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Sample records for previous full ci

  1. Structural Biology of CI from Phage TP901-1

    DEFF Research Database (Denmark)

    Rasmussen, Kim Krighaar

    (CTD), separated by a linker of various lengths. The NTD is responsible for DNA binding and the CTD is responsible for oligomerization of the CI protein. A Helix-turn-Helix motif is usually responsible for DNA binding. This thesis presents a structural characterization of the CI repressor from TP901...... condition of the CTD, responsible for the arrangement of the hexameric CI repressor. The arrangement of the CI repressor for TP901-1 has previously been described to have 32 point group symmetry based on SAXS studies. The CTD crystallizes with P3121 or P3221 symmetry with one molecule in the asymmetric unit......-length CI can only be answered unambiguously by solving the CTD crystal structure or by use of alternative techniques on the full-length CI....

  2. TravisTorrent : Synthesizing Travis CI and GitHub for Full-Stack Research on Continuous Integration

    NARCIS (Netherlands)

    Beller, M.M.; Gousios, Giorgos; Zaidman, A.E.

    2017-01-01

    Continuous Integration (CI) has become a best practice of modern software development. Thanks in part to its tight integration with GitHub, Travis CI has emerged as arguably the most widely used CI platform for Open-Source Software (OSS) development. However, despite its prominent role in Software

  3. Filosofia da ciência e ensino da ciência: uma analogia

    Directory of Open Access Journals (Sweden)

    Alberto Villani

    2001-01-01

    Full Text Available Neste trabalho, inicialmente explicitaremos nossa compreensão do debate entre Kuhn, Popper, Lakatos e Feyerabend na Conferencia Internacional sobre Filosofia da Ciência (1965, delineando as diferenças nas posições de nossos filósofos. Em seguida apresentaremos um quadro das posições sobre o ensino de ciências, assim como nos parecem caracterizar os último 30 anos de pesquisas na área. Finalmente tentaremos uma aproximação dos dois campos, procurando salientar as implicações que a problemática filosófica teve e tem para uma maior compreensão do ensino de ciências e matemática.

  4.  Dylematy harmonizacji rachunkowości

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    Jerzy Gierusz

    2015-06-01

    Full Text Available Harmonizacja rachunkowości finansowej jest procesem przynoszącym wiele korzyści, ale także generującym poważne zagrożenia. Wśród pozytywnych stron harmonizacji wymienić należy: wzmocnienie funkcji alokacyjnej rynków kapitałowych, wzrost zaufania inwestorów do sprawozdań finansowych, rozszerzenie możliwości pozyskiwania kapitału pożyczkowego, obniżenie kosztów funkcjonowania korporacji międzynarodowych. Towarzyszące harmonizacji zjawiska niepożądane to: wyeliminowanie porównywalności sprawozdań finansowych na poziomie krajowym, przekreślenie znacznej części dorobku szkoły kontynentalnej rachunkowości, ustanowienie monopolu w tworzeniu standardów, zanik normatywnego nurtu badań w rachunkowości.

  5. Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone

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    G.J. Paz-Filho

    2007-12-01

    Full Text Available Recombinant human thyroid-stimulating hormone (rhTSH enhances 131I uptake, permitting a decrease in radiation for the treatment of multinodular goiter (MNG. Our objective was to evaluate the safety and efficacy of a single 0.1-mg dose of rhTSH, followed by 30 mCi 131I, in patients with MNG. Seventeen patients (15 females, 59.0 ± 13.1 years, who had never been submitted to 131I therapy, received a single 0.1-mg injection of rhTSH followed by 30 mCi 131I on the next day. Mean basal thyroid volume measured by computed tomography was 106.1 ± 64.4 mL. 131I 24-h uptake, TSH, free-T4, T3, thyroglobulin, anti-thyroid antibodies, and thyroid volume were evaluated at regular intervals of 12 months. Mean 131I 24-h uptake increased from 18.1 ± 9.7 to 49.6 ± 13.4% (P < 0.001, a median 2.6-fold increase (1.2 to 9.2. Peak hormonal levels were 10.86 ± 5.44 mU/L for TSH (a median 15.5-fold increase, 1.80 ± 0.48 ng/dL for free-T4, 204.61 ± 58.37 ng/dL for T3, and a median of 557.0 ng/mL for thyroglobulin. The adverse effects observed were hyperthyroidism (17.6%, painful thyroiditis (29.4% and hypothyroidism (52.9%. Thyroid volume was reduced by 34.3 ± 14.3% after 6 months (P < 0.001 and by 46.0 ± 14.6% after 1 year (P < 0.001. Treatment of MNG with a single 0.1-mg dose of rhTSH, followed by a fixed amount of radioactivity of 131I, leads to an efficacious decrease in thyroid volume for the majority of the patients, with a moderate incidence of non-serious and readily treatable adverse effects.

  6. As ciências naturais e as ciências do espírito na era da globalização

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    Jaeschke, Walter

    2006-01-01

    Full Text Available Este artigo, o autor apresenta, primeiramente, reflexões de cunho histórico sobre a relação entre as Ciências Naturais e as Ciências do Espírito, seguidas de observações, de caráter mais sistemático, sobre o conceito das próprias Ciências do Espírito. Com fundamento nessas observações, tece algumas reflexões sobre até que ponto podemos esperar da globalização efeitos sobre as Ciências Naturais e as Ciências do Espírito

  7. A Biblioteconomia e a Ciência da Informação na taxionomia das ciências de Charles Sanders Peirce

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    Carlos Cândido de Almeida

    2005-07-01

    Full Text Available Mostra a taxionomia das ciências desenvolvida por Charles Sanders Peirce (1839-1914 que divide as ciências em três ramos: ciências teóricas, ciências da revisão e ciências aplicadas. Detalha principalmente as ciências teóricas: a Matemática, a Filosofia e a Idioscopia. Discute também o conceito de Biblioteconomia e de Ciência da Informação e que segundo as definições e características, encontradas na literatura consultada, estão na condição de ciências aplicadas, direcionadas a problemas práticos da sociedade, ou seja, o problema de controle e disseminação da informação.

  8. "ESSAY ON CI" BY LI QINGZHAO

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    Anna Dashchenko

    2016-10-01

    Full Text Available The article presents the first Russian translation of "Essay on Ci" with detailed comments. It was written by the outstanding Chinese poetess Li Qingzhao and considered to be the first theoretical treatise dedicated to genre ci. The article revealed that the poetess used three strategies to make a genre demarcation: to legitimise, dichotomise and historicise. To legitimise means to justify that ci is a genre of poetry by identifying the same traits with official poetry shi (e.g. using the classical quotations and allusions. To dichotomise is to determine a core element of genre and oppose it to the other element identifying the similar genre (e.g. music separates ci from shi. To historicise is to develop or discover the unique historical past (e.g. the source of ci is in antiquity. The article also examined the strategy to invent classics: Li Qingzhao wrote the apophatic history of genre ci pointing not to the merits but weaknesses of her predecessors.

  9. CI Implementation

    DEFF Research Database (Denmark)

    Jørgensen, Frances; Boer, Harry; Laugen, Bjørge Timenes

    2006-01-01

    There are a number of tools available for organizations wishing to measure and subsequently develop Continuous Improvement (CI). In this article, we review and evaluate a well-accepted CI development model, namely the CI Maturity Model (Bessant and Caffyn, 1997), against data collected from the 2nd...... Continuous Improvement Network Survey and a number of empirical cases described in the literature. While the CI Maturity Model suggests that CI maturation ought to be a linear process, the findings in this article suggest that there are feasible alternatives for companies to develop CI capability....

  10. Ciência no globo-ciência

    OpenAIRE

    Mendonça,Otávio Machado Lopes de

    1996-01-01

    O objetivo da presente pesquisa foi verificar as áreas de conhecimento científico que se fizeram presentes na programação do Globo-Ciência, veiculada pela Rede Globo de Televisão,verificando também as estratégias usadas e o material empregado como recursos didáticos. O material utilizado foi o catálogo da programação do Globo-Ciência-10 anos (1984-1994). Os resultados mostram que as Ciências Exatas e da Terra foi a mais apresentada no programa com 49,65%,havendo pouco espaço para as outras, v...

  11. The Ciona intestinalis immune-related galectin genes (CiLgals-a and CiLgals-b) are expressed by the gastric epithelium.

    Science.gov (United States)

    Parrinello, Daniela; Sanfratello, Maria Antonietta; Vizzini, Aiti; Testasecca, Lelia; Parrinello, Nicolò; Cammarata, Matteo

    2017-03-01

    The transcription of two Ciona intestinalis galectin genes (CiLgals-a and CiLgals-b) is uparegulated by LPS in the pharynxis (hemocytes, vessel epithelium, endostilar zones) which is retained the main organ of the immunity. In this ascidian, for the first time we show, by immunohistochemistry and in situ hybridization methods, that these two immune-related genes are expressed in the gastric epithelium of naïve ascidians, whereas the galectins appear to be only contained in the intestine columnar epithelium. In addition, according to previous results on the pharynx, the genes are also expressed and galectins produced by hemocytes scattered in the connective tissue surrounding the gut. The genes expression and galectin localization in several tissues, including the previous findings on the transcription upregulation, the constitutive expression of these genes by endostylar zones and by the gastric epithelium suggest a potential multifunctional role of these galectins. In this respect, it is of interest to define where the CiLgals are normally found as related to the tissue functions. Such an approach should be a starting point for further investigations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Multicentre evaluation of the Naída CI Q70 sound processor: feedback from cochlear implant users and professionals

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    Jeanette Martin

    2016-12-01

    Full Text Available The aim of this survey was to gather data from both implant recipients and professionals on the ease of use of the Naída CI Q70 (Naída CI sound processor from Advanced Bionics and on the usefulness of the new functions and features available. A secondary objective was to investigate fitting practices with the new processor. A comprehensive user satisfaction survey was conducted in a total of 186 subjects from 24 centres. In parallel, 23 professional questionnaires were collected from 11 centres. Overall, there was high satisfaction with the Naída CI processor from adults, children, experienced and new CI users as well as from professionals. The Naída CI processor was shown as being easy to use by all ages of recipients and by professionals. The majority of experienced CI users rated the Naída CI processor as being similar or better than their previous processor in all areas surveyed. The Naída CI was recommended by the professionals for fitting in all populations. Features like UltraZoom, ZoomControl and DuoPhone would not be fitted to very young children in contrast to adults. Positive ratings were obtained for ease of use, comfort and usefulness of the new functions and features of the Naída CI sound processor. Seventy-seven percent of the experienced CI users rated the new processor as being better than their previous sound processor from a general point of view. The survey also showed that fitting practices were influenced by the age of the user.

  13. Zależność bodźcowości ciśnienia od cyrkulacji atmosferycznej w Warszawie

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    Katarzyna Rozbicka

    2016-09-01

    Full Text Available W pracy zbadano: czasowy rozkład ciśnienia atmosferycznego, bodźcowe oddziaływanie ciśnienia atmosferycznego o wartościach wyższych od 1015 hPa lub niższych od 985 hPa. Wyznaczono częstość i prawdopodobieństwo wystąpienia ciśnienia o oddziaływaniu bodźcowym oraz zanalizowano zależność zmian międzydobowych ciśnienia od typów cyrkulacji atmosferycznej według klasyfikacji Lityńskiego. Do obliczeń wykorzystano cogodzinne wartości ciśnienia atmosferycznego pochodzące ze stacji Ursynów SGGW z okresu 2011–2015. Na podstawie badań stwierdzono, że ciśnienie atmosferyczne o oddziaływaniu bodźcowym w Warszawie może wystąpić w każdym miesiącu z prawdopodobieństwem od 0,2% do 19,1%, w przypadku ciśnienia o wartościach wyższych niż 1015 hPa oraz od 0,1 do 3,4%, w przypadku ciśnienia niższego od 985 hPa, z wyjątkiem czerwca i sierpnia. Zmiany międzydobowe ciśnienia atmosferycznego mogą osiągać około 24 hPa, a częstość występowania bodźców „silnych” wywołanych tymi zmianami wyniosła w poszczególnych miesiącach od 1% do 16%, natomiast bodźców „bardzo silnych” od 2% do 8%. Spośród sytuacji synoptycznych największe znaczenie dla bodźcowości zmian ciśnienia mają sytuacje cyklonalne: szczególnie przy adwekcji powietrza z sektora północno-zachodniego (NWC.

  14. Reproductive outcomes in adolescents who had a previous birth or an induced abortion compared to adolescents' first pregnancies

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    Wenzlaff Paul

    2008-01-01

    Full Text Available Abstract Background Recently, attention has been focused on subsequent pregnancies among teenage mothers. Previous studies that compared the reproductive outcomes of teenage nulliparae and multiparae often did not consider the adolescents' reproductive histories. Thus, the authors compared the risks for adverse reproductive outcomes of adolescent nulliparae to teenagers who either have had an induced abortion or a previous birth. Methods In this retrospective cohort study we used perinatal data prospectively collected by obstetricians and midwives from 1990–1999 (participation rate 87–98% of all hospitals in Lower Saxony, Germany. From the 9742 eligible births among adolescents, women with multiple births, >1 previous pregnancies, or a previous spontaneous miscarriage were deleted and 8857 women Results In bivariate logistic regression analyses, compared to nulliparous teenagers, adolescents with a previous birth had higher risks for perinatal [OR = 2.08, CI = 1.11,3.89] and neonatal [OR = 4.31, CI = 1.77,10.52] mortality and adolescents with a previous abortion had higher risks for stillbirths [OR = 3.31, CI = 1.01,10.88] and preterm births [OR = 2.21, CI = 1.07,4.58]. After adjusting for maternal nationality, partner status, smoking, prenatal care and pre-pregnancy BMI, adolescents with a previous birth were at higher risk for perinatal [OR = 2.35, CI = 1.14,4.86] and neonatal mortality [OR = 4.70, CI = 1.60,13.81] and adolescents with a previous abortion had a higher risk for very low birthweight infants [OR = 2.74, CI = 1.06,7.09] than nulliparous teenagers. Conclusion The results suggest that teenagers who give birth twice as adolescents have worse outcomes in their second pregnancy compared to those teenagers who are giving birth for the first time. The prevention of the second pregnancy during adolescence is an important public health objective and should be addressed by health care providers who attend the first birth or the abortion

  15. Nudności i wymioty

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    Anna Mokrowiecka

    2010-12-01

    Full Text Available Nudności są nieprzyjemnym, niebolesnym odczuciem silnej, nieodpartej potrzeby zwymiotowania, z kolei wymioty polegają na gwałtownym wydaleniu treści żołądka przez usta w wyniku silnych skurczów mięśni brzucha i klatki piersiowej. Nudności i wymioty mogą występować niezależnie od siebie, ale najczęściej są ze sobą powiązane. Nudności i wymioty powstają w odpowiedzi zarówno na bodźce fizjologiczne, jak i patologiczne. Zwykle jednak przewlekłe nudności i wymioty są objawem chorób przewodu pokarmowego lub innych narządów. Choroby przewodu pokarmowego i otrzewnej stanowią szeroką grupę chorób wywołujących nudności i wymioty, począwszy od nieżytu żołądkowo-jelitowego o ostrym infekcyjnym tle, przez zatrucie pokarmowe i nadwrażliwość pokarmową, do stanów ostrych – niedrożności jelita cienkiego lub/i grubego. Leki i toksyny, między innymi cytostatyki, są jedną z najczęstszych przyczyn nudności i wymiotów. Wśród innych przyczyn nudności i wymiotów można wymienić: choroby OUN prowadzące do zwiększenia ciśnienia śródczaszkowego, choroby endokrynologiczne i metaboliczne (mocznica, kwasica ketonowa w cukrzycy, choroby tarczycy i przytarczyc oraz choroba Addisona, zawał ściany dolnej mięśnia sercowego, nudności i wymioty pooperacyjne. Nudności i wymioty jako choroby czynnościowe zostały ujęte w III kryteriach rzymskich w punkcie „Choroby czynnościowe żołądka i dwunastnicy”. W diagnostyce różnicowej należy uwzględnić czas trwania wymiotów, czas pomiędzy posiłkiem a wystąpieniem wymiotów, a także charakter treści wymiocin i inne objawy towarzyszące. Wywiad i badanie fizykalne dostarczają zwykle wystarczających informacji do postawienia prawidłowej diagnozy i ustalenia leczenia u większości chorych cierpiących na nudności i wymioty. Niektórzy pacjenci wymagają jednak badań laboratoryjnych, obrazowych i endoskopowych przed zastosowaniem odpowiedniej

  16. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  17. Nowe zasady działalności firm audytorskich

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    Kazimierz Sawicki

    2009-03-01

    Full Text Available W artykule przedstawiono zmiany, stanowiące implementację Dyrektywy 2006/43/WE Unii Europejskiej w części dotyczącej funkcjonowania firm audytorskich w Polsce. Zgłoszono uwagi popierające nowe rozwiązania, jak też zawierające wątpliwości dotyczące skuteczności ich stosowania w praktyce.

  18. ANALIZA NIEZAWODNOŚCI STACJI UZDATNIANIA WODY

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    Barbara TCHÓRZEWSKA-CIEŚLAK

    Full Text Available Systemy zbiorowego zaopatrzenia w wodę składają się z połączonych ze sobą elementów (podsystemów stanowiących integralna całość, współpracujących ze sobą w sposób ciągły w celu zapewnienia dla konsumentów wody o odpowiedniej jakości. W przypadku gdy jakość wody w źródle nie odpowiada normatywom stawianym wodzie przeznaczonej do spożycia przez ludzi, woda musi być poddana procesom uzdatniania. Niezawodność funkcjonowania stacji uzdatniania wody jest jednym z podstawowych elementów szeroko rozumianej analizy niezawodności i bezpieczeństwa całego systemu zbiorowego zaopatrzenia w wodę. Niezawodność dostawy wody polega na zapewnieniu stabilnych warunków, umożliwiających pokrycie bieżącego i perspektywicznego zapotrzebowania na wodę w odpowiedniej ilości i wymaganej jakości w dowolnym, dogodnym dla konsumentów wody czasie. W pracy przedstawiono podstawy analizy niezawodności, podano podstawowe miary oraz zasady wykorzystania struktur niezawodnościowych. Obliczenia wykonano dla stacji uzdatniania wody na podstawie schematu niezwodnościowego metodą jednoparametryczną. Na podstawie danych z eksploatacyjnych stacji uzdatniania wody (SUW wchodzącej w skład systemu zbiorowego zaopatrzenia w wodę miasta liczącego ok 80 tys. mieszkańców sporządzono schemat niewodności stacji oraz przeprowadzono obliczenia wskaźnika gotowości K. W metodzie wykorzystano podstawowe struktury niezawodnościowe. Wyznaczoną miarę niezawodności porównano z wartościami kryterialnymi.

  19. Dylematy standaryzacjisprawozdawczości finansowej,wyceny i pomiaru ryzyka

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    Dorota Dobija

    2010-09-01

    Full Text Available W artykule zostały poruszone zagadnienia związane z istotą przejrzystości fi-nansowej organizacji. Przejrzystość ta jest jednym z elementów efektywnego systemu ładu korporacyjnego, dlatego tempo zmian w tym obszarze jest narzucone przez refor-my w systemach ładu korporacyjnego. W pierwszej części opracowania jest dyskuto-wana rola menedżerów w zapewnieniu przejrzystości finansowej organizacji. Kolejna część opracowania obejmuje krytyczną dyskusję trzech istotnych wątków teore-tycznych wpływających na jakość sprawozdawczości: postępującej standaryzacji w rachunkowości, problemów wyceny w rachunkowości oraz zagadnień pomiaru i sprawozdawczości ryzyka w organizacji.

  20. Od ciężkości astmy do kontroli astmy. Metody oceny kontroli astmy

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    Joanna Mikołajczyk

    2009-09-01

    Full Text Available Według pierwszych wytycznych dotyczących postępowania w astmie leczenie astmy zależy od stopnia jej cięż- kości, określonej na podstawie objawów klinicznych i wskaźników czynności płuc. Ponieważ astma jest chorobą o zmiennym przebiegu, duże znaczenie ma jej ciągła ocena kliniczna i dostosowana do niej modyfikacja leczenia. Niestety, stopień ciężkości nie dopasowuje się elastycznie do odpowiedzi na leczenie. Biorąc ten fakt pod uwagę, światowi eksperci zalecają zmianę w postępowaniu z astmą, przedkładając uzyskanie klinicznej kontroli astmy nad ustaleniem stopnia jej ciężkości, wyróżniając astmę kontrolowaną, częściowo kontrolowaną i niekontrolowaną. Uzyskanie stanu pełnej kontroli astmy formułuje się w raporcie GINA 2006 jako główny cel leczenia. Kontrola astmy odnosi się do stopnia opanowania objawów i byłoby najlepiej, gdyby dotyczyła też markerów zapalenia i patofizjologicznych wykładników choroby. Określenie stopnia kontroli choroby zgodnie z obecnymi założeniami stanowi podstawę wyboru i modyfikacji leczenia – właściwe ustalenie stopnia kontroli astmy wpływa na skuteczność leczenia. Obecnie dostępnych jest wiele metod oceny kontroli astmy, wtym ocena parametrów klinicznych (objawy w ciągu dnia, objawy nocne, stosowanie leków rozszerzających oskrzela, ocena czynności płuc (PEF i FEV1, określenie zaawansowania zapalenia w drogach oddechowych (nieswoista nadreaktywność oskrzeli, stężenie tlenku azotu w powietrzu wydechowym, liczba eozynofili w plwocinie indukowanej. Dostępne są także subiektywnie oceniające kontrolę astmy kwestionariusze badawcze oraz szybkie testy kontroli astmy (ACT, ACQ, ATAQ. Z drugiej strony wciąż nie wypracowano jednoznacznego stanowiska, który z parametrów lub jakie połączenia parametrów najbardziej wiarygodnie określają kontrolę astmy. Ze względu na wieloczynnikową patogenezę astmy wydaje się, iż uzyskanie pe

  1. Filosofia da ciência, ensino de ciências e psicanálise: Explorando analogias

    Directory of Open Access Journals (Sweden)

    Alberto Villani

    2005-06-01

    Full Text Available Desenvolveremos um esquema referente às atitudes dos cientistas frente ao conhecimento científico, tendo como referência, de um lado, o debate entre Kuhn, Pepper, Lakatos e Feyerabend e, de outro, conceitos da psicanálise lacaniana. Em seguida, exploraremos esse esquema com uma analogia que nos permitirá elaborar novas interpretações para a educação em Ciências.

  2. Spectral reflectance properties of carbonaceous chondrites: 1. CI chondrites

    Science.gov (United States)

    Cloutis, E. A.; Hiroi, T.; Gaffey, M. J.; Alexander, C. M. O.'D.; Mann, P.

    2011-03-01

    Existing reflectance spectra of CI chondrites (18 spectra of 3 CIs) have been augmented with new (18 spectra of 2 CIs) reflectance spectra to ascertain the spectral variability of this meteorite class and provide insights into their spectral properties as a function of grain size, composition, particle packing, and viewing geometry. Particle packing and viewing geometry effects have not previously been examined for CI chondrites. The current analysis is focused on the 0.3-2.5 μm interval, as this region is available for the largest number of CI spectra. Reflectance spectra of powdered CI1 chondrites are uniformly dark (IOM), as no other CI opaque phase appears able to produce concurrent darkening and bluing. Magnetite can also explain the presence of an absorption feature near 1 μm in some CI spectra. The most blue-sloped spectra are generally associated with the larger grain size samples. For incidence and emission angles <60°, increasing phase angle results in darker and redder spectra, particularly below ∼1 μm. At high incidence angles (60°), increasing emission angle results in brighter and redder spectra. More densely packed samples and underdense (fluffed) samples show lower overall reflectance than normally packed and flat-surface powdered samples. Some B-class asteroids exhibit selected spectral properties consistent with CI chondrites, although perfect spectral matches have not been found. Because many CI chondrite spectra exhibit absorption features that can be related to specific mineral phases, the search for CI parent bodies can fruitfully be conducted using such parameters.

  3. Full-thickness knee articular cartilage defects in national football league combine athletes undergoing magnetic resonance imaging: prevalence, location, and association with previous surgery.

    Science.gov (United States)

    Nepple, Jeffrey J; Wright, Rick W; Matava, Matthew J; Brophy, Robert H

    2012-06-01

    To better define the prevalence and location of full-thickness articular cartilage lesions in elite football players undergoing knee magnetic resonance imaging (MRI) at the National Football League (NFL) Invitational Combine and assess the association of these lesions with previous knee surgery. We performed a retrospective review of all participants in the NFL Combine undergoing a knee MRI scan from 2005 to 2009. Each MRI scan was reviewed for evidence of articular cartilage disease. History of previous knee surgery including anterior cruciate ligament reconstruction, meniscal procedures, and articular cartilage surgery was recorded for each athlete. Knees with a history of previous articular cartilage restoration surgery were excluded from the analysis. A total of 704 knee MRI scans were included in the analysis. Full-thickness articular cartilage lesions were associated with a history of any previous knee surgery (P football players at the NFL Combine undergoing MRI. The lateral compartment appears to be at greater risk for full-thickness cartilage loss. Previous knee surgery, particularly meniscectomy, is associated with these lesions. Level IV, therapeutic case series. Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  4. Ciência global?

    OpenAIRE

    Abreu, Armando Trigo de

    2000-01-01

    No fim do séc. XX, poucas actividades podem reclamar um passado de universalidade tão longo e tão paradigmático como a ciência. Se eliminarmos ocasionais e limitados acessos de nacionalismo ou ideologismo mais destemperado que levaram à procura da ciência proletária ou da filosofia portuguesa, a história da ciência é uma história comum. Portugal está excepcionalmente bem situado para compreender esta característica da ciência universal. Três exemplos, apenas, podem ilustrar esta condição:...

  5. Cognitivismo e ciência cognitiva

    Directory of Open Access Journals (Sweden)

    Marcos Barbosa de Oliveira

    1990-01-01

    Full Text Available O objetivo da comunicação é caracterizar uma escola de pensamento-o cognitivismo-e a disciplina a que ela deu origem. Depois de um breve apanhado das origens do cognitivismo descrevem-se os princípios ontológicos e metodológicos que o definem. Mostra-se a seguir a relação que há entre os computadores e a idéia funcionalista de considerar a mente como um sistema cujos elementos são caracterizados por suas funções, e não por sua constituição material. Discute-se finalmente a natureza e o nome da disciplina gerada pelo cognitivismo, sugerindo-se que se trata de uma proto-ciência, a qual deve ser denominada "Estudos Cognitivos" de preferência a "Ciência Cognitiva".

  6. Kierunki zmiansprawozdawczości finansowej

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    Zbigniew Luty

    2010-05-01

    Full Text Available W artykule wskazano na możliwe kierunki zmian w sprawozdawczości finansowej w najbliższych latach. Wymieńmy najważniejsze: 1 bazą jest informacja oparta na dokumentacji księgowej w ujęciu historycznym, 2 sprawozdania celowe (dedykowane, 3 informacja finansowa jako towar na specyficznym rynku sprawozdań, 4 prawo bilansowe tworzone z minimalnym wpływem lobbingu inwestorów.

  7. Ci PERMIT

    CERN Multimedia

    Relations with the Host States Service

    1999-01-01

    The Swiss Permanent Mission to the International Organisations at Geneva recalls that only the spouses and children of members of personnel resident in Switzerland and in possession of a legitimation card of types 'B', 'C', 'D' or 'E' issued by the Swiss Federal Department of Foreign Affairs are entitled to benefit from a Ci Permit.The 'demande d'attestation de permis Ci' (request for a Ci permit attestation) can be sent to the Mission only through Personnel Division (Administrative Services, Office 33/1-025).Additional information on access by family members of CERN officials to the Swiss labour market are available to you on the Web site of the Relations with the Host States Service (cf. document entitled 'Employment in Switzerland for spouses and children of CERN officials' dated March 1996).Relations with the Host States Servicehttp://www.cern.ch/relations/Tel. 72848

  8. O Jornal Nacional e a Ciência

    Directory of Open Access Journals (Sweden)

    Diego Andres Salcedo

    2009-10-01

    Full Text Available Entendendo a informação científica como aquela capaz de contribuir para o desenvolvimento de uma cultura científica, analisamos neste trabalho aspectos relacionados à presença da informação sobre ciência no Jornal Nacional (JN, da Rede Globo de Televisão. A partir da observação do noticiário veiculado de 1º de janeiro a 31 de março de 2007, foi possível identificar 88 matérias que traziam informações relacionadas à ciência. O corpus nos permitiu categorizar os tipos de inserção da ciência no JN, esboçar o interesse do JN pelos temas científicos e discutir seu papel na formação de uma cultura científica do povo brasileiro.

  9. BIOGRAMY POLSKICH MYŚLICIELI RACHUNKOWOŚCI

    Directory of Open Access Journals (Sweden)

    Renata Biadacz

    2009-09-01

    Full Text Available Fragmenty artykułu: Włodzimierz Brzezin (1926–2008, profesor zwyczajny, doktor habilitowany, urodził się 1 lipca 1926 r. w Wieluniu, zmarł 29 grudnia 2008 r. w Częstochowie. (... Bilans działalności i osiągnięć Profesora Brzezina jest bardzo bogaty i trudno go przedstawić w skrócie. Należy jednak zaznaczyć, że jedną z cech charakteryzujących całokształt Jego zainteresowań naukowych jest szeroki krąg tematyczny. Obejmuje zagadnienia teoretyczne i praktyczne rachunkowości, zarówno sensu stricte, jak i sensu largo, jak również problematykę teorii pomiaru, analizy finansowej, controllingu, polityki bilansowej, wykorzystania rachunku kosztów przez kadrę inżynierską. Zdzisław Kołaczyk (1927–2008 docent doktor, urodził się 15 czerwca 1927 r. w Częstochowie, zmarł 9 lipca 2008 r. w Poznaniu. (... Działalność naukowa doc. dr Z. Kołaczyka skupiała się głównie na rachunkowości finansowej. Początkowo Jego zainteresowania naukowe koncentrowały się na rachunku kosztów przedsiębiorstw przemysłowych i budowlanych. Z tego zakresu opublikował kilka interesujących artykułów naukowych, zamieszczonych w Ruchu Prawniczym, Ekonomicznym i Socjologicznym oraz w Zeszytach Naukowych WSE w Poznaniu. W kolejnych latach doc. dra Z. Kołaczyka interesował rozwój rachunkowości jako nauki i działalności praktycznej

  10. Da possibilidade de uma Teoria Pura da Ciência da Informação: reflexões iniciais entre a Ciência da Informação e a Ciência do Direito

    Directory of Open Access Journals (Sweden)

    Max Cirino de Mattos

    Full Text Available O artigo discute a fragilidade epistemológica da Ciência da Informação, a partir da adoção de um termo polissêmico, como objeto científico, e a similaridade dessa situação com o contexto da criação da Teoria Pura do Direito de Hans Kelsen. Após a apresentação de algumas definições sobre o objeto da Ciência da Informação, discutem-se alguns reflexos relacionados à identidade científica e à fundamentação teórica derivadas de um objeto polissêmico. Apresenta-se uma breve introdução à Teoria Pura do Direito e algumas reflexões sobre a possibilidade de uma Teoria Pura da Ciência da Informação.

  11. Konwergencja rachunkowości finansowej i rachunkowości zarządczej w Polsce w świetle badań ankietowych

    Directory of Open Access Journals (Sweden)

    Przemysław Kabalski

    2018-03-01

    Full Text Available Celem artykułu jest określenie stopnia konwergencji rachunkowości finansowej i rachunkowości zarządczej w przedsiębiorstwach w Polsce. Do zbadania stopnia konwergencji wykorzystano metodę sondażową z zastosowaniem kwestionariusza ankiety. Okazało się, że poziom konwergencji rachunko- wości w badanych przedsiębiorstwach jest umiarkowany. Badania konwergencji rachunkowości na świecie nie są liczne, a w Polsce ‒ zupełnie wyjątkowe. Z tego względu badanie prezentowane w artykule jest istotne zarówno dla nauki, jak i praktyki rachunkowości. The aim of the article is to determine the level of convergence of financial accounting and management accounting in companies operating in Poland. In order to determine the level of the convergence, the survey method was used. It was found that the level of convergence of accounting in the companies examined is moderate. The number of studies on the convergence of accounting is very limited in the world, and in Poland they are quite unique. For this reason, the research presented in this article is rele- vant for both the science and the practice of accounting.

  12. Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone

    Energy Technology Data Exchange (ETDEWEB)

    Paz-Filho, G.J.; Mesa-Junior, C.O.; Boguszewski, C.L.; Carvalho, G.A.; Graf, H. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Endocrinologia e Metabologia; Olandoski, M. [Pontificia Univ. Catolica do Parana, Curitiba, PR (Brazil). Nucleo de Bioestatistica; Woellner, L.C. [Centro de Medicina Nuclear, Curitiba, PR (Brazil); Goedert, C.A. [Centro de Tomografia Computadorizada, Curitiba, PR (Brazil)

    2007-12-15

    Recombinant human thyroid-stimulating hormone (rhTSH) enhances {sup 131}I uptake, permitting a decrease in radiation for the treatment of multinodular goiter (MNG). Our objective was to evaluate the safety and efficacy of a single 0.1-mg dose of rhTSH, followed by 30 mCi {sup 131}I, in patients with MNG. Seventeen patients (15 females, 59.0 {+-} 13.1 years), who had never been submitted to {sup 131}I therapy, received a single 0.1-mg injection of rhTSH followed by 30 mCi {sup 131}I on the next day. Mean basal thyroid volume measured by computed tomography was 106.1 {+-} 64.4 mL. {sup 131}I 24-h uptake, TSH, free-T4, T3, thyroglobulin, anti-thyroid antibodies, and thyroid volume were evaluated at regular intervals of 12 months. Mean {sup 131}I 24-h uptake increased from 18.1 {+-} 9.7 to 49.6 {+-} 13.4% (P < 0.001), a median 2.6-fold increase (1.2 to 9.2). Peak hormonal levels were 10.86 {+-} 5.44 mU/L for TSH (a median 15.5-fold increase), 1.80 {+-} 0.48 ng/dL for free-T4, 204.61 {+-} 58.37 ng/dL for T3, and a median of 557.0 ng/mL for thyroglobulin. The adverse effects observed were hyperthyroidism (17.6%), painful thyroiditis (29.4%) and hypothyroidism (52.9%). Thyroid volume was reduced by 34.3 {+-} 14.3% after 6 months (P < 0.001) and by 46.0 {+-} 14.6% after 1 year (P < 0.001). Treatment of MNG with a single 0.1-mg dose of rhTSH, followed by a fixed amount of radioactivity of {sup 131}I, leads to an efficacious decrease in thyroid volume for the majority of the patients, with a moderate incidence of non-serious and readily treatable adverse effects. (author)

  13. As tendências atuais dos paradigmas: ciência, tecnologia e sociedade e ensino de ciências indígena no VII ENPEC

    Directory of Open Access Journals (Sweden)

    Maria Delourdes Maciel

    2014-01-01

    Full Text Available O Encontro Nacional de Pesquisas em Educação em Ciências é um evento bianual organizada pelos pesquisadores do ensino de Ciências. O objetivo principal desse encontro é reunir os professores e pesquisadores da área, para socializarem os relatos de experiência e pesquisas no ensino de Ciências. Nesse presente trabalho, foi realizado um mapeamento dos artigos apresentados nas seções de comunicação oral do VII ENPEC, somando um total de 425 artigos selecionados, procurou-se identificar os relacionados com a abordagem Ciências, Tecnologia e Sociedade (CTS no ensino de Ciências sua estrutura de organização e o numero de pesquisadores dessa área do Ensino de Ciências. Para esse estudo foi realizado uma pesquisa qualitativa de caráter bibliográfico, e para a análise dos dados buscou-se subsídios teóricos em Fiorentini (2002 e Bardin (2006 porque assim seria possível comparar minuciosamente os diferentes resultados obtidos. Conclui-se que a linha de pesquisa com a temática CTS apresentou 28 trabalhos cerca de 7% de trabalhos apresentados, confirmando uma sinalização nessa área de pesquisa pelos pesquisadores do ensino de Ciências e a temática sobre ensino de ciências indígena representou cerca de 1% dos trabalhos apresentados.

  14.  Spis treści

    Directory of Open Access Journals (Sweden)

    Mieczysław Dobija

    2014-04-01

    Full Text Available  Od Zespołu Redakcyjnego ............................................................................... 5 Mieczysław Dobija – Rachunkowość w systemie pomiaru aktywności ekonomicznej państwa – Accounting as part of an economic activity measurement system ............... 7 Renata Dyląg, Ewelina Puchalska – Raportowanie zagadnień środowiskowych i społecznych – Reporting on social and environmental issues .............................................. 23 Jacek Gad – Sprawozdanie z wyniku całościowego jako źródło informacji na temat kapitałowych przychodów i kosztów – doświadczenia polskiego i niemieckiego rynku kapitałowego – Statement of comprehensive income as a source of information on capital income and expenses – experience of Polish and German capital markets...... 47 Piotr Luty – Ocena kondycji finansowej łączących się spółek na przykładzie jednostek z wybranych województw Polski Zachodniej – Assessment of financial position of merging companies based on selected provinces of Western Poland ............................................................................ 69 Irena Sobańska – Znaczenie dorobku naukowego Profesor Elżbiety Burzym dla rozwoju nauki i praktyki rachunkowości w Polsce – The importance of Professor Elżbieta Burzym’s contribution to the development of accounting theory, research and practice in Poland ........................ 83 Arleta Szadziewska – Rachunkowość jako źródło informacji na temat realizacji strategii społecznej odpowiedzialności biznesu – Accounting as a source of information for CSR strategy ............................. 95 Halina Waniak-Michalak – Informacja o pracy wolontariuszy w sprawozdaniach organizacji pożytku publicznego w Polsce – Information on volunteer labour in reports of public benefit organizations in Poland ............................................................................................................ 125

  15. Adverse obstetric outcomes in women with previous cesarean for dystocia in second stage of labor.

    Science.gov (United States)

    Jastrow, Nicole; Demers, Suzanne; Gauthier, Robert J; Chaillet, Nils; Brassard, Normand; Bujold, Emmanuel

    2013-03-01

    To evaluate obstetric outcomes in women undergoing a trial of labor (TOL) after a previous cesarean for dystocia in second stage of labor. A retrospective cohort study of women with one previous low transverse cesarean undergoing a first TOL was performed. Women with previous cesarean for dystocia in first stage and those with previous dystocia in second stage were compared with those with previous cesarean for nonrecurrent reasons (controls). Multivariable regressions analyses were performed. Of 1655 women, those with previous dystocia in second stage of labor (n = 204) had greater risks than controls (n = 880) to have an operative delivery [odds ratio (OR): 1.5; 95% confidence intervals (CI) 1.1 to 2.2], shoulder dystocia (OR: 2.9; 95% CI 1.1 to 8.0), and uterine rupture in the second stage of labor (OR: 4.9; 95% CI 1.1 to 23), and especially in case of fetal macrosomia (OR: 29.6; 95% CI 4.4 to 202). The median second stage of labor duration before uterine rupture was 2.5 hours (interquartile range: 1.5 to 3.2 hours) in these women. Previous cesarean for dystocia in the second stage of labor is associated with second-stage uterine rupture at next delivery, especially in cases of suspected fetal macrosomia and prolonged second stage of labor. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  16. Cinema, ciência e percepção.

    Directory of Open Access Journals (Sweden)

    Márcio Barreto

    Full Text Available Resumo O cinema invoca a questão dos limites da percepção humana, pois modula o tempo em imagens tão reais quanto artificiais, revelando algo mais próximo de uma nova dimensão da realidade do que de sua representação. No início do século XX, a ciência modifica o real percebido através das lentes dos microscópios e das teorias da física moderna; o parentesco entre cinema e ciência está principalmente naquilo que excede o campo perceptivo e é explorado neste artigo para mostrar como a tensão entre o caráter estático da fotografia e a fluidez fugitiva do tempo revela a ciência sem seus estereótipos habituais.

