WorldWideScience

Sample records for previous geodetic studies

  1. Geodetic Education

    OpenAIRE

    Tatiana Ozhereleva

    2013-01-01

    The article examines the state of modern geodetic education, considers the features of geodetic surveying as the labor market, analyzes the state of geodetic educational services as a basis of geodetic education. The paper uses materials of Russia's first international conference "International Association of Geodesy", held in September, 2012. The necessity for international accreditation of geodetic educational services was justified

  2. Error Propagation in Geodetic Networks Studied by FEMLAB

    DEFF Research Database (Denmark)

    Borre, Kai

    2009-01-01

    Geodetic networks can be described by discrete models. The observations may be height differences, distances, and directions. Geodesists always make more observations than necessary and estimate the solution by using the principle of least squares. Contemporary networks often contain several thou...

  3. A comparative study for the estimation of geodetic point velocity by ...

    Indian Academy of Sciences (India)

    Space geodesy era provides velocity information which results in the positioning of geodetic points by considering the time evolution. The geodetic point positions on the Earth's surface change over time due to plate tectonics, and these changes have to be accounted for geodetic purposes. The velocity field of geodetic ...

  4. Geodetic Control Points - National Geodetic Survey Benchmarks

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  5. A comparative study for the estimation of geodetic point velocity by ...

    Indian Academy of Sciences (India)

    emanated from tectonic plate movements and dis- placements associated with earthquakes can cause the geodetic points to move at predictable rates from year to year. These kinematic effects on the geodetic points can be defined by a phenomenon called point velocity (Mathews and Biediger. 2012). The most demanding ...

  6. A study of geodetic grids for the continuous, quasi real time alignment of the ATLAS semiconductor tracker

    International Nuclear Information System (INIS)

    Gibson, S.M.; Coe, P.A.; Mitra, A.; Howell, D.F.; Nickerson, R.B.

    2003-01-01

    An alignment system based on Frequency Scanning Interferometry has been developed to monitor shape changes of the ATLAS semiconductor tracker. Movements of the detector modules will be monitored in quasi real time by combining precise distance measurements between nodes of a geodetic grid attached to the support structure. The final geodetic grid will consist of eight hundred lines of sight in a complex geometry. As the first step in understanding such complex grids, several simple two and three dimensional prototype grids with adjustable geometry have been tested. Different opto-geometrical models of the grids have been used to reconstruct the node coordinates. Expected errors are compared with the spread on coordinates, reconstructed using different software models. Sensitivity to likely deformations of the ATLAS semiconductor tracker, as modelled with FEA and studies of error propagation through the final ATLAS grid will be discussed. (author)

  7. NChina16: A stable geodetic reference frame for geological hazard studies in North China

    Science.gov (United States)

    Wang, Guoquan; Bao, Yan; Gan, Weijun; Geng, Jianghui; Xiao, Gengru; Shen, Jack S.

    2018-04-01

    We have developed a stable North China Reference Frame 2016 (NChina16) using five years of continuous GPS observations (2011.8-2016.8) from 12 continuously operating reference stations (CORS) fixed to the North China Craton. Applications of NChina16 in landslide and subsidence studies are illustrated in this article. A method for realizing a regional geodetic reference frame is introduced. The primary result of this study is the seven parameters for transforming Cartesian ECEF (Earth-Centered, Earth-Fixed) coordinates X, Y, and Z from the International GNSS Service Reference Frame 2008 (IGS08) to NChina16. The seven parameters include the epoch that is used to align the regional reference frame to IGS08 and the time derivatives of three translations and three rotations. The GIPSY-OASIS (V6.4) software package was used to obtain the precise point positioning (PPP) daily solutions with respect to IGS08. The frame stability of NChina16 is approximately 0.5 mm/year in both horizontal and vertical directions. This study also developed a regional model for correcting seasonal motions superimposed into the vertical component of the GPS-derived displacement time series. Long-term GPS observations (1999-2016) from five CORS in North China were used to develop the seasonal model. According to this study, the PPP daily solutions with respect to NChina16 could achieve 2-3 mm horizontal accuracy and 4-5 mm vertical accuracy after being modified by the regional model. NChina16 will be critical to study geodynamic problems in North China, such as earthquakes, faulting, subsidence, and landslides. The regional reference frame will be periodically updated every few years to mitigate degradation of the frame with time and be synchronized with the update of IGS reference frame.

  8. A Possible Contribution of an Integrated Geodetic Infrastructure to EPOS: Case Study the Czech Republic

    Science.gov (United States)

    Simek, Jaroslav; Filler, Vratislav; Kostelecky, Jan; Kostelecky, Jakub; Novak, Pavel; Palinkas, Vojtech; Plicka, Vladimir; Valko, Milos

    2010-05-01

    The Earth is subject to a multitude of dynamic processes that cover a broad variety of spatial and temporal scales and are driven by large interior and exterior forces. The need for a global monitoring of the Earth has been recognized by the UN which resulted in initiating several global observing systems. None of these systems explicitly includes a geodetic component nor it is directly connected to the Global Geodetic Observing System. Nevertheless, only geodetic techniques can provide both the reference frame for Earth system observations as well as observations of crucial parameters related to changes in the Earth's geometry, rotation and gravity field. To ensure a long-term stability of the terrestrial reference system on the accuracy level of 1E-9 in the global and continental scale, the interactions between different time-dependent influences of the system Earth to the terrestrial reference system have to be considered. Therefore, necessary observations of different observation techniques must be available. To achieve reliable results, observations must be completed with meteorological parameters and environmental data of different kinds (ground water level, soil moisture etc.). A possible contribution of a regional geodetic infrastructure is illustrated by an example of the Geodetic Observatory Pecný, the Czech Republic, which continuously provides time series of GNSS, gravity (based on the absolute and superconducting gravimeters), seismic, environmental, climatological and meteorological (including radiometric atmosphere profiling) observations. Parallel to it, several data and analysis centers of the IAG international scientific services and of international geodynamical and meteorological projects are running at the observatory. The observatory is also a reference station for the scientific and experimental GNSS network operated in the Czech Republic and a part of the regional seismic network. Some time series of observations are presented and

  9. COORDINATE TRANSFORMATION USING FEATHERSTONE AND VANÍČEK PROPOSED APPROACH - A CASE STUDY OF GHANA GEODETIC REFERENCE NETWORK

    Directory of Open Access Journals (Sweden)

    Yao Yevenyo Ziggah

    2017-03-01

    Full Text Available Most developing countries like Ghana are yet to adopt the geocentric datum for its surveying and mapping purposes. It is well known and documented that non-geocentric datums based on its establishment have more distortions in height compared with satellite datums. Most authors have argued that combining such height with horizontal positions (latitude and longitude in the transformation process could introduce unwanted distortions to the network. This is because the local geodetic height in most cases is assumed to be determined to a lower accuracy compared with the horizontal positions. In the light of this, a transformation model was proposed by Featherstone and Vaníček (1999 which avoids the use of height in both global and local datums in coordinate transformation. It was confirmed that adopting such a method reduces the effect of distortions caused by geodetic height on the transformation parameters estimated. Therefore, this paper applied Featherstone and Vaníček (FV model for the first time to a set of common points coordinates in Ghana geodetic reference network. The FV model was used to transform coordinates from global datum (WGS84 to local datum (Accra datum. The results obtained based on the Root Mean Square Error (RMSE and Mean Absolute Error (MAE in both Eastings and Northings were satisfactory. Thus, a RMSE value of 0.66 m and 0.96 m were obtained for the Eastings and Northings while 0.76 m and 0.73 m were the MAE values achieved. Also, the FV model attained a transformation accuracy of 0.49 m. Hence, this study will serve as a preliminary investigation in avoiding the use of height in coordinate transformation within Ghana’s geodetic reference network.

  10. Modified geodetic brane cosmology

    International Nuclear Information System (INIS)

    Cordero, Rubén; Cruz, Miguel; Molgado, Alberto; Rojas, Efraín

    2012-01-01

    We explore the cosmological implications provided by the geodetic brane gravity action corrected by an extrinsic curvature brane term, describing a codimension-1 brane embedded in a 5D fixed Minkowski spacetime. In the geodetic brane gravity action, we accommodate the correction term through a linear term in the extrinsic curvature swept out by the brane. We study the resulting geodetic-type equation of motion. Within a Friedmann–Robertson–Walker metric, we obtain a generalized Friedmann equation describing the associated cosmological evolution. We observe that, when the radiation-like energy contribution from the extra dimension is vanishing, this effective model leads to a self-(non-self)-accelerated expansion of the brane-like universe in dependence on the nature of the concomitant parameter β associated with the correction, which resembles an analogous behaviour in the DGP brane cosmology. Several possibilities in the description for the cosmic evolution of this model are embodied and characterized by the involved density parameters related in turn to the cosmological constant, the geometry characterizing the model, the introduced β parameter as well as the dark-like energy and the matter content on the brane. (paper)

  11. VT Geodetic Control Monuments

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The GeodeticBenchmark_GEOMON data layer consists of geodetic control monuments (points) that have a known position or spatial reference. The...

  12. Analysis of geodetic and legal documentation in the process of expropriation for roads. Krakow case study

    Science.gov (United States)

    Trembecka, Anna

    2013-06-01

    Amendment to the Act on special rules of preparation and implementation of investment in public roads resulted in an accelerated mode of acquisition of land for the development of roads. The decision to authorize the execution of road investment issued on its basis has several effects, i.e. determines the location of a road, approves surveying division, approves construction design and also results in acquisition of a real property by virtue of law by the State Treasury or local government unit, among others. The conducted study revealed that over 3 years, in this mode, the city of Krakow has acquired 31 hectares of land intended for the implementation of road investments. Compensation is determined in separate proceedings based on an appraisal study estimating property value, often at a distant time after the loss of land by the owner. One reason for the lengthy compensation proceedings is challenging the proposed amount of compensation, unregulated legal status of the property as well as imprecise legislation. It is important to properly develop geodetic and legal documentation which accompanies the application for issuance of the decision and is also used in compensation proceedings. Zmiana ustawy o szczególnych zasadach przygotowywania i realizacji inwestycji w zakresie dróg publicznych spowodowała przyspieszony tryb pozyskiwania gruntów przeznaczonych pod budowę dróg. Wydawana na jej podstawie decyzja o zezwoleniu na realizację inwestycji drogowej wywołuje szereg skutków, tj. m.in. ustala lokalizację drogi, zatwierdza podziały geodezyjne, zatwierdza projekt budowlany a także powoduje nabycie nieruchomości z mocy prawa, przez Skarb Państwa lub jednostki samorządu terytorialnego. Przeprowadzone badania wykazały iż w powyższym trybie miasto Kraków nabyło w okresie 3 lat ponad 31 ha gruntów przeznaczonych na realizację inwestycji drogowych. Odszkodowanie ustalane jest w drodze odrębnego postępowania w oparciu o operat szacunkowy okre

  13. Monitoring ground deformation of cultural heritage sites using UAVs and geodetic techniques: the case study of Choirokoitia, JPI PROTHEGO project

    Science.gov (United States)

    Themistocleous, Kyriacos; Danezis, Chris; Mendonidis, Evangelos; Lymperopoulou, Efstathia

    2017-10-01

    This paper presents the integrated methods using UAVs and geodetic techniques to monitor ground deformation within the Choirokoitia UNESCO World Heritage Site in Cyprus. The Neolithic settlement of Choirokoitia, occupied from the 7th to the 4th millennium B.C., is one of the most important prehistoric sites in the eastern Mediterranean. The study is conducted under the PROTHEGO (PROTection of European Cultural HEritage from GeO-hazards) project, which is a collaborative research project funded in the framework of the Joint Programming Initiative on Cultural Heritage and Global Change (JPICH) - Heritage Plus in 2015-2018 (www.prothego.eu) and through the Cyprus Research Promotion Foundation. PROTHEGO aims to make an innovative contribution towards the analysis of geo-hazards in areas of cultural heritage, and uses novel space technology based on radar interferometry to retrieve information on ground stability and motion in the 400+ UNESCO's World Heritage List monuments and sites of Europe. The field measurements collected at the Choirokoitia site will be later compared with SAR data to verify micro-movements in the area to monitor potential geo-hazards. The site is located on a steep hill, which makes it vulnerable to rock falls and landslides.

  14. Geodetic Survey Water Level Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Over one million images of National Coast & Geodetic Survey (now NOAA's National Geodetic Survey/NGS) forms captured from microfiche. Tabular forms and charts...

  15. Geodetic SAR Tomography

    NARCIS (Netherlands)

    Zhu, Xiao Xiang; Montazeri, Sina; Gisinger, Christoph; Hanssen, R.F.; Bamler, Richard

    2016-01-01

    In this paper, we propose a framework referred to as 'geodetic synthetic aperture radar (SAR) tomography' that fuses the SAR imaging geodesy and tomographic SAR inversion (TomoSAR) approaches to obtain absolute 3-D positions of a large amount of natural scatterers. The methodology is applied on

  16. A Comparative Study of the Applied Methods for Estimating Deflection of the Vertical in Terrestrial Geodetic Measurements

    Directory of Open Access Journals (Sweden)

    Luca Vittuari

    2016-04-01

    Full Text Available This paper compares three different methods capable of estimating the deflection of the vertical (DoV: one is based on the joint use of high precision spirit leveling and Global Navigation Satellite Systems (GNSS, a second uses astro-geodetic measurements and the third gravimetric geoid models. The working data sets refer to the geodetic International Terrestrial Reference Frame (ITRF co-location sites of Medicina (Northern, Italy and Noto (Sicily, these latter being excellent test beds for our investigations. The measurements were planned and realized to estimate the DoV with a level of precision comparable to the angular accuracy achievable in high precision network measured by modern high-end total stations. The three methods are in excellent agreement, with an operational supremacy of the astro-geodetic method, being faster and more precise than the others. The method that combines leveling and GNSS has slightly larger standard deviations; although well within the 1 arcsec level, which was assumed as threshold. Finally, the geoid model based method, whose 2.5 arcsec standard deviations exceed this threshold, is also statistically consistent with the others and should be used to determine the DoV components where local ad hoc measurements are lacking.

  17. A Comparative Study of the Applied Methods for Estimating Deflection of the Vertical in Terrestrial Geodetic Measurements

    Science.gov (United States)

    Vittuari, Luca; Tini, Maria Alessandra; Sarti, Pierguido; Serantoni, Eugenio; Borghi, Alessandra; Negusini, Monia; Guillaume, Sébastien

    2016-01-01

    This paper compares three different methods capable of estimating the deflection of the vertical (DoV): one is based on the joint use of high precision spirit leveling and Global Navigation Satellite Systems (GNSS), a second uses astro-geodetic measurements and the third gravimetric geoid models. The working data sets refer to the geodetic International Terrestrial Reference Frame (ITRF) co-location sites of Medicina (Northern, Italy) and Noto (Sicily), these latter being excellent test beds for our investigations. The measurements were planned and realized to estimate the DoV with a level of precision comparable to the angular accuracy achievable in high precision network measured by modern high-end total stations. The three methods are in excellent agreement, with an operational supremacy of the astro-geodetic method, being faster and more precise than the others. The method that combines leveling and GNSS has slightly larger standard deviations; although well within the 1 arcsec level, which was assumed as threshold. Finally, the geoid model based method, whose 2.5 arcsec standard deviations exceed this threshold, is also statistically consistent with the others and should be used to determine the DoV components where local ad hoc measurements are lacking. PMID:27104544

  18. Automated and dynamic scheduling for geodetic VLBI - A simulation study for AuScope and global networks

    Science.gov (United States)

    Iles, E. J.; McCallum, L.; Lovell, J. E. J.; McCallum, J. N.

    2018-02-01

    As we move into the next era of geodetic VLBI, the scheduling process is one focus for improvement in terms of increased flexibility and the ability to react with changing conditions. A range of simulations were conducted to ascertain the impact of scheduling on geodetic results such as Earth Orientation Parameters (EOPs) and station coordinates. The potential capabilities of new automated scheduling modes were also simulated, using the so-called 'dynamic scheduling' technique. The primary aim was to improve efficiency for both cost and time without losing geodetic precision, particularly to maximise the uses of the Australian AuScope VLBI array. We show that short breaks in observation will not significantly degrade the results of a typical 24 h experiment, whereas simply shortening observing time degrades precision exponentially. We also confirm the new automated, dynamic scheduling mode is capable of producing the same standard of result as a traditional schedule, with close to real-time flexibility. Further, it is possible to use the dynamic scheduler to augment the 3 station Australian AuScope array and thereby attain EOPs of the current global precision with only intermittent contribution from 2 additional stations. We thus confirm automated, dynamic scheduling bears great potential for flexibility and automation in line with aims for future continuous VLBI operations.

  19. Calibration of Geodetic Instruments

    Directory of Open Access Journals (Sweden)

    Marek Bajtala

    2005-06-01

    Full Text Available The problem of metrology and security systems of unification, correctness and standard reproducibilities belong to the preferred requirements of theory and technical practice in geodesy. Requirements on the control and verification of measured instruments and equipments increase and the importance and up-to-date of calibration get into the foreground. Calibration possibilities of length-scales (of electronic rangefinders and angle-scales (of horizontal circles of geodetic instruments. Calibration of electronic rangefinders on the linear comparative baseline in terrain. Primary standard of planar angle – optical traverse and its exploitation for calibration of the horizontal circles of theodolites. The calibration equipment of the Institute of Slovak Metrology in Bratislava. The Calibration process and results from the calibration of horizontal circles of selected geodetic instruments.

  20. Radon anomalies prior to earthquakes (1). Review of previous studies

    International Nuclear Information System (INIS)

    Ishikawa, Tetsuo; Tokonami, Shinji; Yasuoka, Yumi; Shinogi, Masaki; Nagahama, Hiroyuki; Omori, Yasutaka; Kawada, Yusuke

    2008-01-01

    The relationship between radon anomalies and earthquakes has been studied for more than 30 years. However, most of the studies dealt with radon in soil gas or in groundwater. Before the 1995 Hyogoken-Nanbu earthquake, an anomalous increase of atmospheric radon was observed at Kobe Pharmaceutical University. The increase was well fitted with a mathematical model related to earthquake fault dynamics. This paper reports the significance of this observation, reviewing previous studies on radon anomaly before earthquakes. Groundwater/soil radon measurements for earthquake prediction began in 1970's in Japan as well as foreign countries. One of the most famous studies in Japan is groundwater radon anomaly before the 1978 Izu-Oshima-kinkai earthquake. We have recognized the significance of radon in earthquake prediction research, but recently its limitation was also pointed out. Some researchers are looking for a better indicator for precursors; simultaneous measurements of radon and other gases are new trials in recent studies. Contrary to soil/groundwater radon, we have not paid much attention to atmospheric radon before earthquakes. However, it might be possible to detect precursors in atmospheric radon before a large earthquake. In the next issues, we will discuss the details of the anomalous atmospheric radon data observed before the Hyogoken-Nanbu earthquake. (author)

  1. Geodetic achievement and avoidance games for graphs | Haynes ...

    African Journals Online (AJOL)

    Let G = (V,E) be a nontrivial connected graph. For a subset S ⊆ V, the geodesic closure (S) of S is the set of all vertices on geodesics (shortest paths) between two vertices of S. We study the geodetic achievement and avoidance games defined by Buckley and Harary (Geodetic games for graphs, Quaestiones Math.

  2. Global geodetic observatories

    Science.gov (United States)

    Boucher, Claude; Pearlman, Mike; Sarti, Pierguido

    2015-01-01

    Global geodetic observatories (GGO) play an increasingly important role both for scientific and societal applications, in particular for the maintenance and evolution of the reference frame and those applications that rely on the reference frame for their viability. The International Association of Geodesy (IAG), through the Global Geodetic Observing System (GGOS), is fully involved in coordinating the development of these systems and ensuring their quality, perenniality and accessibility. This paper reviews the current role, basic concepts, and some of the critical issues associated with the GGOs, and advocates for their expansion to enhance co-location with other observing techniques (gravity, meteorology, etc). The historical perspective starts with the MERIT campaign, followed by the creation of international services (IERS, IGS, ILRS, IVS, IDS, etc). It provides a basic definition of observing systems and observatories and the build up of the international networks and the role of co-locations in geodesy and geosciences and multi-technique processing and data products. This paper gives special attention to the critical topic of local surveys and tie vectors among co-located systems in sites; the agreement of space geodetic solutions and the tie vectors now place one of the most significant limitations on the quality of integrated data products, most notably the ITRF. This topic focuses on survey techniques, extrapolation to instrument reference points, computation techniques, systematic biases, and alignment of the individual technique reference frames into ITRF. The paper also discusses the design, layout and implementation of network infrastructure, including the role of GGOS and the benefit that would be achieved with better standardization and international governance.

  3. Geodesy introduction to geodetic datum and geodetic systems

    CERN Document Server

    Lu, Zhiping; Qiao, Shubo

    2014-01-01

    A full introduction to geodetic data and systems written by well-known experts in their respective fields, this book is an ideal text for courses in geodesy and geomatics covering everything from coordinate and gravimetry data to geodetic systems of all types.

  4. New study reveals twice as many asteroids as previously believed

    Science.gov (United States)

    2002-05-01

    The ISO satellite Credits: ESA ISO An artist's impression of the ISO spacecraft. The ISO Deep Asteroid Search indicates that there are between 1.1 million and 1.9 million 'space rocks' larger than 1 kilometre in diameter in the so-called 'main asteroid belt', about twice as many as previously believed. However, astronomers think it is premature to revise current assessments of the risk of the Earth being hit by an asteroid. Despite being in our own Solar System, asteroids can be more difficult to study than very distant galaxies. With sizes of up to one thousand kilometres in diameter, the brightness of these rocky objects may vary considerably in just a few minutes. They move very quickly with respect to the stars - they have been dubbed 'vermin of the sky' because they often appear as trails on long exposure images. This elusiveness explains why their actual number and size distribution remains uncertain. Most of the almost 40,000 asteroids catalogued so far (1) orbit the Sun forming the 'main asteroid belt', between Mars and Jupiter, too far to pose any threat to Earth. However, space-watchers do keep a closer eye on another category of asteroids, the 'Near Earth Asteroids' or 'NEAs', which are those whose orbits cross, or are likely to cross, that of our planet. The ISO Deep Asteroid Search (IDAS), the first systematic search for these objects performed in infrared light, focused on main belt asteroids. Because it is impossible to simply point the telescope at the whole main belt and count, astronomers choose selected regions of the belt and then use a theoretical model to extrapolate the data to the whole belt. Edward Tedesco (TerraSystems, Inc., New Hampshire, United States) and François-Xavier Desert (Observatoire de Grenoble, France) observed their main belt selected areas in 1996 and 1997 with ESA's ISO. They found that in the middle region of the belt the density of asteroids was 160 asteroids larger than 1 kilometre per square degree - an area of the

  5. Efficient transformations from geodetic to UTM coordinate systems

    Energy Technology Data Exchange (ETDEWEB)

    Toms, R.M.

    1996-08-07

    The problem of efficiently performing transformations from geocentric to geodetic coordinates has been addressed at previous DIS (Distributed Interactive Simulation) workshops. This paper extends the work presented at the 14th DIS Workshop. As a consequence of the new algorithm for geocentric to geodetic coordinate conversion, a subsequent conversion to Universal Transverse Mercator coordinates is made considerably more efficient. No additional trigonometric or square root evaluations are required and accuracy is not degraded.

  6. A Spatial Energy Balance Index to Analyze Geodetic and Seismic Time Series: The Eastern Flank of Mt. Etna Case Study

    Science.gov (United States)

    Cannavo', Flavio; Arena, Alessandra; Mattia, Mario; Monaco, Carmelo

    2013-04-01

    In line with the aim of analyzing multivariate datasets, in this paper we propose a new methodology to merge different types of instrumental data, such as deformation data and seismic data, in order to extract and compare the common information about earthquake cycles. In particular, the development of large Continuously-operating Global Positioning System (CGPS) networks in recent years, has allowed measuring detailed surface deformations, generally used to obtain information on the strain accumulation along fault systems. The challenge is to combine the geodetic information coming from the CGPS networks with the seismic data from the earthquake databases. Here, we propose a Spatial Energy Balance Index (SEBI) which takes into account the accumulated geodetic strain and the seismically-released strain to quantify a balance of the energies, according to the elastic rebound theory. Indeed, a fault, being subjected to force and shift, accumulates energy and slowly deforms until its internal strength is exceeded, then releasing the accumulated energy. The proposed index synthesizes the energy state of an area, revealing possible dynamics of earthquake occurrences. Furthermore, the paper sets out a novel technique for GPS displacement interpolation. The interpolation takes into account the GPS network topology and the topography effects to estimate the continuous displacement field at the surface. The technique is a combination of techniques coming from soft-computing algorithms; in particular, it is based on Cellular Automata and Artificial Neural Networks. The whole process of data interpolation and index setting is mainly data-driven and consists of two steps: the first of model identification and a second step of testing. The proposed approach was applied to the Eastern flank of Mt. Etna (Italy) for the period 2008-2012. Results quantify the energy state of different faults of the Mt. Etna's Eastern flank.

  7. A preliminary geodetic data model for geographic information systems

    Science.gov (United States)

    Kelly, K. M.

    2009-12-01

    Our ability to gather and assimilate integrated data collections from multiple disciplines is important for earth system studies. Moreover, geosciences data collection has increased dramatically, with pervasive networks of observational stations on the ground, in the oceans, in the atmosphere and in space. Contemporary geodetic observations from several space and terrestrial technologies contribute to our knowledge of earth system processes and thus are a valuable source of high accuracy information for many global change studies. Assimilation of these geodetic observations and numerical models into models of weather, climate, oceans, hydrology, ice, and solid Earth processes is an important contribution geodesists can make to the earth science community. Clearly, the geodetic observations and models are fundamental to these contributions. ESRI wishes to provide leadership in the geodetic community to collaboratively build an open, freely available content specification that can be used by anyone to structure and manage geodetic data. This Geodetic Data Model will provide important context for all geographic information. The production of a task-specific geodetic data model involves several steps. The goal of the data model is to provide useful data structures and best practices for each step, making it easier for geodesists to organize their data and metadata in a way that will be useful in their data analyses and to their customers. Built on concepts from the successful Arc Marine data model, we introduce common geodetic data types and summarize the main thematic layers of the Geodetic Data Model. These provide a general framework for envisioning the core feature classes required to represent geodetic data in a geographic information system. Like Arc Marine, the framework is generic to allow users to build workflow or product specific geodetic data models tailored to the specific task(s) at hand. This approach allows integration of the data with other existing

  8. National Geodetic Survey (NGS) Geodetic Control Stations, (Horizontal and/or Vertical Control), March 2009

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  9. National Geodetic Control Stations, Geographic NAD83, NGS (2004) [geodetic_ctrl_point_la_NGS_2004

    Data.gov (United States)

    Louisiana Geographic Information Center — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  10. Geodetic and seismological investigation in the Ionian area

    Directory of Open Access Journals (Sweden)

    F. Riguzzi

    1997-06-01

    Full Text Available Geodetic and seismic evidence of crustal deformations in the Ionian area are shown in this paper. The Ionian GPS network, composed of nine sites crossing the Ionian Sea from Calabria, Southern Italy, to Northwestern Greece, was established and surveyed in 1991, 1994, 1995 within the framework of the TYRGEONET project (Anzidei et al., 1996. In 1996 a return campaign was carried out after the occurrence of seismic activity in 1995. The displacement pattern obtained for the Greek side of the network agrees well with those previously displayed, both in magnitude and direction, confirming a mean displacement rate of about 1-2 cm1/yr. The same agreement is not found for the Italian side of the network, where no significant deformations were detected between 1994 and 1996. Seismic deformation was also studied for the same area, starting from the moment tensors of events which occurred in the last 20 years with magnitude greater than 5.0; evident similarity with the displacement field exhibited by the Greek side of the Ionian Sea by geodetic surveys was inferred. On the contrary, the motion detected for the Italian area cannot be simply related to seismic activity.

  11. National Geodetic Survey's Airport Aerial Photography

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Geodetic Survey (NGS), formerly part of the U.S. Coast and Geodetic Survey, has been performing Aeronautical surveys since the 1920's. NGS, in...

  12. An integrated geodetic and seismic study of the Cusco Fault system in the Cusco Region-Southern Peru

    Science.gov (United States)

    Norabuena, E. O.; Tavera, H. J.

    2017-12-01

    The Cusco Fault system is composed by six main faults (Zurite, Tamboray, Qoricocha, Tambomachay, Pachatusan, and Urcos) extending in a NW-SE direction over the Cusco Region in southeastern Peru. From these, the Tambomachay is a normal fault of 20 km length, strikes N120°E and bounds a basin filled with quaternary lacustrine and fluvial deposits. Given its 5 km distance to Cusco, an historical and Inca's archeological landmark, it represents a great seismic hazard for its more than 350,000 inhabitants. The Tambomachay fault as well as the other secondary faults have been a source of significant seismic activity since historical times being the more damaging ones the Cusco earthquakes of 1650, 1950 and more recently April 1986 (M 5.8). Previous geological studies indicate that at the beginning of the Quaternary the fault showed a transcurrent mechanism leading to the formation of the Cusco basin. However, nowadays its mechanism is normal fault and scarps up to 22m can be observed. We report the current dynamics of the Tambomachay fault and secondary faults based on seismic activity imaged by a network of 29 broadband stations deployed in the Cusco Region as well as the deformation field inferred from GPS survey measurements carried out between 2014 and 2016.

  13. Is the Okavango Delta the terminus of the East African Rift System? Towards a new geodynamic model: Geodetic study and geophysical review

    Science.gov (United States)

    Pastier, Anne-Morwenn; Dauteuil, Olivier; Murray-Hudson, Michael; Moreau, Frédérique; Walpersdorf, Andrea; Makati, Kaelo

    2017-08-01

    The Okavango Graben (OG) has been considered as the terminus of the southwestern branch of the East African Rift System (EARS) since the 1970s based on fault morphology and early seismic and geophysical data. Thus it has been assumed to be an incipient rifting zone, analogous to the early stage of mature rifts in the EARS. Recent geodetic data and geophysical studies in the area bring new insights into the local crust and lithosphere, mantle activity and fault activity. In this study, we computed the velocities for three permanent GPS stations surrounding the graben and undertook a review of the new geophysical data available for the area. The northern and southern blocks of the graben show an exclusively low strike-slip displacement rate of about 1mm/year, revealing the transtensional nature of this basin. The seismic record of central and southern Africa was found to be instrumentally biased for the events recorded before 2004 and the OG may not represent the most seismically active area in Botswana anymore. Moreover, no significant lithosphere and crustal thinning is found in the tectonic structure nor any strong negative Bouguer anomaly and surface heat flux. Thus the OG does not match the classical model for a rifting zone. We propose a new geodynamic model for the deformation observed west of the EARS based on accommodation of far-field deformation due to the differential extension rates of the EARS and the displacement of the Kalahari craton relative to the Nubian plate.

  14. Added-value joint source modelling of seismic and geodetic data

    Science.gov (United States)

    Sudhaus, Henriette; Heimann, Sebastian; Walter, Thomas R.; Krueger, Frank

    2013-04-01

    In tectonically active regions earthquake source studies strongly support the analysis of the current faulting processes as they reveal the location and geometry of active faults, the average slip released or more. For source modelling of shallow, moderate to large earthquakes often a combination of geodetic (GPS, InSAR) and seismic data is used. A truly joint use of these data, however, usually takes place only on a higher modelling level, where some of the first-order characteristics (time, centroid location, fault orientation, moment) have been fixed already. These required basis model parameters have to be given, assumed or inferred in a previous, separate and highly non-linear modelling step using one of the these data sets alone. We present a new earthquake rupture model implementation that realizes a fully combined data integration of surface displacement measurements and seismic data in a non-linear optimization of simple but extended planar ruptures. The model implementation allows for fast forward calculations of full seismograms and surface deformation and therefore enables us to use Monte Carlo global search algorithms. Furthermore, we benefit from the complementary character of seismic and geodetic data, e. g. the high definition of the source location from geodetic data and the sensitivity of the resolution of the seismic data on moment releases at larger depth. These increased constraints from the combined dataset make optimizations efficient, even for larger model parameter spaces and with a very limited amount of a priori assumption on the source. A vital part of our approach is rigorous data weighting based on the empirically estimated data errors. We construct full data error variance-covariance matrices for geodetic data to account for correlated data noise and also weight the seismic data based on their signal-to-noise ratio. The estimation of the data errors and the fast forward modelling opens the door for Bayesian inferences of the source

  15. Geodetic Control Information on Passive Marks: Horizontal and Vertical Geodetic Control Data for the United States - National Geospatial Data Asset (NGDA) Geodetic Control Information on Passive Marks

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  16. 40 CFR 152.93 - Citation of a previously submitted valid study.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Citation of a previously submitted... Data Submitters' Rights § 152.93 Citation of a previously submitted valid study. An applicant may... the citation is necessary. (b) Study previously submitted by another person. If the applicant is not...

  17. Use of Geodetic Surveys of Leveling Lines and Dry Tilt Arrays to Study Faults and Volcanoes in Undergraduate Field Geophysics Classes

    Science.gov (United States)

    Polet, J.; Alvarez, K.; Elizondo, K.

    2017-12-01

    In the early 1980's and 1990's numerous leveling lines and dry tilt arrays were installed throughout Central and Southern California by United States Geological Survey scientists and other researchers (e.g. Sylvester, 1985). These lines or triangular arrays of geodetic monuments commonly straddle faults or have been installed close to volcanic areas, where significant motion is expected over relatively short time periods. Over the past year, we have incorporated geodetic surveys of these arrays as part of our field exercises in undergraduate and graduate level classes on topics such as shallow subsurface geophysics and field geophysics. In some cases, the monuments themselves first had to be located based on only limited information, testing students' Brunton use and map reading skills. Monuments were then surveyed using total stations and global navigation satellite system (GNSS) receivers, using a variety of experimental procedures. The surveys were documented with tables, photos, maps and graphs in field reports, as well as in wiki pages created by student groups for a geophysics field class this June. The measurements were processed by the students and compared with similar data from surveys conducted soon after installation of the arrays, to analyze the deformation that occurred over the last few decades. The different geodetic techniques were also compared and an error analysis was conducted. The analysis and processing of these data challenged and enhanced students' quantitative literacy and technology skills. The final geodetic measurements are being incorporated into several senior and MSc thesis projects. Further surveys are planned for additional classes, in topics that could include seismology, geodesy, volcanology and global geophysics. We are also considering additional technologies, such as structure from motion (SfM) photogrammetry.

  18. The evidences of progressive pressurization of volcanic conduit as driving forces of unrest phenomena analyzed via modelling of multiplatform geodetic measurements: Fernandina (GALAPAGOS) and Maunaloa (HAWAII) case studies

    Science.gov (United States)

    Pepe, Susi; Castaldo, Raffaele; Casu, Francesco; D'Auria, Luca; De Luca, Claudio; De Novellis, Vincenzo; Solaro, Giuseppe; Tizzani, Pietro

    2017-04-01

    collection, we determined the source responsible of deformation observed and in particular the results of our inversions show that the pipe source contributes substantially to both the ground deformation pattern and the cost function. In the case of Fernandina Volcano (Galápagos) we exploited the advanced Differential SAR Interferometry (DInSAR) techniques to analyze the 2012-2013 uplift episode by using X-band data from the COSMO-SkyMed (CSK) satellite constellation. This volcano falls among those not well monitored, therefore, the availability of CSK data, acquired with a repeat time ranging from 4 to 12 days and with a ground resolution of 3 meters, represents a unique opportunity to perform a detailed study of the space and time ground deformation field changes (Sansosti et al., 2014). In addition, in this case study we computed the ground deformation time series by applying the Small BAseline Subset (SBAS)-DInSAR approach (Berardino et al., 2002) to CSK data, acquired from both ascending and descending orbits. The results of their combination (vertical and horizontal E-W components) are used in order to evaluate, through a cross correlation analysis (Tizzani et al., 2009; 2015), the volcanic areas that are characterized by similar uplift temporal behavior. Subsequently, we determine the geometry, location and the temporal evolution of the geodetic source responsible for the 2012 - 2013 uplift event by applying an inverse method to the DInSAR measurements. We search for its geometrical parameters and volume variation that minimize the difference between the observed data and the modelled ground deformation field. We tested various analytical models and finally, using the Akaike Information Criterion (Akaike, 1965) among the tested analytical sources, we selected the tilted pipe. The pipe model is similar to the prolate ellipsoid, but the size of the smaller axis is kept fixed to a very small value (i.e., 10 m). Despite having a similar fit with the prolate ellipsoid

  19. Leveraging geodetic data to reduce losses from earthquakes

    Science.gov (United States)

    Murray, Jessica R.; Roeloffs, Evelyn A.; Brooks, Benjamin A.; Langbein, John O.; Leith, William S.; Minson, Sarah E.; Svarc, Jerry L.; Thatcher, Wayne R.

    2018-04-23

    Seismic hazard assessments that are based on a variety of data and the best available science, coupled with rapid synthesis of real-time information from continuous monitoring networks to guide post-earthquake response, form a solid foundation for effective earthquake loss reduction. With this in mind, the Earthquake Hazards Program (EHP) of the U.S. Geological Survey (USGS) Natural Hazards Mission Area (NHMA) engages in a variety of undertakings, both established and emergent, in order to provide high quality products that enable stakeholders to take action in advance of and in response to earthquakes. Examples include the National Seismic Hazard Model (NSHM), development of tools for improved situational awareness such as earthquake early warning (EEW) and operational earthquake forecasting (OEF), research about induced seismicity, and new efforts to advance comprehensive subduction zone science and monitoring. Geodetic observations provide unique and complementary information directly relevant to advancing many aspects of these efforts (fig. 1). EHP scientists have long leveraged geodetic data for a range of influential studies, and they continue to develop innovative observation and analysis methods that push the boundaries of the field of geodesy as applied to natural hazards research. Given the ongoing, rapid improvement in availability, variety, and precision of geodetic measurements, considering ways to fully utilize this observational resource for earthquake loss reduction is timely and essential. This report presents strategies, and the underlying scientific rationale, by which the EHP could achieve the following outcomes: The EHP is an authoritative source for the interpretation of geodetic data and its use for earthquake loss reduction throughout the United States and its territories.The USGS consistently provides timely, high quality geodetic data to stakeholders.Significant earthquakes are better characterized by incorporating geodetic data into USGS

  20. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  1. Identification of multidrug resistance in previously treated tuberculosis patients: a mixed methods study in Cambodia

    Science.gov (United States)

    Royce, S; Khann, S; Yadav, RP; Mao, ET; Cattamanchi, A; Sam, S; Handley, MA

    2014-01-01

    SUMMARY Setting Previously treated tuberculosis (TB) patients are a priority for drug susceptibility testing (DST) to identify cases with multidrug resistance (MDR). In Cambodia, a recent study found that only one-third of smear-positive previously treated patients had DST results. Objective To quantify the gaps in detecting MDR in previously treated TB patients in Cambodia, and describe health workers’ perspectives on barriers, facilitators and potential interventions. Design We analyzed case notifications in Cambodia (2004–2012) and conducted semi-structured interviews with key stakeholders Results The proportion of previously treated notifications varied significantly across provinces 2010–12, in the context of longer term trends of decreasing relapse and increasing “other” retreatment notifications. Correct classification of patients’ TB treatment history and ensuring specimens from previously-treated patients are collected and reach the laboratory could nearly double the number of detected MDR-TB cases. Identified barriers include patients’ reluctance to disclose and staff difficulty eliciting treatment history, partly due to availability of streptomycin only in hospitals. Facilitators include trained health workers, collection of sputum for DST even if previously treated patients are not taking streptomycin, streamlining sputum transportation and promptly reporting results. Conclusion Improved monitoring, supportive supervision, and correctly classifying previously treated patients are essential for improving detection of MDR-TB. PMID:25299861

  2. Matched cohort study of external cephalic version in women with previous cesarean delivery.

    Science.gov (United States)

    Keepanasseril, Anish; Anand, Keerthana; Soundara Raghavan, Subrahmanian

    2017-07-01

    To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included. Characteristics and outcomes were compared between groups. ECV was successful for 32 (84.2%) of 38 women with previous cesarean delivery and 62 (81.6%) in the control group (P=0.728). Multivariate regression analysis confirmed that previous cesarean was not associated with ECV success (odds ratio 1.89, 95% confidence interval 0.19-18.47; P=0.244). Successful vaginal delivery after successful ECV was reported for 19 (59.4%) women in the previous cesarean delivery group and 52 (83.9%) in the control group (Pcesarean delivery. To avoid a repeat cesarean delivery, ECV can be offered to women with breech presentation and previous cesarean delivery who are otherwise eligible for a trial of labor. © 2017 International Federation of Gynecology and Obstetrics.

  3. Investigating Strain Transfer Along the Southern San Andreas Fault: A Geomorphic and Geodetic Study of Block Rotation in the Eastern Transverse Ranges, Joshua Tree National Park, CA

    Science.gov (United States)

    Guns, K. A.; Bennett, R. A.; Blisniuk, K.

    2017-12-01

    To better evaluate the distribution and transfer of strain and slip along the Southern San Andreas Fault (SSAF) zone in the northern Coachella valley in southern California, we integrate geological and geodetic observations to test whether strain is being transferred away from the SSAF system towards the Eastern California Shear Zone through microblock rotation of the Eastern Transverse Ranges (ETR). The faults of the ETR consist of five east-west trending left lateral strike slip faults that have measured cumulative offsets of up to 20 km and as low as 1 km. Present kinematic and block models present a variety of slip rate estimates, from as low as zero to as high as 7 mm/yr, suggesting a gap in our understanding of what role these faults play in the larger system. To determine whether present-day block rotation along these faults is contributing to strain transfer in the region, we are applying 10Be surface exposure dating methods to observed offset channel and alluvial fan deposits in order to estimate fault slip rates along two faults in the ETR. We present observations of offset geomorphic landforms using field mapping and LiDAR data at three sites along the Blue Cut Fault and one site along the Smoke Tree Wash Fault in Joshua Tree National Park which indicate recent Quaternary fault activity. Initial results of site mapping and clast count analyses reveal at least three stages of offset, including potential Holocene offsets, for one site along the Blue Cut Fault, while preliminary 10Be geochronology is in progress. This geologic slip rate data, combined with our new geodetic surface velocity field derived from updated campaign-based GPS measurements within Joshua Tree National Park will allow us to construct a suite of elastic fault block models to elucidate rates of strain transfer away from the SSAF and how that strain transfer may be affecting the length of the interseismic period along the SSAF.

  4. Geodetic Network Design and Optimization on the Active Tuzla Fault (Izmir, Turkey for Disaster Management

    Directory of Open Access Journals (Sweden)

    Haluk Ozener

    2008-08-01

    Full Text Available Both seismological and geodynamic research emphasize that the Aegean Region, which comprises the Hellenic Arc, the Greek mainland and Western Turkey is the most seismically active region in Western Eurasia. The convergence of the Eurasian and African lithospheric plates forces a westward motion on the Anatolian plate relative to the Eurasian one. Western Anatolia is a valuable laboratory for Earth Science research because of its complex geological structure. Izmir is a large city in Turkey with a population of about 2.5 million that is at great risk from big earthquakes. Unfortunately, previous geodynamics studies performed in this region are insufficient or cover large areas instead of specific faults. The Tuzla Fault, which is aligned trending NE–SW between the town of Menderes and Cape Doganbey, is an important fault in terms of seismic activity and its proximity to the city of Izmir. This study aims to perform a large scale investigation focusing on the Tuzla Fault and its vicinity for better understanding of the region's tectonics. In order to investigate the crustal deformation along the Tuzla Fault and Izmir Bay, a geodetic network has been designed and optimizations were performed. This paper suggests a schedule for a crustal deformation monitoring study which includes research on the tectonics of the region, network design and optimization strategies, theory and practice of processing. The study is also open for extension in terms of monitoring different types of fault characteristics. A one-dimensional fault model with two parameters – standard strike-slip model of dislocation theory in an elastic half-space – is formulated in order to determine which sites are suitable for the campaign based geodetic GPS measurements. Geodetic results can be used as a background data for disaster management systems.

  5. Developing Reading Comprehension through Metacognitive Strategies: A Review of Previous Studies

    Science.gov (United States)

    Channa, Mansoor Ahmed; Nordin, Zaimuariffudin Shukri; Siming, Insaf Ali; Chandio, Ali Asgher; Koondher, Mansoor Ali

    2015-01-01

    This paper has reviewed the previous studies on metacognitive strategies based on planning, monitoring, and evaluating in order to develop reading comprehension. The main purpose of this review in metacognition, and reading domain is to help readers to enhance their capabilities and power reading through these strategies. The researchers reviewed…

  6. Study of some physical aspects previous to design of an exponential experiment

    International Nuclear Information System (INIS)

    Caro, R.; Francisco, J. L. de

    1961-01-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs

  7. A Geodetic Strain Rate Model for the East African Rift System.

    Science.gov (United States)

    Stamps, D S; Saria, E; Kreemer, C

    2018-01-15

    Here we describe the new Sub-Saharan Africa Geodetic Strain Rate Model v.1.0 (SSA-GSRM v.1.0), which provides fundamental constraints on long-term tectonic deformation in the region and an improved seismic hazards assessment in Sub-Saharan Africa. Sub-Saharan Africa encompasses the East African Rift System, the active divergent plate boundary between the Nubian and Somalian plates, where strain is largely accommodated along the boundaries of three subplates. We develop an improved geodetic strain rate field for sub-Saharan Africa that incorporates 1) an expanded geodetic velocity field, 2) redefined regions of deforming zones guided by seismicity distribution, and 3) updated constraints on block rotations. SSA-GSRM v.1.0 spans longitudes 22° to 55.5° and latitudes -52° to 20° with 0.25° (longitude) by 0.2° (latitude) spacing. For plates/sub-plates, we assign rigid block rotations as constraints on the strain rate calculation that is determined by fitting bicubic Bessel splines to a new geodetic velocity solution for an interpolated velocity gradient tensor field. We derive strain rates, velocities, and vorticity rates from the velocity gradient tensor field. A comparison with the Global Geodetic Strain Rate model v2.1 reveals regions of previously unresolved spatial heterogeneities in geodetic strain rate distribution, which indicates zones of elevated seismic risk.

  8. Study of functional-performance deficits in athletes with previous ankle sprains

    Directory of Open Access Journals (Sweden)

    hamid Babaee

    2008-04-01

    Full Text Available Abstract Background: Despite the importance of functional-performance deficits in athletes with history of ankle sprain few, studies have been carried out in this area. The aim of this research was to study relationship between previous ankle sprains and functional-performance deficits in athletes. Materials and methods: The subjects were 40 professional athletes selected through random sampling among volunteer participants in soccer, basketball, volleyball and handball teams of Lorestan province. The subjects were divided into 2 groups: Injured group (athletes with previous ankle sprains and healthy group (athletes without previous ankle sprains. In this descriptive study we used Functional-performance tests (figure 8 hop test and side hop test to determine ankle deficits and limitations. They participated in figure 8 hop test including hopping in 8 shape course with the length of 5 meters and side hop test including 10 side hop repetitions in course with the length of 30 centimeters. Time were recorded via stopwatch. Results: After data gathering and assessing information distributions, Pearson correlation was used to assess relationships, and independent T test to assess differences between variables. Finally the results showed that there is a significant relationship between previous ankle sprains and functional-performance deficits in the athletes. Conclusion: The athletes who had previous ankle sprains indicated functional-performance deficits more than healthy athletes in completion of mentioned functional-performance tests. The functional-performance tests (figure 8 hop test and side hop test are sensitive and suitable to assess and detect functional-performance deficits in athletes. Therefore we can use the figure 8 hop and side hop tests for goals such as prevention, assessment and rehabilitation of ankle sprains without spending too much money and time.

  9. Previous treatment influences fingolimod efficacy in relapsing-remitting multiple sclerosis: results from an observational study.

    Science.gov (United States)

    Baldi, Eleonora; Guareschi, Angelica; Vitetta, Francesca; Senesi, Caterina; Curti, Erica; Montepietra, Sara; Simone, Anna Maria; Immovilli, Paolo; Caniatti, Luisa; Tola, Maria Rosaria; Pesci, Ilaria; Montanari, Enrico; Sola, Patrizia; Granella, Franco; Motti, Luisa; Ferraro, Diana

    2014-09-01

    Fingolimod (FTY) is licensed as a disease-modifying treatment in highly active relapsing-remitting multiple sclerosis. The aim of the study was to evaluate the efficacy and safety of FTY in a real-life setting and to explore the possible role of clinical and MRI parameters, including previous treatment type, in predicting its efficacy. Clinical and MRI data was collected on 127 patients assigned to treatment with FTY in six multiple sclerosis centers in Emilia-Romagna, Italy, between August 2011 and June 2013. During a mean follow-up period of 10 months (range 1-22), we observed a total of 47 relapses in 39 patients (30.7%); new T2 lesions or gadolinium-enhancing (Gd+) lesions were present at follow-up MRI in 32/71 patients (45%). Expanded disability status scale (EDSS) at the end of the follow-up period was not different when compared to the baseline EDSS. Serious adverse events occurred in three patients (2.4%). A higher proportion of patients previously treated with natalizumab showed clinical (41%) or MRI activity (54%). Previous treatment with natalizumab increased the risk of a relapse within 30 days (versus immunomodulatory drugs; OR: 4.3; p = 0.011) and at survival analysis (versus remaining patients; HR: 1.9; p = 0.046). Study limitations include a small population sample, a short observation period with variable timing of follow-up MRI and different baseline characteristics of patients previously treated with natalizumab compared to those treated with immunomodulatory drugs. This study confirms the efficacy of FTY in reducing relapse rate in patients previously treated with immunomodulatory drugs, while it seems to be less effective in patients discontinuing natalizumab. Due to the short duration of follow-up it is not possible to evaluate disability progression; however, no difference was observed between the groups.

  10. Previous infection and the risk of ischaemic stroke in Italy: the IN2 study.

    Science.gov (United States)

    Consoli, D; Vidale, S; Aguglia, U; Bassi, P; Cavallini, A; Galati, F; Guidetti, D; Marcello, N; Micieli, G; Pracucci, G; Rasura, M; Siniscalchi, A; Sterzi, R; Toni, D; Inzitari, D

    2015-03-01

    There is an increasing interest in new risk factors for ischaemic stroke. Acute and chronic infections could contribute to different aetiological mechanisms of atherosclerosis that lead to cerebrovascular disease. The aim of this study was to investigate the hypothesis that previous infections and Chlamydia pneumoniae in particular increase the risk of ischaemic stroke in the population. This was a prospective case-control study involving 11 Italian stroke units. Controls were age- and sex-matched with cases, represented by patients admitted to hospital for acute ischaemic stroke. For each participant classical vascular risk factors and previous inflammatory and infectious events up to 1 month before were registered. Blood samples were collected to analyse inflammatory markers and titres of antibodies against C. pneumoniae. A total of 1002 participants were included (mean age 69 years) with 749 ischaemic stroke patients. Infections occurred within 1 month previously in 12% of the entire sample with a higher prevalence in the case group (14.4% vs. 3.9%). At multivariate analysis of the seropositivity of IgA antibodies against C. pneumoniae increased the risk of stroke significantly (relative risk 2.121; 95% confidence interval 1.255-3.584) and an early previous infection (up to 7 days before the event) contributed to a rise in probability of acute cerebral ischaemia (relative risk 3.692; 95% confidence interval 1.134-6.875). Early previous infections and persistent chronic infection of C. pneumoniae could contribute to increase the risk of ischaemic stroke significantly, in the elderly especially. © 2014 EAN.

  11. HIV-related neuropsychological impairment in patients with previous substance use: A preliminary study

    OpenAIRE

    García-Torres, Amalia; Vergara-Moragues, Esperanza (UNIR); Piñón-Blanco, Adolfo; Pérez-García, Miguel

    2015-01-01

    Human immunodeficiency virus (HIV) can result in cognitive disorders that significantly interfere with the daily activities of HIV patients. These disorders may be worse when there is a history of psychoactive substance use. Our objective is to assess the neuropsychological profile in a group of HIV patients with previous drug use compared to a group of HIV-negative patients with a history of drug use. The study included a total of 28 Spanish adult subjects, of which 14 were HIV-infected and ...

  12. Data from studies of previous radioactive waste disposal in Massachusetts Bay

    International Nuclear Information System (INIS)

    Curtis, W.R.; Mardis, H.M.

    1984-12-01

    This report presents the results of studies conducted in Massachusetts Bay during 1981 and 1982. Included are data from: (1) a side scan sonar survey of disposal areas in the Bay that was carried out by the National Oceanic and Atmospheric Administration (NOAA) for EPA; (2) Collections of sediment and biota by NOAA for radiochemical analysis by EPA; (3) collections of marketplace seafood samples by the Food and Drug Administration (FDA) for radioanalysis by both FDA and EPA; and (4) a radiological monitoring survey of LLW disposal areas by EPA to determine whether there should be any concern for public health resulting from previous LLW disposals in the Bay

  13. Cystic echinococcosis in Jordan: A review of causative species, previous studies, serological and radiological diagnosis.

    Science.gov (United States)

    Hijjawi, Nawal S; Al-Radaideh, Ali M; Rababah, Eman M; Al-Qaoud, Khaled M; Bani-Hani, Kamal E

    2018-03-01

    Cystic echinococcosis (CE)/hydatidosis is a zoonotic disease which occur in human and herbivore animals as a result of infection with the larval stage of the taeniid cestode Echinococcus granulosus sensu lato (s. l.). In human, CE is a serious public health concern in many parts of the world including Jordan. The present review will cover CE causative agent: E. granulosus species/genotypes; life cycle of E. granulosus parasite, all published previous studies on CE in Jordan (humans, intermediate hosts, definitive host) as well as its diagnostic methods in human. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Testing and calibration of geodetic instruments

    Directory of Open Access Journals (Sweden)

    Marek Bajtala

    2007-06-01

    Full Text Available The problem of testing, verification and calibration of length-scales (electronic rangefinders and angle-scales (geodetic instruments. The calibration of coded levelling rods and the systemic calibration of digital levelling instruments. The calibration on linear comparative baseline in a terrain – the elaboration of measured data. The testing of universal measuring instruments in laboratory conditions - specific problems in testing of instruments with the passive reflection. Some knowledge about the calibration of horizontal circles of angle-measuring geodetic instruments.

  15. Does the previous diagnosis of arterial hypertension affect one's daily life? Pro-Saude Study.

    Science.gov (United States)

    Goffredo Filho, Gilberto Senechal de; Lopes, Claudia de Souza; Faerstein, Eduardo

    2013-12-01

    In addition to damaging several target organs, arterial hypertension may negatively impact patients' activities of daily living. Biological and behavioral mechanisms underlying such limitations have yet to be clarified. The objectives of this study were to investigate whether having been previously told of a hypertension diagnosis is associated with the frequency and duration of temporary limitations in activities of daily living, and whether these relationships differ by gender, age, or socioeconomic position. We analyzed sectional data from 2,666 participants (56% women; 55% with high school or lower schooling) at the baseline phase (1999 - 2001) of a longitudinal investigation of university employees in Rio de Janeiro, Brazil (Pró-Saúde Study), asking participants whether they had ever been diagnosed with hypertension by a health professional, if they had been unable to perform any activities of daily living due to a health problem in the previous 2 weeks, and for how many days that had occurred. Multinomial logistic regression models were fitted for the overall study population and for age, gender, educational level, and per capita household income strata. Associations between hypertension diagnosis and temporary limitations were not observed in the overall study population and in gender, education and income strata. However, there were higher odds of temporary limitations among participants aged 55 years old or more with hypertension diagnosis (adjusted OR = 9.5; 95%CI 1.5 - 58.6), regardless of blood pressure levels and use of antihypertensive medication. Elderly people may keep an attitude of higher vigilance regarding conditions or events potentially worsening their health status.

  16. A longitudinal study of plasma insulin and glucagon in women with previous gestational diabetes

    DEFF Research Database (Denmark)

    Damm, P; Kühl, C; Hornnes, P

    1995-01-01

    OBJECTIVE: To investigate whether plasma insulin or glucagon predicts later development of diabetes in women with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: The subjects studied were 91 women with diet-treated GDM and 33 healthy women. Plasma insulin and glucagon during a 50...... at follow-up (2 had insulin-dependent diabetes mellitus, 13 had non-insulin-dependent diabetes mellitus, and 12 had impaired glucose tolerance). Compared with the control subjects, women with previous GDM had relatively impaired insulin secretion (decreased insulinogenic index and delayed peak insulin...... for subsequent development of overt diabetes (logistic regression analysis). CONCLUSIONS: Women who develop GDM have a relative insulin secretion deficiency, the severity of which is predictive for later development of diabetes. Furthermore, our data indicate that their relatively reduced beta-cell function may...

  17. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    International Nuclear Information System (INIS)

    Abulí, Anna; Morillas, Juan D; Rigau, Joaquim; Latorre, Mercedes; Fernández-Bañares, Fernando; Peña, Elena; Riestra, Sabino; Payá, Artemio; Jover, Rodrigo; Xicola, Rosa M; Llor, Xavier; Fernández-Rozadilla, Ceres; Carvajal-Carmona, Luis; Villanueva, Cristina M; Moreno, Victor; Piqué, Josep M; Carracedo, Angel; Castells, Antoni; Andreu, Montserrat; Ruiz-Ponte, Clara; Castellví-Bel, Sergi; Alonso-Espinaco, Virginia; Muñoz, Jenifer; Gonzalo, Victoria; Bessa, Xavier; González, Dolors; Clofent, Joan; Cubiella, Joaquin

    2011-01-01

    Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1 [rs698 in ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive), rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive), rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant), and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1

  18. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    Directory of Open Access Journals (Sweden)

    Moreno Victor

    2011-08-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. Methods CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. Results None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive, rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive, rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant, and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive. In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1

  19. A study about the interest and previous contact of high school students with Astronomy

    Science.gov (United States)

    Carvalho, C. L.; Zanitti, M. H. R.; Felicidade, B. L.; Gomes, A. D. T.; Dias, E. W.; Coelho, F. O.

    2016-04-01

    The currently problems in Astronomy teaching in Brazilian Basic Education contrast with the space, and the popularity that astronomical themes have in various media in the country. In this work, we present the results of a study about the interest, and previous contact of high school students from a public school in the city of "São João del-Rei"/MG with topics related to Astronomy. The study and the pedagogical intervention were carried out by students of the PIBID/CAPES/UFSJ. The intervention was performed through an oral exposition with the students' participation, followed by the use of the Stellarium program. The results suggest the majority of students surveyed are interested in Astronomy, and have had some contact with the area. However, some inconsistencies in their responses were identified and examined. The implications for research and for Astronomy Education are discussed. We also make some considerations about relationship between the lack of specific knowledge and the misinformation as one possible reason for the little interest of students in various areas of Science.

  20. An improved algorithm for geocentric to geodetic coordinate conversion

    Energy Technology Data Exchange (ETDEWEB)

    Toms, R.

    1996-02-01

    The problem of performing transformations from geocentric to geodetic coordinates has received an inordinate amount of attention in the literature. Numerous approximate methods have been published. Almost none of the publications address the issue of efficiency and in most cases there is a paucity of error analysis. Recently there has been a surge of interest in this problem aimed at developing more efficient methods for real time applications such as DIS. Iterative algorithms have been proposed that are not of optimal efficiency, address only one error component and require a small but uncertain number of relatively expensive iterations for convergence. In a recent paper published by the author a new algorithm was proposed for the transformation of geocentric to geodetic coordinates. The new algorithm was tested at the Visual Systems Laboratory at the Institute for Simulation and Training, the University of Central Florida, and found to be 30 percent faster than the best previously published algorithm. In this paper further improvements are made in terms of efficiency. For completeness and to make this paper more readable, it was decided to revise the previous paper and to publish it as a new report. The introduction describes the improvements in more detail.

  1. Biosystematic studies on Dactylis L. l. Review of the previous studies. 1.2. Cytology, genetics, experimental studies, and evolution

    Directory of Open Access Journals (Sweden)

    Marta Mizianty

    2014-01-01

    Full Text Available In this paper the author presents a review of the previous studies on Dactylis L., dealing with cytology,genetics, experimental studies and evolution. Following cytotypes of Dactylis are distributed mostly in Central Europe: 16 diploids, 7 tetraploids and also 2 hexaploids in North Africa. Some aneuploids and accessory chromosomes were also found in this genus. Data dealing with karyotypes of some taxa, and geographical distribution of cytotypes are also listed. Selected problems concerning crossing within diploids as well as tetraploids and also between diploids and teraploids were presented. Some opinions regarding the evolution in the genus Dactylis were also demonstrated. In all these hypotheses the following diploids are considered to be the oldest: D. smithii Link subsp. smithii, D. g. subsp. aschersoniana (Greabn. Thell. and D. g. subsp. himalayensis Dom.

  2. The biomechanics of running in athletes with previous hamstring injury: A case-control study.

    Science.gov (United States)

    Daly, C; Persson, U McCarthy; Twycross-Lewis, R; Woledge, R C; Morrissey, D

    2016-04-01

    Hamstring injury is prevalent with persistently high reinjury rates. We aim to inform hamstring rehabilitation by exploring the electromyographic and kinematic characteristics of running in athletes with previous hamstring injury. Nine elite male Gaelic games athletes who had returned to sport after hamstring injury and eight closely matched controls sprinted while lower limb kinematics and muscle activity of the previously injured biceps femoris, bilateral gluteus maximus, lumbar erector spinae, rectus femoris, and external oblique were recorded. Intergroup comparisons of muscle activation ratios and kinematics were performed. Previously injured athletes demonstrated significantly reduced biceps femoris muscle activation ratios with respect to ipsilateral gluteus maximus (maximum difference -12.5%, P = 0.03), ipsilateral erector spinae (maximum difference -12.5%, P = 0.01), ipsilateral external oblique (maximum difference -23%, P = 0.01), and contralateral rectus femoris (maximum difference -22%, P = 0.02) in the late swing phase. We also detected sagittal asymmetry in hip flexion (maximum 8°, P = 0.01), pelvic tilt (maximum 4°, P = 0.02), and medial rotation of the knee (maximum 6°, P = 0.03) effectively putting the hamstrings in a lengthened position just before heel strike. Previous hamstring injury is associated with altered biceps femoris associated muscle activity and potentially injurious kinematics. These deficits should be considered and addressed during rehabilitation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Volcano deformation--Geodetic monitoring techniques

    Science.gov (United States)

    Dzurisin, Daniel; Lu, Zhong

    2007-01-01

    This book describes the techniques used by volcanologists to successfully predict several recent volcanic eruptions by combining information from various scientific disciplines, including geodetic techniques. Many recent developments in the use of state-of-the-art and emerging techniques, including Global Positioning System and Synthetic Aperture Radar Interferometry, mean that most books on volcanology are out of date, and this book includes chapters devoted entirely to these two techniques.

  4. 3D geodetic monitoring slope deformations

    Directory of Open Access Journals (Sweden)

    Weiss Gabriel

    1996-06-01

    Full Text Available For plenty of slope failures that can be found in Slovakia is necessary and very important their geodetic monitoring (because of their activity, reactivisations, checks. The paper gives new methodologies for these works, using 3D terrestrial survey technologies for measurements in convenient deformation networks. The design of an optimal type of deformation model for various kinds of landslides and their exact processing with an efficient testing procedure to determine the kinematics of the slope deformations are presented too.

  5. Rancidity inhibition study in frozen whole mackerel (scomber scombrus by a previous plant extract treatment.

    Directory of Open Access Journals (Sweden)

    Aubourg, Santiago P.

    2005-09-01

    Full Text Available The effect of flaxseeds (Linum usitatissimum on rancidity development in frozen whole mackerel (Scomber scombrus was studied. For it, fresh mackerel were dipped in flaxseeds aqueous extract during 60 min, frozen at –80 ºC during 24 hours and kept frozen (–20 ºC up to 12 months. Sampling was carried out on the initial material and at months 1, 3, 5, 7, 9 and 12 of frozen storage at –20 ºC. A parallel experiment with non treated fish was carried out in the same conditions. Rancidity development was measured by several biochemical indices (free fatty acids, peroxides, conjugated dienes and trienes, secondary oxidation products and lipoxygenase activity and complemented by the sensory analysis (skin, flesh odour, consistency and flesh appearance. As a result of the previous antioxidant treatment, peroxides showed to breakdown faster (pSe ha estudiado el efecto del lino (Linum usitatissimum en el desarrollo de rancidez en caballa entera congelada (Scomber scombrus. Para ello, caballas frescas fueron sumergidas en extractos acuosos de semillas de lino durante 60 min, congeladas a -80 ºC durante 24 h y mantenidas congeladas ( -20 ºC durante 12 meses. Se tomaron muestras del material inicial y tras 1, 3, 5, 7, 9 y 12 meses de congelación a -20 ºC . Un experimento paralelo con pescado no tratado fue llevado acabo en las mismas condiciones. El desarrollo de la rancidez fue medido por varios índices bioquímicos (ácidos grasos libres, peróxidos, dienos y trienos conjugados, productos secundarios de oxidación y actividad lipoxigenasa y completado con análisis sensorial (piel, olor de la carne, consistencia y apariencia de la carne. Como resultado del tratamiento antioxidante, los peróxidos se degradaron más rápidos (p < 0.05 después del mes 7, y por tanto, contenidos mayores (p < 0.05 de dienos y trienos conjugados pudieron ser detectados en el pescado tratado. El tratamiento antioxidante también condujo a un

  6. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats

    Science.gov (United States)

    Gallardo-Calero, Irene; López-Fernández, Alba; Romagosa, Cleofe; Vergés, Ramona; Aguirre-Canyadell, Marius; Soldado, Francisco; Velez, Roberto

    2016-01-01

    Background: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. Methods: One hundred forty male Sprague–Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy). Clinical parameters, technical values of anastomosis, patency, and histopathological parameters were evaluated. Results: Irradiated groups (III and IV) and vein anastomosis groups (II and IV) showed significantly increased technical difficulties. Group IV showed significantly reduced patency rates (7/35) when compared with the control group (0/35). Radiotherapy significantly decreased the patency rates of the vein (7/35) when compared with the artery (1/35). Groups III and IV showed significantly reduced number of endothelial cells and also showed the presence of intimal thickening and adventitial fibrosis as compared with the control group. Conclusion: Neoadjuvant radiotherapy reduces the viability of the venous anastomosis in a preclinical rat model with a significant increase in the incidence of vein thrombosis. PMID:27975009

  7. The impacts of source structure on geodetic parameters demonstrated by the radio source 3C371

    Science.gov (United States)

    Xu, Ming H.; Heinkelmann, Robert; Anderson, James M.; Mora-Diaz, Julian; Karbon, Maria; Schuh, Harald; Wang, Guang L.

    2017-07-01

    Closure quantities measured by very-long-baseline interferometry (VLBI) observations are independent of instrumental and propagation instabilities and antenna gain factors, but are sensitive to source structure. A new method is proposed to calculate a structure index based on the median values of closure quantities rather than the brightness distribution of a source. The results are comparable to structure indices based on imaging observations at other epochs and demonstrate the flexibility of deriving structure indices from exactly the same observations as used for geodetic analysis and without imaging analysis. A three-component model for the structure of source 3C371 is developed by model-fitting closure phases. It provides a real case of tracing how the structure effect identified by closure phases in the same observations as the delay observables affects the geodetic analysis, and investigating which geodetic parameters are corrupted to what extent by the structure effect. Using the resulting structure correction based on the three-component model of source 3C371, two solutions, with and without correcting the structure effect, are made. With corrections, the overall rms of this source is reduced by 1 ps, and the impacts of the structure effect introduced by this single source are up to 1.4 mm on station positions and up to 4.4 microarcseconds on Earth orientation parameters. This study is considered as a starting point for handling the source structure effect on geodetic VLBI from geodetic sessions themselves.

  8. Late preterm birth and previous cesarean section: a population-based cohort study.

    Science.gov (United States)

    Yasseen Iii, Abdool S; Bassil, Kate; Sprague, Ann; Urquia, Marcelo; Maguire, Jonathon L

    2018-02-21

    Late preterm birth (LPB) is increasingly common and associated with higher morbidity and mortality than term birth. Yet, little is known about the influence of previous cesarean section (PCS) and the occurrence of LPB in subsequent pregnancies. We aim to evaluate this association along with the potential mediation by cesarean sections in the current pregnancy. We use population-based birth registry data (2005-2012) to establish a cohort of live born singleton infants born between 34 and 41 gestational weeks to multiparous mothers. PCS was the primary exposure, LPB (34-36 weeks) was the primary outcome, and an unplanned or emergency cesarean section in the current pregnancy was the potential mediator. Associations were quantified using propensity weighted multivariable Poisson regression, and mediating associations were explored using the Baron-Kenny approach. The cohort included 481,531 births, 21,893 (4.5%) were LPB, and 119,983 (24.9%) were predated by at least one PCS. Among mothers with at least one PCS, 6307 (5.26%) were LPB. There was increased risk of LPB among women with at least one PCS (adjusted Relative Risk (aRR): 1.20 (95%CI [1.16, 1.23]). Unplanned or emergency cesarean section in the current pregnancy was identified as a strong mediator to this relationship (mediation ratio = 97%). PCS was associated with higher risk of LPB in subsequent pregnancies. This may be due to an increased risk of subsequent unplanned or emergency preterm cesarean sections. Efforts to minimize index cesarean sections may reduce the risk of LPB in subsequent pregnancies.

  9. Radon diffusion coefficients for soils. Previous studies and their application to uranium-bearing wastes

    International Nuclear Information System (INIS)

    Sasaki, Tomozo; Gunji, Yasuyoshi; Iida, Takao

    2008-01-01

    Radon diffusion in soils has been studied over the years by many researchers. The application of such studies to the evaluation of radiation exposure caused by radon from uranium-bearing wastes disposed in a shallow land site is very important. The present paper surveyed closely relevant studies and elucidated the inherent nature of radon diffusion in terms of the definition of radon diffusion coefficients. Then, basic features of measurement methods for determining radon diffusion coefficients in soils were explained. Furthermore, theoretical aspects of radon diffusion in soils were discussed in terms of microscopic radon diffusion in soils and large-scale radon diffusion through cover soil defects for uranium mill tailings. Finally, in order to apply the radon diffusion studies to uranium-bearing waste disposal in shallow land sites, new challenges were presented: elucidation of radon diffusion in uranium-bearing wastes and cover-soil cracks, and demonstration of the validity of applying only radon diffusion in the evaluation of radiation exposure caused by radon, which would come through Japanese cover soils for uranium-bearing waste disposal. (author)

  10. A time marker instrument for kinematics movement studies: a development of previous versions

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Laburú

    2009-03-01

    Full Text Available This article presents a time marker to study movements in kinematics. It contributes to elaborate a version of time marker which low cost and more efficient in comparison with the marker presented in another work as well as the earlier commercial version.

