WorldWideScience

Sample records for previous geodetic studies

  1. Legacy and future of Kilauea's geodetic studies

    Science.gov (United States)

    Montgomery-Brown, E. D.; Miklius, A.

    2011-12-01

    Because of its extensive and detailed history of geodetic measurements, Kilauea is one of the best-studied if not also best-understood volcanic systems in the world. Hawaiian volcanoes have a long history of deformation observations. These observations range from native legends of Pele's underground travels, through initial measurements made by the Hawaiian Volcano Observatory, and finally to current ground-based and satellite observations. Many questions still remain, relating to Kilauea's dynamics, where geodetic measurements could offer fundamental insights. For example, new geodetic experiments could lead to a better understanding of the degree of magmatic and tectonic interaction, the geometries of faults at depth, the extent of offshore deformation, and the magmatic plumbing system. While it is possible to design many experiments to address these issues, we focus on three deformation targets where geodetic improvements, including finer sampling in space and time, could yield significant advancements toward understanding Kilauea's dynamics. First, by scrutinizing spatially-dense space-borne geodetic data for signs of upper east rift zone deformation and incorporating gravity and seismic data in a high resolution tomographic model, the hydraulic connection between Kilauea's summit and the rift zone could be imaged, which would provide insight into the pathways that transport magma out to the rift zones. Second, a combination of geodetic and seismic data could be used to determine the nature of possible relationships and interactions between the Hilina fault system and Kilauea's basal decollement. Such a study would have important implications for assessments of future earthquake and sector collapse hazards. Lastly, by adding seafloor geodetic measurements and seismic data to the current geodetic network on Kilauea, we could delimit the offshore extent of transient and episodic decollement deformation. In addition to multidisciplinary approaches, future geodetic

  2. Error Propagation in Geodetic Networks Studied by FEMLAB

    DEFF Research Database (Denmark)

    Borre, Kai

    2009-01-01

    Geodetic networks can be described by discrete models. The observations may be height differences, distances, and directions. Geodesists always make more observations than necessary and estimate the solution by using the principle of least squares. Contemporary networks often contain several thou...

  3. Geodetic Control Points - National Geodetic Survey Benchmarks

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  4. On the Tengiz petroleum deposit previous study

    International Nuclear Information System (INIS)

    Nysangaliev, A.N.; Kuspangaliev, T.K.

    1997-01-01

    Tengiz petroleum deposit previous study is described. Some consideration about structure of productive formation, specific characteristic properties of petroleum-bearing collectors are presented. Recommendation on their detail study and using of experience on exploration and development of petroleum deposit which have analogy on most important geological and industrial parameters are given. (author)

  5. A comparative study for the estimation of geodetic point velocity by ...

    Indian Academy of Sciences (India)

    Geodetic point velocity; artificial neural networks; back propagation; radial basis function; Kriging. J. Earth Syst. Sci. ...... The employment of BPANN is an alternative tool to KRIG for .... Computational Intelligence and Multimedia Applications.

  6. The Importance of Geodetically Controlled Data Sets: THEMIS Controlled Mosaics of Mars, a Case Study

    Science.gov (United States)

    Fergason, R. L.; Weller, L.

    2018-04-01

    Accurate image registration is necessary to answer questions that are key to addressing fundamental questions about our universe. To provide such a foundational product for Mars, we have geodetically controlled and mosaicked THEMIS IR images.

  7. NChina16: A stable geodetic reference frame for geological hazard studies in North China

    Science.gov (United States)

    Wang, Guoquan; Bao, Yan; Gan, Weijun; Geng, Jianghui; Xiao, Gengru; Shen, Jack S.

    2018-04-01

    We have developed a stable North China Reference Frame 2016 (NChina16) using five years of continuous GPS observations (2011.8-2016.8) from 12 continuously operating reference stations (CORS) fixed to the North China Craton. Applications of NChina16 in landslide and subsidence studies are illustrated in this article. A method for realizing a regional geodetic reference frame is introduced. The primary result of this study is the seven parameters for transforming Cartesian ECEF (Earth-Centered, Earth-Fixed) coordinates X, Y, and Z from the International GNSS Service Reference Frame 2008 (IGS08) to NChina16. The seven parameters include the epoch that is used to align the regional reference frame to IGS08 and the time derivatives of three translations and three rotations. The GIPSY-OASIS (V6.4) software package was used to obtain the precise point positioning (PPP) daily solutions with respect to IGS08. The frame stability of NChina16 is approximately 0.5 mm/year in both horizontal and vertical directions. This study also developed a regional model for correcting seasonal motions superimposed into the vertical component of the GPS-derived displacement time series. Long-term GPS observations (1999-2016) from five CORS in North China were used to develop the seasonal model. According to this study, the PPP daily solutions with respect to NChina16 could achieve 2-3 mm horizontal accuracy and 4-5 mm vertical accuracy after being modified by the regional model. NChina16 will be critical to study geodynamic problems in North China, such as earthquakes, faulting, subsidence, and landslides. The regional reference frame will be periodically updated every few years to mitigate degradation of the frame with time and be synchronized with the update of IGS reference frame.

  8. COORDINATE TRANSFORMATION USING FEATHERSTONE AND VANÍČEK PROPOSED APPROACH - A CASE STUDY OF GHANA GEODETIC REFERENCE NETWORK

    Directory of Open Access Journals (Sweden)

    Yao Yevenyo Ziggah

    2017-03-01

    Full Text Available Most developing countries like Ghana are yet to adopt the geocentric datum for its surveying and mapping purposes. It is well known and documented that non-geocentric datums based on its establishment have more distortions in height compared with satellite datums. Most authors have argued that combining such height with horizontal positions (latitude and longitude in the transformation process could introduce unwanted distortions to the network. This is because the local geodetic height in most cases is assumed to be determined to a lower accuracy compared with the horizontal positions. In the light of this, a transformation model was proposed by Featherstone and Vaníček (1999 which avoids the use of height in both global and local datums in coordinate transformation. It was confirmed that adopting such a method reduces the effect of distortions caused by geodetic height on the transformation parameters estimated. Therefore, this paper applied Featherstone and Vaníček (FV model for the first time to a set of common points coordinates in Ghana geodetic reference network. The FV model was used to transform coordinates from global datum (WGS84 to local datum (Accra datum. The results obtained based on the Root Mean Square Error (RMSE and Mean Absolute Error (MAE in both Eastings and Northings were satisfactory. Thus, a RMSE value of 0.66 m and 0.96 m were obtained for the Eastings and Northings while 0.76 m and 0.73 m were the MAE values achieved. Also, the FV model attained a transformation accuracy of 0.49 m. Hence, this study will serve as a preliminary investigation in avoiding the use of height in coordinate transformation within Ghana’s geodetic reference network.

  9. Modified geodetic brane cosmology

    International Nuclear Information System (INIS)

    Cordero, Rubén; Cruz, Miguel; Molgado, Alberto; Rojas, Efraín

    2012-01-01

    We explore the cosmological implications provided by the geodetic brane gravity action corrected by an extrinsic curvature brane term, describing a codimension-1 brane embedded in a 5D fixed Minkowski spacetime. In the geodetic brane gravity action, we accommodate the correction term through a linear term in the extrinsic curvature swept out by the brane. We study the resulting geodetic-type equation of motion. Within a Friedmann–Robertson–Walker metric, we obtain a generalized Friedmann equation describing the associated cosmological evolution. We observe that, when the radiation-like energy contribution from the extra dimension is vanishing, this effective model leads to a self-(non-self)-accelerated expansion of the brane-like universe in dependence on the nature of the concomitant parameter β associated with the correction, which resembles an analogous behaviour in the DGP brane cosmology. Several possibilities in the description for the cosmic evolution of this model are embodied and characterized by the involved density parameters related in turn to the cosmological constant, the geometry characterizing the model, the introduced β parameter as well as the dark-like energy and the matter content on the brane. (paper)

  10. New Antarctic Gravity Anomaly Grid for Enhanced Geodetic and Geophysical Studies in Antarctica.

    Science.gov (United States)

    Scheinert, M; Ferraccioli, F; Schwabe, J; Bell, R; Studinger, M; Damaske, D; Jokat, W; Aleshkova, N; Jordan, T; Leitchenkov, G; Blankenship, D D; Damiani, T M; Young, D; Cochran, J R; Richter, T D

    2016-01-28

    Gravity surveying is challenging in Antarctica because of its hostile environment and inaccessibility. Nevertheless, many ground-based, airborne and shipborne gravity campaigns have been completed by the geophysical and geodetic communities since the 1980s. We present the first modern Antarctic-wide gravity data compilation derived from 13 million data points covering an area of 10 million km 2 , which corresponds to 73% coverage of the continent. The remove-compute-restore technique was applied for gridding, which facilitated levelling of the different gravity datasets with respect to an Earth Gravity Model derived from satellite data alone. The resulting free-air and Bouguer gravity anomaly grids of 10 km resolution are publicly available. These grids will enable new high-resolution combined Earth Gravity Models to be derived and represent a major step forward towards solving the geodetic polar data gap problem. They provide a new tool to investigate continental-scale lithospheric structure and geological evolution of Antarctica.

  11. New Antarctic Gravity Anomaly Grid for Enhanced Geodetic and Geophysical Studies in Antarctica

    Science.gov (United States)

    Scheinert, M.; Ferraccioli, F.; Schwabe, J.; Bell, R.; Studinger, M.; Damaske, D.; Jokat, W.; Aleshkova, N.; Jordan, T.; Leitchenkov, G.; Blankenship, D. D.; Damiani, T. M.; Young, D.; Cochran, J. R.; Richter, T. D.

    2018-01-01

    Gravity surveying is challenging in Antarctica because of its hostile environment and inaccessibility. Nevertheless, many ground-based, airborne and shipborne gravity campaigns have been completed by the geophysical and geodetic communities since the 1980s. We present the first modern Antarctic-wide gravity data compilation derived from 13 million data points covering an area of 10 million km2, which corresponds to 73% coverage of the continent. The remove-compute-restore technique was applied for gridding, which facilitated levelling of the different gravity datasets with respect to an Earth Gravity Model derived from satellite data alone. The resulting free-air and Bouguer gravity anomaly grids of 10 km resolution are publicly available. These grids will enable new high-resolution combined Earth Gravity Models to be derived and represent a major step forward towards solving the geodetic polar data gap problem. They provide a new tool to investigate continental-scale lithospheric structure and geological evolution of Antarctica. PMID:29326484

  12. Analysis of geodetic and legal documentation in the process of expropriation for roads. Krakow case study

    Science.gov (United States)

    Trembecka, Anna

    2013-06-01

    Amendment to the Act on special rules of preparation and implementation of investment in public roads resulted in an accelerated mode of acquisition of land for the development of roads. The decision to authorize the execution of road investment issued on its basis has several effects, i.e. determines the location of a road, approves surveying division, approves construction design and also results in acquisition of a real property by virtue of law by the State Treasury or local government unit, among others. The conducted study revealed that over 3 years, in this mode, the city of Krakow has acquired 31 hectares of land intended for the implementation of road investments. Compensation is determined in separate proceedings based on an appraisal study estimating property value, often at a distant time after the loss of land by the owner. One reason for the lengthy compensation proceedings is challenging the proposed amount of compensation, unregulated legal status of the property as well as imprecise legislation. It is important to properly develop geodetic and legal documentation which accompanies the application for issuance of the decision and is also used in compensation proceedings. Zmiana ustawy o szczególnych zasadach przygotowywania i realizacji inwestycji w zakresie dróg publicznych spowodowała przyspieszony tryb pozyskiwania gruntów przeznaczonych pod budowę dróg. Wydawana na jej podstawie decyzja o zezwoleniu na realizację inwestycji drogowej wywołuje szereg skutków, tj. m.in. ustala lokalizację drogi, zatwierdza podziały geodezyjne, zatwierdza projekt budowlany a także powoduje nabycie nieruchomości z mocy prawa, przez Skarb Państwa lub jednostki samorządu terytorialnego. Przeprowadzone badania wykazały iż w powyższym trybie miasto Kraków nabyło w okresie 3 lat ponad 31 ha gruntów przeznaczonych na realizację inwestycji drogowych. Odszkodowanie ustalane jest w drodze odrębnego postępowania w oparciu o operat szacunkowy okre

  13. Personality disorders in previously detained adolescent females: a prospective study

    NARCIS (Netherlands)

    Krabbendam, A.; Colins, O.F.; Doreleijers, T.A.H.; van der Molen, E.; Beekman, A.T.F.; Vermeiren, R.R.J.M.

    2015-01-01

    This longitudinal study investigated the predictive value of trauma and mental health problems for the development of antisocial personality disorder (ASPD) and borderline personality disorder (BPD) in previously detained women. The participants were 229 detained adolescent females who were assessed

  14. Monitoring ground deformation of cultural heritage sites using UAVs and geodetic techniques: the case study of Choirokoitia, JPI PROTHEGO project

    Science.gov (United States)

    Themistocleous, Kyriacos; Danezis, Chris; Mendonidis, Evangelos; Lymperopoulou, Efstathia

    2017-10-01

    This paper presents the integrated methods using UAVs and geodetic techniques to monitor ground deformation within the Choirokoitia UNESCO World Heritage Site in Cyprus. The Neolithic settlement of Choirokoitia, occupied from the 7th to the 4th millennium B.C., is one of the most important prehistoric sites in the eastern Mediterranean. The study is conducted under the PROTHEGO (PROTection of European Cultural HEritage from GeO-hazards) project, which is a collaborative research project funded in the framework of the Joint Programming Initiative on Cultural Heritage and Global Change (JPICH) - Heritage Plus in 2015-2018 (www.prothego.eu) and through the Cyprus Research Promotion Foundation. PROTHEGO aims to make an innovative contribution towards the analysis of geo-hazards in areas of cultural heritage, and uses novel space technology based on radar interferometry to retrieve information on ground stability and motion in the 400+ UNESCO's World Heritage List monuments and sites of Europe. The field measurements collected at the Choirokoitia site will be later compared with SAR data to verify micro-movements in the area to monitor potential geo-hazards. The site is located on a steep hill, which makes it vulnerable to rock falls and landslides.

  15. Geodetic Survey Water Level Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Over one million images of National Coast & Geodetic Survey (now NOAA's National Geodetic Survey/NGS) forms captured from microfiche. Tabular forms and charts...

  16. Global deformation of the Earth, surface mass anomalies, and the geodetic infrastructure required to study these processes

    Science.gov (United States)

    Kusche, J.; Rietbroek, R.; Gunter, B.; Mark-Willem, J.

    2008-12-01

    Global deformation of the Earth can be linked to loading caused by mass changes in the atmosphere, the ocean and the terrestrial hydrosphere. World-wide geodetic observation systems like GPS, e.g., the global IGS network, can be used to study the global deformation of the Earth directly and, when other effects are properly modeled, provide information regarding the surface loading mass (e.g., to derive geo-center motion estimates). Vice versa, other observing systems that monitor mass change, either through gravitational changes (GRACE) or through a combination of in-situ and modeled quantities (e.g., the atmosphere, ocean or hydrosphere), can provide indirect information on global deformation. In the framework of the German 'Mass transport and mass distribution' program, we estimate surface mass anomalies at spherical harmonic resolution up to degree and order 30 by linking three complementary data sets in a least squares approach. Our estimates include geo-center motion and the thickness of a spatially uniform layer on top of the ocean surface (that is otherwise estimated from surface fluxes, evaporation and precipitation, and river run-off) as a time-series. As with all current Earth observing systems, each dataset has its own limitations and do not realize homogeneous coverage over the globe. To assess the impact that these limitations might have on current and future deformation and loading mass solutions, a sensitivity study was conducted. Simulated real-case and idealized solutions were explored in which the spatial distribution and quality of GPS, GRACE and OBP data sets were varied. The results show that significant improvements, e.g., over the current GRACE monthly gravity fields, in particular at the low degrees, can be achieved when these solutions are combined with present day GPS and OBP products. Our idealized scenarios also provide quantitative implications on how much surface mass change estimates may improve in the future when improved observing

  17. Aftershock distribution as a constraint on the geodetic model of coseismic slip for the 2004 Parkfield earthquake

    Science.gov (United States)

    Bennington, Ninfa; Thurber, Clifford; Feigl, Kurt; ,

    2011-01-01

    Several studies of the 2004 Parkfield earthquake have linked the spatial distribution of the event’s aftershocks to the mainshock slip distribution on the fault. Using geodetic data, we find a model of coseismic slip for the 2004 Parkfield earthquake with the constraint that the edges of coseismic slip patches align with aftershocks. The constraint is applied by encouraging the curvature of coseismic slip in each model cell to be equal to the negative of the curvature of seismicity density. The large patch of peak slip about 15 km northwest of the 2004 hypocenter found in the curvature-constrained model is in good agreement in location and amplitude with previous geodetic studies and the majority of strong motion studies. The curvature-constrained solution shows slip primarily between aftershock “streaks” with the continuation of moderate levels of slip to the southeast. These observations are in good agreement with strong motion studies, but inconsistent with the majority of published geodetic slip models. Southeast of the 2004 hypocenter, a patch of peak slip observed in strong motion studies is absent from our curvature-constrained model, but the available GPS data do not resolve slip in this region. We conclude that the geodetic slip model constrained by the aftershock distribution fits the geodetic data quite well and that inconsistencies between models derived from seismic and geodetic data can be attributed largely to resolution issues.

  18. Automated and dynamic scheduling for geodetic VLBI - A simulation study for AuScope and global networks

    Science.gov (United States)

    Iles, E. J.; McCallum, L.; Lovell, J. E. J.; McCallum, J. N.

    2018-02-01

    As we move into the next era of geodetic VLBI, the scheduling process is one focus for improvement in terms of increased flexibility and the ability to react with changing conditions. A range of simulations were conducted to ascertain the impact of scheduling on geodetic results such as Earth Orientation Parameters (EOPs) and station coordinates. The potential capabilities of new automated scheduling modes were also simulated, using the so-called 'dynamic scheduling' technique. The primary aim was to improve efficiency for both cost and time without losing geodetic precision, particularly to maximise the uses of the Australian AuScope VLBI array. We show that short breaks in observation will not significantly degrade the results of a typical 24 h experiment, whereas simply shortening observing time degrades precision exponentially. We also confirm the new automated, dynamic scheduling mode is capable of producing the same standard of result as a traditional schedule, with close to real-time flexibility. Further, it is possible to use the dynamic scheduler to augment the 3 station Australian AuScope array and thereby attain EOPs of the current global precision with only intermittent contribution from 2 additional stations. We thus confirm automated, dynamic scheduling bears great potential for flexibility and automation in line with aims for future continuous VLBI operations.

  19. A Comparative Study of the Applied Methods for Estimating Deflection of the Vertical in Terrestrial Geodetic Measurements

    Directory of Open Access Journals (Sweden)

    Luca Vittuari

    2016-04-01

    Full Text Available This paper compares three different methods capable of estimating the deflection of the vertical (DoV: one is based on the joint use of high precision spirit leveling and Global Navigation Satellite Systems (GNSS, a second uses astro-geodetic measurements and the third gravimetric geoid models. The working data sets refer to the geodetic International Terrestrial Reference Frame (ITRF co-location sites of Medicina (Northern, Italy and Noto (Sicily, these latter being excellent test beds for our investigations. The measurements were planned and realized to estimate the DoV with a level of precision comparable to the angular accuracy achievable in high precision network measured by modern high-end total stations. The three methods are in excellent agreement, with an operational supremacy of the astro-geodetic method, being faster and more precise than the others. The method that combines leveling and GNSS has slightly larger standard deviations; although well within the 1 arcsec level, which was assumed as threshold. Finally, the geoid model based method, whose 2.5 arcsec standard deviations exceed this threshold, is also statistically consistent with the others and should be used to determine the DoV components where local ad hoc measurements are lacking.

  20. Radon anomalies prior to earthquakes (1). Review of previous studies

    International Nuclear Information System (INIS)

    Ishikawa, Tetsuo; Tokonami, Shinji; Yasuoka, Yumi; Shinogi, Masaki; Nagahama, Hiroyuki; Omori, Yasutaka; Kawada, Yusuke

    2008-01-01

    The relationship between radon anomalies and earthquakes has been studied for more than 30 years. However, most of the studies dealt with radon in soil gas or in groundwater. Before the 1995 Hyogoken-Nanbu earthquake, an anomalous increase of atmospheric radon was observed at Kobe Pharmaceutical University. The increase was well fitted with a mathematical model related to earthquake fault dynamics. This paper reports the significance of this observation, reviewing previous studies on radon anomaly before earthquakes. Groundwater/soil radon measurements for earthquake prediction began in 1970's in Japan as well as foreign countries. One of the most famous studies in Japan is groundwater radon anomaly before the 1978 Izu-Oshima-kinkai earthquake. We have recognized the significance of radon in earthquake prediction research, but recently its limitation was also pointed out. Some researchers are looking for a better indicator for precursors; simultaneous measurements of radon and other gases are new trials in recent studies. Contrary to soil/groundwater radon, we have not paid much attention to atmospheric radon before earthquakes. However, it might be possible to detect precursors in atmospheric radon before a large earthquake. In the next issues, we will discuss the details of the anomalous atmospheric radon data observed before the Hyogoken-Nanbu earthquake. (author)

  1. Geodetic achievement and avoidance games for graphs | Haynes ...

    African Journals Online (AJOL)

    Let G = (V,E) be a nontrivial connected graph. For a subset S ⊆ V, the geodesic closure (S) of S is the set of all vertices on geodesics (shortest paths) between two vertices of S. We study the geodetic achievement and avoidance games defined by Buckley and Harary (Geodetic games for graphs, Quaestiones Math.

  2. Geodesy introduction to geodetic datum and geodetic systems

    CERN Document Server

    Lu, Zhiping; Qiao, Shubo

    2014-01-01

    A full introduction to geodetic data and systems written by well-known experts in their respective fields, this book is an ideal text for courses in geodesy and geomatics covering everything from coordinate and gravimetry data to geodetic systems of all types.

  3. Integration of space geodesy: A US National Geodetic Observatory

    Science.gov (United States)

    Yunck, Thomas P.; Neilan, Ruth E.

    2005-11-01

    In the interest of improving the performance and efficiency of space geodesy a diverse group in the US, in collaboration with IGGOS, has begun to establish a unified National Geodetic Observatory (NGO). To launch this effort an international team will conduct a multi-year program of research into the technical issues of integrating SLR, VLBI, and GPS geodesy to produce a unified set of global geodetic products. The goal is to improve measurement accuracy by up to an order of magnitude while lowering the cost to current sponsors. A secondary goal is to expand and diversify international sponsorship of space geodesy. Principal benefits will be to open new vistas of research in geodynamics and surface change while freeing scarce NASA funds for scientific studies. NGO will proceed in partnership with, and under the auspices of, the International Association of Geodesy (IAG) as an element of the Integrated Global Geodetic Observation System project. The collaboration will be conducted within, and will make full use of, the IAG's existing international services: the IGS, IVS, ILRS, and IERS. Seed funding for organizational activities and technical analysis will come from NASA's Solid Earth and Natural Hazards Program. Additional funds to develop an integrated geodetic data system known as Inter-service Data Integration for Geodetic Operations (INDIGO), will come from a separate NASA program in Earth science information technology. INDIGO will offer ready access to the full variety of NASA's space geodetic data and will extend the GPS Seamless Archive (GSAC) philosophy to all space geodetic data types.

  4. A preliminary geodetic data model for geographic information systems

    Science.gov (United States)

    Kelly, K. M.

    2009-12-01

    Our ability to gather and assimilate integrated data collections from multiple disciplines is important for earth system studies. Moreover, geosciences data collection has increased dramatically, with pervasive networks of observational stations on the ground, in the oceans, in the atmosphere and in space. Contemporary geodetic observations from several space and terrestrial technologies contribute to our knowledge of earth system processes and thus are a valuable source of high accuracy information for many global change studies. Assimilation of these geodetic observations and numerical models into models of weather, climate, oceans, hydrology, ice, and solid Earth processes is an important contribution geodesists can make to the earth science community. Clearly, the geodetic observations and models are fundamental to these contributions. ESRI wishes to provide leadership in the geodetic community to collaboratively build an open, freely available content specification that can be used by anyone to structure and manage geodetic data. This Geodetic Data Model will provide important context for all geographic information. The production of a task-specific geodetic data model involves several steps. The goal of the data model is to provide useful data structures and best practices for each step, making it easier for geodesists to organize their data and metadata in a way that will be useful in their data analyses and to their customers. Built on concepts from the successful Arc Marine data model, we introduce common geodetic data types and summarize the main thematic layers of the Geodetic Data Model. These provide a general framework for envisioning the core feature classes required to represent geodetic data in a geographic information system. Like Arc Marine, the framework is generic to allow users to build workflow or product specific geodetic data models tailored to the specific task(s) at hand. This approach allows integration of the data with other existing

  5. National Geodetic Survey (NGS) Geodetic Control Stations, (Horizontal and/or Vertical Control), March 2009

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  6. National Geodetic Control Stations, Geographic NAD83, NGS (2004) [geodetic_ctrl_point_la_NGS_2004

    Data.gov (United States)

    Louisiana Geographic Information Center — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  7. Geodetic and seismological investigation in the Ionian area

    Directory of Open Access Journals (Sweden)

    F. Riguzzi

    1997-06-01

    Full Text Available Geodetic and seismic evidence of crustal deformations in the Ionian area are shown in this paper. The Ionian GPS network, composed of nine sites crossing the Ionian Sea from Calabria, Southern Italy, to Northwestern Greece, was established and surveyed in 1991, 1994, 1995 within the framework of the TYRGEONET project (Anzidei et al., 1996. In 1996 a return campaign was carried out after the occurrence of seismic activity in 1995. The displacement pattern obtained for the Greek side of the network agrees well with those previously displayed, both in magnitude and direction, confirming a mean displacement rate of about 1-2 cm1/yr. The same agreement is not found for the Italian side of the network, where no significant deformations were detected between 1994 and 1996. Seismic deformation was also studied for the same area, starting from the moment tensors of events which occurred in the last 20 years with magnitude greater than 5.0; evident similarity with the displacement field exhibited by the Greek side of the Ionian Sea by geodetic surveys was inferred. On the contrary, the motion detected for the Italian area cannot be simply related to seismic activity.

  8. National Geodetic Survey's Airport Aerial Photography

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Geodetic Survey (NGS), formerly part of the U.S. Coast and Geodetic Survey, has been performing Aeronautical surveys since the 1920's. NGS, in...

  9. An integrated geodetic and seismic study of the Cusco Fault system in the Cusco Region-Southern Peru

    Science.gov (United States)

    Norabuena, E. O.; Tavera, H. J.

    2017-12-01

    The Cusco Fault system is composed by six main faults (Zurite, Tamboray, Qoricocha, Tambomachay, Pachatusan, and Urcos) extending in a NW-SE direction over the Cusco Region in southeastern Peru. From these, the Tambomachay is a normal fault of 20 km length, strikes N120°E and bounds a basin filled with quaternary lacustrine and fluvial deposits. Given its 5 km distance to Cusco, an historical and Inca's archeological landmark, it represents a great seismic hazard for its more than 350,000 inhabitants. The Tambomachay fault as well as the other secondary faults have been a source of significant seismic activity since historical times being the more damaging ones the Cusco earthquakes of 1650, 1950 and more recently April 1986 (M 5.8). Previous geological studies indicate that at the beginning of the Quaternary the fault showed a transcurrent mechanism leading to the formation of the Cusco basin. However, nowadays its mechanism is normal fault and scarps up to 22m can be observed. We report the current dynamics of the Tambomachay fault and secondary faults based on seismic activity imaged by a network of 29 broadband stations deployed in the Cusco Region as well as the deformation field inferred from GPS survey measurements carried out between 2014 and 2016.

  10. Is the Okavango Delta the terminus of the East African Rift System? Towards a new geodynamic model: Geodetic study and geophysical review

    Science.gov (United States)

    Pastier, Anne-Morwenn; Dauteuil, Olivier; Murray-Hudson, Michael; Moreau, Frédérique; Walpersdorf, Andrea; Makati, Kaelo

    2017-08-01

    The Okavango Graben (OG) has been considered as the terminus of the southwestern branch of the East African Rift System (EARS) since the 1970s based on fault morphology and early seismic and geophysical data. Thus it has been assumed to be an incipient rifting zone, analogous to the early stage of mature rifts in the EARS. Recent geodetic data and geophysical studies in the area bring new insights into the local crust and lithosphere, mantle activity and fault activity. In this study, we computed the velocities for three permanent GPS stations surrounding the graben and undertook a review of the new geophysical data available for the area. The northern and southern blocks of the graben show an exclusively low strike-slip displacement rate of about 1mm/year, revealing the transtensional nature of this basin. The seismic record of central and southern Africa was found to be instrumentally biased for the events recorded before 2004 and the OG may not represent the most seismically active area in Botswana anymore. Moreover, no significant lithosphere and crustal thinning is found in the tectonic structure nor any strong negative Bouguer anomaly and surface heat flux. Thus the OG does not match the classical model for a rifting zone. We propose a new geodynamic model for the deformation observed west of the EARS based on accommodation of far-field deformation due to the differential extension rates of the EARS and the displacement of the Kalahari craton relative to the Nubian plate.

  11. Added-value joint source modelling of seismic and geodetic data

    Science.gov (United States)

    Sudhaus, Henriette; Heimann, Sebastian; Walter, Thomas R.; Krueger, Frank

    2013-04-01

    In tectonically active regions earthquake source studies strongly support the analysis of the current faulting processes as they reveal the location and geometry of active faults, the average slip released or more. For source modelling of shallow, moderate to large earthquakes often a combination of geodetic (GPS, InSAR) and seismic data is used. A truly joint use of these data, however, usually takes place only on a higher modelling level, where some of the first-order characteristics (time, centroid location, fault orientation, moment) have been fixed already. These required basis model parameters have to be given, assumed or inferred in a previous, separate and highly non-linear modelling step using one of the these data sets alone. We present a new earthquake rupture model implementation that realizes a fully combined data integration of surface displacement measurements and seismic data in a non-linear optimization of simple but extended planar ruptures. The model implementation allows for fast forward calculations of full seismograms and surface deformation and therefore enables us to use Monte Carlo global search algorithms. Furthermore, we benefit from the complementary character of seismic and geodetic data, e. g. the high definition of the source location from geodetic data and the sensitivity of the resolution of the seismic data on moment releases at larger depth. These increased constraints from the combined dataset make optimizations efficient, even for larger model parameter spaces and with a very limited amount of a priori assumption on the source. A vital part of our approach is rigorous data weighting based on the empirically estimated data errors. We construct full data error variance-covariance matrices for geodetic data to account for correlated data noise and also weight the seismic data based on their signal-to-noise ratio. The estimation of the data errors and the fast forward modelling opens the door for Bayesian inferences of the source

  12. Geodetic Control Information on Passive Marks: Horizontal and Vertical Geodetic Control Data for the United States - National Geospatial Data Asset (NGDA) Geodetic Control Information on Passive Marks

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data contains a set of geodetic control stations maintained by the National Geodetic Survey. Each geodetic control station in this dataset has either a precise...

  13. Use of Geodetic Surveys of Leveling Lines and Dry Tilt Arrays to Study Faults and Volcanoes in Undergraduate Field Geophysics Classes

    Science.gov (United States)

    Polet, J.; Alvarez, K.; Elizondo, K.

    2017-12-01

    In the early 1980's and 1990's numerous leveling lines and dry tilt arrays were installed throughout Central and Southern California by United States Geological Survey scientists and other researchers (e.g. Sylvester, 1985). These lines or triangular arrays of geodetic monuments commonly straddle faults or have been installed close to volcanic areas, where significant motion is expected over relatively short time periods. Over the past year, we have incorporated geodetic surveys of these arrays as part of our field exercises in undergraduate and graduate level classes on topics such as shallow subsurface geophysics and field geophysics. In some cases, the monuments themselves first had to be located based on only limited information, testing students' Brunton use and map reading skills. Monuments were then surveyed using total stations and global navigation satellite system (GNSS) receivers, using a variety of experimental procedures. The surveys were documented with tables, photos, maps and graphs in field reports, as well as in wiki pages created by student groups for a geophysics field class this June. The measurements were processed by the students and compared with similar data from surveys conducted soon after installation of the arrays, to analyze the deformation that occurred over the last few decades. The different geodetic techniques were also compared and an error analysis was conducted. The analysis and processing of these data challenged and enhanced students' quantitative literacy and technology skills. The final geodetic measurements are being incorporated into several senior and MSc thesis projects. Further surveys are planned for additional classes, in topics that could include seismology, geodesy, volcanology and global geophysics. We are also considering additional technologies, such as structure from motion (SfM) photogrammetry.

  14. Is Nubia plate rigid? A geodetic study of the relative motion of different cratonic areas within Africa.

    Science.gov (United States)

    Njoroge, M. W.; Malservisi, R.; Hugentobler, U.; Mokhtari, M.; Voytenko, D.

    2014-12-01

    Plate rigidity is one of the main paradigms of plate tectonics and a fundamental assumption in the definition of a global reference frame as ITRF. Although still far for optimal, the increased GPS instrumentation of the African region can allow us to understand how rigid one of the major plate can be. The presence of diffused band of seismicity, the Cameroon volcanic line, Pan African Kalahari orogenic belt and East Africa Rift suggest the possibility of relative motion among the different regions within the Nubia. The study focuses on the rigidity of Nubia plate. We divide the plate into three regions: Western (West Africa craton plus Nigeria), Central (approximately the region of the Congo craton) and Southern (Kalahari craton plus South Africa) and we utilize Euler Vector formulation to study internal rigidity and eventual relative motion. Developing five different reference frames with different combinations of the 3 regions, we try to understand the presence of the relative motion between the 3 cratons thus the stability of the Nubia plate as a whole. All available GPS stations from the regions are used separately or combined in creation of the reference frames. We utilize continuous stations with at least 2.5 years of data between 1994 and 2014. Given the small relative velocity, it is important to eliminate eventual biases in the analysis and to have a good estimation in the uncertainties of the observed velocities. For this reason we perform our analysis using both Bernese and Gipsy-oasis codes to generate time series for each station. Velocities and relative uncertainties are analyzed using the Allan variance of rate technique, taking in account for colored noise. An analysis of the color of the noise as function of latitude and climatic region is also performed to each time series. Preliminary results indicate a slight counter clockwise motion of West Africa craton with respect to South Africa Kalahari, and South Africa Kalahari-Congo Cratons. In addition

  15. Inter-Rifting and Inter-Seismic Strain Accumulation in a Propagating Ridge System: A Geodetic Study from South Iceland

    Science.gov (United States)

    Travis, M. E.; La Femina, P. C.; Geirsson, H.

    2012-12-01

    The Mid-Atlantic Ridge, a slow spreading (~19 mm/yr) mid-ocean ridge boundary between the North American and Eurasian plates, is exposed subaerially in Iceland as the result of ridge-hotspot interaction. Plate spreading in Iceland is accommodated along neovolcanic zones comprised of central volcanoes and their fissure swarms. In south Iceland plate motion is partitioned between the Western Volcanic Zone (WVZ) and Eastern Volcanic Zone (EVZ). The EVZ is propagating to the southwest, while the WVZ is dying out from the northeast. Plate motion across both systems has been accommodated by repeated rifting events and fissure eruptions. In this study we investigate whether the WVZ is active and accumulating strain, and how strain is partitioned between the WVZ and EVZ. We also test how strain is accumulating along fissure swarms within the EVZ (i.e. is strain accumulation localized to one fissure swarm, or are multiple systems active?). We use GPS data and elastic block models run using the program DEFNODE to investigate these issues. GPS data are processed using the GIPSY-OASIS II software, and have been truncated to the 2000.5-2011 time period to avoid co-seismic displacement from the two June 2000 South Iceland Seismic Zone earthquakes. We also truncate the time series for sites within 20 km of Eyjafjallajökull to the beginning of 2010 to eliminate deformation associated with the March 2010 eruption of that volcano. We correct for co-seismic displacement from the two May 2008 SISZ earthquakes, inflation at Hekla volcano and the horizontal component of glacial isostatic rebound (GIA). Our best-fit model for inter-rifting and inter-seismic elastic strain accumulation suggests 80-90% of spreading is accommodated in the EVZ with the other 10-20% accommodated by the WVZ. The best-fit location of the EVZ is between Veidivotn and Lakigigar in an area of no Holocene volcanic activity. We suggest the WVZ is only active at Hengill and its associated fissure swarm. Geologic and

  16. 40 CFR 152.93 - Citation of a previously submitted valid study.

    Science.gov (United States)

    2010-07-01

    ... Data Submitters' Rights § 152.93 Citation of a previously submitted valid study. An applicant may demonstrate compliance for a data requirement by citing a valid study previously submitted to the Agency. The... the original data submitter, the applicant may cite the study only in accordance with paragraphs (b...

  17. The Global Geodetic Observing System: Recent Activities and Accomplishments

    Science.gov (United States)

    Gross, R. S.

    2017-12-01

    The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) provides the basis on which future advances in geosciences can be built. By considering the Earth system as a whole (including the geosphere, hydrosphere, cryosphere, atmosphere and biosphere), monitoring Earth system components and their interactions by geodetic techniques and studying them from the geodetic point of view, the geodetic community provides the global geosciences community with a powerful tool consisting mainly of high-quality services, standards and references, and theoretical and observational innovations. The mission of GGOS is: (a) to provide the observations needed to monitor, map and understand changes in the Earth's shape, rotation and mass distribution; (b) to provide the global frame of reference that is the fundamental backbone for measuring and consistently interpreting key global change processes and for many other scientific and societal applications; and (c) to benefit science and society by providing the foundation upon which advances in Earth and planetary system science and applications are built. The goals of GGOS are: (1) to be the primary source for all global geodetic information and expertise serving society and Earth system science; (2) to actively promote, sustain, improve, and evolve the integrated global geodetic infrastructure needed to meet Earth science and societal requirements; (3) to coordinate with the international geodetic services that are the main source of key parameters and products needed to realize a stable global frame of reference and to observe and study changes in the dynamic Earth system; (4) to communicate and advocate the benefits of GGOS to user communities, policy makers, funding organizations, and society. In order to accomplish its mission and goals, GGOS depends on the IAG Services, Commissions, and Inter-Commission Committees. The Services provide the infrastructure and products on which all contributions

  18. Leveraging geodetic data to reduce losses from earthquakes

    Science.gov (United States)

    Murray, Jessica R.; Roeloffs, Evelyn A.; Brooks, Benjamin A.; Langbein, John O.; Leith, William S.; Minson, Sarah E.; Svarc, Jerry L.; Thatcher, Wayne R.

    2018-04-23

    Seismic hazard assessments that are based on a variety of data and the best available science, coupled with rapid synthesis of real-time information from continuous monitoring networks to guide post-earthquake response, form a solid foundation for effective earthquake loss reduction. With this in mind, the Earthquake Hazards Program (EHP) of the U.S. Geological Survey (USGS) Natural Hazards Mission Area (NHMA) engages in a variety of undertakings, both established and emergent, in order to provide high quality products that enable stakeholders to take action in advance of and in response to earthquakes. Examples include the National Seismic Hazard Model (NSHM), development of tools for improved situational awareness such as earthquake early warning (EEW) and operational earthquake forecasting (OEF), research about induced seismicity, and new efforts to advance comprehensive subduction zone science and monitoring. Geodetic observations provide unique and complementary information directly relevant to advancing many aspects of these efforts (fig. 1). EHP scientists have long leveraged geodetic data for a range of influential studies, and they continue to develop innovative observation and analysis methods that push the boundaries of the field of geodesy as applied to natural hazards research. Given the ongoing, rapid improvement in availability, variety, and precision of geodetic measurements, considering ways to fully utilize this observational resource for earthquake loss reduction is timely and essential. This report presents strategies, and the underlying scientific rationale, by which the EHP could achieve the following outcomes: The EHP is an authoritative source for the interpretation of geodetic data and its use for earthquake loss reduction throughout the United States and its territories.The USGS consistently provides timely, high quality geodetic data to stakeholders.Significant earthquakes are better characterized by incorporating geodetic data into USGS

  19. The evidences of progressive pressurization of volcanic conduit as driving forces of unrest phenomena analyzed via modelling of multiplatform geodetic measurements: Fernandina (GALAPAGOS) and Maunaloa (HAWAII) case studies

    Science.gov (United States)

    Pepe, Susi; Castaldo, Raffaele; Casu, Francesco; D'Auria, Luca; De Luca, Claudio; De Novellis, Vincenzo; Solaro, Giuseppe; Tizzani, Pietro

    2017-04-01

    collection, we determined the source responsible of deformation observed and in particular the results of our inversions show that the pipe source contributes substantially to both the ground deformation pattern and the cost function. In the case of Fernandina Volcano (Galápagos) we exploited the advanced Differential SAR Interferometry (DInSAR) techniques to analyze the 2012-2013 uplift episode by using X-band data from the COSMO-SkyMed (CSK) satellite constellation. This volcano falls among those not well monitored, therefore, the availability of CSK data, acquired with a repeat time ranging from 4 to 12 days and with a ground resolution of 3 meters, represents a unique opportunity to perform a detailed study of the space and time ground deformation field changes (Sansosti et al., 2014). In addition, in this case study we computed the ground deformation time series by applying the Small BAseline Subset (SBAS)-DInSAR approach (Berardino et al., 2002) to CSK data, acquired from both ascending and descending orbits. The results of their combination (vertical and horizontal E-W components) are used in order to evaluate, through a cross correlation analysis (Tizzani et al., 2009; 2015), the volcanic areas that are characterized by similar uplift temporal behavior. Subsequently, we determine the geometry, location and the temporal evolution of the geodetic source responsible for the 2012 - 2013 uplift event by applying an inverse method to the DInSAR measurements. We search for its geometrical parameters and volume variation that minimize the difference between the observed data and the modelled ground deformation field. We tested various analytical models and finally, using the Akaike Information Criterion (Akaike, 1965) among the tested analytical sources, we selected the tilted pipe. The pipe model is similar to the prolate ellipsoid, but the size of the smaller axis is kept fixed to a very small value (i.e., 10 m). Despite having a similar fit with the prolate ellipsoid

  20. Shallow Chamber & Conduit Behavior of Silicic Magma: A Thermo- and Fluid- Dynamic Parameterization Model of Physical Deformation as Constrained by Geodetic Observations: Case Study; Soufriere Hills Volcano, Montserrat

    Science.gov (United States)

    Gunn de Rosas, C. L.

    2013-12-01

    The Soufrière Hills Volcano, Montserrat (SHV) is an active, mainly andesitic and well-studied stratovolcano situated at the northern end of the Lesser Antilles Arc subduction zone in the Caribbean Sea. The goal of our research is to create a high resolution 3D subsurface model of the shallow and deeper aspects of the magma storage and plumbing system at SHV. Our model will integrate inversions using continuous and campaign geodetic observations at SHV from 1995 to the present as well as local seismic records taken at various unrest intervals to construct a best-fit geometry, pressure point source and inflation rate and magnitude. We will also incorporate a heterogeneous media in the crust and use the most contemporary understanding of deep crustal- or even mantle-depth 'hot-zone' genesis and chemical evolution of silicic and intermediate magmas to inform the character of the deep edifice influx. Our heat transfer model will be constructed with a modified 'thin shell' enveloping the magma chamber to simulate the insulating or conducting influence of heat-altered chamber boundary conditions. The final forward model should elucidate observational data preceding and proceeding unrest events, the behavioral suite of magma transport in the subsurface environment and the feedback mechanisms that may contribute to eruption triggering. Preliminary hypotheses suggest wet, low-viscosity residual melts derived from 'hot zones' will ascend rapidly to shallower stall-points and that their products (eventually erupted lavas as well as stalled plutonic masses) will experience and display two discrete periods of shallow evolution; a rapid depressurization crystallization event followed by a slower conduction-controlled heat transfer and cooling crystallization. These events have particular implications for shallow magma behaviors, notably inflation, compressibility and pressure values. Visualization of the model with its inversion constraints will be affected with Com

  1. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  2. Matched cohort study of external cephalic version in women with previous cesarean delivery.

    Science.gov (United States)

    Keepanasseril, Anish; Anand, Keerthana; Soundara Raghavan, Subrahmanian

    2017-07-01

    To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included. Characteristics and outcomes were compared between groups. ECV was successful for 32 (84.2%) of 38 women with previous cesarean delivery and 62 (81.6%) in the control group (P=0.728). Multivariate regression analysis confirmed that previous cesarean was not associated with ECV success (odds ratio 1.89, 95% confidence interval 0.19-18.47; P=0.244). Successful vaginal delivery after successful ECV was reported for 19 (59.4%) women in the previous cesarean delivery group and 52 (83.9%) in the control group (P<0.001). No ECV-associated complications occurred in women with previous cesarean delivery. To avoid a repeat cesarean delivery, ECV can be offered to women with breech presentation and previous cesarean delivery who are otherwise eligible for a trial of labor. © 2017 International Federation of Gynecology and Obstetrics.

  3. Investigating Strain Transfer Along the Southern San Andreas Fault: A Geomorphic and Geodetic Study of Block Rotation in the Eastern Transverse Ranges, Joshua Tree National Park, CA

    Science.gov (United States)

    Guns, K. A.; Bennett, R. A.; Blisniuk, K.

    2017-12-01

    To better evaluate the distribution and transfer of strain and slip along the Southern San Andreas Fault (SSAF) zone in the northern Coachella valley in southern California, we integrate geological and geodetic observations to test whether strain is being transferred away from the SSAF system towards the Eastern California Shear Zone through microblock rotation of the Eastern Transverse Ranges (ETR). The faults of the ETR consist of five east-west trending left lateral strike slip faults that have measured cumulative offsets of up to 20 km and as low as 1 km. Present kinematic and block models present a variety of slip rate estimates, from as low as zero to as high as 7 mm/yr, suggesting a gap in our understanding of what role these faults play in the larger system. To determine whether present-day block rotation along these faults is contributing to strain transfer in the region, we are applying 10Be surface exposure dating methods to observed offset channel and alluvial fan deposits in order to estimate fault slip rates along two faults in the ETR. We present observations of offset geomorphic landforms using field mapping and LiDAR data at three sites along the Blue Cut Fault and one site along the Smoke Tree Wash Fault in Joshua Tree National Park which indicate recent Quaternary fault activity. Initial results of site mapping and clast count analyses reveal at least three stages of offset, including potential Holocene offsets, for one site along the Blue Cut Fault, while preliminary 10Be geochronology is in progress. This geologic slip rate data, combined with our new geodetic surface velocity field derived from updated campaign-based GPS measurements within Joshua Tree National Park will allow us to construct a suite of elastic fault block models to elucidate rates of strain transfer away from the SSAF and how that strain transfer may be affecting the length of the interseismic period along the SSAF.

  4. Stability of Global Geodetic Results

    Science.gov (United States)

    Herring, T.

    The precision of global geodetic techniques has reached unprecedented levels. Sys- tems capable of millimeter level horizontal and several millimeter vertical precisions are now deployed. The Global Positioning System (GPS) has the most deployed continuously-operating receivers with several hundred providing data through the in- ternet for analysis. However, the satellite system used with GPS evolves with time as new generations of GPS satellites are launched. During the 1990's, the constellation evolved from Block I to Block II and IIA with the most recent generation being Block IIR. There are considerable differences in the size and antenna configurations in the different generations of satellites. The antenna configuration specifically could cause systematic changes in the terrestrial reference system. Results from the ITRF2000 combinations suggest that there are significant time variations in the scale of GPS system possibly due to phase center variations in GPS transmission antennas. These variations could result in height changes of up to 3 mm/yr. We will investigate the stability of the GPS system through combination of GPS results with results from VLBI and SLR. All components of the transformation between the systems, rotation, translation and scale will be investigated.

  5. An Overview of Geodetic Volcano Research in the Canary Islands

    Science.gov (United States)

    Fernández, José; González, Pablo J.; Camacho, Antonio G.; Prieto, Juan F.; Brú, Guadalupe

    2015-11-01

    The Canary Islands are mostly characterized by diffuse and scattered volcanism affecting a large area, with only one active stratovolcano, the Teide-Pico Viejo complex (Tenerife). More than 2 million people live and work in the 7,447 km2 of the archipelago, resulting in an average population density three times greater than the rest of Spain. This fact, together with the growth of exposure during the past 40 years, increases volcanic risk with respect previous eruptions, as witnessed during the recent 2011-2012 El Hierro submarine eruption. Therefore, in addition to purely scientific reasons there are economic and population-security reasons for developing and maintaining an efficient volcano monitoring system. In this scenario geodetic monitoring represents an important part of the monitoring system. We describe volcano geodetic monitoring research carried out in the Canary Islands and the results obtained. We consider for each epoch the two main existing constraints: the level of volcanic activity in the archipelago, and the limitations of the techniques available at the time. Theoretical and observational aspects are considered, as well as the implications for operational volcano surveillance. Current challenges of and future perspectives in geodetic volcano monitoring in the Canaries are also presented.

  6. Study of some physical aspects previous to design of an exponential experiment

    International Nuclear Information System (INIS)

    Caro, R.; Francisco, J. L. de

    1961-01-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs

  7. Study of functional-performance deficits in athletes with previous ankle sprains

    Directory of Open Access Journals (Sweden)

    hamid Babaee

    2008-04-01

    Full Text Available Abstract Background: Despite the importance of functional-performance deficits in athletes with history of ankle sprain few, studies have been carried out in this area. The aim of this research was to study relationship between previous ankle sprains and functional-performance deficits in athletes. Materials and methods: The subjects were 40 professional athletes selected through random sampling among volunteer participants in soccer, basketball, volleyball and handball teams of Lorestan province. The subjects were divided into 2 groups: Injured group (athletes with previous ankle sprains and healthy group (athletes without previous ankle sprains. In this descriptive study we used Functional-performance tests (figure 8 hop test and side hop test to determine ankle deficits and limitations. They participated in figure 8 hop test including hopping in 8 shape course with the length of 5 meters and side hop test including 10 side hop repetitions in course with the length of 30 centimeters. Time were recorded via stopwatch. Results: After data gathering and assessing information distributions, Pearson correlation was used to assess relationships, and independent T test to assess differences between variables. Finally the results showed that there is a significant relationship between previous ankle sprains and functional-performance deficits in the athletes. Conclusion: The athletes who had previous ankle sprains indicated functional-performance deficits more than healthy athletes in completion of mentioned functional-performance tests. The functional-performance tests (figure 8 hop test and side hop test are sensitive and suitable to assess and detect functional-performance deficits in athletes. Therefore we can use the figure 8 hop and side hop tests for goals such as prevention, assessment and rehabilitation of ankle sprains without spending too much money and time.

  8. Geodetic Volcano Monitoring Research in Canary Islands: Recent Results

    Science.gov (United States)

    Fernandez, J.; Gonzalez, P. J.; Arjona, A.; Camacho, A. G.; Prieto, J. F.; Seco, A.; Tizzani, P.; Manzo, M. R.; Lanari, R.; Blanco, P.; Mallorqui, J. J.

    2009-05-01

    The Canarian Archipelago is an oceanic island volcanic chain with a long-standing history of volcanic activity (> 40 Ma). It is located off the NW coast of the African continent, lying over a transitional crust of the Atlantic African passive margin. At least 12 eruptions have been occurred on the islands of Lanzarote, Tenerife and La Palma in the last 500 years. Volcanism manifest predominantly as basaltic strombolian monogenetic activity (whole archipelago) and central felsic volcanism (active only in Tenerife Island). We concentrate our studies in the two most active islands, Tenerife and La Palma. In these islands, we tested different methodologies of geodetic monitoring systems. We use a combination of ground- and space-based techniques. At Tenerife Island, a differential interferometric study was performed to detect areas of deformation. DInSAR detected two clear areas of deformation, using this results a survey-based GPS network was designed and optimized to control those deformations and the rest of the island. Finally, using SBAS DInSAR results weak spatial long- wavelength subsidence signals has been detected. At La Palma, the first DInSAR analysis have not shown any clear deformation, so a first time series analysis was performed detecting a clear subsidence signal at Teneguia volcano, as for Tenerife a GPS network was designed and optimized taking into account stable and deforming areas. After several years of activities, geodetic results served to study ground deformations caused by a wide variety of sources, such as changes in groundwater levels, volcanic activity, volcano-tectonics, gravitational loading, etc. These results proof that a combination of ground-based and space-based techniques is suitable tool for geodetic volcano monitoring in Canary Islands. Finally, we would like to strength that those results could have serious implications on the continuous geodetic monitoring system design and implementation for the Canary Islands which is under

  9. Geodetic analysis of disputed accurate qibla direction

    Science.gov (United States)

    Saksono, Tono; Fulazzaky, Mohamad Ali; Sari, Zamah

    2018-04-01

    Muslims perform the prayers facing towards the correct qibla direction would be the only one of the practical issues in linking theoretical studies with practice. The concept of facing towards the Kaaba in Mecca during the prayers has long been the source of controversy among the muslim communities to not only in poor and developing countries but also in developed countries. The aims of this study were to analyse the geodetic azimuths of qibla calculated using three different models of the Earth. The use of ellipsoidal model of the Earth could be the best method for determining the accurate direction of Kaaba from anywhere on the Earth's surface. A muslim cannot direct himself towards the qibla correctly if he cannot see the Kaaba due to setting out process and certain motions during the prayer this can significantly shift the qibla direction from the actual position of the Kaaba. The requirement of muslim prayed facing towards the Kaaba is more as spiritual prerequisite rather than physical evidence.

  10. Data from studies of previous radioactive waste disposal in Massachusetts Bay

    International Nuclear Information System (INIS)

    Curtis, W.R.; Mardis, H.M.

    1984-12-01

    This report presents the results of studies conducted in Massachusetts Bay during 1981 and 1982. Included are data from: (1) a side scan sonar survey of disposal areas in the Bay that was carried out by the National Oceanic and Atmospheric Administration (NOAA) for EPA; (2) Collections of sediment and biota by NOAA for radiochemical analysis by EPA; (3) collections of marketplace seafood samples by the Food and Drug Administration (FDA) for radioanalysis by both FDA and EPA; and (4) a radiological monitoring survey of LLW disposal areas by EPA to determine whether there should be any concern for public health resulting from previous LLW disposals in the Bay

  11. Explicitly computing geodetic coordinates from Cartesian coordinates

    Science.gov (United States)

    Zeng, Huaien

    2013-04-01

    This paper presents a new form of quartic equation based on Lagrange's extremum law and a Groebner basis under the constraint that the geodetic height is the shortest distance between a given point and the reference ellipsoid. A very explicit and concise formulae of the quartic equation by Ferrari's line is found, which avoids the need of a good starting guess for iterative methods. A new explicit algorithm is then proposed to compute geodetic coordinates from Cartesian coordinates. The convergence region of the algorithm is investigated and the corresponding correct solution is given. Lastly, the algorithm is validated with numerical experiments.

  12. A longitudinal study of plasma insulin and glucagon in women with previous gestational diabetes

    DEFF Research Database (Denmark)

    Damm, P; Kühl, C; Hornnes, P

    1995-01-01

    OBJECTIVE: To investigate whether plasma insulin or glucagon predicts later development of diabetes in women with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: The subjects studied were 91 women with diet-treated GDM and 33 healthy women. Plasma insulin and glucagon during a 50...... at follow-up (2 had insulin-dependent diabetes mellitus, 13 had non-insulin-dependent diabetes mellitus, and 12 had impaired glucose tolerance). Compared with the control subjects, women with previous GDM had relatively impaired insulin secretion (decreased insulinogenic index and delayed peak insulin...... for subsequent development of overt diabetes (logistic regression analysis). CONCLUSIONS: Women who develop GDM have a relative insulin secretion deficiency, the severity of which is predictive for later development of diabetes. Furthermore, our data indicate that their relatively reduced beta-cell function may...

  13. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    Directory of Open Access Journals (Sweden)

    Moreno Victor

    2011-08-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. Methods CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. Results None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive, rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive, rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant, and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive. In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1

  14. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    International Nuclear Information System (INIS)

    Abulí, Anna; Morillas, Juan D; Rigau, Joaquim; Latorre, Mercedes; Fernández-Bañares, Fernando; Peña, Elena; Riestra, Sabino; Payá, Artemio; Jover, Rodrigo; Xicola, Rosa M; Llor, Xavier; Fernández-Rozadilla, Ceres; Carvajal-Carmona, Luis; Villanueva, Cristina M; Moreno, Victor; Piqué, Josep M; Carracedo, Angel; Castells, Antoni; Andreu, Montserrat; Ruiz-Ponte, Clara; Castellví-Bel, Sergi; Alonso-Espinaco, Virginia; Muñoz, Jenifer; Gonzalo, Victoria; Bessa, Xavier; González, Dolors; Clofent, Joan; Cubiella, Joaquin

    2011-01-01

    Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1 [rs698 in ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive), rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive), rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant), and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1

  15. Geodetic alignment of laser power installations

    International Nuclear Information System (INIS)

    Shtorm, V.V.; Gostev, A.M.; Drobikov, A.V.

    1989-01-01

    Main problems occuring in applied geodesy under initial alignment of laser power installation optical channel are considered. Attention is paid to alignment of lens beamguide telescopic pairs and alignment quality control. Methods and means of geodetic measurements under alignment are indicated. Conclusions are made about the degree of working through certain aspects of the problem

  16. A study about the interest and previous contact of high school students with Astronomy

    Science.gov (United States)

    Carvalho, C. L.; Zanitti, M. H. R.; Felicidade, B. L.; Gomes, A. D. T.; Dias, E. W.; Coelho, F. O.

    2016-04-01

    The currently problems in Astronomy teaching in Brazilian Basic Education contrast with the space, and the popularity that astronomical themes have in various media in the country. In this work, we present the results of a study about the interest, and previous contact of high school students from a public school in the city of "São João del-Rei"/MG with topics related to Astronomy. The study and the pedagogical intervention were carried out by students of the PIBID/CAPES/UFSJ. The intervention was performed through an oral exposition with the students' participation, followed by the use of the Stellarium program. The results suggest the majority of students surveyed are interested in Astronomy, and have had some contact with the area. However, some inconsistencies in their responses were identified and examined. The implications for research and for Astronomy Education are discussed. We also make some considerations about relationship between the lack of specific knowledge and the misinformation as one possible reason for the little interest of students in various areas of Science.

  17. Fire Risk Scoping Study: Investigation of nuclear power plant fire risk, including previously unaddressed issues

    International Nuclear Information System (INIS)

    Lambright, J.A.; Nowlen, S.P.; Nicolette, V.F.; Bohn, M.P.

    1989-01-01

    An investigation of nuclear power plant fire risk issues raised as a result of the USNRC sponsored Fire Protection Research Program at Sandia National Laboratories has been performed. The specific objectives of this study were (1) to review and requantify fire risk scenarios from four fire probabilistic risk assessments (PRAs) in light of updated data bases made available as a result of USNRC sponsored Fire Protection Research Program and updated computer fire modeling capabilities, (2) to identify potentially significant fire risk issues that have not been previously addressed in a fire risk context and to quantify the potential impact of those identified fire risk issues where possible, and (3) to review current fire regulations and plant implementation practices for relevance to the identified unaddressed fire risk issues. In performance of the fire risk scenario requantifications several important insights were gained. It was found that utilization of a more extensive operational experience base resulted in both fire occurrence frequencies and fire duration times (i.e., time required for fire suppression) increasing significantly over those assumed in the original works. Additionally, some thermal damage threshold limits assumed in the original works were identified as being nonconservative based on more recent experimental data. Finally, application of the COMPBRN III fire growth model resulted in calculation of considerably longer fire damage times than those calculated in the original works using COMPBRN I. 14 refs., 2 figs., 16 tabs

  18. Comparison of direct and geodetic mass balances on a multi-annual time scale

    Directory of Open Access Journals (Sweden)

    A. Fischer

    2011-02-01

    Full Text Available The geodetic mass balances of six Austrian glaciers over 19 periods between 1953 and 2006 are compared to the direct mass balances over the same periods. For two glaciers, Hintereisferner and Kesselwandferner, case studies showing possible reasons for discrepancies between the geodetic and the direct mass balance are presented. The mean annual geodetic mass balance for all periods is −0.5 m w.e. a−1, the mean annual direct mass balance −0.4 m w.e. a−1. The mean cumulative difference is −0.6 m w.e., the minimum −7.3 m w.e., and the maximum 5.6 m w.e. The accuracy of geodetic mass balance may depend on the accuracy of the DEMs, which ranges from 2 m w.e. for photogrammetric data to 0.02 m w.e. for airborne laser scanning (LiDAR data. Basal melt, seasonal snow cover, and density changes of the surface layer also contribute up to 0.7 m w.e. to the difference between the two methods over the investigated period of 10 yr. On Hintereisferner, the fraction of area covered by snow or firn has been changing within 1953–2006. The accumulation area is not identical with the firn area, and both are not coincident with areas of volume gain. Longer periods between the acquisition of the DEMs do not necessarily result in a higher accuracy of the geodetic mass balance. Trends in the difference between the direct and the geodetic data vary from glacier to glacier and can differ systematically for specific glaciers under specific types of climate forcing. Ultimately, geodetic and direct mass balance data are complementary, and great care must be taken when attempting to combine them.

  19. The biomechanics of running in athletes with previous hamstring injury: A case-control study.

    Science.gov (United States)

    Daly, C; Persson, U McCarthy; Twycross-Lewis, R; Woledge, R C; Morrissey, D

    2016-04-01

    Hamstring injury is prevalent with persistently high reinjury rates. We aim to inform hamstring rehabilitation by exploring the electromyographic and kinematic characteristics of running in athletes with previous hamstring injury. Nine elite male Gaelic games athletes who had returned to sport after hamstring injury and eight closely matched controls sprinted while lower limb kinematics and muscle activity of the previously injured biceps femoris, bilateral gluteus maximus, lumbar erector spinae, rectus femoris, and external oblique were recorded. Intergroup comparisons of muscle activation ratios and kinematics were performed. Previously injured athletes demonstrated significantly reduced biceps femoris muscle activation ratios with respect to ipsilateral gluteus maximus (maximum difference -12.5%, P = 0.03), ipsilateral erector spinae (maximum difference -12.5%, P = 0.01), ipsilateral external oblique (maximum difference -23%, P = 0.01), and contralateral rectus femoris (maximum difference -22%, P = 0.02) in the late swing phase. We also detected sagittal asymmetry in hip flexion (maximum 8°, P = 0.01), pelvic tilt (maximum 4°, P = 0.02), and medial rotation of the knee (maximum 6°, P = 0.03) effectively putting the hamstrings in a lengthened position just before heel strike. Previous hamstring injury is associated with altered biceps femoris associated muscle activity and potentially injurious kinematics. These deficits should be considered and addressed during rehabilitation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Geodetic precession or dragging of inertial frames?

    International Nuclear Information System (INIS)

    Ashby, N.; Shahid-Saless, B.

    1990-01-01

    In metric theories of gravity the principle of general covariance allows one to describe phenomena by means of any convenient choice of coordinate system. In this paper it is shown that in an appropriately chosen coordinate system, geodetic precession of a gyroscope orbiting a spherically symmetric, spinning mass can be recast as a Lense-Thirring frame-dragging effect without invoking spatial curvature. The origin of this reference frame moves around the source but the frame axes point in fixed directions. The drag can be interpreted to arise from the orbital angular momentum of the source around the origin of the reference frame. In this reference frame the effects of geodetic precession and Lense-Thirring drag due to intrinsic angular momentum of the source have the same origin, namely, gravitomagnetism

  1. 3D geodetic monitoring slope deformations

    Directory of Open Access Journals (Sweden)

    Weiss Gabriel

    1996-06-01

    Full Text Available For plenty of slope failures that can be found in Slovakia is necessary and very important their geodetic monitoring (because of their activity, reactivisations, checks. The paper gives new methodologies for these works, using 3D terrestrial survey technologies for measurements in convenient deformation networks. The design of an optimal type of deformation model for various kinds of landslides and their exact processing with an efficient testing procedure to determine the kinematics of the slope deformations are presented too.

  2. Rancidity inhibition study in frozen whole mackerel (scomber scombrus by a previous plant extract treatment.

    Directory of Open Access Journals (Sweden)

    Aubourg, Santiago P.

    2005-09-01

    Full Text Available The effect of flaxseeds (Linum usitatissimum on rancidity development in frozen whole mackerel (Scomber scombrus was studied. For it, fresh mackerel were dipped in flaxseeds aqueous extract during 60 min, frozen at –80 ºC during 24 hours and kept frozen (–20 ºC up to 12 months. Sampling was carried out on the initial material and at months 1, 3, 5, 7, 9 and 12 of frozen storage at –20 ºC. A parallel experiment with non treated fish was carried out in the same conditions. Rancidity development was measured by several biochemical indices (free fatty acids, peroxides, conjugated dienes and trienes, secondary oxidation products and lipoxygenase activity and complemented by the sensory analysis (skin, flesh odour, consistency and flesh appearance. As a result of the previous antioxidant treatment, peroxides showed to breakdown faster (pSe ha estudiado el efecto del lino (Linum usitatissimum en el desarrollo de rancidez en caballa entera congelada (Scomber scombrus. Para ello, caballas frescas fueron sumergidas en extractos acuosos de semillas de lino durante 60 min, congeladas a -80 ºC durante 24 h y mantenidas congeladas ( -20 ºC durante 12 meses. Se tomaron muestras del material inicial y tras 1, 3, 5, 7, 9 y 12 meses de congelación a -20 ºC . Un experimento paralelo con pescado no tratado fue llevado acabo en las mismas condiciones. El desarrollo de la rancidez fue medido por varios índices bioquímicos (ácidos grasos libres, peróxidos, dienos y trienos conjugados, productos secundarios de oxidación y actividad lipoxigenasa y completado con análisis sensorial (piel, olor de la carne, consistencia y apariencia de la carne. Como resultado del tratamiento antioxidante, los peróxidos se degradaron más rápidos (p < 0.05 después del mes 7, y por tanto, contenidos mayores (p < 0.05 de dienos y trienos conjugados pudieron ser detectados en el pescado tratado. El tratamiento antioxidante también condujo a un

  3. The impacts of source structure on geodetic parameters demonstrated by the radio source 3C371

    Science.gov (United States)

    Xu, Ming H.; Heinkelmann, Robert; Anderson, James M.; Mora-Diaz, Julian; Karbon, Maria; Schuh, Harald; Wang, Guang L.

    2017-07-01

    Closure quantities measured by very-long-baseline interferometry (VLBI) observations are independent of instrumental and propagation instabilities and antenna gain factors, but are sensitive to source structure. A new method is proposed to calculate a structure index based on the median values of closure quantities rather than the brightness distribution of a source. The results are comparable to structure indices based on imaging observations at other epochs and demonstrate the flexibility of deriving structure indices from exactly the same observations as used for geodetic analysis and without imaging analysis. A three-component model for the structure of source 3C371 is developed by model-fitting closure phases. It provides a real case of tracing how the structure effect identified by closure phases in the same observations as the delay observables affects the geodetic analysis, and investigating which geodetic parameters are corrupted to what extent by the structure effect. Using the resulting structure correction based on the three-component model of source 3C371, two solutions, with and without correcting the structure effect, are made. With corrections, the overall rms of this source is reduced by 1 ps, and the impacts of the structure effect introduced by this single source are up to 1.4 mm on station positions and up to 4.4 microarcseconds on Earth orientation parameters. This study is considered as a starting point for handling the source structure effect on geodetic VLBI from geodetic sessions themselves.

  4. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats

    Science.gov (United States)

    Gallardo-Calero, Irene; López-Fernández, Alba; Romagosa, Cleofe; Vergés, Ramona; Aguirre-Canyadell, Marius; Soldado, Francisco; Velez, Roberto

    2016-01-01

    Background: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. Methods: One hundred forty male Sprague–Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy). Clinical parameters, technical values of anastomosis, patency, and histopathological parameters were evaluated. Results: Irradiated groups (III and IV) and vein anastomosis groups (II and IV) showed significantly increased technical difficulties. Group IV showed significantly reduced patency rates (7/35) when compared with the control group (0/35). Radiotherapy significantly decreased the patency rates of the vein (7/35) when compared with the artery (1/35). Groups III and IV showed significantly reduced number of endothelial cells and also showed the presence of intimal thickening and adventitial fibrosis as compared with the control group. Conclusion: Neoadjuvant radiotherapy reduces the viability of the venous anastomosis in a preclinical rat model with a significant increase in the incidence of vein thrombosis. PMID:27975009

  5. Late preterm birth and previous cesarean section: a population-based cohort study.

    Science.gov (United States)

    Yasseen Iii, Abdool S; Bassil, Kate; Sprague, Ann; Urquia, Marcelo; Maguire, Jonathon L

    2018-02-21

    Late preterm birth (LPB) is increasingly common and associated with higher morbidity and mortality than term birth. Yet, little is known about the influence of previous cesarean section (PCS) and the occurrence of LPB in subsequent pregnancies. We aim to evaluate this association along with the potential mediation by cesarean sections in the current pregnancy. We use population-based birth registry data (2005-2012) to establish a cohort of live born singleton infants born between 34 and 41 gestational weeks to multiparous mothers. PCS was the primary exposure, LPB (34-36 weeks) was the primary outcome, and an unplanned or emergency cesarean section in the current pregnancy was the potential mediator. Associations were quantified using propensity weighted multivariable Poisson regression, and mediating associations were explored using the Baron-Kenny approach. The cohort included 481,531 births, 21,893 (4.5%) were LPB, and 119,983 (24.9%) were predated by at least one PCS. Among mothers with at least one PCS, 6307 (5.26%) were LPB. There was increased risk of LPB among women with at least one PCS (adjusted Relative Risk (aRR): 1.20 (95%CI [1.16, 1.23]). Unplanned or emergency cesarean section in the current pregnancy was identified as a strong mediator to this relationship (mediation ratio = 97%). PCS was associated with higher risk of LPB in subsequent pregnancies. This may be due to an increased risk of subsequent unplanned or emergency preterm cesarean sections. Efforts to minimize index cesarean sections may reduce the risk of LPB in subsequent pregnancies.

  6. Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.