  17. Wykorzystanie informacji prospektywnychw sprawozdawczości finansowej zorientowanejna wartość na przykładzie MSR 36„Utrata wartości aktywów”

    Directory of Open Access Journals (Sweden)

    Irena Sobańska

    2009-12-01

    Full Text Available Autorzy artykułu wskazują na istotę i rosnące znaczenie informacji prospektywnych we współczesnych systemach sprawozdawczości finansowej opartej na MSSF. Ewolucja dokonująca się w sprawozdawczości finansowej, pod wpływem harmonizacji zasad rachunkowości wskutek ciągle zmieniających się MSSF, została przedstawiona na tle zmian dokonujących się w otoczeniu, w celach i w systemach zarządzania (orientacja strategiczna, wartość przedsiębiorstwa, jak również w systemach strategicznej rachunkowości zarządczej. Na podstawie szerokiego kontekstu analizy autorzy stawiają wniosek, że koncepcja wartości (przedsiębiorstwa stanowi istotny element systemu pomiaru i wyceny w systemie sprawozdawczości finansowej. Tworzy ona także spójną podstawę dla integracji rachunkowości zarządczej i rachunkowości finansowej w jeden system zapewniający użyteczne informacje zarówno dla użytkowników zewnętrznych, jak i wewnętrznych, których łączy wspólny cel – maksymalizacja wartości. Uwarunkowania tworzenia systemu sprawozdawczości opartego na informacjach prospektywnych, zorientowanego na wartość, jak również stopień dostosowania przedsiębiorstw do jego wdrożenia pokazano na przykładzie praktycznej realizacji postanowień MSR 36.

  18. Total hip arthroplasty after a previous pelvic osteotomy: A systematic review and meta-analysis.

    Science.gov (United States)

    Shigemura, T; Yamamoto, Y; Murata, Y; Sato, T; Tsuchiya, R; Wada, Y

    2018-06-01

    There are several reports regarding total hip arthroplasty (THA) after a previous pelvic osteotomy (PO). However, to our knowledge, until now there has been no formal systematic review and meta-analysis published to summarize the clinical results of THA after a previous PO. Therefore, we conducted a systematic review and meta-analysis of results of THA after a previous PO. We focus on these questions as follows: does a previous PO affect the results of subsequent THA, such as clinical outcomes, operative time, operative blood loss, and radiological parameters. Using PubMed, Web of Science, and Cochrane Library, we searched for relevant original papers. The pooling of data was performed using RevMan software (version 5.3, Cochrane Collaboration, Oxford, UK). A p-value50%, significant heterogeneity was assumed and a random-effects model was applied for the meta-analysis. A fixed-effects model was applied in the absence of significant heterogeneity. Eleven studies were included in this meta-analysis. The pooled results indicated that there was no significant difference in postoperative Merle D'Aubigne-Postel score (I 2 =0%, SMD=-0.15, 95% CI: -0.36 to 0.06, p=0.17), postoperative Harris hip score (I 2 =60%, SMD=-0.23, 95% CI: -0.50 to 0.05, p=0.10), operative time (I 2 =86%, SMD=0.37, 95% CI: -0.09 to 0.82, p=0.11), operative blood loss (I 2 =82%, SMD=0.23, 95% CI: -0.17 to 0.63, p=0.25), and cup abduction angle (I 2 =43%, SMD=-0.08, 95% CI: -0.25 to 0.09, p=0.38) between THA with and without a previous PO. However, cup anteversion angle of THA with a previous PO was significantly smaller than that of without a previous PO (I 2 =77%, SMD=-0.63, 95% CI: -1.13 to -0.13, p=0.01). Systematic review and meta-analysis of results of THA after a previous PO was performed. A previous PO did not affect the results of subsequent THA, except for cup anteversion. Because of the low quality evidence currently available, high-quality randomized controlled trials are required

  19. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    Directory of Open Access Journals (Sweden)

    Moreno Victor

    2011-08-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. Methods CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. Results None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive, rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive, rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant, and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive. In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1

  20.  Motywy wyboru wartości godziwej do wyceny środków trwałych w świetle pozytywnej teorii rachunkowości

    Directory of Open Access Journals (Sweden)

    Katarzyna Bareja

    2016-07-01

    Full Text Available Celem artykułu jest zidentyfikowanie przyczyn wyboru wartości godziwej do wyceny środków trwałych w świetle trzech podstawowych hipotez pozytywnej teorii rachunkowości, sformułowanych przez Wattsa i Zimmermana. Stwierdzono, że podstawowym motywem jest dążenie do poprawy wskaźnika długu do kapitału własnego. W artykule wykorzystano metodę wnioskowania indukcyjnego.

  1.  Spis treści

    Directory of Open Access Journals (Sweden)

    ANNA BARTOSZEWICZ

    2015-03-01

    Full Text Available  Od Zespołu Redakcyjnego – Editorial .......................................................................................................... 7 Anna Bartoszewicz – Praktyczna realizacja Programu zapewnienia i poprawy jakości w komórkach audytu wewnętrznego na wybranych przykładach – Implementation of Quality Assurance and Improvement Program by internal audit teams on selected examples ................................................................ 9 Anna Białek-Jaworska, Natalia Nehrebecka – Struktura kapitałowa przedsiębiorstw w świetle wyników badań – Capital structure of companies in the light of research results ..................... 29 Magda Chraścina – Determinanty tworzenia rezerw oraz ich skutki bilansowo- -wynikowe na przykładzie spółek notowanych na Giełdzie Papierów Wartościowych w Warszawie – Determinants of creating provisions and their effect on the balance sheet and income statement on the example of companies listed on the Warsaw Stock Exchange .................................................................................................. 53 Małgorzata Garstka – Dobry obyczaj jako norma kształtująca zachowanie księgowych – Good practice as a norm shaping the behavior of accountants ...................... 73 Przemysław Kabalski, Joanna Szwajcar – Feminizacja studiów w zakresie rachunkowości w Polsce – przyczyny i skutki – Feminization of accounting studies in Poland – causes and consequences .. 85 Anna Kasperowicz – Znaki i kody rachunkowości w procesie komunikacji – Accounting signs and codes in the communication process .......................... 107 Marcin Kędzior – Dobrowolne stosowanie MSSF przez spółki giełdowe w wybranych krajach Europy Zachodniej – Voluntary adoption of IFRS by listed companies in selected Western European countries ................................................................................................. 123 Ewelina Zarzycka

  2. Por uma ciência do riso e da sabedoria

    Directory of Open Access Journals (Sweden)

    Paula Corrêa Henning

    2010-06-01

    Full Text Available

    O artigo busca problematizar a história das ciências, especialmente o ethos da Modernidade e Pós-modernidade. Para isso, utiliza autores que se anteciparam à Pós-modernidade como Friedrich Nietzsche e Michel Foucault. Na esteira dessa discussão busca uma problematização acerca da Ciência nos rastros da Modernidade e algumas fissuras e fragilidades produzidas na ciência num cenário contemporâneo. Apresenta ainda alguns discursos midiáticos acerca de propagandas televisivas que trazem o discurso científico como legítimo e inabalável. Traz para o campo de discussão uma ciência alegre, como aprendemos com Nietzsche ou prosaica por vezes, anunciando o riso e a sabedoria na produção do conhecimento científico.

     

  3. Previous experience of family violence and intimate partner violence in pregnancy

    Directory of Open Access Journals (Sweden)

    Ana Bernarda Ludermir

    2017-09-01

    Full Text Available ABSTRACT OBJECTIVE To estimate differential associations between the exposure to violence in the family of origin and victimization and perpetration of intimate partner violence in pregnancy. METHODS A nested case-control study was carried out within a cohort study with 1,120 pregnant women aged 18–49 years old, who were registered in the Family Health Strategy of the city of Recife, State of Pernambuco, Brazil, between 2005 and 2006. The cases were the 233 women who reported intimate partner violence in pregnancy and the controls were the 499 women who did not report it. Partner violence in pregnancy and previous experiences of violence committed by parents or other family members were assessed with a standardized questionnaire. Multivariate logistic regression analyses were modeled to identify differential associations between the exposure to violence in the family of origin and victimization and perpetration of intimate partner violence in pregnancy. RESULTS Having seen the mother suffer intimate partner violence was associated with physical violence in childhood (OR = 2.62; 95%CI 1.89–3.63 and in adolescence (OR = 1.47; 95%CI 1.01–2.13, sexual violence in childhood (OR = 3.28; 95%CI 1.68–6.38 and intimate partner violence during pregnancy (OR = 1.47; 95% CI 1.01 – 2.12. The intimate partner violence during pregnancy was frequent in women who reported more episodes of physical violence in childhood (OR = 2.08; 95%CI 1.43–3.02 and adolescence (OR = 1.63; 95%CI 1.07–2.47, who suffered sexual violence in childhood (OR = 3.92; 95%CI 1.86–8.27, and who perpetrated violence against the partner (OR = 8.67; 95%CI 4.57–16.45. CONCLUSIONS Experiences of violence committed by parents or other family members emerge as strong risk factors for intimate partner violence in pregnancy. Identifying and understanding protective and risk factors for the emergence of intimate partner violence in pregnancy and its maintenance may help

  4. Max Weber e a objetividade do conhecimento nas ciências da cultura: um breve guia para o texto A ‘Objetividade’ do Conhecimento na Ciência Social e na Ciência Política (1904

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    Jean Henrique Costa

    2011-05-01

    Full Text Available

    O presente artigo objetiva discutir o sentido da objetividade do conhecimento empírico-social na obra de Max Weber, especificamente no texto “A ‘Objetividade’ do Conhecimento na Ciência Social e na Ciência Política”, de 1904. Discute-se, no primeiro momento, a distinção entre conhecimento empírico e juízo de valor; no segundo momento, faz-se uma rápida crítica às idéias de “lei” e “conexão regular” nas ciências sociais para, em seguida, na terceira parte, discutir a estrutura da formação dos conceitos típico-ideais como recursos metodológicos, nos quais, para Weber, expressam a possibilidade da validade objetiva do conhecimento nas ciências da cultura.

  5. Implications of CI therapy for Visual Deficit Training

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    Edward eTaub

    2014-10-01

    Full Text Available We address here the question of whether the techniques of CI therapy, a family of treatments that has been employed in the rehabilitation of movement and language after brain damage might apply to the rehabilitation of such visual deficits as unilateral spatial neglect and visual field deficits. CI therapy has been used successfully for the upper and lower extremities after chronic stroke, cerebral palsy (CP, multiple sclerosis (MS, other CNS degenerative conditions, resection of motor areas of the brain, focal hand dystonia, and aphasia. Treatments making use of similar methods have proven efficacious for amblyopia.The CI therapy approach consists of four major components: intensive training, training by shaping, a transfer package to facilitate the transfer of gains from the treatment setting to everyday activities, and strong discouragement of compensatory strategies.CI therapy is said to be effective because it overcomes learned nonuse, a learned inhibition of movement that follows injury to the CNS. In addition, CI therapy produces substantial increases in the grey matter of motor areas on both sides of the brain. We propose here that these mechanisms are examples of more general processes: learned nonuse being considered parallel to sensory nonuse following damage to sensory areas of the brain, with both having in common diminished neural connections (DNC in the nervous system as an underlying mechanism. CI therapy would achieve its therapeutic effect by strengthening the diminished neural connections. Use-dependent cortical reorganization is considered to be an example of the more general neuroplastic mechanism of brain structure repurposing (BSR. If the mechanisms involved in these broader categories are involved in each of the deficits being considered, then it may be the principles underlying efficacious treatment in each case may be similar. The lessons learned during CI therapy research might then prove useful for the treatment of

  6. Kuhn e as ciências sociais

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    Jesus de Paula Assis

    1993-12-01

    Full Text Available No texto, são expostos os motivos básicos pelos quais o vocabulário emprestado de Thomas Kuhn - notadamente o termo paradigma - e o modelo de desenvolvimento científico exposto pelo autor em seu A estrutura das revoluções científicas foram tomados de empréstimo em textos que discutem a epistemologia das ciências sociais. A conclusão é que as supostas aplicações do modelo kuhniano às ciências sociais se baseiam em leitura que não encontra qualquer apoio no autor e, principalmente, obscurecem as implicações mais amplas de sua obra.The article shows for what reasons the vocabulary and the model for scientific growth of Thomas Kuhn were borrowed by epistemologists of the social sciences. The conclusion is that the texts produced in this vein are based in a shallow understanding of the author's main implications.

  7. Skinner: sobre ciência e comportamento humano

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    Angelo Augusto Silva Sampaio

    Full Text Available Atualmente, não se pode pensar no estudo do comportamento humano sem considerar a abordagem científica a este objeto: o campo da Psicologia científica. Esse campo é disputado por diversos enfoques teóricos que divergem quanto ao modo como definem ciência e comportamento humano. A abordagem de B. F. Skinner foi bastante proeminente no século XX, mas ainda continua a ser mal-entendida. Partindo do desenvolvimento histórico de sua obra, o presente texto visa a iluminar alguns aspectos relacionados às noções de ciência e comportamento humano desse autor e ressaltar as transformações por que passaram. Analisam-se três tópicos da obra de Skinner: seu período inicial (de 1930 a cerca de 1938, a obra "Ciência e Comportamento Humano" de 1953, e as influências da Biologia. São enfatizados aspectos relevantes da sua teorização sobre o tema: busca por relações funcionais, ênfase nos dados empíricos, operacionismo, externalismo, multideterminação do comportamento, experimentalismo, previsão e controle, ética.

  8. Wartości poznawcze sprawozdawczości regulacyjnej podmiotu świadczącego powszechne usługi pocztowe

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    Leszek Borowiec

    2018-03-01

    Full Text Available Ze względu na aspekty strategiczne, gospodarcze czy społeczne, niektóre obszary aktywności przedsiębiorstw w gospodarce rynkowej są organizowane w ramach tzw. rynków regulowanych. Regulacja danej części rynku najczęściej podlega dodatkowym rygorom sprawozdawczości. Celem artykułu jest próba oceny wartości poznawczych sprawozdawczości z rachunkowości regulacyjnej operatora wyznaczonego do świadczenia powszechnych usług pocztowych. W opracowaniu dokonano przeglądu uwarunkowań prawnych działania operatora wyznaczonego oraz scharakteryzowano zakres ujawnianych informacji w sprawozdawczości regulacyjnej, na przykładzie rynku pocztowych usług powszechnych. Podstawą analizy były sprawozdania regulacyjne składne przez operatora wyznaczonego, tj. Pocztę Polską. Wopracowaniu zastosowano takie metody badawcze jak: studia literaturowe, analiza aktów prawnych regulujących rynek usług pocztowych, wywiady oraz badanie poprzez działanie. Konkluzje skłaniają do stwierdzenia, iż sprawozdawczość regulacyjna, mimo swojej specyfiki, dla regulatora rynku stanowi istotne źródło informacji do oceny efektywności świadczonych usług. Jednocześnie ma bardzo wątpliwe walory poznawcze dla interesariuszy zewnętrznych, ze względu na szeroki zakres stosowania instytucji „tajemnicy przedsiębiorstwa”. Artykuł jest oryginalnym spojrzeniem autora na słabo rozpoznany od strony naukowej problem wartości informacyjnej dla interesariuszy sprawozdawczości podmiotów działających w sektorach regulowanych. For strategic, economic or social reasons, some areas of business activity in the market economy are organized under the so-called regulated markets. The regulation of a given part of the market is most often subject to additional reporting requirements. The aim of this article is to try to assess the cognitive value of reporting from the regulatory accounting of an operator designated to provide universal postal services. The

  9. Electro-chemical coupling in the voltage-dependent phosphatase Ci-VSP

    Science.gov (United States)

    Kohout, Susy C.; Bell, Sarah C.; Liu, Lijun; Xu, Qiang; Minor, Daniel L.; Isacoff, Ehud Y.

    2010-01-01

    In the voltage sensing phosphatase, Ci-VSP, a voltage sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo assay, we find that the inter-domain linker that connects the VSD to the PD is essential for coupling the full-length protein. Biochemical assays show that the linker is also needed for activity in the isolated PD. We identify a late step of VSD motion in the full-length protein that depends on the linker. Strikingly, this VSD motion is found to require PI(4,5)P2, a substrate of Ci-VSP. These results suggest that the voltage-driven motion of the VSD turns the enzyme on by rearranging the linker into an activated conformation, and that this activated conformation is stabilized by PI(4,5)P2. We propose that Ci-VSP activity is self-limited because its decrease of PI(4,5)P2 levels decouples the VSD from the enzyme. PMID:20364128

  10. Measurement of Small Values of Hydrostatic Pressure with the Compensation of Atmospheric Pressure Influence / Pomiar Małych Wartości Ciśnienia Hydrostatycznego Z Kompensacją Wpływu Ciśnienia Atmosferycznego

    Science.gov (United States)

    Broda, Krzysztof; Filipek, Wiktor

    2013-09-01

    Knowledge of pressure distribution (or differential pressure ) determines the fluid flow description through the porous medium. In the case of big Reynolds numbers it is not difficult, but for laminar flows (i.e. for Re numbers Bear, 1988; Duckworth, 1983; Troskolański, 1957) from the scope 0.01 to 3) this description is virtually impossible on the basis of the tools available on the market. The previous study (Broda & Filipek, 2012) focused on the difficulty of measurement in the case of small differences of pressure and suggested a new original method for the measurement. A new unit for the measurement was constructed consisting of two separate measurement containers. Then the measurements were conducted, which necessitated temperature stabilization of the device and compensation of the atmospheric pressure influence on the measurement process. This paper presents the results of the continuation of research concerning the methods and equipment for the measurement of very small pressure differences. The paper includes also the experience gained from the new measurement unit, which was presented in figures 1-5 subsequently presenting the concept of measurement of small values of hydrodynamic pressure with compensation of atmospheric pressure influence fig. 1; illustration presenting the state corresponding to the case of the lack of flow through the tested item fig 2; state corresponding to the fluid flow through the tested item fig. 3; then the description of the measurement of pressure drop on the tested item fig. 4 and the measurement methodology (relations (1) - (20)). Picture of the measurement unit and its components - fig. 5. Furthermore, the authors present an exemplary measurement series and focus on the method of measurement and data processing - tables 1-8 and figures 6-8. Table 4 presents the comparison of the measurement unit used in the previous research (Broda & Filipek, 2012) and the new one - presented in the paper. It should be noted that the

  11. BIOGRAMY POLSKICH MYŚLICIELI NIERUCHOMOŚCI

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    Edyta Łazarowicz

    2009-11-01

    Full Text Available Fragment artykułu: [b]Andrzej Bieniek[/b] (1895-1944, doktor, urodził się 17 października 1895 r. w Bratucicach (powiat Bochnia, rozstrzelany 26 lipca 1944 roku w ruinach getta w Warszawie. (...Doktor A. Bieniek zajmował się głównie problemami organizacji księgowości w przedsiębiorstwach oraz rachunkiem kosztów. Był autorem m.in. następujących publikacji: Polska metoda księgowości oparta na ekonomicznym systemie Taylora (Biblioteka Państwowej Szkoły Handlowej Męskiej w Łodzi, Łódź 1927, Kantor wzorowy w szkołach handlowych (Biblioteka Państwowej Szkoły Handlowej Męskiej w Łodzi, Warszawa-Łódź 1928, Księgowość w przedsiębiorstwach przemysłowych (Biblioteka Rady Głównej Zrzeszeń Księgowych i Rzeczoznawców Księgowości w Polsce, Warszawa 1935, Zasady inwentaryzacji i bilansowania (Związek Księgowych w Polsce, Warszawa 1936, Organizacja rachunkowości w przedsiębiorstwach przemysłowych ((Związek Księgowych w Polsce, Warszawa 1939, Zasady analizy bilansów (Stowarzyszenie Nauczycieli Szkół Zawodowych. Sekcja Główna Handlowa, Warszawa 1939. [b]Zygmunt Stefan Kossut[/b] (1922–1984 profesor doktor habilitowany, syn Wiktora Kossuta i Henryki Serafin, urodził się 16 kwietnia 1922 r. (.. Do dzisiaj znane jest profesjonalistom zdanie E. Terebuchy, że „on pierwszy (Z. Kossut – M.G. przeorał ugór w naszej nauce rachunkowości, wykonując próbę sformułowania nowych poglądów na metody badawcze w dziedzinie teorii rachunkowości.” [b]Kazimierz Sowa[/b] (1915–1972, profesor nadzwyczajny, doktor, urodził się 2 października 1915 roku w Krakowie w rodzinie chłopskiej, zmarł 17 grudnia 1972 r. w Krakowie. Był żonaty, bezdzietny. (... Okres pracy zawodowej Kazimiera Sowy (1938–1972 był bardzo zróżnicowany i przebiegał wielotorowo. Była to praca naukowo-dydaktyczna w szkolnictwie wyższym, praca redakcyjno-popularyzatorska, organizacyjno-kierownicza w Stowarzyszeniu Księgowych w

  12. The prevalence of previous self-harm amongst self-poisoning patients in Sri Lanka

    DEFF Research Database (Denmark)

    Mohamed, Fahim; Perera, Aravinda; Wijayaweera, Kusal

    2011-01-01

    BACKGROUND: One of the most important components of suicide prevention strategies is to target people who repeat self-harm as they are a high risk group. However, there is some evidence that the incidence of repeat self-harm is lower in Asia than in the West. The objective of this study...... was to investigate the prevalence of previous self-harm among a consecutive series of self-harm patients presenting to hospitals in rural Sri Lanka. METHOD: Six hundred and ninety-eight self-poisoning patients presenting to medical wards at two hospitals in Sri Lanka were interviewed about their previous episodes...... of self-harm. RESULTS: Sixty-one (8.7%, 95% CI 6.7-11%) patients reported at least one previous episode of self-harm [37 (10.7%) male, 24 (6.8%) female]; only 19 (2.7%, 95% CI 1.6-4.2%) patients had made more than one previous attempt. CONCLUSION: The low prevalence of previous self-harm is consistent...

  13. O TOŻSAMOŚCI I POLITYCE

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    Katarzyna Warmińska

    2015-03-01

    Full Text Available Ostatnie dekady przyniosły znaczące zmiany w sferze stosunków etnicznych w Polsce. Można było zaob- serwować wzrastającą aktywność społeczności mniejszościowych, które stają się w coraz większym stopniu aktywnymi, coraz lepiej zorganizowanymi aktorami na scenie publicznej. W bardziej otwarty sposób komunikują swoje potrzeby, cele i wizje świata. Chcąc uchwycić istotę tych przemian postanowiłam zaaplikować, do ich analizy, koncepcję polityki tożsamości. Moim celem jest ukazanie swoistej „logiki” działania politycznego grup tożsamościowych, ze szczególnym uwzględnieniem jego wymiaru etnicznego z jednoczesnym wskazaniem na pożytek z zastosowania tego pojęcia do analizy zjawisk etnicznych w Polsce. Jako empiryczną egzemplifikację potraktowałam społeczność kaszubską.

  14. Ciências da Religião numa sociedade multicultural

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    Wolfgang Gruen

    2009-05-01

    Full Text Available Texto originalmente apresentado como aula inaugural do Programa de Pós-graduação em Ciências da Religião da PUC Minas. Trata da epistemologia e dos desafios da investigação em Ciências da Religião. Partindo do problema de base da religiosidade na Educação, do fenômeno religioso e sua dimensão profunda, o artigo segue uma densa investigação sobre os limites e horizontes das Ciências da Religião.Palavras-chave: Ciências da Religião; Religião; Religiosidade; Educação; Ensino religioso.ABSTRACTThis text was originally presented as the opening class of the Postgraduate Programme in Sciences of Religion of PUC Minas. It concerns the epistemology and challenges of investigation in Sciences of Religion. Starting from the fundamental question of religiosity in Education, of the religious phenomenon and its deep dimension, the article embarks on a close investigation into the limits and horizons of the Sciences of Religion.Key words: Sciences of religions; Religion; Religiosity; Education; Religious teaching.

  15. Increased risk of default among previously treated tuberculosis cases in the Western Cape Province, South Africa.

    Science.gov (United States)

    Marx, F M; Dunbar, R; Hesseling, A C; Enarson, D A; Fielding, K; Beyers, N

    2012-08-01

    To investigate, in two urban communities with high tuberculosis (TB) incidence and high rates of TB recurrence, whether a history of previous TB treatment is associated with treatment default. Retrospective cohort study of TB cases with an episode of treatment recorded in the clinic-based treatment registers between 2002 and 2007. Probabilistic record linkage was used to ascertain treatment history of TB cases back to 1996. Based on the outcome of their most recent previous treatment episode, previously treated cases were compared to new cases regarding their risk of treatment default. Previous treatment success (adjusted odds ratio [aOR] 1.79; 95%CI 1.17-2.73), previous default (aOR 6.18, 95%CI 3.68-10.36) and previous failure (aOR 9.72, 95%CI 3.07-30.78) were each independently associated with treatment default (P default were male sex (P = 0.003) and age 19-39 years (P risk of treatment default, even after previous successful treatment. This finding is of particular importance in a setting where recurrent TB is very common. Adherence to treatment should be ensured in new and retreatment cases to increase cure rates and reduce transmission of TB in the community.

  16. Technical note: A new day- and night-time Meteosat Second Generation Cirrus Detection Algorithm MeCiDA

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    W. Krebs

    2007-12-01

    Full Text Available A new cirrus detection algorithm for the Spinning Enhanced Visible and Infra-Red Imager (SEVIRI aboard the geostationary Meteosat Second Generation (MSG, MeCiDA, is presented. The algorithm uses the seven infrared channels of SEVIRI and thus provides a consistent scheme for cirrus detection at day and night. MeCiDA combines morphological and multi-spectral threshold tests and detects optically thick and thin ice clouds. The thresholds were determined by a comprehensive theoretical study using radiative transfer simulations for various atmospheric situations as well as by manually evaluating actual satellite observations. The cirrus detection has been optimized for mid- and high latitudes but it could be adapted to other regions as well. The retrieved cirrus masks have been validated by comparison with the Moderate Resolution Imaging Spectroradiometer (MODIS Cirrus Reflection Flag. To study possible seasonal variations in the performance of the algorithm, one scene per month of the year 2004 was randomly selected and compared with the MODIS flag. 81% of the pixels were classified identically by both algorithms. In a comparison of monthly mean values for Europe and the North-Atlantic MeCiDA detected 29.3% cirrus coverage, while the MODIS SWIR cirrus coverage was 38.1%. A lower detection efficiency is to be expected for MeCiDA, as the spatial resolution of MODIS is considerably better and as we used only the thermal infrared channels in contrast to the MODIS algorithm which uses infrared and visible radiances. The advantage of MeCiDA compared to retrievals for polar orbiting instruments or previous geostationary satellites is that it permits the derivation of quantitative data every 15 min, 24 h a day. This high temporal resolution allows the study of diurnal variations and life cycle aspects. MeCiDA is fast enough for near real-time applications.

  17. Detection of CI line emission towards the oxygen-rich AGB star omi Ceti

    Science.gov (United States)

    Saberi, M.; Vlemmings, W. H. T.; De Beck, E.; Montez, R.; Ramstedt, S.

    2018-05-01

    We present the detection of neutral atomic carbon CI(3P1-3P0) line emission towards omi Cet. This is the first time that CI is detected in the envelope around an oxygen-rich M-type asymptotic giant branch (AGB) star. We also confirm the previously tentative CI detection around V Hya, a carbon-rich AGB star. As one of the main photodissociation products of parent species in the circumstellar envelope (CSE) around evolved stars, CI can be used to trace sources of ultraviolet (UV) radiation in CSEs. The observed flux density towards omi Cet can be reproduced by a shell with a peak atomic fractional abundance of 2.4 × 10-5 predicted based on a simple chemical model where CO is dissociated by the interstellar radiation field. However, the CI emission is shifted by 4 km s-1 from the stellar velocity. Based on this velocity shift, we suggest that the detected CI emission towards omi Cet potentially arises from a compact region near its hot binary companion. The velocity shift could, therefore, be the result of the orbital velocity of the binary companion around omi Cet. In this case, the CI column density is estimated to be 1.1 × 1019 cm-2. This would imply that strong UV radiation from the companion and/or accretion of matter between two stars is most likely the origin of the CI enhancement. However, this hypothesis can be confirmed by high-angular resolution observations.

  18. Combining the Complete Active Space Self-Consistent Field Method and the Full Configuration Interaction Quantum Monte Carlo within a Super-CI Framework, with Application to Challenging Metal-Porphyrins.

    Science.gov (United States)

    Li Manni, Giovanni; Smart, Simon D; Alavi, Ali

    2016-03-08

    A novel stochastic Complete Active Space Self-Consistent Field (CASSCF) method has been developed and implemented in the Molcas software package. A two-step procedure is used, in which the CAS configuration interaction secular equations are solved stochastically with the Full Configuration Interaction Quantum Monte Carlo (FCIQMC) approach, while orbital rotations are performed using an approximated form of the Super-CI method. This new method does not suffer from the strong combinatorial limitations of standard MCSCF implementations using direct schemes and can handle active spaces well in excess of those accessible to traditional CASSCF approaches. The density matrix formulation of the Super-CI method makes this step independent of the size of the CI expansion, depending exclusively on one- and two-body density matrices with indices restricted to the relatively small number of active orbitals. No sigma vectors need to be stored in memory for the FCIQMC eigensolver--a substantial gain in comparison to implementations using the Davidson method, which require three or more vectors of the size of the CI expansion. Further, no orbital Hessian is computed, circumventing limitations on basis set expansions. Like the parent FCIQMC method, the present technique is scalable on massively parallel architectures. We present in this report the method and its application to the free-base porphyrin, Mg(II) porphyrin, and Fe(II) porphyrin. In the present study, active spaces up to 32 electrons and 29 orbitals in orbital expansions containing up to 916 contracted functions are treated with modest computational resources. Results are quite promising even without accounting for the correlation outside the active space. The systems here presented clearly demonstrate that large CASSCF calculations are possible via FCIQMC-CASSCF without limitations on basis set size.

  19. Dyskusja wokół celu sprawozdawczości finansowej opartej na MSSF

    Directory of Open Access Journals (Sweden)

    Edyta Łazarowicz

    2016-07-01

    Full Text Available Celem artykułu jest analiza i ocena propozycji zmian odnośnie do celu sprawozdawczości finansowej opartej na Międzynarodowych Standardach Sprawozdawczości Finansowej (MSSF przedstawionych w komentarzach do projektu Założeń koncepcyjnych sprawozdawczości finansowej (2015. Większość respondentów uważa, że w celu sprawozdawczości finansowej należy zwiększyć znaczenie dostarczania informacji o wypełnieniu funkcji powierniczej przez kierownictwo (stewardship. Ponadto proponują oni przedstawienie definicji stewardship w Założeniach koncepcyjnych oraz wskazanie konsekwencji zmiany celu sprawozdawczości finansowej dla przyszłego tworzenia standardów i dla sporządzania sprawozdań finansowych. Z analizy komentarzy i przeglądu literatury wynika, że cel sprawozdawczości finansowej powinien być zmieniony. Sprawą dyskusyjną pozostaje jednak, czy stewardship powinien być odrębnym celem. Niestety, jest za mało badań dotyczących relacji pomiędzy stewardship i użytecznością decyzyjną. Ich wyniki mogłyby wskazać twórcom standardów rachunkowości potencjalne kompromisy i konflikty między nimi.

  20. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer (NMSC): A population-based study.

    Science.gov (United States)

    Fischer, Alexander H; Wang, Timothy S; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L

    2016-08-01

    Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit ultraviolet exposure. We sought to determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (CI), taking into account the complex survey design. Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% vs 27.0%; aPOR 1.41; 95% CI 1.16-1.71), long sleeves (20.5% vs 7.7%; aPOR 1.55; 95% CI 1.21-1.98), a wide-brimmed hat (26.1% vs 10.5%; aPOR 1.52; 95% CI 1.24-1.87), and sunscreen (53.7% vs 33.1%; aPOR 2.11; 95% CI 1.73-2.59), but did not have significantly lower odds of recent sunburn (29.7% vs 40.7%; aPOR 0.95; 95% CI 0.77-1.17). Among those with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Self-reported cross-sectional data and unavailable information quantifying regular sun exposure are limitations. Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  1. Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density

    Science.gov (United States)

    Richards, Neil; Parker, David S.; Johnson, Lisa A.; Allen, Benjamin L.; Barolo, Scott; Gumucio, Deborah L.

    2015-01-01

    The Hedgehog (Hh) signaling pathway directs a multitude of cellular responses during embryogenesis and adult tissue homeostasis. Stimulation of the pathway results in activation of Hh target genes by the transcription factor Ci/Gli, which binds to specific motifs in genomic enhancers. In Drosophila, only a few enhancers (patched, decapentaplegic, wingless, stripe, knot, hairy, orthodenticle) have been shown by in vivo functional assays to depend on direct Ci/Gli regulation. All but one (orthodenticle) contain more than one Ci/Gli site, prompting us to directly test whether homotypic clustering of Ci/Gli binding sites is sufficient to define a Hh-regulated enhancer. We therefore developed a computational algorithm to identify Ci/Gli clusters that are enriched over random expectation, within a given region of the genome. Candidate genomic regions containing Ci/Gli clusters were functionally tested in chicken neural tube electroporation assays and in transgenic flies. Of the 22 Ci/Gli clusters tested, seven novel enhancers (and the previously known patched enhancer) were identified as Hh-responsive and Ci/Gli-dependent in one or both of these assays, including: Cuticular protein 100A (Cpr100A); invected (inv), which encodes an engrailed-related transcription factor expressed at the anterior/posterior wing disc boundary; roadkill (rdx), the fly homolog of vertebrate Spop; the segment polarity gene gooseberry (gsb); and two previously untested regions of the Hh receptor-encoding patched (ptc) gene. We conclude that homotypic Ci/Gli clustering is not sufficient information to ensure Hh-responsiveness; however, it can provide a clue for enhancer recognition within putative Hedgehog target gene loci. PMID:26710299

  2. (Human) Resourcing For CI

    DEFF Research Database (Denmark)

    Jørgensen, Frances; S., Jacob; Kofoed, Lise Busk

    2005-01-01

    the change processes in which we are engaged?” Without a clear picture of the types of competencies required to implement CI, it is impossible for companies to make informed decisions regarding recruitment, hiring, and training of their workforce. The objective of this paper is therefore to define...... and characterize the types of competencies necessary for persons involved change implementation. Data collection involved interviews and observations in three longitudinal studies in five companies based in Denmark. From these data, a list of competencies that appeared to facilitate CI implementation was compiled...... challenging in organizations involved in change processes such as Continuous Improvement (CI), as the technical skills traditionally valued are no longer adequate. These companies are faced with the question: “What competencies should our employees possess in order to contribute to our success, given...

  3. Convergências entre a Ciência da Informação e as Ciências Cognitivas

    Directory of Open Access Journals (Sweden)

    Aida Varela Varela

    2016-06-01

    Full Text Available Apresentam-se as convergências entre a Ciência da Informação e as Ciências Cognitivas, buscando argumentos, fundamentos para fomentar e produzir o saber e o fazer, potencializando estudos e aproximações. Para tal, reflete-se sobre conhecimentos e necessidades, os principais representantes das correntes cognitivas, como substrato aos processos de recuperação, compreensão, reflexão e criticidade essenciais à construção do conhecimento científico, com destaque para o domínio dos vários níveis de leitura para buscar e usar a informação. Utiliza-se como metodologia revisão bibliográfica, com estabelecimento de diálogos com autores clássicos e contemporâneos das áreas em questão. Conclui-se que é preciso se destacar o caráter paradigmático, bem como outras dimensões das construções conceituais e práticas das duas áreas em foco, principalmente os concentrar as pesquisas nos estudos cognitivos para subsidiar a busca da informação com autonomia e garantia de desenvolvimento pessoal, com maior contribuição num contexto de constantes mudanças.

  4. Ukaegbe, CI

    African Journals Online (AJOL)

    Ukaegbe, CI. Vol 11, No 1-2 (2012) - Articles Postpartum Depression Among Igbo Women In An Urban Mission Hospital, South East Nigeria Abstract. ISSN: 1597-1260. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  5. Kontrowersje w leczeniu dietetycznym otyłości

    Directory of Open Access Journals (Sweden)

    Irena Białokoz-Kalinowska

    2009-03-01

    Full Text Available Otyłość jest zjawiskiem coraz częściej występującym na świecie. Szacuje się, że ponad połowę dorosłej populacji krajów uprzemysłowionych dotknęła nadwaga, a odsetek otyłości w niektórych krajach (USA, Wielka Brytania wzrasta do 30%. Ta niepokojąca tendencja obserwowana jest również w populacji dzieci i młodzieży. Epidemia otyłości rozpoczęła się w latach 80. i trwa nieprzerwanie do chwili obecnej, stając się poważnym problemem społeczno-medycznym współczesnego świata. Przyczyny tego zjawiska są złożone i wynikają z uwarunkowań biologicznych i środowiskowych, w szczególności z niedostatecznej codziennej aktywności fizycznej oraz złych nawyków żywieniowych. Do tej pory nie udało się wypracować w pełni efektywnej strategii leczenia otyłości. Promocja zdrowego stylu życia oraz właściwych nawyków żywieniowych adresowana do całej populacji stanowi podstawę prewencji i leczenia otyłości. Powszechnie stosowane różnego rodzaju diety odchudzające zawierają często sprzeczne zalecenia. Istniejące kontrowersje utrudniają wybór skutecznej diety w celu redukcji masy ciała, a ich mnogość i różnorodność wprowadzają swoisty chaos informacyjny. Efekty wielu diet są krótkotrwałe i obarczone efektem jo-jo. W wielu przypadkach brak jest jakichkolwiek przesłanek naukowych uzasadniających dane postępowanie dietetyczne. Właśnie dlatego wciąż istnieje potrzeba prowadzenia dalszych badań naukowych umożliwiających w sposób obiektywny ocenę skuteczności dietetycznych metod leczenia otyłości. W niniejszej pracy autorzy przedstawiają spotykane w praktyce różne dietetyczne podejścia do problemu otyłości, wskazując na ich efektywność i naukowe uzasadnienie.

  6. Clinical presentation of acute coronary syndrome in patients previously treated with nitrates.

    Science.gov (United States)

    Latour-Pérez, Jaime; Gómez-Tello, Vicente; Fuset-Cabanes, María Paz; Balsa, Eva de Miguel; Sáez, Frutos Del Nogal; Orts, Francisco Javier Coves; Rodríguez, Carmen Martín; Pino-Izquierdo, Karel; Pesquera, María de la Concepción Pavía; Rodríguez, Antonio José Montón

    2013-11-01

    Several reports have suggested that nitrates limit acute ischaemic damage by a mechanism similar to preconditioning. This study aims to evaluate the effect of chronic oral nitrates on the clinical presentation and short-term outcomes of patients admitted with acute coronary syndrome (ACS). A retrospective cohort study was conducted in patients with ACS admitted to 62 acute care units from 2010 to 2011. A propensity score-matched samples analysis was performed. We analysed 3171 consecutive patients, of whom 298 (9.4%) were chronically treated with nitrates. Patients previously treated with nitrates had higher comorbidity and disease severity at admission, lower prevalence of ACS with ST elevation, lower troponin elevation, higher prevalence of initial Killip class 2-4 and higher hospital mortality. The propensity score-matched analysis confirmed that previous use of nitrates is independently associated with a lower prevalence of ST-elevation ACS [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.36-0.78; P = 0.0014] and a lower troponin elevation (OR 0.61, 95% CI 0.41-0.92) but not with Killip class on admission (OR 1.18, 95% CI 0.83-1.67, P = 0.3697) or mortality (OR 0.71, 95% CI 0.37-1.38, P = 0.3196). The results support the hypothesis that nitrates have a protective effect on acute ischaemic injury.

