings across the country. A panel created to evaluate the proposal has supported the fractionation plant, but made additional recommendations concerning product pricing, research and development...

  14. Controversial Issues Relevant to Sustainable Urbanism: A Review of Global Urban Tendencies


    Abbas M. Hassan; Hyowon Lee


    Academic urban debates shrouded with paradox render the transition to sustainable urban development (SUD) vague and unclear. The premise of this study is that the elimination of the controversial points included in each issue, in addition to reconciliation among these issues, may propel SUD. Therefore, this study dialectically discusses five urban issues: urban form, urban growth, transportation, urban vegetation, and governance (social participation). These issues were chosen among ten issue...

  15. Medical students and controversial ethical issues: results from the multicenter study SBRAME. (United States)

    Lucchetti, Giancarlo; de Oliveira, Leandro Romani; Leite, José Roberto; Lucchetti, Alessandra Lamas Granero


    Medical students(MS) will face ethical issues throughout their lives as doctors. The present study aims to investigate medical students' opinions on controversial ethical issues and factors associated with these opinions. SBRAME (Spirituality and Brazilian Medical Education) is a multicenter study involving 12 Brazilian medical schools with 5950 MS. Participants completed a questionnaire that collected information on socio-demographic data, medical schools characteristics, religious beliefs and opinions on controversial ethical issues. Of all MS, 3630 participated in the survey (61.0%). The sample was 53.8% women and the mean age was 22.5 years. In general, most MS have no objections to prescription of birth control (90.8%), adult stem cell use (87.5%), embryonic stem cell use (82.0%) and abortion for genetic reasons (51.2%). Approximately half of students have no objections to human cloning (47.3%), 45.7% to withdrawal of artificial life support, 41.4% to euthanasia and 23.3% to abortion for failed contraception. Socio-demographic data such as age, gender and income had little influence on MS opinions. On the other hand, medical schools characteristics (number of medical students in the university, year of medical school foundation, location of the university and type of university) and religious aspects (religious affiliation, religious attendance, non-organizational religiousness and intrinsic religiousness) were highly correlated with their opinions. In general, MS with more supportive opinions on controversial ethical issues were less religious and from non-traditional (newer), urban, public and bigger universities. The current study reveals MS have different opinions regarding controversial ethical issues. Noteworthy, these opinions seem to be shaped more by university characteristics and religious beliefs than socio-demographic data.



    Ramona Mariana Calinica; Viorica Ioan


    Globalization is a complex phenomenon, often debated in the literature, around which numerous controversies have formed, in time. The purpose of this article is the analysis of the globalization process in its essential aspects. The study begins by defining the concept and continues with an analysis of for and against opinions on globalization and this phenomenon’s effects, both positive as well as negative.

  17. The Tax Controversy or, Should We Forsake Indirect Taxation? A Survey of the Literature


    Micheletto Luca


    We revise the more recent advances in the literature about the so called "direct versus indirect controversy". In particular, we show how the result of "uniform commodity tax under non-linear income taxation" by Atkinson and Stiglitz (1976) has been amended in some contributions that recovers a role for in direct taxation as an instrument of optimal tax policy even in the case where agents' preferences are weakly separable between leisure and other goods.

  18. The social construction of risk and the controversial Brazilian Nuclear Program: among scientific, political and public

    International Nuclear Information System (INIS)

    Camelo, Ana Paula


    This research aims to investigate the Brazilian Nuclear Program (PNB) stating as reference the Fukushima nuclear accident. Its main purpose is to analyze how the Japanese accident impacted the PNB. Therefore, the program will be analyzed within 10-years (2004-2014) in order to answer this question. The discussion launched in this thesis is based on the framework of the Social Studies of Science and Technology, which enables the understanding of socio-technical controversies beyond the social or technological determinism. Through the discussion of the concepts of framing, socio-technical imaginary, risk and governance of science and technology, the research shows how the controversy in focus has resulted in the opportunity to consider not only economic, technological, environmental issues about nuclear energy, but also its political dimensions and challenges. Among these challenges, and from very different perspectives, arise questions about the role nuclear energy plays in the Brazilian context, the future of the program and the decision making process on these issues. Despite the central purpose of this study is essentially on risks, PNB and on the Brazilian context, it should be pointed that it is impossible to consider it in isolation of what is happening internationally (considering interests, tensions, relations between actors, etc.) The research thereby identifies key implications of Fukushima in the international context, but focuses on the disputes regarding possible review of the PNB. It also highlights how the socio-technical controversies, such as the nuclear energy, demand or impose a discussion on the governance of science and technology, risk and on the engagement of different sectors and actors in decision-making on issues, that are at the same time about energy, technology and nationality relevance. All this reflection is made from multi-sited analysis, which allowed following the controversy surrounding nuclear energy, reheated by the Fukushima