    Science.gov (United States)

    Smith, Matthew; De Bono, Johann; Sternberg, Cora; Le Moulec, Sylvestre; Oudard, Stéphane; De Giorgi, Ugo; Krainer, Michael; Bergman, Andries; Hoelzer, Wolfgang; De Wit, Ronald; Bögemann, Martin; Saad, Fred; Cruciani, Giorgio; Thiery-Vuillemin, Antoine; Feyerabend, Susan; Miller, Kurt; Houédé, Nadine; Hussain, Syed; Lam, Elaine; Polikoff, Jonathan; Stenzl, Arnulf; Mainwaring, Paul; Ramies, David; Hessel, Colin; Weitzman, Aaron; Fizazi, Karim

    2016-09-01

    Cabozantinib is an inhibitor of kinases, including MET and vascular endothelial growth factor receptors, and has shown activity in men with previously treated metastatic castration-resistant prostate cancer (mCRPC). This blinded phase III trial compared cabozantinib with prednisone in patients with mCRPC. Men with progressive mCRPC after docetaxel and abiraterone and/or enzalutamide were randomly assigned at a two-to-one ratio to cabozantinib 60 mg once per day or prednisone 5 mg twice per day. The primary end point was overall survival (OS). Bone scan response (BSR) at week 12 as assessed by independent review committee was the secondary end point; radiographic progression-free survival (rPFS) and effects on circulating tumor cells (CTCs), bone biomarkers, serum prostate-specific antigen (PSA), and symptomatic skeletal events (SSEs) were exploratory assessments. A total of 1,028 patients were randomly assigned to cabozantinib (n = 682) or prednisone (n = 346). Median OS was 11.0 months with cabozantinib and 9.8 months with prednisone (hazard ratio, 0.90; 95% CI, 0.76 to 1.06; stratified log-rank P = .213). BSR at week 12 favored cabozantinib (42% v 3%; stratified Cochran-Mantel-Haenszel P < .001). rPFS was improved in the cabozantinib group (median, 5.6 v 2.8 months; hazard ratio, 0.48; 95% CI, 0.40 to 0.57; stratified log-rank P < .001). Cabozantinib was associated with improvements in CTC conversion, bone biomarkers, and post-random assignment incidence of SSEs but not PSA outcomes. Grade 3 to 4 adverse events and discontinuations because of adverse events were higher with cabozantinib than with prednisone (71% v 56% and 33% v 12%, respectively). Cabozantinib did not significantly improve OS compared with prednisone in heavily treated patients with mCRPC and progressive disease after docetaxel and abiraterone and/or enzalutamide. Cabozantinib had some activity in improving BSR, rPFS, SSEs, CTC conversions, and bone biomarkers but not PSA outcomes. © 2016 by

  7. First-order design of geodetic networks using the simulated annealing method

    Science.gov (United States)

    Berné, J. L.; Baselga, S.

    2004-09-01

    The general problem of the optimal design for a geodetic network subject to any extrinsic factors, namely the first-order design problem, can be dealt with as a numeric optimization problem. The classic theory of this problem and the optimization methods are revised. Then the innovative use of the simulated annealing method, which has been successfully applied in other fields, is presented for this classical geodetic problem. This method, belonging to iterative heuristic techniques in operational research, uses a thermodynamical analogy to crystalline networks to offer a solution that converges probabilistically to the global optimum. Basic formulation and some examples are studied.

  8. Ostrogradski Hamiltonian approach for geodetic brane gravity

    International Nuclear Information System (INIS)

    Cordero, Ruben; Molgado, Alberto; Rojas, Efrain

    2010-01-01

    We present an alternative Hamiltonian description of a branelike universe immersed in a flat background spacetime. This model is named geodetic brane gravity. We set up the Regge-Teitelboim model to describe our Universe where such field theory is originally thought as a second order derivative theory. We refer to an Ostrogradski Hamiltonian formalism to prepare the system to its quantization. This approach comprize the manage of both first- and second-class constraints and the counting of degrees of freedom follows accordingly.

  9. Geodetic data support trapping of ethane in Titan's polar crust

    Science.gov (United States)

    Sotin, Christophe; Rambaux, Nicolas

    2016-04-01

    Titan's surface is characterized by polar depressions that strongly influence interpretations of the gravity data. This study investigates several geodynamical models that can explain these depressions. For each model, the values of the three moments of inertia are computed numerically by discretizing the interior in spherical coordinates. The study shows that a Pratt model where the polar subsurface is made of ethane clathrates can explain the polar depression, the abrupt jump in altitude at about 60 degrees latitude, and the values of the degree 2 gravity coefficients. This model, proposed by Choukroun and Sotin [1], is based on the stability of ethane clathrate hydrates relative to methane clathrate hydrates. In addition to fitting the geodetic data, it explains the absence of ethane in Titan's atmosphere although ethane is the main product of the photolysis of methane. Other geophysical models based on latitudinal variations in the tidal heating production or in the heat flux at the base of the icy crust do not provide such a good match to the gravity and topographic observations. The ethane-clathrate model predicts that all the ethane produced by photolysis of methane at the present rate during the last billion years could be stored in the polar subsurface. It is consistent with the age of Titan's surface and that of Titan's atmospheric methane inferred from geological and geochemical observations by the Cassini/Huygens mission. The present study also emphasizes the role of mass anomalies on the interpretation of the degree 2 gravity coefficients. It shows that for Titan, a slow rotator, the values of the two equatorial moments of inertia (MoI) are largely affected by the polar depressions whereas the value of polar MoI is not. Therefore, as pointed out by previous calculations [2], calculating the moment of inertia (MoI) factor from the value of J2 could lead to major errors. This is not the case for our preferred Titan's model for which the negative polar

  10. Radon diffusion coefficients for soils. Previous studies and their application to uranium-bearing wastes

    International Nuclear Information System (INIS)

    Sasaki, Tomozo; Gunji, Yasuyoshi; Iida, Takao

    2008-01-01

    Radon diffusion in soils has been studied over the years by many researchers. The application of such studies to the evaluation of radiation exposure caused by radon from uranium-bearing wastes disposed in a shallow land site is very important. The present paper surveyed closely relevant studies and elucidated the inherent nature of radon diffusion in terms of the definition of radon diffusion coefficients. Then, basic features of measurement methods for determining radon diffusion coefficients in soils were explained. Furthermore, theoretical aspects of radon diffusion in soils were discussed in terms of microscopic radon diffusion in soils and large-scale radon diffusion through cover soil defects for uranium mill tailings. Finally, in order to apply the radon diffusion studies to uranium-bearing waste disposal in shallow land sites, new challenges were presented: elucidation of radon diffusion in uranium-bearing wastes and cover-soil cracks, and demonstration of the validity of applying only radon diffusion in the evaluation of radiation exposure caused by radon, which would come through Japanese cover soils for uranium-bearing waste disposal. (author)

  11. An attempt to evaluate horizontal crustal movement by geodetic and geological approach in the Horonobe area, Northern Hokkaido, Japan

    International Nuclear Information System (INIS)

    Tokiwa, Tetsuya; Niizato, Tadafumi; Nohara, Tsuyoshi; Asamori, Koichi; Matsuura, Yuki; Kosaka, Hideki

    2011-01-01

    In this study, we present the preliminary results for the estimation of a horizontal crustal movement by using geodetic and geological approach in the Horonobe area, northern Hokkaido, Japan. The estimations have been carried out by using a GPS data and a geological cross section obtained by applying balanced-section method. As results of this study, both of the shortening rates estimated by GPS data and balanced-section method indicate several millimeters per year. Namely, there is no contradiction between geodetic and geological data, and it is considered that Horonobe area is still situated similar tendency and magnitude of a crustal movement. It is seemingly considered that geodetic data is unhelpful for estimating the long-term crustal movement, because period of geodetic observations is a very short. However, the result of this study indicates that geodetic data provide valuable information for estimating the long-term crustal movement in the area, and it is considered that geodetic approach play an important role in improvement of the credibility of evaluation for prediction of long-term stability. (author)

  12. Interbirth interval and history of previous preeclampsia: a case–control study among multiparous women

    OpenAIRE

    Harutyunyan, Arusyak; Armenian, Haroutune; Petrosyan, Varduhi

    2013-01-01

    Abstract Background Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long in...

  13. A Review of Previous Studies on Information Processing in Career Decision Making among University Students

    OpenAIRE

    池田, 智子; Satoko, Ikeda

    2018-01-01

    This review of the researches of career choice of Japanese university students focused the studies on decision-making theory conducted in Japan. The present review suggested the necessity of examination of the effect of self-efficacy about career information search on the process of career choice. It is also needed to examine the relationship between specific self-efficacy about career information search and career decision-making self-efficacy, moreover, general self-efficacy.

  14. A Comment Upon Previous Studies on 3-D Boundary Layer Transition

    OpenAIRE

    ÇARPINLIOĞLU, Melda Özdinç

    2014-01-01

    The common feature of the experimental studies upon 3-D boundary layer development on swept flat plates cited in the available literature is the application of streamwise and/or spanwise pressure gradients. In fact; presence of the pressure gradients was suggested to be vital for having crossflow effective in 3-D boundary layer transition. In the presented paper here, this idea is questioned evaluating the results of an experimental investigation conducted on swept flat plates under the ab...

  15. Neuropsychiatric and cardiometabolic comorbidities in patients with previously diagnosed Cushing's disease: a longitudinal observational study

    OpenAIRE

    Dimopoulou, C; Geraedts, V; Stalla, G K; Sievers, C

    2015-01-01

    INTRODUCTION: Only few studies have systematically investigated neuropsychiatric aspects in patients with Cushing's disease (CD). Pain syndromes have been described in patients with pituitary adenomas, but so far no systematical investigation has been conducted in patients with CD. Additionally, CD has an association with cardiometabolic comorbidities which ultimately leads to increased morbidity and mortality. Long-term treatment of the hypercortisolic state cannot prevent the persistence of...

  16. A New Zealand based cohort study of anaesthetic trainees' career outcomes compared with previously expressed intentions.

    Science.gov (United States)

    Moran, E M L; French, R A; Kennedy, R R

    2011-09-01

    Predicting workforce requirements is a difficult but necessary part of health resource planning. A 'snapshot' workforce survey undertaken in 2002 examined issues that New Zealand anaesthesia trainees expected would influence their choice of future workplace. We have restudied the same cohort to see if that workforce survey was a good predictor of outcome. Seventy (51%) of 138 surveys were completed in 2009 compared with 100 (80%) of 138 in the 2002 survey. Eighty percent of the 2002 respondents planned consultant positions in New Zealand. We found 64% of respondents were working in New Zealand (P New Zealand based respondents but only 40% of those living outside New Zealand agreed or strongly agreed with this statement (P New Zealand but was important for only 2% of those resident in New Zealand (P New Zealand were predominantly between NZ$150,000 and $200,000 while those overseas received between NZ$300,000 and $400,000. Of those that are resident in New Zealand, 84% had studied in a New Zealand medical school compared with 52% of those currently working overseas (P < 0.01). Our study shows that stated career intentions in a group do not predict the actual group outcomes. We suggest that 'snapshot' studies examining workforce intentions are of little value for workforce planning. However we believe an ongoing program matching career aspirations against career outcomes would be a useful tool in workforce planning.

  17. Geodetic Imaging: Expanding the Boundaries of Geodesy in the 21st Century

    Science.gov (United States)

    Fernandez Diaz, J. C.; Carter, W. E.; Shrestha, R. L.; Glennie, C. L.

    2013-12-01

    High resolution (sub-meter) geodetic images covering tens to thousands of square kilometers have extended the boundaries of geodesy into related areas of the earth sciences, such as geomorphology and geodynamics, during the past decade, to archaeological exploration and site mapping during the past few years, and are now poised to transform studies of flora and fauna in the more remote regions of the world. Geodetic images produced from airborne laser scanning (ALS), a.k.a. airborne light detection and ranging (LiDAR) have proven transformative to the modern practice of geomorphology where researchers have used decimeter resolution digital elevation models (DEMs) to determine the spatial frequencies of evenly spaced features in terrain, and developed models and mathematical equations to explain how the terrain evolved to its present state and how it is expected to change in the future (Perron et al., 2009). In geodynamics researchers have used ';before' and ';after' geodetic images of the terrain near earthquakes, such as the 2010 El Mayor-Cucapah Earthquake, to quantify surface displacements and suggest models to explain the observed deformations (Oskin et. al., 2012). In archaeology, the ability of ALS to produce ';bare earth' DEMs of terrain covered with dense vegetation, including even tropical rain forests, has revolutionized the study of archaeology in highly forested areas, finding ancient structures and human modifications of landscapes not discovered by archaeologists working at sites for decades (Chase et al., 2011 & Evans et al., 2013), and finding previously unknown ruins in areas that ground exploration has not been able to penetrate since the arrival of the conquistadors in the new world in the 17th century (Carter et al., 2012). The improved spatial resolution and ability of the third generation ALS units to obtain high resolution bare earth DEMs and canopy models in areas covered in dense forests, brush, and even shallow water (steams, lakes, and

  18. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    Energy Technology Data Exchange (ETDEWEB)

    Makhlouf, Ali, E-mail: almakhsme@gmail.com; Serradj, Tayeb; Cheniti, Hamza

    2015-01-15

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10{sup 3} MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO{sub 2} eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10{sup −6} t NMVOC eq and 259.3 × 10{sup −6} t SO{sub 2} eq respectively.

  19. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    International Nuclear Information System (INIS)

    Makhlouf, Ali; Serradj, Tayeb; Cheniti, Hamza

    2015-01-01

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10 3 MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO 2 eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10 −6 t NMVOC eq and 259.3 × 10 −6 t SO 2 eq respectively

  20. Ifosfamide in previously untreated disseminated neuroblastoma. Results of Study 3A of the European Neuroblastoma Study Group.

    Science.gov (United States)

    Kellie, S J; De Kraker, J; Lilleyman, J S; Bowman, A; Pritchard, J

    1988-05-01

    A prospective study of the effectiveness of ifosfamide as a single agent in the management of previously untreated patients with Evans stage IV neuroblastoma was undertaken. Eighteen children aged more than 1 year were treated with ifosfamide (IFX) 3 g/m2 daily for 2 days immediately after diagnosis and 3 weeks later. Treatment was continued with combination chemotherapy using vincristine, cyclophosphamide, cisplatinum and etoposide (OPEC) or a variant. Mesna (2-mercaptoethane sulphonate) was given to all patients during IFX treatment to prevent urotoxicity. Eight of the 18 patients (44%) responded to IFX. Nine had greater than 66% reduction in baseline tumor volume. Of 15 evaluable patients with raised pre-treatment urinary catecholamine excretion, six (40%) achieved greater than 50% reduction in pretreatment levels. Two of 10 patients evaluable for bone marrow response had complete clearance. Toxicity was mild in all patients. Upon completing 'first line' therapy, only four patients (22%) achieved a good partial remission (GPR) or complete response (CR). Median survival was 11 months. There was a lower rate of attaining GPR and shortened median survival in patients receiving phase II IFX before OPEC or variant, compared to patients with similar pre-treatment characteristics treated with OPEC from diagnosis in an earlier study.

  1. New insights into the magma chamber activity under Mauna Loa inferred from SBAS-InSAR and geodetic inversion modelling

    Science.gov (United States)

    Varugu, B. K.; Amelung, F.

    2017-12-01

    Mauna Loa volcano, located on the Big Island, Hawaii, is the largest volcano on the earth and historically been one of the most active volcanoes on the earth. Since its last eruption in 1984, there was a decrease in the magmatic activity, yet episodic inflations with increased seismicity sparks interests in the scientific community and there is strong need to monitor the volcano with growing infrastructure close to the flanks of the volcano. Geodetic modelling of the previous inflations illustrate that the magma activity is due to inflation of hydraulically connected dike and magma chamber located from 4-8km beneath the summit (Amelung et al. 2007). Most of the seismicity observed on Mauna Loa is due to the movement along a decollement fault situated at the base of the volcano. Magma inflation under Mauna Loa has started again during the last quarter of 2013 and is continuing still with an increased seismicity. In this study, we used 140 images form COSMO SkyMED between 2013-2017 to derive and model the ground deformation. We carried out time series InSAR analysis using Small Baseline (SB) approach. While the deformation pattern seems similar in many ways to the previous inflation periods, geodetic modelling for inversion of source parameters indicate a significant propagation of the dike ( 1 km) into the South West Rift Zone(SWRZ) and a decreased depth of the dike top from summit, compared to the previous inflations. Such propagation needs to be studied further in view of the steep slope of SWRZ. In understanding the dynamics of this propagating dike, we also observed an increased seismic activity since 2014 in the vicinity of the modelled dike. Here in this study we attempt to characterize the stresses induced by the propagating dike and seaward slipping movement along the basal decollement, to explain the increased seismicity using a finite element model.

  2. DETECTION OF COASTLINE DEFORMATION USING REMOTE SENSING AND GEODETIC SURVEYS

    Directory of Open Access Journals (Sweden)

    A. Sabuncu

    2016-06-01

    Full Text Available The coastal areas are being destroyed due to the usage that effect the natural balance. Unconsciously sand mining from the sea for nearshore nourishment and construction uses are the main ones. Physical interferences for mining of sand cause an ecologic threat to the coastal environment. However, use of marine sand is inevitable because of economic reasons or unobtainable land-based sand resources. The most convenient solution in such a protection–usage dilemma is to reduce negative impacts of sand production from marine. This depends on the accurate determination of criteriaon production place, style, and amount of sand. With this motivation, nearshore geodedic surveying studies performed on Kilyos Campus of Bogazici University located on the Black Sea coast, north of Istanbul, Turkey between 2001-2002. The study area extends 1 km in the longshore. Geodetic survey was carried out in the summer of 2001 to detect the initial condition for the shoreline. Long-term seasonal changes in shoreline positions were determined biannually. The coast was measured with post-processed kinematic GPS. Besides, shoreline change has studied using Landsat imagery between the years 1986-2015. The data set of Landsat 5 imageries were dated 05.08.1986 and 31.08.2007 and Landsat 7 imageries were dated 21.07.2001 and 28.07.2015. Landcover types in the study area were analyzed on the basis of pixel based classification method. Firstly, unsupervised classification based on ISODATA (Iterative Self Organizing Data Analysis Technique has been applied and spectral clusters have been determined that gives prior knowledge about the study area. In the second step, supervised classification was carried out by using the three different approaches which are minimum-distance, parallelepiped and maximum-likelihood. All pixel based classification processes were performed with ENVI 4.8 image processing software. Results of geodetic studies and classification outputs will be

  3. Plate motions and deformations from geologic and geodetic data

    Science.gov (United States)

    Jordan, T. H.

    1986-06-01

    Research effort on behalf of the Crustal Dynamics Project focused on the development of methodologies suitable for the analysis of space-geodetic data sets for the estimation of crustal motions, in conjunction with results derived from land-based geodetic data, neo-tectonic studies, and other geophysical data. These methodologies were used to provide estimates of both global plate motions and intraplate deformation in the western U.S. Results from the satellite ranging experiment for the rate of change of the baseline length between San Diego and Quincy, California indicated that relative motion between the North American and Pacific plates over the course of the observing period during 1972 to 1982 were consistent with estimates calculated from geologic data averaged over the past few million years. This result, when combined with other kinematic constraints on western U.S. deformation derived from land-based geodesy, neo-tectonic studies, and other geophysical data, places limits on the possible extension of the Basin and Range province, and implies significant deformation is occurring west of the San Andreas fault. A new methodology was developed to analyze vector-position space-geodetic data to provide estimates of relative vector motions of the observing sites. The algorithm is suitable for the reduction of large, inhomogeneous data sets, and takes into account the full position covariances, errors due to poorly resolved Earth orientation parameters and vertical positions, and reduces baises due to inhomogeneous sampling of the data. This methodology was applied to the problem of estimating the rate-scaling parameter of a global plate tectonic model using satellite laser ranging observations over a five-year interval. The results indicate that the mean rate of global plate motions for that interval are consistent with those averaged over several million years, and are not consistent with quiescent or greatly accelerated plate motions. This methodology was also

  4. Resolution testing and limitations of geodetic and tsunami datasets for finite fault inversions along subduction zones

    Science.gov (United States)

    Williamson, A.; Newman, A. V.

    2017-12-01

    Finite fault inversions utilizing multiple datasets have become commonplace for large earthquakes pending data availability. The mixture of geodetic datasets such as Global Navigational Satellite Systems (GNSS) and InSAR, seismic waveforms, and when applicable, tsunami waveforms from Deep-Ocean Assessment and Reporting of Tsunami (DART) gauges, provide slightly different observations that when incorporated together lead to a more robust model of fault slip distribution. The merging of different datasets is of particular importance along subduction zones where direct observations of seafloor deformation over the rupture area are extremely limited. Instead, instrumentation measures related ground motion from tens to hundreds of kilometers away. The distance from the event and dataset type can lead to a variable degree of resolution, affecting the ability to accurately model the spatial distribution of slip. This study analyzes the spatial resolution attained individually from geodetic and tsunami datasets as well as in a combined dataset. We constrain the importance of distance between estimated parameters and observed data and how that varies between land-based and open ocean datasets. Analysis focuses on accurately scaled subduction zone synthetic models as well as analysis of the relationship between slip and data in recent large subduction zone earthquakes. This study shows that seafloor deformation sensitive datasets, like open-ocean tsunami waveforms or seafloor geodetic instrumentation, can provide unique offshore resolution for understanding most large and particularly tsunamigenic megathrust earthquake activity. In most environments, we simply lack the capability to resolve static displacements using land-based geodetic observations.

  5. Multi-geodetic characterization of the seasonal signal at the CERGA geodetic reference, France

    Science.gov (United States)

    Memin, A.; Viswanathan, V.; Fienga, A.; Santamaría-Gómez, A.; Boy, J. P.

    2016-12-01

    Crustal deformations due to surface-mass loading account for a significant part of the variability in geodetic time series. A perfect understanding of the loading signal observed by geodetic techniques should help in improving terrestrial reference frame (TRF) realizations. Yet, discrepancies between crustal motion estimates from models of surface-mass loading and observations are still too large so that no model is currently recommended by the IERS for reducing the data. We investigate the discrepancy observed in the seasonal variations of the CERGA station, South of France.We characterize the seasonal motions of the reference geodetic station CERGA from GNSS, SLR and LLR. We compare the station motion observed with GNSS and SLR and we estimate changes in the station-to-the-moon distance using an improved processing strategy. We investigate the consistency between these geodetic techniques and compare the observed station motion with that estimated using models of surface-mass change. In that regard, we compute atmospheric loading effects using surface pressure fields from ECMWF, assuming an ocean response according to the classical inverted barometer (IB) assumption, considered to be valid for periods typically exceeding a week. We also used general circulation ocean models (ECCO and GLORYS) forced by wind, heat and fresh water fluxes. The continental water storage is described using GLDAS/Noah and MERRA-land models.Using the surface-mass models, we estimate the amplitude of the seasonal vertical motion of the CERGA station ranging between 5 and 10 mm with a maximum reached in August, mostly due to hydrology. The horizontal seasonal motion of the station may reach up to 3 mm. Such a station motion should induce a change in the distance to the moon reaching up to 10 mm, large enough to be detected in LLR time series and compared to GNSS- and SLR-derived motion.

  6. Introducing a New Software for Geodetic Analysis

    Science.gov (United States)

    Hjelle, Geir Arne; Dähnn, Michael; Fausk, Ingrid; Kirkvik, Ann-Silje; Mysen, Eirik

    2017-04-01

    At the Norwegian Mapping Authority, we are currently developing Where, a new software for geodetic analysis. Where is built on our experiences with the Geosat software, and will be able to analyse and combine data from VLBI, SLR, GNSS and DORIS. The software is mainly written in Python which has proved very fruitful. The code is quick to write and the architecture is easily extendable and maintainable, while at the same time taking advantage of well-tested code like the SOFA and IERS libraries. This presentation will show some of the current capabilities of Where, including benchmarks against other software packages, and outline our plans for further progress. In addition we will report on some investigations we have done experimenting with alternative weighting strategies for VLBI.

  7. Encouraging Deep Approach to Learning in Civil and Geodetic Engineering

    Directory of Open Access Journals (Sweden)

    Gašper Mrak

    2016-10-01

    Full Text Available This paper presents activities and changes applied to the teaching process within selected courses offered by Faculty of civil and geodetic engineering, University of Ljubljana, Slovenia. Theoretical background, evaluated from the point of the technical education needs, is presented. It can be seen that special focus has to be made to the students' motivation for deep learning which guarantees optimal balance between acquisition of concepts and skills, information processing and integration of fragmented pieces of knowledge into complex structures. Three case studies used to test theoretical points of departure are presented. Results of the introduced novelties and changes have been evaluated through the assessment of knowledge, students' satisfaction and teaching staff evaluations. For conclusive results, monitoring over a longer period of time should be conducted.

  8. Misbheaving Faults: The Expanding Role of Geodetic Imaging in Unraveling Unexpected Fault Slip Behavior

    Science.gov (United States)

    Barnhart, W. D.; Briggs, R.

    2015-12-01

    Geodetic imaging techniques enable researchers to "see" details of fault rupture that cannot be captured by complementary tools such as seismology and field studies, thus providing increasingly detailed information about surface strain, slip kinematics, and how an earthquake may be transcribed into the geological record. For example, the recent Haiti, Sierra El Mayor, and Nepal earthquakes illustrate the fundamental role of geodetic observations in recording blind ruptures where purely geological and seismological studies provided incomplete views of rupture kinematics. Traditional earthquake hazard analyses typically rely on sparse paleoseismic observations and incomplete mapping, simple assumptions of slip kinematics from Andersonian faulting, and earthquake analogs to characterize the probabilities of forthcoming ruptures and the severity of ground accelerations. Spatially dense geodetic observations in turn help to identify where these prevailing assumptions regarding fault behavior break down and highlight new and unexpected kinematic slip behavior. Here, we focus on three key contributions of space geodetic observations to the analysis of co-seismic deformation: identifying near-surface co-seismic slip where no easily recognized fault rupture exists; discerning non-Andersonian faulting styles; and quantifying distributed, off-fault deformation. The 2013 Balochistan strike slip earthquake in Pakistan illuminates how space geodesy precisely images non-Andersonian behavior and off-fault deformation. Through analysis of high-resolution optical imagery and DEMs, evidence emerges that a single fault map slip as both a strike slip and dip slip fault across multiple seismic cycles. These observations likewise enable us to quantify on-fault deformation, which account for ~72% of the displacements in this earthquake. Nonetheless, the spatial distribution of on- and off-fault deformation in this event is highly spatially variable- a complicating factor for comparisons

  9. Estimating the effect of current, previous and never use of drugs in studies based on prescription registries

    DEFF Research Database (Denmark)

    Nielsen, Lars Hougaard; Løkkegaard, Ellen; Andreasen, Anne Helms

    2009-01-01

    of this misclassification for analysing the risk of breast cancer. MATERIALS AND METHODS: Prescription data were obtained from Danish Registry of Medicinal Products Statistics and we applied various methods to approximate treatment episodes. We analysed the duration of HT episodes to study the ability to identify......PURPOSE: Many studies which investigate the effect of drugs categorize the exposure variable into never, current, and previous use of the study drug. When prescription registries are used to make this categorization, the exposure variable possibly gets misclassified since the registries do...... not carry any information on the time of discontinuation of treatment.In this study, we investigated the amount of misclassification of exposure (never, current, previous use) to hormone therapy (HT) when the exposure variable was based on prescription data. Furthermore, we evaluated the significance...

  10. Propagation of uncertainty by Monte Carlo simulations in case of basic geodetic computations

    Directory of Open Access Journals (Sweden)

    Wyszkowska Patrycja

    2017-12-01

    Full Text Available The determination of the accuracy of functions of measured or adjusted values may be a problem in geodetic computations. The general law of covariance propagation or in case of the uncorrelated observations the propagation of variance (or the Gaussian formula are commonly used for that purpose. That approach is theoretically justified for the linear functions. In case of the non-linear functions, the first-order Taylor series expansion is usually used but that solution is affected by the expansion error. The aim of the study is to determine the applicability of the general variance propagation law in case of the non-linear functions used in basic geodetic computations. The paper presents errors which are a result of negligence of the higher-order expressions and it determines the range of such simplification. The basis of that analysis is the comparison of the results obtained by the law of propagation of variance and the probabilistic approach, namely Monte Carlo simulations. Both methods are used to determine the accuracy of the following geodetic computations: the Cartesian coordinates of unknown point in the three-point resection problem, azimuths and distances of the Cartesian coordinates, height differences in the trigonometric and the geometric levelling. These simulations and the analysis of the results confirm the possibility of applying the general law of variance propagation in basic geodetic computations even if the functions are non-linear. The only condition is the accuracy of observations, which cannot be too low. Generally, this is not a problem with using present geodetic instruments.

  11. Propagation of uncertainty by Monte Carlo simulations in case of basic geodetic computations

    Science.gov (United States)

    Wyszkowska, Patrycja

    2017-12-01

    The determination of the accuracy of functions of measured or adjusted values may be a problem in geodetic computations. The general law of covariance propagation or in case of the uncorrelated observations the propagation of variance (or the Gaussian formula) are commonly used for that purpose. That approach is theoretically justified for the linear functions. In case of the non-linear functions, the first-order Taylor series expansion is usually used but that solution is affected by the expansion error. The aim of the study is to determine the applicability of the general variance propagation law in case of the non-linear functions used in basic geodetic computations. The paper presents errors which are a result of negligence of the higher-order expressions and it determines the range of such simplification. The basis of that analysis is the comparison of the results obtained by the law of propagation of variance and the probabilistic approach, namely Monte Carlo simulations. Both methods are used to determine the accuracy of the following geodetic computations: the Cartesian coordinates of unknown point in the three-point resection problem, azimuths and distances of the Cartesian coordinates, height differences in the trigonometric and the geometric levelling. These simulations and the analysis of the results confirm the possibility of applying the general law of variance propagation in basic geodetic computations even if the functions are non-linear. The only condition is the accuracy of observations, which cannot be too low. Generally, this is not a problem with using present geodetic instruments.

  12. An fMRI study of neuronal activation in schizophrenia patients with and without previous cannabis use

    Directory of Open Access Journals (Sweden)

    Else-Marie eLøberg

    2012-10-01

    Full Text Available Previous studies have mostly shown positive effects of cannabis use on cognition in patients with schizophrenia, which could reflect lower neurocognitive vulnerability. There are however no studies comparing whether such cognitive differences have neuronal correlates. Thus, the aim of the present study was to compare whether patients with previous cannabis use differ in brain activation from patients who has never used cannabis. The patients groups were compared on the ability to up-regulate an effort mode network during a cognitive task and down-regulate activation in the same network during a task-absent condition. Task-present and task-absent brain activation was measured by functional magnetic resonance neuroimaging (fMRI. Twenty-six patients with a DSM-IV and ICD-10 diagnosis of schizophrenia were grouped into a previous cannabis user group and a no-cannabis group. An auditory dichotic listening task with instructions of attention focus on either the right or left ear stimulus was used to tap verbal processing, attention and cognitive control, calculated as an aggregate score. When comparing the two groups, there were remaining activations in the task-present condition for the cannabis group, not seen in the no-cannabis group, while there was remaining activation in the task-absent condition for the no-cannabis group, not seen in the cannabis group. Thus, the patients with previous cannabis use showed increased activation in an effort mode network and decreased activation in the default mode network as compared to the no-cannabis group. It is concluded that the present study show some differences in brain activation to a cognitively challenging task between previous cannabis and no-cannabis schizophrenia patients.

  13. Geodetic Control Points - Multi-State Control Point Database

    Data.gov (United States)

    NSGIC State | GIS Inventory — The Multi-State Control Point Database (MCPD) is a database of geodetic and mapping control covering Idaho and Montana. The control were submitted by registered land...

  14. Integration of space geodesy: a US National Geodetic Observatory

    Science.gov (United States)

    Yunck, Thomas P.; Neilan, Ruth

    2003-01-01

    In the interest of improving the performance and efficiency of space geodesy a diverse group in the U.S., in collaboration with IGGOS, has begun to establish a unified National Geodetic Observatory (NGO).

  15. Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema : Subgroup analysis of the MEAD study

    OpenAIRE

    Augustin, A.J.; Kuppermann, B.D.; Lanzetta, P.; Loewenstein, A.; Li, X.; Cui, H.; Hashad, Y.; Whitcup, S.M.; Abujamra, S.; Acton, J.; Ali, F.; Antoszyk, A.; Awh, C.C.; Barak, A.; Bartz-Schmidt, K.U.

    2015-01-01

    Background Dexamethasone intravitreal implant 0.7?mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results to evaluate the efficacy and safety of DEX 0.7 treatment in patients with previously treated DME. Methods Three-year, randomized, sham-controlled phase 3 study in patients with DME, best-corrected visual acuity (BCVA) of 34?68 Early Treatment...

  16. Youth suicide: an insight into previous hospitalisation for injury and sociodemographic conditions from a nationwide cohort study.

    Science.gov (United States)

    Zambon, Francesco; Laflamme, Lucie; Spolaore, Paolo; Visentin, Cristiana; Hasselberg, Marie

    2011-06-01

    This study investigates the degree to which a previous hospitalisation for injury of any intent is a risk of subsequent youth suicide and whether this association is influenced by family socioeconomic status or economic stress. A nationwide register-based cohort study was conducted covering all Swedish subjects born between January 1977 and December 1991 (N=1,616,342, male/female ratio=1.05). The cohort subjects were followed-up from January 1998 to December 2003, when aged 7-26 years. Poisson regression and the likelihood ratio test (95% CI) were used to assess the age-adjusted effect of hospitalisation for injuries of various intent on youth suicide and its effect once adjusted for family sociodemographic and social circumstances. Each set of exposures was associated independently and significantly with suicide mortality. Being hospitalised for self-inflicted injuries or injuries of undetermined intent was associated with a risk of suicide 36 to 47 times, respectively, that of subjects never hospitalised in the period under study (95% CI 28.36 to 45.58 and 26.67 to 83.87 for self-inflicted injuries and for events of undetermined intent, respectively; overall psuicide (RR 3.08; 95% CI 2.26 to 4.19). These effects were solid and not substantially altered after adjustment for family demographic and socioeconomic circumstances. A strong association exists between previous hospitalisation for injury of any intent and youth suicide. The association is robust and unaltered by family socioeconomic circumstances.

  17. Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women

    Science.gov (United States)

    Gehlbach, Stephen; Saag, Kenneth G.; Adachi, Jonathan D.; Hooven, Fred H.; Flahive, Julie; Boonen, Steven; Chapurlat, Roland D.; Compston, Juliet E.; Cooper, Cyrus; Díez-Perez, Adolfo; Greenspan, Susan L.; LaCroix, Andrea Z.; Netelenbos, J. Coen; Pfeilschifter, Johannes; Rossini, Maurizio; Roux, Christian; Sambrook, Philip N.; Silverman, Stuart; Siris, Ethel S.; Watts, Nelson B.; Lindsay, Robert

    2016-01-01

    Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women ≥ 55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or ≥3 fractures since age 45. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no prior fractures, women with 1, 2, or ≥ 3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with ≥3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio 7.3) and hip (hazard ratio 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture; women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. PMID:22113888

  18. Previous experiences and emotional baggage as barriers to lifestyle change - a qualitative study of Norwegian Healthy Life Centre participants.

    Science.gov (United States)

    Følling, Ingrid S; Solbjør, Marit; Helvik, Anne-S

    2015-06-23

    Changing lifestyle is challenging and difficult. The Norwegian Directorate of Health recommends that all municipalities establish Healthy Life Centres targeted to people with lifestyle issues. Little is known about the background, experiences and reflections of participants. More information is needed about participants to shape effective lifestyle interventions with lasting effect. This study explores how participants in a lifestyle intervention programme describe previous life experiences in relation to changing lifestyle. Semi-structured qualitative in-depth interviews were performed with 23 participants (16 women and 7 men) aged 18 - 70 years. The data were analysed using systematic text condensation searching for issues describing participants' responses, and looking for the essence, aiming to share the basis of life-world experiences as valid knowledge. Participants identified two main themes: being stuck in old habits, and being burdened with emotional baggage from their previous negative experiences. Participants expressed a wish to change their lifestyles, but were unable to act in accordance with the health knowledge they possessed. Previous experiences with lifestyle change kept them from initiating attempts without professional assistance. Participants also described being burdened by an emotional baggage with problems from childhood and/or with family, work and social life issues. Respondents said that they felt that emotional baggage was an important explanation for why they were stuck in old habits and that conversely, being stuck in old habits added load to their already emotional baggage and made it heavier. Behavioural change can be hard to perform as psychological distress from life baggage can influence the ability to change. The study participants' experience of being stuck in old habits and having substantial emotional baggage raises questions as to whether or not Healthy Life Centres are able to help participants who need to make a lifestyle

  19. Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

    Science.gov (United States)

    Ohtsu, Atsushi; Ajani, Jaffer A.; Bai, Yu-Xian; Bang, Yung-Jue; Chung, Hyun-Cheol; Pan, Hong-Ming; Sahmoud, Tarek; Shen, Lin; Yeh, Kun-Huei; Chin, Keisho; Muro, Kei; Kim, Yeul Hong; Ferry, David; Tebbutt, Niall C.; Al-Batran, Salah-Eddin; Smith, Heind; Costantini, Chiara; Rizvi, Syed; Lebwohl, David; Van Cutsem, Eric

    2013-01-01

    Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months with everolimus and 4.3 months with placebo (hazard ratio, 0.90; 95% CI, 0.75 to 1.08; P = .124). Median PFS was 1.7 months and 1.4 months in the everolimus and placebo arms, respectively (hazard ratio, 0.66; 95% CI, 0.56 to 0.78). Common grade 3/4 adverse events included anemia, decreased appetite, and fatigue. The safety profile was similar in patients enrolled in Asia versus ROW. Conclusion Compared with BSC, everolimus did not significantly improve overall survival for advanced gastric cancer that progressed after one or two lines of previous systemic chemotherapy. The safety profile observed for everolimus was consistent with that observed for everolimus in other cancers. PMID:24043745

  20. Doxorubicin and ifosfamide combination chemotherapy in previously treated acute leukemia in adults: a Southwest Oncology Group pilot study.

    Science.gov (United States)

    Ryan, D H; Bickers, J N; Vial, R H; Hussein, K; Bottomley, R; Hewlett, J S; Wilson, H E; Stuckey, W J

    1980-01-01

    The Southwest Oncology Group did a limited institutional pilot study of the combination of doxorubicin and ifosfamide in the treatment of previously treated adult patients with acute leukemia. Thirty-four patients received one or two courses of the combination. All patients had received prior chemotherapy and 32 had received prior anthracycline chemotherapy. Three patients died before their responses could be fully evaluated. Fourteen patients achieved complete remission (41%) and one patient achieved partial remission. The complete remission rate was 27% for patients with acute myeloblastic leukemia (myelomonoblastic leukemia, monoblastic leukemia, and erythroleukemia) and 89% for patients with acute lymphocytic and undifferentiated leukemia (ALL). Toxic effects included severe hematologic reactions in 33 of 34 patients, hematuria in six patients, altered sensorium in one patient, and congestive heart failure in one patient. The safety of the combination was established and toxic side effects of this therapy were tolerable. The 89% complete remission rate for previously treated patients with ALL suggests that the combination of doxorubicin and ifosfamide may be particularly effective in ALL.

  1. Stress coupling in the seismic cycle indicated from geodetic measurements

    Science.gov (United States)

    Wang, L.; Hainzl, S.; Zoeller, G.; Holschneider, M.

    2012-12-01

    The seismic cycle includes several phases, the interseismic, coseismic and postseismic phase. In the interseismic phase, strain gradually builds up around the overall locked fault in tens to thousands of years, while it is coseismically released in seconds. In the postseismic interval, stress relaxation lasts months to years, indicated by evident aseismic deformations which have been indicated to release comparable or even higher strain energy than the main shocks themselves. Benefiting from the development of geodetic observatory, e.g., Global Positioning System (GPS) and Interferometric Synthetic Aperture Radar (InSAR) in the last two decades, the measurements of surface deformation have been significantly improved and become valuable information for understanding the stress evolution on the large fault plane. In this study, we utilize the GPS/InSAR data to investigate the slip deficit during the interseismic phase, the coseismic slip and the early postseismic creep on the fault plane. However, it is already well-known that slip inversions based only on the surface measurements are typically non-unique and subject to large uncertainties. To reduce the ambiguity, we utilize the assumption of stress coupling between interseismic and coseismic phases, and between coseismic and postseismic phases. We use a stress constrained joint inversion in Bayesian approach (Wang et al., 2012) to invert simultaneously for (1) interseismic slip deficit and coseismic slip, and (2) coseismic slip and postseismic creep. As case studies, we analyze earthquakes occurred in well-instrumented regions such as the 2004 M6.0 Parkfield earthquake, the 2010 M8.7 earthquake and the 2011 M9.1 Tohoku-Oki earthquake. We show that the inversion with the stress-coupling constraint leads to better constrained slip distributions. Meanwhile, the results also indicate that the assumed stress coupling is reasonable and can be well reflected from the available geodetic measurements. Reference: Lifeng

  2. The Australian Geodetic Observing Program. Current Status and Future Plans

    Science.gov (United States)

    Johnston, G.; Dawson, J. H.

    2015-12-01

    Over the last decade, the Australian government has through programs like AuScope, the Asia Pacific Reference Frame (APREF), and the Pacific Sea Level Monitoring (PSLM) Project made a significant contribution to the Global Geodetic Observing Program. In addition to supporting the national research priorities, this contribution is justified by Australia's growing economic dependence on precise positioning to underpin efficient transportation, geospatial data management, and industrial automation (e.g., robotic mining and precision agriculture) and the consequent need for the government to guarantee provision of precise positioning products to the Australian community. It is also well recognised within Australia that there is an opportunity to exploit our near unique position as being one of the few regions in the world to see all new and emerging satellite navigation systems including Galileo (Europe), GPS III (USA), GLONASS (Russia), Beidou (China), QZSS (Japan) and IRNSS (India). It is in this context that the Australian geodetic program will build on earlier efforts and further develop its key geodetic capabilities. This will include the creation of an independent GNSS analysis capability that will enable Australia to contribute to the International GNSS Service (IGS) and an upgrade of key geodetic infrastructure including the national VLBI and GNSS arrays. This presentation will overview the significant geodetic activities undertaken by the Australian government and highlight its future plans.

  3. Demonstration of the Cascadia G‐FAST geodetic earthquake early warning system for the Nisqually, Washington, earthquake

    Science.gov (United States)

    Crowell, Brendan; Schmidt, David; Bodin, Paul; Vidale, John; Gomberg, Joan S.; Hartog, Renate; Kress, Victor; Melbourne, Tim; Santillian, Marcelo; Minson, Sarah E.; Jamison, Dylan

    2016-01-01

    A prototype earthquake early warning (EEW) system is currently in development in the Pacific Northwest. We have taken a two‐stage approach to EEW: (1) detection and initial characterization using strong‐motion data with the Earthquake Alarm Systems (ElarmS) seismic early warning package and (2) the triggering of geodetic modeling modules using Global Navigation Satellite Systems data that help provide robust estimates of large‐magnitude earthquakes. In this article we demonstrate the performance of the latter, the Geodetic First Approximation of Size and Time (G‐FAST) geodetic early warning system, using simulated displacements for the 2001Mw 6.8 Nisqually earthquake. We test the timing and performance of the two G‐FAST source characterization modules, peak ground displacement scaling, and Centroid Moment Tensor‐driven finite‐fault‐slip modeling under ideal, latent, noisy, and incomplete data conditions. We show good agreement between source parameters computed by G‐FAST with previously published and postprocessed seismic and geodetic results for all test cases and modeling modules, and we discuss the challenges with integration into the U.S. Geological Survey’s ShakeAlert EEW system.

  4. The Impact of Sea Level Rise on Geodetic Vertical Datum of Peninsular Malaysia

    Science.gov (United States)

    Din, A. H. M.; Abazu, I. C.; Pa'suya, M. F.; Omar, K. M.; Hamid, A. I. A.

    2016-09-01

    Sea level rise is rapidly turning into major issues among our community and all levels of the government are working to develop responses to ensure these matters are given the uttermost attention in all facets of planning. It is more interesting to understand and investigate the present day sea level variation due its potential impact, particularly on our national geodetic vertical datum. To determine present day sea level variation, it is vital to consider both in-situ tide gauge and remote sensing measurements. This study presents an effort to quantify the sea level rise rate and magnitude over Peninsular Malaysia using tide gauge and multi-mission satellite altimeter. The time periods taken for both techniques are 32 years (from 1984 to 2015) for tidal data and 23 years (from 1993 to 2015) for altimetry data. Subsequently, the impact of sea level rise on Peninsular Malaysia Geodetic Vertical Datum (PMGVD) is evaluated in this study. the difference between MSL computed from 10 years (1984 - 1993) and 32 years (1984 - 2015) tidal data at Port Kelang showed that the increment of sea level is about 27mm. The computed magnitude showed an estimate of the long-term effect a change in MSL has on the geodetic vertical datum of Port Kelang tide gauge station. This will help give a new insight on the establishment of national geodetic vertical datum based on mean sea level data. Besides, this information can be used for a wide variety of climatic applications to study environmental issues related to flood and global warming in Malaysia.

  5. THE IMPACT OF SEA LEVEL RISE ON GEODETIC VERTICAL DATUM OF PENINSULAR MALAYSIA

    Directory of Open Access Journals (Sweden)

    A. H. M. Din

    2016-09-01

    Full Text Available Sea level rise is rapidly turning into major issues among our community and all levels of the government are working to develop responses to ensure these matters are given the uttermost attention in all facets of planning. It is more interesting to understand and investigate the present day sea level variation due its potential impact, particularly on our national geodetic vertical datum. To determine present day sea level variation, it is vital to consider both in-situ tide gauge and remote sensing measurements. This study presents an effort to quantify the sea level rise rate and magnitude over Peninsular Malaysia using tide gauge and multi-mission satellite altimeter. The time periods taken for both techniques are 32 years (from 1984 to 2015 for tidal data and 23 years (from 1993 to 2015 for altimetry data. Subsequently, the impact of sea level rise on Peninsular Malaysia Geodetic Vertical Datum (PMGVD is evaluated in this study. the difference between MSL computed from 10 years (1984 – 1993 and 32 years (1984 – 2015 tidal data at Port Kelang showed that the increment of sea level is about 27mm. The computed magnitude showed an estimate of the long-term effect a change in MSL has on the geodetic vertical datum of Port Kelang tide gauge station. This will help give a new insight on the establishment of national geodetic vertical datum based on mean sea level data. Besides, this information can be used for a wide variety of climatic applications to study environmental issues related to flood and global warming in Malaysia.

  6. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    International Nuclear Information System (INIS)

    Padilla, R.; Espen, P. van; Torres, P.P. Godo

    2006-01-01

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a 241 Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery

  7. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, R. [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), Laboratorio de Analisis Quimico, Calle 30 no. 502, Playa, Ciudad Habana (Cuba)]. E-mail: roman.padilla@infomed.sld.cu; Espen, P. van [University of Antwerp (Belgium); Torres, P.P. Godo [Centro de Antropologia, Havana (Cuba)

    2006-02-03

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a {sup 241}Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery.

  8. Treatment satisfaction with paliperidone extended-release tablets: open-label study in schizophrenia patients dissatisfied with previous antipsychotic medication

    Directory of Open Access Journals (Sweden)

    Yang FD

    2017-04-01

    Full Text Available Fu De Yang,1 Juan Li,1 Yun Long Tan,1 Wei Ye Liang,1 Rongzhen Zhang,1 Ning Wang,1 Wei Feng,1 Shangli Cai,2 Jian Min Zhuo,2 Li Li Zhang2 1Beijing Hui-Long-Guan Hospital, 2Department of Medical Affairs, Xian Janssen Pharmaceutical Ltd, Beijing, People’s Republic of China Objective: The aim of this study was to evaluate the changes in treatment satisfaction after switching to paliperidone extended-release (ER in Chinese schizophrenia patients dissatisfied with their previous antipsychotic treatment.Methods: In this 8-week, open-label, single-arm, multicenter, prospective study, 1,693 patients dissatisfied with previous antipsychotic medication were enrolled and switched to paliperidone ER tablets (3–12 mg/d based on clinical judgment. The primary efficacy end point was change in Medication Satisfaction Questionnaire (MSQ score from baseline to week 8. The secondary end points included percentage of patients with MSQ score ≥4, as well as changes in Clinical Global Improvement-Severity (CGI-S and Personal and Social Performance (PSP scores.Results: MSQ scores increased significantly from baseline (mean [standard deviation {SD}]: 2.48 [0.55] to week 8 (5.47 [0.89], P<0.0001; primary end point, full analysis set. The percentage of patients with MSQ score ≥4 was 95.9% at week 8, indicating that most of the patients were satisfied with their treatment. Significant (P<0.0001 improvements from baseline to week 8 were noted in CGI-S score (2.37 [1.20] and PSP score (25.5 [15.0]. A total of 174 (10.28% patients experienced adverse events (AEs. The most common (>10 patients events were extrapyramidal disorder (n=84, 4.96%, poor quality sleep (n=18, 1.06% and akathisia (n=13, 0.77%. The majority of AEs were mild to moderate in severity. No deaths occurred.Conclusion: Treatment satisfaction improved after switching to paliperidone ER from the previous antipsychotic in Chinese patients with schizophrenia. Keywords: atypical antipsychotics, open label

  9. Value and reliability of findings from previous epidemiologic studies in the assessment of radiation-related cancer risks. Pt. 3

    International Nuclear Information System (INIS)

    Frasch, G.; Martignoni, K.

    1990-01-01

    The theories put forward here are predominantly based on pooled data from previous studies in a number of cohorts made up by mostly non-average individuals. These studies were carried out by various researchers and differed in procedures and aims. Factors of major importance to the validity and reliability of the conclusions drawn from this study are pointed out. In one chapter some light is thrown on factors known to bear a relation to the incidence of radiation-induced cancer of the breast, even though at present this can only very vaguely be described on a quantitative basis. These factors include fractionated dose regimens, pregnancies and parturitions, menarche, menopause, synergisms as well as secondary cancer of the breast. The available body of evidence suggests that exposure of each of 1 million women to a dose of 10 mGy (rad) can be linked with approx. 3 additional cases of mammary cancer reported on an average per year after the latency period. The fact that there is some statistical scatter around this value is chiefly attributable to age-related causes at the beginning of exposure. Differences in ethnic and cultural characteristics between the populations investigated appeared to be less important here. (orig./MG) [de

  10. Barriers to postpartum screening for type 2 diabetes: a qualitative study of women with previous gestational diabetes.

    Science.gov (United States)

    Rafii, Forough; Rahimparvar, Seyedeh Fatemeh Vasegh; Mehrdad, Neda; Keramat, Afsaneh

    2017-01-01

    Risk of developing type 2 diabetes is increased in women with previous gestational diabetes mellitus (GDM). Postpartum glycemic screening is recommended in women with recent GDM. But this screening rate is low and the reasons are unclear. The aim of this study was to explore the experiences of Iranian women with recent GDM on barriers of postpartum screening for diabetes. This qualitative study was conducted in Tehran, Iran in 2016. Semi-structured interview was used for data collection. 22 women with recent GDM were interviewed. These women gave birth in Tehran hospitals at a minimum of 6 months before interview. The missed screening defined as not attending to laboratory for Fasting Blood Sugar and/or Oral Glucose Tolerance Test, 6 week to 6 month after their child birthing. The data was analyzed by content analysis method. Themes and sub-themes that illustrated the barriers to postpartum diabetes screening were: inadequate education (about developing diabetes in the future, implementation of the screening, and glucometer validity in diagnosis of diabetes), perceiving the screening as difficult (feeling comfortable with the glucometer, poor laboratory conditions, issues related to the baby/babies, and financial problems), improper attitudes toward the screening (unwilling to get diagnosed, not giving priority to oneself, having false beliefs) and procrastination (gap to intention and action, self-deception and self-regulation failure). Women with recent GDM reported several barriers for postpartum diabetes screening. This study help to develop the evidence-based interventions for improving this screening rate.

  11. A Flexible-Dose Study of Paliperidone ER in Patients With Nonacute Schizophrenia Previously Treated Unsuccessfully With Oral Olanzapine.

    Science.gov (United States)

    Kotler, Moshe; Dilbaz, Nesrin; Rosa, Fernanda; Paterakis, Periklis; Milanova, Vihra; Smulevich, Anatoly B; Lahaye, Marjolein; Schreiner, Andreas

    2016-01-01

    The goal of this study was to explore the tolerability, safety, and treatment response of switching from oral olanzapine to paliperidone extended release (ER). Adult patients with nonacute schizophrenia who had been treated unsuccessfully with oral olanzapine were switched to flexible doses of paliperidone ER (3 to 12 mg/d). The primary efficacy outcome was a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint for patients who switched medications because of lack of efficacy with olanzapine and noninferiority versus previous olanzapine treatment (mean endpoint change in PANSS total scores vs. baseline of ≤ 5 points) for patients who switched for reasons other than lack of efficacy. Safety and tolerability were assessed by monitoring adverse events, extrapyramidal symptoms, and weight change. Of 396 patients, 65.2% were men, mean age was 40.0 ± 12.0 years, and 75.5% had paranoid schizophrenia. Among the patients whose main reason for switching was lack of efficacy, an improvement in the PANSS total score of ≥ 20% occurred in 57.4% of patients. Noninferiority was confirmed for each subgroup of patients whose main reason for switching was something other than lack of efficacy. Paliperidone ER was generally well tolerated. Extrapyramidal symptoms as measured by total Extrapyramidal Symptom Rating Scale scores showed statistically significant and clinically relevant improvements at endpoint, the average weight decreased by 0.8 ± 5.2 kg at endpoint, and a clinically relevant weight gain of ≥ 7% occurred in 8.0% of patients. Paliperidone ER flexibly-dosed over 6 months was well tolerated and associated with a meaningful clinical response in patients with nonacute schizophrenia who had previously been unsuccessfully treated with oral olanzapine.

  12. Geodetic Slip Solution for the Mw=7.4 Champerico (Guatemala) Earthquake of 07 November 2012

    Science.gov (United States)

    Ellis, A. P.; DeMets, C.; Briole, P.; Molina, E.; Flores, O.; Rivera, J.; Lasserre, C.; Lyon-Caen, H.; Lord, N. E.

    2014-12-01

    As the first large subduction thrust earthquake off the coast of western Guatemala in the past several decades, the 07 November 2012 Mw=7.4 earthquake offers the first opportunity for a geodetic study of coseismic and postseismic behavior for a segment of the Middle America trench where frictional coupling makes a transition from weak coupling off the coast of El Salvador to strong coupling in southern Mexico. We use measurements at 19 continuous GPS sites in Guatemala, El Salvador, and Mexico to estimate the coseismic slip and post-seismic deformation of the November 2012 Champerico (Guatemala) earthquake. Coseismic offsets range from ~47 mm near the epicenter to El Salvador. An inversion of the geodetic data indicate that that up to ~2 m of coseismic slip occurred on a ~30 km by 30 km rupture area between ~10 and 30 km depth, encouragingly close to the global CMT epicenter. The geodetic moment of 13 x 1019 N·m and corresponding magnitude of 7.4 both agree well with independent seismological estimates. An inversion for the postseismic fault afterslip shows that the transient postseismic motions recorded at 11 GPS sites are well fit with a logarithmically decaying function. More than 70 per cent of the postseismic slip occurred at the same depth or directly downdip from the main shock epicenter. At the upper limit, afterslip that occurred within 6 months of the earthquake released energy equivalent to only ~20 per cent of the coseismic moment. The seismologically derived slip solution from Ye et al. (2012), which features more highly concentrated slip than our own, fits our GPS offsets reasonably well provided that we translate their slip centroid ~51 km to the west to a position close to our own slip centroid. The geodetic and seismologic slip solutions thus suggest bounds of 2-5 m for the peak slip along a region of the interface no larger than 30 x 30 km and possibly much smaller.

  13. Earth rotation excitation mechanisms derived from geodetic space observations

    Science.gov (United States)

    Göttl, F.; Schmidt, M.

    2009-04-01

    Earth rotation variations are caused by mass displacements and motions in the subsystems of the Earth. Via the satellite Gravity and Climate Experiment (GRACE) gravity field variations can be identified which are caused by mass redistribution in the Earth system. Therefore time variable gravity field models (GFZ RL04, CSR RL04, JPL RL04, ITG-Grace03, GRGS, ...) can be used to derive different impacts on Earth rotation. Furthermore satellite altimetry provides accurate information on sea level anomalies (AVISO, DGFI) which are caused by mass and volume changes of seawater. Since Earth rotation is solely affected by mass variations and motions the volume (steric) effect has to be reduced from the altimetric observations in order to infer oceanic contributions to Earth rotation variations. Therefore the steric effect is estimated from physical ocean parameters such as temperature and salinity changes in the oceans (WOA05, Ishii). In this study specific individual geophysical contributions to Earth rotation variations are identified by means of a multitude of accurate geodetic space observations in combination with a realistic error propagation. It will be shown that due to adjustment of altimetric and/or gravimetric solutions the results for polar motion excitations can be improved.

  14. STRUCTURAL MONITORING WITH GEODETIC SURVEY OF QUADRIFOGLIO CONDOMINIUM (LECCE

    Directory of Open Access Journals (Sweden)

    D. Costantino

    2014-01-01

    Full Text Available Monitoring buildings for moving elements has been always a problem of great importance for their conservation and preservation, as well as for risk mitigation. In particular, topographic surveying allows, through the use of the principles and instruments of the geodetic survey, to control moving points which have been identified and measured. In this study case, twelve survey campaigns were done for monitoring a building located in the city of Lecce. The condominium was built five years ago on an old quarry filled with debris to allow construction. Later in time, obviously, cracks started to appear on walls within the property, and for this legal actions were taken. The survey schema adopted has been that of triangulation/trilateration, from two vertices with known coordinates. With this methodologies four cornerstones have been identified, established with forced centering on pillars with anchor plates, connected to same number of framework points, considered stable. From these, 23 control points located on the structure with rotating prisms anchored at the same manner have been surveyed. The elaboration has been carried out by generating redundancy of the measures and compensating the values with least mean squares. The results obtained by the activity of survey and elaboration have confirmed the existence of ongoing phenomena. The causes that have generated the phenomenon have been, subsequently, investigated and have been considered attributable to the existence of a sewer pipeline and a water pipeline not properly put in place and consequently broke down due to the geological characteristics of the site.

  15. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  16. Patterns and Determinants of Treatment Seeking among Previously Untreated Psychotic Patients in Aceh Province, Indonesia: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Marthoenis Marthoenis

    2016-01-01

    Full Text Available Immediate treatment of first-episode psychosis is essential in order to achieve a positive outcome. However, Indonesian psychiatric patients often delay accessing health services, the reason for which is not yet fully understood. The current study aimed to understand patterns of treatment seeking and to reveal determinants of the delay in accessing psychiatric care among first-time user psychotic patients. Qualitative interviews were conducted with sixteen family members who accompanied the patients to a psychiatric hospital. Many families expressed beliefs that mental illness appertains to village sickness and not hospital sickness; therefore, they usually take the patients to traditional or religious healers before taking them to a health professional. They also identified various factors that potentially delay accessing psychiatric treatment: low literacy and beliefs about the cause of the illness, stigmatisation, the role of extended family, financial problems, and long distance to the psychiatric hospital. On the other hand, the family mentioned various factors related to timely help seeking, including being a well-educated family, living closer to health facilities, previous experience of successful psychotic therapy, and having more positive symptoms of psychosis. The findings call for mental health awareness campaigns in the community.

  17. A Questionnaire Study on the Attitudes and Previous Experience of Croatian Family Physicians toward their Preparedness for Disaster Management.

    Science.gov (United States)

    Pekez-Pavliško, Tanja; Račić, Maja; Jurišić, Dinka

    2018-04-01

    To explore family physicians' attitudes, previous experience and self-assessed preparedness to respond or to assist in mass casualty incidents in Croatia. The cross-sectional survey was carried out during January 2017. Study participants were recruited through a Facebook group that brings together family physicians from Croatia. They were asked to complete the questionnaire, which was distributed via google.docs. Knowledge and attitudes toward disaster preparedness were evaluated by 18 questions. Analysis of variance, Student t test and Kruskal-Wallis test t were used for statistical analysis. Risk awareness of disasters was high among respondents (M = 4.89, SD=0.450). Only 16.4 of respondents have participated in the management of disaster at the scene. The majority (73.8%) of physicians have not been participating in any educational activity dealing with disaster over the past two years. Family physicians believed they are not well prepared to participate in national (M = 3.02, SD=0.856) and local community emergency response system for disaster (M = 3.16, SD=1.119). Male physicians scored higher preparedness to participate in national emergency response system for disaster ( p =0.012), to carry out accepted triage principles used in the disaster situation ( p =0.003) and recognize differences in health assessments indicating potential exposure to specific agents ( p =0,001) compared to their female colleagues. Croatian primary healthcare system attracts many young physicians, who can be an important part of disaster and emergency management. However, the lack of experience despite a high motivation indicates a need for inclusion of disaster medicine training during undergraduate studies and annual educational activities.

  18. Previous injuries and some training characteristics predict running-related injuries in recreational runners: a prospective cohort study.

    Science.gov (United States)

    Hespanhol Junior, Luiz Carlos; Pena Costa, Leonardo Oliveira; Lopes, Alexandre Dias

    2013-12-01

    What is the incidence of running-related injuries (RRIs) in recreational runners? Which personal and training characteristics predict RRIs in recreational runners? Prospective cohort study. A total of 200 recreational runners answered a fortnightly online survey containing questions about their running routine, races, and presence of RRI. These runners were followed-up for a period of 12 weeks. The primary outcome of this study was running-related injury. The incidence of injuries was calculated taking into account the exposure to running and was expressed by RRI/1000 hours. The association between potential predictive factors and RRIs was estimated using generalised estimating equation models. A total of 84 RRIs were registered in 60 (31%) of the 191 recreational runners who completed all follow-up surveys. Of the injured runners 30% (n=18/60) developed two or more RRIs, with 5/18 (28%) being recurrences. The incidence of RRI was 10 RRI/1000 hours of running exposure. The main type of RRI observed was muscle injuries (30%, n=25/84). The knee was the most commonly affected anatomical region (19%, n=16/84). The variables associated with RRI were: previous RRI (OR 1.88, 95% CI 1.01 to 3.51), duration of training although the effect was very small (OR 1.01, 95% CI 1.00 to 1.02), speed training (OR 1.46, 95% CI 1.02 to 2.10), and interval training (OR 0.61, 95% CI 0.43 to 0.88). Physiotherapists should be aware and advise runners that past RRI and speed training are associated with increased risk of further RRI, while interval training is associated with lower risk, although these associations may not be causative. Copyright © 2013 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

  19. Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of alloexposure.

    Science.gov (United States)

    Rios, Jorge A; Schlumpf, Karen S; Kakaiya, Ram M; Triulzi, Darrell J; Roback, John D; Kleinman, Steve H; Murphy, Edward L; Gottschall, Jerome L; Carey, Patricia M

    2011-06-01

    Transfusion-related acute lung injury (TRALI) mitigation strategies include the deferral of female donors from apheresis platelet (PLT) donations and the distribution of plasma for transfusion from male donors only. We studied the implications of these policies in terms of component loss at six blood centers in the United States. We collected data from allogeneic blood donors making whole blood and blood component donations during calendar years 2006 through 2008. We analyzed the distribution of donations in terms of the sex, transfusion and pregnancy histories, and blood type. A TRALI mitigation policy that would not allow plasma from female whole blood donors to be prepared into transfusable plasma components would result in nearly a 50% reduction in the units of whole blood available for plasma manufacturing and would decrease the number of type AB plasma units that could be made from whole blood donations by the same amount. Deferral of all female apheresis PLT donors, all female apheresis PLT donors with histories of prior pregnancies, or all female apheresis PLT donors with histories of prior pregnancies and positive screening test results for antibodies to human leukocyte antigens (HLAs) will result in a loss of 37.1, 22.5, and 5.4% of all apheresis PLT donations, respectively. A TRALI mitigation policy that only defers female apheresis PLT donors with previous pregnancies and HLAs would result in an approximately 5% decrease in the inventory of apheresis PLTs, but would eliminate a large proportion of components that are associated with TRALI. © 2010 American Association of Blood Banks.

  20. PCNL - a comparative study in nonoperated and in previously operated (open nephrolithotomy/pyelolithotomy patients - a single-surgeon experience

    Directory of Open Access Journals (Sweden)

    Rahul Gupta

    2011-12-01

    Full Text Available PURPOSE: Re-procedure in patients with history of open stone surgery is usually challenging due to the alteration in the retroperitoneal anatomy. The aim of this study was to determine the possible impact of open renal surgery on the efficacy and morbidity of subsequent percutaneous nephrolithotomy (PCNL. MATERIALS AND METHODS: From March 2009 until September 2010, 120 patients underwent PCNL. Of these, 20 patients were excluded (tubeless or bilateral simultaneous PCNL. Of the remaining 100, 55 primary patients were categorized as Group 1 and the remaining (previous open nephrolithotomy as Group 2. Standard preoperative evaluation was carried out prior to intervention, Statistical analysis was performed using SPSS v. 11 with the chi-square test, independent samples t-test, and Mann-Whitney U test. A p-value < 0.05 was taken as statistically significant. RESULTS: Both groups were similar in demographic profile and stone burden. Attempts to access the PCS was less in Group 1 compared to Group 2 (1.2 + 1 2 vs 3 + 1.3 respectively and this was statistically significant (p < 0.04. However, the mean operative time between the two groups was not statistically significant (p = 0.44. Blood transfusion rate was comparable in the two groups (p = 0.24. One patient in Group 2 developed hemothorax following a supra-11th puncture. Remaining complications were comparable in both groups. CONCLUSION: Patients with past history of renal stone surgery may need more attempts to access the pelvicaliceal system and have difficulty in tract dilation secondary to retroperitoneal scarring. But overall morbidity and efficacy is same in both groups.

  1. Verification of Positional Accuracy of ZVS3003 Geodetic Control ...

    African Journals Online (AJOL)

    The International GPS Service (IGS) has provided GPS orbit products to the scientific community with increased precision and timeliness. Many users interested in geodetic positioning have adopted the IGS precise orbits to achieve centimeter level accuracy and ensure long-term reference frame stability. Positioning with ...

  2. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer: a population-based study

    Science.gov (United States)

    Fischer, Alexander H.; Wang, Timothy S.; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L.

    2016-01-01

    Background Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit UV exposure. Objective To determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. Methods We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (95% CI), taking into account the complex survey design. Results Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% versus 27.0%; aPOR=1.41; 1.16–1.71), long sleeves (20.5% versus 7.7%; aPOR=1.55; 1.21–1.98), a wide-brimmed hat (26.1% versus 10.5%; aPOR=1.52; 1.24–1.87), and sunscreen (53.7% versus 33.1%; aPOR=2.11; 95% CI=1.73–2.59), but did not have significantly lower odds of recent sunburn (29.7% versus 40.7%; aPOR=0.95; 0.77–1.17). Among subjects with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Limitations Self-reported cross-sectional data and unavailable information quantifying regular sun exposure. Conclusion Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. PMID:27198078

  3. Time Biases in laser ranging measurements; impacts on geodetic products (Reference Frame and Orbitography)

    Science.gov (United States)

    Belli, A.; Exertier, P.; Lemoine, F. G.; Chinn, D. S.; Zelensky, N. P.

    2017-12-01

    The GGOS objectives are to maintain a geodetic network with an accuracy of 1 mm and a stability of 0.1 mm per year. For years, the laser ranging technique, which provide very accurate absolute distances to geodetic targets enable to determine the scale factor as well as coordinates of the geocenter. In order to achieve this goal, systematic errors appearing in the laser ranging measurements must be considered and solved. In addition to Range Bias (RB), which is the primary source of uncertainty of the technique, Time Bias (TB) has been recently detected by using the Time Transfer by Laser Link (T2L2) space instrument capability on-board the satellite Jason-2. Instead of determining TB through the precise orbit determination that is applied to commonly used geodetic targets like LAGEOS to estimate global geodetic products, we have developed, independently, a dedicated method to transfer time between remote satellite laser ranging stations. As a result, the evolving clock phase shift to UTC of around 30 stations has been determined under the form of time series of time bias per station from 2008 to 2016 with an accuracy of 3-4 ns. It demonstrated the difficulty, in terms of Time & Frequency used technologies, to locally maintain accuracy and long term stability at least in the range of 100 ns that is the current requirement for time measurements (UTC) for the laser ranging technique. Because some laser ranging stations oftently exceed this limit (from 100 ns to a few μs) we have been studying these effects first on the precision orbit determination itself, second on the station positioning. We discuss the impact of TB on LAGEOS and Jason-2 orbits, which appears to affect the along-track component essentially. We also investigate the role of TB in global geodetic parameters as the station coordinates. Finally, we propose to provide the community with time series of time bias of laser ranging stations, under the form of a data- handling-file in order to be included in

  4. Enhanced three-dimensional stochastic adjustment for combined volcano geodetic networks

    Science.gov (United States)

    Del Potro, R.; Muller, C.

    2009-12-01

    Volcano geodesy is unquestionably a necessary technique in studies of physical volcanology and for eruption early warning systems. However, as every volcano geodesist knows, obtaining measurements of the required resolution using traditional campaigns and techniques is time consuming and requires a large manpower. Moreover, most volcano geodetic networks worldwide use a combination of data from traditional techniques; levelling, electronic distance measurements (EDM), triangulation and Global Navigation Satellite Systems (GNSS) but, in most cases, these data are surveyed, analysed and adjusted independently. This then leaves it to the authors’ criteria to decide which technique renders the most realistic results in each case. Herein we present a way of solving the problem of inter-methodology data integration in a cost-effective manner following a methodology were all the geodetic data of a redundant, combined network (e.g. surveyed by GNSS, levelling, distance, angular data, INSAR, extensometers, etc.) is adjusted stochastically within a single three-dimensional referential frame. The adjustment methodology is based on the least mean square method and links the data with its geometrical component providing combined, precise, three-dimensional, displacement vectors, relative to external reference points as well as stochastically-quantified, benchmark-specific, uncertainty ellipsoids. Three steps in the adjustment allow identifying, and hence dismissing, flagrant measurement errors (antenna height, atmospheric effects, etc.), checking the consistency of external reference points and a final adjustment of the data. Moreover, since the statistical indicators can be obtained from expected uncertainties in the measurements of the different geodetic techniques used (i.e. independent of the measured data), it is possible to run a priori simulations of a geodetic network in order to constrain its resolution, and reduce logistics, before the network is even built. In this

  5. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  6. Radioimmunotherapy with Y-90-epratuzumab in patients with previously treated B-cell lymphoma. A fractionated dose-escalation study

    International Nuclear Information System (INIS)

    Linden, O.; Cavallin-Stahl, E.; Tennvall, J.; Hindorf, C.; Olsson, T.; Strand, S.E.; Stenberg, L.; Wingardh, K.