  11. Ostrogradski Hamiltonian approach for geodetic brane gravity

    International Nuclear Information System (INIS)

    Cordero, Ruben; Molgado, Alberto; Rojas, Efrain

    2010-01-01

    We present an alternative Hamiltonian description of a branelike universe immersed in a flat background spacetime. This model is named geodetic brane gravity. We set up the Regge-Teitelboim model to describe our Universe where such field theory is originally thought as a second order derivative theory. We refer to an Ostrogradski Hamiltonian formalism to prepare the system to its quantization. This approach comprize the manage of both first- and second-class constraints and the counting of degrees of freedom follows accordingly.

  12. Segmental hair analysis after a single dose of zolpidem: comparison with a previous study.

    Science.gov (United States)

    Cui, Xiaopei; Xiang, Ping; Zhang, Jingshuo; Shi, Yan; Shen, Baohua; Shen, Min

    2013-01-01

    Hair is a useful aid and sometimes even the only matrix in the analytical strategy in drug-facilitated crime (DFC) investigations. In this novel study, segmental hair analysis was performed after a single 10 mg dose of zolpidem was given to 20 Chinese volunteers. Hair was collected 1 month after administration and was analyzed using ultra-high-pressure liquid chromatography/electrospray ionization tandem mass spectrometry. Zolpidem concentrations were found to be in the range of 135.0-554.6 pg/mg in the proximal 0-2 cm segments. These results were markedly different from those reported by Villain et al., who used volunteers administered equal doses of zolpidem. The analytical method used, as well as the volunteers' hair color, inter-individual variations such as metabolic capacity, hair growth rate, drug incorporation rates, physical state of the hair, age, gender, body weight, etc. and diffusion from sweat or other secretions are all factors that should be considered when interpreting the DFC results.

  13. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    International Nuclear Information System (INIS)

    Makhlouf, Ali; Serradj, Tayeb; Cheniti, Hamza

    2015-01-01

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10 3 MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO 2 eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10 −6 t NMVOC eq and 259.3 × 10 −6 t SO 2 eq respectively

  14. Geodetic sensor systems and sensor networks : Positioning and applications

    NARCIS (Netherlands)

    Verhagen, S.; Grejner-Brzezinska, D.; Retscher, G.; Santos, M.; Ding, X.; Gao, Y.; Jin, S.

    2009-01-01

    This contribution focuses on geodetic sensor systems and sensor networks for positioning and applications. The key problems in this area will be addressed together with an overview of applications. Global Navigation Satellite Systems (GNSS) and other geodetic techniques play a central role in many

  15. Effect of Acupressure, Acupuncture and Moxibustion in Women With Pregnancy-Related Anxiety and Previous Depression: A Preliminary Study

    OpenAIRE

    Suzuki, Shunji; Tobe, Chiharu

    2017-01-01

    Background In this preliminary study, we examined the effect of acupressure, acupuncture and moxibustion (oriental treatments) to prevent of the relapse/deterioration of perinatal depression in women with pregnancy-related anxiety and previous depression. Methods and results Between 2014 and 2016, there were 48 women with pregnancy-related anxiety and previous depression who had delivery at ? 22 weeks? gestation in our institute. Of these, oriental treatments were performed in eight and two w...

  16. A development of a mobile hydraulic pressure gauge for seafloor geodetic measurements and data evaluation of field studies conducted in the Nankai Trough

    Science.gov (United States)

    Kimura, T.; Machida, Y.; Nishida, S.; Araki, E.; Matsumoto, H.; Kawaguchi, K.

    2015-12-01

    A precise hydraulic pressure measurement is important in order to obtain geophysical knowledge associated with the occurrence of large interplate earthquakes. However, pressure measurements contain instrumental drift in a sensor in addition to the pressure changes related to a crustal deformations. Therefore a correction of the drift using an absolute calibration system is necessary. We developed a mobile pressure gauge. The mobile pressure gauge has a quartz water pressure meter (Paroscientific Inc. 410K) as a pressure sensor with pressure holding system due to heating of a pressure piping. The system enables us to maintain a constant pressure of a target field pressure from a laboratory to a seafloor in order to eliminate effects of pressure hysteresis of the sensor. Laboratory experiments showed a temperature characteristics and hysteresis of the sensor in addition to the pressure hysteresis. Because a temperature of the sensor is affected by an outside temperature which ranges from 2 degrees (at the bottom of the sea) to room temperature, we need to calibrate outputs values of the sensor using calibration values estimated by laboratory experiments. These procedure would improve the measurement accuracy and contribute to obtaining a small amount of crustal deformations related to occurrence of large interplate earthquakes. In the Nankai trough, we deployed a long-term borehole monitoring system with pressure gauges into the C0002 boreholes. Because the data are available in a real time, the observatory is good target for the calibration study. During the KY15-05 cruise, we deployed the mobile pressure gauge on the C0002 observatory using a ROV twice. A repeatability measurements between two dives indicates 2.55 hPa, which is equivalent to 2.55 cm converted into cm. And a repeatability measurements before and after the cruise indicates 3.56 hPa. In the presentation, we examine the calibration results with consideration of a characteristics of the pressure sensor

  17. Estimating the effect of current, previous and never use of drugs in studies based on prescription registries

    DEFF Research Database (Denmark)

    Nielsen, Lars Hougaard; Løkkegaard, Ellen; Andreasen, Anne Helms

    2009-01-01

    PURPOSE: Many studies which investigate the effect of drugs categorize the exposure variable into never, current, and previous use of the study drug. When prescription registries are used to make this categorization, the exposure variable possibly gets misclassified since the registries do not ca...

  18. DETECTION OF COASTLINE DEFORMATION USING REMOTE SENSING AND GEODETIC SURVEYS

    Directory of Open Access Journals (Sweden)

    A. Sabuncu

    2016-06-01

    Full Text Available The coastal areas are being destroyed due to the usage that effect the natural balance. Unconsciously sand mining from the sea for nearshore nourishment and construction uses are the main ones. Physical interferences for mining of sand cause an ecologic threat to the coastal environment. However, use of marine sand is inevitable because of economic reasons or unobtainable land-based sand resources. The most convenient solution in such a protection–usage dilemma is to reduce negative impacts of sand production from marine. This depends on the accurate determination of criteriaon production place, style, and amount of sand. With this motivation, nearshore geodedic surveying studies performed on Kilyos Campus of Bogazici University located on the Black Sea coast, north of Istanbul, Turkey between 2001-2002. The study area extends 1 km in the longshore. Geodetic survey was carried out in the summer of 2001 to detect the initial condition for the shoreline. Long-term seasonal changes in shoreline positions were determined biannually. The coast was measured with post-processed kinematic GPS. Besides, shoreline change has studied using Landsat imagery between the years 1986-2015. The data set of Landsat 5 imageries were dated 05.08.1986 and 31.08.2007 and Landsat 7 imageries were dated 21.07.2001 and 28.07.2015. Landcover types in the study area were analyzed on the basis of pixel based classification method. Firstly, unsupervised classification based on ISODATA (Iterative Self Organizing Data Analysis Technique has been applied and spectral clusters have been determined that gives prior knowledge about the study area. In the second step, supervised classification was carried out by using the three different approaches which are minimum-distance, parallelepiped and maximum-likelihood. All pixel based classification processes were performed with ENVI 4.8 image processing software. Results of geodetic studies and classification outputs will be

  19. Plate motions and deformations from geologic and geodetic data

    Science.gov (United States)

    Jordan, T. H.

    1986-06-01

    Research effort on behalf of the Crustal Dynamics Project focused on the development of methodologies suitable for the analysis of space-geodetic data sets for the estimation of crustal motions, in conjunction with results derived from land-based geodetic data, neo-tectonic studies, and other geophysical data. These methodologies were used to provide estimates of both global plate motions and intraplate deformation in the western U.S. Results from the satellite ranging experiment for the rate of change of the baseline length between San Diego and Quincy, California indicated that relative motion between the North American and Pacific plates over the course of the observing period during 1972 to 1982 were consistent with estimates calculated from geologic data averaged over the past few million years. This result, when combined with other kinematic constraints on western U.S. deformation derived from land-based geodesy, neo-tectonic studies, and other geophysical data, places limits on the possible extension of the Basin and Range province, and implies significant deformation is occurring west of the San Andreas fault. A new methodology was developed to analyze vector-position space-geodetic data to provide estimates of relative vector motions of the observing sites. The algorithm is suitable for the reduction of large, inhomogeneous data sets, and takes into account the full position covariances, errors due to poorly resolved Earth orientation parameters and vertical positions, and reduces baises due to inhomogeneous sampling of the data. This methodology was applied to the problem of estimating the rate-scaling parameter of a global plate tectonic model using satellite laser ranging observations over a five-year interval. The results indicate that the mean rate of global plate motions for that interval are consistent with those averaged over several million years, and are not consistent with quiescent or greatly accelerated plate motions. This methodology was also

  20. Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study.

    Science.gov (United States)

    Ugwu, George O; Iyoke, Chukwuemeka A; Onah, Hyacinth E; Egwuatu, Vincent E; Ezugwu, Frank O

    2014-01-01

    Obstetricians in developing countries appear generally reluctant to conduct vaginal delivery in women with a previous Cesarean because of lack of adequate facilities for optimal fetomaternal monitoring. To describe delivery outcomes among women with one previous Cesarean section at a tertiary hospital in Southeast Nigeria. This was a prospective observational study to determine maternal and perinatal outcomes of attempted vaginal birth after Cesarean sections (VBAC) following one previous Cesarean section. Analysis was done with SPSS statistical software version 17.0 for Windows using descriptive and inferential statistics at 95% level of confidence. Two thousand six hundred and ten women delivered in the center during the study period, of whom 395 had one previous Cesarean section. A total of 370 women with one previous Cesarean section had nonrecurrent indications, of whom 355 consenting pregnant women with one previous Cesarean section were studied. A majority of the women (320/355, 90.1%) preferred to have vaginal delivery despite the one previous Cesarean section. However, only approximately 54% (190/355) were found suitable for trial of VBAC, out of whom 50% (95/190 had successful VBAC. Ninety-five women (50.0%) had failed attempt at VBAC and were delivered by emergency Cesarean section while 35 women (9.8%) had emergency Cesarean section for other obstetric indications (apart from failed VBAC). There was no case of uterine rupture or neonatal and maternal deaths recorded in any group. Apgar scores of less than 7 in the first minute were significantly more frequent amongst women who had vaginal delivery when compared to those who had elective repeat Cesarean section (P=0.03). Most women who had one previous Cesarean delivery chose to undergo trial of VBAC, although only about half were considered suitable for VBAC. The maternal and fetal outcomes of trial of VBAC in selected women with one previous Cesarean delivery for non-recurrent indications were good

  1. Encouraging Deep Approach to Learning in Civil and Geodetic Engineering

    Directory of Open Access Journals (Sweden)

    Gašper Mrak

    2016-10-01

    Full Text Available This paper presents activities and changes applied to the teaching process within selected courses offered by Faculty of civil and geodetic engineering, University of Ljubljana, Slovenia. Theoretical background, evaluated from the point of the technical education needs, is presented. It can be seen that special focus has to be made to the students' motivation for deep learning which guarantees optimal balance between acquisition of concepts and skills, information processing and integration of fragmented pieces of knowledge into complex structures. Three case studies used to test theoretical points of departure are presented. Results of the introduced novelties and changes have been evaluated through the assessment of knowledge, students' satisfaction and teaching staff evaluations. For conclusive results, monitoring over a longer period of time should be conducted.

  2. Treatment of osteochondral defects of the talus with a metal resurfacing inlay implant after failed previous surgery: a prospective study

    NARCIS (Netherlands)

    van Bergen, C. J. A.; van Eekeren, I. C. M.; Reilingh, M. L.; Sierevelt, I. N.; van Dijk, C. N.

    2013-01-01

    We have evaluated the clinical effectiveness of a metal resurfacing inlay implant for osteochondral defects of the medial talar dome after failed previous surgical treatment. We prospectively studied 20 consecutive patients with a mean age of 38 years (20 to 60), for a mean of three years (2 to 5)

  3. An fMRI study of neuronal activation in schizophrenia patients with and without previous cannabis use

    Directory of Open Access Journals (Sweden)

    Else-Marie eLøberg

    2012-10-01

    Full Text Available Previous studies have mostly shown positive effects of cannabis use on cognition in patients with schizophrenia, which could reflect lower neurocognitive vulnerability. There are however no studies comparing whether such cognitive differences have neuronal correlates. Thus, the aim of the present study was to compare whether patients with previous cannabis use differ in brain activation from patients who has never used cannabis. The patients groups were compared on the ability to up-regulate an effort mode network during a cognitive task and down-regulate activation in the same network during a task-absent condition. Task-present and task-absent brain activation was measured by functional magnetic resonance neuroimaging (fMRI. Twenty-six patients with a DSM-IV and ICD-10 diagnosis of schizophrenia were grouped into a previous cannabis user group and a no-cannabis group. An auditory dichotic listening task with instructions of attention focus on either the right or left ear stimulus was used to tap verbal processing, attention and cognitive control, calculated as an aggregate score. When comparing the two groups, there were remaining activations in the task-present condition for the cannabis group, not seen in the no-cannabis group, while there was remaining activation in the task-absent condition for the no-cannabis group, not seen in the cannabis group. Thus, the patients with previous cannabis use showed increased activation in an effort mode network and decreased activation in the default mode network as compared to the no-cannabis group. It is concluded that the present study show some differences in brain activation to a cognitively challenging task between previous cannabis and no-cannabis schizophrenia patients.

  4. Propagation of uncertainty by Monte Carlo simulations in case of basic geodetic computations

    Science.gov (United States)

    Wyszkowska, Patrycja

    2017-12-01

    The determination of the accuracy of functions of measured or adjusted values may be a problem in geodetic computations. The general law of covariance propagation or in case of the uncorrelated observations the propagation of variance (or the Gaussian formula) are commonly used for that purpose. That approach is theoretically justified for the linear functions. In case of the non-linear functions, the first-order Taylor series expansion is usually used but that solution is affected by the expansion error. The aim of the study is to determine the applicability of the general variance propagation law in case of the non-linear functions used in basic geodetic computations. The paper presents errors which are a result of negligence of the higher-order expressions and it determines the range of such simplification. The basis of that analysis is the comparison of the results obtained by the law of propagation of variance and the probabilistic approach, namely Monte Carlo simulations. Both methods are used to determine the accuracy of the following geodetic computations: the Cartesian coordinates of unknown point in the three-point resection problem, azimuths and distances of the Cartesian coordinates, height differences in the trigonometric and the geometric levelling. These simulations and the analysis of the results confirm the possibility of applying the general law of variance propagation in basic geodetic computations even if the functions are non-linear. The only condition is the accuracy of observations, which cannot be too low. Generally, this is not a problem with using present geodetic instruments.

  5. Integration of space geodesy: a US National Geodetic Observatory

    Science.gov (United States)

    Yunck, Thomas P.; Neilan, Ruth

    2003-01-01

    In the interest of improving the performance and efficiency of space geodesy a diverse group in the U.S., in collaboration with IGGOS, has begun to establish a unified National Geodetic Observatory (NGO).

  6. The University, the Market, and the Geodetic Engineer or

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2002-01-01

    of universities have changed profoundly, largely due to an increased emphasis on market norms. The changes within university teaching of geodetic engineers may be seen from the above perspective. Several fora for deliberations on the education exist, including the Commission 2 of the International Federation...... of Surveyors (FIG), and The European Council of Geodetic Surveyors. However, the paper takes its point of departure from the activities of the Joint European Project "Education in Land Information Systems", co-ordinated by Faculty of Geodetic Engineering, Delft University of Technology, and a subsequent...... project, which concerned the education of geodetic engineers in Slovenia. The body of the paper presents a selection of ideas that shaped the university through the centuries, with a view to balance the present interest in advancing market-directed behaviour....

  7. Geodetic Control Points - Multi-State Control Point Database

    Data.gov (United States)

    NSGIC State | GIS Inventory — The Multi-State Control Point Database (MCPD) is a database of geodetic and mapping control covering Idaho and Montana. The control were submitted by registered land...

  8. Changes in association between previous therapeutic abortion and preterm birth in Scotland, 1980 to 2008: a historical cohort study.

    Directory of Open Access Journals (Sweden)

    Clare Oliver-Williams

    Full Text Available Numerous studies have demonstrated that therapeutic termination of pregnancy (abortion is associated with an increased risk of subsequent preterm birth. However, the literature is inconsistent, and methods of abortion have changed dramatically over the last 30 years. We hypothesized that the association between previous abortion and the risk of preterm first birth changed in Scotland between 1 January 1980 and 31 December 2008.We studied linked Scottish national databases of births and perinatal deaths. We analysed the risk of preterm birth in relation to the number of previous abortions in 732,719 first births (≥24 wk, adjusting for maternal characteristics. The risk (adjusted odds ratio [95% CI] of preterm birth was modelled using logistic regression, and associations were expressed for a one-unit increase in the number of previous abortions. Previous abortion was associated with an increased risk of preterm birth (1.12 [1.09-1.16]. When analysed by year of delivery, the association was strongest in 1980-1983 (1.32 [1.21-1.43], progressively declined between 1984 and 1999, and was no longer apparent in 2000-2003 (0.98 [0.91-1.05] or 2004-2008 (1.02 [0.95-1.09]. A statistical test for interaction between previous abortion and year was highly statistically significant (p<0.001. Analysis of data for abortions among nulliparous women in Scotland 1992-2008 demonstrated that the proportion that were surgical without use of cervical pre-treatment decreased from 31% to 0.4%, and that the proportion of medical abortions increased from 18% to 68%.Previous abortion was a risk factor for spontaneous preterm birth in Scotland in the 1980s and 1990s, but the association progressively weakened and disappeared altogether by 2000. These changes were paralleled by increasing use of medical abortion and cervical pre-treatment prior to surgical abortion. Although it is plausible that the two trends were related, we could not test this directly as the data on

  9. Previous early antenatal service utilization improves timely booking: cross-sectional study at university of Gondar hospital, northwest Ethiopia.

    Science.gov (United States)

    Belayneh, Tadesse; Adefris, Mulat; Andargie, Gashaw

    2014-01-01

    Early booking of antenatal care (ANC) is regarded as a cornerstone of maternal and neonatal health care. However, existing evidence from developing countries indicate that lots of pregnant woman begin ANC booking lately. Objective. It was aimed to assess timing of ANC booking and associated factors among pregnant women attending ANC clinic at University of Gondar Hospital, 2013. An institution based cross-sectional study design was used to collect data with a face-to-face interview technique. Bivariate and multivariate analysis was used to identify associated factors for early ANC visit using SPSS version 20. From total women (N = 369) interviewed, 47.4% were timely booked. Mothers with younger age (AOR = 3.83, 95% CI: 1.89, 10.53), formal education (AOR = 1.06, 95% CI: 1.03, -7.61), previous early ANC visit (AOR = 2.39, 95% CI: 2.23, 9.86), and perceived ANC visit per pregnancy of four and greater were significantly associated with early ANC visit. Although late booking is a problem in this study, previous early utilization of ANC visit favors current timely booking. This indicates that the importance of early booking was appropriately addressed from previous visits. Counseling of timely booking during ANC visit should be strengthened. Moreover, empowering through education is also recommended.

  10. Effect of Acupressure, Acupuncture and Moxibustion in Women With Pregnancy-Related Anxiety and Previous Depression: A Preliminary Study.

    Science.gov (United States)

    Suzuki, Shunji; Tobe, Chiharu

    2017-06-01

    In this preliminary study, we examined the effect of acupressure, acupuncture and moxibustion (oriental treatments) to prevent of the relapse/deterioration of perinatal depression in women with pregnancy-related anxiety and previous depression. Between 2014 and 2016, there were 48 women with pregnancy-related anxiety and previous depression who had delivery at ≥ 22 weeks' gestation in our institute. Of these, oriental treatments were performed in eight and two women (totally 10, 21%) during pregnancy and postpartum, respectively. One of the 10 (10%) who received oriental treatments admitted depressive symptoms during pregnancy or postpartum, while 18 of the rest 38 who did not receive oriental treatments admitted depressive symptoms (47%, P = 0.065). The oriental treatments may be useful for pregnant women who need perinatal mental health care.

  11. [Cervical ripening after previous cesarean section with Foley catheter: A prospective study of 41 patients].

    Science.gov (United States)

    Lamourdedieu, C; Gnisci, A; Marcelli, M; Heckenroth, H; Gamerre, M; Agostini, A

    2015-05-01

    Effectiveness of cervical ripening with Foley catheter for patients requiring labor induction with a previous cesarean section and unfavorable cervical conditions. Prospective unicentric study conducted between 1 April 2011 and 31 October 2013 on 41 patients with medical indication for labor induction with a Bishop's scorecesarean section. Outcomes evaluated were mode of delivery, Bishop's score variations and maternal or neonatal complications. Cervical ripening was performed in 39 patients and 17 (43.5%) were delivered vaginally. A total of 24/39 (61.5%) patients were put into work and 10/39 (25.6%) came into work immediately after removal of the Foley catheter. The average score improvement Bishop was 2.7±0.6 points. No maternal or fetal complication was reported. Foley catheter is an interesting procedure in patients with previous cesarean section and unfavorable cervical conditions requiring labor induction. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  12. Tidal investigations at Borowa Gora Geodetic-Geophysical Observatory

    Science.gov (United States)

    Dykowski, Przemyslaw; Sekowski, Marcin

    2014-05-01

    In 2009 three LaCoste&Romberg model G gravimeters owed by the Institute of Geodesy and Cartography (IGiK) were equipped with a modern type of feedback system (LRFB-300) which gives a wide range of possibilities for gravimetric measurements. One of the modified LCR gravimeters (G1036) is used for continuous tidal recordings in Borowa Gora Geodetic - Geophysical Observatory of IGiK, is situated north of Warsaw. Good quality data is now collected from February of 2012. A set of Linux shell scripts have been developed to provide reliable readout recordings (via bluetooth) as well as automatic handling of any exceptional situations. The system runs with the LCR-G1036 from the beginning of February 2012, and since then the completeness of the recording visibly improved compared to previous recordings reaching nearly 98%. The tidal observation have been calibrated several times during the course of recordings, four times with the A10-020 and once with the FG5-230. Also some results concerning the calibration of the tidal recordings with relative meters is presented. A special period (end of 2013) is emphasized where the A10-020 performs measurements every hour for a two weeks alongside three LCR meters. The local tidal model is developed and presented with comparison to the model used in absolute gravity determinations with the A10-020 at Borowa Gora and on the stations of the gravity control.

  13. Previous experiences and emotional baggage as barriers to lifestyle change - a qualitative study of Norwegian Healthy Life Centre participants.

    Science.gov (United States)

    Følling, Ingrid S; Solbjør, Marit; Helvik, Anne-S

    2015-06-23

    Changing lifestyle is challenging and difficult. The Norwegian Directorate of Health recommends that all municipalities establish Healthy Life Centres targeted to people with lifestyle issues. Little is known about the background, experiences and reflections of participants. More information is needed about participants to shape effective lifestyle interventions with lasting effect. This study explores how participants in a lifestyle intervention programme describe previous life experiences in relation to changing lifestyle. Semi-structured qualitative in-depth interviews were performed with 23 participants (16 women and 7 men) aged 18 - 70 years. The data were analysed using systematic text condensation searching for issues describing participants' responses, and looking for the essence, aiming to share the basis of life-world experiences as valid knowledge. Participants identified two main themes: being stuck in old habits, and being burdened with emotional baggage from their previous negative experiences. Participants expressed a wish to change their lifestyles, but were unable to act in accordance with the health knowledge they possessed. Previous experiences with lifestyle change kept them from initiating attempts without professional assistance. Participants also described being burdened by an emotional baggage with problems from childhood and/or with family, work and social life issues. Respondents said that they felt that emotional baggage was an important explanation for why they were stuck in old habits and that conversely, being stuck in old habits added load to their already emotional baggage and made it heavier. Behavioural change can be hard to perform as psychological distress from life baggage can influence the ability to change. The study participants' experience of being stuck in old habits and having substantial emotional baggage raises questions as to whether or not Healthy Life Centres are able to help participants who need to make a lifestyle

  14. Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database.

    Directory of Open Access Journals (Sweden)

    Sarah J Stock

    Full Text Available There is evidence that induction of labour (IOL around term reduces perinatal mortality and caesarean delivery rates when compared to expectant management of pregnancy (allowing the pregnancy to continue to await spontaneous labour or definitive indication for delivery. However, it is not clear whether IOL in women with a previous caesarean section confers the same benefits. The aim of this study was to describe outcomes of IOL at 39-41 weeks in women with one previous caesarean delivery and to compare outcomes of IOL or planned caesarean delivery to those of expectant management.We performed a population-based retrospective cohort study of singleton births greater than 39 weeks gestation, in women with one previous caesarean delivery, in Scotland, UK 1981-2007 (n = 46,176. Outcomes included mode of delivery, perinatal mortality, neonatal unit admission, postpartum hemorrhage and uterine rupture. 40.1% (2,969/7,401 of women who underwent IOL 39-41 weeks were ultimately delivered by caesarean. When compared to expectant management IOL was associated with lower odds of caesarean delivery (adjusted odds ratio [AOR] after IOL at 39 weeks of 0.81 [95% CI 0.71-0.91]. There was no significant effect on the odds of perinatal mortality but greater odds of neonatal unit admission (AOR after IOL at 39 weeks of 1.29 [95% CI 1.08-1.55]. In contrast, when compared with expectant management, elective repeat caesarean delivery was associated with lower perinatal mortality (AOR after planned caesarean at 39 weeks of 0.23 [95% CI 0.07-0.75] and, depending on gestation, the same or lower neonatal unit admission (AOR after planned caesarean at 39 weeks of 0.98 [0.90-1.07] at 40 weeks of 1.08 [0.94-1.23] and at 41 weeks of 0.77 [0.60-1.00].A more liberal policy of IOL in women with previous caesarean delivery may reduce repeat caesarean delivery, but increases the risks of neonatal complications.

  15. What do formal inversions of space geodetic data tell us about fault slip rates? Examples from Southern California. (Invited)

    Science.gov (United States)

    Lindsey, E. O.; Fialko, Y.

    2010-12-01

    We use secular velocities from the continuous GPS data provided by the Plate Boundary Observatory (PBO) and Scripps Orbit Permanent Array Center (SOPAC), campaign GPS data (SCEC Crustal Motion Model) and InSAR data from the ERS-1/2 and ENVISAT satellites spanning nearly 20 years (1992-2010) to estimate the contemporaneous slip rates and locking depths on the Southern San Andreas fault (SAF), the San Jacinto fault (SJF) and the Elsinore fault. The model parameter space was interrogated using a Gibbs sampler, a Markov chain Monte Carlo algorithm which naturally approximates the joint probability distribution for the model parameters and allows for a formal evaluation of model uncertainties and trade-offs. We performed joint inversions of all available space geodetic data using the Savage and Burford (1973) dislocation model. Previous geodetic estimates of slip rates in this region based on dislocation models have generally inferred a higher slip velocity on the SAF (21-26 mm/yr), and a lower velocity on the SJF (12-19 mm/yr) (Becker et al. 2005, Fay and Humphreys 2005, Meade and Hager 2005, Fialko 2006). These "geodetic" slip rates are generally higher than geologic estimates representing average slip rates on time scales of 10^4-10^6 years. We investigate implications of fault geometry such as a non-vertical SAF and a "blind" segment of the SJF (Fialko 2006; Lin et al. 2007). Using the fault geometry motivated by these recent studies, we estimate a slip rate of 16(+/-2) mm/yr for the southern SAF, and a combined slip rate of 21(+/-3) mm/yr for the two closely spaced branches of the southern San Jacinto fault (the Coyote Creek fault and the blind southern continuation of the Clark fault). The locking depths are estimated at 7(+/-3) km and 14(+/-6) km for the SAF and SJF, respectively. For the SJF, we note a significant trade-off between fault velocity and locking depth, with the best-fitting values occurring at the lower end of the formally estimated parameter ranges

  16. Birth outcome in women with previously treated breast cancer--a population-based cohort study from Sweden.

    Directory of Open Access Journals (Sweden)

    Kristina Dalberg

    2006-09-01

    Full Text Available Data on birth outcome and offspring health after the appearance of breast cancer are limited. The aim of this study was to assess the risk of adverse birth outcomes in women previously treated for invasive breast cancer compared with the general population of mothers.Of all 2,870,932 singleton births registered in the Swedish Medical Birth Registry during 1973-2002, 331 first births following breast cancer surgery--with a mean time to pregnancy of 37 mo (range 7-163--were identified using linkage with the Swedish Cancer Registry. Logistic regression analysis was used. The estimates were adjusted for maternal age, parity, and year of delivery. Odds ratios (ORs and 95% confidence intervals (CIs were used to estimate infant health and mortality, delivery complications, the risk of preterm birth, and the rates of instrumental delivery and cesarean section. The large majority of births from women previously treated for breast cancer had no adverse events. However, births by women exposed to breast cancer were associated with an increased risk of delivery complications (OR 1.5, 95% CI 1.2-1.9, cesarean section (OR 1.3, 95% CI 1.0-1.7, very preterm birth (<32 wk (OR 3.2, 95% CI 1.7-6.0, and low birth weight (<1500 g (OR 2.9, 95% CI 1.4-5.8. A tendency towards an increased risk of malformations among the infants was seen especially in the later time period (1988-2002 (OR 2.1, 95% CI 1.2-3.7.It is reassuring that births overall were without adverse events, but our findings indicate that pregnancies in previously treated breast cancer patients should possibly be regarded as higher risk pregnancies, with consequences for their surveillance and management.

  17. On Comparing Precision Orbit Solutions of Geodetic Satellites Given Several Atmospheric Density Models

    Science.gov (United States)

    2014-08-01

    orbits the geodetic satellites LARETS, STARLETTE and STELLA . By comparing predictive orbits to fitted orbits for each satellite using a several...Table 1. Nominal Orbital Elements for STARLETTE Element Nominal Value Semi-major Axis 7, 190 km Eccentricity 0.0206 Inclination 49.83o STELLA CNES...Earth’s gravitational variations at different latitudes.17 STELLA is similarly well suited to study atmospheric drag effects. The nominal orbital

  18. STUDY OF INFLUENCE OF PREVIOUS ORAL APPLICATION OF DIPHTHERIA ANTIGENIC PREPARATIONS ON RABBIT ALLERGIC REACTION FORMING AFTER SKIN TEST

    Directory of Open Access Journals (Sweden)

    Babych YeM

    2013-03-01

    Full Text Available It’s studied an influence of previous oral application of diphtheria antigenic preparations on allergic inflammation forming after skin test. It’s used destroyed by ultrasonic microbe cells C.diphtheriae var. gravis tox+ massachusets, free from destroyed cells by the use of centrifugation supernatant and refined concentrated diphteria toxoid. Experimental rabbits are fed to 3,5 ml of one of antigenic preparations (the total protein dose is 33,6 mg, control ones are fed to saline. In a week all animals were injected intracutaneously 0,2 ml each of corresponding antigenic preparation. The findings testify to decreasing manifestation tendency of rabbit skin reactions on antigenic preparations.

  19. Studies on the immune response of previously infected lambs to vaccination with the radiation attenuated Dictyocaulus filaria vaccine

    International Nuclear Information System (INIS)

    Dhar, D.N.; Sharma, R.L.

    1976-01-01

    The immune response of lambs infected with the lungworm, Dictyocaulus filaria to vaccination with the radiation attenuated D.filaria vaccine was studied under experimental conditions. Healthy, un-infected lambs, 4-6 months of age were randomly distributed into three groups. Group one lambs were previously exposed to single or trickle infections of D.filaria before being vaccinated, group two lambs were vaccinated only whereas the group three lambs received neither infection nor were vaccinated. All the lambs were subsequently challanged with normal infective D.filaria larvae. The results of the experiment indicate that the vaccine confers very little or practically no immunity in lambs already exposed to the infection. The significance of these findings in the use of the vaccine for the control of lungworm disease in sheep under field conditions is discussed. (author)

  20. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, R. [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), Laboratorio de Analisis Quimico, Calle 30 no. 502, Playa, Ciudad Habana (Cuba)]. E-mail: roman.padilla@infomed.sld.cu; Espen, P. van [University of Antwerp (Belgium); Torres, P.P. Godo [Centro de Antropologia, Havana (Cuba)

    2006-02-03

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a {sup 241}Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery.

  1. Treatment satisfaction with paliperidone extended-release tablets: open-label study in schizophrenia patients dissatisfied with previous antipsychotic medication

    Directory of Open Access Journals (Sweden)

    Yang FD

    2017-04-01

    Full Text Available Fu De Yang,1 Juan Li,1 Yun Long Tan,1 Wei Ye Liang,1 Rongzhen Zhang,1 Ning Wang,1 Wei Feng,1 Shangli Cai,2 Jian Min Zhuo,2 Li Li Zhang2 1Beijing Hui-Long-Guan Hospital, 2Department of Medical Affairs, Xian Janssen Pharmaceutical Ltd, Beijing, People’s Republic of China Objective: The aim of this study was to evaluate the changes in treatment satisfaction after switching to paliperidone extended-release (ER in Chinese schizophrenia patients dissatisfied with their previous antipsychotic treatment.Methods: In this 8-week, open-label, single-arm, multicenter, prospective study, 1,693 patients dissatisfied with previous antipsychotic medication were enrolled and switched to paliperidone ER tablets (3–12 mg/d based on clinical judgment. The primary efficacy end point was change in Medication Satisfaction Questionnaire (MSQ score from baseline to week 8. The secondary end points included percentage of patients with MSQ score ≥4, as well as changes in Clinical Global Improvement-Severity (CGI-S and Personal and Social Performance (PSP scores.Results: MSQ scores increased significantly from baseline (mean [standard deviation {SD}]: 2.48 [0.55] to week 8 (5.47 [0.89], P<0.0001; primary end point, full analysis set. The percentage of patients with MSQ score ≥4 was 95.9% at week 8, indicating that most of the patients were satisfied with their treatment. Significant (P<0.0001 improvements from baseline to week 8 were noted in CGI-S score (2.37 [1.20] and PSP score (25.5 [15.0]. A total of 174 (10.28% patients experienced adverse events (AEs. The most common (>10 patients events were extrapyramidal disorder (n=84, 4.96%, poor quality sleep (n=18, 1.06% and akathisia (n=13, 0.77%. The majority of AEs were mild to moderate in severity. No deaths occurred.Conclusion: Treatment satisfaction improved after switching to paliperidone ER from the previous antipsychotic in Chinese patients with schizophrenia. Keywords: atypical antipsychotics, open label

  2. The Australian Geodetic Observing Program. Current Status and Future Plans

    Science.gov (United States)

    Johnston, G.; Dawson, J. H.

    2015-12-01

    Over the last decade, the Australian government has through programs like AuScope, the Asia Pacific Reference Frame (APREF), and the Pacific Sea Level Monitoring (PSLM) Project made a significant contribution to the Global Geodetic Observing Program. In addition to supporting the national research priorities, this contribution is justified by Australia's growing economic dependence on precise positioning to underpin efficient transportation, geospatial data management, and industrial automation (e.g., robotic mining and precision agriculture) and the consequent need for the government to guarantee provision of precise positioning products to the Australian community. It is also well recognised within Australia that there is an opportunity to exploit our near unique position as being one of the few regions in the world to see all new and emerging satellite navigation systems including Galileo (Europe), GPS III (USA), GLONASS (Russia), Beidou (China), QZSS (Japan) and IRNSS (India). It is in this context that the Australian geodetic program will build on earlier efforts and further develop its key geodetic capabilities. This will include the creation of an independent GNSS analysis capability that will enable Australia to contribute to the International GNSS Service (IGS) and an upgrade of key geodetic infrastructure including the national VLBI and GNSS arrays. This presentation will overview the significant geodetic activities undertaken by the Australian government and highlight its future plans.

  3. Evaluation of questionnaire-based information on previous physical work loads. Stockholm MUSIC 1 Study Group. Musculoskeletal Intervention Center.

    Science.gov (United States)

    Torgén, M; Winkel, J; Alfredsson, L; Kilbom, A

    1999-06-01

    The principal aim of the present study was to evaluate questionnaire-based information on past physical work loads (6-year recall). Effects of memory difficulties on reproducibility were evaluated for 82 subjects by comparing previously reported results on current work loads (test-retest procedure) with the same items recalled 6 years later. Validity was assessed by comparing self-reports in 1995, regarding work loads in 1989, with worksite measurements performed in 1989. Six-year reproducibility, calculated as weighted kappa coefficients (k(w)), varied between 0.36 and 0.86, with the highest values for proportion of the workday spent sitting and for perceived general exertion and the lowest values for trunk and neck flexion. The six-year reproducibility results were similar to previously reported test-retest results for these items; this finding indicates that memory difficulties was a minor problem. The validity of the questionnaire responses, expressed as rank correlations (r(s)) between the questionnaire responses and workplace measurements, varied between -0.16 and 0.78. The highest values were obtained for the items sitting and repetitive work, and the lowest and "unacceptable" values were for head rotation and neck flexion. Misclassification of exposure did not appear to be differential with regard to musculoskeletal symptom status, as judged by the calculated risk estimates. The validity of some of these self-administered questionnaire items appears sufficient for a crude assessment of physical work loads in the past in epidemiologic studies of the general population with predominantly low levels of exposure.

  4. Demonstration of the Cascadia G‐FAST geodetic earthquake early warning system for the Nisqually, Washington, earthquake

    Science.gov (United States)

    Crowell, Brendan; Schmidt, David; Bodin, Paul; Vidale, John; Gomberg, Joan S.; Hartog, Renate; Kress, Victor; Melbourne, Tim; Santillian, Marcelo; Minson, Sarah E.; Jamison, Dylan

    2016-01-01

    A prototype earthquake early warning (EEW) system is currently in development in the Pacific Northwest. We have taken a two‐stage approach to EEW: (1) detection and initial characterization using strong‐motion data with the Earthquake Alarm Systems (ElarmS) seismic early warning package and (2) the triggering of geodetic modeling modules using Global Navigation Satellite Systems data that help provide robust estimates of large‐magnitude earthquakes. In this article we demonstrate the performance of the latter, the Geodetic First Approximation of Size and Time (G‐FAST) geodetic early warning system, using simulated displacements for the 2001Mw 6.8 Nisqually earthquake. We test the timing and performance of the two G‐FAST source characterization modules, peak ground displacement scaling, and Centroid Moment Tensor‐driven finite‐fault‐slip modeling under ideal, latent, noisy, and incomplete data conditions. We show good agreement between source parameters computed by G‐FAST with previously published and postprocessed seismic and geodetic results for all test cases and modeling modules, and we discuss the challenges with integration into the U.S. Geological Survey’s ShakeAlert EEW system.

  5. The Impact of Sea Level Rise on Geodetic Vertical Datum of Peninsular Malaysia

    Science.gov (United States)

    Din, A. H. M.; Abazu, I. C.; Pa'suya, M. F.; Omar, K. M.; Hamid, A. I. A.

    2016-09-01

    Sea level rise is rapidly turning into major issues among our community and all levels of the government are working to develop responses to ensure these matters are given the uttermost attention in all facets of planning. It is more interesting to understand and investigate the present day sea level variation due its potential impact, particularly on our national geodetic vertical datum. To determine present day sea level variation, it is vital to consider both in-situ tide gauge and remote sensing measurements. This study presents an effort to quantify the sea level rise rate and magnitude over Peninsular Malaysia using tide gauge and multi-mission satellite altimeter. The time periods taken for both techniques are 32 years (from 1984 to 2015) for tidal data and 23 years (from 1993 to 2015) for altimetry data. Subsequently, the impact of sea level rise on Peninsular Malaysia Geodetic Vertical Datum (PMGVD) is evaluated in this study. the difference between MSL computed from 10 years (1984 - 1993) and 32 years (1984 - 2015) tidal data at Port Kelang showed that the increment of sea level is about 27mm. The computed magnitude showed an estimate of the long-term effect a change in MSL has on the geodetic vertical datum of Port Kelang tide gauge station. This will help give a new insight on the establishment of national geodetic vertical datum based on mean sea level data. Besides, this information can be used for a wide variety of climatic applications to study environmental issues related to flood and global warming in Malaysia.

  6. THE IMPACT OF SEA LEVEL RISE ON GEODETIC VERTICAL DATUM OF PENINSULAR MALAYSIA

    Directory of Open Access Journals (Sweden)

    A. H. M. Din

    2016-09-01

    Full Text Available Sea level rise is rapidly turning into major issues among our community and all levels of the government are working to develop responses to ensure these matters are given the uttermost attention in all facets of planning. It is more interesting to understand and investigate the present day sea level variation due its potential impact, particularly on our national geodetic vertical datum. To determine present day sea level variation, it is vital to consider both in-situ tide gauge and remote sensing measurements. This study presents an effort to quantify the sea level rise rate and magnitude over Peninsular Malaysia using tide gauge and multi-mission satellite altimeter. The time periods taken for both techniques are 32 years (from 1984 to 2015 for tidal data and 23 years (from 1993 to 2015 for altimetry data. Subsequently, the impact of sea level rise on Peninsular Malaysia Geodetic Vertical Datum (PMGVD is evaluated in this study. the difference between MSL computed from 10 years (1984 – 1993 and 32 years (1984 – 2015 tidal data at Port Kelang showed that the increment of sea level is about 27mm. The computed magnitude showed an estimate of the long-term effect a change in MSL has on the geodetic vertical datum of Port Kelang tide gauge station. This will help give a new insight on the establishment of national geodetic vertical datum based on mean sea level data. Besides, this information can be used for a wide variety of climatic applications to study environmental issues related to flood and global warming in Malaysia.

  7. A comprehensive study of oculocutaneous albinism type 1 reveals three previously unidentified alleles on the TYR gene.

    Science.gov (United States)

    Lin, Yu-Ying; Wei, Ai-Hua; He, Xin; Zhou, Zhi-Yong; Lian, Shi; Zhu, Wei

    2014-01-01

    Oculocutaneous albinism (OCA) is a congenital genetic disorder characterized by defects in melanin production. OCA type 1 (OCA1) is the most serious and common type of OCA. This study characterized mutations associated with OCA1 in a series of Chinese patients. We recruited 41 unrelated patients with OCA and 100 healthy subjects from the Chinese Han population. Genomic DNA was extracted from their blood samples. Mutational analysis of tyrosinase (TYR) genes was conducted using polymerase chain reaction (PCR) and direct sequencing, specifically to test the 100 control subjects and exclude the possibility of polymorphism. Mutational analysis and bioinformatics study were performed in TYR mutations. Among the 24 (58.5%) patients with OCA1, 21 different TYR mutations were identified, including three previously unidentified alleles (PUAs): one frameshift mutation (c.216delA) and two missense mutations (A241T and N364K). The proband mutation A241T carries three possible mutations in complex OCA. The findings of this study expand current knowledge and data of mutations associated with OCA1 in China and allow us to estimate or explore the mutation spectrum and relative frequencies of the TYR gene in the Chinese population.

  8. Barriers to postpartum screening for type 2 diabetes: a qualitative study of women with previous gestational diabetes.

    Science.gov (United States)

    Rafii, Forough; Rahimparvar, Seyedeh Fatemeh Vasegh; Mehrdad, Neda; Keramat, Afsaneh

    2017-01-01

    Risk of developing type 2 diabetes is increased in women with previous gestational diabetes mellitus (GDM). Postpartum glycemic screening is recommended in women with recent GDM. But this screening rate is low and the reasons are unclear. The aim of this study was to explore the experiences of Iranian women with recent GDM on barriers of postpartum screening for diabetes. This qualitative study was conducted in Tehran, Iran in 2016. Semi-structured interview was used for data collection. 22 women with recent GDM were interviewed. These women gave birth in Tehran hospitals at a minimum of 6 months before interview. The missed screening defined as not attending to laboratory for Fasting Blood Sugar and/or Oral Glucose Tolerance Test, 6 week to 6 month after their child birthing. The data was analyzed by content analysis method. Themes and sub-themes that illustrated the barriers to postpartum diabetes screening were: inadequate education (about developing diabetes in the future, implementation of the screening, and glucometer validity in diagnosis of diabetes), perceiving the screening as difficult (feeling comfortable with the glucometer, poor laboratory conditions, issues related to the baby/babies, and financial problems), improper attitudes toward the screening (unwilling to get diagnosed, not giving priority to oneself, having false beliefs) and procrastination (gap to intention and action, self-deception and self-regulation failure). Women with recent GDM reported several barriers for postpartum diabetes screening. This study help to develop the evidence-based interventions for improving this screening rate.

  9. Value and reliability of findings from previous epidemiologic studies in the assessment of radiation-related cancer risks. Pt. 3

    International Nuclear Information System (INIS)

    Frasch, G.; Martignoni, K.

    1990-01-01

    The theories put forward here are predominantly based on pooled data from previous studies in a number of cohorts made up by mostly non-average individuals. These studies were carried out by various researchers and differed in procedures and aims. Factors of major importance to the validity and reliability of the conclusions drawn from this study are pointed out. In one chapter some light is thrown on factors known to bear a relation to the incidence of radiation-induced cancer of the breast, even though at present this can only very vaguely be described on a quantitative basis. These factors include fractionated dose regimens, pregnancies and parturitions, menarche, menopause, synergisms as well as secondary cancer of the breast. The available body of evidence suggests that exposure of each of 1 million women to a dose of 10 mGy (rad) can be linked with approx. 3 additional cases of mammary cancer reported on an average per year after the latency period. The fact that there is some statistical scatter around this value is chiefly attributable to age-related causes at the beginning of exposure. Differences in ethnic and cultural characteristics between the populations investigated appeared to be less important here. (orig./MG) [de

  10. A Flexible-Dose Study of Paliperidone ER in Patients With Nonacute Schizophrenia Previously Treated Unsuccessfully With Oral Olanzapine

    Science.gov (United States)

    KOTLER, MOSHE; DILBAZ, NESRIN; ROSA, FERNANDA; PATERAKIS, PERIKLIS; MILANOVA, VIHRA; SMULEVICH, ANATOLY B.; LAHAYE, MARJOLEIN

    2016-01-01

    Objective: The goal of this study was to explore the tolerability, safety, and treatment response of switching from oral olanzapine to paliperidone extended release (ER). Methods: Adult patients with nonacute schizophrenia who had been treated unsuccessfully with oral olanzapine were switched to flexible doses of paliperidone ER (3 to 12 mg/d). The primary efficacy outcome was a ≥20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint for patients who switched medications because of lack of efficacy with olanzapine and noninferiority versus previous olanzapine treatment (mean endpoint change in PANSS total scores vs. baseline of ≤5 points) for patients who switched for reasons other than lack of efficacy. Safety and tolerability were assessed by monitoring adverse events, extrapyramidal symptoms, and weight change. Results: Of 396 patients, 65.2% were men, mean age was 40.0±12.0 years, and 75.5% had paranoid schizophrenia. Among the patients whose main reason for switching was lack of efficacy, an improvement in the PANSS total score of ≥20% occurred in 57.4% of patients. Noninferiority was confirmed for each subgroup of patients whose main reason for switching was something other than lack of efficacy. Paliperidone ER was generally well tolerated. Extrapyramidal symptoms as measured by total Extrapyramidal Symptom Rating Scale scores showed statistically significant and clinically relevant improvements at endpoint, the average weight decreased by 0.8±5.2 kg at endpoint, and a clinically relevant weight gain of ≥7% occurred in 8.0% of patients. Conclusion: Paliperidone ER flexibly-dosed over 6 months was well tolerated and associated with a meaningful clinical response in patients with nonacute schizophrenia who had previously been unsuccessfully treated with oral olanzapine. PMID:26813484

  11. A Flexible-Dose Study of Paliperidone ER in Patients With Nonacute Schizophrenia Previously Treated Unsuccessfully With Oral Olanzapine.

    Science.gov (United States)

    Kotler, Moshe; Dilbaz, Nesrin; Rosa, Fernanda; Paterakis, Periklis; Milanova, Vihra; Smulevich, Anatoly B; Lahaye, Marjolein; Schreiner, Andreas

    2016-01-01

    The goal of this study was to explore the tolerability, safety, and treatment response of switching from oral olanzapine to paliperidone extended release (ER). Adult patients with nonacute schizophrenia who had been treated unsuccessfully with oral olanzapine were switched to flexible doses of paliperidone ER (3 to 12 mg/d). The primary efficacy outcome was a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint for patients who switched medications because of lack of efficacy with olanzapine and noninferiority versus previous olanzapine treatment (mean endpoint change in PANSS total scores vs. baseline of ≤ 5 points) for patients who switched for reasons other than lack of efficacy. Safety and tolerability were assessed by monitoring adverse events, extrapyramidal symptoms, and weight change. Of 396 patients, 65.2% were men, mean age was 40.0 ± 12.0 years, and 75.5% had paranoid schizophrenia. Among the patients whose main reason for switching was lack of efficacy, an improvement in the PANSS total score of ≥ 20% occurred in 57.4% of patients. Noninferiority was confirmed for each subgroup of patients whose main reason for switching was something other than lack of efficacy. Paliperidone ER was generally well tolerated. Extrapyramidal symptoms as measured by total Extrapyramidal Symptom Rating Scale scores showed statistically significant and clinically relevant improvements at endpoint, the average weight decreased by 0.8 ± 5.2 kg at endpoint, and a clinically relevant weight gain of ≥ 7% occurred in 8.0% of patients. Paliperidone ER flexibly-dosed over 6 months was well tolerated and associated with a meaningful clinical response in patients with nonacute schizophrenia who had previously been unsuccessfully treated with oral olanzapine.

  12. Recent Geodetic Activities of the Shanghai VLBI Correlator

    Science.gov (United States)

    Jiang, Wu; Shu, Fengchun; Tong, Fengxian; Zheng, Weimin

    2014-12-01

    Recent geodetic activities concerning the Shanghai VLBI Correlator are reported in this paper. A more accurate delay model was implemented in the domestic correlator job generating software, which has been used for the VLBI sessions for tracking satellites and the Chinese domestic geodetic VLBI program. The comparison results of model delays with Calc9.0 will be shown. We also managed to develop an offline software function to convert the correlator output into FITS-IDI format. Furthermore, we obtained some experience in processing a few geodetic sessions with an ad hoc DiFX correlator and the HOPS software, the final results were very promising. A new hardware cluster dedicated to DiFX was constructed. It will expand to a platform of more than 300 cores, 300TB RAID, and eight Mark 5 units by 2014.

  13. VLBI2010 PROOF-OF-CONCEPT GEODETIC VLBI SYSTEM

    Science.gov (United States)

    Beaudoin, C.; Niell, A. E.

    2009-12-01

    Geodetic Very Long Baseline Interferometry (VLBI) plays an important role in establishing the Terrestrial Reference Frame, measuring the Earth-orientation parameters (EOP), and understanding the properties of the Inner Core, among other geophysical phenomena. To enhance the science obtained from geodetic VLBI, NASA is funding the development of a new broadband geodetic VLBI microwave (2-12 GHz) system by the MIT Haystack Observatory, in cooperation with personnel from HTSI, NVI, and GSFC. This broadband system is intended to replace the operational S/X-band system currently deployed in the global geodetic VLBI network. The broadband capability of the new feed and receiver and the sustained data recording rate (up to 4 Gbps per band) supported by the digital back-end and Mark5C recorder will a) allow the use of relatively small (~12m) but fast slewing antennas to reduce the error due to atmosphere delay fluctuations and b) provide flexibility in frequency coverage to reduce sensitivity to external radio frequency interference, an increasing problem. A demonstration system has been implemented by installing the proof-of-concept feed, receiver, and data acquisition system on the single baseline composed of the 18m antenna in Westford MA and the 5m MV3 antenna at the Goddard Space Flight Center in Greenbelt MD. In our contribution we will describe the new geodetic VLBI system and discuss recent results. Future challenges and advances that will be needed in both hardware and software to achieve the required precision of the geodetic observables will also be presented.

  14. Patterns and Determinants of Treatment Seeking among Previously Untreated Psychotic Patients in Aceh Province, Indonesia: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Marthoenis Marthoenis

    2016-01-01

    Full Text Available Immediate treatment of first-episode psychosis is essential in order to achieve a positive outcome. However, Indonesian psychiatric patients often delay accessing health services, the reason for which is not yet fully understood. The current study aimed to understand patterns of treatment seeking and to reveal determinants of the delay in accessing psychiatric care among first-time user psychotic patients. Qualitative interviews were conducted with sixteen family members who accompanied the patients to a psychiatric hospital. Many families expressed beliefs that mental illness appertains to village sickness and not hospital sickness; therefore, they usually take the patients to traditional or religious healers before taking them to a health professional. They also identified various factors that potentially delay accessing psychiatric treatment: low literacy and beliefs about the cause of the illness, stigmatisation, the role of extended family, financial problems, and long distance to the psychiatric hospital. On the other hand, the family mentioned various factors related to timely help seeking, including being a well-educated family, living closer to health facilities, previous experience of successful psychotic therapy, and having more positive symptoms of psychosis. The findings call for mental health awareness campaigns in the community.

  15. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  16. Using a pregnancy decision support program for women choosing birth after a previous caesarean in Japan: A mixed methods study.

    Science.gov (United States)

    Torigoe, Ikuyo; Shorten, Allison

    2018-02-01

    Opportunities for women and providers to use decision aids and share decisions about birth after caesarean in practice are currently limited in Japan. This is despite known benefits of decision aids to support value-sensitive healthcare decisions. To explore Japanese women's decision making experiences using a decision aid program for birth choices after caesarean. A mixed methods study was conducted among 33 consenting pregnant women with previous caesarean in five obstetrics institutions located in the western part of Japan. Outcome measures included change in level of decisional conflict, change in knowledge, and preference for birth method. Semi-structured interviews examined women's decision making experiences, and qualitative data were analyzed using thematic analysis. The participants in the program experienced a statistically significant improvement in knowledge and reduction in decisional conflict about birth after caesarean. Four themes were identified in the qualitative data related to decision making: change in women's knowledge about birth choices, clarifying women's birth preference, feelings about shared decision making, and contrasting feelings after receiving information. This study confirmed potential benefits of using the decision aid program. However, uncertainty about mode of birth continued for some women immediately prior to the birth. This finding emphasized the need to identify additional ways to support women emotionally throughout the process of decision making about birth after caesarean. It was feasible to adapt the decision aid for use in clinical practice. Future research is necessary to examine its effectiveness when implemented in Japanese clinical settings. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  17. An algorithm for determination of geodetic path for application in long-range acoustic propagation

    Digital Repository Service at National Institute of Oceanography (India)

    Murty, T.V.R.; Sivakholundu, K.M.; Navelkar, G.S.; Somayajulu, Y.K.; Murty, C.S.

    A computer program has been developed for the construction of geodetic path between two points on the spheroidal surface for application in long range acoustic propagation in the ocean. Geodetic equations have integrated numerically upto...

  18. Discovery of previously undetected intellectual disability by psychological assessment: a study of consecutively referred child and adolescent psychiatric inpatients.

    Science.gov (United States)

    Pogge, David L; Stokes, John; Buccolo, Martin L; Pappalardo, Stephen; Harvey, Philip D

    2014-07-01

    Intellectual disability is associated with an increased risk of behavioral disturbances and also complicates their treatment. Despite increases in the sophistication of medical detection of early risk for intellectual disability, there is remarkably little data about the detection of intellectual disability in cases referred for psychiatric treatment. In this study, we used a 10-year sample of 23,629 consecutive child and adolescent admissions (ages between 6 and 17) to inpatient psychiatric treatment. Eleven percent (n=2621) of these cases were referred for psychological assessment and were examined with a general measure of intellectual functioning (i.e., WISC-IV). Of these cases, 16% had Full Scale IQs below 70. Of the cases whose therapists then referred them for formal assessment of their adaptive functioning (i.e., ABAS-II) 81% were found to have composite scores below 70 as well. Only one of the cases whose Full Scale IQ was less than 70 had a referral diagnosis of intellectual disability. Cases with previously undetected intellectual disability were found to be significantly more likely to have a diagnosis of a psychotic disorder and less likely to have a diagnosis of mood disorder than cases with IQs over 70. Disruptive behavior disorder diagnoses did not differ as a function of intellectual performance. These data suggest a high rate of undetected intellectual disability in cases with a psychiatric condition serious enough to require hospitalization and this raises the possibility that many such cases may be misdiagnosed, the basis of their problems may be misconceptualized, and they may be receiving treatments that do not take into account their intellectual level. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Associations of obesity with newly diagnosed and previously known atopic diseases in Chinese adults: a case-control study

    OpenAIRE

    Xie, Biao; Wang, Zhiqiang; Wang, Yupeng; Liu, Meina; Wang, Yongchen

    2017-01-01

    To assess the associations of obesity with newly diagnosed and previously known atopic disorders in Chinese adults. 4,629 adults aged 18 years or older were recruited in Harbin, China. Among them, 1,114 were previously diagnosed atopic cases, 1,298 were newly diagnosed cases, and 2,217 non-atopic controls. Obesity and overweight are defined according to the criteria established by the Working Group on Obesity in China. The associations of obesity with known and newly diagnosed atopic disorder...

  20. Organizing the Global Geodetic Observing System - Structure, Services and Stakeholders

    Science.gov (United States)

    Kutterer, Hansjoerg

    2017-04-01

    The Global Geodetic Observing System (GGOS) is an essential component of the International Association of Geodesy (IAG). It aims at advancing our understanding of the dynamic Earth system by quantifying our planet's changes in space and time. This is based on the mission of GGOS: (1) to provide the observations needed to monitor, map, and understand changes in the Earth's shape, rotation, and mass distribution, (2) to provide the global geodetic frame of reference that is the fundamental backbone for measuring and consistently interpreting key global change processes and for many other scientific and societal applications, and (3) to benefit science and society by providing the foundation upon which advances in Earth and planetary system science and applications are built. For this purpose GGOS works with the IAG components to provide the geodetic infrastructure which is necessary for monitoring the Earth system and for global change research. Obviously, this is a cross-cutting issue both of IAG regarding its commissions, services and inter-comission committees and of external stakeholders. Hence, the structure and the activities of GGOS have to deal with various facets of the establishment, maintenance, operation and further development geodetic observation and data infrastructure such as networks, hardware, standards and products. This presentation gives a general overview of the present state of GGOS. In particular, it focuses on the structure of GGOS which is optimized and streamlined regarding role and purpose of GGOS. Moreover, it outlines feasible results of GGOS for the benefit of IAG and of society.

  1. Verification of Positional Accuracy of ZVS3003 Geodetic Control ...

    African Journals Online (AJOL)

    The International GPS Service (IGS) has provided GPS orbit products to the scientific community with increased precision and timeliness. Many users interested in geodetic positioning have adopted the IGS precise orbits to achieve centimeter level accuracy and ensure long-term reference frame stability. Positioning with ...

  2. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  3. Geodetic constraints on frictional properties of the Imperial fault, Southern California

    Science.gov (United States)

    Lindsey, E. O.; Fialko, Y. A.

    2015-12-01

    We analyze a suite of geodetic observations across the Imperial fault in Southern California that span the complete earthquake cycle. We record interseismic deformation using four separate ENVISAT InSAR viewing geometries and continuous and survey-mode GPS, resulting in a dense set of observations of both shallow creep and regional strain accumulation due to secular loading. These data are combined with observations of coseismic and postseismic surface slip due to the 1979 Mw 6.6 Imperial Valley earthquake. We compare the geodetic data to two-dimensional models of the earthquake cycle on a strike-slip fault obeying rate- and state-dependent friction. We find that data from all parts of the earthquake cycle are required to constrain key fault properties such as the rate-dependence parameter (a-b) as a function of depth; the extent of shallow creep; and the recurrence interval of large events. The data are inconsistent with a high (>30 mm/yr) slip rate on the Imperial fault, and we propose that an extension of the San Jacinto - Superstition Hills fault system through the town of El Centro may accommodate a significant portion of the slip previously attributed to the Imperial fault. Models including this additional sub-parallel fault are in better agreement with the available observations, implying that the long-term slip rate of the Imperial fault is lower than previously suggested, and that there may be a significant unmapped hazard in the western Imperial Valley.

  4. Associations of obesity with newly diagnosed and previously known atopic diseases in Chinese adults: a case-control study.

    Science.gov (United States)

    Xie, Biao; Wang, Zhiqiang; Wang, Yupeng; Liu, Meina; Wang, Yongchen

    2017-03-02

    To assess the associations of obesity with newly diagnosed and previously known atopic disorders in Chinese adults. 4,629 adults aged 18 years or older were recruited in Harbin, China. Among them, 1,114 were previously diagnosed atopic cases, 1,298 were newly diagnosed cases, and 2,217 non-atopic controls. Obesity and overweight are defined according to the criteria established by the Working Group on Obesity in China. The associations of obesity with known and newly diagnosed atopic disorders were assessed using logistic regressions. Obesity was significantly associated with known atopic disorders (adjusted OR = 2.41 (95% CI: 1.81, 3.22)). The association of obesity with newly diagnosed atopic cases was not as strong as that with known cases, and was not statistically significant (adjusted OR = 1.27 (95% CI: 0.94, 1.72)). The similar pattern was observed in different allergic diseases, gender and age stratifications. The association between overweight and atopic diseases were not significant. Obesity is strongly associated with previously diagnosed atopic cases but not so with newly diagnosed atopic cases in Chinese adults. It is likely that people with atopic disorders have a higher risk of developing obesity. Our findings are important for the management of atopic disorders and chronic disease prevention among atopic disease patients.

  5. Radioimmunotherapy with Y-90-epratuzumab in patients with previously treated B-cell lymphoma. A fractionated dose-escalation study

    International Nuclear Information System (INIS)

    Linden, O.; Cavallin-Stahl, E.; Tennvall, J.; Hindorf, C.; Olsson, T.; Strand, S.E.; Stenberg, L.; Wingardh, K.

    2002-01-01

    Aim: Fractionated RIT may improve outcome by decreasing heterogeneity in absorbed dose and by increasing therapeutic window. The humanised anti-CD22 antibody, Epratuzumab, (Immunomedics, Inc., Morris Plains, NJ) can be given repeatedly with minimal risk of neutralising Ab (HAHA), making fractionated treatment with 90 Y-labelled epratuzumab possible. Materials and Methods: Patients with previously treated B-cell lymphoma received increasing number (2-4) of weekly infusions of 90 Y-epratuzumab. Patients received either 185 MBq/m 2 per infusion (group A), or, if they had a history of high-dose chemotherapy with stem-cell rescue, 92.5 MBq/m 2 per infusion (group B). The first infusion included 150 MBq of 111 Indium for scintigraphic verification of tumour targeting and dosimetry. 1.5 mg/kg epratuzumab was administered with each infusion. The treatment could be repeated once after 3 m. Results: Of 23 patients, 16 in group A and 6 in group B were evaluable for response. The RR in group A was 62% objective response (OR) and 25% CR/CRu. One patient in group B showed OR. OR was seen in aggressive and indolent lymphoma. Response was also long-lasting and event-free survival of patients showing CR/CRu was 14 to 25+ months. In group A all seven patient, receiving three infusions, showed less than grade 3 platelet and neutrophil toxicity, except for two patients suffering grade 3 neutropenia. Of five patients with 4 weekly infusions there were two patients with dose-limiting haematological toxicity (DLT), both recently treated with high dose cytosar before RIT. With criteria used the maximal tolerated dose was three infusions 185 MBq/m 2 . In group B no patient suffered DLT and one patient exhibited OR. Seven patients were retreated after 3 months with minor toxicity, but improvement in OR in two cases. No patient has developed HAHA. CD22 expression on tumour cells, as assessed by flow cytometry, is available in 18 of 22 patients. In group A, seven of eight patients with

  6. Progresses and Prospects in Developing Marine Geodetic Datum and Marine Navigation of China

    Directory of Open Access Journals (Sweden)

    YANG Yuanxi

    2017-01-01

    Full Text Available Territorial water is a significant part of national sovereignty of China, thus the infrastructures of national space datum and location services should not only cover the land areas, but also the sea areas. China has established relatively complete geodetic datum in land areas over the past decades, including the new developed China Geodetic Coordinate System 2000 (CGCS 2000 and the national gravity datum 2000. However, the currently used geodetic infrastructures have not well covered the sea areas of China. The marine geodetic datum and marine navigation technologies need to be further developed and extended to satisfy the national demands of marine defense and marine economy development in new era of China. This paper mainly reviews the developing states and progress of Chinese marine geodetic datum and marine navigation, analyses key technologies in establishing the national marine geodetic datum. The develop current trends and future directions for the national marine geodetic datum and marine navigation technologies are listed.

  7. Spatiotemporal Relationship between Geodetic and Seismic Quantities: A Possible Clue to Preparatory Processes of M ≥ 6.0 Inland Earthquakes in Japan

    Directory of Open Access Journals (Sweden)

    Masashi Kawamura

    2012-01-01

    Full Text Available Constructing a statistical model to characterize the physical conditions associated with large earthquake occurrence is crucial for disaster mitigation. With the aim to formulate such a model, we previously developed a statistical evaluation system which assesses the correlation of the spatiotemporal relationship between different kinds of physical quantities with the occurrence times of large inland earthquakes. In this study, we focused on assessing the relationship between geodetic and seismic quantities and attempted to find the pair of related quantities that most likely indicates preparatory processes of large earthquakes in Japan. We assessed the quantities prior to M ≥ 6.0 inland earthquakes for the period of 2001–2007 in terms of probability gains and error diagram. Our system revealed that the pair of absolute value of dilatation rate and seismic energy showed the highest statistical performance. Further validation of this result is required by updating the database of physical quantities.

  8. First Geodetic Results from the Australasian VLBI Network

    Science.gov (United States)

    Titov, Oleg; Lovell, Jim; Takeguchi, Hiroshi; Quick, Jonathan; Shabala, Stanislav; McCallum, Jamie; Sun, Jing; Dawson, John; de Witt, Aletha; Reynolds, Cormac; Bignall, Hayley; Natusch, Tim; Weston, Stuart; Gulyaev, Sergei

    2014-12-01

    The Australasian geodetic Very Long Baseline Interferometry (VLBI) array consisting of three new 12-meter radio telescopes in Australia (Hobart, Katherine, and Yarragadee), a 12-meter radio telescope in New Zealand (Warkworth), and a correlation facility in Perth started operations in 2011. The daily positions of the AuScope array are estimated with a precision of a few mm, whereas their daily estimates vary within a range of 20-30 mm on the annual scale. Analysis of geodetic VLBI sessions also reveals small linear trends in the time series of baseline lengths between the Australian and New Zealand stations. A seasonal signal with amplitude of about 10 mm was detected for the baseline Hobart-Katherine. This signal is consistent with seasonal variations of baselines between co-located GNSS stations. We argue this signal should be incorporated in the fitting model to improve the estimates of positions and linear velocities.

  9. Evaluation of a rapid dipstick (Crystal VC for the diagnosis of cholera in Zanzibar and a comparison with previous studies.

    Directory of Open Access Journals (Sweden)

    Benedikt Ley

    Full Text Available The gold standard for the diagnosis of cholera is stool culture, but this requires laboratory facilities and takes at least 24 hours. A rapid diagnostic test (RDT that can be used by minimally trained staff at treatment centers could potentially improve the reporting and management of cholera outbreaks.We evaluated the Crystal VC™ RDT under field conditions in Zanzibar in 2009. Patients presenting to treatment centers with watery diarrhea provided a stool sample for rapid diagnostic testing. Results were compared to stool culture performed in a reference laboratory. We assessed the overall performance of the RDT and evaluated whether previous intake of antibiotics, intravenous fluids, location of testing, and skill level of the technician affected the RDT results.We included stool samples from 624 patients. Compared to culture, the overall sensitivity of the RDT was 93.1% (95%CI: 88.7 to 96.2%, specificity was 49.2% (95%CI: 44.3 to 54.1%, the positive predictive value was 47.0% (95%CI: 42.1 to 52.0% and the negative predictive value was 93.6% (95%CI: 89.6 to 96.5%. The overall false positivity rate was 50.8% (213/419; fieldworkers frequently misread very faint test lines as positive.The observed sensitivity of the Crystal VC RDT evaluated was similar compared to earlier versions, while specificity was poorer. The current version of the RDT could potentially be used as a screening tool in the field. Because of the high proportion of false positive results when field workers test stool specimens, positive results will need to be confirmed with stool culture.

  10. TREATMENT OF GEODETIC SURVEY DATA AS FUZZY VECTORS

    OpenAIRE

    G. Navratil; E. Heer; J. Hahn

    2015-01-01

    Geodetic survey data are typically analysed using the assumption that measurement errors can be modelled as noise. The least squares method models noise with the normal distribution and is based on the assumption that it selects measurements with the highest probability value (Ghilani, 2010, p. 179f). There are environment situations where no clear maximum for a measurement can be detected. This can happen, for example, if surveys take place in foggy conditions causing diffusion of l...

  11. Ray-traced Delays in the Atmosphere for Geodetic VLBI

    Science.gov (United States)

    Hofmeister, Armin; Böhm, Johannes

    2014-12-01

    The application of ray-traced slant path delays has the potential to enhance geodetic Very Long Baseline Interferometry (VLBI) analysis through improving the correction of the tropospheric effects on the observations. The utilization of directly estimated ray-traced slant path delays calculated from true meteorological data has the potential to overcome the shortcomings of the commonly used method of indirectly determined slant path delays via zenith delays mapped to the actual observation angle. Within our project RADIATE VLBI (Ray-traced Delays in the Atmosphere for geodetic VLBI) we are developing a new ray-tracing program for application in geodetic VLBI analysis. We introduce our project and present an overview of the current development status of our ray-tracer. In order to verify our results, we compare our ray-traced delays to results of a ray-tracer comparison campaign by Nafisi et al. (2012b), te{bib_Nafisi_2012b}. The RADIATE piecewise-linear solution for the slant total delay calculated from mapping factors at 5(°) elevation agrees with most of the other ray-tracers, with mean differences below 1 cm and standard deviations below 0.6 cm at the station Tsukuba and mean differences below 2.5 cm and standard deviations below 1 cm at the station Wettzell.

  12. Datum maintenance of the main Egyptian geodetic control networks by utilizing Precise Point Positioning "PPP" technique

    Science.gov (United States)

    Rabah, Mostafa; Elmewafey, Mahmoud; Farahan, Magda H.