  19. The Right of Self-Determination: Its Emergence, Development, and Controversy


    Manan, Munafrizal


    This paper discusses the right of self-determinationfrom International law and International human rights law perspective. It traces the emergence and development of self-determination from political principle to human right. It also explores the controversy of the right of self-determination. There have been different and even contradictory interpretations of the right of self-determination. Besides, there is no consensus on the mechanism to apply the right of self-determination. Both Int...

  20. Internet governance as 'ideology in practice' – India's 'Free Basics' controversy


    Gurumurthy (Anita); Chami (Nandini)


    The paper examines the recent Free Basics controversy in India, which triggered a national level policy debate on the appropriate regulatory response to differential pricing of data services, employing the theoretical framework of 'ideology in practice'. Unpacking 'openness' in design, 'inclusion' in provisioning and 'empowerment' in use as contested concepts in the policy process, the paper demonstrates a paradoxical conflation of oppositional interpretations of access. Tracing the material-...

  1. Combined modality therapy in pancreatic adenocarcinoma: review and updates on a controversial issue. (United States)

    Cavalcante, Ludimila; Kelsen, David P; Yu, Kenneth H


    Due to its extremely high mortality rates, strong efforts continue to be made to develop new therapies in the treatment of pancreatic adenocarcinoma. The use of combined modality chemoradiotherapy for the treatment of pancreatic adenocarcinoma remains an approach with both promise and controversy. This article reviews the conflicting data with regards to role of combined modality therapy in pancreatic adenocarcinoma and provides an update on current studies in the field.

  2. U.S. Military Aviation Mishaps In Japan and Okinawan Political Controversy (United States)


    occupation” with the intent to “occupy briefly, transform local politics in Wilsonian fashion , and then depart.”8 The years immediately following...existence for American forces in Japan. The U.S. heavily depended on its Japanese bases to support demanding wars in Korea and Vietnam. Additionally, payments.22 In Okinawa, local media outlets and newspapers have remained anti-base throughout the years, politicizing controversial

  3. Removing Mill Weirs in France: The Structure and Dynamics of an Environmental Controversy

    Directory of Open Access Journals (Sweden)

    Regis Barraud


    Full Text Available In France, as in many other parts of Europe and North America, the vast increase in the number of dam removals in order to restore ecological continuity has led to a large number of local conflicts, resulting in a significant ecological controversy. Most of these hydraulic works were connected to former water mills. This article will suggest new analytical methods to help understand and interpret this controversy through the use of two complementary approaches. The first is based on a geohistorical approach. It allows us to identify the development of the meanings and values associated with mill weirs and also to trace the development, since the 19th century, of state involvement in dealing with their ecological impact. Our second method, based on political ecology, attempts to decipher the current state of the controversy. Taking this as our objective we have undertaken a qualitative analysis of the discourse produced on a national level and also of the network of actors who make up the oppositional base to dam removal. The affective and emotional dimensions of the controversy, and also the attachment to local places, both of which are often crucial in the expression of opposition on the local scale, can be identified in the discourse. Yet, the discourse we have analysed reveals argumentative poles which translate both the opposition based on rational arguments and also an alternative vision of the development of rivers (heritage status, green and local power production. The oppositional argument which has been developed notably includes a discussion of the knowledge and scientific expertise upon which the process of dam removal is based. It also includes a critique of local consultation and decision-making methods.

  4. 2 CFR 225.45 - Relationship to previous issuance. (United States)


    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuance. 225.45 Section 225.45 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR STATE, LOCAL, AND INDIAN TRIBAL GOVERNMENTS (OMB CIRCULAR A-87) § 225.45 Relationship to...

  5. Cryptococcal meningitis in a previously healthy child | Chimowa ...

    African Journals Online (AJOL)

    An 8-year-old previously healthy female presented with a 3 weeks history of headache, neck stiffness, deafness, fever and vomiting and was diagnosed with cryptococcal meningitis. She had documented hearing loss and was referred to tertiary-level care after treatment with fluconazole did not improve her neurological ...