    2002-01-01

    Aim: Fractionated RIT may improve outcome by decreasing heterogeneity in absorbed dose and by increasing therapeutic window. The humanised anti-CD22 antibody, Epratuzumab, (Immunomedics, Inc., Morris Plains, NJ) can be given repeatedly with minimal risk of neutralising Ab (HAHA), making fractionated treatment with 90 Y-labelled epratuzumab possible. Materials and Methods: Patients with previously treated B-cell lymphoma received increasing number (2-4) of weekly infusions of 90 Y-epratuzumab. Patients received either 185 MBq/m 2 per infusion (group A), or, if they had a history of high-dose chemotherapy with stem-cell rescue, 92.5 MBq/m 2 per infusion (group B). The first infusion included 150 MBq of 111 Indium for scintigraphic verification of tumour targeting and dosimetry. 1.5 mg/kg epratuzumab was administered with each infusion. The treatment could be repeated once after 3 m. Results: Of 23 patients, 16 in group A and 6 in group B were evaluable for response. The RR in group A was 62% objective response (OR) and 25% CR/CRu. One patient in group B showed OR. OR was seen in aggressive and indolent lymphoma. Response was also long-lasting and event-free survival of patients showing CR/CRu was 14 to 25+ months. In group A all seven patient, receiving three infusions, showed less than grade 3 platelet and neutrophil toxicity, except for two patients suffering grade 3 neutropenia. Of five patients with 4 weekly infusions there were two patients with dose-limiting haematological toxicity (DLT), both recently treated with high dose cytosar before RIT. With criteria used the maximal tolerated dose was three infusions 185 MBq/m 2 . In group B no patient suffered DLT and one patient exhibited OR. Seven patients were retreated after 3 months with minor toxicity, but improvement in OR in two cases. No patient has developed HAHA. CD22 expression on tumour cells, as assessed by flow cytometry, is available in 18 of 22 patients. In group A, seven of eight patients with

  7. Influence of bad measurements in properties of GeodeticNnetwork

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    Vincent Jakub

    2008-12-01

    Full Text Available In establishment of LGS (Local geodetic Net some given coordinated points from the relevant area are used, new points areestablished and the required distances and angles among the points are measured. If some measurements are defective, the netadjustment with the obtained values is depreciated, unacceptable. In the paper there is given an identification method of incorrectmeasurement results. The faulty results are eliminated in a new adjustment or the relevant defective measurements are repeated forobtaining correct values.

  8. Global Positioning System (GPS) survey of Augustine Volcano, Alaska, August 3-8, 2000: data processing, geodetic coordinates and comparison with prior geodetic surveys

    Science.gov (United States)

    Pauk, Benjamin A.; Power, John A.; Lisowski, Mike; Dzurisin, Daniel; Iwatsubo, Eugene Y.; Melbourne, Tim

    2001-01-01

    Between August 3 and 8,2000,the Alaska Volcano Observatory completed a Global Positioning System (GPS) survey at Augustine Volcano, Alaska. Augustine is a frequently active calcalkaline volcano located in the lower portion of Cook Inlet (fig. 1), with reported eruptions in 1812, 1882, 1909?, 1935, 1964, 1976, and 1986 (Miller et al., 1998). Geodetic measurements using electronic and optical surveying techniques (EDM and theodolite) were begun at Augustine Volcano in 1986. In 1988 and 1989, an island-wide trilateration network comprising 19 benchmarks was completed and measured in its entirety (Power and Iwatsubo, 1998). Partial GPS surveys of the Augustine Island geodetic network were completed in 1992 and 1995; however, neither of these surveys included all marks on the island.Additional GPS measurements of benchmarks A5 and A15 (fig. 2) were made during the summers of 1992, 1993, 1994, and 1996. The goals of the 2000 GPS survey were to:1) re-measure all existing benchmarks on Augustine Island using a homogeneous set of GPS equipment operated in a consistent manner, 2) add measurements at benchmarks on the western shore of Cook Inlet at distances of 15 to 25 km, 3) add measurements at an existing benchmark (BURR) on Augustine Island that was not previously surveyed, and 4) add additional marks in areas of the island thought to be actively deforming. The entire survey resulted in collection of GPS data at a total of 24 sites (fig. 1 and 2). In this report we describe the methods of GPS data collection and processing used at Augustine during the 2000 survey. We use this data to calculate coordinates and elevations for all 24 sites surveyed. Data from the 2000 survey is then compared toelectronic and optical measurements made in 1988 and 1989. This report also contains a general description of all marks surveyed in 2000 and photographs of all new marks established during the 2000 survey (Appendix A).

  9. A case study of IMRT planning (Plan B) subsequent to a previously treated IMRT plan (Plan A)

    International Nuclear Information System (INIS)

    2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Cao, F; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Leong, C; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Schroeder, J; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Lee, B

    2014-01-01

    Background and purpose: Treatment of the contralateral neck after previous ipsilateral intensity modulated radiation therapy (IMRT) for head and neck cancer is a challenging problem. We have developed a technique that limits the cumulative dose to the spinal cord and brainstem while maximizing coverage of a planning target volume (PTV) in the contralateral neck. Our case involves a patient with right tonsil carcinoma who was given ipsilateral IMRT with 70Gy in 35 fractions (Plan A). A left neck recurrence was detected 14 months later. The patient underwent a neck dissection followed by postoperative left neck radiation to a dose of 66 Gy in 33 fractions (Plan B). Materials and Methods: The spinal cord-brainstem margin (SCBM) was defined as the spinal cord and brainstem with a 1.0 cm margin. Plan A was recalculated on the postoperative CT scan but the fluence outside of SCBM was deleted. A further modification of Plan A resulted in a base plan that was summed with Plan B to evaluate the cumulative dose received by the spinal cord and brainstem. Plan B alone was used to evaluate for coverage of the contralateral neck PTV. Results: The maximum cumulative doses to the spinal cord with 0.5cm margin and brainstem with 0.5cm margin were 51.96 Gy and 45.60 Gy respectively. For Plan B, 100% of the prescribed dose covered 95% of PTVb1. Conclusion: The use of a modified ipsilateral IMRT plan as a base plan is an effective way to limit the cumulative dose to the spinal cord and brainstem while enabling coverage of a PTV in the contralateral neck.

  10. Evaluation of a rapid dipstick (Crystal VC for the diagnosis of cholera in Zanzibar and a comparison with previous studies.

    Directory of Open Access Journals (Sweden)

    Benedikt Ley

    Full Text Available The gold standard for the diagnosis of cholera is stool culture, but this requires laboratory facilities and takes at least 24 hours. A rapid diagnostic test (RDT that can be used by minimally trained staff at treatment centers could potentially improve the reporting and management of cholera outbreaks.We evaluated the Crystal VC™ RDT under field conditions in Zanzibar in 2009. Patients presenting to treatment centers with watery diarrhea provided a stool sample for rapid diagnostic testing. Results were compared to stool culture performed in a reference laboratory. We assessed the overall performance of the RDT and evaluated whether previous intake of antibiotics, intravenous fluids, location of testing, and skill level of the technician affected the RDT results.We included stool samples from 624 patients. Compared to culture, the overall sensitivity of the RDT was 93.1% (95%CI: 88.7 to 96.2%, specificity was 49.2% (95%CI: 44.3 to 54.1%, the positive predictive value was 47.0% (95%CI: 42.1 to 52.0% and the negative predictive value was 93.6% (95%CI: 89.6 to 96.5%. The overall false positivity rate was 50.8% (213/419; fieldworkers frequently misread very faint test lines as positive.The observed sensitivity of the Crystal VC RDT evaluated was similar compared to earlier versions, while specificity was poorer. The current version of the RDT could potentially be used as a screening tool in the field. Because of the high proportion of false positive results when field workers test stool specimens, positive results will need to be confirmed with stool culture.

  11. Regional Crustal Deformation and Lithosphere Thickness Observed with Geodetic Techniques

    Science.gov (United States)

    Vermeer, M.; Poutanen, M.; Kollo, K.; Koivula, H.; Ahola, J.

    2009-04-01

    The solid Earth, including the lithosphere, interacts in many ways with other components of the Earth system, oceans, atmosphere and climate. Geodesy is a key provider of data needed for global and environmental research. Geodesy provides methods and accurate measurements of contemporary deformation, sea level and gravity change. The importance of the decades-long stability and availability of reference frames must be stressed for such studies. In the future, the need to accurately monitor 3-D crustal motions will grow, both together with increasingly precise GNSS (Global Navigation Satellite System) positioning, demands for better follow-up of global change, and local needs for crustal motions, especially in coastal areas. These demands cannot yet be satisfied. The project described here is a part of a larger entity: Upper Mantle Dynamics and Quaternary Climate in Cratonic Areas, DynaQlim, an International Lithosphere Project (ILP) -sponsored initiative. The aims of DynaQlim are to understand the relations between upper mantle dynamics, mantle composition, physical properties, temperature and rheology, to study the postglacial uplift and ice thickness models, sea level change and isostatic response, Quaternary climate variations and Weichselian (Laurentian and other) glaciations during the late Quaternary. We aim at studying various aspects of lithospheric motion within the Finnish and Fennoscandian area, but within a global perspective, by the newest geodetic techniques in a multidisciplinary setting. The studies involve observations of three-dimensional motions and gravity change in a multidisciplinary context on a range of spatial scales: the whole of Fennoscandia, Finland, a regional test area of Satakunta, and the local test site Olkiluoto. Objectives of the research include improving our insight into the 3-D motion of a thick lithosphere, and into the gravity effect of the uplift, using novel approaches; improving the kinematic 3-D models in the

  12. Space Geodetic Technique Co-location in Space: Simulation Results for the GRASP Mission

    Science.gov (United States)

    Kuzmicz-Cieslak, M.; Pavlis, E. C.

    2011-12-01

    The Global Geodetic Observing System-GGOS, places very stringent requirements in the accuracy and stability of future realizations of the International Terrestrial Reference Frame (ITRF): an origin definition at 1 mm or better at epoch and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale (0.1 ppb) and orientation components. These goals were derived from the requirements of Earth science problems that are currently the international community's highest priority. None of the geodetic positioning techniques can achieve this goal alone. This is due in part to the non-observability of certain attributes from a single technique. Another limitation is imposed from the extent and uniformity of the tracking network and the schedule of observational availability and number of suitable targets. The final limitation derives from the difficulty to "tie" the reference points of each technique at the same site, to an accuracy that will support the GGOS goals. The future GGOS network will address decisively the ground segment and to certain extent the space segment requirements. The JPL-proposed multi-technique mission GRASP (Geodetic Reference Antenna in Space) attempts to resolve the accurate tie between techniques, using their co-location in space, onboard a well-designed spacecraft equipped with GNSS receivers, a SLR retroreflector array, a VLBI beacon and a DORIS system. Using the anticipated system performance for all four techniques at the time the GGOS network is completed (ca 2020), we generated a number of simulated data sets for the development of a TRF. Our simulation studies examine the degree to which GRASP can improve the inter-technique "tie" issue compared to the classical approach, and the likely modus operandi for such a mission. The success of the examined scenarios is judged by the quality of the origin and scale definition of the resulting TRF.

  13. Cansiglio Karst Plateau: 10 Years of Geodetic-Hydrological Observations in Seismically Active Northeast Italy

    Science.gov (United States)

    Grillo, Barbara; Braitenberg, Carla; Nagy, Ildikó; Devoti, Roberto; Zuliani, David; Fabris, Paolo

    2018-04-01

    Ten years' geodetic observations (2006-2016) in a natural cave of the Cansiglio Plateau (Bus de la Genziana), a limestone karstic area in northeastern Italy, are discussed. The area is of medium-high seismic risk: a strong earthquake in 1936 below the plateau (M m = 6.2) and the 1976 disastrous Friuli earthquake (M m = 6.5) are recent events. At the foothills of the karstic massif, three springs emerge, with average flow from 5 to 10 m3/s, and which are the sources of a river. The tiltmeter station is set in a natural cavity that is part of a karstic system. From March 2013, a multiparametric logger (temperature, stage, electrical conductivity) was installed in the siphon at the bottom of the cave to discover the underground hydrodynamics. The tilt records include signals induced by hydrologic and tectonic effects. The tiltmeter signals have a clear correlation to the rainfall, the discharge series of the river and the data recorded by multiparametric loggers. Additionally, the data of a permanent GPS station located on the southern slopes of the Cansiglio Massif (CANV) show also a clear correspondence with the river level. The fast water infiltration into the epikarst, closely related to daily rainfall, is distinguished in the tilt records from the characteristic time evolution of the karstic springs, which have an impulsive level increase with successive exponential decay. It demonstrates the usefulness of geodetic measurements to reveal the hydrological response of the karst. One outcome of the work is that the tiltmeters can be used as proxies for the presence of flow channels and the pressure that builds up due to the water flow. With 10 years of data, a new multidisciplinary frontier was opened between the geodetic studies and the karstic hydrogeology to obtain a more complete geologic description of the karst plateau.

  14. The Global Geodetic Observing System: Space Geodesy Networks for the Future

    Science.gov (United States)

    Pearlman, Michael; Pavlis, Erricos; Ma, Chopo; Altamini, Zuheir; Noll, Carey; Stowers, David

    2011-01-01

    Ground-based networks of co-located space geodetic techniques (VLBI, SLR, GNSS. and DORIS) are the basis for the development and maintenance of the International Terrestrial Reference frame (ITRF), which is our metric of reference for measurements of global change, The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) has established a task to develop a strategy to design, integrate and maintain the fundamental geodetic network and supporting infrastructure in a sustainable way to satisfy the long-term requirements for the reference frame. The GGOS goal is an origin definition at 1 mm or better and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale and orientation components. These goals are based on scientific requirements to address sea level rise with confidence, but other applications are not far behind. Recent studies including one by the US National Research Council has strongly stated the need and the urgency for the fundamental space geodesy network. Simulations are underway to examining accuracies for origin, scale and orientation of the resulting ITRF based on various network designs and system performance to determine the optimal global network to achieve this goal. To date these simulations indicate that 24 - 32 co-located stations are adequate to define the reference frame and a more dense GNSS and DORIS network will be required to distribute the reference frame to users anywhere on Earth. Stations in the new global network will require geologically stable sites with good weather, established infrastructure, and local support and personnel. GGOS wil seek groups that are interested in participation. GGOS intends to issues a Call for Participation of groups that would like to contribute in the network implementation and operation. Some examples of integrated stations currently in operation or under development will be presented. We will examine necessary conditions and challenges in

  15. Precise Orbital and Geodetic Parameter Estimation using SLR Observations for ILRS AAC

    Directory of Open Access Journals (Sweden)

    Young-Rok Kim

    2013-12-01

    Full Text Available In this study, we present results of precise orbital geodetic parameter estimation using satellite laser ranging (SLR observations for the International Laser Ranging Service (ILRS associate analysis center (AAC. Using normal point observations of LAGEOS-1, LAGEOS-2, ETALON-1, and ETALON-2 in SLR consolidated laser ranging data format, the NASA/ GSFC GEODYN II and SOLVE software programs were utilized for precise orbit determination (POD and finding solutions of a terrestrial reference frame (TRF and Earth orientation parameters (EOPs. For POD, a weekly-based orbit determination strategy was employed to process SLR observations taken from 20 weeks in 2013. For solutions of TRF and EOPs, loosely constrained scheme was used to integrate POD results of four geodetic SLR satellites. The coordinates of 11 ILRS core sites were determined and daily polar motion and polar motion rates were estimated. The root mean square (RMS value of post-fit residuals was used for orbit quality assessment, and both the stability of TRF and the precision of EOPs by external comparison were analyzed for verification of our solutions. Results of post-fit residuals show that the RMS of the orbits of LAGEOS-1 and LAGEOS-2 are 1.20 and 1.12 cm, and those of ETALON-1 and ETALON-2 are 1.02 and 1.11 cm, respectively. The stability analysis of TRF shows that the mean value of 3D stability of the coordinates of 11 ILRS core sites is 7.0 mm. An external comparison, with respect to International Earth rotation and Reference systems Service (IERS 08 C04 results, shows that standard deviations of polar motion Xp and Yp are 0.754 milliarcseconds (mas and 0.576 mas, respectively. Our results of precise orbital and geodetic parameter estimation are reasonable and help advance research at ILRS AAC.

  16. ESPACE - a geodetic Master's program for the education of Satellite Application Engineers

    Science.gov (United States)

    Hedman, K.; Kirschner, S.; Seitz, F.

    2012-04-01

    In the last decades there has been a rapid development of new geodetic and other Earth observation satellites. Applications of these satellites such as car navigation systems, weather predictions, and, digital maps (such as Google Earth or Google Maps) play a more and more important role in our daily life. For geosciences, satellite applications such as remote sensing and precise positioning/navigation have turned out to be extremely useful and are meanwhile indispensable. Today, researchers within geodesy, climatology, oceanography, meteorology as well as within Earth system science are all dependent on up-to-date satellite data. Design, development and handling of these missions require experts with knowledge not only in space engineering, but also in the specific applications. That gives rise to a new kind of engineers - satellite application engineers. The study program for these engineers combines parts of different classical disciplines such as geodesy, aerospace engineering or electronic engineering. The satellite application engineering program Earth Oriented Space Science and Technology (ESPACE) was founded in 2005 at the Technische Universität München, mainly from institutions involved in geodesy and aerospace engineering. It is an international, interdisciplinary Master's program, and is open to students with a BSc in both Science (e.g. Geodesy, Mathematics, Informatics, Geophysics) and Engineering (e.g. Aerospace, Electronical and Mechanical Engineering). The program is completely conducted in English. ESPACE benefits from and utilizes its location in Munich with its unique concentration of expertise related to space science and technology. Teaching staff from 3 universities (Technische Universität München, Ludwig-Maximilian University, University of the Federal Armed Forces), research institutions (such as the German Aerospace Center, DLR and the German Geodetic Research Institute, DGFI) and space industry (such as EADS or Kayser-Threde) are

  17. Studies in iodine metabolism: 33 year summary, 1948-1979 (as previously submitted) with appendix, 1979-1982

    International Nuclear Information System (INIS)

    Middlesworth, L.V.

    1982-01-01

    The results of research into iodine metabolism from 1948 to 1982 are summarized. Study areas included the monitoring of iodine 131 from fallout in the thyroid glands of cattle and humans, the biological functions and metabolism of thyroid hormones, and methods to reduce the retention of radioiodine in the thyroid

  18. CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.

    Science.gov (United States)

    Goujon, Catherine; Gougeon, Marie-Lise; Tondeur, Laura; Poirier, Béatrice; Seffer, Valérie; Desprès, Philippe; Consigny, Paul-Henri; Vray, Muriel

    2017-10-27

    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area. A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Cases were defined as infants immunized with the yellow fever vaccine and with the measles vaccine, either alone or in combination with mumps and rubella vaccine, with a period of 1-27days between each immunization. For each case, two controls were matched based on sex and age: a first control group (control 1) was defined as infants having received the measles vaccine and the yellow fever vaccine simultaneously; a second control group (control 2) was defined as infants who had a period of more than 27days between receiving the measles vaccine and yellow fever vaccine. The primary endpoint of the study was the percentage of infants with protective immunity against yellow fever, measured by the titer of neutralizing antibodies in a venous blood sample. One hundred and thirty-one infants were included in the study (62 cases, 50 infants in control 1 and 19 infants in control 2). Of these, 127 (96%) were shown to have a protective titer of yellow fever antibodies. All 4 infants without a protective titer of yellow fever antibodies were part of control group 1. The measles vaccine, alone or combined with mumps and rubella vaccines, appears to have no influence on humoral immune response to the yellow fever vaccine when administered between 1 and 27

  19. Structural Study and Evaluation of Previous Restoration Work of Mohammad 'Ali Pasha Mosque at the Citadel in Cairo

    Directory of Open Access Journals (Sweden)

    dr.Yaser Yehya Amin Abdel-Aty

    2011-01-01

    Full Text Available Mohammad 'Ali Pasha Mosque at the Citadel in Cairo is considered one of the main landmarks in Egypt. It majestically stands at a northwestern bend of the Citadel and it is visible from numerous locations in Cairo. It has become the symbol of the Citadel, to the point that its name is given to the whole complex in the colloquial Egyptian parlance. This paper studies analytically the static and dynamic structural behavior of this great mosque using computer numerical modeling techniques, to reach the main reasons for past cracking and failures in its domed-roof and other structural elements, which occurred by the end of 19th Century. A number of 3D-models are analyzed to study the mosque, in both original and after restoration conditions, under static (i.e. dead and live loads and dynamic (i.e. Eigenvector modal analysis, response-spectrum and time-history cases of loading. Besides, structural evaluation of major restoration project, in 1930s, is conducted to determine the current structural safety status of the mosque

  20. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media.

    Science.gov (United States)

    Morel, Mike E; McBride, Simon E; Gomez, Maria P

    2017-12-01

    The suitability and stability of cervical cells in Novaprep media (NHQ) for certain HPV assays is unknown. We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV) for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months' stability at 18-25°C, 2-8°C, -20°C and -80°C; and at least 3 months' stability at 40°C. Similar results were obtained for pre-treated NHQ except only 3.5 months' stability at 18-25°C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media

    Directory of Open Access Journals (Sweden)

    Mike E. Morel

    2017-12-01

    Full Text Available Background: The suitability and stability of cervical cells in Novaprep media (NHQ for certain HPV assays is unknown. Methods: We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Results: Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months’ stability at 18–25 °C, 2–8 °C, −20 °C and −80 °C; and at least 3 months’ stability at 40 °C. Similar results were obtained for pre-treated NHQ except only 3.5 months’ stability at 18–25 °C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Conclusions: Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Keywords: HPV, Preservative, Sample stability, Automated HR HPV assay

  2. Large earthquake rates from geologic, geodetic, and seismological perspectives

    Science.gov (United States)

    Jackson, D. D.

    2017-12-01

    Earthquake rate and recurrence information comes primarily from geology, geodesy, and seismology. Geology gives the longest temporal perspective, but it reveals only surface deformation, relatable to earthquakes only with many assumptions. Geodesy is also limited to surface observations, but it detects evidence of the processes leading to earthquakes, again subject to important assumptions. Seismology reveals actual earthquakes, but its history is too short to capture important properties of very large ones. Unfortunately, the ranges of these observation types barely overlap, so that integrating them into a consistent picture adequate to infer future prospects requires a great deal of trust. Perhaps the most important boundary is the temporal one at the beginning of the instrumental seismic era, about a century ago. We have virtually no seismological or geodetic information on large earthquakes before then, and little geological information after. Virtually all-modern forecasts of large earthquakes assume some form of equivalence between tectonic- and seismic moment rates as functions of location, time, and magnitude threshold. That assumption links geology, geodesy, and seismology, but it invokes a host of other assumptions and incurs very significant uncertainties. Questions include temporal behavior of seismic and tectonic moment rates; shape of the earthquake magnitude distribution; upper magnitude limit; scaling between rupture length, width, and displacement; depth dependence of stress coupling; value of crustal rigidity; and relation between faults at depth and their surface fault traces, to name just a few. In this report I'll estimate the quantitative implications for estimating large earthquake rate. Global studies like the GEAR1 project suggest that surface deformation from geology and geodesy best show the geography of very large, rare earthquakes in the long term, while seismological observations of small earthquakes best forecasts moderate earthquakes

  3. Monitoring of Volcanic Activity by Sub-mm Geodetic Analyses

    Science.gov (United States)

    Miura, S.; Mare, Y.; Ichiki, M.; Demachi, T.; Tachibana, K.; Nishimura, T.

    2017-12-01

    Volcanic earthquakes have been occurring beneath Zao volcano in northern Honshu, Japan since 2013, following the increase of deep low frequency earthquakes from 2012. On account of a burst of seismicity initiated in April 2015, the JMA announced a warning of eruption, however, the seismicity gradually decreased for the next two months and the warning was canceled in June. In the same time period, minor expansive deformation was observed by GNSS. Small earthquakes are still occurring, and low-freq. earthquakes (LPE) occur sometimes accompanied by static tilt changes. In this study, we try to extract the sub-mm displacements from the LPE waveforms observed by broadband seismometers (BBS) and utilize them for geodetic inversion to monitor volcanic activities. Thun et al. (2015, 2016) devised an efficient method using a running median filter (RMF) to remove LP noises, which contaminate displacement waveforms. They demonstrated the reproducibility of the waveforms corresponding to the experimentally given sub-mm displacements in the laboratory. They also apply the method to the field LPE data obtained from several volcanoes to show static displacements. The procedure is outlined as follows: (1) Unfiltered removal of the instrument response, (2) LP noise estimate by LPF with a corner frequency of 5/M, where M (seconds) is the time window of the RMF and should be at least three times the length of the rise time. (3) Subtract the noise estimated from step (2). (4) Integrate to obtain displacement waveforms. We apply the method to the BBS waveform at a distance of about 1.5 km ESE from the summit crater of Zao Volcano associated with a LPE on April 1, 2017. Assuming the time window M as 300 seconds, we successfully obtained the displacement history: taking the rise time of about 2 minutes, the site was gradually uplifted with the amount of about 50-60 µm and then subsided with HF displacements in the next 2 minutes resulting about 20-30 µm static upheaval. Comparing the

  4. The current state of the creation and modernization of national geodetic and cartographic resources in Poland

    Directory of Open Access Journals (Sweden)

    Doskocz Adam

    2016-01-01

    Full Text Available All official data are currently integrated and harmonized in a spatial reference system. This paper outlines a national geodetic and cartographic resources in Poland. The national geodetic and cartographic resources are an important part of the spatial information infrastructure in the European Community. They also provide reference data for other resources of Spatial Data Infrastructure (SDI, including: main and detailed geodetic control networks, base maps, land and buildings registries, geodetic registries of utilities and topographic maps. This paper presents methods of producing digital map data and technical standards for field surveys, and in addition paper also presents some aspects of building Global and Regional SDI.

  5. An Autonomous, Low Cost Platform for Seafloor Geodetic Observations

    Science.gov (United States)

    Ericksen, T.; Foster, J. H.; Bingham, B. S.

    2013-12-01

    The high cost of acquiring geodetic data from the sea floor has limited the observations available to help us understand and model the behavior of seafloor geodetic processes. To address this problem, the Pacific GPS Facility at the University of Hawaii is developing a cost effective approach for accurately measuring short-term vertical motions of the seafloor and maintaining a continuous long-term record of seafloor pressure without the requirement for costly ship time. There is a recognized need to vastly increase our underwater geodetic observing capacity. Most of the largest recorded earthquakes and most devastating tsunamis are generated at subduction zones underwater. Similarly, many volcanoes are partly (e.g. Santorini) or completely (e.g. Loihi) submerged, and are not well observed and understood. Furthermore, landslide features ring many ocean basins, and huge debris deposits surround many volcanic oceanic islands. Our approach will lower the cost of collecting sea-floor geodetic data, reducing the barriers preventing us from acquiring the information we need to observe and understand these types of structures and provide a direct societal benefit in improving hazard assessment. The capability is being developed by equipping one of the University of Hawaii Wave Gliders with an integrated acoustic telemetry package, a dual frequency geodetic-grade Global Positioning System (GPS) receiver, processing unit, and cellular communications. The Wave Glider will interrogate high accuracy pressure sensors on the sea floor to maintain a near-continuous stream of pressure and temperature data, but seafloor pressure data includes contribution from a variety of sources and on its own may not provide the accuracy required for geodetic investigations. Independent measurements of sea surface pressure and sea surface height can be used to remove these contributions from the observed sea floor pressure timeseries. We will integrate our seafloor pressure measurements with air

  6. Aspects Regarding the Establishment of the Scale Coefficient in the Case of Distances Measurements in an Geodetic Network

    Directory of Open Access Journals (Sweden)

    Mircea Ortelecan

    2016-11-01

    Full Text Available The paper analyzes the possibility to establish the coefficient of scale towards the total station scale triangulation network in the conduct of geodetic and topographic observations in the points with known coordinates (old points or points whose coordinates we want to determine (new points. The purpose of the study is undertaken to simplify computing operations to reduce distances measured from the topographic surface to the Stereo 70 projection plan.

  7. Slip deficit on the san andreas fault at parkfield, california, as revealed by inversion of geodetic data.

    Science.gov (United States)

    Segall, P; Harris, R

    1986-09-26

    A network of geodetic lines spanning the San Andreas fault near the rupture zone of the 1966 Parkfield, California, earthquake (magnitude M = 6) has been repeatedly surveyed since 1959. In the study reported here the average rates of line-length change since 1966 were inverted to determine the distribution of interseismic slip rate on the fault. These results indicate that the Parkfield rupture surface has not slipped significantly since 1966. Comparison of the geodetically determined seismic moment of the 1966 earthquake with the interseismic slip-deficit rate suggests that the strain released by the latest shock will most likely be restored between 1984 and 1989, although this may not occur until 1995. These results lend independent support to the earlier forecast of an M = 6 earthquake near Parkfield within 5 years of 1988.

  8. Geodetic Space Weather Monitoring by means of Ionosphere Modelling

    Science.gov (United States)

    Schmidt, Michael

    2017-04-01

    The term space weather indicates physical processes and phenomena in space caused by radiation of energy mainly from the Sun. Manifestations of space weather are (1) variations of the Earth's magnetic field, (2) the polar lights in the northern and southern hemisphere, (3) variations within the ionosphere as part of the upper atmosphere characterized by the existence of free electrons and ions, (4) the solar wind, i.e. the permanent emission of electrons and photons, (5) the interplanetary magnetic field, and (6) electric currents, e.g. the van Allen radiation belt. It can be stated that ionosphere disturbances are often caused by so-called solar storms. A solar storm comprises solar events such as solar flares and coronal mass ejections (CMEs) which have different effects on the Earth. Solar flares may cause disturbances in positioning, navigation and communication. CMEs can effect severe disturbances and in extreme cases damages or even destructions of modern infrastructure. Examples are interruptions to satellite services including the global navigation satellite systems (GNSS), communication systems, Earth observation and imaging systems or a potential failure of power networks. Currently the measurements of solar satellite missions such as STEREO and SOHO are used to forecast solar events. Besides these measurements the Earth's ionosphere plays another key role in monitoring the space weather, because it responses to solar storms with an increase of the electron density. Space-geodetic observation techniques, such as terrestrial GNSS, satellite altimetry, space-borne GPS (radio occultation), DORIS and VLBI provide valuable global information about the state of the ionosphere. Additionally geodesy has a long history and large experience in developing and using sophisticated analysis and combination techniques as well as empirical and physical modelling approaches. Consequently, geodesy is predestinated for strongly supporting space weather monitoring via

  9. Determining Coastal Mean Dynamic Topography by Geodetic Methods

    Science.gov (United States)

    Huang, Jianliang

    2017-11-01

    In geodesy, coastal mean dynamic topography (MDT) was traditionally determined by spirit leveling technique. Advances in navigation satellite positioning (e.g., GPS) and geoid determination enable space-based leveling with an accuracy of about 3 cm at tide gauges. Recent CryoSat-2, a satellite altimetry mission with synthetic aperture radar (SAR) and SAR interferometric measurements, extends the space-based leveling to the coastal ocean with the same accuracy. However, barriers remain in applying the two space-based geodetic methods for MDT determination over the coastal ocean because current geoid modeling focuses primarily on land as a substitute to spirit leveling to realize the vertical datum.

  10. Research in Application of Geodetic GPS Receivers in Time Synchronization

    Science.gov (United States)

    Zhang, Q.; Zhang, P.; Sun, Z.; Wang, F.; Wang, X.

    2018-04-01

    In recent years, with the development of satellite orbit and clock parameters accurately determining technology and the popularity of geodetic GPS receivers, Common-View (CV) which proposed in 1980 by Allan has gained widespread application and achieved higher accuracy time synchronization results. GPS Common View (GPS CV) is the technology that based on multi-channel geodetic GPS receivers located in different place and under the same common-view schedule to receiving same GPS satellite signal at the same time, and then calculating the time difference between respective local receiver time and GPST by weighted theory, we will obtain the difference between above local time of receivers that installed in different station with external atomic clock. Multi-channel geodetic GPS receivers have significant advantages such as higher stability, higher accuracy and more common-view satellites in long baseline time synchronization application over the single-channel geodetic GPS receivers. At present, receiver hardware delay and surrounding environment influence are main error factors that affect the accuracy of GPS common-view result. But most error factors will be suppressed by observation data smoothing and using of observation data from different satellites in multi-channel geodetic GPS receiver. After the SA (Selective Availability) cancellation, using a combination of precise satellite ephemeris, ionospheric-free dual-frequency P-code observations and accurately measuring of receiver hardware delay, we can achieve time synchronization result on the order of nanoseconds (ns). In this paper, 6 days observation data of two IGS core stations with external atomic clock (PTB, USNO distance of two stations about 6000 km) were used to verify the GPS common-view theory. Through GPS observation data analysis, there are at least 2-4 common-view satellites and 5 satellites in a few tracking periods between two stations when the elevation angle is 15°, even there will be at least

  11. RESEARCH IN APPLICATION OF GEODETIC GPS RECEIVERS IN TIME SYNCHRONIZATION

    Directory of Open Access Journals (Sweden)

    Q. Zhang

    2018-04-01

    Full Text Available In recent years, with the development of satellite orbit and clock parameters accurately determining technology and the popularity of geodetic GPS receivers, Common-View (CV which proposed in 1980 by Allan has gained widespread application and achieved higher accuracy time synchronization results. GPS Common View (GPS CV is the technology that based on multi-channel geodetic GPS receivers located in different place and under the same common-view schedule to receiving same GPS satellite signal at the same time, and then calculating the time difference between respective local receiver time and GPST by weighted theory, we will obtain the difference between above local time of receivers that installed in different station with external atomic clock. Multi-channel geodetic GPS receivers have significant advantages such as higher stability, higher accuracy and more common-view satellites in long baseline time synchronization application over the single-channel geodetic GPS receivers. At present, receiver hardware delay and surrounding environment influence are main error factors that affect the accuracy of GPS common-view result. But most error factors will be suppressed by observation data smoothing and using of observation data from different satellites in multi-channel geodetic GPS receiver. After the SA (Selective Availability cancellation, using a combination of precise satellite ephemeris, ionospheric-free dual-frequency P-code observations and accurately measuring of receiver hardware delay, we can achieve time synchronization result on the order of nanoseconds (ns. In this paper, 6 days observation data of two IGS core stations with external atomic clock (PTB, USNO distance of two stations about 6000 km were used to verify the GPS common-view theory. Through GPS observation data analysis, there are at least 2–4 common-view satellites and 5 satellites in a few tracking periods between two stations when the elevation angle is 15°, even

  12. The University, the Market, and the Geodetic Engineer or

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2002-01-01

    In Europe, universities have existed for more than 800 years. The university is the place in society for higher learning and related research. Through the ages, the universities have enjoyed a remarkably freedom relative to religious and secular powers. In recent years, the objectives and practises...... project, which concerned the education of geodetic engineers in Slovenia. The body of the paper presents a selection of ideas that shaped the university through the centuries, with a view to balance the present interest in advancing market-directed behaviour....

  13. Simulations of VLBI observations of a geodetic satellite providing co-location in space

    Science.gov (United States)

    Anderson, James M.; Beyerle, Georg; Glaser, Susanne; Liu, Li; Männel, Benjamin; Nilsson, Tobias; Heinkelmann, Robert; Schuh, Harald

    2018-02-01

    We performed Monte Carlo simulations of very-long-baseline interferometry (VLBI) observations of Earth-orbiting satellites incorporating co-located space-geodetic instruments in order to study how well the VLBI frame and the spacecraft frame can be tied using such measurements. We simulated observations of spacecraft by VLBI observations, time-of-flight (TOF) measurements using a time-encoded signal in the spacecraft transmission, similar in concept to precise point positioning, and differential VLBI (D-VLBI) observations using angularly nearby quasar calibrators to compare their relative performance. We used the proposed European Geodetic Reference Antenna in Space (E-GRASP) mission as an initial test case for our software. We found that the standard VLBI technique is limited, in part, by the present lack of knowledge of the absolute offset of VLBI time to Coordinated Universal Time at the level of microseconds. TOF measurements are better able to overcome this problem and provide frame ties with uncertainties in translation and scale nearly a factor of three smaller than those yielded from VLBI measurements. If the absolute time offset issue can be resolved by external means, the VLBI results can be significantly improved and can come close to providing 1 mm accuracy in the frame tie parameters. D-VLBI observations with optimum performance assumptions provide roughly a factor of two higher uncertainties for the E-GRASP orbit. We additionally simulated how station and spacecraft position offsets affect the frame tie performance.

  14. NEAR REAL-TIME DETERMINATION OF EARTHQUAKE SOURCE PARAMETERS FOR TSUNAMI EARLY WARNING FROM GEODETIC OBSERVATIONS

    Directory of Open Access Journals (Sweden)

    S. Manneela

    2016-06-01

    Full Text Available Exemplifying the tsunami source immediately after an earthquake is the most critical component of tsunami early warning, as not every earthquake generates a tsunami. After a major under sea earthquake, it is very important to determine whether or not it has actually triggered the deadly wave. The near real-time observations from near field networks such as strong motion and Global Positioning System (GPS allows rapid determination of fault geometry. Here we present a complete processing chain of Indian Tsunami Early Warning System (ITEWS, starting from acquisition of geodetic raw data, processing, inversion and simulating the situation as it would be at warning center during any major earthquake. We determine the earthquake moment magnitude and generate the centroid moment tensor solution using a novel approach which are the key elements for tsunami early warning. Though the well established seismic monitoring network, numerical modeling and dissemination system are currently capable to provide tsunami warnings to most of the countries in and around the Indian Ocean, the study highlights the critical role of geodetic observations in determination of tsunami source for high-quality forecasting.

  15. Geodetic reanalysis of annual glaciological mass balances (2001-2011) of Hintereisferner, Austria

    Science.gov (United States)

    Klug, Christoph; Bollmann, Erik; Galos, Stephan Peter; Nicholson, Lindsey; Prinz, Rainer; Rieg, Lorenzo; Sailer, Rudolf; Stötter, Johann; Kaser, Georg

    2018-03-01

    This study presents a reanalysis of the glaciologically obtained annual glacier mass balances at Hintereisferner, Ötztal Alps, Austria, for the period 2001-2011. The reanalysis is accomplished through a comparison with geodetically derived mass changes, using annual high-resolution airborne laser scanning (ALS). The grid-based adjustments for the method-inherent differences are discussed along with associated uncertainties and discrepancies of the two methods of mass balance measurements. A statistical comparison of the two datasets shows no significant difference for seven annual, as well as the cumulative, mass changes over the 10-year record. Yet, the statistical view hides significant differences in the mass balance years 2002/03 (glaciological minus geodetic records = +0.92 m w.e.), 2005/06 (+0.60 m w.e.), and 2006/07 (-0.45 m w.e.). We conclude that exceptional meteorological conditions can render the usual glaciological observational network inadequate. Furthermore, we consider that ALS data reliably reproduce the annual mass balance and can be seen as validation or calibration tools for the glaciological method.

  16. Contribution of SELENE-2 geodetic measurements to constrain the lunar internal structure

    Science.gov (United States)

    Matsumoto, K.; Kikuchi, F.; Yamada, R.; Iwata, T.; Kono, Y.; Tsuruta, S.; Hanada, H.; Goossens, S. J.; Ishihara, Y.; Kamata, S.; Sasaki, S.

    2012-12-01

    Internal structure and composition of the Moon provide important clue and constraints on theories for how the Moon formed and evolved. The Apollo seismic network has contributed to the internal structure modeling. Efforts have been made to detect the lunar core from the noisy Apollo data (e.g., [1], [2]), but there is scant information about the structure below the deepest moonquakes at about 1000 km depth. On the other hand, there have been geodetic studies to infer the deep structure of the Moon. For example, LLR (Lunar Laser Ranging) data analyses detected a displacement of the lunar pole of rotation, indicating that dissipation is acting on the rotation arising from a fluid core [3]. Bayesian inversion using geodetic data (such as mass, moments of inertia, tidal Love numbers k2 and h2, and quality factor Q) also suggests a fluid core and partial melt in the lower mantle region [4]. Further improvements in determining the second-degree gravity coefficients (which will lead to better estimates of moments of inertia) and the Love number k2 will help us to better constrain the lunar internal structure. Differential VLBI (Very Long Baseline Interferometry) technique, which was used in the Japanese lunar exploration mission SELENE (Sept. 2007 - June 2009), is expected to contribute to better determining the second-degree potential Love number k2 and low-degree gravity coefficients. SELENE will be followed by the future lunar mission SELENE-2 which will carry both a lander and an orbiter. We propose to put the SELENE-type radio sources on these spacecraft in order to accurately estimate k2 and the low-degree gravity coefficients. By using the same-beam VLBI tracking technique, these parameters will be retrieved through precision orbit determination of the orbiter with respect to the lander which serves as a reference. The VLBI mission with the radio sources is currently one of the mission candidates for SELENE-2. We have conducted a preliminary simulation study on the

  17. Current status of the EPOS WG4 - GNSS and Other Geodetic Data

    Science.gov (United States)

    Fernandes, Rui; Bastos, Luisa; Bruyninx, Carine; D'Agostino, Nicola; Dousa, Jan; Ganas, Athanassios; Lidberg, Martin; Nocquet, Jean-Mathieu

    2014-05-01

    WG4 - "EPOS Geodetic Data and Other Geodetic Data" is the Working Group of the EPOS project in charge of defining and preparing the integration of the existing Pan-European Geodetic Infrastructures that will support European Geosciences, which is the ultimate goal of the EPOS project. The WG4 is formed by representatives of the participating EPOS countries (23) but it is also open to the entire geodetic community. In fact, WG4 also already includes members from countries that formally are not integrating EPOS in this first step. The geodetic component of EPOS (WG4) is dealing essentially with Research Infrastructures focused on continuous operating GNSS (cGNSS) in the current phase. The option of concentrating the efforts on the presently most generalized geodetic tool supporting research on Solid Earth was decided in order to optimize the existing resources. Nevertheless, WG4 will continue to pursue the development of tools and methodologies that permit the access of the EPOS community to other geodetic information (e.g., gravimetry). Furthermore, although the focus is on Solid Earth applications, other research and technical applications (e.g., reference frames, meteorology, space weather) can also benefit from the efforts of WG4 EPOS towards the optimization of the geodetic resources in Europe. We will present and discuss the plans for the implementation of the thematic and core services (TCS) for geodetic data within EPOS and the related business plan. We will focus on strategies towards the implementation of the best solutions that will permit to the end-users, and in particular geo-scientists, to access the geodetic data, derived solutions, and associated metadata using transparent and uniform processes. Five pillars have been defined proposed for the TCS: Dissemination, Preservation, Monitoring, and Analysis of geodetic data plus the Support and Governance Infrastructure. Current proposals and remaining open questions will be discussed.

  18. Exploring deformation scenarios in Timanfaya volcanic area (Lanzarote, Canary Islands) from GNSS and ground based geodetic observations

    Science.gov (United States)

    Riccardi, U.; Arnoso, J.; Benavent, M.; Vélez, E.; Tammaro, U.; Montesinos, F. G.

    2018-05-01

    We report on a detailed geodetic continuous monitoring in Timanfaya volcanic area (TVA), where the most intense geothermal anomalies of Lanzarote Island are located. We analyze about three years of GNSS data collected on a small network of five permanent stations, one of which at TVA, deployed on the island, and nearly 20 years of tiltmeter and strainmeter records acquired at Los Camelleros site settled in the facilities of the Geodynamics Laboratory of Lanzarote within TVA. This study is intended to contribute to understanding the active tectonics on Lanzarote Island and its origin, mainly in TVA. After characterizing and filtering out the seasonal periodicities related to "non-tectonic" sources from the geodetic records, a tentative ground deformation field is reconstructed through the analysis of both tilt, strain records and the time evolution of the baselines ranging the GNSS stations. The joint interpretation of the collected geodetic data show that the area of the strongest geothermal anomaly in TVA is currently undergoing a SE trending relative displacement at a rate of about 3 mm/year. This area even experiences a significant subsidence with a maximum rate of about 6 mm/year. Moreover, we examine the possible relation between the observed deformations and atmospheric effects by modelling the response functions of temperature and rain recorded in the laboratory. Finally, from the retrieval of the deformation patterns and the joint analysis of geodetic and environmental observations, we propose a qualitative model of the interplaying role between the hydrological systems and the geothermal anomalies. Namely, we explain the detected time correlation between rainfall and ground deformation because of the enhancement of the thermal transfer from the underground heat source driven by the infiltration of meteoric water.

  19. Geodetic refraction effects of electromagnetic wave propagation through the atmosphere

    CERN Document Server

    1984-01-01

    With very few exceptions, geodetic measurements use electro­ magnetic radiation in order to measure directions, distances, time delays, and Doppler frequency shifts, to name the main ter­ restrial and space observables. Depending on the wavelength of the radiation and the purpose of the measurements, the follow­ ing parameters of the electromagnetic wave are measured: ampli­ tude, phase, angle-of-arrival, polarisation and frequency. Ac­ curate corrections have to be applied to the measurements in order to take into account the effects of the intervening medium between transmitter and receiver. The known solutions use at­ mospheric models, special observation programs, remote sensing techniques and instrumental methods. It has been shown that the effects of the earth's atmospheric envelope present a fundamental limitation to the accuracy and precision of geodetic measurements. This applies equally to ter­ restrial and space applications. Instrumental accuracies are al­ ready below the atmospherically i...

  20. Adjustment of positional geodetic networks by unconventional estimations

    Directory of Open Access Journals (Sweden)

    Silvia Gašincová

    2010-06-01

    Full Text Available The content of this paper is the adjustment of positional geodetic networks by robust estimations. The techniques (basedon the unconventional estimations of repeated least-square method which have turned out to be suitable and applicable in the practisehave been demonstrated on the example of the local geodetic network, which was founded to compose this thesis. In the thesisthe following techniques have been chosen to compare the Method of least-squares with those many published in foreign literature:M-estimation of Biweight,M-estimation of Welsch and Danish method. All presented methods are based on the repeated least-squaremethod principle with gradual changing of weight of individual measurements. In the first stage a standard least-square method wascarried out in the following steps – iterations we gradually change individual weights according to the relevant instructions/ regulation(so-called weight function. Iteration process will be stopped when no deviated measurements are found in the file of measured data.MatLab programme version 5.2 T was used to implement mathematical adjustment.

  1. Geodetic contributions to IWRM-projects in middle Java, Indonesia

    Science.gov (United States)

    Schmitt, Günter

    2010-12-01

    The district of Gunung Kidul in middle Java is one of the poorest regions in Indonesia. The essential reason is the acute water scarcity in this karst region during the months of the dry season. As a consequence of the poor living conditions many people have migrated away and therefore the development of the region is stagnating. During the last few years two projects have been initiated under the theme “Integrated Water Resources Management” in order to improve the water supply situation, both funded by the German Federal Ministry of Education and Research, and realized essentially by institutes of the University of Karlsruhe. Geodetic sub-projects are integrated into both projects. Special surveying activities had been, and have still to be, carried out to realise the geometrical basis for several other sub-projects. The particular contributions are 3D cave measurements for visualisation and planning, staking out of drilling points and construction axes, the definition of a common reference system, the surveying of the water distribution network and its technical facilities, the setting up and the management of a geographical information system (GIS), as well as special measurements such as dam monitoring or controlling of a vertical drilling machine. The paper reviews these projects and describes the geodetic activities.

  2. Geodetic Control Points, Benchmarks; Vertical elevation bench marks for monumented geodetic survey control points for which mean sea level elevations have been determined., Published in 1995, 1:24000 (1in=2000ft) scale, Rhode Island and Providence Plantations.

    Data.gov (United States)

    NSGIC State | GIS Inventory — Geodetic Control Points dataset current as of 1995. Benchmarks; Vertical elevation bench marks for monumented geodetic survey control points for which mean sea level...

  3. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.

    Science.gov (United States)

    Persky, Victoria; Piorkowski, Julie; Turyk, Mary; Freels, Sally; Chatterton, Robert; Dimos, John; Bradlow, H Leon; Chary, Lin Kaatz; Burse, Virlyn; Unterman, Terry; Sepkovic, Daniel W; McCann, Kenneth

    2012-08-29

    Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive associations of polychlorinated biphenyls (PCBs) and inverse associations of selected steroid hormones with diabetes in postmenopausal women previously employed in a capacitor manufacturing plant. This paper examines associations of PCBs with diabetes and endogenous hormones in 63 men previously employed at the same plant who in 1996 underwent surveys of their exposure and medical history and collection of bloods and urine for measurements of PCBs, lipids, liver function, hematologic markers and endogenous hormones. PCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake. History of diabetes was significantly related to total PCBs and all PCB functional groupings, but not to quarters worked and job score, after control for potential confounders. None of the exposures were related to insulin resistance (HOMA-IR) in non-diabetic men. Associations of PCBs with specific endogenous hormones differ in some respects from previous findings in postmenopausal women employed at the capacitor plant. Results from this study, however, do confirm previous reports relating PCB exposure to diabetes and suggest that these associations are not mediated by measured endogenous hormones.

  4. Evidences of Episodic Crustal Magmatic Diapir and Shallow Volcanic Activity at Uturuncu, Central Andes, from Geodetic Observations between 2014 - 2017

    Science.gov (United States)

    Lau, H. N.; Tymofyeyeva, E.; Fialko, Y. A.

    2017-12-01

    Previous space geodetic studies using ERS-1/2 and Envisat Interferometric Synthetic Aperture Radar (InSAR) data revealed a broad uplift of 10 mm/yr within the Altiplano-Puna Volcanic Complex (APVC), centered at the Uturuncu volcano, surrounded by a ring of subsidence at a rate of a few millimeters per year. This pattern was attributed to formation of a diapir in the middle of the Altiplano-Puna Magma Body (APMB), at depth of 15-19 km. We use new data from the Sentinel-1 InSAR mission, collected between 2014-2017, to produce high-resolution maps of surface displacements in the satellite's line of sight (LOS) from 4 satellite tracks. We estimated random propagation effects (e.g. due to atmospheric turbulence) using a common-point stacking method by Tymofyeyeva and Fialko [2015] and estimated temporally-correlated propagation effects (e.g. due to seasonal variations in atmospheric moisture) using a regression of the residual phase against topography. The estimated atmospheric artifacts were removed from the interferograms prior to computing the time series of the LOS displacements. The data indicate that the uplift above the APMB has considerably slowed down compared to the 1992-2010 epoch. The observed variations in the uplift rate suggest that the "ballooning" of the mid-crustal diapir is episodic on time scales of year to decades, possibly due to variations in melt supply from the partially molten APMB to the incipient diapir. We also find a previously undiscovered localized uplift 11 km south of Uturuncu's peak with maximum LOS velocities of 10 - 15 mm/yr. Joint inversions of data from different satellite tracks for a point source of inflation in an elastic half space constrain the source depth to be at 2 km, suggestive of a shallow magma chamber or a hydrothermal system.

  5. Quantifying the influence of previously burned areas on suppression effectiveness and avoided exposure: A case study of the Las Conchas Fire

    Science.gov (United States)

    Matthew P. Thompson; Patrick Freeborn; Jon D. Rieck; Dave Calkin; Julie W. Gilbertson-Day; Mark A. Cochrane; Michael S. Hand

    2016-01-01

    We present a case study of the Las Conchas Fire (2011) to explore the role of previously burned areas (wildfires and prescribed fires) on suppression effectiveness and avoided exposure. Methodological innovations include characterisation of the joint dynamics of fire growth and suppression activities, development of a fire line effectiveness framework, and...

  6. Study of some physical aspects previous to design of an exponential experiment; Estudio de algunos aspectos fisicos previos al diseno de una experiencia exponencial

    Energy Technology Data Exchange (ETDEWEB)

    Caro, R; Francisco, J L. de

    1961-07-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs.

  7. A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens.

    Science.gov (United States)

    Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Omari, Michael; Otu, Jacob; Gehre, Florian; de Jong, Bouke; Antonio, Martin

    2018-04-02

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana.

  8. Land water storage from space and the geodetic infrastructure

    Science.gov (United States)

    Cazenave, A.; Larson, K.; Wahr, J.

    2009-04-01

    In recent years, remote sensing techniques have been increasingly used to monitor components of the water balance of large river basins. By complementing scarce in situ observations and hydrological modelling, space observations have the potential to significantly improve our understanding of hydrological processes at work in river basins and their relationship with climate variability and socio-economic life. Among the remote sensing tools used in land hydrology, several originate from space geodesy and are integral parts of the Global Geodetic Observing System. For example, satellite altimetry is used for systematic monitoring of water levels of large rivers, lakes and floodplains. InSAR allows the detection of surface water change. GRACE-based space gravity offers for the first time the possibility of directly measuring the spatio-temporal variations of the vertically integrated water storage in large river basins. GRACE is also extremely useful for measuring changes in mass of the snow pack in boreal regions. Vertical motions of the ground induced by changes in water storage in aquifers can be measured by both GPS and InSAR. These techniques can also be used to investigate water loading effects. Recently GPS has been used to measure changes in surface soil moisture, which would be important for agriculture, weather prediction, and for calibrationg satellite missions such as SMOS and SMAP. These few examples show that space and ground geodetic infrastructures are increasingly important for hydrological sciences and applications. Future missions like SWOT (Surface Waters Ocean Topography; a wide swath interferometric altimetry mission) and GRACE 2 (space gravimetry mission based on new technology) will provide a new generation of hydrological products with improved precision and resolution.

  9. A Community-based Partnership for a Sustainable GNSS Geodetic Network

    Science.gov (United States)

    Dokka, R. K.

    2009-12-01

    Geodetic networks offer unparalleled opportunities to monitor and understand many of the rhythms of the Earth most vital to the sustainability of modern and future societies, i.e., crustal motions, sea-level, and the weather. For crustal deformation studies, the advantage is clear. Modern measurements allow us to document not only the permanent strains incurred over a seismic cycle, for example, but also the ephemeral strains that are critical for understanding the underlying physical mechanism. To be effective for science, however, geodetic networks must be properly designed, capitalized, and maintained over sufficient time intervals to fully capture the processes in action. Unfortunately, most networks lack interoperability and lack a business plan to ensure long term sustainability. The USA, for example, lacks a unified nation-wide GNSS network that can sustain its self over the coming years, decades, and century. Current federal priorities do not yet envision such a singular network. Publicly and privately funded regional networks exist, but tend to be parochial in scope, and optimized for a special user community, e.g., surveying, crustal motions, etc. Data sharing is common, but the lack of input at the beginning limits the functionality of the system for non-primary users. Funding for private networks depend heavily on the user demand, business cycle, and regulatory requirements. Agencies funding science networks offer no guarantee of sustained support. An alternative model (GULFNet) developed in Louisiana is meeting user needs, is sustainable, and is helping engineers, surveyors, and geologists become more spatially enabled. The common denominator among all participants is the view that accurate, precise, and timely geodetic data have tangible value for all segments of society. Although operated by a university (LSU), GULFNet is a community-based partnership between public and private sectors. GULFNet simultaneously achieves scientific goals by providing

  10. Is email a reliable means of contacting authors of previously published papers? A study of the Emergency Medicine Journal for 2001.

    Science.gov (United States)

    O'Leary, F

    2003-07-01

    To determine whether it is possible to contact authors of previously published papers via email. A cross sectional study of the Emergency Medicine Journal for 2001. 118 articles were included in the study. The response rate from those with valid email addresses was 73%. There was no statistical difference between the type of email address used and the address being invalid (p=0.392) or between the type of article and the likelihood of a reply (p=0.197). More responses were obtained from work addresses when compared with Hotmail addresses (86% v 57%, p=0.02). Email is a valid means of contacting authors of previously published articles, particularly within the emergency medicine specialty. A work based email address may be a more valid means of contact than a Hotmail address.

  11. Modeling and Analysis of Integrated Bathymetric and Geodetic Data for Inventory Surveys of Mining Water Reservoirs

    Directory of Open Access Journals (Sweden)

    Ochałek Agnieszka

    2018-01-01

    Full Text Available The significant part of the hydrography is bathymetry, which is the empirical part of it. Bathymetry is the study of underwater depth of waterways and reservoirs, and graphic presentation of measured data in form of bathymetric maps, cross-sections and three-dimensional bottom models. The bathymetric measurements are based on using Global Positioning System and devices for hydrographic measurements – an echo sounder and a side sonar scanner. In this research authors focused on introducing the case of obtaining and processing the bathymetrical data, building numerical bottom models of two post-mining reclaimed water reservoirs: Dwudniaki Lake in Wierzchosławice and flooded quarry in Zabierzów. The report includes also analysing data from still operating mining water reservoirs located in Poland to depict how bathymetry can be used in mining industry. The significant issue is an integration of bathymetrical data and geodetic data from tachymetry, terrestrial laser scanning measurements.

  12. Modeling and Analysis of Integrated Bathymetric and Geodetic Data for Inventory Surveys of Mining Water Reservoirs

    Science.gov (United States)

    Ochałek, Agnieszka; Lipecki, Tomasz; Jaśkowski, Wojciech; Jabłoński, Mateusz

    2018-03-01

    The significant part of the hydrography is bathymetry, which is the empirical part of it. Bathymetry is the study of underwater depth of waterways and reservoirs, and graphic presentation of measured data in form of bathymetric maps, cross-sections and three-dimensional bottom models. The bathymetric measurements are based on using Global Positioning System and devices for hydrographic measurements - an echo sounder and a side sonar scanner. In this research authors focused on introducing the case of obtaining and processing the bathymetrical data, building numerical bottom models of two post-mining reclaimed water reservoirs: Dwudniaki Lake in Wierzchosławice and flooded quarry in Zabierzów. The report includes also analysing data from still operating mining water reservoirs located in Poland to depict how bathymetry can be used in mining industry. The significant issue is an integration of bathymetrical data and geodetic data from tachymetry, terrestrial laser scanning measurements.

  13. Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.

    Science.gov (United States)

    Yamaguchi, Satoko; Waki, Kayo; Tomizawa, Nobuko; Waki, Hironori; Nannya, Yasuhito; Nangaku, Masaomi; Kadowaki, Takashi; Ohe, Kazuhiko

    2017-07-01

    Preventing dropout is crucial in managing diabetes. Accordingly, we investigated whether patients who had dropped out of diabetic care are suitable candidates for the use of mobile technologies - such as smartphone applications - to support self-management (mHealth), which might help prevent dropout. We carried out a cross-sectional study in Tokyo, Japan. Patients aged 20 years or older who were clinically diagnosed as diabetic and who regularly visited the outpatient unit at the University of Tokyo Hospital were recruited between August 2014 and March 2015. Data were collected through face-to-face structured interviews, physical measurements and medical records. Participants were asked whether they were willing to use mHealth after being shown DialBetics - an mHealth application for diabetics - as an example, and about their history of dropout and previous mHealth experience. Data were analyzed by multivariate logistic regression models. Of 307 patients with type 1 and type 2 diabetes, 34 (11.1%) had previously dropped out from diabetic care. Multivariate analysis identified previous mHealth experience as a negative predictor of dropout (odds ratio 0.211, P = 0.023). Of those 34 patients, 27 (79.4%) expressed willingness to use mHealth, a significantly higher percentage than for those who had never dropped out (51.5%, P = 0.002). After adjusting for confounders, history of dropout remained a strong predictor of willingness (odds ratio 3.870, P = 0.004). Patients who previously dropped out of diabetic care are suitable candidates for mHealth. Future studies must evaluate whether mHealth is effective for preventing repeated dropout and improving glycemic control among this population. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

  14. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study

    DEFF Research Database (Denmark)

    Schramm, Tina Ken; Gislason, Gunnar Hilmar; Vaag, Allan

    2011-01-01

    Aims The impact of insulin secretagogues (ISs) on long-term major clinical outcomes in type 2 diabetes remains unclear. We examined mortality and cardiovascular risk associated with all available ISs compared with metformin in a nationwide study. Methods and results All Danish residents >20 years......, initiating single-agent ISs or metformin between 1997 and 2006 were followed for up to 9 years (median 3.3 years) by individual-level linkage of nationwide registers. All-cause mortality, cardiovascular mortality, and the composite of myocardial infarction (MI), stroke, and cardiovascular mortality...... associated with individual ISs were investigated in patients with or without previous MI by multivariable Cox proportional-hazard analyses including propensity analyses. A total of 107 806 subjects were included, of whom 9607 had previous MI. Compared with metformin, glimepiride (hazard ratios and 95...

  15. Results from the Geodetic Observatory TIGO due to the Mw 8.8 Earthquake

    Science.gov (United States)

    Hase, H.; Böer, A.; Sierk, B.; Ihde, J.; Weber, G.; Wilmes, H.; Falk, R.; Hessels, U.; Neumaier, P.; Söhne, W.; Wziontek, H.; Engelhard, G.; Sobarzo, S.; Cifuentes, O.; Guaitiao, C.; Cona, I.; Avendaño, M.; Herrera, C.; Mora, V.; Fernandez, A.; Oñate, E.; Zaror, P.; Pedreros, F.; Zapata, O.

    2010-12-01

    The Geodetic Observatory TIGO is unique in Latin America. With its sensors and instruments it defines a reference point in the time, space and gravity field domain. Its operation started in 2002, for which reason data series documented the preseismic situation very well. With the Mw 8.8 earthquake on February 27, 2010, the entire observatory was exposed to strong motions due to its closeness to the epicenter. Since then the postseismic behaviour of the subduction zone can be studied and compared with the preseismic situation. TIGO provided continuous GPS/GLONASS data with 1s samples which give an insight to the mechanism of the decoupling of the Nazca and the South-American plate. The displacement of more than 3m had a duration of 30s at the beginning of the 147s duration of the earthquake. The displacement could be confirmed afterwards with VLBI and SLR methods. TIGO used its absolute gravity meter in an unusual way with weekly measurements on the same monument. These data show an irregularity during the last 3 weeks before the earthquake. Finally the postseismic movement to the west triggered by the earthquake and registered by geodetic space techniques indicate that the western expansion of the South-American plate did not stop yet. The pre- and post-seismic displacement vectors differ by less than 180° which might be explained by a fractional strike slip in the mega thrust. The coincidence of the epicenter with one of the keystations for global reference frames showed deficiencies by the linear modelling of tectonical movements in terrestial reference frames. This problem calls for near-real time reference frames.

  16. Acceleration and Orientation Jumping Performance Differences Among Elite Professional Male Handball Players With or Without Previous ACL Reconstruction: An Inertial Sensor Unit-Based Study.

    Science.gov (United States)

    Setuain, Igor; González-Izal, Miriam; Alfaro, Jesús; Gorostiaga, Esteban; Izquierdo, Mikel

    2015-12-01

    Handball is one of the most challenging sports for the knee joint. Persistent biomechanical and jumping capacity alterations can be observed in athletes with an anterior cruciate ligament (ACL) injury. Commonly identified jumping biomechanical alterations have been described by the use of laboratory technologies. However, portable and easy-to-handle technologies that enable an evaluation of jumping biomechanics at the training field are lacking. To analyze unilateral/bilateral acceleration and orientation jumping performance differences among elite male handball athletes with or without previous ACL reconstruction via a single inertial sensor unit device. Case control descriptive study. At the athletes' usual training court. Twenty-two elite male (6 ACL-reconstructed and 16 uninjured control players) handball players were evaluated. The participants performed a vertical jump test battery that included a 50-cm vertical bilateral drop jump, a 20-cm vertical unilateral drop jump, and vertical unilateral countermovement jump maneuvers. Peak 3-dimensional (X, Y, Z) acceleration (m·s(-2)), jump phase duration and 3-dimensional orientation values (°) were obtained from the inertial sensor unit device. Two-tailed t-tests and a one-way analysis of variance were performed to compare means. The P value cut-off for significance was set at P handball athletes with previous ACL reconstruction demonstrated a jumping biomechanical profile similar to control players, including similar jumping performance values in both bilateral and unilateral jumping maneuvers, several years after ACL reconstruction. These findings are in agreement with previous research showing full functional restoration of abilities in top-level male athletes after ACL reconstruction, rehabilitation and subsequent return to sports at the previous level. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  17. De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis

    Directory of Open Access Journals (Sweden)

    Amy Walker, B.S.

    2015-09-01

    Full Text Available Adamantinomatous craniopharyngiomas are histologically benign epithelial tumors which arise from embryonic remnants of the craniopharyngeal duct and Rathke’s pouch. They are thought to have a congenital origin and are histologically unique from papillary craniopharyngioma. We describe the case of an elderly male who presented with symptoms related to a large craniopharyngioma with previously normal brain magnetic resonance and computed tomography imaging studies. These findings dispute the embryogenic theory that craniopharyngiomas observed in adults develop from the persistent slow growth of embryonic remnants.

  18. Impact of Availability and Use of ART/PMTCT Services on Fertility Desires of Previously Pregnant Women in Rakai, Uganda: A Retrospective Cohort Study.

    Science.gov (United States)

    Litwin, Lindsay E; Makumbi, Frederick E; Gray, Ronald; Wawer, Maria; Kigozi, Godfrey; Kagaayi, Joseph; Nakigozi, Gertrude; Lutalo, Tom; Serwada, David; Brahmbhatt, Heena

    2015-07-01

    To assess fertility desires by availability and use of antiretroviral therapy and prevention of mother-to-child transmission (ART/PMTCT) services in Rakai, Uganda. Retrospective analyses of longitudinal data from the Rakai Community Cohort Study. Study participants were retrospectively identified and categorized by HIV status. Availability of ART/PMTCT services in Rakai was defined in three periods: (1) pre-ART/PMTCT (ART/PMTCT rollout (2005-2006), and (3) universal ART/PMTCT (>2006); and use of ART/PMTCT was coded as yes if the woman received services. Trends in fertility desires were assessed by χ. "Modified" Poisson regression was performed using generalized linear models with a log link and Poisson family to estimate prevalence rate ratios (PRRs) and 95% confidence intervals (CIs) of desire for another child among previously and currently pregnant women; PRRs were adjusted for demographic and behavioral factors. A total of 4227 sexually active women in Rakai, including 436 HIV+ women, contributed 13,970 observations over 5 survey rounds. Fertility desires increased in the population in the ART/PMTCT rollout [adjusted (adj.) PRR: 1.08, 95% CI: 1.04 to 1.13] and the universal availability periods (adj. PRR: 1.11, 95% CI: 1.08 to 1.14) compared with pre-ART/PMTCT period. A total of 862 woman observations used ART/PMTCT services. Fertility desires were similar among ART/PMTCT service users and nonusers in cross-sectional analysis (adj. PRR: 0.84, 95% CI: 0.62 to 1.14) and 1 year after ART/PMTCT use (adj. PRR: 1.27, 95% CI: 0.83 to 1.94). Availability of ART/PMTCT may increase fertility desires of previously pregnant women in Rakai, Uganda. Use of ART/PMTCT services was not correlated with fertility desires of previously or current pregnant women.

  19. Geodetic and geophysical observations in Antarctica an overview in the IPY perspective

    CERN Document Server

    Capra, Alessandro

    2008-01-01

    This book is a collection of papers on various aspects of the geodetic and geophysical investigation and observation techniques. It includes material from the Arctic and Antarctica, as well as covering work from both temporary and permanent observatories.

  20. On the effect of ionospheric delay on geodetic relative GPS positioning

    NARCIS (Netherlands)

    Georgiadou, P.Y.; Kleusberg, A.

    1988-01-01

    Uncorrected ionospheric delay is one of the factors limiting the accuracy in geodetic relative positioning with single frequency Global Positioning System (GPS) carrier phase observations. Dual frequency measurements can be combined to eliminate the ionospheric delay in the observations. A

  1. Outcome of secondary high-grade glioma in children previously treated for a malignant condition: A study of the Canadian Pediatric Brain Tumour Consortium

    International Nuclear Information System (INIS)

    Carret, Anne-Sophie; Tabori, Uri; Crooks, Bruce; Hukin, Juliette; Odame, Isaac; Johnston, Donna L.; Keene, Daniel L.; Freeman, Carolyn; Bouffet, Eric

    2006-01-01

    Background and purpose: Reports of secondary high-grade glioma (HGG) in survivors of childhood cancer are scarce. The aim of this study was to review the pattern of diagnosis, the treatment, and outcome of secondary pediatric HGG. Patients and methods: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC). Results: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n = 9) or solid tumour (n = 9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months. Conclusion: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours

  2. Three-dimensional stochastic adjustment of volcano geodetic network in Arenal volcano, Costa Rica

    Science.gov (United States)

    Muller, C.; van der Laat, R.; Cattin, P.-H.; Del Potro, R.

    2009-04-01

    Volcano geodetic networks are a key instrument to understanding magmatic processes and, thus, forecasting potentially hazardous activity. These networks are extensively used on volcanoes worldwide and generally comprise a number of different traditional and modern geodetic surveying techniques such as levelling, distances, triangulation and GNSS. However, in most cases, data from the different methodologies are surveyed, adjusted and analysed independently. Experience shows that the problem with this procedure is the mismatch between the excellent correlation of position values within a single technique and the low cross-correlation of such values within different techniques or when the same network is surveyed shortly after using the same technique. Moreover one different independent network for each geodetic surveying technique strongly increase logistics and thus the cost of each measurement campaign. It is therefore important to develop geodetic networks which combine the different geodetic surveying technique, and to adjust geodetic data together in order to better quantify the uncertainties associated to the measured displacements. In order to overcome the lack of inter-methodology data integration, the Geomatic Institute of the University of Applied Sciences of Western Switzerland (HEIG-VD) has developed a methodology which uses a 3D stochastic adjustment software of redundant geodetic networks, TRINET+. The methodology consists of using each geodetic measurement technique for its strengths relative to other methodologies. Also, the combination of the measurements in a single network allows more cost-effective surveying. The geodetic data are thereafter adjusted and analysed in the same referential frame. The adjustment methodology is based on the least mean square method and links the data with the geometry. Trinet+ also allows to run a priori simulations of the network, hence testing the quality and resolution to be expected for a determined network even

  3. Vitamin D deficiency in medical patients at a central hospital in Malawi: a comparison with TB patients from a previous study.