    2016-06-01

    A geodetic control network is the wire-frame or the skeleton on which continuous and consistent mapping, Geographic Information Systems (GIS), and surveys are based. Traditionally, geodetic control points are established as permanent physical monuments placed in the ground and precisely marked, located, and documented. With the development of satellite surveying methods and their availability and high degree of accuracy, a geodetic control network could be established by using GNSS and referred to an international terrestrial reference frame used as a three-dimensional geocentric reference system for a country. Based on this concept, in 1992, the Egypt Survey Authority (ESA) established two networks, namely High Accuracy Reference Network (HARN) and the National Agricultural Cadastral Network (NACN). To transfer the International Terrestrial Reference Frame to the HARN, the HARN was connected with four IGS stations. The processing results were 1:10,000,000 (Order A) for HARN and 1:1,000,000 (Order B) for NACN relative network accuracy standard between stations defined in ITRF1994 Epoch1996. Since 1996, ESA did not perform any updating or maintaining works for these networks. To see how non-performing maintenance degrading the values of the HARN and NACN, the available HARN and NACN stations in the Nile Delta were observed. The Processing of the tested part was done by CSRS-PPP Service based on utilizing Precise Point Positioning "PPP" and Trimble Business Center "TBC". The study shows the feasibility of Precise Point Positioning in updating the absolute positioning of the HARN network and its role in updating the reference frame (ITRF). The study also confirmed the necessity of the absent role of datum maintenance of Egypt networks.

  13. PREVIOUS SECOND TRIMESTER ABORTION

    African Journals Online (AJOL)

    PNLC

    PREVIOUS SECOND TRIMESTER ABORTION: A risk factor for third trimester uterine rupture in three ... for accurate diagnosis of uterine rupture. KEY WORDS: Induced second trimester abortion - Previous uterine surgery - Uterine rupture. ..... scarred uterus during second trimester misoprostol- induced labour for a missed ...

  14. Regional Crustal Deformation and Lithosphere Thickness Observed with Geodetic Techniques

    Science.gov (United States)

    Vermeer, M.; Poutanen, M.; Kollo, K.; Koivula, H.; Ahola, J.

    2009-04-01

    The solid Earth, including the lithosphere, interacts in many ways with other components of the Earth system, oceans, atmosphere and climate. Geodesy is a key provider of data needed for global and environmental research. Geodesy provides methods and accurate measurements of contemporary deformation, sea level and gravity change. The importance of the decades-long stability and availability of reference frames must be stressed for such studies. In the future, the need to accurately monitor 3-D crustal motions will grow, both together with increasingly precise GNSS (Global Navigation Satellite System) positioning, demands for better follow-up of global change, and local needs for crustal motions, especially in coastal areas. These demands cannot yet be satisfied. The project described here is a part of a larger entity: Upper Mantle Dynamics and Quaternary Climate in Cratonic Areas, DynaQlim, an International Lithosphere Project (ILP) -sponsored initiative. The aims of DynaQlim are to understand the relations between upper mantle dynamics, mantle composition, physical properties, temperature and rheology, to study the postglacial uplift and ice thickness models, sea level change and isostatic response, Quaternary climate variations and Weichselian (Laurentian and other) glaciations during the late Quaternary. We aim at studying various aspects of lithospheric motion within the Finnish and Fennoscandian area, but within a global perspective, by the newest geodetic techniques in a multidisciplinary setting. The studies involve observations of three-dimensional motions and gravity change in a multidisciplinary context on a range of spatial scales: the whole of Fennoscandia, Finland, a regional test area of Satakunta, and the local test site Olkiluoto. Objectives of the research include improving our insight into the 3-D motion of a thick lithosphere, and into the gravity effect of the uplift, using novel approaches; improving the kinematic 3-D models in the

  15. The 2015, Mw 6.5, Leucas (Ionian Sea, Greece) earthquake: Seismological and Geodetic Modelling

    Science.gov (United States)

    Saltogianni, Vasso; Taymaz, Tuncay; Yolsal-Çevikbilen, Seda; Eken, Tuna; Moschas, Fanis; Stiros, Stathis

    2016-04-01

    A cluster of earthquakes (6Lefkada) earthquake. The modelling of these earthquakes, some of which are double events (2003 Leucas; 2014 Cephalonia) is a challenge for two main reasons. First, the geography of the area limits the distribution of the available seismological and GNSS stations and the correlations of INSAR data. Second, the structural pattern of the area indicates distributed thrusting but recent earthquakes are confined to the west margin of the Aegean Arc, usually assigned to the Cephalonia Transform Fault (CTF), and are dominated by strike slip faulting. In order to contribute to the understanding active tectonics along this critical region, our study was based on the independent analysis of the seismological and geodetic signature of the 2015 earthquake and the on the joint evaluation of the inferred models on the basis of the fault pattern of the area and of previous earthquakes. First, based on teleseismic long-period P- and SH- and broad-band P-waveforms a point-source solution at the SW part of Leucas yielded dominantly right-lateral strike-slip faulting mechanisms (strike: 23o, dip: 68o, rake: -170o) with a shallow focal depth (h: 9 km) and with seismic moment of Mo: 10.4x1018 Nm. Furthermore, the rupture history of the earthquake was obtained by applying a new back-projection method that uses teleseismic P-waveforms to integrate the direct P-phase with reflected phases from structural discontinuities near the source. In the slip inversion the faulting occurs on a single fault plane (strike and dip are obtained from the best fitting point-source solution) and slip (rake) angle varied during the whole rupture process. Second, co-seismic displacements were derived from eight permanent and one campaign GPS stations spread in the near and far field of the meizoseismal area. Significant horizontal slip was recognized, with a maximum dislocation of 36 cm in the SW part of Leucas island. Inversion of GPS-derived displacements using the new TOPological

  16. Studies in iodine metabolism: 33 year summary, 1948-1979 (as previously submitted) with appendix, 1979-1982

    International Nuclear Information System (INIS)

    Middlesworth, L.V.

    1982-01-01

    The results of research into iodine metabolism from 1948 to 1982 are summarized. Study areas included the monitoring of iodine 131 from fallout in the thyroid glands of cattle and humans, the biological functions and metabolism of thyroid hormones, and methods to reduce the retention of radioiodine in the thyroid

  17. Fever-Induced Brugada Syndrome Is More Common Than Previously Suspected: A Cross-Sectional Study from an Endemic Area.

    Science.gov (United States)

    Rattanawong, Pattara; Vutthikraivit, Wasawat; Charoensri, Attawit; Jongraksak, Tanawat; Prombandankul, Awapa; Kanjanahattakij, Napatt; Rungaramsin, Sakda; Wisaratapong, Treechada; Ngarmukos, Tachapong

    2016-03-01

    Brugada syndrome (BrS) is defined as presenting of type-1 Brugada pattern (BrP). BrS can also be induced by fever. This study demonstrated a highest prevalence of fever-induced BrS ever reported. During May 2014, febrile (oral temperature ≥ 38 °C) and nonfebrile patients underwent standard and high leads (V1 and V2 at 2nd intercostal space) electrocardiogram. Risk factor and cardiac symptoms were recorded. Patients with a persistent of type-1 BrP after fever had subsided were excluded. The prevalence of BrS, type-2 BrP and early repolarization pattern (ERP) were demonstrated. A total of 401 patients, 152 febrile, and 249 nonfebrile, were evaluated. BrS was identified in six febrile patients (five males and one female) and two males in nonfebrile patients. The study demonstrated higher prevalence of BrS in febrile group compared to nonfebrile group (4.0% vs 0.8%, respectively, P = 0.037). Among fever-induced BrS patients, three patients (50.0%) experienced cardiac symptoms before and at the time of presentation and two patients (33.3%) had history of first-degree relative sudden death. No ventricular arrhythmia was observed. All of type-1 BrP disappeared after fever had subsided. We found no difference in prevalence of type-2 BrP in febrile and nonfebrile group (2.0% vs 2.8%, respectively, P > 0.05) as well as ERP (3.3% vs 6.4%, respectively, P > 0.05). Our study showed a highest prevalence of fever induced BrS ever reported. A larger study of prevalence, risk stratification, genetic test and management of fever-induced BrS should be done, especially in an endemic area. © 2015, Wiley Periodicals, Inc.

  18. The Global Geodetic Observing System: Space Geodesy Networks for the Future

    Science.gov (United States)

    Pearlman, Michael; Pavlis, Erricos; Ma, Chopo; Altamini, Zuheir; Noll, Carey; Stowers, David

    2011-01-01

    Ground-based networks of co-located space geodetic techniques (VLBI, SLR, GNSS. and DORIS) are the basis for the development and maintenance of the International Terrestrial Reference frame (ITRF), which is our metric of reference for measurements of global change, The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) has established a task to develop a strategy to design, integrate and maintain the fundamental geodetic network and supporting infrastructure in a sustainable way to satisfy the long-term requirements for the reference frame. The GGOS goal is an origin definition at 1 mm or better and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale and orientation components. These goals are based on scientific requirements to address sea level rise with confidence, but other applications are not far behind. Recent studies including one by the US National Research Council has strongly stated the need and the urgency for the fundamental space geodesy network. Simulations are underway to examining accuracies for origin, scale and orientation of the resulting ITRF based on various network designs and system performance to determine the optimal global network to achieve this goal. To date these simulations indicate that 24 - 32 co-located stations are adequate to define the reference frame and a more dense GNSS and DORIS network will be required to distribute the reference frame to users anywhere on Earth. Stations in the new global network will require geologically stable sites with good weather, established infrastructure, and local support and personnel. GGOS wil seek groups that are interested in participation. GGOS intends to issues a Call for Participation of groups that would like to contribute in the network implementation and operation. Some examples of integrated stations currently in operation or under development will be presented. We will examine necessary conditions and challenges in

  19. Using an atmospheric turbulence model for the stochastic model of geodetic VLBI data analysis

    Science.gov (United States)

    Halsig, Sebastian; Artz, Thomas; Iddink, Andreas; Nothnagel, Axel

    2016-06-01

    Space-geodetic techniques at radio wavelength, such as global navigation satellite systems and very long baseline interferometry (VLBI), suffer from refractivity of the Earth's atmosphere. These highly dynamic processes, particularly refractivity variations in the neutral atmosphere, contribute considerably to the error budget of these space-geodetic techniques. Here, microscale fluctuations in refractivity lead to elevation-dependent uncertainties and induce physical correlations between the observations. However, up to now such correlations are not considered routinely in the stochastic model of space-geodetic observations, which leads to very optimistic standard deviations of the derived target parameters, such as Earth orientation parameters and station positions. In this study, the standard stochastic model of VLBI observations, which only includes, almost exclusively, the uncertainties from the VLBI correlation process, is now augmented by a variance-covariance matrix derived from an atmospheric turbulence model. Thus, atmospheric refractivity fluctuations in space and time can be quantified. One of the main objectives is to realize a suitable stochastic model of VLBI observations in an operational way. In order to validate the new approach, the turbulence model is applied to several VLBI observation campaigns consisting of different network geometries leading the path for the next-generation VLBI campaigns. It is shown that the stochastic model of VLBI observations can be improved by using high-frequency atmospheric variations and, thus, refining the stochastic model leads to far more realistic standard deviations of the target parameters. The baseline length repeatabilities as a general measure of accuracy of baseline length determinations improve for the turbulence-based solution. Further, this method is well suited for routine VLBI data analysis with limited computational costs.

  20. Precise Orbital and Geodetic Parameter Estimation using SLR Observations for ILRS AAC

    Science.gov (United States)

    Kim, Young-Rok; Park, Eunseo; Oh, Hyungjik Jay; Park, Sang-Young; Lim, Hyung-Chul; Park, Chandeok

    2013-12-01

    In this study, we present results of precise orbital geodetic parameter estimation using satellite laser ranging (SLR) observations for the International Laser Ranging Service (ILRS) associate analysis center (AAC). Using normal point observations of LAGEOS-1, LAGEOS-2, ETALON-1, and ETALON-2 in SLR consolidated laser ranging data format, the NASA/ GSFC GEODYN II and SOLVE software programs were utilized for precise orbit determination (POD) and finding solutions of a terrestrial reference frame (TRF) and Earth orientation parameters (EOPs). For POD, a weekly-based orbit determination strategy was employed to process SLR observations taken from 20 weeks in 2013. For solutions of TRF and EOPs, loosely constrained scheme was used to integrate POD results of four geodetic SLR satellites. The coordinates of 11 ILRS core sites were determined and daily polar motion and polar motion rates were estimated. The root mean square (RMS) value of post-fit residuals was used for orbit quality assessment, and both the stability of TRF and the precision of EOPs by external comparison were analyzed for verification of our solutions. Results of post-fit residuals show that the RMS of the orbits of LAGEOS-1 and LAGEOS-2 are 1.20 and 1.12 cm, and those of ETALON-1 and ETALON-2 are 1.02 and 1.11 cm, respectively. The stability analysis of TRF shows that the mean value of 3D stability of the coordinates of 11 ILRS core sites is 7.0 mm. An external comparison, with respect to International Earth rotation and Reference systems Service (IERS) 08 C04 results, shows that standard deviations of polar motion XP and YP are 0.754 milliarcseconds (mas) and 0.576 mas, respectively. Our results of precise orbital and geodetic parameter estimation are reasonable and help advance research at ILRS AAC.

  1. Precise Orbital and Geodetic Parameter Estimation using SLR Observations for ILRS AAC

    Directory of Open Access Journals (Sweden)

    Young-Rok Kim

    2013-12-01

    Full Text Available In this study, we present results of precise orbital geodetic parameter estimation using satellite laser ranging (SLR observations for the International Laser Ranging Service (ILRS associate analysis center (AAC. Using normal point observations of LAGEOS-1, LAGEOS-2, ETALON-1, and ETALON-2 in SLR consolidated laser ranging data format, the NASA/ GSFC GEODYN II and SOLVE software programs were utilized for precise orbit determination (POD and finding solutions of a terrestrial reference frame (TRF and Earth orientation parameters (EOPs. For POD, a weekly-based orbit determination strategy was employed to process SLR observations taken from 20 weeks in 2013. For solutions of TRF and EOPs, loosely constrained scheme was used to integrate POD results of four geodetic SLR satellites. The coordinates of 11 ILRS core sites were determined and daily polar motion and polar motion rates were estimated. The root mean square (RMS value of post-fit residuals was used for orbit quality assessment, and both the stability of TRF and the precision of EOPs by external comparison were analyzed for verification of our solutions. Results of post-fit residuals show that the RMS of the orbits of LAGEOS-1 and LAGEOS-2 are 1.20 and 1.12 cm, and those of ETALON-1 and ETALON-2 are 1.02 and 1.11 cm, respectively. The stability analysis of TRF shows that the mean value of 3D stability of the coordinates of 11 ILRS core sites is 7.0 mm. An external comparison, with respect to International Earth rotation and Reference systems Service (IERS 08 C04 results, shows that standard deviations of polar motion Xp and Yp are 0.754 milliarcseconds (mas and 0.576 mas, respectively. Our results of precise orbital and geodetic parameter estimation are reasonable and help advance research at ILRS AAC.

  2. ESPACE - a geodetic Master's program for the education of Satellite Application Engineers

    Science.gov (United States)

    Hedman, K.; Kirschner, S.; Seitz, F.

    2012-04-01

    In the last decades there has been a rapid development of new geodetic and other Earth observation satellites. Applications of these satellites such as car navigation systems, weather predictions, and, digital maps (such as Google Earth or Google Maps) play a more and more important role in our daily life. For geosciences, satellite applications such as remote sensing and precise positioning/navigation have turned out to be extremely useful and are meanwhile indispensable. Today, researchers within geodesy, climatology, oceanography, meteorology as well as within Earth system science are all dependent on up-to-date satellite data. Design, development and handling of these missions require experts with knowledge not only in space engineering, but also in the specific applications. That gives rise to a new kind of engineers - satellite application engineers. The study program for these engineers combines parts of different classical disciplines such as geodesy, aerospace engineering or electronic engineering. The satellite application engineering program Earth Oriented Space Science and Technology (ESPACE) was founded in 2005 at the Technische Universität München, mainly from institutions involved in geodesy and aerospace engineering. It is an international, interdisciplinary Master's program, and is open to students with a BSc in both Science (e.g. Geodesy, Mathematics, Informatics, Geophysics) and Engineering (e.g. Aerospace, Electronical and Mechanical Engineering). The program is completely conducted in English. ESPACE benefits from and utilizes its location in Munich with its unique concentration of expertise related to space science and technology. Teaching staff from 3 universities (Technische Universität München, Ludwig-Maximilian University, University of the Federal Armed Forces), research institutions (such as the German Aerospace Center, DLR and the German Geodetic Research Institute, DGFI) and space industry (such as EADS or Kayser-Threde) are

  3. Data Democracy in Simultaneous Monte Carlo Optimizations of Geodetic and Seismological Data

    Science.gov (United States)

    Sudhaus, H.; Heimann, S.

    2012-04-01

    Estimating the geometry of an earthquake source from seismological and/or geodetic data is a non-linear problem. Often, Monte Carlo optimizations methods are used to find the optimum earthquake model through a clever sampling of the misfit function in the multidimensional model space. The topology of the misfit function, however, very much depends on the data weights we assign. Consequently, also the best fitting model is influenced by the choice of data weights. Data weighting in general is commonly applied these days. Still, there is a large variation between simple arbitrary data weight assignments and weights calculated from estimated data error estimations or trial modeling results. In geodetic source modeling, an accepted and regularly applied procedure is to weight the data, e. g. GPS and InSAR data, according to their quality by using the data error variance-covariance matrix. In this way, we consider correlations of densely spaced data and the data weight factors are independent of the model parametrization. In seismological source studies, the data weighting often appears to be done in a more simple manner. Qualitatively, the azimuthal coverage is taken care of and only sometimes relative weights for different stations are assigned, e. g. based on apparent noise. In a combination of geodetic and seismological data a common rationale for finding the weights would be desirable and moreover we need to find meaningful weighting between the data of different nature, like seismological and GPS data. We present such data weighting in a case study on the 2010 Haiti earthquake to test whether this improves a combined optimization of seismological and geodetic data. For the fault that ruptured during the 2010 Haiti earthquake there are so far at least four different published fault slip models. And, as is often the case, these four are not easily comparable because (1) each model differs from the other to some extent with respect to the model parametrization and

  4. Venlafaxine extended release versus conventional antidepressants in the remission of depressive disorders after previous antidepressant failure: ARGOS study.

    Science.gov (United States)

    Baldomero, E Baca; Ubago, J Giner; Cercós, C Leal; Ruiloba, J Vallejo; Calvo, C García; López, R Prieto

    2005-01-01

    Serotonin-norepinephrine reuptake inhibitors (SNRIs) may be used as an alternative treatment for depressed patients who do not tolerate or respond adequately to treatment with a conventional antidepressant. This randomized, open-label, multicenter study compared the effectiveness of the SNRI venlafaxine extended release (VXR) with that of conventional antidepressants (CA) in patients who were referred to an outpatient psychiatric specialty care setting for treatment after failure to tolerate or respond to at least 4 weeks of treatment with a CA in a primary care setting. Patients with a Hamilton Depression Rating Scale (HAM-D17) score > or =17 were randomly assigned to treatment with an alternative CA or VXR. Remission was defined as a score < or =7 on the HAM-D17. Efficacy analyses were carried out on 3,097 patients from the intent-to-treat (ITT) population (1,632 VXR; 1,465 CA). The antidepressants prescribed most frequently in the CA group were paroxetine (21.3%), citalopram (20.1%), sertraline (19.1%), fluoxetine (17.0%), and mirtazapine (7.9%). After 24 weeks of treatment, the VXR group demonstrated a significantly higher remission rate than did the CA group (59.3% VXR; 51.5% CA; P<.0001; odds ratio: 1.37; 95% CI: 1.19-1.58; P<.01). Despite the limitations of the open design, the results of this study suggest that venlafaxine extended release may be more effective than the conventional antidepressants used in this study when treating depressed patients who do not tolerate or respond adequately to treatment with a conventional antidepressant.

  5. CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.

    Science.gov (United States)

    Goujon, Catherine; Gougeon, Marie-Lise; Tondeur, Laura; Poirier, Béatrice; Seffer, Valérie; Desprès, Philippe; Consigny, Paul-Henri; Vray, Muriel

    2017-10-27

    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area. A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Cases were defined as infants immunized with the yellow fever vaccine and with the measles vaccine, either alone or in combination with mumps and rubella vaccine, with a period of 1-27days between each immunization. For each case, two controls were matched based on sex and age: a first control group (control 1) was defined as infants having received the measles vaccine and the yellow fever vaccine simultaneously; a second control group (control 2) was defined as infants who had a period of more than 27days between receiving the measles vaccine and yellow fever vaccine. The primary endpoint of the study was the percentage of infants with protective immunity against yellow fever, measured by the titer of neutralizing antibodies in a venous blood sample. One hundred and thirty-one infants were included in the study (62 cases, 50 infants in control 1 and 19 infants in control 2). Of these, 127 (96%) were shown to have a protective titer of yellow fever antibodies. All 4 infants without a protective titer of yellow fever antibodies were part of control group 1. The measles vaccine, alone or combined with mumps and rubella vaccines, appears to have no influence on humoral immune response to the yellow fever vaccine when administered between 1 and 27

  6. Self-shielding effects in burnup of Gd used as burnable absorber. Previous studies on its experimental verification

    International Nuclear Information System (INIS)

    Abbate, Maximo J.; Sbaffoni, Maria M.

    2003-01-01

    Continuing with the domestic 'Burnable Absorbers Research Plan' studies were done to estimate self-shielding effects during Gd 2 O 3 burnup as burnable absorber included in fuel pins of a CAREM geometry. In this way, its burnup was calculated without and with self-shielding. For the second case, were obtained values depending on internal pin radius and the effective one for the homogenized pin. For Gd 157, the burnup corresponding to the first case resulted 52.6 % and of 1.23 % for the effective one. That shows the magnitude of the effects under study. Considering that is necessary to perform one experimental verification, also are presented calculational results for the case to irradiate a pellet containing UO 2 (natural) and 8 wt % of Gd 2 O 3 , as a function of cooling time, that include: measurable isotopes concentrations, expected activities, and photon spectra for conditions able to be compared with bidimensional calculations with self-shielding. The irradiation time was supposed 30 dpp using RA-3 reactor at 10 MW. (author)

  7. A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

    Directory of Open Access Journals (Sweden)

    Bin Cui

    Full Text Available BACKGROUND: Genome-wide association study (GWAS has identified more than 30 loci associated with type 2 diabetes (T2D in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited. METHODS AND PRINCIPAL FINDINGS: A two-stage GWAS was performed in Han Chinese from Mainland China. The discovery stage included 793 T2D cases and 806 healthy controls genotyped using Illumina Human 660- and 610-Quad BeadChips; and the replication stage included two independent case-control populations (a total of 4445 T2D cases and 4458 controls genotyped using TaqMan assay. We validated the associations of KCNQ1 (rs163182, p = 2.085×10(-17, OR 1.28 and C2CD4A/B (rs1370176, p = 3.677×10(-4, OR 1.124; rs1436953, p = 7.753×10(-6, OR 1.141; rs7172432, p = 4.001×10(-5, OR 1.134 in Han Chinese. CONCLUSIONS AND SIGNIFICANCE: Our study represents the first GWAS of T2D with both discovery and replication sample sets recruited from Han Chinese men and women residing in Mainland China. We confirmed the associations of KCNQ1 and C2CD4A/B with T2D, with the latter for the first time being examined in Han Chinese. Arguably, eight more independent loci were replicated in our GWAS.

  8. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media.

    Science.gov (United States)

    Morel, Mike E; McBride, Simon E; Gomez, Maria P

    2017-12-01

    The suitability and stability of cervical cells in Novaprep media (NHQ) for certain HPV assays is unknown. We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV) for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months' stability at 18-25°C, 2-8°C, -20°C and -80°C; and at least 3 months' stability at 40°C. Similar results were obtained for pre-treated NHQ except only 3.5 months' stability at 18-25°C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  9. Knowledge of stroke risk factors among primary care patients with previous stroke or TIA: a questionnaire study

    Directory of Open Access Journals (Sweden)

    Strender Lars-Erik

    2010-06-01

    Full Text Available Abstract Background Survivers of stroke or transient ischaemic attacks (TIA are at risk of new vascular events. Our objective was to study primary health care patients with stroke/TIA regarding their knowledge about risk factors for having a new event of stroke/TIA, possible associations between patient characteristics and patients' knowledge about risk factors, and patients' knowledge about their preventive treatment for stroke/TIA. Methods A questionnaire was distributed to 240 patients with stroke/TIA diagnoses, and 182 patients (76% responded. We asked 13 questions about diseases/conditions and lifestyle factors known to be risk factors and four questions regarding other diseases/conditions ("distractors". The patients were also asked whether they considered each disease/condition to be one of their own. Additional questions concerned the patients' social and functional status and their drug use. The t-test was used for continuous variables, chi-square test for categorical variables, and a regression model with variables influencing patient knowledge was created. Results Hypertension, hyperlipidemia and smoking were identified as risk factors by nearly 90% of patients, and atrial fibrillation and diabetes by less than 50%. Few patients considered the distractors as stroke/TIA risk factors (3-6%. Patients with a family history of cardiovascular disease, and patients diagnosed with carotid stenosis, atrial fibrillation or diabetes, knew these were stroke/TIA risk factors to a greater extent than patients without these conditions. Atrial fibrillation or a family history of cardiovascular disease was associated with better knowledge about risk factors, and higher age, cerebral haemorrhage and living alone with poorer knowledge. Only 56% of those taking anticoagulant drugs considered this as intended for prevention, while 48% of those taking platelet aggregation inhibitors thought this was for prevention. Conclusions Knowledge about hypertension

  10. A magma chamber model beneath Unzen Volcano inferred from geodetic and seismic data using FEM

    Science.gov (United States)

    Kohno, Y.; Matsumoto, S.; Matsushima, T.; Uehira, K.; Umakoshi, K.; Shimizu, H.

    2008-12-01

    A supplying system of the magma beneath Unzen volcano has been proposed using both geodetic and seismic data simultaneously. Spatial variation of geodetic data is affected by change of magma body in both of shape and pressure. In most cases, relative stress field is able to be inferred from focal mechanisms of earthquakes. This changing also disturbs stress field in the region around the magma chamber. A model about shape and internal pressure of magma chamber is constrained by mean of both grounds deformation and focal mechanism. Unzen Volcano is the massive volcanic complex, located in the middle part of Kyushu Island, Japan, erupted accompanying by pyroclastic flows and formed a huge lava dome at the summit during 1990-1995. Based on geodetic data during period 1991-2004, a magma chamber model composed of four pressure sources was constructed by grid search method (Kohno et al., 2008). For the data with greater crustal deformation observed in 1992-93 and 1993-94, we applied finite element method (FEM) to model the magma chamber. Especially, shape of a pressure source at a depth of 7 km (C-source) was also estimated in this searching process. C-source during 1992-93 has an oblate spheroid with south-southwest dip oriented made good correlation with observation data. Regards only from ground deformation data, the length of the major axis is smaller than 3km. The shape sustains to an idea that magma ascends easily toward the shallower chamber. The best solution of C-source in 1993-94 was obtained as a prolate spheroid source with north dip oriented. This latter source is smaller size and dipping to opposite side with the previous one. Although they are separated at distance of 1 km, this is not far to call different magma chamber each other. Different shape indicated that inhomogeneous structure of magma chamber. From this arrangement of the sources, we considered a model that the magma chamber at a depth of about 7 km could be composed of small magma chambers like

  11. Large earthquake rates from geologic, geodetic, and seismological perspectives

    Science.gov (United States)

    Jackson, D. D.

    2017-12-01

    Earthquake rate and recurrence information comes primarily from geology, geodesy, and seismology. Geology gives the longest temporal perspective, but it reveals only surface deformation, relatable to earthquakes only with many assumptions. Geodesy is also limited to surface observations, but it detects evidence of the processes leading to earthquakes, again subject to important assumptions. Seismology reveals actual earthquakes, but its history is too short to capture important properties of very large ones. Unfortunately, the ranges of these observation types barely overlap, so that integrating them into a consistent picture adequate to infer future prospects requires a great deal of trust. Perhaps the most important boundary is the temporal one at the beginning of the instrumental seismic era, about a century ago. We have virtually no seismological or geodetic information on large earthquakes before then, and little geological information after. Virtually all-modern forecasts of large earthquakes assume some form of equivalence between tectonic- and seismic moment rates as functions of location, time, and magnitude threshold. That assumption links geology, geodesy, and seismology, but it invokes a host of other assumptions and incurs very significant uncertainties. Questions include temporal behavior of seismic and tectonic moment rates; shape of the earthquake magnitude distribution; upper magnitude limit; scaling between rupture length, width, and displacement; depth dependence of stress coupling; value of crustal rigidity; and relation between faults at depth and their surface fault traces, to name just a few. In this report I'll estimate the quantitative implications for estimating large earthquake rate. Global studies like the GEAR1 project suggest that surface deformation from geology and geodesy best show the geography of very large, rare earthquakes in the long term, while seismological observations of small earthquakes best forecasts moderate earthquakes

  12. IGSM Croatia 2010, International Geodetic Students Meeting, University of Zagreb, Faculty of Geodesy, Zagreb, 2010

    OpenAIRE

    Sandra Keran

    2010-01-01

    IGSM (International Geodetic Students Meeting) is an international meeting of students from geodetic and similar faculties which has been held for 23 years. It all began with the Technical University students’ meeting in the Dutch city Delft which was held in order to compare programs of European geodetic faculties. About 150 students from 15 faculties and 7 countries replied to their invitation. Nowadays, the number of member countries exceeds 30 and countries outside Europe are also include...

  13. The current state of the creation and modernization of national geodetic and cartographic resources in Poland

    Directory of Open Access Journals (Sweden)

    Doskocz Adam

    2016-01-01

    Full Text Available All official data are currently integrated and harmonized in a spatial reference system. This paper outlines a national geodetic and cartographic resources in Poland. The national geodetic and cartographic resources are an important part of the spatial information infrastructure in the European Community. They also provide reference data for other resources of Spatial Data Infrastructure (SDI, including: main and detailed geodetic control networks, base maps, land and buildings registries, geodetic registries of utilities and topographic maps. This paper presents methods of producing digital map data and technical standards for field surveys, and in addition paper also presents some aspects of building Global and Regional SDI.

  14. Geodetic constraints on frictional properties and earthquake hazard in the Imperial Valley, Southern California

    Science.gov (United States)

    Lindsey, Eric O.; Fialko, Yuri

    2016-02-01

    We analyze a suite of geodetic observations across the Imperial Fault in southern California that span all parts of the earthquake cycle. Coseismic and postseismic surface slips due to the 1979 M 6.6 Imperial Valley earthquake were recorded with trilateration and alignment surveys by Harsh (1982) and Crook et al. (1982), and interseismic deformation is measured using a combination of multiple interferometric synthetic aperture radar (InSAR)-viewing geometries and continuous and survey-mode GPS. In particular, we combine more than 100 survey-mode GPS velocities with InSAR data from Envisat descending tracks 84 and 356 and ascending tracks 77 and 306 (149 total acquisitions), processed using a persistent scatterers method. The result is a dense map of interseismic velocities across the Imperial Fault and surrounding areas that allows us to evaluate the rate of interseismic loading and along-strike variations in surface creep. We compare available geodetic data to models of the earthquake cycle with rate- and state-dependent friction and find that a complete record of the earthquake cycle is required to constrain key fault properties including the rate-dependence parameter (a - b) as a function of depth, the extent of shallow creep, and the recurrence interval of large events. We find that the data are inconsistent with a high (>30 mm/yr) slip rate on the Imperial Fault and investigate the possibility that an extension of the San Jacinto-Superstition Hills Fault system through the town of El Centro may accommodate a significant portion of the slip previously attributed to the Imperial Fault. Models including this additional fault are in better agreement with the available observations, suggesting that the long-term slip rate of the Imperial Fault is lower than previously suggested and that there may be a significant unmapped hazard in the western Imperial Valley.

  15. An Autonomous, Low Cost Platform for Seafloor Geodetic Observations

    Science.gov (United States)

    Ericksen, T.; Foster, J. H.; Bingham, B. S.

    2013-12-01

    The high cost of acquiring geodetic data from the sea floor has limited the observations available to help us understand and model the behavior of seafloor geodetic processes. To address this problem, the Pacific GPS Facility at the University of Hawaii is developing a cost effective approach for accurately measuring short-term vertical motions of the seafloor and maintaining a continuous long-term record of seafloor pressure without the requirement for costly ship time. There is a recognized need to vastly increase our underwater geodetic observing capacity. Most of the largest recorded earthquakes and most devastating tsunamis are generated at subduction zones underwater. Similarly, many volcanoes are partly (e.g. Santorini) or completely (e.g. Loihi) submerged, and are not well observed and understood. Furthermore, landslide features ring many ocean basins, and huge debris deposits surround many volcanic oceanic islands. Our approach will lower the cost of collecting sea-floor geodetic data, reducing the barriers preventing us from acquiring the information we need to observe and understand these types of structures and provide a direct societal benefit in improving hazard assessment. The capability is being developed by equipping one of the University of Hawaii Wave Gliders with an integrated acoustic telemetry package, a dual frequency geodetic-grade Global Positioning System (GPS) receiver, processing unit, and cellular communications. The Wave Glider will interrogate high accuracy pressure sensors on the sea floor to maintain a near-continuous stream of pressure and temperature data, but seafloor pressure data includes contribution from a variety of sources and on its own may not provide the accuracy required for geodetic investigations. Independent measurements of sea surface pressure and sea surface height can be used to remove these contributions from the observed sea floor pressure timeseries. We will integrate our seafloor pressure measurements with air

  16. Space geodetic techniques for global modeling of ionospheric peak parameters

    Science.gov (United States)

    Alizadeh, M. Mahdi; Schuh, Harald; Schmidt, Michael

    The rapid development of new technological systems for navigation, telecommunication, and space missions which transmit signals through the Earth’s upper atmosphere - the ionosphere - makes the necessity of precise, reliable and near real-time models of the ionospheric parameters more crucial. In the last decades space geodetic techniques have turned into a capable tool for measuring ionospheric parameters in terms of Total Electron Content (TEC) or the electron density. Among these systems, the current space geodetic techniques, such as Global Navigation Satellite Systems (GNSS), Low Earth Orbiting (LEO) satellites, satellite altimetry missions, and others have found several applications in a broad range of commercial and scientific fields. This paper aims at the development of a three-dimensional integrated model of the ionosphere, by using various space geodetic techniques and applying a combination procedure for computation of the global model of electron density. In order to model ionosphere in 3D, electron density is represented as a function of maximum electron density (NmF2), and its corresponding height (hmF2). NmF2 and hmF2 are then modeled in longitude, latitude, and height using two sets of spherical harmonic expansions with degree and order 15. To perform the estimation, GNSS input data are simulated in such a way that the true position of the satellites are detected and used, but the STEC values are obtained through a simulation procedure, using the IGS VTEC maps. After simulating the input data, the a priori values required for the estimation procedure are calculated using the IRI-2012 model and also by applying the ray-tracing technique. The estimated results are compared with F2-peak parameters derived from the IRI model to assess the least-square estimation procedure and moreover, to validate the developed maps, the results are compared with the raw F2-peak parameters derived from the Formosat-3/Cosmic data.

  17. Geodetic Space Weather Monitoring by means of Ionosphere Modelling

    Science.gov (United States)

    Schmidt, Michael

    2017-04-01

    The term space weather indicates physical processes and phenomena in space caused by radiation of energy mainly from the Sun. Manifestations of space weather are (1) variations of the Earth's magnetic field, (2) the polar lights in the northern and southern hemisphere, (3) variations within the ionosphere as part of the upper atmosphere characterized by the existence of free electrons and ions, (4) the solar wind, i.e. the permanent emission of electrons and photons, (5) the interplanetary magnetic field, and (6) electric currents, e.g. the van Allen radiation belt. It can be stated that ionosphere disturbances are often caused by so-called solar storms. A solar storm comprises solar events such as solar flares and coronal mass ejections (CMEs) which have different effects on the Earth. Solar flares may cause disturbances in positioning, navigation and communication. CMEs can effect severe disturbances and in extreme cases damages or even destructions of modern infrastructure. Examples are interruptions to satellite services including the global navigation satellite systems (GNSS), communication systems, Earth observation and imaging systems or a potential failure of power networks. Currently the measurements of solar satellite missions such as STEREO and SOHO are used to forecast solar events. Besides these measurements the Earth's ionosphere plays another key role in monitoring the space weather, because it responses to solar storms with an increase of the electron density. Space-geodetic observation techniques, such as terrestrial GNSS, satellite altimetry, space-borne GPS (radio occultation), DORIS and VLBI provide valuable global information about the state of the ionosphere. Additionally geodesy has a long history and large experience in developing and using sophisticated analysis and combination techniques as well as empirical and physical modelling approaches. Consequently, geodesy is predestinated for strongly supporting space weather monitoring via

  18. Determining Coastal Mean Dynamic Topography by Geodetic Methods

    Science.gov (United States)

    Huang, Jianliang

    2017-11-01

    In geodesy, coastal mean dynamic topography (MDT) was traditionally determined by spirit leveling technique. Advances in navigation satellite positioning (e.g., GPS) and geoid determination enable space-based leveling with an accuracy of about 3 cm at tide gauges. Recent CryoSat-2, a satellite altimetry mission with synthetic aperture radar (SAR) and SAR interferometric measurements, extends the space-based leveling to the coastal ocean with the same accuracy. However, barriers remain in applying the two space-based geodetic methods for MDT determination over the coastal ocean because current geoid modeling focuses primarily on land as a substitute to spirit leveling to realize the vertical datum.

  19. Optimal Design of Geodetic Network Using Genetic Algorithms

    Science.gov (United States)

    Vajedian, Sanaz; Bagheri, Hosein

    2010-05-01

    A geodetic network is a network which is measured exactly by techniques of terrestrial surveying based on measurement of angles and distances and can control stability of dams, towers and their around lands and can monitor deformation of surfaces. The main goals of an optimal geodetic network design process include finding proper location of control station (First order Design) as well as proper weight of observations (second order observation) in a way that satisfy all the criteria considered for quality of the network with itself is evaluated by the network's accuracy, reliability (internal and external), sensitivity and cost. The first-order design problem, can be dealt with as a numeric optimization problem. In this designing finding unknown coordinates of network stations is an important issue. For finding these unknown values, network geodetic observations that are angle and distance measurements must be entered in an adjustment method. In this regard, using inverse problem algorithms is needed. Inverse problem algorithms are methods to find optimal solutions for given problems and include classical and evolutionary computations. The classical approaches are analytical methods and are useful in finding the optimum solution of a continuous and differentiable function. Least squares (LS) method is one of the classical techniques that derive estimates for stochastic variables and their distribution parameters from observed samples. The evolutionary algorithms are adaptive procedures of optimization and search that find solutions to problems inspired by the mechanisms of natural evolution. These methods generate new points in the search space by applying operators to current points and statistically moving toward more optimal places in the search space. Genetic algorithm (GA) is an evolutionary algorithm considered in this paper. This algorithm starts with definition of initial population, and then the operators of selection, replication and variation are applied

  20. Slip deficit on the san andreas fault at parkfield, california, as revealed by inversion of geodetic data.

    Science.gov (United States)

    Segall, P; Harris, R

    1986-09-26

    A network of geodetic lines spanning the San Andreas fault near the rupture zone of the 1966 Parkfield, California, earthquake (magnitude M = 6) has been repeatedly surveyed since 1959. In the study reported here the average rates of line-length change since 1966 were inverted to determine the distribution of interseismic slip rate on the fault. These results indicate that the Parkfield rupture surface has not slipped significantly since 1966. Comparison of the geodetically determined seismic moment of the 1966 earthquake with the interseismic slip-deficit rate suggests that the strain released by the latest shock will most likely be restored between 1984 and 1989, although this may not occur until 1995. These results lend independent support to the earlier forecast of an M = 6 earthquake near Parkfield within 5 years of 1988.

  1. NEAR REAL-TIME DETERMINATION OF EARTHQUAKE SOURCE PARAMETERS FOR TSUNAMI EARLY WARNING FROM GEODETIC OBSERVATIONS

    Directory of Open Access Journals (Sweden)

    S. Manneela

    2016-06-01

    Full Text Available Exemplifying the tsunami source immediately after an earthquake is the most critical component of tsunami early warning, as not every earthquake generates a tsunami. After a major under sea earthquake, it is very important to determine whether or not it has actually triggered the deadly wave. The near real-time observations from near field networks such as strong motion and Global Positioning System (GPS allows rapid determination of fault geometry. Here we present a complete processing chain of Indian Tsunami Early Warning System (ITEWS, starting from acquisition of geodetic raw data, processing, inversion and simulating the situation as it would be at warning center during any major earthquake. We determine the earthquake moment magnitude and generate the centroid moment tensor solution using a novel approach which are the key elements for tsunami early warning. Though the well established seismic monitoring network, numerical modeling and dissemination system are currently capable to provide tsunami warnings to most of the countries in and around the Indian Ocean, the study highlights the critical role of geodetic observations in determination of tsunami source for high-quality forecasting.

  2. Simulations of VLBI observations of a geodetic satellite providing co-location in space

    Science.gov (United States)

    Anderson, James M.; Beyerle, Georg; Glaser, Susanne; Liu, Li; Männel, Benjamin; Nilsson, Tobias; Heinkelmann, Robert; Schuh, Harald

    2018-02-01

    We performed Monte Carlo simulations of very-long-baseline interferometry (VLBI) observations of Earth-orbiting satellites incorporating co-located space-geodetic instruments in order to study how well the VLBI frame and the spacecraft frame can be tied using such measurements. We simulated observations of spacecraft by VLBI observations, time-of-flight (TOF) measurements using a time-encoded signal in the spacecraft transmission, similar in concept to precise point positioning, and differential VLBI (D-VLBI) observations using angularly nearby quasar calibrators to compare their relative performance. We used the proposed European Geodetic Reference Antenna in Space (E-GRASP) mission as an initial test case for our software. We found that the standard VLBI technique is limited, in part, by the present lack of knowledge of the absolute offset of VLBI time to Coordinated Universal Time at the level of microseconds. TOF measurements are better able to overcome this problem and provide frame ties with uncertainties in translation and scale nearly a factor of three smaller than those yielded from VLBI measurements. If the absolute time offset issue can be resolved by external means, the VLBI results can be significantly improved and can come close to providing 1 mm accuracy in the frame tie parameters. D-VLBI observations with optimum performance assumptions provide roughly a factor of two higher uncertainties for the E-GRASP orbit. We additionally simulated how station and spacecraft position offsets affect the frame tie performance.

  3. Geodetic reanalysis of annual glaciological mass balances (2001-2011) of Hintereisferner, Austria

    Science.gov (United States)

    Klug, Christoph; Bollmann, Erik; Galos, Stephan Peter; Nicholson, Lindsey; Prinz, Rainer; Rieg, Lorenzo; Sailer, Rudolf; Stötter, Johann; Kaser, Georg

    2018-03-01

    This study presents a reanalysis of the glaciologically obtained annual glacier mass balances at Hintereisferner, Ötztal Alps, Austria, for the period 2001-2011. The reanalysis is accomplished through a comparison with geodetically derived mass changes, using annual high-resolution airborne laser scanning (ALS). The grid-based adjustments for the method-inherent differences are discussed along with associated uncertainties and discrepancies of the two methods of mass balance measurements. A statistical comparison of the two datasets shows no significant difference for seven annual, as well as the cumulative, mass changes over the 10-year record. Yet, the statistical view hides significant differences in the mass balance years 2002/03 (glaciological minus geodetic records = +0.92 m w.e.), 2005/06 (+0.60 m w.e.), and 2006/07 (-0.45 m w.e.). We conclude that exceptional meteorological conditions can render the usual glaciological observational network inadequate. Furthermore, we consider that ALS data reliably reproduce the annual mass balance and can be seen as validation or calibration tools for the glaciological method.

  4. The integration of astro-geodetic data observed with ACSYS to the local geoid models Istanbul-Turkey

    Science.gov (United States)

    Halicioglu, Kerem; Ozludemir, M. Tevfik; Deniz, Rasim; Ozener, Haluk; Albayrak, Muge; Ulug, Rasit; Basoglu, Burak

    2017-04-01

    Astro-geodetic deflections of the vertical components provide accurate and valuable information of Earth's gravity filed. Conventional methods require considerable effort and time whereas new methods, namely digital zenith camera systems (DZCS), have been designed to eliminate drawbacks of the conventional methods, such as observer dependent errors, long observation times, and to improve the observation accuracy. The observation principle is based on capturing star images near zenithal direction to determine astronomical coordinates of the station point with the integration of CCD, telescope, tiltmeters, and GNSS devices. In Turkey a new DZCS have been designed and tested on control network located in Istanbul, of which the geoid height differences were known with the accuracy of ±3.5 cm. Astro-geodetic Camera System (ACSYS) was used to determine the deflections of the vertical components with an accuracy of ±0.1 - 0.3 arc seconds, and results were compared with geoid height differences using astronomical levelling procedure. The results have also been compared with the ones calculated from global geopotential models. In this study the recent results of the first digital zenith camera system of Turkey are presented and the future studies are introduced such as the current developments of the system including hardware and software upgrades as well as the new observation strategy of the ACSYS. We also discuss the contribution and integration of the astro-geodetic deflections of the vertical components to the geoid determination studies in the light of information of current ongoing projects being operated in Turkey.

  5. Rapid Assessment of Earthquakes with Radar and Optical Geodetic Imaging and Finite Fault Models (Invited)

    Science.gov (United States)

    Fielding, E. J.; Sladen, A.; Simons, M.; Rosen, P. A.; Yun, S.; Li, Z.; Avouac, J.; Leprince, S.

    2010-12-01

    Earthquake responders need to know where the earthquake has caused damage and what is the likely intensity of damage. The earliest information comes from global and regional seismic networks, which provide the magnitude and locations of the main earthquake hypocenter and moment tensor centroid and also the locations of aftershocks. Location accuracy depends on the availability of seismic data close to the earthquake source. Finite fault models of the earthquake slip can be derived from analysis of seismic waveforms alone, but the results can have large errors in the location of the fault ruptures and spatial distribution of slip, which are critical for estimating the distribution of shaking and damage. Geodetic measurements of ground displacements with GPS, LiDAR, or radar and optical imagery provide key spatial constraints on the location of the fault ruptures and distribution of slip. Here we describe the analysis of interferometric synthetic aperture radar (InSAR) and sub-pixel correlation (or pixel offset tracking) of radar and optical imagery to measure ground coseismic displacements for recent large earthquakes, and lessons learned for rapid assessment of future events. These geodetic imaging techniques have been applied to the 2010 Leogane, Haiti; 2010 Maule, Chile; 2010 Baja California, Mexico; 2008 Wenchuan, China; 2007 Tocopilla, Chile; 2007 Pisco, Peru; 2005 Kashmir; and 2003 Bam, Iran earthquakes, using data from ESA Envisat ASAR, JAXA ALOS PALSAR, NASA Terra ASTER and CNES SPOT5 satellite instruments and the NASA/JPL UAVSAR airborne system. For these events, the geodetic data provided unique information on the location of the fault or faults that ruptured and the distribution of slip that was not available from the seismic data and allowed the creation of accurate finite fault source models. In many of these cases, the fault ruptures were on previously unknown faults or faults not believed to be at high risk of earthquakes, so the area and degree of

  6. Current status of the EPOS WG4 - GNSS and Other Geodetic Data

    Science.gov (United States)

    Fernandes, Rui; Bastos, Luisa; Bruyninx, Carine; D'Agostino, Nicola; Dousa, Jan; Ganas, Athanassios; Lidberg, Martin; Nocquet, Jean-Mathieu

    2014-05-01

    WG4 - "EPOS Geodetic Data and Other Geodetic Data" is the Working Group of the EPOS project in charge of defining and preparing the integration of the existing Pan-European Geodetic Infrastructures that will support European Geosciences, which is the ultimate goal of the EPOS project. The WG4 is formed by representatives of the participating EPOS countries (23) but it is also open to the entire geodetic community. In fact, WG4 also already includes members from countries that formally are not integrating EPOS in this first step. The geodetic component of EPOS (WG4) is dealing essentially with Research Infrastructures focused on continuous operating GNSS (cGNSS) in the current phase. The option of concentrating the efforts on the presently most generalized geodetic tool supporting research on Solid Earth was decided in order to optimize the existing resources. Nevertheless, WG4 will continue to pursue the development of tools and methodologies that permit the access of the EPOS community to other geodetic information (e.g., gravimetry). Furthermore, although the focus is on Solid Earth applications, other research and technical applications (e.g., reference frames, meteorology, space weather) can also benefit from the efforts of WG4 EPOS towards the optimization of the geodetic resources in Europe. We will present and discuss the plans for the implementation of the thematic and core services (TCS) for geodetic data within EPOS and the related business plan. We will focus on strategies towards the implementation of the best solutions that will permit to the end-users, and in particular geo-scientists, to access the geodetic data, derived solutions, and associated metadata using transparent and uniform processes. Five pillars have been defined proposed for the TCS: Dissemination, Preservation, Monitoring, and Analysis of geodetic data plus the Support and Governance Infrastructure. Current proposals and remaining open questions will be discussed.

  7. Exploring deformation scenarios in Timanfaya volcanic area (Lanzarote, Canary Islands) from GNSS and ground based geodetic observations

    Science.gov (United States)

    Riccardi, U.; Arnoso, J.; Benavent, M.; Vélez, E.; Tammaro, U.; Montesinos, F. G.

    2018-05-01

    We report on a detailed geodetic continuous monitoring in Timanfaya volcanic area (TVA), where the most intense geothermal anomalies of Lanzarote Island are located. We analyze about three years of GNSS data collected on a small network of five permanent stations, one of which at TVA, deployed on the island, and nearly 20 years of tiltmeter and strainmeter records acquired at Los Camelleros site settled in the facilities of the Geodynamics Laboratory of Lanzarote within TVA. This study is intended to contribute to understanding the active tectonics on Lanzarote Island and its origin, mainly in TVA. After characterizing and filtering out the seasonal periodicities related to "non-tectonic" sources from the geodetic records, a tentative ground deformation field is reconstructed through the analysis of both tilt, strain records and the time evolution of the baselines ranging the GNSS stations. The joint interpretation of the collected geodetic data show that the area of the strongest geothermal anomaly in TVA is currently undergoing a SE trending relative displacement at a rate of about 3 mm/year. This area even experiences a significant subsidence with a maximum rate of about 6 mm/year. Moreover, we examine the possible relation between the observed deformations and atmospheric effects by modelling the response functions of temperature and rain recorded in the laboratory. Finally, from the retrieval of the deformation patterns and the joint analysis of geodetic and environmental observations, we propose a qualitative model of the interplaying role between the hydrological systems and the geothermal anomalies. Namely, we explain the detected time correlation between rainfall and ground deformation because of the enhancement of the thermal transfer from the underground heat source driven by the infiltration of meteoric water.

  8. Geodetic refraction effects of electromagnetic wave propagation through the atmosphere

    CERN Document Server

    1984-01-01

    With very few exceptions, geodetic measurements use electro­ magnetic radiation in order to measure directions, distances, time delays, and Doppler frequency shifts, to name the main ter­ restrial and space observables. Depending on the wavelength of the radiation and the purpose of the measurements, the follow­ ing parameters of the electromagnetic wave are measured: ampli­ tude, phase, angle-of-arrival, polarisation and frequency. Ac­ curate corrections have to be applied to the measurements in order to take into account the effects of the intervening medium between transmitter and receiver. The known solutions use at­ mospheric models, special observation programs, remote sensing techniques and instrumental methods. It has been shown that the effects of the earth's atmospheric envelope present a fundamental limitation to the accuracy and precision of geodetic measurements. This applies equally to ter­ restrial and space applications. Instrumental accuracies are al­ ready below the atmospherically i...

  9. Accuracy of missing lines measured by geodetic total stations

    Directory of Open Access Journals (Sweden)

    Kaifer Jozef

    2001-03-01

    Full Text Available For using line elements (horizontal and slope distances, heights differences of a missing (unaccessible line structure their accuracy are needed. Accuracy analysis of missing hori zontal distances.In some standing geodetic general practice most effective instruments for land measurement from selects going measuring instruments they are geodetic total stations. These apparatures thanks its universal accomplishment and special function make possible measure wide spectrum quantity and following they at its computer trough meet rountines outfit calculate further parameters. GTS fit not only on different genera three – dimensional networks on much good level. Make possible straight measure oblique length D, zenit angle Z, horizontal angle ù and indirectly measure: horizontal length d, trigonometrical hights ∆h, length and level elements for failure parties (missing line and coordinate distinction, respectively position data identification dot.From this auditorium service GTS is indeed actual investigate precision they indirectly measurement quantity. Precision straight measurement quantity (D,Z,ù is for these instruments whenever known (statement manufacturer in shape primer standard divergence alternatively empirical standard divergence discovery employer respectively well objective too in various conditions. Indirectly measurement parametres they are indeed from mathematical auditorium action straight measurement quantity, and so too their precision, which ours interest, myself produce following activity style and effect (transferred their varians.Introduction treatise toward question accurancy of measurement GTS myself orientate just on research precision indirectly measurement (according quantity.

  10. Geodetic contributions to IWRM-projects in middle Java, Indonesia

    Science.gov (United States)

    Schmitt, Günter

    2010-12-01

    The district of Gunung Kidul in middle Java is one of the poorest regions in Indonesia. The essential reason is the acute water scarcity in this karst region during the months of the dry season. As a consequence of the poor living conditions many people have migrated away and therefore the development of the region is stagnating. During the last few years two projects have been initiated under the theme “Integrated Water Resources Management” in order to improve the water supply situation, both funded by the German Federal Ministry of Education and Research, and realized essentially by institutes of the University of Karlsruhe. Geodetic sub-projects are integrated into both projects. Special surveying activities had been, and have still to be, carried out to realise the geometrical basis for several other sub-projects. The particular contributions are 3D cave measurements for visualisation and planning, staking out of drilling points and construction axes, the definition of a common reference system, the surveying of the water distribution network and its technical facilities, the setting up and the management of a geographical information system (GIS), as well as special measurements such as dam monitoring or controlling of a vertical drilling machine. The paper reviews these projects and describes the geodetic activities.

  11. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.

    Science.gov (United States)

    Persky, Victoria; Piorkowski, Julie; Turyk, Mary; Freels, Sally; Chatterton, Robert; Dimos, John; Bradlow, H Leon; Chary, Lin Kaatz; Burse, Virlyn; Unterman, Terry; Sepkovic, Daniel W; McCann, Kenneth

    2012-08-29

    Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive associations of polychlorinated biphenyls (PCBs) and inverse associations of selected steroid hormones with diabetes in postmenopausal women previously employed in a capacitor manufacturing plant. This paper examines associations of PCBs with diabetes and endogenous hormones in 63 men previously employed at the same plant who in 1996 underwent surveys of their exposure and medical history and collection of bloods and urine for measurements of PCBs, lipids, liver function, hematologic markers and endogenous hormones. PCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake. History of diabetes was significantly related to total PCBs and all PCB functional groupings, but not to quarters worked and job score, after control for potential confounders. None of the exposures were related to insulin resistance (HOMA-IR) in non-diabetic men. Associations of PCBs with specific endogenous hormones differ in some respects from previous findings in postmenopausal women employed at the capacitor plant. Results from this study, however, do confirm previous reports relating PCB exposure to diabetes and suggest that these associations are not mediated by measured endogenous hormones.

  12. Study of some physical aspects previous to design of an exponential experiment; Estudio de algunos aspectos fisicos previos al diseno de una experiencia exponencial

    Energy Technology Data Exchange (ETDEWEB)

    Caro, R.; Francisco, J. L. de

    1961-07-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs.

  13. Quantifying the influence of previously burned areas on suppression effectiveness and avoided exposure: A case study of the Las Conchas Fire

    Science.gov (United States)

    Matthew P. Thompson; Patrick Freeborn; Jon D. Rieck; Dave Calkin; Julie W. Gilbertson-Day; Mark A. Cochrane; Michael S. Hand

    2016-01-01

    We present a case study of the Las Conchas Fire (2011) to explore the role of previously burned areas (wildfires and prescribed fires) on suppression effectiveness and avoided exposure. Methodological innovations include characterisation of the joint dynamics of fire growth and suppression activities, development of a fire line effectiveness framework, and...

  14. Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

    Science.gov (United States)

    Background Results from previous population studies showed that mortality rates from acute myocardial infarction and type-2 diabetes during the 1980s and 1990s in rural, agricultural counties of Minnesota, Montana, North and South Dakota, were higher in counties with a higher le...

  15. A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens.

    Science.gov (United States)

    Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Omari, Michael; Otu, Jacob; Gehre, Florian; de Jong, Bouke; Antonio, Martin

    2018-04-02

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana.

  16. Global GPS data analysis at the National Geodetic Survey

    Science.gov (United States)

    Kass, William G.; Dulaney, Robert L.; Griffiths, Jake; Hilla, Stephen; Ray, Jim; Rohde, James

    2009-03-01

    NOAA’s National Geodetic Survey (NGS) has been one of the Analysis Centers (ACs) of the International GNSS Service (IGS) since its inception in 1994. Solutions for daily GPS orbits and Earth orientation parameters are regularly contributed to the IGS Rapid and Final products, as well as solutions of weekly station positions. These solutions are combined with those of the other ACs and then the resultant IGS products are distributed to users. To perform these tasks, NGS has developed and refined the Program for the Adjustment of GPS EphemerideS (PAGES) software. Although PAGES has continuously evolved over the past 15 years, recent efforts have focused mostly on updating models and procedures to conform more closely to IGS and the International Earth Rotation Service (IERS) conventions. Details of our processing updates and demonstrations of the improvements will be provided.

  17. Long-term analytical prediction of geodetic satellites motion to centimeter accuracy

    Science.gov (United States)

    Kudryavtsev, S.

    Studies of motion of geodetic satellites like LAGEOS or ETALON help with solution of many actual problems of geodesy and geophysics, such as improving the Earth rotation parameters or measuring the variations in the geopotential expansion coefficients. Many of these tasks require processing of tracking measurements of passive geodetic satellites collected over a long intervals of time, up to several tens of years. In this case analytical integration methods are better applicable than numerical methods (the latter are usually used for accurate prediction of satellite motion over several days or so). An open issue is the accuracy of the available analytical prediction methods. It should be essentially increased to become compatible to the accuracy of the best laser measurements, i.e. to be to the order of 1 centimeter. This work presents the author's results obtained in solution of that ambitious task. A new analytical method for calculating satellite orbital perturbations due to different disturbing forces is developed. It is based on Poincare method of small parameter but takes advantages of modern high-performance computers and of tools of computer algebra. All perturbations proportional up to and including the fifth-order of small parameters are obtained. At present the method precisely calculates the effects of all geodynamical forces on satellite motion given by the most up-to-date IAU and IERS models, such as non-central Earth gravity potential, precession and nutation of the geoequator, polar motion and irregularities in the Earth's rotation, effect of ocean and solid Earth tides, pole tide, and secular variations of gravity coefficients. The relevant method's accuracy is proven to be equivalent to 1-2 centimeters (stable over one year at least) when calculating positions of high altitude geodetic satellites like ETALON. Recently the method is expanded by analytical calculation of luni-solar perturbations. For that a new high-precise harmonic development of

  18. On the potential of lunar observations in regular geodetic VLBI sessions

    Science.gov (United States)

    Klopotek, Grzegorz; Hobiger, Thomas; Haas, Rüdiger

    2017-04-01

    Artificial radio sources on the surface of the Moon enable us to observe lunar based transmitters with geodetic VLBI. Although during the last years a few dedicated VLBI experiments have already been carried out, the question still remains how and to what extend new information can be derived from observing such targets. Therefore, we perform Monte Carlo simulations using the c5++ software in order to evaluate how the inclusion of lunar observations into regular VLBI schedules would impact classical Earth-related target parameters of geodetic VLBI such as station coordinates and Earth Orientation Parameters, as well as how it would extend the possibilities to determine selenoidic parameters. Our study is based on modified IVS-R1 observing schedules, originally created by the International VLBI Service for Geodesy and Astrometry (IVS) to determine Earth Orientation Parameters, thus representing state-of-the-art VLBI observing programs. Based on our simulations, we demonstrate that an artificial radio source on the surface of the Moon can be located with both, accuracy and precision of better than 50 cm when observed along with quasars in the regular IVS-R1 session schedules. Moreover, we show that geodetic VLBI has the potential to improve our knowledge of lunar physical models and/or help to verify or update lunar ephemerides. We will discuss how the quality and quantity of lunar observations affect the uncertainty of the position of a non-moving artificial radio source located on the surface of the Moon and we highlight the factors limiting the determination of its position. Furthermore, we will reveal the impact of Moon VLBI observations on the determination of the Earth Orientation Parameters and VLBI station positions. We will also test the concept of VLBI lunar observations with simulations that reflect VGOS performance in terms of observation precision, number of scans and future network configurations. Thus, our simulations will provide valuable insights

  19. The impact of smoking and previous periodontal disease on peri-implant microbiota and health: a retrospective study up to 7-year follow-up.

    Science.gov (United States)

    Quaranta, Alessandro; Assenza, Bartolomeo; D'Isidoro, Orlando; Profili, Fabia; Polimeni, Antonella; Vozza, Iole

    2015-01-01

    To evaluate the impact of smoking and previous periodontal disease on peri-implant microbiota and health in medium to long-term maintained patients. A retrospective evaluation of partial edentulous patients restored with dental implants and enrolled in a regular supportive therapy was performed. Inclusion criteria were: medium to long-term periodontal and implant maintenance (at least 5 years), a minimum of 2 implants placed in each patient, absence of systemic diseases that may affect osseointegration. 30 implants in 15 patients were included in the study. Subjects were divided in smokers or non-smokers and between patients previously affected by periodontal disease and periodontally healthy. Peri-implant and periodontal parameters were assessed (PD,BoP, mPI). Microbiological samples were collected around implant and an adjacent tooth. Real- Time Polymerase Chain Reaction (RT-PCR) analysis was performed. In all the three groups no differences in bacterial counts between dental and implant sites were observed. Non smoker, healthy patients: healthy clinical parameters, significant counts of spirochetes in isolated patients. Non smokers with previous periodontal disease: occasional positive BoP values, significant high counts of pathogenic bacteria. Smokers with previous periodontal disease: clinical signs of inflammation including deep pockets and slight bone resorption, significant counts of pathogenic bacteria. Over a follow-up of 5 to 7 years, it is possible to state that the absence of smoking habit and previous periodontal disease positively influences the peri-implant microbiological and clinical conditions in partial edentulous patients restored with dental implants and enrolled in a strict regular supportive therapy.

  20. An Investigation of the Accuracy of Coulomb Stress Changes Inferred From Geodetic Observations Following Subduction Zone Earthquakes

    Science.gov (United States)

    Stressler, Bryan J.; Barnhart, William D.

    2017-09-01

    Earthquake clustering along plate boundaries suggests that earthquakes may interact, and static Coulomb stress change (CSC) is commonly invoked as one possible mechanism for stress transfer between earthquakes and nearby faults. Previous work has addressed the precision of CSC predictions that are influenced by observational noise, inversion regularization, and simplified modeling assumptions. Here we address the accuracy of CSC predictions informed by geodetic observations in subduction zones where inversion model resolution is poor. We conduct synthetic tests to quantify the degree to which the sign and magnitude of CSC can be reliably inferred from slip distributions inverted from various geodetic observations (interferometric synthetic aperture radar (InSAR), GPS, and seafloor observations). We find that in an idealized subduction zone, CSC can only be confidently inferred for receiver faults far (tens of kilometers) from the earthquake source, though this distance shortens with the addition of synthetic seafloor observations. We apply this methodology to the 2010 Mw8.8 Maule earthquake and identify 13 aftershocks from a population of 475 documented events for which we can confidently resolve coseismic stress changes. These results demonstrate that the low model resolution of fault slip inversions in subduction zones limits our ability to address fundamental questions about earthquake sources and stress interactions. Nonetheless, our results highlight that stress change predictions are considerably more accurate after the introduction of seafloor geodetic observations. Additionally, we show that InSAR observations are not required to substantially improve stress change approximations in regions where GPS may be the only viable observation, such as in island arcs settings.

  1. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study

    DEFF Research Database (Denmark)

    Schramm, Tina Ken; Gislason, Gunnar Hilmar; Vaag, Allan

    2011-01-01

    Aims The impact of insulin secretagogues (ISs) on long-term major clinical outcomes in type 2 diabetes remains unclear. We examined mortality and cardiovascular risk associated with all available ISs compared with metformin in a nationwide study. Methods and results All Danish residents >20 years......, initiating single-agent ISs or metformin between 1997 and 2006 were followed for up to 9 years (median 3.3 years) by individual-level linkage of nationwide registers. All-cause mortality, cardiovascular mortality, and the composite of myocardial infarction (MI), stroke, and cardiovascular mortality...... associated with individual ISs were investigated in patients with or without previous MI by multivariable Cox proportional-hazard analyses including propensity analyses. A total of 107 806 subjects were included, of whom 9607 had previous MI. Compared with metformin, glimepiride (hazard ratios and 95...

  2. Modeling and Analysis of Integrated Bathymetric and Geodetic Data for Inventory Surveys of Mining Water Reservoirs

    Science.gov (United States)

    Ochałek, Agnieszka; Lipecki, Tomasz; Jaśkowski, Wojciech; Jabłoński, Mateusz

    2018-03-01

    The significant part of the hydrography is bathymetry, which is the empirical part of it. Bathymetry is the study of underwater depth of waterways and reservoirs, and graphic presentation of measured data in form of bathymetric maps, cross-sections and three-dimensional bottom models. The bathymetric measurements are based on using Global Positioning System and devices for hydrographic measurements - an echo sounder and a side sonar scanner. In this research authors focused on introducing the case of obtaining and processing the bathymetrical data, building numerical bottom models of two post-mining reclaimed water reservoirs: Dwudniaki Lake in Wierzchosławice and flooded quarry in Zabierzów. The report includes also analysing data from still operating mining water reservoirs located in Poland to depict how bathymetry can be used in mining industry. The significant issue is an integration of bathymetrical data and geodetic data from tachymetry, terrestrial laser scanning measurements.

  3. The impact of using jason-1 and cryosat-2 geodetic mission altimetry for gravity field modeling

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Jain, Maulik; Knudsen, Per

    2016-01-01

    operating in a geodetic mission as part its end of life mission. In this presentation, we perform an investigation of the impact of the Cryosat-2 and Jason-1 geodetic missions on high resolution marine gravity field mapping through comparison with recent high quality marine gravity measured by the United...... States Naval Ship Bowditch in the Western Pacific Ocean in 2006. Comparisons of pre and post Cryosat- 2/Jason-1 gravity fields illustrated the importance of these new geodetic missions for altimeter marine gravity field mapping. Altimetric gravity derived using 1 year of either Cryosat-2 or Jason-1...

  4. IGSM Croatia 2010, International Geodetic Students Meeting, University of Zagreb, Faculty of Geodesy, Zagreb, 2010

    Directory of Open Access Journals (Sweden)

    Sandra Keran

    2010-06-01

    Full Text Available IGSM (International Geodetic Students Meeting is an international meeting of students from geodetic and similar faculties which has been held for 23 years. It all began with the Technical University students’ meeting in the Dutch city Delft which was held in order to compare programs of European geodetic faculties. About 150 students from 15 faculties and 7 countries replied to their invitation. Nowadays, the number of member countries exceeds 30 and countries outside Europe are also included. This informal students’ meeting has gained great importance over the years and its organisation has become more complicated.

  5. The UNAVCO role in planning, building, and maintaining geodetic infrastructure across the Americas: update on PBO, COCONet, and TLALOCNet

    Science.gov (United States)

    Mattioli, G. S.; Braun, J. J.; Cabral, E.; Calais, E.; DeMets, C.; Feaux, K.; Mencin, D.; Miller, M. M.; Normandeau, J.; Serra, Y.; Wang, G.

    2013-05-01

    UNAVCO maintains the NSF-funded Plate Boundary Observatory (PBO), which is the geodetic facility of EarthScope. PBO is largest continuous GPS and borehole geophysical network in the Americas, with ~1130 cGPS sites, including several with multiple monuments, ~80 boreholes, with 75 tensor strainmeters, 79 short-period, 3-component seismometers, and pore pressure sensors at 23 sites. PBO also includes 26 tiltmeters deployed at several volcanoes. Surface meteorological sensors are collocated at 134 GPS sites. UNAVCO provides high-rate (1 Hz), low-latency (Puerto Vallarta in 2010. The TLALOCNet plan calls for UNAVCO to install 9 new PBO-quality GPS-Met sites in Mexico and adjacent islands, upgrade 29 sites previously installed with NSF funding along the western subduction boundary, and coordinate with the Mexican National Meteorological Service to federate data from at least another 80 GPS-Met sites distributed across Mexico. All GPS-Met data from TLALOCNet will be freely available at the UNAVCO archive and Mexican mirror sites. The ultimate goal for these networks is to provide free, high-quality, low-latency data and data products for researchers, educators, students, and the private sector. Data from COCONet and TLALOCNet will be used by US and international scientists to study solid earth processes, for example plate kinematics and dynamic as well as plate boundary interactions and deformation, with an emphasis on the earthquake cycle. The networks also serve atmospheric science objectives by providing more precise estimates of tropospheric water vapor thus enabling better forecast of the dynamics of airborne moisture associated with the yearly Caribbean hurricane cycle.

  6. Risk for high depressive symptoms in diagnosed and previously undetected diabetes: 5-year follow-up results of the Heinz Nixdorf Recall study.

    Directory of Open Access Journals (Sweden)

    Andrea Icks

    Full Text Available OBJECTIVE: The objective of this study was to determine the risk for the development of high depressive symptoms in study participants with diagnosed and previously undetected diabetes mellitus compared to those without diabetes in a prospective population-based cohort study in Germany. METHODS: We estimated the 5-year cumulative incidence of high depressive symptoms in participants without high depressive symptoms at baseline (n = 3,633, 51.4% men, mean age (SD 59.1 (7.6 years, 7.0% diagnosed diabetes, 5.3% previously undetected diabetes from the population-based Heinz Nixdorf Recall study. Diabetes was assessed by self-report, medication, and blood glucose. High depressive symptoms were assessed using CES-D. We calculated odds ratios and their corresponding 95% confidence interval, using multiple logistic regression analyses. RESULT: Cumulative 5-year incidences (95% CI of high depressive symptoms in participants with diagnosed, undetected, and without diabetes were 7.1 (4.2-10.9, 4.1 (1.8-8.0, and 6.5 (5.6-7.4, respectively. The age-sex-adjusted OR for developing high depressive symptoms was 1.22 (0.74-2.03 in participants with diagnosed compared to those without diabetes, and 1.00 (0.59-1.68 after adjustment for BMI, physical activity, education, stroke, and myocardial infarction. The age-sex adjusted OR for developing high depressive symptoms in participants with previously undetected diabetes compared to those without diabetes was 0.72; 0.35-1.48; and fully adjusted 0.62; 0.30-1.30. CONCLUSION: We found no significant associations, maybe due to low power. However, our results are in line with a recent meta-analysis suggesting that risk of developing high depressive symptoms in patients with diagnosed diabetes may be moderately higher than in those without diabetes, and that comorbidity may explain in part this association. In participants with previously undetected diabetes, this first longitudinal study indicates that the risk is not

  7. Results from the Geodetic Observatory TIGO due to the Mw 8.8 Earthquake

    Science.gov (United States)

    Hase, H.; Böer, A.; Sierk, B.; Ihde, J.; Weber, G.; Wilmes, H.; Falk, R.; Hessels, U.; Neumaier, P.; Söhne, W.; Wziontek, H.; Engelhard, G.; Sobarzo, S.; Cifuentes, O.; Guaitiao, C.; Cona, I.; Avendaño, M.; Herrera, C.; Mora, V.; Fernandez, A.; Oñate, E.; Zaror, P.; Pedreros, F.; Zapata, O.