  7. Isenção da ciência, neutralidade da análise

    Directory of Open Access Journals (Sweden)

    Daniel Menezes Coelho

    2012-01-01

    Full Text Available O artigo discute as relações entre a psicanálise e a ciência, especialmente no que tange aos seus métodos de investigação e trabalho. Para isso, tomamos como objeto a noção de neutralidade, tal como podemos apreendê-la na clínica da psicanálise, para confrontá-la com o que chamamos de isenção no campo da ciência, que não quer dizer outra coisa que a neutralidade proposta lá. Veremos que, apesar da clara filiação da noção psicanalítica para com a noção vinda da ciência, a neutralidade clínica da psicanálise toma outro rumo, que se pode mesmo opor ao sentido do termo na ciência. Enquanto em ciência o termo quer significar um processo de purificação e de seleção, em psicanálise ele surge como a exigência de nada selecionar.

  8. Scyntygrafia kości w diagnostyce reumatoidalnego zapalenia stawów

    Directory of Open Access Journals (Sweden)

    Witold Tłustochowicz

    2010-04-01

    Full Text Available Celem pracy była ocena przydatności trójfazowej dynamicznejscyntygrafii kości w diagnostyce reumatoidalnego zapalenia stawów.Badaniem objęto 39 chorych hospitalizowanych i diagnozowanychz powodu dolegliwości stawowych. Przeprowadzono diagnostykęobejmującą: badanie podmiotowe, przedmiotowe, badania laboratoryjneoraz obrazowe, w tym trójfazową scyntygrafię kości z użyciemtechnetu 99m. Scyntygraficzne cechy zapalenia stawówstwierdzano, gdy obserwowano wzmożone gromadzenie znacznikawe wszystkich trzech fazach badania.Po ukończeniu diagnostyki rozpoznano u 13 chorych wczesne reumatoidalnezapalenie stawów, u 4 reumatoidalne zapalenie stawów(łącznie 17 pacjentów, a u 1 niezróżnicowane zapalenie stawów.Scyntygrafia kości wykazała cechy zapalenia stawów u 13spośród nich (72,2%, u 4 osób (22,2% wzmożone gromadzeniestwierdzono tylko w fazie statycznej, a u 1 pacjenta (5,6% uzyskanoprawidłowy wynik badania. U 21 chorych wykluczono chorobęzapalną stawów (u 19 rozpoznano fibromialgię, u 2 chorobęzwyrodnieniową. W grupie bez zapalenia stawów u 14 pacjentów(66,6% nie stwierdzono istotnych nieprawidłowości w obraziescyntygraficznym, u 6 (28,6% występowało wzmożone gromadzenieznacznika w badaniu statycznym, a u 1 chorego (4,8% opisanoscyntygraficzne cechy zapalenia stawów.Wbadanej grupie czułość scyntygrafii dynamicznej kości w wykrywaniuzapalenia stawów wynosiła 72,2% (95% CI: 57,5–76,8, a swoistość 95,2% (95% CI: 82,8–99,1. Dodatni wynik badaniadynamicznego wskazuje z dużym prawdopodobieństwem naobecność zapalenia stawów [PPV 92,9% (95% CI: 74,2–98,7].Mniej wiarygodny był ujemny wynik badania [NPV 80% (95% CI:69,5–83,3]. Wyniki niniejszej pracy wskazują, że trójfazowa scyntygrafia dynamicznakości może mieć zastosowanie w diagnostyce reumatoidalnegozapalenia stawów.

  9. PENGUASAAN KERAJAAN TARUMANEGARA TERHADAP KAWASAN HULU CI SADANE THE CONTROL OF TARUMANEGARA KINGDOM TO THE CI SADANE UPSTREAM AREA

    Directory of Open Access Journals (Sweden)

    Endang Widyastuti

    2016-06-01

    Full Text Available ABSTRACT As we know that the oldest kingdom in West Java is the Kingdom Tarumanegara. Authentic evidence of the existence of such is the kingdom of seven inscriptions, of which five were found in the upstream region is now administratively Cisadane including Bogor regency. Three of the five inscriptions indicate the possession of territory by Tarumanegara kingdom. This indicates that the upstream region Cisadane is an area that is quite important and has the potential to be controlled by Tarumanegara.   Key words:upstream of Ci Sadane, Tarumanegara kingdom, control area   ABSTRAK Sebagaimana diketahui bahwa kerajaan tertua di Jawa Barat adalah Kerajaan Tarumanegara. Bukti otentik mengenai keberadaan kerajaan tersebut adalah adanya tujuh prasasti, yang lima diantaranya ditemukan di kawasan Hulu Cisadane yang sekarang secara administratif termasuk wilayah Kabupaten Bogor. Tiga diantara kelima prasasti tersebut menunjukkan penguasaan wilayah tersebut oleh Kerajaan Tarumanegara. Hal ini mengindikasikan bahwa kawasan hulu cisadane merupakan kawasan yang cukup penting dan mempunyai potensi yang harus dikuasai oleh Tarumanegara.   Kata Kunci:hulu Ci Sadane, Kerajaan Tarumanegara, penguasaan wilayah.

  10. Luz, arte, ciência... ação! Lights, art, science - action!

    Directory of Open Access Journals (Sweden)

    Thelma Lopes

    2005-01-01

    Full Text Available O principal objetivo do presente artigo é refletir sobre as principais interações entre teatro, ciência e tecnologia, ao longo da história do teatro, e discutir, a partir de nossa experiência no Ciência em Cena, espaço integrante do Museu da Vida, de que modos essas interações podem estar presentes no cotidiano de um museu de ciências. A palavra 'ciência' deve ser compreendida aqui em sentido amplo, englobando não apenas as ciências naturais, mas também as ciências humanas, assim como a palavra 'tecnologia' deve ser associada à ciência aplicada. Arte e ciência serão entendidas como processos criativos, como formas de representação do mundo e expressão do conhecimento humano.The article offers some reflections on the main interactions between theater, science, and technology down through the history of theater. Based on our experience at "Science in the Spotlight", part of the Casa de Oswaldo Cruz's Museum of Life, we discuss how these interactions can be part of a science museum's daily activities. We use the word 'science' in its broad sense, encompassing not only the natural but human sciences as well; likewise, we use the word 'technology' as it relates to applied science. Art and science are understood here as creative processes, as ways of representing the world and expressing human knowledge.

  11. Identyfikacja wielokryterialnego modelu istotności pompowni melioracyjnych na terenie Polski

    Directory of Open Access Journals (Sweden)

    Wojciech Sałabun

    2015-09-01

    Full Text Available Niniejsza praca omawia istotny problem związany z klasyfikacją i właściwym zdefiniowaniem wielkości pompowni melioracyjnych. Podstawowa definicja wielkości jest bardzo szeroka, zatem ze względu na liczbę objaśniających ją parametrów wymaga precyzyjnego uściślenia. W dotychczasowych ocenach rozmiarów pompowni melioracyjnych posługiwano się na ogół wrażeniami osobistymi opartymi na subiektywnym odczuciu, które z kolei jest oparte na nieznanej liczbie parametrów. Pojawiające się przy tym trudności z określeniem przynależności obiektów do danej grupy wielkości wynikały głównie z luk informacyjnych dotyczących właściwej granicy podziału pomiędzy poszczególnymi grupami. W niniejszej pracy, do klasyfikacji i podziału pompowni według ich wielkości zastosowano takie ich parametry jak: moc nominalna pompowni P w kW, wydajność całkowita Q w m3 · s oraz zasięg oddziaływania pompowni Fp w ha, dla 270 losowo wybranych obiektów melioracyjnych w Polsce. Do rozwiązania problemu wykorzystano jedną z wielokryterialnych metod podejmowania decyzji (MCDM, opartą na mechanizmach logiki rozmytej, noszącą nazwę metody obiektów charakterystycznych (COMET.

  12. A ciência no espaço educacional da criança: do fazer ciência à ciência do fazer

    Directory of Open Access Journals (Sweden)

    Carolina Rodrigues de Souza

    2016-05-01

    Full Text Available This article aims to reflect on the possible articulations of the development of science in the education of children and their respective childhoods. While in Kindergarten and Elementary School students are, above all, children, and as such, subjects endowed with intelligence, emotions, and feelings. They are able to make observations, retain information, propose arguments, participate in discussions, and make choices that allow them to exercise free expression of theirs thoughts in many different languages. However, to ensure the effective participation of the child as a subject of today, not an intented being, it is necessary to reconsider the actions and relationships in the school environment. In this sense, this study highlights contributions on how the educational process of science can/should be thought in the process of children education. Also, we hope to provide access to scientific culture without detracting the childhoods. We highlight the possibility of using some powerful elements of science in the school environment to sharpen curiosity and improve new worldviews. Often different from the adult perspective, science in children education should emphasize issues such as the specificity of child logic, which encompasses creativity, imagination, fantasy, and desire. This article, in its theoretical nature, discusses notions such as childhood, children, and science in order to consider a type of early childhood education in which an educational routine with elements of scientific culture would enable the occurrence of childhood practice. Este artigo objetiva refletir sobre as possíveis articulações do desenvolvimento das ciências na educação das crianças e suas respectivas infâncias e parte da compreensão de que na Educação Infantil e nos primeiros anos do Ensino Fundamental, os estudantes antes de alunos são crianças, e como tais, são sujeitos completos, dotados de inteligência, emoções e sentimentos; capazes de

  13. Między pamięcią a zapomnieniem Shoah. Problem estetycznej neutralizacji przeszłości w myśleniu historycznym Saula Friedländera

    Directory of Open Access Journals (Sweden)

    Sawicki, Maciej

    2015-06-01

    Full Text Available W tekstach Saula Friedländera problem indywidualnej pamięci Shoahstanowił jedną z głównych granic dla dyskursu. Punktem krytycznym jego refleksji nad pamięcią stała się kwestia społecznego myślenia zbawczego, które stanowiło reakcję obronną wobec katastrofy. Fenomen ten ujawnił się szczególnie wyraźnie w publicznej formie pamięci, która z jednej strony domagała się prostoty i jasnej interpretacji, jako że jej zadaniem było oswojenie niekoherencji, wyeliminowanie bólu oraz rozbudzenie nadziei u współczesnych; z drugiej strony indywidualna pamięć głęboka ocalałych – nie znająca zasad – nie godziła się na formę pamięci publicznej, mimo że nie była w stanie jej się oprzeć. Według Friedländera ekspansja pamięci publicznej i zanikanie pamięci indywidualnej sprawia, iż "pamięć Shoah prawdopodobnie nie ucieknie przed całkowitą rytualizacją"1. W swoich rozważaniach częstokroć zwracał on uwagę na to, że sztuka nie może przeciwdziałać oswajaniu grozy, ponieważ musi wyrażać indywidualną pamięć przeszłości w pewnych prostych formach. Oprócz tego problematyczny stał się fakt, że same kategorie sztuki po Holokauście zostały zawładnięte przez przemysł kulturowy i politykę, przez co problem pamięci stał się środkiem przetargowym dla innych celów. Nawiązując za Friedländerem do aktualnego impasu wobec różnych oswajających mechanizmów pamięci, spróbuję poddać pod rozwagę kwestię granic i możliwości w tworzeniu estetycznego pomostu między teraźniejszością a przeszłością.

  14. Notas sobre o autotelismo discursivo em ciências humanas

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Lopes

    1994-12-01

    Full Text Available O Ateliê de Semiótica Discursiva, coordenado por Denis Bertrand, propôs focalizar, no ano letivo 1991-1992, a " Estética do Discurso Erudito", no quadro da temática "Estética da Ética" do Seminário de Semântica Geral, de A.J . Greimas, na Escola de Altos Estudos em Ciências Sociais de Paris (E. H. E. S. S.. Bertrand distribuiu cópias de trechos de textos célebres em ciências humanas (Lévi-Strauss, Deleuze e Guattari, Greimas, Barthes, Foucault e outros, sobre os quais os participantes deveriam realizar análises que tomassem como modelo, por exemplo, aquelas praticadas por Greimas e Landowski em lntroduction à L 'Analyse du Discours en Sciences Sociales ( 1979.

  15. Analiza wielkości i zmienności zużycia wody w kampusie Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie

    Directory of Open Access Journals (Sweden)

    Piotr Wichowski

    2015-10-01

    Full Text Available W artykule przedstawiono badania wielkości i zmienności zużycia wody w kampusie SGGW w roku akademickim 2012/13. Przeciętne jednostkowe zużycie wody w okresie, kiedy realizowane są zajęcia dydaktyczne, wyniosło 29,3 dm3·d–1 dla studenta studiów stacjonarnych i 23,2 dm3·d–1 dla studenta studiów niestacjonarnych. W okresie wakacyjnym wskaźniki te są niższe i wynoszą odpowiednio 15,2 oraz 11,4 dm3·d–1. Wskaźniki te wyznaczono bez uwzględnienia zużycia wody w akademikach. Współczynnik nierównomierności dobowej dla całego kampusu wyniósł 1,54 i był zbliżony do współczynnika nierównomierności godzinowej, wynoszącego 1,52. Najwyższe miesięczne zużycie wody wystąpiło w czerwcu i było o 85% większe od najniższego, które wystąpiło w sierpniu. W cyklu tygodniowym najwyższe zużycie wody obserwowano we wtorki, a najniższe w niedziele. Przeciętne rozbiory wtorkowe są wyższe od rozbiorów niedzielnych o 31,5%. Szczyty rozbiorów w ciągu doby przypadały w godzinach 10–15 oraz 23–01.

  16. Ciência da Computação

    Directory of Open Access Journals (Sweden)

    André Felipe Henriques Librantz

    2006-01-01

    Full Text Available Este trabalho apresenta um sistema de navegação autônoma de robôs construídos com kits Lego Mindstorms, para cálculo de trajetórias. Esse sistema pode ser utilizado como instrumento pedagógico multidisciplinar no curso de Ciência da Computação, uma vez que, para o seu desenvolvimento são necessários conhecimentos de algoritmos, linguagem de programação, lógica computacional, estrutura de dados, inteligência artificial (IA, redes de computadores, computação gráfica e robótica.

  17. Uwarunkowania skuteczności działania inkubatorów przedsiębiorczości

    OpenAIRE

    Świeszczak, Krzysztof

    2016-01-01

    Skłonność społeczeństwa do prowadzenia własnej działalności gospodarczej odgrywa istotną rolę w rozwoju krajowych gospodarek. Biorąc pod uwagę charakterystykę jednostek należących do sektora MSP, ich potrzeby oraz bariery, niekiedy uniemożliwiające egzystencję na rynku, warto zwrócić uwagę na konieczność kreowania narzędzi wspomagających przedsiębiorczość. Spośród licznych instrumentów wsparcia jednostek z sektora MSP na szczególną uwagę zasługują inkubatory przedsiębiorczości , których dział...

  18. Cluster expansion of the wavefunction. Calculation of electron correlations in ground and excited states by SAC and SAC CI theories

    International Nuclear Information System (INIS)

    Nakatsuji, H.

    1979-01-01

    The SAC and SAC CI theories are formulated for actual calculations of singlet ground states and their excited states of arbitrary spin multiplicity. Approximations are considered for the variational methods since time-consuming terms are involved. The results of test calculations for singlet states have shown, with much smaller numbers of variables (sizes of the matrices involved), excellent agreement with the full CI and close-to-full CI results. This shows the utility of the SAC theory for ground states and especially of the SAC CI theory for excited states, since the slow convergence of the CI theory is much more critical for excited states than for ground states. (Auth.)

  19. Natureza e ciências sociais

    Directory of Open Access Journals (Sweden)

    Gloria Maria Vargas

    2003-12-01

    Full Text Available A construção do sentido do termo natureza abrange diferentes áreas do conhecimento e tem sido objeto de reflexão tanto das ciências naturais quanto sociais. Nos desdobramentos do conhecimento produzido sobre esta temática existem diversas abordagens que, da perspectiva das ciências sociais, podem ser identificadas. O propósito deste artigo é considerar algumas dessas abordagens e relacioná-las com as novas práticas sociais que determinam formas de intervenção inéditas sobre a natureza, e que colocam questões para estas ciências, enquanto produtoras de conhecimento sobre o tema. De igual forma, explicita-se a substituição deste termo pelo de ambiente e, posteriormente, o aparecimento do desenvolvimento sustentável, como parte do cabedal conceitual com que a problemática em torno das relações naturezasociedade é abordada nas ciências sociais.La construcción del sentido del término naturaleza abarca diferentes áreas del conocimiento y ha sido objeto de reflexión tanto de las ciencias naturales como sociales. Los desdoblamientos del conocimiento producido sobre este tema muestran que existen diversos abordajes que pueden ser identificados desde la perspectiva de las ciencias sociales. El objetivo de este artículo es considerar algunos de esos abordajes y relacionarlos con las nuevas prácticas sociales que determinan formas de intervención inéditas sobre la naturaleza y que sugieren cuestionamientos para estas ciencias, como productoras de conocimiento sobre este tema. De igual manera, se explicita la substitución de este término por el de ambiente e, posteriormente, el aparecimiento del término desarrollo sostenible como parte del acervo conceptual con que es abordada la problemática alrededor de las relaciones naturaleza-sociedad en las ciencias sociales.The construction of the term nature involves different areas of knowledge and has been the object of inquiry of both natural and social sciences. The knowledge

  20. Oxidation of SO2 by stabilized Criegee intermediate (sCI radicals as a crucial source for atmospheric sulfuric acid concentrations

    Directory of Open Access Journals (Sweden)

    M. Boy

    2013-04-01

    Full Text Available The effect of increased reaction rates of stabilized Criegee intermediates (sCIs with SO2 to produce sulfuric acid is investigated using data from two different locations, SMEAR II, Hyytiälä, Finland, and Hohenpeissenberg, Germany. Results from MALTE, a zero-dimensional model, show that using previous values for the rate coefficients of sCI + SO2, the model underestimates gas phase H2SO4 by up to a factor of two when compared to measurements. Using the rate coefficients recently calculated by Mauldin et al. (2012 increases sulfuric acid by 30–40%. Increasing the rate coefficient for formaldehyde oxide (CH2OO with SO2 according to the values recommended by Welz et al. (2012 increases the H2SO4 yield by 3–6%. Taken together, these increases lead to the conclusion that, depending on their concentrations, the reaction of stabilized Criegee intermediates with SO2 could contribute as much as 33–46% to atmospheric sulfuric acid gas phase concentrations at ground level. Using the SMEAR II data, results from SOSA, a one-dimensional model, show that the contribution from sCI reactions to sulfuric acid production is most important in the canopy, where the concentrations of organic compounds are the highest, but can have significant effects on sulfuric acid concentrations up to 100 m. The recent findings that the reaction of sCI + SO2 is much faster than previously thought together with these results show that the inclusion of this new oxidation mechanism could be crucial in regional as well as global models.

  1. sobre la calidad del agua de la ciénaga

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Chalarca Rodríguez

    2007-01-01

    Full Text Available En el municipio de Ayapel, departamento de Córdoba, se realizaron cuatro muestreos de campo con el fin de obtener información representativa de las variaciones horarias del agua residual del municipio como también de la calidad del agua en la zona de influencia de éstas en la ciénaga de Ayapel. En el sector donde se presentan las principales descargas del alcantarillado se determinaron las variables fisicoquímicas y microbiológicas del agua residual doméstica y de la ciénaga. Ello con el fin de determinar el posible impacto de las aguas residuales domésticas sobre la calidad del agua de un sector de la ciénaga de Ayapel.Los resultados del estudio permiten afirmar que existe un impacto de las aguas residuales sobre el complejo cenagoso, sin embargo estas descargas afectan principalmente la calidad ambiental de los sitios aledaños al casco urbano del municipio de Ayapel, principalmente en las épocas de aguas bajas incluyendo la zona pelágica del sector E0.

  2. Wpływ regularnej aktywności fizycznej na skład ciała i ciśnienie tętnicze dzieci ze szkoły sportowej

    Directory of Open Access Journals (Sweden)

    Małgorzata Stańczyk

    2013-06-01

    Full Text Available Wstęp: Trening fizyczny uważany jest za czynnik wpływający na parametry antropometryczne i ciśnienie tęt‑ nicze. Twierdzi się, że osoby regularnie ćwiczące mają lepsze wskaźniki składu ciała oraz niższe wartości ciśnienia tętniczego krwi w porównaniu z osobami nieuprawiającymi sportu. Cel: Ocena wpływu regularnej rocznej aktywności fizycznej prowadzonej w szkole sportowej na skład ciała oraz wartości ciśnienia tętnicze‑ go u dzieci 14-letnich (II klasa gimnazjum. Materiał i metodyka: W badaniu wzięło udział 25 dzieci z gim‑ nazjum sportowego. Dzieci badano dwukrotnie w odstępie 12 miesięcy. Analizie poddano zmianę parame‑ trów antropometrycznych, składu ciała metodą impedancji bioelektrycznej oraz wartości ciśnienia krwi. Wyniki: W całej grupie zaobserwowano wzrost wartości centylowych ciśnienia skurczowego krwi (p < 0,05, przede wszystkim u chłopców. W zakresie ciśnienia rozkurczowego nie zanotowano istotnych różnic. Skład ciała zmienił się niekorzystnie u wszystkich badanych – wzrósł udział tłuszczu (13% vs 20%, p < 0,05, a przy‑ rost masy tłuszczowej był wyższy u dziewczynek (6% vs 3%, p < 0,05. Centyl BMI istotnie statystycznie wzrósł w grupie dziewczynek (37 vs 49, p < 0,05, u chłopców nie uległ zmianie. Wnioski: Aktywność fizyczna proponowana przez szkołę sportową nie poprawia stanu odżywienia 13–14-letnich dziewcząt i chłopców, u których obserwuje się istotne zwiększenie w organizmie zawartości tkanki tłuszczowej. Szkolna aktywność fizyczna nie powoduje obniżenia ciśnienia tętniczego wśród młodzieży w wieku 13–14 lat w odniesieniu do norm wiekowych. W zakresie ciśnienia skurczowego w grupie chłopców zaobserwowano nawet wyższe wartości centylowe.

  3. Transseksualizm – pytania i wątpliwości

    Directory of Open Access Journals (Sweden)

    Magdalena Radko

    2012-06-01

    Full Text Available Wiek dojrzewania jest czasem określania własnej tożsamości, odkrywania pragnień, dążeń, również w sferze sek‑ sualności. Poszukiwanie siebie, własnej orientacji seksualnej, znajdowanie pierwszych obiektów pożądania jest dla adolescenta nowym, ważnym przeżyciem, wyzwalającym silne emocje. Czasami jednak młody człowiek staje wo‑ bec dużych trudności, bowiem to, co odkrywa w sobie, nie znajduje umocowania w społecznych normach, nie jest akceptowane przez rodzinę i otoczenie, a w związku z tym dla samego adolescenta staje się ciężarem trudnym do uniesienia. Konsekwencją nieradzenia sobie z własną seksualnością, jej odbiorem rodzinnym lub społecznym mogą być zaburzenia depresyjne, lękowe, zaburzenia odżywiania oraz różnorodne formy autoagresji. W obliczu wysokie‑ go ryzyka występowania zaburzeń psychicznych u osób w wieku rozwojowym, u których seksualność kształtuje się w sposób odmienny, należy rozważać szerokie spektrum czynników mogących determinować takie, a nie inne oblicze seksualności. Intencją autorów pracy było przedstawienie, w oparciu o przypadek kliniczny, historii człowieka odkry‑ wającego swoją tożsamość płciową, biorąc pod uwagę zarówno osobnicze uwarunkowania, przebyte zdarzenia trau‑ matyczne, jak i kontekst rodzinny pacjenta oraz konsekwencje procesu coming out. Autorzy starali się zwrócić uwagę na złożoność i wielostopniowość procesu ujawniania się, który stał się możliwy dopiero po zapewnieniu adolescen‑ towi zrozumienia, wsparcia i akceptacji. Tym samym ukazano kluczową rolę środowiska, które może sprzyjać pro‑ cesowi odkrywania się i umożliwić go lub przeciwnie – utrudnić czy też całkowicie go zablokować. Transseksualizm w różnych środowiskach budzi sporo kontrowersji, pytań i wątpliwości. Historia hospitalizowanego pacjenta obrazu‑ je złożoność problemów, z którymi zmagają się osoby z zaburzeniami tożsamości

  4. FUNKCJA SUM HARMONICZNYCH W SKRÓCONEJ PROCEDURZE OZNACZANIA ZESPOLONEGO MODUŁU SZTYWNOŚCI MMA

    Directory of Open Access Journals (Sweden)

    Andrzej POŻARYCKI

    2016-07-01

    Full Text Available W standardowej procedurze oznaczania sztywności mieszanek mineralno-asfalto-wych w funkcji częstotliwości obciążenia, powszechnie stosuje się metodę badań próbek obciążonych serią funkcji sinusoidalnych. W zależności od przyjętego wachlarza deklarowanych przez laboranta częstotliwości, procedura z serią badań stanowi procedurę inwazyjną, zwiększając jednocześnie prawdopodobieństwo wystąpienia zjawisk zmęczeniowych w badanych próbkach podczas realizowania testu. W pracy, w miejsce powszechnie stosowanej procedury zaproponowano obciążenie w formie funkcji utworzonej jako sumy funkcji harmonicznych. Na podstawie analizy wyników badań sztywności próbki belkowej wykazano, że proponowane podejście wyraźnie skraca czas procedury oznaczania zespolonego modułu sztywności, a różnice między standardowym ujęciem a tym proponowanym w pracy są w przeważającej większości mniejsze niż 2 %.

  5. Impact of previous virological treatment failures and adherence on the outcome of antiretroviral therapy in 2007.

    Directory of Open Access Journals (Sweden)

    Marie Ballif

    Full Text Available BACKGROUND: Combination antiretroviral treatment (cART has been very successful, especially among selected patients in clinical trials. The aim of this study was to describe outcomes of cART on the population level in a large national cohort. METHODS: Characteristics of participants of the Swiss HIV Cohort Study on stable cART at two semiannual visits in 2007 were analyzed with respect to era of treatment initiation, number of previous virologically failed regimens and self reported adherence. Starting ART in the mono/dual era before HIV-1 RNA assays became available was counted as one failed regimen. Logistic regression was used to identify risk factors for virological failure between the two consecutive visits. RESULTS: Of 4541 patients 31.2% and 68.8% had initiated therapy in the mono/dual and cART era, respectively, and been on treatment for a median of 11.7 vs. 5.7 years. At visit 1 in 2007, the mean number of previous failed regimens was 3.2 vs. 0.5 and the viral load was undetectable (4 previous failures compared to 1 were 0.9 (95% CI 0.4-1.7, 0.8 (0.4-1.6, 1.6 (0.8-3.2, 3.3 (1.7-6.6 respectively, and 2.3 (1.1-4.8 for >2 missed cART doses during the last month, compared to perfect adherence. From the cART era, odds ratios with a history of 1, 2 and >2 previous failures compared to none were 1.8 (95% CI 1.3-2.5, 2.8 (1.7-4.5 and 7.8 (4.5-13.5, respectively, and 2.8 (1.6-4.8 for >2 missed cART doses during the last month, compared to perfect adherence. CONCLUSIONS: A higher number of previous virologically failed regimens, and imperfect adherence to therapy were independent predictors of imminent virological failure.

  6. Empiryczna weryfikacja hipotezy o przenośności modelu Altmana na warunki polskiej gospodarki oraz uniwersalności sektorowej modeli

    Directory of Open Access Journals (Sweden)

    Tomasz Iwanowicz

    2018-03-01

    Full Text Available Celem artykułu jest próba udzielenia odpowiedzi na pytanie, czy istnieje uzasadnienie dla mechanicznego przenoszenia modelu Altmana na warunki polskiej gospodarki oraz sprawdzenie, czy wśród testowanych modeli istnieje model wykazujący dla każdego typu przedsiębiorstwa (przemysłowe, handlowe, usługo- we najwyższą skuteczność i najlepsze wartości zastosowanych metod porównawczych. W artykule porównano trzynaście testowanych modeli używając macierzy klasyfikacji, ilorazu szans, krzywej kon- centracji CAP i wskaźnika dokładności Giniego, będących metodami oceny sprawności, oraz wskaźnika Briera będącego metodą oceny modeli z punktu widzenia kryterium kalibracji. Badania zostały przepro- wadzone na bazie 439 sprawozdań finansowych opublikowanych przez 139 spółek kapitałowych zarejestrowanych w warszawskich sądach okręgowych i rejonowych (w tym 79 spółek, które w rzeczywistości ogłosiły upadłość. Przeprowadzone badania obaliły mit o przenośności modelu Altmana na warunki polskiej gospodarki oraz uniwersalności sektorowej modeli. Wykazano, że sprawność modeli różni się dla spółek produkcyjnych, handlowych i usługowych oraz określono te sprawności. Ponadto udowodniono, że istnieją modele dyskryminacyjne różniące się zestawem zmiennych oraz współczynnikami wagowymi, które wykazują zbliżone skuteczności predykcyjne. The purpose of this paper is to answer the question about the validity of mechanical transfer of the Alt- man model to Polish economy and to check if among the tested models there is a model with the highest efficiency and best outcomes for the used comparative methods for each type of enterprise (manufactur- ing, trading, service. Thirteen tested models were compared using the classification matrix, odds ratio, CAP concentration curve and Gini accuracy index, which are efficiency evaluation methods, as well as using the Brier index, which is a method of evaluating models

  7. Filosofia das ciências sociais: temas atuais

    OpenAIRE

    Kincaid, Harold

    2014-01-01

    A filosofia das ciências sociais, concebida da maneira adequada, tem algo a oferecer aos que praticam as ciências sociais. Os cientistas sociais adotam em suas pesquisas, ainda que de forma implícita, alguma filosofia de sua ciência. Para evitar impasses, é melhor explicitar essa filosofia e ser criticamente consciente dos seus méritos. A filosofia das ciências sociais, por sua vez, não pode ser praticada sem um envolvimento íntimo com a pesquisa social. O artigo esboça alguns desenvolvimento...

  8. Farmakogenetyczne uwarunkowania lekooporności w padaczce

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    Alicja Kozera-Kępniak

    2013-06-01

    Full Text Available Padaczka jest jedną z najczęstszych chorób ośrodkowego układu nerwowego, występującą u około 1% populacji na świecie. Charakteryzuje się występowaniem nawracających napadów o różnej symptomatologii. Szacuje się, że u 30% pacjentów mimo prowadzonego właściwego leczenia przeciwpadaczkowego nadal występują napady drgawkowe. Jest to tak zwane zjawisko lekooporności. W Polsce problem ten dotyczy około 100 000–120 000 chorych. Czynnikami predysponującymi do wystąpienia padaczki lekoopornej są: ujawnienie się choroby przed 1. rokiem życia, duża częstotliwość napadów przed rozpoczęciem leczenia oraz zmiany strukturalne mózgu, w tym wady rozwojowe kory mózgowej. Niekontrolowane napady padaczkowe pogarszają jakość życia chorych, zwiększając ryzyko urazów, wpływając negatywnie na samopoczucie fizyczne oraz funkcjonowanie psychospołeczne. Chociaż znane są potencjalne czynniki ryzyka, to nadal nie wiadomo, dlaczego u dwóch pacjentów z tym samym rodzajem padaczki lub tym samym typem napadów skuteczność leczenia lekami przeciwpadaczkowymi może być skrajnie różna. Wśród możliwych przyczyn tego zjawiska wymienia się czynniki genetyczne, zmieniające właściwości farmakodynamiczne i farmakokinetyczne stosowanych leków. Do grupy tych czynników zalicza się: genetycznie uwarunkowany polimorfizm niektórych enzymów mikrosomalnych (CYP2C9, CYP2C19, glikoproteiny P, białka MRP (multidrug resistance-associated protein oraz zaburzenia funkcji farmakodynamicznych receptorów GABA (GABAA i kana- łów jonowych. Wydaje się, że badania nad mechanizmami lekooporności mogą skutkować wprowadzeniem nowych strategii terapeutycznych. Niniejszy artykuł ma na celu przedstawienie wpływu powyżej wymienionych czynników genetycznych na brak skuteczności leczenia w padaczce.

  9. Regulation of notochord-specific expression of Ci-Bra downstream genes in Ciona intestinalis embryos.

    Science.gov (United States)

    Takahashi, Hiroki; Hotta, Kohji; Takagi, Chiyo; Ueno, Naoto; Satoh, Nori; Shoguchi, Eiichi

    2010-02-01

    Brachyury, a T-box transcription factor, is expressed in ascidian embryos exclusively in primordial notochord cells and plays a pivotal role in differentiation of notochord cells. Previously, we identified approximately 450 genes downstream of Ciona intestinalis Brachyury (Ci-Bra), and characterized the expression profiles of 45 of these in differentiating notochord cells. In this study, we looked for cisregulatory sequences in minimal enhancers of 20 Ci-Bra downstream genes by electroporating region within approximately 3 kb upstream of each gene fused with lacZ. Eight of the 20 reporters were expressed in notochord cells. The minimal enchancer for each of these eight genes was narrowed to a region approximately 0.5-1.0-kb long. We also explored the genome-wide and coordinate regulation of 43 Ci-Bra-downstream genes. When we determined their chromosomal localization, it became evident that they are not clustered in a given region of the genome, but rather distributed evenly over 13 of the 14 pairs of chromosomes, suggesting that gene clustering does not contribute to coordinate control of the Ci-Bra downstream gene expression. Our results might provide Insights Into the molecular mechanisms underlying notochord formation in chordates.

  10. A inclusão na perspectiva do novo paradigma da ciência

    Directory of Open Access Journals (Sweden)

    Reinoldo Marqueza

    2011-12-01

    Full Text Available O estudo aborda o processo de transição paradigmática da ciência moderna para a ciência pós-moderna. Salienta as características do paradigma atual, a crise desse paradigma e aponta os contornos do paradigma emergente na perspectiva do sociólogo Boaventura Sousa Santos. Refere a Educação Inclusiva como um novo processo de produção e de apropriação do conhecimento e como uma nova forma de estar na relação.Palavras-chave: Paradigma. Conhecimento. Educação Inclusiva.

  11. Ocena Nośności Konstrukcji Nawierzchni Lotniskowych Metodą Acn-Pcn

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    Wesołowski Mariusz

    2014-12-01

    Full Text Available Konstrukcje nawierzchni lotniskowych są projektowane na określony okres eksploatacji przy założeniu prognozowanego natężenia i struktury ruchu lotniczego. Bezpieczeństwo wykonywania operacji lotniczych przez statki powietrzne na nawierzchniach lotniskowych zależy przede wszystkim od stanu nośności ich konstrukcji. W związku z tym, kontrolne badania nośności należy przeprowadzać okresowo, gdyż informacja o aktualnym stanie eksploatacyjnym nawierzchni lotniskowej stanowi podstawę do podejmowania decyzji o rodzajach statków powietrznych dopuszczonych do ruchu, intensywności ruchu lotniczego oraz terminach rozpoczęcia prac remontowych lub modernizacyjnych. Aktualnie do oceny nośności nawierzchni lotniskowych stosuje się metodę ACN-PCN, która została wprowadzona przez Organizację Międzynarodowego Lotnictwa Cywilnego ICAO (International Civil Aviation Organization. W artykule przedstawiony został sposób wyznaczania i opisu wskaźnika PCN

  12. Geochemistry of CI chondrites: Major and trace elements, and Cu and Zn Isotopes

    Science.gov (United States)

    Barrat, J. A.; Zanda, B.; Moynier, F.; Bollinger, C.; Liorzou, C.; Bayon, G.

    2012-04-01

    In order to check the heterogeneity of the CI chondrites and determine the average composition of this group of meteorites, we analyzed a series of six large chips (weighing between 0.6 and 1.2 g) of Orgueil prepared from five different stones. In addition, one sample from each of Ivuna and Alais was analyzed. Although the sizes of the chips used in this study were “large”, our results show evidence for minor chemical heterogeneity in Orgueil, particularly for alkali elements and U. After removal of one outlier sample, the spread of the results is considerably reduced. For most of the 46 elements analyzed in this study, the average composition calculated for Orgueil is in very good agreement with previous CI estimates. This average, obtained with a “large” mass of samples, is analytically homogeneous and is suitable for normalization purposes. Finally, the Cu and Zn isotopic ratios are homogeneously distributed within the CI parent body with a spread of less than 100 ppm per atomic mass unit (amu).

  13. Sprawozdawczość zintegrowana jako nowy obszar badań naukowych w rachunkowości

    Directory of Open Access Journals (Sweden)

    Joanna Krasodomska

    2015-06-01

    Full Text Available Celem artykułu jest przedstawienie sprawozdawczości zintegrowanej jako interesującego, nowego obszaru badań naukowych w rachunkowości. Zakłada ona publikację raportu prezentującego, jak przyjęte przez przedsiębiorstwo strategia, zasady zarządzania, wyniki działalności i perspektywy rozwoju prowadzą do tworzenia wartości. W artykule omówiono stanowiące podstawę sprawozdawczości zintegrowanej koncepcje modelu biznesu oraz sześciu kapitałów. Na podstawie dokonanego przeglądu literatury przedstawiono kierunki badań z zakresu sprawozdawczości zintegrowanej, prezentowane w artykułach naukowych indeksowanych w bazach EBSCO i Emerald oraz postulowane przez Międzynarodową Radę ds. Zintegrowanej Sprawozdawczości (International Integrated Reporting Council – IIRC we współpracy ze Stowarzyszeniem Dyplomowanych Biegłych Księgowych (Association of Chartered Certified Accountants – ACCA i Międzynarodowym Stowarzyszeniem Edukacji Rachunkowości i Badań (International Association for Accounting Education & Research – IAAER. Wskazano też tematy opracowań podejmujących ten problem, przyjętych do prezentacji na Kongresie Europejskiego Stowarzyszenia Rachunkowości (European Accounting Association – EAA w Glasgow w kwietniu 2015 r. Analizą objęto również dorobek polskich autorów podejmujących w swoich badaniach problematykę sprawozdawczości zintegrowanej. Przegląd literatury dotyczącej sprawozdawczości zintegrowanej oraz obecnie prowadzonych badań pozwolił na zidentyfikowanie luk badawczych i wskazanie problemów wartych naukowych dociekań. Zaliczono do nich m.in. zagadnienia związane z modelem biznesu, koncepcją wartości, sześcioma kapitałami, jakością i istotnością raportów zintegrowanych, zaspokajaniem przez raporty zintegrowane potrzeb informacyjnych użytkowników oraz rolą księgowych i biegłych rewidentów w opracowywaniu i weryfikacji sprawozdawczości zintegrowanej. 

  14. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform

    Science.gov (United States)

    Moutsatsos, Ioannis K.; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J.; Jenkins, Jeremy L.; Holway, Nicholas; Tallarico, John; Parker, Christian N.

    2016-01-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an “off-the-shelf,” open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community. PMID:27899692

  15. Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform.

    Science.gov (United States)

    Moutsatsos, Ioannis K; Hossain, Imtiaz; Agarinis, Claudia; Harbinski, Fred; Abraham, Yann; Dobler, Luc; Zhang, Xian; Wilson, Christopher J; Jenkins, Jeremy L; Holway, Nicholas; Tallarico, John; Parker, Christian N

    2017-03-01

    High-throughput screening generates large volumes of heterogeneous data that require a diverse set of computational tools for management, processing, and analysis. Building integrated, scalable, and robust computational workflows for such applications is challenging but highly valuable. Scientific data integration and pipelining facilitate standardized data processing, collaboration, and reuse of best practices. We describe how Jenkins-CI, an "off-the-shelf," open-source, continuous integration system, is used to build pipelines for processing images and associated data from high-content screening (HCS). Jenkins-CI provides numerous plugins for standard compute tasks, and its design allows the quick integration of external scientific applications. Using Jenkins-CI, we integrated CellProfiler, an open-source image-processing platform, with various HCS utilities and a high-performance Linux cluster. The platform is web-accessible, facilitates access and sharing of high-performance compute resources, and automates previously cumbersome data and image-processing tasks. Imaging pipelines developed using the desktop CellProfiler client can be managed and shared through a centralized Jenkins-CI repository. Pipelines and managed data are annotated to facilitate collaboration and reuse. Limitations with Jenkins-CI (primarily around the user interface) were addressed through the selection of helper plugins from the Jenkins-CI community.