    Directory of Open Access Journals (Sweden)

    Yamikani Mastala

    Full Text Available OBJECTIVES: To determine the prevalence of vitamin D deficiency (VDD in adult medical, non-tuberculous (non-TB patients. To investigate associations with VDD. To compare the results with a similar study in TB patients at the same hospital. DESIGN: Cross-sectional sample. SETTING: Central hospital in Malawi. PARTICIPANTS: Adult non-TB patients (n = 157, inpatients and outpatients. OUTCOME MEASURES: The primary outcome was the prevalence of VDD. Potentially causal associations sought included nutritional status, in/outpatient status, HIV status, anti-retroviral therapy (ART and, by comparison with a previous study, a diagnosis of tuberculosis (TB. RESULTS: Hypovitaminosis D (≤75 nmol/L occurred in 47.8% (75/157 of patients, 16.6% (26/157 of whom had VDD (≤50 nmol/L. None had severe VDD (≤25 nmol/L. VDD was found in 22.8% (23/101 of in-patients and 5.4% (3/56 of out-patients. In univariable analysis in-patient status, ART use and low dietary vitamin D were significant predictors of VDD. VDD was less prevalent than in previously studied TB patients in the same hospital (68/161 = 42%. In multivariate analysis of the combined data set from both studies, having TB (OR 3.61, 95%CI 2.02-6.43 and being an in-patient (OR 2.70, 95%CI 1.46-5.01 were significant independent predictors of VDD. CONCLUSIONS: About half of adult medical patients without TB have suboptimal vitamin D status, which is more common in in-patients. VDD is much more common in TB patients than non-TB patients, even when other variables are controlled for, suggesting that vitamin D deficiency is associated with TB.

  4. Geodetic determinations for the NuMI project at Fermilab

    International Nuclear Information System (INIS)

    Bocean, V.

    1999-01-01

    As a part of the Neutrinos at the Main Injector (NuMI) project, the MINOS (Main Injector Neutrino Oscillation Search) experiment will search for neutrino mass by looking for neutrino oscillations. The project plans to direct a beam of muon neutrinos from the Main Injector towards both nearby and far-off detectors capable of counting all three types of neutrinos. The beam will travel 735 km through the Earth towards a remote iron mine in northern Minnesota where, 710 m below surface, a massive 5400 metric tons detector will be built. For the neutrino energy spectrum physics test to work properly, the primary proton beam must be within ± 12 m from its ideal position at Soudan, MN, corresponding to ± 1.63 x 10-5 radians, i.e. 3.4 arc-seconds. Achieving this tolerance requires a rather exact knowledge of the geometry of the beam, expressed in terms of the azimuth and the slope of the vector joining the two sites. This paper summarizes the concepts, the methodology, the implementation, and the results of the geodetic surveying efforts made up to date for determining the absolute positions of the Fermilab and the Soudan underground mine sites, from which the beam orientation parameters are computed. (author)

  5. Thin-plate spline quadrature of geodetic integrals

    Science.gov (United States)

    Vangysen, Herman

    1989-01-01

    Thin-plate spline functions (known for their flexibility and fidelity in representing experimental data) are especially well-suited for the numerical integration of geodetic integrals in the area where the integration is most sensitive to the data, i.e., in the immediate vicinity of the evaluation point. Spline quadrature rules are derived for the contribution of a circular innermost zone to Stoke's formula, to the formulae of Vening Meinesz, and to the recursively evaluated operator L(n) in the analytical continuation solution of Molodensky's problem. These rules are exact for interpolating thin-plate splines. In cases where the integration data are distributed irregularly, a system of linear equations needs to be solved for the quadrature coefficients. Formulae are given for the terms appearing in these equations. In case the data are regularly distributed, the coefficients may be determined once-and-for-all. Examples are given of some fixed-point rules. With such rules successive evaluation, within a circular disk, of the terms in Molodensky's series becomes relatively easy. The spline quadrature technique presented complements other techniques such as ring integration for intermediate integration zones.

  6. Azimuth selection for sea level measurements using geodetic GPS receivers

    Science.gov (United States)

    Wang, Xiaolei; Zhang, Qin; Zhang, Shuangcheng

    2018-03-01

    Based on analysis of Global Positioning System (GPS) multipath signals recorded by a geodetic GPS receiver, GPS Reflectometry (GPS-R) has demonstrated unique advantages in relation to sea level monitoring. Founded on multipath reflectometry theory, sea level changes can be measured by GPS-R through spectral analysis of recorded signal-to-noise ratio data. However, prior to estimating multipath parameters, it is necessary to define azimuth and elevation angle mask to ensure the reflecting zones are on water. Here, a method is presented to address azimuth selection, a topic currently under active development in the field of GPS-R. Data from three test sites: the Kachemak Bay GPS site PBAY in Alaska (USA), Friday Harbor GPS site SC02 in the San Juan Islands (USA), and Brest Harbor GPS site BRST in Brest (France) are analyzed. These sites are located in different multipath environments, from a rural coastal area to a busy harbor, and they experience different tidal ranges. Estimates by the GPS tide gauges at azimuths selected by the presented method are compared with measurements from physical tide gauges and acceptable correspondence found for all three sites.

  7. Plantar pressure in diabetic peripheral neuropathy patients with active foot ulceration, previous ulceration and no history of ulceration: a meta-analysis of observational studies.

    Science.gov (United States)

    Fernando, Malindu Eranga; Crowther, Robert George; Pappas, Elise; Lazzarini, Peter Anthony; Cunningham, Margaret; Sangla, Kunwarjit Singh; Buttner, Petra; Golledge, Jonathan

    2014-01-01

    Elevated dynamic plantar pressures are a consistent finding in diabetes patients with peripheral neuropathy with implications for plantar foot ulceration. This meta-analysis aimed to compare the plantar pressures of diabetes patients that had peripheral neuropathy and those with neuropathy with active or previous foot ulcers. Published articles were identified from Medline via OVID, CINAHL, SCOPUS, INFORMIT, Cochrane Central EMBASE via OVID and Web of Science via ISI Web of Knowledge bibliographic databases. Observational studies reporting barefoot dynamic plantar pressure in adults with diabetic peripheral neuropathy, where at least one group had a history of plantar foot ulcers were included. Interventional studies, shod plantar pressure studies and studies not published in English were excluded. Overall mean peak plantar pressure (MPP) and pressure time integral (PTI) were primary outcomes. The six secondary outcomes were MPP and PTI at the rear foot, mid foot and fore foot. The protocol of the meta-analysis was published with PROPSERO, (registration number CRD42013004310). Eight observational studies were included. Overall MPP and PTI were greater in diabetic peripheral neuropathy patients with foot ulceration compared to those without ulceration (standardised mean difference 0.551, 95% CI 0.290-0.811, pdiabetic peripheral neuropathy with a history of foot ulceration compared to those with diabetic neuropathy without a history of ulceration. More homogenous data is needed to confirm these findings.

  8. Monitoring deep geodynamic processes within Vrancea intermediate-depth seismic zone by geodetic means

    Science.gov (United States)

    Besutiu, Lucian; Zlagnean, Luminita

    2015-04-01

    Background Located in the bending zone of East Carpathians, the so-called Vrancea zone is one of the most active seismic regions in Europe. Despite many years of international research, its intermediate-depth seismicity within full intra-continental environment still represents a challenge of the 21st century. Infrastructure In the attempt to join the above-mentioned efforts, the Solid Earth Dynamics Department (SEDD) in the Institute of Geodynamics of the Romanian Academy has developed a special research infrastructure, mainly devoted to gravity and space geodesy observations. A geodetic network covering the epicentre area of the intermediate-depth earthquakes has been designed and implemented for monitoring deep geodynamic processes and their surface echoes. Within each base-station of the above-mentioned network, a still-reinforced concrete pillar allows for high accuracy repeated gravity and GPS determinations. Results Starting from some results of the previously run CERGOP and UNIGRACE European programmes, to which additional SEDD repeated field campaigns were added, an unusual geodynamic behaviour has been revealed in the area. 1) Crust deformation: unlike the overall uprising of East Carpathians, as a result of denudation followed by erosion, their SE bending zone, with Vrancea epicentre area exhibits a slight subsidence. 2) Gravity change: more than 200 microgals non-tidal gravity decrease over a 20 years time-span has been noticed within the subsiding area. Extended observations showed the gravity lowering as a nowadays continuing process. Interpretation This strange combination of topography subsidence and gravity lowering has been interpreted in terms of crust stretching in the Vrancea epicentre zone due to the gravity pull created by densification of the lower crust as a result of phase-transform processes taking place in the lithospheric compartment sunken into the upper mantle. The occurrence of crust earthquakes with vertical-extension focal

  9. Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease

    DEFF Research Database (Denmark)

    Sorensen, M.; Lassen, Ulrik Niels; Jensen, Peter Buhl

    2008-01-01

    INTRODUCTION: Treatment with a topoisomerase I inhibitor in combination with a platinum results in superior or equal survival compared with etoposide-based treatment in extensive disease small cell lung cancer (SCLC). Five-day topotecan is inconvenient and therefore shorter schedules of topotecan...... and cisplatin are needed. The aim of this phase II study was to establish the response rate and response duration in chemo-naive patients with SCLC receiving a 3-day topotecan and cisplatin schedule. METHODS: Simons optimal two-stage design was used. Patients with previously untreated extensive disease SCLC...... age was 59 (range 44-74), 79% had performance status 0 or 1. Thirty-one patients completed all six cycles. Grade 3/4 anemia, neutrocytopenia, and thrombocytopenia were recorded in 9.5%, 66.7%, and 21.4% of patients, respectively. Fourteen percent of patients experienced neutropenic fever. No episodes...

  10. EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

    Science.gov (United States)

    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen

    2015-12-01

    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity.

  11. Trial of labour and vaginal birth after previous caesarean section: A population based study of Eastern African immigrants in Victoria, Australia.

    Science.gov (United States)

    Belihu, Fetene B; Small, Rhonda; Davey, Mary-Ann

    2017-03-01

    Variations in caesarean section (CS) between some immigrant groups and receiving country populations have been widely reported. Often, African immigrant women are at higher risk of CS than the receiving population in developed countries. However, evidence about subsequent mode of birth following CS for African women post-migration is lacking. The objective of this study was to examine differences in attempted and successful vaginal birth after previous caesarean (VBAC) for Eastern African immigrants (Eritrea, Ethiopia, Somalia and Sudan) compared with Australian-born women. A population-based observational study was conducted using the Victorian Perinatal Data Collection. Pearson's chi-square test and logistic regression analysis were performed to generate adjusted odds ratios for attempted and successful VBAC. Victoria, Australia. 554 Eastern African immigrants and 24,587 Australian-born eligible women with previous CS having singleton births in public care. 41.5% of Eastern African immigrant women and 26.1% Australian-born women attempted a VBAC with 50.9% of Eastern African immigrants and 60.5% of Australian-born women being successful. After adjusting for maternal demographic characteristics and available clinical confounding factors, Eastern African immigrants were more likely to attempt (OR adj 1.94, 95% CI 1.57-2.47) but less likely to succeed (OR adj 0.54 95% CI 0.41-0.71) in having a VBAC. There are disparities in attempted and successful VBAC between Eastern African origin and Australian-born women. Unsuccessful VBAC attempt is more common among Eastern African immigrants, suggesting the need for improved strategies to select and support potential candidates for vaginal birth among these immigrants to enhance success and reduce potential complications associated with failed VBAC attempt. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  12. Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer

    International Nuclear Information System (INIS)

    Arcaroli, John; Quackenbush, Kevin; Dasari, Arvind; Powell, Rebecca; McManus, Martine; Tan, Aik-Choon; Foster, Nathan R; Picus, Joel; Wright, John; Nallapareddy, Sujatha; Erlichman, Charles; Hidalgo, Manuel; Messersmith, Wells A

    2012-01-01

    Src tyrosine kinases are overexpressed in pancreatic cancers, and the oral Src inhibitor saracatinib has shown antitumor activity in preclinical models of pancreas cancer. We performed a CTEP-sponsored Phase II clinical trial of saracatinib in previously treated pancreas cancer patients, with a primary endpoint of 6-month survival. A Simon MinMax two-stage phase II design was used. Saracatinib (175 mg/day) was administered orally continuously in 28-day cycles. In the unselected portion of the study, 18 patients were evaluable. Only two (11%) patients survived for at least 6 months, and three 6-month survivors were required to move to second stage of study as originally designed. The study was amended as a biomarker-driven trial (leucine rich repeat containing protein 19 [LRRC19] > insulin-like growth factor-binding protein 2 [IGFBP2] “top scoring pairs” polymerase chain reaction [PCR] assay, and PIK3CA mutant) based on preclinical data in a human pancreas tumor explant model. In the biomarker study, archival tumor tissue or fresh tumor biopsies were tested. Biomarker-positive patients were eligible for the study. Only one patient was PIK3CA mutant in a 3′ untranslated region (UTR) portion of the gene. This patient was enrolled in the study and failed to meet the 6-month survival endpoint. As the frequency of biomarker-positive patients was very low (<3%), the study was closed. Although we were unable to conclude whether enriching for a subset of second/third line pancreatic cancer patients treated with a Src inhibitor based on a biomarker would improve 6-month survival, we demonstrate that testing pancreatic tumor samples for a biomarker-driven, multicenter study in metastatic pancreas cancer is feasible

  13. Women's decision-making processes and the influences on their mode of birth following a previous caesarean section in Taiwan: a qualitative study.

    Science.gov (United States)

    Chen, Shu-Wen; Hutchinson, Alison M; Nagle, Cate; Bucknall, Tracey K

    2018-01-17

    Vaginal birth after caesarean (VBAC) is an alternative option for women who have had a previous caesarean section (CS); however, uptake is limited because of concern about the risks of uterine rupture. The aim of this study was to explore women's decision-making processes and the influences on their mode of birth following a previous CS. A qualitative approach was used. The research comprised three stages. Stage I consisted of naturalistic observation at 33-34 weeks' gestation. Stage II involved interviews with pregnant women at 35-37 weeks' gestation. Stage III consisted of interviews with the same women who were interviewed postnatally, 1 month after birth. The research was conducted in a private medical centre in northern Taiwan. Using a purposive sampling, 21 women and 9 obstetricians were recruited. Data collection involved in-depth interviews, observation and field notes. Constant comparative analysis was employed for data analysis. Ensuring the safety of mother and baby was the focus of women's decisions. Women's decisions-making influences included previous birth experience, concern about the risks of vaginal birth, evaluation of mode of birth, current pregnancy situation, information resources and health insurance. In communicating with obstetricians, some women complied with obstetricians' recommendations for repeat caesarean section (RCS) without being informed of alternatives. Others used four step decision-making processes that included searching for information, listening to obstetricians' professional judgement, evaluating alternatives, and making a decision regarding mode of birth. After birth, women reflected on their decisions in three aspects: reflection on birth choices; reflection on factors influencing decisions; and reflection on outcomes of decisions. The health and wellbeing of mother and baby were the major concerns for women. In response to the decision-making influences, women's interactions with obstetricians regarding birth choices

  14. GeoSEA: Geodetic Earthquake Observatory on the Seafloor

    Science.gov (United States)

    Kopp, Heidrun; Lange, Dietrich; Flueh, Ernst R.; Petersen, Florian; Behrmann, Jan-Hinrich; Devey, Colin

    2014-05-01

    Space geodetic observations of crustal deformation have contributed greatly to our understanding of plate tectonic processes in general, and plate subduction in particular. Measurements of interseismic strain have documented the active accumulation of strain, and subsequent strain release during earthquakes. However, techniques such as GPS cannot be applied below the water surface because the electromagnetic energy is strongly attenuated in the water column. Evidence suggests that much of the elastic strain build up and release (and particularly that responsible for both tsunami generation and giant earthquakes) occurs offshore. To quantify strain accumulation and assess the resultant hazard potential we urgently need systems to resolve seafloor crustal deformation. Here we report on first results of sea trials of a newly implemented seafloor geodesy array. The GeoSEA (Geodetic Earthquake Observatory on the Seafloor) array consists of a seafloor transponder network comprising 35 units and a wave glider acting as a surface unit (GeoSURF) to ensure satellite correspondence, data transfer and monitor system health. Seafloor displacement occurs in the horizontal (x,y) and vertical direction (z). The vertical displacement is measured by monitoring pressure variations at the seafloor. Horizontal seafloor displacement can be measured either using an acoustic/GPS combination to provide absolute positioning (requiring a suitably equipped vessel to perform repeated cruises to provide the GPS fixes) or by long-term acoustic telemetry between different beacons fixed on the seafloor to determine relative distances by using the travel time observations to each other, which is the technique tested during our short sea trials. For horizontal direct path measurements, the system utilizes acoustic ranging techniques with a ranging precision better than 15 mm and long term stability over 2 km distances. Vertical motion is obtained from pressure gauges. Integrated inclinometers

  15. Four Forensic Entomology Case Studies: Records and Behavioral Observations on Seldom Reported Cadaver Fauna With Notes on Relevant Previous Occurrences and Ecology.

    Science.gov (United States)

    Lindgren, Natalie K; Sisson, Melissa S; Archambeault, Alan D; Rahlwes, Brent C; Willett, James R; Bucheli, Sibyl R

    2015-03-01

    A yearlong survey of insect taxa associated with human decomposition was conducted at the Southeast Texas Applied Forensic Science (STAFS) facility located in the Center for Biological Field Studies of Sam Houston State University in Huntsville, TX. During this study, four insect-cadaver interactions were observed that represent previously poorly documented yet forensically significant interactions: Syrphidae maggots colonized a corpse in an aquatic situation; Psychodidae adults mated and oviposited on an algal film that was present on a corpse that had been recently removed from water; several Panorpidae were the first insects to feed upon a freshly placed corpse in the autumn; and a noctuid caterpillar was found chewing and ingesting dried human skin. Baseline knowledge of insect-cadaver interactions is the foundation of forensic entomology, and unique observations have the potential to expand our understanding of decomposition ecology. © The Author 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  16. Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised study

    International Nuclear Information System (INIS)

    Veronesi, Andrea; Miolo, GianMaria; Magri, Maria D; Crivellari, Diana; Scalone, Simona; Bidoli, Ettore; Lombardi, Davide

    2010-01-01

    A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients. From 1997 to 2003, patients aged 35 to 75 years, operated more than 2 years previously for monolateral breast cancer without adjuvant TAM, with no signs of metastases and no contraindication to TAM were randomized to TAM 20 mg/day orally for 2 years or follow-up alone. Events were categorized as locoregional relapse, distant metastases, metachronous breast cancer, tumours other than breast cancer and death from any causes, whichever occurred first. The sample size (197 patients per arm, plus 10% allowance) was based on the assumption of a 30% decrease in the number of events occurring at a rate of 5% annually in the 10 years following randomization. Four hundred and thirty-three patients were randomized in the study (TAM 217, follow-up 216). Patients characteristics (TAM/follow-up) included: median age 55/55 years, median time from surgery 25/25 months (range, 25-288/25-294), in situ carcinoma 18/24, oestrogen receptor (ER) positive in 75/68, negative in 70/57, unknown in 72/91 patients. Previous adjuvant treatment included chemotherapy in 131/120 and an LHRH analogue in 11/13 patients. Thirty-six patients prematurely discontinued TAM after a median of 1 month, mostly because of subjective intolerance. Eighty-three events (TAM 39, follow-up 44) occurred: locoregional relapse in 10/8, distant metastases in 14/16, metachronous breast cancer in 4/10, other tumours in 11/10 patients. Less ER-positive secondary breast cancers occurred in the TAM treated patients than in follow-up patients (1 vs 10, p = 0.005). Event-free survival was similar in both groups of patients. This 5-year analysis revealed significantly less metachronous ER-positive breast cancers in the TAM treated patients. No other statistically significant differences have emerged thus far

  17. Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Prevented Weight Regain in Obese Women with Polycystic Ovary Syndrome Previously Treated with Liraglutide: A Pilot Randomized Study.

    Science.gov (United States)

    Ferjan, Simona; Janez, Andrej; Jensterle, Mojca

    2017-12-01

    Weight loss is often nonsustainable after liraglutide cessation. The present study is the first insight into the potential prevention of weight regain in obese subjects who have been withdrawn from liraglutide. We evaluated whether dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in adjunct to metformin prevents body weight regain more effectively than metformin alone in obese polycystic ovary syndrome (PCOS) previously treated with liraglutide. A 12-week prospective randomized open-label study was conducted with 24 obese women with PCOS who had been pretreated with liraglutide 3.0 mg due to antiobesity management (aged 34.3 ± 6.8 years, body mass index [BMI] 36.3 ± 5.2 kg/m 2 , mean ± standard deviation). They were randomized to combined treatment (COMBO) with sitagliptin 100 mg per day (QD) and metformin (MET) 1000 mg twice daily (BID) (n = 12) or MET 1000 mg BID (n = 12). Lifestyle intervention was promoted in both groups. The primary outcome was change in anthropometric measures of obesity. Women treated with MET regain 4.7 ± 2.7 kg (P = 0.002) compared with a 0.9 ± 2.5 kg in COMBO (P = 0.147). BMI increased for 1.7 ± 0.9 kg/m 2 in MET (P = 0.002) compared with 0.3 ± 0.8 kg/m 2 increase in COMBO (P = 0.136). MET group regain 4.5% ± 2.5% of body weight as opposed to 0.8% ± 2.6% in COMBO. The between-treatment differences were significant for weight change (P weight change (P weight regain in obese women with PCOS previously treated with liraglutide.

  18. Feasibility of Construction of the Continuously Operating Geodetic GPS Network of Sinaloa, Mexico

    Science.gov (United States)

    Vazquez, G. E.; Jacobo, C.

    2011-12-01

    This research is based on the study and analysis of feasibility for the construction of the geodetic network for GPS continuous operation for Sinaloa, hereafter called (RGOCSIN). A GPS network of continuous operation is defined as that materialized structure physically through permanent monuments where measurements to the systems of Global Positioning (GPS) is performed continuously throughout a region. The GPS measurements in this network are measurements of accuracy according to international standards to define its coordinates, thus constituting the basic structure of geodetic referencing for a country. In this context is that in the near future the RGOCSIN constitutes a system state only accurate and reliable georeferencing in real-time (continuous and permanent operation) and will be used for different purposes; i.e., in addition to being fundamental basis for any lifting topographic or geodetic survey, and other areas such as: (1) Different construction processes (control and monitoring of engineering works); (2) Studies of deformation of the Earth's crust (before and after a seismic event); (3) GPS meteorology (weather forecasting); (4) Demarcation projects (natural and political); (5) Establishment of bases to generate mapping (necessary for the economic and social development of the state); (6) Precision agriculture (optimization of economic resources to the various crops); (7) Geographic information systems (Organization and planning activities associated with the design and construction of public services); (8) Urban growth (possible settlements in the appropriate form and taking care of the environmental aspect), among others. However there are criteria and regulations according to the INEGI (Instituto Nacional de Estadística y Geografía, http://www.inegi.org.mx/) that must be met; even for this stage of feasibility of construction that sees this project as a first phase. The fundamental criterion to be taken into account according to INEGI is a

  19. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    International Nuclear Information System (INIS)

    Rivero, Javier; Luzardo, Octavio P.; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-01-01

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  20. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Javier; Luzardo, Octavio P., E-mail: octavio.perez@ulpgc.es; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-12-15

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  1. Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies

    Directory of Open Access Journals (Sweden)

    Malahiyo Rajabu

    2010-06-01

    Full Text Available Abstract Background The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi. However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its reliability. Methods We assessed the performance of the Widal tube agglutination test among febrile hospitalized Tanzanian children. We calculated the sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV of various anti-TH and -TO titers using culture-confirmed typhoid fever cases as the "true positives" and all other febrile children with blood culture negative for S. typhi as the "true negatives." Results We found that 16 (1% of 1,680 children had culture-proven typhoid fever. A single anti-TH titer of 1:80 and higher was the optimal indicator of typhoid fever. This had a sensitivity of 75%, specificity of 98%, NPV of 100%, but PPV was only 26%. We compared our main findings with those from previous studies. Conclusion Among febrile hospitalized Tanzanian children with a low prevalence of typhoid fever, a Widal titer of ≥ 1:80 performed well in terms of sensitivity, specificity, and NPV. However a test with improved PPV that is similarly easy to apply and cost-efficient is desirable.

  2. Caring for women wanting a vaginal birth after previous caesarean section: A qualitative study of the experiences of midwives and obstetricians.

    Science.gov (United States)

    Foureur, Maralyn; Turkmani, Sabera; Clack, Danielle C; Davis, Deborah L; Mollart, Lyndall; Leiser, Bernadette; Homer, Caroline S E

    2017-02-01

    One of the greatest contributors to the overall caesarean section rate is elective repeat caesarean section. Decisions around mode of birth are often complex for women and influenced by the views of the doctors and midwives who care for and counsel women. Women may be more likely to choose a repeat elective caesarean section (CS) if their health care providers lack skills and confidence in supporting vaginal birth after caesarean section (VBAC). To explore the views and experiences of providers in caring for women considering VBAC, in particular the decision-making processes and the communication of risk and safety to women. A descriptive interpretive method was utilised. Four focus groups with doctors and midwives were conducted. The central themes were: 'developing trust', 'navigating the system' and 'optimising support'. The impact of past professional experiences; the critical importance of continuity of carer and positive relationships; the ability to weigh up risks versus benefits; and the language used were all important elements. The role of policy and guidelines on providing standardised care for women who had a previous CS was also highlighted. Midwives and doctors in this study were positively oriented towards assisting and supporting women to attempt a VBAC. Care providers considered that women who have experienced a prior CS need access to midwifery continuity of care with a focus on support, information-sharing and effective communication. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  3. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II, randomized, double-blind, placebo-controlled study

    International Nuclear Information System (INIS)

    Gregoire, Vincent; Hamoir, Marc; Chen Changhu; Kane, Madeleine; Kawecki, Andrzej; Julka, Pramod K.; Wang, Hung-Ming; Prasad, Srihari; D'Cruz, Anil K.; Radosevic-Jelic, Ljiljana; Kumar, Rejnish R.; Korzeniowski, Stanislaw; Fijuth, Jacek; Machiels, Jean-Pascal; Sellers, Mark V.; Tchakov, Ilian; Raben, David

    2011-01-01

    Background and purpose: To assess the efficacy and safety of gefitinib given concomitantly and/or as maintenance therapy to standard cisplatin/radiotherapy for previously untreated, unresected, stage III/IV non-metastatic SCCHN. Materials and methods: In this phase II, double-blind, study, 226 patients were randomized to gefitinib 250 mg/day, 500 mg/day or placebo in two phases: a concomitant phase (gefitinib or placebo with chemoradiotherapy), followed by a maintenance phase (gefitinib or placebo alone). Primary endpoint was local disease control rate (LDCR) at 2 years; secondary endpoints were LDCR at 1 year, objective response rate, progression-free survival, overall survival, and safety and tolerability. Results: Gefitinib (250 and 500 mg/day) did not improve 2-year LDCR compared with placebo either when given concomitantly with chemoradiotherapy (32.7% vs. 33.6%, respectively; OR 0.921, 95% CI 0.508, 1.670 [1-sided p = 0.607]) or as maintenance therapy (28.8% vs. 37.4%, respectively; OR 0.684, 95% CI 0.377, 1.241 [1-sided p = 0.894]). Secondary efficacy outcomes were broadly consistent with the 2-year LDCR results. In both doses, gefitinib was well-tolerated and did not adversely affect the safety and tolerability of concomitant chemoradiotherapy. Conclusion: Gefitinib was well-tolerated, but did not improve efficacy compared with placebo when given concomitantly with chemoradiotherapy, or as maintenance therapy alone.

  4. An Investigation on the Use of Different Centroiding Algorithms and Star Catalogs in Astro-Geodetic Observations

    Science.gov (United States)

    Basoglu, Burak; Halicioglu, Kerem; Albayrak, Muge; Ulug, Rasit; Tevfik Ozludemir, M.; Deniz, Rasim

    2017-04-01

    In the last decade, the importance of high-precise geoid determination at local or national level has been pointed out by Turkish National Geodesy Commission. The Commission has also put objective of modernization of national height system of Turkey to the agenda. Meanwhile several projects have been realized in recent years. In Istanbul city, a GNSS/Levelling geoid was defined in 2005 for the metropolitan area of the city with an accuracy of ±3.5cm. In order to achieve a better accuracy in this area, "Local Geoid Determination with Integration of GNSS/Levelling and Astro-Geodetic Data" project has been conducted in Istanbul Technical University and Bogazici University KOERI since January 2016. The project is funded by The Scientific and Technological Research Council of Turkey. With the scope of the project, modernization studies of Digital Zenith Camera System are being carried on in terms of hardware components and software development. Accentuated subjects are the star catalogues, and centroiding algorithm used to identify the stars on the zenithal star field. During the test observations of Digital Zenith Camera System performed between 2013-2016, final results were calculated using the PSF method for star centroiding, and the second USNO CCD Astrograph Catalogue (UCAC2) for the reference star positions. This study aims to investigate the position accuracy of the star images by comparing different centroiding algorithms and available star catalogs used in astro-geodetic observations conducted with the digital zenith camera system.

  5. Prevalence of pain in the head, back and feet in refugees previously exposed to torture: a ten-year follow-up study

    DEFF Research Database (Denmark)

    Olsen, Dorthe Reff; Montgomery, Edith; Bøjholm, Søren

    2007-01-01

    AIM: To estimate change over 10 years concerning the prevalence of pain in the head, back and feet, among previously tortured refugees settled in Denmark, and to compare associations between methods of torture and prevalent pain at baseline and at 10-year follow-up. METHODS: 139 refugees previous...... associated with the type and bodily focus of the torture. This presents a considerable challenge to future evidence-based development of effective treatment programs....

  6. Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru.

    Science.gov (United States)

    Lanata, Claudio F; Andrade, Teresa; Gil, Ana I; Terrones, Cynthia; Valladolid, Omar; Zambrano, Betzana; Saville, Melanie; Crevat, Denis

    2012-09-07

    In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a recombinant, live, attenuated, tetravalent dengue vaccine candidate (CYD-TDV) in 2-11 year-olds with varying levels of pre-existing yellow-fever immunity due to vaccination 1-7 years previously. 199 children received 3 injections of CYD-TDV (months 0, 6 and 12) and 99 received placebo (months 0 and 6) or pneumococcal polysaccharide vaccine (month 12). One month after the third dengue vaccination, serotype specific neutralizing antibody GMTs were in the range of 178-190 (1/dil) (versus 16.7-38.1 in the control group), a 10-20 fold-increase from baseline, and 94% of vaccines were seropositive to all four serotypes (versus 39% in the control group). There were no vaccine-related SAEs. The observed reactogenicity profile was consistent with phase I studies, with severity grade 1-2 injection site pain, headache, malaise and fever most frequently reported and no increase after subsequent vaccinations. Virologically confirmed dengue cases were seen after completion of the 3 doses: 1 in the CYD-TDV group (N=199), and 3 in the control group (N=99). A 3-dose regimen of CYD-TDV had a good safety profile in 2-11 year olds with a history of YF vaccination and elicited robust antibody responses that were balanced against the four serotypes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. A phase II study of VP-16-ifosfamide-cisplatin combination chemotherapy plus early concurrent thoracic irradiation for previously untreated limited small cell lung cancer

    International Nuclear Information System (INIS)

    Woo, In Sook; Park, Young Suk; Kwon, Sung Hee

    2000-01-01

    At present the addition of thoracic irradiation to combination chemotherapy is a standard treatment for limited staged small cell ling cancer. However, there is still controversy about the optimum timing of chest irradiation. We conducted a phase II study of etoposide (VP-16)-ifosfamide-cisplatin (VIP) combination chemotherapy plus early concurrent thoracic irradiation for the patients with previously untreated limited small cell lung cancer in order to assess if the treatment modality could improve the response rate and the toxicity. Forty-four patients with limited small cell lung cancer were treated with etoposide-ifosfamide-cisplatin and concurrent thoracic irradiation. Combination chemotherapy consisted of etoposide 100 mg/m 2 (on day 1-3), ifosfamide 1000 mg/m 2 (on days 1 and 2) and cisplatin 100 mg/m 2 (on day 1). Concurrent thoracic irradiation consisted of a total of 4000 cGy over 4 weeks starting on the first day of the first chemotherapy. All patients who showed a complete response were given prophylactic cranial irradiation for 2.5 weeks. Forty-four of the 49 patients who entered the study from May 1994 to August 1998 were evaluable. The median age was 59 years and 40 patients had a performance status of 0 or 1. The median survival time was 22.5 months. Twenty-eight patients (62%) showed a complete response and 16 (38%) a partial response. Twenty-four patients (54%) developed grade 3 or 4 neutropenia; there was a 9% RTOG score 3 or 4 esophagitis. VIP combination chemotherapy and early concurrent thoracic irradiation for patients with limited stage small cell lung cancer revealed excellent antitumor response with tolerable toxicity. (author)

  8. Operational production of Geodetic Excitation Functions from EOP estimated values at ASI-CGS

    Science.gov (United States)

    Sciarretta, C.; Luceri, V.; Bianco, G.

    2009-04-01

    ASI-CGS is routinely providing geodetic excitation functions from its own estimated EOP values (at present SLR and VLBI; the current use of GPS EOP's is also planned as soon as this product will be fully operational) on the ASI geodetic web site (http://geodaf.mt.asi.it). This product has been generated and monitored (for ASI internal use only) in a long pre-operational phase (more than two years), including validation and testing. The daily geodetic excitation functions are now weekly updated along with the operational ASI SLR and VLBI EOP solutions and compared, whenever possible, with the atmospheric excitation functions available at the IERS SBAAM, under the IB and not-IB assumption, including the "wind" term. The work will present the available estimated geodetic function time series and its comparison with the relevant atmospheric excitation functions, deriving quantitative indicators on the quality of the estimates. The similarities as well as the discrepancies among the atmospheric and geodetic series will be analysed and commented, evaluating in particular the degree of correlation among the two estimated time series and the likelihood of a linear dependence hypothesis.

  9. Displacement response of a concrete arch dam to seasonal temperature fluctuations and reservoir level rise during the first filling period: evidence from geodetic data

    Directory of Open Access Journals (Sweden)

    Cemal Ozer Yigit

    2016-07-01

    Full Text Available The present study evaluates the dynamic behaviour of the Ermenek Dam, the second highest dam in Turkey, based on conventional geodetic measurements and Finite Element Model (FEM analyses during its first filling period. In total, eight periods of measured deformation are considered from the end of construction until the reservoir reached its full capacity. The displacement response of the dam to the reservoir level and to seasonal temperature variations is examined in detail. Time series of apparent total displacements at the middle of the crest of the dam exhibits periodicity and linear trends. Correlation analysis revealed that periodic and linear displacement responses of the dam are related to variations of seasonal temperature and linearly increased reservoir level, respectively, indicating a relation between temperature, water load and dam deformation. It is also concluded that measured deformations based on geodetic data show good agreement with the predicted deformation obtained by the FEM analysis.

  10. Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.

    Science.gov (United States)

    Maréchaux, Sylvestre; Rusinaru, Dan; Jobic, Yannick; Ederhy, Stéphane; Donal, Erwan; Réant, Patricia; Arnalsteen, Elise; Boulanger, Jacques; Garban, Thierry; Ennezat, Pierre-Vladimir; Jeu, Antoine; Szymanski, Catherine; Tribouilloy, Christophe

    2015-02-01

    The Food and Drug Administration (FDA) criteria for diagnosis of drug-induced valvular heart disease (DIVHD) are only based on the observation of aortic regurgitation ≥ mild and/or mitral regurgitation ≥ moderate. We sought to evaluate the diagnostic value of FDA criteria in a cohort of control patients and in a cohort of patients exposed to a drug (benfluorex) known to induce VHD. This prospective, multicentre study included 376 diabetic control patients not exposed to valvulopathic drugs and 1000 subjects previously exposed to benfluorex. Diagnosis of mitral or aortic DIVHD was based on a combined functional and morphological echocardiographic analysis of cardiac valves. Patients were classified according to the FDA criteria [mitral or aortic-FDA(+) and mitral or aortic-FDA(-)]. Among the 376 control patients, 2 were wrongly classified as mitral-FDA(+) and 17 as aortic-FDA(+) (0.53 and 4.5% of false positives, respectively). Of those exposed to benfluorex, 48 of 58 with a diagnosis of mitral DIVHD (83%) were classified as mitral-FDA(-), and 901 of the 910 patients (99%) without a diagnosis of the mitral DIVHD group were classified as mitral-FDA(-). All 40 patients with a diagnosis of aortic DIVHD were classified as aortic-FDA(+), and 105 of the 910 patients without a diagnosis of aortic DIVHD (12%) were classified aortic-FDA(+). Older age and lower BMI were independent predictors of disagreement between FDA criteria and the diagnosis of DIVHD in patients exposed to benfluorex (both P ≤ 0.001). FDA criteria solely based on the Doppler detection of cardiac valve regurgitation underestimate for the mitral valve and overestimate for the aortic valve the frequency of DIVHD. Therefore, the diagnosis of DIVHD must be based on a combined echocardiographic and Doppler morphological and functional analysis of cardiac valves. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  11. SAFETY AND ACTIVITY OF TEMSIROLIMUS AND BEVACIZUMAB IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA PREVIOUSLY TREATED WITH TYROSINE KINASE INHIBITORS: A PHASE 2 CONSORTIUM STUDY

    Science.gov (United States)

    Merchan, Jaime R.; Qin, Rui; Pitot, Henry; Picus, Joel; Liu, Glenn; Fitch, Tom; Maples, William J.; Flynn, Patrick J.; Fruth, Briant F.; Erlichman, Charles

    2015-01-01

    Purpose Bevacizumab or Temsirolimus regimens have clinical activity in the first line treatment of advanced renal cell carcinoma (RCC). This phase I/II trial was conducted to determine the safety of combining both agents and its efficacy in RCC patients who progressed on at least one prior anti-VEGF receptor tyrosine kinase inhibitor (RTKI) agent. Methods In the phase I portion, eligible patients were treated with Temsirolimus (25 mg IV weekly) and escalating doses of IV Bevacizumab (level 1=5mg/kg; level 2=10 mg/kg) every other week. The primary endpoint for the phase II portion (RTKI resistant patients) was the 6-month progression free rate. Secondary endpoints were response rate, toxicity evaluation, PFS and OS. Results MTD was not reached at the maximum dose administered in 12 phase I patients. Forty evaluable patients were treated with the phase II recommended dose (Temsirolimus 25 mg IV weekly and Bevacizumab 10 mg/kg IV every two weeks). The 6-month progression free rate was 40% (16/40 pts). Median PFS was 5.9 (4-7.8) months, and median OS was 20.6 (11.5-23.7) months. Partial response/stable/progressive disease were seen in 23%/63%/14% of patients. Most common grade 3-4 AEs included fatigue (17.8%), hypertriglyceridemia (11.1%), stomatitis (8.9%), proteinuria (8.9%), abdominal pain (6.7%), and anemia (6.7%). Baseline levels of serum sFLT-1 and VEGF-A were inversely correlated with PFS and OS, respectively. Conclusions Temsirolimus and Bevacizumab is a feasible combination in patients with advanced RCC previously exposed to oral anti-VEGF agents. The safety and efficacy results warrant further confirmatory studies in this patient population. PMID:25556030

  12. Low-calorie energy drink improves physiological response to exercise in previously sedentary men: a placebo-controlled efficacy and safety study.

    Science.gov (United States)

    Lockwood, Christopher M; Moon, Jordan R; Smith, Abbie E; Tobkin, Sarah E; Kendall, Kristina L; Graef, Jennifer L; Cramer, Joel T; Stout, Jeffrey R

    2010-08-01

    Energy drink use has grown despite limited research to support efficacy or safety and amid concerns when combined with exercise. The purpose of this study was to assess the effects of 10 weeks of once-daily energy drink consumption or energy drink consumption with exercise on measures of body composition, cardiorespiratory fitness, strength, mood, and safety in previously sedentary males. Thirty-eight males were randomly assigned to energy drink + exercise (EX-A), energy drink (NEX-A), placebo + exercise (EX-B), or placebo (NEX-B). All participants consumed 1 drink per day for 10 weeks; EX-A and EX-B participated in 10 weeks of resistance and endurance exercise. Testing was performed before (PRE) and after (POST) the 10-week intervention. No significant (p > 0.05) changes were observed for body composition, fitness, or strength in NEX-A; however, significantly greater decreases in fat mass and percentage body fat and increases in VO2peak were observed in EX-A versus EX-B. Ventilatory threshold (VT), minute ventilation, VO2 at VT, and power output at VT improved significantly PRE to POST in EX-A but not in EX-B or nonexercising groups. Clinical markers for hepatic, renal, cardiovascular, and immune function, as determined by PRE and POST blood work revealed no adverse effects in response to the energy drink. Mood was not affected by energy drink use. Absent energy restriction or other dietary controls, chronic ingestion of a once-daily low-calorie energy drink appears ineffective at improving body composition, cardiorespiratory fitness, or strength in sedentary males. However, when combined with exercise, preworkout energy drink consumption may significantly improve some physiological adaptations to combined aerobic and resistance training.

  13. Phase I/II study of gefitinib (Iressa(®)) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer.

    Science.gov (United States)

    Han, Ji-Youn; Lee, Soo Hyun; Lee, Geon Kook; Yun, Tak; Lee, Young Joo; Hwang, Kum Hui; Kim, Jin Young; Kim, Heung Tae

    2015-03-01

    Vorinostat has been shown to overcome resistance to gefitinib. We performed a phase I/II study combining gefitinib with vorinostat in previously treated non-small cell lung cancer (NSCLC). A 3 + 3 dose-escalation design was used to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Three dose levels were tested: 250 mg/day gefitinib on days 1-28 and 200, 300 or 400 mg/day vorinostat on days 1-7, and 15-21 out of every 28 days. The primary endpoint was median progression-free survival (PFS). Fifty-two patients were enrolled and treated (43 in phase II). The median age was 59 years, 28 patients were male, 44 had adenocarcinoma, 29 had never smoked, and 36 had undergone one prior treatment. Twenty-two patients exhibited sensitive EGFR mutations. Planned dose escalation was completed without reaching the MTD. The RP2D was 250 mg gefitinib and 400 mg vorinostat. In 43 assessable patients in phase II, the median PFS was 3.2 months; the overall survival (OS) was 19.0 months. There were 16 partial responses and six cases of stable disease. In EGFR-mutant NSCLC, response rate was 77 %, median PFS was 9.1 months, and median OS was 24.1 months. The most common adverse events were anorexia and diarrhea. Treatment with 250 mg gefitinib daily with biweekly 400 mg/day vorinostat was feasible and well tolerated. In an unselected patient population, this combination dose did not improve PFS. However, this combination showed a potential for improving efficacy of gefitinib in EGFR-mutant NSCLC (NCT01027676).

  14. Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.

    Science.gov (United States)

    Klinger, Tatjana; Ibach, Bernd; Schoenknecht, Peter; Kamleiter, Martin; Silver, Gabrielle; Schroeder, Johannes; Mielke, Ruediger

    2005-05-01

    This open-label, prospective, observational, Post-Marketing Surveillance (PMS) study assessed the efficacy and safety of donepezil in patients who had been switched from therapies currently used in Germany to treat Alzheimer's disease (AD), such as memantine and nootropics, due to insufficient efficacy or poor tolerability. A treatment-naive population was included as a comparator. Patients with AD were treated with donepezil and observed for a period of approximately 3 months. A cognitive assessment was made using the Mini-Mental State Examination (MMSE). Quality of life (QoL) was assessed by the investigators who answered the question 'How did therapy with donepezil influence the QoL of the patient and/or his family over the observation period?' and was graded using three ratings: improved/unchanged/worsened. Adverse events (AEs) were also monitored. A total of 913 patients entered the study (mean +/- SD MMSE score 18.03 +/- 5.34). Efficacy assessments were analyzed for three groups: an overall group of patients who had received any form of prior AD drug therapy (N+ group; n = 709); a subgroup of patients from the N+ group who had received prior memantine therapy only (M+ group; n = 111) and patients who were drug treatment naive (N- group; n = 204). In the evaluable population donepezil improved MMSE scores by 2.21 +/- 3.47 points on average, with similar improvements observed in all three groups. QoL was judged to be improved in at least 70% of patients, again with similar results obtained for all three groups. Donepezil was well tolerated, with 85 of 913 (9.3%) patients reporting AEs. The most common AEs were those typically seen with cholinergic therapies (i.e., diarrhoea, vomiting and nausea). In this observational PMS study, donepezil was shown to be efficacious and well tolerated in patients who were being insufficiently treated with memantine or nootropic therapy. The magnitude of response was similar to that observed in patients who were previously

  15. Evidences of the expanding Earth from space-geodetic data over solid land and sea level rise in recent two decades

    Directory of Open Access Journals (Sweden)

    Wenbin Shen

    2015-07-01

    Full Text Available According to the space-geodetic data recorded at globally distributed stations over solid land spanning a period of more than 20-years under the International Terrestrial Reference Frame 2008, our previous estimate of the average-weighted vertical variation of the Earth's solid surface suggests that the Earth's solid part is expanding at a rate of 0.24 ± 0.05 mm/a in recent two decades. In another aspect, the satellite altimetry observations spanning recent two decades demonstrate the sea level rise (SLR rate 3.2 ± 0.4 mm/a, of which 1.8 ± 0.5 mm/a is contributed by the ice melting over land. This study shows that the oceanic thermal expansion is 1.0 ± 0.1 mm/a due to the temperature increase in recent half century, which coincides with the estimate provided by previous authors. The SLR observation by altimetry is not balanced by the ice melting and thermal expansion, which is an open problem before this study. However, in this study we infer that the oceanic part of the Earth is expanding at a rate about 0.4 mm/a. Combining the expansion rates of land part and oceanic part, we conclude that the Earth is expanding at a rate of 0.35 ± 0.47 mm/a in recent two decades. If the Earth expands at this rate, then the altimetry-observed SLR can be well explained.

  16. Geodetic constraints on continental rifting along the Red Sea

    Science.gov (United States)

    Reilinger, R.; McClusky, S.; Arrajehi, A.; Mahmoud, S.; Rayan, A.; Ghebreab, W.; Ogubazghi, G.; Al-Aydrus, A.

    2006-12-01

    We are using the Global Positioning System (GPS) to monitor and quantify patterns and rates of tectonic and magmatic deformation associated with active rifting of the continental lithosphere and the transition to sea floor spreading in the Red Sea. Broad-scale motions of the Nubian and Arabian plates indicate coherent plate motion with internal deformation below the current resolution of our measurements (~ 1-2 mm/yr). The GPS-determined Euler vector for Arabia-Nubia is indistinguishable from the geologic Euler vector determined from marine magnetic anomalies, and Arabia-Eurasia relative motion from GPS is equal within uncertainties to relative motion determined from plate reconstructions, suggesting that Arabia plate motion has remained constant (±10%) during at least the past ~10 Ma. The approximate agreement between broad-scale GPS rates of extension (i.e., determined from relative plate motions) and those determined from magnetic anomalies along the Red Sea rift implies that spreading in the central Red Sea is primarily confined to the central rift (±10-20%). Extension appears to be more broadly distributed in the N Red Sea and Gulf of Suez where comparisons with geologic data also indicate a relatively recent (between 500 and 125 kyr BP) change in the motion of the Sinai block that is distinct from both Nubia and Arabia. In the southern Red Sea, GPS results are beginning to define the motion of the "Danakil micro-plate". We investigate and report on a model involving CCW rotation of the Danakil micro-plate relative to Nubia and magmatic inflation below the Afar Triple Junction that is consistent with available geodetic constraints. Running the model back in time suggests that the Danakil micro-plate has been an integral part of rifting/triple junction processes throughout the history of separation of the Arabian and Nubian plates. On the scale of Nubia-Arabia-Eurasia plate interactions, we show that new area formed at spreading centers roughly equals that

  17. Geodetic infrastructure at the Barcelona harbour for sea level monitoring

    Science.gov (United States)

    Martinez-Benjamin, Juan Jose; Gili, Josep; Lopez, Rogelio; Tapia, Ana; Pros, Francesc; Palau, Vicenc; Perez, Begona

    2015-04-01

    The presentation is directed to the description of the actual geodetic infrastructure of Barcelona harbour with three tide gauges of different technologies for sea level determination and contribution to regional sea level rise and understanding past and present sea level rise in the Barcelona harbour. It is intended that the overall system will constitute a CGPS Station of the ESEAS (European Sea Level) and TIGA (GPS Tide Gauge Benchmark Monitoring) networks. At Barcelona harbour there is a MIROS radar tide gauge belonging to Puertos del Estado (Spanish Harbours).The radar sensor is over the water surface, on a L-shaped structure which elevates it a few meters above the quay shelf. 1-min data are transmitted to the ENAGAS Control Center by cable and then sent each 1 min to Puertos del Estado by e-mail. The information includes wave forescast (mean period, significant wave height, sea level, etc.This sensor also measures agitation and sends wave parameters each 20 min. There is a GPS station Leica Geosystems GRX1200 GG Pro and antenna AX 1202 GG. The Control Tower of the Port of Barcelona is situated in the North dike of the so-called Energy Pier in the Barcelona harbor (Spain). This tower has different kind of antennas for navigation monitoring and a GNSS permanent station. As the tower is founded in reclaimed land, and because its metallic structure, the 50 m building is subjected to diverse movements, including periodic fluctuations due to temperature changes. In this contribution the 2009, 2011, 2012, 2013 and 2014 the necessary monitoring campaigns are described. In the framework of a Spanish Space Project, the instrumentation of sea level measurements has been improved by providing the Barcelona site with a radar tide gauge Datamar 2000C from Geonica S.L. in June 2014 near an acoustic tide gauge from the Barcelona Harbour installed in 2013. Precision levelling has been made several times in the last two years because the tower is founded in reclaimed land and

  18. The Earth isn't flat: The (large) influence of topography on geodetic fault slip imaging.

    Science.gov (United States)

    Thompson, T. B.; Meade, B. J.

    2017-12-01

    While earthquakes both occur near and generate steep topography, most geodetic slip inversions assume that the Earth's surface is flat. We have developed a new boundary element tool, Tectosaur, with the capability to study fault and earthquake problems including complex fault system geometries, topography, material property contrasts, and millions of elements. Using Tectosaur, we study the model error induced by neglecting topography in both idealized synthetic fault models and for the cases of the MW=7.3 Landers and MW=8.0 Wenchuan earthquakes. Near the steepest topography, we find the use of flat Earth dislocation models may induce errors of more than 100% in the inferred slip magnitude and rake. In particular, neglecting topographic effects leads to an inferred shallow slip deficit. Thus, we propose that the shallow slip deficit observed in several earthquakes may be an artefact resulting from the systematic use of elastic dislocation models assuming a flat Earth. Finally, using this study as an example, we emphasize the dangerous potential for forward model errors to be amplified by an order of magnitude in inverse problems.

  19. Co-location of space geodetic techniques carried out at the Geodetic Observatory Wettzell using a closure in time and a multi-technique reference target

    Science.gov (United States)

    Kodet, J.; Schreiber, K. U.; Eckl, J.; Plötz, C.; Mähler, S.; Schüler, T.; Klügel, T.; Riepl, S.

    2018-01-01

    The quality of the links between the different space geodetic techniques (VLBI, SLR, GNSS and DORIS) is still one of the major limiting factors for the realization of a unique global terrestrial reference frame that is accurate enough to allow the monitoring of the Earth system, i.e., of processes like sea level change, postglacial rebound and silent earthquakes. According to the specifications of the global geodetic observing system of the International Association of Geodesy, such a reference frame should be accurate to 1 mm over decades, with rates of change stable at the level of 0.1 mm/year. The deficiencies arise from inaccurate or incomplete local ties at many fundamental sites as well as from systematic instrumental biases in the individual space geodetic techniques. Frequently repeated surveys, the continuous monitoring of antenna heights and the geometrical mount stability (Lösler et al. in J Geod 90:467-486, 2016. https://doi.org/10.1007/s00190-016-0887-8) have not provided evidence for insufficient antenna stability. Therefore, we have investigated variations in the respective system delays caused by electronic circuits, which is not adequately captured by the calibration process, either because of subtle differences in the circuitry between geodetic measurement and calibration, high temporal variability or because of lacking resolving bandwidth. The measured system delay variations in the electric chain of both VLBI- and SLR systems reach the order of 100 ps, which is equivalent to 3 cm of path length. Most of this variability is usually removed by the calibrations but by far not all. This paper focuses on the development of new technologies and procedures for co-located geodetic instrumentation in order to identify and remove systematic measurement biases within and between the individual measurement techniques. A closed-loop optical time and frequency distribution system and a common inter-technique reference target provide the possibility to remove

  20. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer (NMSC): A population-based study.

    Science.gov (United States)

    Fischer, Alexander H; Wang, Timothy S; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L

    2016-08-01

    Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit ultraviolet exposure. We sought to determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (CI), taking into account the complex survey design. Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% vs 27.0%; aPOR 1.41; 95% CI 1.16-1.71), long sleeves (20.5% vs 7.7%; aPOR 1.55; 95% CI 1.21-1.98), a wide-brimmed hat (26.1% vs 10.5%; aPOR 1.52; 95% CI 1.24-1.87), and sunscreen (53.7% vs 33.1%; aPOR 2.11; 95% CI 1.73-2.59), but did not have significantly lower odds of recent sunburn (29.7% vs 40.7%; aPOR 0.95; 95% CI 0.77-1.17). Among those with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Self-reported cross-sectional data and unavailable information quantifying regular sun exposure are limitations. Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  1. Uvođenje novih geodetskih referentnih sistema u Bosni i Hercegovini : Introduction of a new geodetic reference systems in Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Šeho Zimić

    2017-12-01

    Full Text Available The introduction of a new reference system in Bosnia and Herzegovina is not only a necessity, but an obligation imposed by the United Nations (UN and the European Union (EU. At the General Assembly on February 26, 2015, the UN has adopted a resolution titled "Global Geodetic Reference Frame for Sustainable Development - GGRF", which for the first time raise the geodetic issue as a political issue at such a high level. The resolution highlights the strong need for more precise positioning and navigation from the use of smartphones to the study of climate changes, population migrations and other scientific researches of relevance to the whole world (http://www.unggrf.org/. All this is not possible without a global exchange of geodata and a common global geodetic reference system. Through the Inspire Directive, the EU has clearly specified which coordinate and heights systems are being applied in Europe. The countries in the region have adopted the European terrestrial reference system ETRS89 as a new reference system in their legislation. Through the EUREF campaign BALKAN98 and the introduction of the Network of permanent GNSS stations Bosnia and Herzegovina has joined the famil

  2. Geodetic proof of vertical recent movements at the seism generating zone of Acambay, Mexico

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    Luis Miguel Espinosa-Rodríguez

    2016-12-01

    Full Text Available The central territorial belt oriented west-east and located along the parallel 19 in the Mexican Republic, is composed of a complex system of faults, that respond to the consequent morphology of a tension arched system, which has been erected to the Volcanic Transmexican or Transversal Belt. This region evidences the dynamics and evolution of a graben and horst tectonic system, as well as volcanic manifestations characterized by stratovolcanoes, monogenetic fields and fisural flows, among others. In particular, in the center of the Mexican regional complex, the fault system which delimits the region of Acambay in the state of Mexico, had showed evidences of seismogenerating activity during a century until the present time. According to the above and based on the geomorphological analysis and the geodetic measurements, the dynamic presented by these morphostructures in a multitemporal comparative study (1998/2003 o 2011 is showed. The rates of vertical tectonic movements reflect recent rise values ranging from + 7,3 to 12,8 mm/year in the northern horst of Santa María Tixmadejé, while in the central graben of Acambay are very weak, of the order of + 0,4 to + 0,5 mm/year.

  3. Application of median-equation approach for outlier detection in geodetic networks

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    Serif Hekimoglu

    Full Text Available In geodetic measurements some outliers may occur sometimes in data sets, depending on different reasons. There are two main approaches to detect outliers as Tests for outliers (Baarda's and Pope's Tests and robust methods (Danish method, Huber method etc.. These methods use the Least Squares Estimation (LSE. The outliers affect the LSE results, especially it smears the effects of the outliers on the good observations and sometimes wrong results may be obtained. To avoid these effects, a method that does not use LSE should be preferred. The median is a high breakdown point estimator and if it is applied for the outlier detection, reliable results can be obtained. In this study, a robust method which uses median with or as a treshould value on median residuals that are obtained from median equations is proposed. If the a priori variance of the observations is known, the reliability of the new approch is greater than the one in the case where the a priori variance is unknown.

  4. The crustal velocity field mosaic of the Alpine Mediterranean area (Italy): Insights from new geodetic data

    Science.gov (United States)

    Farolfi, Gregorio; Del Ventisette, Chiara

    2016-04-01

    A new horizontal crustal velocity field of Alpine Mediterranean area was determined by continuous long time series (6.5 years) of 113 Global Navigation Satellite System (GNSS) permanent stations. The processing was performed using state-of-the-art absolute antenna phase center correction model and recomputed precise IGS orbits available since April 2014. Moreover, a new more accurate tropospheric mapping function for geodetic applications was adopted. Results provide a new detailed map of the kinematics throughout the entire study area. This area is characterized by a complex tectonic setting driven by the interaction of Eurasian and African plates. The eastern Alps, Corsica, Sardinia and the Tyrrhenian Sea (which is covered only by interpolation data) show small velocity residuals with respect to the Eurasian plate. The whole Apennines axis discriminates two different velocity patterns, the Adriatic and the Tyrrhenian area. The area around Messina Strait, which separates peninsular Italy and Sicily, represents a poorly understood region. Results identify an important boundary zone between two different domains, Calabria and Sicily, which are characterized by different crustal motions. The northeastern part of Sicily and Calabria move like Adriatic area, whilst the rest of Sicily, Malta and Lampedusa are dominated by African motion.

  5. A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control.

    Directory of Open Access Journals (Sweden)

    Rosanna Ghinai

    2015-01-01

    Full Text Available Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5-17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.

  6. Geodetic antenna calibration test in the Antarctic environment

    Science.gov (United States)

    Grejner-Brzezinska, A.; Vazquez, E.; Hothem, L.

    2006-01-01

    TransAntarctic Mountain DEFormation (TAMDEF) Monitoring Network is the NSF-sponsored OSU and USGS project, aimed at measuring crustal motion in the Transantarctic Mountains of Victoria Land using GPS carrier phase measurements. Station monumentation, antenna mounts, antenna types, and data processing strategies were optimized to achieve mm-level estimates for the rates of motion. These data contributes also to regional Antarctic frame definition. Significant amount of data collected over several years allow the investigation of unique aspects of GPS geodesy in Antarctica, to determine how the error spectrum compares to the mid-latitude regions, and to identify the optimum measurement and data processing schemes for Antarctic conditions, in order to test the predicted rates of motion (mm-level w.r.t. time). The data collection for the TAMDEF project was initiated in 1996. The primary antenna used has been the Ashtech L1/L2 Dorne Margolin (D/M) choke ring. A few occupations involved the use of a Trimble D/M choke ring. The data were processed using the antenna calibration data available from the National Geodetic Survey (NGS). The recent developments in new antenna designs that are lighter in weight and lower in cost are being considered as a possible alternative to the bulkier and more expensive D/M choke ring design. In November 2003, in situ testing of three alternative models of L1/L2 antennas was conducted at a site located in the vicinity of McMurdo Station, Antarctica (S77.87, E166.56). The antenna models used in this test were: Ashtech D/M choke ring, Trimble D/M choke ring, Trimble Zephyr, and the NovAtel GPS-702. Two stations, spaced within 30 meters, were used in the test. Both had the characteristics similar to the stations of the TAMDEF network, i.e., the UNAVCO fixed-height, force-centered level mounts with a constant antenna offset were used, ensuring extreme stability of the antenna/ mount/pin set up. During each of the four 3-day test data collection

  7. The impact of using jason-1 and cryosat-2 geodetic mission altimetry for gravity field modeling

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Jain, Maulik; Knudsen, Per

    2016-01-01

    Since the release of the Danish Technical University DTU10 global marine gravity field in 2010, the amount of geodetic mission altimetry data has nearly tripled. The Cryosat-2 satellite have provided data along its 369 day near repeat since 2010 and as of May 2012 the Jason-1 satellite has been o...

  8. Geodynamical behavior of some active area in Egypt, as deduced from geodetic and gravity data

    Science.gov (United States)

    Issawy, E.; Mrlina, J.; Radwan, A.; Mahmoud, S.; Rayan, A.

    2009-04-01

    Temporal gravity variation in parallel with the space geodetic technique (GPS) had been started in Egypt for real campaigns in 1997. The geodetic networks around the High Dam, Aswan area was the first net to be measured. More than five measurement epochs were performed. The results had a considerable limit of coincidence between gravity and GPS observations. The trend of gravity changes indicated a positive stress and had the vertical displacement observed for leveling points. The lowest gravity changes along Kalabsha fault reflect extensional and/or strike component of the stress field. Also, the areas around Cairo (Greater Cairo) and due to the occurrence of an earthquake of 1992, such type of measurements were useful for monitoring the recent activity. The data of the geodetic network around Cairo after 5 campaigns showed that, the estimated horizontal velocities for almost all points are 5.5± mm/year in approximately NW-SE direction. The non-tidal changes can explain the dynamic process within the upper crust related to the development of local stress conditions. The trends of gravity changes are more or less coincident with that deduced from GPS deformation analysis and the occurrence of the main shocks in the area. In additions, in 2005 the geodetic network around the southern part of Sinai and the Gulf of Suez were established. One campaign of measurements had been performed and the gravity values were obtained.

  9. A case for inherent geometric and geodetic accuracy in remotely sensed VNIR and SWIR imaging products

    Science.gov (United States)

    Driver, J. M.

    1982-01-01

    Significant aberrations can occur in acquired images which, unless compensated on board the spacecraft, can seriously impair throughput and timeliness for typical Earth observation missions. Conceptual compensations options are advanced to enable acquisition of images with inherent geometric and geodetic accuracy. Research needs are identified which, when implemented, can provide inherently accurate images. Agressive pursuit of these research needs is recommended.

  10. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    Directory of Open Access Journals (Sweden)

    Lopez-Saura Pedro

    2009-07-01

    Full Text Available Abstract Background Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC or squamous cell skin carcinomas (SCSC. Methods Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Results Sixteen elder (median 70 years-old patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination, 40% PR (>30% tumor reduction, and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. Conclusion The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Trial registration Current Controlled Trials RPCEC00000052.

  11. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    International Nuclear Information System (INIS)

    Anasagasti-Angulo, Lorenzo; Garcia-Vega, Yanelda; Barcelona-Perez, Silvia; Lopez-Saura, Pedro; Bello-Rivero, Iraldo

    2009-01-01

    Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN) may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC) or squamous cell skin carcinomas (SCSC). Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Sixteen elder (median 70 years-old) patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination), 40% PR (>30% tumor reduction), and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Current Controlled Trials RPCEC00000052

  12. Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.

    Science.gov (United States)

    Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M

    1989-12-01

    Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage.

  13. Implementation of an electronic medical record system in previously computer-naïve primary care centres: a pilot study from Cyprus.

    Science.gov (United States)

    Samoutis, George; Soteriades, Elpidoforos S; Kounalakis, Dimitris K; Zachariadou, Theodora; Philalithis, Anastasios; Lionis, Christos

    2007-01-01

    The computer-based electronic medical record (EMR) is an essential new technology in health care, contributing to high-quality patient care and efficient patient management. The majority of southern European countries, however, have not yet implemented universal EMR systems and many efforts are still ongoing. We describe the development of an EMR system and its pilot implementation and evaluation in two previously computer-naïve public primary care centres in Cyprus. One urban and one rural primary care centre along with their personnel (physicians and nurses) were selected to participate. Both qualitative and quantitative evaluation tools were used during the implementation phase. Qualitative data analysis was based on the framework approach, whereas quantitative assessment was based on a nine-item questionnaire and EMR usage parameters. Two public primary care centres participated, and a total often health professionals served as EMR system evaluators. Physicians and nurses rated EMR relatively highly, while patients were the most enthusiastic supporters for the new information system. Major implementation impediments were the physicians' perceptions that EMR usage negatively affected their workflow, physicians' legal concerns, lack of incentives, system breakdowns, software design problems, transition difficulties and lack of familiarity with electronic equipment. The importance of combining qualitative and quantitative evaluation tools is highlighted. More efforts are needed for the universal adoption and routine use of EMR in the primary care system of Cyprus as several barriers to adoption exist; however, none is insurmountable. Computerised systems could improve efficiency and quality of care in Cyprus, benefiting the entire population.

  14. Establishment of 2000 National Geodetic Control Network of China and It’s Technological Progress

    Directory of Open Access Journals (Sweden)

    CHEN Junyong

    2007-02-01

    Full Text Available Objectives: 2000’ National Geodetic Control Network of China is an important fundamental scientific engineering project in China. It consists of three parts which are establishment of 2000 National GPS Geodetic Network, its combination adjustment with national astro-geodetic network and 2000 National Gravity Fundamental network. It provides the high precise coordinate reference and gravity reference for three dimensional geo-center national coordinates system and gravity system, respectively. Additionally, it provides precise unified geometric and physical geodesy information for the economic construction, the national defense and the scientific research. Methods: 1. The larger number of data are processed in triple networks adjustment of 2000 National GPS Geodetic Network, which are chosen from the GPS monitoring stations, such as grade A, B of national GPS network , grade 1st and 2nd of national GPS network, crustal movement observation network of China, and others crustal deformation monitoring stations. Finally, the data of 2666 GPS stations are used in the data processing of 2000 National GPS Geodetic Network, including 124 external stations and 2542 internal stations. In order to the results of triple networks adjustment are corresponding to that of three dimensional geo-center coordinates system, ITRF 97 and epoch 2000.0 are chosen as the coordinate reference frame and epoch reference, respectively. The methods of “strong reference” and “weak reference” are combined used in the control data selection of triple networks adjustment. The scale and rotation scales are adopted for each sub network. The least square adjustment is firstly adopted in each sub network adjustment. The data of obvious abnormal baselines are found and rejected firstly. And the method of double factor robust estimation is adopted in the data processing. 2. The combined adjustment of 2000 National GPS Geodetic Network and national astro-geodetic network is

  15. SIRGAS: the core geodetic infrastructure in Latin America and the Caribbean

    Science.gov (United States)

    Sanchez, L.; Brunini, C.; Drewes, H.; Mackern, V.; da Silva, A.

    2013-05-01

    Studying, understanding, and modelling geophysical phenomena, such as global change and geodynamics, require geodetic reference frames with (1) an order of accuracy higher than the magnitude of the effects we want to study, (2) consistency and reliability worldwide (the same accuracy everywhere), and (3) a long-term stability (the same order of accuracy at any time). The definition, realisation, maintenance, and wide-utilisation of the International Terrestrial Reference System (ITRS) are oriented to guarantee a globally unified geometric reference frame with reliability at the mm-level, i.e. the International Terrestrial Reference Frame (ITRF). The densification of the global ITRF in Latin America and The Caribbean is given by SIRGAS (Sistema de Referencia Geocéntrico para Las Américas), primary objective of which is to provide the most precise coordinates in the region. Therefore, SIRGAS is the backbone for all regional projects based on the generation, use, and analysis of geo-referenced data at national as well as at international level. Besides providing the reference for a wide range of scientific applications such as the monitoring of Earth's crust deformations, vertical movements, sea level variations, atmospheric studies, etc., SIRGAS is also the platform for practical applications such as engineering projects, digital administration of geographical data, geospatial data infrastructures, etc. According to this, the present contribution describes the main features of SIRGAS, giving special care to those challenges faced to continue providing the best possible, long-term stable and high-precise reference frame for Latin America and the Caribbean.

  16. Prospective monitoring and self-report of previous falls among older women at high risk of falls and fractures: a study of comparison and agreement.

    Science.gov (United States)

    Garcia, Patrícia A; Dias, João M D; Silva, Silvia L A; Dias, Rosângela C

    2015-01-01

    The identification of the occurrence of falls is an important step for screening and for rehabilitation processes for the elderly. The methods of monitoring these events are susceptible to recording biases, and the choice of the most accurate method remains challenging. (i) To investigate the agreement between retrospective self-reporting and prospective monitoring of methods of recording falls, and (ii) to compare the retrospective self-reporting of falls and the prospective monitoring of falls and recurrent falls over a 12-month period among older women at high risk of falls and fractures. A total of 118 community-dwelling older women with low bone density were recruited. The incidence of falls was monitored prospectively in 116 older women (2 losses) via monthly phone calls over the course of a year. At the end of this monitoring period, the older women were asked about their recall of falls in the same 12-month period. The agreement between the two methods was analyzed, and the sensitivity and specificity of self-reported previous falls in relation to the prospective monitoring were calculated. There was moderate agreement between the prospective monitoring and the retrospective self-reporting of falls in classifying fallers (Kappa = 0.595) and recurrent fallers (Kappa = 0.589). The limits of agreement were 0.35 ± 1.66 falls. The self-reporting of prior falls had a 67.2% sensitivity and a 94.2% specificity in classifying fallers among older women and a 50% sensitivity and a 98.9% specificity in classifying recurrent fallers. Self-reporting of falls over a 12-month period underestimated 32.8% of falls and 50% of recurrent falls. The findings recommend caution if one is considering replacing monthly monitoring with annual retrospective questioning.

  17. The importance of continued exercise participation in quality of life and psychological well-being in previously inactive postmenopausal women: a pilot study.