    2010-12-01

    The Geodetic Observatory TIGO is unique in Latin America. With its sensors and instruments it defines a reference point in the time, space and gravity field domain. Its operation started in 2002, for which reason data series documented the preseismic situation very well. With the Mw 8.8 earthquake on February 27, 2010, the entire observatory was exposed to strong motions due to its closeness to the epicenter. Since then the postseismic behaviour of the subduction zone can be studied and compared with the preseismic situation. TIGO provided continuous GPS/GLONASS data with 1s samples which give an insight to the mechanism of the decoupling of the Nazca and the South-American plate. The displacement of more than 3m had a duration of 30s at the beginning of the 147s duration of the earthquake. The displacement could be confirmed afterwards with VLBI and SLR methods. TIGO used its absolute gravity meter in an unusual way with weekly measurements on the same monument. These data show an irregularity during the last 3 weeks before the earthquake. Finally the postseismic movement to the west triggered by the earthquake and registered by geodetic space techniques indicate that the western expansion of the South-American plate did not stop yet. The pre- and post-seismic displacement vectors differ by less than 180° which might be explained by a fractional strike slip in the mega thrust. The coincidence of the epicenter with one of the keystations for global reference frames showed deficiencies by the linear modelling of tectonical movements in terrestial reference frames. This problem calls for near-real time reference frames.

  8. Incorporating GPS geodetic data into the undergraduate classroom to improve data and information literacy

    Science.gov (United States)

    Jansma, P. E.; Mattioli, G. S.

    2002-12-01

    As part of an NSF-funded project, we are incorporating Global Positioning System (GPS) geodesy into the classroom to improve data and information literacy among undergraduate students. Our objectives are: to introduce statistical concepts essential for the interpretation of large datasets; to promote communication skills; to enhance critical thinking; and to build teamwork. GPS geodesy is ideal for illustrating data literacy concepts. Data precision and accuracy depend upon several factors, including type of equipment, environmental conditions, length of occupations, monument design, site location, configuration of the geodetic network, and processing strategies. All of these can be varied, allowing the students to learn the trade-offs among cost, time, and quality and to determine the most efficient methodology for specific problems. In addition, precision, accuracy, and errors govern the interpretations that can be made and the potential to distinguish among competing models. Our focus is a semester-long course that uses GPS geodesy in real-world applications and also requires integration of GPS data into oral presentations and written reports. Students work in teams on "cases" that pose hypotheses for testing. The cases are derived from our on-going research projects and take advantage of on-line continuous GPS (CGPS) data as well as our archived campaign data. The case studies are: 1) Microplate tectonics in the northeastern Caribbean; 2) Inflation/deflation cycles of the Soufriere Hills volcano, Montserrat; and 3) Contribution of monument instability to the overall error in geodetic data from the New Madrid Seismic Zone. All course materials will be on-line and available for the community.

  9. Comparison of time until elective intestinal resection regarding previous anti-tumor necrosis factor exposure: a Brazilian study on patients with Crohn's disease

    Directory of Open Access Journals (Sweden)

    Paulo Gustavo Kotze

    2018-01-01

    Full Text Available Background/Aims: The use of anti-tumor necrosis factor (anti-TNF agents seems to reduce surgical rates and delay surgical procedures in prospective trials and population-based studies in the management of Crohn's disease (CD. This study aimed to identify whether preoperative anti-TNF agents influence the time from diagnosis to surgery. Methods: An observational retrospective cohort study was conducted on patients with CD submitted to intestinal resections due to complications or medical therapy failure in a period of 7 years. The patients were allocated into 2 groups according to their previous exposure to anti-TNF agents in the preoperative period. Epidemiological aspects regarding age at diagnosis, smoking, perianal disease, and preoperative conventional therapy were considered. A Kaplan-Meier survival analysis was used to outline possible differences between the groups regarding the time to surgery. Results: A total of 123 patients were included (71 and 52 with and without previous exposure to biologics, respectively. The overall time to surgery was 108±6.9 months (maximum, 276 months. The survival estimation revealed no difference in the mean time to intestinal resection between the groups (99.78±10.62 months in the patients without and 114.01±9.07 months in those with previous anti-TNF use (log-rank P=0.35. There was no significant difference in the time to surgery regarding perianal CD (P=0.49, smoking (P=0.63, preoperative azathioprine (P=0.073 and steroid use (P=0.58. Conclusions: The time from diagnosis to surgery was not influenced by the preoperative use of anti-TNF therapy in this cohort of patients.

  10. Food intake during the previous 24 h as a percentage of usual intake: a marker of hypoxia in infants with bronchiolitis: an observational, prospective, multicenter study

    Directory of Open Access Journals (Sweden)

    Corrard François

    2013-01-01

    Full Text Available Abstract Background Hypoxia associated with bronchiolitis is not always easy to assess on clinical grounds alone. The aim of this study was to determine the value of food intake during the previous 24 hours (bottle and spoon feeding, as a percentage of usual intake (24h FI, as a marker of hypoxia, and to compare its diagnostic value with that of usual clinical signs. Methods In this observational, prospective, multicenter study, 18 community pediatricians, enrolled 171 infants, aged from 0 to 6 months, with bronchiolitis (rhinorrhea + dyspnea + cough + expiratory sounds. Infants with risk factors (history of prematurity, chronic heart or lung disorders, breast-fed infants, and infants having previously been treated for bronchial disorders were excluded. The 24h FI, subcostal, intercostal, supracostal retractions, nasal flaring, respiratory rate, pauses, cyanosis, rectal temperature and respiratory syncytial virus test results were noted. The highest stable value of transcutaneous oxygen saturation (SpO2 was recorded. Hypoxia was noted if SpO2 was below 95% and verified. Results 24h FI ≥ 50% was associated with a 96% likelihood of SpO2 ≥ 95% [95% CI, 91–99]. In univariate analysis, 24h FI  Conclusion In practice, the measure of 24 h FI may be useful in identifying hypoxia and deserves further study.

  11. Accuracy of preoperative real-time dynamic transvaginal ultrasound sliding sign in prediction of pelvic adhesions in women with previous abdominopelvic surgery: prospective, multicenter, double-blind study.

    Science.gov (United States)

    Ayachi, A; Bouchahda, R; Derouich, S; Mkaouer, L; Kehila, M; Abouda, H; Channoufi, B; Bouyahia, M; Braham, M; Zhioua, F; Bouchahda, H; Mourali, M

    2018-02-01

    To investigate the role of the transvaginal sonographic (TVS) sliding sign in predicting pelvic adhesions in women with previous abdominopelvic surgery. This was a multicenter, prospective, interventional, double-blind study of patients with a history of abdominopelvic surgery who were undergoing laparoscopy or laparotomy during the 6-month period from March to August 2016 in one of three academic obstetrics and gynecology departments. Prior to surgery, patients were examined by TVS to assess the vesicouterine pouch, uterus, ovaries and pouch of Douglas, using the TVS pelvic sliding sign. Ultrasound findings and medical and surgical data were recorded. We assessed the accuracy of the preoperative TVS sliding sign in the prediction of pelvic adhesions overall and in each compartment separately. During the study period, complete TVS sliding sign and laparoscopic or laparotomic data were available for 107 women. Their mean age was 44.0 (95% CI, 41.6-46.4; range, 20-79) years. Their mean parity was 2.0 (95% CI, 1.7-2.3; range, 0-9) and the mean number of previous abdominal surgical procedures per patient was 1.3 (95% CI, 1.2-1.5; range, 1-4). Adhesions were noted in 27/107 (25.2%) patients. The TVS sliding sign had a sensitivity of 96.3% and specificity of 92.6% in predicting pelvic adhesions. There was a significant relationship between adhesions in each compartment and the TVS sliding sign (P sign is an effective means to detect preoperatively pelvic adhesions in patients with previous abdominopelvic surgery. Use of such a non-invasive and well-tolerated technique could help in the planning of laparoscopy or laparotomy and counseling of these patients. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

  12. The contribution of previous lameness events and body condition score to the occurrence of lameness in dairy herds: A study of 2 herds.

    Science.gov (United States)

    Randall, L V; Green, M J; Green, L E; Chagunda, M G G; Mason, C; Archer, S C; Huxley, J N

    2018-02-01

    It has been demonstrated that low body condition and previous occurrence of lameness increase the risk of future lameness in dairy cows. To date the population attributable fraction (PAF), which provides an estimate of the contribution that a risk factor makes toward the total number of disease events in a population, has not been explored for lameness using longitudinal data with repeated measures. Estimation of PAF helps to identify control measures that could lead to the largest improvements on-farm. The aim of this study was to use longitudinal data to evaluate the proportion of lameness that could be avoided in 2 separate herds (2 populations) through (1) reduced recurrence of previous lameness events, (2) and moving body condition score (BCS) into more optimal ranges. Data were obtained from 2 UK dairy herds: herd A, a 200-cow herd with 8 yr of data from a total of 724 cows where lameness events were based on weekly locomotion scores (LS; 1 to 5 scale), and herd B, a 600-cow herd with data recorded over 44 mo from a total of 1,040 cows where treatment of clinical cases was used to identify lameness events. The PAF for categories of BCS were estimated using a closed equation appropriate for multiple exposure categories. Simulation models were used to explore theoretical scenarios to reflect changes in BCS and recurrence of previous lameness events in each herd. For herd A, 21.5% of the total risk periods (cow-weeks) contained a lameness event (LS 3, 4, or 5), 96% of which were repeat events and 19% were recorded with BCS events were based on 2 consecutive weeks of LS 4 or 5, 4% of risk periods were recorded as lame, of which 89.5% were repeat events. For herd B, 16.3% of the total risk periods (consecutive 30 d) contained a lameness event (72.6% were repeat events) and 20% were recorded with BCS ≤2 (0 to 120 d previously). The median PAF for all previous lameness was between 79 and 83% in the 2 herds. Between 9 and 21% of lameness events could be attributed

  13. A pilot study of a metronomic chemotherapy regimen with weekly low-dose docetaxel for previously treated non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Yokoi T

    2012-05-01

    Full Text Available Takashi Yokoi, Takeshi Tamaki, Toshiki Shimizu, Shosaku NomuraFirst Department of Internal Medicine, Kansai Medical University, Moriguchi City, Osaka, JapanBackground: Low-dose metronomic (LDM chemotherapy is a novel approach that involves frequent administration of a low dose of chemotherapeutic agent without a long interval.Purpose: The aim of this clinical pilot study was to evaluate the toxicity and efficacy of LDM chemotherapy with weekly low-dose docetaxel for previously treated non-small cell lung cancer (NSCLC.Patients and methods: The enrolled patients received 15 mg/m2 of docetaxel intravenously on a weekly basis without any interval.Results: Twenty-seven patients were enrolled in the study; 20 were men, and seven were women. The median age was 62 years (range: 32–75. Eleven patients were stage IIIB, and 16 were stage IV. The Eastern Cooperative Oncology Group performance status was 0 or 1. There was no severe hematological adverse effect; importantly, there was no neutropenia or thrombocytopenia. The objective response rate was 7.4% and the disease control rate was 51.9%. The median survival time was 16.4 months (95% CI: 5.7–36.4.Conclusion: Our preliminary results indicate that our metronomic regimen was well tolerated and active in patients with previously treated NSCLC. Thus, further investigation of this LDM regimen is warranted.Keywords: optimal biological dose, metronomic chemotherapy, docetaxel

  14. Outcome of secondary high-grade glioma in children previously treated for a malignant condition: A study of the Canadian Pediatric Brain Tumour Consortium

    International Nuclear Information System (INIS)

    Carret, Anne-Sophie; Tabori, Uri; Crooks, Bruce; Hukin, Juliette; Odame, Isaac; Johnston, Donna L.; Keene, Daniel L.; Freeman, Carolyn; Bouffet, Eric

    2006-01-01

    Background and purpose: Reports of secondary high-grade glioma (HGG) in survivors of childhood cancer are scarce. The aim of this study was to review the pattern of diagnosis, the treatment, and outcome of secondary pediatric HGG. Patients and methods: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC). Results: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n = 9) or solid tumour (n = 9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months. Conclusion: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours

  15. Does using testicular sperm retrieval rather than ejaculated spermatozoa improve reproductive outcomes in couples with previous ART failure and poor ovarian response? A case-controlled study.

    Science.gov (United States)

    Gilman, A R; Younes, G; Tannus, S; Son, W Y; Chan, P; Buckett, W

    2018-01-01

    The objective of this study was to assess whether testicular-retrieved spermatozoa improve reproductive outcomes compared to fresh ejaculate in women with poor ovarian response and a history of previous ART failure. The study was performed as a retrospective case-control study at a university-based reproductive center in Montreal, Quebec, Canada. Eighteen poor-responder patients were matched 3 : 1 with 54 controls. Poor responders were defined as those with ≤3 oocytes retrieved at oocyte pickup. Cases were identified as poor responders, and only those with previous IVF failure(s) as an indication for testicular-retrieved spermatozoa were included. Controls were age and cycle attempt number matched. All patients were included only once. From January 1, 2009 to December 31, 2015, all patients and controls underwent an IVF cycle using ICSI with either testicular spermatozoa or ejaculated spermatozoa, respectively. Outcomes included live birth rate, pregnancy rate, miscarriage rate, oocyte number, and embryo transfer (ET) day. The results showed live birth rates, pregnancy rates, and miscarriage rates were similar. There were fewer day 2 ETs (8.5% vs. 48.6%, p = 0.01) and more day 5 blastocyst transfers (25.0% vs. 5.4%, p = 0.05) in the testicular sperm retrieval group compared to controls and thus an overall suggestion of better embryo quality in the testicular sperm group. Overall, however, the use of testicular sperm retrieval appears to add little. Women with poor ovarian response typically have a poor prognosis with respect to live birth rates, and this is further supported in this study. The suggestion of better embryo quality in the testicular-retrieved sperm group would need to be further assessed in a larger multicentered study. © 2017 American Society of Andrology and European Academy of Andrology.

  16. Geodetic and geophysical observations in Antarctica an overview in the IPY perspective

    CERN Document Server

    Capra, Alessandro

    2008-01-01

    This book is a collection of papers on various aspects of the geodetic and geophysical investigation and observation techniques. It includes material from the Arctic and Antarctica, as well as covering work from both temporary and permanent observatories.

  17. 2011 NOAA National Geodetic Survey (NGS) LIDAR of North Carolina: Hurricane Irene Emergency Response Mapping Product

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data were collected by the National Oceanic Atmospheric Administration National Geodetic Survey Remote Sensing Division using a Riegl Q680i-D system. The data...

  18. 2011 NOAA National Geodetic Survey (NGS) Lidar: Great Bay and Portsmouth Harbor, New Hampshire

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data were collected by the National Oceanic Atmospheric Administration National Geodetic Survey Remote Sensing Division using a Riegl Q680i-D system. The data...

  19. Geodetic Framework for Martian Satellite Exploration II: Astrometry; Phobos Geodetic Control and Maps

    Science.gov (United States)

    Willner, K.; Burmeister, S.; Ziese, R.; Oberst, J.; Wählisch, M.

    2017-09-01

    Phobos, the larger of the two Martian moons is currently of great interest to the science community. While there were several Phobos mission proposals in the scope of NASA's discovery program, ESA and Roscosmos are currently studying the feasibility of a sample return mission [4], the Japanese space Agency plans to launch a sample return mission by 2024 [5], and ESA's M5 call received a mission proposal to explore the Martian moons [6]. Following the successful launch in 2003, ESA's Mars Express Mission (MEX) moves in an orbit, which has close encounters of Phobos on a regular basis, favorable for Phobos observations. Here we report on current activities of Phobos research in the various fields of interest based on image data of the High Resolution Stereo Camera on-board the MEX spacecraft.

  20. Vitamin D deficiency in medical patients at a central hospital in Malawi: a comparison with TB patients from a previous study.

    Directory of Open Access Journals (Sweden)

    Yamikani Mastala

    Full Text Available OBJECTIVES: To determine the prevalence of vitamin D deficiency (VDD in adult medical, non-tuberculous (non-TB patients. To investigate associations with VDD. To compare the results with a similar study in TB patients at the same hospital. DESIGN: Cross-sectional sample. SETTING: Central hospital in Malawi. PARTICIPANTS: Adult non-TB patients (n = 157, inpatients and outpatients. OUTCOME MEASURES: The primary outcome was the prevalence of VDD. Potentially causal associations sought included nutritional status, in/outpatient status, HIV status, anti-retroviral therapy (ART and, by comparison with a previous study, a diagnosis of tuberculosis (TB. RESULTS: Hypovitaminosis D (≤75 nmol/L occurred in 47.8% (75/157 of patients, 16.6% (26/157 of whom had VDD (≤50 nmol/L. None had severe VDD (≤25 nmol/L. VDD was found in 22.8% (23/101 of in-patients and 5.4% (3/56 of out-patients. In univariable analysis in-patient status, ART use and low dietary vitamin D were significant predictors of VDD. VDD was less prevalent than in previously studied TB patients in the same hospital (68/161 = 42%. In multivariate analysis of the combined data set from both studies, having TB (OR 3.61, 95%CI 2.02-6.43 and being an in-patient (OR 2.70, 95%CI 1.46-5.01 were significant independent predictors of VDD. CONCLUSIONS: About half of adult medical patients without TB have suboptimal vitamin D status, which is more common in in-patients. VDD is much more common in TB patients than non-TB patients, even when other variables are controlled for, suggesting that vitamin D deficiency is associated with TB.

  1. Reduced live-birth rates after IVF/ICSI in women with previous unilateral oophorectomy: results of a multicentre cohort study.

    Science.gov (United States)

    Lind, Tekla; Holte, Jan; Olofsson, Jan I; Hadziosmanovic, Nermin; Gudmundsson, Johannes; Nedstrand, Elizabeth; Lood, Mikael; Berglund, Lars; Rodriguez-Wallberg, Kenny

    2018-02-01

    Is there a reduced live-birth rate (LBR) after IVF/ICSI treatment in women with a previous unilateral oophorectomy (UO)? A significantly reduced LBR after IVF/ICSI was found in women with previous UO when compared with women with intact ovaries in this large multicentre cohort, both crudely and after adjustment for age, BMI, fertility centre and calendar period and regardless of whether the analysis was based on transfer of embryos in the fresh cycle only or on cumulative results including transfers using frozen-thawed embryos. Similar pregnancy rates after IVF/ICSI have been previously reported in case-control studies and small cohort studies of women with previous UO versus women without ovarian surgery. In all previous studies multiple embryos were transferred. No study has previously evaluated LBR in a large cohort of women with a history of UO. This research was a multicentre cohort study, including five reproductive medicine centres in Sweden: Carl von Linné Clinic (A), Karolinska University Hospital (B), Uppsala University Hospital (C), Linköping University Hospital (D) and Örebro University Hospital (E). The women underwent IVF/ICSI between January 1999 and November 2015. Single embryo transfer (SET) was performed in approximately 70% of all treatments, without any significant difference between UO exposed women versus controls (68% versus 71%), respectively (P = 0.32), and a maximum of two embryos were transferred in the remaining cases. The dataset included all consecutive treatments and fresh and frozen-thawed cycles. The exposed cohort included 154 women with UO who underwent 301 IVF/ICSI cycles and the unexposed control cohort consisted of 22 693 women who underwent 41 545 IVF/ICSI cycles. Overall, at the five centres (A-E), the exposed cohort underwent 151, 34, 35, 41 and 40 treatments, respectively, and they were compared with controls of the same centre (18 484, 8371, 5575, 4670 and 4445, respectively). The primary outcome was LBR, which was

  2. Everolimus Plus Exemestane in Advanced Breast Cancer: Safety Results of the BALLET Study on Patients Previously Treated Without and with Chemotherapy in the Metastatic Setting.

    Science.gov (United States)

    Generali, Daniele; Montemurro, Filippo; Bordonaro, Roberto; Mafodda, Antonino; Romito, Sante; Michelotti, Andrea; Piovano, Pierluigi; Ionta, Maria Teresa; Bighin, Claudia; Sartori, Donata; Frassoldati, Antonio; Cazzaniga, Marina Elena; Riccardi, Ferdinando; Testore, Franco; Vici, Patrizia; Barone, Carlo Antonio; Schirone, Alessio; Piacentini, Federico; Nolè, Franco; Molino, Annamaria; Latini, Luciano; Simoncini, Edda Lucia; Roila, Fausto; Cognetti, Francesco; Nuzzo, Francesco; Foglietta, Jennifer; Minisini, Alessandro Marco; Goffredo, Francesca; Portera, Giuseppe; Ascione, Gilda; Mariani, Gabriella

    2017-06-01

    The BALLET study was an open-label, multicenter, expanded access study designed to allow treatment with everolimus plus exemestane in postmenopausal women with hormone receptor-positive metastatic breast cancer progressed following prior endocrine therapy. A post hoc analysis to evaluate if previous chemotherapy in the metastatic setting affects the safety profile of the combination regimen of everolimus and exemestane was conducted on the Italian subset, as it represented the major part of the patients enrolled (54%). One thousand one hundred and fifty-one Italian patients were included in the present post hoc analysis, which focused on two sets of patients: patients who never received chemotherapy in the metastatic setting (36.1%) and patients who received at least one chemotherapy treatment in the metastatic setting (63.9%). One thousand one hundred and sixteen patients (97.0%) prematurely discontinued the study drug, and the main reasons reported were disease progression (39.1%), local reimbursement of everolimus (31.1%), and adverse events (AEs) (16.1%). The median duration of study treatment exposure was 139.5 days for exemestane and 135.0 days for everolimus. At least one AE was experienced by 92.5% of patients. The incidence of everolimus-related AEs was higher (83.9%) when compared with those that occurred with exemestane (29.1%), and the most commonly reported everolimus-related AE was stomatitis (51.3%). However, no significant difference in terms of safety related to the combination occurred between patients without and with chemotherapy in the metastatic setting. Real-life data of the Italian patients BALLET-related cohort were an adequate setting to state that previous chemotherapy did not affect the safety profile of the combination regimen of everolimus and exemestane. With the advent of new targeted agents for advanced or metastatic breast cancer, multiple lines of therapy may be possible, and components of the combined regimens can overlap from

  3. Higher frequency of hamstring injuries in elite track and field athletes who had a previous injury to the ankle - a 17 years observational cohort study.

    Science.gov (United States)

    Malliaropoulos, Nikolaos; Bikos, Georgios; Meke, Maria; Vasileios, Korakakis; Valle, Xavier; Lohrer, Heinz; Maffulli, Nicola; Padhiar, Nat

    2018-01-01

    Inversion injury to the ankle and hamstring injuries are common problems in most sports. It is not known whether these injuries constitute a predisposing factor or a precursor of injury or re-injury of these anatomical locations. Therefore, we wished to test the hypothesis that a previous inversion ankle injury exerted a significant effect on the chance of an athlete suffering from a subsequent ipsilateral hamstring injury and vice versa. In an observational cohort study over 17 years (1998-2015), 367 elite track and field athletes, were grouped according to their first traumatic isolated ankle or hamstring injury. Fifty athletes experienced both injuries. The Mann-Whitney U and Chi-square tests ( p  < 0.05) were performed to test possible associations of ankle and hamstring injury with age, gender, athletics discipline, grade, and type of antecedent injury. Athletes with a preceding ankle injury had a statistically significantly higher chance of experiencing a subsequent hamstring injury compared with athletes who had experienced a hamstring injury as their first traumatic event (x 2  = 4.245, p  = 0.039). The proportion of both ankle and hamstring injury events was not statistically different between female (18%) and male (11%) athletes. Age and grade of injury did not influence the proportion of ankle and/or hamstring injury events. There is a statistically significantly higher frequency of hamstring injuries in elite track and field athletes having experienced a previous ankle ligament injury.

  4. Geodetic Inversion Analysis Method of Coseismic Slip Distribution Using a Three-dimensional Finite Element High-fidelity Model

    Science.gov (United States)

    Agata, R.; Ichimura, T.; Hirahara, K.; Hori, T.; Hyodo, M.; Hori, M.

    2013-12-01

    Many studies have focused on geodetic inversion analysis method of coseismic slip distribution with combination of observation data of coseismic crustal deformation on the ground and simplified crustal models such like analytical solution in elastic half-space (Okada, 1985). On the other hand, displacements on the seafloor or near trench axes due to actual earthquakes has been observed by seafloor observatories (e.g. the 2011 Tohoku-oki Earthquake (Tohoku Earthquake) (Sato et. al. 2011) (Kido et. al. 2011)). Also, some studies on tsunamis due to the Tohoku Earthquake indicate that large fault slips near the trench axis may have occurred. Those facts suggest that crustal models considering complex geometry and heterogeneity of the material property near the trench axis should be used for geodetic inversion analysis. Therefore, our group has developed a mesh generation method for finite element models of the Japanese Islands of higher fidelity and a fast crustal deformation analysis method for the models. Degree-of-freedom of the models generated by this method is about 150 million. In this research, the method is extended for inversion analyses of coseismic slip distribution. Since inversion analyses need computation of hundreds of slip response functions due to a unit fault slip assigned for respective divided cells on the fault, parallel computing environment is used. Plural crustal deformation analyses are simultaneously run in a Message Passing Interface (MPI) job. In the job, dynamic load balancing is implemented so that a better parallel efficiency is obtained. Submitting the necessary number of serial job of our previous method is also possible, but the proposed method needs less computation time, places less stress on file systems, and allows simpler job management. A method for considering the fault slip right near the trench axis is also developed. As the displacement distribution of unit fault slip for computing response function, 3rd order B

  5. A longitudinal study of relationships between previous academic achievement, emotional intelligence and personality traits with psychological health of medical students during stressful periods.

    Science.gov (United States)

    Yusoff, Muhamad Saiful Bahri; Esa, Ab Rahman; Mat Pa, Mohamad Najib; Mey, See Ching; Aziz, Rosniza Abdul; Abdul Rahim, Ahmad Fuad

    2013-01-01

    There is considerable evidence that emotional intelligence, previous academic achievement (i.e. cumulative grade point average (GPA)) and personality are associated with success in various occupational settings. This study evaluated the relationships of these variables with psychological health of first year medical students during stressful periods. A 1-year prospective study was done with students accepted into the School of Medical Sciences, Universiti Sains Malaysia. Information on emotional intelligence, GPA and personality traits were obtained prior to admission. The validated Universiti Sains Malaysia Emotional Quotient Inventory and Universiti Sains Malaysia Personality Inventory were used to measure emotional intelligence and personality traits, respectively. Stress, anxiety and depression were measured by the 21-item Depression Anxiety Stress Scale during the end-of-course (time 1) and final (time 2) examinations. At the less stressful period (time 1), stress level was associated with agreeableness and the final GPA, anxiety level was associated with emotional control and emotional conscientiousness and depression level was associated with the final GPA and extraversion. At the more stressful period (time 2), neuroticism associated with stress level, anxiety level was associated with neuroticism and emotional expression, and depression level was associated with neuroticism. This study found that neuroticism was the strongest associated factor of psychological health of medical students during their most stressful testing period. Various personality traits, emotional intelligence and previous academic performance were associated factors of psychological health during a less stressful period. These data suggest that early identification of medical students who are vulnerable to the stressful environment of medical schools might help them maintain psychological well-being during medical training.

  6. A COMPARATIVE STUDY OF PERINATAL OUTCOME IN WOMEN WITH RECURRENT PREECLAMPSIA TO WOMEN WITH PRE-ECLAMPSIA WHO WERE NORMOTENSIVE DURING THEIR PREVIOUS PREGNANCIES

    Directory of Open Access Journals (Sweden)

    Beena Guhan

    2016-08-01

    Full Text Available BACKGROUND AND OBJECTIVE Pre-eclampsia is a systemic syndrome that occurs in 3-5% of the pregnant women and is the leading cause of maternal/neonatal morbidity and mortality. We designed a study to compare perinatal outcome in women with recurrent preeclampsia to women with women with pre-eclampsia who were normotensive during their previous pregnancies. MATERIALS AND METHODS This study was conducted in Dept. of Obstetrics and Gynaecology, Institute of Maternal and Child Health, Government Medical College, Kozhikode for a period of 1 year from March 2013 to February 2014. We conducted this study in multiparous women who developed pre-eclampsia in index pregnancy (n=110. Among these, women who had pre-eclampsia in previous pregnancies (n=55 were compared to those who remained normotensive during their prior pregnancies (n=55. Maternal and foetal variables were compared. Multivariate logistic analyses were performed to examine the impact of pre-eclampsia on foetal outcome, preterm delivery, IUGR, still births adjusted for confounding variables. RESULTS No statistical significant difference was observed between the 2 groups in terms of age, gravida, parity. Women who experienced recurrent pre-eclampsia were at elevated risk for early onset of pre-eclampsia, deranged laboratory investigations (Hepatic and Renal parameters, Coagulation Profile, higher chances of maternal complications, foetal mortality and morbidity (Statistically significant P <0.05. Foetal loss was higher in women with recurrent pre-eclampsia (14.5% than in women with pre-eclampsia who had normotensive pregnancy history (1.8%. CONCLUSION Women with recurrent pre-eclampsia had a higher rate of perinatal loss compared to women with pre-eclampsia who were normotensive in their prior pregnancies.

  7. Azimuth selection for sea level measurements using geodetic GPS receivers

    Science.gov (United States)

    Wang, Xiaolei; Zhang, Qin; Zhang, Shuangcheng

    2018-03-01

    Based on analysis of Global Positioning System (GPS) multipath signals recorded by a geodetic GPS receiver, GPS Reflectometry (GPS-R) has demonstrated unique advantages in relation to sea level monitoring. Founded on multipath reflectometry theory, sea level changes can be measured by GPS-R through spectral analysis of recorded signal-to-noise ratio data. However, prior to estimating multipath parameters, it is necessary to define azimuth and elevation angle mask to ensure the reflecting zones are on water. Here, a method is presented to address azimuth selection, a topic currently under active development in the field of GPS-R. Data from three test sites: the Kachemak Bay GPS site PBAY in Alaska (USA), Friday Harbor GPS site SC02 in the San Juan Islands (USA), and Brest Harbor GPS site BRST in Brest (France) are analyzed. These sites are located in different multipath environments, from a rural coastal area to a busy harbor, and they experience different tidal ranges. Estimates by the GPS tide gauges at azimuths selected by the presented method are compared with measurements from physical tide gauges and acceptable correspondence found for all three sites.

  8. Geodetic determinations for the NuMI project at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Bocean, V. [Fermi National Accelerator Lab., Batavia, IL (United States)

    1999-07-01

    As a part of the Neutrinos at the Main Injector (NuMI) project, the MINOS (Main Injector Neutrino Oscillation Search) experiment will search for neutrino mass by looking for neutrino oscillations. The project plans to direct a beam of muon neutrinos from the Main Injector towards both nearby and far-off detectors capable of counting all three types of neutrinos. The beam will travel 735 km through the Earth towards a remote iron mine in northern Minnesota where, 710 m below surface, a massive 5400 metric tons detector will be built. For the neutrino energy spectrum physics test to work properly, the primary proton beam must be within {+-} 12 m from its ideal position at Soudan, MN, corresponding to {+-} 1.63 x 10-5 radians, i.e. 3.4 arc-seconds. Achieving this tolerance requires a rather exact knowledge of the geometry of the beam, expressed in terms of the azimuth and the slope of the vector joining the two sites. This paper summarizes the concepts, the methodology, the implementation, and the results of the geodetic surveying efforts made up to date for determining the absolute positions of the Fermilab and the Soudan underground mine sites, from which the beam orientation parameters are computed. (author)

  9. An efficient algorithm for geocentric to geodetic coordinate conversion

    Energy Technology Data Exchange (ETDEWEB)

    Toms, R.M.

    1995-09-01

    The problem of performing transformations from geocentric to geodetic coordinates has received an inordinate amount of attention in the literature. Numerous approximate methods have been published. Almost none of the publications address the issue of efficiency and in most cases there is a paucity of error analysis. Recently there has been a surge of interest in this problem aimed at developing more efficient methods for real time applications such as DIS. Iterative algorithms have been proposed that are not of optimal efficiency, address only one error component and require a small but uncertain number of relatively expensive iterations for convergence. In this paper a well known rapidly convergent iterative approach is modified to eliminate intervening trigonometric function evaluations. A total error metric is defined that accounts for both angular and altitude errors. The initial guess is optimized to minimize the error for one iteration. The resulting algorithm yields transformations correct to one centimeter for altitudes out to one million kilometers. Due to the rapid convergence only one iteration is used and no stopping test is needed. This algorithm is discussed in the context of machines that have FPUs and legacy machines that utilize mathematical subroutine packages.

  10. Geodetic determinations for the NuMI project at Fermilab

    International Nuclear Information System (INIS)

    Bocean, V.

    1999-01-01

    As a part of the Neutrinos at the Main Injector (NuMI) project, the MINOS (Main Injector Neutrino Oscillation Search) experiment will search for neutrino mass by looking for neutrino oscillations. The project plans to direct a beam of muon neutrinos from the Main Injector towards both nearby and far-off detectors capable of counting all three types of neutrinos. The beam will travel 735 km through the Earth towards a remote iron mine in northern Minnesota where, 710 m below surface, a massive 5400 metric tons detector will be built. For the neutrino energy spectrum physics test to work properly, the primary proton beam must be within ± 12 m from its ideal position at Soudan, MN, corresponding to ± 1.63 x 10-5 radians, i.e. 3.4 arc-seconds. Achieving this tolerance requires a rather exact knowledge of the geometry of the beam, expressed in terms of the azimuth and the slope of the vector joining the two sites. This paper summarizes the concepts, the methodology, the implementation, and the results of the geodetic surveying efforts made up to date for determining the absolute positions of the Fermilab and the Soudan underground mine sites, from which the beam orientation parameters are computed. (author)

  11. Prevalence of high-risk human papillomavirus and cervical intraepithelial neoplasias in a previously unscreened population--a pooled analysis from three studies.

    Science.gov (United States)

    Basu, Partha; Mittal, Srabani; Bhaumik, Suchismita; Mandal, Shyam Sunder; Samaddar, Anusree; Ray, Chinmayi; Siddiqi, Maqsood; Biswas, Jaydip; Sankaranarayanan, Rengaswamy

    2013-04-01

    Population prevalence of human papillomavirus (HPV) and cervical intraepithelial neoplasias (CIN) is an important indicator to judge the disease burden in the community, to monitor the performance of cervical cancer screening program and to assess the impact of HPV vaccination program. India being a country without any cervical cancer screening program has no published data on the population prevalence of CIN and only a few large community-based studies to report the high-risk HPV prevalence. The objective of our study was to study HPV and CIN prevalence in a previously unscreened population. We pooled together the results of three research studies originally designed to assess the performance of visual inspection after acetic acid application and Hybrid Capture 2 (HC 2). Nearly 60% of the screened women had colposcopy irrespective of their screening test results. The diagnosis and grading of cervical neoplasias were based on histology. The age standardized prevalence of HPV by HC 2 test was 6.0%. Age-adjusted prevalence of CIN1 and CIN2 was 2.3% and 0.5%, respectively. The age-adjusted prevalence of CIN3 was 0.4% and that of invasive cancer was 0.2%. The prevalence of high-risk HPV was relatively low in the population we studied, which is reflected in the low prevalence of high-grade CIN. The prevalence of CIN3 remained constant across age groups due to absence of screening. Copyright © 2012 UICC.

  12. Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease

    DEFF Research Database (Denmark)

    Sorensen, M.; Lassen, Ulrik Niels; Jensen, Peter Buhl

    2008-01-01

    and cisplatin are needed. The aim of this phase II study was to establish the response rate and response duration in chemo-naive patients with SCLC receiving a 3-day topotecan and cisplatin schedule. METHODS: Simons optimal two-stage design was used. Patients with previously untreated extensive disease SCLC......INTRODUCTION: Treatment with a topoisomerase I inhibitor in combination with a platinum results in superior or equal survival compared with etoposide-based treatment in extensive disease small cell lung cancer (SCLC). Five-day topotecan is inconvenient and therefore shorter schedules of topotecan......, adequate organ functions and performance status less than 3 were eligible. Topotecan (2.0 mg/m, intravenously) was administered on days 1 to 3 with cisplatin (50 mg/m, intravenously) on day 3 every 3 weeks for a total of six cycles. RESULTS: Forty-three patients received 219 cycles of chemotherapy. Median...

  13. EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

    Science.gov (United States)

    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen

    2015-12-01

    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity.

  14. Women's decision-making processes and the influences on their mode of birth following a previous caesarean section in Taiwan: a qualitative study.

    Science.gov (United States)

    Chen, Shu-Wen; Hutchinson, Alison M; Nagle, Cate; Bucknall, Tracey K

    2018-01-17

    Vaginal birth after caesarean (VBAC) is an alternative option for women who have had a previous caesarean section (CS); however, uptake is limited because of concern about the risks of uterine rupture. The aim of this study was to explore women's decision-making processes and the influences on their mode of birth following a previous CS. A qualitative approach was used. The research comprised three stages. Stage I consisted of naturalistic observation at 33-34 weeks' gestation. Stage II involved interviews with pregnant women at 35-37 weeks' gestation. Stage III consisted of interviews with the same women who were interviewed postnatally, 1 month after birth. The research was conducted in a private medical centre in northern Taiwan. Using a purposive sampling, 21 women and 9 obstetricians were recruited. Data collection involved in-depth interviews, observation and field notes. Constant comparative analysis was employed for data analysis. Ensuring the safety of mother and baby was the focus of women's decisions. Women's decisions-making influences included previous birth experience, concern about the risks of vaginal birth, evaluation of mode of birth, current pregnancy situation, information resources and health insurance. In communicating with obstetricians, some women complied with obstetricians' recommendations for repeat caesarean section (RCS) without being informed of alternatives. Others used four step decision-making processes that included searching for information, listening to obstetricians' professional judgement, evaluating alternatives, and making a decision regarding mode of birth. After birth, women reflected on their decisions in three aspects: reflection on birth choices; reflection on factors influencing decisions; and reflection on outcomes of decisions. The health and wellbeing of mother and baby were the major concerns for women. In response to the decision-making influences, women's interactions with obstetricians regarding birth choices

  15. Effect of treatment of a previous ectopic pregnancy on in vitro fertilization-intracytoplasmic sperm injection outcomes: a retrospective cohort study.

    Science.gov (United States)

    Xu, Zhen; Yan, Lei; Liu, Wen; Xu, Xinxin; Li, Miao; Ding, Lingling; Ma, Jinlong; Chen, Zi-Jiang

    2015-12-01

    To evaluate the influence of previous ectopic pregnancies (EP) and different EP treatment methods on in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes. Retrospective cohort study. University-based reproductive medicine center. Women undergoing 51,268 fresh cycles of IVF-ICSI. In women who had had an EP before the IVF treatment and women who were diagnosed with fallopian disease without an EP (control group), division into three treatment subgroups: subgroup 1, conservative treatment; subgroup 2, salpingostomy; and subgroup 3 salpingectomy. Estimates of IVF-ICSI outcome and ovarian function based on number of antral follicles and rates of implantation, EP, clinical pregnancy, and delivery. For the experimental group and the control group, there were no statistically significant differences in the rates of implantation, clinical pregnancy, or delivery. However, the risk of recurrent EP was statistically significantly higher in the experimental group compared with the control group. There were no statistically significant differences in IVF-ICSI outcomes between the three treatment subgroups in terms of the basic antral follicle number or the dominant antral follicle numbers (>1.0 cm) after surgical treatment of EP. Our results suggest that women with a prior history of EP have a higher recurrence risk of EP after IVF in comparison with women with no history of EP. Previous EP has no effect on the main IVF-ICSI outcomes. For the treatment of EP, salpingostomy and salpingectomy do not statistically significantly affect ovarian function. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  16. Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines.

    Science.gov (United States)

    Machover, D; Diaz-Rubio, E; de Gramont, A; Schilf, A; Gastiaburu, J J; Brienza, S; Itzhaki, M; Metzger, G; N'Daw, D; Vignoud, J; Abad, A; Francois, E; Gamelin, E; Marty, M; Sastre, J; Seitz, J F; Ychou, M

    1996-01-01

    Oxaliplatin (L-OHP) is a platinum complex that possesses activity against human and murine cells in vitro and in vivo, including colorectal carcinoma-derived cell lines, and cells that have been selected for resistance to cisplatin. We report two consecutive phase II trials of L-OHP for treatment of patients with advanced colorectal carcinoma. Fifty-eight patients were entered in study I, and 51 patients in study II. All of the patients had tumor progression when they were treated, prior to their enrollment, with a fluoropyrimidine-containing regimen. In both trials treatment consisted of L-OHP, 130 mg/m2, by i.v. infusion for two hours; the treatment was repeated every 21 days. Response to therapy: Study I: Fifty-five patients were assessed for response. The response rate was 11% (95% CI, 0.03-0.19). Study II: All 51 patients were assessed for response. The response rate was 10% (95% CI, 0.017-0.18). The overall response rate for the 106 evaluated patients was 10% (95% CI, 0.046-0.16). Times to disease progression in responders were 4, 4, 4.5+, 5, 5, 6, 6, 6, 6+, 9, and 13 months. The dose-limiting toxic effect was sensory peripheral neuropathy. The incidence of severe peripheral neuropathy grades was: Study I: grade 3, 23% of patients, and grade 4, 8% of patients. Severe neuropathy had a favorable course in all of the patients who had long-term neurologic follow-up. Diarrhea and myeloid impairment were minor. L-OHP produced modest, but definite antitumor activity in patients with advanced colorectal carcinoma who were previously resistant to chemotherapy including fluoropyrimidines. Toxicity is within acceptable limits of tolerance at the dose and schedule of oxaliplatin used in this trial.

  17. GeoSEA: Geodetic Earthquake Observatory on the Seafloor

    Science.gov (United States)

    Kopp, Heidrun; Lange, Dietrich; Flueh, Ernst R.; Petersen, Florian; Behrmann, Jan-Hinrich; Devey, Colin

    2014-05-01

    Space geodetic observations of crustal deformation have contributed greatly to our understanding of plate tectonic processes in general, and plate subduction in particular. Measurements of interseismic strain have documented the active accumulation of strain, and subsequent strain release during earthquakes. However, techniques such as GPS cannot be applied below the water surface because the electromagnetic energy is strongly attenuated in the water column. Evidence suggests that much of the elastic strain build up and release (and particularly that responsible for both tsunami generation and giant earthquakes) occurs offshore. To quantify strain accumulation and assess the resultant hazard potential we urgently need systems to resolve seafloor crustal deformation. Here we report on first results of sea trials of a newly implemented seafloor geodesy array. The GeoSEA (Geodetic Earthquake Observatory on the Seafloor) array consists of a seafloor transponder network comprising 35 units and a wave glider acting as a surface unit (GeoSURF) to ensure satellite correspondence, data transfer and monitor system health. Seafloor displacement occurs in the horizontal (x,y) and vertical direction (z). The vertical displacement is measured by monitoring pressure variations at the seafloor. Horizontal seafloor displacement can be measured either using an acoustic/GPS combination to provide absolute positioning (requiring a suitably equipped vessel to perform repeated cruises to provide the GPS fixes) or by long-term acoustic telemetry between different beacons fixed on the seafloor to determine relative distances by using the travel time observations to each other, which is the technique tested during our short sea trials. For horizontal direct path measurements, the system utilizes acoustic ranging techniques with a ranging precision better than 15 mm and long term stability over 2 km distances. Vertical motion is obtained from pressure gauges. Integrated inclinometers

  18. The priming effect of previous natural pandemic H1N1 infection on the immunogenicity to subsequent 2010-2011 influenza vaccination in children: a prospective cohort study.

    Science.gov (United States)

    Kang, Eun Kyeong; Eun, Byung Wook; Kim, Nam Hee; Lim, Jung Sub; Lee, Jun Ah; Kim, Dong Ho

    2016-08-22

    The effect of previous natural pandemic H1N1 (H1N1 pdm09) influenza infection on the immunogenicity to subsequent inactivated influenza vaccination in children has not been well studied. We aimed to evaluate the effect of H1N1 pdm09 natural infection and vaccination on the immunogenicity to subsequent 2010-2011 seasonal inactivated influenza vaccination in children. From October 2010 to May 2011, we conducted an open-label, multi-center study in children aged 6 months -18 years in Korea. We measured antibody titers with a hemagglutination-inhibition (HI) assay at baseline, 1 month, and 6 months after vaccination with trivalent split or subunit vaccines containing H1N1 pdm, A/H3N2, and B. The subjects were classified into 4 groups depending on the presence of laboratory-confirmed H1N1 pdm09 infection and/or vaccination in the 2009-2010 season; Group I: vaccination (-)/infection(-), Group II: vaccination (-)/infection(+), Group III: vaccination (+)/infection(-), Group IV: vaccination (+)/infection(+). Among the subjects in group I, 47 subjects who had a baseline titer >1:10 were considered to have an asymptomatic infection. They were included into the final group II (n = 80). We defined the new group II as the infection-primed (IP) group and group III as the vaccine-primed (VP) group. Seroconversion rate (57.5 % vs 35.9 %, p = 0.001), seroprotection rate at 6 months after vaccination (70.8 % vs 61.8 %, p = 0.032), and GMT at 1 month after vaccination (129.9 vs 66.5, p = 0.002) were significantly higher in the IP group than in the VP group. In the 9-18 year-old group, seroconversion rate and immunogenicity at 1 and 6 months were significantly higher in the IP group than in the VP group. However in the 1-7 year-old age group, there was no significant difference between the two groups. Previous H1N1 pdm09 infection appears to have positive effects on immunogenicity of subsequent inactivated influenza vaccines against H1N1 pdm09 in older

  19. Estimation of rod scale errors in geodetic leveling

    Science.gov (United States)

    Craymer, Michael R.; Vaníček, Petr; Castle, Robert O.

    1995-01-01

    Comparisons among repeated geodetic levelings have often been used for detecting and estimating residual rod scale errors in leveled heights. Individual rod-pair scale errors are estimated by a two-step procedure using a model based on either differences in heights, differences in section height differences, or differences in section tilts. It is shown that the estimated rod-pair scale errors derived from each model are identical only when the data are correctly weighted, and the mathematical correlations are accounted for in the model based on heights. Analyses based on simple regressions of changes in height versus height can easily lead to incorrect conclusions. We also show that the statistically estimated scale errors are not a simple function of height, height difference, or tilt. The models are valid only when terrain slope is constant over adjacent pairs of setups (i.e., smoothly varying terrain). In order to discriminate between rod scale errors and vertical displacements due to crustal motion, the individual rod-pairs should be used in more than one leveling, preferably in areas of contrasting tectonic activity. From an analysis of 37 separately calibrated rod-pairs used in 55 levelings in southern California, we found eight statistically significant coefficients that could be reasonably attributed to rod scale errors, only one of which was larger than the expected random error in the applied calibration-based scale correction. However, significant differences with other independent checks indicate that caution should be exercised before accepting these results as evidence of scale error. Further refinements of the technique are clearly needed if the results are to be routinely applied in practice.

  20. A MATLAB GEODETIC SOFTWARE FOR PROCESSING AIRBORNE LIDAR BATHYMETRY DATA

    Directory of Open Access Journals (Sweden)

    M. Pepe

    2015-04-01

    Full Text Available The ability to build three-dimensional models through technologies based on satellite navigation systems GNSS and the continuous development of new sensors, as Airborne Laser Scanning Hydrography (ALH, data acquisition methods and 3D multi-resolution representations, have contributed significantly to the digital 3D documentation, mapping, preservation and representation of landscapes and heritage as well as to the growth of research in this fields. However, GNSS systems led to the use of the ellipsoidal height; to transform this height in orthometric is necessary to know a geoid undulation model. The latest and most accurate global geoid undulation model, available worldwide, is EGM2008 which has been publicly released by the U.S. National Geospatial-Intelligence Agency (NGA EGM Development Team. Therefore, given the availability and accuracy of this geoid model, we can use it in geomatics applications that require the conversion of heights. Using this model, to correct the elevation of a point does not coincide with any node must interpolate elevation information of adjacent nodes. The purpose of this paper is produce a Matlab® geodetic software for processing airborne LIDAR bathymetry data. In particular we want to focus on the point clouds in ASPRS LAS format and convert the ellipsoidal height in orthometric. The algorithm, valid on the whole globe and operative for all UTM zones, allows the conversion of ellipsoidal heights using the EGM2008 model. Of this model we analyse the slopes which occur, in some critical areas, between the nodes of the undulations grid; we will focus our attention on the marine areas verifying the impact that the slopes have in the calculation of the orthometric height and, consequently, in the accuracy of the in the 3-D point clouds. This experiment will be carried out by analysing a LAS APRS file containing topographic and bathymetric data collected with LIDAR systems along the coasts of Oregon and Washington

  1. A prospective flexible-dose study of paliperidone palmitate in nonacute but symptomatic patients with schizophrenia previously unsuccessfully treated with oral antipsychotic agents.

    Science.gov (United States)

    Schreiner, Andreas; Bergmans, Paul; Cherubin, Pierre; Keim, Sofia; Rancans, Elmars; Bez, Yasin; Parellada, Eduard; Carpiniello, Bernardo; Vidailhet, Pierre; Hargarter, Ludger

    2014-10-01

    The goal of this study was to explore the tolerability, safety, and treatment response of flexible doses of once-monthly paliperidone palmitate (PP) in the subset of nonacute but symptomatic adult patients with schizophrenia previously unsuccessfully treated with oral antipsychotic agents in the PALMFlexS (Paliperidone Palmitate Flexible Dosing in Schizophrenia) study. This was an interventional, single-arm, international, multicenter, unblinded, 6-month study performed in patients with schizophrenia. Patients were categorized according to reasons for switching. In patients switching because of lack of efficacy or for other reasons, primary efficacy outcomes were the proportion achieving treatment response (defined as ≥20% improvement in Positive and Negative Syndrome Scale [PANSS] total score from baseline to last-observation-carried-forward end point) and maintained efficacy (defined as noninferiority in the change in PANSS total score at end point versus baseline [Schuirmann's test]), respectively. A total of 593 patients (intention-to-treat population) were enrolled: 63.1% were male; their mean (SD) age was 38.4 (11.8) years; and 78.6% had paranoid schizophrenia. The main reasons for transition to PP were patient's wish (n = 259 [43.7%]), lack of efficacy (n = 144 [24.3%]), lack of compliance (n = 138 [23.3%]), and lack of tolerability (n = 52 [8.8%]) with the previous oral antipsychotic medication. The recommended PP initiation regimen (150 milligram equivalents [mg eq] day 1 and 100 mg eq day 8) was administered in 93.9% of patients. Mean PANSS total score decreased from 71.5 (14.6) at baseline to 59.7 (18.1) at end point (mean change, -11.7 [15.9]; 95% CI, -13.0 to -10.5; P < 0.0001). Sixty-four percent of patients showed an improvement of ≥20% in PANSS total score, and the percentage of patients rated mildly ill or less in Clinical Global Impression-Severity increased from 31.8% to 63.2%. Mean personal and social performance total score (SD) increased

  2. Safety and tolerability of frovatriptan in the acute treatment of migraine and prevention of menstrual migraine: Results of a new analysis of data from five previously published studies.

    Science.gov (United States)

    MacGregor, E Anne; Pawsey, Stephen P; Campbell, John C; Hu, Xiaojun

    2010-04-01

    Triptans are a recommended first-line treatment for moderate to severe migraine. Using clinical trial data, we evaluated the safety and tolerability of frovatriptan as acute treatment (AT) and as short-term preventive (STP) therapy for menstrual migraine (MM). Data from 2 Phase III AT trials (AT1: randomized, placebo controlled, 1 attack; AT2: 12-months, noncomparative, open label) and 3 Phase IIIb STP trials in MM (MMP1 and MMP2: randomized, placebo controlled, double blind, 3 perimenstrual periods; MMP3: open label, noncomparative, 12 perimenstrual periods) were analyzed. In AT1, patients treated each attack with frovatriptan 2.5 mg, sumatriptan 100 mg, or placebo. In AT2, they used frovatriptan 2.5 mg. In MMP1 and MMP2, women administered frovatriptan 2.5 mg for 6 days during the perimenstrual period, taking a loading dose of 2 or 4 tablets on day 1, followed by once-daily or BID frovatriptan 2.5 mg, respectively; in MMP3, they used BID frovatriptan 2.5 mg. In AT1, which was previously published in part, group differences in adverse events (AEs) were analyzed using the Fisher exact test, and response rates were compared using logistic regression. Post hoc analyses of sustained pain-free status with no AEs (SNAE) and sustained pain response with no AEs (SPRNAE) were performed using a 2-sample test for equality of proportions without continuity correction. For AT2 and the STP studies, data were summarized using descriptive statistics. Results of individual safety analyses for the STP studies were previously reported; the present report includes new results from a pooled analysis of MMP1 and MMP2 and a new analysis of MMP3 in which AEs were coded using Medical Dictionary for Regulatory Activities version 8.0. AT1 included 1206 patients in the safety group; AT2 included 496. In the STP studies, safety data were collected for 1487 women. In AT1 and AT2, 85.6% and 88.3%, respectively, of enrolled patients were women. Overall, AEs were generally mild to moderate (AT

  3. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    International Nuclear Information System (INIS)

    Rivero, Javier; Luzardo, Octavio P.; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-01-01

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  4. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Javier; Luzardo, Octavio P., E-mail: octavio.perez@ulpgc.es; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-12-15

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  5. Feasibility of Construction of the Continuously Operating Geodetic GPS Network of Sinaloa, Mexico

    Science.gov (United States)

    Vazquez, G. E.; Jacobo, C.

    2011-12-01

    This research is based on the study and analysis of feasibility for the construction of the geodetic network for GPS continuous operation for Sinaloa, hereafter called (RGOCSIN). A GPS network of continuous operation is defined as that materialized structure physically through permanent monuments where measurements to the systems of Global Positioning (GPS) is performed continuously throughout a region. The GPS measurements in this network are measurements of accuracy according to international standards to define its coordinates, thus constituting the basic structure of geodetic referencing for a country. In this context is that in the near future the RGOCSIN constitutes a system state only accurate and reliable georeferencing in real-time (continuous and permanent operation) and will be used for different purposes; i.e., in addition to being fundamental basis for any lifting topographic or geodetic survey, and other areas such as: (1) Different construction processes (control and monitoring of engineering works); (2) Studies of deformation of the Earth's crust (before and after a seismic event); (3) GPS meteorology (weather forecasting); (4) Demarcation projects (natural and political); (5) Establishment of bases to generate mapping (necessary for the economic and social development of the state); (6) Precision agriculture (optimization of economic resources to the various crops); (7) Geographic information systems (Organization and planning activities associated with the design and construction of public services); (8) Urban growth (possible settlements in the appropriate form and taking care of the environmental aspect), among others. However there are criteria and regulations according to the INEGI (Instituto Nacional de Estadística y Geografía, http://www.inegi.org.mx/) that must be met; even for this stage of feasibility of construction that sees this project as a first phase. The fundamental criterion to be taken into account according to INEGI is a

  6. Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru.

    Science.gov (United States)

    Lanata, Claudio F; Andrade, Teresa; Gil, Ana I; Terrones, Cynthia; Valladolid, Omar; Zambrano, Betzana; Saville, Melanie; Crevat, Denis

    2012-09-07

    In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a recombinant, live, attenuated, tetravalent dengue vaccine candidate (CYD-TDV) in 2-11 year-olds with varying levels of pre-existing yellow-fever immunity due to vaccination 1-7 years previously. 199 children received 3 injections of CYD-TDV (months 0, 6 and 12) and 99 received placebo (months 0 and 6) or pneumococcal polysaccharide vaccine (month 12). One month after the third dengue vaccination, serotype specific neutralizing antibody GMTs were in the range of 178-190 (1/dil) (versus 16.7-38.1 in the control group), a 10-20 fold-increase from baseline, and 94% of vaccines were seropositive to all four serotypes (versus 39% in the control group). There were no vaccine-related SAEs. The observed reactogenicity profile was consistent with phase I studies, with severity grade 1-2 injection site pain, headache, malaise and fever most frequently reported and no increase after subsequent vaccinations. Virologically confirmed dengue cases were seen after completion of the 3 doses: 1 in the CYD-TDV group (N=199), and 3 in the control group (N=99). A 3-dose regimen of CYD-TDV had a good safety profile in 2-11 year olds with a history of YF vaccination and elicited robust antibody responses that were balanced against the four serotypes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. A real life study of Helicobacter pylori eradication with bismuth quadruple therapy in naïve and previously treated patients

    Directory of Open Access Journals (Sweden)

    Blas José Gómez-Rodríguez

    Full Text Available Objective: To evaluate the efficacy and safety of a quadruple regimen (BMTO of the "3-in-1 capsule" (containing bismuth subcitrate potassium, metronidazole and tetracycline plus omeprazole in naïve and previously treated patients diagnosed with Helicobacter pylori (H. pylori infection in the clinical setting in Seville (Spain. Methods: This is a prospective study carried out on consecutive patients with a confirmed H. pylori infection and upper gastrointestinal symptoms. After providing their informed consent, the patients were treated for ten days with a 3-in-1 capsule containing bismuth subcitrate potassium (140 mg, metronidazole (125 mg and tetracycline (125 mg: Pylera®, three capsules four times daily, plus omeprazole (20 or 40 mg twice daily. Eradication of infection was determined by a negative urea breath test at least 28 days after the end of treatment. Results: A total of 58 consecutive patients were enrolled into this study, two of whom withdrew early due to vomiting on days three and five, respectively. In this cohort, 17 patients (29.3% had a prior history of medication to treat H. pylori. In the intent-to-treat population, eradication was achieved in 97.6% (40/41 and 82.4% (14/17 of cases in patients treated with BMTO as a first-line or rescue therapy, respectively. At least one adverse event was reported by 28 (48% patients, mostly mild effects (86%. Conclusion: A ten day treatment with BMTO is an effective and safe strategy to combat confirmed H. pylori infection in patients.

  8. A phase II study of VP-16-ifosfamide-cisplatin combination chemotherapy plus early concurrent thoracic irradiation for previously untreated limited small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Woo, In Sook; Park, Young Suk; Kwon, Sung Hee [Hallym Univ., Seoul (Korea, Republic of). Coll. of Medicine] [and others

    2000-12-01

    At present the addition of thoracic irradiation to combination chemotherapy is a standard treatment for limited staged small cell ling cancer. However, there is still controversy about the optimum timing of chest irradiation. We conducted a phase II study of etoposide (VP-16)-ifosfamide-cisplatin (VIP) combination chemotherapy plus early concurrent thoracic irradiation for the patients with previously untreated limited small cell lung cancer in order to assess if the treatment modality could improve the response rate and the toxicity. Forty-four patients with limited small cell lung cancer were treated with etoposide-ifosfamide-cisplatin and concurrent thoracic irradiation. Combination chemotherapy consisted of etoposide 100 mg/m{sup 2} (on day 1-3), ifosfamide 1000 mg/m{sup 2} (on days 1 and 2) and cisplatin 100 mg/m{sup 2} (on day 1). Concurrent thoracic irradiation consisted of a total of 4000 cGy over 4 weeks starting on the first day of the first chemotherapy. All patients who showed a complete response were given prophylactic cranial irradiation for 2.5 weeks. Forty-four of the 49 patients who entered the study from May 1994 to August 1998 were evaluable. The median age was 59 years and 40 patients had a performance status of 0 or 1. The median survival time was 22.5 months. Twenty-eight patients (62%) showed a complete response and 16 (38%) a partial response. Twenty-four patients (54%) developed grade 3 or 4 neutropenia; there was a 9% RTOG score 3 or 4 esophagitis. VIP combination chemotherapy and early concurrent thoracic irradiation for patients with limited stage small cell lung cancer revealed excellent antitumor response with tolerable toxicity. (author)

  9. An Investigation on the Use of Different Centroiding Algorithms and Star Catalogs in Astro-Geodetic Observations

    Science.gov (United States)

    Basoglu, Burak; Halicioglu, Kerem; Albayrak, Muge; Ulug, Rasit; Tevfik Ozludemir, M.; Deniz, Rasim

    2017-04-01

    In the last decade, the importance of high-precise geoid determination at local or national level has been pointed out by Turkish National Geodesy Commission. The Commission has also put objective of modernization of national height system of Turkey to the agenda. Meanwhile several projects have been realized in recent years. In Istanbul city, a GNSS/Levelling geoid was defined in 2005 for the metropolitan area of the city with an accuracy of ±3.5cm. In order to achieve a better accuracy in this area, "Local Geoid Determination with Integration of GNSS/Levelling and Astro-Geodetic Data" project has been conducted in Istanbul Technical University and Bogazici University KOERI since January 2016. The project is funded by The Scientific and Technological Research Council of Turkey. With the scope of the project, modernization studies of Digital Zenith Camera System are being carried on in terms of hardware components and software development. Accentuated subjects are the star catalogues, and centroiding algorithm used to identify the stars on the zenithal star field. During the test observations of Digital Zenith Camera System performed between 2013-2016, final results were calculated using the PSF method for star centroiding, and the second USNO CCD Astrograph Catalogue (UCAC2) for the reference star positions. This study aims to investigate the position accuracy of the star images by comparing different centroiding algorithms and available star catalogs used in astro-geodetic observations conducted with the digital zenith camera system.

  10. Displacement response of a concrete arch dam to seasonal temperature fluctuations and reservoir level rise during the first filling period: evidence from geodetic data

    OpenAIRE

    Cemal Ozer Yigit; Salih Alcay; Ayhan Ceylan

    2016-01-01

    The present study evaluates the dynamic behaviour of the Ermenek Dam, the second highest dam in Turkey, based on conventional geodetic measurements and Finite Element Model (FEM) analyses during its first filling period. In total, eight periods of measured deformation are considered from the end of construction until the reservoir reached its full capacity. The displacement response of the dam to the reservoir level and to seasonal temperature variations is examined in detail. Time series of ...

  11. Determination Of Horizontal Geodetic Control Networks For Engineering Objects Using Optoelectronic Techniques

    Directory of Open Access Journals (Sweden)

    Ćmielewski Kazimierz

    2015-07-01

    Full Text Available The correctness of the geodetic service of an engineering object not seldom requires designing, alignment or renewing of geodetic situational control points. Building robots often cause that fixed situational control points are partly or completely inaccessible. For setting the position of these control points, there is worked out the methodology using the optoelectronic method. The prepared set of tools realizes the method’s assumptions and enables to determine the sides and control points based on the set of laser planes. In this article there is presented the innovative set of geodetic equipment for fixing horizontal control points. The presented set has been experimentally tested under laboratory conditions taking its functionality, operation range and applied accuracy into account. The measurement accuracy of the set of tools, resulting from identification of the energetic centres of laser planes’ edges, visualizing the sides of geodetic control networks, is within the range of ±0.02mm - ±0.05mm. There were also discussed exemplary versions of shapes and structures of horizontal geodetic control networks (regular and irregular, which are possible to be fixed with the use of the constructed set of tools.

  12. Phase I/II study of gefitinib (Iressa(®)) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer.

    Science.gov (United States)

    Han, Ji-Youn; Lee, Soo Hyun; Lee, Geon Kook; Yun, Tak; Lee, Young Joo; Hwang, Kum Hui; Kim, Jin Young; Kim, Heung Tae

    2015-03-01

    Vorinostat has been shown to overcome resistance to gefitinib. We performed a phase I/II study combining gefitinib with vorinostat in previously treated non-small cell lung cancer (NSCLC). A 3 + 3 dose-escalation design was used to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Three dose levels were tested: 250 mg/day gefitinib on days 1-28 and 200, 300 or 400 mg/day vorinostat on days 1-7, and 15-21 out of every 28 days. The primary endpoint was median progression-free survival (PFS). Fifty-two patients were enrolled and treated (43 in phase II). The median age was 59 years, 28 patients were male, 44 had adenocarcinoma, 29 had never smoked, and 36 had undergone one prior treatment. Twenty-two patients exhibited sensitive EGFR mutations. Planned dose escalation was completed without reaching the MTD. The RP2D was 250 mg gefitinib and 400 mg vorinostat. In 43 assessable patients in phase II, the median PFS was 3.2 months; the overall survival (OS) was 19.0 months. There were 16 partial responses and six cases of stable disease. In EGFR-mutant NSCLC, response rate was 77 %, median PFS was 9.1 months, and median OS was 24.1 months. The most common adverse events were anorexia and diarrhea. Treatment with 250 mg gefitinib daily with biweekly 400 mg/day vorinostat was feasible and well tolerated. In an unselected patient population, this combination dose did not improve PFS. However, this combination showed a potential for improving efficacy of gefitinib in EGFR-mutant NSCLC (NCT01027676).

  13. Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.

    Science.gov (United States)

    Klinger, Tatjana; Ibach, Bernd; Schoenknecht, Peter; Kamleiter, Martin; Silver, Gabrielle; Schroeder, Johannes; Mielke, Ruediger

    2005-05-01

    This open-label, prospective, observational, Post-Marketing Surveillance (PMS) study assessed the efficacy and safety of donepezil in patients who had been switched from therapies currently used in Germany to treat Alzheimer's disease (AD), such as memantine and nootropics, due to insufficient efficacy or poor tolerability. A treatment-naive population was included as a comparator. Patients with AD were treated with donepezil and observed for a period of approximately 3 months. A cognitive assessment was made using the Mini-Mental State Examination (MMSE). Quality of life (QoL) was assessed by the investigators who answered the question 'How did therapy with donepezil influence the QoL of the patient and/or his family over the observation period?' and was graded using three ratings: improved/unchanged/worsened. Adverse events (AEs) were also monitored. A total of 913 patients entered the study (mean +/- SD MMSE score 18.03 +/- 5.34). Efficacy assessments were analyzed for three groups: an overall group of patients who had received any form of prior AD drug therapy (N+ group; n = 709); a subgroup of patients from the N+ group who had received prior memantine therapy only (M+ group; n = 111) and patients who were drug treatment naive (N- group; n = 204). In the evaluable population donepezil improved MMSE scores by 2.21 +/- 3.47 points on average, with similar improvements observed in all three groups. QoL was judged to be improved in at least 70% of patients, again with similar results obtained for all three groups. Donepezil was well tolerated, with 85 of 913 (9.3%) patients reporting AEs. The most common AEs were those typically seen with cholinergic therapies (i.e., diarrhoea, vomiting and nausea). In this observational PMS study, donepezil was shown to be efficacious and well tolerated in patients who were being insufficiently treated with memantine or nootropic therapy. The magnitude of response was similar to that observed in patients who were previously

  14. Displacement response of a concrete arch dam to seasonal temperature fluctuations and reservoir level rise during the first filling period: evidence from geodetic data

    Directory of Open Access Journals (Sweden)

    Cemal Ozer Yigit

    2016-07-01

    Full Text Available The present study evaluates the dynamic behaviour of the Ermenek Dam, the second highest dam in Turkey, based on conventional geodetic measurements and Finite Element Model (FEM analyses during its first filling period. In total, eight periods of measured deformation are considered from the end of construction until the reservoir reached its full capacity. The displacement response of the dam to the reservoir level and to seasonal temperature variations is examined in detail. Time series of apparent total displacements at the middle of the crest of the dam exhibits periodicity and linear trends. Correlation analysis revealed that periodic and linear displacement responses of the dam are related to variations of seasonal temperature and linearly increased reservoir level, respectively, indicating a relation between temperature, water load and dam deformation. It is also concluded that measured deformations based on geodetic data show good agreement with the predicted deformation obtained by the FEM analysis.

  15. Geodetic infrastructure at the Barcelona harbour for sea level monitoring

    Science.gov (United States)

    Martinez-Benjamin, Juan Jose; Gili, Josep; Lopez, Rogelio; Tapia, Ana; Pros, Francesc; Palau, Vicenc; Perez, Begona

    2015-04-01

    The presentation is directed to the description of the actual geodetic infrastructure of Barcelona harbour with three tide gauges of different technologies for sea level determination and contribution to regional sea level rise and understanding past and present sea level rise in the Barcelona harbour. It is intended that the overall system will constitute a CGPS Station of the ESEAS (European Sea Level) and TIGA (GPS Tide Gauge Benchmark Monitoring) networks. At Barcelona harbour there is a MIROS radar tide gauge belonging to Puertos del Estado (Spanish Harbours).The radar sensor is over the water surface, on a L-shaped structure which elevates it a few meters above the quay shelf. 1-min data are transmitted to the ENAGAS Control Center by cable and then sent each 1 min to Puertos del Estado by e-mail. The information includes wave forescast (mean period, significant wave height, sea level, etc.This sensor also measures agitation and sends wave parameters each 20 min. There is a GPS station Leica Geosystems GRX1200 GG Pro and antenna AX 1202 GG. The Control Tower of the Port of Barcelona is situated in the North dike of the so-called Energy Pier in the Barcelona harbor (Spain). This tower has different kind of antennas for navigation monitoring and a GNSS permanent station. As the tower is founded in reclaimed land, and because its metallic structure, the 50 m building is subjected to diverse movements, including periodic fluctuations due to temperature changes. In this contribution the 2009, 2011, 2012, 2013 and 2014 the necessary monitoring campaigns are described. In the framework of a Spanish Space Project, the instrumentation of sea level measurements has been improved by providing the Barcelona site with a radar tide gauge Datamar 2000C from Geonica S.L. in June 2014 near an acoustic tide gauge from the Barcelona Harbour installed in 2013. Precision levelling has been made several times in the last two years because the tower is founded in reclaimed land and

  16. Geodetic measurements near Parkfield, California, 1959-1984

    Science.gov (United States)

    King, N. E.; Segall, P.; Prescott, W.

    1987-03-01

    Trilateration measurements have been made by various agencies since 1959 near Parkfield, California, in the transition zone between the central creeping section and the southern locked section of the San Andreas fault. Within the transition zone there are several creep meters and alignment arrays, four small-aperture trilateration networks, and a broad trilateration network extending 70 km southwest from the San Andreas fault to the Pacific coast. Line length changes observed after the 1966 ML = 5.6 Parkfield earthquake indicate a geodetic moment of 4.5 ± 1.0 × 1025 dyn cm. The data are consistent with either 91 ± 8 cm slip on a rupture zone which is 30 km long and extends from 3 to 8 km below the surface or 59 ± 5 cm on a 30-km-long zone 2-10 km deep. This moment estimate includes some postseismic slip and is a factor of 2-4 greater than the moment determined from seismic surface waves. The post-1966 data set is well suited to discriminate between the effects of surface and deep slip. Surface slip rates determined by creep meters, alinement arrays, and small-aperture trilateration networks decrease from 29 mm/yr at Slack Canyon to zero south of Highway 46; a gradient of roughly -0.48 ± 0.01 mm/yr/km. Deformation of a subset of the trilateration network between Cholame and San Luis Obispo is consistent with shallow slip of 2.9 ± 1.2 mm/yr from the surface to a depth of 16 km and 33.4 ± 5.5 mm/yr below 16 km. The trilateration data alone do not uniquely constrain both the transition depth from shallow to deep slip and the deep slip rate. A transition depth near 16 km is preferred because it provides the best fit to the data and because the predicted slip rate is consistent with independent estimates of the total slip rate across the San Andreas fault. This simple two-dimensional model neglects along-strike variations in the deformation. The data show no evidence for significant strike-slip deformation across faults between the San Andreas and the Pacific

  17. The Earth isn't flat: The (large) influence of topography on geodetic fault slip imaging.

    Science.gov (United States)

    Thompson, T. B.; Meade, B. J.