  16. ANALIZA MOŻLIWOŚCI ZASTOSOWANIA ODPADOWEGO PYŁU BAZALTOWEGO W ZAPRAWIE CEMENTOWEJ

    Directory of Open Access Journals (Sweden)

    Magdalena DOBISZEWSKA

    2016-07-01

    Full Text Available Rosnące zapotrzebowanie na surowce naturalne do produkcji materiałów budowlanych, spowodowało intensyfikację badań dotyczących możliwości wykorzystania w produkcji budowlanej materiałów odpadowych. Powszechnie, jako dodatek mineralny do cementu stosowany jest granulowany żużel wielkopiecowy, popiół lotny, czy też pył krzemionkowy. Podczas obróbki kruszywa stosowanego do produkcji mas mineralno-asfaltowych (MMA powstają duże ilości odpadów pylastych. Utylizacja tych odpadów stanowi obecnie duży problem w wielu wytwórniach MMA. W pracy dokonano analizy możliwości zastosowania odpadowego pyłu bazaltowego do produkcji zaprawy cementowej. Najpierw zbadano właściwości fizyczne i chemiczne zastosowanego pyłu bazaltowego. Celem określenia wpływu dodatku pyłu bazaltowego na niektóre właściwości zapraw przygotowano cztery mieszanki, w których pył bazaltowy stanowił częściowy zamiennik piasku w ilości 0-30% masy piasku. Badania doświadczalne dotyczyły analizy wpływu pyłu na wytrzymałość zapraw na ściskanie i zginanie po 2, 28 i 56 dniach dojrzewania próbek, mrozoodporności, nasiąkliwość oraz zdolności do kapilarnego podciągania wody. Następnie przeprowadzono badania dotyczące wpływu dodatku pyłu bazaltowego na mikrostrukturę oraz porowatość zaprawy. Wyniki przeprowadzonych badań wskazują na to, że pył bazaltowy może być stosowany do produkcji zapraw cementowych, jako substytut piasku naturalnego. Zastąpienie części piasku w zaprawie cementowej przez pył bazaltowy pozwoli na zagospodarowanie odpadu przemysłowego oraz wpłynie na poprawę niektórych cech zaprawy cementowej.

  17. Część I – ocena okoliczności i biomechaniki urazu

    Directory of Open Access Journals (Sweden)

    Grzegorz Teresiński

    2014-10-01

    Full Text Available Badania nad etiologią i zapobieganiem dystorsji kręgosłupa szyjnego pozostają od wielu lat w centrum zainteresowania badaczy związanych z przemysłem samochodowym i medycyną wypadkową, a także towarzystw ubezpieczeniowych. Etiopatogeneza zespołu dolegliwości związanych z tzw. whiplash (WAD budzi wciąż kontrowersje i jak dotychczas nie udało się w jednoznaczny sposób ustalić jego morfologicznych wykładników. Subiektywny charakter skarg powoduje bardzo duże trudności w obiektywizacji następstw urazu akceleracyjno- deceleracyjnego oraz weryfikacji zgłaszanych roszczeń. Celem pracy było przedstawienie  zależności biomechanicznych oraz okoliczności towarzyszących powstawaniu WAD wynikających z badań populacyjnych, statystyk firm ubezpieczeniowych oraz analizy zapisów rejestratorów zderzeń montowanych przez producentów samochodów. Znajomość technicznych aspektów okoliczności powstawania WAD może ułatwić medyczną ocenę tego rodzaju następstw.

  18. Risks of cardiovascular adverse events and death in patients with previous stroke undergoing emergency noncardiac, nonintracranial surgery

    DEFF Research Database (Denmark)

    Christiansen, Mia N.; Andersson, Charlotte; Gislason, Gunnar H.

    2017-01-01

    Background: The outcomes of emergent noncardiac, nonintracranial surgery in patients with previous stroke remain unknown. Methods: All emergency surgeries performed in Denmark (2005 to 2011) were analyzed according to time elapsed between previous ischemic stroke and surgery. The risks of 30-day...... mortality and major adverse cardiovascular events were estimated as odds ratios (ORs) and 95% CIs using adjusted logistic regression models in a priori defined groups (reference was no previous stroke). In patients undergoing surgery immediately (within 1 to 3 days) or early after stroke (within 4 to 14...... and general anesthesia less frequent in patients with previous stroke (all P Risks of major adverse cardiovascular events and mortality were high for patients with stroke less than 3 months (20.7 and 16.4% events; OR = 4.71 [95% CI, 4.18 to 5.32] and 1.65 [95% CI, 1.45 to 1.88]), and remained...

  19. Prevalent musculoskeletal pain as a correlate of previous exposure to torture

    DEFF Research Database (Denmark)

    Olsen, Dorte Reff; Montgomery, Edith; Bojholm, S

    2006-01-01

    AIM: To research possible associations between previous exposure to specific torture techniques and prevalent pain in the head and face, back, and feet. METHODS: 221 refugees, 193 males and 28 females, previously exposed to torture in their home country, were subject to a clinical interview...... was general abuse of the whole body (OR 5.64, 95% CI 1.93-16.45). CONCLUSION: In spite of many factors being potentially co-responsible for prevalent pain, years after the torture took place it presents itself as strongly associated with specific loci of pain, with generalized effects, and with somatizing....

  20. Gefitinib Plus Interleukin-2 in Advanced Non-Small Cell Lung Cancer Patients Previously Treated with Chemotherapy

    Directory of Open Access Journals (Sweden)

    Melissa Bersanelli

    2014-09-01

    Full Text Available The activation of lymphocytes by gefitinib treatment has been described. In this phase II pilot trial, we explored the possible synergism between IL-2 and gefitinib for non-small cell lung cancer (NSCLC treatment. From September, 2003, to November, 2006, 70 consecutive patients with advanced, progressive NSCLC, previously treated with chemotherapy, received oral gefitinib 250 mg daily. The first 39 patients received gefitinib alone (G group. The other 31 also received subcutaneous IL-2 (GIL-2 group: 1 MIU/m2 (Million International Unit/m2twice a day on Days 1 and 2, once a day on Days 3, 4, 5 every week for four consecutive weeks with a four-week rest period. Median follow-up was 25.2 months. Grade 3–4 toxicity of gefitinib was represented by skin rash (7%, asthenia/anorexia (6% and diarrhea (7%; patients treated with IL-2 showed grade 2–3 fever (46%, fatigue (21% and arthralgia (13%. In the GIL-2 group and G-group, we respectively observed: an overall response rate of 16.1% (6.4% complete response and 5.1% (only partial response; a disease control rate of 41.9% and 41%; a median time to progression of 3.5 (CI 95% = 3.2–3.8 and 4.1 (CI 95% = 2.6–5.7 months; a median overall survival of 20.1 (CI 95% = 5.1–35.1 and 6.9 (CI 95% = 4.9–8.9 months (p = 0.002; and an actuarial one-year survival rate of 54% and 30%. Skin toxicity (p < 0.001; HR = 0.29; CI 95% = 0.16–0.54 and use of IL-2 (p < 0.001; HR = 0.33; CI 95% = 0.18–0.60 were independently associated with improvement of survival. In this consecutive, non-randomized, series of advanced NSCLC patients, the use of IL-2 increased the efficacy of gefitinib.

  1. Seria a Metafísica Essencial à Ciência e ao Senso Comum?

    Directory of Open Access Journals (Sweden)

    Rafael Sandoval

    2017-02-01

    Full Text Available Uma das declarações mais consensuais da História da Filosofia é a que diz que a Metafísica não é ciência, mas pensamento. Neste artigo, procurar-se-á defender a tese que a Metafísica é condição para o senso comum e a ciência. Primeiro, é mostrado que os termos ao qual nós utilizamos diariamente refletem nossa imagem de mundo. Quando pensamos e fazemos previsões, fazemos o uso espontâneo de termos com significado universal. Depois, é procurado evidenciar que a ciência naturalmente faz uso de termos com significado universal quando faz previsões. Finalmente, buscará apresentar que a Metafísica é anterior às nossas hipóteses e especulações.

  2. O ensino de conteúdos de História e Filosofia da Ciência

    Directory of Open Access Journals (Sweden)

    Fernando Bastos

    1998-01-01

    Full Text Available O presente trabalho de pesquisa consistiu em duas etapas: (i produção de um Guia de Estudos em que a história das pesquisas sobre a febre amarela (1881-1903 foi usada como subsídio para a discussão de alguns importantes aspectos do processo de produção de conhecimentos na ciência; (ii realização de experiência pedagógica em que o Guia de Estudos foi aplicado junto a alunos do ensino médio. Os resultados obtidos forneceram evidência da viabilidade do uso da História da Ciência no Ensino de Ciências.

  3. Destruction of post-surgery thyroid remnants by 19 mCi (703 MBq) of iodine 131

    International Nuclear Information System (INIS)

    Tassy, D.; Lonchampt, M.F.; Minebois, A.; Antigny, J.F.

    1997-01-01

    The adjuvant treatment by iodine 131 in good prognostic forms of differentiated thyroid cancers (DTC) makes not the object of a general consensus. There is no study demonstrating the benefit from such a treatment. Administration of an elevated iodine 131 activity and the constraint of a supplementary hospitalization are in these conditions questionable. In 6 patients, presenting the criteria of good prognostic and in post-operation, ambulatory conditions, administration of 19 mCi (703 MBc) of iodine 131 was done without previous administration of tracing dosage, followed after 72 hours by a whole-body scintigraphy, in the usual pause conditions. This administration was repeated 6 to 12 months later and followed by a new scintigraphic examination. The cervical fixation of iodine 131 was established qualitatively and quantitatively (as compared with a control zone). Five/six patients presented initially a cervical intense fixation with the star-like usual image and 1/6 patient a moderated fixation. Beginning with the second administration no cervical fixation was noted in 4/6 patients and a very low fixation in 2/6 patients. The concomitantly measured thyroglobulin, under simulation by TSH endogenous, was 131 I after quasi-total thyroidectomy in good-prognostic forms of DTC, without administration of previous tracing dosage to avoid possible phenomena of thyroid tissue blocking, allows probably, in overwhelming majority of cases, both a full or quasi-full destruction of the thyroid remnants and a severe reduction in the thyroglobulin rate measured in the conditions of pause of hormone-therapy

  4. CI+MBPT calculations of Ar I energies, g factors, and transition line strengths

    Science.gov (United States)

    Savukov, I. M.

    2018-03-01

    Excited states of noble gas atoms present certain challenges to atomic theory for several reasons: first, relativistic effects are important and LS coupling is not optimal; second, energy intervals can be quite small, leading to strong mixing of states; third, many-body perturbation theory for hole states does not converge well. Previously, some attempts were made to solve this problem, using for example the all-order coupled-cluster approach and particle-hole configuration-interaction many-body perturbation theory (CI-MBPT) with modified denominators. However, while these approaches were promising, the accuracy was still limited. In this paper, we calculate Ar I energies, g factors, and transition amplitudes using ab initio CI-MBPT with eight valence electrons to avoid the problem of slow convergence of MBPT due to strong interaction between 3p and 3s states. We also included in CI many dominant states obtained by double excitations of the ground state configuration. Thus perturbation corrections were needed only for 1s, 2s, 2p core electrons non-included in valence-valence CI, which are quite small. We found that energy, g factors, and electric dipole matrix elements are in reasonable agreement with experiments. It is noteworthy that the theory agreed well with accurately measured g factors. Experimental oscillator strengths have large uncertainty, so in some cases we made a comparison with average values.

  5. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    International Nuclear Information System (INIS)

    Abulí, Anna; Morillas, Juan D; Rigau, Joaquim; Latorre, Mercedes; Fernández-Bañares, Fernando; Peña, Elena; Riestra, Sabino; Payá, Artemio; Jover, Rodrigo; Xicola, Rosa M; Llor, Xavier; Fernández-Rozadilla, Ceres; Carvajal-Carmona, Luis; Villanueva, Cristina M; Moreno, Victor; Piqué, Josep M; Carracedo, Angel; Castells, Antoni; Andreu, Montserrat; Ruiz-Ponte, Clara; Castellví-Bel, Sergi; Alonso-Espinaco, Virginia; Muñoz, Jenifer; Gonzalo, Victoria; Bessa, Xavier; González, Dolors; Clofent, Joan; Cubiella, Joaquin

    2011-01-01

    Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1 [rs698 in ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive), rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive), rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant), and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1

  6. Previous experience of family violence and intimate partner violence in pregnancy.

    Science.gov (United States)

    Ludermir, Ana Bernarda; Araújo, Thália Velho Barreto de; Valongueiro, Sandra Alves; Muniz, Maria Luísa Corrêa; Silva, Elisabete Pereira

    2017-01-01

    To estimate differential associations between the exposure to violence in the family of origin and victimization and perpetration of intimate partner violence in pregnancy. A nested case-control study was carried out within a cohort study with 1,120 pregnant women aged 18-49 years old, who were registered in the Family Health Strategy of the city of Recife, State of Pernambuco, Brazil, between 2005 and 2006. The cases were the 233 women who reported intimate partner violence in pregnancy and the controls were the 499 women who did not report it. Partner violence in pregnancy and previous experiences of violence committed by parents or other family members were assessed with a standardized questionnaire. Multivariate logistic regression analyses were modeled to identify differential associations between the exposure to violence in the family of origin and victimization and perpetration of intimate partner violence in pregnancy. Having seen the mother suffer intimate partner violence was associated with physical violence in childhood (OR = 2.62; 95%CI 1.89-3.63) and in adolescence (OR = 1.47; 95%CI 1.01-2.13), sexual violence in childhood (OR = 3.28; 95%CI 1.68-6.38) and intimate partner violence during pregnancy (OR = 1.47; 95% CI 1.01 - 2.12). The intimate partner violence during pregnancy was frequent in women who reported more episodes of physical violence in childhood (OR = 2.08; 95%CI 1.43-3.02) and adolescence (OR = 1.63; 95%CI 1.07-2.47), who suffered sexual violence in childhood (OR = 3.92; 95%CI 1.86-8.27), and who perpetrated violence against the partner (OR = 8.67; 95%CI 4.57-16.45). Experiences of violence committed by parents or other family members emerge as strong risk factors for intimate partner violence in pregnancy. Identifying and understanding protective and risk factors for the emergence of intimate partner violence in pregnancy and its maintenance may help policymakers and health service managers to develop intervention strategies.

  7. Ciąża i poród u chorych na stwardnienie rozsiane

    Directory of Open Access Journals (Sweden)

    Małgorzata Czernichowska-Kotiuszko

    2014-04-01

    Full Text Available Stwardnienie rozsiane (łac. sclerosis multiplex, SM jest główną przyczyną niepełnosprawności u młodych dorosłych i jak większość chorób autoimmunologicznych częściej dotyczy kobiet. Wpływ ciąży na przebieg SM wzbudza zainteresowanie od wielu lat, a w ostatnim okresie stanowi temat badań wieloośrodkowych. Ciąża to zwykle okres bardzo dobrego samopoczucia chorych, najczęściej bez rzutów. Wynika to ze zmiany reaktywności immunologicznej na korzyść reakcji przeciwzapalnych związanych z limfocytami Th2 i cytokinami antyzapalnymi (interleukina 4, 5, 6, 10, TGF-β. Po porodzie zmienia się reaktywność immunologiczna i aktywność choroby wzrasta. Większość badań nie wykazała ogólnego negatywnego wpływu ciąży na niesprawność długoterminową związaną z SM; stwardnienie rozsiane nie ma negatywnego wpływu na przebieg ciąży, porodu i stan dziecka, dlatego chore kobiety mogą planować potomstwo. Choroba nie zwiększa ryzyka powikłań w ciąży i podczas porodu ani wad wrodzonych u dziecka w porównaniu z populacją ogólną. Jednakże każda terapia immunomodulująca jest przeciwwskazana w ciąży. Jeśli pacjentka decyduje się na dziecko, powinna przerwać leczenie; zaleca się również przerwę od leków przed zajściem w ciążę. W pracy podsumowano dostępne informacje na temat klinicznych problemów dotyczących ciąży i porodu u chorych na SM oraz oceniono zagrożenia dla dziecka związane z podawaniem leków.

  8. Double-balloon catheter for induction of labour in women with a previous cesarean section, could it be the best choice?

    Science.gov (United States)

    De Bonrostro Torralba, Carlos; Tejero Cabrejas, Eva Lucía; Marti Gamboa, Sabina; Lapresta Moros, María; Campillos Maza, Jose Manuel; Castán Mateo, Sergio

    2017-05-01

    We analysed the efficacy and safety of double-balloon catheter for cervical ripening in women with a previous cesarean section and which were the most important variables associated with an increased risk of repeated cesarean delivery. We designed an observational retrospective study of 418 women with unfavourable cervices (Bishop Score cesarean delivery, and induction of labour with a double-balloon catheter. Baseline maternal data and perinatal outcomes were recorded for a descriptive, bivariate, and multivariate analysis. A p value cesarean section were dystocia in the previous pregnancy (OR 1.744; CI 95% 1.066-2.846), the absence of previous vaginal delivery (OR 2.590; CI 95% 1.066-6.290), suspected fetal macrosomia (OR 2.410; CI 95% 0.959-6.054), and duration of oxytocin induction period (OR 1.005; CI 95% 1.004-1.006). The area under the curve was 0.789 (p cesarean delivery and unfavourable cervix. In our study, most women could have a vaginal delivery in spite of their risk factors for cesarean delivery. A multivariate model based on some clinical variables has moderate predictive value for intrapartum cesarean section.

  9. Prognozowanie i ujmowanie przychodóww przedsiębiorstwie postawionymw stan upadłości likwidacyjnej

    Directory of Open Access Journals (Sweden)

    Janusz Czerny

    2010-03-01

    Full Text Available W upadłości likwidacyjnej przedsiębiorstw mamy do czynienia z dwoma stru-mieniami przychodów, a mianowicie z przychodami dotyczącymi zbycia przedsię-biorstwa lub jego składników majątku oraz z przychodami związanymi z ewentual-nym kontynuowaniem działalności: Przychody ze sprzedaży przedsiębiorstwa powinny być prognozowane głównie na podstawie informacji płynących z systemu rachunkowości, co stanowi tzw. sta-tyczny aspekt upadłości, natomiast jej aspekt dynamiczny jest związany z zakre-sem i czasem kontynuowanej działalności, o czym decyduje syndyk, mając na uwa-dze naczelny cel upadłości, jakim jest optymalne zaspokojenie roszczeń wierzycieli.

  10. Combustion Stratification for Naphtha from CI Combustion to PPC

    KAUST Repository

    Vallinayagam, R.

    2017-03-28

    This study demonstrates the combustion stratification from conventional compression ignition (CI) combustion to partially premixed combustion (PPC). Experiments are performed in an optical CI engine at a speed of 1200 rpm for diesel and naphtha (RON = 46). The motored pressure at TDC is maintained at 35 bar and fuelMEP is kept constant at 5.1 bar to account for the difference in fuel properties between naphtha and diesel. Single injection strategy is employed and the fuel is injected at a pressure of 800 bar. Photron FASTCAM SA4 that captures in-cylinder combustion at the rate of 10000 frames per second is employed. The captured high speed video is processed to study the combustion homogeneity based on an algorithm reported in previous studies. Starting from late fuel injection timings, combustion stratification is investigated by advancing the fuel injection timings. For late start of injection (SOI), a direct link between SOI and combustion phasing is noticed. At early SOI, combustion phasing depends on both intake air temperature and SOI. In order to match the combustion phasing (CA50) of diesel, the intake air temperature is increased to 90°C for naphtha. The combustion stratification from CI to PPC is also investigated for various level of dilution by displacing oxygen with nitrogen in the intake. The start of combustion (SOC) was delayed with the increase in dilution and to compensate for this, the intake air temperature is increased. The mixture homogeneity is enhanced for higher dilution due to longer ignition delay. The results show that high speed image is initially blue and then turned yellow, indicating soot formation and oxidation. The luminosity of combustion images decreases with early SOI and increased dilution. The images are processed to generate the level of stratification based on the image intensity. The level of stratification is same for diesel and naphtha at various SOI. When O concentration in the intake is decreased to 17.7% and 14

  11. Hírpiacok szimulációja

    OpenAIRE

    Németh, András

    2005-01-01

    Hírtőzsdén olyan, általában elektronikus piacot értünk, ahol különféle jövőbeli eseményekre lehet fogadni. Mint azt már több vizsgálat is megmutatta, ezek a játéktőzsdék alkalmasak arra, hogy a résztvevők rendelkezésére álló elszórt részinformációkat összegyűjtsék, egyetlen árfolyammá alakítsák (információaggregáció), és ezzel előre jelezzék az eseményeket. Jelen tanulmány célja e hírtőzsdék és szereplőinek modellezése, valamint az információaggregáció vizsgálata. Ennek érdekében felépítünk e...

  12. Ciências Humanas e Sociais: ciências moles? A propósito do trabalho científico nesta contemporaneidade

    Directory of Open Access Journals (Sweden)

    Maria Adélia Aparecida de Souza

    2011-07-01

    Full Text Available Este ensaio busca atender uma velha e interminável discussão sobre uma questão que longe de ser científica é, sobretudo, política, qual seja a classificação das ciências. A Geografia tem oscilado nessas classificações: ora é uma ciência humana, social, ora é uma ciência da natureza. Este estímulo é o motivo principal da realização deste ensaio que, inspirado em uma interessante reflexão de Abraham Moles, prêmio Nobel de Matemática, quando sugere que reflitamos com seriedade científica e acadêmica sobre esse debate. Esse autor propõe corajosamente que as ciências humanas sejam elas sim consideradas “ciências duras”. Aqui é defendida a tese de que, dadas as características e dinâmicas do mundo do presente, as classificações carecem de um processo de discussão condizente com a essência do mundo de hoje, que reverte por vezes o conhecimento pré-estabelecido. Sugere-se, por exemplo, nesta perspectiva, que o espaço geográfico, por ser uma instância social, tal como a economia, a política e a cultura, seja considerado uma categoria social de análise e não um palco de realização da vida, como tem sido considerado pela geografia descritiva, completamente ultrapassada pela velocidade do mundo e pelos sistemas técnicos disponíveis. Resumé SCIENCES HUMAINES ET SOCIALES: SCIENCES "MOLLES"? A PROPOS DU TRAVAIL SCIENTIFIQUE DANS LA CONTEMRAINETÉ Ce teste cherche à participer d´une interminable discussion sur question du classement des sciences. Catte discussion, loin d'être scientifique ou académique est uni discussion politique. Une source d'inspiration de cette reflexion a été I'oeuvre de Abraham Moles, Prix Nobel de Mathématique. Eant la Géographie une science que parfois est classée comme science de la nature, parfois comme science humaine et sociale. Catte discussion a inspirée aussi cet article. II attire I' ATTENTION SUR LA necessité, pour cette de prendre en consideration les

  13. Determinants of full vaccination status in a rural community with ...

    African Journals Online (AJOL)

    A child's birth in a health facility (P < 0.001; OR = 0.15, 95%CI = 0.07-0.33), mother's knowledge of the benefits of immunization (P = 0.001; OR = 0.21, 95%CI = 0.08-0.60) a mother being employed (P = 0.003; OR = 2.48, 95%CI =1.32-4.68) and a high birth order (P = 0.002) were significantly associated with full vaccination.

  14. Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

    Science.gov (United States)

    Denholm, Rachel; Schüz, Joachim; Straif, Kurt; Stücker, Isabelle; Jöckel, Karl-Heinz; Brenner, Darren R.; De Matteis, Sara; Boffetta, Paolo; Guida, Florence; Brüske, Irene; Wichmann, Heinz-Erich; Landi, Maria Teresa; Caporaso, Neil; Siemiatycki, Jack; Ahrens, Wolfgang; Pohlabeln, Hermann; Zaridze, David; Field, John K.; McLaughlin, John; Demers, Paul; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Dumitru, Rodica Stanescu; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Kendzia, Benjamin; Peters, Susan; Behrens, Thomas; Vermeulen, Roel; Brüning, Thomas; Kromhout, Hans

    2014-01-01

    Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case–control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20–1.48 and OR, 1.50; 95% CI, 1.21–1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33–4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis “only.” Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case–control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. PMID:25054566

  15. Badania jakości regeneratu ze zużytych mas ze spoiwem organicznym

    Directory of Open Access Journals (Sweden)

    R. Dańko

    2012-12-01

    Full Text Available W publikacji przedstawiono uzupełniające metody badań oraz aparaturę do oceny jakości regeneratu i tych właściwości masformierskich ze spoiwami utwardzanymi chemicznie, przygotowywanych z regeneratem, które są istotne dla kompleksowej oceny procesurecyklingu osnowy. Nowoczesne systemy oceny mas formierskich wymagają bardziej wnikliwego podejścia do czynników decydującychzarówno o ich przydatności technologicznej jak również o wpływie na otaczające środowisko naturalne. W tym kontekście pełna ocenajakości zregenerowanej osnowy wykracza poza zwyczajowo stosowane metody instrumentalne i wymaga ich uzupełnienia o bardziejzaawansowane aparaturowo metody badawcze. Pozwala to szerzej spojrzeć na ocenę zregenerowanej osnowy, zarówno w aspekcie jejużycia do sporządzania mas formierskich, jako substytutu świeżego piasku, ale także pod kątem ochrony środowiska. Do takichnowoczesnych metod można zaliczyć między innymi analizę ziarnową regeneratu za pomocą dyfrakcji laserowej, a także ocenęgazotwórczości masy formierskiej oraz identyfikację rodzaju emitowanych gazów i zawartości w nich gazów z grupy BTEX, które sąszczególnie niebezpieczne z punktu widzenia BHP.

  16. SeDiCI: Servicio de Difusión de la Creación Intelectual

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    Marisa R. de Giusti

    2008-07-01

    Full Text Available Presenta el Servicio de Difusión de la Creación Intelectual (SeDiCI de la Universidad Nacional de La Plata (UNLP, Argentina, desde el punto de vista de los objetivos que condujeron a la UNLP a su creación. Se describen en detalle las etapas por las que se atravesó para poner en marcha este repositorio institucional y especialmente las facilidades que provee el software Celsius-DL desarrollado en la UNLP que soporta el Portal de SeDiCI.

  17. Cloning and Functional Analysis of the MADS-box CiMADS9 Gene from Carya illinoinensis

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    Zhang Jiyu

    2015-07-01

    Full Text Available A MADS-box gene, CiMADS9, was cloned from the male flowers of Carya illinoinensis by rapid amplification of cDNA ends. The gene was 1 077 bp with a 768 bp open reading frame encoding 255 amino acids. Multiple sequence comparisons revealed that CiMADS9 is a typical MIKC-type MADS-box gene with a MADS-box domain and a K semi-conserved region. Phylogenetic analysis indicated that CiMADS9 belongs to the AGL15 group of the MADS-box gene family. Quantitative reverse transcription polymerase chain reaction analysis indicated that the expression levels in reproductive organs (i.e., flowers and young fruits were considerably higher than in vegetative tissues (i.e., leaves and branches. The highest expression levels were observed in male flowers. An overexpression vector for CiMADS9 was constructed and the gene was inserted into the Arabidopsis thaliana genome. CiMADS9 expression was confirmed in all transgenic lines. Compared with wild-type plants, transgenic A. thaliana plants overexpressing CiMADS9 exhibited delayed flowering and an increased number of leaves.

  18. SISTEM PENJUALAN SPARE PART TOKO AJM MOTOR MENGGUNAKAN CI BERBASIS ARSITEKTUR MVC

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    Ade Setiadi

    2016-11-01

    Full Text Available Saat ini penggunaan komputer dan perangkat lunak semakin banyak hingga ke berbagai kehidupan, bahkan sampai pada bidang ekonomi. Sistem Informasi merupakan peranan sangat penting dalam kegiatan bisnis di suatu perusahaan. Toko AJM Motor bergerak dalam bidang penjualan spare part mobil dan masih menggunakan cara yang konvensional dalam mengolah data tentang transaksi penjualan, untuk itu Toko AJM Motor membutuhkan sistem informasi yang dapat menunjang kelancaran dalam melakukan transaksi penjualannya. Dalam dunia teknologi khususnya pemrograman saat ini, baik itu desktop maupun web base semakin marak pengerjaannya menggunakan framework dan salah satu framework berbasis PHP yang banyak digunakan yaitu CodeIgniter (CI. Framework CI memang dikembangkan untuk memudahkan dalam developing aplikasi dengan struktur file source code-nya menggunakan pendekatan arsitektur Models-Views-Controller (MVC dan pemrograman berorientasi objek. Oleh sebab itu, kami menggunakan CI dalam developing aplikasi ini dengan metode Object Oriented Analysis and Design sebagai metode pengembangan system. Dengan dirancangnya sistem ini telah mempermudah pemilik toko dalam mengelola data pelanggan, supplier dan barang yang di beli dan di jual serta pembuatan laporan yang diperlukan untuk perhitungan penjualan dan dapat memberikan informasi yang berguna bagi pemilik toko secara up to date. Kata kunci: codeigniter (CI, models-views-controller (MVC, object oriented, penjualan.

  19. Cancer-Specific and All-Cause Mortality in Kidney Transplant Recipients With and Without Previous Cancer.

    Science.gov (United States)

    Viecelli, Andrea K; Lim, Wai H; Macaskill, Petra; Chapman, Jeremy R; Craig, Jonathan C; Clayton, Philip; Cohney, Solomon; Carroll, Robert; Wong, Germaine

    2015-12-01

    For dialysis patients with a cancer history, a period of surveillance is generally recommended before listing for transplantation. However, the outcomes of patients with cancer recurrence and/or a second primary cancer after transplantation are unknown. To determine the prognosis of kidney transplant recipients who developed cancer after transplantation and whether this varied with cancer types (first cancer, recurrence, second primary cancer). Using data from the Australian and New Zealand Dialysis and Transplant Registry, we compared the cancer-specific and all-cause mortality among recipients with different cancer types using adjusted Cox proportional hazard models. Of the 21,415 recipients transplanted between 1965 and 2012, 3% (651 of 21,415) had a previous cancer history. A total of 2840 (13%) recipients developed cancer after the first transplant, of whom 2760 (97.2%) developed a first cancer, 23 (0.8%) experienced cancer recurrence, and 57 (2%) developed a second primary cancer. There were no significant differences in the risks of cancer-specific and all-cause mortality between recipients who developed their first cancer after transplant, those with cancer recurrence (adjusted hazard ratios [aHRs], 0.79; 95% confidence interval [95% CI], 0.38-1.67; P = 0.54 and aHRs, 0.86; 95% CI, 0.45-1.66; P = 0.66, respectively) and recipients who developed a second primary cancer after transplantation (aHRs, 1.01; 95%CI, 0.63-1.62; P = 0.95 and aHRs, 1.16; 95% CI, 0.79-1.69; P = 0.45, respectively). Among patients with a previous history of malignancy, recurrent and second primary cancers are infrequent after renal transplantation. A history of previous malignancy does not have an additive effect on the cancer-specific and overall survival of kidney transplant recipients who develop cancer.

  20. Obstetric Outcomes of Mothers Previously Exposed to Sexual Violence.

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    Agnes Gisladottir

    Full Text Available There is a scarcity of data on the association of sexual violence and women's subsequent obstetric outcomes. Our aim was to investigate whether women exposed to sexual violence as teenagers (12-19 years of age or adults present with different obstetric outcomes than women with no record of such violence.We linked detailed prospectively collected information on women attending a Rape Trauma Service (RTS to the Icelandic Medical Birth Registry (IBR. Women who attended the RTS in 1993-2010 and delivered (on average 5.8 years later at least one singleton infant in Iceland through 2012 formed our exposed cohort (n = 1068. For each exposed woman's delivery, nine deliveries by women with no RTS attendance were randomly selected from the IBR (n = 9126 matched on age, parity, and year and season of delivery. Information on smoking and Body mass index (BMI was available for a sub-sample (n = 792 exposed and n = 1416 non-exposed women. Poisson regression models were used to estimate Relative Risks (RR with 95% confidence intervals (CI.Compared with non-exposed women, exposed women presented with increased risks of maternal distress during labor and delivery (RR 1.68, 95% CI 1.01-2.79, prolonged first stage of labor (RR 1.40, 95% CI 1.03-1.88, antepartum bleeding (RR 1.95, 95% CI 1.22-3.07 and emergency instrumental delivery (RR 1.16, 95% CI 1.00-1.34. Slightly higher risks were seen for women assaulted as teenagers. Overall, we did not observe differences between the groups regarding the risk of elective cesarean section (RR 0.86, 95% CI 0.61-1.21, except for a reduced risk among those assaulted as teenagers (RR 0.56, 95% CI 0.34-0.93. Adjusting for maternal smoking and BMI in a sub-sample did not substantially affect point estimates.Our prospective data suggest that women with a history of sexual assault, particularly as teenagers, are at increased risks of some adverse obstetric outcomes.

  1. Engineering of a genetically encodable fluorescent voltage sensor exploiting fast Ci-VSP voltage-sensing movements.

    Directory of Open Access Journals (Sweden)

    Alicia Lundby

    2008-06-01

    Full Text Available Ci-VSP contains a voltage-sensing domain (VSD homologous to that of voltage-gated potassium channels. Using charge displacement ('gating' current measurements we show that voltage-sensing movements of this VSD can occur within 1 ms in mammalian membranes. Our analysis lead to development of a genetically encodable fluorescent protein voltage sensor (VSFP in which the fast, voltage-dependent conformational changes of the Ci-VSP voltage sensor are transduced to similarly fast fluorescence read-outs.

  2. Somatyczna determinacja płciowa w nadwadze i otyłości

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    Michał Zych

    2015-12-01

    Full Text Available Wstęp: Somatyczne wielkości, takie jak masa (Mc i wysokość ciała (Wc, są używane do wyliczania wskaźników wagowo--wzrostowych i stanowią pomoc w diagnozowaniu nadwagi i otyłości. Cel pracy: Celem pracy jest ocena nadwagi i otyłości kobiet i mężczyzn w świetle prostych wskaźników somatycznych. Materiał i metody: W prezentowanej pracy porównano wskaźniki somatyczne 179 kobiet i 181 mężczyzn z nadwagą i otyłością. Do oceny somatycznej badanych użyto: Mc, Wc oraz wskaźników wagowo-wzrostowych: Queteleta, BMI, Rohrera i smukłości. Wyniki: W badanych grupach kobiety i mężczyźni byli w zbliżonym wieku, grupy te różniły się istotnie omawianymi wskaźnikami somatycznymi. Porównania podgrup kobiet i mężczyzn o podobnej wielkości BMI wykazały, że są oni w podobnym wieku i różnią się w zakresie Mc, Wc oraz wskaźników: Queteleta, Rohrera i smukłości. Natomiast między podgrupami kobiet, jak i między podgrupami mężczyzn, występowały istotne różnice wiekowe, Mc oraz wskaźników: BMI, Queteleta, Rohrera i smukłości. Wnioski: Powyższe dane wskazują, że pomimo braku różnic wieku między badanymi kobietami i mężczyznami z podobnym lub różnym BMI istnieje wyraźna somatyczna determinacja płciowa, natomiast w obrębie tej samej płci, różniącej się wskaźnikiem BMI, wiek badanych jest czynnikiem determinacji somatycznej. Wykazano też, że badane wskaźniki somatyczne mają różną moc predykcyjną w zakresie oceny nadwagi i stopnia otyłości badanych kobiet i mężczyzn.

  3. Ocena efektywności podziału subwencji oświatowej dla gmin

    Directory of Open Access Journals (Sweden)

    Jan Herczyński

    2016-06-01

    Full Text Available Celem przedstawionych analiz jest ocena dopasowania podziału pomiędzy gminy części oświatowej subwencji ogólnej do kosztów dostarczania usług edukacyjnych. W artykule zarysowano problematykę związaną z podziałem subwencji oświatowej pomiędzy gminy, opisano wagi stosowane w algorytmie podziału subwencji oświatowej, skoncentrowano się na zmianach wprowadzonych do algorytmu w 2015 r. i omówiono konsekwencje wynikające ze stosowania wag wiejskich, które mają stosunkowo duży wpływ na podział środków. W ostatniej części wprowadzono miarę nieefektywności algorytmu podziału części oświatowej subwencji ogólnej i zastosowano ją do oceny podziału środków subwencyjnych pomiędzy gminy. Miara ta pozwala m.in. ilościowo ocenić efekt zmian wprowadzonych do algorytmu w 2015 r. Zaproponowano możliwe korekty wag algorytmu pozwalające na redukcję nieefektywności i zjawiska tzw. przewrotnej motywacji organów prowadzących szkoły. W podsumowaniu przedstawiono główne wnioski wynikające z analiz.

  4. DNA damage in isolated rat hepatocytes exposed to C.I. pigment orange 5 and C.I. pigment yellow 12 by the alkaline comet assay

    DEFF Research Database (Denmark)

    Møller, P; Wallin, Håkan; Grunnet, N

    1998-01-01

    The induction of DNA damage by commonly used printing ink pigments, C.I. pigment orange 5 (C.I. 12075) and C.I. pigment yellow 12 (C.I. 21090), was investigated in freshly isolated rat hepatocytes with the comet assay. C.I. pigment yellow 12 is a 3,3'-dichlorobenzidine-based diarylide pigment...

  5. Fazer ciência: o lugar do conceito

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    Wilton Garcia

    2007-06-01

    Full Text Available Este texto visa abrir uma discussão acerca da pesquisa contemporânea, investindo o enfoque no discurso científico para uma abordagem dinâmica de estratégias discursivas. Tento realizar uma reflexão crítica sobre a produção do saber em alguns procedimentos conceituais. Neste caso, remeto o olhar a uma consideração teórico-metodológica que pretende contribuir à atualização do discurso da ciência, hoje, e permita propor maior flexibilidade e deslocamento diante das diferentes produções de conhecimento. Este trabalho, portanto, não pretende expor, diretamente, idéias sobre ciência, mas sobre o discurso dito científico. Nesta investigação crítica, apresento sucintamente a noção de pós-(desconstrução. Utilizo os estudos contemporâneos como eixo teórico-metodológico para este desenvolvimento argumentativo. Os estudos contemporâneos pesquisam as atualizações de conceitos, que se organizam mediante a produção de atualidades e vasculham uma (redimensão teórica e política, associada ao sistema flexível da linguagem. Essas atualizações esboçam a área dos estudos contemporâneos em sua intensidade descritiva, quando aciona um olhar investigativo sobre as inovações no discurso científico, hoje.

  6. A concepção de ciência de Popper e o ensino de ciências Popper's conception of science and the teaching of sciences

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    Carlos Alberto Rufatto

    2009-01-01

    Full Text Available Procurou-se identificar as consequências mais importantes da concepção de ciência de Popper, que deu origem a um rico debate na Filosofia das Ciências, para o Ensino de Ciências. O acompanhamento deste debate permite perceber a riqueza do processo científico, reconhecendo as contribuições daqueles que debateram com Popper; bem como a importância dos aspectos da ciência que Popper valorizou e procurou preservar. As críticas e os debates em torno das abordagens de mudança conceitual contribuíram para a percepção da riqueza e complexidade desse processo. Quando considerados os objetivos institucionais das escolas e as expectativas sociais em torno da compreensão adequada e da procura de superação dos paradigmas vigentes a manutenção de certos aspectos, inerentes ao processo de mudança conceitual, pode se mostrar relevante. Neste sentido, a obra de Popper pode oferecer importante apoio para valorizar aspectos racionais que poderiam presidir o processo de aprender Ciências.This work aimed at identifying the most important consequences of Popper's conception of science education, which started a fertile debate in the Philosophy of Science. By following this debate, it is possible to notice the richness of the cientific process, recognizing the contributions brought by those who debated with Popper, and the importance of aspects of science that Popper valued and attempted to preserve. The criticism and the debate over the approaches towards conceptual change contributed to the perception of the wide extent and complexity of this process. However, the maintenance of certain aspects, inherent in the process of conceptual change, may be relevant when the institutional objectives of the schools and the social expectations over the appropriate understanding and over the attempt to overcome current paradigms are considered. In this way, Popper's work may offer important support to valuing rational aspects that could inform the process

  7. Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens.