  6. Rapid fish stock depletion in previously unexploited seamounts: the ...

    African Journals Online (AJOL)

    Rapid fish stock depletion in previously unexploited seamounts: the case of Beryx splendens from the Sierra Leone Rise (Gulf of Guinea) ... A spectral analysis and red-noise spectra procedure (REDFIT) algorithm was used to identify the red-noise spectrum from the gaps in the observed time-series of catch per unit effort by ...

  7. Obstructive pulmonary disease in patients with previous tuberculosis ...

    African Journals Online (AJOL)

    Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort. B.W. Allwood, R Gillespie, M Galperin-Aizenberg, M Bateman, H Olckers, L Taborda-Barata, G.L. Calligaro, Q Said-Hartley, R van Zyl-Smit, C.B. Cooper, E van Rikxoort, J Goldin, N Beyers, E.D. Bateman ...

  8. Balance and bilateral skills of selected previously disadvantaged ...

    African Journals Online (AJOL)

    Balance and bilateral skills of selected previously disadvantaged children aged 9 to 12 years. Eileen K Africa, Karel J Van Deventer. Abstract. The main aim of the study was to design an appropriate motor skills development programme that could be implemented in any primary school to improve the fundamental motor ...

  9. Outcome Of Pregnancy Following A Previous Lower Segment ...

    African Journals Online (AJOL)

    Background: A previous ceasarean section is an important variable that influences patient management in subsequent pregnancies. A trial of vaginal delivery in such patients is a feasible alternative to a secondary section, thus aiding to reduce the ceasarean section rate and its associated co-morbidities. Objective: To ...

  10. Suburethral sling procedures after previous surgery for urinary ...

    African Journals Online (AJOL)

    Objective. To compare the outcome of suburethral sling procedures (tension-free vaginal tape (TVT), obturator tape (Ob-tape)) for stress urinary incontinence (SUI) in women with previous surgery for SUI or pelvic organ prolapse (POP). Methods. A comparative, descriptive, retrospective study was done using information ...

  11. 5 CFR 532.405 - Use of highest previous rate. (United States)


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Use of highest previous rate. 532.405 Section 532.405 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... rate may be based upon a rate of pay received during a temporary promotion, so long as the temporary...

  12. 24 CFR 1710.552 - Previously accepted state filings. (United States)


    ... of Substantially Equivalent State Law § 1710.552 Previously accepted state filings. (a) Materials... and contracts or agreements contain notice of purchaser's revocation rights. In addition see § 1715.15..., unless the developer is obligated to do so in the contract. (b) If any such filing becomes inactive or...

  13. 5 CFR 9701.352 - Use of highest previous rate. (United States)


    ... HUMAN RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Pay Administration § 9701.352 Use of... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Use of highest previous rate. 9701.352 Section 9701.352 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT...

  14. Bilateral orbital infarction and retinal detachment in a previously ...

    African Journals Online (AJOL)

    In this report, we present a case of an 11‑year‑old previously undiagnosed sickle cell disease Nigerian girl with severe acute bilateral orbital infarction and retinal detachment to highlight that hemoglobinopathy induced orbital infarction should be considered in African children with acute onset proptosis with or without ...

  15. Response to health insurance by previously uninsured rural children. (United States)

    Tilford, J M; Robbins, J M; Shema, S J; Farmer, F L


    To examine the healthcare utilization and costs of previously uninsured rural children. Four years of claims data from a school-based health insurance program located in the Mississippi Delta. All children who were not Medicaid-eligible or were uninsured, were eligible for limited benefits under the program. The 1987 National Medical Expenditure Survey (NMES) was used to compare utilization of services. The study represents a natural experiment in the provision of insurance benefits to a previously uninsured population. Premiums for the claims cost were set with little or no information on expected use of services. Claims from the insurer were used to form a panel data set. Mixed model logistic and linear regressions were estimated to determine the response to insurance for several categories of health services. The use of services increased over time and approached the level of utilization in the NMES. Conditional medical expenditures also increased over time. Actuarial estimates of claims cost greatly exceeded actual claims cost. The provision of a limited medical, dental, and optical benefit package cost approximately $20-$24 per member per month in claims paid. An important uncertainty in providing health insurance to previously uninsured populations is whether a pent-up demand exists for health services. Evidence of a pent-up demand for medical services was not supported in this study of rural school-age children. States considering partnerships with private insurers to implement the State Children's Health Insurance Program could lower premium costs by assembling basic data on previously uninsured children.