    2017-12-01

    While earthquakes both occur near and generate steep topography, most geodetic slip inversions assume that the Earth's surface is flat. We have developed a new boundary element tool, Tectosaur, with the capability to study fault and earthquake problems including complex fault system geometries, topography, material property contrasts, and millions of elements. Using Tectosaur, we study the model error induced by neglecting topography in both idealized synthetic fault models and for the cases of the MW=7.3 Landers and MW=8.0 Wenchuan earthquakes. Near the steepest topography, we find the use of flat Earth dislocation models may induce errors of more than 100% in the inferred slip magnitude and rake. In particular, neglecting topographic effects leads to an inferred shallow slip deficit. Thus, we propose that the shallow slip deficit observed in several earthquakes may be an artefact resulting from the systematic use of elastic dislocation models assuming a flat Earth. Finally, using this study as an example, we emphasize the dangerous potential for forward model errors to be amplified by an order of magnitude in inverse problems.

  18. Co-location of space geodetic techniques carried out at the Geodetic Observatory Wettzell using a closure in time and a multi-technique reference target

    Science.gov (United States)

    Kodet, J.; Schreiber, K. U.; Eckl, J.; Plötz, C.; Mähler, S.; Schüler, T.; Klügel, T.; Riepl, S.

    2018-01-01

    The quality of the links between the different space geodetic techniques (VLBI, SLR, GNSS and DORIS) is still one of the major limiting factors for the realization of a unique global terrestrial reference frame that is accurate enough to allow the monitoring of the Earth system, i.e., of processes like sea level change, postglacial rebound and silent earthquakes. According to the specifications of the global geodetic observing system of the International Association of Geodesy, such a reference frame should be accurate to 1 mm over decades, with rates of change stable at the level of 0.1 mm/year. The deficiencies arise from inaccurate or incomplete local ties at many fundamental sites as well as from systematic instrumental biases in the individual space geodetic techniques. Frequently repeated surveys, the continuous monitoring of antenna heights and the geometrical mount stability (Lösler et al. in J Geod 90:467-486, 2016. https://doi.org/10.1007/s00190-016-0887-8) have not provided evidence for insufficient antenna stability. Therefore, we have investigated variations in the respective system delays caused by electronic circuits, which is not adequately captured by the calibration process, either because of subtle differences in the circuitry between geodetic measurement and calibration, high temporal variability or because of lacking resolving bandwidth. The measured system delay variations in the electric chain of both VLBI- and SLR systems reach the order of 100 ps, which is equivalent to 3 cm of path length. Most of this variability is usually removed by the calibrations but by far not all. This paper focuses on the development of new technologies and procedures for co-located geodetic instrumentation in order to identify and remove systematic measurement biases within and between the individual measurement techniques. A closed-loop optical time and frequency distribution system and a common inter-technique reference target provide the possibility to remove

  19. Phase I study of cisplatin, hyperthermia, and lapatinib in patients with recurrent carcinoma of the uterine cervix in a previously irradiated area

    NARCIS (Netherlands)

    E.V. Meerten (Esther Van); M. Franckena (Martine); E.A.C. Wiemer (Erik); L.V. Doorn (Lena Van); J. Kraan (Jaco); A.M. Westermann (Anneke); S. Sleijfer (Stefan)

    2015-01-01

    textabstractBackground. Patients with recurrent cervical cancer in a previously irradiated area might benefit from cisplatin combined with hyperthermia. Lapatinib inhibits the intracellular tyrosine kinase domain of the epidermal growth factor receptor (EGFR) and HER2. Overexpression of EGFR and

  20. Phase I study of cisplatin, hyperthermia, and lapatinib in patients with recurrent carcinoma of the uterine cervix in a previously irradiated area

    NARCIS (Netherlands)

    van Meerten, Esther; Franckena, Martine; Wiemer, Erik; van Doorn, Lena; Kraan, Jaco; Westermann, Anneke; Sleijfer, Stefan

    2015-01-01

    Patients with recurrent cervical cancer in a previously irradiated area might benefit from cisplatin combined with hyperthermia. Lapatinib inhibits the intracellular tyrosine kinase domain of the epidermal growth factor receptor (EGFR) and HER2. Overexpression of EGFR and HER2 is frequently seen in

  1. Clinical evaluation of recombinant factor VIII preparation (Kogenate) in previously treated patients with hemophilia A: descriptive meta-analysis of post-marketing study data.

    Science.gov (United States)

    Yoshioka, A; Fukutake, K; Takamatsu, J; Shirahata, A

    2006-08-01

    The safety and efficacy of Kogenate, a recombinant factor VIII (rFVIII) preparation for the treatment of bleeding episodes, were studied in a 123-patient meta-analysis population of previously treated patients (PTPs), including 15 enrolled in the registration Phase III trial (PTP-I group), 93 from the post-marketing special investigation (PTP-II group), and 15 from short-term special investigations in surgery or tooth extraction (SI group). These patients (82 severe, 31 moderate, 9 mild, and 1 unknown), aged 11 months to 72 years, were enrolled in 28 centers in Japan. Blood samples taken at the baseline and at 3, 6, 9, 12, 18, and 24 months after the introduction of Kogenate were evaluated for FVIII inhibitor antibodies, antibodies formed against trace proteins derived from the rFVIII production process, and for general changes in laboratory test results. Mean exposure to Kogenate was 1103 days in PTP-I, 86 days in PTP-II, 27 days in patients in surgery, and 2 days in patients with tooth extraction. Assessment of FVIII inhibitor activity was conducted in 115 of the 123 patients by means of the Bethesda assay. Twelve patients were found to have a low titer of FVIII inhibitor (0.5-3.0 BU/mL) prior to any administration of Kogenate, and 103 were inhibitor-negative at the baseline. Among this latter group, 3 patients (2.9%) tested inhibitor-positive, with titers ranging from 1.2 to 2.1 BU/mL, with 4 patients below 1.0 BU/mL. One patient in the 11 PTPs investigated (PTP-I) developed antibodies against baby hamster kidney protein and mouse immunoglobulin G, but these findings were transient and asymptomatic. Hemostasis was achieved (markedly effective or effective) in 3666 of the 3855 bleeding episodes (95.1%) observed in 108 patients. Only 1 infusion was necessary in 3790 (98.3%) of these episodes. These data indicate that Kogenate is safe and very effective for the treatment of bleeding in PTPs with hemophilia A.

  2. Effects of epilepsy and selected antiepileptic drugs on risk of myocardial infarction, stroke, and death in patients with or without previous stroke: a nationwide cohort study

    DEFF Research Database (Denmark)

    Olesen, J. B.; Abildstrom, S. Z.; Erdal, Jesper

    2011-01-01

    Purpose Patients with epilepsy have increased morbidity and mortality. We evaluated the risk of myocardial infarction (MI), stroke, and death associated with epilepsy and examined if this risk was modified by treatment with antiepileptic drugs (AEDs). Methods A cohort consisting of the Danish...... population was followed from January 1997 to December 2006. The risk of MI, stroke, cardiovascular death, and all-cause death associated with epilepsy was estimated by multivariable Cox proportional hazard models stratified for occurrence of previous stroke. AED use was determined at baseline, and risks...... associated with exposure to individual AEDs were examined in patients with epilepsy. Results In patients without previous stroke, AED-treated epilepsy was associated with an increased risk of MI (hazard ratio [HR], 1.09; 95%CI, 1.00-1.19), stroke (HR, 2.22; 95%CI, 2.09-2.36), cardiovascular death (HR, 1...

  3. DORIS data analysis at Geodetic Observatory Pecný using single-satellite and multi-satellite geodetic solutions

    Science.gov (United States)

    Štěpánek, Petr; Douša, Jan; Filler, Vratislav; Hugentobler, Urs

    2010-12-01

    The DORIS (Doppler Orbitography and Radiopositioning Integrated by Satellite) data are processed in the framework of the International DORIS Service (IDS) at several analysis centers. Each analysis center follows its own processing strategy and models. This manuscript presents the results of the processing based on a development version 5.0 of the Bernese GPS Software at the Geodetic Observatory Pecný analysis center (GOP). The complete period 1993.0-2009.0 was processed applying the free-network approach in order to estimate main parameters namely station and polar motion coordinates. A significant improvement has been achieved in the estimated station coordinates and polar parameters by processing the data from the satellites equipped with the second generation of the DORIS receiver, SPOT-5 and Envisat, launched in 2002. The RMS of polar coordinates in 2003.0-2008.0 shows a decreasing trend over the entire analyzed time period. The transformation parameters between the DORIS solution and ITRF2005 were subjected to a spectral analysis, confirming the domination of the annual and semiannual periodicity. The behavior of the terrestrial reference frame scale is quite stable with a few exceptions. The analysis of a major scale shift at the end of 2004 revealed SPOT-5 and Envisat satellites as the source of the problem. However, the termination of the TOPEX/Poseidon DORIS data processing at the end of 2004 did not influence significantly the overall scale level. Another objective of the paper is a detailed analysis of relations between the value of the observation residuals and the length of the observation Doppler count interval. A simple empirical model considering the observation noise as a sum of the constant and time-dependent terms is propounded and discussed. The estimated troposphere total zenith delays are compared to the corresponding values derived from GNSS (IGS PPP products) and the source of the differences as well as their systematic behavior and

  4. A pilot study of the combination of cyclosporin A and interferon alfacon-1 for the treatment of hepatitis C in previous nonresponder patients.

    Science.gov (United States)

    Cotler, Scott J; Morrissey, Mary J; Wiley, Thelma E; Layden, Thomas J; Jensen, Donald M

    2003-04-01

    To evaluate the safety and efficacy of the combination of interferon and cyclosporine for the treatment of hepatitis C in previous nonresponder patients. Preliminary data indicated that adding the immunosuppressive agent cyclosporin A to interferon might improve response rates in patients with hepatitis C. Ten previous virologic nonresponders with genotype 1 infection were included. Treatment consisted of interferon alfacon-1, 15 microg/d, and cyclosporine, 100 mg twice daily, for 4 weeks. The dose of interferon alfacon-1 was then decreased to 15 microg three times weekly, and cyclosporine was reduced to 50 mg twice daily. Therapy was continued for 48 weeks unless viremia persisted at week 24. Three of 10 subjects had an on-treatment virologic response, although one had a breakthrough with recurrent viremia during treatment and two relapsed after therapy was completed. On treatment responders had significantly higher trough cyclosporine levels at week 4 compared with nonresponders (P = 0.025). Serum creatinine levels remained stable, and no patient developed diabetes. Triglyceride levels increased during treatment. Cyclosporine was dose reduced in two patients for hypertension. Selected patients with hepatitis C tolerated therapy, including cyclosporine without severe or irreversible toxicity. Despite an association between higher cyclosporine levels and on-treatment response, the combination of cyclosporine and interferon was ineffective in producing a sustained response in previous nonresponder patients.

  5. Uvođenje novih geodetskih referentnih sistema u Bosni i Hercegovini : Introduction of a new geodetic reference systems in Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Šeho Zimić

    2017-12-01

    Full Text Available The introduction of a new reference system in Bosnia and Herzegovina is not only a necessity, but an obligation imposed by the United Nations (UN and the European Union (EU. At the General Assembly on February 26, 2015, the UN has adopted a resolution titled "Global Geodetic Reference Frame for Sustainable Development - GGRF", which for the first time raise the geodetic issue as a political issue at such a high level. The resolution highlights the strong need for more precise positioning and navigation from the use of smartphones to the study of climate changes, population migrations and other scientific researches of relevance to the whole world (http://www.unggrf.org/. All this is not possible without a global exchange of geodata and a common global geodetic reference system. Through the Inspire Directive, the EU has clearly specified which coordinate and heights systems are being applied in Europe. The countries in the region have adopted the European terrestrial reference system ETRS89 as a new reference system in their legislation. Through the EUREF campaign BALKAN98 and the introduction of the Network of permanent GNSS stations Bosnia and Herzegovina has joined the famil

  6. Initial experiencies with the geodetic operations at the construction of the Paks nuclear power plant

    International Nuclear Information System (INIS)

    Karsay, F.; Specziar, A.

    1983-01-01

    The extensive geodetic contribution amounting to 1-2% of the total construction expenses of the Paks nuclear power plant required great effort from the geodetic companies involved. In 1982, as much as 60 persons were applied at the site of the construction, most of them educated professionals. In the course of the works, several technical developments were achieved. The preparatory period of the first stage involved basic map preparations, the next stage consisted of photogrammetric and management operations, the final period was dominated by inspections. Despite the strict requirements the work was accomplished without obstructing the construction and free from accidents. (Sz.J.)

  7. Space-geodetic estimation of the nazca-south america euler vector

    Science.gov (United States)

    Angermann, D.; Klotz, J.; Reigber, C.

    1999-09-01

    GPS data from four sites in the Nazca Plate (Easter Island, Galapagos, Robinson Crusoe and San Felix Islands) and from five sites in the stable core of the South American Plate enabled us to estimate the Euler vector of the Nazca Plate with respect to South America. The observed velocities of Easter Island (6.6 cm/yr at 102.3°), Galapagos (5.1 cm/yr at 90.0°), Robinson Crusoe (6.6 cm/yr at 80.1°) and San Felix (6.0 cm/yr at 82.1°) are significantly slower than the global plate model NUVEL-1A velocites for those four sites. Our estimated Euler pole is located at 48.8°N, 91.7°W with a rate of 0.59°/m.y. The NUVEL-1A and earlier space-geodetic studies give rotation rates that are 20% faster.

  8. 2011-2012 Campaign GPS Geodetic Monitoring of Surface Deformation, Dominica, Lesser Antilles

    Science.gov (United States)

    Miller, J. A.; Mattioli, G. S.; James, S. A.

    2012-12-01

    Over the last decade, ongoing campaign style geodetic surveys have been conducted on the volcanic island of Dominica in central portion of the Lesser Antilles island arc. An increase in shallow seismicity on the island, the first concentrated in the south from 1998-2000 and the second in the north in 2003, motivated initial measurements in 2001 at 9 sites distributed across Dominica. Subsequent GPS campaigns were conducted in 2003, 2004 and 2007, during which 18 new sites were added to the original network. In 2007, a total of 27 sites were occupied. The most recent data were collected from 13 sites in 2011 and 9 sites in 2012. Out of the 27 sites on the Island, 5 were not occupied during the 2011/2012 field seasons due to accessibility issues. All GPS data have been reprocessed using GIPSY-OASIS II (v. 6) with final, precise IGS08 orbits, clocks, and earth orientation parameters using an absolute point positioning strategy. The purpose of our study is to examine spatial and temporal changes in surface deformation, constrained by GPS, and to investigate the relationship between the recent seismic swarms and shallow volcanic processes.

  9. The crustal velocity field mosaic of the Alpine Mediterranean area (Italy): Insights from new geodetic data

    Science.gov (United States)

    Farolfi, Gregorio; Del Ventisette, Chiara

    2016-04-01

    A new horizontal crustal velocity field of Alpine Mediterranean area was determined by continuous long time series (6.5 years) of 113 Global Navigation Satellite System (GNSS) permanent stations. The processing was performed using state-of-the-art absolute antenna phase center correction model and recomputed precise IGS orbits available since April 2014. Moreover, a new more accurate tropospheric mapping function for geodetic applications was adopted. Results provide a new detailed map of the kinematics throughout the entire study area. This area is characterized by a complex tectonic setting driven by the interaction of Eurasian and African plates. The eastern Alps, Corsica, Sardinia and the Tyrrhenian Sea (which is covered only by interpolation data) show small velocity residuals with respect to the Eurasian plate. The whole Apennines axis discriminates two different velocity patterns, the Adriatic and the Tyrrhenian area. The area around Messina Strait, which separates peninsular Italy and Sicily, represents a poorly understood region. Results identify an important boundary zone between two different domains, Calabria and Sicily, which are characterized by different crustal motions. The northeastern part of Sicily and Calabria move like Adriatic area, whilst the rest of Sicily, Malta and Lampedusa are dominated by African motion.

  10. Geodetic proof of vertical recent movements at the seism generating zone of Acambay, Mexico

    Directory of Open Access Journals (Sweden)

    Luis Miguel Espinosa-Rodríguez

    2016-12-01

    Full Text Available The central territorial belt oriented west-east and located along the parallel 19 in the Mexican Republic, is composed of a complex system of faults, that respond to the consequent morphology of a tension arched system, which has been erected to the Volcanic Transmexican or Transversal Belt. This region evidences the dynamics and evolution of a graben and horst tectonic system, as well as volcanic manifestations characterized by stratovolcanoes, monogenetic fields and fisural flows, among others. In particular, in the center of the Mexican regional complex, the fault system which delimits the region of Acambay in the state of Mexico, had showed evidences of seismogenerating activity during a century until the present time. According to the above and based on the geomorphological analysis and the geodetic measurements, the dynamic presented by these morphostructures in a multitemporal comparative study (1998/2003 o 2011 is showed. The rates of vertical tectonic movements reflect recent rise values ranging from + 7,3 to 12,8 mm/year in the northern horst of Santa María Tixmadejé, while in the central graben of Acambay are very weak, of the order of + 0,4 to + 0,5 mm/year.

  11. The September 16, 2015 Illapel (Mw 8.3) Earthquake: Comprehensive Analysis from Seismic and Geodetic Observations

    Science.gov (United States)

    Comte, D.; Carrizo, D.; Peyrat, S.; Russo, R. M.; Roecker, S. W.; Opazo, T.; Peña, G.; Baeza, S.; Arriaza, R.; Ortega-Culaciati, F.; Ruiz, J. A.; Contreras-Reyes, E.; Becerra, V.

    2015-12-01

    On September 16th, 2015 an Mw=8.3 struck the Illapel zone between 30°- 32.5°S along an area between the trench and the coastline, including the activation of outer-rise seismicity. The rupture area of this earthquake covers the 1943 previous large earthquake, and also seems to overlap with the northern end of the rupture of the 1971 and 1985 earthquakes. Immediately after the occurrence of the 2015 earthquake, we deployed 18 3-components short period continuous recording seismic stations to complement the coverage of the University of Chile National Seismological Center (CSN) permanent broad band seismic network and four temporary seismic stations deployed by the CSN. The short period stations will be replaced by IRIS PASCAL broad band stations through the NSF RAPID Collaborative Proposal (U. of Florida, RPI, and U. of Chile), generating an open-access data set that, along with the seismological and geodetic observations from CSN permanent networks, provide the best quality data that can be utilized immediately by a wide range of PIs and institutions around the world. Such datasets able us to pursue these main goals: 1) aftershock monitoring, focal mechanism and analysis related with the interplate rupture zone; 2) imaging the seismic structure of the 2015 Illapel rupture area; 3) characterization of the mechanical behavior of the subduction interface from geodetic observations before, during and after the earthquake, 4) identification and characterization of low frequency and/or slow slip aftershocks; characterization of seismic amplification effects and the consequent hazard determination.

  12. Geodetic antenna calibration test in the Antarctic environment

    Science.gov (United States)

    Grejner-Brzezinska, A.; Vazquez, E.; Hothem, L.

    2006-01-01

    TransAntarctic Mountain DEFormation (TAMDEF) Monitoring Network is the NSF-sponsored OSU and USGS project, aimed at measuring crustal motion in the Transantarctic Mountains of Victoria Land using GPS carrier phase measurements. Station monumentation, antenna mounts, antenna types, and data processing strategies were optimized to achieve mm-level estimates for the rates of motion. These data contributes also to regional Antarctic frame definition. Significant amount of data collected over several years allow the investigation of unique aspects of GPS geodesy in Antarctica, to determine how the error spectrum compares to the mid-latitude regions, and to identify the optimum measurement and data processing schemes for Antarctic conditions, in order to test the predicted rates of motion (mm-level w.r.t. time). The data collection for the TAMDEF project was initiated in 1996. The primary antenna used has been the Ashtech L1/L2 Dorne Margolin (D/M) choke ring. A few occupations involved the use of a Trimble D/M choke ring. The data were processed using the antenna calibration data available from the National Geodetic Survey (NGS). The recent developments in new antenna designs that are lighter in weight and lower in cost are being considered as a possible alternative to the bulkier and more expensive D/M choke ring design. In November 2003, in situ testing of three alternative models of L1/L2 antennas was conducted at a site located in the vicinity of McMurdo Station, Antarctica (S77.87, E166.56). The antenna models used in this test were: Ashtech D/M choke ring, Trimble D/M choke ring, Trimble Zephyr, and the NovAtel GPS-702. Two stations, spaced within 30 meters, were used in the test. Both had the characteristics similar to the stations of the TAMDEF network, i.e., the UNAVCO fixed-height, force-centered level mounts with a constant antenna offset were used, ensuring extreme stability of the antenna/ mount/pin set up. During each of the four 3-day test data collection

  13. Establishment of 2000 National Geodetic Control Network of China and It’s Technological Progress

    Directory of Open Access Journals (Sweden)

    CHEN Junyong

    2007-02-01

    Full Text Available Objectives: 2000’ National Geodetic Control Network of China is an important fundamental scientific engineering project in China. It consists of three parts which are establishment of 2000 National GPS Geodetic Network, its combination adjustment with national astro-geodetic network and 2000 National Gravity Fundamental network. It provides the high precise coordinate reference and gravity reference for three dimensional geo-center national coordinates system and gravity system, respectively. Additionally, it provides precise unified geometric and physical geodesy information for the economic construction, the national defense and the scientific research. Methods: 1. The larger number of data are processed in triple networks adjustment of 2000 National GPS Geodetic Network, which are chosen from the GPS monitoring stations, such as grade A, B of national GPS network , grade 1st and 2nd of national GPS network, crustal movement observation network of China, and others crustal deformation monitoring stations. Finally, the data of 2666 GPS stations are used in the data processing of 2000 National GPS Geodetic Network, including 124 external stations and 2542 internal stations. In order to the results of triple networks adjustment are corresponding to that of three dimensional geo-center coordinates system, ITRF 97 and epoch 2000.0 are chosen as the coordinate reference frame and epoch reference, respectively. The methods of “strong reference” and “weak reference” are combined used in the control data selection of triple networks adjustment. The scale and rotation scales are adopted for each sub network. The least square adjustment is firstly adopted in each sub network adjustment. The data of obvious abnormal baselines are found and rejected firstly. And the method of double factor robust estimation is adopted in the data processing. 2. The combined adjustment of 2000 National GPS Geodetic Network and national astro-geodetic network is

  14. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    Directory of Open Access Journals (Sweden)

    Lopez-Saura Pedro

    2009-07-01

    Full Text Available Abstract Background Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC or squamous cell skin carcinomas (SCSC. Methods Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Results Sixteen elder (median 70 years-old patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination, 40% PR (>30% tumor reduction, and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. Conclusion The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Trial registration Current Controlled Trials RPCEC00000052.

  15. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    International Nuclear Information System (INIS)

    Anasagasti-Angulo, Lorenzo; Garcia-Vega, Yanelda; Barcelona-Perez, Silvia; Lopez-Saura, Pedro; Bello-Rivero, Iraldo

    2009-01-01

    Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN) may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC) or squamous cell skin carcinomas (SCSC). Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Sixteen elder (median 70 years-old) patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination), 40% PR (>30% tumor reduction), and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Current Controlled Trials RPCEC00000052

  16. A new unified approach to determine geocentre motion using space geodetic and GRACE gravity data

    Science.gov (United States)

    Wu, Xiaoping; Kusche, Jürgen; Landerer, Felix W.

    2017-06-01

    Geocentre motion between the centre-of-mass of the Earth system and the centre-of-figure of the solid Earth surface is a critical signature of degree-1 components of global surface mass transport process that includes sea level rise, ice mass imbalance and continental-scale hydrological change. To complement GRACE data for complete-spectrum mass transport monitoring, geocentre motion needs to be measured accurately. However, current methods of geodetic translational approach and global inversions of various combinations of geodetic deformation, simulated ocean bottom pressure and GRACE data contain substantial biases and systematic errors. Here, we demonstrate a new and more reliable unified approach to geocentre motion determination using a recently formed satellite laser ranging based geocentric displacement time-series of an expanded geodetic network of all four space geodetic techniques and GRACE gravity data. The unified approach exploits both translational and deformational signatures of the displacement data, while the addition of GRACE's near global coverage significantly reduces biases found in the translational approach and spectral aliasing errors in the inversion.

  17. Geodetical survey concerning the reactor vessel of the Paks nuclear power plant

    International Nuclear Information System (INIS)

    Czellar, A.; Zergi, I.

    1982-01-01

    A geodetical survey concerning the reactor vessel of the Paks nuclear power plant is reported. The accuracy of the position of the joining parts of the vessel to the primary coolant circuit was inspected by photogrammetry and by geodesic measurements applying iteration and traversing. The resulting dimensions of the vessel proved to be within the tolerance of the specified values. (Sz.J.)

  18. Geodetic networks of processing by singular decomposition of the configuration matrix

    Directory of Open Access Journals (Sweden)

    Weiss Gabriel

    1996-12-01

    Full Text Available The paper present a solution of the Gauss-Markov Model for processing geodetic networks with constraints using singular decomposition of the network’s design matrix A. The homogenisation and dehomogenisation of the model needed for this purpose is introduced too. Outputs of the solution are presented by the necessary matrices and upon advantages of this way are discoursed.

  19. Timing of dose relative to sexual intercourse attempt in previous sildenafil citrate users treated with tadalafil: a geographical comparison from a single arm, open-label study.

    Science.gov (United States)

    Rubio-Aurioles, Eusebio; Glina, Sidney; Abdo, Carmita H N; Hernandez-Serrano, Ruben; Rampazzo, Claudia; Sotomayor, Mariano; West, Teena M; Gallagher, Gabrielle L; Lenero, Enrique

    2009-10-01

    Previous research has demonstrated that sildenafil citrate users alter dosing-sexual attempt behavior when switched to tadalafil. The impact of geography and culture on sexual behavior with phosphodiesterase type 5 (PDE5) inhibitor treatment has not been fully investigated. To describe and compare the changes in dosing-sexual attempt behavior with sildenafil citrate vs. tadalafil treatment across four distinct geographies: Asia, Australia/New Zealand (ANZ), Central Eastern Europe/Middle East (CEE/ME), and Latin America (LA). Data from a single-arm, open-label clinical trial conducted in 21 countries from November 2002 to May 2004 were used in this analysis. Men with erectile dysfunction and a history of > or =6-week prior sildenafil citrate use continued sildenafil citrate treatment for 4 weeks then switched to tadalafil for 8 weeks. Dosing instructions were provided. Timing of dose and sexual intercourse was assessed through patient diaries for the final 4 weeks of each treatment period. A total of 2,760 men were enrolled: Asia 15.8%; ANZ 29.4%; CEE/ME 19.7%; LA 35.1%. The median time from dosing to intercourse was significantly increased during tadalafil treatment across all geographical regions; however, the magnitude of increase differed significantly by geography (P geography. However, the extent to which sexual behavior alters is not uniform across geographical regions, suggesting that dosing instructions and duration of drug effectiveness, in combination with personal and cultural preferences, may determine sexual behavior with PDE5 inhibitor use.

  20. Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.

    Science.gov (United States)

    Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M

    1989-12-01

    Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage.

  1. Recommendations for Conducting Differential Item Functioning (DIF) Analyses for Students with Disabilities Based on Previous DIF Studies. Research Report. ETS RR-11-34

    Science.gov (United States)

    Buzick, Heather; Stone, Elizabeth

    2011-01-01

    The purpose of this study is to help ensure that strategies for differential item functioning (DIF) detection for students with disabilities are appropriate and lead to meaningful results. We surveyed existing DIF studies for students with disabilities and describe them in terms of study design, statistical approach, sample characteristics, and…

  2. Prospective monitoring and self-report of previous falls among older women at high risk of falls and fractures: a study of comparison and agreement

    Science.gov (United States)

    Garcia, Patrícia A.; Dias, João M. D.; Silva, Silvia L. A.; Dias, Rosângela C.

    2015-01-01

    Background: The identification of the occurrence of falls is an important step for screening and for rehabilitation processes for the elderly. The methods of monitoring these events are susceptible to recording biases, and the choice of the most accurate method remains challenging. Objectives: (i) To investigate the agreement between retrospective self-reporting and prospective monitoring of methods of recording falls, and (ii) to compare the retrospective self-reporting of falls and the prospective monitoring of falls and recurrent falls over a 12-month period among older women at high risk of falls and fractures. Method: A total of 118 community-dwelling older women with low bone density were recruited. The incidence of falls was monitored prospectively in 116 older women (2 losses) via monthly phone calls over the course of a year. At the end of this monitoring period, the older women were asked about their recall of falls in the same 12-month period. The agreement between the two methods was analyzed, and the sensitivity and specificity of self-reported previous falls in relation to the prospective monitoring were calculated. Results: There was moderate agreement between the prospective monitoring and the retrospective self-reporting of falls in classifying fallers (Kappa=0.595) and recurrent fallers (Kappa=0.589). The limits of agreement were 0.35±1.66 falls. The self-reporting of prior falls had a 67.2% sensitivity and a 94.2% specificity in classifying fallers among older women and a 50% sensitivity and a 98.9% specificity in classifying recurrent fallers. Conclusion: Self-reporting of falls over a 12-month period underestimated 32.8% of falls and 50% of recurrent falls. The findings recommend caution if one is considering replacing monthly monitoring with annual retrospective questioning. PMID:26083603

  3. Long-term clinical and economic outcomes in previously untreated paediatric patients with severe haemophilia A: A nationwide real-world study with 700 person-years.

    Science.gov (United States)

    Vepsäläinen, K; Riikonen, P; Lassila, R; Arola, M; Huttunen, P; Lähteenmäki, P; Möttönen, M; Selander, T; Martikainen, J

    2018-03-01

    For previously untreated patients (PUPs) with severe haemophilia A in Finland for the past 2 decades, the standard practice has been to start early primary prophylaxis. We evaluated the long-term clinical outcomes and costs of treatment with high-dose prophylaxis in PUPs from birth to adolescence, including immune tolerance induction (ITI). From the medical records of all PUPs born between June 1994 and May 2013 in Finland, we retrospectively extracted data on clinical outcomes and healthcare use. Using linear mixed models, we analysed longitudinal clinical outcome data. To analyse skewed cost data, including zero costs, we applied hurdle regression. All 62 patients received early regular prophylaxis; totally, they have had treatment for nearly 700 patient-years. The median age of starting home treatment was 1.1 years. The mean (SD) annual treatment costs (€ per kg) were 4391€ (3852). For ages 1-3, ITI comprised over half of the costs; in other groups, prophylactic FVIII treatment dominated. With these high costs, however, clinical outcomes were desirable; median (IQR) ABR was low at 0.19 (0.07-0.46) and so was AJBR at 0.06 (0-0.24). Thirteen (21%) patients developed a clinically significant inhibitor, 10 (16%) with a high titre. All ITIs were successful. The mean costs for ITI were 383 448€ (259 085). The expected ITI payback period was 1.81 (95% CI 0.62-12.12) years. Early high-dose prophylaxis leads to excellent long-term clinical outcomes, and early childhood ITI therapy seems to turn cost-neutral generally already in 2 years. © 2018 John Wiley & Sons Ltd.

  4. Placental complications after a previous cesarean section

    OpenAIRE

    Milošević Jelena; Lilić Vekoslav; Tasić Marija; Radović-Janošević Dragana; Stefanović Milan; Antić Vladimir

    2009-01-01

    Introduction The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complic...

  5. SIRGAS: the core geodetic infrastructure in Latin America and the Caribbean

    Science.gov (United States)

    Sanchez, L.; Brunini, C.; Drewes, H.; Mackern, V.; da Silva, A.

    2013-05-01

    Studying, understanding, and modelling geophysical phenomena, such as global change and geodynamics, require geodetic reference frames with (1) an order of accuracy higher than the magnitude of the effects we want to study, (2) consistency and reliability worldwide (the same accuracy everywhere), and (3) a long-term stability (the same order of accuracy at any time). The definition, realisation, maintenance, and wide-utilisation of the International Terrestrial Reference System (ITRS) are oriented to guarantee a globally unified geometric reference frame with reliability at the mm-level, i.e. the International Terrestrial Reference Frame (ITRF). The densification of the global ITRF in Latin America and The Caribbean is given by SIRGAS (Sistema de Referencia Geocéntrico para Las Américas), primary objective of which is to provide the most precise coordinates in the region. Therefore, SIRGAS is the backbone for all regional projects based on the generation, use, and analysis of geo-referenced data at national as well as at international level. Besides providing the reference for a wide range of scientific applications such as the monitoring of Earth's crust deformations, vertical movements, sea level variations, atmospheric studies, etc., SIRGAS is also the platform for practical applications such as engineering projects, digital administration of geographical data, geospatial data infrastructures, etc. According to this, the present contribution describes the main features of SIRGAS, giving special care to those challenges faced to continue providing the best possible, long-term stable and high-precise reference frame for Latin America and the Caribbean.

  6. Monitoring Coastal Embankment Subsidence and Relative Sea Level Rise in Coastal Bangladesh Using Satellite Geodetic Data

    Science.gov (United States)

    Guo, Q.; Shum, C. K.; Jia, Y.; Yi, Y.; Zhu, K.; Kuo, C. Y.; Liibusk, A.

    2015-12-01

    The Bangladesh Delta is located at the confluence of the mega Ganges, Brahmaputra and Meghan Rivers in the Bay of Bengal. It is home to over 160 million people and is one of the most densely populated countries in the world. It is prone to seasonal transboundary monsoonal flooding, potentially aggravated by more frequent and intensified cyclones resulting from anthropogenic climate change. Sea level rise, along with tectonic, sediment compaction/load and groundwater extraction induced land uplift/subsidence, have significantly exacerbated these risks and Bangladesh's coastal vulnerability. Bangladesh has built 123 coastal embankments or polders since the 1960's, to protect the coastal regions from cyclone/tidal flooding and to reduce salinity incursions. Since then, many coastal polders have suffered severe erosion and anthropogenic damage, and require repairs or rebuilding. However, the physical and anthropogenic processes governing the historic relative sea level rise and its future projection towards its quantification remain poorly understood or known, and at present not accurate enough or with an adequately fine local spatial scale for practical mitigation of coastal vulnerability or coastal resilience studies. This study reports on our work in progress to use satellite geodetic and remote sensing observations, including satellite radar altimetry/backscatter measurements over land and in coastal oceans, optical/infrared imageries, and SAR backscatter/InSAR data, to study the feasibility of coastal embankment/polder erosion monitoring, quantify seasonal polder water intrusions, observing polder subsidence, and finally, towards the goal of improving the relative sea level rise hazards assessment at the local scale in coastal Bangladesh.

  7. Performance of the high-resolution atmospheric model HRRR-AK for correcting geodetic observations from spaceborne radars.

    Science.gov (United States)

    Gong, W; Meyer, F J; Webley, P; Morton, D

    2013-10-27

    [1] Atmospheric phase delays are considered to be one of the main performance limitations for high-quality satellite radar techniques, especially when applied to ground deformation monitoring. Numerical weather prediction (NWP) models are widely seen as a promising tool for the mitigation of atmospheric delays as they can provide knowledge of the atmospheric conditions at the time of Synthetic Aperture Radar data acquisition. However, a thorough statistical analysis of the performance of using NWP production in radar signal correction is missing to date. This study provides a quantitative analysis of the accuracy in using operational NWP products for signal delay correction in satellite radar geodetic remote sensing. The study focuses on the temperate, subarctic, and Arctic climate regions due to a prevalence of relevant geophysical signals in these areas. In this study, the operational High Resolution Rapid Refresh over the Alaska region (HRRR-AK) model is used and evaluated. Five test sites were selected over Alaska (AK), USA, covering a wide range of climatic regimes that are commonly encountered in high-latitude regions. The performance of the HRRR-AK NWP model for correcting absolute atmospheric range delays of radar signals is assessed by comparing to radiosonde observations. The average estimation accuracy for the one-way zenith total atmospheric delay from 24 h simulations was calculated to be better than ∼14 mm. This suggests that the HRRR-AK operational products are a good data source for spaceborne geodetic radar observations atmospheric delay correction, if the geophysical signal to be observed is larger than 20 mm.

  8. A Comparative Study of the Previously Graduated Dentists' Knowledge versus those Recently Graduated as to Proper Prescription of Interaoral Radiography and Panoramic Views

    OpenAIRE

    Bardal R.; Rahimi R.; Ahmadi Motamayel F.

    2011-01-01

    Statement of Problems: The first step to decrease the patients' exposure to unnecessary radiography radiation is the proper prescription of radiography. . Purpose: The purpose of this study was to evaluate the knowledge of general dental practitioners as to proper prescription of intraoral radiography and panoramic views. Materials and Method: In this study, a questionnaire on the dentists' knowledge about the proper prescription of dental radiography was used. A total of eighty one general d...

  9. The change in motivating factors influencing commencement, adherence and retention to a supervised resistance training programme in previously sedentary post-menopausal women: a prospective cohort study.

    Science.gov (United States)

    Viljoen, Janet Erica; Christie, Candice Jo-Anne

    2015-03-12

    Understanding motivators for exercise participation in post-menopausal women may impact retention to exercise programmes and inform intervention trial designs. The purpose of this investigation was to assess self-reported motivational factors influencing adherence and retention to a 24-week progressive resistance training programme. Post-menopausal females (n = 34) were passively recruited to undertake a 24-week progressive resistance training protocol, in small-group sessions, on three non-consecutive days of the week. Attendance was recorded by the researcher. Qualitative reports were sourced from the sample for four phases of the study: pre-study (prior to week 1), recruitment (week 1), during study (weeks 2 - 24), and post-intervention (beyond week 24). Responses were categorised according to ten descriptors: specific health index improvement, education, flexibility of time, social contact, conscience (loyalty to the researcher), wellness, weight management, organisation parameters (pertaining to the study programme) and enjoyment of the exercises. Of the initial sample, 76.5% (n = 26) met the specified ≥80% attendance criterion. The primary findings were that motivation to volunteer for the study was driven by a perceived need for a structured exercise programme (50% of respondents). A commitment to the researcher was the primary motivator for continued adherence to the study for 50% of participants. Social contact with other participants was cited by 60% of the sample as the primary reason for adherence for the full duration of 24 weeks. A desire to maintain the "wellness" derived from the programme was cited by 60% as a reason for continuing an exercise routine post-study. This study identified that routine and supervision initially attract women to exercise programmes, while social cohesion of the group setting contributes to retention over time. Understanding the changing nature of motivating factors may contribute to better overall adherence

  10. Geodetic Mass Balance of the Northern Patagonian Icefield from 2000 to 2012 Using Two Independent Methods

    Directory of Open Access Journals (Sweden)

    Inés Dussaillant

    2018-02-01

    Full Text Available We compare two independent estimates of the rate of elevation change and geodetic mass balance of the Northern Patagonian Icefield (NPI between 2000 (3,856 km2 and 2012 (3,740 km2 from space-borne data. The first is obtained by differencing the Shuttle Radar Topography Mission (SRTM digital elevation model (DEM from February 2000 and a Satellite pour l'Observation de la Terre 5 (SPOT5 DEM from March 2012. The second is deduced by fitting pixel-based linear elevation trends over 118 DEMs calculated from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER stereo images acquired between 2000 and 2012. Both methods lead to similar and strongly negative icefield-wide mass balance rates of −1.02 ± 0.21 and −1.06 ± 0.14 m w.e. yr−1 respectively, which is in agreement with earlier studies. Contrasting glacier responses are observed, with individual glacier mass balance rates ranging from −0.15 to −2.30 m w.e. yr−1 (standard deviation = 0.49 m w.e. yr−1; N = 38. For individual glaciers, the two methods agree within error bars, except for small glaciers poorly sampled in the SPOT5 DEM due to clouds. Importantly, our study confirms the lack of penetration of the C-band SRTM radar signal into the NPI snow and firn except for a region above 2,900 m a.s.l. covering <1% of the total area. Ignoring penetration would bias the mass balance by only 0.005 m w.e. yr−1. A strong advantage of the ASTER method is that it relies only on freely available data and can thus be extended to other glacierized areas.

  11. Chinese Digital Zenith Telescope (DZT) used for Astro-geodetic Deflection of the Vertical Determination

    Science.gov (United States)

    Tian, L.; Wang, B.; Wang, Z.; Yin, Z.; Hu, H.; Wang, H.; Han, Y.

    2015-12-01

    Classical optical astrometry can be used to measure and study variations of plumb line. For the earth gravity filed related researches, it is irreplaceable by technologies like GNSS、VLBI、SLR, etc. However, classical astrometric instruments have some major drawback, such as low efficiency, low automation, more operating observers, and individual error in some visual instruments. In 2011, The National Astronomical Observatories of the Chinese Academy of Sciences (NAOC) successfully developed the new digital zenith telescope prototype (DZT-1), which has the ability of highly automatic observation and data processing, even allowing unattended observation by remote control. By utilizing CCD camera as imaging terminal and high-accuracy tiltmeter to replace mercurial plate, observation efficiency of DZT is improved greatly. According to the results of data obtained from test observations, single-observation accuracy of DZT-1 is 0.15-0.3″ and one night observation accuracy up to 0.07-0.08″, which is better than the observation accuracy of classical astrometric instruments. The observations of DZT can be used to obtain the plumb line variations and the vertical deflections, which can be used for carrying out seismic, geodetic and other related geo-scientific researches. Especially the collocated observations with gravimeters and the conjoint analysis of the observation data will be helpful to recognize the anomalous motion and variation of underground mass over time, and maybe provide significant information for estimating the scale of underground anomalous mass. The information is valuable for determining the three key factors of earthquake possibly. Moreover, the project team is carrying out the development of new DZT with better performance and studying the key techniques for new instrument to make DZT play a more significant role in the astronomy and geoscience fields.

  12. Integrating Geological and Geodetic Surveying Techniques for Landslide Deformation Monitoring: Istanbul Case

    Science.gov (United States)

    Menteşe, E. Y.; Kilic, O.; BAS, M.; Tarih, A.; Duran, K.; Gumus, S.; Yapar, E. R.; Karasu, M. E.; Mehmetoğlu, H.; Karaman, A.; Edi˙ger, V.; Kosma, R. C.; Ozalaybey, S.; Zor, E.; Arpat, E.; Polat, F.; Dogan, U.; Cakir, Z.; Erkan, B.

    2017-12-01

    There are several methods that can be utilized for describing the landslide mechanisms. While some of them are commonly used, there are relatively new methods that have been proven to be useful. Obviously, each method has its own limitations and thus integrated use of these methods contributes to obtaining a realistic landslide model. The slopes of Küçükçekmece and Büyükçekmece Lagoons located at the Marmara Sea coast of İstanbul, Turkey, are among most specific examples of complex type landslides. The landslides in the area started developing at low sea level, and appears to ceased or at least slowed down to be at minimum after the sea level rise, as oppose to the still-active landslides that continue to cause damage especially in the valley slopes above the recent sea level between the two lagoons. To clarify the characteristics of these slope movements and classify them in most accurate way, Directorate of Earthquake and Ground Research of Istanbul Metropolitan Municipality launched a project in cooperation with Marmara Research Center of The Scientific and Technological Research Council of Turkey (TÜBİTAK). The project benefits the utility of the techniques of different disciplines such as geology, geophysics, geomorphology, hydrogeology, geotechnics, geodesy, remote sensing and meteorology. Specifically, this study focuses on two main axes of these techniques, namely: geological and geodetic. The reason for selecting these disciplines is because of their efficiency and power to understand the landslide mechanism in the area. Main approaches used in these studies are comprised of geological drills, inclinometer measurements, GPS surveys and SAR (both satellite and ground based) techniques. Integration of the results gathered from these techniques led the project team to comprehend critical aspects of landslide phenomenon in the area and produce precise landslide hazard maps that are basic instruments for a resilient urban development.

  13. The possibility of previous epidemiological data to serve as baseline for future national oral health surveys--a study in Vietnam.

    NARCIS (Netherlands)

    Palenstein Helderman, W.H. van; Truin, G.J.; Can, N.; Khanh, N.D.

    2001-01-01

    AIM: The purpose of this paper is to review the most recent epidemiological data (1985-2000) on dental caries and periodontal diseases in Vietnam in an attempt to obtain a 'baseline' for future national oral health surveys. METHODS: Studies on periodontal diseases and caries were included when CPITN

  14. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

    DEFF Research Database (Denmark)

    Forner, Lone; Hansen, Ole Hyldegaard; von Brockdorff, Annet Schack

    2011-01-01

    Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO...

  15. Alfalfa (Medicago sativa L.) is tolerant to higher levels of salinity than previous guidelines indicated: Implications of field and greenhouse studies

    Science.gov (United States)

    Putnam, Daniel H.; Benes, Sharon; Galdi, Giuliano; Hutmacher, Bob; Grattan, Steve

    2017-04-01

    Alfalfa (Medicago sativa L.) is the most widely grown leguminous forage crop in North America and is valued for high productivity, quality, economic value, and for dairy productivity. Alfalfa has historically been classified as moderately sensitive to saline conditions, with yield declines predicted at >2 dS/m in the saturated soil paste extract. However, greenhouse, sand tank, and field studies over the past five years have confirmed that alfalfa can be grown with limited negative effects at much higher salinity levels. A broad collection of alfalfa varieties has exhibited a range of resistance at irrigation water salinities >5 dS/m ECw in greenhouse trials, with significant variation due to variety. USDA-ARS sand tank studies indicated similar or greater tolerances closer to 8 dS/m in the soil water, in addition to confirmation of significant varietal differences. A three-year field study on clay loam soil with applications of 5-7 dS/m ECw irrigation water indicated normal yields and excellent stand survivability. A second field study in the same soil type with levels from 8-10 dS/m ECw showed yield reductions of 10-15% but economic yields were still achieved at those levels. Field and greenhouse studies were conducted with mixed salt saline sodic waters typical of the San Joaquin Valley of California. Field evaluation of variety performance was subject to greater variation due to secondary salinity-soil interactions including water infiltration and crusting problems, not only salinity per-se. Thus, adequate irrigation water availability to the crop may be as important as salinity in impacting yields under field conditions. Once established, the deep-rooted characteristics of alfalfa enable utilization of deeper subsurface moisture, even at moderate to high salinity levels, as documented by USDA lysimeter studies. Significant advantages to salinity-tolerant varieties have been observed. It will be important to consider specific management factors which may enable

  16. Effect of benzalkonium chloride?free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study

    OpenAIRE

    Lopes, Joao F.; Hubatsch, Douglas A.; Amaris, Patricia

    2015-01-01

    Background Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). Methods This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005?% were transitioned to recei...

  17. A study of tectonic activity in the Basin-Range Province and on the San Andreas Fault. No. 3: Kinematics of Great Basin intraplate extension from earthquake, geodetic and geologic information. Final Technical Report, 15 Apr. 1981 - 31 Jan. 1986 M.S. Thesis

    Science.gov (United States)

    Eddington, P. K.

    1986-01-01

    Strain rates assessed from brittle fracture, associated with earthquakes, and total brittle-ductile deformation measured from geodetic data were compared to paleostrain from Quaternary geology for the intraplate Great Basin of the western United States. These data provide an assessment of the kinematics and mode of lithospheric extension that the western U.S. Cordillera has experienced in the last 5 to 10 million years. Strain and deformation rates were determined by the seismic moment tensor method using historic seismicity and fault plane solutions. Contemporary deformation of the Great Basin occurs principally along the active seismic zones. The earthquake related strain shows that the Great Basin is characterized by regional E-W extension at 8.4 mm/a in the north that diminishes to NW-SE extension of 3.5 mm/a in the south. Zones of maximum extension correspond to belts of shallow crust, high heat flow, and Quaternary basaltic volcanism, suggesting that these parameters are related through an effect such as a stress relaxation allowing bouyant uplift and ascension of magmas.

  18. A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia.

    Directory of Open Access Journals (Sweden)

    Aaron D Schimmer

    Full Text Available An open-label phase I/II study of single-agent obatoclax determined a maximum tolerated dose (MTD and schedule, safety, and efficacy in older patients (≥ 70 yr with untreated acute myeloid leukemia (AML.Phase I evaluated the safety of obatoclax infused for 3 hours on 3 consecutive days (3 h × 3 d in 2-week cycles. Initial obatoclax dose was 30 mg/day (3 h × 3 d; n = 3. Obatoclax was increased to 45 mg/day (3 h × 3 d if ≤ 1 patient had a dose-limiting toxicity (DLT and decreased to 20 mg/day (3 h × 3 d if DLT occurred in ≥ 2 patients. In the phase II study, 12 patients were randomized to receive obatoclax at the dose identified during phase I (3 h × 3 d or 60 mg/day administered by continuous infusion over 24 hours for 3 days (24 h × 3 d to determine the morphologic complete response rate.In phase I, two of three patients receiving obatoclax 30 mg/day (3 h × 3 d experienced grade 3 neurologic DLTs (confusion, ataxia, and somnolence. Obatoclax was decreased to 20 mg/day (3 h × 3 d. In phase II, no clinically relevant safety differences were observed between the 20 mg/day (3 h × 3 d; n = 7 and 60 mg/day (24 h × 3 d; n = 5 arms. Neurologic and psychiatric adverse events were most common and were generally transient and reversible. Complete response was not achieved in any patient.Obatoclax 20 mg/day was the MTD (3 h × 3 d in older patients with AML. In the schedules tested, single-agent obatoclax was not associated with an objective response. Evaluation in additional subgroups or in combination with other chemotherapy modalities may be considered for future study.ClinicalTrials.gov NCT00684918.

  19. A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia.

    Science.gov (United States)

    Schimmer, Aaron D; Raza, Azra; Carter, Thomas H; Claxton, David; Erba, Harry; DeAngelo, Daniel J; Tallman, Martin S; Goard, Carolyn; Borthakur, Gautam

    2014-01-01

    An open-label phase I/II study of single-agent obatoclax determined a maximum tolerated dose (MTD) and schedule, safety, and efficacy in older patients (≥ 70 yr) with untreated acute myeloid leukemia (AML). Phase I evaluated the safety of obatoclax infused for 3 hours on 3 consecutive days (3 h × 3 d) in 2-week cycles. Initial obatoclax dose was 30 mg/day (3 h × 3 d; n = 3). Obatoclax was increased to 45 mg/day (3 h × 3 d) if ≤ 1 patient had a dose-limiting toxicity (DLT) and decreased to 20 mg/day (3 h × 3 d) if DLT occurred in ≥ 2 patients. In the phase II study, 12 patients were randomized to receive obatoclax at the dose identified during phase I (3 h × 3 d) or 60 mg/day administered by continuous infusion over 24 hours for 3 days (24 h × 3 d) to determine the morphologic complete response rate. In phase I, two of three patients receiving obatoclax 30 mg/day (3 h × 3 d) experienced grade 3 neurologic DLTs (confusion, ataxia, and somnolence). Obatoclax was decreased to 20 mg/day (3 h × 3 d). In phase II, no clinically relevant safety differences were observed between the 20 mg/day (3 h × 3 d; n = 7) and 60 mg/day (24 h × 3 d; n = 5) arms. Neurologic and psychiatric adverse events were most common and were generally transient and reversible. Complete response was not achieved in any patient. Obatoclax 20 mg/day was the MTD (3 h × 3 d) in older patients with AML. In the schedules tested, single-agent obatoclax was not associated with an objective response. Evaluation in additional subgroups or in combination with other chemotherapy modalities may be considered for future study. ClinicalTrials.gov NCT00684918.

  20. Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study.

    Science.gov (United States)

    Lopes, Joao F; Hubatsch, Douglas A; Amaris, Patricia

    2015-11-12

    Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005 % were transitioned to receive once-daily BAK-free travoprost 0.004 % containing polyquaternium-1 (Travatan® preserved with POLYQUAD® [PQ], Alcon Laboratories, Inc; Fort Worth, TX) for 12 weeks. Mean change in IOP from baseline (primary efficacy endpoint) and the percentage of patients who achieved a target IOP of ≤18 mmHg were evaluated at all on-therapy visits. Ocular hyperemia, patient preference, and self-projected adherence were assessed at week 12. Adverse events (AEs) were monitored throughout the study. All enrolled patients were included in the analysis (n = 191); the majority of patients (90.6 %, n = 173/191) completed the study. Mean (SD) patient age was 67.5 (11.3) years, and mean baseline IOP was 14.8 mmHg. Mean IOP was reduced by 0.94 mmHg at week 6 and by 1.09 mmHg at week 12 (P glaucoma or ocular hypertension who were intolerant of latanoprost. BAK-free travoprost 0.004 % is a viable alternative for patients who require switching their IOP-lowering medications because of tolerability issues. ClinicalTrials.gov identifier, NCT01510145.

  1. Tendon Length, Calf Muscle Atrophy, and Strength Deficit After Acute Achilles Tendon Rupture: Long-Term Follow-up of Patients in a Previous Study.

    Science.gov (United States)

    Heikkinen, Juuso; Lantto, Iikka; Piilonen, Juuso; Flinkkilä, Tapio; Ohtonen, Pasi; Siira, Pertti; Laine, Vesa; Niinimäki, Jaakko; Pajala, Ari; Leppilahti, Juhana

    2017-09-20

    In this prospective study, we used magnetic resonance imaging (MRI) to assess long-term Achilles tendon length, calf muscle volume, and muscle fatty degeneration after surgery for acute Achilles tendon rupture. From 1998 to 2001, 60 patients at our center underwent surgery for acute Achilles tendon rupture followed by early functional postoperative rehabilitation. Fifty-five patients were reexamined after a minimum duration of follow-up of 13 years (mean, 14 years), and 52 of them were included in the present study. Outcome measures included Achilles tendon length, calf muscle volume, and fatty degeneration measured with MRI of both the affected and the uninjured leg. The isokinetic plantar flexion strength of both calves was measured and was correlated with the structural findings. The Achilles tendon was, on average, 12 mm (95% confidence interval [CI] = 8.6 to 15.6 mm; p muscles were 63 cm (13%; p muscle atrophy. Increased Achilles tendon length is associated with smaller calf muscle volumes and persistent plantar flexion strength deficits after surgical repair of Achilles tendon rupture. Strength deficits and muscle volume deficits are partly compensated for by FHL hypertrophy, but 11% to 13% deficits in soleus and gastrocnemius muscle volumes and 12% to 18% deficits in plantar flexion strength persist even after long-term follow-up. Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

  2. Outcomes following detection of low level plasma HIV RNA in HIV-infected patients previously virologically suppressed on antiretroviral therapy: a retrospective observational study.

    Science.gov (United States)

    Warren, Annabelle M; Cheng, Allen C; Watson, Kerrie; Lewin, Sharon R; Hoy, Jennifer F

    2017-06-01

    Progressively sensitive assays for plasma HIV RNA have led to increased detection of plasma HIV RNA between 20 and 200 copies/ml, known as low level viremia (LLV) when recurrent or persistent, in HIV-infected patients on antiretroviral therapy (ART). The aim of this study was to determine outcomes following initial detection of LLV in an Australian cohort. A retrospective study using the HIV Service Database (Alfred Hospital) included all patients on ART who recorded plasma HIV RNA 20-200 copies/mL following prior virological suppression (viral load (VL) HIV RNA 200 copies/mL. Factors associated with LLV included co-morbid type 2 diabetes, shorter prior virological suppression and lower nadir CD4 cell count. Clinician management of VL 20-200 copies/mL was generally conservative, with infrequent requests for genotypic analysis (3.3% cases) or change in ART (<1% cases). LLV following virological suppression is common, and occurred as an isolated viral blip in half the patients. Those patients with persistent or recurrent LLV had higher rates of type 2 diabetes, shorter prior virological suppression and lower nadir CD4 cell count.

  3. Responses to A(H1N1)pdm09 influenza vaccines in participants previously vaccinated with seasonal influenza vaccine: a randomized, observer-blind, controlled study.

    Science.gov (United States)

    Roy-Ghanta, Sumita; Van der Most, Robbert; Li, Ping; Vaughn, David W

    2014-11-01

    Prior receipt of a trivalent seasonal influenza vaccine (TIV) can affect hemagglutination inhibition (HI) antibody responses to pandemic influenza vaccines. We investigated the effect of TIV priming on humoral responses to AS03-adjuvanted and nonadjuvanted A(H1N1)pdm09 vaccines, the role of AS03 on cell-mediated immune (CMI) responses, and vaccine safety. Healthy adults (aged 19-40 years) were randomized 1:1:1:1 to receive TIV or saline followed 4 months later by 2 doses, 3 weeks apart, of adjuvanted or nonadjuvanted A(H1N1)pdm09 vaccine and followed up to study end (day 507). Pre- and postvaccination responses of HI and neutralizing antibody, CD4(+)/CD8(+) T cells, memory B cells, and plasmablasts were assessed. Ninety-nine of the 133 participants enrolled completed the study. No vaccine-related serious adverse events were recorded. In TIV-primed participants, A(H1N1)pdm09-specific antibody and CD4(+) T-cell and memory B-cell responses to the pandemic vaccine tended to be diminished. Vaccine adjuvantation led to increased responses of vaccine-homologous and -heterologous HI and neutralizing antibodies and CD4(+) T cells, homologous memory B cells, and plasmablasts. In healthy adults, prior TIV administration decreased humoral and CMI responses to A(H1N1)pdm09 vaccine. Adjuvantation of A(H1N1)pdm09 antigen helped to overcome immune interference between the influenza vaccines. No safety concerns were observed. Clinical Trials.gov identifier NCT00707967. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

  4. Responses to A(H1N1)pdm09 Influenza Vaccines in Participants Previously Vaccinated With Seasonal Influenza Vaccine: A Randomized, Observer-Blind, Controlled Study

    Science.gov (United States)

    Roy-Ghanta, Sumita; Van der Most, Robbert; Li, Ping; Vaughn, David W.

    2014-01-01

    Background. Prior receipt of a trivalent seasonal influenza vaccine (TIV) can affect hemagglutination inhibition (HI) antibody responses to pandemic influenza vaccines. We investigated the effect of TIV priming on humoral responses to AS03-adjuvanted and nonadjuvanted A(H1N1)pdm09 vaccines, the role of AS03 on cell-mediated immune (CMI) responses, and vaccine safety. Methods. Healthy adults (aged 19–40 years) were randomized 1:1:1:1 to receive TIV or saline followed 4 months later by 2 doses, 3 weeks apart, of adjuvanted or nonadjuvanted A(H1N1)pdm09 vaccine and followed up to study end (day 507). Pre- and postvaccination responses of HI and neutralizing antibody, CD4+/CD8+ T cells, memory B cells, and plasmablasts were assessed. Results. Ninety-nine of the 133 participants enrolled completed the study. No vaccine-related serious adverse events were recorded. In TIV-primed participants, A(H1N1)pdm09-specific antibody and CD4+ T-cell and memory B-cell responses to the pandemic vaccine tended to be diminished. Vaccine adjuvantation led to increased responses of vaccine-homologous and -heterologous HI and neutralizing antibodies and CD4+ T cells, homologous memory B cells, and plasmablasts. Conclusions. In healthy adults, prior TIV administration decreased humoral and CMI responses to A(H1N1)pdm09 vaccine. Adjuvantation of A(H1N1)pdm09 antigen helped to overcome immune interference between the influenza vaccines. No safety concerns were observed. Registration. Clinical Trials.gov identifier NCT00707967. PMID:24864125

  5. [Coming-out, support from family of origin and relationship adjustment of lesbian mothers whose children were born in a previous heterosexual relationship: an exploratory study].

    Science.gov (United States)

    Vyncke, Johanna D; Julien, Danielle

    2005-01-01

    Lesbian couples differ from heterosexual couples in that they must develop their relationship within an environment that is generally unsympathetic to homosexuality, a fact that could accentuate the importance of family support. Furthermore, the disclosure of their sexual orientation by lesbian couples could also affect the support given by family members. The present study examines the effect of coming-out and family support on the relationship adjustment of lesbian mothers whose children were born within a heterosexual context. It was expected that family support would mediate the relationship between coming-out and relationship adjustment. Fifty-five lesbian mothers currently in a relationship answered questions about their perception of family support, on their coming-out behaviour and their relationship adjustment. Results revealed a positive relationship between coming-out and family support, and between family support and relationship adjustment, however no association was found between coming-out and relationship adjustment. The mediation model was therefore not confirmed. Finally, the authors discuss the implications of these results.

  6. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study

    International Nuclear Information System (INIS)

    Weber, Damien C; Miralbell, Raymond; Wang, Hui; Cozzi, Luca; Dipasquale, Giovanna; Khan, Haleem G; Ratib, Osman; Rouzaud, Michel; Vees, Hansjoerg; Zaidi, Habib

    2009-01-01

    A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT. Plans for RA, IMRT and IMPT were optimized for 7 patients. Prescribed dose was 56 Gy in 14 fractions. The recurrent gross tumor volume (GTV) was defined on 18 F-fluorocholine PET/CT scans. Plans aimed to cover at least 95% of the planning target volume with a dose > 50.4 Gy. A maximum dose (D Max ) of 61.6 Gy was allowed to 5% of the GTV. For the urethra, D Max was constrained to 37 Gy. Rectal D Median was < 17 Gy. Results were analyzed using Dose-Volume Histogram and conformity index (CI 90 ) parameters. Tumor coverage (GTV and PTV) was improved with RA (V 95% 92.6 ± 7.9 and 83.7 ± 3.3%), when compared to IMRT (V 95% 88.6 ± 10.8 and 77.2 ± 2.2%). The corresponding values for IMPT were intermediate for the GTV (V 95% 88.9 ± 10.5%) and better for the PTV (V 95% 85.6 ± 5.0%). The percentages of rectal and urethral volumes receiving intermediate doses (35 Gy) were significantly decreased with RA (5.1 ± 3.0 and 38.0 ± 25.3%) and IMPT (3.9 ± 2.7 and 25.1 ± 21.1%), when compared to IMRT (9.8 ± 5.3 and 60.7 ± 41.7%). CI 90 was 1.3 ± 0.1 for photons and 1.6 ± 0.2 for protons. Integral Dose was 1.1 ± 0.5 Gy*cm 3 *10 5 for IMPT and about a factor three higher for all photon's techniques. RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk

  7. GOZCARDS Source Data for Nitric Acid Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Nitric Acid Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpHNO3) contains zonal means and related...

  8. GOZCARDS Source Data for Hydrogen Chloride Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Hydrogen Chloride Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpHCl) contains zonal means and related...

  9. GOZCARDS Source Data for Water Vapor Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Water Vapor Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpH2O) contains zonal means and related...

  10. GOZCARDS Source Data for Nitrous Oxide Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Nitrous Oxide Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpN2O) contains zonal means and related...

  11. GOZCARDS Source Data for Temperature Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid V1.00

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Temperature Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpT) contains zonal means and related...

  12. GOZCARDS Source Data for Ozone Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Ozone Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpO3) contains zonal means and related information...

  13. Global geodetic observing system meeting the requirements of a global society on a changing planet in 2020

    CERN Document Server

    Plag, Hans-Peter

    2009-01-01

    Geodesy plays a key role in geodynamics, geohazards, the global water cycle, global change, atmosphere and ocean dynamics. This book covers geodesy's contribution to science and society and identifies user needs regarding geodetic observations and products.

  14. GOZCARDS Merged Data for Nitrous Oxide Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Nitrous Oxide Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpN2O) contains zonal means and related...

  15. GOZCARDS Merged Data for Water Vapor Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Water Vapor Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpH2O) contains zonal means and related...

  16. GOZCARDS Merged Data for Hydrogen Chloride Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Hydrogen Chloride Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpHCl) contains zonal means and related...

  17. GOZCARDS Merged Data for Ozone Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Ozone Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpO3) contains zonal means and related information...

  18. GOZCARDS Merged Data for Nitric Acid Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Nitric Acid Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpHNO3) contains zonal means and related...

  19. Agile Big Data Analytics of High-Volume Geodetic Data Products for Improving Science and Hazard Response

    Data.gov (United States)

    National Aeronautics and Space Administration — Geodetic imaging is revolutionizing geophysics, but the scope of discovery has been limited by labor-intensive technological implementation of the analyses. The...

  20. 2011 NOAA National Geodetic Survey (NGS) Lidar: Fire Island, NY and Cape May to Absecon Inlet, NJ

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data were collected by the National Oceanic Atmospheric Administration National Geodetic Survey Remote Sensing Division using a Riegl Q680i-D system. The data...

  1. Research Article. Towards a tidal loading model for the Argentine-German Geodetic Observatory (La Plata)

    Science.gov (United States)

    Richter, A.; Müller, L.; Marderwald, E.; Mendoza, L.; Kruse, E.; Perdomo, R.; Scheinert, M.; Perdomo, S.

    2017-02-01

    We present a regionalized model of ocean tidal loading effects for the Argentine-German Geodetic Observatory in La Plata. It provides the amplitudes and phases of gravity variations and vertical deformation for nine tidal constituents to be applied as corrections to the observatory's future geodetic observation data. This model combines a global ocean tide model with a model of the tides in the Río de la Plata estuary. A comparison with conventional predictions based only on the global ocean tide model reveals the importance of the incorporation of the regional tide model. Tidal loading at the observatory is dominated by the tides in the Atlantic Ocean. An additional contribution of local tidal loading in channels and groundwater is examined. The magnitude of the tidal loading is also reviewed in the context of the effects of solid earth tides, atmospheric loading and non-tidal loads.

  2. Review of previous geophysical and geological studies

    Digital Repository Service at National Institute of Oceanography (India)

    Levchenko, O.V.; Neprochnov, Y.P.; Rao, D.G.; Subrahmanyam, C.; Murthy, K.S.R.

    stream_size 5 stream_content_type text/plain stream_name Mem_Geol_Soc_India_39_5.pdf.txt stream_source_info Mem_Geol_Soc_India_39_5.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  3. Interior structure of terrestrial planets: Modeling Mars’ mantle andits electromagnetic, geodetic, and seismic properties

    OpenAIRE

    Verhoeven, Olivier; Rivoldini, A.; Vacher, P.; Mocquet, A.; Choblet, G.; Menvielle, Michel; Dehant, V.; Van Hoolst, T.; Sleewaegen, J.; Barriot, J.-P.; Lognonné, Ph.

    2005-01-01

    International audience; We present a new procedure to describe the one-dimensional thermodynamical stateand mineralogy of any Earth-like planetary mantle, with Mars as an example. The modelparameters are directly related to expected results from a geophysical network mission, inthis case electromagnetic, geodetic, and seismological processed observationssupplemented with laboratory measurements. We describe the internal structure of theplanet in terms of a one-dimensional model depending on a...

  4. On Comparing Precision Orbit Solutions of Geodetic Satellites Given Several Ocean Tide and Geopotential Models

    Science.gov (United States)

    2014-08-01

    data to calculate precision orbits for several geodetic satellites including LAGEOS-1, LAGEOS-2, STARLETTE and STELLA . By comparing predicted orbits to... STELLA The STELLA satellite was launched in 1993 by CNES, and is virtually identical to the STARLETTE satellite. However, it provides additional coverage...over the polar regions due to its inclination. As with the LAGEOS satellites, both STELLA and STARLETTE are spherically-shaped spacecraft with low

  5. Investigation of post-earthquake displacements in viaducts using Geodetic and Finite Element Methods

    Directory of Open Access Journals (Sweden)

    D. Güney

    2010-12-01

    Full Text Available This paper presents the results of research into the post-earthquake displacements of the partially constructed road viaducts in Bolu, Turkey after the Izmit/Kocaeli, (Mw = 7.4, and Düzce (Mw = 7.1 earthquakes on 17 August and 12 November 1999, respectively. The investigations on the viaducts were carried out using both Geodetic and Finite Element Methods (FEM. Firstly, all the geodetic network stations selected for the project were checked because of the recent deformation in the area. Then, new control stations were placed between the piers of the viaducts. 28 object points were placed and measured on each pier to determine their displacements. In the second stage, the behaviours of the viaducts were modelled using the FEM, and the Düzce earthquake acceleration record was analysed to observe the response of the viaducts in a time history domain. The modelled displacement response of the viaducts was compared with the geodetic measurements in order to interpret the sensitivity of the design calculation of the engineering model. The pier displacements that were geodetically measured and calculated using FEM peak pier displacements showed an increase in the piers located closer to the surface rupture from the Izmit/Kocaeli and Düzce earthquakes. The agreement between the observed and modelled displacements decreases with the increase in the distance from the fault line. Since, near the fault trace the horizontal displacement field is discontinuous and large inelastic deformation is expected, the behaviour of the part of the structure located near the fault line cannot be easily reproduced by FEM simulations. This is because the applied model loads derived from the source acceleration spectra cannot be included in the localized finite deformation effects. In order to obtain an improved engineering analysis, it is necessary to utilise more parameters in the numerical analysis.

  6. Planetary geodetic control using satellite imaging. [equations for determination of control points from surface television-imagery

    Science.gov (United States)

    Duxbury, T. C.

    1979-01-01

    A new data type for planetary geodetic control using natural satellite imaging is presented. Spacecraft images of natural satellites against the planet give a direct tie between inertial space and surface features surrounding the satellite image. This technique is expected to offer a factor of 3-10 improvement in accuracy over present geodetic reduction for Mars. A specific example using Viking imaging of Phobos against Mars is given.

  7. Designing a new Geodetic Research Data Management System for the Hartebeesthoek Radio Astronomy Observatory

    Science.gov (United States)

    Coetzer, Glend Lorraine

    2015-08-01

    The Hartebeesthoek Radio Astronomy Observatory (HartRAO) participates in astronomic, astrometric and geodetic Very Long Baseline Interferometry (VLBI) observations using both 26- and 15-m diameter radio telescopes. Geodetic data from a Satellite Laser Ranger (SLR), Global Navigation Satellite System (GNSS), Met4 weather stations and a new seismic vault network must be stored at HartRAO and made available to the scientific community. Some data are e-transferred to correlators, analysis centres and space geodesy data providers, while some data are processed locally to produce basic data products. The new South African co-located seismology network of seismic and GNSS instrumentation will generate large volumes of raw data to be stored and archived at HartRAO. The current data storage systems are distributed and outdated, and management systems currently being used will also not be able to handle the additional large volumes of data. This necessitates the design and implementation of a new, modern research data management system which combines all the datasets into one database, as well as cater for current and future data volume requirements. The librarian’s expertise and knowledge will be used in the design and implementation of the new HartRAO Geodetic Research Data Management System (GRDMS). The librarian’s role and involvement in the design and implementation of the new GRDMS are presented here. Progress to date will also be discussed.