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    Luis F López-Cortés

    Full Text Available Significant controversy still exists about ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv as a simplification strategy that is used up to now to treat patients that have not experienced previous virological failure (VF while on protease inhibitor (PI -based regimens. We have evaluated the effectiveness of two mtPI/rtv regimens in an actual clinical practice setting, including patients that had experienced previous VF with PI-based regimens.This retrospective study analyzed 1060 HIV-infected patients with undetectable viremia that were switched to lopinavir/ritonavir or darunavir/ritonavir monotherapy. In cases in which the patient had previously experienced VF while on a PI-based regimen, the lack of major HIV protease resistance mutations to lopinavir or darunavir, respectively, was mandatory. The primary endpoint of this study was the percentage of participants with virological suppression after 96 weeks according to intention-to-treat analysis (non-complete/missing = failure.A total of 1060 patients were analyzed, including 205 with previous VF while on PI-based regimens, 90 of whom were on complex therapies due to extensive resistance. The rates of treatment effectiveness (intention-to-treat analysis and virological efficacy (on-treatment analysis at week 96 were 79.3% (CI95, 76.8-81.8 and 91.5% (CI95, 89.6-93.4, respectively. No relationships were found between VF and earlier VF while on PI-based regimens, the presence of major or minor protease resistance mutations, the previous time on viral suppression, CD4+ T-cell nadir, and HCV-coinfection. Genotypic resistance tests were available in 49 out of the 74 patients with VFs and only four patients presented new major protease resistance mutations.Switching to mtPI/rtv achieves sustained virological control in most patients, even in those with previous VF on PI-based regimens as long as no major resistance mutations are present for the administered drug.

  8. Decreasing prevalence of the full metabolic syndrome but a persistently high prevalence of dyslipidemia among adult Arabs.

    Directory of Open Access Journals (Sweden)

    Nasser M Al-Daghri

    Full Text Available A decade has passed since metabolic syndrome (MetS was documented to be highly prevalent in the kingdom of Saudi Arabia. No follow-up epidemiologic study was done. This study aims to fill this gap. In this cross-sectional, observational study, a total of 2850 randomly selected Saudi adults aged 18-55 years were recruited. Subjects' information was generated from a database of more than 10,000 Saudi citizens from the existing Biomarkers Screening in Riyadh Program (RIYADH Cohort, Saudi Arabia. Anthropometrics included body mass index (BMI, blood pressure, as well as waist and hip circumferences. Fasting blood glucose and lipid profile were determined using routine laboratory procedures. The definition of ATP-III (NHANES III was used for the diagnosis of the full MetS. The overall prevalence of complete MetS was 35.3% [Confidence-Interval (CI 33.5-37.01]. Age-adjusted prevalence according to the European standard population is 37.0%. Low HDL-cholesterol was the most prevalent of all MetS risk factors, affecting 88.6% (CI 87.5-89.7 and hypertriglyceridemia the second most prevalent, affecting 34% (CI 32.3-35.7 of the subjects. The prevalence of the full MetS decreased from previous estimates but remains high, while dyslipidemia remains extremely high, affecting almost 90% of middle-aged Arabs. Screening for dyslipidemia among Saudi adults is warranted, especially among those most at risk. Scientific inquiry into the molecular causes of these manifestations should be pursued as a first step in the discovery of etiologic therapies.

  9. Mitos da didática das ciências acerca dos motivos para incluir a Natureza da Ciência no ensino das ciências Science Education myths about the reasons to include the Nature of Science in science teaching

    Directory of Open Access Journals (Sweden)

    J. A. Acevedo

    2005-04-01

    Full Text Available Em certas situações, a Didática das Ciências transmite como mitos algumas crenças que não estão suficientemente sustentadas pela investigação que ela própria produz. Este artigo mostra dois desses mitos relacionados com os motivos que se costumam apontar para incluir a Natureza da Ciência no ensino das ciências, como sejam a suposta relação entre a prática docente e as crenças sobre a Natureza da Ciência, e a crença de que a sua compreensão é um fator chave na hora de tomar melhores decisões cívicas em questões tecnocientíficas de interesse social. A análise que se apresenta realizou-se mediante a revisão de diversos resultados de investigações procedentes da própria Didática das Ciências e também da Psicologia das Decisões. A conclusão aponta para considerar que outros fatores influenciam mais, tornando muito menos lineares essas hipotéticas relações do que alguns especialistas pensam e mais complexa a problemática abordada.In some situations Science Education transmits as myths various beliefs as myths that are not enough sustained by the research in its own domain. This paper shows two of these myths related to the reasons usually pointed in orderfor includinge the Nature of Science in science teaching:, such as the supposed relationship between the educational practice and the beliefs about the Nature of Science, and also the belief that its understanding of the Nature of Science is a key factor in when making better civicdecisions as citizens in technical socioscientific oscientific issues. with social interest The analysis was carried out by means of athe review of several results from the own Science Education Research, and also from the Psychology of Decisions. The conclusion seems to be clear: other factors are of a greater influence, making those hypothetical relations much less linear than some experts wcould think, and making the questions much more complex. the presented question.

  10. Por uma ciência formativa e indiciária: proposta epistemológica para a ciência da informação Formative science and indicial science: epistemological proposal for information science

    Directory of Open Access Journals (Sweden)

    Eliany Alvarenga de Araújo

    2006-01-01

    Full Text Available Reflexão epistemológica sobre a Ciência da Informação como “fazer científico” que se estrutura na Ciência Moderna, em termos teóricos e metodológicos e nas Tecnologias daInformação, em termos aplicados. Tal configuração possibilitou o surgimento desta ciência, porém consideramos que a mesma não garantirá à mesma o pleno desenvolvimento comocampo de conhecimento consistente e moderno. A Ciência Moderna, enquanto visão e prática científica encontra-se esgotada e as Tecnologias de Informação são apenas mecanismos autoregulados que funcionam segundo princípios de automatismos. A partir destas considerações propomos o conceito de ciência formativa (Bachelard, 1996 e o paradigma indiciário (Ginzburg, 1991 como bases teóricas e metodológicas para uma epistemologia da Ciência da Informação. O conceito de ciência formativa se baseia no principio dos três estados do espírito científico e nas condições psicológicas do progresso científico e o paradigma indiciário propõe a intuição (empírica e racional como base metodológica para o fazer científico.Epistemological reflections on the Information Science as scientific field that if structure in the context of modern science, in theoretical and methodological terms and technologies of the information in applied terms. Such configuration made possible the sprouting of this science; however we consider that the same one will not guarantee to this science the full development as field of consistent and modern knowledge. Modern Science, while scientific practical vision and meets depleted and the information technologies are only auto-regulated mechanisms that function according to principles of automatisms. To leave of these considerations we propols the concept of Formative Science (Bachelard, 1996 and the Indiciario Paradigm (1991 with epistemological basis for the Information Science. The concept of formative science if a base on the principles of tree

  11. Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?

    DEFF Research Database (Denmark)

    Gade, Malene R; Goukasian, Irina; Panduro, Nathalie

    2018-01-01

    Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev...... University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis....... Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4% (95% CI: 2.8-14.1%), vaginal dryness by 28.4% (95% CI: 19...

  12. IOTA interferometer observations of the B[e] star/X-ray transient object CI Cam.

    Science.gov (United States)

    Thureau, N. D.; Traub, W.; Millan-Gabet, R.; Monnier, J. D.; Pedretti, E.; Berger, J.-P.; Schloerb, P.

    2005-12-01

    We present the results from an observing campaign on the star CI Cam carried out at the IOTA interferometer in November-December 2004 using the IONIC 3 telescope beam combiner in the H spectral band with projected baselines in the range 10-36m. CI Cam is a known B[e] star and X-ray transient source and has been intensively observed since its powerful X-ray, radio and optical outburst occurred in April 1998. Our visibility measurements put strong constraints on the nature of the source and we can rule out all existing SED models available in the literature. Our new results are in agreement with previous observations of CI Cam obtained with IOTA2 in the H and K' spectral bands in September-November 1998, indicating the infrared excess is long-lived and not directly associated with the outburst. We have explored new models that can better fit our observations. Additionally, we have measured small non-zero closure phases which are the signature of asymmetries in the brightness distribution function. Financial support for NDT is provided by the European Commission through a Marie Curie Outgoing International Fellowships MOIF-CT-2004-002990.

  13. Trophic analysis of the fish community in the Ciénega Churince, Cuatro Ciénegas, Coahuila

    Directory of Open Access Journals (Sweden)

    Ariana Hernández

    2017-09-01

    Full Text Available Fish diets were analyzed to evaluate the dynamic trophs of the fish community in the Churince wetland system of the Cuatro Ciénegas, where the fauna consists of nine species: endemic, native and introduced. In nine sampling events (between February 2011 and May 2014 556 specimens of all nine species were collected. Stomach contents were analyzed and the Relative Importance Index (IRI was calculated. The feed coefficient (Q of the diets and the accumulated trophic diversity (Hk, as well as the amplitude of the trophic niche were evaluated. Feeding strategies in the fish community were found to be eurifagic. The main foods in general were insects, crustaceans, gastropods, plants and teleosts. According to the average linkage method, four functional trophic groups were defined, with no higher consumption species; nevertheless all were regulators, mainly invertebrates. Therefore, the chain reaction in food control was higher from top to bottom, meaning a downwards dietary control.

  14. Adolescents' physical activity is associated with previous and current physical activity practice by their parents

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    Diego Giulliano Destro Christofaro

    Full Text Available Abstract Objective: The purpose of this study was to determine whether parents' current and previous physical activity practice is associated with adolescents' physical activity. Methods: The sample was composed of 1231 adolescents (14-17 years, and 1202 mothers and 871 fathers were interviewed. Weight and height of the adolescents were measured. Self-reported parents' weight and height were obtained. The current and previous physical activity levels (Baecke's questionnaire of parents (during childhood and adolescence and adolescents' physical activity levels were obtained using a questionnaire. The magnitude of the associations between parent and adolescent physical activity levels was determined by binary logistic regression (adjusted by sex, age, and socioeconomic level of adolescents and education level of parents. Results: The current physical activity practice by parents was associated with adolescents' physical activity (p < 0.001. The physical activities reported by parents in their childhood and adolescence were also associated with higher physical activity levels among adolescents. Adolescents whose parents were both physically active in the past and present were six times (OR = 6.67 [CI = 1.94-22.79] more likely to be physically active compared to adolescents with no parents who were physically active in the past. Conclusions: The current and previous physical activities of parents were associated with higher levels of physical activity in adolescents, even after controlling for confounding factors.

  15. Filosofia da ciência como ferramenta microeconômica

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    Fabio Barbieri

    2009-06-01

    Full Text Available A teoria neoclássica pressupõe conhecimento perfeito. A crítica hayekiana a essa teoria, por sua vez, afirma que esse conhecimento é resultado do processo competitivo e, portanto, não pode ser considerado como dado. O “Problema de Hayek” investiga sob que condições o conhecimento do agente se aproxima dos reais fundamentos de uma economia. A fim de solucionar o “Problema de Hayek”, o nosso artigo utiliza algumas idéias da literatura de metodologia da Ciência, conhecida como teoria do “crescimento do conhecimento” (Popper, Kuhn, Lakatos e outros. Essas idéias são utilizadas para se compreender como evolui o conhecimento dos agentes econômicos, em especial o dos empresários. Estes são vistos como ativos formuladores de teorias empresariais conjecturais criticadas no processo competitivo, não como agentes passivos que maximizam funções já conhecidas da teoria convencional. Utiliza-se a Filosofia da Ciência não para analisar metodologicamente a microeconomia, mas, sim, como ferramenta analítica pertencente à própria teoria econômica.

  16. Diversidade sexual e ensino de ciências: buscando sentidos

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    Leandro Jorge Coelho

    2015-12-01

    Full Text Available ResumoO objetivo desse estudo foi analisar os sentidos atribuídos por professores de Ciências e alunos à diversidade sexual. Foram utilizados: questionário, entrevista, produção de textos, análise documental e a técnica de grupo focal para a coleta de dados. De modo geral, os alunos possuem sentidos que reconhecem Lésbicas, Gays, Bissexuais e Transgêneros (LGBT como "estranhos", mesmo assim, acreditam que têm o dever de respeitar as escolhas de cada um. As travestis foram declaradamente apresentadas com repúdio por eles, sendo a homossexualidade e bissexualidade aparentemente mais aceitas. Os professores parecem manter aulas que não abordam estas questões, mesmo o Ensino de Ciências, sendo um momento privilegiado para problematizações sobre diversidade sexual e gênero. É necessário investir em discussões sobre esses temas na formação inicial e continuada de professores, buscando a construção de novos sentidos e práticas que se preocupem com o desvelamento de significados preconceituosos sobre gênero e diversidade sexual.

  17. Problem wolności w Internecie / The problem of freedom in Internet

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    Iwona Gleisner

    2013-07-01

    Full Text Available Artykuł jest próbą odpowiedzi na pytanie o granice wolności w Internecie. Dyskusje ten temat, toczące się na całym świecie od dawna, nie dały dotąd zadowalającej odpowiedzi. W ostatnich latach przybiera na sile spór pomiędzy zwolennikami pełnej swobody, a stronnikami prawnego ograniczania korzystania z zasobów globalnej sieci. Autorka przytacza argumenty obu stron konfliktu, zwracając uwagę na potrzebę znalezienia równowagi prawnej pomiędzy interesami twórców, a potrzebami odbiorców. Porusza ponadto istotne zagadnienie moralnej odpowiedzialności autorów za zamieszczane w Internecie treści.English abstractThis paper attempts to find an answer to the question about freedom in Internet. This issue has been discussed all over the world for long, however no satisfactory answer has yet been found. Recently, the dispute between the supporters of the full freedom and the ones voting for limiting the resources of the global network with legal means has been becoming more fierce. The author quotes arguments of both parties to the conflict, drawing attention to the need of finding a legal balance between the interests of the artists and the needs of the consumers. She also tackles with an important issue of moral responsibility of the authors for the contents placed in Internet. Normal 0 21 false false false PL X-NONE X-NONE

  18. How to prevent type 2 diabetes in women with previous gestational diabetes?

    DEFF Research Database (Denmark)

    Pedersen, Anne Louise Winkler; Terkildsen Maindal, Helle; Juul, Lise

    2017-01-01

    OBJECTIVES: Women with previous gestational diabetes (GDM) have a seven times higher risk of developing type 2 diabetes (T2DM) than women without. We aimed to review the evidence of effective behavioural interventions seeking to prevent T2DM in this high-risk group. METHODS: A systematic review...... of RCTs in several databases in March 2016. RESULTS: No specific intervention or intervention components were found superior. The pooled effect on diabetes incidence (four trials) was estimated to: -5.02 per 100 (95% CI: -9.24; -0.80). CONCLUSIONS: This study indicates that intervention is superior...... to no intervention in prevention of T2DM among women with previous GDM....

  19. Laparoscopy After Previous Laparotomy

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    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  20. As diferentes faces da razão (II. Risco, ciência e peritos

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    C. M. Novais Madureira

    2012-10-01

    Full Text Available Em texto anterior argumentou-se contra os excessos do cientismo com que, na linha de Sokal e Bricmont, António Manuel Baptista ataca as análises sociológicas dos processos e produtos da ciência, nomeadamente as posições de Boaventura de Sousa Santos. Neste outro texto, pretende-se contestar AMB e os sokalistas no seu próprio campo, o da ciência pura e dura, mostrando que eles próprios não compreendem o estatuto das suas ciências, e tentando ponderar afirmações menos precisas, frequentes na análise da sociogénese da ciência. Trazendo a discussão para o nosso tempo, abordaremos também uma problemática não tratada no texto anterior, a do estatuto dos cientistas e tecnólogos enquanto peritos nas instâncias de decisão. Por último, tratará de analisar-se como as controvérsias entre peritos, hoje tão frequentes, são vividas no seio da comunidade científica e qual a evolução que geram na própria prática pericial.

  1. Paclitaxel with Cisplatin as Salvage Treatment for Patients with Previously Treated Advanced Transitional Cell Carcinoma of the Urothelial Tract

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    Ji Eun Uhm

    2007-01-01

    Full Text Available BACKGROUND: This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C for advanced transitional cell carcinoma (TCC of the urothelial tract. METHODS: Twenty-eight patients with metastatic or locally advanced TCC who had received prior G/C chemotherapy were enrolled. All patients received paclitaxel (175 mg/m2 and cisplatin (60 mg/m2 every 3 weeks for eight cycles or until disease progression. RESULTS: The median age was 61 years (range, 43–83 years, and the median Eastern Cooperative Oncology Group performance status was 1 (range, 0–2. The overall response rate was 36% [95% confidence interval (95% CI = 18–54], with three complete responses and seven partial responses. The median time to progression was 6.2 months (95% CI = 3.9–8.5, and the median overall survival was 10.3 months (95% CI = 6.1–14.1. The most common Grade 3/4 nonhematologic and hematologic toxicities were emesis (10 of 28 patients; 36% and neutropenia (5 of 110 cycles; 5%. CONCLUSIONS: Salvage chemotherapy with paclitaxel and cisplatin displayed promising results with tolerable toxicity profiles in patients with metastatic or locally advanced TCC who had been pretreated with G/C.

  2. Radio emission from symbiotic variables: CI Cygni, Z Andromedae, and EG Andromedae - Temporal variability as clues to the nature of symbiotics

    International Nuclear Information System (INIS)

    Torbett, M.V.; Campbell, B.

    1989-01-01

    A continuing survey of interacting binary systems has yielded first detections of the symbiotic variables CI Cyg and EG And and reproduced previous flux measurements for Z And. The CI Cyg observation implies considerable radio variability for some symbiotics, while the radio flux from Z And indicates this object has been reasonably stable in the radio for years. Rapid radio variability may indicate the presence of mass transfer through an accretion disk. 27 refs

  3. Evaluation of radioiodine therapy with fixed doses of 10 and 15 mCi in patients with Graves disease; Avaliacao da radioiodoterapia com doses fixas de 10 e 15 mCi em pacientes com doenca de Graves

    Energy Technology Data Exchange (ETDEWEB)

    Canadas, Viviane; Vilar, Lucio; Moura, Eliane; Brito, Ana; Castellar, Enio [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Hospital das Clinicas. Servico de Endocrinologia]. E-mail: vivi2207@ig.com.br

    2007-10-15

    The treatment options for the hyperthyroidism of Graves' disease are antithyroid drugs, surgery and radioiodine, none of which is considered ideal, as they do not act directly on the etiopathogenesis of the disease. Radioiodine has been increasingly used as the treatment of choice because it is a safe and definitive therapy whose administration is very easy. Some authors prefer to administer higher doses in order to deliberately induce hypothyroidism, while others recommend lower doses that result in a lower incidence of hypothyroidism and a greater incidence of euthyroidism. There is no consensus for the optimal regimen of fixed doses to be used and this is the main focus of the present study, where doses of 10 and 15 mCi of {sup 131}I were compared. Among the 164 patients analyzed, 61 (37.2%) were submitted to 10 mCi and 103 (62.8%) to 15 mCi. In the longitudinal analysis it was observed that remission of the hyperthyroidism was statistically different in the sixth month (p < 0.001), being higher in the group that used the dose of 15 mCi, but similar in both groups at 12 and 24 months. It may be concluded that the administration of fixed doses of 10 and 15 mCi of {sup 131}I brought about a similar remission of the hyperthyroidism after 12 months of treatment. Moreover, the remission rate of the hyperthyroidism had no association with age, sex or previous therapy with antithyroid drugs. (author)

  4. ANALIZA PRACY INSTALACJI FOTOWOLTAICZNEJ W ZALEŻNOŚCI OD ORIENTACJI GEOGRAFICZNEJ

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    Ewelina KRAWCZAK

    Full Text Available Rynek odnawialnych źródeł energii z każdym dniem coraz bardziej się rozwija. Zapotrzebowanie na energię elektryczną wzrasta, przy czym zasoby konwencjonalnych i zarazem nieodnawialnych źródeł energii (paliw kopalnych ulegają zubożeniu. Alternatywą dla nich są odnawialne źródła energii (OZE, których rezerwy uzupełniane są w naturalnych procesach ekosystemu, co stanowi o ich niewyczerpalności. Zmiany legislacyjne w Polsce dotyczące OZE spowodowały duże zainteresowanie małymi instalacjami fotowoltaicznymi w wyniku czego dotychczasowy konsument zmienia się w prosumenta energii elektrycznej. Rozwój rynku odnawialnych źródeł energii stawia przed projektantami ciągłe wyzwania, ponieważ projektowanie instalacji fotowoltaicznych o wysokiej wydajności dla istniejących budynków, przy uwzględnieniu występujących lokalnych warunków oraz architektury budowli, jest niezwykle trudne. Uzysk energetyczny systemu słonecznego zależy od wielu czynników, jednym z najważniejszych jest wartość nasłonecznienia zależna od lokalizacji (szerokości geograficznej, a także orientacja projektowanego systemu względem kierunku azymutu. Narzędziem wspomagającym i usprawniającym projektowanie instalacji PV (Photovoltaics jest oprogramowanie DDS-CAD, pozwalające przeprowadzić symulację uzysków energii elektrycznej. Wyniki otrzymanych symulacji umożliwiają w krótkim czasie porównanie wielu wirtualnych modeli instalacji pod kątem wydajności, a co za tym idzie wybranie najkorzystniejszego wariantu dla istniejącej orientacji geograficznej. W niniejszej pracy poddane zostały analizie rezultaty symulacji wirtualnych modeli instalacji fotowoltaicznych pod względem liczby generatorów fotowoltaicznych oraz wielkości uzysku energii elektrycznej przy założeniu wykorzystania całej powierzchni dachu oraz uwzględnieniu zmiany kąta usytuowania modułów PV względem okapu połaci dachowej i kierunku azymutu.

  5. Language Practices in the Ci-Classroom

    DEFF Research Database (Denmark)

    Mourtou, Eleni

    2014-01-01

    Prelingually deafened children are nowadays likely to receive a cochlear implant (ci). As these children do their language acquisition with a cochlear implant they require a constant rehabilitation and support. Educational staff is instructed on how to work with children with ci in form...... of guidelines and workshops. This paper discusses language practices used in the setting of a school for cochlear-implanted children. These children encounter language and pronunciation problems that accompany prelingual deafness and hearing with a cochlear implant. I examine two practices, which are used...

  6. Możliwości leczenia kamicy moczowodowej u dzieci

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    Ewa Straż-Żebrowska

    2010-09-01

    Full Text Available Kamicą układu moczowego nazywamy schorzenie, w którym wytwarzane są złogi w obrębie nerek lub dróg moczowych. Obecnie obserwuje się wzrost częstości występowania kamicy. Szacuje się, iż częstość występowania kamicy układu moczowego wynosi 0,5-5% w grupie dorosłych i 0,1-5% u dzieci. Istotnym problemem jest wykrywanie złogów u małych dzieci, również u niemowląt. Biorąc pod uwagę coraz częstsze wykrywanie kamicy układu moczowego, jej nawrotowość i powikłania, ważne jest wypracowanie schematów leczniczych skutecznych i jednocześnie bezpiecznych, nawet przy konieczności ich kilkukrotnego powtarzania. Postępowanie zachowawcze jest skuteczne w 80%, w przypadkach złogów o wielkości do 4 mm. Powszechnie stosowane do lat 80. XX wieku leczenie operacyjne związane z nacięciem miąższu nerki obecnie w większości przypadków zastępowane jest metodami mniej inwazyjnymi, takimi jak ESWL, PCNL, URSL, a wskazania do leczenia chirurgicznego kamicy zostały znacznie ograniczone. W niniejszej pracy przedstawiono przypadek pacjentki z kamicą układu moczowego leczonej kilkakrotnie metodą ESWL bez efektu, a następnie z uwagi na obecność złogów w moczowodzie za pomocą URSL. Jednym z powikłań po zabiegu ESWL może być „droga kamieni”. Po wykonaniu zabiegu ESWL pacjent wymaga monitorowania poprzez wykonywanie badań USG, co pozwala na szybkie uwidocznienie powikłania w postaci „drogi kamieni” i wdrożenie dodatkowego postępowania ułatwiającego wydalenie złogów. „Droga kamieni” może spowodować utrudnienie odpływu moczu, co może być przyczyną dolegliwości bólowych oraz różnego stopnia poszerzeń moczowodów i układów kielichowo-miedniczkowych. Często wymaga interwencji zabiegowej w trybie pilnym. W ciągu ostatnich dwudziestu lat nastą- piły w Polsce znaczne zmiany w sposobach leczenia kamicy moczowodowej. Rutynowo stosuje się URSL i ESWL, do rzadkości natomiast należy zak

  7. Projeto Caminhão da Ciência: Popularização da Ciência no Oeste da Bahia

    Directory of Open Access Journals (Sweden)

    E. C. V. de Magalhães

    2014-11-01

    Full Text Available O Projeto Caminhão da Ciência tem por objetivo promover a divulgação científica em Escolas e espaços públicos da Região Oeste da Bahia. O projeto teve início no ano de 2009, com apoio do CNPq, ocorrendo a sua primeira apresentação no ano de 2010, na feira libre de Barreiras. Várias áreas do conhecimento são contempladas entre eles: Biologia, Física, Química, Matemática, Geologia e Engenharias. O projeto se fundamenta por apresentações de temáticas desenvolvidas por alunos de graduação, sob a orientação de professores da Universidade Federal do Oeste da Bahia-UFOB, envolvidos no projeto. Diversas temáticas são desenvolvidas na forma trabalhos interdisciplinares entre eles: elaboração de maquetes, experimentos com uso de materiais alternativos, vídeos, jogos e ainda informativos em websites e webblogs. Para as apresentações do projeto, são realizadas visitas nas escolas ou outros espaçoes e os materiais trasportados no Caminhão são montados no espaço físico disponibilizado, criando um cenário similar ao de uma feira de ciências. Neste trabalho são apresentados relatos de apresentações realizadas em Escolas, enfatizando os resultados obtidos que demonstram a socialização do conhecimento científico entre os monitores e a comunidade assistida, além da interação entre a Universidade e a sociedade.

  8. Co jest stawką mobilności pracy? Granice, migracje, współczesny kapitalizm

    Directory of Open Access Journals (Sweden)

    Sandro Mezzadra

    2016-09-01

    Full Text Available Prezentowany tekst rozpoczyna się od krótkiego omówienia kilku wpływowych badań na temat mobilności pracy w ramach historycznego i współczesnego kapitalizmu. Później, opierając się na ustaleniach z ostatniej książki autora, Border as Method, or, the Multiplication of Labour (napisanej razem z Brettem Neilsonem, przechodzi do namysłu nad znaczeniem upowszechnienia się granic w epoce globalizacji z perspektywy „późnego” kapitalizmu. W ostatniej części autor skupia się na podmiotowym wymiarze polityki migracji, dostarczając w tym kontekście wielu przykładów z różnych części świata (w tym z regionu Pacyfiku.

  9. A nova convergência da ciência e da tecnologia

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    Esper A. Cavalheiro

    2007-07-01

    Full Text Available A ação sinérgica dos quatro campos científicos e tecnológicos que apresentaram crescimento acelerado nas últimas décadas - nanotecnologia, biotecnologia, tecnologias de comunicação e informação e ciências cognitivas (neurociência - tem sido intitulada Convergência Tecnológica. Este artigo faz uma revisão das principais discussões que vêm ocorrendo na comunidade científica internacional sobre o seu desenvolvimento e assinala a necessidade de uma abordagem mais ampla que inclua as ciências humanas e sociais e outros atores relevantes na sociedade contemporânea.The synergic combination of the scientific and technological fields that presented a rapid growth rate in the last few decades - nanotechnology, biotechnology, information and communication technologies, and cognitive science including neuroscience - is nowadays known as Convergent Technologies. This paper reviews its recent impact on the international scientific community and points out the need of amplifying the discussions to include humanities and social sciences and other important actors of contemporary society.

  10. Możliwości wykorzystania MSSF 9 do kształtowania wyniku finansowego jednostki gospodarczej

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    Maciej Frendzel

    2016-09-01

    Full Text Available Artykuł podejmuje problematykę zastosowania Międzynarodowego Standardu Sprawozdawczości Finan- sowej (MSSF 9 Instrumenty finansowe w kontekście możliwości wykorzystania przewidzianych w nim rozwiązań do uzyskania pożądanych rezultatów w zakresie sprawozdawczości finansowej. Celem artykułu jest prezentacja wybranych obszarów rachunkowości instrumentów finansowych, które mogą być wyko- rzystane do kształtowania wyniku finansowego i sytuacji finansowej jednostki gospodarczej w kontek- ście pierwszego zastosowania tej regulacji. W artykule zastosowano metodę krytycznej analizy, wnio- skowania dedukcyjnego oraz studium przypadku. Na potrzeby artykułu i zastosowania studium przypad- ku przeprowadzono dwa wywiady niestrukturyzowane z osobami zajmującymi kierownicze stanowiska w instytucji finansowej w Polsce oraz przeanalizowano przeprowadzone przez nich symulacje.

  11. Testy czynnoœci płuc i nadreaktywnoœæ oskrzeli w astmie

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    Iwona Grzelewska-Rzymowska

    2009-09-01

    Full Text Available Astma jest chorobą, która charakteryzuje się odwracalną obturacją oskrzeli i postępującym spadkiem wskaźników wentylacji. Podstawową rolę w rozpoznawaniu astmy odgrywają badania spirometryczne z oznaczeniem podstawowych wartości natężonej pojemności życiowej (FVC i natężonej objętości wydechowej 1-sekundowej (FEV1 oraz wynikiem testu odwracalności obturacji oskrzeli. W monitorowaniu przebiegu astmy zaleca się oznaczanie wskaźnika określanego jako szczytowy przepływ wydechowy (PEF, jednak jego czułość jest mniejsza niż wskaźnika FEV1. Fundamentalną cechą astmy jest nadreaktywność oskrzeli, która wskazuje na większy stopień odpowiedzi oskrzeli osób chorych niż zdrowych. Nadreaktywność oskrzeli można określić, stosując wziewne testy prowokacyjne z bronchospastycznymi substancjami (histaminą, metacholiną, 5-AMP. U dzieci bardzo użyteczny jest test wysiłkowy, który charakteryzuje się dużą swoistością, ale małą czułością. Leczenie astmy poprawia jej kliniczny przebieg, jak również wskaźniki wentylacji, które pozwalają określić także stopień zaawansowania choroby. U chorych z przebudową oskrzeli nie obserwuje się wzrostu wskaźników wentylacji. Przebudowa oskrzeli powoduje nieodwracalną obturację i jest typowa dla chorych o ciężkim przebiegu tej choroby. W ciężkiej astmie ujemny wynik daje też test odwracalności obturacji oskrzeli, podobnie uzyskuje się niskie wartości PEF. Nadreaktywność oskrzeli jest użyteczna w procesie diagnozowania astmy. Jej wartość łączy się z zapaleniem alergicznym oskrzeli oraz wskaźnikami wentylacji. Leczenie poprawia przebieg kliniczny choroby i wskaźniki wentylacji, jednak nie wpływa na nadreaktywność oskrzeli.

  12. Estudos cognitivos em ciência da informaçãoCognitive studies in information science

    Directory of Open Access Journals (Sweden)

    Gercina Ângela Borem de Oliveira Lima

    2003-05-01

    Full Text Available The study of the influences from Cognitive Sciences in the information Science. The Information Science has as objects of study the very basic concepts of information and knowledge. Since such concepts have an inherently trans-disciplinary character, the Information Science has been largely influenced by many disciplines, particularly the Cognitive Science. Regardless of this, it is observed that such concepts have not been properly discussed within the Information Science. To deal with this concern, it has been structured in the Escola de Ciência da Informação (ECI of the Universidade Federal de Minas Gerais (UFMG, a research group denoted “Cognitive Studies in Information Science”. This work aims to discuss the relationships between the Information Science and the Cognitive Science. In order to achieve this purpose, one formerly presents the major approaches within the Cognitive Science, contextualizing their aspects that mostly influence the Information Science, and then one discuss some perspectives for the future relationship of these two disciplines.O estudo da influência das Ciências Cognitivas na Ciência da Informação. A Ciência da Informação, que tem como objetos de estudo a informação e o conhecimento, discute-os sob vários pontos de vista, sendo um deles, o cognitivo. Observa-se que os conceitos não têm sido adequadamente discutidos à luz das Ciências Cognitivas, apesar da Ciência da Informação sofrer muitas influências daquela disciplina. Em função dessas questões, estruturou-se, na Escola de Ciência da Informação–ECI da Universidade Federal de Minas Gerais-UFMG, o Grupo de Pesquisa “Estudos Cognitivos em Ciência da Informação” – GECCI. Neste trabalho, marco inicial das discussões do grupo, tem-se o objetivo de discutir as relações da Ciência da Informação com as Ciências Cognitivas. Para melhor compreensão desse relacionamento, serão apresentadas as principais vertentes das ci

  13. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Directory of Open Access Journals (Sweden)

    Xingsheng Hu

    Full Text Available Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC previously treated with platinum-based chemotherapy.Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day. The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety.From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m and 5.4 months (95%CI 3.1-7.9 m, respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127, diarrhea (12.6%, 16/127 and elevation of transaminase (15.7%, 20/127.In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy.ClinicalTrials.gov NCT02486354.

  14. VELoCiRaPTORS.

    Science.gov (United States)

    Lundgren, J.; Esham, B.; Padalino, S. J.; Sangster, T. C.; Glebov, V.

    2007-11-01

    The Venting and Exhausting of Low Level Air Contaminants in the Rapid Pneumatic Transport of Radioactive Samples (VELoCiRaPTORS) system is constructed to transport radioactive materials quickly and safely at the NIF. A radioactive sample will be placed inside a carrier that is transported via an airflow system produced by controlled differential pressure. Midway through the transportation process, the carrier will be stopped and vented by a powered exhaust blower which will remove radioactive gases within the transport carrier. A Geiger counter will monitor the activity of the exhaust gas to ensure that it is below acceptable levels. If the radiation level is sufficient, the carrier will pass through the remainder of the system, pneumatically braking at the counting station. The complete design will run manually or automatically with control software. Tests were performed using an inactive carrier to determine possible transportation problems. The system underwent many consecutive trials without failure. VELoCiRaPTORS is a prototype of a system that could be installed at both the Laboratory for Laser Energetics at the University of Rochester and the National Ignition Facility at LLNL.

  15. Aktywność fizyczna w terapii otyłości

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    Joanna Zapolska

    2009-03-01

    Full Text Available Otyłość jest chorobą określaną jako patologiczne zwiększenie ilości tkanki tłuszczowej, która w nadmiernej ilości wpływa negatywnie na stan zdrowia, długość życia i sprawność psychofizyczną. Osoby z nadmierną masą ciała, w której zawartość tłuszczu stanowi proporcjonalnie wysoki odsetek, w porównaniu z osobami o niższej masie ciała są fizjologicznie mniej wydolni, a ich potencjał motoryczny jest niższy. W otyłości u osób dorosłych dochodzi przede wszystkim do zwiększenia rozmiarów komórek tłuszczowych. W przypadku dzieci obserwujemy przyrost liczby komórek tłuszczowych, które mogą się przyczynić do rozwoju otyłości w wieku dorosłym, gdyż zwiększenie liczby komórek jest procesem nieodwracalnym. Często rodzice aż do momentu wystąpienia znacznej otyłości nie postrzegają nadmiernej masy ciała dziecka w kategoriach problemu zdrowotnego. Istotna staje się więc rola służby zdrowia w prowadzeniu działań prewencyjnych, skierowanych na działania np. fitness clubów odpowiednio przygotowanych do podejmowania tego typu zadań. Ogólnie przyjęte zasady dawkowania ćwiczeń w treningu zdrowotnym fitness osób dorosłych oraz dzieci i młodzieży są podobne. Różnią się czasem trwania, częstotliwością podejmowania aktywności oraz stosowanymi obciążeniami. Treningi fitness obejmują głównie wytrzymałościowe formy ćwiczeń, takie jak ćwiczenia aerobowe na urządzeniach typu cardio mające za zadanie przede wszystkim uaktywnić i zredukować nadmiar tkanki tłuszczowej. Inną formą zajęć usprawniających powinny być ćwiczenia oporowe uwzględniające stosowanie urządzeń izotonicznych. Należy przy tym zwrócić szczególną uwagę na dobór ćwiczeń, obciążenie oraz kontrolę postępów. Równocześnie zaleca się stosowanie monitoringu zakresów HR każdej sesji treningu aerobowego i oporowego. Jako uzupełnienie proponowane są ćwiczenia gibkościowe wykonywane jako

  16. Determination of drug, excipients and coating distribution in pharmaceutical tablets using NIR-CI

    Directory of Open Access Journals (Sweden)

    Anna Palou

    2012-04-01

    Full Text Available The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition. In this work, the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained. In addition, the same NIR-CI allowed the coating thickness and its surface distribution to be quantified. Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS algorithms. The concentrations of Active Pharmaceutical Ingredient (API and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation. But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. Keywords: Near infrared Chemical Imaging (NIR-CI, Hyperspectral imaging, Component distribution, Tablet coating distribution, Partial Least Squares (PLS regression

  17. Evaluation of the Clinical Data Dictionary (CiDD)

    Science.gov (United States)

    Lee, Myung Kyung; Min, Yul Ha; Kim, Younglan; Min, Hyo Ki; Ham, Sung Woo

    2010-01-01

    Objectives The purpose of the study was to evaluate content coverage and data quality of the Clinical Data Dictionary (CiDD) developed by the Center for Interoperable EHR (CiEHR). Methods A total of 12,994 terms were collected from 98 clinical forms of a tertiary cancer center hospital with 500 beds. After data cleaning, 9,418 terms were mapped with the data items of the CiDD by the research team, and validated by 30 doctors and nurses at the research hospital. Results Mapping results were classified into five categories: lexically mapped; semantically mapped; mapped to either a broader term or a narrower term; mapped to more than one term and not mapped. In terms of coverage, out of 9,418 terms, 6,750 (71.7%) terms were mapped; 4,319 (45.9%) terms were lexically mapped; 2,431 (25.8%) were semantically mapped; 281 (3.0%) terms were mapped to a broader term; 43 (0.5%) were mapped to a narrower term; and 550 (5.8%) were mapped to more than one term. In terms of data quality, the CiDD has problems such as errors in concept namingand representation, redundancy in synonyms, inadequate synonyms, and ambiguity in meaning. Conclusions Although the CiDD has terms covering 72% of local clinical terms, the CiDD can be improved by cleaning up errors and redundancies, adding textual definitions or use cases of the concept, and arranging the concepts in a hierarchy. PMID:21818428

  18. Korzyści karmienia piersią dla matki

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    Magdalena Gibas-Dorna

    2012-12-01

    Full Text Available Powszechnie wiadomo, że karmienie piersią pozytywnie wpływa na zdrowie dziecka oraz jego rozwój intelek‑ tualny. światowa Organizacja Zdrowia (World Health Organization, WHO zaleca rozpoczęcie karmienia piersią od pierwszej godziny po porodzie i jego kontynuację przez okres co najmniej 6 miesięcy, a w miarę urozmaicania diety dziecka rekomenduje utrzymanie tego sposobu żywienia mniej więcej do 2. roku życia, traktując mleko matki jako najlepszy jakościowo pokarm uzupełniający. Coraz częściej podkreśla się protek‑ cyjną rolę karmienia naturalnego w rozwoju różnych chorób u matek oraz potencjalne skutki unikania prze‑ dłużonej laktacji. Wydaje się, że korzyści dla matki mają charakter wczesny (podczas połogu oraz długofa‑ lowy. Tuż po porodzie karmienie piersią przyspiesza obkurczanie macicy, zapobiega nadmiernej utracie krwi, chroni przed niedokrwistością z niedoboru żelaza, przeciwdziała wystąpieniu depresji poporodowej, umacnia więź matka – dziecko oraz poprawia zaburzoną w tym okresie jakość snu. Korzyści długofalowe wiążą się z obniżeniem ryzyka wystąpienia niektórych chorób nowotworowych (rak sutka, rak endometrium, rak jajni‑ ka, chorób sercowo‑naczyniowych (choroba niedokrwienna serca, nadciśnienie tętnicze, zaburzeń metabo‑ licznych (cukrzyca, nietolerancja glukozy, otyłość, hiperlipidemia, hiperinsulinemia, reumatoidalnego zapa‑ lenia stawów czy osteoporozy. Przedłużenie okresu laktacji i karmienia piersią ma również wymierną korzyść ekonomiczną i stanowi darmową naturalną antykoncepcję. Poniższa praca podsumowuje aktualny stan wie‑ dzy na temat wpływu karmienia piersią na zdrowie matek karmiących.