    Science.gov (United States)

    Asbury, Elizabeth A; Chandrruangphen, Pornpat; Collins, Peter

    2006-01-01

    Exercise and physical activity provide a wide range of health benefits for postmenopausal women, although the impact of maintained exercise participation on psychological well-being is unclear. An exploration of continued exercise participation in psychological well-being after a moderate-intensity exercise program in previously inactive postmenopausal women was therefore undertaken. : Twenty-three healthy sedentary postmenopausal women (age 56 +/- 4 years) were randomly assigned to two groups. All participants completed the Short Form-36, Hospital Anxiety and Depression Scale (HADS), and Health Anxiety Questionnaire (HAQ) and then began a 6-week walking program at 50% heart rate reserve defined by (.-)V(O(2)) treadmill testing. Post-intervention, all participants underwent (.-)V(O(2)) treadmill testing and questionnaires. Group 1 was then instructed to continue exercising, whereas group 2 was instructed to desist for an additional 6-week period. On completion of the 6-week follow-up, participants completed a final set of questionnaires. Participants performed 97% of the prescribed 15-hour (900 minute) exercise program (875.1 +/- 177.4 minutes) in an average of 26 +/- 5 sessions. Total HAQ (P = 0.001), health worry (P = 0.001), fear of illness (P = 0.037), reassurance seeking behavior (P = 0.037), SF-36 well-being (P = 0.037), total HADS (P = 0.019), and HADS depression (P = 0.015) improved significantly following the exercise program. At follow-up, group 1 had lower HADS anxiety (P = 0.013), total HADS (P = 0.02), total HAQ (P = 0.03), and HAQ interference with life (P = 0.03) and significantly higher SF-36 energy (P = 0.01) than group 2. Healthy postmenopausal women gain significant psychological benefit from moderate-intensity exercise. However, exercise participation must continue to maintain improvements in psychological well-being and quality of life.

  18. Comparison between geodetic and oceanographic approaches to estimate mean dynamic topography for vertical datum unification: evaluation at Australian tide gauges

    Science.gov (United States)

    Filmer, M. S.; Hughes, C. W.; Woodworth, P. L.; Featherstone, W. E.; Bingham, R. J.

    2018-04-01

    The direct method of vertical datum unification requires estimates of the ocean's mean dynamic topography (MDT) at tide gauges, which can be sourced from either geodetic or oceanographic approaches. To assess the suitability of different types of MDT for this purpose, we evaluate 13 physics-based numerical ocean models and six MDTs computed from observed geodetic and/or ocean data at 32 tide gauges around the Australian coast. We focus on the viability of numerical ocean models for vertical datum unification, classifying the 13 ocean models used as either independent (do not contain assimilated geodetic data) or non-independent (do contain assimilated geodetic data). We find that the independent and non-independent ocean models deliver similar results. Maximum differences among ocean models and geodetic MDTs reach >150 mm at several Australian tide gauges and are considered anomalous at the 99% confidence level. These differences appear to be of geodetic origin, but without additional independent information, or formal error estimates for each model, some of these errors remain inseparable. Our results imply that some ocean models have standard deviations of differences with other MDTs (using geodetic and/or ocean observations) at Australian tide gauges, and with levelling between some Australian tide gauges, of ˜ ± 50 mm . This indicates that they should be considered as an alternative to geodetic MDTs for the direct unification of vertical datums. They can also be used as diagnostics for errors in geodetic MDT in coastal zones, but the inseparability problem remains, where the error cannot be discriminated between the geoid model or altimeter-derived mean sea surface.

  19. Identifying and Allocating Geodetic Systems to historical oil gas wells by using high-resolution satellite imagery

    Science.gov (United States)

    Alvarez, Gabriel O.

    2018-05-01

    Hydrocarbon exploration in Argentina started long before the IGM created a single, high-precision geodetic reference network for the whole country. Several geodetic surveys were conducted in every producing basin, which have ever since then supported well placement. Currently, every basin has a huge amount of information referenced to the so-called "local" geodetic systems, such as Chos Malal - Quiñi Huao in the Neuquén Basin, and Pampa del Castillo in the San Jorge Basin, which differ to a greater or lesser extent from the national Campo Inchauspe datum established by the IGM in 1969 as the official geodetic network. However, technology development over the last few years and the expansion of satellite positioning systems such as GPS resulted in a new world geodetic order. Argentina rapidly joined this new geodetic order through the implementation of a new national geodetic system by the IGM: POSGAR network, which replaced the old national Campo Inchauspe system. However, this only helped to worsen the data georeferencing issue for oil companies, as a third reference system was added to each basin. Now every basin has a local system, the national system until 1997 (Campo Inchauspe), and finally the newly created POSGAR network national satellite system, which is geocentric unlike the former two planimetric datums. The purpose of this paper is to identify and allocate geodetic systems of coordinates to historical wells, whose geodetic system is missing or has been erroneously allocated, by using currently available technological resources such as geographic information systems and high-resolution satellite imagery.

  20. Geodetic Measurements and Numerical Modeling of the Deformation Cycle for Okmok Volcano, Alaska: 1993-2008

    Science.gov (United States)

    Ohlendorf, S. J.; Feigl, K.; Thurber, C. H.; Lu, Z.; Masterlark, T.

    2011-12-01

    Okmok Volcano is an active caldera located on Umnak Island in the Aleutian Island arc. Okmok, having recently erupted in 1997 and 2008, is well suited for multidisciplinary studies of magma migration and storage because it hosts a good seismic network and has been the subject of synthetic aperture radar (SAR) images that span the recent eruption cycle. Interferometric SAR can characterize surface deformation in space and time, while data from the seismic network provides important information about the interior processes and structure of the volcano. We conduct a complete time series analysis of deformation of Okmok with images collected by the ERS and Envisat satellites on more than 100 distinct epochs between 1993 and 2008. We look for changes in inter-eruption inflation rates, which may indicate inelastic rheologic effects. For the time series analysis, we analyze the gradient of phase directly, without unwrapping, using the General Inversion of Phase Technique (GIPhT) [Feigl and Thurber, 2009]. This approach accounts for orbital and atmospheric effects and provides realistic estimates of the uncertainties of the model parameters. We consider several models for the source, including the prolate spheroid model and the Mogi model, to explain the observed deformation. Using a medium that is a homogeneous half space, we estimate the source depth to be centered at about 4 km below sea level, consistent with the findings of Masterlark et al. [2010]. As in several other geodetic studies, we find the source to be approximately centered beneath the caldera. To account for rheologic complexity, we next apply the Finite Element Method to simulate a pressurized cavity embedded in a medium with material properties derived from body wave seismic tomography. This approach allows us to address the problem of unreasonably large pressure values implied by a Mogi source with a radius of about 1 km by experimenting with larger sources. We also compare the time dependence of the

  1. Geodetic Mass Balance of the Northern Patagonian Icefield from 2000 to 2012 Using Two Independent Methods

    Directory of Open Access Journals (Sweden)

    Inés Dussaillant

    2018-02-01

    Full Text Available We compare two independent estimates of the rate of elevation change and geodetic mass balance of the Northern Patagonian Icefield (NPI between 2000 (3,856 km2 and 2012 (3,740 km2 from space-borne data. The first is obtained by differencing the Shuttle Radar Topography Mission (SRTM digital elevation model (DEM from February 2000 and a Satellite pour l'Observation de la Terre 5 (SPOT5 DEM from March 2012. The second is deduced by fitting pixel-based linear elevation trends over 118 DEMs calculated from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER stereo images acquired between 2000 and 2012. Both methods lead to similar and strongly negative icefield-wide mass balance rates of −1.02 ± 0.21 and −1.06 ± 0.14 m w.e. yr−1 respectively, which is in agreement with earlier studies. Contrasting glacier responses are observed, with individual glacier mass balance rates ranging from −0.15 to −2.30 m w.e. yr−1 (standard deviation = 0.49 m w.e. yr−1; N = 38. For individual glaciers, the two methods agree within error bars, except for small glaciers poorly sampled in the SPOT5 DEM due to clouds. Importantly, our study confirms the lack of penetration of the C-band SRTM radar signal into the NPI snow and firn except for a region above 2,900 m a.s.l. covering <1% of the total area. Ignoring penetration would bias the mass balance by only 0.005 m w.e. yr−1. A strong advantage of the ASTER method is that it relies only on freely available data and can thus be extended to other glacierized areas.

  2. Integrating Geological and Geodetic Surveying Techniques for Landslide Deformation Monitoring: Istanbul Case

    Science.gov (United States)

    Menteşe, E. Y.; Kilic, O.; BAS, M.; Tarih, A.; Duran, K.; Gumus, S.; Yapar, E. R.; Karasu, M. E.; Mehmetoğlu, H.; Karaman, A.; Edi˙ger, V.; Kosma, R. C.; Ozalaybey, S.; Zor, E.; Arpat, E.; Polat, F.; Dogan, U.; Cakir, Z.; Erkan, B.

    2017-12-01

    There are several methods that can be utilized for describing the landslide mechanisms. While some of them are commonly used, there are relatively new methods that have been proven to be useful. Obviously, each method has its own limitations and thus integrated use of these methods contributes to obtaining a realistic landslide model. The slopes of Küçükçekmece and Büyükçekmece Lagoons located at the Marmara Sea coast of İstanbul, Turkey, are among most specific examples of complex type landslides. The landslides in the area started developing at low sea level, and appears to ceased or at least slowed down to be at minimum after the sea level rise, as oppose to the still-active landslides that continue to cause damage especially in the valley slopes above the recent sea level between the two lagoons. To clarify the characteristics of these slope movements and classify them in most accurate way, Directorate of Earthquake and Ground Research of Istanbul Metropolitan Municipality launched a project in cooperation with Marmara Research Center of The Scientific and Technological Research Council of Turkey (TÜBİTAK). The project benefits the utility of the techniques of different disciplines such as geology, geophysics, geomorphology, hydrogeology, geotechnics, geodesy, remote sensing and meteorology. Specifically, this study focuses on two main axes of these techniques, namely: geological and geodetic. The reason for selecting these disciplines is because of their efficiency and power to understand the landslide mechanism in the area. Main approaches used in these studies are comprised of geological drills, inclinometer measurements, GPS surveys and SAR (both satellite and ground based) techniques. Integration of the results gathered from these techniques led the project team to comprehend critical aspects of landslide phenomenon in the area and produce precise landslide hazard maps that are basic instruments for a resilient urban development.

  3. The possibility of previous epidemiological data to serve as baseline for future national oral health surveys--a study in Vietnam.

    NARCIS (Netherlands)

    Palenstein Helderman, W.H. van; Truin, G.J.; Can, N.; Khanh, N.D.

    2001-01-01

    AIM: The purpose of this paper is to review the most recent epidemiological data (1985-2000) on dental caries and periodontal diseases in Vietnam in an attempt to obtain a 'baseline' for future national oral health surveys. METHODS: Studies on periodontal diseases and caries were included when CPITN

  4. Low degree Earth's gravity coefficients determined from different space geodetic observations and climate models

    Science.gov (United States)

    Wińska, Małgorzata; Nastula, Jolanta

    2017-04-01

    Large scale mass redistribution and its transport within the Earth system causes changes in the Earth's rotation in space, gravity field and Earth's ellipsoid shape. These changes are observed in the ΔC21, ΔS21, and ΔC20 spherical harmonics gravity coefficients, which are proportional to the mass load-induced Earth rotational excitations. In this study, linear trend, decadal, inter-annual, and seasonal variations of low degree spherical harmonics coefficients of Earth's gravity field, determined from different space geodetic techniques, Gravity Recovery and Climate Experiment (GRACE), satellite laser ranging (SLR), Global Navigation Satellite System (GNSS), Earth rotation, and climate models, are examined. In this way, the contribution of each measurement technique to interpreting the low degree surface mass density of the Earth is shown. Especially, we evaluate an usefulness of several climate models from the Coupled Model Intercomparison Project phase 5 (CMIP5) to determine the low degree Earth's gravity coefficients using GRACE satellite observations. To do that, Terrestrial Water Storage (TWS) changes from several CMIP5 climate models are determined and then these simulated data are compared with the GRACE observations. Spherical harmonics ΔC21, ΔS21, and ΔC20 changes are calculated as the sum of atmosphere and ocean mass effect (GAC values) taken from GRACE and a land surface hydrological estimate from the selected CMIP5 climate models. Low degree Stokes coefficients of the surface mass density determined from GRACE, SLR, GNSS, Earth rotation measurements and climate models are compared to each other in order to assess their consistency. The comparison is done by using different types of statistical and signal processing methods.

  5. From Geodetic Imaging of Seismic and Aseismic Fault Slip to Dynamic Modeling of the Seismic Cycle

    Science.gov (United States)

    Avouac, Jean-Philippe

    2015-05-01

    Understanding the partitioning of seismic and aseismic fault slip is central to seismotectonics as it ultimately determines the seismic potential of faults. Thanks to advances in tectonic geodesy, it is now possible to develop kinematic models of the spatiotemporal evolution of slip over the seismic cycle and to determine the budget of seismic and aseismic slip. Studies of subduction zones and continental faults have shown that aseismic creep is common and sometimes prevalent within the seismogenic depth range. Interseismic coupling is generally observed to be spatially heterogeneous, defining locked patches of stress accumulation, to be released in future earthquakes or aseismic transients, surrounded by creeping areas. Clay-rich tectonites, high temperature, and elevated pore-fluid pressure seem to be key factors promoting aseismic creep. The generally logarithmic time evolution of afterslip is a distinctive feature of creeping faults that suggests a logarithmic dependency of fault friction on slip rate, as observed in laboratory friction experiments. Most faults can be considered to be paved with interlaced patches where the friction law is either rate-strengthening, inhibiting seismic rupture propagation, or rate-weakening, allowing for earthquake nucleation. The rate-weakening patches act as asperities on which stress builds up in the interseismic period; they might rupture collectively in a variety of ways. The pattern of interseismic coupling can help constrain the return period of the maximum- magnitude earthquake based on the requirement that seismic and aseismic slip sum to match long-term slip. Dynamic models of the seismic cycle based on this conceptual model can be tuned to reproduce geodetic and seismological observations. The promise and pitfalls of using such models to assess seismic hazard are discussed.

  6. Recent surface displacements in the Upper Rhine Graben — Preliminary results from geodetic networks

    Science.gov (United States)

    Fuhrmann, Thomas; Heck, Bernhard; Knöpfler, Andreas; Masson, Frédéric; Mayer, Michael; Ulrich, Patrice; Westerhaus, Malte; Zippelt, Karl

    2013-08-01

    Datasets of the GNSS Upper Rhine Graben Network (GURN) and the national levelling networks in Germany, France and Switzerland are investigated with respect to current surface displacements in the Upper Rhine Graben (URG) area. GURN consists of about 80 permanent GNSS (Global Navigation Satellite Systems) stations. The terrestrial levelling network comprises 1st and 2nd order levelling lines that have been remeasured at intervals of roughly 25 years, starting in 1922. Compared to earlier studies national institutions and private companies made available raw data, allowing for consistent solutions for the URG region. We focussed on the southern and eastern parts of the investigation area. Our preliminary results show that the levelling and GNSS datasets are sensitive to resolve small surface displacement rates down to an order of magnitude of 0.2 mm/a and 0.4 mm/a, respectively. The observed horizontal velocity components for a test region south of Strasbourg, obtained from GNSS coordinate time series, vary around 0.5 mm/a. The results are in general agreement with interseismic strain built-up in a sinistral strike-slip regime. Since the accuracy of the GNSS derived vertical component is insufficient, data of precise levelling networks is used to determine vertical displacement rates. More than 75% of the vertical rates obtained from a kinematic adjustment of 1st order levelling lines in the eastern part of URG vary between - 0.2 mm/a and + 0.2 mm/a, indicating that this region behaves stable. Higher rates up to 0.5 mm/a in a limited region south of Freiburg are in general agreement with active faulting. We conclude that both networks deliver stable results that reflect real surface movements in the URG area. We note, however, that geodetically observed surface displacements generally result from a superposition of different effects, and that a separation in tectonic and non-tectonic processes needs additional information and expertise.

  7. Alfalfa (Medicago sativa L.) is tolerant to higher levels of salinity than previous guidelines indicated: Implications of field and greenhouse studies

    Science.gov (United States)

    Putnam, Daniel H.; Benes, Sharon; Galdi, Giuliano; Hutmacher, Bob; Grattan, Steve

    2017-04-01

    Alfalfa (Medicago sativa L.) is the most widely grown leguminous forage crop in North America and is valued for high productivity, quality, economic value, and for dairy productivity. Alfalfa has historically been classified as moderately sensitive to saline conditions, with yield declines predicted at >2 dS/m in the saturated soil paste extract. However, greenhouse, sand tank, and field studies over the past five years have confirmed that alfalfa can be grown with limited negative effects at much higher salinity levels. A broad collection of alfalfa varieties has exhibited a range of resistance at irrigation water salinities >5 dS/m ECw in greenhouse trials, with significant variation due to variety. USDA-ARS sand tank studies indicated similar or greater tolerances closer to 8 dS/m in the soil water, in addition to confirmation of significant varietal differences. A three-year field study on clay loam soil with applications of 5-7 dS/m ECw irrigation water indicated normal yields and excellent stand survivability. A second field study in the same soil type with levels from 8-10 dS/m ECw showed yield reductions of 10-15% but economic yields were still achieved at those levels. Field and greenhouse studies were conducted with mixed salt saline sodic waters typical of the San Joaquin Valley of California. Field evaluation of variety performance was subject to greater variation due to secondary salinity-soil interactions including water infiltration and crusting problems, not only salinity per-se. Thus, adequate irrigation water availability to the crop may be as important as salinity in impacting yields under field conditions. Once established, the deep-rooted characteristics of alfalfa enable utilization of deeper subsurface moisture, even at moderate to high salinity levels, as documented by USDA lysimeter studies. Significant advantages to salinity-tolerant varieties have been observed. It will be important to consider specific management factors which may enable

  8. A study of tectonic activity in the Basin-Range Province and on the San Andreas Fault. No. 3: Kinematics of Great Basin intraplate extension from earthquake, geodetic and geologic information. Final Technical Report, 15 Apr. 1981 - 31 Jan. 1986 M.S. Thesis

    Science.gov (United States)

    Eddington, P. K.

    1986-01-01

    Strain rates assessed from brittle fracture, associated with earthquakes, and total brittle-ductile deformation measured from geodetic data were compared to paleostrain from Quaternary geology for the intraplate Great Basin of the western United States. These data provide an assessment of the kinematics and mode of lithospheric extension that the western U.S. Cordillera has experienced in the last 5 to 10 million years. Strain and deformation rates were determined by the seismic moment tensor method using historic seismicity and fault plane solutions. Contemporary deformation of the Great Basin occurs principally along the active seismic zones. The earthquake related strain shows that the Great Basin is characterized by regional E-W extension at 8.4 mm/a in the north that diminishes to NW-SE extension of 3.5 mm/a in the south. Zones of maximum extension correspond to belts of shallow crust, high heat flow, and Quaternary basaltic volcanism, suggesting that these parameters are related through an effect such as a stress relaxation allowing bouyant uplift and ascension of magmas.

  9. Effect of benzalkonium chloride?free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study

    OpenAIRE

    Lopes, Joao F.; Hubatsch, Douglas A.; Amaris, Patricia

    2015-01-01

    Background Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). Methods This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005?% were transitioned to recei...

  10. Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study.

    Science.gov (United States)

    Lopes, Joao F; Hubatsch, Douglas A; Amaris, Patricia

    2015-11-12

    Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005 % were transitioned to receive once-daily BAK-free travoprost 0.004 % containing polyquaternium-1 (Travatan® preserved with POLYQUAD® [PQ], Alcon Laboratories, Inc; Fort Worth, TX) for 12 weeks. Mean change in IOP from baseline (primary efficacy endpoint) and the percentage of patients who achieved a target IOP of ≤18 mmHg were evaluated at all on-therapy visits. Ocular hyperemia, patient preference, and self-projected adherence were assessed at week 12. Adverse events (AEs) were monitored throughout the study. All enrolled patients were included in the analysis (n = 191); the majority of patients (90.6 %, n = 173/191) completed the study. Mean (SD) patient age was 67.5 (11.3) years, and mean baseline IOP was 14.8 mmHg. Mean IOP was reduced by 0.94 mmHg at week 6 and by 1.09 mmHg at week 12 (P glaucoma or ocular hypertension who were intolerant of latanoprost. BAK-free travoprost 0.004 % is a viable alternative for patients who require switching their IOP-lowering medications because of tolerability issues. ClinicalTrials.gov identifier, NCT01510145.

  11. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

    DEFF Research Database (Denmark)

    Forner, Lone; Hansen, Ole Hyldegaard; von Brockdorff, Annet Schack

    2011-01-01

    in irradiated head and neck cancer patients. Eighty patients eligible for HBO treatment on the indication of prevention/treatment of osteoradionecrosis or soft tissue radiation injury were consecutively sampled, of whom 45 had hyposalivation (i.e. unstimulated whole saliva (UWS) flow rate......Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO...

  12. Previous study for the setting up and optimization of detection of ZnS(Ag) scintillation applied to the measure of alpha radioactivity index

    International Nuclear Information System (INIS)

    Pujol, L.; Suarez-Navarro, J.A.; Montero, M.

    1998-01-01

    The determination of radiological water quality is useful for a wide range of environmental studies. In these cases, the gross alpha activity is one of the parameters to determine. This parameter permits to decide if further radiological analyses are necessary in order to identify and quantify the presence of alpha emitters in water. The usual method for monitoring the gross alpha activity includes sample evaporation to dryness on a disk and counting using ZnS(Ag) scintillation detector. Detector electronics is provided with two components which are adjustable by the user the high-voltage applied to the photomultiplier tubes and the low level discriminator that is used to eliminate the electronic noise. The high-voltage and low level discriminator optimization are convenient in order to reach the best counting conditions. This paper is a preliminary study of the procedure followed for the setting up and optimization of the detector electronics in the laboratories of CEDEX for the measurement of gross alpha activity. (Author)

  13. [Mutations of resistance of HIV-1 in previously untreated patients at penitentiary centers of the Autonomous Community of Valencia, Spain. REPRICOVA study].

    Science.gov (United States)

    García-Guerrero, Julio; Herrero, Agustín; Vera, Enrique; Almenara, José M; Araújo, Rosa; Saurí, Vicente V; Castellano, Juan C; Fernández-Clemente, Luis; Bedia, Miguel; Llorente, María I; González-Morán, Francisco

    2002-03-02

    Our purpose was to determine the prevalence of mutations of resistance to nucleoside inhibitors of reverse transcriptase (NIRT) and protease inhibitors (PI) in the HIV-1 genotype of naïve infected subjects in the prisons of the Autonomous Community of Valencia, Spain. Multicentric, descriptive, cross-sectional study of prevalence including a systematic stratified and randomised sampling by centres. Demographic, clinical, virological and immunological data were collected. The HIV gene of protease and transcriptase was studied in peripheral blood plasma samples by means of double PCR amplification and subsequent automatic sequence. Reference: wild strain HXB2. Plasma was obtained from 133 individuals (119 men and 14 women). 117 samples were selected and the rest did not have enough copies for transcription. With regard to NIRT, 7 samples (5.2% of total) showed some mutation of resistance: M41L, D67N, L210W and K219Q, all them secondary to and associated with resistance to zidovudine, abacavir as well as group B multinucleoside-resistance. With regard to PI, only one sample showed a primary mutation, M46I, which was associated with resistance to indinavir. Moreover, a further 41 samples were found to express some secondary mutation. In our series, there was a low number of primary mutations of resistance. These results allow us to exclude the systematic use of resistance tests before an initiation antiretroviral therapy.

  14. In Vitro Fertilization Outcomes After Placement of Essure Microinserts in Patients With Hydrosalpinges Who Previously Failed In Vitro Fertilization Treatment: A Multicenter Study.

    Science.gov (United States)

    Cohen, Shlomo B; Bouaziz, Jerome; Schiff, Eyal; Simon, Alexander; Nadjary, Michel; Goldenberg, Mordechai; Orvieto, Raoul; Revel, Ariel

    2016-01-01

    To investigate whether hysteroscopic proximal tubal occlusion with Essure microinserts (Conceptus Inc.; Bayer, AG, North Rhine-Westphalia, Germany) can improve pregnancy rates in patients with hydrosalpinges who had failed in vitro fertilization (IVF) treatment. A prospective cohort study. University-affiliated tertiary centers. Twenty-four consecutive women with hydrosalpinges who had failed IVF treatment were included. Hysteroscopic placement of Essure microinserts for hydrosalpinx blockage followed by IVF treatment. Ongoing pregnancy and live birth rates were recorded. Of the 24 patients undergoing a total of 42 IVF cycles after Essure insertion, 18 (75% of patients and 42.8% of IVF cycle attempts) conceived and 16 delivered live births (66.6% of patients and 38.1% of IVF cycle attempts). Hysteroscopic proximal occlusion of hydrosalpinges with Essure microinserts is a valuable alternative to laparoscopic salpingectomy, resulting in reasonable pregnancy rates. Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

  15. Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Patients With Chronic Kidney Disease Without Previously Diagnosed Heart Failure: Chronic Renal Insufficiency Cohort Study.

    Science.gov (United States)

    Mishra, Rakesh K; Yang, Wei; Roy, Jason; Anderson, Amanda H; Bansal, Nisha; Chen, Jing; DeFilippi, Christopher; Delafontaine, Patrice; Feldman, Harold I; Kallem, Radhakrishna; Kusek, John W; Lora, Claudia M; Rosas, Sylvia E; Go, Alan S; Shlipak, Michael G

    2015-07-01

    Chronic kidney disease is a risk factor for heart failure (HF). Patients with chronic kidney disease without diagnosed HF have an increased burden of symptoms characteristic of HF. It is not known whether these symptoms are associated with occurrence of new onset HF. We studied the association of a modified Kansas City Cardiomyopathy Questionnaire with newly identified cases of hospitalized HF among 3093 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study who did not report HF at baseline. The annually updated Kansas City Cardiomyopathy Questionnaire score was categorized into quartiles (Q1-4) with the lower scores representing the worse symptoms. Multivariable-adjusted repeated measure logistic regression models were adjusted for demographic characteristics, clinical risk factors for HF, N-terminal probrain natriuretic peptide level and left ventricular hypertrophy, left ventricular systolic and diastolic dysfunction. Over a mean (±SD) follow-up period of 4.3±1.6 years, there were 211 new cases of HF hospitalizations. The risk of HF hospitalization increased with increasing symptom quartiles; 2.62, 1.85, 1.14, and 0.74 events per 100 person-years, respectively. The median number of annual Kansas City Cardiomyopathy Questionnaire assessments per participant was 5 (interquartile range, 3-6). The annually updated Kansas City Cardiomyopathy Questionnaire score was independently associated with higher risk of incident HF hospitalization in multivariable-adjusted models (odds ratio, 3.30 [1.66-6.52]; P=0.001 for Q1 compared with Q4). Symptoms characteristic of HF are common in patients with chronic kidney disease and are associated with higher short-term risk for new hospitalization for HF, independent of level of kidney function, and other known HF risk factors. © 2015 American Heart Association, Inc.

  16. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study

    International Nuclear Information System (INIS)

    Weber, Damien C; Miralbell, Raymond; Wang, Hui; Cozzi, Luca; Dipasquale, Giovanna; Khan, Haleem G; Ratib, Osman; Rouzaud, Michel; Vees, Hansjoerg; Zaidi, Habib

    2009-01-01

    A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT. Plans for RA, IMRT and IMPT were optimized for 7 patients. Prescribed dose was 56 Gy in 14 fractions. The recurrent gross tumor volume (GTV) was defined on 18 F-fluorocholine PET/CT scans. Plans aimed to cover at least 95% of the planning target volume with a dose > 50.4 Gy. A maximum dose (D Max ) of 61.6 Gy was allowed to 5% of the GTV. For the urethra, D Max was constrained to 37 Gy. Rectal D Median was < 17 Gy. Results were analyzed using Dose-Volume Histogram and conformity index (CI 90 ) parameters. Tumor coverage (GTV and PTV) was improved with RA (V 95% 92.6 ± 7.9 and 83.7 ± 3.3%), when compared to IMRT (V 95% 88.6 ± 10.8 and 77.2 ± 2.2%). The corresponding values for IMPT were intermediate for the GTV (V 95% 88.9 ± 10.5%) and better for the PTV (V 95% 85.6 ± 5.0%). The percentages of rectal and urethral volumes receiving intermediate doses (35 Gy) were significantly decreased with RA (5.1 ± 3.0 and 38.0 ± 25.3%) and IMPT (3.9 ± 2.7 and 25.1 ± 21.1%), when compared to IMRT (9.8 ± 5.3 and 60.7 ± 41.7%). CI 90 was 1.3 ± 0.1 for photons and 1.6 ± 0.2 for protons. Integral Dose was 1.1 ± 0.5 Gy*cm 3 *10 5 for IMPT and about a factor three higher for all photon's techniques. RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk

  17. Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma.

    Science.gov (United States)

    Raje, Noopur S; Moreau, Philippe; Terpos, Evangelos; Benboubker, Lotfi; Grząśko, Norbert; Holstein, Sarah A; Oriol, Albert; Huang, Shang-Yi; Beksac, Meral; Kuliczkowski, Kazimierz; Tai, Datchen F; Wooldridge, James E; Conti, Ilaria; Kaiser, Christopher J; Nguyen, Tuan S; Cronier, Damien M; Palumbo, Antonio

    2017-03-01

    In this double-blind, Phase 2 study, 220 patients with relapsed/refractory multiple myeloma were randomly assigned 1:1:1 to receive placebo (N = 72), tabalumab 100 mg (N = 74), or tabalumab 300 mg (N = 74), each in combination with dexamethasone 20 mg and subcutaneous bortezomib 1·3 mg/m 2 on a 21-day cycle. No significant intergroup differences were observed among primary (median progression-free survival [mPFS]) or secondary efficacy outcomes. The mPFS was 6·6, 7·5 and 7·6 months for the tabalumab 100, 300 mg and placebo groups, respectively (tabalumab 100 mg vs. placebo Hazard ratio (HR) [95% confidence interval (CI)] = 1·13 [0·80-1·59], P = 0·480; tabalumab 300 mg vs. placebo HR [95% CI] = 1·03 [0·72-1·45], P = 0·884). The most commonly-reported treatment-emergent adverse events were thrombocytopenia (37%), fatigue (37%), diarrhoea (35%) and constipation (32%). Across treatments, patients with low baseline BAFF (also termed TNFSF13B) expression (n = 162) had significantly longer mPFS than those with high BAFF expression (n = 55), using the 75th percentile cut-off point (mPFS [95% CI] = 8·3 [7·0-9·3] months vs. 5·8 [3·7-6·6] months; HR [95% CI] = 1·59 [1·11-2·29], P = 0·015). Although generally well tolerated, PFS was not improved during treatment with tabalumab compared to placebo. A higher dose of 300 mg tabalumab did not improve efficacy compared to the 100 mg dose. Nonetheless, BAFF appears to have some prognostic value in patients with multiple myeloma. © 2016 John Wiley & Sons Ltd.

  18. Previously unknown species of Aspergillus.

    Science.gov (United States)

    Gautier, M; Normand, A-C; Ranque, S

    2016-08-01

    The use of multi-locus DNA sequence analysis has led to the description of previously unknown 'cryptic' Aspergillus species, whereas classical morphology-based identification of Aspergillus remains limited to the section or species-complex level. The current literature highlights two main features concerning these 'cryptic' Aspergillus species. First, the prevalence of such species in clinical samples is relatively high compared with emergent filamentous fungal taxa such as Mucorales, Scedosporium or Fusarium. Second, it is clearly important to identify these species in the clinical laboratory because of the high frequency of antifungal drug-resistant isolates of such Aspergillus species. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been shown to enable the identification of filamentous fungi with an accuracy similar to that of DNA sequence-based methods. As MALDI-TOF MS is well suited to the routine clinical laboratory workflow, it facilitates the identification of these 'cryptic' Aspergillus species at the routine mycology bench. The rapid establishment of enhanced filamentous fungi identification facilities will lead to a better understanding of the epidemiology and clinical importance of these emerging Aspergillus species. Based on routine MALDI-TOF MS-based identification results, we provide original insights into the key interpretation issues of a positive Aspergillus culture from a clinical sample. Which ubiquitous species that are frequently isolated from air samples are rarely involved in human invasive disease? Can both the species and the type of biological sample indicate Aspergillus carriage, colonization or infection in a patient? Highly accurate routine filamentous fungi identification is central to enhance the understanding of these previously unknown Aspergillus species, with a vital impact on further improved patient care. Copyright © 2016 European Society of Clinical Microbiology and

  19. GOZCARDS Source Data for Ozone Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Ozone Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpO3) contains zonal means and related information...

  20. GOZCARDS Source Data for Nitrous Oxide Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Nitrous Oxide Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpN2O) contains zonal means and related...

  1. GOZCARDS Source Data for Temperature Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid V1.00

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Temperature Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpT) contains zonal means and related...

  2. GOZCARDS Source Data for Nitric Acid Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Source Data for Nitric Acid Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozSmlpHNO3) contains zonal means and related...

  3. Global geodetic observing system meeting the requirements of a global society on a changing planet in 2020

    CERN Document Server

    Plag, Hans-Peter

    2009-01-01

    Geodesy plays a key role in geodynamics, geohazards, the global water cycle, global change, atmosphere and ocean dynamics. This book covers geodesy's contribution to science and society and identifies user needs regarding geodetic observations and products.

  4. GOZCARDS Merged Data for Nitrous Oxide Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Nitrous Oxide Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpN2O) contains zonal means and related...

  5. GOZCARDS Merged Data for Water Vapor Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Water Vapor Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpH2O) contains zonal means and related...

  6. GOZCARDS Merged Data for Hydrogen Chloride Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Hydrogen Chloride Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpHCl) contains zonal means and related...

  7. GOZCARDS Merged Data for Ozone Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Ozone Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpO3) contains zonal means and related information...

  8. GOZCARDS Merged Data for Nitric Acid Monthly Zonal Means on a Geodetic Latitude and Pressure Grid V1.01

    Data.gov (United States)

    National Aeronautics and Space Administration — The GOZCARDS Merged Data for Nitric Acid Monthly Zonal Averages on a Geodetic Latitude and Pressure Grid product (GozMmlpHNO3) contains zonal means and related...

  9. Agile Big Data Analytics of High-Volume Geodetic Data Products for Improving Science and Hazard Response

    Data.gov (United States)

    National Aeronautics and Space Administration — Geodetic imaging is revolutionizing geophysics, but the scope of discovery has been limited by labor-intensive technological implementation of the analyses. The...

  10. Monitoring Coral Growth - the Dichotomy Between Underwater Photogrammetry and Geodetic Control Network

    Science.gov (United States)

    Neyer, F.; Nocerino, E.; Gruen, A.

    2018-05-01

    Creating 3-dimensional (3D) models of underwater scenes has become a common approach for monitoring coral reef changes and its structural complexity. Also in underwater archeology, 3D models are often created using underwater optical imagery. In this paper, we focus on the aspect of detecting small changes in the coral reef using a multi-temporal photogrammetric modelling approach, which requires a high quality control network. We show that the quality of a good geodetic network limits the direct change detection, i.e., without any further registration process. As the photogrammetric accuracy is expected to exceed the geodetic network accuracy by at least one order of magnitude, we suggest to do a fine registration based on a number of signalized points. This work is part of the Moorea Island Digital Ecosystem Avatar (IDEA) project that has been initiated in 2013 by a group of international researchers (https://mooreaidea.ethz.ch/).

  11. Seismic and Geodetic Monitoring of the Nicoya, Costa Rica, Seismic Gap

    Science.gov (United States)

    Protti, M.; Gonzalez, V.; Schwartz, S.; Dixon, T.; Kato, T.; Kaneda, Y.; Simila, G.; Sampson, D.

    2007-05-01

    The Nicoya segment of the Middle America Trench has been recognized as a mature seismic gap with potential to generate a large earthquake in the near future (it ruptured with large earthquakes in 1853, 1900 and 1950). Low level of background seismicity and fast crustal deformation of the forearc are indicatives of strong coupling along the plate interface. Given its high seismic potential, the available data and especially the fact that the Nicoya peninsula extends over large part of the rupture area, this gap was selected as one of the two sites for a MARGINS-SEIZE experiment. With the goal of documenting the evolution of loading and stress release along this seismic gap, an international effort involving several institutions from Costa Rica, the United States and Japan is being carried out for over a decade in the region. This effort involves the installation of temporary and permanent seismic and geodetic networks. The seismic network includes short period, broad band and strong motion instruments. The seismic monitoring has provided valuable information on the geometry and characteristics of the plate interface. The geodetic network includes temporary and permanent GPS stations as well as surface and borehole tiltmeters. The geodetic networks have helped quantify the extend and degree of coupling. A continuously recording, three- station GPS network on the Nicoya Peninsula, Costa Rica, recorded what we believe is the first slow slip event observed along the plate interface of the Costa Rica subduction zone. We will present results from these monitoring networks. Collaborative international efforts are focused on expanding these seismic and geodetic networks to provide improved resolution of future creep events, to enhanced understanding of the mechanical behavior of the Nicoya subduction segment of the Middle American Trench and possibly capture the next large earthquake and its potential precursor deformation.

  12. Review of previous geophysical and geological studies

    Digital Repository Service at National Institute of Oceanography (India)

    Levchenko, O.V.; Neprochnov, Y.P; Rao, D.G; Subrahmanyam, C.; Murthy, K.S

    stream_size 5 stream_content_type text/plain stream_name Mem_Geol_Soc_India_39_5.pdf.txt stream_source_info Mem_Geol_Soc_India_39_5.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  13. Extending Resolution of Fault Slip With Geodetic Networks Through Optimal Network Design

    Science.gov (United States)

    Sathiakumar, Sharadha; Barbot, Sylvain Denis; Agram, Piyush

    2017-12-01

    Geodetic networks consisting of high precision and high rate Global Navigation Satellite Systems (GNSS) stations continuously monitor seismically active regions of the world. These networks measure surface displacements and the amount of geodetic strain accumulated in the region and give insight into the seismic potential. SuGar (Sumatra GPS Array) in Sumatra, GEONET (GNSS Earth Observation Network System) in Japan, and PBO (Plate Boundary Observatory) in California are some examples of established networks around the world that are constantly expanding with the addition of new stations to improve the quality of measurements. However, installing new stations to existing networks is tedious and expensive. Therefore, it is important to choose suitable locations for new stations to increase the precision obtained in measuring the geophysical parameters of interest. Here we describe a methodology to design optimal geodetic networks that augment the existing system and use it to investigate seismo-tectonics at convergent and transform boundaries considering land-based and seafloor geodesy. The proposed network design optimization would be pivotal to better understand seismic and tsunami hazards around the world. Land-based and seafloor networks can monitor fault slip around subduction zones with significant resolution, but transform faults are more challenging to monitor due to their near-vertical geometry.

  14. Structural control on the Tohoku earthquake rupture process investigated by 3D FEM, tsunami and geodetic data.

    Science.gov (United States)

    Romano, F; Trasatti, E; Lorito, S; Piromallo, C; Piatanesi, A; Ito, Y; Zhao, D; Hirata, K; Lanucara, P; Cocco, M

    2014-07-09

    The 2011 Tohoku earthquake (Mw = 9.1) highlighted previously unobserved features for megathrust events, such as the large slip in a relatively limited area and the shallow rupture propagation. We use a Finite Element Model (FEM), taking into account the 3D geometrical and structural complexities up to the trench zone, and perform a joint inversion of tsunami and geodetic data to retrieve the earthquake slip distribution. We obtain a close spatial correlation between the main deep slip patch and the local seismic velocity anomalies, and large shallow slip extending also to the North coherently with a seismically observed low-frequency radiation. These observations suggest that the friction controlled the rupture, initially confining the deeper rupture and then driving its propagation up to the trench, where it spreads laterally. These findings are relevant to earthquake and tsunami hazard assessment because they may help to detect regions likely prone to rupture along the megathrust, and to constrain the probability of high slip near the trench. Our estimate of ~40 m slip value around the JFAST (Japan Trench Fast Drilling Project) drilling zone contributes to constrain the dynamic shear stress and friction coefficient of the fault obtained by temperature measurements to ~0.68 MPa and ~0.10, respectively.

  15. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  16. Glacier Mass Changes of Lake-Terminating Grey and Tyndall Glaciers at the Southern Patagonia Icefield Derived From Geodetic Observations and Energy and Mass Balance Modeling

    Directory of Open Access Journals (Sweden)

    Stephanie S. Weidemann

    2018-06-01

    Full Text Available In this study we demonstrate how energy and mass fluxes vary in space and time for Grey and Tyndall glaciers at the Southern Patagonia Icefield (SPI. Despite the overall glacier retreat of most Patagonian glaciers, a recent increase in mass loss has been observed, but individual glaciers respond differently in terms of spatial and temporal changes. In this context, the detailed investigation of the effect of mass balance processes on recent glacier response to climate forcing still needs refinement. We therefore quantify surface energy-fluxes and climatic mass balance of the two neighboring glaciers, Grey and Tyndall. The COupled Snow and Ice energy and MAss balance model COSIMA is applied to assess recent surface energy and climatic mass balance variability with a high temporal and spatial resolution for a 16-year period between April 2000 and March 2016. The model is driven by downscaled 6-hourly atmospheric data derived from ERA-Interim reanalysis and MODIS/Terra Snow Cover and validated against ablation measurements made in single years. High resolution precipitation fields are determined by using an analytical orographic precipitation model. Frontal ablation is estimated as residual of climatic mass balance and geodetic mass balance derived from TanDEM-X/SRTM between 2000 and 2014. We simulate a positive glacier-wide mean annual climatic mass balance of +1.02 ± 0.52 m w.e. a−1 for Grey Glacier and of +0.68 ± 0.54 m w.e. a−1 for Tyndall Glacier between 2000 and 2014. Climatic mass balance results show a high year to year variability. Comparing climatic mass balance results with previous studies underlines the high uncertainty in climatic mass balance modeling with respect to accumulation on the SPI. Due to the lack of observations accumulation estimates differ from previous studies based on the methodological approaches. Mean annual ice loss by frontal ablation is estimated to be 2.07 ± 0.70 m w.e. a−1 for Grey Glacier and 3.26 ± 0

  17. Need for denser geodetic network to get real constrain on the fault behavior along the Main Marmara Sea segments of the NAF, toward an optimized GPS network.

    Science.gov (United States)

    Klein, E.; Masson, F.; Duputel, Z.; Yavasoglu, H.; Agram, P. S.

    2016-12-01

    Over the last two decades, the densification of GPS networks and the development of new radar satellites offered an unprecedented opportunity to study crustal deformation due to faulting. Yet, submarine strike slip fault segments remain a major issue, especially when the landscape appears unfavorable to the use of SAR measurements. It is the case of the North Anatolian fault segments located in the Main Marmara Sea, that remain unbroken ever since the Mw7.4 earthquake of Izmit in 1999, which ended a eastward migrating seismic sequence of Mw > 7 earthquakes. Located directly offshore Istanbul, evaluation of seismic hazard appears capital. But a strong controversy remains over whether these segments are accumulating strain and are likely to experience a major earthquake, or are creeping, resulting both from the simplicity of current geodetic models and the scarcity of geodetic data. We indeed show that 2D infinite fault models cannot account for the complexity of the Marmara fault segments. But current geodetic data in the western region of Istanbul are also insufficient to invert for the coupling using a 3D geometry of the fault. Therefore, we implement a global optimization procedure aiming at identifying the most favorable distribution of GPS stations to explore the strain accumulation. We present here the results of this procedure that allows to determine both the optimal number and location of the new stations. We show that a denser terrestrial survey network can indeed locally improve the resolution on the shallower part of the fault, even more efficiently with permanent stations. But data closer from the fault, only possible by submarine measurements, remain necessary to properly constrain the fault behavior and its potential along strike coupling variations.

  18. A new velocity field for Africa from combined GPS and DORIS space geodetic Solutions: Contribution to the definition of the African reference frame (AFREF)

    Science.gov (United States)

    Saria, E.; Calais, E.; Altamimi, Z.; Willis, P.; Farah, H.

    2013-04-01

    We analyzed 16 years of GPS and 17 years of Doppler orbitography and radiopositioning integrated by satellite (DORIS) data at continuously operating geodetic sites in Africa and surroundings to describe the present-day kinematics of the Nubian and Somalian plates and constrain relative motions across the East African Rift. The resulting velocity field describes horizontal and vertical motion at 133 GPS sites and 9 DORIS sites. Horizontal velocities at sites located on stable Nubia fit a single plate model with a weighted root mean square residual of 0.6 mm/yr (maximum residual 1 mm/yr), an upper bound for plate-wide motions and for regional-scale deformation in the seismically active southern Africa and Cameroon volcanic line. We confirm significant southward motion ( ˜ 1.5 mm/yr) in Morocco with respect to Nubia, consistent with earlier findings. We propose an updated angular velocity for the divergence between Nubia and Somalia, which provides the kinematic boundary conditions to rifting in East Africa. We update a plate motion model for the East African Rift and revise the counterclockwise rotation of the Victoria plate and clockwise rotation of the Rovuma plate with respect to Nubia. Vertical velocities range from - 2 to +2 mm/yr, close to their uncertainties, with no clear geographic pattern. This study provides the first continent-wide position/velocity solution for Africa, expressed in International Terrestrial Reference Frame (ITRF2008), a contribution to the upcoming African Reference Frame (AFREF). Except for a few regions, the African continent remains largely under-sampled by continuous space geodetic data. Efforts are needed to augment the geodetic infrastructure and openly share existing data sets so that the objectives of AFREF can be fully reached.

  19. Rupture history of the 2008 Mw 7.9 Wenchuan, China, earthquake: Evaluation of separate and joint inversions of geodetic, teleseismic, and strong-motion data

    Science.gov (United States)

    Hartzell, Stephen; Mendoza, Carlos; Ramírez-Guzmán, Leonardo; Zeng, Yuesha; Mooney, Walter

    2013-01-01

    An extensive data set of teleseismic and strong-motion waveforms and geodetic offsets is used to study the rupture history of the 2008 Wenchuan, China, earthquake. A linear multiple-time-window approach is used to parameterize the rupture. Because of the complexity of the Wenchuan faulting, three separate planes are used to represent the rupturing surfaces. This earthquake clearly demonstrates the strengths and limitations of geodetic, teleseismic, and strong-motion data sets. Geodetic data (static offsets) are valuable for determining the distribution of shallower slip but are insensitive to deeper faulting and reveal nothing about the timing of slip. Teleseismic data in the distance range 30°–90° generally involve no modeling difficulties because of simple ray paths and can distinguish shallow from deep slip. Teleseismic data, however, cannot distinguish between different slip scenarios when multiple fault planes are involved because steep takeoff angles lead to ambiguity in timing. Local strong-motion data, on the other hand, are ideal for determining the direction of rupture from directivity but can easily be over modeled with inaccurate Green’s functions, leading to misinterpretation of the slip distribution. We show that all three data sets are required to give an accurate description of the Wenchuan rupture. The moment is estimated to be approximately 1.0 × 1021 N · m with the slip characterized by multiple large patches with slips up to 10 m. Rupture initiates on the southern end of the Pengguan fault and proceeds unilaterally to the northeast. Upon reaching the cross-cutting Xiaoyudong fault, rupture of the adjacent Beichuan fault starts at this juncture and proceeds bilaterally to the northeast and southwest.

  20. High-Precision Global Geodetic Systems: Revolution And Revelation In Fluid And 'Solid' Earth Tracking (Invited)

    Science.gov (United States)

    Minster, J. H.; Altamimi, Z.; Blewitt, G.; Carter, W. E.; Cazenave, A. A.; Davis, J. L.; Dragert, H.; Feary, D. A.; Herring, T.; Larson, K. M.; Ries, J. C.; Sandwell, D. T.; Wahr, J. M.

    2009-12-01

    Over the past half-century, space geodetic technologies have changed profoundly the way we look at the planet, not only in the matter of details and accuracy, but also in the matter of how the entire planet changes with time, even on “human” time scales. The advent of space geodesy has provided exquisite images of the ever-changing land and ocean topography and global gravity field of the planet. We now enjoy an International Terrestrial Reference System with a time-dependent geocenter position accurate to a few millimeters. We can image small and large tectonic deformations of the surface before, during, and after earthquakes and volcanic eruptions. We measure both the past subtle changes as well as the recent dramatic changes in the ice sheets, and track global and regional sea-level change to a precision of a millimeter per year or better. The remarkable achievements of Earth observing missions over the past two decades, and the success of future international missions described in the Decadal Survey depend both implicitly and explicitly on the continued availability and enhancement of a reliable and resilient global infrastructure for precise geodesy, and on ongoing advances in geodetic science that are linked to it. This allows us to deal with global scientific, technological and social issues such as climate change and natural hazards, but the impact of the global precise geodetic infrastructure also permeates our everyday lives. Nowadays drivers, aviators, and sailors can determine their positions inexpensively to meter precision in real time, anywhere on the planet. In the foreseeable future, not only will we be able to know a vehicle’s position to centimeter accuracy in real time, but also to control that position, and thus introduce autonomous navigation systems for many tasks which are beyond the reach of “manual” navigation capabilities. This vision will only be realized with sustained international support of the precise global geodetic

  1. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  2. GBIS (Geodetic Bayesian Inversion Software): Rapid Inversion of InSAR and GNSS Data to Estimate Surface Deformation Source Parameters and Uncertainties

    Science.gov (United States)

    Bagnardi, M.; Hooper, A. J.

    2017-12-01

    Inversions of geodetic observational data, such as Interferometric Synthetic Aperture Radar (InSAR) and Global Navigation Satellite System (GNSS) measurements, are often performed to obtain information about the source of surface displacements. Inverse problem theory has been applied to study magmatic processes, the earthquake cycle, and other phenomena that cause deformation of the Earth's interior and of its surface. Together with increasing improvements in data resolution, both spatial and temporal, new satellite missions (e.g., European Commission's Sentinel-1 satellites) are providing the unprecedented opportunity to access space-geodetic data within hours from their acquisition. To truly take advantage of these opportunities we must become able to interpret geodetic data in a rapid and robust manner. Here we present the open-source Geodetic Bayesian Inversion Software (GBIS; available for download at http://comet.nerc.ac.uk/gbis). GBIS is written in Matlab and offers a series of user-friendly and interactive pre- and post-processing tools. For example, an interactive function has been developed to estimate the characteristics of noise in InSAR data by calculating the experimental semi-variogram. The inversion software uses a Markov-chain Monte Carlo algorithm, incorporating the Metropolis-Hastings algorithm with adaptive step size, to efficiently sample the posterior probability distribution of the different source parameters. The probabilistic Bayesian approach allows the user to retrieve estimates of the optimal (best-fitting) deformation source parameters together with the associated uncertainties produced by errors in the data (and by scaling, errors in the model). The current version of GBIS (V1.0) includes fast analytical forward models for magmatic sources of different geometry (e.g., point source, finite spherical source, prolate spheroid source, penny-shaped sill-like source, and dipping-dike with uniform opening) and for dipping faults with uniform

  3. 4-D Visualization of Seismic and Geodetic Data of the Big Island of Hawai'i

    Science.gov (United States)

    Burstein, J. A.; Smith-Konter, B. R.; Aryal, A.

    2017-12-01

    For decades Hawai'i has served as a natural laboratory for studying complex interactions between magmatic and seismic processes. Investigating characteristics of these processes, as well as the crustal response to major Hawaiian earthquakes, requires a synthesis of seismic and geodetic data and models. Here, we present a 4-D visualization of the Big Island of Hawai'i that investigates geospatial and temporal relationships of seismicity, seismic velocity structure, and GPS crustal motions to known volcanic and seismically active features. Using the QPS Fledermaus visualization package, we compile 90 m resolution topographic data from NASA's Shuttle Radar Topography Mission (SRTM) and 50 m resolution bathymetric data from the Hawaiian Mapping Research Group (HMRG) with a high-precision earthquake catalog of more than 130,000 events from 1992-2009 [Matoza et al., 2013] and a 3-D seismic velocity model of Hawai'i [Lin et al., 2014] based on seismic data from the Hawaiian Volcano Observatory (HVO). Long-term crustal motion vectors are integrated into the visualization from HVO GPS time-series data. These interactive data sets reveal well-defined seismic structure near the summit areas of Mauna Loa and Kilauea volcanoes, where high Vp and high Vp/Vs anomalies at 5-12 km depth, as well as clusters of low magnitude (M data are also used to help identify seismic clusters associated with the steady crustal detachment of the south flank of Kilauea's East Rift Zone. We also investigate the fault geometry of the 2006 M6.7 Kiholo Bay earthquake event by analyzing elastic dislocation deformation modeling results [Okada, 1985] and HVO GPS and seismic data of this event. We demonstrate the 3-D fault mechanisms of the Kiholo Bay main shock as a combination of strike-slip and dip-slip components (net slip 0.55 m) delineating a 30 km east-west striking, southward-dipping fault plane, occurring at 39 km depth. This visualization serves as a resource for advancing scientific analyses of

  4. Geodetic Insights into the Earthquake Cycle in a Fold and Thrust Belt

    Science.gov (United States)

    Ingleby, T. F.; Wright, T. J.; Butterworth, V.; Weiss, J. R.; Elliott, J.

    2017-12-01

    Geodetic measurements are often sparse in time (e.g. individual interferograms) and/or space (e.g. GNSS stations), adversely affecting our ability to capture the spatiotemporal detail required to study the earthquake cycle in complex tectonic systems such as subaerial fold and thrust belts. In an effort to overcome these limitations we combine 3 generations of SAR satellite data (ERS 1/2, Envisat & Sentinel-1a/b) to obtain a 25 year, high-resolution surface displacement time series over the frontal portion of an active fold and thrust belt near Quetta, Pakistan where a Mw 7.1 earthquake doublet occurred in 1997. With these data we capture a significant portion of the seismic cycle including the interseismic, coseismic and postseismic phases. Each satellite time series has been referenced to the first ERS-1 SAR epoch by fitting a ground deformation model to the data. This allows us to separate deformation associated with each phase and to examine their relative roles in accommodating strain and creating topography, and to explore the relationship between the earthquake cycle and critical taper wedge mechanics. Modeling of the coseismic deformation suggests a long, thin rupture with rupture length 7 times greater than rupture width. Rupture was confined to a 20-30 degree north-northeast dipping reverse fault or ramp at depth, which may be connecting two weak decollements at approximately 8 km and 13 km depth. Alternatively, intersections between the coseismic fault plane and pre-existing steeper splay faults underlying folds may have played a significant role in inhibiting rupture, as evidenced by intersection points bordering the rupture. These fault intersections effectively partition the fault system down-dip and enable long, thin ruptures. Postseismic deformation is manifest as uplift across short-wavelength folds at the thrust front, with displacement rates decreasing with time since the earthquake. Broader patterns of postseismic uplift are also observed

  5. Coseismic deformation of the 2001 El Salvador and 2002 Denali fault earthquakes from GPS geodetic measurements

    Science.gov (United States)

    Hreinsdottir, Sigrun

    2005-07-01

    GPS geodetic measurements are used to study two major earthquakes, the 2001 MW 7.7 El Salvador and 2002 MW 7.9 Denali Fault earthquakes. The 2001 MW 7.7 earthquake was a normal fault event in the subducting Cocos plate offshore El Salvador. Coseismic displacements of up to 15 mm were measured at permanent GPS stations in Central America. The GPS data were used to constrain the location of and slip on the normal fault. One month later a MW 6.6 strike-slip earthquake occurred in the overriding Caribbean plate. Coulomb stress changes estimated from the M W 7.7 earthquake suggest that it triggered the MW 6.6 earthquake. Coseismic displacement from the MW 6.6 earthquake, about 40 mm at a GPS station in El Salvador, indicates that the earthquake triggered additional slip on a fault close to the GPS station. The MW 6.6 earthquake further changed the stress field in the overriding Caribbean plate, with triggered seismic activity occurring west and possibly also to the east of the rupture in the days to months following the earthquake. The MW 7.9 Denali Fault earthquake ruptured three faults in the interior of Alaska. It initiated with a thrust motion on the Susitna Glacier fault but then ruptured the Denali and Totschunda faults with predominantly right-lateral strike-slip motion unilaterally from west to east. GPS data measured in the two weeks following the earthquake suggest a complex coseismic rupture along the faults with two main regions of moment release along the Denali fault. A large amount of additional data were collected in the year following the earthquake which greatly improved the resolution on the fault, revealing more details of the slip distribution. We estimate a total moment release of 6.81 x 1020 Nm in the earthquake with a M W 7.2 thrust subevent on Susitna Glacier fault. The slip on the Denali fault is highly variable, with 4 main pulses of moment release. The largest moment pulse corresponds to a MW 7.5 subevent, about 40 km west of the Denali

  6. Second-order design problem in the Ancona geodetic network

    International Nuclear Information System (INIS)

    Baldi, P.; Ferrari, G.; Postpischl, D.; Unguendoli, M.

    1980-01-01

    In this note an examination is made of the control network installed in the Ancona area in 1975 for seismotectonic studies. From an analysis of the network there arises the possibility of achieving a considerable improvement in the results by considering a plan of work derived from the a priori analysis of the covariance matrix and improving the atmospheric data fo the correction of electronic distance measurements, by the use of meteorological balloons. (author)

  7. Volcano-tectonic deformation in the Kivu Region, Central Africa: Results from six years of continuous GNSS observations of the Kivu Geodetic Network (KivuGNet)

    Science.gov (United States)

    Geirsson, Halldor; d'Oreye, Nicolas; Mashagiro, Niche; Syauswa, Muhindo; Celli, Gilles; Kadufu, Benjamin; Smets, Benoît; Kervyn, François

    2017-10-01

    We present an overview of the installation, operation, and initial results of the 15-station KivuGNet (Kivu Geodetic Network) in the Kivu Region, Central Africa. The network serves primarily as a research and monitoring tool for active volcanic, earthquake, and plate boundary processes in the region. Continuous operation of in-situ measurement networks in naturally and politically harsh environments is challenging, but has proven fruitful in this case. During the operation of the network since 2009, KivuGNet has captured: co-eruptive deformation from two eruptions of Nyamulagira (in 2010 and 2011-2012); inter-eruptive deformation, which we interpret as a combination of plate motion across the Western - East Africa Rift, and decreasing deep-seated magma accumulation under the Nyiragongo-Nyamulagira region; co-seismic deformation from the Mw5.8 August 7, 2015 Lwiro earthquake at the western border of Lake Kivu. We hope that this study will serve as a motivation for further implementation of in-situ geodetic networks in under-monitored and under-studied sections of the East African Rift.

  8. Subsequent pregnancy outcome after previous foetal death

    NARCIS (Netherlands)

    Nijkamp, J. W.; Korteweg, F. J.; Holm, J. P.; Timmer, A.; Erwich, J. J. H. M.; van Pampus, M. G.

    Objective: A history of foetal death is a risk factor for complications and foetal death in subsequent pregnancies as most previous risk factors remain present and an underlying cause of death may recur. The purpose of this study was to evaluate subsequent pregnancy outcome after foetal death and to

  9. Combination of coseismic displacement fields: a geodetic perspective

    Directory of Open Access Journals (Sweden)

    Roberto Devoti

    2012-10-01

    Full Text Available This study provides the mathematical framework for the rigorous combination of coseismic offsets observed by a global positioning system (GPS network and investigates the results obtained on the occasion of the recent Emilia earthquakes (Italy. This seismic sequence that affected northern Italy from May 20, 2012, allowed two offset fields to be computed, one with reference to the mainshock (M 5.9, followed by two other M 5.1 events on the same day, and a second with reference to the replicas that occurred on May 29, 2012 (M 5.8, M 5.3 and M 5.2; ISIDe data archive, http://iside.rm.ingv.it. The final displacement field is basically the result of a comparison and validation process with repeated feedback between the different analysis groups at the Istituto Nazionale di Geofisica e Vulcanologia (INGV; National Institute of Geophysics and Volcanology that was established to obtain prompt coseismic displacement solutions, as precise as possible, and in the first days after an event. This is important for early seismic-source evaluation as it represents the most complete and validated dataset at the very early stage of a seismic crisis, and it is also extremely useful in reducing random and systematic errors in the estimated parameters. This study is the result of a cooperative effort that involved different research groups at INGV, with the sharing of all of the collected GPS data. The intention was to compare these results and thus reducing sources of error associated with individual processing strategies, to allow the final combination of the different displacement fields into a single consensus solution. The process assessed the robustness of each single GPS result, thus minimizing erroneous interpretations of individual solutions. […

  10. Rigorous covariance propagation of geoid errors to geodetic MDT estimates

    Science.gov (United States)

    Pail, R.; Albertella, A.; Fecher, T.; Savcenko, R.

    2012-04-01

    The mean dynamic topography (MDT) is defined as the difference between the mean sea surface (MSS) derived from satellite altimetry, averaged over several years, and the static geoid. Assuming geostrophic conditions, from the MDT the ocean surface velocities as important component of global ocean circulation can be derived from it. Due to the availability of GOCE gravity field models, for the very first time MDT can now be derived solely from satellite observations (altimetry and gravity) down to spatial length-scales of 100 km and even below. Global gravity field models, parameterized in terms of spherical harmonic coefficients, are complemented by the full variance-covariance matrix (VCM). Therefore, for the geoid component a realistic statistical error estimate is available, while the error description of the altimetric component is still an open issue and is, if at all, attacked empirically. In this study we make the attempt to perform, based on the full gravity VCM, rigorous error propagation to derived geostrophic surface velocities, thus also considering all correlations. For the definition of the static geoid we use the third release of the time-wise GOCE model, as well as the satellite-only combination model GOCO03S. In detail, we will investigate the velocity errors resulting from the geoid component in dependence of the harmonic degree, and the impact of using/no using covariances on the MDT errors and its correlations. When deriving an MDT, it is spectrally filtered to a certain maximum degree, which is usually driven by the signal content of the geoid model, by applying isotropic or non-isotropic filters. Since this filtering is acting also on the geoid component, the consistent integration of this filter process into the covariance propagation shall be performed, and its impact shall be quantified. The study will be performed for MDT estimates in specific test areas of particular oceanographic interest.

  11. Seismic sources in El Salvador. A geological and geodetic contribution

    Science.gov (United States)

    Alonso-Henar, J.; Martínez-Díaz, J. J.; Benito, B.; Alvarez-Gomez, J. A.; Canora, C.; Capote, R.; Staller, A.; Tectónica Activa, Paleosismicidad y. Riesgos Asociados UCM-910368

    2013-05-01

    El Salvador Fault Zone is a deformation band of 150 km long and 20 km wide within the Salvadorian volcanic arc. This shear band distributes the deformation between main strike-slip faults trending N90°-100°E and around 30 km long, and secondary normal faults trending between N120°E and N170°E. The ESFZ continues westward and is relieved by the Jalpatagua Fault. Eastward ESFZ becomes less clear disappearing at Golfo de Fonseca. The ESFZ deforms and offsets quaternary deposits with a right lateral movement in its main segments. Five segments have been proposed for the whole fault zone, from the Jalpatagua Fault to the Golfo de Fonseca. Paleoseismic studies in the Berlin and San Vicente Segments reveal an important amount of quaternary deformation. In fact, the San Vicente Segment was the source of the February 13, 2001 destructive earthquake. In this work we propose 18 capable seismic sources within El Salvador. The slip rate of each source has been obtained through out the combination of GPS data and paleoseismic data when it has been possible. We also have calculated maximum theoretical intensities produced by the maximum earthquakes related with each fault. We have taken into account several scenarios considering different possible surface rupture lengths up to 50 km and Mw 7.6 in some of the strike slip faults within ESFZ.

  12. Deformation offshore Northern Chile monitored by a seafloor geodetic network (GeoSEA)

    Science.gov (United States)

    Hannemann, Katrin; Lange, Dietrich; Kopp, Heidrun; Petersen, Florian; Contreras-Reyes, Eduardo

    2017-04-01

    The Nazca-South American plate boundary around 21°S has last ruptured in an earthquake in 1877 and was identified as a seismic gap prior to the 2014 Iquique earthquake (Mw=8.1). The southern portion of this segment is still unbroken. The geodetic monitoring of the Chilean subduction zone is crucial to understand the deformation processes in this area. Most geodetic measurements rely on GPS and are therefore limited to onshore campaigns. In December 2015, we installed the GeoSEA (Geodetic Earthquake Observatory on the SEAfloor) array around 21°S of the Nazca-South American plate boundary with RV SONNE to extend the geodetic observations to the offshore areas. The GeoSEA array consists of autonomous acoustic seafloor transponders mounted on 4 m high tripods. These transponders are able to continuously measure the two-way travel time of acoustic signals between station pairs (baselines) and the properties of the sea water (sound speed, temperature and pressure) at each transponder. These measurements are used to retrieve the distances between the transponders and give insights into the deformation of the seafloor. At the Chilean subduction zone, we installed in total 23 transponders in 3 subarrays with interstation distances of up to 2500 m. On the middle continental slope in 2300 m water depth, an array consisting of 8 transponders measures across crustal faults seen in AUV mapping. A second array of 5 stations located on the outer rise monitors extension across normal plate-bending faults. The deepest deployment in 5000 m water depth located on the lower continental slope with 10 stations is designed to measure diffuse strain build-up. The transponders are intended to monitor the seafloor deformation for 3.5 years. In November 2016 during a cruise of RV Langseth, the first 11 months of data were successfully uploaded via an acoustic modem. Furthermore, an additional component of the network, GeoSURF, a self-steering autonomous vehicle (wave glider), was

  13. Geodetic slip solutions for the Mw=7.4 Champerico (Guatemala) subduction earthquake of November 7 2012

    Science.gov (United States)

    Ellis, Andria; DeMets, Charles; Briole, Pierre; Molina, Enrique; Flores, Omar; Rivera, Jeffrey; Lasserre, Cécile; Lyon-Caen, Hélène; Lord, Neal

    2014-05-01

    As the first large subduction thrust earthquake off the coast of western Guatemala in the past 50 years, the 7 November 2012 Mw=7.4 earthquake offers the first opportunity for a geodetic study of coseismic and postseismic behavior for a segment of the Middle America trench where frictional coupling makes a transition from weak coupling off the coast of El Salvador to strong coupling in southern Mexico. Processing of continuous GPS measurements at 19 stations in Guatemala, El Salvador, and southern Mexico, and at 7 campaign points in Guatemala defines a highly consistent pattern of coseismic offsets during the earthquake, ranging from 47±5 mm of SW movement just inland from the earthquake epicenter to a few mm at sites located in northern Guatemala. Inversions of these offsets to find their best-fitting fault-slip solution in an elastic half space give a geodetic earthquake moment ranging between 0.75 and 1.1 x 1020 Nm, slightly smaller than the seismic estimates that range between 1.2 and 1.45 x 1020 Nm. Slip inversion using a constant slip model, assuming 293° and 29° for the fault azimuth and dip angle, indicates a nearly reverse slip of 2.8 m (rake 78°) on a fault plane 42 km-long and 20 km-wide, centered at 26 km depth. A variable slip inversion indicates that slip concentrated above depths of 40 km may have extended updip to the trench and reached a maximum of only 0.8 m, less than one-sixth the maximum slip indicated by a recent slip solution (5.3 m) obtained from waveform inversion of seismological data. Detailed model comparisons will be discussed. Transient postseismic displacements have been recorded at the nearby continuous GPS sites with amplitudes reaching 20-25 mm at some stations. The duration of the phenomenon is short: using an exponential-decay model, the estimated decay time is 90 ± 10 days. This postseismic signal is consistent with afterslip along a significantly broader area (+50%) of the subduction interface than ruptured coseismically

  14. Geodetic slip solutions for the Mw = 7.4 Champerico (Guatemala) earthquake of 2012 November 7 and its postseismic deformation

    Science.gov (United States)

    Ellis, Andria P.; DeMets, Charles; Briole, Pierre; Molina, Enrique; Flores, Omar; Rivera, Jeffrey; Lasserre, Cécile; Lyon-Caen, Hélène; Lord, Neal

    2015-05-01

    As the first large subduction thrust earthquake off the coast of western Guatemala in the past several decades, the 2012 November 7 Mw = 7.4 earthquake offers the first opportunity to study coseismic and postseismic behaviour along a segment of the Middle America trench where frictional coupling makes a transition from weak coupling off the coast of El Salvador to strong coupling in southern Mexico. We use measurements at 19 continuous GPS sites in Guatemala, El Salvador and Mexico to estimate the coseismic slip and postseismic deformation of the November 2012 Champerico (Guatemala) earthquake. An inversion of the coseismic offsets, which range up to ˜47 mm at the surface near the epicentre, indicates that up to ˜2 m of coseismic slip occurred on a ˜30 × 30 km rupture area between ˜10 and 30 km depth, which is near the global CMT centroid. The geodetic moment of 13 × 1019 N m and corresponding magnitude of 7.4 both agree well with independent seismological estimates. Transient postseismic deformation that was recorded at 11 GPS sites is attributable to a combination of fault afterslip and viscoelastic flow in the lower crust and/or mantle. Modelling of the viscoelastic deformation suggests that it constituted no more than ˜30 per cent of the short-term postseismic deformation. GPS observations that extend six months after the earthquake are well fit by a model in which most afterslip occurred at the same depth or directly downdip from the rupture zone and released energy equivalent to no more than ˜20 per cent of the coseismic moment. An independent seismological slip solution that features more highly concentrated coseismic slip than our own fits the GPS offsets well if its slip centroid is translated ˜50 km to the west to a position close to our slip centroid. The geodetic and seismologic slip solutions thus suggest bounds of 2-7 m for the peak slip along a region of the interface no larger than 30 × 30 km.

  15. Wavelet based comparison of high frequency oscillations in the geodetic and fluid excitation functions of polar motion

    Science.gov (United States)

    Kosek, W.; Popinski, W.; Niedzielski, T.

    2011-10-01

    It has been already shown that short period oscillations in polar motion, with periods less than 100 days, are very chaotic and are responsible for increase in short-term prediction errors of pole coordinates data. The wavelet technique enables to compare the geodetic and fluid excitation functions in the high frequency band in many different ways, e.g. by looking at the semblance function. The waveletbased semblance filtering enables determination the common signal in both geodetic and fluid excitation time series. In this paper the considered fluid excitation functions consist of the atmospheric, oceanic and land hydrology excitation functions from ECMWF atmospheric data produced by IERS Associated Product Centre Deutsches GeoForschungsZentrum, Potsdam. The geodetic excitation functions have been computed from the combined IERS pole coordinates data.

  16. Uncertainty assessment in geodetic network adjustment by combining GUM and Monte-Carlo-simulations

    Science.gov (United States)

    Niemeier, Wolfgang; Tengen, Dieter

    2017-06-01

    In this article first ideas are presented to extend the classical concept of geodetic network adjustment by introducing a new method for uncertainty assessment as two-step analysis. In the first step the raw data and possible influencing factors are analyzed using uncertainty modeling according to GUM (Guidelines to the Expression of Uncertainty in Measurements). This approach is well established in metrology, but rarely adapted within Geodesy. The second step consists of Monte-Carlo-Simulations (MC-simulations) for the complete processing chain from raw input data and pre-processing to adjustment computations and quality assessment. To perform these simulations, possible realizations of raw data and the influencing factors are generated, using probability distributions for all variables and the established concept of pseudo-random number generators. Final result is a point cloud which represents the uncertainty of the estimated coordinates; a confidence region can be assigned to these point clouds, as well. This concept may replace the common concept of variance propagation and the quality assessment of adjustment parameters by using their covariance matrix. It allows a new way for uncertainty assessment in accordance with the GUM concept for uncertainty modelling and propagation. As practical example the local tie network in "Metsähovi Fundamental Station", Finland is used, where classical geodetic observations are combined with GNSS data.