  8. Extending Resolution of Fault Slip With Geodetic Networks Through Optimal Network Design

    Science.gov (United States)

    Sathiakumar, Sharadha; Barbot, Sylvain Denis; Agram, Piyush

    2017-12-01

    Geodetic networks consisting of high precision and high rate Global Navigation Satellite Systems (GNSS) stations continuously monitor seismically active regions of the world. These networks measure surface displacements and the amount of geodetic strain accumulated in the region and give insight into the seismic potential. SuGar (Sumatra GPS Array) in Sumatra, GEONET (GNSS Earth Observation Network System) in Japan, and PBO (Plate Boundary Observatory) in California are some examples of established networks around the world that are constantly expanding with the addition of new stations to improve the quality of measurements. However, installing new stations to existing networks is tedious and expensive. Therefore, it is important to choose suitable locations for new stations to increase the precision obtained in measuring the geophysical parameters of interest. Here we describe a methodology to design optimal geodetic networks that augment the existing system and use it to investigate seismo-tectonics at convergent and transform boundaries considering land-based and seafloor geodesy. The proposed network design optimization would be pivotal to better understand seismic and tsunami hazards around the world. Land-based and seafloor networks can monitor fault slip around subduction zones with significant resolution, but transform faults are more challenging to monitor due to their near-vertical geometry.

  9. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  10. New Geodetic Results from the Hauraki Rift: Slow Continental Rifting Oblique to Subduction, North Island, New Zealand

    Science.gov (United States)

    Pickle, R. C.; Eccles, J. D.; Hreinsdottir, S.; Palmer, N.; Rowland, J. V.

    2016-12-01

    The Hauraki Rift, an active but slow-deforming narrow intra-continental rift in northern New Zealand paradoxically strikes nearly normal to the Pacific-Australian oblique subduction boundary 300+ km to the southeast. Both the driving mechanism and quantitative details of the rift's current activity are unknown. Past GPS/GNSS geodetic surveying in the area has been coarse and erratic (e.g. single 8-hour surveys in 1995). In 2015 and again in 2016 a 37 station network of existing benchmarks around the rift was measured with the aim of gaining better insight into deformation in the region. We find that it is primarily extensional ( 0.9 mm/yr) with a small portion of right-lateral shearing ( 0.1 mm/yr) relative to a fixed Australian plate in ITRF2008. Closer to the plate boundary, the oblique westward subduction of the Pacific plate generates a strong clockwise angular strain signature in the over-riding plate; this same angular stress field is the simplest explanation for the Hauraki Rift's axis-perpendicular strain and in consistent with previous geophysical observations. Additionally, several short wavelength dislocations between our velocity solutions hint at the existence of undocumented active faults which will have implications to the seismic hazard to Auckland, New Zealand's largest city, located just 50km west of the rift.

  11. A new velocity field for Africa from combined GPS and DORIS space geodetic Solutions: Contribution to the definition of the African reference frame (AFREF)

    Science.gov (United States)

    Saria, E.; Calais, E.; Altamimi, Z.; Willis, P.; Farah, H.

    2013-04-01

    We analyzed 16 years of GPS and 17 years of Doppler orbitography and radiopositioning integrated by satellite (DORIS) data at continuously operating geodetic sites in Africa and surroundings to describe the present-day kinematics of the Nubian and Somalian plates and constrain relative motions across the East African Rift. The resulting velocity field describes horizontal and vertical motion at 133 GPS sites and 9 DORIS sites. Horizontal velocities at sites located on stable Nubia fit a single plate model with a weighted root mean square residual of 0.6 mm/yr (maximum residual 1 mm/yr), an upper bound for plate-wide motions and for regional-scale deformation in the seismically active southern Africa and Cameroon volcanic line. We confirm significant southward motion ( ˜ 1.5 mm/yr) in Morocco with respect to Nubia, consistent with earlier findings. We propose an updated angular velocity for the divergence between Nubia and Somalia, which provides the kinematic boundary conditions to rifting in East Africa. We update a plate motion model for the East African Rift and revise the counterclockwise rotation of the Victoria plate and clockwise rotation of the Rovuma plate with respect to Nubia. Vertical velocities range from - 2 to +2 mm/yr, close to their uncertainties, with no clear geographic pattern. This study provides the first continent-wide position/velocity solution for Africa, expressed in International Terrestrial Reference Frame (ITRF2008), a contribution to the upcoming African Reference Frame (AFREF). Except for a few regions, the African continent remains largely under-sampled by continuous space geodetic data. Efforts are needed to augment the geodetic infrastructure and openly share existing data sets so that the objectives of AFREF can be fully reached.

  12. Rupture history of the 2008 Mw 7.9 Wenchuan, China, earthquake: Evaluation of separate and joint inversions of geodetic, teleseismic, and strong-motion data

    Science.gov (United States)

    Hartzell, Stephen; Mendoza, Carlos; Ramírez-Guzmán, Leonardo; Zeng, Yuesha; Mooney, Walter

    2013-01-01

    An extensive data set of teleseismic and strong-motion waveforms and geodetic offsets is used to study the rupture history of the 2008 Wenchuan, China, earthquake. A linear multiple-time-window approach is used to parameterize the rupture. Because of the complexity of the Wenchuan faulting, three separate planes are used to represent the rupturing surfaces. This earthquake clearly demonstrates the strengths and limitations of geodetic, teleseismic, and strong-motion data sets. Geodetic data (static offsets) are valuable for determining the distribution of shallower slip but are insensitive to deeper faulting and reveal nothing about the timing of slip. Teleseismic data in the distance range 30°–90° generally involve no modeling difficulties because of simple ray paths and can distinguish shallow from deep slip. Teleseismic data, however, cannot distinguish between different slip scenarios when multiple fault planes are involved because steep takeoff angles lead to ambiguity in timing. Local strong-motion data, on the other hand, are ideal for determining the direction of rupture from directivity but can easily be over modeled with inaccurate Green’s functions, leading to misinterpretation of the slip distribution. We show that all three data sets are required to give an accurate description of the Wenchuan rupture. The moment is estimated to be approximately 1.0 × 1021 N · m with the slip characterized by multiple large patches with slips up to 10 m. Rupture initiates on the southern end of the Pengguan fault and proceeds unilaterally to the northeast. Upon reaching the cross-cutting Xiaoyudong fault, rupture of the adjacent Beichuan fault starts at this juncture and proceeds bilaterally to the northeast and southwest.

  13. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  14. GBIS (Geodetic Bayesian Inversion Software): Rapid Inversion of InSAR and GNSS Data to Estimate Surface Deformation Source Parameters and Uncertainties

    Science.gov (United States)

    Bagnardi, M.; Hooper, A. J.

    2017-12-01

    Inversions of geodetic observational data, such as Interferometric Synthetic Aperture Radar (InSAR) and Global Navigation Satellite System (GNSS) measurements, are often performed to obtain information about the source of surface displacements. Inverse problem theory has been applied to study magmatic processes, the earthquake cycle, and other phenomena that cause deformation of the Earth's interior and of its surface. Together with increasing improvements in data resolution, both spatial and temporal, new satellite missions (e.g., European Commission's Sentinel-1 satellites) are providing the unprecedented opportunity to access space-geodetic data within hours from their acquisition. To truly take advantage of these opportunities we must become able to interpret geodetic data in a rapid and robust manner. Here we present the open-source Geodetic Bayesian Inversion Software (GBIS; available for download at http://comet.nerc.ac.uk/gbis). GBIS is written in Matlab and offers a series of user-friendly and interactive pre- and post-processing tools. For example, an interactive function has been developed to estimate the characteristics of noise in InSAR data by calculating the experimental semi-variogram. The inversion software uses a Markov-chain Monte Carlo algorithm, incorporating the Metropolis-Hastings algorithm with adaptive step size, to efficiently sample the posterior probability distribution of the different source parameters. The probabilistic Bayesian approach allows the user to retrieve estimates of the optimal (best-fitting) deformation source parameters together with the associated uncertainties produced by errors in the data (and by scaling, errors in the model). The current version of GBIS (V1.0) includes fast analytical forward models for magmatic sources of different geometry (e.g., point source, finite spherical source, prolate spheroid source, penny-shaped sill-like source, and dipping-dike with uniform opening) and for dipping faults with uniform

  15. Seismically and Geodetically Constrained Source Mechanisms of Volcanic Induced Seismicity - Miyakejima, Japan, 2000

    Science.gov (United States)

    Minson, S. E.; Dreger, D. S.; Burgmann, R.

    2003-12-01

    During a period of volcanic unrest on Miyakejima, Japan in 2000, the largest recorded earthquake swarm in Japan occurred (Japan Meteorological Agency (JMA), 2000). More than 100,000 earthquakes were recorded in the next two months (Ito and Yoshioka, 2002). But the most notable feature of this seismicity is that it migrated northwest with an offshore dike intrusion. In this study, seismic and GPS data are used to independently determine source mechanisms for the two largest earthquakes in this sequence. Broadband seismic data from stations operated by the F-net Broadband Seismograph Network were used in linear moment tensor inversions (Dreger et al, 2000; Dreger and Woods, 2002) to determine deviatoric and full moment tensor mechanisms. Nonlinear inversions of GPS data (Bürgmann et al., 1997) recorded at stations operated by the Geographical Survey Institute of Japan (GSI) were used to find the geometry and slip distribution for each event. Seismic data alone was used to invert for the mechanisms of an additional sixteen earthquakes. Of the eighteen events studied, three have particularly significant mechanisms: EVT3, EVT7, and EVT15. EVT7 occurred on July 8, the same day as the first summit eruption and the formation of a caldera on Miyakejima. The source mechanism for EVT7 has a large volumetric component and appears to be directly related to these processes. For EVT15, the source mechanism from the moment tensor inversions is that of a north-south orientated strike-slip earthquake, making it one of the few double-couple earthquakes in this sequence. The GPS data for EVT15 independently predict a mechanism that is very similar to the mechanism determined by the moment tensor inversions. Furthermore, synthetic seismograms generated using the mechanism determined by the GPS inversions fit the observed seismograms extremely well. This is particularly noteworthy because it shows that the GPS data can predict a completely independent data set. When EVT3 (a large

  16. Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer.

    Science.gov (United States)

    Bendell, Johanna C; Ervin, Thomas J; Gallinson, David; Singh, Jaswinder; Wallace, James A; Saleh, Mansoor N; Vallone, Marcy; Phan, See-Chun; Hack, Stephen P

    2013-09-01

    Dysregulation of the hepatocyte growth factor (HGF)/MET pathway is associated with poor prognosis, more aggressive biological characteristics of the tumor, and shortened survival in patients with metastatic colorectal cancer (mCRC). Onartuzumab (MetMAb) is a recombinant humanized monovalent monoclonal antibody directed against MET. We present the treatment rationale and protocol for an ongoing randomized multicenter placebo-controlled phase II study designed to evaluate the efficacy and safety of MetMAb combined with bevacizumab and mFOLFOX-6 (5-fluoruracil, leucovorin, and oxaliplatin). Eligible patients with previously untreated mCRC are randomized 1:1 to either mFOLFOX-6 combined with bevacizumab and placebo followed by 5-fluorouracil/leucovorin plus bevacizumab and placebo or mFOLFOX6, bevacizumab plus MetMAb followed by 5 FU/LV, bevacizumab, and MetMAb. The primary end point of this study is progression-free survival (PFS) in the intent-to-treat (ITT) population. Secondary end points include overall survival (OS), objective response rate, and safety. Subanalyses will be performed to evaluate the effect of MET receptor expression on study primary and secondary end points. Correlative studies will be performed on tissue- and blood-derived biomarkers related to both HGF/MET signaling and other associated pathway markers. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Seismic hazard assessment of Sub-Saharan Africa using geodetic strain rate models

    Science.gov (United States)

    Poggi, Valerio; Pagani, Marco; Weatherill, Graeme; Garcia, Julio; Durrheim, Raymond J.; Mavonga Tuluka, Georges

    2016-04-01

    The East African Rift System (EARS) is the major active tectonic feature of the Sub-Saharan Africa (SSA) region. Although the seismicity level of such a divergent plate boundary can be described as moderate, several earthquakes have been reported in historical times causing a non-negligible level of damage, albeit mostly due to the high vulnerability of the local buildings and structures. Formulation and enforcement of national seismic codes is therefore an essential future risk mitigation strategy. Nonetheless, a reliable risk assessment cannot be done without the calibration of an updated seismic hazard model for the region. Unfortunately, the major issue in assessing seismic hazard in Sub-Saharan Africa is the lack of basic information needed to construct source and ground motion models. The historical earthquake record is largely incomplete, while instrumental catalogue is complete down to sufficient magnitude only for a relatively short time span. In addition, mapping of seimogenically active faults is still an on-going program. Recent studies have identified major seismogenic lineaments, but there is substantial lack of kinematic information for intermediate-to-small scale tectonic features, information that is essential for the proper calibration of earthquake recurrence models. To compensate this lack of information, we experiment the use of a strain rate model recently developed by Stamps et al. (2015) in the framework of a earthquake hazard and risk project along the EARS supported by USAID and jointly carried out by GEM and AfricaArray. We use the inferred geodetic strain rates to derive estimates of total scalar moment release, subsequently used to constrain earthquake recurrence relationships for both area (as distributed seismicity) and fault source models. The rates obtained indirectly from strain rates and more classically derived from the available seismic catalogues are then compared and combined into a unique mixed earthquake recurrence model

  18. Combination of terrestrial reference frames based on space geodetic techniques in SHAO: methodology and main issues

    Science.gov (United States)

    He, Bing; Wang, Xiao-Ya; Hu, Xiao-Gong; Zhao, Qun-He

    2017-09-01

    Based on years of input from the four geodetic techniques (SLR, GPS, VLBI and DORIS), the strategies of the combination were studied in SHAO to generate a new global terrestrial reference frame as the material realization of the ITRS defined in IERS Conventions. The main input includes the time series of weekly solutions (or fortnightly for SLR 1983-1993) of observational data for satellite techniques and session-wise normal equations for VLBI. The set of estimated unknowns includes 3-dimensional Cartesian coordinates at the reference epoch 2005.0 of the stations distributed globally and their rates as well as the time series of consistent Earth Orientation Parameters (EOPs) at the same epochs as the input. Besides the final solution, namely SOL-2, generated by using all the inputs before 2015.0 obtained from short-term observation processing, another reference solution, namely SOL-1, was also computed by using the input before 2009.0 based on the same combination of procedures for the purpose of comparison with ITRF2008 and DTRF2008 and for evaluating the effect of the latest six more years of data on the combined results. The estimated accuracy of the x-component and y-component of the SOL-1 TRF-origin was better than 0.1 mm at epoch 2005.0 and better than 0.3 mm yr-1 in time evolution, either compared with ITRF2008 or DTRF2008. However, the z-component of the translation parameters from SOL-1 to ITRF2008 and DTRF2008 were 3.4 mm and -1.0 mm, respectively. It seems that the z-component of the SOL-1 TRF-origin was much closer to the one in DTRF2008 than the one in ITRF2008. The translation parameters from SOL-2 to ITRF2014 were 2.2, -1.8 and 0.9 mm in the x-, y- and z-components respectively with rates smaller than 0.4 mm yr-1. Similarly, the scale factor transformed from SOL-1 to DTRF2008 was much smaller than that to ITRF2008. The scale parameter from SOL-2 to ITRF2014 was -0.31 ppb with a rate lower than 0.01 ppb yr-1. The external precision (WRMS) compared

  19. 4-D Visualization of Seismic and Geodetic Data of the Big Island of Hawai'i

    Science.gov (United States)

    Burstein, J. A.; Smith-Konter, B. R.; Aryal, A.

    2017-12-01

    For decades Hawai'i has served as a natural laboratory for studying complex interactions between magmatic and seismic processes. Investigating characteristics of these processes, as well as the crustal response to major Hawaiian earthquakes, requires a synthesis of seismic and geodetic data and models. Here, we present a 4-D visualization of the Big Island of Hawai'i that investigates geospatial and temporal relationships of seismicity, seismic velocity structure, and GPS crustal motions to known volcanic and seismically active features. Using the QPS Fledermaus visualization package, we compile 90 m resolution topographic data from NASA's Shuttle Radar Topography Mission (SRTM) and 50 m resolution bathymetric data from the Hawaiian Mapping Research Group (HMRG) with a high-precision earthquake catalog of more than 130,000 events from 1992-2009 [Matoza et al., 2013] and a 3-D seismic velocity model of Hawai'i [Lin et al., 2014] based on seismic data from the Hawaiian Volcano Observatory (HVO). Long-term crustal motion vectors are integrated into the visualization from HVO GPS time-series data. These interactive data sets reveal well-defined seismic structure near the summit areas of Mauna Loa and Kilauea volcanoes, where high Vp and high Vp/Vs anomalies at 5-12 km depth, as well as clusters of low magnitude (M seismicity, are observed. These areas of high Vp and high Vp/Vs are interpreted as mafic dike complexes and the surrounding seismic clusters are associated with shallow magma processes. GPS data are also used to help identify seismic clusters associated with the steady crustal detachment of the south flank of Kilauea's East Rift Zone. We also investigate the fault geometry of the 2006 M6.7 Kiholo Bay earthquake event by analyzing elastic dislocation deformation modeling results [Okada, 1985] and HVO GPS and seismic data of this event. We demonstrate the 3-D fault mechanisms of the Kiholo Bay main shock as a combination of strike-slip and dip-slip components

  20. The impact of model prediction error in designing geodetic networks for crustal deformation applications

    Science.gov (United States)

    Murray, J. R.

    2017-12-01

    Earth surface displacements measured at Global Navigation Satellite System (GNSS) sites record crustal deformation due, for example, to slip on faults underground. A primary objective in designing geodetic networks to study crustal deformation is to maximize the ability to recover parameters of interest like fault slip. Given Green's functions (GFs) relating observed displacement to motion on buried dislocations representing a fault, one can use various methods to estimate spatially variable slip. However, assumptions embodied in the GFs, e.g., use of a simplified elastic structure, introduce spatially correlated model prediction errors (MPE) not reflected in measurement uncertainties (Duputel et al., 2014). In theory, selection algorithms should incorporate inter-site correlations to identify measurement locations that give unique information. I assess the impact of MPE on site selection by expanding existing methods (Klein et al., 2017; Reeves and Zhe, 1999) to incorporate this effect. Reeves and Zhe's algorithm sequentially adds or removes a predetermined number of data according to a criterion that minimizes the sum of squared errors (SSE) on parameter estimates. Adapting this method to GNSS network design, Klein et al. select new sites that maximize model resolution, using trade-off curves to determine when additional resolution gain is small. Their analysis uses uncorrelated data errors and GFs for a uniform elastic half space. I compare results using GFs for spatially variable strike slip on a discretized dislocation in a uniform elastic half space, a layered elastic half space, and a layered half space with inclusion of MPE. I define an objective criterion to terminate the algorithm once the next site removal would increase SSE more than the expected incremental SSE increase if all sites had equal impact. Using a grid of candidate sites with 8 km spacing, I find the relative value of the selected sites (defined by the percent increase in SSE that further

  1. Concomitant and previous osteoporotic vertebral fractures.

    Science.gov (United States)

    Lenski, Markus; Büser, Natalie; Scherer, Michael

    2017-04-01

    Background and purpose - Patients with osteoporosis who present with an acute onset of back pain often have multiple fractures on plain radiographs. Differentiation of an acute osteoporotic vertebral fracture (AOVF) from previous fractures is difficult. The aim of this study was to investigate the incidence of concomitant AOVFs and previous OVFs in patients with symptomatic AOVFs, and to identify risk factors for concomitant AOVFs. Patients and methods - This was a prospective epidemiological study based on the Registry of Pathological Osteoporotic Vertebral Fractures (REPAPORA) with 1,005 patients and 2,874 osteoporotic vertebral fractures, which has been running since February 1, 2006. Concomitant fractures are defined as at least 2 acute short-tau inversion recovery (STIR-) positive vertebral fractures that happen concomitantly. A previous fracture is a STIR-negative fracture at the time of initial diagnostics. Logistic regression was used to examine the influence of various variables on the incidence of concomitant fractures. Results - More than 99% of osteoporotic vertebral fractures occurred in the thoracic and lumbar spine. The incidence of concomitant fractures at the time of first patient contact was 26% and that of previous fractures was 60%. The odds ratio (OR) for concomitant fractures decreased with a higher number of previous fractures (OR =0.86; p = 0.03) and higher dual-energy X-ray absorptiometry T-score (OR =0.72; p = 0.003). Interpretation - Concomitant and previous osteoporotic vertebral fractures are common. Risk factors for concomitant fractures are a low T-score and a low number of previous vertebral fractures in cases of osteoporotic vertebral fracture. An MRI scan of the the complete thoracic and lumbar spine with STIR sequence reduces the risk of under-diagnosis and under-treatment.

  2. Uterine rupture without previous caesarean delivery

    DEFF Research Database (Denmark)

    Thisted, Dorthe L. A.; H. Mortensen, Laust; Krebs, Lone

    2015-01-01

    OBJECTIVE: To determine incidence and patient characteristics of women with uterine rupture during singleton births at term without a previous caesarean delivery. STUDY DESIGN: Population based cohort study. Women with term singleton birth, no record of previous caesarean delivery and planned...... vaginal delivery (n=611,803) were identified in the Danish Medical Birth Registry (1997-2008). Medical records from women recorded with uterine rupture during labour were reviewed to ascertain events of complete uterine rupture. Relative Risk (RR) and adjusted Relative Risk Ratio (aRR) of complete uterine...... rupture with 95% confidence intervals (95% CI) were ascertained according to characteristics of the women and of the delivery. RESULTS: We identified 20 cases with complete uterine rupture. The incidence of complete uterine rupture among women without previous caesarean delivery was about 3...

  3. Integration Of GPS And GLONASS Systems In Geodetic Satellite Measurements

    Science.gov (United States)

    Maciuk, Kamil

    2015-12-01

    The article shows the results of satellites measurements elaborations using GPS & GLONASS signals. The aim of this article is to define the influence of adding GLONASS signals on position determination accuracy. It especially concerns areas with big horizon coverages. Object of the study were analysis of DOP coefficients, code and RTK solutions, and usage of satellite techniques in levelling. The performed studies and analysis show that integrated GPS-GLONASS satellite measurements provide possibility to achieve better results than measurements using single navigation satellite system (GPS).

  4. The predictive effect of fear-avoidance beliefs on low back pain among newly qualified health care workers with and without previous low back pain: a prospective cohort study

    DEFF Research Database (Denmark)

    Jensen, Jette Nygaard; Albertsen, Karen; Borg, Vilhelm

    2009-01-01

    and maintenance of LBP. Accordingly, the main objective of this study was to examine (1) the association between physical work load and LBP, (2) the predictive effect of fear-avoidance beliefs on the development of LBP, and (3) the moderating effect of fear-avoidance beliefs on the association between physical...... work load and LBP among cases with and without previous LBP....

  5. Coral microatoll as geodetic tool in North Andaman and Little ...

    Indian Academy of Sciences (India)

    as a proxy for a level line and this level line has a known elevation with respect to the sea level. From the study of coral microatolls at North Reef and. Interview islands on the western coast of Andaman,. Kayanne et al (2007) have estimated 1.3m ver- tical uplift in that part. Rajendran et al (2007) have shown the microatolls ...

  6. Geodetic Imaging of Marsh Surface Elevation with Terrestrial Laser Scanning

    Science.gov (United States)

    Nguyen, C. T.; Starek, M. J.; Gibeaut, J. C.; Lord, A.

    2015-12-01

    The resilience of marshes to a rising sea is dependent on their elevation response. Given the level of precision required to measure minute changes in marsh elevation over time, survey methods have to be adapted to minimize impacts to the sediment surface. Current approaches include Surface Elevation Tables (SETs), which are used to monitor wetland surface change with respect to an in situ vertical benchmark. Although SETs have been proven as an effective technique to track subtle sedimentation rates (RTK GPS for comparison. Grand Bay in Mississippi USA is one of the most biologically productive estuarine ecosystems in the Gulf of Mexico. The study region is covered by dense and tall saw-grass that makes it a challenging environment for bare-earth mapping. For this survey, a Riegl VZ-400 TLS (1550 nm wavelength) was utilized. The system is capable of recording multiple returns per a transmitted pulse (up to 15) and provides full-waveform output for signal post-processing to extract returns. The objectives of the study are twofold: 1) examine impacts of TLS survey design, scan angle and scan density on marsh elevation mapping; 2) assess the capabilities of multiple-echo and full-waveform TLS data to extract the bare-earth surface below the dense vegetation. This presentation will present results of the study including the developed TLS survey protocol and data processing workflow, details on waveform and multi-echo approaches for ground point detection, and a discussion on error analysis and challenges for measuring marsh surface elevation with TLS.

  7. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    pregnancy if they were married, educated, had dental insurance, previously used dental services when not pregnant, or had knowledge about the possible connection between oral health and pregnancy outcome8. The purpose of this study was to explore the factors determining good oral hygiene among pregnant women ...

  8. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    The perceptions of educational manag ers from previously disadvantaged primary and high schools in the Nelson Mandela Metropole regarding the issue of empowerment are outlined and the perceptions of educational managers in terms of various aspects of empowerment at different levels reflected. A literature study ...

  9. Laboratory Grouping Based on Previous Courses.

    Science.gov (United States)

    Doemling, Donald B.; Bowman, Douglas C.

    1981-01-01

    In a five-year study, second-year human physiology students were grouped for laboratory according to previous physiology and laboratory experience. No significant differences in course or board examination performance were found, though correlations were found between predental grade-point averages and grouping. (MSE)

  10. Volcano-tectonic deformation in the Kivu Region, Central Africa: Results from six years of continuous GNSS observations of the Kivu Geodetic Network (KivuGNet)

    Science.gov (United States)

    Geirsson, Halldor; d'Oreye, Nicolas; Mashagiro, Niche; Syauswa, Muhindo; Celli, Gilles; Kadufu, Benjamin; Smets, Benoît; Kervyn, François

    2017-10-01

    We present an overview of the installation, operation, and initial results of the 15-station KivuGNet (Kivu Geodetic Network) in the Kivu Region, Central Africa. The network serves primarily as a research and monitoring tool for active volcanic, earthquake, and plate boundary processes in the region. Continuous operation of in-situ measurement networks in naturally and politically harsh environments is challenging, but has proven fruitful in this case. During the operation of the network since 2009, KivuGNet has captured: co-eruptive deformation from two eruptions of Nyamulagira (in 2010 and 2011-2012); inter-eruptive deformation, which we interpret as a combination of plate motion across the Western - East Africa Rift, and decreasing deep-seated magma accumulation under the Nyiragongo-Nyamulagira region; co-seismic deformation from the Mw5.8 August 7, 2015 Lwiro earthquake at the western border of Lake Kivu. We hope that this study will serve as a motivation for further implementation of in-situ geodetic networks in under-monitored and under-studied sections of the East African Rift.

  11. Combination of coseismic displacement fields: a geodetic perspective

    Directory of Open Access Journals (Sweden)

    Roberto Devoti

    2012-10-01

    Full Text Available This study provides the mathematical framework for the rigorous combination of coseismic offsets observed by a global positioning system (GPS network and investigates the results obtained on the occasion of the recent Emilia earthquakes (Italy. This seismic sequence that affected northern Italy from May 20, 2012, allowed two offset fields to be computed, one with reference to the mainshock (M 5.9, followed by two other M 5.1 events on the same day, and a second with reference to the replicas that occurred on May 29, 2012 (M 5.8, M 5.3 and M 5.2; ISIDe data archive, http://iside.rm.ingv.it. The final displacement field is basically the result of a comparison and validation process with repeated feedback between the different analysis groups at the Istituto Nazionale di Geofisica e Vulcanologia (INGV; National Institute of Geophysics and Volcanology that was established to obtain prompt coseismic displacement solutions, as precise as possible, and in the first days after an event. This is important for early seismic-source evaluation as it represents the most complete and validated dataset at the very early stage of a seismic crisis, and it is also extremely useful in reducing random and systematic errors in the estimated parameters. This study is the result of a cooperative effort that involved different research groups at INGV, with the sharing of all of the collected GPS data. The intention was to compare these results and thus reducing sources of error associated with individual processing strategies, to allow the final combination of the different displacement fields into a single consensus solution. The process assessed the robustness of each single GPS result, thus minimizing erroneous interpretations of individual solutions. […

  12. Birth after caesarean study – planned vaginal birth or planned elective repeat caesarean for women at term with a single previous caesarean birth: protocol for a patient preference study and randomised trial

    Directory of Open Access Journals (Sweden)

    Haslam Ross R

    2007-08-01

    Full Text Available Abstract Background For women who have a caesarean section in their preceding pregnancy, two care policies for birth are considered standard: planned vaginal birth and planned elective repeat caesarean. Currently available information about the benefits and harms of both forms of care are derived from retrospective and prospective cohort studies. There have been no randomised trials, and recognising the deficiencies in the literature, there have been calls for methodologically rigorous studies to assess maternal and infant health outcomes associated with both care policies. The aims of our study are to assess in women with a previous caesarean birth, who are eligible in the subsequent pregnancy for a vaginal birth, whether a policy of planned vaginal birth after caesarean compared with a policy of planned repeat caesarean affects the risk of serious complications for the woman and her infant. Methods/Design Design: Multicentred patient preference study and a randomised clinical trial. Inclusion Criteria: Women with a single prior caesarean presenting in their next pregnancy with a single, live fetus in cephalic presentation, who have reached 37 weeks gestation, and who do not have a contraindication to a planned VBAC. Trial Entry & Randomisation: Eligible women will be given an information sheet during pregnancy, and will be recruited to the study from 37 weeks gestation after an obstetrician has confirmed eligibility for a planned vaginal birth. Written informed consent will be obtained. Women who consent to the patient preference study will be allocated their preference for either planned VBAC or planned, elective repeat caesarean. Women who consent to the randomised trial will be randomly allocated to either the planned vaginal birth after caesarean or planned elective repeat caesarean group. Treatment Groups: Women in the planned vaginal birth group will await spontaneous onset of labour whilst appropriate. Women in the elective repeat

  13. G-larmS: An Infrastructure for Geodetic Earthquake Early Warning, applied to Northern California

    Science.gov (United States)

    Johanson, I. A.; Grapenthin, R.; Allen, R. M.

    2014-12-01

    Integrating geodetic data into seismic earthquake early warning (EEW) is critical for accurately resolving magnitude and finite fault dimensions in the very largest earthquakes (M>7). We have developed G-larmS, the Geodetic alarm System, as part of our efforts to incorporate geodetic data into EEW for Northern California. G-larmS is an extensible geodetic EEW infrastructure that analyzes positioning time series from real-time GPS processors, such as TrackRT or RTNET. It is currently running in an operational mode at the Berkeley Seismological Laboratory (BSL) where we use TrackRT to produce high sample rate displacement time series for 62 GPS stations in the greater San Francisco Bay Area with 3-4 second latency. We employ a fully triangulated network scheme, which provides resiliency against an outage or telemetry loss at any individual station, for a total of 165 basestation-rover pairs. G-larmS is tightly integrated into seismic alarm systems (CISN ShakeAlert, ElarmS) as it uses their P-wave detection alarms to trigger its own processing and sends warning messages back to the ShakeAlert decision module. Once triggered, G-larmS estimates the static offset at each station pair and inputs these into an inversion for fault slip, which is updated once per second. The software architecture and clear interface definitions of this Python implementation enable straightforward extensibility and exchange of specific algorithms that operate in the individual modules. For example, multiple modeling instances can be called in parallel, each of which applying a different strategy to infer fault and magnitude information (e.g., pre-defined fault planes, full grid search, least squares inversion, etc.). This design enables, for example, quick tests, expansion and algorithm comparisons. Here, we present the setup and report results of the first months of operation in Northern California. This includes analysis of system latencies, noise, and G-larmS' response to actual events. We

  14. Introduction to GPS geodetic infrastructure for land subsidence monitoring in Houston, Texas, USA

    Directory of Open Access Journals (Sweden)

    G. Wang

    2015-11-01

    Full Text Available Houston, Texas is one of the places that first employed high-accuracy GPS technology for land subsidence monitoring beginning in the late 1980s. Currently, there are over 170 permanent GPS stations located in the Houston metropolitan area. This article summarizes the current GPS geodetic infrastructure in the Houston metropolitan area, which is comprised of three components: a dense GPS network with 170 permanent stations, a stable Houston reference frame (SHRF14, and sophisticated software packages for post positioning processing. Average land subsidence and groundwater-level altitude changes during the past 10 years (2005–2014 also are presented in this paper.

  15. Reappraisal of the 2010 Maule, 2014 Iquique, 2015 Illapel through Inversion of Geodetic Data and Tsunami Waveforms Using the Optimal Time Alignment (OTA) Method

    Science.gov (United States)

    Romano, F.; Lorito, S.; Piatanesi, A.; Volpe, M.; Lay, T.; Tolomei, C.; Murphy, S.; Tonini, R.; Escalante, C.; Castro, M. J.; Gonzalez-Vida, J. M.; Macias, J.

    2017-12-01

    The Chile subduction zone is one of the most seismically active regions in the world and it hosted a number of great tsunamigenic earthquakes in the past. In particular, during the last 7 years three M8+ earthquakes occurred nearby the Chilean coasts, that is the 2010 M8.8 Maule, the 2014 M8.1 Iquique, and the M8.3 2015 Illapel earthquakes. The rupture process of these earthquakes has been studied by using different kind of geophysical observations such as seismic, geodetic, and tsunami data; in particular, tsunami waveforms are important for constraining the slip on the offshore portion of the fault. However, it has been shown that forward modelling of tsunami data can be affected by unavailability of accurate bathymetric models, especially in the vicinity of the tide-gauges; and in the far field by water density gradients, ocean floor elasticity, or geopotential gravity changes, generally neglected. This could result in a mismatch between observed and predicted tsunami signals thus affecting the retrieved tsunami source image. Recently, a method has been proposed for automatic correction during the nonlinear inversion of the mismatch (optimal time alignment, OTA; Romano et al., GRL, 2016). Here, we present a reappraisal of the joint inversion of tsunami data with OTA procedure and geodetic data, for the Maule, Iquique, and Illapel earthquakes. We compare the results with those obtained by tsunami inversion without using OTA and with other published inversion results.

  16. Geodetic slip solutions for the Mw = 7.4 Champerico (Guatemala) earthquake of 2012 November 7 and its postseismic deformation

    Science.gov (United States)

    Ellis, Andria P.; DeMets, Charles; Briole, Pierre; Molina, Enrique; Flores, Omar; Rivera, Jeffrey; Lasserre, Cécile; Lyon-Caen, Hélène; Lord, Neal

    2015-05-01

    As the first large subduction thrust earthquake off the coast of western Guatemala in the past several decades, the 2012 November 7 Mw = 7.4 earthquake offers the first opportunity to study coseismic and postseismic behaviour along a segment of the Middle America trench where frictional coupling makes a transition from weak coupling off the coast of El Salvador to strong coupling in southern Mexico. We use measurements at 19 continuous GPS sites in Guatemala, El Salvador and Mexico to estimate the coseismic slip and postseismic deformation of the November 2012 Champerico (Guatemala) earthquake. An inversion of the coseismic offsets, which range up to ˜47 mm at the surface near the epicentre, indicates that up to ˜2 m of coseismic slip occurred on a ˜30 × 30 km rupture area between ˜10 and 30 km depth, which is near the global CMT centroid. The geodetic moment of 13 × 1019 N m and corresponding magnitude of 7.4 both agree well with independent seismological estimates. Transient postseismic deformation that was recorded at 11 GPS sites is attributable to a combination of fault afterslip and viscoelastic flow in the lower crust and/or mantle. Modelling of the viscoelastic deformation suggests that it constituted no more than ˜30 per cent of the short-term postseismic deformation. GPS observations that extend six months after the earthquake are well fit by a model in which most afterslip occurred at the same depth or directly downdip from the rupture zone and released energy equivalent to no more than ˜20 per cent of the coseismic moment. An independent seismological slip solution that features more highly concentrated coseismic slip than our own fits the GPS offsets well if its slip centroid is translated ˜50 km to the west to a position close to our slip centroid. The geodetic and seismologic slip solutions thus suggest bounds of 2-7 m for the peak slip along a region of the interface no larger than 30 × 30 km.

  17. Treatment Rationale and Design for J-AXEL: A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.

    Science.gov (United States)

    Yoneshima, Yasuto; Morita, Satoshi; Ando, Masahiko; Miura, Satoru; Yoshioka, Hiroshige; Abe, Tetsuya; Kato, Terufumi; Kondo, Masashi; Hosomi, Yukio; Hotta, Katsuyuki; Yamamoto, Nobuyuki; Kishimoto, Junji; Nakanishi, Yoichi; Okamoto, Isamu

    2017-01-01

    Nanoparticle albumin-bound (nab) paclitaxel is a promising new therapeutic agent for all histologic types of non-small-cell lung cancer (NSCLC). We recently performed a phase 2 study of weekly nab-paclitaxel in patients with previously treated advanced NSCLC, finding promising activity and acceptable toxicity for this regimen. We have now designed a randomized phase 3 intergroup study (J-AXEL, UMIN000017487) to examine the clinical benefit and safety of nab-paclitaxel compared to docetaxel in patients with previously treated advanced NSCLC. Patients are randomized to receive either docetaxel (60 mg/m 2 on day 1 every 3 weeks, control arm) or nab-paclitaxel (100 mg/m 2 on days 1, 8, and 15 every 3 weeks, experimental arm), with each drug being administered until disease progression or unacceptable toxicity. The study will evaluate the noninferiority of nab-paclitaxel relative to docetaxel for the primary end point of overall survival. If the primary objective is achieved, this study will provide evidence for a new alternative treatment option for patients with previously treated advanced NSCLC. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Application of Geodetic Techniques for Antenna Positioning in a Ground Penetrating Radar Method

    Science.gov (United States)

    Mazurkiewicz, Ewelina; Ortyl, Łukasz; Karczewski, Jerzy

    2018-03-01

    The accuracy of determining the location of detectable subsurface objects is related to the accuracy of the position of georadar traces in a given profile, which in turn depends on the precise assessment of the distance covered by an antenna. During georadar measurements the distance covered by an antenna can be determined with a variety of methods. Recording traces at fixed time intervals is the simplest of them. A method which allows for more precise location of georadar traces is recording them at fixed distance intervals, which can be performed with the use of distance triggers (such as a measuring wheel or a hip chain). The search for methods eliminating these discrepancies can be based on the measurement of spatial coordinates of georadar traces conducted with the use of modern geodetic techniques for 3-D location. These techniques include above all a GNSS satellite system and electronic tachymeters. Application of the above mentioned methods increases the accuracy of space location of georadar traces. The article presents the results of georadar measurements performed with the use of geodetic techniques in the test area of Mydlniki in Krakow. A satellite receiver Leica system 1200 and a electronic tachymeter Leica 1102 TCRA were integrated with the georadar equipment. The accuracy of locating chosen subsurface structures was compared.

  19. Uncertainty assessment in geodetic network adjustment by combining GUM and Monte-Carlo-simulations

    Science.gov (United States)

    Niemeier, Wolfgang; Tengen, Dieter

    2017-06-01

    In this article first ideas are presented to extend the classical concept of geodetic network adjustment by introducing a new method for uncertainty assessment as two-step analysis. In the first step the raw data and possible influencing factors are analyzed using uncertainty modeling according to GUM (Guidelines to the Expression of Uncertainty in Measurements). This approach is well established in metrology, but rarely adapted within Geodesy. The second step consists of Monte-Carlo-Simulations (MC-simulations) for the complete processing chain from raw input data and pre-processing to adjustment computations and quality assessment. To perform these simulations, possible realizations of raw data and the influencing factors are generated, using probability distributions for all variables and the established concept of pseudo-random number generators. Final result is a point cloud which represents the uncertainty of the estimated coordinates; a confidence region can be assigned to these point clouds, as well. This concept may replace the common concept of variance propagation and the quality assessment of adjustment parameters by using their covariance matrix. It allows a new way for uncertainty assessment in accordance with the GUM concept for uncertainty modelling and propagation. As practical example the local tie network in "Metsähovi Fundamental Station", Finland is used, where classical geodetic observations are combined with GNSS data.

  20. Facilitating open global data use in earthquake source modelling to improve geodetic and seismological approaches

    Science.gov (United States)

    Sudhaus, Henriette; Heimann, Sebastian; Steinberg, Andreas; Isken, Marius; Vasyura-Bathke, Hannes

    2017-04-01

    In the last few years impressive achievements have been made in improving inferences about earthquake sources by using InSAR (Interferometric Synthetic Aperture Radar) data. Several factors aided these developments. The open data basis of earthquake observations has expanded vastly with the two powerful Sentinel-1 SAR sensors up in space. Increasing computer power allows processing of large data sets for more detailed source models. Moreover, data inversion approaches for earthquake source inferences are becoming more advanced. By now data error propagation is widely implemented and the estimation of model uncertainties is a regular feature of reported optimum earthquake source models. Also, more regularly InSAR-derived surface displacements and seismological waveforms are combined, which requires finite rupture models instead of point-source approximations and layered medium models instead of homogeneous half-spaces. In other words the disciplinary differences in geodetic and seismological earthquake source modelling shrink towards common source-medium descriptions and a source near-field/far-field data point of view. We explore and facilitate the combination of InSAR-derived near-field static surface displacement maps and dynamic far-field seismological waveform data for global earthquake source inferences. We join in the community efforts with the particular goal to improve crustal earthquake source inferences in generally not well instrumented areas, where often only the global backbone observations of earthquakes are available provided by seismological broadband sensor networks and, since recently, by Sentinel-1 SAR acquisitions. We present our work on modelling standards for the combination of static and dynamic surface displacements in the source's near-field and far-field, e.g. on data and prediction error estimations as well as model uncertainty estimation. Rectangular dislocations and moment-tensor point sources are exchanged by simple planar finite

  1. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    International Nuclear Information System (INIS)

    Saitoh, Jun-Ichi; Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro; Sakai, Hiroshi; Kurimoto, Futoshi; Kato, Shingo; Shibuya, Kei

    2012-01-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m 2 , and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade ≥3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade ≥3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  2. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    Energy Technology Data Exchange (ETDEWEB)

    Saitoh, Jun-Ichi, E-mail: junsaito@sannet.ne.jp [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Sakai, Hiroshi; Kurimoto, Futoshi [Division of Respiratory Disease, Saitama Cancer Center, Saitama (Japan); Kato, Shingo [Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Shibuya, Kei [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma (Japan)

    2012-04-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m{sup 2}, and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade {>=}3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade {>=}3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  3. GPS/acoustic Seafloor Geodetic Observations Near the Nankai Trough Axis

    Science.gov (United States)

    Tadokoro, K.; Yasuda, K.; Fujii, C.; Watanabe, T.; Nagai, S.

    2013-12-01

    The GPS/acoustic seafloor geodetic observation system, which uses precise acoustic ranging and kinematic GPS positioning techniques, has been developed as a useful tool for observing seafloor crustal deformations associated with plate convergence and with earthquakes that occurred in ocean area including the 2011 Tohoku-oki Earthquake of Mw 9.0. Our research group installed eight seafloor benchmarks for this observation system in source areas of anticipated major interplate earthquakes along the Nankai Trough, off southwestern Japan. We have performed campaign measurement for 4-8 years until the end of 2012. The error of displacement rate is almost 5 mm/y through the monitoring for more than four years. At the northern-most potion of the Nankai (Suruga) Trough, the observed steady horizontal displacement rate is 45 mm/y toward west. Also no significant velocity difference is observed across the trough, indicating strong interplate locking up to the shallowest segments. On the other hand, site velocities are 40 mm/y in the direction of N75W at the central region of the Nankai trough, 70-90 km landward from the trough axis. Although this result is the strong evidence for interplate locking, with coupling ratios of 60-80% on the basis of the back-slip model, it has no resolution for the interplate locking at the most-shallowest segments whose depths are 0-10 km. In other words, seaward up-dip limit of locked zone is never resolved from the present seafloor benchmark network [Tadokoro et al., 2012] . Large co-seismic slips larger than 40-50 m on the shallowest interplate segment [Ito et al., 2011; Fujii et al., 2011; Iinuma et al., 2012] are the cause of the unexpected high tsunami that has attacked the pacific coasts of the Tohoku region during the Tohoku-oki Earthquake; it is, therefore, essential to understand slip deficit or strain accumulation condition near the trench axis, also for the anticipated mega-thrust earthquake at the Nankai Trough. For this reason, we

  4. Geodetic Imaging for Rapid Assessment of Earthquakes: Airborne Laser Scanning (ALS)

    Science.gov (United States)

    Carter, W. E.; Shrestha, R. L.; Glennie, C. L.; Sartori, M.; Fernandez-Diaz, J.; National CenterAirborne Laser Mapping Operational Center

    2010-12-01

    To the residents of an area struck by a strong earthquake quantitative information on damage to the infrastructure, and its attendant impact on relief and recovery efforts, is urgent and of primary concern. To earth scientists a strong earthquake offers an opportunity to learn more about earthquake mechanisms, and to compare their models with the real world, in hopes of one day being able to accurately predict the precise locations, magnitudes, and times of large (and potentially disastrous) earthquakes. Airborne laser scanning (also referred to as airborne LiDAR or Airborne Laser Swath Mapping) is particularly well suited for rapid assessment of earthquakes, both for immediately estimating the damage to infrastructure and for providing information for the scientific study of earthquakes. ALS observations collected at low altitude (500—1000m) from a relatively slow (70—100m/sec) aircraft can provide dense (5—15 points/m2) sets of surface features (buildings, vegetation, ground), extending over hundreds of square kilometers with turn around times of several hours to a few days. The actual response time to any given event depends on several factors, including such bureaucratic issues as approval of funds, export license formalities, and clearance to fly over the area to be mapped, and operational factors such as the deployment of the aircraft and ground teams may also take a number of days for remote locations. Of course the need for immediate mapping of earthquake damage generally is not as urgent in remote regions with less infrastructure and few inhabitants. During August 16-19, 2010 the National Center for Airborne Laser Mapping (NCALM) mapped the area affected by the magnitude 7.2 El Mayor-Cucapah Earthquake (Northern Baja California Earthquake), which occurred on April 4, 2010, and was felt throughout southern California, Arizona, Nevada, and Baja California North, Mexico. From initial ground observations the fault rupture appeared to extend 75 km

  5. Patient preference with respect to QoL and reduction in opioid-induced constipation (OIC) after treatment with prolonged-release (PR) oxycodone/naloxone compared with previous analgesic therapy [PREFER study].

    Science.gov (United States)

    van Dongen, V C P C; Vanelderen, P J L; Koopmans-Klein, G; van Megen, Y J B; Van Zundert, J; Huygen, F J P M

    2014-11-01

    The aim of this study was to assess patient preference in terms of quality of life (QoL), analgesia and bowel function for patients with moderate to severe chronic non-malignant pain, when treated with oxycodone PR/naloxone PR compared with the previous WHO-step I and/or WHO-step II analgesic treatment . This was a 3-week open-label phase 3b study conducted in Belgium and the Netherlands, after 3 weeks patients could enter an extension phase. Patient preference with respect to QoL for oxycodone PR/naloxone PR treatment compared with previous WHO-step I and/or WHO-step II analgesics was assessed. A patient was considered a responder with respect to QoL if this assessment was 'better' or 'much better' compared with previous WHO-step I or II analgesics at any time point. Response rate with respect to QoL was 59.2% (95% CI: 51.7-66.8%) for the Full Analysis (FA)-population, for the Per Protocol-population response rate was 71.7% (95% CI: 63.1-80.3%). Explorative analysis showed that response rate with respect to QoL was highest in constipated patients pretreated with WHO-step II analgesics (73.8%). Mean ± SD pain score in the FA-population at start was 74.7 ± 16.6 decreasing to 53.9 ± 24.3 after a median (range) treatment period of 173.5 (31-771) days. For constipated subjects the significant reduction in constipation [improvement of the Bowel Function Index (BFI)], was -24.8 points (95% CI: -17.1 to -32.5). BFI for non-constipated subjects remained well below 28.8. Adverse events with oxycodone PR/naloxone PR treatment were well-known opioid-related adverse events. This study shows that the studied patients previously treated with WHO-step I and/or WHO-step II analgesics prefer treatment with oxycodone PR/naloxone PR with respect to QoL. Moreover, the study shows that treatment with oxycodone PR/naloxone PR significantly reduces OIC in constipated patients and that non-constipated patients do not develop OIC during treatment with oxycodone PR/naloxone PR.

  6. [Placental complications after a previous cesarean section].

    Science.gov (United States)

    Milosević, Jelena; Lilić, Vekoslav; Tasić, Marija; Radović-Janosević, Dragana; Stefanović, Milan; Antić, Vladimir

    2009-01-01

    The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complication development. The research was conducted at the Clinic of Gynecology and Obstetrics in Nis covering 10-year-period (from 1995 to 2005) with 32358 deliveries, 1280 deliveries after a previous cesarean section, 131 cases of placenta previa and 118 cases of placental abruption. The experimental groups was presented by the cases of placenta previa or placental abruption with prior cesarean section in obstetrics history, opposite to the control group having the same conditions but without a cesarean section in medical history. The incidence of placenta previa in the control group was 0.33%, opposite to the 1.86% incidence after one cesarean section (pcesarean sections and as high as 14.28% after three cesarean sections in obstetric history. Placental abruption was recorded as placental complication in 0.33% pregnancies in the control group, while its incidence was 1.02% after one cesarean section (pcesarean sections. The difference in the incidence of intrapartal hysterectomy between the group with prior cesarean section (0.86%) and without it (0.006%) shows a high statistical significance (pcesarean section is an important risk factor for the development of placental complications.

  7. Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

    DEFF Research Database (Denmark)

    Lauenborg, J; Damm, P; Ek, J

    2004-01-01

    In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C......-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate...

  8. Evaluating Commercial and Private Cloud Services for Facility-Scale Geodetic Data Access, Analysis, and Services

    Science.gov (United States)

    Meertens, C. M.; Boler, F. M.; Ertz, D. J.; Mencin, D.; Phillips, D.; Baker, S.

    2017-12-01

    UNAVCO, in its role as a NSF facility for geodetic infrastructure and data, has succeeded for over two decades using on-premises infrastructure, and while the promise of cloud-based infrastructure is well-established, significant questions about suitability of such infrastructure for facility-scale services remain. Primarily through the GeoSciCloud award from NSF EarthCube, UNAVCO is investigating the costs, advantages, and disadvantages of providing its geodetic data and services in the cloud versus using UNAVCO's on-premises infrastructure. (IRIS is a collaborator on the project and is performing its own suite of investigations). In contrast to the 2-3 year time scale for the research cycle, the time scale of operation and planning for NSF facilities is for a minimum of five years and for some services extends to a decade or more. Planning for on-premises infrastructure is deliberate, and migrations typically take months to years to fully implement. Migrations to a cloud environment can only go forward with similar deliberate planning and understanding of all costs and benefits. The EarthCube GeoSciCloud project is intended to address the uncertainties of facility-level operations in the cloud. Investigations are being performed in a commercial cloud environment (Amazon AWS) during the first year of the project and in a private cloud environment (NSF XSEDE resource at the Texas Advanced Computing Center) during the second year. These investigations are expected to illuminate the potential as well as the limitations of running facility scale production services in the cloud. The work includes running parallel equivalent cloud-based services to on premises services and includes: data serving via ftp from a large data store, operation of a metadata database, production scale processing of multiple months of geodetic data, web services delivery of quality checked data and products, large-scale compute services for event post-processing, and serving real time data

  9. Geodetic mass balance of the Patagonian Icefields from STRM and TanDEM-X DEMs

    Science.gov (United States)

    Abdel Jaber, W.; Floricioiu, D.; Rott, H.

    2016-12-01

    The Northern and Southern Patagonian Icefields (NPI & SPI), represent the largest mid-latitude ice masses in the Southern Hemisphere. They are mostly drained by outlet glaciers with fronts calving into fresh water lakes or Pacific fjords. Both icefields were affected by significant downwasting in the last decades, as confirmed by published mass change trends obtained by means of gravimetric measurements and geodetic methods. Given their unique characteristics and the significant contribution to sea level rise per unit of area, they represent a fundamental barometer for climate research. The Shuttle Radar Topography Mission (SRTM) of 2000 provided the most complete and accurate Digital Elevation Model (DEM) at the time covering the entire globe from 56°S to 60°N. The present TanDEM-X mission shares the same objective aiming at a global coverage with much higher resolution and accuracy. Their combination leads to a unique multitemporal elevation dataset based solely on SAR single pass bistatic interferometry characterized by 11 to 16 year time span: an ideal setup for monitoring long-term large-scale geophysical phenomena. Using this dataset, detailed and extensive ice elevation change maps were obtained for the 12900 km² SPI for the observation period 2000 - 2011/2012 and for the 3900 km² NPI for the period 2000 - 2014. These maps were used to compute the glacier mass balance of the icefields through the geodetic method. Particular emphasis was set on the estimation of the uncertainty of the geodetic mass balance by quantifying all relevant sources of error. Among these, signal penetration into dry ice and snow can affect considerably radar elevation measurements. For this purpose the backscattering coefficient of the acquisitions along with concurrent meteorological data were analyzed to assess the conditions of the icefield surface. Mass change rates of -3.96±0.14 Gt a-1 and of -13.14±0.42 Gt a-1 (excluding subaqueous loss) were obtained for NPI and SPI

  10. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Directory of Open Access Journals (Sweden)

    Xingsheng Hu

    Full Text Available Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC previously treated with platinum-based chemotherapy.Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day. The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety.From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m and 5.4 months (95%CI 3.1-7.9 m, respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127, diarrhea (12.6%, 16/127 and elevation of transaminase (15.7%, 20/127.In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy.ClinicalTrials.gov NCT02486354.

  11. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Sachin A Narvekar

    2010-01-01

    Full Text Available Background: Management of repeated implantation failure despite transfer of good-quality embryos still remains a dilemma for ART specialists. Scrapping of endometrium in the nontransfer cycle has been shown to improve the pregnancy rate in the subsequent IVF/ET cycle in recent studies. Aim: The objective of this randomized controlled trial (RCT was to determine whether endometrial injury caused by Pipelle sampling in the nontransfer cycle could improve the probability of pregnancy in the subsequent IVF cycle in patients who had previous failed IVF outcome. Setting: Tertiary assisted conception center. Design: Randomized controlled study. Materials and Methods: 100 eligible patients with previous failed IVF despite transfer of good-quality embryos were randomly allocated to the intervention group and control groups. In the intervention group, Pipelle endometrial sampling was done twice: One in the follicular phase and again in the luteal phase in the cycle preceding the embryo transfer cycle. Outcome Measure: The primary outcome measure was live birth rate. The secondary outcome measures were implantation and clinical pregnancy rates. Results: The live birth rate was significantly higher in the intervention group compared to control group (22.4% and 9.8% P = 0.04. The clinical pregnancy rate in the intervention group was 32.7%, while that in the control group was 13.7%, which was also statistically significant ( P = 0.01. The implantation rate was significantly higher in the intervention group as compared to controls (13.07% vs 7.1% P = 0.04. Conclusions: Endometrial injury in nontransfer cycle improves the live birth rate,clinical pregnancy and implantation rates in the subsequent IVF-ET cycle in patients with previous unsuccessful IVF cycles.

  12. Geodezija od Mesopotamije do Globalnog geodetskog opažačkog sistema : Geodesy from Mesopotamie to Global Geodetic Observing System

    Directory of Open Access Journals (Sweden)

    Medžida Mulić

    2015-12-01

    Full Text Available Tokom šest milenijuma postojanja civilizacije na Zemlji, geodetske tehnike su doživjele teško sagledive promjene. Definicija i uloga geodezije su se mijenjale u skladu s tim promijenila. Geodezija (viša je evoluirala od svoje originalne klasične definicije da „proučava kretanja nebeskih tijela, oblik i dimenzije Zemlje“ u „znanost koja osim naprijed rečenog, proučava njene promjene i kompleksne dinamičke procese, koji djeluju unutar Zemlje, na njenoj površini i iznad njene površine, kao i u svemiru koji je okružuje. Rad predstavlja detaljan pregled geodetskih tehnika, instrumenata, katastra i kartografije kod starih civilizacija: Mesopotamije, starog Egipta, antičke Grčke, starog Rima, pa sve do Evropljana, između 17. stoljeća do modernog doba. Posebno su opisani geodetski radovi u Bosni i Hercegovini, od doba osmanlija, austro-ugarskog premjera, do savremenih dostignuća u polju premjera i primjene satelitskih modernih tehnika. Globalni geodetski opažački sistem-GGOS, glavna komponenta Internacionalne asocijacije za geodeziju, kao projekat za buduće generacije geodeta, opisan je na kraju. : During the six millennia of the existence of the civilization on the Earth, surveying techniques have been experienced difficult foreseeable changes. The definition and role of geodesy have been changing accordingly. Geodesy has evolved from its original classic definition that "studying the movements of celestial bodies, the shape and dimensions of the Earth" in the "science which, beside it noted above, studies its changes and complex dynamic processes that ongoing inside the Earth, on the surface, above its surfaces, and evironment. The paper is overview of the geodetic techniques and the surveying instruments, cadastre and cartography in the ancien civilizations: Mesopotamia, ancient Egypt, antic Greece, ancient Rome, to the Europeans, from the 17th century to modern times. A detailed description devoted to surveying and geodetic

  13. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

    Science.gov (United States)

    Unfer, Vittorio; Raffone, Emanuela; Rizzo, Piero; Buffo, Silvia

    2011-11-01

    Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality. Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle. After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion. The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

  14. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors.

    Science.gov (United States)

    von Pawel, J; von Roemeling, R; Gatzemeier, U; Boyer, M; Elisson, L O; Clark, P; Talbot, D; Rey, A; Butler, T W; Hirsh, V; Olver, I; Bergman, B; Ayoub, J; Richardson, G; Dunlop, D; Arcenas, A; Vescio, R; Viallet, J; Treat, J

    2000-03-01

    A phase III trial, Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors (CATAPULT I), was designed to determine the efficacy and safety of tirapazamine plus cisplatin for the treatment of non-small-cell lung cancer (NSCLC). Patients with previously untreated NSCLC were randomized to receive either tirapazamine (390 mg/m(2) infused over 2 hours) followed 1 hour later by cisplatin (75 mg/m(2) over 1 hour) or 75 mg/m(2) of cisplatin alone, every 3 weeks for a maximum of eight cycles. A total of 446 patients with NSCLC (17% with stage IIIB disease and pleural effusions; 83% with stage IV disease) were entered onto the study. Karnofsky performance status (KPS) was >/= 60 for all patients (for 10%, KPS = 60; for 90%, KPS = 70 to 100). Sixty patients (14%) had clinically stable brain metastases. The median survival was significantly longer (34.6 v 27. 7 weeks; P =.0078) and the response rate was significantly greater (27.5% v 13.7%; P CATAPULT I study shows that tirapazamine enhances the activity of cisplatin in patients with advanced NSCLC and confirms that hypoxia is an exploitable therapeutic target in human malignancies.

  15. A double-blind cross-over controlled study to evaluate the effect of human biosynthetic growth hormone on ovarian stimulation in previous poor responders to in-vitro fertilization.

    Science.gov (United States)

    Hughes, S M; Huang, Z H; Morris, I D; Matson, P L; Buck, P; Lieberman, B A

    1994-01-01

    The effect of exogenous human biosynthetic growth hormone (HGH; 12 IU/day; Norditropin, Novo-Nordisk) on the response to ovarian stimulation using a buserelin/human menopausal gonadotrophin (HMG) regimen was assessed in women who had previously shown a 'poor response' in spite of increasing doses of HMG. Forty patients were recruited into a prospective double-blind placebo-controlled study. The serum follicle stimulating hormone (FSH) on day 2-5 of a menstrual cycle (HGH compared to the placebo cycle resulted in increased serum concentrations of fasting insulin on the 8th (median 3.9 versus 5.8 mU/l; P HGH. After 8 days of co-treatment with HGH the number of cohort follicles (14-16.9 mm) was significantly increased, but this change was not sustained on the day of HCG administration. No statistical difference in the serum oestradiol on the 8th day of HMG or day of HCG, length of the follicular phase, total dose of HMG used, or the number of oocytes collected was seen between the placebo or HGH cycles. This study demonstrates that HGH does not improve the ovarian response to ovulation induction in previous poor responders.

  16. Processing of a geodetic network determined in ETRS-89 with application of different cofactors

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    Slavomír Labant

    2012-12-01

    Full Text Available At present, manufacturers characterize the accuracy of vectors measured by the static method of GNSS technology usingrelationship 5 mm + 1⋅ D ppm . The advantage of the GNSS system over other terrestrial technologies is that it is not affectedby uncertainties in the ground layers of the atmosphere. The paper presents experimental measurement of the 3D geodetic network usingthe technology of global navigation satellite systems, processing and analysis of measurements taken at the Čierny Váh pumping hydropowerstation. Observations were carried out in July 2008. The aim of the paper is to assess parameters used in the model to estimateparameters of the first and second order of the network structures.

  17. Optimization of observation plan based on the stochastic characteristics of the geodetic network

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    Pachelski Wojciech

    2016-06-01

    Full Text Available Optimal design of geodetic network is a basic subject of many engineering projects. An observation plan is a concluding part of the process. Any particular observation within the network has through adjustment a different contribution and impact on values and accuracy characteristics of unknowns. The problem of optimal design can be solved by means of computer simulation. This paper presents a new method of simulation based on sequential estimation of individual observations in a step-by-step manner, by means of the so-called filtering equations. The algorithm aims at satisfying different criteria of accuracy according to various interpretations of the covariance matrix. Apart of them, the optimization criterion is also amount of effort, defined as the minimum number of observations required.

  18. The Crustal Velocity Field Mosaic of the Alpine Mediterranean Area: Insight from New Geodetic Data

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    Farolfi, G.; Del Ventisette, C.

    2016-08-01

    Geodetic techniques, such as Global Navigation Satellite System (GNSS), Synthetic Aperture Radar (SAR), satellite gravity missions, etc., have made significant contributions in monitoring temporal and spatial changes in Earth's lithosphere and atmosphere.A new crustal velocity field for the Alpine Mediterranean area (Farolfi & Del Ventisette, 2015) was determined by using a time series spanning 6.5 years of GNSS permanent stations. Thus, processing was performed by using state-of-the-art antenna phase center model, new recomputed satellite orbits and a new more accurate tropospheric model.The aim of this work is to calculate and analyze the spatial variations of continuous time series of GNSS permanent stations, to estimate crustal velocities in the Alpine Mediterranean area. The resulting velocity field gives a strong contribution in the framework of the contemporary geodynamics.

  19. Geodetic measurement of deformation in the Ventura basin region, southern California

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    Donnellan, Andrea; Hager, Bradford H.; King, Robert W.; Herring, Thomas A.

    1993-12-01

    We have measured the deformation in the Ventura basin region, southern California, with Global Positioning System (GPS) measurements carried out over 4.6 years between 1987 and 1992. The deformation within our network is spatically variable on scales of tens of kilometers, with strain rates reaching 0.6 +/- 1 micro-rad/yr in the east-central basin. Blocklike rotations are observed south and northwest of the basin where the maximum shear strain rates are an order of magnitude lower (0.06 +/- 1 micro-rad/yr to the south). We also observed clockwise rotations of 1 deg - 7 deg/m.y. Shear strain rates determined by comparing angle changes from historical triangulation spanning several decades and GPS measurements give consistent, though less precise, results. The geodetic rates of shortening across the basin and Western Transverse Ranges are lower than those estimated from geological observations, but the patterns of deformation from the two methods agree qualitatively.

  20. Geodetic measurement of deformation east of the San Andreas Fault in Central California

    Science.gov (United States)

    Sauber, Jeanne; Solomon, Sean C.; Lisowski, Michael

    1988-01-01

    The shear strain rates in the Diablo Range of California have been calculated, and the slip rate along the Calaveras and Paicines faults in Central California have been estimated, on the basis of triangulation and trilateration data from two geodetic networks located between the western edge of the Great Valley and the San Andreas Fault. The orientation of the principal compressive strain predicted from the azimuth of the major structures in the region is N 25 deg E, leading to an average shear strain value that corresponds to a relative shortening rate of 4.5 + or - 2.4 mm/yr. It is inferred that the measured strain is due to compression across the fold of this area. The hypothesized uniform, fault-normal compression within the Coast Ranges is not supported by these results.

  1. Geodetic imaging of thermal deformation in geothermal reservoirs - production, depletion and fault reactivation

    Science.gov (United States)

    Im, Kyungjae; Elsworth, Derek; Guglielmi, Yves; Mattioli, Glen S.

    2017-05-01

    We investigate thermally induced surface deformation in geothermal systems. To define source mechanisms at depth, we assess the mechanical process of subsurface deformation by assuming a spherically cooled fractured reservoir in an infinite medium and derive relations that define magnitudes of thermal contraction, stress change and permeability evolution. The magnitude of thermal deformation in typical geothermal system is larger than anticipated and suggests two different modalities of surface subsidence - thermal contraction and fault reactivation. Here, surface deformation (vertical displacement, surface tilt and horizontal strain) induced by the two different modalities are assessed with Mogi (contraction) and Okada (slip) models and compared with instrumental sensitivity of high precision surface geodetic tools. We show that 1 year of geothermal operation at 10 MW with a power plant conversion efficiency of 12% can yield 3.0 × 104 m3 of subsurface volume change. For a reservoir at 2000 m depth, this induces 1.7 mm of vertical surface displacement, 800 nano-radians of surface tilt and 900 nano-strains of surface strain. This result implies that typically observed magnitudes of surface subsidence (order of cm/year) are naturally expected in massive (100 MW scale) geothermal operations and observed surface subsidence may largely be the result of thermal contraction. Conversely, thermal unloading can trigger fault reactivation. Analysis with an Okada slip model shows these shear offsets on pre-existing faults can also result in surface deformations of considerable magnitude. Our analysis of field operational data from various geothermal projects suggests that both thermal contraction and slow fault reactivation may contribute to the observed large surface deformation. Comparison of predicted deformation with instrumental sensitivity of high precision surface tools confirms that geodetic signals, especially tilt and strain, are indeed sufficiently large to

  2. Bortezomib Added to Daunorubicin and Cytarabine During Induction Therapy and to Intermediate-Dose Cytarabine for Consolidation in Patients With Previously Untreated Acute Myeloid Leukemia Age 60 to 75 Years: CALGB (Alliance) Study 10502

    Science.gov (United States)

    Attar, Eyal C.; Johnson, Jeffrey L.; Amrein, Philip C.; Lozanski, Gerard; Wadleigh, Martha; DeAngelo, Daniel J.; Kolitz, Jonathan E.; Powell, Bayard L.; Voorhees, Peter; Wang, Eunice S.; Blum, William; Stone, Richard M.; Marcucci, Guido; Bloomfield, Clara D.; Moser, Barry; Larson, Richard A.

    2013-01-01

    Purpose The purpose of this study was to determine remission induction frequency when bortezomib was combined with daunorubicin and cytarabine in previously untreated older adults with acute myeloid leukemia (AML) and safety of bortezomib in combination with consolidation chemotherapy consisting of intermediate-dose cytarabine (Int-DAC). Patients and Methods Ninety-five adults (age 60 to 75 years; median, 67 years) with previously untreated AML (including therapy-related and previous myelodysplastic syndrome) received bortezomib 1.3 mg/m2 intravenously (IV) on days 1, 4, 8, and 11 with daunorubicin 60 mg/m2 on days 1 through 3 and cytarabine 100 mg/m2 by continuous IV infusion on days 1 through 7. Patients who achieved complete remission (CR) received up to two courses of consolidation chemotherapy with cytarabine 2 gm/m2 on days 1 through 5 with bortezomib. Three cohorts with escalating dose levels of bortezomib were tested (0.7, 1.0, and 1.3 mg/m2). Dose-limiting toxicities were assessed during the first cycle of consolidation. The relationship between cell surface expression of CD74 and clinical outcome was assessed. Results Frequency of CR was 65% (62 of 95), and 4% of patients (four of 95) achieved CR with incomplete platelet recovery (CRp). Eleven patients developed grade 3 sensory neuropathy. Bortezomib plus Int-DAC proved tolerable at the highest dose tested. Lower CD74 expression was associated with CR/CRp (P = .04) but not with disease-free or overall survival. Conclusion The addition of bortezomib to standard 3 + 7 daunorubicin and cytarabine induction chemotherapy for AML resulted in an encouraging remission rate. The maximum tested dose of bortezomib administered in combination with Int-DAC for remission consolidation was 1.3 mg/m2 and proved tolerable. Further testing of this regimen is planned. PMID:23129738

  3. Como novos conhecimentos podem ser construídos a partir dos conhecimentos prévios: um estudo de caso How new knowledge can be constructed from previous knowledge: a case study

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    Francimar Martins Teixeira

    2010-01-01

    Full Text Available O presente artigo trata sobre o estudo de caso de como uma professora utiliza os conhecimentos prévios dos estudantes durante a abordagem de um novo conceito científico. Para tanto, foram realizadas filmagens de aulas de ciências durante a execução de uma sequência didática, a fim de investigar de que maneira os conhecimentos prévios dos estudantes eram tratados em sala de aula ao longo da abordagem do tema. A partir dos resultados encontrados, percebemos nas aulas observadas como a professora lidava com os conhecimentos dos estudantes. Identificamos que houve ocasiões em que ela os considerou e outras em que os desconsiderou. Apesar de ações antagônicas, tanto o fato de considerar quanto de desconsiderar parecem ter em comum a busca de manutenção de foco sob os conceitos, entendidos pela professora, como sendo os que devem ser objeto de atenção dos alunos.This article deals with a case study about how a teacher uses previous knowledge of students to approach a new concept. To this end, sciences classes were filmed during the execution of a didactic sequence, in order to investigate how previous knowledge of the students was treated in the classroom along the approach of the theme. From these results, we saw how the teacher dealt with previous knowledge of their students. We identified that there were occasions when she considered them and others in which she disregarded them. Although they are antagonistic actions, both the facts, to consider or to dismiss, have in common the search for keeping the focus on the concepts, defined by the teacher as those that should be the object of attention for the students.

  4. Geodetic networks in Al-Hoceima, Fez-Meknes and Ouarzazate regions (Morocco) to monitor local deformations

    Science.gov (United States)

    Gil, A. J.; Ruiz, A. M.; Lacy, M. C.; Galindo-Zaldívar, J.; Anahnah, F.; Ruano, P.; Álvarez-Lobato, P. Ayarza, F.; Arboleya, A. Teixel, M. L.; Azzouz, O.; Ahmamou, A. Chalouan, M.; Kchikach, A.