  19. A crítica de Charles Taylor ao naturalismo na Ciência Política

    Directory of Open Access Journals (Sweden)

    Tiago Losso

    2011-06-01

    Full Text Available Os mais recentes esforços de revitalização do enfoque interpretativo na Ciência Política têm sua gênese na década de 1960, quando vários autores passaram a advogar a centralidade do estudo dos significados lingüístico e hermenêutico dos fenômenos políticos. Dentre tais autores, destaca-se o filósofo e politólogo Charles Taylor, cujos textos dos anos 1960 e 1970 desferem críticas contundentes ao naturalismo subjacente ao mainstream da Ciência Política da época. Meu objetivo é explorar a crítica de Taylor ao naturalismo, pensadas no contexto de uma proposta de abordagem interpretativa para a Ciência Política. Primeiramente, contextualizarei as contribuições de Taylor no âmbito mais amplo do interpretive turn nas Ciências Sociais. Em seguida, sumarizarei as reservas que Quentin Skinner e Clifford Geertz apresentam à crítica de Taylor.

  20. BADANIE MIESZANEK MINERALNO-ASFALTOWYCH W WARUNKACH ŚCINANIA PRZY KONTROLOWANEJ SZTYWNOŚCI WZDŁUŻNEJ

    Directory of Open Access Journals (Sweden)

    Adam ZOFKA

    2016-07-01

    Full Text Available W artykule przedstawiono koncepcję nowej metody badania próbek z mieszanki mineralno-asfaltowej w warunkach ścinania z ciśnieniem bocznym. Dotychczas stosowane metody badawcze ścinania z obciążeniem bocznym opierają się na ocenie właściwości mieszanki mineralno-asfaltowej przy ścinaniu w warunkach stałej siły wzdłużnej lub stałej objętości badanej próbki. Nowa metoda badawcza pozwala na badanie ścinania przy stałej sztywności wzdłużnej. Aby możliwe było badanie według tej metody, zaprojektowano i wykonano specjalną przystawkę o nazwie AST (ang. Advanced Shear Tester. W artykule przedstawiono zarówno opis procesu twórczego podczas projektowania przystawki, jak wykonane urządzenie. Zaprezentowano pierwsze wyniki badań walidacyjnych uzyskanych przy użyciu przystawki na próbkach UHMW-PE oraz z mieszanki mineralno-asfaltowej.

  1. Rola aktywności ruchowej w zapobieganiu zaburzeniom poznawczym

    Directory of Open Access Journals (Sweden)

    Andrzej W. Ziemba

    2014-11-01

    Full Text Available Regularna aktywność ruchowa wywołuje szereg zmian adaptacyjnych, zwłaszcza w układzie krążenia i przemianie materii. W licznych pracach na temat pojedynczego wysiłku i wzmożonej aktywności fizycznej pojawia się coraz więcej potwierdzeń ich korzystnego wpływu na kształtowanie funkcji poznawczych. U podstaw mechanizmów związanych z tym wpływem leżą zmiany anatomiczne i funkcjonalne, m.in. zwiększenie przepływu krwi przez mózg, angiogenezy i neurogenezy, objętości istoty szarej w korze czołowej i skroniowej. Wysiłek pobudza wydzielanie czynników troficznych, wśród których dla procesów poznawczych, plastyczności synaptycznej, poprawy szlaków sygnałowych neurogenezy i funkcji naczyniowych kluczowe są czynnik troficzny pochodzenia mózgowego i insulinopodobny czynnik wzrostowy. Aktywność ruchowa wywołuje wzmożoną ekspresję czynnika troficznego pochodzenia mózgowego, co pozytywnie wpływa na procesy energetyczne i aktywuje w mózgu wiele układów energetycznych, które korzystnie modyfikują potencjał synaptyczny przetwarzania informacji ważnych w kształtowaniu funkcji poznawczych. Wysiłek redukuje stan zapalny przez obniżenie we krwi stężenia cytokin prozapalnych, mogących się przyczyniać do rozwoju procesów neurodegeneracyjnych. Redukuje czynniki ryzyka zespołu metabolicznego, a zwłaszcza nadciśnienie i insulinooporność, więc zmniejsza ryzyko wystąpienia zaburzeń czynności poznawczych, poprawia funkcjonowanie mózgu, opóźnia początek i spowalnia rozwój zaburzeń w chorobach neurodegeneracyjnych, a wśród nich w chorobie Alzheimera i chorobie Parkinsona. Za sprawą wymienionych mechanizmów aktywność ruchowa wydaje się niezbędna do zachowania prawidłowych funkcji poznawczych w każdym wieku.

  2. Narrativas históricas: gravidade, sistemas de mundo e natureza da ciência

    Directory of Open Access Journals (Sweden)

    Juliana M. Hidalgo F. Drummond

    2015-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n1p99 De acordo com o entendimento de que o ensinar ciência e o ensinar sobre a ciência não devem estar dissociados, apresenta-se um conjunto de narrativas históricas para utilização no Ensino Médio, tecendo considerações sobre os recortes históricos procedidos e as escolhas implementadas em sua elaboração. Procura-se chamar a atenção para as potencialidades, possibilidades e limitações das narrativas. Esses pontos remetem explicitamente a reflexões relacionadas a uma utilização flexível, tendo em vista particularidades dos contextos educacionais.

  3.  Znaczenie dorobku naukowego Profesor Elżbiety Burzym dla rozwoju nauki i praktyki rachunkowości w Polsce

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    Irena Sobańska

    2014-04-01

    Full Text Available  Celem artykułu jest przypomnienie znaczenia dorobku naukowego Profesor Elżbiety Burzym dla rozwo-ju teorii rachunkowości, badań naukowych w tej dyscyplinie oraz praktyki rachunkowości w Polsce. Przedmiotem artykułu są definicje, tezy, poglądy i koncepcje teoretyczne systemu rachunkowości oraz systemu rachunku kosztów formułowane przez Profesor Burzym, które stanowią znaczący wkład w rozwój teorii rachunkowości w Polsce. W artykule objaśniono na przykładzie z literatury skutki roz-wiązywania problemów rachunkowości z perspektywy proceduralno-formalnej, a nie merytorycznej, która dominowała w opracowaniach naukowych Profesor Burzym.

  4. 21 CFR 73.3112 - C.I. Vat Orange 1.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The color additive is C.I. Vat Orange 1, Colour Index No. 59105. (b) Uses and restrictions. (1) The...

  5. Teologia, Ciência da Religião e Filosofia da Religião: definindo suas relações

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    Dierken, Jörg

    2009-01-01

    Full Text Available Trata-se de revisitar o complexo fenômeno da religião, à luz das articulações e diferenciações entre teologia, filosofia da religião e ciência da religião, particularmente no contexto sociocultural da modernidade e suas categorias iluministas de racionalidade, liberdade e ciência, em grandes pensadores tais como Max Weber e Ernst Troeltsch

  6. Kriegsbeute-Ausstellung Posen 1917. Propagandowa wystawa dla szerokiej publiczności

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    Jakub Skutecki

    2014-01-01

    Full Text Available W zbiorach ikonograficznych Biblioteki Uniwersyteckiej w Poznaniu znajduje się seria widokówek dokumentujących zorganizowaną w 1917 roku Wystawę Zdobyczy Wojennych (Kriegsbeute-Ausstellung Posen 1917, jedną z serii propagandowych ekspozycji prezentujących sukcesy armii niemieckich na wszystkich frontach wielkiej wojny. W czasie trwania wystawy w pobliżu belgijskiego Passchendaele toczyła się jedna z najkrwawszych bitew, a w Poznaniu – codzienne życie w wojennej rzeczywistości.

  7. Current status of the Citrus leprosis virus (CiLV -C and its vector Brevipalpus phoenicis (Geijskes

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    Guillermo León M

    2012-08-01

    Full Text Available The Citrus leprosis virus CiLV-C is a quarantine disease of economic importance. Over the past 15 years, this disease has spread to several countries of Central and South America. Colombia has about 45,000 hectares of citrus planted with an annual production of 750,000 tonnes. The CiLV-C has only been detected in the departments of Meta, Casanare and recently Tolima. Meta has 4,300 hectares representing 10% of the national cultivated area, and Casanare, where CiLV-C appeared in 2004, has no more than 500 ha planted with citrus. The presence of the Citrus leprosis virus in Colombia could affect the international market for citrus, other crops and ornamental plants with the United States and other countries without the disease. The false spider mite Brevipalpus phoenicis (Geijskes (Acari: Tenuipalpidae is the main vector of the CiLV-C. Disease management is based on control programs of the vector and diminishing host plants. Chemical mite control is expensive, wasteful and generates resistance to different acaricides. This paper provides basic information on CiLV-C and its vector, advances in diagnosis and methods to control the disease and prevention of its spread

  8. A biotechnological project with a gamma radiation source of 100,000 Ci

    International Nuclear Information System (INIS)

    Lombardo, J.H.; Smolko, E.E.

    1990-01-01

    A project for the production of radiovaccines and other bio-medical products is presented which includes a radiation facility provided with a gamma ray source equivalent to 100,000 Ci of Co-60. The whole process incorporates novel basic features in virus production and inactivation steps. The former is carried out in animals previously subjected to immunodepression through electromagnetic radiation. The latter is obtained at low temperatures by using either electromagnetic or particle radiations. A vaccine manufacture process is shown to illustrate the utilization of ionizing radiations to obtain a foot and mouth disease virus (FMDV) vaccine with good antigenic quality and low cost. (author)

  9. O modelo de Karl Popper sob a ótica das Ciências Sociais Aplicadas

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    Milton de Abreu Campanario

    2012-04-01

    Full Text Available DOI: http://dx.doi.org/10.5007/2175-8077.2012v14n32p124 Karl Popper é o principal filósofo da ciência na modernidade, disputando com Thomas Kuhn a primazia de interpretação do método científico. Claramente há diferentes visões para uma leitura desse importante autor que cunhou o método chamado de dedutivo com teste. O texto reconhece a relevância da visão de Karl Popperno desenvolvimento de trabalhos científicos das ciências exatas e biológicas, onde é amplamente aceita. No entanto, nota-se que essa formulação é pouco sistematizada na área das ciências sociais aplicadas. Este é um ensaio que busca resgatar a sua contribuição, numa tentativa de traduzir os conceitos por ele desenvolvidos de forma didática. Para tanto, será feita uma introdução aos fundamentos da ciência como forma específica de conhecimento, buscando contrastar os métodos dedutivo e indutivo e os procedimentos da ciência formal, básica e aplicada. Uma tentativa de classificar a formulação de proposições a serem testadas ou falseadas é feita com a utilização de diferentes critérios, utilizando exemplos da administração e da economia para ilustração.

  10. Ética, ciência e tecnologia

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    Ivan Domingues

    2004-06-01

    Full Text Available O artigo visa pensar a relação entre ética, ciência e tecnologia, enfatizando o problema de sua revinculação depois da cisão entre os juízos de fato e os juízos de valor, ocorrida no início dos tempos modernos. Uma vez examinada a ética da aristocracia guerreira e a moral do santo, procura-se delinear o caminho tomando como referência a ética da responsabilidade, cujo protótipo é a moral do sábio, desaparecido no curso dos tempos modernos, em razão da fragmentação do saber e do advento do especialista. Ao fim do estudo, é discutida a relação entre a ética e a metafísica, com o intuito de ajustar a questão antropológica à perspectiva cosmológica, bem como de fornecer as bases de um novo humanismo, objetivando a humanização da técnica e a geração de um novo homem, alfabetizado em ciência, tecnologia e humanidades.The article aims at thinking the relation among ethics, science and technology, emphasizing the problem of their re-tying, after the division into judgments of fact and judgments of value, wich happened in the begininning of modern times. Since the warlike aristocracy's ethics and the saint man's moral are examined, it tries to outline its way, taking as a reference the ethics of responsability, whose prototype is the wise man's moral, which disappeared in the course of modern times, due to the fragmentation of knowing and the advent of the specialist. At the end of the study, the relationship between ethics and metaphysics is discussed, aiming at adjusting the anthropological question to the cosmological perspective, as well as at providing the bases of a new humanism, objectifying the humanization of the technique and the generation of a new man, literate at science, technology and the humanities.

  11. A SBPC e a informação ambiental no Brasil: o papel da revista Ciência Hoje

    Directory of Open Access Journals (Sweden)

    Antonio Teixeira De Barros

    Full Text Available Analisa u informação ambiental divulgada pela revista Ciência Hoje, editada pela Sociedade Brasileira para o Progresso da Ciência (SBPC, desde o primeiro número da revista até a realização da Eco 92. A divulgação concentra-se nos estudos de avaliação de impactos e efeitos da degradação ambiental e nos temas globais da agenda ecológica. O didatismo é uma das características principais de Ciência Ho je, com o intuito de facilitar a leitura por parte do público leigo.

  12. Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women

    Directory of Open Access Journals (Sweden)

    Katarzyna Urtnowska

    2016-05-01

    4Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy           mgr Katarzyna Urtnowska1, dr n. med. Irena Bułatowicz2, dr hab. n. med. Grzegorz Ludwikowski3, dr hab. Walery Zukow4 1Uczestnik studiów dokotranckich z zakresu Nauk o Zdrowiu; Zakład Medycyny Rozdrodu i Andrologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 2Katedra Fizjoterapii - Zakład Fizjoterapii Klinicznej, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 3Zakład Medycyny Rozdrodu i Andrologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 4Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy           Słowa kluczowe: ciąża, aktywność fizyczna, sport. Keywords: pregnancy, physical activity, sport.           Streszczenie Kobieta spodziewać się dziecka w dzisiejszych czasach ma wiele możliwości podjęcia bezpiecznej formy aktywności fizycznej. Z odrobiną racjonalnego podejścia może kontynuować uprawianie ulubionego sportu, lub uczestniczyć w zajęciach przygotowanych specjalnie dla ciężarnych. Aktywność fizyczna uprawiana regularnie w trakcie ciąży jest kluczowym czynnikiem wpływającym na zdrowie i samopoczucie matki. Ćwiczenia wpływają korzystnie na stan zdrowia poprzez zmniejszenie dolegliwości bólowych kręgosłupa, ogólną poprawę lub brak pogorszenia sprawności fizycznej, zapobieganie nadmiernemu przyrostowi masy ciała i poprawę samopoczucia ciężarnej. Dodatkowym, a zarazem najważniejszym efektem jest zwiększenie wydolności fizycznej niezbędnej do porodu siłami natury i skrócenie czasu jego przebiegu oraz czasu regeneracji organizmu w połogu, a co za tym idzie, szybszy powrót do formy sprzed ciąży.     Abstract A women expect a child a child today has a lot of possibilities for secure forms of physical activity. With

  13. The Relation between Nonverbal IQ and Postoperative CI Outcomes in Cochlear Implant Users: Preliminary Result

    Directory of Open Access Journals (Sweden)

    Mina Park

    2015-01-01

    Full Text Available Objectives. This study assessed the correlation between performance intelligence and the postoperative cochlear implant (CI outcome in Korean-speaking children. In addition, the relationship between the performance intelligence subscales and the post-CI speech outcome was evaluated. Materials and Methods. Thirteen pediatric CI users (five males, eight females; median age at implantation 6.2 (range 1.3–14.2 years; median age at intelligence test 9.3 (range 5–16 years who were tested using the Korean Educational Development Institute-Wechsler Intelligence Scale for children were studied. The correlations between the intelligence scores and 1-2 years postoperative Categories of Auditory Performance (CAP scores and between subscales of performance and 1-2 years postoperative CAP scores were analyzed. Results. There was no correlation between the categories of verbal intelligence quotient (IQ and performance IQ for “mentally retarded” and “average,” respectively (Spearman’s rho = 0.42, P=0.15. There was a strong correlation between performance IQ and the postoperative CAP scale (Spearman’s rho = 0.8977, P=0.0008. “Picture arrangement” and “picture completion,” reflecting social cognition, were strongly correlated with the postoperative CAP scales. Conclusion. Performance intelligence, especially social cognition, was strongly related to the postoperative CI outcome of cochlear implant users. Therefore, auditory rehabilitation, including social rehabilitation, should maximize the postoperative CI outcomes.

  14. The CI:Marketing interface

    OpenAIRE

    Wright, Sheila

    2005-01-01

    The potential for CI to inform and influence marketing decisions is increasing and this combination can deliver an enviable competitive advantage. Simply knowing more about competitors is not enough. It is what the firm does with that information and how it weaves it into its decision making process which makes the difference. In a large number of organisations, private or public, it is the Marketing Department which carries the responsibility for critical activities such as customer manageme...

  15. Antioxidant properties of selected culinary spices / Antyoksydacyjne właściwości wybranych przypraw

    Directory of Open Access Journals (Sweden)

    Słowianek Marta

    2016-03-01

    Full Text Available Wstęp: Przyprawy dodawane do żywności wzbogacają jej walory smakowe i zapachowe, niektóre z nich mogą także wydłużać jej czas przechowywania dzięki obecności związków o aktywności przeciwutleniającej. Cel: Celem pracy było zbadanie 28 przypraw dostępnych na rynku pod kątem całkowitej zawartości polifenoli i aktywności przeciwutleniającej. Metody: Do oceny całkowitej zawartości związków fenolowych zastosowano metodę Folina- Ciocalteau. Aktywność antyoksydacyjną ekstraktów oznaczono metodą z użyciem rodnika DPPH. Wyniki: Otrzymane wyniki wykazują, że większość analizowanych przypraw jest bogata w związki fenolowe i posiada wysoką aktywność antyoksydacyjną. Całkowita zawartość polifenoli w przyprawach oscylowała od 0,9 do 155,1 mg GAE/g z najniższą wartością odnotowaną dla sezamu i najwyższą dla cynamonu. Zdolność do wygaszania rodnika DPPH wyrażona w procentach była zróżnicowana i wahała się w zakresie od 4,1% dla sezamu do 94,9% dla goździków. Odnotowano umiarkowaną korelację (r=0,63, p<0,05 pomiędzy aktywnością antyoksydacyjną i zawartością polifenoli ogółem, co dowodzi, że związki fenolowe są ważnymi, antyoksydacyjnymi składnikami w badanych przyprawach. Wnioski: Prowadzone badania wykazują, że wiele przypraw może służyć jako naturalne konserwanty żywności i jednocześnie ma korzystny wpływ na nasze zdrowie.

  16. Klozapina: między skutecznością a bezpieczeństwem

    Directory of Open Access Journals (Sweden)

    Tomasz Sobów

    2015-07-01

    Full Text Available Klozapina, choć uważana za bardzo skuteczny lek przeciwpsychotyczny, jest stosowana rzadziej, niż wynikałoby z przesłanek klinicznych wspierających jej stosowanie. Co najmniej 1/3 chorych ze schizofrenią spełnia kliniczne kryteria lekooporności, charakteryzuje się wysokim ryzykiem samobójstwa lub reaguje nasilonymi objawami pozapiramidowymi na inne leki przeciwpsychotyczne. Możliwym powodem relatywnie rzadkiego sięgania po klozapinę w praktyce klinicznej jest postrzeganie leku jako obarczonego poważnymi objawami niepożądanymi. Agranulocytoza i inne dyskrazje krwi są dobrze znane, a zasady prewencji – uporządkowane zaleceniami. O innych objawach niepożądanych, również tych potencjalnie niebezpiecznych (kardiomiopatia, zapalenia mięśnia sercowego, niedrożność jelit czy drgawki wiadomo mniej. Ryzyko wystąpienia groźnych powikłań kuracji klozapiną można jednak zminimalizować, a same powikłania – wykrywać i leczyć, pod warunkiem zachowania czujności diagnostycznej. Świadomość ryzyka i korzyści związanych ze stosowaniem klozapiny to warunek konieczny skutecznego i bezpiecznego użycia tego leku oraz pełnego wykorzystania jego niezwykłych właściwości.

  17. O Museu de Ciência: espaço da história da ciência The Science Museum: a place of history of science

    Directory of Open Access Journals (Sweden)

    Maria Esther Alvarez Valente

    2005-04-01

    Full Text Available O artigo apresenta uma reflexão sobre o Museu de Ciência a partir de sua dimensão educativa. O que está em discussão é a abordagem sobre os temas científicos e a exploração dos objetos museológicos apresentados no sentido de facilitar o entendimento público da Ciência. Principalmente a partir da segunda metada do século XX, a comunicação nestes espaços, voltada para o público leigo, opta por estratégias que priorizam, quase exclusivamente, a apresentação de fenômenos científicos, construindo desta maneira saberes a-históricos. Com base na perspectiva da História da Ciência o esforço, hoje, é o de ampliar a interpretação dos temas e objetos, revelando a intangibilidade ligada a eles, e que compreendem o ato de criação científico, os processos de conhecimento da ciência e sua relação com o homem e a sociedade. Trata-se de uma abordagem que auxilia os indivíduos a dar significado aos conteúdos científicos.The article is bringsa reflection on the science museum focusinged on its educational dimension. The discussion is about the approach of the interpretation ofn scientific themes and objects, both presented in the museum's exhibitions, in order to promote the public's understanding of science. Starting mainly in the second half of the twentieth century, communication occurred in Science Museums and more precisely in Science Centres, with presentations focused, exclusively on the scientific phenomena. What results is a knowledge without historical foundations. Instead we propose another approach based on the history of science perspective. It opens up the interpretation ofn the intangible aspectsside of the objects as well asand the cold information. It emphasisesis the act of scientificce creation, the process of science knowledge and its relationship with man and society. The new approach will help people give significance to the scientific contents.

  18. Przyczynek do postrzegania struktury współczesnego systemu rachunkowości

    Directory of Open Access Journals (Sweden)

    Irena Sobańska

    2018-03-01

    Full Text Available Głównym celem artykułu jest objaśnienie procesu ewoluowania elementów systemu rachunkowości organizacji gospodarczej pod wpływem zmian zachodzących w różnicach informacji oczekiwanych przez odbiorców wewnętrznych i zewnętrznych. Dla zrealizowania tego celu przedstawiono zamęt regu- lacyjny w obszarze rachunkowości i jego skutki dla rozwoju systemów rachunkowości w praktyce w Polsce oraz przeanalizowano zmiany w potrzebach informacyjnych interesariuszy w kontekście wprowadzanych zmian w sprawozdaniach finansowych, zintegrowanych raportach biznesowych i zmian w stosowanych metodach rachunkowości zarządczej w organizacjach społecznie odpowiedzialnych. Następnie przedsta- wiona została autorska propozycja nowej struktury systemu rachunkowości odpowiadająca jego współczesnej funkcjonalności w warunkach obecnego poziomu rozwoju globalizacji, zmierzającego w kierun- ku zrównoważonej gospodarki oraz szereg wniosków ogólnych wynikających z przedstawionych rozwa- żań. W propozycji nowej struktury przyjęto, że system rachunkowości organizacji społecznie odpowie- dzialnej powinien być zbudowany z podsystemu rachunkowości biznesowej, emitującego zintegrowany raport biznesowy (sprawozdanie finansowe + raporty niefinansowe i wewnętrzne raporty dla zarządu oraz podsystemu rachunkowości podatkowej, emitującego informacje dla agend podatkowych. W opra- cowaniu artykułu zastosowano analizę treści i opinii autorów wybranych publikacji, metodę analizy dokumentów oraz wiedzę uzyskaną metodą obserwacji bezpośredniej i wyniki badań empirycznych innych autorów. The main goal of the article is to explain the process of evolution of the organization's accounting system elements as a result of changes taking place in information expected by internal and external users. To achieve this goal, regulatory uncertainties in the area of accounting and their consequences for the devel- opment of accounting systems in

  19. Rola otyłości w patogenezie chorób alergicznych

    Directory of Open Access Journals (Sweden)

    Anna Grad

    2009-09-01

    Full Text Available W ostatnich latach wzrosła zachorowalność na astmę i inne choroby alergiczne. Jednocześnie obserwuje się zwiększenie liczby pacjentów z nadmierną masą ciała i podwyższoną wartością wskaźnika wagowo-wzrostowego (BMI. Wydaje się, że mimo odmiennego patomechanizmu astmy i otyłości istnieje wspólne ogniwo patogenetyczne rozwoju tych chorób. Bierze się pod uwagę rolę czynników środowiskowych, dietetycznych, genetycznych i infekcyjnych. Wyniki większości badań epidemiologicznych potwierdzają związek nadwagi i otyłości z ryzykiem wystąpienia astmy zarówno u osób dorosłych, jak i u dzieci. Podkreśla się rolę wysokiej urodzeniowej masy ciała i większych przyrostów masy ciała w pierwszym roku życia. Natomiast występowanie alergicznego nieżytu nosa i alergicznego zapalenia spojówek koreluje ujemnie z masą ciała. Nie obserwowano związku otyłości z częstością występowania atopowego zapalenia skóry. Tkanka tłuszczowa jako narząd endokrynny produkuje dużo różnych cytokin, hormonów, czynników wzrostu. Jest źródłem czynników prozapalnych, między innymi IL-6, TNF-a, TGF-b, leptyny, rezystyny. Leptyna jest produkowana przez adipocyty, jej stężenie koreluje z masą tkanki tłuszczowej, może ona intensyfikować zapalenie oraz odgrywać ważną rolę w rozwoju płuc. Podwyższone stężenie leptyny w surowicy jest uważane za czynnik prognostyczny rozwoju astmy. Adiponektyna ma właściwości przeciwzapalne, jej stężenie maleje w otyłości i koreluje ujemnie ze wskaź- nikiem BMI. W rozwoju astmy u osób otyłych biorą również udział rezystyna, eotaksyna, białko aP2 oraz żeńskie hormony płciowe. Rola czynników genetycznych nie jest do końca poznana. Dotychczas wyodrębniono 4 regiony chromosomalne związane ze zwiększoną podatnością na zachorowanie na astmę i otyłość. Efekt ochronny mają czynniki dietetyczne, takie jak antyoksydanty i mikroelementy. Otyłość pogarsza

  20. Rola otyłości w patogenezie chorób alergicznych

    Directory of Open Access Journals (Sweden)

    Anna Grad

    2008-10-01

    Full Text Available W ostatnich latach wzrosła zachorowalność na astmę i inne choroby alergiczne. Jednocześnie obserwuje się zwiększenie liczby pacjentów z nadmierną masą ciała i podwyższoną wartością wskaźnika wagowo-wzrostowego (BMI. Wydaje się, że mimo odmiennego patomechanizmu astmy i otyłości istnieje wspólne ogniwo patogenetyczne rozwoju tych chorób. Bierze się pod uwagę rolę czynników środowiskowych, dietetycznych, genetycznych i infekcyjnych. Wyniki większości badań epidemiologicznych potwierdzają związek nadwagi i otyłości z ryzykiem wystąpienia astmy zarówno u osób dorosłych, jak i u dzieci. Podkreśla się rolę wysokiej urodzeniowej masy ciała i większych przyrostów masy ciała w pierwszym roku życia. Natomiast występowanie alergicznego nieżytu nosa i alergicznego zapalenia spojówek koreluje ujemnie z masą ciała. Nie obserwowano związku otyłości z częstością występowania atopowego zapalenia skóry. Tkanka tłuszczowa jako narząd endokrynny produkuje dużo różnych cytokin, hormonów, czynników wzrostu. Jest źródłem czynników prozapalnych, między innymi IL-6, TNF-a, TGF-b, leptyny, rezystyny. Leptyna jest produkowana przez adipocyty, jej stężenie koreluje z masą tkanki tłuszczowej, może ona intensyfikować zapalenie oraz odgrywać ważną rolę w rozwoju płuc. Podwyższone stężenie leptyny w surowicy jest uważane za czynnik prognostyczny rozwoju astmy. Adiponektyna ma właściwości przeciwzapalne, jej stężenie maleje w otyłości i koreluje ujemnie ze wskaź- nikiem BMI. W rozwoju astmy u osób otyłych biorą również udział rezystyna, eotaksyna, białko aP2 oraz żeń- skie hormony płciowe. Rola czynników genetycznych nie jest do końca poznana. Dotychczas wyodrębniono 4 regiony chromosomalne związane ze zwiększoną podatnością na zachorowanie na astmę i otyłość. Efekt ochronny mają czynniki dietetyczne, takie jak antyoksydanty i mikroelementy. Otyłość pogarsza

  1. Customer responses to mandatory menu labeling at full-service restaurants.

    Science.gov (United States)

    Auchincloss, Amy H; Mallya, Giridhar G; Leonberg, Beth L; Ricchezza, Andrew; Glanz, Karen; Schwarz, Donald F

    2013-12-01

    In 2010, Philadelphia enacted a menu-labeling law requiring full-service restaurant chains to list values for calories, sodium, fat, and carbohydrates for each item on all printed menus. The goal of the study was to determine whether purchase decisions at full-service restaurants varied depending on the presence of labeling. In August 2011, this cross-sectional study collected 648 customer surveys and transaction receipts at seven restaurant outlets of one large full-service restaurant chain. Two outlets had menu labeling (case sites); five outlets did not (control sites). Outcomes included differences in calories and nutrients purchased and customers' reported use of nutrition information when ordering. Data were analyzed in 2012. Mean age was 37 years; 60% were female; 50% were black/African-American and reported incomes ≥$60,000. Customers purchased food with approximately 1600 kcal (food plus beverage, 1800 kcal); 3200 mg sodium; and 35 g saturated fat. After adjustment for confounders, customers at labeled restaurants purchased food with 151 fewer kilocalories (95% CI=-270, -33); 224 mg less sodium (95% CI=-457, +8); and 3.7 g less saturated fat (95% CI=-7.4, -0.1) compared to customers at unlabeled restaurants (or 155 less kilocalories from food plus beverage, 95% CI=-284, -27). Those reporting that nutrition information affected their order purchased 400 fewer food calories, 370 mg less sodium, and 10 g less saturated fat. Mandatory menu labeling was associated with better food choices among a segment of the public dining at full-service restaurants. Consumer education on the availability and use of nutrition information may extend the impact of menu labeling. © 2013 American Journal of Preventive Medicine Published by American Journal of Preventive Medicine All rights reserved.

  2. Badania wartości ekonomicznej usług biblioteczno-informacyjnych i ich wpływu na otoczenie

    Directory of Open Access Journals (Sweden)

    Ewa Głowacka

    2011-01-01

    Full Text Available Biblioteki pełnią różnorodne funkcje we współczesnym otoczeniu społecznym. Uczestniczą w tworzeniu kapitału intelektualnego i społecznego, wpływają na wzrost korzyści ekonomicznych użytkowników i całego społeczeństwa. W artykule omówiono główne podejścia i metody badawcze w zakresie oceny korzyści ekonomicznych płynących z funkcjonowania bibliotek. Skupiono się na metodzie analizy kosztów w stosunku do korzyści (ang. CBA – cost-benefit analysis, metodzie analizy warunkowej (ang. CVM – contigent valuation method, określaniu wartości dodanej dla użytkownika (ang. consumer surplus method i metodologii oceny stopy wzrostu z inwestycji (ang. ROI – return of investment. Przeanalizowano również różne projekty badań prowadzone na świecie w tym zakresie.

  3. Evaluation of a rapid dipstick (Crystal VC for the diagnosis of cholera in Zanzibar and a comparison with previous studies.

    Directory of Open Access Journals (Sweden)

    Benedikt Ley

    Full Text Available The gold standard for the diagnosis of cholera is stool culture, but this requires laboratory facilities and takes at least 24 hours. A rapid diagnostic test (RDT that can be used by minimally trained staff at treatment centers could potentially improve the reporting and management of cholera outbreaks.We evaluated the Crystal VC™ RDT under field conditions in Zanzibar in 2009. Patients presenting to treatment centers with watery diarrhea provided a stool sample for rapid diagnostic testing. Results were compared to stool culture performed in a reference laboratory. We assessed the overall performance of the RDT and evaluated whether previous intake of antibiotics, intravenous fluids, location of testing, and skill level of the technician affected the RDT results.We included stool samples from 624 patients. Compared to culture, the overall sensitivity of the RDT was 93.1% (95%CI: 88.7 to 96.2%, specificity was 49.2% (95%CI: 44.3 to 54.1%, the positive predictive value was 47.0% (95%CI: 42.1 to 52.0% and the negative predictive value was 93.6% (95%CI: 89.6 to 96.5%. The overall false positivity rate was 50.8% (213/419; fieldworkers frequently misread very faint test lines as positive.The observed sensitivity of the Crystal VC RDT evaluated was similar compared to earlier versions, while specificity was poorer. The current version of the RDT could potentially be used as a screening tool in the field. Because of the high proportion of false positive results when field workers test stool specimens, positive results will need to be confirmed with stool culture.

  4. Complex coordinate rotation and relativistic Hylleraas-CI: helium isoelectronic series

    International Nuclear Information System (INIS)

    Pestka, G; Bylicki, M; Karwowski, J

    2007-01-01

    A combination of the Hylleraas-CI (Hy-CI) and complex coordinate rotation (CCR) methods has been applied to study the nuclear charge dependence of the eigenvalues of the Dirac-Coulomb (DC) Hamiltonian corresponding to the ground states of helium isoelectronic series atoms. It has been shown that the CCR, due to the separation of the localized states from the unphysical Brown-Ravenhall continuum, removes the instabilities of the bound-state eigenvalues observed in large-basis set Hy-CI results. The Hy-CI-CCR results are in very good agreement with the most accurate ones available in the literature. Surprisingly, the difference between the DC Hy-CI-CCR eigenvalues and the eigenvalues of the positive-energy projected no-pair Hamiltonian is equal, up to the numerical accuracy of the results, to (Zα) 3 /6π, i.e. to (Zα) 3 relativistic many-body perturbation theory contribution for electron-electron Coulomb interaction operator. An excellent agreement between the Hy-CI-CCR eigenvalues shifted by (Zα) 3 /6π and the no-pair ones confirms the very high accuracy achieved in both approaches. The numerical accuracy of the Hy-CI-CCR DC eigenvalues is estimated to eight significant figures

  5. The maternal genes Ci-p53/p73-a and Ci-p53/p73-b regulate zygotic ZicL expression and notochord differentiation in Ciona intestinalis embryos.

    Science.gov (United States)

    Noda, Takeshi

    2011-12-01

    I isolated a Ciona intestinalis homolog of p53, Ci-p53/p73-a, in a microarray screen of rapidly degraded maternal mRNA by comparing the transcriptomes of unfertilized eggs and 32-cell stage embryos. Higher expression of the gene in eggs and lower expression in later embryonic stages were confirmed by whole-mount in situ hybridization (WISH) and quantitative reverse transcription-PCR (qRT-PCR); expression was ubiquitous in eggs and early embryos. Knockdown of Ci-p53/p73-a by injection of antisense morpholino oligonucleotides (MOs) severely perturbed gastrulation cell movements and expression of notochord marker genes. A key regulator of notochord differentiation in Ciona embryos is Brachyury (Ci-Bra), which is directly activated by a zic-like gene (Ci-ZicL). The expression of Ci-ZicL and Ci-Bra in A-line notochord precursors was downregulated in Ci-p53/p73-a knockdown embryos. Maternal expression of Ci-p53/p73-b, a homolog of Ci-p53/p73-a, was also detected. In Ci-p53/p73-b knockdown embryos, gastrulation cell movements, expression of Ci-ZicL and Ci-Bra in A-line notochord precursors, and expression of notochord marker gene at later stages were perturbed. The upstream region of Ci-ZicL contains putative p53-binding sites. Cis-regulatory analysis of Ci-ZicL showed that these sites are involved in expression of Ci-ZicL in A-line notochord precursors at the 32-cell and early gastrula stages. These results suggest that p53 genes are maternal factors that play a crucial role in A-line notochord differentiation in C. intestinalis embryos by regulating Ci-ZicL expression. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

    Directory of Open Access Journals (Sweden)

    Rafael Almeida-Reis

    2017-01-01

    Full Text Available Background. Proteinases play a key role in emphysema. Bauhinia bauhinioides cruzipain inhibitor (BbCI is a serine-cysteine proteinase inhibitor. We evaluated BbCI treatment in elastase-induced pulmonary alterations. Methods.  C57BL/6 mice received intratracheal elastase (ELA group or saline (SAL group. One group of mice was treated with BbCI (days 1, 15, and 21 after elastase instillation, ELABC group. Controls received saline and BbCI (SALBC group. After 28 days, we evaluated respiratory mechanics, exhaled nitric oxide, and bronchoalveolar lavage fluid. In lung tissue we measured airspace enlargement, quantified neutrophils, TNFα-, MMP-9-, MMP-12-, TIMP-1-, iNOS-, and eNOS-positive cells, 8-iso-PGF2α, collagen, and elastic fibers in alveolar septa and airways. MUC-5-positive cells were quantified only in airways. Results. BbCI reduced elastase-induced changes in pulmonary mechanics, airspace enlargement and elastase-induced increases in total cells, and neutrophils in BALF. BbCI reduced macrophages and neutrophils positive cells in alveolar septa and neutrophils and TNFα-positive cells in airways. BbCI attenuated elastic and collagen fibers, MMP-9- and MMP-12-positive cells, and isoprostane and iNOS-positive cells in alveolar septa and airways. BbCI reduced MUC5ac-positive cells in airways. Conclusions. BbCI improved lung mechanics and reduced lung inflammation and airspace enlargement and increased oxidative stress levels induced by elastase. BbCI may have therapeutic potential in chronic obstructive pulmonary disease.

  7. A ideia de ciência em Karl Marx

    Directory of Open Access Journals (Sweden)

    Ricardo Luís Chaves Feijó

    2015-12-01

    ideias: a economia política clássica e o legado alemão. Em seguida, investiga-se o que seria a sua concepção particular de ciência, entendida como uma proposta de fundir esses dois legados. Avalia-se, em seguida, o caráter científico da contribuição marxiana, entendida como o fazer de uma ciência que se propõe positiva. Destarte, iremos examinar as razões que separam a tradição marxiana e o mainstream da economia atual, mostrando que a natureza peculiar de uma ciência de raízes alemãs gera dificuldades na comunicação entre uma e outra.

  8. Application of the graphical unitary group approach to the energy second derivative for CI wave functions via the coupled perturbed CI equations

    International Nuclear Information System (INIS)

    Fox, D.J.