  17. Plate Motion and Crustal Deformation Estimated with Geodetic Data from the Global Positioning System

    Science.gov (United States)

    Argus, Donald F.; Heflin, Michael B.

    1995-01-01

    We use geodetic data taken over four years with the Global Positioning System (GPS) to estimate: (1) motion between six major plates and (2) motion relative to these plates of ten sites in plate boundary zones. The degree of consistency between geodetic velocities and rigid plates requires the (one-dimensional) standard errors in horizontal velocities to be approx. 2 mm/yr. Each of the 15 angular velocities describing motion between plate pairs that we estimate with GPS differs insignificantly from the corresponding angular velocity in global plate motion model NUVEL-1A, which averages motion over the past 3 m.y. The motion of the Pacific plate relative to both the Eurasian and North American plates is observed to be faster than predicted by NUVEL-1A, supporting the inference from Very Long B ase- line Interferometry (VLBI) that motion of the Pacific plate has speed up over the past few m.y. The Eurasia-North America pole of rotation is estimated to be north of NUVEL-1A, consistent with the independent hypothesis that the pole has recently migrated northward across northeast Asia to near the Lena River delta. Victoria, which lies above the main thrust at the Cascadia subduction zone, moves relative to the interior of the overriding plate at 30% of the velocity of the subducting plate, reinforcing the conclusion that the thrust there is locked beneath the continental shelf and slope.

  18. Application of Geodetic VLBI Data to Obtaining Long-Term Light Curves for Astrophysics

    Science.gov (United States)

    Kijima, Masachika

    2010-01-01

    The long-term light curve is important to research on binary black holes and disk instability in AGNs. The light curves have been drawn mainly using single dish data provided by the University of Michigan Radio Observatory and the Metsahovi Radio Observatory. Hence, thus far, we have to research on limited sources. I attempt to draw light curves using VLBI data for those sources that have not been monitored by any observatories with single dish. I developed software, analyzed all geodetic VLBI data available at the IVS Data Centers, and drew the light curves at 8 GHz. In this report, I show the tentative results for two AGNs. I compared two light curves of 4C39.25, which were drawn based on single dish data and on VLBI data. I confirmed that the two light curves were consistent. Furthermore, I succeeded in drawing the light curve of 0454-234 with VLBI data, which has not been monitored by any observatory with single dish. In this report, I suggest that the geodetic VLBI archive data is useful to obtain the long-term light curves at radio bands for astrophysics.

  19. Facilitating open global data use in earthquake source modelling to improve geodetic and seismological approaches

    Science.gov (United States)

    Sudhaus, Henriette; Heimann, Sebastian; Steinberg, Andreas; Isken, Marius; Vasyura-Bathke, Hannes

    2017-04-01

    In the last few years impressive achievements have been made in improving inferences about earthquake sources by using InSAR (Interferometric Synthetic Aperture Radar) data. Several factors aided these developments. The open data basis of earthquake observations has expanded vastly with the two powerful Sentinel-1 SAR sensors up in space. Increasing computer power allows processing of large data sets for more detailed source models. Moreover, data inversion approaches for earthquake source inferences are becoming more advanced. By now data error propagation is widely implemented and the estimation of model uncertainties is a regular feature of reported optimum earthquake source models. Also, more regularly InSAR-derived surface displacements and seismological waveforms are combined, which requires finite rupture models instead of point-source approximations and layered medium models instead of homogeneous half-spaces. In other words the disciplinary differences in geodetic and seismological earthquake source modelling shrink towards common source-medium descriptions and a source near-field/far-field data point of view. We explore and facilitate the combination of InSAR-derived near-field static surface displacement maps and dynamic far-field seismological waveform data for global earthquake source inferences. We join in the community efforts with the particular goal to improve crustal earthquake source inferences in generally not well instrumented areas, where often only the global backbone observations of earthquakes are available provided by seismological broadband sensor networks and, since recently, by Sentinel-1 SAR acquisitions. We present our work on modelling standards for the combination of static and dynamic surface displacements in the source's near-field and far-field, e.g. on data and prediction error estimations as well as model uncertainty estimation. Rectangular dislocations and moment-tensor point sources are exchanged by simple planar finite

  20. Columnar modelling of nucleation burst evolution in the convective boundary layer – first results from a feasibility study Part IV: A compilation of previous observations for valuation of simulation results from a columnar modelling study

    Directory of Open Access Journals (Sweden)

    O. Hellmuth

    2006-01-01

    according to the parameterisation of the collision-controlled binary nucleation rate proposed by Weber et al. (1996, H2O vapour does not explicitly affect the particle formation. Since the H2SO4 concentration is overpredicted in the simulations presented in Paper III, the nucleation rates are too high compared to previous estimations. Therefore, the results are not directly comparable to measurements. Especially NPF events, where organics are suspected to play a key role, such as those observed at the boreal forest station in Hyytiälä (Southern Finland or at Hohenpeissenberg (mountain site in Southern Germany, can not be explained by employing simple sulphur/ammonia chemistry. However, some valuable hints regarding the role of CBL turbulence in NPF can be obtained. In the literature a number of observations on the link between turbulence and NPF can be found, whose burst patterns support a strong contribution of CBL turbulence to the NPF burst evolution simulated here. Observations, that do not correspond to the scenarios are discussed with respect to possible reasons for the differences between model and observation. The model simulations support some state-of-the-art hypotheses on the contribution of CBL turbulence to NPF. Considering the application of box models, the present study shows, that CBL turbulence, not explicitly considered in such models, can strongly affect the spatio-temporal NPF burst evolution. The columnar high-order model presented here is a helpful tool to elucidate gas-aerosol-turbulence interactions, especially the genesis of NPF bursts in the CBL. An advanced description of the cluster formation and condensation growth is required as well as a comprehensive verification/validation study using observed high-order moments. Further scenario simulations remain to be performed.

  1. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    Energy Technology Data Exchange (ETDEWEB)

    Saitoh, Jun-Ichi, E-mail: junsaito@sannet.ne.jp [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Sakai, Hiroshi; Kurimoto, Futoshi [Division of Respiratory Disease, Saitama Cancer Center, Saitama (Japan); Kato, Shingo [Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Shibuya, Kei [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma (Japan)

    2012-04-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m{sup 2}, and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade {>=}3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade {>=}3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  2. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    International Nuclear Information System (INIS)

    Saitoh, Jun-Ichi; Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro; Sakai, Hiroshi; Kurimoto, Futoshi; Kato, Shingo; Shibuya, Kei

    2012-01-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m 2 , and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade ≥3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade ≥3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  3. Subsequent childbirth after a previous traumatic birth.

    Science.gov (United States)

    Beck, Cheryl Tatano; Watson, Sue

    2010-01-01

    Nine percent of new mothers in the United States who participated in the Listening to Mothers II Postpartum Survey screened positive for meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for posttraumatic stress disorder after childbirth. Women who have had a traumatic birth experience report fewer subsequent children and a longer length of time before their second baby. Childbirth-related posttraumatic stress disorder impacts couples' physical relationship, communication, conflict, emotions, and bonding with their children. The purpose of this study was to describe the meaning of women's experiences of a subsequent childbirth after a previous traumatic birth. Phenomenology was the research design used. An international sample of 35 women participated in this Internet study. Women were asked, "Please describe in as much detail as you can remember your subsequent pregnancy, labor, and delivery following your previous traumatic birth." Colaizzi's phenomenological data analysis approach was used to analyze the stories of the 35 women. Data analysis yielded four themes: (a) riding the turbulent wave of panic during pregnancy; (b) strategizing: attempts to reclaim their body and complete the journey to motherhood; (c) bringing reverence to the birthing process and empowering women; and (d) still elusive: the longed-for healing birth experience. Subsequent childbirth after a previous birth trauma has the potential to either heal or retraumatize women. During pregnancy, women need permission and encouragement to grieve their prior traumatic births to help remove the burden of their invisible pain.

  4. Improving deformation models by discounting transient signals in geodetic data: 2. Geodetic data, stress directions, and long-term strain rates in Italy

    Science.gov (United States)

    Carafa, Michele M. C.; Bird, Peter

    2016-07-01

    The lithosphere of Italy is exposed to a number of different short-term strain transients, including but not limited to landslides, postseismic relaxation, and volcanic inflation/deflation. These transients affect GPS velocities and complicate the assessment of the long-term tectonic component of the surface deformation. In a companion paper we present a method for anticipating the principal patterns of nontectonic, short-term strains and building this information into the covariance matrix of the geodetic velocities. In this work we apply this method to Italian GPS velocities to build an augmented covariance matrix that characterizes all expected discrepancies between short- and long-term velocities. We find that formal uncertainties usually reported for GPS measurements are smaller than the variability of the same benchmarks across a geologic time span. Furthermore, we include in our modeling the azimuths of most compressive horizontal principal stresses (SHmax) because GPS data cannot resolve the active kinematics of coastal and offshore areas. We find that the final tectonic model can be made relatively insensitive to short-term interfering processes if the augmented covariance matrix and SHmax data records are used in the objective function. This results in a preferred neotectonic model that is also in closer agreement with independent geologic and seismological constraints and has the advantage of reducing short-term biases in forecasts of long-term seismicity.

  5. Geodetic Imaging for Rapid Assessment of Earthquakes: Airborne Laser Scanning (ALS)

    Science.gov (United States)

    Carter, W. E.; Shrestha, R. L.; Glennie, C. L.; Sartori, M.; Fernandez-Diaz, J.; National CenterAirborne Laser Mapping Operational Center

    2010-12-01

    To the residents of an area struck by a strong earthquake quantitative information on damage to the infrastructure, and its attendant impact on relief and recovery efforts, is urgent and of primary concern. To earth scientists a strong earthquake offers an opportunity to learn more about earthquake mechanisms, and to compare their models with the real world, in hopes of one day being able to accurately predict the precise locations, magnitudes, and times of large (and potentially disastrous) earthquakes. Airborne laser scanning (also referred to as airborne LiDAR or Airborne Laser Swath Mapping) is particularly well suited for rapid assessment of earthquakes, both for immediately estimating the damage to infrastructure and for providing information for the scientific study of earthquakes. ALS observations collected at low altitude (500—1000m) from a relatively slow (70—100m/sec) aircraft can provide dense (5—15 points/m2) sets of surface features (buildings, vegetation, ground), extending over hundreds of square kilometers with turn around times of several hours to a few days. The actual response time to any given event depends on several factors, including such bureaucratic issues as approval of funds, export license formalities, and clearance to fly over the area to be mapped, and operational factors such as the deployment of the aircraft and ground teams may also take a number of days for remote locations. Of course the need for immediate mapping of earthquake damage generally is not as urgent in remote regions with less infrastructure and few inhabitants. During August 16-19, 2010 the National Center for Airborne Laser Mapping (NCALM) mapped the area affected by the magnitude 7.2 El Mayor-Cucapah Earthquake (Northern Baja California Earthquake), which occurred on April 4, 2010, and was felt throughout southern California, Arizona, Nevada, and Baja California North, Mexico. From initial ground observations the fault rupture appeared to extend 75 km

  6. Characterization of Ground Displacement Sources from Variational Bayesian Independent Component Analysis of Space Geodetic Time Series

    Science.gov (United States)

    Gualandi, Adriano; Serpelloni, Enrico; Elina Belardinelli, Maria; Bonafede, Maurizio; Pezzo, Giuseppe; Tolomei, Cristiano

    2015-04-01

    A critical point in the analysis of ground displacement time series, as those measured by modern space geodetic techniques (primarly continuous GPS/GNSS and InSAR) is the development of data driven methods that allow to discern and characterize the different sources that generate the observed displacements. A widely used multivariate statistical technique is the Principal Component Analysis (PCA), which allows to reduce the dimensionality of the data space maintaining most of the variance of the dataset explained. It reproduces the original data using a limited number of Principal Components, but it also shows some deficiencies, since PCA does not perform well in finding the solution to the so-called Blind Source Separation (BSS) problem. The recovering and separation of the different sources that generate the observed ground deformation is a fundamental task in order to provide a physical meaning to the possible different sources. PCA fails in the BSS problem since it looks for a new Euclidean space where the projected data are uncorrelated. Usually, the uncorrelation condition is not strong enough and it has been proven that the BSS problem can be tackled imposing on the components to be independent. The Independent Component Analysis (ICA) is, in fact, another popular technique adopted to approach this problem, and it can be used in all those fields where PCA is also applied. An ICA approach enables us to explain the displacement time series imposing a fewer number of constraints on the model, and to reveal anomalies in the data such as transient deformation signals. However, the independence condition is not easy to impose, and it is often necessary to introduce some approximations. To work around this problem, we use a variational bayesian ICA (vbICA) method, which models the probability density function (pdf) of each source signal using a mix of Gaussian distributions. This technique allows for more flexibility in the description of the pdf of the sources

  7. Evaluating Commercial and Private Cloud Services for Facility-Scale Geodetic Data Access, Analysis, and Services

    Science.gov (United States)

    Meertens, C. M.; Boler, F. M.; Ertz, D. J.; Mencin, D.; Phillips, D.; Baker, S.

    2017-12-01

    UNAVCO, in its role as a NSF facility for geodetic infrastructure and data, has succeeded for over two decades using on-premises infrastructure, and while the promise of cloud-based infrastructure is well-established, significant questions about suitability of such infrastructure for facility-scale services remain. Primarily through the GeoSciCloud award from NSF EarthCube, UNAVCO is investigating the costs, advantages, and disadvantages of providing its geodetic data and services in the cloud versus using UNAVCO's on-premises infrastructure. (IRIS is a collaborator on the project and is performing its own suite of investigations). In contrast to the 2-3 year time scale for the research cycle, the time scale of operation and planning for NSF facilities is for a minimum of five years and for some services extends to a decade or more. Planning for on-premises infrastructure is deliberate, and migrations typically take months to years to fully implement. Migrations to a cloud environment can only go forward with similar deliberate planning and understanding of all costs and benefits. The EarthCube GeoSciCloud project is intended to address the uncertainties of facility-level operations in the cloud. Investigations are being performed in a commercial cloud environment (Amazon AWS) during the first year of the project and in a private cloud environment (NSF XSEDE resource at the Texas Advanced Computing Center) during the second year. These investigations are expected to illuminate the potential as well as the limitations of running facility scale production services in the cloud. The work includes running parallel equivalent cloud-based services to on premises services and includes: data serving via ftp from a large data store, operation of a metadata database, production scale processing of multiple months of geodetic data, web services delivery of quality checked data and products, large-scale compute services for event post-processing, and serving real time data

  8. Geodezija od Mesopotamije do Globalnog geodetskog opažačkog sistema : Geodesy from Mesopotamie to Global Geodetic Observing System

    Directory of Open Access Journals (Sweden)

    Medžida Mulić

    2015-12-01

    Full Text Available Tokom šest milenijuma postojanja civilizacije na Zemlji, geodetske tehnike su doživjele teško sagledive promjene. Definicija i uloga geodezije su se mijenjale u skladu s tim promijenila. Geodezija (viša je evoluirala od svoje originalne klasične definicije da „proučava kretanja nebeskih tijela, oblik i dimenzije Zemlje“ u „znanost koja osim naprijed rečenog, proučava njene promjene i kompleksne dinamičke procese, koji djeluju unutar Zemlje, na njenoj površini i iznad njene površine, kao i u svemiru koji je okružuje. Rad predstavlja detaljan pregled geodetskih tehnika, instrumenata, katastra i kartografije kod starih civilizacija: Mesopotamije, starog Egipta, antičke Grčke, starog Rima, pa sve do Evropljana, između 17. stoljeća do modernog doba. Posebno su opisani geodetski radovi u Bosni i Hercegovini, od doba osmanlija, austro-ugarskog premjera, do savremenih dostignuća u polju premjera i primjene satelitskih modernih tehnika. Globalni geodetski opažački sistem-GGOS, glavna komponenta Internacionalne asocijacije za geodeziju, kao projekat za buduće generacije geodeta, opisan je na kraju. : During the six millennia of the existence of the civilization on the Earth, surveying techniques have been experienced difficult foreseeable changes. The definition and role of geodesy have been changing accordingly. Geodesy has evolved from its original classic definition that "studying the movements of celestial bodies, the shape and dimensions of the Earth" in the "science which, beside it noted above, studies its changes and complex dynamic processes that ongoing inside the Earth, on the surface, above its surfaces, and evironment. The paper is overview of the geodetic techniques and the surveying instruments, cadastre and cartography in the ancien civilizations: Mesopotamia, ancient Egypt, antic Greece, ancient Rome, to the Europeans, from the 17th century to modern times. A detailed description devoted to surveying and geodetic

  9. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Sachin A Narvekar

    2010-01-01

    Full Text Available Background: Management of repeated implantation failure despite transfer of good-quality embryos still remains a dilemma for ART specialists. Scrapping of endometrium in the nontransfer cycle has been shown to improve the pregnancy rate in the subsequent IVF/ET cycle in recent studies. Aim: The objective of this randomized controlled trial (RCT was to determine whether endometrial injury caused by Pipelle sampling in the nontransfer cycle could improve the probability of pregnancy in the subsequent IVF cycle in patients who had previous failed IVF outcome. Setting: Tertiary assisted conception center. Design: Randomized controlled study. Materials and Methods: 100 eligible patients with previous failed IVF despite transfer of good-quality embryos were randomly allocated to the intervention group and control groups. In the intervention group, Pipelle endometrial sampling was done twice: One in the follicular phase and again in the luteal phase in the cycle preceding the embryo transfer cycle. Outcome Measure: The primary outcome measure was live birth rate. The secondary outcome measures were implantation and clinical pregnancy rates. Results: The live birth rate was significantly higher in the intervention group compared to control group (22.4% and 9.8% P = 0.04. The clinical pregnancy rate in the intervention group was 32.7%, while that in the control group was 13.7%, which was also statistically significant ( P = 0.01. The implantation rate was significantly higher in the intervention group as compared to controls (13.07% vs 7.1% P = 0.04. Conclusions: Endometrial injury in nontransfer cycle improves the live birth rate,clinical pregnancy and implantation rates in the subsequent IVF-ET cycle in patients with previous unsuccessful IVF cycles.

  10. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Directory of Open Access Journals (Sweden)

    Xingsheng Hu

    Full Text Available Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC previously treated with platinum-based chemotherapy.Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day. The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety.From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m and 5.4 months (95%CI 3.1-7.9 m, respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127, diarrhea (12.6%, 16/127 and elevation of transaminase (15.7%, 20/127.In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy.ClinicalTrials.gov NCT02486354.

  11. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Science.gov (United States)

    Hu, Xingsheng; Zhang, Li; Shi, Yuankai; Zhou, Caicun; Liu, Xiaoqing; Wang, Dong; Song, Yong; Li, Qiang; Feng, Jifeng; Qin, Shukui; Xv, Nong; Zhou, Jianying; Zhang, Li; Hu, Chunhong; Zhang, Shucai; Luo, Rongcheng; Wang, Jie; Tan, Fenlai; Wang, Yinxiang; Ding, Lieming; Sun, Yan

    2015-01-01

    Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy. Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day). The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety. From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m) and 5.4 months (95%CI 3.1-7.9 m), respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA) according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127), diarrhea (12.6%, 16/127) and elevation of transaminase (15.7%, 20/127). In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy. ClinicalTrials.gov NCT02486354.

  12. Learned Compact Local Feature Descriptor for Tls-Based Geodetic Monitoring of Natural Outdoor Scenes

    Science.gov (United States)

    Gojcic, Z.; Zhou, C.; Wieser, A.

    2018-05-01

    The advantages of terrestrial laser scanning (TLS) for geodetic monitoring of man-made and natural objects are not yet fully exploited. Herein we address one of the open challenges by proposing feature-based methods for identification of corresponding points in point clouds of two or more epochs. We propose a learned compact feature descriptor tailored for point clouds of natural outdoor scenes obtained using TLS. We evaluate our method both on a benchmark data set and on a specially acquired outdoor dataset resembling a simplified monitoring scenario where we successfully estimate 3D displacement vectors of a rock that has been displaced between the scans. We show that the proposed descriptor has the capacity to generalize to unseen data and achieves state-of-the-art performance while being time efficient at the matching step due the low dimension.

  13. Processing of a geodetic network determined in ETRS-89 with application of different cofactors

    Directory of Open Access Journals (Sweden)

    Slavomír Labant

    2012-12-01

    Full Text Available At present, manufacturers characterize the accuracy of vectors measured by the static method of GNSS technology usingrelationship 5 mm + 1⋅ D ppm . The advantage of the GNSS system over other terrestrial technologies is that it is not affectedby uncertainties in the ground layers of the atmosphere. The paper presents experimental measurement of the 3D geodetic network usingthe technology of global navigation satellite systems, processing and analysis of measurements taken at the Čierny Váh pumping hydropowerstation. Observations were carried out in July 2008. The aim of the paper is to assess parameters used in the model to estimateparameters of the first and second order of the network structures.

  14. Optimization of observation plan based on the stochastic characteristics of the geodetic network

    Directory of Open Access Journals (Sweden)

    Pachelski Wojciech

    2016-06-01

    Full Text Available Optimal design of geodetic network is a basic subject of many engineering projects. An observation plan is a concluding part of the process. Any particular observation within the network has through adjustment a different contribution and impact on values and accuracy characteristics of unknowns. The problem of optimal design can be solved by means of computer simulation. This paper presents a new method of simulation based on sequential estimation of individual observations in a step-by-step manner, by means of the so-called filtering equations. The algorithm aims at satisfying different criteria of accuracy according to various interpretations of the covariance matrix. Apart of them, the optimization criterion is also amount of effort, defined as the minimum number of observations required.

  15. Geodetic measurement of deformation east of the San Andreas Fault in Central California

    Science.gov (United States)

    Sauber, Jeanne; Solomon, Sean C.; Lisowski, Michael

    1988-01-01

    The shear strain rates in the Diablo Range of California have been calculated, and the slip rate along the Calaveras and Paicines faults in Central California have been estimated, on the basis of triangulation and trilateration data from two geodetic networks located between the western edge of the Great Valley and the San Andreas Fault. The orientation of the principal compressive strain predicted from the azimuth of the major structures in the region is N 25 deg E, leading to an average shear strain value that corresponds to a relative shortening rate of 4.5 + or - 2.4 mm/yr. It is inferred that the measured strain is due to compression across the fold of this area. The hypothesized uniform, fault-normal compression within the Coast Ranges is not supported by these results.

  16. Polarised Multiangular Reflectance Measurements Using the Finnish Geodetic Institute Field Goniospectrometer

    Directory of Open Access Journals (Sweden)

    Jouni Peltoniemi

    2009-05-01

    Full Text Available The design, operation, and properties of the Finnish Geodetic Institute Field Goniospectrometer (FIGIFIGO are presented. FIGIFIGO is a portable instrument for the measurement of surface Bidirectional Reflectance Factor (BRF for samples with diameters of 10 – 50 cm. A set of polarising optics enable the measurement of linearly polarised BRF over the full solar spectrum (350 – 2,500 nm. FIGIFIGO is designed mainly for field operation using sunlight, but operation in a laboratory environment is also possible. The acquired BRF have an accuracy of 1 – 5% depending on wavelength, sample properties, and measurement conditions. The angles are registered at accuracies better than 2°. During 2004 – 2008, FIGIFIGO has been used in the measurement of over 150 samples, all around northern Europe. The samples concentrate mostly on boreal forest understorey, snow, urban surfaces, and reflectance calibration surfaces.

  17. A geodetic matched-filter search for slow slip with application to the Mexico subduction zone

    Science.gov (United States)

    Rousset, B.; Campillo, M.; Lasserre, C.; Frank, W.; Cotte, N.; Walpersdorf, A.; Socquet, A.; Kostoglodov, V.

    2017-12-01

    Since the discovery of slow slip events, many methods have been successfully applied to model obvious transient events in geodetic time series, such as the widely used network strain filter. Independent seismological observations of tremors or low frequency earthquakes and repeating earthquakes provide evidence of low amplitude slow deformation but do not always coincide with clear occurrences of transient signals in geodetic time series. Here, we aim to extract the signal corresponding to slow slips hidden in the noise of GPS time series, without using information from independent datasets. We first build a library of synthetic slow slip event templates by assembling a source function with Green's functions for a discretized fault. We then correlate the templates with post-processed GPS time series. Once the events have been detected in time, we estimate their duration T and magnitude Mw by modelling a weighted stack of GPS time series. An analysis of synthetic time series shows that this method is able to resolve the correct timing, location, T and Mw of events larger than Mw 6.0 in the context of the Mexico subduction zone. Applied on a real data set of 29 GPS time series in the Guerrero area from 2005 to 2014, this technique allows us to detect 28 transient events from Mw 6.3 to 7.2 with durations that range from 3 to 39 days. These events have a dominant recurrence time of 40 days and are mainly located at the down dip edges of the Mw > 7.5 SSEs.

  18. A geodetic matched filter search for slow slip with application to the Mexico subduction zone

    Science.gov (United States)

    Rousset, B.; Campillo, M.; Lasserre, C.; Frank, W. B.; Cotte, N.; Walpersdorf, A.; Socquet, A.; Kostoglodov, V.

    2017-12-01

    Since the discovery of slow slip events, many methods have been successfully applied to model obvious transient events in geodetic time series, such as the widely used network strain filter. Independent seismological observations of tremors or low-frequency earthquakes and repeating earthquakes provide evidence of low-amplitude slow deformation but do not always coincide with clear occurrences of transient signals in geodetic time series. Here we aim to extract the signal corresponding to slow slips hidden in the noise of GPS time series, without using information from independent data sets. We first build a library of synthetic slow slip event templates by assembling a source function with Green's functions for a discretized fault. We then correlate the templates with postprocessed GPS time series. Once the events have been detected in time, we estimate their duration T and magnitude Mw by modeling a weighted stack of GPS time series. An analysis of synthetic time series shows that this method is able to resolve the correct timing, location, T, and Mw of events larger than Mw 6 in the context of the Mexico subduction zone. Applied on a real data set of 29 GPS time series in the Guerrero area from 2005 to 2014, this technique allows us to detect 28 transient events from Mw 6.3 to 7.2 with durations that range from 3 to 39 days. These events have a dominant recurrence time of 40 days and are mainly located at the downdip edges of the Mw>7.5 slow slip events.

  19. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

    Science.gov (United States)

    Unfer, Vittorio; Raffone, Emanuela; Rizzo, Piero; Buffo, Silvia

    2011-11-01

    Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality. Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle. After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion. The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

  20. How well can online GPS PPP post-processing services be used to establish geodetic survey control networks?

    Science.gov (United States)

    Ebner, R.; Featherstone, W. E.

    2008-09-01

    Establishing geodetic control networks for subsequent surveys can be a costly business, even when using GPS. Multiple stations should be occupied simultaneously and post-processed with scientific software. However, the free availability of online GPS precise point positioning (PPP) post-processing services offer the opportunity to establish a whole geodetic control network with just one dual-frequency receiver and one field crew. To test this idea, we compared coordinates from a moderate-sized (~550 km by ~440 km) geodetic network of 46 points over part of south-western Western Australia, which were processed both with the Bernese v5 scientific software and with the CSRS (Canadian Spatial Reference System) PPP free online service. After rejection of five stations where the antenna type was not recognised by CSRS, the PPP solutions agreed on average with the Bernese solutions to 3.3 mm in east, 4.8 mm in north and 11.8 mm in height. The average standard deviations of the Bernese solutions were 1.0 mm in east, 1.2 mm in north and 6.2 mm in height, whereas for CSRS they were 3.9 mm in east, 1.9 mm in north and 7.8 mm in height, reflecting the inherently lower precision of PPP. However, at the 99% confidence level, only one CSRS solution was statistically different to the Bernese solution in the north component, due to a data interruption at that site. Nevertheless, PPP can still be used to establish geodetic survey control, albeit with a slightly lower quality because of the larger standard deviations. This approach may be of particular benefit in developing countries or remote regions, where geodetic infrastructure is sparse and would not normally be established without this approach.

  1. Integration of micro-gravity and geodetic data to constrain shallow system mass changes at Krafla Volcano, N Iceland

    Science.gov (United States)

    de Zeeuw-van Dalfsen, Elske; Rymer, Hazel; Williams-Jones, Glyn; Sturkell, Erik; Sigmundsson, Freysteinn

    2006-04-01

    New and previously published micro-gravity data are combined with InSAR data, precise levelling and GPS measurements to produce a model for the processes operating at Krafla volcano, 20 years after its most recent eruption. The data have been divided into two periods: from 1990 to 1995 and from 1996 to 2003 and show that the rate of deflation at Krafla is decaying exponentially. The net micro-gravity change at the centre of the caldera is shown, using the measured free air gradient, to be -85 μGal for the first and -100 μGal for the second period. After consideration of the effects of water extraction by the geothermal power station within the caldera, the net gravity decreases are -73±17 μGal for the first and -65±17 μGal for the second period. These decreases are interpreted in terms of magma drainage. Following a Mogi point source model, we calculate the mass decrease to be ˜2×1010 kg/year reflecting a drainage rate of ˜0.23 m3/s, similar to the ˜0.13 m3/s drainage rate previously found at Askja volcano, N. Iceland. Based on the evidence for deeper magma reservoirs and the similarity between the two volcanic systems, we suggest a pressure-link between Askja and Krafla at deeper levels (at the lower crust or the crust-mantle boundary). After the Krafla fires, co-rifting pressure decrease of a deep source at Krafla stimulated the subsequent inflow of magma, eventually affecting conditions along the plate boundary in N. Iceland, as far away as Askja. We anticipate that the pressure of the deeper reservoir at Krafla will reach a critical value and eventually magma will rise from there to the shallow magma chamber, possibly initiating a new rifting episode. We have demonstrated that by examining micro-gravity and geodetic data, our knowledge of active volcanic systems can be significantly improved.

  2. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.

    Science.gov (United States)

    Chanan-Khan, Asher; Cramer, Paula; Demirkan, Fatih; Fraser, Graeme; Silva, Rodrigo Santucci; Grosicki, Sebastian; Pristupa, Aleksander; Janssens, Ann; Mayer, Jiri; Bartlett, Nancy L; Dilhuydy, Marie-Sarah; Pylypenko, Halyna; Loscertales, Javier; Avigdor, Abraham; Rule, Simon; Villa, Diego; Samoilova, Olga; Panagiotidis, Panagiots; Goy, Andre; Mato, Anthony; Pavlovsky, Miguel A; Karlsson, Claes; Mahler, Michelle; Salman, Mariya; Sun, Steven; Phelps, Charles; Balasubramanian, Sriram; Howes, Angela; Hallek, Michael

    2016-02-01

    Most patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the relapsed or refractory setting. We assessed the efficacy and safety of adding ibrutinib, an oral covalent inhibitor of Bruton's tyrosine kinase (BTK), to bendamustine plus rituximab in patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma. The HELIOS trial was an international, double-blind, placebo-controlled, phase 3 study in adult patients (≥18 years of age) who had active chronic lymphocytic leukaemia or small lymphocytic lymphoma with measurable lymph node disease (>1·5 cm) by CT scan, and had relapsed or refractory disease following one or more previous lines of systemic therapy consisting of at least two cycles of a chemotherapy-containing regimen, an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and adequate bone marrow, liver, and kidney function. Patients with del(17p) were excluded because of known poor response to bendamustine plus rituximab. Patients who had received previous treatment with ibrutinib or other BTK inhibitors, refractory disease or relapse within 24 months with a previous bendamustine-containing regimen, or haemopoietic stem-cell transplant were also excluded. Patients were randomly assigned (1:1) by a web-based system to receive bendamustine plus rituximab given in cycles of 4 weeks' duration (bendamustine: 70 mg/m(2) intravenously on days 2-3 in cycle 1, and days 1-2 in cycles 2-6; rituximab: 375 mg/m(2) on day 1 of cycle 1, and 500 mg/m(2) on day 1 of cycles 2-6 for a maximum of six cycles) with either ibrutinib (420 mg daily orally) or placebo until disease progression or unacceptable toxicity. Patients were stratified according to whether they were refractory to purine analogues and by number of previous lines of therapy. The primary endpoint was independent review committee (IRC)-assessed progression

  3. Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign.

    Science.gov (United States)

    Clemens, Daniel J; Lentino, Anne R; Kapplinger, Jamie D; Ye, Dan; Zhou, Wei; Tester, David J; Ackerman, Michael J

    2018-04-01

    Mutations in the KCNQ1-encoded Kv7.1 potassium channel cause long QT syndrome (LQTS) type 1 (LQT1). It has been suggested that ∼10%-20% of rare LQTS case-derived variants in the literature may have been published erroneously as LQT1-causative mutations and may be "false positives." The purpose of this study was to determine which previously published KCNQ1 case variants are likely false positives. A list of all published, case-derived KCNQ1 missense variants (MVs) was compiled. The occurrence of each MV within the Genome Aggregation Database (gnomAD) was assessed. Eight in silico tools were used to predict each variant's pathogenicity. Case-derived variants that were either (1) too frequently found in gnomAD or (2) absent in gnomAD but predicted to be pathogenic by ≤2 tools were considered potential false positives. Three of these variants were characterized functionally using whole-cell patch clamp technique. Overall, there were 244 KCNQ1 case-derived MVs. Of these, 29 (12%) were seen in ≥10 individuals in gnomAD and are demotable. However, 157 of 244 MVs (64%) were absent in gnomAD. Of these, 7 (4%) were predicted to be pathogenic by ≤2 tools, 3 of which we characterized functionally. There was no significant difference in current density between heterozygous KCNQ1-F127L, -P477L, or -L619M variant-containing channels compared to KCNQ1-WT. This study offers preliminary evidence for the demotion of 32 (13%) previously published LQT1 MVs. Of these, 29 were demoted because of their frequent sighting in gnomAD. Additionally, in silico analysis and in vitro functional studies have facilitated the demotion of 3 ultra-rare MVs (F127L, P477L, L619M). Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  4. Which surgery should be offered for carpal tunnel syndrome in a patient who was previously treated for recurrence on the contralateral side? Preliminary study of 13 patients with the Canaletto® implant.

    Science.gov (United States)

    Illuminati, I; Seigle-Murandi, F; Gouzou, S; Fabacher, T; Facca, S; Hidalgo Diaz, J J; Liverneaux, P

    2017-12-01

    There are no published studies on the management of carpal tunnel syndrome (CTS) patients who have already been operated for recurrent CTS on the contralateral side. The aim of this study was to evaluate 13 patients with CTS who underwent primary release using a Canaletto ® implant. The 13 patients had all been operated for recurrent CTS previously. On the contralateral side, they all had subjective signs, and two of them already had complications. All were operated with the Canaletto ® implant according to Duché's technique, in a mean of 20minutes. After a mean 19.3-month follow-up, paresthesia, pain, and QuickDASH scores were significantly improved, even in one patient who underwent revision at another facility. This preliminary study suggests that use of a Canaletto ® implant as first-line treatment for CTS in patients who already underwent revision surgery on the other side is a simple and safe technique, without worsening of symptoms. These findings should be assessed with a prospective randomized controlled trial. Copyright © 2017 SFCM. Published by Elsevier Masson SAS. All rights reserved.

  5. Continuous terrestrial geodetic monitoring of the 2007 Lava Fan in the Sciara de Fuoco (Stromboli volcano, Italy)

    Science.gov (United States)

    Puglisi, G.; Bonforte, A.; Cantarero, M.; Spata, A.

    2009-12-01

    At the end of the 2002-2003 eruption, a terrestrial monitoring system was set up to regularly measure the movements of benchmarks installed inside the Sciara del Fuoco (hereafter SdF) (Puglisi et al., 2005). This system, named THEODOROS, is based on a remotely controlled robotized Total Station installed near Punta Labronzo, on the northern border of the SdF. The 2007 eruption caused a dramatic change in the operations of THEODOROS. Indeed, the 2007 lava flows destroyed all the benchmarks installed on the northern part of the SdF, leaving only those on its central part. This eruption produced a lava fan at the base of the SdF, due to the rapid cooling of the lava flows on entering the sea. The continuous overlapping of several flows during the eruption built a thick lava body (the fan); it was emplaced on a very steep slope, partially originated during the landslides occurring in December 2002, producing a hazardous condition due to the potential sudden sliding of this fan into the sea. In order to monitor the stability of this lava fan, a new terrestrial geodetic network, was implemented on 6 April 2007, by installing 5 reflectors along a profile crossing the lava body, approximately over the old coastline. Later, in June 2007, 4 more reflectors were installed at higher and lower altitudes with respect to the previous profile, to obtain more information on the overall deformation of the lava body. Measurements were rather noisy during the first months, but a better definition of the reference system strongly improved the quality of the data. The position of the 9 benchmarks over the lava fan enable the areal distribution of the deformation to be drawn. The measurements carried out every 10 minutes allow following their motion with high temporal detail. The data collected since the end of the eruption highlighted a significant downslope motion of the entire lava fan, decreasing from the South to the North, where the body is buttressed by the rocky northern wall of

  6. MOONLIGHT: A NEW LUNAR LASER RANGING RETROREFLECTOR AND THE LUNAR GEODETIC PRECESSION

    Directory of Open Access Journals (Sweden)

    M. Martini

    2013-12-01

    Full Text Available Since the 1970s Lunar Laser Ranging (LLR to the Apollo Cube Corner Retroreflector (CCR arrays (developed by the University of Maryland, UMD supplied almost all significant tests of General Relativity (Alley et al., 1970; Chang et al., 1971; Bender et al.,1973: possible changes in the gravitational constant, gravitational self-energy, weak equivalence principle, geodetic precession, inverse-square force-law. The LNF group, in fact, has just completed a new measurement of the lunar geodetic precession with Apollo array, with accuracy of 9 × 10−3, comparable to the best measurement to date. LLR has also provided significant information on the composition and origin of the moon. This is the only Apollo experiment still in operation. In the 1970s Apollo LLR arrays contributed a negligible fraction of the ranging error budget. Since the ranging capabilities of ground stations improved by more than two orders of magnitude, now, because of the lunar librations, Apollo CCR arrays dominate the error budget. With the project MoonLIGHT (Moon Laser Instrumentation for General relativity High-accuracy Tests, in 2006 INFN-LNF joined UMD in the development and test of a new-generation LLR payload made by a single, large CCR (100mm diameter unaffected by the effect of librations. With MoonLIGHT CCRs the accuracy of the measurement of the lunar geodetic precession can be improved up to a factor 100 compared to Apollo arrays. From a technological point of view, INFN-LNF built and is operating a new experimental apparatus (Satellite/lunar laser ranging Characterization Facility, SCF and created a new industry-standard test procedure (SCF-Test to characterize and model the detailed thermal behavior and the optical performance of CCRs in accurately laboratory-simulated space conditions, for industrial and scientific applications. Our key experimental innovation is the concurrent measurement and modeling of the optical Far Field Diffraction Pattern (FFDP and the

  7. The potential role of real-time geodetic observations in tsunami early warning

    Science.gov (United States)

    Tinti, Stefano; Armigliato, Alberto

    2016-04-01

    experimental or testing stage and haven't been implemented yet in any standard TWS operations. Nonetheless, this is seen to be the future and the natural TWS evolving enhancement. In this context, improvement of the real-time estimates of tsunamigenic earthquake focal mechanism is of fundamental importance to trigger the appropriate computational chain. Quick discrimination between strike-slip and thrust-fault earthquakes, and equally relevant, quick assessment of co-seismic on-fault slip distribution, are exemplary cases to which a real-time geodetic monitoring system can contribute significantly. Robust inversion of geodetic data can help to reconstruct the sea floor deformation pattern especially if two conditions are met: the source is not too far from network stations and is well covered azimuthally. These two conditions are sometimes hard to satisfy fully, but in certain regions, like the Mediterranean and the Caribbean sea, this is quite possible due to the limited size of the ocean basins. Close cooperation between the Global Geodetic Observing System (GGOS) community, seismologists, tsunami scientists and TWS operators is highly recommended to obtain significant progresses in the quick determination of the earthquake source, which can trigger a timely estimation of the ensuing tsunami and a more reliable and detailed assessment of the tsunami size at the coast.

  8. Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: results from the recidivism of alcohol-impaired driving (ROAD) study.

    Science.gov (United States)

    Maenhout, Thomas M; Poll, Anneleen; Vermassen, Tijl; De Buyzere, Marc L; Delanghe, Joris R

    2014-01-01

    In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. A logistic regression analysis revealed that ln(%CDT) (P drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index ≥ 25%; third tertile) could be distinguished from drivers with an intermediate risk (16% ≤ ROAD index drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism. © 2013 Society for the Study of Addiction.

  9. Installation of a seafloor geodetic network offshore northern Chile (GeoSEA)

    Science.gov (United States)

    Kopp, Heidrun; Lange, Dietrich; Hannemann, Katrin; Petersen, Florian; Contreras-Reyes, Eduardo

    2016-04-01

    The seafloor stores crucial information on sub-seafloor processes, including stress, elastic strain, and earthquake and tsunami generation. This information may be extracted through the nascent scientific field of seafloor geodesy. The target of the recently installed GeoSEA array (Geodetic Earthquake Observatory on the SEAfloor) is to measure crustal deformation in mm-scale on the marine forearc and outer rise of the South American subduction system around 21°S. This segment of the Nazca-South American plate boundary has last ruptured in an earthquake in 1877 and was identified as a seismic gap prior to the 2014 Iquique/Pisagua earthquake (Mw=8.1). The southern portion of the segment remains unbroken by a recent earthquake. Seafloor geodetic measurements provide a way to monitor crustal deformation at high resolution comparable to the satellite-based GPS technique upon which terrestrial geodesy is largely based. The GeoSEA Network consists of autonomous seafloor transponders installed on 4 m high tripods, which were lowered to the seabed on the deep-sea cable of RV SONNE in December 2015. The transponders within an array intercommunicate via acoustic signals for a period of up to 3.5 years and measure acoustic distance, tilt and pressure. An additional component of the network is GeoSURF, a self-steering autonomous surface vehicle (Wave Glider), which monitors system health and is capable to upload the seafloor data to the sea surface and to transfer it via satellite. We have chosen three areas on the middle and lower slope and the outer rise for the set-up of three sub-arrays. The array in Area 1 on the middle continental slope consists of 8 transponders located in pairs on four topographic ridges, which are surface expressions of faults at depth. Area 2 is located on the outer rise seaward of the trench where 5 stations monitor extension across plate-bending related normal faults. The third area is located at water depth >5000 m on the lower continental slope

  10. Geodetic Measurements and Mechanical Models of Cyclic Deformation at Okmok Volcano, Alaska

    Science.gov (United States)

    Feigl, K.; Masterlark, T.; Lu, Z.; Ohlendorf, S. J.; Thurber, C. H.; Sigmundsson, F.

    2009-12-01

    The 1997 and 2008 eruptions of Okmok volcano, Alaska, provide a rare opportunity for conducting a rheological experiment to unravel the complex processes associated with magma migration, storage, and eruption in an active volcano. In this experiment, the magma flux during the eruption provides the “impulse” and the subsequent, transient deformation, the “response”. By simulating the impulse, measuring the response, and interpreting the constitutive relations between the two, one can infer the rheology. Okmok is an excellent natural laboratory for such an experiment because a complete cycle of deformation has been monitored using geodetic and seismic means, including: (a) geodetic time series from Interferometric Synthetic Aperture Radar (InSAR) and the Global Positioning System (GPS), (b) earthquake locations; and (c) seismic tomography. We are developing quantitative models using the Finite Element Method (FEM) to simulate the timing and location of the observed seismicity and deformation by accounting for: (a) the geometry and loading of the magma chamber and lava flow, (b) the spatial distribution of material properties; and (c) the constitutive (rheological) relations between stress and strain. Here, we test the hypothesis that the deformation following the 1997 eruption did not reach a steady state before the eruption in 2008. To do so, we iteratively confront the FEM models with the InSAR measurements using the General Inversion of Phase Technique (GIPhT). This approach models the InSAR phase data directly, without unwrapping, as developed, validated, and applied by Feigl and Thurber [Geophys. J. Int., 2009]. By minimizing a cost function that quantifies the misfit between observed and modeled values in terms of “wrapped” phase (with values ranging from -1/2 to +1/2 cycles), GIPhT can estimate parameters in a geophysical model. By avoiding the pitfalls of phase-unwrapping approaches, GIPhT allows the analysis, interpretation and modeling of more

  11. Seismicity and seismic hazard in Sabah, East Malaysia from earthquake and geodetic data

    Science.gov (United States)

    Gilligan, A.; Rawlinson, N.; Tongkul, F.; Stephenson, R.

    2017-12-01

    While the levels of seismicity are low in most of Malaysia, the state of Sabah in northern Borneo has moderate levels of seismicity. Notable earthquakes in the region include the 1976 M6.2 Lahad Datu earthquake and the 2015 M6 Ranau earthquake. The recent Ranau earthquake resulted in the deaths of 18 people on Mt Kinabalu, an estimated 100 million RM ( US$23 million) damage to buildings, roads, and infrastructure from shaking, and flooding, reduced water quality, and damage to farms from landslides. Over the last 40 years the population of Sabah has increased to over four times what it was in 1976, yet seismic hazard in Sabah remains poorly understood. Using seismic and geodetic data we hope to better quantify the hazards posed by earthquakes in Sabah, and thus help to minimize risk. In order to do this we need to know about the locations of earthquakes, types of earthquakes that occur, and faults that are generating them. We use data from 15 MetMalaysia seismic stations currently operating in Sabah to develop a region-specific velocity model from receiver functions and a pre-existing surface wave model. We use this new velocity model to (re)locate earthquakes that occurred in Sabah from 2005-2016, including a large number of aftershocks from the 2015 Ranau earthquake. We use a probabilistic nonlinear earthquake location program to locate the earthquakes and then refine their relative locations using a double difference method. The recorded waveforms are further used to obtain moment tensor solutions for these earthquakes. Earthquake locations and moment tensor solutions are then compared with the locations of faults throughout Sabah. Faults are identified from high-resolution IFSAR images and subsequent fieldwork, with a particular focus on the Lahad Datau and Ranau areas. Used together, these seismic and geodetic data can help us to develop a new seismic hazard model for Sabah, as well as aiding in the delivery of outreach activities regarding seismic hazard

  12. THE ROLE OF ASTRO-GEODETIC IN PRECISE GUIDANCE OF LONG TUNNELS

    Directory of Open Access Journals (Sweden)

    M. Mirghasempour

    2015-12-01

    Full Text Available One of prime aspects of surveying projects is guidance of paths of a long tunnel from different directions and finally ending all paths in a specific place. This kind of underground surveying, because of particular condition, has some different points in relation to the ground surveying, including Improper geometry in underground transverse, low precise measurement in direction and length due to condition such as refraction, distinct gravity between underground point and corresponding point on the ground (both value and direction of gravity and etc. To solve this problems, astro-geodetic that is part of geodesy science, can help surveying engineers. In this article, the role of astronomy is defined in two subjects: 1- Azimuth determination of directions from entrance and exit nets of tunnel and also calibration of gyro-theodolite to use them in Underground transvers: By astronomical methods, azimuth of directions can be determine with an accuracy of 0.5 arcsecond, whereas, nowadays, no gyroscope can measure the azimuth in this accuracy; For instance, accuracy of the most precise gyroscope (Gyromat 5000 is 1.2 cm over a distance of one kilometre (2.4 arcsecond. Furthermore, the calibration methods that will be mention in this article, have significance effects on underground transverse. 2- Height relation between entrance point and exit point is problematic and time consuming; For example, in a 3 km long tunnel ( in Arak- Khoram Abad freeway, to relate entrance point to exit point, it is necessary to perform levelling about 90 km. Other example of this boring and time consuming levelling is in Kerman tunnel. This tunnel is 36 km length, but to transfer the entrance point height to exit point, 150 km levelling is needed. According to this paper, The solution for this difficulty is application of astro-geodetic and determination of vertical deflection by digital zenith camera system TZK2-D. These two elements make possible to define geoid profile

  13. Underestimation of Severity of Previous Whiplash Injuries

    Science.gov (United States)

    Naqui, SZH; Lovell, SJ; Lovell, ME

    2008-01-01

    INTRODUCTION We noted a report that more significant symptoms may be expressed after second whiplash injuries by a suggested cumulative effect, including degeneration. We wondered if patients were underestimating the severity of their earlier injury. PATIENTS AND METHODS We studied recent medicolegal reports, to assess subjects with a second whiplash injury. They had been asked whether their earlier injury was worse, the same or lesser in severity. RESULTS From the study cohort, 101 patients (87%) felt that they had fully recovered from their first injury and 15 (13%) had not. Seventy-six subjects considered their first injury of lesser severity, 24 worse and 16 the same. Of the 24 that felt the violence of their first accident was worse, only 8 had worse symptoms, and 16 felt their symptoms were mainly the same or less than their symptoms from their second injury. Statistical analysis of the data revealed that the proportion of those claiming a difference who said the previous injury was lesser was 76% (95% CI 66–84%). The observed proportion with a lesser injury was considerably higher than the 50% anticipated. CONCLUSIONS We feel that subjects may underestimate the severity of an earlier injury and associated symptoms. Reasons for this may include secondary gain rather than any proposed cumulative effect. PMID:18201501

  14. Previous exposure in a high-risk area for travellers' diarrhoea within the past year is associated with a significant protective effect for travellers' diarrhoea: a prospective observational cohort study in travellers to South Asia.

    Science.gov (United States)

    Kuenzli, Esther; Juergensen, David; Kling, Kerstin; Jaeger, Veronika K; DeCrom, Susan; Steffen, Robert; Widmer, Andreas F; Battegay, Manuel; Hatz, Christoph; Neumayr, Andreas

    2017-09-01

    Travellers' diarrhoea is the most common health problem in travellers. Depending on the region visited, up to 40% of travellers develop diarrhoea during a 2-week trip. The aim of this study was to assess risk factors for TD among travellers to the Indian subcontinent. An observational prospective multicentre cohort study investigated travellers to the Indian subcontinent. Participants completed questionnaires assessing the incidence of travellers' diarrhoea and identifying potential risk factors. Covariates were assessed univariately, followed by a multivariate regression. Two-hundred and twenty-six travellers were enrolled into the study, 178 filled in both pre- and post-travel questionnaires. Overall, the attack rate of travellers' diarrhoea was 38.2%. Travel destination is a key risk factor for the occurrence of TD. Travelling to India or Nepal vs Bhutan is associated with an increased risk for TD (OR 6.68 and 6.62, respectively). A length of stay of more than 3 weeks compared to less than 2 weeks is also associated with a significantly increased risk (OR 5.45). Having stayed in a high-risk area for travellers' diarrhoea within the past year before the current trip is associated with a significantly decreased risk (OR 0.19). No association was found between consumption of high risk food (i.e. tap water, ice cream, raw meat and hamburgers) and travellers' diarrhoea. Travellers' diarrhoea is a frequent problem in travellers to the Indian subcontinent. Previous exposure in a high-risk area for travellers' diarrhoea within the past year appears to have a significant protective effect. Furthermore, an association between the occurrence of travellers' diarrhoea and travel destination and length of stay, respectively, was observed. Consumption of risk food did not confer a TD risk in our study. © International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  15. Data Records derived from GEOSAT Geodetic Mission (GM) and Exact Repeat Mission (ERM) data from 30 March 1985 to 31 December 1989

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection contains Sensor Data Records (SDRs), Geodetic Data Records (GDRs), Waveform Data Records (WDRs), and Crossover Difference data Records (XDRs) from...

  16. Myocardial adaption to HI(R)T in previously untrained men with a randomized, longitudinal cardiac MR imaging study (Physical adaptions in Untrained on Strength and Heart trial, PUSH-trial).

    Science.gov (United States)

    Scharf, Michael; Oezdemir, Derya; Schmid, Axel; Kemmler, Wolfgang; von Stengel, Simon; May, Matthias S; Uder, Michael; Lell, Michael M

    2017-01-01

    Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance) training (HI(R)T) induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI) study. 80 untrained middle-aged men were randomly assigned to a HI(R)T-group (n = 40; 43.5±5.9 years) or an inactive control group (n = 40; 42.0±6.3 years). HI(R)T comprised 22 weeks of training focusing on a single-set to failure protocol in 2-3 sessions/week, each with 10-13 exercises addressing main muscle groups. Repetitions were decreased from 8-10 to 3-5 during study period. Before and after HI(R)T all subjects underwent physiologic examination and cardiac MRI (cine imaging, tagging). Indexed left (LV) and right ventricular (RV) volume (LV: 76.8±15.6 to 78.7±14.8 ml/m2; RV: 77.0±15.5 to 78.7±15.1 ml/m2) and mass (LV: 55.5±9.7 to 57.0±8.8 g/m2; RV: 14.6±3.0 to 15.0±2.9 g/m2) significantly increased with HI(R)T (all pHI(R)T-group did not alter with training (0.73g/mL and 0.19g/mL, respectively [p = 0.96 and p = 0.87]), indicating balanced cardiac adaption. Indexed LV (48.4±11.1 to 50.8±11.0 ml/m2) and RV (48.5±11.0 to 50.6±10.7 ml/m2) stroke volume significantly increased with HI(R)T (pHI(R)T (36.2±7.9 to 37.0±8.4 ml/m2, p = 0.411), the ratio to end-diastolic LV volume at baseline and post-training was unchanged (0.47 vs. 0.47, p = 0.79). 22 weeks of HI(R)T lead to measurable, physiological changes in cardiac atrial and ventricular morphologic characteristics and function in previously untrained men. The PUSH-trial is registered at the US National Institutes of Health (ClinicalTrials.gov), NCT01766791.

  17. Robust adjustment of a geodetic network measured by satellite technology in the Dargovských Hrdinov suburb

    Directory of Open Access Journals (Sweden)

    Slavomír Labant

    2011-12-01

    Full Text Available This article addresses the adjustment of a 3D geodetic network in the Dargovských Hrdinov suburbs using Global Navigation SatelliteSystems (GNSS for the purposes of deformation analysis. The advantage of using the GNSS compared to other terrestrial technology is thatit is not influenced by unpredictability in the ground level atmosphere and individual visibilities between points in the observed network arenot necessary. This article also includes the planning of GNSS observations using Planning Open Source software from Trimble as well assubsequent observations at individual network points. The geodetic network is processing on the basis of the Gauss-Markov model usingthe least square method and robust adjustment. From robust methods, Huber’s Robust M-estimation and Hampel’s Robust M-estimationwere used. Individual adjustments were tested and subsequently the results of analysis were graphically visualised using absolute confidenceellipsoids.

  18. Geodetic, Geologic and Seismic Interdisciplinary Research of Tectonically Caused Movements in the Wider Area of the City of Zagreb

    Science.gov (United States)

    Dapo, A.; Pribicevic, B.; Herak, M.; Prelogovic, E.

    2012-04-01

    Since the last great earthquake in 1880 which shook the Zagreb area with IX° MCS, tectonic movements and models of numerous Zagreb faults have been the focal point of Croatian geologists, seismologists and in the last 15 years also geodetic scientists, who all have been working in the scope of their scientific branches on bringing the light to the tectonic mechanisms in the wider Zagreb area. Since it is tectonically very active area and being the Capitol city of the Croatia with very high population density it is of utmost importance to understand those mechanisms and to according to them find the best possible measures for protecting people and valuables. Best results are certainly going to be achieved through the interdisciplinary approach. That is why this paper presents first interdisciplinary results from geodetic, geologic and seismic researches and their contribution to the collective knowledge about tectonic movements in the wider area of the City of Zagreb.

  19. The combined geodetic network adjusted on the reference ellipsoid – a comparison of three functional models for GNSS observations

    Directory of Open Access Journals (Sweden)

    Kadaj Roman

    2016-12-01

    Full Text Available The adjustment problem of the so-called combined (hybrid, integrated network created with GNSS vectors and terrestrial observations has been the subject of many theoretical and applied works. The network adjustment in various mathematical spaces was considered: in the Cartesian geocentric system on a reference ellipsoid and on a mapping plane. For practical reasons, it often takes a geodetic coordinate system associated with the reference ellipsoid. In this case, the Cartesian GNSS vectors are converted, for example, into geodesic parameters (azimuth and length on the ellipsoid, but the simple form of converted pseudo-observations are the direct differences of the geodetic coordinates. Unfortunately, such an approach may be essentially distorted by a systematic error resulting from the position error of the GNSS vector, before its projection on the ellipsoid surface. In this paper, an analysis of the impact of this error on the determined measures of geometric ellipsoid elements, including the differences of geodetic coordinates or geodesic parameters is presented. Assuming that the adjustment of a combined network on the ellipsoid shows that the optimal functional approach in relation to the satellite observation, is to create the observational equations directly for the original GNSS Cartesian vector components, writing them directly as a function of the geodetic coordinates (in numerical applications, we use the linearized forms of observational equations with explicitly specified coefficients. While retaining the original character of the Cartesian vector, one avoids any systematic errors that may occur in the conversion of the original GNSS vectors to ellipsoid elements, for example the vector of the geodesic parameters. The problem is theoretically developed and numerically tested. An example of the adjustment of a subnet loaded from the database of reference stations of the ASG-EUPOS system was considered for the preferred functional

  20. ALGORITHMS VARIANTS OF ELABORATION OF THE PRECISE GNSS NETWORK ESTABLISHED FOR GEODETIC SERVICE OF BUILDING OF THE MINING FACILITY

    Directory of Open Access Journals (Sweden)

    Ryszard MIELIMĄKA

    2014-10-01

    Full Text Available The article presents the problem of the usage of post‐processing services of the ASG‐EUPOS system on the example of GNSS network established for geodetic service of building of the inclined drift, to make coal deposit accessible, and also building associated objects. For the purpose of geodetic service of construction realization network was established outside the planned objects. The network consists of six new ground points and four control points belonging to ASG‐EUPOS network. Simultaneous, static measurements of the network were performed in three‐hour observation session, using multi‐frequency and multi‐system satellite receivers – Trimble R8. The paper presents three variants of post‐processing of the observation results. Calculations were performed using POZGEO‐D service and geodetic software package GEONET. The results of the calculation process revealed, that homogeneous vector networks should be adjusted on the ellipsoid or in the geocentric system. Model of adjustment of the vector network on the plane adopted in the GEONET software package should not be applied for elaboration of this type of network (long reference vectors more than 50km.

  1. The astro-geodetic use of CCD for gravity field refinement

    Science.gov (United States)

    Gerstbach, G.

    1996-07-01

    The paper starts with a review of geoid projects, where vertical deflections are more effective than gravimetry. In alpine regions the economy of astrogeoids is at least 10 times higher, but many countries do not make use of this fact - presumably because the measurements are not fully automated up to now. Based upon the experiences of astrometry of high satellites and own tests the author analyses the use of CCD for astro-geodetic measurements. Automation and speeding up will be possible in a few years, the latter depending on the observation scheme. Sensor characteristics, cooling and reading out of the devices should be harmonized. Using line sensors in small prism astrolabes, the CCD accuracy will reach the visual one (±0.2″) within 5-10 years. Astrogeoids can be combined ideally with geological data, because vertical variation of rock densities does not cause systematic effects (contrary to gravimetry). So a geoid of ±5 cm accuracy (achieved in Austria and other alpine countries by 5-10 points per 1000 km 2) can be improved to ±2 cm without additional observations and border effects.

  2. Geodetic Finite-Fault-based Earthquake Early Warning Performance for Great Earthquakes Worldwide

    Science.gov (United States)

    Ruhl, C. J.; Melgar, D.; Grapenthin, R.; Allen, R. M.

    2017-12-01

    GNSS-based earthquake early warning (EEW) algorithms estimate fault-finiteness and unsaturated moment magnitude for the largest, most damaging earthquakes. Because large events are infrequent, algorithms are not regularly exercised and insufficiently tested on few available datasets. The Geodetic Alarm System (G-larmS) is a GNSS-based finite-fault algorithm developed as part of the ShakeAlert EEW system in the western US. Performance evaluations using synthetic earthquakes offshore Cascadia showed that G-larmS satisfactorily recovers magnitude and fault length, providing useful alerts 30-40 s after origin time and timely warnings of ground motion for onshore urban areas. An end-to-end test of the ShakeAlert system demonstrated the need for GNSS data to accurately estimate ground motions in real-time. We replay real data from several subduction-zone earthquakes worldwide to demonstrate the value of GNSS-based EEW for the largest, most damaging events. We compare predicted ground acceleration (PGA) from first-alert-solutions with those recorded in major urban areas. In addition, where applicable, we compare observed tsunami heights to those predicted from the G-larmS solutions. We show that finite-fault inversion based on GNSS-data is essential to achieving the goals of EEW.

  3. Space geodetic observations of repeating slow slip events beneath the Bonin Islands

    Science.gov (United States)

    Arisa, Deasy; Heki, Kosuke

    2017-09-01

    The Pacific Plate subducts beneath the Philippine Sea Plate along the Izu-Bonin Trench. We investigated crustal movements at the Bonin Islands, using Global Navigation Satellite System and geodetic Very Long Baseline Interferometry data to reveal how the two plates converge in this subduction zone. These islands are located ∼100 km from the trench, just at the middle between the volcanic arc and the trench, making these islands suitable for detecting signatures of episodic deformation such as slow slip events (SSEs). During 2007-2016, we found five SSEs repeating quasi-periodically with similar displacement patterns. In estimating their fault parameters, we assumed that the fault lies on the prescribed plate boundary, and optimized the size, shape and position of the fault and dislocation vectors. Average fault slip was ∼5 cm, and the average moment magnitude was ∼6.9. We also found one SSE occurred in 2008 updip of the repeating SSE in response to an M6 class interplate earthquake. In spite of the frequent occurrence of SSEs, there is no evidence for long-term strain accumulation in the Bonin Islands that may lead to future megathrust earthquakes. Plate convergence in Mariana-type subduction zones may occur, to a large extent, episodically as repeating SSEs.

  4. Applications of Voronoi and Delaunay Diagrams in the solution of the geodetic boundary value problem

    Directory of Open Access Journals (Sweden)

    C. A. B. Quintero

    Full Text Available Voronoi and Delaunay structures are presented as discretization tools to be used in numerical surface integration aiming the computation of geodetic problems solutions, when under the integral there is a non-analytical function (e. g., gravity anomaly and height. In the Voronoi approach, the target area is partitioned into polygons which contain the observed point and no interpolation is necessary, only the original data is used. In the Delaunay approach, the observed points are vertices of triangular cells and the value for a cell is interpolated for its barycenter. If the amount and distribution of the observed points are adequate, gridding operation is not required and the numerical surface integration is carried out by point-wise. Even when the amount and distribution of the observed points are not enough, the structures of Voronoi and Delaunay can combine grid with observed points in order to preserve the integrity of the original information. Both schemes are applied to the computation of the Stokes' integral, the terrain correction, the indirect effect and the gradient of the gravity anomaly, in the State of Rio de Janeiro, Brazil area.

  5. Congruence analysis of geodetic networks - hypothesis tests versus model selection by information criteria

    Science.gov (United States)

    Lehmann, Rüdiger; Lösler, Michael

    2017-12-01

    Geodetic deformation analysis can be interpreted as a model selection problem. The null model indicates that no deformation has occurred. It is opposed to a number of alternative models, which stipulate different deformation patterns. A common way to select the right model is the usage of a statistical hypothesis test. However, since we have to test a series of deformation patterns, this must be a multiple test. As an alternative solution for the test problem, we propose the p-value approach. Another approach arises from information theory. Here, the Akaike information criterion (AIC) or some alternative is used to select an appropriate model for a given set of observations. Both approaches are discussed and applied to two test scenarios: A synthetic levelling network and the Delft test data set. It is demonstrated that they work but behave differently, sometimes even producing different results. Hypothesis tests are well-established in geodesy, but may suffer from an unfavourable choice of the decision error rates. The multiple test also suffers from statistical dependencies between the test statistics, which are neglected. Both problems are overcome by applying information criterions like AIC.

  6. Development of AN Open-Source Automatic Deformation Monitoring System for Geodetical and Geotechnical Measurements

    Science.gov (United States)

    Engel, P.; Schweimler, B.

    2016-04-01

    The deformation monitoring of structures and buildings is an important task field of modern engineering surveying, ensuring the standing and reliability of supervised objects over a long period. Several commercial hardware and software solutions for the realization of such monitoring measurements are available on the market. In addition to them, a research team at the Neubrandenburg University of Applied Sciences (NUAS) is actively developing a software package for monitoring purposes in geodesy and geotechnics, which is distributed under an open source licence and free of charge. The task of managing an open source project is well-known in computer science, but it is fairly new in a geodetic context. This paper contributes to that issue by detailing applications, frameworks, and interfaces for the design and implementation of open hardware and software solutions for sensor control, sensor networks, and data management in automatic deformation monitoring. It will be discussed how the development effort of networked applications can be reduced by using free programming tools, cloud computing technologies, and rapid prototyping methods.

  7. Geodetically resolved slip distribution of the 27 August 2012 Mw=7.3 El Salvador earthquake

    Science.gov (United States)

    Geirsson, H.; La Femina, P. C.; DeMets, C.; Hernandez, D. A.; Mattioli, G. S.; Rogers, R.; Rodriguez, M.

    2013-12-01

    On 27 August 2012 a Mw=7.3 earthquake occurred offshore of Central America causing a small tsunami in El Salvador and Nicaragua but little damage otherwise. This is the largest magnitude earthquake in this area since 2001. We use co-seismic displacements estimated from episodic and continuous GPS station time series to model the magnitude and spatial variability of slip for this event. The estimated surface displacements are small (earthquake. We use TDEFNODE to model the displacements using two different modeling approaches. In the first model, we solve for homogeneous slip on free rectangular fault(s), and in the second model we solve for distributed slip on the main thrust, realized using different slab models. The results indicate that we can match the seismic moment release, with models indicating rupture of a large area, with a low magnitude of slip. The slip is at shallow-to-intermediate depths on the main thrust off the coast of El Salvador. Additionally, we observe a deeper region of slip to the east, that reaches towards the Gulf of Fonseca between El Salvador and Nicaragua. The observed tsunami additionally indicates near-trench rupture off the coast of El Salvador. The duration of the rupturing is estimated from seismic data to be 70 s, which indicates a slow rupture process. Since the geodetic moment we obtain agrees with the seismic moment, this indicates that the earthquake was not associated with aseismic slip.

  8. THE LIS STUDY (LYUBERTSY STUDY ON MORTALITY RATE IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION. EVALUATION OF DRUG THERAPY. PART 2. INFLUENCE OF PREVIOUS DRUG TREATMENT ON LONG-TERM LIFE PROGNOSIS

    Directory of Open Access Journals (Sweden)

    S. Yu. Martsevich

    2015-12-01

    Full Text Available Aim. To evaluate drug therapy received by patients who had survived acute myocardial infarction (AMI in the framework of the AMI register (the “LIS” study and estimate this therapy influence on long-term outcomes of the disease. Material and methods. The total of 961 patients of 1133 enrolled in the “LIS” study , were discharged from hospital. 191 patients had died during follow-up. 632 patients (who had survived and consented to visit out-patient clinic underwent repeated examination (median of follow-up 1.6 [1.0; 2.4] years. Data about treatment before and during AMI were received from patient’s charts; data about treatment after AMI were obtained from out-patient medical records. Results. Before reference AMI only a small number of the patients received the main drug groups (antiplatelet agents, β-blockers, ACE inhibitors, statins, at that ACE inhibitors were prescribed more often than the others. Use of β-blockers and ACE inhibitors before reference AMI significantly improved long-term life prognosis [relative risk (RR 0.70 and 0.66, respectively]. Rate of the main drug groups prescribed in hospital was rather high with the exception of thrombolytics (less than 10%. Thrombolytics, β-blockers and antiplatelet agents prescribed in hospital significantly improved long-term life prognosis of patients (RR 0.42, 0.65 and 0.58 respectively. At the second visit (according to data of out-patient medical records rate of antiplatelet agents, ACE inhibitors, β-blockers and statins prescription exceeded 60%. Conclusion. Very low prevalence of adequate drug therapy preceding AMI determines high mortality rate among survived acute stage of myocardial infarction patients in long-term period.

  9. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.

    1959-01-01

    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  10. 77 FR 70176 - Previous Participation Certification

    Science.gov (United States)

    2012-11-23

    ... participants' previous participation in government programs and ensure that the past record is acceptable prior... information is designed to be 100 percent automated and digital submission of all data and certifications is... government programs and ensure that the past record is acceptable prior to granting approval to participate...

  11. Evaluation of a New Prototype Geodetic Astrolabe for Measuring Deflections of the Vertical

    Science.gov (United States)

    Slater, J. A.; Thompson, N.; Angell, L. E.; Belenkii, M. S.; Bruns, D. G.; Johnson, D. O.