    2009-04-01

    In the framework of some interdisciplinary research projects, several geodetic studies have been initiated aiming to quantify ground deformation in some areas of Morocco: the Al-Hoceima region (Rif cordillera), the Fez-Meknes region and the Ouarzazate region (Atlas Mountains). The Al-Hoceima region, located in the central part of the Rif Cordilleras, has undergone an intense seismic activity, in which the most significant events occurred in 1994 and 2004 (M= 6.3). Although seismicity data support the presence of transcurrent faults, and available radar interferometry researches evidence surface deformations, geological data suggest that main seismogentic fault zone has not a surface expression. Anyway, a set of N-S oriented normal faults (Rouadi, Al-Hoceima, Trougout) determines the present-day geomorphology and seems to continue to be active in surface. In this area, a new non-permanent GPS network consisting of 6 sites has been installed and surveyed in June 2007 and September 2008. The repeated measurements of this network may allow to exactly determine the surface expression of deep tectonic deformations in this region, and to quantify the creep and the coseismic motions in the area, that will contribute to better understand the seismic hazard. The Prerif Ridges located in the Fez-Meknes region, constitute the active mountain front of the Rif cordillera that accommodates most of the recent convergence between Eurasia and African plates. South of the ridges, the Saïss foreland basin overlies the foreland rocks corresponding to the Middle Atlas. There are evidences of Quaternary uplift of the Prerif Ridges and deformation of recent sediments as consequence of the southwards propagation of reverse faults along the mountain front. In addition, the foreland basin undergoes a roughly N-S extensional regime. The region undergoes a moderate seismic activity, with catastrophic events like that occurred in 1755 which damaged Fez and Meknes. On September 2007, a non

  5. Slip distribution of the 2015 Mw 8.3 Illapel, Chile earthquake constrained by geodetic and seismological observations

    Science.gov (United States)

    LIU, C.; Shan, B.; Zheng, Y.; Xiong, X.

    2017-12-01

    On 16 September 2015, a magnitude Mw 8.3 interplate thrust earthquake ruptured a densely instrumented region in central Chile. The abundant datasets near and around the rupture zone provide a unique opportunity to study the detailed source process of this megathrust earthquake. We investigated the spatial and temporal distributions of the mainshock by a joint inversion of geodetic and seismological observations. Our optimized model shows that the primary slip zone is located in the north of the hypocenter with a maximum slip of 9.2 m, and the rupture scale extends 150 km along strike and 140 km along dip. Considering the strain accumulation, the 9.2 m of peak coseismic slip largely exceeds the 4.9 m slip deficit accumulated since 1943 Mw 7.9 event assuming a full coupling. The total seismic moment is 3.04×1021N·m, equivalent to Mw 8.3. Most seismic moment was released within 140 s. The rupture propagated in main slip asperity with a velocity of 2.0 km/s. We find that the aftershocks distributions have a clear complementary distribution with the co-seismic rupture pattern, aftershock clusters are found at the edge of unbroken barriers, and regions of rapid transition from high to low slip within the main fault area. Our results reveal that the low frequency radiation is associated with the large coseismic slip at the shallower portion of the megathrust whereas the high frequency radiation corresponds to isolated patches at greater depths. Based on the Coulomb stress change caused by the main rupture, 80% of aftershocks with focal mechanism are promoted for failure.

  6. Induced vaginal birth after previous caesarean section

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    Akylbek Tussupkaliyev

    2016-11-01

    Full Text Available Introduction The rate of operative birth by Caesarean section is constantly rising. In Kazakhstan, it reaches 27 per cent. Research data confirm that the percentage of successful vaginal births after previous Caesarean section is 50–70 per cent. How safe the induction of vaginal birth after Caesarean (VBAC remains unclear. Methodology The studied techniques of labour induction were amniotomy of the foetal bladder with the vulsellum ramus, intravaginal administration of E1 prostaglandin (Misoprostol, and intravenous infusion of Oxytocin-Richter. The assessment of rediness of parturient canals was conducted by Bishop’s score; the labour course was assessed by a partogram. The effectiveness of labour induction techniques was assessed by the number of administered doses, the time of onset of regular labour, the course of labour and the postpartum period and the presence of complications, and the course of the early neonatal period, which implied the assessment of the child’s condition, described in the newborn development record. The foetus was assessed by medical ultrasound and antenatal and intranatal cardiotocography (CTG. Obtained results were analysed with SAS statistical processing software. Results The overall percentage of successful births with intravaginal administration of Misoprostol was 93 per cent (83 of cases. This percentage was higher than in the amniotomy group (relative risk (RR 11.7 and was similar to the oxytocin group (RR 0.83. Amniotomy was effective in 54 per cent (39 of cases, when it induced regular labour. Intravenous oxytocin infusion was effective in 94 per cent (89 of cases. This percentage was higher than that with amniotomy (RR 12.5. Conclusions The success of vaginal delivery after previous Caesarean section can be achieved in almost 70 per cent of cases. At that, labour induction does not decrease this indicator and remains within population boundaries.

  7. Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: results from the recidivism of alcohol-impaired driving (ROAD) study.

    Science.gov (United States)

    Maenhout, Thomas M; Poll, Anneleen; Vermassen, Tijl; De Buyzere, Marc L; Delanghe, Joris R

    2014-01-01

    In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. A logistic regression analysis revealed that ln(%CDT) (P drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index ≥ 25%; third tertile) could be distinguished from drivers with an intermediate risk (16% ≤ ROAD index drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism. © 2013 Society for the Study of Addiction.

  8. Continuous terrestrial geodetic monitoring of the 2007 Lava Fan in the Sciara de Fuoco (Stromboli volcano, Italy)

    Science.gov (United States)

    Puglisi, G.; Bonforte, A.; Cantarero, M.; Spata, A.

    2009-12-01

    At the end of the 2002-2003 eruption, a terrestrial monitoring system was set up to regularly measure the movements of benchmarks installed inside the Sciara del Fuoco (hereafter SdF) (Puglisi et al., 2005). This system, named THEODOROS, is based on a remotely controlled robotized Total Station installed near Punta Labronzo, on the northern border of the SdF. The 2007 eruption caused a dramatic change in the operations of THEODOROS. Indeed, the 2007 lava flows destroyed all the benchmarks installed on the northern part of the SdF, leaving only those on its central part. This eruption produced a lava fan at the base of the SdF, due to the rapid cooling of the lava flows on entering the sea. The continuous overlapping of several flows during the eruption built a thick lava body (the fan); it was emplaced on a very steep slope, partially originated during the landslides occurring in December 2002, producing a hazardous condition due to the potential sudden sliding of this fan into the sea. In order to monitor the stability of this lava fan, a new terrestrial geodetic network, was implemented on 6 April 2007, by installing 5 reflectors along a profile crossing the lava body, approximately over the old coastline. Later, in June 2007, 4 more reflectors were installed at higher and lower altitudes with respect to the previous profile, to obtain more information on the overall deformation of the lava body. Measurements were rather noisy during the first months, but a better definition of the reference system strongly improved the quality of the data. The position of the 9 benchmarks over the lava fan enable the areal distribution of the deformation to be drawn. The measurements carried out every 10 minutes allow following their motion with high temporal detail. The data collected since the end of the eruption highlighted a significant downslope motion of the entire lava fan, decreasing from the South to the North, where the body is buttressed by the rocky northern wall of

  9. MOONLIGHT: A NEW LUNAR LASER RANGING RETROREFLECTOR AND THE LUNAR GEODETIC PRECESSION

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    M. Martini

    2013-12-01

    Full Text Available Since the 1970s Lunar Laser Ranging (LLR to the Apollo Cube Corner Retroreflector (CCR arrays (developed by the University of Maryland, UMD supplied almost all significant tests of General Relativity (Alley et al., 1970; Chang et al., 1971; Bender et al.,1973: possible changes in the gravitational constant, gravitational self-energy, weak equivalence principle, geodetic precession, inverse-square force-law. The LNF group, in fact, has just completed a new measurement of the lunar geodetic precession with Apollo array, with accuracy of 9 × 10−3, comparable to the best measurement to date. LLR has also provided significant information on the composition and origin of the moon. This is the only Apollo experiment still in operation. In the 1970s Apollo LLR arrays contributed a negligible fraction of the ranging error budget. Since the ranging capabilities of ground stations improved by more than two orders of magnitude, now, because of the lunar librations, Apollo CCR arrays dominate the error budget. With the project MoonLIGHT (Moon Laser Instrumentation for General relativity High-accuracy Tests, in 2006 INFN-LNF joined UMD in the development and test of a new-generation LLR payload made by a single, large CCR (100mm diameter unaffected by the effect of librations. With MoonLIGHT CCRs the accuracy of the measurement of the lunar geodetic precession can be improved up to a factor 100 compared to Apollo arrays. From a technological point of view, INFN-LNF built and is operating a new experimental apparatus (Satellite/lunar laser ranging Characterization Facility, SCF and created a new industry-standard test procedure (SCF-Test to characterize and model the detailed thermal behavior and the optical performance of CCRs in accurately laboratory-simulated space conditions, for industrial and scientific applications. Our key experimental innovation is the concurrent measurement and modeling of the optical Far Field Diffraction Pattern (FFDP and the

  10. The potential role of real-time geodetic observations in tsunami early warning

    Science.gov (United States)

    Tinti, Stefano; Armigliato, Alberto

    2016-04-01

    experimental or testing stage and haven't been implemented yet in any standard TWS operations. Nonetheless, this is seen to be the future and the natural TWS evolving enhancement. In this context, improvement of the real-time estimates of tsunamigenic earthquake focal mechanism is of fundamental importance to trigger the appropriate computational chain. Quick discrimination between strike-slip and thrust-fault earthquakes, and equally relevant, quick assessment of co-seismic on-fault slip distribution, are exemplary cases to which a real-time geodetic monitoring system can contribute significantly. Robust inversion of geodetic data can help to reconstruct the sea floor deformation pattern especially if two conditions are met: the source is not too far from network stations and is well covered azimuthally. These two conditions are sometimes hard to satisfy fully, but in certain regions, like the Mediterranean and the Caribbean sea, this is quite possible due to the limited size of the ocean basins. Close cooperation between the Global Geodetic Observing System (GGOS) community, seismologists, tsunami scientists and TWS operators is highly recommended to obtain significant progresses in the quick determination of the earthquake source, which can trigger a timely estimation of the ensuing tsunami and a more reliable and detailed assessment of the tsunami size at the coast.

  11. Rates of induced abortion in Denmark according to age, previous births and previous abortions

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    Marie-Louise H. Hansen

    2009-11-01

    Full Text Available Background: Whereas the effects of various socio-demographic determinants on a woman's risk of having an abortion are relatively well-documented, less attention has been given to the effect of previous abortions and births. Objective: To study the effect of previous abortions and births on Danish women's risk of an abortion, in addition to a number of demographic and personal characteristics. Data and methods: From the Fertility of Women and Couples Dataset we obtained data on the number of live births and induced abortions by year (1981-2001, age (16-39, county of residence and marital status. Logistic regression analysis was used to estimate the influence of the explanatory variables on the probability of having an abortion in a relevant year. Main findings and conclusion: A woman's risk of having an abortion increases with the number of previous births and previous abortions. Some interactions were was found in the way a woman's risk of abortion varies with calendar year, age and parity. The risk of an abortion for women with no children decreases while the risk of an abortion for women with children increases over time. Furthermore, the risk of an abortion decreases with age, but relatively more so for women with children compared to childless women. Trends for teenagers are discussed in a separate section.

  12. THE ROLE OF ASTRO-GEODETIC IN PRECISE GUIDANCE OF LONG TUNNELS

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    M. Mirghasempour

    2015-12-01

    Full Text Available One of prime aspects of surveying projects is guidance of paths of a long tunnel from different directions and finally ending all paths in a specific place. This kind of underground surveying, because of particular condition, has some different points in relation to the ground surveying, including Improper geometry in underground transverse, low precise measurement in direction and length due to condition such as refraction, distinct gravity between underground point and corresponding point on the ground (both value and direction of gravity and etc. To solve this problems, astro-geodetic that is part of geodesy science, can help surveying engineers. In this article, the role of astronomy is defined in two subjects: 1- Azimuth determination of directions from entrance and exit nets of tunnel and also calibration of gyro-theodolite to use them in Underground transvers: By astronomical methods, azimuth of directions can be determine with an accuracy of 0.5 arcsecond, whereas, nowadays, no gyroscope can measure the azimuth in this accuracy; For instance, accuracy of the most precise gyroscope (Gyromat 5000 is 1.2 cm over a distance of one kilometre (2.4 arcsecond. Furthermore, the calibration methods that will be mention in this article, have significance effects on underground transverse. 2- Height relation between entrance point and exit point is problematic and time consuming; For example, in a 3 km long tunnel ( in Arak- Khoram Abad freeway, to relate entrance point to exit point, it is necessary to perform levelling about 90 km. Other example of this boring and time consuming levelling is in Kerman tunnel. This tunnel is 36 km length, but to transfer the entrance point height to exit point, 150 km levelling is needed. According to this paper, The solution for this difficulty is application of astro-geodetic and determination of vertical deflection by digital zenith camera system TZK2-D. These two elements make possible to define geoid profile

  13. Seismicity and seismic hazard in Sabah, East Malaysia from earthquake and geodetic data

    Science.gov (United States)

    Gilligan, A.; Rawlinson, N.; Tongkul, F.; Stephenson, R.

    2017-12-01

    While the levels of seismicity are low in most of Malaysia, the state of Sabah in northern Borneo has moderate levels of seismicity. Notable earthquakes in the region include the 1976 M6.2 Lahad Datu earthquake and the 2015 M6 Ranau earthquake. The recent Ranau earthquake resulted in the deaths of 18 people on Mt Kinabalu, an estimated 100 million RM ( US$23 million) damage to buildings, roads, and infrastructure from shaking, and flooding, reduced water quality, and damage to farms from landslides. Over the last 40 years the population of Sabah has increased to over four times what it was in 1976, yet seismic hazard in Sabah remains poorly understood. Using seismic and geodetic data we hope to better quantify the hazards posed by earthquakes in Sabah, and thus help to minimize risk. In order to do this we need to know about the locations of earthquakes, types of earthquakes that occur, and faults that are generating them. We use data from 15 MetMalaysia seismic stations currently operating in Sabah to develop a region-specific velocity model from receiver functions and a pre-existing surface wave model. We use this new velocity model to (re)locate earthquakes that occurred in Sabah from 2005-2016, including a large number of aftershocks from the 2015 Ranau earthquake. We use a probabilistic nonlinear earthquake location program to locate the earthquakes and then refine their relative locations using a double difference method. The recorded waveforms are further used to obtain moment tensor solutions for these earthquakes. Earthquake locations and moment tensor solutions are then compared with the locations of faults throughout Sabah. Faults are identified from high-resolution IFSAR images and subsequent fieldwork, with a particular focus on the Lahad Datau and Ranau areas. Used together, these seismic and geodetic data can help us to develop a new seismic hazard model for Sabah, as well as aiding in the delivery of outreach activities regarding seismic hazard

  14. Congruency sequence effects are driven by previous-trial congruency, not previous-trial response conflict

    OpenAIRE

    Weissman, Daniel H.; Carp, Joshua

    2013-01-01

    Congruency effects in distracter interference tasks are often smaller after incongruent trials than after congruent trials. However, the sources of such congruency sequence effects (CSEs) are controversial. The conflict monitoring model of cognitive control links CSEs to the detection and resolution of response conflict. In contrast, competing theories attribute CSEs to attentional or affective processes that vary with previous-trial congruency (incongruent vs. congruent). The present study s...

  15. Data Records derived from GEOSAT Geodetic Mission (GM) and Exact Repeat Mission (ERM) data from 30 March 1985 to 31 December 1989

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection contains Sensor Data Records (SDRs), Geodetic Data Records (GDRs), Waveform Data Records (WDRs), and Crossover Difference data Records (XDRs) from...

  16. A Phase II Study of the c-Met Inhibitor Tivantinib in Combination with FOLFOX for the Treatment of Patients with Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction, or Stomach.

    Science.gov (United States)

    Pant, Shubham; Patel, Manish; Kurkjian, Carla; Hemphill, Brian; Flores, Maria; Thompson, Dana; Bendell, Johanna

    2017-08-09

    This phase I/II study was designed to determine the maximum tolerated dose of tivantinib in combination with standard dose FOLFOX for the treatment of patients with advanced solid tumors and to evaluate the safety and efficacy of this combination for patients with previously untreated metastatic adenocarcinoma of the distal esophagus, gastroesophageal (GE) junction, or stomach. Patients with advanced solid tumors for which FOLFOX would be appropriate chemotherapy received escalating doses of tivantinib BID (days 1-14) in a standard 3 + 3 design in phase I. In phase II, patients with advanced GE cancer received standard FOLFOX day 1 and tivantinib (360 mg PO BID) days 1-14 of each 2-week cycle. Restaging occurred every four cycles. The primary phase II endpoint was response rate (RR). Forty-nine patients were enrolled (15 on phase I and 34 on phase II). The expansion dose was established as tivantinib 360 mg BID in combination with FOLFOX. Thirty-two phase II patients were treated for a median of eight cycles (range, 1-38), with an overall RR of 38%. Treatment-related toxicities included neutropenia, fatigue, diarrhea, nausea, and peripheral neuropathy. Median progression-free survival (PFS) was 6.1 hmonths with a median time to progression of 7.0 months. Median overall survival was 9.6 months. Two patients remain on study at the time of this analysis. The combination treatment of tivantinib plus FOLFOX in patients with advanced GE cancer showed a response and PFS in the range of historical controls for first-line FOLFOX therapy. However, two patients had extended time on study treatment (36 and 45 cycles) at the time of data cutoff.

  17. Fault location and source process of the Boumerdes, Algeria, earthquake inferred from geodetic and strong motion data

    Science.gov (United States)

    Semmane, Fethi; Campillo, Michel; Cotton, Fabrice

    2005-01-01

    The Boumerdes earthquake occurred on a fault whose precise location, offshore the Algerian coast, was unknown. Geodetic data are used to determine the absolute position of the fault. The fault might emerge at about 15 km offshore. Accelerograms are used to infer the space-time history of the rupture using a two-step inversion in the spectral domain. The observed strong motion records agree with the synthetics for the fault location inferred from geodetic data. The fault plane ruptured for about 18 seconds. The slip distribution on the fault indicates one asperity northwest of the hypocenter with maximum slip amplitude about 3 m. This asperity is probably responsible for most of the damage. Another asperity with slightly smaller slip amplitude is located southeast of the hypocenter. The rupture stops its westward propagation close to the Thenia fault, a structure almost perpendicular to the main fault.

  18. Robust adjustment of a geodetic network measured by satellite technology in the Dargovských Hrdinov suburb

    Directory of Open Access Journals (Sweden)

    Slavomír Labant

    2011-12-01

    Full Text Available This article addresses the adjustment of a 3D geodetic network in the Dargovských Hrdinov suburbs using Global Navigation SatelliteSystems (GNSS for the purposes of deformation analysis. The advantage of using the GNSS compared to other terrestrial technology is thatit is not influenced by unpredictability in the ground level atmosphere and individual visibilities between points in the observed network arenot necessary. This article also includes the planning of GNSS observations using Planning Open Source software from Trimble as well assubsequent observations at individual network points. The geodetic network is processing on the basis of the Gauss-Markov model usingthe least square method and robust adjustment. From robust methods, Huber’s Robust M-estimation and Hampel’s Robust M-estimationwere used. Individual adjustments were tested and subsequently the results of analysis were graphically visualised using absolute confidenceellipsoids.

  19. A school-based program implemented by community providers previously trained for the prevention of eating and weight-related problems in secondary-school adolescents: the MABIC study protocol

    Science.gov (United States)

    2013-01-01

    Background The prevention of eating disorders and disordered eating are increasingly recognized as public health priorities. Challenges in this field included moving from efficacy to effectiveness and developing an integrated approach to the prevention of a broad spectrum of eating and weight-related problems. A previous efficacy trial indicated that a universal disordered eating prevention program, based on the social cognitive model, media literacy educational approach and cognitive dissonance theory, reduced risk factors for disordered eating, but it is unclear whether this program has effects under more real-world conditions. The main aim of this effectiveness trial protocol is to test whether this program has effects when incorporating an integrated approach to prevention and when previously-trained community providers implement the intervention. Methods/design The research design involved a multi-center non-randomized controlled trial with baseline, post and 1-year follow-up measures. Six schools from the city of Sabadell (close to Barcelona) participated in the intervention group, and eleven schools from four towns neighboring Sabadell participated in the control group. A total of 174 girls and 180 boys in the intervention group, and 484 girls and 490 boys in the control group were registered in class lists prior to baseline. A total of 18 community providers, secondary-school class tutors, nurses from the Catalan Government’s Health and School Program, and health promotion technicians from Sabadell City Council were trained and delivered the program. Shared risk factors of eating and weight-related problems were assessed as main measures. Discussion It will be vital for progress in disordered eating prevention to conduct effectiveness trials, which test whether interventions are effective when delivered by community providers under ecologically valid conditions, as opposed to tightly controlled research trials. The MABIC project will provide new

  20. A school-based program implemented by community providers previously trained for the prevention of eating and weight-related problems in secondary-school adolescents: the MABIC study protocol.

    Science.gov (United States)

    Sánchez-Carracedo, David; López-Guimerà, Gemma; Fauquet, Jordi; Barrada, Juan Ramón; Pàmias, Montserrat; Puntí, Joaquim; Querol, Mireia; Trepat, Esther

    2013-10-12

    The prevention of eating disorders and disordered eating are increasingly recognized as public health priorities. Challenges in this field included moving from efficacy to effectiveness and developing an integrated approach to the prevention of a broad spectrum of eating and weight-related problems. A previous efficacy trial indicated that a universal disordered eating prevention program, based on the social cognitive model, media literacy educational approach and cognitive dissonance theory, reduced risk factors for disordered eating, but it is unclear whether this program has effects under more real-world conditions. The main aim of this effectiveness trial protocol is to test whether this program has effects when incorporating an integrated approach to prevention and when previously-trained community providers implement the intervention. The research design involved a multi-center non-randomized controlled trial with baseline, post and 1-year follow-up measures. Six schools from the city of Sabadell (close to Barcelona) participated in the intervention group, and eleven schools from four towns neighboring Sabadell participated in the control group. A total of 174 girls and 180 boys in the intervention group, and 484 girls and 490 boys in the control group were registered in class lists prior to baseline. A total of 18 community providers, secondary-school class tutors, nurses from the Catalan Government's Health and School Program, and health promotion technicians from Sabadell City Council were trained and delivered the program. Shared risk factors of eating and weight-related problems were assessed as main measures. It will be vital for progress in disordered eating prevention to conduct effectiveness trials, which test whether interventions are effective when delivered by community providers under ecologically valid conditions, as opposed to tightly controlled research trials. The MABIC project will provide new contributions in this transition from efficacy

  1. The combined geodetic network adjusted on the reference ellipsoid – a comparison of three functional models for GNSS observations

    Directory of Open Access Journals (Sweden)

    Kadaj Roman

    2016-12-01

    Full Text Available The adjustment problem of the so-called combined (hybrid, integrated network created with GNSS vectors and terrestrial observations has been the subject of many theoretical and applied works. The network adjustment in various mathematical spaces was considered: in the Cartesian geocentric system on a reference ellipsoid and on a mapping plane. For practical reasons, it often takes a geodetic coordinate system associated with the reference ellipsoid. In this case, the Cartesian GNSS vectors are converted, for example, into geodesic parameters (azimuth and length on the ellipsoid, but the simple form of converted pseudo-observations are the direct differences of the geodetic coordinates. Unfortunately, such an approach may be essentially distorted by a systematic error resulting from the position error of the GNSS vector, before its projection on the ellipsoid surface. In this paper, an analysis of the impact of this error on the determined measures of geometric ellipsoid elements, including the differences of geodetic coordinates or geodesic parameters is presented. Assuming that the adjustment of a combined network on the ellipsoid shows that the optimal functional approach in relation to the satellite observation, is to create the observational equations directly for the original GNSS Cartesian vector components, writing them directly as a function of the geodetic coordinates (in numerical applications, we use the linearized forms of observational equations with explicitly specified coefficients. While retaining the original character of the Cartesian vector, one avoids any systematic errors that may occur in the conversion of the original GNSS vectors to ellipsoid elements, for example the vector of the geodesic parameters. The problem is theoretically developed and numerically tested. An example of the adjustment of a subnet loaded from the database of reference stations of the ASG-EUPOS system was considered for the preferred functional

  2. THE LIS STUDY (LYUBERTSY STUDY ON MORTALITY RATE IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION. EVALUATION OF DRUG THERAPY. PART 2. INFLUENCE OF PREVIOUS DRUG TREATMENT ON LONG-TERM LIFE PROGNOSIS

    Directory of Open Access Journals (Sweden)

    S. Yu. Martsevich

    2012-01-01

    Full Text Available Aim. To evaluate drug therapy received by patients who had survived acute myocardial infarction (AMI in the framework of the AMI register (the “LIS” study and estimate this therapy influence on long-term outcomes of the disease. Material and methods. The total of 961 patients of 1133 enrolled in the “LIS” study , were discharged from hospital. 191 patients had died during follow-up. 632 patients (who had survived and consented to visit out-patient clinic underwent repeated examination (median of follow-up 1.6 [1.0; 2.4] years. Data about treatment before and during AMI were received from patient’s charts; data about treatment after AMI were obtained from out-patient medical records. Results. Before reference AMI only a small number of the patients received the main drug groups (antiplatelet agents, β-blockers, ACE inhibitors, statins, at that ACE inhibitors were prescribed more often than the others. Use of β-blockers and ACE inhibitors before reference AMI significantly improved long-term life prognosis [relative risk (RR 0.70 and 0.66, respectively]. Rate of the main drug groups prescribed in hospital was rather high with the exception of thrombolytics (less than 10%. Thrombolytics, β-blockers and antiplatelet agents prescribed in hospital significantly improved long-term life prognosis of patients (RR 0.42, 0.65 and 0.58 respectively. At the second visit (according to data of out-patient medical records rate of antiplatelet agents, ACE inhibitors, β-blockers and statins prescription exceeded 60%. Conclusion. Very low prevalence of adequate drug therapy preceding AMI determines high mortality rate among survived acute stage of myocardial infarction patients in long-term period.

  3. THE LIS STUDY (LYUBERTSY STUDY ON MORTALITY RATE IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION. EVALUATION OF DRUG THERAPY. PART 2. INFLUENCE OF PREVIOUS DRUG TREATMENT ON LONG-TERM LIFE PROGNOSIS

    Directory of Open Access Journals (Sweden)

    S. Yu. Martsevich

    2015-12-01

    Full Text Available Aim. To evaluate drug therapy received by patients who had survived acute myocardial infarction (AMI in the framework of the AMI register (the “LIS” study and estimate this therapy influence on long-term outcomes of the disease. Material and methods. The total of 961 patients of 1133 enrolled in the “LIS” study , were discharged from hospital. 191 patients had died during follow-up. 632 patients (who had survived and consented to visit out-patient clinic underwent repeated examination (median of follow-up 1.6 [1.0; 2.4] years. Data about treatment before and during AMI were received from patient’s charts; data about treatment after AMI were obtained from out-patient medical records. Results. Before reference AMI only a small number of the patients received the main drug groups (antiplatelet agents, β-blockers, ACE inhibitors, statins, at that ACE inhibitors were prescribed more often than the others. Use of β-blockers and ACE inhibitors before reference AMI significantly improved long-term life prognosis [relative risk (RR 0.70 and 0.66, respectively]. Rate of the main drug groups prescribed in hospital was rather high with the exception of thrombolytics (less than 10%. Thrombolytics, β-blockers and antiplatelet agents prescribed in hospital significantly improved long-term life prognosis of patients (RR 0.42, 0.65 and 0.58 respectively. At the second visit (according to data of out-patient medical records rate of antiplatelet agents, ACE inhibitors, β-blockers and statins prescription exceeded 60%. Conclusion. Very low prevalence of adequate drug therapy preceding AMI determines high mortality rate among survived acute stage of myocardial infarction patients in long-term period.

  4. From “Mr. Guthrie is profoundly mistaken ...” to “Our data do not seem to confirm the results of a previous study on...”: A diachronic study of polemicity in academic writing (1810-1995

    Directory of Open Access Journals (Sweden)

    Françoise Salager-Meyer

    1999-04-01

    Full Text Available Objective: The objective of this paper is to investigate the quantitative and qualitative diachronic evolution of critical (Cr with respect to non-critical (NCr references in English medical discourse over a 185 year-period.Materials and Methods: We analyzed a corpus of 90 medical articles drawn from 34 different journals published between 1810 and 1995. Cr and NCr references were recorded in each paper and their frequency of occurrence was computed per 20 year-period. Results were analyzed by means of Chi-square tests.Results: Our quantitative results indicate that in the corpus as a whole NCr significantly outweigh Cr references. When diachronically analyzed, our quantitative data revealed that the corpus analyzed could be divided into 2 blocks: Block A (1810-1929 and Block B (1930-1995, the cutting point being the 1930’s when NCr references started exhibiting a dramatic ascent. Our findings further showed that, proportionally speaking, Cr references were significantly more frequent in Block A than in Block B, but that NCr references significantly outnumbered Cr ones in Block B. Our quantitative data also indicated that the NCr/Cr reference ratio remained rather constant for the first 120 years studied, but that it changed radically from the 1930’s. Finally, our qualitative findings revealed that 19th and early 20th century Cr references were formulated in a much more direct, involved, personal and author-responsible manner than their mid- and late 20th century counterparts, the rhetorical features of the latter being a pronounced hedginess and the shifting of the disagreeement responsibility from a human agent (who became a detached and apparently neutral actor to an inanimate “talking fact/finding” which is then given a prominent thematic position.Conclusions: We conclude that 19th and early 20th century medical papers adopted a critical stand more frequently than mid- and late 20th century medical discourse did, and that the

  5. Magma discharge variations during the 2011 eruptions of Shinmoe-dake volcano, Japan, revealed by geodetic and satellite observations

    Science.gov (United States)

    Kozono, Tomofumi; Ueda, Hideki; Ozawa, Taku; Koyaguchi, Takehiro; Fujita, Eisuke; Tomiya, Akihiko; Suzuki, Yujiro J.

    2013-03-01

    We present precise geodetic and satellite observation-based estimations of the erupted volume and discharge rate of magma during the 2011 eruptions of Kirishima-Shinmoe-dake volcano, Japan. During these events, the type and intensity of eruption drastically changed within a week, with three major sub-Plinian eruptions on January 26 and 27, and a continuous lava extrusion from January 29 to 31. In response to each eruptive event, borehole-type tiltmeters detected deflation of a magma chamber caused by migration of magma to the surface. These measurements enabled us to estimate the geodetic volume change in the magma chamber caused by each eruptive event. Erupted volumes and discharge rates were constrained during lava extrusion using synthetic aperture radar satellite imaging of lava accumulation inside the summit crater. Combining the geodetic volume change and the volume of lava extrusion enabled the determination of the erupted volume and discharge rate during each sub-Plinian event. These precise estimates provide important information about magma storage conditions in magma chambers and eruption column dynamics, and indicate that the Shinmoe-dake eruptions occurred in a critical state between explosive and effusive eruption.

  6. ALGORITHMS VARIANTS OF ELABORATION OF THE PRECISE GNSS NETWORK ESTABLISHED FOR GEODETIC SERVICE OF BUILDING OF THE MINING FACILITY

    Directory of Open Access Journals (Sweden)

    Ryszard MIELIMĄKA

    2014-10-01

    Full Text Available The article presents the problem of the usage of post‐processing services of the ASG‐EUPOS system on the example of GNSS network established for geodetic service of building of the inclined drift, to make coal deposit accessible, and also building associated objects. For the purpose of geodetic service of construction realization network was established outside the planned objects. The network consists of six new ground points and four control points belonging to ASG‐EUPOS network. Simultaneous, static measurements of the network were performed in three‐hour observation session, using multi‐frequency and multi‐system satellite receivers – Trimble R8. The paper presents three variants of post‐processing of the observation results. Calculations were performed using POZGEO‐D service and geodetic software package GEONET. The results of the calculation process revealed, that homogeneous vector networks should be adjusted on the ellipsoid or in the geocentric system. Model of adjustment of the vector network on the plane adopted in the GEONET software package should not be applied for elaboration of this type of network (long reference vectors more than 50km.

  7. Geodetic Finite-Fault-based Earthquake Early Warning Performance for Great Earthquakes Worldwide

    Science.gov (United States)

    Ruhl, C. J.; Melgar, D.; Grapenthin, R.; Allen, R. M.

    2017-12-01

    GNSS-based earthquake early warning (EEW) algorithms estimate fault-finiteness and unsaturated moment magnitude for the largest, most damaging earthquakes. Because large events are infrequent, algorithms are not regularly exercised and insufficiently tested on few available datasets. The Geodetic Alarm System (G-larmS) is a GNSS-based finite-fault algorithm developed as part of the ShakeAlert EEW system in the western US. Performance evaluations using synthetic earthquakes offshore Cascadia showed that G-larmS satisfactorily recovers magnitude and fault length, providing useful alerts 30-40 s after origin time and timely warnings of ground motion for onshore urban areas. An end-to-end test of the ShakeAlert system demonstrated the need for GNSS data to accurately estimate ground motions in real-time. We replay real data from several subduction-zone earthquakes worldwide to demonstrate the value of GNSS-based EEW for the largest, most damaging events. We compare predicted ground acceleration (PGA) from first-alert-solutions with those recorded in major urban areas. In addition, where applicable, we compare observed tsunami heights to those predicted from the G-larmS solutions. We show that finite-fault inversion based on GNSS-data is essential to achieving the goals of EEW.

  8. Interior structure of terrestrial planets: Modeling Mars' mantle and its electromagnetic, geodetic, and seismic properties

    Science.gov (United States)

    Verhoeven, O.; Rivoldini, A.; Vacher, P.; Mocquet, A.; Choblet, G.; Menvielle, M.; Dehant, V.; Van Hoolst, T.; Sleewaegen, J.; Barriot, J.-P.; Lognonné, P.

    2005-04-01

    We present a new procedure to describe the one-dimensional thermodynamical state and mineralogy of any Earth-like planetary mantle, with Mars as an example. The model parameters are directly related to expected results from a geophysical network mission, in this case electromagnetic, geodetic, and seismological processed observations supplemented with laboratory measurements. We describe the internal structure of the planet in terms of a one-dimensional model depending on a set of eight parameters: for the crust, the thickness and the mean density, for the mantle, the bulk volume fraction of iron, the olivine volume fraction, the pressure gradient, and the temperature profile, and for the core, its mass and radius. Currently, available geophysical and geochemical knowledge constrains the range of the parameter values. In the present paper, we develop the forward problem and present the governing equations from which synthetic data are computed using a set of parameter values. Among all Martian models fitting the currently available knowledge, we select eight candidate models for which we compute synthetic network science data sets. The synergy between the three geophysical experiments of electromagnetic sounding, geodesy, and seismology is emphasized. The stochastic inversion of the synthetic data sets will be presented in a companion paper.

  9. Congruence analysis of geodetic networks - hypothesis tests versus model selection by information criteria

    Science.gov (United States)

    Lehmann, Rüdiger; Lösler, Michael

    2017-12-01

    Geodetic deformation analysis can be interpreted as a model selection problem. The null model indicates that no deformation has occurred. It is opposed to a number of alternative models, which stipulate different deformation patterns. A common way to select the right model is the usage of a statistical hypothesis test. However, since we have to test a series of deformation patterns, this must be a multiple test. As an alternative solution for the test problem, we propose the p-value approach. Another approach arises from information theory. Here, the Akaike information criterion (AIC) or some alternative is used to select an appropriate model for a given set of observations. Both approaches are discussed and applied to two test scenarios: A synthetic levelling network and the Delft test data set. It is demonstrated that they work but behave differently, sometimes even producing different results. Hypothesis tests are well-established in geodesy, but may suffer from an unfavourable choice of the decision error rates. The multiple test also suffers from statistical dependencies between the test statistics, which are neglected. Both problems are overcome by applying information criterions like AIC.

  10. Characters of Vertical Variability with Geodetic Satellites and Ground-based Continuous GPS in Taiwan

    Science.gov (United States)

    Yang, C.-C.; Wu, Y.-H.; Chao, B. F.; Yu, S.-B.

    2009-04-01

    Present-day GPS network have been extensively used to monitor crustal deformation due to various geodynamic mechanisms. Situated among the Pacific Ring of Fire on the suture zone of Eurasian and Philippine Sea Plates, the island of Taiwan with a dense continuous GPS network since ~1996 and now over 300 stations sees plenty of geophysical phenomena including particularly prominent crustal motions. We assessed daily solution of each station's coordinate time series, and made the routine corrections, such as orbital, EOP, atmospheric and tidal corrections, using GAMIT/GLOBK software (with ITRF05). We then employ the Quasi-Observation Combination Analysis (QOCA) package to obtain the variability and trend after removing occasional earthquake "disruptions". Preliminary results show strong seasonal variations. We then utilize the numerical method of Empirical Orthogonal Function (EOF) to analysis the geophysical signals from the continuous and dense GPS vertical crustal motion observations. We wish to be able to characterize both the seasonal and non-seasonal variability in the vertical crustal motion, in terms of the EOF modes in the spatial domain over Taiwan (plus a few offshore islets) with time evolution spanning the entire period of time. Corraborating with time-variable gravity data from the geodetic satellite mission GRACE, we can further obtain vertical components of both mass-induced loading with respect to the precipitation minus evaporation and the crustal motion caused by the active tectonic processes on Taiwan.

  11. Applications of Voronoi and Delaunay Diagrams in the solution of the geodetic boundary value problem

    Directory of Open Access Journals (Sweden)

    C. A. B. Quintero

    Full Text Available Voronoi and Delaunay structures are presented as discretization tools to be used in numerical surface integration aiming the computation of geodetic problems solutions, when under the integral there is a non-analytical function (e. g., gravity anomaly and height. In the Voronoi approach, the target area is partitioned into polygons which contain the observed point and no interpolation is necessary, only the original data is used. In the Delaunay approach, the observed points are vertices of triangular cells and the value for a cell is interpolated for its barycenter. If the amount and distribution of the observed points are adequate, gridding operation is not required and the numerical surface integration is carried out by point-wise. Even when the amount and distribution of the observed points are not enough, the structures of Voronoi and Delaunay can combine grid with observed points in order to preserve the integrity of the original information. Both schemes are applied to the computation of the Stokes' integral, the terrain correction, the indirect effect and the gradient of the gravity anomaly, in the State of Rio de Janeiro, Brazil area.

  12. Geodetic Measurements and Numerical Models of Deformation at Coso Geothermal Field, California, USA

    Science.gov (United States)

    Ali, S. T.; Reinisch, E. C.; Feigl, K. L.; Davatzes, N. C.

    2016-12-01

    We measure transient deformation at the Coso geothermal field in south-central California using interferometric synthetic aperture data acquired between 2004 and 2016 by the Envisat and Sentinel-1A satellite missions. All well-correlated interferometric pairs show subsidence, with rates as high as 30 mm/year, over a large 75 km2 circular area surrounding the field below which most of the seismicity associated with geothermal production is located. The deformation signature remains in the same location throughout the 12 year interval. Time-series analysis of multiple interferometric pairs reveals continuous subsidence. A decrease in the subsidence rate after 2010 corresponds to a decrease in the net production rate. Using three-dimensional, fully numerical, multiphysics models, we explore the coupling between deformation and geothermal production. We seek to distinguish between two possible mechanisms: (i) decreasing pore-pressure following net extraction of fluids, or (ii) decrease in temperature of presumably fractured reservoir rock. Irrespective of the mechanism, a contracting ellipsoidal reservoir located at a depth of 2 km, with a volume of 80 km3 or less is required to explain the geodetic observations. Almost 90% of the seismicity beneath the field occurs within this 80 km3 ellipsoid.

  13. Geodetic Constraints on the Qinghai-Tibetan Plateau Present-Day Geophysical Processes

    Directory of Open Access Journals (Sweden)

    Kamil Erkan

    2011-01-01

    Full Text Available The Qinghai-Tibetan Plateau is the largest and the highest area in the world with distinct and competing surface and subsurface processes. The entire Plateau has been undergoing crustal deformation and accompanying isostatic uplift as a result of the Cenozoic collision of the Indian and Eurasian continents. Regional secular surface mass changes include the melting of mountain glaciers and ice caps, and permafrost layer degradation due to global warming. There is also a plausible effect of glacial isostatic adjustment due to the removal of a possible Pleistocene ice-sheet. In this article, we present an assessment of the sizes and extents of these competing interior and exterior dynamical processes, and their possible detections using contemporary space geodetic techniques. These techniques include, in addition to GPS, satellite radar altimetry over land, and temporal gravity field measurements from the Gravity Recovery and Climate Experiment (GRACE satellite mission. These techniques are complementary: land satellite altimetry, similar to GPS, is sensitive only to surface uplift, whereas GRACE is sensitive to both surface uplift and mass changes inside the Earth. Each process may dominate the others in a particular region. Our analysis shows that GRACE data are more sensitive (than GPS or land altimetry to hydrologic and meteorology signals, some of which are larger than the combined effect of geodynamic processes and permafrost degradation.

  14. Development of AN Open-Source Automatic Deformation Monitoring System for Geodetical and Geotechnical Measurements

    Science.gov (United States)

    Engel, P.; Schweimler, B.

    2016-04-01

    The deformation monitoring of structures and buildings is an important task field of modern engineering surveying, ensuring the standing and reliability of supervised objects over a long period. Several commercial hardware and software solutions for the realization of such monitoring measurements are available on the market. In addition to them, a research team at the Neubrandenburg University of Applied Sciences (NUAS) is actively developing a software package for monitoring purposes in geodesy and geotechnics, which is distributed under an open source licence and free of charge. The task of managing an open source project is well-known in computer science, but it is fairly new in a geodetic context. This paper contributes to that issue by detailing applications, frameworks, and interfaces for the design and implementation of open hardware and software solutions for sensor control, sensor networks, and data management in automatic deformation monitoring. It will be discussed how the development effort of networked applications can be reduced by using free programming tools, cloud computing technologies, and rapid prototyping methods.

  15. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.

    1959-01-01

    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  16. Myocardial adaption to HI(RT in previously untrained men with a randomized, longitudinal cardiac MR imaging study (Physical adaptions in Untrained on Strength and Heart trial, PUSH-trial.

    Directory of Open Access Journals (Sweden)

    Michael Scharf

    Full Text Available Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance training (HI(RT induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI study.80 untrained middle-aged men were randomly assigned to a HI(RT-group (n = 40; 43.5±5.9 years or an inactive control group (n = 40; 42.0±6.3 years. HI(RT comprised 22 weeks of training focusing on a single-set to failure protocol in 2-3 sessions/week, each with 10-13 exercises addressing main muscle groups. Repetitions were decreased from 8-10 to 3-5 during study period. Before and after HI(RT all subjects underwent physiologic examination and cardiac MRI (cine imaging, tagging.Indexed left (LV and right ventricular (RV volume (LV: 76.8±15.6 to 78.7±14.8 ml/m2; RV: 77.0±15.5 to 78.7±15.1 ml/m2 and mass (LV: 55.5±9.7 to 57.0±8.8 g/m2; RV: 14.6±3.0 to 15.0±2.9 g/m2 significantly increased with HI(RT (all p<0.001. Mean LV and RV remodeling indices of HI(RT-group did not alter with training (0.73g/mL and 0.19g/mL, respectively [p = 0.96 and p = 0.87], indicating balanced cardiac adaption. Indexed LV (48.4±11.1 to 50.8±11.0 ml/m2 and RV (48.5±11.0 to 50.6±10.7 ml/m2 stroke volume significantly increased with HI(RT (p<0.001. Myocardial strain and strain rates did not change following resistance exercise. Left atrial volume at end systole slightly increased after HI(RT (36.2±7.9 to 37.0±8.4 ml/m2, p = 0.411, the ratio to end-diastolic LV volume at baseline and post-training was unchanged (0.47 vs. 0.47, p = 0.79.22 weeks of HI(RT lead to measurable, physiological changes in cardiac atrial and ventricular morphologic characteristics and function in previously untrained men.The PUSH-trial is registered at the US National Institutes of Health

  17. Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

    Science.gov (United States)

    Leonard, John P; Kolibaba, Kathryn S; Reeves, James A; Tulpule, Anil; Flinn, Ian W; Kolevska, Tatjana; Robles, Robert; Flowers, Christopher R; Collins, Robert; DiBella, Nicholas J; Papish, Steven W; Venugopal, Parameswaran; Horodner, Andrew; Tabatabai, Amir; Hajdenberg, Julio; Park, Jaehong; Neuwirth, Rachel; Mulligan, George; Suryanarayan, Kaveri; Esseltine, Dixie-Lee; de Vos, Sven

    2017-11-01

    Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL). Patients and Methods After real-time determination of non-GCB DLBCL using the Hans immunohistochemistry algorithm, 206 patients were randomly assigned (1:1; stratified by International Prognostic Index [IPI] score) to six 21-day cycles of standard R-CHOP alone or R-CHOP plus bortezomib 1.3 mg/m 2 intravenously on days 1 and 4 (VR-CHOP). The primary end point, progression-free survival (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or more doses of study drug (91 R-CHOP, 92 VR-CHOP). Results After a median follow-up of 34 months, with 25% (R-CHOP) and 18% (VR-CHOP) of patients having had PFS events, the hazard ratio (HR) for PFS was 0.73 (90% CI, 0.43 to 1.24) with VR-CHOP ( P = .611). Two-year PFS rates were 77.6% with R-CHOP and 82.0% with VR-CHOP; they were 65.1% versus 72.4% in patients with high-intermediate/high IPI (HR, 0.67; 90% CI, 0.34 to 1.29), and 90.0% versus 88.9% (HR, 0.85; 90% CI, 0.35 to 2.10) in patients with low/low-intermediate IPI. Overall response rate with R-CHOP and VR-CHOP was 98% and 96%, respectively. The overall survival HR was 0.75 (90% CI, 0.38 to 1.45); 2-year survival rates were 88.4% and 93.0%, respectively. In the safety population (100 R-CHOP and 101 VR-CHOP patients), grade ≥ 3 adverse events included neutropenia (53% v 49%), thrombocytopenia (13% v 29%), anemia (7% v 15%), leukopenia (26% v 25%), and neuropathy (1% v 5%). Conclusion Outcomes for newly diagnosed, prospectively enrolled patients with non-GCB DLBCL were more favorable than expected with R-CHOP and were not significantly improved by adding bortezomib.

  18. Management of choledocholithiasis after previous gastrectomy.

    Science.gov (United States)

    Anwer, S; Egan, R; Cross, N; Guru Naidu, S; Somasekar, K

    2017-09-01

    Common bile duct stones in patients with a previous gastrectomy can be a technical challenge because of the altered anatomy. This paper presents the successful management of two such patients using non-traditional techniques as conventional endoscopic retrograde cholangiopancreatography was not possible.

  19. GPS/acoustic seafloor geodetic observation in the subduction zone around Japan (Invited)

    Science.gov (United States)

    Sato, M.; Kido, M.; Tadokoro, K.; Fujimoto, H.

    2013-12-01

    GPS/acoustic (GPS/A) seafloor geodetic observation is a precise seafloor positioning technique and has made great progress over the last decade. GPS/A observation determines the positions of acoustic mirror-type transponders installed on the seafloor by combining the two techniques of kinematic GPS and acoustic ranging through a ship or a buoy. The original idea was proposed by Prof. Spiess at the Scripps Institution of Oceanography in 1985 and its protocol and hardware were made through research and development of his group by the mid-1990s. In Japan, three research groups, Japan Coast Guard, Tohoku University and Nagoya University, began to develop the GPS/A observation system in the 1990s, established GPS/A observation sites mainly on the landward slope of the plate boundaries around Japan, such as the Japan Trench and the Nankai trough, and have been carrying out campaign observations since around 2000. The primary purpose of our observation is to detect and monitor the crustal deformation caused by the subduction of the oceanic plate near the plate boundary where large interplate earthquakes have repeatedly occurred. By continuous efforts for over a decade, the positioning precision has achieved a few centimeters and seafloor movements such as intraplate deformation and coseismic displacements have been successfully detected. In particular, regarding the 2011 Tohoku-oki earthquake (M9.0), which occurred off northeastern Japan on March 11, 2011, east-southeastward coseismic displacements of up to 31 m were observed above the focal region, especially close to the epicenter, while those detected by on-land GPS measurements over 100 km away from the epicenter, conducted by the Geospatial Information Authority of Japan, was up to 5.3 m. Coseismic slip models on the plate boundary estimated from not only GPS data but also GPS/A results indicate that a huge slip of more than 50 m generated close to the trench axis, which was much larger than that estimated from GPS

  20. Evaluation of a New Prototype Geodetic Astrolabe for Measuring Deflections of the Vertical

    Science.gov (United States)

    Slater, J. A.; Thompson, N.; Angell, L. E.; Belenkii, M. S.; Bruns, D. G.; Johnson, D. O.

    2009-12-01

    During the last three years, the National Geospatial-Intelligence Agency (NGA), with assistance from the U.S. Naval Observatory (USNO), sponsored the development of a new electronic geodetic astrolabe for measuring deflections of the vertical (DoV). NGA’s current operational astrolabes, built in 1995, have a number of undesirable features including the need for a pool of liquid mercury as a reflecting surface. The new state-of-the-art prototype instrument, completed by Trex Enterprises in early 2009, was designed to meet a 0.2 arcsec accuracy requirement. It reduces the weight, eliminates the mercury, and dramatically reduces observation times. The new astrolabe consists of a 101 mm aperture telescope with a 1.5° field of view and an inclinometer mounted inside a 92-cm high, 30-cm diameter tube, an external GPS receiver for timing, and a laptop computer that controls and monitors the instrument and performs the computations. Star images are recorded by an astronomical-grade camera with a 2,048 x 2,048 pixel CCD sensor that is externally triggered by time pulses from the GPS receiver. The prototype was designed for nighttime observation of visible stars equal to or brighter than magnitude 10.0. The inclinometer is a system of two orthogonal pendula that define the local gravitational vertical, each consisting of a brass plumb bob suspended from an aluminized polymer ribbon set between two electrodes. An internal reference collimator is rigidly tied to the inclinometer and projects an array of reference points of light onto the CCD sensor. After the astrolabe is coarsely leveled to within 20 arcsec, voice coil actuators automatically adjust and maintain the inclinometer vertical to within 0.02 arcsec. Independent images are collected at 6 second intervals using a 200 msec exposure time. The CCD coordinates are determined for each star and a collimator reference point on each image. Stars are identified by referencing a customized star catalog produced by USNO. A

  1. Geodetic mass balance measurements on debris and clean-ice tropical glaciers in Ecuador

    Science.gov (United States)

    La Frenierre, J.; Decker, C. R.; Jordan, E.; Wigmore, O.; Hodge, B. E.; Niederriter, C.; Michels, A.

    2017-12-01

    Glaciers are recognized as highly sensitive indicators of climate change in high altitude, low latitude environments. In the tropical Andes, various analyses of glacier surface area change have helped illuminate the manifestation of climate change in this region, however, information about actual glacier mass balance behavior is much more limited given the relatively small glaciers, difficult access, poor weather, and/or limited local resources common here. Several new technologies, including aerial and terrestrial LIDAR and structure-from-motion photogrammetry using small unmanned aerial vehicles (UAVs), make mass balance measurements using geodetic approaches increasingly feasible in remote mountain locations, which can both further our understanding of changing climatic conditions, and improve our ability to evaluate the downstream hydrologic impacts of ice loss. At Volcán Chimborazo, Ecuador, these new technologies, combined with a unique, 5-meter resolution digital elevation model derived from 1997 aerial imagery, make possible an analysis of the magnitude and spatial patterns of mass balance behavior over the past two decades. Here, we evaluate ice loss between 1997 and 2017 at the tongues of two adjacent glaciers, one debris-covered and detached from its accumulation area (Reschreiter Glacier), and one debris-free and intact (Hans Meyer Glacier). Additionally, we incorporate data from 2012 and 2013 terrestrial LIDAR surveys to evaluate the behavior of the Reschreiter at a finer temporal resolution. We find that on the Hans Meyer, the mean surface deflation rate since 1997 at the present-day tongue has been nearly 3 m yr-1, while on the lower-elevation Reschreiter, the mean deflation rate has been approximately 1 m yr-1. However, the processes by which debris-covered ice becomes exposed results in highly heterogeneous patterns of ice loss, with some areas experiencing surface deflation rates approaching 15 m yr-1 when energy absorption is unimpeded.

  2. Geodetic integration of Sentinel-1A IW data using PSInSAR in Hungary

    Science.gov (United States)

    Farkas, Péter; Hevér, Renáta; Grenerczy, Gyula

    2015-04-01

    ESA's latest Synthetic Aperture Radar (SAR) mission Sentinel-1 is a huge step forward in SAR interferometry. With its default acquisition mode called the Interferometric Wide Swath Mode (IW) areas through all scales can be mapped with an excellent return time of 12 days (while only the Sentinel-1A is in orbit). Its operational data policy is also a novelty, it allows scientific users free and unlimited access to data. It implements a new type of ScanSAR mode called Terrain Observation with Progressive Scan (TOPS) SAR. It has the same resolution as ScanSAR but with better signal-to-noise ratio distribution. The bigger coverage is achieved by rotation of the antenna in the azimuth direction, therefore it requires very precise co-registration because even errors under a pixel accuracy can introduce azimuth phase variations caused by differences in Doppler-centroids. In our work we will summarize the benefits and the drawbacks of the IW mode. We would like to implement the processing chain of GAMMA Remote Sensing of such data for mapping surface motion with special attention to the co-registration step. Not only traditional InSAR but the advanced method of Persistent Scatterer InSAR (PSInSAR) will be performed and presented as well. PS coverage, along with coherence, is expected to be good due to the small perpendicular and temporal baselines. We would also like to integrate these measurements into national geodetic networks using common reference points. We have installed trihedral corner reflectors at some selected sites to aid precise collocation. Thus, we aim to demonstrate that Sentinel-1 can be effectively used for surface movement detection and monitoring and it can also provide valuable information for the improvement of our networks.

  3. Observing active deformation of volcanoes in North America: Geodetic data from the Plate Boundary Observatory and associated networks

    Science.gov (United States)

    Puskas, C. M.; Phillips, D. A.; Mattioli, G. S.; Meertens, C. M.; Hodgkinson, K. M.; Crosby, C. J.; Enders, M.; Feaux, K.; Mencin, D.; Baker, S.; Lisowski, M.; Smith, R. B.

    2013-12-01

    The EarthScope Plate Boundary Observatory (PBO), operated by UNAVCO, records deformation of the geologically diverse North America western plate boundary, with subnetworks of instruments concentrated at selected active and potentially active volcanoes. These sensors record deformation and earthquakes and allow monitoring agencies and researchers to analyze changes in ground motion and seismicity. The intraplate volcanoes at Yellowstone and Long Valley are characterized by uplift/subsidence cycles, high seismicity, and hydrothermal activity but there have been no historic eruptions at either volcano. PBO maintains dense GPS networks of 20-25 stations at each of these volcanoes, with an additional 5 boreholes at Yellowstone containing tensor strainmeters, short-period seismometers, and borehole tiltmeters. Subduction zone volcanoes in the Aleutian Arc have had multiple historic eruptions, and PBO maintains equipment at Augustine (8 GPS), Akutan (8 GPS, 4 tiltmeters), and Unimak Island (14 GPS, 8 tiltmeters). The Unimak stations are at the active Westdahl and Shishaldin edifices and the nearby, inactive Isanotski volcano. In the Cascade Arc, PBO maintains networks at Mount St. Helens (15 GPS, 4 borehole strainmeters and seismometers, 8 borehole tiltmeters), Shasta (7 GPS, 1 borehole strainmeter and seismometer), and Lassen Peak (8 GPS). Data from many of these stations in the Pacific Northwest and California are also provided as realtime streams of raw and processed data. Real-time GPS data, along with high-rate GPS data, will be an important new resource for detecting and studying future rapid volcanic deformation events and earthquakes. UNAVCO works closely with the USGS Volcano Hazards Program, archiving data from USGS GPS stations in Alaska, Cascadia, and Long Valley. The PBO and USGS networks combined provide more comprehensive coverage than PBO alone, particularly of the Cascade Arc, where the USGS maintains a multiple instruments near each volcano. Ground

  4. Explaining the current geodetic field with geological models: A case study of the Haiyuan fault system

    Science.gov (United States)

    Daout, S.; Jolivet, R.; Lasserre, C.; Doin, M. P.; Barbot, S.; Peltzer, G.; Tapponnier, P.

    2015-12-01

    Oblique convergence across Tibet leads to slip partitioning with the co-existence of strike-slip, normal and thrust motion in major fault systems. While such complexity has been shown at the surface, the question is to understand how faults interact and accumulate strain at depth. Here, we process InSAR data across the central Haiyuan restraining bend, at the north-eastern boundary of the Tibetan plateau and show that the surface complexity can be explained by partitioning of a uniform deep-seated convergence rate. We construct a time series of ground deformation, from Envisat radar data spanning from 2001-2011 period, across a challenging area because of the high jump in topography between the desert environment and the plateau. To improve the signal-to-noise ratio, we used the latest Synthetic Aperture Radar interferometry methodology, such as Global Atmospheric Models (ERA Interim) and Digital Elevation Model errors corrections before unwrapping. We then developed a new Bayesian approach, jointly inverting our InSAR time series together with published GPS displacements. We explore fault system geometry at depth and associated slip rates and determine a uniform N86±7E° convergence rate of 8.45±1.4 mm/yr across the whole fault system with a variable partitioning west and east of a major extensional fault-jog. Our 2D model gives a quantitative understanding of how crustal deformation is accumulated by the various branches of this thrust/strike-slip fault system and demonstrate the importance of the geometry of the Haiyuan Fault, controlling the partitioning or the extrusion of the block motion. The approach we have developed would allow constraining the low strain accumulation along deep faults, like for example for the blind thrust faults or possible detachment in the San Andreas "big bend", which are often associated to a poorly understood seismic hazard.

  5. Previously unknown organomagnesium compounds in astrochemical context

    OpenAIRE

    Ruf, Alexander

    2018-01-01

    We describe the detection of dihydroxymagnesium carboxylates (CHOMg) in astrochemical context. CHOMg was detected in meteorites via ultrahigh-resolving chemical analytics and represents a novel, previously unreported chemical class. Thus, chemical stability was probed via quantum chemical computations, in combination with experimental fragmentation techniques. Results propose the putative formation of green-chemical OH-Grignard-type molecules and triggered fundamental questions within chemica...

  6. Implant breast reconstruction after salvage mastectomy in previously irradiated patients.

    Science.gov (United States)

    Persichetti, Paolo; Cagli, Barbara; Simone, Pierfranco; Cogliandro, Annalisa; Fortunato, Lucio; Altomare, Vittorio; Trodella, Lucio

    2009-04-01

    The most common surgical approach in case of local tumor recurrence after quadrantectomy and radiotherapy is salvage mastectomy. Breast reconstruction is the subsequent phase of the treatment and the plastic surgeon has to operate on previously irradiated and manipulated tissues. The medical literature highlights that breast reconstruction with tissue expanders is not a pursuable option, considering previous radiotherapy a contraindication. The purpose of this retrospective study is to evaluate the influence of previous radiotherapy on 2-stage breast reconstruction (tissue expander/implant). Only patients with analogous timing of radiation therapy and the same demolitive and reconstructive procedures were recruited. The results of this study prove that, after salvage mastectomy in previously irradiated patients, implant reconstruction is still possible. Further comparative studies are, of course, advisable to draw any conclusion on the possibility to perform implant reconstruction in previously irradiated patients.

  7. Repeat Targeted Prostate Biopsy under Guidance of Multiparametric MRI-Correlated Real-Time Contrast-Enhanced Ultrasound for Patients with Previous Negative Biopsy and Elevated Prostate-Specific Antigen: A Prospective Study

    OpenAIRE

    Jang, Dong Ryul; Jung, Dae Chul; Oh, Young Taik; Noh, Songmi; Han, Kyunghwa; Kim, Kiwook; Rha, Koon-Ho; Choi, Young Deuk; Hong, Sung Joon

    2015-01-01

    Objectives To prospectively determine whether multi-parametric MRI (mpMRI) - contrast-enhanced ultrasound (CEUS) correlated, imaging-guided target biopsy (TB) method could improve the detection of prostate cancer in re-biopsy setting of patients with prior negative biopsy. Methods From 2012 to 2014, a total of 42 Korean men with a negative result from previous systematic biopsy (SB) and elevated prostate-specific antigen underwent 3T mpMRI and real-time CEUS guided TB. Target lesions were det...

  8. Influence of the physico-chemical process as previous treatment to the electrocoagulation. Study with leachate of a landfill; Influencia del proceso fisicoquimico como tratamiento previo a la electrocoagulacion. Estudio con lixiviados de un relleno

    Energy Technology Data Exchange (ETDEWEB)

    Mercado Martinez, I. D.; Reyes Avila, D.

    2007-07-01

    This article has as purpose to show the influence of the method physico-chemical as previous process to the novel technique of electrocoagulation, presenting as a new alternative to depurate wastewaters. to obtain it, was done tests measuring the very parameters to leachates so much affluent as effluent from treatment plant of the Sanitary Landfill La Esmeralda, situated near to the Manizales city(Colombia), and so much before as later to apply this electrochemical technology, looking for this way to compare the obtained removals. (Author)

  9. Combined Summary Paper: -Current and Future Geodetic Satellite Missions for Global Change Monitoring - On the Capacity of Swarm for Surface Mass Variation Monitoring: Quantitative Assessment Based on Orbit Information from CHAMP, GRACE and GOCE - The Lake Level Variations in China from Satellite Altimetric Data

    Science.gov (United States)

    Sneeuw, N.; Li, J.; Baur, O.; Cai, J.; Tourian, M. J.; Elmi, O.; Jiang, W.; Chu, Y.; Jin, T.; Wirnsberger, H.; Krauss, S.; Maier, A.

    2014-11-01

    Global change deals with large- and small-scale processes that modify the Earth's atmosphere, land and ocean. Using innovative geodetic space-borne sensor systems, dedicated gravity field and altimeter satellites monitor these processes over a range of spatial and temporal scales. The integrated analysis of these geometric and gravimetric Earth observation data shall improve the knowledge of system processes of the changing Earth. A few case studies elucidate the role of satellite geodesy in Earth system science.

  10. Surface deformation associated with the 2015 Mw 8.3 Illapel earthquake revealed by satellite-based geodetic observations and its implications for the seismic cycle

    Science.gov (United States)

    Feng, Wanpeng; Samsonov, Sergey; Tian, Yunfeng; Qiu, Qiang; Li, Peng; Zhang, Yong; Deng, Zhiguo; Omari, Khalid

    2017-02-01

    In this study, we present inter-, co- and post-seismic displacements observed in the 2015 Illapel earthquake area by Global Positioning System (GPS) and Synthetic Aperture Radar Interferometry (InSAR). RADARSAT-2, ALOS-2 and Sentinel-1A interferograms capture the co- and post-seismic displacements due to the Illapel earthquake. Based on a layered Earth structure, we modeled both co- and post-seismic faulting behaviors on the subduction interface of central Chile. The best-fit model shows that the coseismic rupture broke a 200 km × 200 km area with a maximum slip of 10 m at a depth of 20 km. Two distinct slip centers, likely controlled by local ramp-flat structure, are revealed. The total coseismic geodetic moment is 2.76 ×1021 N m, equivalent to a moment magnitude 8.3. The accumulated afterslip in the first two months after the mainshock is observed on both sides of the coseismic rupture zone with both ascending and descending Sentinel-1A interferograms. A limited overlap zone between co- and post-seismic slip models can be observed, suggesting partitioning of the frictional properties within the Illapel earthquake rupture zone. The total afterslip releases ∼ 5.0 ×1020 N m geodetic moment, which is equivalent to an earthquake of Mw 7.7. The 2010 Mw 8.8 Maule earthquake that occurred ∼400 km away from the Illapel earthquake epicenter could have exerted certain effects on the seismic cycle of the Illapel earthquake area. The seismic records from 2000 to 2015 imply that the rate of annual seismic moment release in the Illapel earthquake area dropped from 0.4 to 0.2 ×1019 N m /yr after the Maule earthquake. Based on the forward modeling with the best-fit slip models determined in this study, we reproduce the local surface displacements before, during and after the Illapel earthquake. A rough deformation cycle, 105 ± 29 yr, calculated by using the coseismic displacements and interseismic rate is basically identical with the revisit interval of M8 events in the

  11. Incorporating Geodetic Technologies in to Field and Campus Courses at the University of Michigan: Best Practices and Lessons Learned

    Science.gov (United States)

    Niemi, N. A.; Clark, M. K.

    2017-12-01

    For the past 6 years, the University of Michigan has implemented geodetic techniques into both summer field courses and on-campus courses. The primary means for incorporating these technologies has been a partnership with UNAVCO to introduce terrestrial laser scanning (TLS) at summer field courses, although employing Structure from Motion(SfM), ArcCollector for iPads and RTK GPS surveying have also been explored. The nature of these types of data lend themselves readily to geomorphology, environmental, and natural hazards-based projects, and we have developed field projects or labs around neotectonics (fault-scarp scanning and diffusion analysis), change detection (braided stream evolution, landslide and rock glacier motion, coastal change) and mass wasting processes (rock avalanche scanning and analysis). While we have primarily developed multi-day projects that use these tools in a field camp setting, we have also developed weekend field trip projects and traditional afternoon lab exercises associated with on-campus courses. The use of geodetic technology is generally well received by students. Reasons for this are the use of somewhat different skill sets from traditional geologic mapping problems, including research survey design, real-time data acquisition, and quantitative data analysis. Students also perceive that they are engaged in learning technology which they may use in their future employment. Challenges encountered, particularly in the field, include managing large student groups with a finite pool of equipment, rapid data processing pressures, variable student experience with analysis software and limited technical support for field-based computational resources. We will describe the positive attributes of incorporating geodetic technologies into undergraduate courses and elaborate on some best practices learned from our experiences.

  12. Using geodetic data to infer the kinematic and mechanical properties of deformation sources on Kilauea Volcano, Hawaii

    Science.gov (United States)

    Cervelli, Peter Francis

    2002-09-01

    Paradoxically, one of the greatest hazards associated with oceanic volcanoes is not volcanic. Rather, it is the potential for catastrophic flank failure resulting in devastating tsunamis, which threaten not just the immediate vicinity, but coastal cities along the entire rim of an ocean basin. Kilauea volcano on the Island of Hawaii, USA, a potential source of such flank failures, is monitored by a network of continuously recording geodetic instruments, including Global Positioning System (GPS) receivers, tiltmeters, and strainmeters. In this thesis, methodology is developed for using these geodetic data to estimate the geometry and type of active deformation sources, such as dikes, magma chambers, and faults. The methodology is then applied to two episodes of deformation that occurred at Kilauea Volcano in 1999 and 2000. First, the deformation associated with an earthquake swarm on September 12, 1999 in the Upper East Rift Zone of Kilauea Volcano, which was recorded by continuous GPS receivers, tiltmeters, campaign GPS, leveling, and InSAR, is analyzed and interpreted as a west to east propagating dike intrusion. Lack of premonitory inflation of Kilauea's summit suggests that the immediate cause of the intrusion was probably tensile failure in the shallow crust of the Upper East Rift, rather than forceful magma injection. Second, in early November 2000, the geodetic network recorded transient southeastward displacements, which we interpret as an episode of aseismic fault slip. The duration of the event was about 36 hours; it had an equivalent moment magnitude of M5.7, and a maximum slip velocity of about 6 cm/day. Inversion of the GPS data images a shallowly dipping thrust at a depth of 4.5 km that we interpret as the down dip extension of the Hilina Pali fault system. Thus it is demonstrated that continuous geodetic networks can detect accelerating slip, potentially leading to warnings of imminent volcanic flank collapse. Finally, in the last chapter of the

  13. Upgrading the seismic and geodetic network of the Popocatépetl volcano (Mexico).

    Science.gov (United States)

    Calò, Marco; Iglesias Mendoza, Arturo; Legrand, Denis; Valdés González, Carlos Miguel; Perez Campos, Xyoli

    2017-04-01

    The Popocatépetl is one of the most active volcanoes in Mexico and is located only 70 km from Mexico City, populated by more than 20 millions of people, and only 35 km from the Puebla municipality with almost 1.5 millions of people living. The recent activity of the volcano is generally marked by explosions emitting ash plumes often reaching the densely populated regions. In the framework of the Mexican Fund for Prevention of Natural Disasters (FOPREDEN) we are renovating and upgrading the existing geodetic and seismic networks monitoring the volcano. In this project we are installing 10 broadband seismic stations (120s-050Hz) in shallow boreholes (3-5m depth) and 4 GPS with real time sampling rate of 1 Hz. All instruments are equipped with continuous recording systems for real time monitoring purposes and research. The Popocatépetl exceeds 5400m, and the altitude of the stations ranges from 2200 m to 4300 m making it difficult their installation and maintenance. Because of ash emissions and the hard working condition, the real-time transmission is split into two systems in order to ensure the monitoring of the volcano also during the highest expected activity. Therefore we set up a network of "first order", consisting of four stations located about 20 km from the crater and equipped with satellite transmission. These stations, being far enough from the crater, ensure the real time monitoring of the major events also during intense periods of activity of the volcano. The remaining six stations are installed near to the crater (less than 10 km) and take part of the "second order" network equipped with a telemetered radio system transmitting the data either directly to the National Center of Disaster Prevention (CENAPRED) and National Seismological Service (SSN) or to the first order stations (for the sites that have not direct visible line with the monitoring centers). The four GPS sensors are all installed in the second order sites in order to monitor the largest

  14. Immersive Virtual Reality Field Trips in the Geosciences: Integrating Geodetic Data in Undergraduate Geoscience Courses

    Science.gov (United States)

    La Femina, P. C.; Klippel, A.; Zhao, J.; Walgruen, J. O.; Stubbs, C.; Jackson, K. L.; Wetzel, R.