  16. The effect of previous traumatic injury on homicide risk. (United States)

    Griffin, Russell L; Davis, Gregory G; Levitan, Emily B; MacLennan, Paul A; Redden, David T; McGwin, Gerald


    Research has reported that a strong risk factor for traumatic injury is having a previous injury (i.e., recidivism). To date, the only study examining the relationship between recidivism and homicide reported strong associations, but was limited by possible selection bias. The current matched case-control study utilized coroner's data from 2004 to 2008. Subjects were linked to trauma registry data to determine whether the person had a previous traumatic injury. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between homicide and recidivism. Homicide risk was increased for those having a previous traumatic injury (OR 1.81, 95% CI 1.09-2.99) or a previous intentional injury (OR 2.53, 95% CI 1.24-5.17). These results suggest an association between homicide and injury recidivism, and that trauma centers may be an effective setting for screening individuals for secondary prevention efforts of homicide through violence prevention programs. © 2014 American Academy of Forensic Sciences.

  17. Control of feed intake as affected by previous treatment | Pienaar ...

    African Journals Online (AJOL)

    An experiment was conducted with eighteen rumen cannulated sheep fed on a chopped lucerne diet. Previous level of intake significantly influenced the level at which sheep initially established voluntary feed intake. This difference had disappeared after three weeks on an ad lib. intake. Perturbation analysis of the results ...

  18. "Battered Women" and Previous Victimization: Is the Question Relevant? (United States)

    Gudim, Laurie, Comp.; And Others

    This report discusses battered women and the role of their previous victimization. After a literature review on family violence in general, these topics are discussed: (1) family violence and the patriarchy; (2) the historical background of family violence; (3) intergenerational cycle of violence; and (4) psychological literature's four ways…

  19. Choice of contraception after previous operative delivery at a family ...

    African Journals Online (AJOL)

    Age, education, religion, parity, prior contraception, and interval from the last delivery were significantly associated with the current choice of contraception (P 0.05). Overall, when comparing the pattern among those with a previous operative delivery and those without, ...

  20. Process cells dismantling of EUREX pant: previous activities

    International Nuclear Information System (INIS)

    Gili, M.


    In the '98-'99 period some process cells of the EUREX pant will be dismantled, in order to place there the liquid wastes conditioning plant 'CORA'. This report resumes the previous activities (plant rinsing campaigns and inactive Cell 014 dismantling), run in the past three years and the drawn experience [it

  1. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    The aim of this study was to identify influences on the job satisfaction of previously disadvantaged school principals in North-West Province. Evans's theory of job satisfaction, morale and motivation was useful as a conceptual framework. A mixedmethods explanatory research design was important in discovering issues with ...

  2. Previous utilization of service does not improve timely booking in ...

    African Journals Online (AJOL)

    Previous utilization of service does not improve timely booking in antenatal care: Cross sectional study on timing of antenatal care booking at public health facilities in ... Methods: A cross sectional study was conducted to collect data from 630 pregnant women who were attending antenatal care service at 10 governmental ...

  3. Research Note Effects of previous cultivation on regeneration of ...

    African Journals Online (AJOL)

    We investigated the effects of previous cultivation on regeneration potential under miombo woodlands in a resettlement area, a spatial product of Zimbabwe's land reforms. We predicted that cultivation would affect population structure, regeneration, recruitment and potential grazing capacity of rangelands. Plant attributes ...

  4. Mondor's Disease of the Breast in a Nigerian Woman Previously ...

    African Journals Online (AJOL)


    Sep 14, 2017 ... Case Report. How to cite this article: Olarinoye-Akorede SA, Silas BT. Mondor's disease of the breast in a Nigerian woman previously treated for invasive ductal carcinoma in the ... and the new creations are licensed under the identical terms. For reprints .... malignancy. Financial support and sponsorship.

  5. 44 CFR 402.5 - Forwarding commodities previously shipped. (United States)


    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Forwarding commodities... commodities previously shipped. Order T-1 applies to transportation on or discharge from ships documented... ship or aircraft, before the issuance of Order T-1, had transported restricted commodities manifested...