    2009-12-01

    During the last three years, the National Geospatial-Intelligence Agency (NGA), with assistance from the U.S. Naval Observatory (USNO), sponsored the development of a new electronic geodetic astrolabe for measuring deflections of the vertical (DoV). NGA’s current operational astrolabes, built in 1995, have a number of undesirable features including the need for a pool of liquid mercury as a reflecting surface. The new state-of-the-art prototype instrument, completed by Trex Enterprises in early 2009, was designed to meet a 0.2 arcsec accuracy requirement. It reduces the weight, eliminates the mercury, and dramatically reduces observation times. The new astrolabe consists of a 101 mm aperture telescope with a 1.5° field of view and an inclinometer mounted inside a 92-cm high, 30-cm diameter tube, an external GPS receiver for timing, and a laptop computer that controls and monitors the instrument and performs the computations. Star images are recorded by an astronomical-grade camera with a 2,048 x 2,048 pixel CCD sensor that is externally triggered by time pulses from the GPS receiver. The prototype was designed for nighttime observation of visible stars equal to or brighter than magnitude 10.0. The inclinometer is a system of two orthogonal pendula that define the local gravitational vertical, each consisting of a brass plumb bob suspended from an aluminized polymer ribbon set between two electrodes. An internal reference collimator is rigidly tied to the inclinometer and projects an array of reference points of light onto the CCD sensor. After the astrolabe is coarsely leveled to within 20 arcsec, voice coil actuators automatically adjust and maintain the inclinometer vertical to within 0.02 arcsec. Independent images are collected at 6 second intervals using a 200 msec exposure time. The CCD coordinates are determined for each star and a collimator reference point on each image. Stars are identified by referencing a customized star catalog produced by USNO. A

  12. Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

    Science.gov (United States)

    Leonard, John P; Kolibaba, Kathryn S; Reeves, James A; Tulpule, Anil; Flinn, Ian W; Kolevska, Tatjana; Robles, Robert; Flowers, Christopher R; Collins, Robert; DiBella, Nicholas J; Papish, Steven W; Venugopal, Parameswaran; Horodner, Andrew; Tabatabai, Amir; Hajdenberg, Julio; Park, Jaehong; Neuwirth, Rachel; Mulligan, George; Suryanarayan, Kaveri; Esseltine, Dixie-Lee; de Vos, Sven

    2017-11-01

    Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL). Patients and Methods After real-time determination of non-GCB DLBCL using the Hans immunohistochemistry algorithm, 206 patients were randomly assigned (1:1; stratified by International Prognostic Index [IPI] score) to six 21-day cycles of standard R-CHOP alone or R-CHOP plus bortezomib 1.3 mg/m 2 intravenously on days 1 and 4 (VR-CHOP). The primary end point, progression-free survival (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or more doses of study drug (91 R-CHOP, 92 VR-CHOP). Results After a median follow-up of 34 months, with 25% (R-CHOP) and 18% (VR-CHOP) of patients having had PFS events, the hazard ratio (HR) for PFS was 0.73 (90% CI, 0.43 to 1.24) with VR-CHOP ( P = .611). Two-year PFS rates were 77.6% with R-CHOP and 82.0% with VR-CHOP; they were 65.1% versus 72.4% in patients with high-intermediate/high IPI (HR, 0.67; 90% CI, 0.34 to 1.29), and 90.0% versus 88.9% (HR, 0.85; 90% CI, 0.35 to 2.10) in patients with low/low-intermediate IPI. Overall response rate with R-CHOP and VR-CHOP was 98% and 96%, respectively. The overall survival HR was 0.75 (90% CI, 0.38 to 1.45); 2-year survival rates were 88.4% and 93.0%, respectively. In the safety population (100 R-CHOP and 101 VR-CHOP patients), grade ≥ 3 adverse events included neutropenia (53% v 49%), thrombocytopenia (13% v 29%), anemia (7% v 15%), leukopenia (26% v 25%), and neuropathy (1% v 5%). Conclusion Outcomes for newly diagnosed, prospectively enrolled patients with non-GCB DLBCL were more favorable than expected with R-CHOP and were not significantly improved by adding bortezomib.

  13. Self-force correction to geodetic spin precession in Kerr spacetime

    Science.gov (United States)

    Akcay, Sarp

    2017-08-01

    We present an expression for the gravitational self-force correction to the geodetic spin precession of a spinning compact object with small, but non-negligible mass in a bound, equatorial orbit around a Kerr black hole. We consider only conservative backreaction effects due to the mass of the compact object (m1), thus neglecting the effects of its spin s1 on its motion; i.e., we impose s1≪G m12/c and m1≪m2, where m2 is the mass parameter of the background Kerr spacetime. We encapsulate the correction to the spin precession in ψ , the ratio of the accumulated spin-precession angle to the total azimuthal angle over one radial orbit in the equatorial plane. Our formulation considers the gauge-invariant O (m1) part of the correction to ψ , denoted by Δ ψ , and is a generalization of the results of Akcay et al. [Classical Quantum Gravity 34, 084001 (2017), 10.1088/1361-6382/aa61d6] to Kerr spacetime. Additionally, we compute the zero-eccentricity limit of Δ ψ and show that this quantity differs from the circular orbit Δ ψcirc by a gauge-invariant quantity containing the gravitational self-force correction to general relativistic periapsis advance in Kerr spacetime. Our result for Δ ψ is expressed in a manner that readily accommodates numerical/analytical self-force computations, e.g., in the radiation gauge, and paves the way for the computation of a new eccentric-orbit Kerr gauge invariant beyond the generalized redshift.

  14. Geodetic mass balance measurements on debris and clean-ice tropical glaciers in Ecuador

    Science.gov (United States)

    La Frenierre, J.; Decker, C. R.; Jordan, E.; Wigmore, O.; Hodge, B. E.; Niederriter, C.; Michels, A.

    2017-12-01

    Glaciers are recognized as highly sensitive indicators of climate change in high altitude, low latitude environments. In the tropical Andes, various analyses of glacier surface area change have helped illuminate the manifestation of climate change in this region, however, information about actual glacier mass balance behavior is much more limited given the relatively small glaciers, difficult access, poor weather, and/or limited local resources common here. Several new technologies, including aerial and terrestrial LIDAR and structure-from-motion photogrammetry using small unmanned aerial vehicles (UAVs), make mass balance measurements using geodetic approaches increasingly feasible in remote mountain locations, which can both further our understanding of changing climatic conditions, and improve our ability to evaluate the downstream hydrologic impacts of ice loss. At Volcán Chimborazo, Ecuador, these new technologies, combined with a unique, 5-meter resolution digital elevation model derived from 1997 aerial imagery, make possible an analysis of the magnitude and spatial patterns of mass balance behavior over the past two decades. Here, we evaluate ice loss between 1997 and 2017 at the tongues of two adjacent glaciers, one debris-covered and detached from its accumulation area (Reschreiter Glacier), and one debris-free and intact (Hans Meyer Glacier). Additionally, we incorporate data from 2012 and 2013 terrestrial LIDAR surveys to evaluate the behavior of the Reschreiter at a finer temporal resolution. We find that on the Hans Meyer, the mean surface deflation rate since 1997 at the present-day tongue has been nearly 3 m yr-1, while on the lower-elevation Reschreiter, the mean deflation rate has been approximately 1 m yr-1. However, the processes by which debris-covered ice becomes exposed results in highly heterogeneous patterns of ice loss, with some areas experiencing surface deflation rates approaching 15 m yr-1 when energy absorption is unimpeded.

  15. Geodetic integration of Sentinel-1A IW data using PSInSAR in Hungary

    Science.gov (United States)

    Farkas, Péter; Hevér, Renáta; Grenerczy, Gyula

    2015-04-01

    ESA's latest Synthetic Aperture Radar (SAR) mission Sentinel-1 is a huge step forward in SAR interferometry. With its default acquisition mode called the Interferometric Wide Swath Mode (IW) areas through all scales can be mapped with an excellent return time of 12 days (while only the Sentinel-1A is in orbit). Its operational data policy is also a novelty, it allows scientific users free and unlimited access to data. It implements a new type of ScanSAR mode called Terrain Observation with Progressive Scan (TOPS) SAR. It has the same resolution as ScanSAR but with better signal-to-noise ratio distribution. The bigger coverage is achieved by rotation of the antenna in the azimuth direction, therefore it requires very precise co-registration because even errors under a pixel accuracy can introduce azimuth phase variations caused by differences in Doppler-centroids. In our work we will summarize the benefits and the drawbacks of the IW mode. We would like to implement the processing chain of GAMMA Remote Sensing of such data for mapping surface motion with special attention to the co-registration step. Not only traditional InSAR but the advanced method of Persistent Scatterer InSAR (PSInSAR) will be performed and presented as well. PS coverage, along with coherence, is expected to be good due to the small perpendicular and temporal baselines. We would also like to integrate these measurements into national geodetic networks using common reference points. We have installed trihedral corner reflectors at some selected sites to aid precise collocation. Thus, we aim to demonstrate that Sentinel-1 can be effectively used for surface movement detection and monitoring and it can also provide valuable information for the improvement of our networks.

  16. Twenty-five years of geodetic measurements along the Tadjoura-Asal rift system, Djibouti, East Africa

    Science.gov (United States)

    Vigny, Christophe; de Chabalier, Jean-Bernard; Ruegg, Jean-Claude; Huchon, Philippe; Feigl, Kurt L.; Cattin, Rodolphe; Asfaw, Laike; Kanbari, Khaled

    2007-06-01

    Since most of Tadjoura-Asal rift system sits on dry land in the Afar depression near the triple junction between the Arabia, Somalia, and Nubia plates, it is an ideal natural laboratory for studying rifting processes. We analyze these processes in light of a time series of geodetic measurements from 1978 through 2003. The surveys used triangulation (1973), trilateration (1973, 1979, and 1981-1986), leveling (1973, 1979, 1984-1985, and 2000), and the Global Positioning System (GPS, in 1991, 1993, 1995, 1997, 1999, 2001, and 2003). A network of about 30 GPS sites covers the Republic of Djibouti. Additional points were also measured in Yemen and Ethiopia. Stations lying in the Danakil block have almost the same velocity as Arabian plate, indicating that opening near the southern tip of the Red Sea is almost totally accommodated in the Afar depression. Inside Djibouti, the Asal-Ghoubbet rift system accommodates 16 ± 1 mm/yr of opening perpendicular to the rift axis and exhibits a pronounced asymmetry with essentially null deformation on its southwestern side and significant deformation on its northeastern side. This rate, slightly higher than the large-scale Arabia-Somalia motion (13 ± 1 mm/yr), suggests transient variations associated with relaxation processes following the Asal-Ghoubbet seismovolcanic sequence of 1978. Inside the rift, the deformation pattern exhibits a clear two-dimensional pattern. Along the rift axis, the rate decreases to the northwest, suggesting propagation in the same direction. Perpendicular to the rift axis, the focus of the opening is clearly shifted to the northeast, relative to the topographic rift axis, in the "Petit Rift," a rift-in-rift structure, containing most of the active faults and the seismicity. Vertical motions, measured by differential leveling, show the same asymmetric pattern with a bulge of the northeastern shoulder. Although the inner floor of the rift is subsiding with respect to the shoulders, all sites within the

  17. Implant breast reconstruction after salvage mastectomy in previously irradiated patients.

    Science.gov (United States)

    Persichetti, Paolo; Cagli, Barbara; Simone, Pierfranco; Cogliandro, Annalisa; Fortunato, Lucio; Altomare, Vittorio; Trodella, Lucio

    2009-04-01

    The most common surgical approach in case of local tumor recurrence after quadrantectomy and radiotherapy is salvage mastectomy. Breast reconstruction is the subsequent phase of the treatment and the plastic surgeon has to operate on previously irradiated and manipulated tissues. The medical literature highlights that breast reconstruction with tissue expanders is not a pursuable option, considering previous radiotherapy a contraindication. The purpose of this retrospective study is to evaluate the influence of previous radiotherapy on 2-stage breast reconstruction (tissue expander/implant). Only patients with analogous timing of radiation therapy and the same demolitive and reconstructive procedures were recruited. The results of this study prove that, after salvage mastectomy in previously irradiated patients, implant reconstruction is still possible. Further comparative studies are, of course, advisable to draw any conclusion on the possibility to perform implant reconstruction in previously irradiated patients.

  18. Influence of the physico-chemical process as previous treatment to the electrocoagulation. Study with leachate of a landfill; Influencia del proceso fisicoquimico como tratamiento previo a la electrocoagulacion. Estudio con lixiviados de un relleno

    Energy Technology Data Exchange (ETDEWEB)

    Mercado Martinez, I. D.; Reyes Avila, D.

    2007-07-01

    This article has as purpose to show the influence of the method physico-chemical as previous process to the novel technique of electrocoagulation, presenting as a new alternative to depurate wastewaters. to obtain it, was done tests measuring the very parameters to leachates so much affluent as effluent from treatment plant of the Sanitary Landfill La Esmeralda, situated near to the Manizales city(Colombia), and so much before as later to apply this electrochemical technology, looking for this way to compare the obtained removals. (Author)

  19. Incorporating Geodetic Technologies in to Field and Campus Courses at the University of Michigan: Best Practices and Lessons Learned

    Science.gov (United States)

    Niemi, N. A.; Clark, M. K.

    2017-12-01

    For the past 6 years, the University of Michigan has implemented geodetic techniques into both summer field courses and on-campus courses. The primary means for incorporating these technologies has been a partnership with UNAVCO to introduce terrestrial laser scanning (TLS) at summer field courses, although employing Structure from Motion(SfM), ArcCollector for iPads and RTK GPS surveying have also been explored. The nature of these types of data lend themselves readily to geomorphology, environmental, and natural hazards-based projects, and we have developed field projects or labs around neotectonics (fault-scarp scanning and diffusion analysis), change detection (braided stream evolution, landslide and rock glacier motion, coastal change) and mass wasting processes (rock avalanche scanning and analysis). While we have primarily developed multi-day projects that use these tools in a field camp setting, we have also developed weekend field trip projects and traditional afternoon lab exercises associated with on-campus courses. The use of geodetic technology is generally well received by students. Reasons for this are the use of somewhat different skill sets from traditional geologic mapping problems, including research survey design, real-time data acquisition, and quantitative data analysis. Students also perceive that they are engaged in learning technology which they may use in their future employment. Challenges encountered, particularly in the field, include managing large student groups with a finite pool of equipment, rapid data processing pressures, variable student experience with analysis software and limited technical support for field-based computational resources. We will describe the positive attributes of incorporating geodetic technologies into undergraduate courses and elaborate on some best practices learned from our experiences.

  20. Slow Earthquake Hunters: A New Citizen Science Project to Identify and Catalog Slow Slip Events in Geodetic Data

    Science.gov (United States)

    Bartlow, N. M.

    2017-12-01

    Slow Earthquake Hunters is a new citizen science project to detect, catalog, and monitor slow slip events. Slow slip events, also called "slow earthquakes", occur when faults slip too slowly to generate significant seismic radiation. They typically take between a few days and over a year to occur, and are most often found on subduction zone plate interfaces. While not dangerous in and of themselves, recent evidence suggests that monitoring slow slip events is important for earthquake hazards, as slow slip events have been known to trigger damaging "regular" earthquakes. Slow slip events, because they do not radiate seismically, are detected with a variety of methods, most commonly continuous geodetic Global Positioning System (GPS) stations. There is now a wealth of GPS data in some regions that experience slow slip events, but a reliable automated method to detect them in GPS data remains elusive. This project aims to recruit human users to view GPS time series data, with some post-processing to highlight slow slip signals, and flag slow slip events for further analysis by the scientific team. Slow Earthquake Hunters will begin with data from the Cascadia subduction zone, where geodetically detectable slow slip events with a duration of at least a few days recur at regular intervals. The project will then expand to other areas with slow slip events or other transient geodetic signals, including other subduction zones, and areas with strike-slip faults. This project has not yet rolled out to the public, and is in a beta testing phase. This presentation will show results from an initial pilot group of student participants at the University of Missouri, and solicit feedback for the future of Slow Earthquake Hunters.

  1. Dynamic rupture modeling of the M7.2 2010 El Mayor-Cucapah earthquake: Comparison with a geodetic model

    Science.gov (United States)

    Kyriakopoulos, Christos; Oglesby, David D.; Funning, Gareth J.; Ryan, Kenneth

    2017-01-01

    The 2010 Mw 7.2 El Mayor-Cucapah earthquake is the largest event recorded in the broader Southern California-Baja California region in the last 18 years. Here we try to analyze primary features of this type of event by using dynamic rupture simulations based on a multifault interface and later compare our results with space geodetic models. Our results show that starting from homogeneous prestress conditions, slip heterogeneity can be achieved as a result of variable dip angle along strike and the modulation imposed by step over segments. We also considered effects from a topographic free surface and find that although this does not produce significant first-order effects for this earthquake, even a low topographic dome such as the Cucapah range can affect the rupture front pattern and fault slip rate. Finally, we inverted available interferometric synthetic aperture radar data, using the same geometry as the dynamic rupture model, and retrieved the space geodetic slip distribution that serves to constrain the dynamic rupture models. The one to one comparison of the final fault slip pattern generated with dynamic rupture models and the space geodetic inversion show good agreement. Our results lead us to the following conclusion: in a possible multifault rupture scenario, and if we have first-order geometry constraints, dynamic rupture models can be very efficient in predicting large-scale slip heterogeneities that are important for the correct assessment of seismic hazard and the magnitude of future events. Our work contributes to understanding the complex nature of multifault systems.

  2. GeoNetGIS: a Geodetic Network Geographical Information System to manage GPS networks in seismic and volcanic areas

    Science.gov (United States)

    Cristofoletti, P.; Esposito, A.; Anzidei, M.

    2003-04-01

    This paper presents the methodologies and issues involved in the use of GIS techniques to manage geodetic information derived from networks in seismic and volcanic areas. Organization and manipulation of different geodetical, geological and seismic database, give us a new challenge in interpretation of information that has several dimensions, including spatial and temporal variations, also the flexibility and brand range of tools available in GeoNetGIS, make it an attractive platform for earthquake risk assessment. During the last decade the use of geodetic networks based on the Global Positioning System, devoted to geophysical applications, especially for crustal deformation monitoring in seismic and volcanic areas, increased dramatically. The large amount of data provided by these networks, combined with different and independent observations, such as epicentre distribution of recent and historical earthquakes, geological and structural data, photo interpretation of aerial and satellite images, can aid for the detection and parameterization of seismogenic sources. In particular we applied our geodetic oriented GIS to a new GPS network recently set up and surveyed in the Central Apennine region: the CA-GeoNet. GeoNetGIS is designed to analyze in three and four dimensions GPS sources and to improve crustal deformation analysis and interpretation related with tectonic structures and seismicity. It manages many database (DBMS) consisting of different classes, such as Geodesy, Topography, Seismicity, Geology, Geography and Raster Images, administrated according to Thematic Layers. GeoNetGIS represents a powerful research tool allowing to join the analysis of all data layers to integrate the different data base which aid for the identification of the activity of known faults or structures and suggesting the new evidences of active tectonics. A new approach to data integration given by GeoNetGIS capabilities, allow us to create and deliver a wide range of maps, digital

  3. Using geodetic data to infer the kinematic and mechanical properties of deformation sources on Kilauea Volcano, Hawaii

    Science.gov (United States)

    Cervelli, Peter Francis

    2002-09-01

    Paradoxically, one of the greatest hazards associated with oceanic volcanoes is not volcanic. Rather, it is the potential for catastrophic flank failure resulting in devastating tsunamis, which threaten not just the immediate vicinity, but coastal cities along the entire rim of an ocean basin. Kilauea volcano on the Island of Hawaii, USA, a potential source of such flank failures, is monitored by a network of continuously recording geodetic instruments, including Global Positioning System (GPS) receivers, tiltmeters, and strainmeters. In this thesis, methodology is developed for using these geodetic data to estimate the geometry and type of active deformation sources, such as dikes, magma chambers, and faults. The methodology is then applied to two episodes of deformation that occurred at Kilauea Volcano in 1999 and 2000. First, the deformation associated with an earthquake swarm on September 12, 1999 in the Upper East Rift Zone of Kilauea Volcano, which was recorded by continuous GPS receivers, tiltmeters, campaign GPS, leveling, and InSAR, is analyzed and interpreted as a west to east propagating dike intrusion. Lack of premonitory inflation of Kilauea's summit suggests that the immediate cause of the intrusion was probably tensile failure in the shallow crust of the Upper East Rift, rather than forceful magma injection. Second, in early November 2000, the geodetic network recorded transient southeastward displacements, which we interpret as an episode of aseismic fault slip. The duration of the event was about 36 hours; it had an equivalent moment magnitude of M5.7, and a maximum slip velocity of about 6 cm/day. Inversion of the GPS data images a shallowly dipping thrust at a depth of 4.5 km that we interpret as the down dip extension of the Hilina Pali fault system. Thus it is demonstrated that continuous geodetic networks can detect accelerating slip, potentially leading to warnings of imminent volcanic flank collapse. Finally, in the last chapter of the

  4. Previous utilization of service does not improve timely booking in ...

    African Journals Online (AJOL)

    Previous utilization of service does not improve timely booking in antenatal care: Cross sectional study ... Journal Home > Vol 24, No 3 (2010) > ... Results: Past experience on antenatal care service utilization did not come out as a predictor for ...

  5. The Geodetic Seamless Archive Centers Service Layer: A System Architecture for Federating Geodesy Data Repositories

    Science.gov (United States)

    McWhirter, J.; Boler, F. M.; Bock, Y.; Jamason, P.; Squibb, M. B.; Noll, C. E.; Blewitt, G.; Kreemer, C. W.

    2010-12-01

    Three geodesy Archive Centers, Scripps Orbit and Permanent Array Center (SOPAC), NASA's Crustal Dynamics Data Information System (CDDIS) and UNAVCO are engaged in a joint effort to define and develop a common Web Service Application Programming Interface (API) for accessing geodetic data holdings. This effort is funded by the NASA ROSES ACCESS Program to modernize the original GPS Seamless Archive Centers (GSAC) technology which was developed in the 1990s. A new web service interface, the GSAC-WS, is being developed to provide uniform and expanded mechanisms through which users can access our data repositories. In total, our respective archives hold tens of millions of files and contain a rich collection of site/station metadata. Though we serve similar user communities, we currently provide a range of different access methods, query services and metadata formats. This leads to a lack of consistency in the userís experience and a duplication of engineering efforts. The GSAC-WS API and its reference implementation in an underlying Java-based GSAC Service Layer (GSL) supports metadata and data queries into site/station oriented data archives. The general nature of this API makes it applicable to a broad range of data systems. The overall goals of this project include providing consistent and rich query interfaces for end users and client programs, the development of enabling technology to facilitate third party repositories in developing these web service capabilities and to enable the ability to perform data queries across a collection of federated GSAC-WS enabled repositories. A fundamental challenge faced in this project is to provide a common suite of query services across a heterogeneous collection of data yet enabling each repository to expose their specific metadata holdings. To address this challenge we are developing a "capabilities" based service where a repository can describe its specific query and metadata capabilities. Furthermore, the architecture of

  6. Application of ray-traced tropospheric slant delays to geodetic VLBI analysis

    Science.gov (United States)

    Hofmeister, Armin; Böhm, Johannes

    2017-08-01

    The correction of tropospheric influences via so-called path delays is critical for the analysis of observations from space geodetic techniques like the very long baseline interferometry (VLBI). In standard VLBI analysis, the a priori slant path delays are determined using the concept of zenith delays, mapping functions and gradients. The a priori use of ray-traced delays, i.e., tropospheric slant path delays determined with the technique of ray-tracing through the meteorological data of numerical weather models (NWM), serves as an alternative way of correcting the influences of the troposphere on the VLBI observations within the analysis. In the presented research, the application of ray-traced delays to the VLBI analysis of sessions in a time span of 16.5 years is investigated. Ray-traced delays have been determined with program RADIATE (see Hofmeister in Ph.D. thesis, Department of Geodesy and Geophysics, Faculty of Mathematics and Geoinformation, Technische Universität Wien. http://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-3444, 2016) utilizing meteorological data provided by NWM of the European Centre for Medium-Range Weather Forecasts (ECMWF). In comparison with a standard VLBI analysis, which includes the tropospheric gradient estimation, the application of the ray-traced delays to an analysis, which uses the same parameterization except for the a priori slant path delay handling and the used wet mapping factors for the zenith wet delay (ZWD) estimation, improves the baseline length repeatability (BLR) at 55.9% of the baselines at sub-mm level. If no tropospheric gradients are estimated within the compared analyses, 90.6% of all baselines benefit from the application of the ray-traced delays, which leads to an average improvement of the BLR of 1 mm. The effects of the ray-traced delays on the terrestrial reference frame are also investigated. A separate assessment of the RADIATE ray-traced delays is carried out by comparison to the ray-traced delays from the

  7. Space-geodetic Constraints on GIA Models with 3D Viscosity

    Science.gov (United States)

    Van Der Wal, W.; Xu, Z.

    2012-12-01

    Models for Glacial Isostatic Adjustment (GIA) are an important correction to observations of mass change in the polar regions. Inputs for GIA models include past ice thickness and deformation parameters of the Earth's mantle, both of which are imperfectly known. Here we focus on the latter by investigating GIA models with 3D viscosity and composite (linear and non-linear) flow laws. It was found recently that GIA models with a composite flow law result in a better fit to historic sea level data, but they predict too low present-day uplift rates and gravity rates. Here GIA models are fit to space-geodetic constraints in Fennoscandia and North America. The preferred models are used to calculate the magnitude of the GIA correction on mass change estimates in Greenland and Antarctica. The observations used are GRACE Release 4 solutions from CSR and GFZ and published GPS solutions for North America and Fennoscandia, as well as historic sea level data. The GIA simulations are performed with a finite element model of a spherical, self-gravitating, incompressible Earth with 2x2 degree elements. Parameters in the flow laws are taken from seismology, heatflow measurements and experimental constraints and the ice loading history is prescribed by ICE-5G. It was found that GRACE and GPS derived uplift rates agree at the level of 1 mm/year in North America and at a level of 0.5 mm/year in Fennoscandia, the difference between the two regions being due to larger GPS errors and under sampling in North America. It can be concluded that both GPS and GRACE see the same process and the effects of filtering, noise and non-GIA processes such as land hydrology are likely to be small. Two GIA models are found that bring present-day uplift rate close to observed values in North America and Fennoscandia. These models result in a GIA correction of -17 Gt/year and -26 Gt/year on Greenland mass balance estimates from GRACE.

  8. Immersive Virtual Reality Field Trips in the Geosciences: Integrating Geodetic Data in Undergraduate Geoscience Courses

    Science.gov (United States)

    La Femina, P. C.; Klippel, A.; Zhao, J.; Walgruen, J. O.; Stubbs, C.; Jackson, K. L.; Wetzel, R.

    2017-12-01

    High-quality geodetic data and data products, including GPS-GNSS, InSAR, LiDAR, and Structure from Motion (SfM) are opening the doors to visualizing, quantifying, and modeling geologic, tectonic, geomorphic, and geodynamic processes. The integration of these data sets with other geophysical, geochemical and geologic data is providing opportunities for the development of immersive Virtual Reality (iVR) field trips in the geosciences. iVR fieldtrips increase accessibility in the geosciences, by providing experiences that allow for: 1) exploration of field locations that might not be tenable for introductory or majors courses; 2) accessibility to outcrops for students with physical disabilities; and 3) the development of online geosciences courses. We have developed a workflow for producing iVR fieldtrips and tools to make quantitative observations (e.g., distance, area, and volume) within the iVR environment. We use a combination of terrestrial LiDAR and SfM data, 360° photos and videos, and other geophysical, geochemical and geologic data to develop realistic experiences for students to be exposed to the geosciences from sedimentary geology to physical volcanology. We present two of our iVR field trips: 1) Inside the Volcano: Exploring monogenetic volcanism at Thrihnukagigar Iceland; and 2) Changes in Depositional Environment in a Sedimentary Sequence: The Reedsville and Bald Eagle Formations, Pennsylvania. The Thrihnukagigar experience provides the opportunity to investigate monogenetic volcanism through the exploration of the upper 125 m of a fissure-cinder cone eruptive system. Students start at the plate boundary scale, then zoom into a single volcano where they can view the 3D geometry from either terrestrial LiDAR or SfM point clouds, view geochemical data and petrologic thins sections of rock samples, and a presentation of data collection and analysis, results and interpretation. Our sedimentary geology experience is based on a field lab from our

  9. Geodetic Infrastructure in the Ibiza and Barcelona Harbours for Sea Level Monitoring

    Science.gov (United States)

    Martinez-Benjamin, J. J.; Gili, J.; Lopez, R.; Tapia, A.; Perez, B.; Pros, F.

    2013-12-01

    The presentation is directed to the description of the actual situation and relevant information of the geodetic infrastructure of Ibiza and Barcelona sites for sea level determination and contribution to regional sea level rise. Time series are being analysed for mean sea level variations www.puertos.es. .In the framework of a Spanish Space Project, the instrumentation of sea level measurements has been improved by providing the Barcelona site with a radar tide gauge Datamar 2000C from Geonica s.l. near an acoustic tide gauge. Puertos del Estado installed in 2007 a MIROS radar tide gauge and the Barcelona Harbour Authority a GPS referente station in the roof of the new Control Tower situated in the Energy Pier. The radar sensor is over the water surface, on a L-shaped structure which elevates it a few meters above the quay shelf. 1-min data are transmitted to the ENAGAS Control Center by cable and then sent each 1 min to Puertos del Estado by e-mail. There is a GPS station Leica Geosystems GRX1200 GG Pro and antenna 1202. Precision levelling has been made several times in the last two years because the tower is founded in reclaimed land. The measured settlement rate is about 1cm/year that may be could mask the values registered by the tide gauge. A description of the actual infrastructure at Ibiza harbour at Marina de Botafoch, is presented and its applications to sea level monitoring and altimeter calibration in support of the main CGPS at Ibiza harbour. It is described the geometrical precision levelling made in June 2013 between the radar tide gauge and the GPS station. In particular, the CGPS located at Ibiza harbour is essential for its application to the marine campaign Baleares 2013, near Ibiza island. The main objective is to determine the altimeter bias for Jason-2, about 9:09 UTC September 15, 2013, and Saral/AltiKa, about 05:30 UTC September 16, UTC. These activities has been received funding of the Ministerio de Ciencia e Innovacion under Spanish

  10. An accuracy assessment of realtime GNSS time series toward semi- real time seafloor geodetic observation

    Science.gov (United States)

    Osada, Y.; Ohta, Y.; Demachi, T.; Kido, M.; Fujimoto, H.; Azuma, R.; Hino, R.

    2013-12-01

    Large interplate earthquake repeatedly occurred in Japan Trench. Recently, the detail crustal deformation revealed by the nation-wide inland GPS network called as GEONET by GSI. However, the maximum displacement region for interplate earthquake is mainly located offshore region. GPS/Acoustic seafloor geodetic observation (hereafter GPS/A) is quite important and useful for understanding of shallower part of the interplate coupling between subducting and overriding plates. We typically conduct GPS/A in specific ocean area based on repeated campaign style using research vessel or buoy. Therefore, we cannot monitor the temporal variation of seafloor crustal deformation in real time. The one of technical issue on real time observation is kinematic GPS analysis because kinematic GPS analysis based on reference and rover data. If the precise kinematic GPS analysis will be possible in the offshore region, it should be promising method for real time GPS/A with USV (Unmanned Surface Vehicle) and a moored buoy. We assessed stability, precision and accuracy of StarFireTM global satellites based augmentation system. We primarily tested for StarFire in the static condition. In order to assess coordinate precision and accuracy, we compared 1Hz StarFire time series and post-processed precise point positioning (PPP) 1Hz time series by GIPSY-OASIS II processing software Ver. 6.1.2 with three difference product types (ultra-rapid, rapid, and final orbits). We also used difference interval clock information (30 and 300 seconds) for the post-processed PPP processing. The standard deviation of real time StarFire time series is less than 30 mm (horizontal components) and 60 mm (vertical component) based on 1 month continuous processing. We also assessed noise spectrum of the estimated time series by StarFire and post-processed GIPSY PPP results. We found that the noise spectrum of StarFire time series is similar pattern with GIPSY-OASIS II processing result based on JPL rapid orbit

  11. A Unified Geodetic Vertical Velocity Field (UGVVF), Version 1.0

    Science.gov (United States)

    Schmalzle, G.; Wdowinski, S.

    2014-12-01

    Tectonic motion, volcanic inflation or deflation, as well as oil, gas and water pumping can induce vertical motion. In southern California these signals are inter-mingled. In tectonics, properly identifying regions that are contaminated by other signals can be important when estimating fault slip rates. Until recently vertical deformation rates determined by high precision Global Positioning Systems (GPS) had large uncertainties compared to horizontal components and were rarely used to constrain tectonic models of fault motion. However, many continuously occupied GPS stations have been operating for ten or more years, often delivering uncertainties of ~1 mm/yr or less, providing better constraints for tectonic modeling. Various processing centers produced GPS time series and estimated vertical velocity fields, each with their own set of processing techniques and assumptions. We compare vertical velocity solutions estimated by seven data processing groups as well as two combined solutions (Figure 1). These groups include: Central Washington University (CWU) and New Mexico Institute of Technology (NMT), and their combined solution provided by the Plate Boundary Observatory (PBO) through the UNAVCO website. Also compared are the Jet Propulsion Laboratory (JPL) and Scripps Orbit and Permanent Array Center (SOPAC) and their combined solution provided as part of the NASA MEaSUREs project. Smaller velocity fields included are from Amos et al., 2014, processed at the Nevada Geodetic Laboratory, Shen et al., 2011, processed by UCLA and called the Crustal Motion Map 4.0 (CMM4) dataset, and a new velocity field provided by the University of Miami (UM). Our analysis includes estimating and correcting for systematic vertical velocity and uncertainty differences between groups. Our final product is a unified velocity field that contains the median values of the adjusted velocity fields and their uncertainties. This product will be periodically updated when new velocity fields

  12. Books average previous decade of economic misery.

    Science.gov (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  13. Books Average Previous Decade of Economic Misery

    Science.gov (United States)

    Bentley, R. Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20th century since the Depression, we find a strong correlation between a ‘literary misery index’ derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade. PMID:24416159

  14. No discrimination against previous mates in a sexually cannibalistic spider

    Science.gov (United States)

    Fromhage, Lutz; Schneider, Jutta M.

    2005-09-01

    In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.

  15. A Comparison of Geodetic and Geologic Rates Prior to Large Strike-Slip Earthquakes: A Diversity of Earthquake-Cycle Behaviors?

    Science.gov (United States)

    Dolan, James F.; Meade, Brendan J.

    2017-12-01

    Comparison of preevent geodetic and geologic rates in three large-magnitude (Mw = 7.6-7.9) strike-slip earthquakes reveals a wide range of behaviors. Specifically, geodetic rates of 26-28 mm/yr for the North Anatolian fault along the 1999 MW = 7.6 Izmit rupture are ˜40% faster than Holocene geologic rates. In contrast, geodetic rates of ˜6-8 mm/yr along the Denali fault prior to the 2002 MW = 7.9 Denali earthquake are only approximately half as fast as the latest Pleistocene-Holocene geologic rate of ˜12 mm/yr. In the third example where a sufficiently long pre-earthquake geodetic time series exists, the geodetic and geologic rates along the 2001 MW = 7.8 Kokoxili rupture on the Kunlun fault are approximately equal at ˜11 mm/yr. These results are not readily explicable with extant earthquake-cycle modeling, suggesting that they may instead be due to some combination of regional kinematic fault interactions, temporal variations in the strength of lithospheric-scale shear zones, and/or variations in local relative plate motion rate. Whatever the exact causes of these variable behaviors, these observations indicate that either the ratio of geodetic to geologic rates before an earthquake may not be diagnostic of the time to the next earthquake, as predicted by many rheologically based geodynamic models of earthquake-cycle behavior, or different behaviors characterize different fault systems in a manner that is not yet understood or predictable.

  16. Evaluation on the performance of single and dual frequency low cost GPS module observation using geodetic antenna

    Directory of Open Access Journals (Sweden)

    Dedi Atunggal

    2018-06-01

    Full Text Available GPS modules have been used for various applications in recent years. Its early development came in parallel with the advancement of Unmanned Aerial Vehicle (UAV technology. Nowadays, it is also used in in geographic information system (GIS data acquisition/census, mapping surveys, structure stability monitoring systems and many other applications. GPS modules generally have several positioning features, including standard positioning service (SPS, static positioning, precise point positioning (PPP, post processing kinematic (PPK and real time kinematic (RTK GPS. GPS modules in general are only equipped with a microstrip-type antenna or better known as patch antenna. Results from related research show that GPS module with this type of antenna has sub meter accuracy when used for PPK or RTK GPS method. The use of geodetic antennas is very potential to increase GPS position accuracy by up to centimeter level. This paper discusses the evaluation of GPS module measurements with geodetic type antennas for precise positioning using RTK GPS. This paper is focused on the resolution of GPS cycle ambiguity that is often expressed by the term fixing ratio and the accuracy of measurement results obtained. To provide a comprehensive description of the performance of GPS module, in this research two types of GPS module were used; single and dual frequency. Both types of GPS modules were used to conduct simultaneous observation on an open and obstructed observation location.

  17. [Electronic cigarettes - effects on health. Previous reports].

    Science.gov (United States)

    Napierała, Marta; Kulza, Maksymilian; Wachowiak, Anna; Jabłecka, Katarzyna; Florek, Ewa

    2014-01-01

    Currently very popular in the market of tobacco products have gained electronic cigarettes (ang. E-cigarettes). These products are considered to be potentially less harmful in compared to traditional tobacco products. However, current reports indicate that the statements of the producers regarding to the composition of the e- liquids not always are sufficient, and consumers often do not have reliable information on the quality of the product used by them. This paper contain a review of previous reports on the composition of e-cigarettes and their impact on health. Most of the observed health effects was related to symptoms of the respiratory tract, mouth, throat, neurological complications and sensory organs. Particularly hazardous effects of the e-cigarettes were: pneumonia, congestive heart failure, confusion, convulsions, hypotension, aspiration pneumonia, face second-degree burns, blindness, chest pain and rapid heartbeat. In the literature there is no information relating to passive exposure by the aerosols released during e-cigarette smoking. Furthermore, the information regarding to the use of these products in the long term are not also available.

  18. Geodetic constraints on afterslip characteristics following the March 9, 2011, Sanriku-oki earthquake, Japan

    Science.gov (United States)

    Ohta, Yusaku; Hino, Ryota; Inazu, Daisuke; Ohzono, Mako; Ito, Yoshihiro; Mishina, Masaaki; Iinuma, Takeshi; Nakajima, Junichi; Osada, Yukihito; Suzuki, Kensuke; Fujimoto, Hiromi; Tachibana, Kenji; Demachi, Tomotsugu; Miura, Satoshi

    2012-08-01

    A magnitude 7.3 foreshock occurred at the subducting Pacific plate interface on March 9, 2011, 51 h before the magnitude 9.0 Tohoku earthquake off the Pacific coast of Japan. We propose a coseismic and postseismic afterslip model of the magnitude 7.3 event based on a global positioning system network and ocean bottom pressure gauge sites. The estimated coseismic slip and afterslip areas show complementary spatial distributions; the afterslip distribution is located up-dip of the coseismic slip for the foreshock and northward of hypocenter of the Tohoku earthquake. The slip amount for the afterslip is roughly consistent with that determined by repeating earthquake analysis carried out in a previous study. The estimated moment release for the afterslip reached magnitude 6.8, even within a short time period of 51h. A volumetric strainmeter time series also suggests that this event advanced with a rapid decay time constant compared with other typical large earthquakes.

  19. Raw data from orientation studies in crystalline rock areas of the southeastern United States. [Maps, tables of field data and analytical data for sections of North and South Carolina and Georgia, previously reported sites of uranium mineralization

    Energy Technology Data Exchange (ETDEWEB)

    Price, V.

    1976-03-01

    Raw data are presented on orientation studies conducted in crystalline rock areas of the Southeast which were chosen because of published references to uranium mineralization. Preliminary data for four orientation study areas are included. These areas are Lamar County, Georgia; Oconee County, South Carolina; Brush Creek, North Carolina; and North Harper, North Carolina. Sample locality maps, tables of field data, and tables of analytical data are included for each study area. (JGB)

  20. Measurement errors in polymerase chain reaction are a confounding factor for a correct interpretation of 5-HTTLPR polymorphism effects on lifelong premature ejaculation: a critical analysis of a previously published meta-analysis of six studies.

    Science.gov (United States)

    Janssen, Paddy K C; Olivier, Berend; Zwinderman, Aeilko H; Waldinger, Marcel D

    2014-01-01

    To analyze a recently published meta-analysis of six studies on 5-HTTLPR polymorphism and lifelong premature ejaculation (PE). Calculation of fraction observed and expected genotype frequencies and Hardy Weinberg equilibrium (HWE) of cases and controls. LL,SL and SS genotype frequencies of patients were subtracted from genotype frequencies of an ideal population (LL25%, SL50%, SS25%, p = 1 for HWE). Analysis of PCRs of six studies and re-analysis of the analysis and Odds ratios (ORs) reported in the recently published meta-analysis. Three studies deviated from HWE in patients and one study deviated from HWE in controls. In three studies in-HWE the mean deviation of genotype frequencies from a theoretical population not-deviating from HWE was small: LL(1.7%), SL(-2.3%), SS(0.6%). In three studies not-in-HWE the mean deviation of genotype frequencies was high: LL(-3.3%), SL(-18.5%) and SS(21.8%) with very low percentage SL genotype concurrent with very high percentage SS genotype. The most serious PCR deviations were reported in the three not-in-HWE studies. The three in-HWE studies had normal OR. In contrast, the three not-in-HWE studies had a low OR. In three studies not-in-HWE and with very low OR, inadequate PCR analysis and/or inadequate interpretation of its gel electrophoresis resulted in very low SL and a resulting shift to very high SS genotype frequency outcome. Consequently, PCRs of these three studies are not reliable. Failure to note the inadequacy of PCR tests makes such PCRs a confounding factor in clinical interpretation of genetic studies. Currently, a meta-analysis can only be performed on three studies-in-HWE. However, based on the three studies-in-HWE with OR of about 1 there is not any indication that in men with lifelong PE the frequency of LL,SL and SS genotype deviates from the general male population and/or that the SL or SS genotype is in any way associated with lifelong PE.

  1. Measurement errors in polymerase chain reaction are a confounding factor for a correct interpretation of 5-HTTLPR polymorphism effects on lifelong premature ejaculation: a critical analysis of a previously published meta-analysis of six studies.

    Directory of Open Access Journals (Sweden)

    Paddy K C Janssen

    Full Text Available OBJECTIVE: To analyze a recently published meta-analysis of six studies on 5-HTTLPR polymorphism and lifelong premature ejaculation (PE. METHODS: Calculation of fraction observed and expected genotype frequencies and Hardy Weinberg equilibrium (HWE of cases and controls. LL,SL and SS genotype frequencies of patients were subtracted from genotype frequencies of an ideal population (LL25%, SL50%, SS25%, p = 1 for HWE. Analysis of PCRs of six studies and re-analysis of the analysis and Odds ratios (ORs reported in the recently published meta-analysis. RESULTS: Three studies deviated from HWE in patients and one study deviated from HWE in controls. In three studies in-HWE the mean deviation of genotype frequencies from a theoretical population not-deviating from HWE was small: LL(1.7%, SL(-2.3%, SS(0.6%. In three studies not-in-HWE the mean deviation of genotype frequencies was high: LL(-3.3%, SL(-18.5% and SS(21.8% with very low percentage SL genotype concurrent with very high percentage SS genotype. The most serious PCR deviations were reported in the three not-in-HWE studies. The three in-HWE studies had normal OR. In contrast, the three not-in-HWE studies had a low OR. CONCLUSIONS: In three studies not-in-HWE and with very low OR, inadequate PCR analysis and/or inadequate interpretation of its gel electrophoresis resulted in very low SL and a resulting shift to very high SS genotype frequency outcome. Consequently, PCRs of these three studies are not reliable. Failure to note the inadequacy of PCR tests makes such PCRs a confounding factor in clinical interpretation of genetic studies. Currently, a meta-analysis can only be performed on three studies-in-HWE. However, based on the three studies-in-HWE with OR of about 1 there is not any indication that in men with lifelong PE the frequency of LL,SL and SS genotype deviates from the general male population and/or that the SL or SS genotype is in any way associated with lifelong PE.

  2. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    Erna Kinsey

    In the empirical study, a self-administered questionnaire was dis- ... The task of management at all levels in the education system is to create and sustain .... improved school performance (better policies and more innovative fresh ideas);.

  3. Searching for geodetic transient slip signals along the Parkfield segment of the San Andreas Fault

    Science.gov (United States)

    Rousset, B.; Burgmann, R.

    2017-12-01

    The Parkfield section of the San Andreas fault is at the transition between a segment locked since the 1857 Mw 7.9 Fort Tejon earthquake to its south and a creeping segment to the north. It is particularly well instrumented since it is the many previous studies have focused on studying the coseismic and postseismic phases of the two most recent earthquake cycles, the interseismic phase is exhibiting interesting dynamics at the down-dip edge of the seismogenic zone, characterized by a very large number of low frequency earthquakes (LFE) with different behaviors depending on location. Interseismic fault creep rates appear to vary over a wide range of spatial and temporal scales, from the Earth's surface to the base of crust. In this study, we take advantage of the dense Global Positioning System (GPS) network, with 77 continuous stations located within a circle of radius 80 km centered on Parkfield. We correct these time series for the co- and postseismic signals of the 2003 Mw 6.3 San Simeon and 2004 Mw 6.0 Parkfield earthquakes. We then cross-correlate the residual time series with synthetic slow-slip templates following the approach of Rousset et al. (2017). Synthetic tests with transient events contained in GPS time series with realistic noise show the limit of detection of the method. In the application with real GPS time series, the highest correlation amplitudes are compared with micro-seismicity rates, as well as tremor and LFE observations.

  4. INDEXES OF OBESITY AND COMPARISONS WITH PREVIOUS NATIONAL SURVEY DATA IN 9-YEAR-OLD AND 10-YEAR-OLD BLACK-AND-WHITE GIRLS - THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GROWTH AND HEALTH STUDY

    NARCIS (Netherlands)

    CAMPAIGNE, BN; MORRISON, JA; SCHUMANN, BC; FALKNER, F; LAKATOS, E; SPRECHER, D; SCHREIBER, GB

    Objective: To (I) describe anthropometric and body-size measurements in the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) population at baseline and (2) examine potential secular trends in the prevalence of obesity in young black and white girls by comparing NGHS baseline

  5. A previous hamstring injury affects kicking mechanics in soccer players.

    Science.gov (United States)

    Navandar, Archit; Veiga, Santiago; Torres, Gonzalo; Chorro, David; Navarro, Enrique

    2018-01-10

    Although the kicking skill is influenced by limb dominance and sex, how a previous hamstring injury affects kicking has not been studied in detail. Thus, the objective of this study was to evaluate the effect of sex and limb dominance on kicking in limbs with and without a previous hamstring injury. 45 professional players (males: n=19, previously injured players=4, age=21.16 ± 2.00 years; females: n=19, previously injured players=10, age=22.15 ± 4.50 years) performed 5 kicks each with their preferred and non-preferred limb at a target 7m away, which were recorded with a three-dimensional motion capture system. Kinematic and kinetic variables were extracted for the backswing, leg cocking, leg acceleration and follow through phases. A shorter backswing (20.20 ± 3.49% vs 25.64 ± 4.57%), and differences in knee flexion angle (58 ± 10o vs 72 ± 14o) and hip flexion velocity (8 ± 0rad/s vs 10 ± 2rad/s) were observed in previously injured, non-preferred limb kicks for females. A lower peak hip linear velocity (3.50 ± 0.84m/s vs 4.10 ± 0.45m/s) was observed in previously injured, preferred limb kicks of females. These differences occurred in the backswing and leg-cocking phases where the hamstring muscles were the most active. A variation in the functioning of the hamstring muscles and that of the gluteus maximus and iliopsoas in the case of a previous injury could account for the differences observed in the kicking pattern. Therefore, the effects of a previous hamstring injury must be considered while designing rehabilitation programs to re-educate kicking movement.

  6. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    Conclusion: The positive effect of education on oral hygiene practices is highlighted in this study. However there is still need for proper health enlightenment in this population with regards to use of the available oral health care facilities. Keywords: Oral hygiene, Pregnancy, Nigeria. Annals of Ibadan Postgraduate Medicine.

  7. Undergraduate teaching modules featuring geodesy data applied to critical social topics (GETSI: GEodetic Tools for Societal Issues)

    Science.gov (United States)

    Pratt-Sitaula, B. A.; Walker, B.; Douglas, B. J.; Charlevoix, D. J.; Miller, M. M.

    2015-12-01

    The GETSI project, funded by NSF TUES, is developing and disseminating teaching and learning materials that feature geodesy data applied to critical societal issues such as climate change, water resource management, and natural hazards (serc.carleton.edu/getsi). It is collaborative between UNAVCO (NSF's geodetic facility), Mt San Antonio College, and Indiana University. GETSI was initiated after requests by geoscience faculty for geodetic teaching resources for introductory and majors-level students. Full modules take two weeks but module subsets can also be used. Modules are developed and tested by two co-authors and also tested in a third classroom. GETSI is working in partnership with the Science Education Resource Center's (SERC) InTeGrate project on the development, assessment, and dissemination to ensure compatibility with the growing number of resources for geoscience education. Two GETSI modules are being published in October 2015. "Ice mass and sea level changes" includes geodetic data from GRACE, satellite altimetry, and GPS time series. "Imaging Active Tectonics" has students analyzing InSAR and LiDAR data to assess infrastructure earthquake vulnerability. Another three modules are in testing during fall 2015 and will be published in 2016. "Surface process hazards" investigates mass wasting hazard and risk using LiDAR data. "Water resources and geodesy" uses GRACE, vertical GPS, and reflection GPS data to have students investigating droughts in California and the High Great Plains. "GPS, strain, and earthquakes" helps students learn about infinitesimal and coseismic strain through analysis of horizontal GPS data and includes an extension module on the Napa 2014 earthquake. In addition to teaching resources, the GETSI project is compiling recommendations on successful development of geodesy curricula. The chief recommendations so far are the critical importance of including scientific experts in the authorship team and investing significant resources in

  8. Discoveries and Controversies in Geodetic Imaging of Deformation Before and After the M=9 Tohoku-oki Earthquake

    Science.gov (United States)

    Wang, K.; Sun, T.; Hino, R.; Iinuma, T.; Tomita, F.; Kido, M.

    2017-12-01

    Numerous observations pertaining to the M=9.0 2011 Tohoku-oki earthquake have led to new understanding of subduction zone earthquakes. By synthesizing published research results and our own findings, we explore what has been learned about fault behavior and Earth rheology from geodetic imaging of crustal deformation before and after the earthquake. Before the earthquake, megathrust locking models based on land-based geodetic observations correctly outlined the along-strike location of the future rupture zone, showing that land-based observations are capable of resolving along-strike variations in locking and creep at wavelengths comparable to distances from the network. But they predicted a locked zone that was much deeper than the actual rupture in 2011. The incorrect definition of the locking pattern in the dip direction demonstrates not only the need for seafloor geodesy but also the importance of modeling interseismic viscoelastic stress relaxation and stress shadowing. The discovery of decade-long accelerated slip downdip of the future rupture zone raises new questions on fault mechanics. After the earthquake, seafloor geodetic discovery of opposing motion offshore provided unambiguous evidence for the dominance of viscoelastic relaxation in short-term postseismic deformation. There is little deep afterslip in the fault area where the decade-long pre-earthquake slip acceleration is observed. The complementary spatial distribution of pre-slip and afterslip calls for new scientific research. However, the near absence of deep afterslip directly downdip of the main rupture is perceived to be controversial because some viscoelastic models do predict large afterslip here, although less than predicted by purely elastic models. We show that the large afterslip in these models is largely an artefact due to the use of a layered Earth model without a subducting slab. The slab acts as an "anchor" in the mantle and retards landward motion following a subduction earthquake

  9. The predictive effect of fear-avoidance beliefs on low back pain among newly qualified health care workers with and without previous low back pain: a prospective cohort study

    DEFF Research Database (Denmark)

    Jensen, Jette Nygaard; Albertsen, Karen; Borg, Vilhelm

    2009-01-01

    Health care workers have a high prevalence of low back pain (LBP). Although physical exposures in the working environment are linked to an increased risk of LBP, it has been suggested that individual coping strategies, for example fear-avoidance beliefs, could also be important in the development...... and maintenance of LBP. Accordingly, the main objective of this study was to examine (1) the association between physical work load and LBP, (2) the predictive effect of fear-avoidance beliefs on the development of LBP, and (3) the moderating effect of fear-avoidance beliefs on the association between physical...

  10. Impact of the use of autologous stem cell transplantation at first relapse both in naïve and previously rituximab exposed follicular lymphoma patients treated in the GELA/GOELAMS FL2000 study

    Science.gov (United States)

    Le Gouill, Steven; De Guibert, Sophie; Planche, Lucie; Brice, Pauline; Dupuis, Jehan; Cartron, Guillaume; Van Hoof, Achiel; Casasnovas, Olivier; Gyan, Emmanuel; Tilly, Hervé; Fruchart, Christophe; Deconinck, Eric; Fitoussi, Olivier; Gastaud, Lauris; Delwail, Vincent; Gabarre, Jean; Gressin, Rémy; Blanc, Michel; Foussard, Charles; Salles, Gilles

    2011-01-01

    Background We analyzed detailed characteristics and salvage treatment in 175 follicular lymphoma patients from the FL2000 study who were in progression after first-line therapy with or without addition of rituximab to chemotherapy and interferon. Design and Methods The impact of using autologous stem cell transplantation and/or rituximab administration at first progression was investigated, taking into account initial therapy. With a median follow up of 31 months, 3-year event free and overall survival rates after progression were 50% (95%CI 42–58%) and 72% (95%CI 64–78%), respectively. Results The 3-year event free rate of rituximab re-treated patients (n=112) was 52% (95%CI 41–62%) versus 40% (95%CI 24–55%) for those not receiving rituximab second line (n=53) (P=0.075). There was a significant difference in 3-year overall survival between patients receiving autologous stem cell transplantation and those not: 92% (95%CI 78–97%) versus 63% (95%CI 51–72%) (P=0.0003), respectively. In multivariate analysis, both autologous stem cell transplantation and period of progression/relapse affected event free and overall survival. Conclusions Regardless of front-line rituximab exposure, this study supports incorporating autologous stem cell transplantation in the therapeutic approach at first relapse for follicular lymphoma patients. PMID:21486862

  11. Twelve-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg and 400/10 microg combination treatments in patients with persistent asthma previously receiving high-dose inhaled corticosteroids

    DEFF Research Database (Denmark)

    Weinstein, Steven F; Corren, Jonathan; Murphy, Kevin

    2010-01-01

    A significant unmet medical need exists in patients with uncontrolled asthma. The purpose of this study was to evaluate the efficacy and safety of mometasone furoate/formoterol (MF/F) 400/10 microg versus MF 400 microg administered twice-daily (b.i.d.) via metered-dose inhaler in patients...... with asthma uncontrolled on high-dose inhaled corticosteroids (ICS). In a 12-week, randomized, multicenter, double-blind, parallel-group study, patients (>or=12 years of age) were randomized to MF/F 200/10 microg, MF/F 400/10 microg, or MF 400 microg, b.i.d. after a 2- to 3-week open-label run in with MF 400...... microg b.i.d. The primary end point was mean change in area under the curve from 0 to 12 hours in forced expiratory volume in 1 second (FEV(1) AUC(0-12h)) from baseline to week 12 for MF/F 400/10 microg versus MF 400 microg. Effects of MF/F on asthma control and symptoms were evaluated and adverse events...

  12. Local recurrence risk after previous salvage mastectomy.

    Science.gov (United States)

    Tanabe, M; Iwase, T; Okumura, Y; Yoshida, A; Masuda, N; Nakatsukasa, K; Shien, T; Tanaka, S; Komoike, Y; Taguchi, T; Arima, N; Nishimura, R; Inaji, H; Ishitobi, M

    2016-07-01

    Breast-conserving surgery is a standard treatment for early breast cancer. For ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery, salvage mastectomy is the current standard surgical procedure. However, it is not rare for patients with IBTR who have received salvage mastectomy to develop local recurrence. In this study, we examined the risk factors of local recurrence after salvage mastectomy for IBTR. A total of 118 consecutive patients who had histologically confirmed IBTR without distant metastases and underwent salvage mastectomy without irradiation for IBTR between 1989 and 2008 were included from eight institutions in Japan. The risk factors of local recurrence were assessed. The median follow-up period from salvage mastectomy for IBTR was 4.6 years. Patients with pN2 or higher on diagnosis of the primary tumor showed significantly poorer local recurrence-free survival than those with pN0 or pN1 at primary tumor (p mastectomy for IBTR. Further research and validation studies are needed. (UMIN-CTR number UMIN000008136). Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Barbara Daly

    2018-01-01

    Full Text Available Gestational diabetes mellitus (GDM is associated with developing type 2 diabetes, but very few studies have examined its effect on developing cardiovascular disease.We conducted a retrospective cohort study utilizing a large primary care database in the United Kingdom. From 1 February 1990 to 15 May 2016, 9,118 women diagnosed with GDM were identified and randomly matched with 37,281 control women by age and timing of pregnancy (up to 3 months. Adjusted incidence rate ratios (IRRs with 95% confidence intervals (CIs were calculated for cardiovascular risk factors and cardiovascular disease. Women with GDM were more likely to develop type 2 diabetes (IRR = 21.96; 95% CI 18.31-26.34 and hypertension (IRR = 1.85; 95% CI 1.59-2.16 after adjusting for age, Townsend (deprivation quintile, body mass index, and smoking. For ischemic heart disease (IHD, the IRR was 2.78 (95% CI 1.37-5.66, and for cerebrovascular disease 0.95 (95% CI 0.51-1.77; p-value = 0.87, after adjusting for the above covariates and lipid-lowering medication and hypertension at baseline. Follow-up screening for type 2 diabetes and cardiovascular risk factors was poor. Limitations include potential selective documentation of severe GDM for women in primary care, higher surveillance for outcomes in women diagnosed with GDM than control women, and a short median follow-up postpartum period, with a small number of outcomes for IHD and cerebrovascular disease.Women diagnosed with GDM were at very high risk of developing type 2 diabetes and had a significantly increased incidence of hypertension and IHD. Identifying this group of women in general practice and targeting cardiovascular risk factors could improve long-term outcomes.

  14. Interseismic and coseismic surface deformation deduced from space geodetic observations : with inferences on seismic hazard, tectonic processes, earthquake complexity, and slip distribution

    NARCIS (Netherlands)

    Bos, A.G. (Annemarie Gerredina)

    2003-01-01

    In this thesis I am concerned with modeling the kinematics of surface deformation using space geodetic observations in order to advance insight in both interseismic and coseismic surface response. To model the surface deformation field I adopt the method of Spakman and Nyst (2002) which resolves the

  15. Short-and long-term effects of discharged OBM cuttings, with and without previous washing, tested in field and laboratory studies on the Dutch continental shelf, 1985-1990

    International Nuclear Information System (INIS)

    De Jong, A.; Zevenboom, W.; Van Het Groenewoud, H.; Daan, R.

    1991-01-01

    This paper reports on a Dutch programme that was carried out to study the distribution of discharged washed and unwashed oil-containing cuttings in the sediment and waterphase and their effects on selected test species in the Dutch part of the North Sea. The distribution of OBM cuttings in sediment around drilling locations was related to the total amount of oil discharged in the watercolumn. Increased oil contents were found over a range of 1000 to 5000 m in residual current direction. Total oil contents remained high at locations where unwashed OBM cuttings were discharged. At one location oil was found in high concentrations up to 6 years after discharge of OBM cuttings, especially due to the persistence of the oil fractions Other peaks and UCM. Washing of OBM cuttings resulted in lower amounts of oil discharged, lower concentrations in the sediment in the vicinity of the platform (up to 100 m), equal concentrations at 250 m but higher concentrations up to at more than 500 m off the platform when compared with unwashed cuttings and the respective amount of oil discharged. However, within one year, degradation of oil seems to have taken place at one of the washed sites at 5000 m. During discharge in the watercolumn, oil was taken up by Mytilus edulis from washed cuttings as well as from unwashed cuttings. Leaching of oil from the sediment into the waterphase was measurable in the field for only a limited period to time, less than a year after discharge. Several sediment-inhabiting species were tested on their response to oil contamination. Four species tested in experimental boxcosm set-ups, Echinocardium cordatum, Amphiura filiformis, Lagis koreni and Nucula turgida responded to elevated contamination levels by increased mortality

  16. Endoscopic Third Ventriculostomy in Previously Shunted Children

    Directory of Open Access Journals (Sweden)

    Eva Brichtova

    2013-01-01

    Full Text Available Endoscopic third ventriculostomy (ETV is a routine and safe procedure for therapy of obstructive hydrocephalus. The aim of our study is to evaluate ETV success rate in therapy of obstructive hydrocephalus in pediatric patients formerly treated by ventriculoperitoneal (V-P shunt implantation. From 2001 till 2011, ETV was performed in 42 patients with former V-P drainage implantation. In all patients, the obstruction in aqueduct or outflow parts of the fourth ventricle was proved by MRI. During the surgery, V-P shunt was clipped and ETV was performed. In case of favourable clinical state and MRI functional stoma, the V-P shunt has been removed 3 months after ETV. These patients with V-P shunt possible removing were evaluated as successful. In our group of 42 patients we were successful in 29 patients (69%. There were two serious complications (4.7%—one patient died 2.5 years and one patient died 1 year after surgery in consequence of delayed ETV failure. ETV is the method of choice in obstructive hydrocephalus even in patients with former V-P shunt implantation. In case of acute or scheduled V-P shunt surgical revision, MRI is feasible, and if ventricular system obstruction is diagnosed, the hydrocephalus may be solved endoscopically.

  17. Ultrasound screening of thyroid nodules in adults with no previous exposed to irradiation comparison between scanning, palpation and fine needle aspiration cytology. A study in Ghaem Hospital, Mashhad, North East of Iran

    International Nuclear Information System (INIS)

    Rahrouh, M.; Namadanian, G.R.; Zakavi, S.R.; Rezaei, H.

    2003-01-01

    There are a great number of studies on the association between childhood radiation exposure and thyroid nodules and cancer. Ultrasound imaging of thyroid nodules is valuable part of diagnostics and identifies abnormalities, because ultrasound can detect nodules as small as 2-3 mm and no radiation is involved , it has gained wide acceptance for the screening of nodular thyroid disease. 500 subjects were selected randomly from medical students in university of medical sciences in Mashhad North East of Iran. Individuals were screened by a health survey , thyroid ultrasounds, 99mTc-pertechnetate scans, palpation and fine needle aspiration obtained as necessary. The ultrasound was performed with a 7.5-MHz transducer in direct contact with the lubricated skin of the extended neck. Each ultrasound exam was read independently by two radiologists and one endocrinologist. Each nodule was characterized as follows: 1) presence; 2) size ; 3) location; ant or post; 4) location; upper pole, midportion of lobe, lower pole, or isthmus; and 5) type; solid, cystic, or mixed. In 500 cases (312 men, 188 women; age range, 18 - 30 years) underwent neck sonography. Normal findings were verified by clinical follow-up and thyroid disease was found in (5%) of subjectes. A total of 25 certain thyroid nodules were detected by the ultrasound examinations. Eighty eight percent nodules were less than 1.0 cm dimension.Among the subjects who had them thyroid nodules,(48%) were cystic , (44%) were hypoechoic lesions and (8 %) were hyperechoic .The abnormality of thyroid echo was solitary in (1,8%) ,multiple in (1,4%) and diffuse in (0,6%) of subjectes. All abnormal findings were verified by fine needle aspiration biopsy and correlated with thyroid scan, and surgery. The results reported here can be compared to several reports on the prevalence of ultrasound detected thyroid nodules in adult populations not exposed to radiation .The major advantage is that ultrasound can find clinically important

  18. Research Article. Geodesic equations and their numerical solutions in geodetic and Cartesian coordinates on an oblate spheroid

    Directory of Open Access Journals (Sweden)

    Panou G.

    2017-02-01

    Full Text Available The direct geodesic problem on an oblate spheroid is described as an initial value problem and is solved numerically using both geodetic and Cartesian coordinates. The geodesic equations are formulated by means of the theory of differential geometry. The initial value problem under consideration is reduced to a system of first-order ordinary differential equations, which is solved using a numerical method. The solution provides the coordinates and the azimuths at any point along the geodesic. The Clairaut constant is not used for the solution but it is computed, allowing to check the precision of the method. An extensive data set of geodesics is used, in order to evaluate the performance of the method in each coordinate system. The results for the direct geodesic problem are validated by comparison to Karney’s method. We conclude that a complete, stable, precise, accurate and fast solution of the problem in Cartesian coordinates is accomplished.

  19. Crustal Deformation across the Jericho Valley Section of the Dead Sea Fault as Resolved by Detailed Field and Geodetic Observations

    Science.gov (United States)

    Hamiel, Yariv; Piatibratova, Oksana; Mizrahi, Yaakov; Nahmias, Yoav; Sagy, Amir

    2018-04-01

    Detailed field and geodetic observations of crustal deformation across the Jericho Fault section of the Dead Sea Fault are presented. New field observations reveal several slip episodes that rupture the surface, consist with strike slip and extensional deformation along a fault zone width of about 200 m. Using dense Global Positioning System measurements, we obtain the velocities of new stations across the fault. We find that this section is locked for strike-slip motion with a locking depth of 16.6 ± 7.8 km and a slip rate of 4.8 ± 0.7 mm/year. The Global Positioning System measurements also indicate asymmetrical extension at shallow depths of the Jericho Fault section, between 0.3 and 3 km. Finally, our results suggest the vast majority of the sinistral slip along the Dead Sea Fault in southern Jorden Valley is accommodated by the Jericho Fault section.

  20. How Well do we Know Near-Surface Density When Determining Mass Balance by the Geodetic Method?

    Science.gov (United States)

    Kuhn, M. H.; Matzi, E.

    2005-12-01

    From a data set of firn pits in the accumulation area of Hintereisferner in the years 1964 - 2002 the behavior of density and water equivalent was analyzed with a view to estimating the potential errors in the application of the geodetic method. Since annual specific balance ranged from 100 to 3300 mm w.e. the profiles were scaled to total depth. For the uppermost 10% of the annual deposit at a typical location the 1964-2002 mean density would be 350 kg/m-3 with a standard deviation of 110 kg/m-3; for the 10% layer at the base of the annual snowpack the respective figures are 510 +- 30 kg/m-3. The normalized long term means of an ensemble of 9 pits ranged from 310 to 380 kg/m-3 in the top layer and from 510 to 540 kg/m-3 in the bottom layer. When one outlier is removed the the range in the bottom layer reduces to 525 to 540 kg/m-3. This small local variance encourages the use of the geodetic method. The comparison of elevation models of 1969 and 1997 yields a mass change that agrees very well with the results of the glaciological method provided the volume change is converted to mass with a density of 900 kg/m-3. While this may be true for the entire glacier on long terms, it will fail for individual years in the accumulation area. Possible errors are calculated from the data set emphasizing the role of year to year changes of specific balance and accumulation area ratio.

  1. Influence of previous knowledge in Torrance tests of creative thinking

    OpenAIRE

    Aranguren, María; Consejo Nacional de Investigaciones Científicas y Técnicas CONICET

    2015-01-01

    The aim of this work is to analyze the influence of study field, expertise and recreational activities participation in Torrance Tests of Creative Thinking (TTCT, 1974) performance. Several hypotheses were postulated to explore the possible effects of previous knowledge in TTCT verbal and TTCT figural university students’ outcomes. Participants in this study included 418 students from five study fields: Psychology;Philosophy and Literature, Music; Engineering; and Journalism and Advertisin...

  2. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    The aim of this study was to identify influences on the job satisfaction of previously disadvantaged ..... I am still riding the cloud … I hope it lasts. .... as a way of creating a climate and culture in schools where individuals are willing to explore.

  3. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    The aim of this study was to identify influences on the job satisfaction of previously disadvantaged school principals in North-West Province. Evans's theory of job satisfaction, morale and motivation was useful as a conceptual framework. A mixedmethods explanatory research design was important in discovering issues with ...

  4. Abiraterone in metastatic prostate cancer without previous chemotherapy

    NARCIS (Netherlands)

    Ryan, Charles J.; Smith, Matthew R.; de Bono, Johann S.; Molina, Arturo; Logothetis, Christopher J.; de Souza, Paul; Fizazi, Karim; Mainwaring, Paul; Piulats, Josep M.; Ng, Siobhan; Carles, Joan; Mulders, Peter F. A.; Basch, Ethan; Small, Eric J.; Saad, Fred; Schrijvers, Dirk; van Poppel, Hendrik; Mukherjee, Som D.; Suttmann, Henrik; Gerritsen, Winald R.; Flaig, Thomas W.; George, Daniel J.; Yu, Evan Y.; Efstathiou, Eleni; Pantuck, Allan; Winquist, Eric; Higano, Celestia S.; Taplin, Mary-Ellen; Park, Youn; Kheoh, Thian; Griffin, Thomas; Scher, Howard I.; Rathkopf, Dana E.; Boyce, A.; Costello, A.; Davis, I.; Ganju, V.; Horvath, L.; Lynch, R.; Marx, G.; Parnis, F.; Shapiro, J.; Singhal, N.; Slancar, M.; van Hazel, G.; Wong, S.; Yip, D.; Carpentier, P.; Luyten, D.; de Reijke, T.

    2013-01-01

    Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic castration-resistant prostate cancer after chemotherapy. We evaluated this agent in patients who had not received previous chemotherapy. In this double-blind study, we randomly assigned

  5. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2012-01-31

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  6. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2011-01-01

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  7. [Population policy and women: the relevance of previous studies].

    Science.gov (United States)

    De Barbieri, M T

    1983-01-01

    Although Mexico has had high rates of population growth since the 1930s caused by continuing high fertility but declining infant and general mortality, and has undergone deep structural change including declining agricultural production, rapid industrialization, urbanization, and increasing urban umemployment, it was not until the 1970s that the government began to adopt measures aimed at controlling population growth. Opponents of family planning argued that economic and social development would lead to fertility decline, but its proponents believed that reducing population growth would free resources for productive investment that otherwise would have to be used to finance services for the ever-growing population. At the same time that the constitution and laws were changed to allow or promote family planning, Mexican civil and labor laws were changed to provide for equality of men and women. Some background is necessary to understand the effect of such changes in the role and status of the Mexican woman. A relationship has been noted between demographic models--the form in which a society reproduces over a given time--and the social condition of women. Women have generally been subordinated to men during known history, but recent research indicates that their history has not been as uniform as once supposed. The particular form in which each society defines the natural-biological basis of sex roles varies; social definitions of sex and gender vary depending on the extension of "natural-biological" character to specific areas and tasks. The cases of French women in the 16th-18th centuries and German women under Hitler illustrate different ways in which demographic models and the condition of women have varied within a general framework of subordination of women. But when attempts are made to change a given demographic model, the condition of women is redefined at the level of practice as well as of value orientations concerning motherhood, female labor force participation, and the role of women in society. Moreover, the literature concerning fertility decline contains numerous statements by both those opposed to and in favor of birth control, that improving the status of women is 1 of the most effective means of reducing population growth. It can then be asked what changes in the role of women in Mexico will attend application of a fertility reduction policy. The crude birth rate declined from 44.2 in 1970 to 34.4 in 1980, with fertility falling among all age groups but especially among women over 40. The decline occurred primarily among urban nonmanual occupations. More research must be done on recent fertility change in Mexico and on related changes in the role orientations of men and women in different classes and life cycle stages, that have occurred at various stages of the population debate.