    1983-10-01

    Analytic derivatives of the potential energy for Self-Consistent-Field (SCF) wave functions have been developed in recent years and found to be useful tools. The first derivative for configuration interaction (CI) wave functions is also available. This work details the extension of analytic methods to energy second derivatives for CI wave functions. The principal extension required for second derivatives is evaluation of the first order change in the CI wave function with respect to a nuclear perturbation. The shape driven graphical unitary group approach (SDGUGA) direct CI program was adapted to evaluate this term via the coupled-perturbed CI equations. Several iterative schemes are compared for use in solving these equations. The pilot program makes no use of molecular symmetry but the timing results show that utilization of molecular symmetry is desirable. The principles for defining and solving a set of symmetry adapted equations are discussed. Evaluation of the second derivative also requires the solution of the second order coupled-perturbed Hartree-Fock equations to obtain the correction to the molecular orbitals due to the nuclear perturbation. This process takes a consistently higher percentage of the computation time than for the first order equations alone and a strategy for its reduction is discussed

  9. Combustion Stratification for Naphtha from CI Combustion to PPC

    KAUST Repository

    Vallinayagam, R.; Vedharaj, S.; An, Yanzhao; Dawood, Alaaeldin; Izadi Najafabadi, Mohammad; Somers, Bart; Johansson, Bengt

    2017-01-01

    This study demonstrates the combustion stratification from conventional compression ignition (CI) combustion to partially premixed combustion (PPC). Experiments are performed in an optical CI engine at a speed of 1200 rpm for diesel and naphtha (RON

  10. Predictors of full-time faculty appointment among MD–PhD program graduates: a national cohort study

    Directory of Open Access Journals (Sweden)

    Dorothy A. Andriole

    2016-05-01

    Full Text Available Purpose: The authors sought to identify variables associated with MD–PhD program graduates’ academic medicine careers. Methods: We analyzed data for a national cohort of MD–PhD program graduates from 2000 to 2005, using multivariable logistic regression to identify independent predictors of full-time academic medicine faculty appointment through 2013. Results: Of 1,860 MD–PhD program graduates in 2000–2005, we included 1,846 (99.2% who had completed residency training before 2014. Of these 1,846 graduates, 968 (52.4% held full-time faculty appointments. Graduates who attended schools with Medical Scientist Training Program (MSTP funding (vs. no MSTP funding; adjusted odds ratio [aOR], 1.41; 95% confidence interval [CI], 1.14–1.74 and participated in ≥1 year of research during residency (vs. no documented research year; aOR, 1.85; 95% CI, 1.50–2.28 were more likely to have held full-time faculty appointments. Asian/Pacific Islander (aOR, 0.74; 95% CI, 0.60–0.93 and under-represented minority (URM; aOR, 0.68; 95% CI, 0.48–0.98 graduates (each vs. white graduates, graduates who reported total debt of ≥$100,000 (vs. no debt at graduation (aOR, 0.58; 95% CI, 0.39–0.88, and graduates in surgical practice (aOR, 0.64; 95% CI, 0.48–0.84 and other practice (aOR, 0.66, 95% CI, 0.54–0.81 specialties (each vs. ‘medicine, pediatrics, pathology, or neurology’ were less likely to have held full-time faculty appointments. Gender was not independently associated with likelihood of full-time faculty appointment. Conclusions: Over half of all MD–PhD program graduates in our study had full-time faculty appointments. Our findings regarding variables independently associated with full-time faculty appointments can inform the design of strategies to promote academic medicine career choice among MD–PhD program graduates. Further research is warranted to identify other factors amenable to intervention, in addition to those included in

  11. Aulas de ciências para surdos: estudos sobre a produção do discurso de intérpretes de LIBRAS e professores de ciências

    Directory of Open Access Journals (Sweden)

    Walquíria Dutra de Oliveira

    2015-06-01

    Full Text Available O bilinguismo na educação de surdos pressupõe a língua de sinais como primeira língua do surdo e, com a inclusão escolar, os alunos surdos foram inseridos em instituições regulares de ensino, implicando uma nova estrutura da sala de aula. O ensino de ciências para surdos é um desafio, pois o aluno surdo utiliza uma língua diferente da do professor, e necessita de um intérprete de LIBRAS para ter acesso ao corpo de conhecimentos mediados por ele. A investigação objetivou analisar a produção de narrativas (um gênero do discurso de professores e intérpretes de LIBRAS sobre a aula de ciências para surdos. As narrativas foram produzidas no “diário de aula”, e foram analisadas pela técnica de análise de conteúdo. Nossos resultados apontam que o bilinguismo ainda não permeia a sala de aula inclusiva, e que a barreira linguística é a maior dificuldade encontrada no aprendizado dos conhecimentos científicos pelos alunos surdos.

  12. Development and Analysis of Original UNIFAC-CI and Modified UNIFAC-CI Models for Prediction of VLE and SLE Systems

    DEFF Research Database (Denmark)

    Mustaffa, Azizul Azri; Kontogeorgis, Georgios; Kang, Jeong Won

    approach that is able to extend the application range of property models has been developed for mixture properties. This so-called GCPlus approach is a hybrid model which combines GC and valence connectivity indices (CI). The main idea is the use of CI to describe the molecular fragmentation that relates...... parameters are checked using a quality assessment algorithm which combines four widely used consistency tests (Herington, Van Ness, Point/Differential and Infinite Dilution tests) and also a check on the consistencies of the data with the pure component vapor pressures. The overall quality factors, QVLE...

  13. Smartphone-Supported versus Full Behavioural Activation for Depression: A Randomised Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Kien Hoa Ly

    Full Text Available There is need for more cost and time effective treatments for depression. This is the first randomised controlled trial in which a blended treatment--including four face-to-face sessions and a smartphone application--was compared against a full behavioural treatment. Hence, the aim of the current paper was to examine whether a blended smartphone treatment was non-inferior to a full behavioural activation treatment for depression.This was a randomised controlled non-inferiority trial (NCT01819025 comparing a blended treatment (n=46 against a full ten-session treatment (n=47 for people suffering from major depression. Primary outcome measure was the BDI-II, that was administered at pre- and post-treatment, as well as six months after the treatment.Results showed significant improvements in both groups across time on the primary outcome measure (within-group Cohen's d=1.35; CI [-0.82, 3.52] to d=1.47; CI [-0.41, 3.35]; between group d=-0.13 CI [-2.37, 2.09] and d=-0.10 CI [-2.53, 2.33]. At the same time, the blended treatment reduced the therapist time with an average of 47%.We could not establish whether the blended treatment was non-inferior to a full BA treatment. Nevertheless, this study points to that the blended treatment approach could possibly treat nearly twice as many patients suffering from depression by using a smartphone application as add-on. More studies are needed before we can suggest that the blended treatment method is a promising cost-effective alternative to regular face-to-face treatment for depression.Cognitive Behavioral Therapy Treatment of Depression With Smartphone Support NCT01819025.

  14. Estudos de Comunidade e ciências sociais no Brasil

    Directory of Open Access Journals (Sweden)

    Nemuel da Silva Oliveira

    2011-12-01

    Full Text Available O objetivo deste artigo é fazer um balanço da literatura sobre os Estudos de Comunidade (EC no Brasil, destacando o contexto intelectual em que foram produzidos e os debates que suscitaram, especialmente entre as décadas de 1940 e 1960. Método de pesquisa em comunidades, oriundo da Antropologia, em investigações sobre o processo de mudança social, os EC estiveram em voga nos Estados Unidos entre os anos 1920 e 1950, tendo papel fundamental na institucionalização das Ciências Sociais no Brasil. Destacamos três aspectos na produção desses estudos no país, iniciando com uma abordagem conceitual: definições, origem e sua relação com temáticas marcantes nos anos 1950. Em seguida, privilegiamos os aspectos relacionados ao papel dos EC na história das Ciências Sociais no Brasil, com destaque para o processo de institucionalização das Ciências Sociais. Por fim, revisitamos os debates que tais estudos geraram entre os cientistas sociais quanto ao padrão de trabalho sociológico a ser desenvolvido naquele momento.The purpose of this article is to examine the literature about Community Studies(CS in Brazil, highlighting their intellectual context of production and the debates evoked by them, especially between the 1940's and 1960's. As a research method arising from Anthropology on communities in social change process, CS was used in United States between 1920's and 1950's, and played a fundamental role in the institutionalization of Social Sciences in Brazil. Three aspects are highlighted on CS production: first, in a conceptual approach, we discuss their definitions, origins and relation to main topics in the 1950's. The second aspect is related to the role of CS in the history of Social Sciences, especially their institutionalization process. By the end, we revisit the debates between social scientists about the sociological work standard to be developed at that time.

  15. A Ciência de Freud: introdução ao problema da cientificidade da psicanálise

    Directory of Open Access Journals (Sweden)

    Nathalia Sisson

    2010-04-01

    Full Text Available Apresenta-se primeiramente a concepção de Freud do que seria a Ciência e em que constituiria a atividade cientifica, utilizando-se textos freudianos nos quais ele trabalha esse tema. Considera-se as noções de Naturwissenchaft e Geistwissenchaft para contextualizar a discussão sobre a cientificidade da Psicanálise à época de Freud. Confronta-se então a Ciência, como entendida por Freud, com as concepções de Popper e Bachelard, oriundos da Epistemologia. Posteriormente, apresentamos diferentes posições de psicanalistas, como Lacan e Kernberg, quanto ao mesmo tema, para mostrar como a compreensão do que seja a Ciência determina os posicionamentos quanto à relação entre esta e a Psicanálise.

  16. A new method for assessing the accuracy of full arch impressions in patients.

    Science.gov (United States)

    Kuhr, F; Schmidt, A; Rehmann, P; Wöstmann, B

    2016-12-01

    To evaluate a new method of measuring the real deviation (trueness) of full arch impressions intraorally and to investigate the trueness of digital full arch impressions in comparison to a conventional impression procedure in clinical use. Four metal spheres were fixed with composite using a metal application aid to the lower teeth of 50 test subjects as reference structures. One conventional impression (Impregum Penta Soft) with subsequent type-IV gypsum model casting (CI) and three different digital impressions were performed in the lower jaw of each test person with the following intraoral scanners: Sirona CEREC Omnicam (OC), 3M True Definition (TD), Heraeus Cara TRIOS (cT). The digital and conventional (gypsum) models were analyzed relative to the spheres. Linear distance and angle measurements between the spheres, as well as digital superimpositions of the spheres with the reference data set were executed. With regard to the distance measurements, CI showed the smallest deviations followed by intraoral scanners TD, cT and OC. A digital superimposition procedure yielded the same order for the outcomes: CI (15±4μm), TD (23±9μm), cT (37±14μm), OC (214±38μm). Angle measurements revealed the smallest deviation for TD (0.06°±0,07°) followed by CI (0.07°±0.07°), cT (0.13°±0.15°) and OC (0.28°±0.21°). The new measuring method is suitable for measuring the dimensional accuracy of full arch impressions intraorally. CI is still significantly more accurate than full arch scans with intraoral scanners in clinical use. Conventional full arch impressions with polyether impression materials are still more accurate than full arch digital impressions. Digital impression systems using powder application and active wavefront sampling technology achieve the most accurate results in comparison to other intraoral scanning systems (DRKS-ID: DRKS00009360, German Clinical Trials Register). Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Characteristics and determinants of music appreciation in adult CI users.

    Science.gov (United States)

    Philips, Birgit; Vinck, Bart; De Vel, Eddy; Maes, Leen; D'Haenens, Wendy; Keppler, Hannah; Dhooge, Ingeborg

    2012-03-01

    The main objective of this study was to assess the associations between self-reported listening habits and perception of music and speech perception outcomes in quiet and noise for both unilateral cochlear implant (CI) users and bimodal (CI in one ear, hearing aid in contra-lateral ear) users. Information concerning music appreciation was gathered by means of a newly developed questionnaire. Moreover, audiological data (pure-tone audiometry, speech tests in noise and quiet) were gathered and the relationship between speech perception and music appreciation is studied. Bimodal users enjoy listening to music more in comparison with unilateral CI users. Also, music training within rehabilitation is still uncommon, while CI recipients believe that music training might be helpful to maximize their potential with current CI technology. Music training should not be exclusively reserved for the good speech performers. Therefore, a music training program (MTP) that consists of different difficulty levels should be developed. Hopefully, early implementation of MTP in rehabilitation programs can enable adult CI users to enjoy and appreciate music and to maximize their potential with commercially available technology. Furthermore, because bimodal users consider the bimodal stimulation to be the most enjoyable way to listen to music, CI users with residual hearing in the contra-lateral ear should be encouraged to continue wearing their hearing aid in that ear.

  18. A ciência e a tecnologia n’A Capital: da página de fait-divers à página de ciência

    OpenAIRE

    Fonseca, Rui Brito

    2009-01-01

    Durante muito tempo, a ciência e a tecnologia foram olhadas, pela população em geral, como mais um tema de entretenimento e curiosidade, a par de outros. Para a imprensa portuguesa, mormente a imprensa de cariz “popular”, a ciência e a tecnologia também foram durante algum tempo olhadas como um assunto de entretenimento e curiosidade. Partindo da análise, quantitativa e qualitativa, de cerca de 2000 artigos sobre ciência e tecnologia, publicados no jornal diário, pago e de c...

  19. Programa Rede de Residências: Experimentação Arte, Ciência e Tecnologia

    Directory of Open Access Journals (Sweden)

    Ana Noronha

    2015-12-01

    Full Text Available O programa Rede de Residências: Experimentação Arte, Ciência e Tecnologia, que funcionou de 2007 a 2010, resultou de uma parceria entre a Ciência Viva e a Direção-Geral das Artes/Instituto das Artes desenvolvida para criar uma plataforma de trabalho e investigação reunindo artistas e cientistas. Para isto, definiu-se uma rede de instituições científicas de acolhimento, onde 18 artistas desenvolveram projetos de caráter experimental e transdisciplinar com ferramentas e processos específicos dos laboratórios de investigação científica. Esta nota descreve sumariamente as duas edições do programa e dá conta das principais conclusões da sua avaliação.

  20. Correlates of previous couples’ HIV counseling and testing uptake among married individuals in three HIV prevalence strata in Rakai, Uganda

    Directory of Open Access Journals (Sweden)

    Joseph K. B. Matovu

    2015-06-01

    Full Text Available Background: Studies show that uptake of couples’ HIV counseling and testing (couples’ HCT can be affected by individual, relationship, and socioeconomic factors. However, while couples’ HCT uptake can also be affected by background HIV prevalence and awareness of the existence of couples’ HCT services, this is yet to be documented. We explored the correlates of previous couples’ HCT uptake among married individuals in a rural Ugandan district with differing HIV prevalence levels. Design: This was a cross-sectional study conducted among 2,135 married individuals resident in the three HIV prevalence strata (low HIV prevalence: 9.7–11.2%; middle HIV prevalence: 11.4–16.4%; and high HIV prevalence: 20.5–43% in Rakai district, southwestern Uganda, between November 2013 and February 2014. Data were collected on sociodemographic and behavioral characteristics, including previous receipt of couples’ HCT. HIV testing data were obtained from the Rakai Community Cohort Study. We conducted multivariable logistic regression analysis to identify correlates that are independently associated with previous receipt of couples’ HCT. Data analysis was conducted using STATA (statistical software, version 11.2. Results: Of the 2,135 married individuals enrolled, the majority (n=1,783, 83.5% had been married for five or more years while (n=1,460, 66% were in the first-order of marriage. Ever receipt of HCT was almost universal (n=2,020, 95%; of those ever tested, (n=846, 41.9% reported that they had ever received couples’ HCT. There was no significant difference in previous receipt of couples’ HCT between low (n=309, 43.9%, middle (n=295, 41.7%, and high (n=242, 39.7% HIV prevalence settings (p=0.61. Marital order was not significantly associated with previous receipt of couples’ HCT. However, marital duration [five or more years vis-à-vis 1–2 years: adjusted odds ratio (aOR: 1.06; 95% confidence interval (95% CI: 1.04–1.08] and

  1. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer: a population-based study

    Science.gov (United States)

    Fischer, Alexander H.; Wang, Timothy S.; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L.

    2016-01-01

    Background Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit UV exposure. Objective To determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. Methods We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (95% CI), taking into account the complex survey design. Results Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% versus 27.0%; aPOR=1.41; 1.16–1.71), long sleeves (20.5% versus 7.7%; aPOR=1.55; 1.21–1.98), a wide-brimmed hat (26.1% versus 10.5%; aPOR=1.52; 1.24–1.87), and sunscreen (53.7% versus 33.1%; aPOR=2.11; 95% CI=1.73–2.59), but did not have significantly lower odds of recent sunburn (29.7% versus 40.7%; aPOR=0.95; 0.77–1.17). Among subjects with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Limitations Self-reported cross-sectional data and unavailable information quantifying regular sun exposure. Conclusion Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. PMID:27198078

  2. Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP

    DEFF Research Database (Denmark)

    Lundby, Alicia; Akemann, Walther; Knöpfel, Thomas

    2010-01-01

    A voltage sensitive phosphatase was discovered in the ascidian Ciona intestinalis. The phosphatase, Ci-VSP, contains a voltage-sensing domain homologous to those known from voltage-gated ion channels, but unlike ion channels, the voltage-sensing domain of Ci-VSP can reside in the cell membrane...... as a monomer. We fused the voltage-sensing domain of Ci-VSP to a pair of fluorescent reporter proteins to generate a genetically encodable voltage-sensing fluorescent probe, VSFP2.3. VSFP2.3 is a fluorescent voltage probe that reports changes in membrane potential as a FRET (fluorescence resonance energy....... Neutralization of an arginine in S4, previously suggested to be a sensing charge, and measuring associated sensing currents indicate that this charge is likely to reside at the membrane-aqueous interface rather than within the membrane electric field. The data presented give us insights into the voltage-sensing...

  3. Alguns efeitos do discurso da ciência na atualidade

    Directory of Open Access Journals (Sweden)

    Cristóvão Giovani Burgarelli

    2010-08-01

    Full Text Available Este artigo pretende discutir um dos desdobramentos da ciência em especial: a tecnociência, considerada aqui como marca da contemporaneidade que dita o imperativo da técnica e de seu aparato como aquilo que, supostamente, a tudo responde, preenche e satisfaz. O meio acadêmico, inserido no contexto cultural atravessado pela lógica tecnocientífica, não está livre de seus efeitos e da dinâmica consumista que tende a considerar o saber como um bem de consumo. Ao contrário, tanto as escolas quanto as universidades aderem a essa lógica e expulsam de seu arcabouço a possibilidade de subjetivação, ou seja, o modo singular de um sujeito se haver, diferentemente, com as marcas que o constituem.

  4. Accuracy of the QuantiFERON-TB Gold in Tube for diagnosing tuberculosis in a young pediatric population previously vaccinated with Bacille Calmette-Guerin

    Directory of Open Access Journals (Sweden)

    Marcelo Genofre Vallada

    2014-03-01

    Full Text Available Objective: To evaluate the accuracy of an interferongamma release assay (QuantiFERON-TB Gold in Tube for diagnosing Mycobacterium tuberculosis infection in a young pediatric population. Methods: 195 children previously vaccinated with BCG were evaluated, being 184 healthy individuals with no clinical or epidemiological evidence of mycobacterial infection, and 11 with Mycobacterium tuberculosis infection, according to clinical, radiological, and laboratory parameters. A blood sample was obtained from each child and processed according to the manufacturer's instructions. The assay performance was evaluated by a Receiver Operating Characteristic (ROC curve. Results: In the group of 184 non-infected children, 130 (70.6% were under the age of four years (mean age of 35 months. In this group, 177 children (96.2% had negative test results, six (3.2% had indeterminate results, and one (0.5% had a positive result. In the group of 11 infected children, the mean age was 58.5 months, and two of them (18% had negative results. The ROC curve had an area under the curve of 0.88 (95%CI 0.82-0.92; p<0.001, disclosing a predictive positive value of 81.8% for the test (95%CI 46.3-97.4. The assay sensitivity was 81.8% (95%CI 48.2-97.2 and the specificity was 98.8% (95%CI 96-99.8. Conclusions: In the present study, the QuantiFERON-TB Gold in Tube performance for diagnosing M. tuberculosis infection was appropriate in a young pediatric population.

  5. Przykład utraty stateczności ściany frontowej pozostawionej po rozebraniu kamienicy

    Directory of Open Access Journals (Sweden)

    Janusz Laskowski

    2018-04-01

    Full Text Available W artykule przedstawiono opis ściany frontowej budynku pozostawionej po jego rozbiórce. Prowizoryczne zabezpieczenie tej ściany oraz wpływ czynników zewnętrznych, w tym geologicznych, przyczyniły się do utraty przez tę ścianę stateczności, co przy braku jakichkolwiek skutecznych zabezpieczeń może doprowadzić do katastrofy budowlanej.

  6. In-cylinder Combustion and Soot Evolution in the Transition from Conventional CI mode to PPC

    KAUST Repository

    An, Yanzhao

    2018-01-09

    The present study intends to explore the in-cylinder combustion and evolution of soot emission during the transition from conventional compression ignition (CI) combustion to partially premixed combustion (PPC) at low load conditions. In-cylinder combustion images and engine-out emissions were measured in an optical engine fueled with low octane heavy naphtha fuel (RON = 50). Full cycle engine simulations were performed using a three-dimensional computational fluid dynamics code CONVERGETM, coupled with gas phase chemical kinetics, turbulence, and particulate size mimic soot model. The simulations were performed under low load conditions (IMEP ~ 2 to 3 bar) at an engine speed of 1200 rpm. The start of injection (SOI) was advanced from late (-10 CAD aTDC) to early fuel injection timings (-40 CAD aTDC) to realize the combustion transition from CI combustion to PPC. The simulation results of combustion and emission are compared with the experimental results at both CI and PPC combustion modes. The results of the study show a typical low-temperature stratified lean combustion at PPC mode, while high-temperature spray-driven combustion is evident at CI mode. The in-cylinder small intermediates species such as acetylene (C2H2), propargyl (C3H3), cyclopentadienyl (C5H5) and polycyclic aromatic hydrocarbons (PAHs) were significantly suppressed at PPC mode. Nucleation reaction of PAHs collision contributed to main soot mass production. The distribution of soot mass and particle number density was consistent with the distribution of high-temperature zones at CI and PPC combustion modes.

  7. Ciência e arte: relações improváveis? Science and art: unlikely relations?

    Directory of Open Access Journals (Sweden)

    José Claudio Reis

    2006-10-01

    Full Text Available Este artigo discute as relações entre ciência e arte, principalmente entre física e pintura, com o objetivo de apresentar uma abordagem cultural para a ciência. Dessa forma, entendemos que a compreensão dos conteúdos da ciência torna-se mais significativa. Abordamos diferentes momentos da história desde a revolução científica até o século XX. As relações aqui salientadas não buscam uma relação causal entre ciência e arte, mas sim uma visão mais significativa do que é o processo de construção do conhecimento. Assim, a ciência se desnuda para nós como parte da cultura e pode nos ajudar a compreender melhor o processo histórico que nos trouxe até aqui.With the goal of presenting a cultural approach to science, the article discusses relations between science and art, especially between physics and painting. From this standpoint, we can see how understanding the substance of science becomes more important. Different moments in history are examined, from the scientific revolution down through the twentieth century. The relations highlighted herein are not chosen in an effort to undercover a causal relation between science and art but to arrive at a more meaningful understanding of how knowledge is constructed. Science is thus revealed to be part of culture, which can help us better understand the historical process through which we have come to this point.

  8. Bilans w warunkach utraty kontynuacji działalności– zasada ostrożności czy treść ekonomiczna

    Directory of Open Access Journals (Sweden)

    Ewa Walińska

    2009-10-01

    Full Text Available Przedmiotem rozważań w niniejszym artykule są obecnie obowiązujące zasady sporządzania bilansu przedsiębiorstwa, które straciło zdolność do kontynuacji działalności z powodu postępowania upadłościowego. Bilans likwidacyjny rozpoczyna ostatni cykl życia przedsiębiorstwa – zakończenie jego działalności. W tym okresie zmieniają się cele działalności gospodarczej: jedynym celem staje się sprzedaż jego majątku. Brak zasady kontynuacji działalności przedsiębiorstwa upoważnia, zdaniem autorów, do odstępstw od pewnych zasad rachunkowości, głównie ostrożności, na rzecz zasady treści ekonomicznej. Takie odstępstwo realizuje zapisaną w prawie bilansowym koncepcję true and fair. W artykule postuluje się przyjęcie do wyceny majątku w bilansie likwidacyjnym wartości zbywczej niezależnie od tego, czy jest ona wyższa, czy niższa od jego wartości księgowej.

  9. Dzieło sztuki na granicy przeszłości i przyszłości. Historia i patriotyzm w sztuce nieprofesjonalnej

    Directory of Open Access Journals (Sweden)

    Aleksandra Weronika Jarysz

    2016-01-01

    Full Text Available A work of art – a link between the present and the past. History and patriotism in non-professional art In her article, the author discusses art of non-professional artists who shape the national identity in an original way. In the former professional art, the works which illustrated and uplifted history were very popular. This phenomenon is still present among folk, naive, intuitive artists, generally speaking – non-professionals. The work of their hands and imagination is a tool serving the purpose of national values and ideas, and is sometimes the basis for broader considerations on the human condition. They balance between historical facts and ahistorical generalities. The martyrdom of the Polish nation with emphasis on the events of WWII has been inspiring artists, stimulating their imagination and artistic creation. Therefore numerous ‘monuments of patriotic art’ can be found in the wood sculpture, ceramics, painting, and glass painting works from the art collection of the Toruń Maria Znamierowska-Prüfferowa Ethnographic Museum.   Dzieło sztuki na granicy przeszłości i przyszłości. Historia i patriotyzm w sztuce nieprofesjonalnej W swoim artykule autorka prezentuje sztukę twórców nieprofesjonalnych, którzy w sposób oryginalny kształtują tożsamość narodową. W dawnej sztuce profesjonalnej dzieła, które ilustrowały i uwznioślały historię były bardzo popularne. To zjawisko jest nadal aktualne wśród twórców ludowych, naiwnych, intuicyjnych, ogólnie nazywając – nieprofesjonalnych. Dzieło ich rąk i wyobraźni jest narzędziem w służbie wartości i idei narodowych, a niekiedy stanowi podstawę do szerszych rozważań nad kondycją człowieka. Balansują oni między konkretem historycznym a ahistoryczną ogólnością. Martyrologia narodu polskiego z naciskiem na wydarzenia II wojny światowej inspirowała i inspiruje twórców, pobudza ich wyobraźnię i zmusza do twórczej kreacji. Stąd też zar

  10. Pomiar wiarygodności internetowych serwisów handlowych.

    OpenAIRE

    Garnik, Igor; Basińska, Beata

    2011-01-01

    Rozwój handlu internetowego jest odpowiedzią na zapotrzebowanie klientów na tę formę dystrybucji towarów i usług. Z tego powodu, zarządzanie witryną sklepu internetowego, w celu zwiększenia jej wiarygodności, a co za tym idzie – konkurencyjności, jest ważnym zadaniem stojącym przed podmiotami prowadzącymi działalność gospodarczą w sieci. Celem niniejszej pracy było zaproponowanie nowej metody oceny wiarygodności serwisów WWW. Badanie przeprowadzono w grupie 225 osób (83% doświadczonych i 17% ...

  11. Full Length Research paper

    African Journals Online (AJOL)

    Marcos

    2012-08-21

    Aug 21, 2012 ... 1Universidade Estadual Paulista, Faculdade de Ciências Agronômicas, CEP: 18601-060, Botucatu, SP, Brasil. 2Universidade Federal de Alagoas, Centro de Ciências Agrárias-CECA, Maceio, AL, Brasil. 3Universidade Federal Rural do Semi-Árido, Departamento de Ciências Vegetais, Mossoró, RN, Brasil ...

  12. Using the Web for Competitive Intelligence (CI) Gathering

    Science.gov (United States)

    Rocker, JoAnne; Roncaglia, George

    2002-01-01

    Businesses use the Internet as a way to communicate company information as a way of engaging their customers. As the use of the Web for business transactions and advertising grows, so too, does the amount of useful information for practitioners of competitive intelligence (CI). CI is the legal and ethical practice of information gathering about competitors and the marketplace. Information sources like company webpages, online newspapers and news organizations, electronic journal articles and reports, and Internet search engines allow CI practitioners analyze company strengths and weaknesses for their customers. More company and marketplace information than ever is available on the Internet and a lot of it is free. Companies should view the Web not only as a business tool but also as a source of competitive intelligence. In a highly competitive marketplace can any organization afford to ignore information about the other players and customers in that same marketplace?

  13. Wrap it in rap! - Music Making with Adolescent CI Users

    DEFF Research Database (Denmark)

    Petersen, Bjørn; Sørensen, Stine Derdau; Pedersen, Ellen Raben

    2015-01-01

    The purpose of this study was to examine 1) the potential effects of an intensive musical ear training program on the perception of music and speech in prelingually hearing impaired adolescent cochlear implant (CI) users and 2) these adolescents’ music engagement. Eleven adolescent CI users parti...... and repetitive focus on language, articulation, rhythm and rhyme and might even represent a possible form of artistic expression for some of the young CI users....

  14. O livro didático de ciências: problemas e soluções Science texbooks: problems and solutions

    Directory of Open Access Journals (Sweden)

    Jorge Megid Neto

    2003-01-01

    Full Text Available Analisa a temática do livro didático para o ensino de Ciências no Brasil e apresenta alternativas a este recurso, tendo em conta: as atuais características dos manuais didáticos; os usos dos compêndios escolares pelos professores; as novas propostas curriculares para o ensino de Ciências; os resultados da pesquisa educacional sobre ensino de Ciências e sobre os livros didáticos no Brasil.This article analyses the theme of didactic books for Science teaching in Brazil and it presents alternatives to this resource. The main points analyzed are: the characteristics of didactic books; the use by teachers of school texts; the new curricular proposals for science teaching; the results of educational research about science teaching and about textbooks in Brazil.

  15. A evolução da ciência da informação a partir de conceitos-sinônimos empregados na obra ciência da informação ou informática?

    Directory of Open Access Journals (Sweden)

    Marco Donizete Paulino da Silva

    2012-01-01

    Full Text Available Este trabalho foi desenvolvido a partir de uma análise bibliográfica sobre artigos que compõem o livro Informática ou Ciência da Informação?, organizado por Hagar Espanha Gomes, em 1980. Estrutura-se como projeto de revisão histórica em que se narra as impressões estabelecidas durante leitura da obra, evidenciando os termos considerados relevantes e coletando-os para análise posterior do contexto em que estes foram empregados. Deduziu-se, dessa análise, a forma como a Ciência da Informação foi sendo reconhecida como disciplina independente da Biblioteconomia, assim como os níveis de elaboração de cada época a partir dos termos empregados para designá-la.

  16. Przestrzenne nierówności oferty edukacyjnej w zdecentralizowanym systemie oświaty. Przypadek Polski

    Directory of Open Access Journals (Sweden)

    Mikołaj Herbst

    2014-03-01

    Full Text Available Decentralizacja edukacji, podobnie jak decentralizacja wszelkich usług publicznych, wiąże się z ryzykiem zwiększenia nierówności między jednostkami samorządu terytorialnego w zakresie ponoszonych nakładów i jakości usług. W większości państw próbuje się temu zaradzić poprzez ustanowienie krajowych standardów usług edukacyjnych oraz redystrybucję środków finansowych, która pozwala zneutralizować wpływ terytorialnych zróżnicowań bazy podatkowej. Niniejsze opracowanie poświęcone będzie analizie skutecznościowych działań w przypadku Polski. W pierwszej części, na podstawie danych panelowych na poziomie gmin, pokazujemy, że mimo różnych instrumentów wyrównawczych stosowanych przez rząd centralny, lokalna baza podatkowa w znaczącym stopniu wpływa na wysokość nakładów przeznaczanych na edukację gimnazjalną. W części drugiej porównujemy liczbę i charakter przedmiotowy godzin lekcyjnych w gimnazjach położonych w najbiedniejszych i najbogatszych gminach. Wedle naszych ustaleń czas nauczania dla uczniów z najbiedniejszych i najbogatszych środowisk nie jest istotnie różny. Nie występują także znaczące różnice wysokości wynagrodzeń nauczycieli. Biedne i bogate gminy różnią się natomiast zakresem indywidualnego wsparcia dla uczniów.

  17. Nauczanie sprawności komunikacyjnych w grupach ekonomicznych

    OpenAIRE

    Wielkiewicz-Jałmużna, Dorota

    2013-01-01

    Celem nauczania języka polskiego w grupach ekonomicznych jest przede wszystkim rozwijanie kompetencji uczących się. Kluczowe znaczenie mają umiejętności receptywne czyli rozumienie ze słuchu i czytanie. Istotne znaczenie ma również nauczanie sprawności produktywnych to jest mówienia i pisania. Kolejnymi sprawnościami językowymi, które uczniowie zdobywają pod nadzorem nauczyciela są: umiejętność interakcji i mediacji.

  18. Wpływ aktywności fizycznej w okresie ciąży na przebieg porodu = The influence of physical activity during pregnancy on childbirth

    Directory of Open Access Journals (Sweden)

    AGNIESZKA KONSTANCJA PAWŁOWSKA-MUC

    2015-09-01

    3 Ośrodek Kształcenia Podyplomowego Pielęgniarek i Położnych Radomski Szpital Specjalistyczny im. dr Tytusa Chałubińskiego w Radomiu, ul. Lekarska 4   Adres do korespondencji Grażyna Stadnicka Samodzielna Pracownia Umiejętności Położniczych, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny 10-081 Lublin, ul. Staszica 4/6; e-mail:grazyna.stadnicka@umlub.pl   Streszczenie Aktywność fizyczna w czasie ciąży poprawia ogólną kondycję fizyczną i zapobiega dolegliwościom tego okresu. Celem pacy była ocena profilu społeczno-demograficznego kobiet rodzących oraz wpływu aktywności fizycznej w okresie ciąży na przebieg porodu. Materiał i metoda. Badania przeprowadzono wśród 150 rodzących. Narzędzie badawcze stanowiła ankieta własnego autorstwa, skala Borga oraz skala oceny bólu VAS. Wyniki. Badane były w wieku 19-41 lat,  średnia wieku wynosiła 28.7±5.3  lat. Najczęściej podejmowaną przez respondentki aktywnością fizyczną był spacer (n=29; 38.15%, fitness (n=21; 27.63%, joge (n=14; 18.42%, pilates (n=25; 32.89%.Korzystanie z aktywności ruchowej przez kobiety w ciąży było zależne od: wykształcenia (p=0.031, miejsca zamieszkania (p=0.13, statusu zawodowego (0.004 oraz wieku (p=0.042 badanych. Aktywności fizyczna w okresie ciąży miała znamienny statystycznie wpływ na sposób ukończenia ciąży (p=0.024 i wystąpienie samoistnej czynności skurczowej (p=0.001 oraz  bliski istotności statystycznej wpływ na częstość uszkodzenia krocza podczas porodu (0.049. Wnioski. Aktywność fizyczna podczas ciąży nie ma wpływu na częstotliwość okołoporodowych urazów kanału rodnego, w tym nacinania krocza. Natomiast warunkuje wystąpienie samoistnych skurczów porodowych, lepszą tolerancję bólu i wysiłku podczas porodu oraz zmniejsza liczbę cięć cesarskich.   Słowa kluczowe: ciąża, aktywność fizyczna, poród.   Abstract Physical activity during pregnancy, which improves overall physical condition and prevents

  19. CiPA: Ongoing testing, future qualification procedures, and pending issues.

    Science.gov (United States)

    Cavero, Icilio; Holzgrefe, Henry

    2015-01-01

    The comprehensive in vitro proarrhythmia assay (CiPA) is a nonclinical, mechanism-based paradigm for assessing drug proarrhythmic liability. The first CiPA assay determines effects on cloned human cardiac ion channels. The second investigates whether the latter study-generated metrics engender proarrhythmic markers on a computationally reconstructed human ventricular action potential. The third evaluates conclusions from, and searches possibly missed effects by in silico analysis, in human stem cell-derived cardiomyocytes (hSC-CMs). CiPA ad hoc Expert-Working Groups have proposed patch clamp protocols for seven cardiac ion channels, a modified O'Hara-Rudy model for in silico analysis, detailed procedures for field (MEA) and action potential (VSD) measurements in hSC-CMs, and 29 reference drugs for CiPA assay testing and validation. CiPA adoption as drug development tool for identifying electrophysiological mechanisms conferring proarrhythmic liability to candidate drugs is a complex, multi-functional task requiring significant time, reflection, and efforts to be fully achieved. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Towards full citizenship: correlates of engagement with the gender identity law among transwomen in Argentina.

    Directory of Open Access Journals (Sweden)

    María Eugenia Socías

    Full Text Available In May 2012, Argentina passed its "Gender Identity" Law, which aimed to address the legal invisibility, discrimination and marginalization that transgender individuals have historically faced. The aim of this study was to explore factors associated with engagement with the Gender Identity Law among transwomen living in Argentina.Data were derived from a 2013 nationwide, cross-sectional study involving transwomen in Argentina. Using multivariate logistic regression, we assessed the prevalence and factors associated with acquiring a gender-congruent identity card within the first 18 months of enactment of the Gender Identity Law.Among 452 transwomen, 260 (57.5% reported that they had obtained a new gender-congruent identity card. In multivariate analysis, factors positively associated with acquiring a new ID were: previously experiencing discrimination by healthcare workers (adjusted odd ratio [aOR] = 2.01, 95% CI: 1.27-3.20; having engaged in transition procedures (aOR = 3.06, 95% CI: 1.58-5.93; and having a job other than sex work (aOR = 1.81, 95% CI: 1.06-3.10. Foreign born transwomen were less likely to have obtained a new ID (aOR = 0.14, 95% CI: 0.06-0.33.More than half of transwomen in our sample acquired a new gender-congruent ID within the first 18 months of enactment of the Gender Identity Law. However, access to and uptake of this right has been heterogeneous. In particular, our findings suggest that the most empowered transwomen may have been among the first to take advantage of this right. Although educational level, housing conditions, HIV status and sex work were not associated with the outcome, foreign-born status was a strong negative correlate of new ID acquisition. Therefore, additional efforts should be made in order to ensure that benefits of this founding policy reach all transwomen in Argentina.

  1. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication.

    Science.gov (United States)

    Korevaar, Daniël A; Cohen, Jérémie F; Spijker, René; Saldanha, Ian J; Dickersin, Kay; Virgili, Gianni; Hooft, Lotty; Bossuyt, Patrick M M

    2016-11-01

    To assess whether conference abstracts that report higher estimates of diagnostic accuracy are more likely to reach full-text publication in a peer-reviewed journal. We identified abstracts describing diagnostic accuracy studies, presented between 2007 and 2010 at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. We extracted reported estimates of sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and diagnostic odds ratio (DOR). Between May and July 2015, we searched MEDLINE and EMBASE to identify corresponding full-text publications; if needed, we contacted abstract authors. Cox regression was performed to estimate associations with full-text publication, where sensitivity, specificity, and AUC were logit transformed, and DOR was log transformed. A full-text publication was found for 226/399 (57%) included abstracts. There was no association between reported estimates of sensitivity and full-text publication (hazard ratio [HR] 1.09 [95% confidence interval {CI} 0.98, 1.22]). The same applied to specificity (HR 1.00 [95% CI 0.88, 1.14]), AUC (HR 0.91 [95% CI 0.75, 1.09]), and DOR (HR 1.01 [95% CI 0.94, 1.09]). Almost half of the ARVO conference abstracts describing diagnostic accuracy studies did not reach full-text publication. Studies in abstracts that mentioned higher accuracy estimates were not more likely to be reported in a full-text publication. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Mensurações em ciência Measurements in science

    Directory of Open Access Journals (Sweden)

    Harley Edson Amaral Bicas

    2003-08-01

    Full Text Available A natureza da mensuração, terminologias e importância de seus usos em ciência são comentados quanto a sistemas numéricos, representações logarítmicas, unidades (com aplicações a medidas do índice de refração, acuidade visual e ângulos, ordens de grandeza, escalas, sensibilidades, leituras e interpolações, algarismos significativos, precisão e exatidão, fidedignidade e significância (clínica e estatística.The nature of mensurations, terminologies and the importance of their uses are commented regarding numerical systems, logarithmic representations, units (with applications to measurements of the index of refraction, visual acuity and angles, orders of magnitude, scales, sensitivity, instrumental readings and interpolations, significant digits, precision and accuracy, reliability and significance (clinical and statistical.

  3. A ciência nas utopias de Campanella, Bacon, Comenius, e Glanvill

    Directory of Open Access Journals (Sweden)

    Bernardo Jefferson de Oliveira

    2002-12-01

    Full Text Available Este artigo analisa comparativamente o papel que a ciência e a técnica ocupam nas sociedades descritas em A cidade do Sol de Tommasio Campanella, a Nova Atlântida de Francis Bacon, Panorthosia de Jan Amós Comenius e o Complemento à Nova Atlântida de Joseph Glanvill.This article evaluates the role that science and technology plays in the societies described by early modern utopias, making a comparative analysis of Tommasio Campanella's City of Sun, Francis Bacon's New Atlantis, Jan Amós Comenius' Panorthosia, and Joseph Glanvill's The summe of my lord Bacon's New Atlantis.