  6. Factors Affecting the Participation of Social Studies Teacher Candidates in Discussions on Controversial Issues

    Directory of Open Access Journals (Sweden)

    A. Figen ERSOY


    Full Text Available Social studies teachers employ discussions about controversial issues in their classrooms as an effective instructional tool in order to improve citizenship education. Therefore, teaching about controversial issues in preservice social studies programs is important for improving pre-service teachers’ understanding of their own abilities to teach about citizenship issues and their skills to teach about controversial issues in their classrooms as well. Preservice teachers ought to be encouraged to participate more in classroom discussions about controversial issues. Therefore, this study aim to understand and explain factors that affect social studies teacher candidates’ participation in classroom discussions about controversial issues and suggest how this process might be more efficient and effective in Turkey. 1957 pre-service social studies teachers from 12 different universities in Turkey participated in this study. A questionaire was used to collect data for this research. The questionaire included likert type 16 items regarding students’ personal information and factors that affect the level of participation in classroom discussions about controversial issues and one open-ended question regarding implications on how discussions can be improved in a way that help the discussions more effective and efficient. Chi-Square, frequency, and percentange tests were used to analyze the quantitative data. Inductive content analysis method was employed to analyze and code the qualitative data. The findings of the study showed that while 92.2 % pre-service social studies teachers stated that they participate in the dicussions on controversial issues when they only find it interested, 79.4 % participant pointed out that they do not participate in the discussions, if they believe they do not have enough knowledge about the topic of the dicussion. In addition, 47.5% of the participants stated that they do not want to participate in the discussions

  7. Socio-Scientific Controversial Issues in 1st Cycle of Basic Education

    Directory of Open Access Journals (Sweden)

    Fábio Ribeiro


    Full Text Available Assuming the importance of science education, from early years, aiming to educate citizens capable of thinking critically and act in scientific and technological contexts, a study was carried out in order to develop learning situations focused on controversial socio-scientific issues to promote students’ argumentation skills and scientific knowledge building / mobilization. The study was based on a qualitative methodology, following an action research plan. It was conducted with a class of 3th grade, having been addressed controversial socio-scientific issues, framed in science curriculum topics, using strategies of debate, role-play and argumentative essays. Data was collected using an analyzing instrument of student´s oral and written productions. In data analysis the privileged technique was content analysis. The results suggest that students mobilized requested scientific knowledge, showing improvement in the effective use of argumentation skills required. This allows us to conclude that the approach of controversial socio-scientific issues contributes to the promotion students´ argumentation skills as well as for scientific knowledge construction / mobilization.

  8. Mammography: review of the controversy, health disparities, and impact on young african american women. (United States)

    Kidd, April D; Colbert, Alison M; Jatoi, Ismail


    Ongoing debate about mammography screening for women in their 40s has brought awareness to the opportunities and challenges for achieving optimal breast health in young African American women and in battling health inequities that place them at greater risk for mortality from breast cancer. Despite the screening controversy, a need exists to understand the complex issues related to mammography knowledge, attitudes, and behaviors of young minority women, while empowering them to take an active role in their breast health care. The purpose of this article is to describe the complicated issues related to screening in young African American women within the context of the uncertainty about the evidence surrounding screening practices. Literature was reviewed to garner a comprehensive update of the mammography screening controversy and its impact on mammography practices. Nurses should be aware of the mammography screening controversy and breast cancer risk assessment and how they affect young women's participation in mammography screening. Mammography screening should be a shared decision between the patient and healthcare provider. A better understanding of breast health and its effect on young minority women is needed. Nurses have a prominent role to advocate for, empower, and educate patients as they face the task of deciding whether to begin or continue mammography in their 40s.

  9. Medical Experts and Agnotology in the Fumes Controversy of the Huelva Copper Mines (1888-1890). (United States)

    Guillem-Llobat, Ximo


    Huelva's copper mines (Spain) have been active for centuries but in the second half of the nineteenth century extractive activities in Riotinto, Tharsis, and other mines in the region were intensified in order to reach world leadership. The method used in these mines for copper extraction from low grade ores generated continuous emissions of fumes that were extremely controversial. The inhabitants had complained about the fumes for decades but as activity intensified so did complaints. The killing of anti-fumes demonstrators in 1888 led to the passing of a Royal Decree banning the open-air roasting of ore and to the drafting of numerous reports on the hazards of the fumes. Major state and provincial medical institutions, as well as renowned hygienists and engineers, took part in the assessment, contributing to a scientific controversy especially rich in content. In my paper I will analyse the production and circulation of knowledge and ignorance about the impact of fumes on public health, as well as the role of medical experts and expertise in the controversy. The analysis will focus on the reports drafted between the 1888 ban and its 1890 repeal, and will show the changing nature of the expert assessment and the numerous paths followed by experts in producing ignorance. The paper will conclude by considering other stakeholders, who may shed some light on the reasons behind the performance of the medical experts.

  10. Safe but controversial: A study of recent high-visibility spent fuel shipping campaigns

    International Nuclear Information System (INIS)

    Grimm, P.D.; Harmon, L.H.