  8. Determination of recent horizontal crustal movements and deformations of African and Eurasian plates in western Mediterranean region using geodetic-GPS computations extended to 2006 (from 1997) related to NAFREF and AFREF frames.

    Science.gov (United States)

    Azzouzi, R.

    2009-04-01

    Determination of recent horizontal crustal movements and deformations of African and Eurasian plates in western Mediterranean region using geodetic-GPS computations extended to 2006 (from 1997) related to NAFREF and AFREF frames. By: R. Azzouzi*, M. Ettarid*, El H. Semlali*, et A. Rimi+ * Filière de Formation en Topographie Institut Agronomique et Vétérinaire Hassan II B.P. 6202 Rabat-Instituts MAROC + Département de la Physique du Globe Université Mohammed V Rabat MAROC This study focus on the use of the geodetic spatial technique GPS for geodynamic purposes generally in the Western Mediterranean area and particularly in Morocco. It aims to exploit this technique first to determine the geodetic coordinates on some western Mediterranean sites. And also this technique is used to detect and to determine movements cross the boundary line between the two African and Eurasian crustal plates on some well chosen GPS-Geodynamics sites. It will allow us also to estimate crustal dynamic parameters of tension that results. These parameters are linked to deformations of terrestrial crust in the region. They are also associated with tectonic constraints of the study area. The usefulness of repeated measurements of these elements, the estimate of displacements and the determination of their temporal rates is indisputable. Indeed, sismo-tectonique studies allow a good knowledge of the of earthquake processes, their frequency their amplitude and even of their prediction in the world in general and in Moroccan area especially. They allow also contributing to guarantee more security for all most important management projects, as projects of building great works (dams, bridges, nuclear centrals). And also as preliminary study, for the most important joint-project between Europe and Africa through the Strait of Gibraltar. For our application, 23 GPS monitoring stations under the ITRF2000 reference frame are chosen in Eurasian and African plates. The sites are located around the

  9. Seismic and geodetic signatures of fault slip at the Slumgullion Landslide Natural Laboratory

    Science.gov (United States)

    Gomberg, J.; Schulz, W.; Bodin, P.; Kean, J.

    2011-01-01

    We tested the hypothesis that the Slumgullion landslide is a useful natural laboratory for observing fault slip, specifically that slip along its basal surface and side-bounding strike-slip faults occurs with comparable richness of aseismic and seismic modes as along crustal- and plate-scale boundaries. Our study provides new constraints on models governing landslide motion. We monitored landslide deformation with temporary deployments of a 29-element prism array surveyed by a robotic theodolite and an 88-station seismic network that complemented permanent extensometers and environmental instrumentation. Aseismic deformation observations show that large blocks of the landslide move steadily at approximately centimeters per day, possibly punctuated by variations of a few millimeters, while localized transient slip episodes of blocks less than a few tens of meters across occur frequently. We recorded a rich variety of seismic signals, nearly all of which originated outside the monitoring network boundaries or from the side-bounding strike-slip faults. The landslide basal surface beneath our seismic network likely slipped almost completely aseismically. Our results provide independent corroboration of previous inferences that dilatant strengthening along sections of the side-bounding strike-slip faults controls the overall landslide motion, acting as seismically radiating brakes that limit acceleration of the aseismically slipping basal surface. Dilatant strengthening has also been invoked in recent models of transient slip and tremor sources along crustal- and plate-scale faults suggesting that the landslide may indeed be a useful natural laboratory for testing predictions of specific mechanisms that control fault slip at all scales.

  10. Response to health insurance by previously uninsured rural children.

    Science.gov (United States)

    Tilford, J M; Robbins, J M; Shema, S J; Farmer, F L

    1999-08-01

    To examine the healthcare utilization and costs of previously uninsured rural children. Four years of claims data from a school-based health insurance program located in the Mississippi Delta. All children who were not Medicaid-eligible or were uninsured, were eligible for limited benefits under the program. The 1987 National Medical Expenditure Survey (NMES) was used to compare utilization of services. The study represents a natural experiment in the provision of insurance benefits to a previously uninsured population. Premiums for the claims cost were set with little or no information on expected use of services. Claims from the insurer were used to form a panel data set. Mixed model logistic and linear regressions were estimated to determine the response to insurance for several categories of health services. The use of services increased over time and approached the level of utilization in the NMES. Conditional medical expenditures also increased over time. Actuarial estimates of claims cost greatly exceeded actual claims cost. The provision of a limited medical, dental, and optical benefit package cost approximately $20-$24 per member per month in claims paid. An important uncertainty in providing health insurance to previously uninsured populations is whether a pent-up demand exists for health services. Evidence of a pent-up demand for medical services was not supported in this study of rural school-age children. States considering partnerships with private insurers to implement the State Children's Health Insurance Program could lower premium costs by assembling basic data on previously uninsured children.

  11. Multi-scale model of the ionosphere from the combination of modern space-geodetic satellite techniques - project status and first results

    Science.gov (United States)

    Schmidt, M.; Hugentobler, U.; Jakowski, N.; Dettmering, D.; Liang, W.; Limberger, M.; Wilken, V.; Gerzen, T.; Hoque, M.; Berdermann, J.

    2012-04-01

    Near real-time high resolution and high precision ionosphere models are needed for a large number of applications, e.g. in navigation, positioning, telecommunications or astronautics. Today these ionosphere models are mostly empirical, i.e., based purely on mathematical approaches. In the DFG project 'Multi-scale model of the ionosphere from the combination of modern space-geodetic satellite techniques (MuSIK)' the complex phenomena within the ionosphere are described vertically by combining the Chapman electron density profile with a plasmasphere layer. In order to consider the horizontal and temporal behaviour the fundamental target parameters of this physics-motivated approach are modelled by series expansions in terms of tensor products of localizing B-spline functions depending on longitude, latitude and time. For testing the procedure the model will be applied to an appropriate region in South America, which covers relevant ionospheric processes and phenomena such as the Equatorial Anomaly. The project connects the expertise of the three project partners, namely Deutsches Geodätisches Forschungsinstitut (DGFI) Munich, the Institute of Astronomical and Physical Geodesy (IAPG) of the Technical University Munich (TUM) and the German Aerospace Center (DLR), Neustrelitz. In this presentation we focus on the current status of the project. In the first year of the project we studied the behaviour of the ionosphere in the test region, we setup appropriate test periods covering high and low solar activity as well as winter and summer and started the data collection, analysis, pre-processing and archiving. We developed partly the mathematical-physical modelling approach and performed first computations based on simulated input data. Here we present information on the data coverage for the area and the time periods of our investigations and we outline challenges of the multi-dimensional mathematical-physical modelling approach. We show first results, discuss problems

  12. Geodetic glacier mass balances at the push of a button: application of Structure from Motion technology on aerial images in mountain regions

    Science.gov (United States)

    Bolch, T.; Mölg, N.

    2017-12-01

    The application of Structure-from-Motion (SfM) to generate digital terrain models (DTMs) derived out of images from various kinds of sources has strongly increased in recent years. The major reason for this is its easy-to-use handling in comparison to conventional photogrammetry. In glaciology, DTMs are intensely used, among others, to calculate the geodetic mass balances. Few studies investigated the application of SfM to aerial images in mountainous terrain and results look promising. We tested this technique in a demanding environment in the Swiss Alps including very steep slopes, snow and ice covered terrain. SfM (using the commercial software packages of Agisoft Photoscan and Pix4DMapper) and conventional photogrammetry (ERDAS Photogrammetry) were applied on archival aerial images for nine dates between 1946 and 2005 the results were compared regarding bundle adjustment and final DTM quality. The overall precision of the DTMs could be defined with the use of a modern, high-quality reference DTM by Swisstopo. Results suggest a high performance of SfM to produce DTMs of similar quality as conventional photogrammetry. A ground resolution of high quality (little noise and artefacts) can be up to 50% higher, with 3-6 times less user effort. However, the controls on the commercial SfM software packages are limited in comparison to ERDAS Photogrammetry. SfM performs less reliably when few images with little overlap are processed. Overall, the uncertainty of DTMs from the different software are comparable and mostly within the uncertainty range of the reference DTM, making them highly valuable for glaciological purposes. Even though SfM facilitates the largely automated production of high quality DTMs, the user is not exempt from a thorough quality check, at best with reference data where available.

  13. Geodetic characteristic of the postseismic deformation following the interplate large earthquake along the Japan Trench (Invited)

    Science.gov (United States)

    Ohta, Y.; Hino, R.; Ariyoshi, K.; Matsuzawa, T.; Mishina, M.; Sato, T.; Inazu, D.; Ito, Y.; Tachibana, K.; Demachi, T.; Miura, S.

    2013-12-01

    On March 9, 2011 at 2:45 (UTC), an M7.3 interplate earthquake (hereafter foreshock) occurred ~45 km northeast of the epicenter of the M9.0 2011 Tohoku earthquake. This foreshock preceded the 2011 Tohoku earthquake by 51 hours. Ohta et al., (2012, GRL) estimated co- and postseismic afterslip distribution based on a dense GPS network and ocean bottom pressure gauge sites. They found the afterslip distribution was mainly concentrated in the up-dip extension of the coseismic slip. The coseismic slip and afterslip distribution of the foreshock were also located in the slip deficit region (between 20-40m slip) of the coiseismic slip of the M9.0 mainshock. The slip amount for the afterslip is roughly consistent with that determined by repeating earthquake analysis carried out in a previous study (Kato et al., 2012, Science). The estimated moment release for the afterslip reached magnitude 6.8, even within a short time period of 51 hours. They also pointed out that a volumetric strainmeter time series suggests that this event advanced with a rapid decay time constant (4.8 h) compared with other typical large earthquakes. The decay time constant of the afterslip may reflect the frictional property of the plate interface, especially effective normal stress controlled by fluid. For verification of the short decay time constant of the foreshock, we investigated the postseismic deformation characteristic following the 1989 and 1992 Sanriku-Oki earthquakes (M7.1 and M6.9), 2003 and 2005 Miyagi-Oki earthquakes (M6.8 and M7.2), and 2008 Fukushima-Oki earthquake (M6.9). We used four components extensometer at Miyako (39.59N, 141.98E) on the Sanriku coast for 1989 and 1992 event. For 2003, 2005 and 2008 events, we used volumetric strainmeter at Kinka-zan (38.27N, 141.58E) and Enoshima (38.27N, 141.60E). To extract the characteristics of the postseismic deformation, we fitted the logarithmic function. The estimated decay time constants for each earthquake had almost similar range (1

  14. Gnss Geodetic Monitoring as Support of Geodynamics Research in Colombia, South America

    Science.gov (United States)

    Mora-Paez, H.; Acero-Patino, N.; Rodriguez-Zuluaga, J. S.; Diederix, H.; Bohorquez-Orozco, O. P.; Martinez-Diaz, G. P.; Diaz-Mila, F.; Giraldo-Londono, L. S.; Cardozo-Giraldo, S.; Vasquez-Ospina, A. F.; Lizarazo, S. C.

    2013-05-01

    To support the geodynamics research at the northwestern corner of South America, GEORED, the acronym for "Geodesia: Red de Estudios de Deformación" has been adopted for the Project "Implementation of the National GNSS Network for Geodynamics" carried out by the Colombian Geological Survey, (SGC), formerly INGEOMINAS. Beginning in 2007, discussions within the GEORED group led to a master plan for the distribution of the base permanent GPS/GNSS station array and specific areas of interest for campaign site construction. The use of previously identified active faults as preferred structures along which stresses are transferred through the deformational area led to the idea of segmentation of the North Andes within Colombia into 20 tectonic sub-blocks. Each of the 20 sub-blocks is expected to have, at least, three-four permanent GPS/GNSS stations within the block along with construction of campaign sites along the boundaries. Currently, the GEORED Network is managing 46 continuously including: 40 GEORED GPS/GNSS continuously operating stations; 4 GNSS continuously operating stations provided by the COCONet (Continuously Operating Caribbean GPS Observational Network) Project; the Bogotá IGS GPS station (BOGT), installed in 1994 under the agreement between JPL-NASA and the SGC; and the San Andres Island station, installed in 2007 under the MOU between UCAR and the SGC. In addition to the permanent installations, more than 230 GPS campaign sites have been constructed and are being occupied one time per year. The Authority of the Panama Canal and the Escuela Politecnica de Quito have also provided data of 4 and 5 GPS/GNSS stations respectively. The GPS data are processed using the GIPSY-OASIS II software, and the GPS time series of daily station positions give fundamental information for both regional and local geodynamics studies. Until now, we have obtained 100 quality vector velocities for Colombia, 23 of them as part of the permanent network. The GPS/GNSS stations

  15. Challenging previous conceptions of vegetarianism and eating disorders.

    Science.gov (United States)

    Fisak, B; Peterson, R D; Tantleff-Dunn, S; Molnar, J M

    2006-12-01

    The purpose of this study was to replicate and expand upon previous research that has examined the potential association between vegetarianism and disordered eating. Limitations of previous research studies are addressed, including possible low reliability of measures of eating pathology within vegetarian samples, use of only a few dietary restraint measures, and a paucity of research examining potential differences in body image and food choice motives of vegetarians versus nonvegetarians. Two hundred and fifty-six college students completed a number of measures of eating pathology and body image, and a food choice motives questionnaire. Interestingly, no significant differences were found between vegetarians and nonvegetarians in measures of eating pathology or body image. However, significant differences in food choice motives were found. Implications for both researchers and clinicians are discussed.

  16. Permanent terrestrial geodetic system for monitoring the stability of the 2007 Lava Fan in the Sciara de Fuoco (Stromboli volcano, Italy)

    Science.gov (United States)

    Bonforte, A.; Cantarero, M.; Puglisi, G.; Spata, A.

    2009-04-01

    At the end of the 2002-2003 eruption, a terrestrial monitoring system was installed for routinely measuring the movements of benchmarks installed inside the Sciara del Fuoco (hereafter SdF) (Puglisi et al., 2005). This system, named THEODOROS, is based on a remotely controlled robotized Total Station installed near Punta Labronzo, on the northern border of the SdF. The 2007 eruption caused a dramatic change in the operations of THEODOROS. The 2007 lava flows, indeed, destroyed all benchmarks installed on the northern part of the SdF, leaving only those on its central part. This eruption produced a lava fan at the base of the SdF, due to the rapid cooling of the lava flows when entering into the sea. the continuous overlapping of several flows during the eruption, indeed, build a thick lava body (the fan); it was emplaced on a very steep slope, partially originated during the landslides occurred on December 2002, producing an hazard condition due to the possible fast sliding of this fan into the sea. In order to monitor the stability of this lava fan, a new terrestrial geodetic network, was implemented on 6 April 2007, by installing 5 reflectors along a profile crossing the lava body, approximately over the old coastline. Later on, in June 2007, 4 further reflectors were installed at higher and lower altitude with respect to the previous profile, to obtain more information on the overall deformation of the lava body. Measurements were rather noisy during the first months, but a better definition of the reference system strongly improved the quality of the data. The position of the 9 benchmarks over the lava fan allows the areal distribution of the deformation to be drawn. The measurements carried out every 10 minutes allow us to follow with high temporal detail their motion. The data collected since the end of the eruption highlighted a significant downslope motion of the entire lava fan, decreasing from the South to the North, where the body is buttressed by the

  17. Geostatistical Investigations of Displacements on the Basis of Data from the Geodetic Monitoring of a Hydrotechnical Object

    Science.gov (United States)

    Namysłowska-Wilczyńska, Barbara; Wynalek, Janusz

    2017-12-01

    Geostatistical methods make the analysis of measurement data possible. This article presents the problems directed towards the use of geostatistics in spatial analysis of displacements based on geodetic monitoring. Using methods of applied (spatial) statistics, the research deals with interesting and current issues connected to space-time analysis, modeling displacements and deformations, as applied to any large-area objects on which geodetic monitoring is conducted (e.g., water dams, urban areas in the vicinity of deep excavations, areas at a macro-regional scale subject to anthropogenic influences caused by mining, etc.). These problems are very crucial, especially for safety assessment of important hydrotechnical constructions, as well as for modeling and estimating mining damage. Based on the geodetic monitoring data, a substantial basic empirical material was created, comprising many years of research results concerning displacements of controlled points situated on the crown and foreland of an exemplary earth dam, and used to assess the behaviour and safety of the object during its whole operating period. A research method at a macro-regional scale was applied to investigate some phenomena connected with the operation of the analysed big hydrotechnical construction. Applying a semivariogram function enabled the spatial variability analysis of displacements. Isotropic empirical semivariograms were calculated and then, theoretical parameters of analytical functions were determined, which approximated the courses of the mentioned empirical variability measure. Using ordinary (block) kriging at the grid nodes of an elementary spatial grid covering the analysed object, the values of the Z* estimated means of displacements were calculated together with the accompanying assessment of uncertainty estimation - a standard deviation of estimation σk. Raster maps of the distribution of estimated averages Z* and raster maps of deviations of estimation σk (in perspective

  18. Geodetic Control Points, Chippewa County has been working on tightening up their control network over the years. The first network was constructed in 1993, with densification done from 2008-2011., Published in 2011, Not Applicable scale, Chippewa County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Geodetic Control Points dataset current as of 2011. Chippewa County has been working on tightening up their control network over the years. The first network was...

  19. On the assimilation of absolute geodetic dynamic topography in a global ocean model: impact on the deep ocean state

    Science.gov (United States)

    Androsov, Alexey; Nerger, Lars; Schnur, Reiner; Schröter, Jens; Albertella, Alberta; Rummel, Reiner; Savcenko, Roman; Bosch, Wolfgang; Skachko, Sergey; Danilov, Sergey

    2018-05-01

    General ocean circulation models are not perfect. Forced with observed atmospheric fluxes they gradually drift away from measured distributions of temperature and salinity. We suggest data assimilation of absolute dynamical ocean topography (DOT) observed from space geodetic missions as an option to reduce these differences. Sea surface information of DOT is transferred into the deep ocean by defining the analysed ocean state as a weighted average of an ensemble of fully consistent model solutions using an error-subspace ensemble Kalman filter technique. Success of the technique is demonstrated by assimilation into a global configuration of the ocean circulation model FESOM over 1 year. The dynamic ocean topography data are obtained from a combination of multi-satellite altimetry and geoid measurements. The assimilation result is assessed using independent temperature and salinity analysis derived from profiling buoys of the AGRO float data set. The largest impact of the assimilation occurs at the first few analysis steps where both the model ocean topography and the steric height (i.e. temperature and salinity) are improved. The continued data assimilation over 1 year further improves the model state gradually. Deep ocean fields quickly adjust in a sustained manner: A model forecast initialized from the model state estimated by the data assimilation after only 1 month shows that improvements induced by the data assimilation remain in the model state for a long time. Even after 11 months, the modelled ocean topography and temperature fields show smaller errors than the model forecast without any data assimilation.

  20. Rapid Ice-Sheet Changes and Mechanical Coupling to Solid-Earth/Sea-Level and Space Geodetic Observation

    Science.gov (United States)

    Adhikari, S.; Ivins, E. R.; Larour, E. Y.

    2015-12-01

    Perturbations in gravitational and rotational potentials caused by climate driven mass redistribution on the earth's surface, such as ice sheet melting and terrestrial water storage, affect the spatiotemporal variability in global and regional sea level. Here we present a numerically accurate, computationally efficient, high-resolution model for sea level. Unlike contemporary models that are based on spherical-harmonic formulation, the model can operate efficiently in a flexible embedded finite-element mesh system, thus capturing the physics operating at km-scale yet capable of simulating geophysical quantities that are inherently of global scale with minimal computational cost. One obvious application is to compute evolution of sea level fingerprints and associated geodetic and astronomical observables (e.g., geoid height, gravity anomaly, solid-earth deformation, polar motion, and geocentric motion) as a companion to a numerical 3-D thermo-mechanical ice sheet simulation, thus capturing global signatures of climate driven mass redistribution. We evaluate some important time-varying signatures of GRACE inferred ice sheet mass balance and continental hydrological budget; for example, we identify dominant sources of ongoing sea-level change at the selected tide gauge stations, and explain the relative contribution of different sources to the observed polar drift. We also report our progress on ice-sheet/solid-earth/sea-level model coupling efforts toward realistic simulation of Pine Island Glacier over the past several hundred years.

  1. The influence of previous low back trouble, general health, and working conditions on future sick-listing because of low back trouble. A 15-year follow-up study of risk indicators for self-reported sick-listing caused by low back trouble.

    Science.gov (United States)

    Müller, C F; Monrad, T; Biering-Sørensen, F; Darre, E; Deis, A; Kryger, P

    1999-08-01

    A 15-year follow-up study. To find risk indicators for self-reported sick-listing because of low back trouble and to evaluate which variables were the most important indicators of work incapacity resulting from low back trouble during the follow-up period of 15 years. The initial data were obtained from a health survey conducted in a general population from the Municipality of Glostrup, Denmark. The follow-up data included information from the Central Person Register, the Early Retirement Pension Register, and a postal questionnaire regarding self-reported sick-listing because of low back trouble. An epidemiologic study, in which logistic regression analyses were used for evaluation of the data. The model used consisted of the variable in question, age, gender, and previous experience of low back trouble, along with interactions. It was found that 22 of 37 variables were risk indicators for later self-reported sick-listing because of low back trouble during the preceding year or the 7 years before the date of follow-up evaluation. In analyzing the most significant variables simultaneously, it was found that information from the initial investigation about sick-listing in general during the previous 10 years, sciatic pain, use of analgesics for low back trouble, previous sick-listing because of low back trouble, and occupation were the most important risk indicators for self-reported work incapacity resulting from low back trouble during the follow-up period of 15 years. Findings showed that the strongest prognostic indicators of later sick-listing because of low back trouble involve information from the person about previous sick-listing behavior in general and previous experience of low back trouble episodes, especially if these had been accompanied by sciatic pain, use of analgesics, or previous low back trouble sick-listing.

  2. Shallow Faulting in Morelia, Mexico, Based on Seismic Tomography and Geodetically Detected Land Subsidence

    Science.gov (United States)

    Cabral-Cano, E.; Arciniega-Ceballos, A.; Vergara-Huerta, F.; Chaussard, E.; Wdowinski, S.; DeMets, C.; Salazar-Tlaczani, L.

    2013-12-01

    Subsidence has been a common occurrence in several cities in central Mexico for the past three decades. This process causes substantial damage to the urban infrastructure and housing in several cities and it is a major factor to be considered when planning urban development, land-use zoning and hazard mitigation strategies. Since the early 1980's the city of Morelia in Central Mexico has experienced subsidence associated with groundwater extraction in excess of natural recharge from rainfall. Previous works have focused on the detection and temporal evolution of the subsidence spatial distribution. The most recent InSAR analysis confirms the permanence of previously detected rapidly subsiding areas such as the Rio Grande Meander area and also defines 2 subsidence patches previously undetected in the newly developed suburban sectors west of Morelia at the Fraccionamiento Del Bosque along, south of Hwy. 15 and another patch located north of Morelia along Gabino Castañeda del Rio Ave. Because subsidence-induced, shallow faulting develops at high horizontal strain localization, newly developed a subsidence areas are particularly prone to faulting and fissuring. Shallow faulting increases groundwater vulnerability because it disrupts discharge hydraulic infrastructure and creates a direct path for transport of surface pollutants into the underlying aquifer. Other sectors in Morelia that have been experiencing subsidence for longer time have already developed well defined faults such as La Colina, Central Camionera, Torremolinos and La Paloma faults. Local construction codes in the vicinity of these faults define a very narrow swath along which housing construction is not allowed. In order to better characterize these fault systems and provide better criteria for future municipal construction codes we have surveyed the La Colina and Torremolinos fault systems in the western sector of Morelia using seismic tomographic techniques. Our results indicate that La Colina Fault

  3. HEART TRANSPLANTATION IN PATIENTS WITH PREVIOUS OPEN HEART SURGERY

    Directory of Open Access Journals (Sweden)

    R. Sh. Saitgareev

    2016-01-01

    Full Text Available Heart Transplantation (HTx to date remains the most effective and radical method of treatment of patients with end-stage heart failure. The defi cit of donor hearts is forcing to resort increasingly to the use of different longterm mechanical circulatory support systems, including as a «bridge» to the follow-up HTx. According to the ISHLT Registry the number of recipients underwent cardiopulmonary bypass surgery increased from 40% in the period from 2004 to 2008 to 49.6% for the period from 2009 to 2015. HTx performed in repeated patients, on the one hand, involves considerable technical diffi culties and high risks; on the other hand, there is often no alternative medical intervention to HTx, and if not dictated by absolute contradictions the denial of the surgery is equivalent to 100% mortality. This review summarizes the results of a number of published studies aimed at understanding the immediate and late results of HTx in patients, previously underwent open heart surgery. The effect of resternotomy during HTx and that of the specifi c features associated with its implementation in recipients previously operated on open heart, and its effects on the immediate and long-term survival were considered in this review. Results of studies analyzing the risk factors for perioperative complications in repeated recipients were also demonstrated. Separately, HTx risks after implantation of prolonged mechanical circulatory support systems were examined. The literature does not allow to clearly defi ning the impact factor of earlier performed open heart surgery on the course of perioperative period and on the prognosis of survival in recipients who underwent HTx. On the other hand, subject to the regular fl ow of HTx and the perioperative period the risks in this clinical situation are justifi ed as a long-term prognosis of recipients previously conducted open heart surgery and are comparable to those of patients who underwent primary HTx. Studies

  4. Geodetic exploration of strain along the El Pilar Fault in northeastern Venezuela

    Science.gov (United States)

    Reinoza, C.; Jouanne, F.; Audemard, F. A.; Schmitz, M.; Beck, C.

    2015-03-01

    We use Global Navigation Satellite Systems observations in northeastern Venezuela to constrain the El Pilar Fault (EPF) kinematics and to explore the effects of the variable elastic properties of the surrounding medium and of the fault geometry on inferred slip rates and locking depth. The velocity field exhibits an asymmetric velocity gradient on either side of the EPF. We use five different approaches to explore possible models to explain this asymmetry. First, we infer a 1.6 km locking depth using a classic elastic half-space dislocation model. Second, we infer a 1.5 km locking depth and a 0.33 asymmetry coefficient using a heterogeneous asymmetric model, including contrasting material properties on either side of a vertical fault, suggesting that the igneous-metamorphic terranes on the northern side are ~2 times more rigid than the sedimentary southern side. Third, we use a three-dimensional elastostatic model to evaluate the presence of a compliant zone, suggesting a 30% reduction of rigidity in the upper 3 km at the depth of a 1 to 5 km wide fault zone. Fourth, we evaluate the distribution of fault slip, revealing a widespread partial creep pattern in the eastern upper segment, while the upper western segment exhibits a partially locked area, which coincides with the rupture surface of the 1797 and 1929 earthquakes. To supplement these models, we upgrade the previously published displacement simulation method using nonvertical dislocations with data acquired between 2003 and 2013. The localized aseismic displacement pattern associated with creeping or partially creeping fault segments could explain the low level of historic seismicity.

  5. Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004

    Directory of Open Access Journals (Sweden)

    N Dabiri

    2008-04-01

    Full Text Available ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent of the subjects and 19 people (47.5 percent of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.

  6. Impact of previously disadvantaged land-users on sustainable ...

    African Journals Online (AJOL)

    Impact of previously disadvantaged land-users on sustainable agricultural ... about previously disadvantaged land users involved in communal farming systems ... of input, capital, marketing, information and land use planning, with effect on ...

  7. 22 CFR 40.91 - Certain aliens previously removed.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a result...

  8. A new approach to the unrest and subsequent eruption at El Hierro Island (2011) based on petrological, seismological, geodetical and gravimetric data

    Science.gov (United States)

    Meletlidis, Stavros; Di Roberto, Alessio; Domínguez Cerdeña, Itahiza; Pompilio, Massimo; García-Cañada, Laura; Bertagnini, Antonella; Benito Saz, Maria Angeles; Del Carlo, Paola; Sainz-Maza Aparicio, Sergio; Lopez Moreno, Carmen; Moure García, David

    2014-05-01

    A shallow submarine eruption took place on 10th October 2011, about 1.8 km off the coast of La Restinga, a small village located in El Hierro (Canary Islands, Spain). The eruption lasted for about four months and ended by early March 2012. The eruption was preceded by an unrest episode that initiated about three months before, in July 2011, and characterized by more than 10,000 localized earthquakes accompanied by up to 5 cm of vertical ground deformation. In the Canary Islands, this event represents the first case of an eruption that was monitored since the unrest to the end by the monitoring network of IGN (Instituto Geográfico National), providing a huge dataset that includes geophysical (seismic, magnetic and gravimetric), geodetic, geochemistry and petrological data. In this work we use the seismic, GPS and gravity records collected by IGN along with the petrological data derived from the study of various lava balloons, scoriaceous fragments and ash.Geophysical and geochemical monitoring tools provide a variety of information that need to be interpreted in terms of magma movement and/or interaction of magma with host rocks. We present a model, based on this data, which describes the intrusion and ascent of the magma. According to this model, a major intrusion beneath and around preexisting high-density magmatic bodies, localized in the central sector of the island, led to an eruption in the Southern sector of the island. After a failed attempt to reach the surface, while various dykes were emplaced, through a low fractured area in the Central and Northern parts of the island, the ascending magma finally found its way in the submarine area of La Restinga, in the South rift zone, at a depth of 350 m below sea level. Feeding of the eruption was achieved by the ascension of an important volume of material from the upper mantle which was emplaced near the crust-mantle boundary. However, the very energetic post-eruptive unrests - we had five episodes up today with

  9. Influence of Previous Knowledge in Torrance Tests of Creative Thinking

    Directory of Open Access Journals (Sweden)

    María Aranguren

    2015-07-01

    Full Text Available The aim of this work is to analyze the influence of study field, expertise and recreational activities participation in Torrance Tests of Creative Thinking (TTCT, 1974 performance. Several hypotheses were postulated to explore the possible effects of previous knowledge in TTCT verbal and TTCT figural university students’ outcomes. Participants in this study included 418 students from five study fields: Psychology;Philosophy and Literature, Music; Engineering; and Journalism and Advertising (Communication Sciences. Results found in this research seem to indicate that there in none influence of the study field, expertise and recreational activities participation in neither of the TTCT tests. Instead, the findings seem to suggest some kind of interaction between certain skills needed to succeed in specific studies fields and performance on creativity tests, such as the TTCT. These results imply that TTCT is a useful and valid instrument to measure creativity and that some cognitive process involved in innovative thinking can be promoted using different intervention programs in schools and universities regardless the students study field.

  10. Determining root correspondence between previously and newly detected objects

    Science.gov (United States)

    Paglieroni, David W.; Beer, N Reginald

    2014-06-17

    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  11. The long-term consequences of previous hyperthyroidism

    DEFF Research Database (Denmark)

    Hjelm Brandt Kristensen, Frans

    2015-01-01

    Thyroid hormones affect every cell in the human body, and the cardiovascular changes associated with increased levels of thyroid hormones are especially well described. As an example, short-term hyperthyroidism has positive chronotropic and inotropic effects on the heart, leading to a hyperdynamic...... with CVD, LD and DM both before and after the diagnosis of hyperthyroidism. Although the design used does not allow a stringent distinction between cause and effect, the findings indicate a possible direct association between hyperthyroidism and these morbidities, or vice versa....... vascular state. While it is biologically plausible that these changes may induce long-term consequences, the insight into morbidity as well as mortality in patients with previous hyperthyroidism is limited. The reasons for this are a combination of inadequately powered studies, varying definitions...

  12. Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

    Science.gov (United States)

    Denholm, Rachel; Schüz, Joachim; Straif, Kurt; Stücker, Isabelle; Jöckel, Karl-Heinz; Brenner, Darren R.; De Matteis, Sara; Boffetta, Paolo; Guida, Florence; Brüske, Irene; Wichmann, Heinz-Erich; Landi, Maria Teresa; Caporaso, Neil; Siemiatycki, Jack; Ahrens, Wolfgang; Pohlabeln, Hermann; Zaridze, David; Field, John K.; McLaughlin, John; Demers, Paul; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Dumitru, Rodica Stanescu; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Kendzia, Benjamin; Peters, Susan; Behrens, Thomas; Vermeulen, Roel; Brüning, Thomas; Kromhout, Hans

    2014-01-01

    Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case–control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20–1.48 and OR, 1.50; 95% CI, 1.21–1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33–4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis “only.” Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case–control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. PMID:25054566

  13. Twelve previously unknown phage genera are ubiquitous in global oceans.

    Science.gov (United States)

    Holmfeldt, Karin; Solonenko, Natalie; Shah, Manesh; Corrier, Kristen; Riemann, Lasse; Verberkmoes, Nathan C; Sullivan, Matthew B

    2013-07-30

    Viruses are fundamental to ecosystems ranging from oceans to humans, yet our ability to study them is bottlenecked by the lack of ecologically relevant isolates, resulting in "unknowns" dominating culture-independent surveys. Here we present genomes from 31 phages infecting multiple strains of the aquatic bacterium Cellulophaga baltica (Bacteroidetes) to provide data for an underrepresented and environmentally abundant bacterial lineage. Comparative genomics delineated 12 phage groups that (i) each represent a new genus, and (ii) represent one novel and four well-known viral families. This diversity contrasts the few well-studied marine phage systems, but parallels the diversity of phages infecting human-associated bacteria. Although all 12 Cellulophaga phages represent new genera, the podoviruses and icosahedral, nontailed ssDNA phages were exceptional, with genomes up to twice as large as those previously observed for each phage type. Structural novelty was also substantial, requiring experimental phage proteomics to identify 83% of the structural proteins. The presence of uncommon nucleotide metabolism genes in four genera likely underscores the importance of scavenging nutrient-rich molecules as previously seen for phages in marine environments. Metagenomic recruitment analyses suggest that these particular Cellulophaga phages are rare and may represent a first glimpse into the phage side of the rare biosphere. However, these analyses also revealed that these phage genera are widespread, occurring in 94% of 137 investigated metagenomes. Together, this diverse and novel collection of phages identifies a small but ubiquitous fraction of unknown marine viral diversity and provides numerous environmentally relevant phage-host systems for experimental hypothesis testing.

  14. [ANTITHROMBOTIC MEDICATION IN PREGNANT WOMEN WITH PREVIOUS INTRAUTERINE GROWTH RESTRICTION].

    Science.gov (United States)

    Neykova, K; Dimitrova, V; Dimitrov, R; Vakrilova, L

    2016-01-01

    To analyze pregnancy outcome in patients who were on antithrombotic medication (AM) because of previous pregnancy with fetal intrauterine growth restriction (IUGR). The studied group (SG) included 21 pregnancies in 15 women with history of previous IUGR. The patients were on low dose aspirin (LDA) and/or low molecular weight heparin (LMWH). Pregnancy outcome was compared to the one in two more groups: 1) primary group (PG) including the previous 15 pregnancies with IUGR of the same women; 2) control group (CG) including 45 pregnancies of women matched for parity with the ones in the SG, with no history of IUGR and without medication. The SG, PG and CG were compared for the following: mean gestational age (g.a.) at birth, mean birth weight (BW), proportion of cases with early preeclampsia (PE), IUGR (total, moderate, and severe), intrauterine fetal death (IUFD), neonatal death (NND), admission to NICU, cesarean section (CS) because of chronic or acute fetal distress (FD) related to IUGR, PE or placental abruption. Student's t-test was applied to assess differences between the groups. P values < 0.05 were considered statistically significant. The differences between the SG and the PG regarding mean g. a. at delivery (33.7 and 29.8 w.g. respectively) and the proportion of babies admitted to NICU (66.7% vs. 71.4%) were not statistically significant. The mean BW in the SG (2114,7 g.) was significantly higher than in the PG (1090.8 g.). In the SG compared with the PG there were significantly less cases of IUFD (14.3% and 53.3% respectively), early PE (9.5% vs. 46.7%) moderate and severe IUGR (10.5% and 36.8% vs. 41.7% and 58.3%). Neonatal mortality in the SG (5.6%) was significantly lower than in the PG (57.1%), The proportion of CS for FD was not significantly different--53.3% in the SG and 57.1% in the PG. On the other hand, comparison between the SG and the CG demonstrated significantly lower g.a. at delivery in the SG (33.7 vs. 38 w.g.) an lower BW (2114 vs. 3094 g

  15. Implementing a C++ Version of the Joint Seismic-Geodetic Algorithm for Finite-Fault Detection and Slip Inversion for Earthquake Early Warning

    Science.gov (United States)

    Smith, D. E.; Felizardo, C.; Minson, S. E.; Boese, M.; Langbein, J. O.; Guillemot, C.; Murray, J. R.

    2015-12-01

    The earthquake early warning (EEW) systems in California and elsewhere can greatly benefit from algorithms that generate estimates of finite-fault parameters. These estimates could significantly improve real-time shaking calculations and yield important information for immediate disaster response. Minson et al. (2015) determined that combining FinDer's seismic-based algorithm (Böse et al., 2012) with BEFORES' geodetic-based algorithm (Minson et al., 2014) yields a more robust and informative joint solution than using either algorithm alone. FinDer examines the distribution of peak ground accelerations from seismic stations and determines the best finite-fault extent and strike from template matching. BEFORES employs a Bayesian framework to search for the best slip inversion over all possible fault geometries in terms of strike and dip. Using FinDer and BEFORES together generates estimates of finite-fault extent, strike, dip, preferred slip, and magnitude. To yield the quickest, most flexible, and open-source version of the joint algorithm, we translated BEFORES and FinDer from Matlab into C++. We are now developing a C++ Application Protocol Interface for these two algorithms to be connected to the seismic and geodetic data flowing from the EEW system. The interface that is being developed will also enable communication between the two algorithms to generate the joint solution of finite-fault parameters. Once this interface is developed and implemented, the next step will be to run test seismic and geodetic data through the system via the Earthworm module, Tank Player. This will allow us to examine algorithm performance on simulated data and past real events.

  16. An improved evaluation of the seismic/geodetic deformation-rate ratio for the Zagros Fold-and-Thrust collisional belt

    Science.gov (United States)

    Palano, Mimmo; Imprescia, Paola; Agnon, Amotz; Gresta, Stefano

    2018-04-01

    We present an improved picture of the ongoing crustal deformation field for the Zagros Fold-and-Thrust Belt continental collision zone by using an extensive combination of both novel and published GPS observations. The main results define the significant amount of oblique Arabia-Eurasia convergence currently being absorbed within the Zagros: right-lateral shear along the NW trending Main Recent fault in NW Zagros and accommodated between fold-and-thrust structures and NS right-lateral strike-slip faults on Southern Zagros. In addition, taking into account the 1909-2016 instrumental seismic catalogue, we provide a statistical evaluation of the seismic/geodetic deformation-rate ratio for the area. On Northern Zagros and on the Turkish-Iranian Plateau, a moderate to large fraction (˜49 and >60 per cent, respectively) of the crustal deformation occurs seismically. On the Sanandaj-Sirjan zone, the seismic/geodetic deformation-rate ratio suggests that a small to moderate fraction (<40 per cent) of crustal deformation occurs seismically; locally, the occurrence of large historic earthquakes (M ≥ 6) coupled with the high geodetic deformation, could indicate overdue M ≥ 6 earthquakes. On Southern Zagros, aseismic strain dominates crustal deformation (the ratio ranges in the 15-33 per cent interval). Such aseismic deformation is probably related to the presence of the weak evaporitic Hormuz Formation which allows the occurrence of large aseismic motion on both subhorizontal faults and surfaces of décollement. These results, framed into the seismotectonic framework of the investigated region, confirm that the fold-and-thrust-dominated deformation is driven by buoyancy forces; by contrast, the shear-dominated deformation is primary driven by plate stresses.

  17. On the inversion of geodetic integrals defined over the sphere using 1-D FFT

    Science.gov (United States)

    García, R. V.; Alejo, C. A.

    2005-08-01

    An iterative method is presented which performs inversion of integrals defined over the sphere. The method is based on one-dimensional fast Fourier transform (1-D FFT) inversion and is implemented with the projected Landweber technique, which is used to solve constrained least-squares problems reducing the associated 1-D cyclic-convolution error. The results obtained are as precise as the direct matrix inversion approach, but with better computational efficiency. A case study uses the inversion of Hotine’s integral to obtain gravity disturbances from geoid undulations. Numerical convergence is also analyzed and comparisons with respect to the direct matrix inversion method using conjugate gradient (CG) iteration are presented. Like the CG method, the number of iterations needed to get the optimum (i.e., small) error decreases as the measurement noise increases. Nevertheless, for discrete data given over a whole parallel band, the method can be applied directly without implementing the projected Landweber method, since no cyclic convolution error exists.

  18. Dynamics of Kilauea's Magmatic System Imaged Using a Joint Analysis of Geodetic and Seismic Data

    Science.gov (United States)

    Wauthier, C.; Roman, D. C.; Poland, M. P.; Fukushima, Y.; Hooper, A. J.

    2012-12-01

    Nowadays, Interferometric Synthetic Aperture Radar (InSAR) is commonly used to study a wide range of active volcanic areas. InSAR provides high-spatial-resolution measurements of surface deformation with centimeter-scale accuracy. At Kilauea Volcano, Hawai'i, InSAR shows complex processes that are not well constrained by GPS data (which have relatively poor spatial resolution). However, GPS data have higher temporal resolution than InSAR data. Both datasets are thus complementary. To overcome some of the limitations of conventional InSAR, which are mainly induced by temporal decorrelation, topographic, orbital and atmospheric delays, a Multi-Temporal InSAR (MT-InSAR) approach can be used. MT-InSAR techniques involve the processing of multiple SAR acquisitions over the same area. Two classes of MT-InSAR algorithms are defined: the persistent scatterers (PS) and small baseline (SBAS) methods. Each method is designed for a specific type of scattering mechanism. A PS pixel is a pixel in which a single scatterer dominates, while the contributions from other scatterers are negligible. A SBAS pixel is a pixel that includes distributed scatterers, which have a phase with little decorrelation over short time periods. Here, we apply the "StaMPS" ("Stanford Method for Permanent Scatterers") technique, which incorporates both a PS and SBAS approach, on ENVISAT and ALOS datasets acquired from 2003 to 2010 at Kilauea. In particular, we focus our InSAR analysis on the time period before the June 2007 "Father's Day" dike intrusion and eruption, and also incorporate seismic and GPS data in our models. Our goal is to identify any precursors to the Father's Day event within Kilauea's summit magma system, east rift zone, and/or southwest rift zone.

  19. Geodetic monitoring (TLS of a steel transport trestle bridge located in an active mining exploitation site

    Directory of Open Access Journals (Sweden)

    Skoczylas Arkadiusz

    2016-09-01

    Full Text Available Underground mining exploitation causes, in general, irregular vertical and horizontal shifts in the superficial layer of the rock mass. In the case of construction objects seated on this layer, a deformation of the object’s foundation can be observed. This leads to additional loads and deformations. Identification of surface geometry changes in construction objects located within the premises of underground mining exploitation areas is an important task as far as safety of mining sites is concerned. Surveys targeting shifts and deformations in engineering objects preformed with the use of classic methods are of a selective nature and do not provide the full image of the phenomenon being the subject of the observation. This paper presents possibilities of terrestrial laser scanning technology application in the monitoring of engineering objects that allows for a complete spatial documentation of an object subjected to the influence of an active mining exploitation. This paper describes an observation of a 100 m section of a steel transport trestle bridge located on the premises of hard coal mine Lubelski Węgiel “Bogdanka” S.A. carried out in 2015. Measurements were carried out using a Z+F Imager 5010C scanner at an interval of 3.5 months. Changes in the structure’s geometry were determined by comparing the point clouds recorded during the two measurement periods. The results of the analyses showed shifts in the trestle bridge towards the exploited coal wall accompanied by object deformation. The obtained results indicate the possibility of of terrestrial laser scanning application in studying the aftereffects of underground mining exploitation on surface engineering objects.

  20. GEOdetic Data assimilation and EStimation of references for climate change InvEstigation. An overall presentation of the French GEODESIE project

    Science.gov (United States)

    Nahmani, S.; Coulot, D.; Biancale, R.; Bizouard, C.; Bonnefond, P.; Bouquillon, S.; Collilieux, X.; Deleflie, F.; Garayt, B.; Lambert, S. B.; Laurent-Varin, S.; Marty, J. C.; Mercier, F.; Metivier, L.; Meyssignac, B.; Pollet, A.; Rebischung, P.; Reinquin, F.; Richard, J. Y.; Tertre, F.; Woppelmann, G.

    2017-12-01

    Many major indicators of climate change are monitored with space observations. This monitoring is highly dependent on references that only geodesy can provide. The current accuracy of these references does not permit to fully support the challenges that the constantly evolving Earth system gives rise to, and can consequently limit the accuracy of these indicators. Thus, in the framework of the GGOS, stringent requirements are fixed to the International Terrestrial Reference Frame (ITRF) for the next decade: an accuracy at the level of 1 mm and a stability at the level of 0.1 mm/yr. This means an improvement of the current quality of ITRF by a factor of 5-10. Improving the quality of the geodetic references is an issue which requires a thorough reassessment of the methodologies involved. The most relevant and promising method to improve this quality is the direct combination of the space-geodetic measurements used to compute the official references of the IERS. The GEODESIE project aims at (i) determining highly-accurate global and consistent references and (ii) providing the geophysical and climate research communities with these references, for a better estimation of geocentric sea level rise, ice mass balance and on-going climate changes. Time series of sea levels computed from altimetric data and tide gauge records with these references will also be provided. The geodetic references will be essential bases for Earth's observation and monitoring to support the challenges of the century. The geocentric time series of sea levels will permit to better apprehend (i) the drivers of the global mean sea level rise and of regional variations of sea level and (ii) the contribution of the global climate change induced by anthropogenic greenhouse gases emissions to these drivers. All the results and computation and quality assessment reports will be available at geodesie_anr.ign.fr.This project, supported by the French Agence Nationale de la Recherche (ANR) for the period

  1. New geodetic measurements in central Afar constraining the Arabia-Somalia-Nubia triple junction kinematics

    Science.gov (United States)

    Doubre, C.; Deprez, A.; Masson, F.; Socquet, A.; Lewi, E.; Grandin, R.; Calais, E.; Wright, T. J.; Bendick, R. O.; Pagli, C.; Peltzer, G.; de Chabalier, J. B.; Ibrahim Ahmed, S.

    2014-12-01

    The Afar Depression is an extraordinary submerged laboratory where the crustal mechanisms involved in the active rifting process can be studied. But the crustal movements at the regional scale are complicated by being the locus of the meeting of three divergent plate boundaries: the oceanic spreading ridges of the Red Sea and the Aden Ridge and the intra-continental East-African Rift (EAR). We present here the first GPS measurements conducted in a new network in Central Afar, complementing existing networks in Eritrea, around the Manda-Harraro 2005-2010 active segment, in the Northern part of the EAR and in Djibouti. Even if InSAR data were appropriate for mapping the deformation field, the results are difficult to interpret for analyzing the regional kinematics because of the atmospheric conditions, the lack of complete data catalogue, the acquisition configuration and the small velocity variations. Therefore, our measurements in the new sites are crucial to obtain an accurate velocity field over the whole depression, and focus specifically on the spatial organization of the deformation to characterize the tripe junction. These first results show that a small part of the motion of the Somalia plate with respect to the Nubia plate or the Arabia plate (2-3 mm/yr) occurs south of the Tadjura Gulf and East of the Adda-do segment in Southern Afar. The complex kinematic pattern involves a clockwise rotation of this Southeastern part of the Afar rift and can be related to the significant seismic activity regularly recorded in the region of Jigjiga (northern Somalia-Ethiopia border). The western continuation of the Aden Ridge into Afar extends West of the Asal rift segment and does not reach the young active segment of Manda-Inakir (MI). A slow gradient of velocity is observed across the Dobi Graben and across the large systems of faults between Lake Abhe and the MI rift segment. A striking change of the velocity direction occurs in the region of Assaïta, west of Lake

  2. Strain rates estimated by geodetic observations in the Borborema Province, Brazil

    Science.gov (United States)

    Marotta, Giuliano Sant'Anna; França, George Sand; Monico, João Francisco Galera; Bezerra, Francisco Hilário R.; Fuck, Reinhardt Adolfo

    2015-03-01

    The strain rates for the Borborema Province, located in northeastern Brazil, were estimated in this study. For this purpose, we used GNSS tracking stations with a minimum of two years data. The data were processed using the software GIPSY, version 6.2, provided by the JPL of the California Institute of Technology. The PPP method was used to process the data using the non-fiducial approach. Satellite orbits and clock were supplied by the JPL. Absolute phase center offsets and variations for both the receiver and the satellite antennaes were applied, together with ambiguity resolution; corrections of the first and second order effects of the ionosphere and troposphere models adopting the VMF1 mapping function; 10° elevation mask; FES2004 oceanic load model and terrestrial tide WahrK1 PolTid FreqDepLove OctTid. From a multi annual solution, involving at least 2 years of continuous data, the coordinates and velocities as well as their accuracies were estimated. The strain rates were calculated using the Delaunay triangulation and the Finite Element Method. The results show that the velocity direction is predominantly west and north, with maximum variation of 4.0 ± 1.5 mm/year and 4.1 ± 0.5 mm/year for the x and y components, respectively. The highest strain values of extension and contraction were 0.109552 × 10-6 ± 3.65 × 10-10/year and -0.072838 × 10-6 ± 2.32 × 10-10/year, respectively. In general, the results show that the highest strain and variation of velocity values are located close to the Potiguar Basin, region that concentrates seismic activities of magnitudes of up to 5.2 mb. We conclude that the contraction direction of strain is consistent with the maximum horizontal stress derived from focal mechanism and breakout data. In addition, we conclude that the largest strain rates occur around the Potiguar Basin, an area already recognized as one of the major sites of seismicity in intraplate South America.

  3. Urethrotomy has a much lower success rate than previously reported.

    Science.gov (United States)

    Santucci, Richard; Eisenberg, Lauren

    2010-05-01

    We evaluated the success rate of direct vision internal urethrotomy as a treatment for simple male urethral strictures. A retrospective chart review was performed on 136 patients who underwent urethrotomy from January 1994 through March 2009. The Kaplan-Meier method was used to analyze stricture-free probability after the first, second, third, fourth and fifth urethrotomy. Patients with complex strictures (36) were excluded from the study for reasons including previous urethroplasty, neophallus or previous radiation, and 24 patients were lost to followup. Data were available for 76 patients. The stricture-free rate after the first urethrotomy was 8% with a median time to recurrence of 7 months. For the second urethrotomy stricture-free rate was 6% with a median time to recurrence of 9 months. For the third urethrotomy stricture-free rate was 9% with a median time to recurrence of 3 months. For procedures 4 and 5 stricture-free rate was 0% with a median time to recurrence of 20 and 8 months, respectively. Urethrotomy is a popular treatment for male urethral strictures. However, the performance characteristics are poor. Success rates were no higher than 9% in this series for first or subsequent urethrotomy during the observation period. Most of the patients in this series will be expected to experience failure with longer followup and the expected long-term success rate from any (1 through 5) urethrotomy approach is 0%. Urethrotomy should be considered a temporizing measure until definitive curative reconstruction can be planned. 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  4. A Geodetic Strain Rate Model for the Pacific-North American Plate Boundary, western United States

    Science.gov (United States)

    Kreemer, C.; Hammond, W. C.; Blewitt, G.; Holland, A. A.; Bennett, R. A.

    2012-04-01

    We present a model of crustal strain rates derived from GPS measurements of horizontal station velocities in the Pacific-North American plate boundary in the western United States. The model reflects a best estimate of present-day deformation from the San Andreas fault system in the west to the Basin and Range province in the east. Of the total 2,846 GPS velocities used in the model, 1,197 are derived by ourselves, and 1,649 are taken from (mostly) published results. The velocities derived by ourselves (the "UNR solution") are estimated from GPS position time-series of continuous and semi-continuous stations for which data are publicly available. We estimated ITRF2005 positions from 2002-2011.5 using JPL's GIPSY-OASIS II software with ambiguity resolution applied using our custom Ambizap software. Only stations with time-series that span at least 2.25 years are considered. We removed from the time-series continental-scale common-mode errors using a spatially-varying filtering technique. Velocity uncertainties (typically 0.1-0.3 mm/yr) assume that the time-series contain flicker plus white noise. We used a subset of stations on the stable parts of the Pacific and North American plates to estimate the Pacific-North American pole of rotation. This pole is applied as a boundary condition to the model and the North American - ITRF2005 pole is used to rotate our velocities into a North America fixed reference frame. We do not include parts of the time-series that show curvature due to post-seismic deformation after major earthquakes and we also exclude stations whose time-series display a significant unexplained non-linearity or that are near volcanic centers. Transient effects longer than the observation period (i.e., slow viscoelastic relaxation) are left in the data. We added to the UNR solution velocities from 12 other studies. The velocities are transformed onto the UNR solution's reference frame by estimating and applying a translation and rotation that minimizes

  5. A System to Produce Precise Global GPS Network Solutions for all Geodetic GPS Stations in the World

    Science.gov (United States)

    Blewitt, G.; Kreemer, C. W.

    2010-12-01

    We have developed an end-to-end system that automatically seeks and routinely retrieves geodetic GPS data from ~5000 stations (currently) around the globe, reduces the data into unique, daily global network solutions, and produces high precision time series for station coordinates ready for time-series analysis, geophysical modeling and interpretation. Moreover, “carrier range” data are produced for all stations, enabling epoch-by-epoch tracking of individual station motions by precise point positioning for investigation of sub-daily processes, such as post-seismic after-slip and ocean tidal loading. Solutions are computed in a global reference frame aligned to ITRF, and optionally in user-specified continental-scale reference frames that can filter out common-mode signals to enhance regional strain anomalies. We describe the elements of this system, the underlying signal processing theory, the products, operational statistics, and scientific applications of our system. The system is fundamentally based on precise point positioning using JPL's GIPSY OASIS II software, coupled with ambiguity resolution and a global network adjustment of ~300,000 parameters per day using our newly developed Ambizap3 software. The system is designed to easily and efficiently absorb stations that deliver data very late, by recycling prior computations in the network adjustment, such that the resulting network solution is identical to starting from scratch. Thus, it becomes possible to trawl continuously the Internet for late arriving data, or for newly discovered data, and seamlessly update all GPS station time series using the new information content. As new stations are added to the processing archive, automated e-mail requests are made to H.-G. Scherneck's server at Chalmers University to compute ocean loading coefficients used by the station motion model. Rinex file headers are parsed and compared with alias tables in order to infer the correct receiver type and antenna

  6. Use of Geodetic Laser Scanning to Evaluate the Curvature of Bedrock Surfaces in an Investigation of Sheeting Joint Formation

    Science.gov (United States)

    Martel, S. J.; Mitchell, K.

    2007-12-01

    We are using aerial and tripod-mounted geodetic laser scanning (GLS) data, together with photography and large-scale geologic mapping, to investigate the formation of sheeting joints in Yosemite National Park. Sheeting joints are opening-mode fractures that form subparallel to the topography, and over broad areas in Yosemite they define the bedrock surface. Rock slabs bounded by sheeting joints superficially resemble the layers of an onion. Our hypothesis is that sheeting joints form where a tensile stress normal to the topographic surface exists in the shallow subsurface. This condition is met where k2 P22 + k3 P33 > γ cosβ, where k2 and k3 are the principal curvatures of the bedrock surface, P22 and P33 are the corresponding normal stresses parallel to the principal stresses, γ is the unit weight of the rock, and β is the slope angle. Sheeting joints are predicted where at least one of the principal curvatures is sufficiently convex (negative) and the corresponding normal stress is sufficiently compressive (negative). We use aerial GLS data with a vertical resolution of ~10 cm and a point spacing of ~1 m to measure the slope and curvature of the bedrock surface at the scale of a ridge or valley. We use tripod-mounted GLS data with a point spacing of ~5 cm, large-scale geologic mapping, and photographs to detect steps between consecutive sheeting joints, with the step height giving the sheet joint spacing. Outcrops hosting sheeting joints have a stair-step appearance with a distinctive curvature signature: high convex curvature at the top of a step, and high concave curvature at the step bottom. Steps between sheeting joints with a spacing of less than a meter or so are difficult to detect using the aerial GLS data. Apparently the interpolation of aerial data onto a grid, necessary for our curvature codes, and the smoothing of gridded data to filter out trees compromises the value of the aerial GLS data in detecting the step edges, even though the vertical

  7. 49 CFR 173.23 - Previously authorized packaging.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Previously authorized packaging. 173.23 Section... REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Preparation of Hazardous Materials for Transportation § 173.23 Previously authorized packaging. (a) When the regulations specify a packaging with a specification marking...

  8. 28 CFR 10.5 - Incorporation of papers previously filed.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Incorporation of papers previously filed... CARRYING ON ACTIVITIES WITHIN THE UNITED STATES Registration Statement § 10.5 Incorporation of papers previously filed. Papers and documents already filed with the Attorney General pursuant to the said act and...

  9. 75 FR 76056 - FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT:

    Science.gov (United States)

    2010-12-07

    ... SECURITIES AND EXCHANGE COMMISSION Sunshine Act Meeting FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT: STATUS: Closed meeting. PLACE: 100 F Street, NE., Washington, DC. DATE AND TIME OF PREVIOUSLY ANNOUNCED MEETING: Thursday, December 9, 2010 at 2 p.m. CHANGE IN THE MEETING: Time change. The closed...

  10. Plane and geodetic surveying

    CERN Document Server

    Johnson, Aylmer

    2014-01-01

    IntroductionAim And ScopeClassification Of SurveysThe Structure Of This BookGeneral Principles Of SurveyingErrorsRedundancyStiffnessAdjustmentPlanning And Record KeepingPrincipal Surveying ActivitiesEstablishing Control NetworksMappingSetting OutResectioningDeformation MonitoringAngle MeasurementThe Surveyor's CompassThe ClinometerThe Total StationMaking ObservationsChecks On Permanent AdjustmentsDistance MeasurementGeneralTape MeasurementsOptical Methods (Tachymetry)Electromagnetic Distance Measurement (EDM)Ultrasonic MethodsGNSSLevellingTheoryThe InstrumentTechniqueBookingPermanent Adjustmen

  11. Repeat immigration: A previously unobserved source of heterogeneity?

    Science.gov (United States)

    Aradhya, Siddartha; Scott, Kirk; Smith, Christopher D

    2017-07-01

    Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to understand the outcomes of immigrants. This study constructs detailed migration histories to test whether misclassified migrations may mask important heterogeneities. In doing so, we identify a previously understudied group of migrants called repeat immigrants, and show that they differ systematically from permanent immigrants. In addition, we quantify the degree to which migration information is misreported in the registers. The analysis is carried out in two steps. First, we estimate income trajectories for repeat immigrants and permanent immigrants to understand the degree to which they differ. Second, we test data validity by cross-referencing migration information with changes in income to determine whether there are inconsistencies indicating misreporting. From the first part of the analysis, the results indicate that repeat immigrants systematically differ from permanent immigrants in terms of income trajectories. Furthermore, income trajectories differ based on the way in which years since migration is calculated. The second part of the analysis suggests that misreported migration events, while present, are negligible. Repeat immigrants differ in terms of income trajectories, and may differ in terms of other outcomes as well. Furthermore, this study underlines that Swedish registers provide a reliable data source to analyze groups which are unidentifiable in other data sources.

  12. Mediastinal involvement in lymphangiomatosis: a previously unreported MRI sign

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Vikas; Shah, Sachit; Barnacle, Alex; McHugh, Kieran [Great Ormond Street Hospital for Children, Department of Radiology, London (United Kingdom); Sebire, Neil J. [Great Ormond Street Hospital for Children, Department of Histopathology, London (United Kingdom); Brock, Penelope [Great Ormond Street Hospital for Children, Department of Oncology, London (United Kingdom); Harper, John I. [Great Ormond Street Hospital for Children, Department of Dermatology, London (United Kingdom)

    2011-08-15

    Multifocal lymphangiomatosis is a rare systemic disorder affecting children. Due to its rarity and wide spectrum of clinical, histological and imaging features, establishing the diagnosis of multifocal lymphangiomatosis can be challenging. The purpose of this study was to describe a new imaging sign in this disorder: paraspinal soft tissue and signal abnormality at MRI. We retrospectively reviewed the imaging, clinical and histopathological findings in a cohort of eight children with thoracic involvement from this condition. Evidence of paraspinal chest disease was identified at MRI and CT in all eight of these children. The changes comprise heterogeneous intermediate-to-high signal parallel to the thoracic vertebrae on T2-weighted sequences at MRI, with abnormal paraspinal soft tissue at CT and plain radiography. Multifocal lymphangiomatosis is a rare disorder with a broad range of clinicopathological and imaging features. MRI allows complete evaluation of disease extent without the use of ionising radiation and has allowed us to describe a previously unreported imaging sign in this disorder, namely, heterogeneous hyperintense signal in abnormal paraspinal tissue on T2-weighted images. (orig.)

  13. Pertussis-associated persistent cough in previously vaccinated children.

    Science.gov (United States)

    Principi, Nicola; Litt, David; Terranova, Leonardo; Picca, Marina; Malvaso, Concetta; Vitale, Cettina; Fry, Norman K; Esposito, Susanna

    2017-11-01

    To evaluate the role of Bordetella pertussis infection, 96 otherwise healthy 7- to 17-year-old subjects who were suffering from a cough lasting from 2 to 8 weeks were prospectively recruited. At enrolment, a nasopharyngeal swab and an oral fluid sample were obtained to search for pertussis infection by the detection of B. pertussis DNA and/or an elevated titre of anti-pertussis toxin IgG. Evidence of pertussis infection was found in 18 (18.7 %; 95 % confidence interval, 11.5-28.0) cases. In 15 cases, the disease occurred despite booster administration. In two cases, pertussis was diagnosed less than 2 years after the booster injection, whereas in the other cases it was diagnosed between 2 and 9 years after the booster dose. This study used non-invasive testing to show that pertussis is one of the most important causes of long-lasting cough in school-age subjects. Moreover, the protection offered by acellular pertussis vaccines currently wanes more rapidly than previously thought.

  14. Payload specialist Reinhard Furrer show evidence of previous blood sampling

    Science.gov (United States)

    1985-01-01

    Payload specialist Reinhard Furrer shows evidence of previous blood sampling while Wubbo J. Ockels, Dutch payload specialist (only partially visible), extends his right arm after a sample has been taken. Both men show bruises on their arms.

  15. Choice of contraception after previous operative delivery at a family ...

    African Journals Online (AJOL)

    Choice of contraception after previous operative delivery at a family planning clinic in Northern Nigeria. Amina Mohammed‑Durosinlorun, Joel Adze, Stephen Bature, Caleb Mohammed, Matthew Taingson, Amina Abubakar, Austin Ojabo, Lydia Airede ...

  16. Estudios previos cursados y género de los maestros de primaria en formación: efectos sobre la resolución de problemas / Pre-service primary teachers' gender and studies previously undertaken: effects on problem solving

    Directory of Open Access Journals (Sweden)

    Alexandre Caballer Alonso

    2014-10-01

    Full Text Available Resumen: Este trabajo analiza la influencia del género y los estudios previos cursados en la resolución de problemas. Se utilizó un diseño experimental con dos variables independientes (género y estudios previos y una variable dependiente (puntuación en los problemas. Se administró un cuadernillo con dos problemas de diferente estructura a 66 estudiantes de tercer curso del Grado de Maestro en Educacion Primaria de la misma Facultad (Facultad de Magisterio de la Universidad de Valencia, España. Los resultados de los análisis de varianza simple muestran que: a los estudiantes de sexo masculino resuelven el problema difícil con más éxito que las estudiantes, b los estudiantes que han cursado bachillerato no resuelven los problemas significativamente mejor que los que no lo han cursado y, c los estudiantes que siguieron un itinerario en 4º de la ESO con Física y Química resuelven significativamente mejor los problemas que los restantes. Abstract: This study analyses the influence of gender and studies previously undertaken on problem-solving. An experimental design was used with two independent variables (gender and studies previously undertaken and one dependent variable (scores in the problems. A booklet containing two word problems that differ from each other in structure was administered to 66 third-year pre-service primary teachers from the same Faculty (Faculty of Teacher Training, University of Valencia, Spain. The results of the analyses of variance simple showed that: a men undergraduate students solve the difficult problem more successfully than women undergraduate students, b students who had completed post-compulsory secondary education do not solve the problems significantly better than the others, and c students who had studied physics and chemistry in the tenth grade at high school solve the problems significantly better than the others.

  17. Sacrococcygeal pilonidal disease: analysis of previously proposed risk factors

    Directory of Open Access Journals (Sweden)

    Ali Harlak

    2010-01-01

    Full Text Available PURPOSE: Sacrococcygeal pilonidal disease is a source of one of the most common surgical problems among young adults. While male gender, obesity, occupations requiring sitting, deep natal clefts, excessive body hair, poor body hygiene and excessive sweating are described as the main risk factors for this disease, most of these need to be verified with a clinical trial. The present study aimed to evaluate the value and effect of these factors on pilonidal disease. METHOD: Previously proposed main risk factors were evaluated in a prospective case control study that included 587 patients with pilonidal disease and 2,780 healthy control patients. RESULTS: Stiffness of body hair, number of baths and time spent seated per day were the three most predictive risk factors. Adjusted odds ratios were 9.23, 6.33 and 4.03, respectively (p<0.001. With an adjusted odds ratio of 1.3 (p<.001, body mass index was another risk factor. Family history was not statistically different between the groups and there was no specific occupation associated with the disease. CONCLUSIONS: Hairy people who sit down for more than six hours a day and those who take a bath two or less times per week are at a 219-fold increased risk for sacrococcygeal pilonidal disease than those without these risk factors. For people with a great deal of hair, there is a greater need for them to clean their intergluteal sulcus. People who engage in work that requires sitting in a seat for long periods of time should choose more comfortable seats and should also try to stand whenever possible.

  18. Overview of new GNSS tropospheric products for GNSS-meteorology and their assessment at Geodetic Observatory Pecny (CZ)

    Science.gov (United States)

    Dousa, J.; Vaclavovic, P.; Gyori, G.

    2012-12-01

    Geodetic Observatory Pecný (GOP) has a long-term experience in the estimation of precise tropospheric parameters from GNSS permanent stations, in particular under the limited timelines of near real time. More than a decade, the GOP zenith total delays (ZTD) contributed to various projects in Europe (COST-716, TOUGH, E-GVAP, E-GVAP II) and the operational ZTD hourly updated product flows via the meteorological observation exchange network - GTS - to the end users worldwide. Currently, the GOP regional ZTD product is operationally assimilated in Météo France and UK MetOffice at least and further exploited in various ways at many other meteorological institutions. New developments at GOP over last three years consist of a) implementation and assessment of the global hourly ZTD product of about 170 stations, b) implementation of routine multi-GNSS (GPS+GLONASS) ZTD European product, and c) implementation of ultra-fast/real-time ZTD product. The GOP global ZTD product has been implemented on request of the meteorological institutions running global numerical weather forecasting models. The global ZTD product was seriously evaluated over ten months (Oct 2009 - Aug 2011) when compared to reprocessed EUREF and IGS ZTDs, radiosondes and ZTDs derived from UK MetOffice's global numerical weather model. After the evaluation (and on special request of UK MetOffice) the product has been switched from testing to operational status within the framework of the EUMETNET EIG GPS Water Vapour Programme (E-GVAP) and officially disseminated via the GTS network. The GOP multi-GNSS ZTD solution has been tested since 2009 shortly after developing GOP ultra-rapid GPS+GLONASS orbits for the International GNSS Service (IGS). A specific bias of mean value 1.5 mm was identified between GPS- and GLONASS-only ZTD at that time, and relation to the IGS05 antenna phase centre offset and variation models (PCO+PCV) identified. Consequently, the implementation of a routine operation has been done

  19. Geodetic constraints on present-day motion of the Arabian Plate: Implications for Red Sea and Gulf of Aden rifting

    Science.gov (United States)

    Arrajehi, Abdullah; McClusky, Simon; Reilinger, Robert; Daoud, Mohamed; Alchalbi, Abdulmutaleb; Ergintav, Semih; Gomez, Francisco; Sholan, Jamal; Bou-Rabee, Firyal; Ogubazghi, Ghebrebrhan; Haileab, Biniam; Fisseha, Shimelles; Asfaw, Laike; Mahmoud, Salah; Rayan, Ali; Bendik, Rebecca; Kogan, Lewis

    2010-06-01

    Five years of continuously recording GPS observations in the Kingdom of Saudi Arabia together with new continuous and survey-mode GPS observations broadly distributed across the Arabian Peninsula provide the basis for substantially improved estimates of present-day motion and internal deformation of the Arabian plate. We derive the following relative, geodetic Euler vectors (latitude (°N), longitude (°E), rate (°/Myr, counterclockwise)) for Arabia-Nubia (31.7 ± 0.2, 24.6 ± 0.3, 0.37 ± 0.01), Arabia-Somalia (22.0 ± 0.5, 26.2 ± 0.5, 0.40 ± 0.01), Arabia-India (18.0 ± 3.8, 87.6 ± 3.3, 0.07 ± 0.01), Arabia-Sinai (35.7 ± 0.8, 17.1 ± 5.0, 0.15 ± 0.04), and Arabia-Eurasia (27.5 ± 0.1, 17.6 ± 0.3, 0.404 ± 0.004). We use these Euler vectors to estimate present-day stability of the Arabian plate, the rate and direction of extension across the Red Sea and Gulf of Aden, and slip rates along the southern Dead Sea fault south of the Lebanon restraining bend (4.5-4.7 ± 0.2 mm/yr, left lateral; 0.8-1.1 ± 0.3 mm/yr extension) and the Owens fracture zone (3.2-2.5 ± 0.5 mm/yr, right lateral, increasing from north to south; 1-2 mm/yr extension). On a broad scale, the Arabian plate has no resolvable internal deformation (weighted root mean square of residual motions for Arabia equals 0.6 mm/yr), although there is marginally significant evidence for N-S shortening in the Palmyride Mo