    2017-12-01

    High-quality geodetic data and data products, including GPS-GNSS, InSAR, LiDAR, and Structure from Motion (SfM) are opening the doors to visualizing, quantifying, and modeling geologic, tectonic, geomorphic, and geodynamic processes. The integration of these data sets with other geophysical, geochemical and geologic data is providing opportunities for the development of immersive Virtual Reality (iVR) field trips in the geosciences. iVR fieldtrips increase accessibility in the geosciences, by providing experiences that allow for: 1) exploration of field locations that might not be tenable for introductory or majors courses; 2) accessibility to outcrops for students with physical disabilities; and 3) the development of online geosciences courses. We have developed a workflow for producing iVR fieldtrips and tools to make quantitative observations (e.g., distance, area, and volume) within the iVR environment. We use a combination of terrestrial LiDAR and SfM data, 360° photos and videos, and other geophysical, geochemical and geologic data to develop realistic experiences for students to be exposed to the geosciences from sedimentary geology to physical volcanology. We present two of our iVR field trips: 1) Inside the Volcano: Exploring monogenetic volcanism at Thrihnukagigar Iceland; and 2) Changes in Depositional Environment in a Sedimentary Sequence: The Reedsville and Bald Eagle Formations, Pennsylvania. The Thrihnukagigar experience provides the opportunity to investigate monogenetic volcanism through the exploration of the upper 125 m of a fissure-cinder cone eruptive system. Students start at the plate boundary scale, then zoom into a single volcano where they can view the 3D geometry from either terrestrial LiDAR or SfM point clouds, view geochemical data and petrologic thins sections of rock samples, and a presentation of data collection and analysis, results and interpretation. Our sedimentary geology experience is based on a field lab from our

  15. An accuracy assessment of realtime GNSS time series toward semi- real time seafloor geodetic observation

    Science.gov (United States)

    Osada, Y.; Ohta, Y.; Demachi, T.; Kido, M.; Fujimoto, H.; Azuma, R.; Hino, R.

    2013-12-01

    Large interplate earthquake repeatedly occurred in Japan Trench. Recently, the detail crustal deformation revealed by the nation-wide inland GPS network called as GEONET by GSI. However, the maximum displacement region for interplate earthquake is mainly located offshore region. GPS/Acoustic seafloor geodetic observation (hereafter GPS/A) is quite important and useful for understanding of shallower part of the interplate coupling between subducting and overriding plates. We typically conduct GPS/A in specific ocean area based on repeated campaign style using research vessel or buoy. Therefore, we cannot monitor the temporal variation of seafloor crustal deformation in real time. The one of technical issue on real time observation is kinematic GPS analysis because kinematic GPS analysis based on reference and rover data. If the precise kinematic GPS analysis will be possible in the offshore region, it should be promising method for real time GPS/A with USV (Unmanned Surface Vehicle) and a moored buoy. We assessed stability, precision and accuracy of StarFireTM global satellites based augmentation system. We primarily tested for StarFire in the static condition. In order to assess coordinate precision and accuracy, we compared 1Hz StarFire time series and post-processed precise point positioning (PPP) 1Hz time series by GIPSY-OASIS II processing software Ver. 6.1.2 with three difference product types (ultra-rapid, rapid, and final orbits). We also used difference interval clock information (30 and 300 seconds) for the post-processed PPP processing. The standard deviation of real time StarFire time series is less than 30 mm (horizontal components) and 60 mm (vertical component) based on 1 month continuous processing. We also assessed noise spectrum of the estimated time series by StarFire and post-processed GIPSY PPP results. We found that the noise spectrum of StarFire time series is similar pattern with GIPSY-OASIS II processing result based on JPL rapid orbit

  16. A Unified Geodetic Vertical Velocity Field (UGVVF), Version 1.0

    Science.gov (United States)

    Schmalzle, G.; Wdowinski, S.

    2014-12-01

    Tectonic motion, volcanic inflation or deflation, as well as oil, gas and water pumping can induce vertical motion. In southern California these signals are inter-mingled. In tectonics, properly identifying regions that are contaminated by other signals can be important when estimating fault slip rates. Until recently vertical deformation rates determined by high precision Global Positioning Systems (GPS) had large uncertainties compared to horizontal components and were rarely used to constrain tectonic models of fault motion. However, many continuously occupied GPS stations have been operating for ten or more years, often delivering uncertainties of ~1 mm/yr or less, providing better constraints for tectonic modeling. Various processing centers produced GPS time series and estimated vertical velocity fields, each with their own set of processing techniques and assumptions. We compare vertical velocity solutions estimated by seven data processing groups as well as two combined solutions (Figure 1). These groups include: Central Washington University (CWU) and New Mexico Institute of Technology (NMT), and their combined solution provided by the Plate Boundary Observatory (PBO) through the UNAVCO website. Also compared are the Jet Propulsion Laboratory (JPL) and Scripps Orbit and Permanent Array Center (SOPAC) and their combined solution provided as part of the NASA MEaSUREs project. Smaller velocity fields included are from Amos et al., 2014, processed at the Nevada Geodetic Laboratory, Shen et al., 2011, processed by UCLA and called the Crustal Motion Map 4.0 (CMM4) dataset, and a new velocity field provided by the University of Miami (UM). Our analysis includes estimating and correcting for systematic vertical velocity and uncertainty differences between groups. Our final product is a unified velocity field that contains the median values of the adjusted velocity fields and their uncertainties. This product will be periodically updated when new velocity fields

  17. The Geodetic Seamless Archive Centers Service Layer: A System Architecture for Federating Geodesy Data Repositories

    Science.gov (United States)

    McWhirter, J.; Boler, F. M.; Bock, Y.; Jamason, P.; Squibb, M. B.; Noll, C. E.; Blewitt, G.; Kreemer, C. W.

    2010-12-01

    Three geodesy Archive Centers, Scripps Orbit and Permanent Array Center (SOPAC), NASA's Crustal Dynamics Data Information System (CDDIS) and UNAVCO are engaged in a joint effort to define and develop a common Web Service Application Programming Interface (API) for accessing geodetic data holdings. This effort is funded by the NASA ROSES ACCESS Program to modernize the original GPS Seamless Archive Centers (GSAC) technology which was developed in the 1990s. A new web service interface, the GSAC-WS, is being developed to provide uniform and expanded mechanisms through which users can access our data repositories. In total, our respective archives hold tens of millions of files and contain a rich collection of site/station metadata. Though we serve similar user communities, we currently provide a range of different access methods, query services and metadata formats. This leads to a lack of consistency in the userís experience and a duplication of engineering efforts. The GSAC-WS API and its reference implementation in an underlying Java-based GSAC Service Layer (GSL) supports metadata and data queries into site/station oriented data archives. The general nature of this API makes it applicable to a broad range of data systems. The overall goals of this project include providing consistent and rich query interfaces for end users and client programs, the development of enabling technology to facilitate third party repositories in developing these web service capabilities and to enable the ability to perform data queries across a collection of federated GSAC-WS enabled repositories. A fundamental challenge faced in this project is to provide a common suite of query services across a heterogeneous collection of data yet enabling each repository to expose their specific metadata holdings. To address this challenge we are developing a "capabilities" based service where a repository can describe its specific query and metadata capabilities. Furthermore, the architecture of

  18. Books average previous decade of economic misery.

    Science.gov (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  19. No discrimination against previous mates in a sexually cannibalistic spider

    Science.gov (United States)

    Fromhage, Lutz; Schneider, Jutta M.

    2005-09-01

    In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.

  20. Delivery outcomes at term after one previous cesarean section.

    Science.gov (United States)

    Yamani-Zamzami, Tarik Y

    2007-12-01

    To determine the maternal and perinatal outcomes at term in women with one previous cesarean delivery and with no history of vaginal birth. This is a case-control study conducted at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, between January 1, 1999 and December 31, 2002. One hundred sixty-two women with one previous cesarean delivery and with no previous vaginal birth were compared with 324 control women. The cesarean section rate was higher in the study group 40 (24.7%) versus 23 (7.1%) in the control group and was statistically significant (phistory of vaginal delivery are considered less favorable, the vaginal birth after cesarean section success rate may be even lower if the indication for previous primary cesarean delivery was failure to progress, and may be associated with increased risk of uterine rupture. Further study is required to confirm our findings.

  1. A Comparison of Geodetic and Geologic Rates Prior to Large Strike-Slip Earthquakes: A Diversity of Earthquake-Cycle Behaviors?

    Science.gov (United States)

    Dolan, James F.; Meade, Brendan J.

    2017-12-01

    Comparison of preevent geodetic and geologic rates in three large-magnitude (Mw = 7.6-7.9) strike-slip earthquakes reveals a wide range of behaviors. Specifically, geodetic rates of 26-28 mm/yr for the North Anatolian fault along the 1999 MW = 7.6 Izmit rupture are ˜40% faster than Holocene geologic rates. In contrast, geodetic rates of ˜6-8 mm/yr along the Denali fault prior to the 2002 MW = 7.9 Denali earthquake are only approximately half as fast as the latest Pleistocene-Holocene geologic rate of ˜12 mm/yr. In the third example where a sufficiently long pre-earthquake geodetic time series exists, the geodetic and geologic rates along the 2001 MW = 7.8 Kokoxili rupture on the Kunlun fault are approximately equal at ˜11 mm/yr. These results are not readily explicable with extant earthquake-cycle modeling, suggesting that they may instead be due to some combination of regional kinematic fault interactions, temporal variations in the strength of lithospheric-scale shear zones, and/or variations in local relative plate motion rate. Whatever the exact causes of these variable behaviors, these observations indicate that either the ratio of geodetic to geologic rates before an earthquake may not be diagnostic of the time to the next earthquake, as predicted by many rheologically based geodynamic models of earthquake-cycle behavior, or different behaviors characterize different fault systems in a manner that is not yet understood or predictable.

  2. Fault location and source process of the 2003 Boumerdes, Algeria, earthquake inferred from geodetic and strong motion data.

    Science.gov (United States)

    Semmane, F.; Campillo, M.; Cotton, F.

    2004-12-01

    The Boumerdes earthquake occurred on a fault which precise location, offshore the algerian coast, was unknown. Geodetic data consist of GPS measurements, levelling points and coastal uplifts. They are first used to determine the absolute position of the fault. We performed a series of inversions assuming different positions and chose the model giving the smallest misfit. According to this analysis, the fault emerge at about 15 km offshore. Accelerograms are then used to infer the space-time history of rupture on the fault plane using a two-step inversion in the spectral domain. The observed strong motion records are in good agreement with the synthetics for the fault location inferred from geodetic data. The fault plane ruptured for about 16 seconds. The slip distribution on the fault indicates one asperity north-west of the hypocenter with a maximum slip amplitude larger than 2.5 m. Another asperity with slightly smaller slip amplitude is located south-east of the hypocenter. The rupture seems to stop its propagation westward when it encounters the Thenia fault, a structure almost perpendicular to the main fault. We computed the spatial distribution of ground motion predicted by this fault model and compared it with the observed damages.

  3. Incorporating Geodetic Data in Introductory Geoscience Classrooms through UNAVCO's GETSI "Ice Mass and Sea Level Changes" Module

    Science.gov (United States)

    Stearns, L. A.; Walker, B.; Pratt-Sitaula, B.

    2015-12-01

    GETSI (Geodesy Tools for Societal Issues) is an NSF-funded partnership program between UNAVCO, Indiana University, Mt. San Antonio College, and the Science Education Resource Center (SERC). We present results from classroom testing and assessment of the GETSI Ice Mass and Sea Level Changes module that utilizes geodetic data to teach about ice sheet mass loss in introductory undergraduate courses. The module explores the interactions between global sea level rise, Greenland ice mass loss, and the response of the solid Earth. It brings together topics typically addressed in introductory Earth science courses (isostatic rebound, geologic measurements, and climate change) in a way that highlights the interconnectivity of the Earth system and the interpretation of geodetic data. The module was tested 3 times at 3 different institution types (R1 institution, comprehensive university, and community college), and formative and summative assessment data were obtained. We will provide an overview of the instructional materials, describe our teaching methods, and discuss how formative and summative assessment data assisted in revisions of the teaching materials and changes in our pedagogy during subsequent implementation of the module. We will also provide strategies for faculty who wish to incorporate the module into their curricula. Instructional materials, faculty and student resources, and implementation tips are freely available on the GETSI website.

  4. Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy.

    Science.gov (United States)

    Saeki, Hiroshi; Emi, Yasunori; Oki, Eiji; Tokunaga, Shoji; Kakeji, Yoshihiro; Akagi, Yoshito; Baba, Hideo; Baba, Eishi; Maehara, Yoshihiko

    2018-01-08

    Oxaliplatin + S-1 is a recognized treatment regimen in Japan, but there are no Japanese clinical data on an oxaliplatin dose of 130 mg/m 2 . The current research involves a single-arm, prospective, phase II clinical trial to examine the efficacy and safety of oxaliplatin + S-1 with an oxaliplatin dose of 130 mg/m 2 to treat HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy in Japan. The primary endpoint of this trial will be the response rate, and the secondary endpoints will be the safety profile of oxaliplatin + S-1, progression-free survival, the response rate in subjects under the age of 75, overall survival, time to treatment failure, duration of treatment, time to failure of strategy, and dose intensity. The threshold response rate is 45% and the expected response rate is 60%. Assuming that a one-tailed score test will be performed with an α of 0.05, 68 patients are needed to ensure a statistical power of 80%. Planned enrollment is 70 subjects and the total duration of this trial is expected to be 3 years. Since replacing cisplatin with oxaliplatin should provide the same level of therapeutic efficacy while limiting adverse events and simplifying treatment, oxaliplatin + S-1 may be increasingly used to treat gastric cancer in Japan. Verifying the efficacy and safety of oxaliplatin + S-1 with an oxaliplatin dose of 130 mg is an important task that the current trial has set out to achieve. The protocol was registered at the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID UMIN000017550) on May 29, 2015. The details are available at the following web address: http://www.umin.ac.jp/ctr/ .

  5. Primary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (TRatamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies.

    Science.gov (United States)

    Bueno, Héctor; Betriu, Amadeo; Heras, Magda; Alonso, Joaquín J; Cequier, Angel; García, Eulogio J; López-Sendón, José L; Macaya, Carlos; Hernández-Antolín, Rosana

    2011-01-01

    To compare primary percutaneous coronary intervention (pPCI) and fibrinolysis in very old patients with ST-segment elevation myocardial infarction (STEMI), in whom head-to-head comparisons between both strategies are scarce. Patients ≥75 years old with STEMI <6 h were randomized to pPCI or fibrinolysis. The primary endpoint was a composite of all-cause mortality, re-infarction, or disabling stroke at 30 days. The trial was prematurely stopped due to slow recruitment after enrolling 266 patients (134 allocated to pPCI and 132 to fibrinolysis). Both groups were well balanced in baseline characteristics. Mean age was 81 years. The primary endpoint was reached in 25 patients in the pPCI group (18.9%) and 34 (25.4%) in the fibrinolysis arm [odds ratio (OR), 0.69; 95% confidence interval (CI) 0.38-1.23; P = 0.21]. Similarly, non-significant reductions were found in death (13.6 vs. 17.2%, P = 0.43), re-infarction (5.3 vs. 8.2%, P = 0.35), or disabling stroke (0.8 vs. 3.0%, P = 0.18). Recurrent ischaemia was less common in pPCI-treated patients (0.8 vs. 9.7%, P< 0.001). No differences were found in major bleeds. A pooled analysis with the two previous reperfusion trials performed in older patients showed an advantage of pPCI over fibrinolysis in reducing death, re-infarction, or stroke at 30 days (OR, 0.64; 95% CI 0.45-0.91). Primary PCI seems to be the best reperfusion therapy for STEMI even for the oldest patients. Early contemporary fibrinolytic therapy may be a safe alternative to pPCI in the elderly when this is not available.

  6. Raw data from orientation studies in crystalline rock areas of the southeastern United States. [Maps, tables of field data and analytical data for sections of North and South Carolina and Georgia, previously reported sites of uranium mineralization

    Energy Technology Data Exchange (ETDEWEB)

    Price, V.

    1976-03-01

    Raw data are presented on orientation studies conducted in crystalline rock areas of the Southeast which were chosen because of published references to uranium mineralization. Preliminary data for four orientation study areas are included. These areas are Lamar County, Georgia; Oconee County, South Carolina; Brush Creek, North Carolina; and North Harper, North Carolina. Sample locality maps, tables of field data, and tables of analytical data are included for each study area. (JGB)

  7. Searching for geodetic transient slip signals along the Parkfield segment of the San Andreas Fault

    Science.gov (United States)

    Rousset, B.; Burgmann, R.

    2017-12-01

    The Parkfield section of the San Andreas fault is at the transition between a segment locked since the 1857 Mw 7.9 Fort Tejon earthquake to its south and a creeping segment to the north. It is particularly well instrumented since it is the many previous studies have focused on studying the coseismic and postseismic phases of the two most recent earthquake cycles, the interseismic phase is exhibiting interesting dynamics at the down-dip edge of the seismogenic zone, characterized by a very large number of low frequency earthquakes (LFE) with different behaviors depending on location. Interseismic fault creep rates appear to vary over a wide range of spatial and temporal scales, from the Earth's surface to the base of crust. In this study, we take advantage of the dense Global Positioning System (GPS) network, with 77 continuous stations located within a circle of radius 80 km centered on Parkfield. We correct these time series for the co- and postseismic signals of the 2003 Mw 6.3 San Simeon and 2004 Mw 6.0 Parkfield earthquakes. We then cross-correlate the residual time series with synthetic slow-slip templates following the approach of Rousset et al. (2017). Synthetic tests with transient events contained in GPS time series with realistic noise show the limit of detection of the method. In the application with real GPS time series, the highest correlation amplitudes are compared with micro-seismicity rates, as well as tremor and LFE observations.

  8. Executive Function in Previously Institutionalized Children.

    Science.gov (United States)

    Merz, Emily C; Harlé, Katia M; Noble, Kimberly G; McCall, Robert B

    2016-06-01

    In studies of children adopted from institutions, being raised in an institution has been associated consistently with an increased risk of persistent cognitive, academic, and social-emotional problems. These findings raise questions about the neurocognitive mechanisms that contribute to these negative outcomes. Theory and models based on studies of animals indicate that development of the prefrontal cortex (PFC) and executive function (EF) may be particularly susceptible to environmental influences during early childhood. In this article, we review recent studies of postinstitutionalized children that examined EF components such as inhibitory control, working memory, shifting, and planning. We then describe emerging research on the structure and function of the PFC. Converging evidence suggests both EF difficulties and alterations in development of the PFC following early institutionalization. We conclude by discussing possible explanations for these findings and implications for prevention and intervention, and by offering suggestions for ongoing research.

  9. [Influence of previous abdominopelvic surgery on gynecological laparoscopic operation].

    Science.gov (United States)

    Jin, Haoran; Shi, Wei; Zhou, Yingfang; Wu, Beisheng; Peng, Chao

    2014-09-01

    To investigate the influence of previous abdominopelvic surgery on gynecological laparoscopic operation. A retrospective analysis of 3 283 cases of gynecological diseases by laparoscopic operation patients in Peking University First Hospital from 2007 January to 2012 December, among them, 719 (21.90%) patients with previous abdominopelvic surgery history (study Group), 2 564 (78.10%)patients have no history of abdominopelvic surgery (control group). Study group 719 patients, previous operation times: one time in 525 cases, 194 cases were multiple; previous operation: 185 cases of gynecological surgery, 305 cases of obstetric surgery, 108 cases of general surgery, and 121 complex surgery (include at least two kinds of surgery); previous operative approach: 650 cases laparotomy and 69 cases laparoscopy. Compared two groups of patients with abdominopelvic adhesion and the gynecologic laparoscopic operation situation, analyzed the influence of previous abdominopelvic surgery on abdominopelvic adhesion on and gynecological laparoscopic operation. The incidence of abdominopelvic adhesion in the patients with previous abdominopelvic surgery was 51.2% (368/719), which was significantly higher than that of 8.2% (211/2 564)in patients without previous abdominopelvic surgery (P surgery (23.1%, 166/719) was significantly higher than that in the control group (3.3% , 85/2 564;P laparotomy was 0.6% (4/719) significantly more than the control groups (0.1%, 2/2 564; P = 0.023). Compared with other groups, patients with gynecological or complex surgery or multiple operation history presented more severe abdominopelvic adhesion both in the score and degree (P laparotomy showed no statistical difference between the two groups (P > 0.05). The laparoscopic operation could be carried out successfully and safely in patients with a history of various abdominopelvic operations, but the conversion rate increases, for patients with a history of multiple operation because of pelvic adhesion

  10. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    Conclusion: The positive effect of education on oral hygiene practices is highlighted in this study. However there is still need for proper health enlightenment in this population with regards to use of the available oral health care facilities. Keywords: Oral hygiene, Pregnancy, Nigeria. Annals of Ibadan Postgraduate Medicine.

  11. Previous utilization of service does not improve timely booking in ...

    African Journals Online (AJOL)

    Previous utilization of service does not improve timely booking in antenatal care: Cross sectional study on timing of antenatal care booking at public health facilities in ... Methods: A cross sectional study was conducted to collect data from 630 pregnant women who were attending antenatal care service at 10 governmental ...

  12. Docking and Molecular Dynamics Calculations of Some Previously Studied and newly Designed Ligands to Catalytic Core Domain of HIV-1 Integrase and an Investigation to Effects of Conformational Changes of Protein on Docking Results

    Directory of Open Access Journals (Sweden)

    Selami Ercan

    2016-10-01

    Full Text Available Nowadays, AIDS still remains as a worldwide pandemic and continues to cause many death which arise from HIV-1 virus. For nearly 35 years, drugs that target various steps of virus life cycle have been developed. HIV-1 integrase is the one of these steps which is essential for virus life cycle. Computer aided drug design is being used in many drug design studies as also used in development of the first HIV-1 integrase inhibitor Raltegravir. In this study 3 ligands which are used as HIV-1 integrase inhibitors and 4 newly designed ligands were docked to catalytic core domain of HIV-1 integrase. Each of ligands docked to three different conformations of protein. Prepared complexes (21 item were carried out by 50 ns MD simulations and results were analyzed. Finally, the binding free energies of ligands were calculated. Hereunder, it was determined that designed ligands L01 and L03 gave favorable results. The questions about the ligands which have low docking scores in a conformation of protein could give better scores in another conformation of protein and if the MD simulations carry the different oriented and different localized ligands in same position at the end of simulation were answered.

  13. Janus kinase-2 inhibitor fedratinib in patients with myelofibrosis previously treated with ruxolitinib (JAKARTA-2): a single-arm, open-label, non-randomised, phase 2, multicentre study.

    Science.gov (United States)

    Harrison, Claire N; Schaap, Nicolaas; Vannucchi, Alessandro M; Kiladjian, Jean-Jacques; Tiu, Ramon V; Zachee, Pierre; Jourdan, Eric; Winton, Elliott; Silver, Richard T; Schouten, Harry C; Passamonti, Francesco; Zweegman, Sonja; Talpaz, Moshe; Lager, Joanne; Shun, Zhenming; Mesa, Ruben A

    2017-07-01

    Myelofibrosis is a chronic myeloproliferative neoplasm characterised by splenomegaly, cytopenias, bone marrow fibrosis, and debilitating symptoms including fatigue, weight loss, and bone pain. Mutations in Janus kinase-2 (JAK2) occur in approximately 50% of patients. The only approved JAK2 inhibitor for myelofibrosis is the dual JAK1 and JAK2 inhibitor, ruxolitinib. 58-71% of patients treated with ruxolitinib in clinical trials so far have not achieved the primary endpoint of 35% or more reduction in spleen volume from baseline assessed by MRI or CT. Furthermore, more than 50% of patients discontinue ruxolitinib treatment after 3-5 years. On the basis of this unmet need, we investigated the efficacy and safety of fedratinib, a JAK2-selective inhibitor, in patients with ruxolitinib-resistant or ruxolitinib-intolerant myelofibrosis. This single-arm, open-label, non-randomised, phase 2, multicentre study, done at 31 sites in nine countries, enrolled adult patients with a current diagnosis of intermediate or high-risk primary myelofibrosis, post-polycythaemia vera myelofibrosis, or post-essential thrombocythaemia myelofibrosis, found to be ruxolitinib resistant or intolerant after at least 14 days of treatment. Other main inclusion criteria were palpable splenomegaly (≥5 cm below the left costal margin), Eastern Cooperative Oncology Group performance status of 2 or less, and life expectancy of 6 months or less. Patients received oral fedratinib at a starting dose of 400 mg once per day, for six consecutive 28-day cycles. The primary endpoint was spleen response (defined as the proportion of patients with a ≥35% reduction in spleen volume as determined by blinded CT and MRI at a central imaging laboratory). We did the primary analysis in the per-protocol population only (patients treated with fedratinib, for whom a baseline and at least one post-baseline spleen volume measurement was available) and the safety analysis in all patients receiving at least one dose of

  14. Discoveries and Controversies in Geodetic Imaging of Deformation Before and After the M=9 Tohoku-oki Earthquake

    Science.gov (United States)

    Wang, K.; Sun, T.; Hino, R.; Iinuma, T.; Tomita, F.; Kido, M.

    2017-12-01

    Numerous observations pertaining to the M=9.0 2011 Tohoku-oki earthquake have led to new understanding of subduction zone earthquakes. By synthesizing published research results and our own findings, we explore what has been learned about fault behavior and Earth rheology from geodetic imaging of crustal deformation before and after the earthquake. Before the earthquake, megathrust locking models based on land-based geodetic observations correctly outlined the along-strike location of the future rupture zone, showing that land-based observations are capable of resolving along-strike variations in locking and creep at wavelengths comparable to distances from the network. But they predicted a locked zone that was much deeper than the actual rupture in 2011. The incorrect definition of the locking pattern in the dip direction demonstrates not only the need for seafloor geodesy but also the importance of modeling interseismic viscoelastic stress relaxation and stress shadowing. The discovery of decade-long accelerated slip downdip of the future rupture zone raises new questions on fault mechanics. After the earthquake, seafloor geodetic discovery of opposing motion offshore provided unambiguous evidence for the dominance of viscoelastic relaxation in short-term postseismic deformation. There is little deep afterslip in the fault area where the decade-long pre-earthquake slip acceleration is observed. The complementary spatial distribution of pre-slip and afterslip calls for new scientific research. However, the near absence of deep afterslip directly downdip of the main rupture is perceived to be controversial because some viscoelastic models do predict large afterslip here, although less than predicted by purely elastic models. We show that the large afterslip in these models is largely an artefact due to the use of a layered Earth model without a subducting slab. The slab acts as an "anchor" in the mantle and retards landward motion following a subduction earthquake

  15. Undergraduate teaching modules featuring geodesy data applied to critical social topics (GETSI: GEodetic Tools for Societal Issues)

    Science.gov (United States)

    Pratt-Sitaula, B. A.; Walker, B.; Douglas, B. J.; Charlevoix, D. J.; Miller, M. M.

    2015-12-01

    The GETSI project, funded by NSF TUES, is developing and disseminating teaching and learning materials that feature geodesy data applied to critical societal issues such as climate change, water resource management, and natural hazards (serc.carleton.edu/getsi). It is collaborative between UNAVCO (NSF's geodetic facility), Mt San Antonio College, and Indiana University. GETSI was initiated after requests by geoscience faculty for geodetic teaching resources for introductory and majors-level students. Full modules take two weeks but module subsets can also be used. Modules are developed and tested by two co-authors and also tested in a third classroom. GETSI is working in partnership with the Science Education Resource Center's (SERC) InTeGrate project on the development, assessment, and dissemination to ensure compatibility with the growing number of resources for geoscience education. Two GETSI modules are being published in October 2015. "Ice mass and sea level changes" includes geodetic data from GRACE, satellite altimetry, and GPS time series. "Imaging Active Tectonics" has students analyzing InSAR and LiDAR data to assess infrastructure earthquake vulnerability. Another three modules are in testing during fall 2015 and will be published in 2016. "Surface process hazards" investigates mass wasting hazard and risk using LiDAR data. "Water resources and geodesy" uses GRACE, vertical GPS, and reflection GPS data to have students investigating droughts in California and the High Great Plains. "GPS, strain, and earthquakes" helps students learn about infinitesimal and coseismic strain through analysis of horizontal GPS data and includes an extension module on the Napa 2014 earthquake. In addition to teaching resources, the GETSI project is compiling recommendations on successful development of geodesy curricula. The chief recommendations so far are the critical importance of including scientific experts in the authorship team and investing significant resources in

  16. A phase II study of nanoparticle albumin-bound paclitaxel plus carboplatin as the first-line therapy in elderly patients with previously untreated advanced non-small cell lung cancer.

    Science.gov (United States)

    Okuma, Yusuke; Hosomi, Yukio; Takahashi, Satoshi; Nakahara, Yoshiro; Watanabe, Kageaki; Nagamata, Makoto; Takagi, Yusuke; Mikura, Shinichiro

    2016-08-01

    The objective of this clinical trial was to explore the efficacy and tolerability of first-line chemotherapy with nanoparticle albumin-bound paclitaxel (nab-paclitaxel), a novel agent that uses a drug delivery system, plus carboplatin, in elderly Japanese patients with advanced non-small cell lung cancer (NSCLC). In this phase II, single-arm, open-label, single-institutional study, we aimed to enroll 37 elderly patients, aged more than 70 years, with advanced NSCLC of performance status 0 or 1. The patients received each cycle of first-line therapy consisting of 100 mg/m(2) nab-paclitaxel intravenously administered on days 1, 8, and 15 of each 21-day cycle, plus carboplatin area under curve 6 on day 1 of each 21-day cycle, for up to six cycles. The primary end point was determining the objective response rate, and secondary endpoints were progression-free survival, overall survival, and safety. The study was interrupted early because of two treatment-related deaths and 1 life-threatening severe adverse event; therefore, only 10 patients (median age, 77 years; range 71-82 years) were enrolled. The primary end point of the objective response was 50 % for the 10 patients analyzed. Progression-free survival was 4.48 months [95 % confidence interval (CI) 0.36-6.44], and overall survival was 7.89 months (95 % CI 0.36-26.88). Common treatment-related adverse events higher than grade 2 included decreased neutrophil counts, anemia, decreased albumin, anorexia, and peripheral neuropathy. Regarding severe adverse events, two patients had febrile neutropenia and lung infection. Two patients died, and one patient had febrile neutropenia with intubation during the first cycle. The Data and Safety Monitoring Committee therefore recommended interruption of patient enrollment. Nab-paclitaxel plus carboplatin, without dose reduction, is indicated to be toxic and intolerable as first-line chemotherapy in elderly Japanese patients with advanced NSCLC. Care must be taken when

  17. Local recurrence risk after previous salvage mastectomy.

    Science.gov (United States)

    Tanabe, M; Iwase, T; Okumura, Y; Yoshida, A; Masuda, N; Nakatsukasa, K; Shien, T; Tanaka, S; Komoike, Y; Taguchi, T; Arima, N; Nishimura, R; Inaji, H; Ishitobi, M

    2016-07-01

    Breast-conserving surgery is a standard treatment for early breast cancer. For ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery, salvage mastectomy is the current standard surgical procedure. However, it is not rare for patients with IBTR who have received salvage mastectomy to develop local recurrence. In this study, we examined the risk factors of local recurrence after salvage mastectomy for IBTR. A total of 118 consecutive patients who had histologically confirmed IBTR without distant metastases and underwent salvage mastectomy without irradiation for IBTR between 1989 and 2008 were included from eight institutions in Japan. The risk factors of local recurrence were assessed. The median follow-up period from salvage mastectomy for IBTR was 4.6 years. Patients with pN2 or higher on diagnosis of the primary tumor showed significantly poorer local recurrence-free survival than those with pN0 or pN1 at primary tumor (p mastectomy for IBTR. Further research and validation studies are needed. (UMIN-CTR number UMIN000008136). Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Twelve-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg and 400/10 microg combination treatments in patients with persistent asthma previously receiving high-dose inhaled corticosteroids

    DEFF Research Database (Denmark)

    Weinstein, Steven F; Corren, Jonathan; Murphy, Kevin

    2010-01-01

    improvement in lung function throughout 12 weeks. Both MF/F doses were superior to MF in improving asthma control and reducing nocturnal awakenings due to asthma requiring short-acting beta(2)-agonist use. All treatments were well tolerated. Asthma patients who were poorly controlled on high-dose ICS...... with asthma uncontrolled on high-dose inhaled corticosteroids (ICS). In a 12-week, randomized, multicenter, double-blind, parallel-group study, patients (>or=12 years of age) were randomized to MF/F 200/10 microg, MF/F 400/10 microg, or MF 400 microg, b.i.d. after a 2- to 3-week open-label run in with MF 400...... recorded. Seven hundred twenty-eight patients were randomized. Significant improvement from baseline to week 12 occurred for mean change in FEV(1) AUC(0-12h) with MF/F 400/10 microg (4.19 L x hour) versus MF 400 microg (2.04 L x hour; p

  19. A multicenter, open-label, randomized phase II controlled study of rh-endostatin (Endostar) in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer.

    Science.gov (United States)

    Lu, Shun; Li, Lu; Luo, Yi; Zhang, Li; Wu, Gang; Chen, Zhiwei; Huang, Cheng; Guo, Shuliang; Zhang, Yiping; Song, Xiangqun; Yu, Yongfeng; Zhou, Caicun; Li, Wei; Liao, Meilin; Li, Baolan; Xu, Liyan; Chen, Ping; Hu, Chunhong; Hu, Chengping

    2015-01-01

    Based on promising efficacy in a single-arm study, a randomized phase II trial was designed to compare the efficacy and safety of adding rh-endostatin (Endostar) to first-line standard etoposide and carboplatin (EC) chemotherapy for treatment of extensive-stage small-cell lung cancer. One hundred forty Chinese patients with pathologically confirmed, extensive-stage small-cell lung cancer were randomly assigned to EC alone or rh-endostatin + EC for 4-6 cycles, followed by single-agent rh-endostatin until progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, Objective response rate (ORR), and quality of life. Median PFS was 6.4 months with rh-endostatin + EC (n = 69) and 5.9 months with EC (n = 69) (hazard ratio 0.8 [95% confidence interval 0.6-1.1]). PFS was significantly higher with rh-endostatin + EC than with EC (hazard ratio 0.4 [0.2-0.9; p = 0.020]) in female. Median overall survival was similar in both groups (12.1 versus 12.4 months, respectively [p = 0.82]). ORR was higher in the rh-endostatin + EC group (75.4%) than in the EC group (66.7%) (p = 0.348). The efficacy of rh-endostatin + EC relative to that of EC was reflected by greater improvements in patient-assessed quality of life scores after 4 and 6 weeks of treatment. There was no difference between each regimen in the incidence of nonhematological or Grade III-IV hematological toxicities. Addition of rh-endostatin to EC for the treatment of extensive-stage small-cell lung cancer had an acceptable toxicity profile, but did not improve overall survival, PFS, and ORR.

  20. Interseismic and coseismic surface deformation deduced from space geodetic observations : with inferences on seismic hazard, tectonic processes, earthquake complexity, and slip distribution

    NARCIS (Netherlands)

    Bos, A.G. (Annemarie Gerredina)

    2003-01-01

    In this thesis I am concerned with modeling the kinematics of surface deformation using space geodetic observations in order to advance insight in both interseismic and coseismic surface response. To model the surface deformation field I adopt the method of Spakman and Nyst (2002) which resolves the

  1. Endoscopic Third Ventriculostomy in Previously Shunted Children

    Directory of Open Access Journals (Sweden)

    Eva Brichtova

    2013-01-01

    Full Text Available Endoscopic third ventriculostomy (ETV is a routine and safe procedure for therapy of obstructive hydrocephalus. The aim of our study is to evaluate ETV success rate in therapy of obstructive hydrocephalus in pediatric patients formerly treated by ventriculoperitoneal (V-P shunt implantation. From 2001 till 2011, ETV was performed in 42 patients with former V-P drainage implantation. In all patients, the obstruction in aqueduct or outflow parts of the fourth ventricle was proved by MRI. During the surgery, V-P shunt was clipped and ETV was performed. In case of favourable clinical state and MRI functional stoma, the V-P shunt has been removed 3 months after ETV. These patients with V-P shunt possible removing were evaluated as successful. In our group of 42 patients we were successful in 29 patients (69%. There were two serious complications (4.7%—one patient died 2.5 years and one patient died 1 year after surgery in consequence of delayed ETV failure. ETV is the method of choice in obstructive hydrocephalus even in patients with former V-P shunt implantation. In case of acute or scheduled V-P shunt surgical revision, MRI is feasible, and if ventricular system obstruction is diagnosed, the hydrocephalus may be solved endoscopically.

  2. Indiscriminate behaviors in previously institutionalized young children.

    Science.gov (United States)

    Gleason, Mary Margaret; Fox, Nathan A; Drury, Stacy S; Smyke, Anna T; Nelson, Charles A; Zeanah, Charles H

    2014-03-01

    This study included 54-month-old children with a history of institutional care. Our goal was to: (1) examine differences in indiscriminate social behaviors in children with a history of institutional care compared with home-reared children; (2) test whether foster care reduces indiscriminate social behaviors in a randomized controlled trial; and (3) examine early predictors of indiscriminate behaviors. Participants were 58 children with a history of institutional care and 31 never-institutionalized control (NIG) subjects enrolled in a randomized controlled trial of foster care for institutional care, assessed from toddlerhood to 54 months. Indiscriminate social behaviors were measured naturalistically by using the Stranger at the Door procedure. In the Stranger at the Door procedure, children with a history of institutional care left with a stranger at higher rates than NIG subjects (33% vs. 3.5%; P Children in the care as usual group left more than NIG subjects (41.9% vs. 3.6%; P ≤ .001). The differences between the foster care group (24.1%) and the care as usual group and between foster care group and NIG were not significant. In a logistic regression, early disorganized attachment behaviors, baseline developmental quotient, and caregiving quality after randomization contributed to variance at 54 months. In the same analysis using only children with a history of institutional care, only disorganized attachment contributed significantly to 54-month indiscriminate social behaviors (Exp[B] = 1.6 [95% confidence interval: 1.1-2.5]). Observed socially indiscriminate behaviors at 54 months were associated with prolonged exposure to institutional care. Young children raised in conditions of deprivation who fail to develop organized attachments as toddlers are at increased risk for subsequent indiscriminate behaviors.

  3. Research Article. Geodesic equations and their numerical solutions in geodetic and Cartesian coordinates on an oblate spheroid

    Directory of Open Access Journals (Sweden)

    Panou G.

    2017-02-01

    Full Text Available The direct geodesic problem on an oblate spheroid is described as an initial value problem and is solved numerically using both geodetic and Cartesian coordinates. The geodesic equations are formulated by means of the theory of differential geometry. The initial value problem under consideration is reduced to a system of first-order ordinary differential equations, which is solved using a numerical method. The solution provides the coordinates and the azimuths at any point along the geodesic. The Clairaut constant is not used for the solution but it is computed, allowing to check the precision of the method. An extensive data set of geodesics is used, in order to evaluate the performance of the method in each coordinate system. The results for the direct geodesic problem are validated by comparison to Karney’s method. We conclude that a complete, stable, precise, accurate and fast solution of the problem in Cartesian coordinates is accomplished.

  4. Research Article. Geodesic equations and their numerical solutions in geodetic and Cartesian coordinates on an oblate spheroid

    Science.gov (United States)

    Panou, G.; Korakitis, R.

    2017-02-01

    The direct geodesic problem on an oblate spheroid is described as an initial value problem and is solved numerically using both geodetic and Cartesian coordinates. The geodesic equations are formulated by means of the theory of differential geometry. The initial value problem under consideration is reduced to a system of first-order ordinary differential equations, which is solved using a numerical method. The solution provides the coordinates and the azimuths at any point along the geodesic. The Clairaut constant is not used for the solution but it is computed, allowing to check the precision of the method. An extensive data set of geodesics is used, in order to evaluate the performance of the method in each coordinate system. The results for the direct geodesic problem are validated by comparison to Karney's method. We conclude that a complete, stable, precise, accurate and fast solution of the problem in Cartesian coordinates is accomplished.

  5. Influence of previous knowledge in Torrance tests of creative thinking

    OpenAIRE

    Aranguren, María; Consejo Nacional de Investigaciones Científicas y Técnicas CONICET

    2015-01-01

    The aim of this work is to analyze the influence of study field, expertise and recreational activities participation in Torrance Tests of Creative Thinking (TTCT, 1974) performance. Several hypotheses were postulated to explore the possible effects of previous knowledge in TTCT verbal and TTCT figural university students’ outcomes. Participants in this study included 418 students from five study fields: Psychology;Philosophy and Literature, Music; Engineering; and Journalism and Advertisin...

  6. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2011-01-01

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  7. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2012-01-31

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  8. Balance and bilateral skills of selected previously disadvantaged ...

    African Journals Online (AJOL)

    Balance and bilateral skills of selected previously disadvantaged children aged 9 to 12 years. Eileen K Africa, Karel J Van Deventer. Abstract. The main aim of the study was to design an appropriate motor skills development programme that could be implemented in any primary school to improve the fundamental motor ...

  9. Suburethral sling procedures after previous surgery for urinary ...

    African Journals Online (AJOL)

    Objective. To compare the outcome of suburethral sling procedures (tension-free vaginal tape (TVT), obturator tape (Ob-tape)) for stress urinary incontinence (SUI) in women with previous surgery for SUI or pelvic organ prolapse (POP). Methods. A comparative, descriptive, retrospective study was done using information ...

  10. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    The aim of this study was to identify influences on the job satisfaction of previously disadvantaged school principals in North-West Province. Evans's theory of job satisfaction, morale and motivation was useful as a conceptual framework. A mixedmethods explanatory research design was important in discovering issues with ...

  11. Determination of recent horizontal crustal movements and deformations of African and Eurasian plates in western Mediterranean region using geodetic-GPS computations extended to 2006 (from 1997) related to NAFREF and AFREF frames.

    Science.gov (United States)

    Azzouzi, R.

    2009-04-01

    Determination of recent horizontal crustal movements and deformations of African and Eurasian plates in western Mediterranean region using geodetic-GPS computations extended to 2006 (from 1997) related to NAFREF and AFREF frames. By: R. Azzouzi*, M. Ettarid*, El H. Semlali*, et A. Rimi+ * Filière de Formation en Topographie Institut Agronomique et Vétérinaire Hassan II B.P. 6202 Rabat-Instituts MAROC + Département de la Physique du Globe Université Mohammed V Rabat MAROC This study focus on the use of the geodetic spatial technique GPS for geodynamic purposes generally in the Western Mediterranean area and particularly in Morocco. It aims to exploit this technique first to determine the geodetic coordinates on some western Mediterranean sites. And also this technique is used to detect and to determine movements cross the boundary line between the two African and Eurasian crustal plates on some well chosen GPS-Geodynamics sites. It will allow us also to estimate crustal dynamic parameters of tension that results. These parameters are linked to deformations of terrestrial crust in the region. They are also associated with tectonic constraints of the study area. The usefulness of repeated measurements of these elements, the estimate of displacements and the determination of their temporal rates is indisputable. Indeed, sismo-tectonique studies allow a good knowledge of the of earthquake processes, their frequency their amplitude and even of their prediction in the world in general and in Moroccan area especially. They allow also contributing to guarantee more security for all most important management projects, as projects of building great works (dams, bridges, nuclear centrals). And also as preliminary study, for the most important joint-project between Europe and Africa through the Strait of Gibraltar. For our application, 23 GPS monitoring stations under the ITRF2000 reference frame are chosen in Eurasian and African plates. The sites are located around the

  12. Event Sequence Variability in Healthy Swallowing: Building on Previous Findings

    OpenAIRE

    Molfenter, Sonja M.; Leigh, Chelsea; Steele, Catriona M.

    2014-01-01

    This study builds on previous work by Kendall, Leonard and McKenzie, which investigated event sequence variability for 12 paired-events during swallowing by healthy volunteers. They identified four event pairs, which always occurred in a stereotyped order as well as a most-common occurring overall order of events during swallowing. In the current study, we investigate overall event sequencing and the same four paired-events in a sample of swallows by healthy, young (under 45 years old) volunt...

  13. Response to health insurance by previously uninsured rural children.

    Science.gov (United States)

    Tilford, J M; Robbins, J M; Shema, S J; Farmer, F L

    1999-08-01

    To examine the healthcare utilization and costs of previously uninsured rural children. Four years of claims data from a school-based health insurance program located in the Mississippi Delta. All children who were not Medicaid-eligible or were uninsured, were eligible for limited benefits under the program. The 1987 National Medical Expenditure Survey (NMES) was used to compare utilization of services. The study represents a natural experiment in the provision of insurance benefits to a previously uninsured population. Premiums for the claims cost were set with little or no information on expected use of services. Claims from the insurer were used to form a panel data set. Mixed model logistic and linear regressions were estimated to determine the response to insurance for several categories of health services. The use of services increased over time and approached the level of utilization in the NMES. Conditional medical expenditures also increased over time. Actuarial estimates of claims cost greatly exceeded actual claims cost. The provision of a limited medical, dental, and optical benefit package cost approximately $20-$24 per member per month in claims paid. An important uncertainty in providing health insurance to previously uninsured populations is whether a pent-up demand exists for health services. Evidence of a pent-up demand for medical services was not supported in this study of rural school-age children. States considering partnerships with private insurers to implement the State Children's Health Insurance Program could lower premium costs by assembling basic data on previously uninsured children.

  14. The effect of previous traumatic injury on homicide risk.

    Science.gov (United States)

    Griffin, Russell L; Davis, Gregory G; Levitan, Emily B; MacLennan, Paul A; Redden, David T; McGwin, Gerald

    2014-07-01

    Research has reported that a strong risk factor for traumatic injury is having a previous injury (i.e., recidivism). To date, the only study examining the relationship between recidivism and homicide reported strong associations, but was limited by possible selection bias. The current matched case-control study utilized coroner's data from 2004 to 2008. Subjects were linked to trauma registry data to determine whether the person had a previous traumatic injury. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between homicide and recidivism. Homicide risk was increased for those having a previous traumatic injury (OR 1.81, 95% CI 1.09-2.99) or a previous intentional injury (OR 2.53, 95% CI 1.24-5.17). These results suggest an association between homicide and injury recidivism, and that trauma centers may be an effective setting for screening individuals for secondary prevention efforts of homicide through violence prevention programs. © 2014 American Academy of Forensic Sciences.

  15. Nicotine Elicits Methamphetamine-Seeking in Rats Previously Administered Nicotine

    OpenAIRE

    Neugebauer, N. M.; Harrod, S. B.; Bardo, M. T.

    2009-01-01

    Research has indicated a high correlation between psychostimulant use and tobacco cigarette smoking in human substance abusers. The objective of the current study was to examine the effects of acute and repeated nicotine administration on responding for intravenous methamphetamine (0.03 mg/kg/infusion) in a rodent model of self-administration, as well as the potential of nicotine to induce reinstatement of previously extinguished drug-taking behavior in male Sprague-Dawley rats. In addition, ...

  16. Permanent terrestrial geodetic system for monitoring the stability of the 2007 Lava Fan in the Sciara de Fuoco (Stromboli volcano, Italy)

    Science.gov (United States)

    Bonforte, A.; Cantarero, M.; Puglisi, G.; Spata, A.

    2009-04-01

    At the end of the 2002-2003 eruption, a terrestrial monitoring system was installed for routinely measuring the movements of benchmarks installed inside the Sciara del Fuoco (hereafter SdF) (Puglisi et al., 2005). This system, named THEODOROS, is based on a remotely controlled robotized Total Station installed near Punta Labronzo, on the northern border of the SdF. The 2007 eruption caused a dramatic change in the operations of THEODOROS. The 2007 lava flows, indeed, destroyed all benchmarks installed on the northern part of the SdF, leaving only those on its central part. This eruption produced a lava fan at the base of the SdF, due to the rapid cooling of the lava flows when entering into the sea. the continuous overlapping of several flows during the eruption, indeed, build a thick lava body (the fan); it was emplaced on a very steep slope, partially originated during the landslides occurred on December 2002, producing an hazard condition due to the possible fast sliding of this fan into the sea. In order to monitor the stability of this lava fan, a new terrestrial geodetic network, was implemented on 6 April 2007, by installing 5 reflectors along a profile crossing the lava body, approximately over the old coastline. Later on, in June 2007, 4 further reflectors were installed at higher and lower altitude with respect to the previous profile, to obtain more information on the overall deformation of the lava body. Measurements were rather noisy during the first months, but a better definition of the reference system strongly improved the quality of the data. The position of the 9 benchmarks over the lava fan allows the areal distribution of the deformation to be drawn. The measurements carried out every 10 minutes allow us to follow with high temporal detail their motion. The data collected since the end of the eruption highlighted a significant downslope motion of the entire lava fan, decreasing from the South to the North, where the body is buttressed by the

  17. Geostatistical Investigations of Displacements on the Basis of Data from the Geodetic Monitoring of a Hydrotechnical Object

    Science.gov (United States)

    Namysłowska-Wilczyńska, Barbara; Wynalek, Janusz

    2017-12-01

    Geostatistical methods make the analysis of measurement data possible. This article presents the problems directed towards the use of geostatistics in spatial analysis of displacements based on geodetic monitoring. Using methods of applied (spatial) statistics, the research deals with interesting and current issues connected to space-time analysis, modeling displacements and deformations, as applied to any large-area objects on which geodetic monitoring is conducted (e.g., water dams, urban areas in the vicinity of deep excavations, areas at a macro-regional scale subject to anthropogenic influences caused by mining, etc.). These problems are very crucial, especially for safety assessment of important hydrotechnical constructions, as well as for modeling and estimating mining damage. Based on the geodetic monitoring data, a substantial basic empirical material was created, comprising many years of research results concerning displacements of controlled points situated on the crown and foreland of an exemplary earth dam, and used to assess the behaviour and safety of the object during its whole operating period. A research method at a macro-regional scale was applied to investigate some phenomena connected with the operation of the analysed big hydrotechnical construction. Applying a semivariogram function enabled the spatial variability analysis of displacements. Isotropic empirical semivariograms were calculated and then, theoretical parameters of analytical functions were determined, which approximated the courses of the mentioned empirical variability measure. Using ordinary (block) kriging at the grid nodes of an elementary spatial grid covering the analysed object, the values of the Z* estimated means of displacements were calculated together with the accompanying assessment of uncertainty estimation - a standard deviation of estimation σk. Raster maps of the distribution of estimated averages Z* and raster maps of deviations of estimation σk (in perspective

  18. Event sequence variability in healthy swallowing: building on previous findings.

    Science.gov (United States)

    Molfenter, Sonja M; Leigh, Chelsea; Steele, Catriona M

    2014-04-01

    This study builds on previous work by Kendall, Leonard, and McKenzie, which investigated event sequence variability for 12 paired events during swallowing by healthy volunteers. They identified four event pairs that always occurred in a stereotyped order and a most common occurring overall order of events during swallowing. In the current study, we investigated overall event sequencing and the same four paired events in a sample of swallows by healthy young (under 45 years old) volunteers. Data were collected during a 16-swallow lateral videofluoroscopy protocol, which included manipulations of bolus volume, barium density, bolus viscosity, and swallow cueing. Our results agreed with previous findings that variable event sequencing is found in healthy swallowing, and, in regard to obligatory sequencing of two paired events, movement of the arytenoids toward the base of the epiglottis begins prior to upper esophageal sphincter (UES) opening and maximum hyolaryngeal approximation occurs after UES opening. However, our data failed to replicate the previous findings that there is obligatory sequencing of maximum pharyngeal constriction after maximal UES distension and the UES opens before bolus arrival at the UES. The most common observed overall event sequence reported by Kendall et al. was observed in only 4/293 swallows in our dataset. Manipulations of bolus volume, bolus viscosity, barium concentration, swallow cueing, and swallow repetitions could not completely account for the differences observed between the two studies.

  19. Geodetic Control Points, Chippewa County has been working on tightening up their control network over the years. The first network was constructed in 1993, with densification done from 2008-2011., Published in 2011, Not Applicable scale, Chippewa County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Geodetic Control Points dataset current as of 2011. Chippewa County has been working on tightening up their control network over the years. The first network was...

  20. Workshop targets development of geodetic transient detection methods: 2009 SCEC Annual Meeting: Workshop on transient anomalous strain detection; Palm Springs, California, 12-13 September 2009

    Science.gov (United States)

    Murray-Moraleda, Jessica R.; Lohman, Rowena

    2010-01-01

    The Southern California Earthquake Center (SCEC) is a community of researchers at institutions worldwide working to improve understanding of earthquakes and mitigate earthquake risk. One of SCEC's priority objectives is to “develop a geodetic network processing system that will detect anomalous strain transients.” Given the growing number of continuously recording geodetic networks consisting of hundreds of stations, an automated means for systematically searching data for transient signals, especially in near real time, is critical for network operations, hazard monitoring, and event response. The SCEC Transient Detection Test Exercise began in 2008 to foster an active community of researchers working on this problem, explore promising methods, and combine effective approaches in novel ways. A workshop was held in California to assess what has been learned thus far and discuss areas of focus as the project moves forward.

  1. Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home

    NARCIS (Netherlands)

    Renard, Eric; Farret, Anne; Kropff, Jort; Bruttomesso, Daniela; Messori, Mirko; Place, Jerome; Visentin, Roberto; Calore, Roberta; Toffanin, Chiara; Di Palma, Federico; Lanzola, Giordano; Magni, Paolo; Boscari, Federico; Galasso, Silvia; Avogaro, Angelo; Keith-Hynes, Patrick; Kovatchev, Boris; del Favero, Simone; Cobelli, Claudio; Magni, Lalo; DeVries, J. Hans

    2016-01-01

    After testing of a wearable artificial pancreas (AP) during evening and night (E/N-AP) under free-living conditions in patients with type 1 diabetes (T1D), we investigated AP during day and night (D/N-AP) for 1 month. Twenty adult patients with T1D who completed a previous randomized crossover study

  2. The long-term consequences of previous hyperthyroidism

    DEFF Research Database (Denmark)

    Hjelm Brandt Kristensen, Frans

    2015-01-01

    vascular state. While it is biologically plausible that these changes may induce long-term consequences, the insight into morbidity as well as mortality in patients with previous hyperthyroidism is limited. The reasons for this are a combination of inadequately powered studies, varying definitions......,400 non-hyperthyroid control individuals (matched for age and sex), all identified from a random 5% sample of the Danish background population (n=339,481). In the second study population, 625 same-sex twin pairs, discordant for hyperthyroidism, were included. For each individual, the degree of co...

  3. Defining Geodetic Reference Frame using Matlab®: PlatEMotion 2.0

    Science.gov (United States)

    Cannavò, Flavio; Palano, Mimmo

    2016-03-01

    We describe the main features of the developed software tool, namely PlatE-Motion 2.0 (PEM2), which allows inferring the Euler pole parameters by inverting the observed velocities at a set of sites located on a rigid block (inverse problem). PEM2 allows also calculating the expected velocity value for any point located on the Earth providing an Euler pole (direct problem). PEM2 is the updated version of a previous software tool initially developed for easy-to-use file exchange with the GAMIT/GLOBK software package. The software tool is developed in Matlab® framework and, as the previous version, includes a set of MATLAB functions (m-files), GUIs (fig-files), map data files (mat-files) and user's manual as well as some example input files. New changes in PEM2 include (1) some bugs fixed, (2) improvements in the code, (3) improvements in statistical analysis, (4) new input/output file formats. In addition, PEM2 can be now run under the majority of operating systems. The tool is open source and freely available for the scientific community.

  4. Monitoring of Large Scale Volcanic Deformations in the Andes Using Geodetic Time Series (DInSAR, GPS and Microgravity)

    Science.gov (United States)

    Remy, D.; Froger, J. L.; Bonvalot, S.; Gabalda, G.; Albino, F.; Byrdina, S.

    2010-03-01

    Lastarria (25°10'S, 68°31'W, 5706 m) and Cordon del Azufre (25°18'S, 68°33'W, 5480 m) are part of a broad polygenic quaternary volcanic complex lying on the Altiplano, on the border of Chile and Argentina. This large scale volcanic area attracted particular attention in recent years because of its relatively intense unrest characterised by a peculiar style of on-going ground deformation, apparently begun in 1998. Interferometric Synthetic Aperture Radar (InSAR) data collected between 1998 and 2009 revealed two scales of inflation: a large elliptical area (50 km NNE- SSW major axis and a 40 minor axis), which has been inflating at a rate of around 3 cm.yr-1; and a short wavelength inflation (6 km wide), which is located at Lastarria volcano on the northern margin of the large elliptical area. The temporal evolution of these two distinct inflating signals suggests that they could be linked. The origin of this inflation period is still debated and various source mechanisms have been proposed to explain the observed deformation. Here, we present new observations of surface deformation in the Lastarria-Cordon del Azufre complex based on InSAR, levelling global positioning system (GPS), and microgravity data. Ascending and descending ASAR interferograms are combined to determine vertical and the EW horizontal component of displacement. Geodetic data are discussed from the standpoint of providing better constraints to understand the mechanics of the observed process at the volcanic complex.

  5. Prevalence of Infraumbilical Adhesions in Women With Previous Laparoscopy

    Science.gov (United States)

    Ku, Lowell; Wong, Herb; Liu, C. Y.; Phelps, John Y.

    2007-01-01

    Background and Objectives: The aim of this study is to evaluate the prevalence of intraabdominal adhesions to the umbilicus following gynecologic laparoscopy through an umbilical incision. Methods: A retrospective review was performed of all gynecologic laparoscopic procedures in a private practice setting to identify patients with a repeat laparoscopy who had a history of a previous laparoscopy through an umbilical incision. Patients with a history of other surgeries were excluded. All repeat laparoscopies used a left upper quadrant entry technique where the abdominal cavity was surveyed for adhesions. We also reviewed adverse events attributable to the left upper quadrant entry approach. Results: We identified 151 patients who underwent a second laparoscopy and had a previous umbilical scar. Thirty-two of the 151 (21.2%) patients with a history of a laparoscopy had evidence of adhesions to the umbilical undersurface. No adverse events or injuries were attributed to the left upper quadrant entry technique. Conclusions: Adhesions to the umbilical undersurface occur in 21.2% of patients who have undergone a prior laparoscopy through an umbilical incision. For this reason, we recommend an alternate location for entry in patients with an umbilical scar from a previous laparoscopy. PMID:17651555

  6. Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy.

    Science.gov (United States)

    Spinillo, Arsenio; Beneventi, Fausta; Ramoni, Véronique; Caporali, Roberto; Locatelli, Elena; Simonetta, Margherita; Cavagnoli, Chiara; Alpini, Claudia; Albonico, Giulia; Prisco, Elena; Montecucco, Carlomaurizio

    2012-06-01

    The objective of this study was to evaluate the rates of previously undiagnosed rheumatic diseases during the first trimester of pregnancy and their impact on the pregnancy outcome. Pregnant women in their first trimester were screened using a two-step approach using a self-administered 10-item questionnaire and subsequent testing for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibodies, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and evaluation by a rheumatologist. Overall, the complications of pregnancy evaluated included fetal loss, pre-eclampsia, gestational diabetes, fetal growth restriction, delivery at less than 34 weeks, neonatal resuscitation and admission to the neonatal intensive care unit. Out of the 2458 women screened, the authors identified 62 (2.5%) women with previously undiagnosed undifferentiated connective tissue disease (UCTD) and 24 (0.98%) women with previously undiagnosed definite systemic rheumatic disease. The prevalences were seven (0.28%) for systemic lupus erythematosus and Sjogren's syndrome, six (0.24%) for rheumatoid arthritis, three (0.12%) for antiphospholipid syndrome and one (0.04%) for systemic sclerosis. In multiple exact logistic regression, after adjustment for potential confounders, the OR of overall complications of pregnancy were 2.81 (95% CI 1.29 to 6.18) in women with UCTD and 4.57 (95% CI 1.57 to 13.57) in those with definite diseases, respectively, compared with asymptomatic controls. In our population approximately 2.5% and 1% of first trimester pregnant women had a previously undiagnosed UCTD and definite systemic rheumatic disease, respectively. These conditions were associated with significant negative effects on the outcome of pregnancy.

  7. Shallow Faulting in Morelia, Mexico, Based on Seismic Tomography and Geodetically Detected Land Subsidence

    Science.gov (United States)

    Cabral-Cano, E.; Arciniega-Ceballos, A.; Vergara-Huerta, F.; Chaussard, E.; Wdowinski, S.; DeMets, C.; Salazar-Tlaczani, L.

    2013-12-01

    Subsidence has been a common occurrence in several cities in central Mexico for the past three decades. This process causes substantial damage to the urban infrastructure and housing in several cities and it is a major factor to be considered when planning urban development, land-use zoning and hazard mitigation strategies. Since the early 1980's the city of Morelia in Central Mexico has experienced subsidence associated with groundwater extraction in excess of natural recharge from rainfall. Previous works have focused on the detection and temporal evolution of the subsidence spatial distribution. The most recent InSAR analysis confirms the permanence of previously detected rapidly subsiding areas such as the Rio Grande Meander area and also defines 2 subsidence patches previously undetected in the newly developed suburban sectors west of Morelia at the Fraccionamiento Del Bosque along, south of Hwy. 15 and another patch located north of Morelia along Gabino Castañeda del Rio Ave. Because subsidence-induced, shallow faulting develops at high horizontal strain localization, newly developed a subsidence areas are particularly prone to faulting and fissuring. Shallow faulting increases groundwater vulnerability because it disrupts discharge hydraulic infrastructure and creates a direct path for transport of surface pollutants into the underlying aquifer. Other sectors in Morelia that have been experiencing subsidence for longer time have already developed well defined faults such as La Colina, Central Camionera, Torremolinos and La Paloma faults. Local construction codes in the vicinity of these faults define a very narrow swath along which housing construction is not allowed. In order to better characterize these fault systems and provide better criteria for future municipal construction codes we have surveyed the La Colina and Torremolinos fault systems in the western sector of Morelia using seismic tomographic techniques. Our results indicate that La Colina Fault

  8. HEART TRANSPLANTATION IN PATIENTS WITH PREVIOUS OPEN HEART SURGERY

    Directory of Open Access Journals (Sweden)

    R. Sh. Saitgareev

    2016-01-01

    Full Text Available Heart Transplantation (HTx to date remains the most effective and radical method of treatment of patients with end-stage heart failure. The defi cit of donor hearts is forcing to resort increasingly to the use of different longterm mechanical circulatory support systems, including as a «bridge» to the follow-up HTx. According to the ISHLT Registry the number of recipients underwent cardiopulmonary bypass surgery increased from 40% in the period from 2004 to 2008 to 49.6% for the period from 2009 to 2015. HTx performed in repeated patients, on the one hand, involves considerable technical diffi culties and high risks; on the other hand, there is often no alternative medical intervention to HTx, and if not dictated by absolute contradictions the denial of the surgery is equivalent to 100% mortality. This review summarizes the results of a number of published studies aimed at understanding the immediate and late results of HTx in patients, previously underwent open heart surgery. The effect of resternotomy during HTx and that of the specifi c features associated with its implementation in recipients previously operated on open heart, and its effects on the immediate and long-term survival were considered in this review. Results of studies analyzing the risk factors for perioperative complications in repeated recipients were also demonstrated. Separately, HTx risks after implantation of prolonged mechanical circulatory support systems were examined. The literature does not allow to clearly defi ning the impact factor of earlier performed open heart surgery on the course of perioperative period and on the prognosis of survival in recipients who underwent HTx. On the other hand, subject to the regular fl ow of HTx and the perioperative period the risks in this clinical situation are justifi ed as a long-term prognosis of recipients previously conducted open heart surgery and are comparable to those of patients who underwent primary HTx. Studies

  9. Incidence of previously undetected disease in routine paediatric otolaryngology admissions.

    Science.gov (United States)

    Zeitoun, H; Robinson, P

    1996-06-01

    The process of clerking routine pre-operative admissions involves the house officer taking a full medical history and performing a full physical examination. The diagnostic yield is thought to be low, and the educational value to the house officer is also small. This study addresses the question as to whether routine physical examination is always indicated. One hundred and nine children admitted for routine Otolaryngology procedures were prospectively studied to identify the importance of examination in the pre-operative assessment of patients. The results showed that 51 per cent of the children admitted had risk factors. The medical history was sufficient to identify these risk factors in all patients with the exception of one cardiac condition. This study concludes that a suitable alternative to the current process of clerking such as a standardized nurse history could be safely and efficiently undertaken. Eliminating the tiny percentage of previously unrecognized disease would be a prerequisite for such a change.

  10. Geodetic exploration of strain along the El Pilar Fault in northeastern Venezuela

    Science.gov (United States)

    Reinoza, C.; Jouanne, F.; Audemard, F. A.; Schmitz, M.; Beck, C.

    2015-03-01

    We use Global Navigation Satellite Systems observations in northeastern Venezuela to constrain the El Pilar Fault (EPF) kinematics and to explore the effects of the variable elastic properties of the surrounding medium and of the fault geometry on inferred slip rates and locking depth. The velocity field exhibits an asymmetric velocity gradient on either side of the EPF. We use five different approaches to explore possible models to explain this asymmetry. First, we infer a 1.6 km locking depth using a classic elastic half-space dislocation model. Second, we infer a 1.5 km locking depth and a 0.33 asymmetry coefficient using a heterogeneous asymmetric model, including contrasting material properties on either side of a vertical fault, suggesting that the igneous-metamorphic terranes on the northern side are ~2 times more rigid than the sedimentary southern side. Third, we use a three-dimensional elastostatic model to evaluate the presence of a compliant zone, suggesting a 30% reduction of rigidity in the upper 3 km at the depth of a 1 to 5 km wide fault zone. Fourth, we evaluate the distribution of fault slip, revealing a widespread partial creep pattern in the eastern upper segment, while the upper western segment exhibits a partially locked area, which coincides with the rupture surface of the 1797 and 1929 earthquakes. To supplement these models, we upgrade the previously published displacement simulation method using nonvertical dislocations with data acquired between 2003 and 2013. The localized aseismic displacement pattern associated with creeping or partially creeping fault segments could explain the low level of historic seismicity.

  11. Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004

    Directory of Open Access Journals (Sweden)

    N Dabiri

    2008-04-01

    Full Text Available ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent of the subjects and 19 people (47.5 percent of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.

  12. 22 CFR 40.91 - Certain aliens previously removed.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a result...

  13. Geodetic constraints on areal changes in the Pacific-North America plate boundary zone: What controls Basin and Range extension?

    Science.gov (United States)

    Kreemer, Corné; Hammond, William C.

    2007-10-01

    Using ˜1500 geodetic velocities we model the present-day spatial patterns of areal changes inside the Pacific-North America plate boundary zone. From this model we show that between the central Gulf of California and the Queen Charlotte Islands there is no significant net change in surface area. This zero net areal-change result allows us to relate regions of areal growth to areas of equivalent contraction elsewhere within the plate boundary zone. We find that areal growth of the Basin and Range province (BRP) and its eastern margin (˜5.2 ± 0.1 × 103 m2/yr) is balanced by areal reduction near northwestern California between 38°N and 42°N. The San Andreas fault system south of 38°N and the plate boundary zone north of ˜42°N (including the Juan de Fuca and Gorda Ridge systems) each have no significant net areal change. Our results suggest a kinematic relationship between extension in the BRP and contraction near the northern California Coast Ranges and Klamath Mountains. From these observations we propose that, although BRP extension may be caused by internal forces, the southernmost Cascadia subduction zone provides a “window of escape” that acts as a stress guide to BRP extension as well as northwestward Sierra Nevada motion. Such a dynamic model is consistent with independent findings that (1) the least principal horizontal stress orientations in the BRP are toward northern California, (2) extension directions in the BRP have changed orientation to track the northward migration of the Mendocino triple junction, and (3) the southernmost Cascadia subduction zone is a relatively weak plate boundary.

  14. Intravitreal ranibizumab for diabetic macular oedema in previously vitrectomized eyes

    DEFF Research Database (Denmark)

    Laugesen, Caroline Schmidt; Ostri, Christoffer; Brynskov, Troels

    2017-01-01

    PURPOSE: There is little information about the efficacy of intravitreal vascular endothelial growth factor (VEGF) inhibition in vitrectomized eyes. This study aimed to evaluate the efficacy of anti-VEGF (ranibizumab) on diabetic macular oedema in previously vitrectomized eyes. METHODS: A nationwide...... retrospective review of medical records from 2010 to 2013. RESULTS: We identified 33 previously vitrectomized eyes in 28 patients treated with ranibizumab injections for diabetic macular oedema. Median follow-up was 323 days (interquartile range 72-1404 days). Baseline mean visual acuity was 0.57 logMAR (95% CI...... 0.13-1.01) before injections. After an average of 4.7 injections (range 1-15), mean visual acuity remained stable at 0.54 logMAR (95% CI 0.13-0.95) with a mean improvement of 0.03 (p = 0. 45, 95% CI -0.12 to 0.06). In 12 eyes (36%), visual acuity improved 0.1 logMAR or more, in 12 eyes (36%), vision...

  15. Efforts to promote vaginal delivery after a previous cesarean section.

    Science.gov (United States)

    Hamai, Yoko; Imanishi, Yukio

    2012-01-01

    The aim of this study was to examine the results of vaginal delivery in patients with a past history of cesarean section. The type of delivery, interventions during delivery, and the prognoses of the mothers and babies were examined in 145 women with a history of cesarean section over the 10-year period from January 2000 to December 2009. A scheduled cesarean section was performed in 27 cases. Vaginal delivery was recommended in 118 cases and the success rate was 94.9% (112/118). Uterine rupture was observed in one patient who experienced a natural rupture at home and whose previous cesarean section was an inverse T incision. No cases required a blood transfusion or hysterectomy. The prognoses of both mothers and babies were good and the vaginal delivery success rate was 94.9%. Uterine rupture was observed in one case. Vaginal delivery with previous cesarean section should be considered in cases with expectation and informed consent. © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

  16. A new approach to the unrest and subsequent eruption at El Hierro Island (2011) based on petrological, seismological, geodetical and gravimetric data

    Science.gov (United States)

    Meletlidis, Stavros; Di Roberto, Alessio; Domínguez Cerdeña, Itahiza; Pompilio, Massimo; García-Cañada, Laura; Bertagnini, Antonella; Benito Saz, Maria Angeles; Del Carlo, Paola; Sainz-Maza Aparicio, Sergio; Lopez Moreno, Carmen; Moure García, David

    2014-05-01

    A shallow submarine eruption took place on 10th October 2011, about 1.8 km off the coast of La Restinga, a small village located in El Hierro (Canary Islands, Spain). The eruption lasted for about four months and ended by early March 2012. The eruption was preceded by an unrest episode that initiated about three months before, in July 2011, and characterized by more than 10,000 localized earthquakes accompanied by up to 5 cm of vertical ground deformation. In the Canary Islands, this event represents the first case of an eruption that was monitored since the unrest to the end by the monitoring network of IGN (Instituto Geográfico National), providing a huge dataset that includes geophysical (seismic, magnetic and gravimetric), geodetic, geochemistry and petrological data. In this work we use the seismic, GPS and gravity records collected by IGN along with the petrological data derived from the study of various lava balloons, scoriaceous fragments and ash.Geophysical and geochemical monitoring tools provide a variety of information that need to be interpreted in terms of magma movement and/or interaction of magma with host rocks. We present a model, based on this data, which describes the intrusion and ascent of the magma. According to this model, a major intrusion beneath and around preexisting high-density magmatic bodies, localized in the central sector of the island, led to an eruption in the Southern sector of the island. After a failed attempt to reach the surface, while various dykes were emplaced, through a low fractured area in the Central and Northern parts of the island, the ascending magma finally found its way in the submarine area of L