    Since the need to move radioactive materials is at the core of every part of the fuel cycle, it is not surprising that the waste management program also has a critical transportation link. Yet, in spite of a nearly flawless safety record, transportation of spent fuel is an extremely controversial and emotional issue. There are reactions at every political level and pressures from special interest groups across the Nation. In many cases the courts make the final decisions. An example is the DOE program to move spent fuel from Brookhaven National Laboratory which took ten years to accomplish and wound up being decided by the U.S. Supreme Court. Two other DOE shipping campaigns now underway contain all of the same elements of controversy. About 35 - 40 rail shipments are intended to move the damaged Three-Mile Island core to DOE's Idaho facility. In addition, approximately 50 shipments of spent fuel will be made from the VEPCO plant at Surry, Virginia, to Idaho for use in testing above-ground storage methods. This paper traces the background of the campaigns and the controversies generated. Comparisons and contrasts of ''routine'' shipments of recent years with problems of today, including lawsuits to prevent shipment, are given along with implications for the future

  11. The Park 51/Ground Zero Controversy and Sacred Sites as Contested Space

    Directory of Open Access Journals (Sweden)

    Jeanne Halgren Kilde


    Full Text Available The Park 51 controversy swept like wildfire through the media in late August of 2010, fueled by Islamophobes who oppose all advance of Islam in America. Yet the controversy also resonated with many who were clearly not caught up in the fear of Islam. This article attempts to understand the broader concern that the Park 51 project would somehow violate the Ground Zero site, and, thus, as a sign of "respect" should be moved to a different location, an argument that was invariably articulated in “spatial language” as groups debated the physical and spatial presence of the buildings in question, their relative proximity, and even the shadows they cast. This article focuses on three sets of spatial meanings that undergirded these arguments: the site as sacred ground created through trauma, rebuilding as retaliation for the attack, and the assertion of American civil religion. The article locates these meanings within a broader civic discussion of liberty and concludes that the spatialization of the controversy opened up discursive space for repressive, anti-democratic views to sway even those who believe in religious liberty, thus evidencing a deep ambivalence regarding the legitimate civic membership of Muslim Americans.

  12. Anatomy of a health scare: education, income and the MMR controversy in the UK. (United States)

    Anderberg, Dan; Chevalier, Arnaud; Wadsworth, Jonathan


    The measles, mumps and rubella (MMR) controversy provides an interesting case where, for a short period of time, research publicized in the media, suggested a potential risk of serious side-effects associated with the vaccine, where there was also a sharp behavioral response from the public, and where the initial information was subsequently overturned. We consider the controversy from the perspective of health inequalities and the assimilation of information, focusing on whether and how vaccine uptake behavior in the wake of the controversy differed among groups of parents by education and income. Using panel data on the variation in the uptake of the MMR, and other childhood immunizations, across local Health Authority areas we find that the uptake rate of the MMR declined faster in areas where a larger fraction of parents had stayed in education past the age of 18 than in areas with less educated parents. We also find that the same areas reduced their relative uptake of other uncontroversial childhood immunizations, suggesting a "spillover" effect. Using a supplementary data source we find evidence of a corresponding positive income effect, indicating that wealthier parents avoided the MMR dilemma by purchasing single vaccines. Copyright © 2011 Elsevier B.V. All rights reserved.

  13. The London Spikes Controversy: Homelessness, Urban Securitisation and the Question of ‘Hostile Architecture’

    Directory of Open Access Journals (Sweden)

    James Petty


    Full Text Available This article examines an ostensibly new feature of the securitised urban landscape: ‘hostile architecture’. Following controversy in 2014 London over ‘anti-homeless spikes’– metal studs implanted at ground level designed to discourage the homeless from sleeping in otherwise unrestricted spaces – certain visible methods of environmental social control were temporarily subject to intense public scrutiny and debate. While contests over public and urban spaces are not new, the spikes controversy emerged in the context of broader socio-political and governmental shifts toward neoliberal arrangements. Using the spikes issue as a case study, I contextualise hostile architecture within these broader processes and in wider patterns of urban securitisation. The article then offers an explanatory framework for understanding the controversy itself. Ultimately the article questions whether the public backlash against the use of spikes indicates genuine resistance to patterns of urban securitisation or, counterintuitively, a broader public distaste for both the homeless and the mechanisms that regulate them. 

  14. Ancient DNA unravels the truth behind the controversial GUS Greenlandic Norse fur samples: the bison was a horse, and the muskox and beats were goats

    DEFF Research Database (Denmark)

    Sinding, Mikkel-Holger; Arneborg, Jette; Nyegaard, Georg


    The Norse Greenlandic archaeological site known as ‘the Farm Beneath the Sand’ (GUS) has sourced many well-preserved and unique archaeological artefacts. Some of the most controversial finds are tufts of hair, which previous morphological-based examination concluded derive from bison, black bear......, brown bear and muskox, all species whose natural presence in South Greenland is unlikely. If true, the consequences are potentially significant, as they could imply Viking trading with, or hunting within, North America. To validate these previous findings, we genetically profiled the samples, through...... mitochondrial 16S DNA analysis. The results revealed that the putative bison was, in fact horse, while the bears and muskox were goat. The results demonstrate the importance of using genetic analyses to validate results derived from morphological analyses on hair, in particular where such studies lead...

  15. Effectiveness of disinfection with alcohol 70% (w/v of contaminated surfaces not previously cleaned

    Directory of Open Access Journals (Sweden)

    Maurício Uchikawa Graziano

    Full Text Available OBJECTIVE: To evaluate the disinfectant effectiveness of alcohol 70% (w/v using friction, without previous cleaning, on work surfaces, as a concurrent disinfecting procedure in Health Services. METHOD: An experimental, randomized and single-blinded laboratory study was undertaken. The samples were enamelled surfaces, intentionally contaminated with Serratia marcescens microorganisms ATCC 14756 106 CFU/mL with 10% of human saliva added, and were submitted to the procedure of disinfection WITHOUT previous cleaning. The results were compared to disinfection preceded by cleaning. RESULTS: There was a reduction of six logarithms of the initial microbial population, equal in the groups WITH and WITHOUT previous cleaning (p=0.440 and a residual microbial load ≤ 102 CFU. CONCLUSION: The research demonstrated the acceptability of the practice evaluated, bringing an important response to the area of health, in particular to Nursing, which most undertakes procedures of concurrent cleaning /disinfecting of these work surfaces.

  16. Effectiveness of disinfection with alcohol 70% (w/v of contaminated surfaces not previously cleaned

    Directory of Open Access Journals (Sweden)

    Maurício Uchikawa Graziano


    Full Text Available OBJECTIVE: To evaluate the disinfectant effectiveness of alcohol 70% (w/v using friction, without previous cleaning, on work surfaces, as a concurrent disinfecting procedure in Health Services. METHOD: An experimental, randomized and single-blinded laboratory study was undertaken. The samples were enamelled surfaces, intentionally contaminated with Serratia marcescens microorganisms ATCC 14756 106 CFU/mL with 10% of human saliva added, and were submitted to the procedure of disinfection WITHOUT previous cleaning. The results were compared to disinfection preceded by cleaning. RESULTS: There was a reduction of six logarithms of the initial microbial population, equal in the groups WITH and WITHOUT previous cleaning (p=0.440 and a residual microbial load ≤ 102 CFU. CONCLUSION: The research demonstrated the acceptability of the practice evaluated, bringing an important response to the area of health, in particular to Nursing, which most undertakes procedures of concurrent cleaning /disinfecting of these work surfaces.

  17. Reoperative sentinel lymph node biopsy after previous mastectomy. (United States)

    Karam, Amer; Stempel, Michelle; Cody, Hiram S; Port, Elisa R


    Sentinel lymph node (SLN) biopsy is the standard of care for axillary staging in breast cancer, but many clinical scenarios questioning the validity of SLN biopsy remain. Here we describe our experience with reoperative-SLN (re-SLN) biopsy after previous mastectomy. Review of the SLN database from September 1996 to December 2007 yielded 20 procedures done in the setting of previous mastectomy. SLN biopsy was performed using radioisotope with or without blue dye injection superior to the mastectomy incision, in the skin flap in all patients. In 17 of 20 patients (85%), re-SLN biopsy was performed for local or regional recurrence after mastectomy. Re-SLN biopsy was successful in 13 of 20 patients (65%) after previous mastectomy. Of the 13 patients, 2 had positive re-SLN, and completion axillary dissection was performed, with 1 having additional positive nodes. In the 11 patients with negative re-SLN, 2 patients underwent completion axillary dissection demonstrating additional negative nodes. One patient with a negative re-SLN experienced chest wall recurrence combined with axillary recurrence 11 months after re-SLN biopsy. All others remained free of local or axillary recurrence. Re-SLN biopsy was unsuccessful in 7 of 20 patients (35%). In three of seven patients, axillary dissection was performed, yielding positive nodes in two of the three. The remaining four of seven patients all had previous modified radical mastectomy, so underwent no additional axillary surgery. In this small series, re-SLN was successful after previous mastectomy, and this procedure may play some role when axillary staging is warranted after mastectomy.

  18. Why is There so Much Controversy Regarding the Population Health Impact of the Great Recession? Reflections on Three Case Studies. (United States)

    Bacigalupe, Amaia; Shahidi, Faraz Vahid; Muntaner, Carles; Martín, Unai; Borrell, Carme


    In the aftermath of the Great Recession, public health scholars have grown increasingly interested in studying the health consequences of macroeconomic change. Reflecting existing debates on the nature of this relationship, research on the effects of the recent economic crisis has sparked considerable controversy. On the one hand there is evidence to support the notion that macroeconomic downturns are associated with positive health outcomes. On the other hand, a growing number of studies warn that the current economic crisis can be expected to pose serious problems for the public's health. This article contributes to this debate through a review of recent evidence from three case studies: Iceland, Spain, and Greece. It shows that the economic crisis has negatively impacted some population health indicators (e.g., mental health) in all three countries, but especially in Greece. Available evidence defies deterministic conclusions, including increasingly "conventional" claims about economic downturns improving life expectancy and reducing mortality. While our results echo previous research in finding that the relationship between economic crises and population health is complex, they also indicate that this complexity is not arbitrary. On the contrary, changing social and political contexts provide meaningful, if partial, explanations for the perplexing nature of recent empirical findings. © The Author(s) 2015.

  19. Hepatitis C virus and the controversial role of the interferon sensitivity determining region in the response to interferon treatment. (United States)

    Torres-Puente, Manuela; Cuevas, José M; Jiménez-Hernández, Nuria; Bracho, María A; García-Robles, Inmaculada; Carnicer, Fernando; del Olmo, Juan; Ortega, Enrique; Moya, Andrés; González-Candelas, Fernando


    The degree of variability of the interferon sensitivity determining region (ISDR) in the hepatitis C virus (HCV) genome has been postulated to predict the response to interferon therapy, mainly in patients infected with subtype 1b, although this prediction has been the subject of a long controversy. This prediction has been tested by analyzing a cohort of 67 Spanish patients infected with HCV genotype 1, 23 of which were infected with subtype 1a and 44 with subtype 1b. A sample previous to therapy with alpha-interferon plus ribavirin was obtained and several clones (between 25 and 96) including the ISDR were sequenced from each patient. A significant correlation between mutations at the ISDR and response to treatment for subtype 1b patients, but not for those infected with subtype 1a, has been detected. Although the results suggest that the same relationship holds true for subtype 1a, lack of statistical power because of the small sample size of this subtype prevented firmer conclusions. However, identical ISDR sequences were found in responder and non-responder patients, suggesting that the stability of the ISDR sequence can occasionally help HCV to evade interferon therapy, although this is not a sufficient condition. More complex interactions, including the ISDR or not, are likely to exist and govern the HCV response to interferon treatment. (Copyright) 2007 Wiley-Liss, Inc.

  20. The controversy over H5N1 transmissibility research: an opportunity to define a practical response to a global threat. (United States)

    Fedson, David S; Opal, Steven M


    Since December 2011, influenza virologists and biosecurity experts have been engaged in a controversial debate over research on the transmissibility of H5N1 influenza viruses. Influenza virologists disagreed with the NSABB's recommendation not to publish experimental details of their findings, whereas biosecurity experts wanted the details to be withheld and future research restricted. The virologists initially declared a voluntary moratorium on their work, but later the NSABB allowed their articles to be published, and soon transmissibility research will resume. Throughout the debate, both sides have had understandable views, but both have overlooked the more important question of whether anything could be done if one of these experimentally derived viruses or a naturally occurring and highly virulent influenza virus should emerge and cause a global pandemic. This is a crucial question, because during the 2009 H1N1 influenza pandemic, more than 90% of the world's people had no access to timely supplies of affordable vaccines and antiviral agents. Observational studies suggest that inpatient statin treatment reduces mortality in patients with laboratory-confirmed seasonal influenza. Other immunomodulatory agents (glitazones, fibrates and AMPK agonists) improve survival in mice infected with influenza viruses. These agents are produced as inexpensive generics in developing countries. If they were shown to be effective, they could be used immediately to treat patients in any country with a basic health care system. For this reason alone, influenza virologists and biosecurity experts need to join with public health officials to develop an agenda for laboratory and clinical research on these agents. This is the only approach that could yield practical measures for a global response to the next influenza pandemic.