  4. Fałszywy znak równości

    Directory of Open Access Journals (Sweden)

    Efraim Zuroff

    2012-12-01

    Full Text Available The equivalency canard Efraim Zuroff's text, originally published in Haaretz magazine, is a review of Timothy Snyder's Bloodlands. Snyder distinguishes six main mass murders commited by Nazi Germany and Soviet Union during the period of the Third Reich's existence. In Zuroff's opinion there are some significant differences between these tragedies. Dubious comparisons proposed by Snyder made the Holocaust most affected. Describing the Shoah as one of the six equally horryfying mass murders, the author ignores its ideological roots. Roots that sentenced to death all Jews  - regardless of their political views, religious practicies or the level of identification with Jewish community. Moreover Snyder takes no notice of the georaphical scope of the Holocaust. He also does not notice the fact, that the Nazis effectively managed to make so many Europeans their accomplices, who actively supported the Shoah.   Fałszywy znak równości Tekst Efraima Zuroffa, który pierwotnie ukazał się w piśmie Haaretz, to recenzja książki Skrwawione ziemie Timothy Snydera. Snyder wyróżnia sześć głównych masowych mordów popełnionych przez Niemcy i Związek Radziecki w okresie, który odpowiada istnieniu Trzeciej Rzeszy. Istnieją jednak, zdaniem Zuroffa, znaczące różnice między tymi tragediami. Na wątpliwych porównaniach, które proponuje Snyder, najbardziej „ucierpiał” Holokaust. Opisując Shoah jako jeden z sześciu równie straszliwych, masowych mordów, autor pomija jego ideologiczne korzenie, które sprawiały, że na śmierć skazany był każdy bez wyjątku Żyd, niezależnie od jego poglądów politycznych, praktyk religijnych czy stopnia identyfikacji z żydowską wspólnotą. Ponadto Snyder ignoruje ogromny zasięg geograficzny Holokaustu. Nie zauważa także skuteczności, z jaką naziści potrafili uczynić swoimi wspólnikami tak wielu Europejczyków, którzy w konsekwencji aktywnie wspomagali Shoah.

  5. Capturing the Petermann Ice Island Flux With the CI2D3 Database

    Science.gov (United States)

    Crawford, A. J.; Crocker, G.; Mueller, D.; Saper, R.; Desjardins, L.; Carrieres, T.

    2017-12-01

    The Petermann Glacier ice tongue lost >460 km2 of areal extent ( 38 Gt of mass) due to three large calving events in 2008, 2010 and 2012, as well as three previously unrecorded events in 2011 and 2012. Hundreds of ice islands subsequently drifted south between Hall Basin and Newfoundland's Grand Banks, but no systematic data collection or analysis has been conducted for the full flux of fragments prior to the present study. To accomplish this, the Canadian Ice Service's extensive RADARSAT-1 and -2 synthetic aperture radar image archive was mined to create the Canadian Ice Island Drift, Deterioration and Detection (CI2D3) Database. Over 15000 fragments have been digitized in GIS software from 3200 SAR scenes. A unique characteristic of the database is the inclusion of the lineage (i.e., connecting repeat observations or mother-daughter fragments) for all tracked fragments with areas >0.25 km2. This genealogical information was used to isolate ice islands that were about to fracture in order to assess the environmental conditions and morphological characteristics that influence this deterioration mechanism. Fracture counts showed a significant relationship with sea ice concentration (r = -0.56). However, variations in relative thickness played a large role in fracturing likelihood regardless of sea ice conditions. The exceedance probability of the daughter fragment length was calculated, as is often conducted for offshore industry hazard assessment. Grounded ice islands, which are hazards to seafloor installations and disturb benthic ecology, were recognized from their negligible drift speeds and two grounding hot-spots were identified along the Coburg and eastern Baffin island coasts. Petermann ice islands have been noted to drift along specific isobaths due to the influence of bathymetry on ocean currents. 50% of observations occurred between the 100 and 300 m isobaths, and smaller ice islands were observed more frequently in deeper regions. The CI2D3 Database can

  6. Ocena sprawności działania państwa w odniesieniu do skali wydatków publicznych

    Directory of Open Access Journals (Sweden)

    Marta Postuła

    2013-06-01

    Full Text Available Cel: Celem artykułu jest potwierdzenie tezy, że skala wydatkowania środków publicznych nie wpływa na sprawność działania państwa, która w większej skali jest uzależniona od efektywności ich wydatkowania.Metodologia: Autorka opiera się na przeglądzie literatury, przeprowadzonym na podstawie baz artykułów naukowych, oraz na analizie konkretnych rozwiązań obowiązujących w Unii Europejskiej i krajach członkowskich OECD, odnoszących się do konsolidacji funduszy w kontekście sprawności działania państwa.Oryginalność: Na bazie analizy przeprowadzonej w artykule autorka dowodzi, że optymalna polityka fiskalna powinna wykorzystywać dobrze dobrane narzędzia pozwalające na osiągnięcie maksymalnie dobrego sposobu gospodarowania środkami publicznymi w danym otoczeniu zewnętrznym i wewnętrznym, w jakim znajduje się dana gospodarka. Czynnikiem decydującym o sprawności państwa (pomijając czynniki pozafinansowe nie są absolutne i względne rozmiary wydatków publicznych. Poziom sprawności jest uzależniony od struktury tych wydatków oraz procedur związanych zarówno z procesem planowania, realizacji, ewidencji i sprawozdawczości dotyczącej wydatków publicznych, jak i z poziomem systemu oceny efektywności i skuteczności.

  7. Wpływ wykształcenia oraz aktywności fizycznej rodziców na poziom rozwoju zdolności szybkościowych dziewcząt wiejskich w młodszym wieku szkolnym

    Directory of Open Access Journals (Sweden)

    Jarosław Fugiel

    2009-06-01

    Full Text Available Wstęp: Proces rozwoju motorycznego kształtowany jest przez czynniki biogeograficzne, społeczno-ekonomiczne oraz tryb życia, wynika również ze stanu zaawansowania rozwoju somatycznego. Znaczącą rolę przypisuje się zwłaszcza aktywności fizycznej, której poziom różnicowany jest głównie przez takie czynniki jak płeć, wiek,miejsce zamieszkania czy wykształcenie. Poziom aktywności fizycznej znacznie różni się w środowisku miejskim i wiejskim. Sytuacja ta w dużym stopniu wynika z odmiennych warunków socjalno-bytowych, różnic w ilości i dostępności do bazy sportowej oraz niższej świadomości dotyczącej promocji zdrowia. Również wykształcenie rodziców, które wpływa na poziom świadomości dotyczącej kształtowania rozwoju fizycznego potomstwa, jest niższe na wsi w porównaniu do populacji miejskiej. Czynniki te mogą decydować o poziomie i charakterze aktywności fizycznej oraz mogą wpływać na sprawność motoryczną dzieci i młodzieży wiejskiej. Celem pracy była ocena wpływu wykształcenia oraz aktywności fizycznej rodziców na poziom sprawności motorycznej dziewcząt wiejskich z Legnicko-Głogowskiego Zagłębia Miedziowego. Materiał i metody: Materiał do pracy zgromadzono w 1998 r. na terenie Zagłębia Miedziowego. Zbadano 69 dziewcząt w wieku 9 lat z wiejskich szkół okolic Legnicy i Głogowa. Zmierzono wysokość i masę ciała oraz przeprowadzono testy sprawności fizycznej: skok w dal z miejsca, rzut 1 kg piłką lekarską, bieg wahadłowy 10x5m i stukanie w krążki. Informacje na temat wykształcenia rodziców oraz ich aktywności fizycznej w zakresie uprawiania sportu uzyskano za pomocą ankiety. W analizie wykorzystano podstawowe obliczenia statystyczne oraz obliczono test t-Studenta dla grup niezależnych. Wyniki i wnioski: 1. Wykształcenie średnie lub wyższe ojca i matki wpływa na uzyskanie wyższego poziomu rozwoju somatycznego córek. Dziewczęta z tych grup uzyskują r

  8. Determinants of Full Vaccination Status in a Rural Community with ...

    African Journals Online (AJOL)

    user

    12-to-59 month-old children and other variables related to the child were collected from their mothers. . Fisher's ... intervals (CI) were used to explore factors associated with full vaccination. .... attitude towards immunization as they stated that it.

  9. Music Perception and Appraisal: Cochlear Implant Users and Simulated CI Listening

    Science.gov (United States)

    Wright, Rose; Uchanski, Rosalie M.

    2012-01-01

    Background The inability to hear music well may contribute to decreased quality of life for cochlear implant (CI) users. Researchers have reported recently on the generally poor ability of CI users’ to perceive music, and a few researchers have reported on the enjoyment of music by CI users. However, the relation between music perception skills and music enjoyment is much less explored. Only one study has attempted to predict CI users’ enjoyment and perception of music from the users’ demographic variables and other perceptual skills (Gfeller et al., 2008). Gfeller’s results yielded different predictive relationships for music perception and music enjoyment, and the relationships were weak, at best. Purpose The first goal of this study is to clarify the nature and relationship between music perception skills and musical enjoyment for CI users, by employing a battery of music tests. The second goal is to determine whether normal hearing (NH) subjects, listening with a CI-simulation, can be used as a model to represent actual CI users for either music enjoyment ratings or music perception tasks. Research Design A prospective, cross-sectional observational study. Original music stimuli (unprocessed) were presented to CI users, and music stimuli processed with CI-simulation software were presented to twenty NH listeners (CIsim). As a control, original music stimuli were also presented to five other NH listeners. All listeners appraised twenty-four musical excerpts, performed music perception tests, and filled out a musical background questionnaire. Music perception tests were the Appreciation of Music in Cochlear Implantees (AMICI), Montreal Battery for Evaluation of Amusia (MBEA), Melodic Contour Identification (MCI), and University of Washington Clinical Assessment of Music Perception (UW-CAMP). Study Sample Twenty-five NH adults (22 – 56 years old), recruited from the local and research communities, participated in the study. Ten adult CI users (46 – 80

  10. Semiempirical UNO-CAS and UNO-CI: method and applications in nanoelectronics.

    Science.gov (United States)

    Dral, Pavlo O; Clark, Timothy

    2011-10-20

    Unrestricted Natural Orbital-Complete Active Space Configuration Interaction, abbreviated as UNO-CAS, has been implemented for NDDO-based semiempirical molecular-orbital (MO) theory. A computationally more economic technique, UNO-CIS, in which we use a configuration interaction (CI) calculation with only single excitations (CIS) to calculate excited states, has also been implemented and tested. The class of techniques in which unrestricted natural orbitals (UNOs) are used as the reference for CI calculations is denoted UNO-CI. Semiempirical UNO-CI gives good results for the optical band gaps of organic semiconductors such as polyynes and polyacenes, which are promising materials for nanoelectronics. The results of these semiempirical UNO-CI techniques are generally in better agreement with experiment than those obtained with the corresponding conventional semiempirical CI methods and comparable to or better than those obtained with far more computationally expensive methods such as time-dependent density-functional theory. We also show that symmetry breaking in semiempirical UHF calculations is very useful for predicting the diradical character of organic compounds in the singlet spin state.

  11. Youth suicide: an insight into previous hospitalisation for injury and sociodemographic conditions from a nationwide cohort study.

    Science.gov (United States)

    Zambon, Francesco; Laflamme, Lucie; Spolaore, Paolo; Visentin, Cristiana; Hasselberg, Marie

    2011-06-01

    This study investigates the degree to which a previous hospitalisation for injury of any intent is a risk of subsequent youth suicide and whether this association is influenced by family socioeconomic status or economic stress. A nationwide register-based cohort study was conducted covering all Swedish subjects born between January 1977 and December 1991 (N=1,616,342, male/female ratio=1.05). The cohort subjects were followed-up from January 1998 to December 2003, when aged 7-26 years. Poisson regression and the likelihood ratio test (95% CI) were used to assess the age-adjusted effect of hospitalisation for injuries of various intent on youth suicide and its effect once adjusted for family sociodemographic and social circumstances. Each set of exposures was associated independently and significantly with suicide mortality. Being hospitalised for self-inflicted injuries or injuries of undetermined intent was associated with a risk of suicide 36 to 47 times, respectively, that of subjects never hospitalised in the period under study (95% CI 28.36 to 45.58 and 26.67 to 83.87 for self-inflicted injuries and for events of undetermined intent, respectively; overall psuicide (RR 3.08; 95% CI 2.26 to 4.19). These effects were solid and not substantially altered after adjustment for family demographic and socioeconomic circumstances. A strong association exists between previous hospitalisation for injury of any intent and youth suicide. The association is robust and unaltered by family socioeconomic circumstances.

  12. Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women

    OpenAIRE

    Urtnowska, Katarzyna; Bułatowicz, Irena; Ludwikowski, Grzegorz; Zukow, Walery

    2016-01-01

    Urtnowska Katarzyna, Bułatowicz Irena, Ludwikowski Grzegorz, Zukow Walery. Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women. Journal of Education, Health and Sport. 2016;6(5):291-297. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.51894 http://ojs.ukw.edu.pl/index.php/johs/article/view/3526 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23...

  13. Time course of auditory streaming: Do CI users differ from normal-hearing listeners?

    Directory of Open Access Journals (Sweden)

    Martin eBöckmann-Barthel

    2014-07-01

    Full Text Available In a complex acoustical environment with multiple sound sources the auditory system uses streaming as a tool to organize the incoming sounds in one or more streams depending on the stimulus parameters. Streaming is commonly studied by alternating sequences of signals. These are often tones with different frequencies. The present study investigates stream segregation in cochlear implant (CI users, where hearing is restored by electrical stimulation of the auditory nerve. CI users listened to 30-s long sequences of alternating A and B harmonic complexes at four different fundamental frequency separations, ranging from 2 to 14 semitones. They had to indicate as promptly as possible after sequence onset, if they perceived one stream or two streams and, in addition, any changes of the percept throughout the rest of the sequence. The conventional view is that the initial percept is always that of a single stream which may after some time change to a percept of two streams. This general build-up hypothesis has recently been challenged on the basis of a new analysis of data of normal-hearing listeners which showed a build-up response only for an intermediate frequency separation. Using the same experimental paradigm and analysis, the present study found that the results of CI users agree with those of the normal-hearing listeners: (i the probability of the first decision to be a one-stream percept decreased and that of a two-stream percept increased as Δf increased, and (ii a build-up was only found for 6 semitones. Only the time elapsed before the listeners made their first decision of the percept was prolonged as compared to normal-hearing listeners. The similarity in the data of the CI user and the normal-hearing listeners indicates that the quality of stream formation is similar in these groups of listeners.

  14. OCENA WŁAŚCIWOŚCI PRZECIWPOŚLIZGOWYCH NAWIERZCHNI DROGOWYCH PRZY WYKORZYSTANIU URZĄDZEŃ TWO, CTM I DFT

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    Marta WASILEWSKA

    2016-07-01

    Full Text Available Kompleksowa ocena właściwości przeciwpoślizgowych powinna być wykonywana w oparciu o ciągły pomiar współczynnika tarcia oraz parametrów dotyczących tekstury nawierzchni drogowych. W artykule przedstawiono ocenę właściwości przeciwpoślizgowych nawierzchni drogowych przeprowadzoną na podstawie pomiarów wykonanych zestawem pomiarowym TWO (Traction Watcher One oraz urządzeniami CTM (Circular Track Meter i DFT (Dynamic Friction Tester. Do badań wytypowano 11 odcinków testowych, których warstwy ścieralne były zróżnicowane pod względem technologii wykonania, okresu użytkowania i obciążenia ruchem samochodowym. Przy pomocy urządzenia CTM dokonano oceny makrotekstury (parametr MPD, a przy wykorzystaniu urządzenia DFT oceniano w sposób pośredni mikroteksturę powierzchni (współczynnik tarcia DFT20. Urządzenie TWO umożliwiło ciągły pomiar współczynnika tarcia z ustalonym poślizgiem 17,8% koła pomiarowego przy trzech prędkościach 30, 60, 90 km/h. W artykule ustalono zależności funkcyjne pomiędzy współczynnikiem tarcia µ z pomiarów TWO, a współczynnikiem DFT20 i parametrem MPD. Wykazano, że na wartość µ przy prędkości 30 km/h istotny wpływ ma jedynie mikrotekstura nawierzchni, a przy prędkości 60 i 90 km/h zarówno mikrotekstura i makrotekstura.

  15. Is Uric Acid a Missing Link between Previous Gestational Diabetes Mellitus and the Development of Type 2 Diabetes at a Later Time of Life?

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    Piotr Molęda

    Full Text Available A high level of uric acid (UA is a strong, independent risk factor for type 2 diabetes mellitus. The relationship between UA levels and the development of type 2 diabetes in women with previous gestational diabetes mellitus (pGDM remains unclear. The aim of study was to evaluate the UA levels in pGDM women in relation to their current nutritional status and carbohydrate metabolism.199 women with pGDM diagnoses based on oral glucose tolerance tests (OGTTs 5-12 years previously and a control group of 50 women without pGDM. The assessment included anthropometric parameters, body composition (Tanita SC-330S, current OGTT, insulin resistance index (HOMA-IR, β-cell function (HOMA-%B, HbA1c, lipids, and uric acid.No differences between groups were found in terms of age, time from the index pregnancy, anthropometric parameters, lipids or creatinine levels. The incidences of overweight and obesity were similar. Carbohydrate abnormalities were more frequent in the pGDM group than the control group (43.2% vs 12.0% p<0.001. The women with pGDM had significantly higher fasting glucose, HbA1c, glucose and insulin levels in the OGTTs, but similar HOMA-IR values. Their UA levels were significantly higher (258±58 vs 230±50 μmol/L, p<0.005 and correlated with BMI and the severity of carbohydrate disorders. The normal weight and normoglycemic pGDM women also demonstrated higher UA levels than a similar control subgroup (232±48 vs 208±48 μmol/L, p<0.05. Multivariate analysis revealed significant correlations of UA level with BMI (β = 0.38, 95% CI 0.25-0.51, p<0.0001, creatinine level (β = 0.23, 95% CI 0.11-0.35, p<0.0005, triglycerides (β = 0.20, 95% CI 0.07-0.33, p<0.005 and family history of diabetes (β = 0.13, 95% CI 0.01-0.25, p<0.05. In logistic regression analysis, the association between higher UA level (defined as value ≥297 μmol/L and presence of any carbohydrate metabolism disorder (IFG, IGT or diabetes was statistically significant (odds

  16. Etyka w zawodzie specjalisty rachunkowości zarządczej w podręcznikach i kształceniu w Polsce

    Directory of Open Access Journals (Sweden)

    Irena Sobańska

    2016-07-01

    Full Text Available Celem artykułu jest poznanie, jak środowisko naukowe rachunkowości wspiera zawód specjalisty ra- chunkowości zarządczej w uświadamianiu wysokich wymagań etycznych oczekiwanych od tego zawo- du. W artykule zostały przedstawione zagadnienia dotyczące etyki w zawodzie specjalisty rachunkowości zarządczej w świetle badań i standardów międzynarodowych oraz wyniki i wnioski z badań treści pol- skich podręczników akademickich i programów kształcenia. Przeprowadzone badania pozwoliły pozy- tywnie zweryfikować postawioną hipotezę, mówiącą, że w procesie kształcenia akademickiego zagad- nienia etyki zawodu specjalisty rachunkowości zarządczej nie są w ogóle lub w minimalnym zakresie objaśniane. Stanowi to wskazówkę do udoskonalenia programów kształcenia w badanym zakresie na uczelniach wyższych w Polsce.

  17. Czytanie Muranowa. Pamięć miejsca / pamięć architekta Komentarz do powojennej twórczości Bohdana Lacherta

    Directory of Open Access Journals (Sweden)

    Uchowicz, Katarzyna

    2014-12-01

    Full Text Available Tekst koncentruje się wokół koncepcji Muranowa Południowego – osiedla / pomnika zrealizowanego na terenie warszawskiego getta przez architekta Bohdana Lacherta. Podejmuje próbę ukazania realizacji w kategoriach mitu artystycznego wykreowanego przez twórcę. Analiza tekstów autora, rekonstrukcja okoliczności towarzyszących budowie oraz szczegóły artystycznej biografii odsłaniają nowe warstwy architektonicznego palimpsestu. Czytelne nawiązania do śmiałych wizji Śródmieścia Macieja Nowickiego oraz zaadaptowanie dla idei osiedla /miejsca pamięci powszechnych w latach czterdziestych eksperymentalnych prób przetwarzania gruzu prowokują pytania o oryginalność koncepcji Muranowa, którego niewątpliwą wartością pozostaje kompozycja przestrzenna wyrastająca z pionierskich poszukiwań Katarzyny Kobro, architektury organicznej Franka Lloyda Wrighta oraz nowego funkcjonalizmu Nowickiego. Historia osiedla to jednocześnie mikrokosmos pierwszych lat odbudowy Warszawy i socrealistycznego chaosu po roku 1949 oraz zapis poszukiwań artystycznej podmiotowości architekta modernisty w nowej rzeczywistości.

  18. Haplotype association between haptoglobin (Hp2 and Hp promoter SNP (A-61C may explain previous controversy of haptoglobin and malaria protection.

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    Sharon E Cox

    2007-04-01

    Full Text Available Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria susceptibility.Risk of a clinical malarial episode over the course of a malarial transmission season was assessed using active surveillance in a cohort of Gambian children aged 10-72 months. We report for the first time that the major haplotype for the A-61C mutant allele in the promoter of haptoglobin (Hp-an acute phase protein that clears haemoglobin released from haemolysis of red cells-is associated with protection from malarial infection in older children, (children aged >or=36 months, >500 parasites/ul and temperature >37.5 degrees C; OR = 0.42; [95% CI 0.24-0.73] p = 0.002 (lr test for interaction, or=36 months, p = 0.014. Protection was also observed using two other definitions, including temperature >37.5 degrees C, dipstick positive, plus clinical judgement of malaria blinded to dipstick result (all ages, OR = 0.48, [95% CI 0.30-0.78] p = 0.003; >or=36 months, OR = 0.31, [95% CI 0.15-0.62] p = 0.001. A similar level of protection was observed for the known protective genetic variant, sickle cell trait (HbAS.We propose that previous conflicting results between Hp phenotypes/genotypes and malaria susceptibility may be explained by differing prevalence of the A-61C SNP in the populations studied, which we found to be highly associated with the Hp2 allele. We report the -61C allele to be associated with decreased Hp protein levels (independent of Hp phenotype, confirming in vitro studies. Decreased Hp expression may lead to increased oxidant stress and increased red cell turnover, and facilitate the development of acquired immunity, similar to

  19. Powikłania neurologiczne współistniejące z niewydolnością nerek

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    Maria Łukasik

    2010-03-01

    Full Text Available Powikłania neurologiczne w przebiegu niewydolności nerek, zarówno te spowodowane mocznicą, jak i wynikające z jej leczenia, dotyczą ośrodkowego oraz obwodowego układu nerwowego, jak również tkanki mięśniowej i stanowią przyczynę zwiększonej śmiertelności u chorych z niewydolnością nerek. Pacjenci z niewydolnością nerek są szczególnie narażeni na rozwój encefalopatii mocznicowej, encefalopatii nadciśnieniowej, chorób naczyniowych ośrodkowego układu nerwowego bądź zespołów otępiennych. W tej grupie chorych częściej niż w populacji ogólnej rozwijają się mono- i polineuropatie, a choroby nerek należą do częstszych przyczyn zespołu niespokojnych nóg. Pomimo ciągłego postępu terapeutycznego wciąż nie ma skutecznego leczenia wielu tych powikłań, m.in. encefalopatii mocznicowej, miażdżycy, neuropatii czy miopatii. Co więcej, wprowadzenie dializoterapii rozszerzyło spektrum komplikacji o otępienie dializacyjne, krwawienia śródczaszkowe, zespół nierównowagi dializacyjnej, encefalopatię Wernickego i osmotyczną mielinolizę. Leczenie immunosupresyjne stosowane zarówno w chorobach nerek, jak i u chorych po przeszczepie nerki przyczyniło się do rozwoju oportunistycznych infekcji i nowotworzenia w ośrodkowym układzie nerwowym, ponadto niekiedy powikłane jest rozwojem odwracalnej tylnej leukoencefalopatii. Znajomość tych powikłań oraz ścisła współpraca między nefrologami i neurologami mogą przyczynić się do zmniejszenia śmiertelności i poprawy jakości życia chorych z niewydolnością nerek. Należy przy tym pamiętać, że także patologie, które prowadzą do niewydolności nerek (szczególnie choroby układowe tkanki łącznej czy cukrzyca, powodują uszkodzenia ośrodkowego i obwodowego układu nerwowego, a określenie rzeczywistej przyczyny bywa niemożliwe.

  20. A meta-história de Hayden White: uma crítica construtiva à "ciência" histórica

    Directory of Open Access Journals (Sweden)

    Paul Sutermeister

    2009-06-01

    Full Text Available Apresenta-se brevemente a teoria da história-narrativa de Hayden White, seus conceitos e críticas. Por analisar objetivamente a questão da verdade na historiografia, White contribuiu para uma conscientização, não só na ciência histórica mas também em outras áreas, sobre o dilema entre ciência e retórica. Trata-se de um dilema que mesmo os críticos mais severos de White, como o historiador Carlo Ginzburg, devem enfrentar. 

  1. Polska prasa tabletowa – modele biznesowe dystrybucji treści

    Directory of Open Access Journals (Sweden)

    Krzysztof Flasiński

    2012-02-01

    Full Text Available Autor przeanalizował aplikacje spełniające trzy warunki: przeznaczone na tablety marki iPad, dostępne w sklepie App Store oraz powiązane z polskojęzycznymi tytułami prasowymi. Artykuł przedstawia kompletną panoramę polskiej prasy tabletowej. Ujętych zostało 38 aplikacji dostępnych 30 września 2011 r. Po zbadaniu wszystkich programów utworzono „mapę modeli biznesowych dystrybucji treści”. Czynnikiem decydującym o umieszczeniu na niej aplikacji prasowych była forma dystrybucji treści (płatna/bezpłatna oraz  rodzaj udostępnianej treści (powiązana z wydaniem drukowanym/powiązana z wydaniem online. Z analizy wynika, że 11 redakcji udostępnia płatne wydanie print, 10 – bezpłatne wydanie online, 7 – bezpłatne wydanie print, 3 – bezpłatne wydanie online oraz płatne wydanie print, jedna – oba wydania bezpłatnie, i jedna – oba wydania płatnie. Wywód uzupełniają dodatkowe dane: chronologiczna lista aplikacji prasowych według daty ukazania, wykaz kosztów korzystania z poszczególnych aplikacji, aktywność wydawców prasowych w App Store w rozbiciu na miesiące oraz kwartały.

  2. Vitamin D deficiency in medical patients at a central hospital in Malawi: a comparison with TB patients from a previous study.

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    Yamikani Mastala

    Full Text Available OBJECTIVES: To determine the prevalence of vitamin D deficiency (VDD in adult medical, non-tuberculous (non-TB patients. To investigate associations with VDD. To compare the results with a similar study in TB patients at the same hospital. DESIGN: Cross-sectional sample. SETTING: Central hospital in Malawi. PARTICIPANTS: Adult non-TB patients (n = 157, inpatients and outpatients. OUTCOME MEASURES: The primary outcome was the prevalence of VDD. Potentially causal associations sought included nutritional status, in/outpatient status, HIV status, anti-retroviral therapy (ART and, by comparison with a previous study, a diagnosis of tuberculosis (TB. RESULTS: Hypovitaminosis D (≤75 nmol/L occurred in 47.8% (75/157 of patients, 16.6% (26/157 of whom had VDD (≤50 nmol/L. None had severe VDD (≤25 nmol/L. VDD was found in 22.8% (23/101 of in-patients and 5.4% (3/56 of out-patients. In univariable analysis in-patient status, ART use and low dietary vitamin D were significant predictors of VDD. VDD was less prevalent than in previously studied TB patients in the same hospital (68/161 = 42%. In multivariate analysis of the combined data set from both studies, having TB (OR 3.61, 95%CI 2.02-6.43 and being an in-patient (OR 2.70, 95%CI 1.46-5.01 were significant independent predictors of VDD. CONCLUSIONS: About half of adult medical patients without TB have suboptimal vitamin D status, which is more common in in-patients. VDD is much more common in TB patients than non-TB patients, even when other variables are controlled for, suggesting that vitamin D deficiency is associated with TB.

  3. Emission Characteristics of a CI Engine Running with a Range of Biodiesel Feedstocks

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    Belachew Tesfa

    2014-01-01

    Full Text Available Currently, alternative fuels are being investigated in detail for application in compression ignition (CI engines resulting in exciting potential opportunities to increase energy security and reduce gas emissions. Biodiesel is one of the alternative fuels which is renewable and environmentally friendly and can be used in diesel engines with little or no modifications. The objective of this study is to investigate the effects of biodiesel types and biodiesel fraction on the emission characteristics of a CI engine. The experimental work was carried out on a four-cylinder, four-stroke, direct injection (DI and turbocharged diesel engine by using biodiesel made from waste oil, rapeseed oil, corn oil and comparing them to normal diesel. The fuels used in the analyses are B10, B20, B50, B100 and neat diesel. The engine was operated over a range of engine speeds. Based on the measured parameters, detailed analyses were carried out on major regulated emissions such as NOx, CO, CO2, and THC. It has been seen that the biodiesel types (sources do not result in any significant differences in emissions. The results also clearly indicate that the engine running with biodiesel and blends have higher NOx emission by up to 20%. However, the emissions of the CI engine running on neat biodiesel (B100 were reduced by up to 15%, 40% and 30% for CO, CO2 and THC emissions respectively, as compared to diesel fuel at various operating conditions.

  4. Identification of two CiGADs from Caragana intermedia and their transcriptional responses to abiotic stresses and exogenous abscisic acid.

    Science.gov (United States)

    Ji, Jing; Zheng, Lingyu; Yue, Jianyun; Yao, Xiamei; Chang, Ermei; Xie, Tiantian; Deng, Nan; Chen, Lanzhen; Huang, Yuwen; Jiang, Zeping; Shi, Shengqing

    2017-01-01

    Glutamate decarboxylase (GAD), as a key enzyme in the γ -aminobutyric acid (GABA) shunt, catalyzes the decarboxylation of L-glutamate to form GABA. This pathway has attracted much interest because of its roles in carbon and nitrogen metabolism, stress responses, and signaling in higher plants. The aim of this study was to isolate and characterize genes encoding GADs from Caragana intermedia , an important nitrogen-fixing leguminous shrub. Two full-length cDNAs encoding GADs (designated as CiGAD1 and CiGAD2 ) were isolated and characterized. Multiple alignment and phylogenetic analyses were conducted to evaluate their structures and identities to each other and to homologs in other plants. Tissue expression analyses were conducted to evaluate their transcriptional responses to stress (NaCl, ZnSO 4 , CdCl 2 , high/low temperature, and dehydration) and exogenous abscisic acid. The CiGAD s contained the conserved PLP domain and calmodulin (CaM)-binding domain in the C-terminal region. The phylogenetic analysis showed that they were more closely related to the GADs of soybean, another legume, than to GADs of other model plants. According to Southern blotting analysis, CiGAD1 had one copy and CiGAD2 -related genes were present as two copies in C. intermedia . In the tissue expression analyses, there were much higher transcript levels of CiGAD2 than CiGAD1 in bark, suggesting that CiGAD2 might play a role in secondary growth of woody plants. Several stress treatments (NaCl, ZnSO 4 , CdCl 2 , high/low temperature, and dehydration) significantly increased the transcript levels of both CiGAD s, except for CiGAD2 under Cd stress. The CiGAD1 transcript levels strongly increased in response to Zn stress (74.3-fold increase in roots) and heat stress (218.1-fold increase in leaves). The transcript levels of both CiGAD s significantly increased as GABA accumulated during a 24-h salt treatment. Abscisic acid was involved in regulating the expression of these two CiGAD s under salt

  5. A cobertura de ciência em três jornais paraenses: um estudo longitudinal

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    Vanessa Brasil de Carvalho

    Full Text Available Resumo Neste artigo, apresentamos uma proposta metodológica visando realizar um estudo longitudinal que fornecesse um panorama da cobertura de ciência em 130 anos, por três jornais importantes do Estado do Pará: A Província do Pará (1876-2002, Folha do Norte (1896-1974 e O Liberal (1946-atual. Analisamos um período de dois meses a cada dez anos, de 1876 a 2006, em cada jornal selecionado, de maneira que obtivemos um olhar em longo prazo que perpassou pela história dos periódicos e, portanto, por grande parte da história da imprensa no Pará e na Amazônia. Utilizamos análise de conteúdo e análise de frames da Mídia. Nossos dados mostram que houve ênfase na pesquisa em saúde, destaque para a ciência nacional e preocupação em contextualizar os fatos científicos. Controvérsias e incertezas científicas ganharam pouco espaço nos jornais analisados.

  6. Limited versus full sternotomy for aortic valve replacement.

    Science.gov (United States)

    Kirmani, Bilal H; Jones, Sion G; Malaisrie, S C; Chung, Darryl A; Williams, Richard Jnn

    2017-04-10

    , assess quality, and identify risk of bias. A third review author provided arbitration where required. The quality of evidence was determined using the GRADE methodology and results of patient-relevant outcomes were summarised in a 'Summary of findings' table. The review included seven trials with 511 participants. These included adults from centres in Austria, Spain, Italy, Germany, France, and Egypt. We performed 12 comparisons investigating the effects of minimally invasive limited upper hemi-sternotomy on aortic valve replacement as compared to surgery performed via full median sternotomy.There was no evidence of any effect of upper hemi-sternotomy on mortality versus full median sternotomy (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.36 to 2.82; participants = 511; studies = 7; moderate quality). There was no evidence of an increase in cardiopulmonary bypass time with aortic valve replacement performed via an upper hemi-sternotomy (mean difference (MD) 3.02 minutes, 95% CI -4.10 to 10.14; participants = 311; studies = 5; low quality). There was no evidence of an increase in aortic cross-clamp time (MD 0.95 minutes, 95% CI -3.45 to 5.35; participants = 391; studies = 6; low quality). None of the included studies reported major adverse cardiac and cerebrovascular events as a composite end point.There was no evidence of an effect on length of hospital stay through limited hemi-sternotomy (MD -1.31 days, 95% CI -2.63 to 0.01; participants = 297; studies = 5; I 2 = 89%; very low quality). Postoperative blood loss was lower in the upper hemi-sternotomy group (MD -158.00 mL, 95% CI -303.24 to -12.76; participants = 297; studies = 5; moderate quality). The evidence did not support a reduction in deep sternal wound infections (RR 0.71, 95% CI 0.22 to 2.30; participants = 511; studies = 7; moderate quality) or re-exploration (RR 1.01, 95% CI 0.48 to 2.13; participants = 511; studies = 7; moderate quality). There was no change in pain scores by upper hemi

  7. A relação interdisciplinar entre a ciência da informação e a ciência da comunicação: o estudo da informação e do conhecimento na biblioteconomia e no jornalismo / The interdiciplinary relationship between information science and communication science: the study of information and knowledge in librarianship and journalism

    Directory of Open Access Journals (Sweden)

    Sandryne Bernardino Barreto Januário

    2010-07-01

    Full Text Available Trata da relação interdisciplinar entre a Ciência da Informação e a Ciência da Comunicação, através do estudo dos “objetos” informação e conhecimento em duas de suas áreas, a Biblioteconomia e o Jornalismo, respectivamente. Analisa ainda aspectos semelhantes e diferentes dos objetos nas áreas das Ciências.

  8. Masculinidade e ciúme na perspectiva da teoria da sedução generalizada

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    Paulo Carvalho Ribeiro

    2012-09-01

    Full Text Available Partindo das contribuições freudianas sobre as relações do ciúme com a projeção e a homossexualidade, propõe-se no presente artigo uma retomada do papel do masoquismo primário e da identificação feminina como elementos definidores do ciúme masculino patológico. As condições originárias de constituição do psiquismo, vistas sob o ângulo da Teoria da Sedução Generalizada, proposta por Jean Laplanche, são relacionadas tanto ao masoquismo primário quanto à identificação feminina. A situação assimétrica entre o adulto, portador de uma sexualidade inconsciente, e a criança, destituída de recursos psíquicos para lidar com as mensagens sexuais do adulto, caracteriza, segundo esse autor, a situação antropológica fundamental.

  9. Do estilo em ciência e em história das ciências

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    Michel Paty

    2012-08-01

    Full Text Available Ao considerar o conhecimento científico como uma forma de pensamento simbólico, entende-se com isso não simples sistemas de signos, mas conteúdos de pensamento (expressos por conceitos ligados entre si e que fazem sentido, que são, no espaço das representações mentais, os substitutos do "dado objetivo" que se supõe subjazer à experiência que fazemos do "mundo" pelos sentidos e, nesse nível indissociavelmente, pelo entendimento. Esse pensamento simbólico adquire densidade e consistência pela "tecelagem" realizada graças ao trabalho dos pensamentos individuais que se comunicam, social e culturalmente, inscritos no tempo da história. Da tensão dinâmica entre o sujeito do conhecimento, que busca a inteligibilidade (pela operação de sua razão, e a objetividade dos conteúdos que ele se propõe (inicialmente dados, depois modificados ou produzidos, resulta o movimento do pensamento científico e a transformação dos conhecimentos. Esse trabalho do pensamento simbólico é marcado por um estilo próprio a cada um, mas que em parte pode ser comum em contextos, escolas ou tradições. Em ciência e em história das ciências, o estilo intervém em dois níveis: o da abordagem "objetal" da produção das obras pelos cientistas e o da abordagem "reflexiva" da história epistemológica e da filosofia, que se interrogam sobre a significação tanto dos próprios conteúdos de conhecimento quanto do pensamento racional, simbólico, cuja função é manifestá-los.By considering scientific knowledge as a form of symbolic thought, we do not mean by the latter simply systems of signs, but thought contents (expressed by concepts related between them and providing meaning ; they are, in the space of mental representations, the substitutes of the «objectively given» that one supposes to underly the experience of the «world» done through the senses and the understanding, both being indissociable at this level. This symbolic thought gets

  10. Badania wytrzymałości resztkowej gruntów spoistych z terenów osuwiskowych okolic Szymbarku k. Gorlic

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    Katarzyna Staromłyńska

    2017-02-01

    Full Text Available W pracy przedstawiono wyniki badań wytrzymałości resztkowej gruntów spoistych pochodzących z terenów osuwiskowych okolic Szymbarku k. Gorlic. Badania przeprowadzone zostały w aparacie bezpośredniego ścinania na próbkach o przekroju 60 × 60 mm. Zastosowano dwie prędkości ścinania 0,05 i 0,1 mm • min–1, każda próbka była ścinana sześciokrotnie, a zakres poziomych odkształceń próbek wynosił 20%. Badania wykazały, że resztkowa wytrzymałość na ścinanie wzdłuż wytworzonej płaszczyzny osłabienia stanowi 52–78% jego wytrzymałości maksymalnej, a do wytworzenia płaszczyzny osłabienia niezbędne jest co najmniej 5-krotne ścinanie próbki. Wpływ prędkości ścinania miał niejednoznaczny wpływ na otrzymane wartości wytrzymałości resztkowej. Wykazano, że stosując do uzyskanych wyników badań liniową interpretację równania Coulomba-Mohra otrzymano niezerowe wartości spójności resztkowej. W związku z tym dla ograniczenia wpływu tego parametru na ocenę stateczności należałoby stosować nieliniową obwiednię wytrzymałościową, do której opisu można zastosować przedstawione w pracy równanie Lade.

  11. Ocena czynności nerek u dzieci leczonych metodę ESWL - doniesienie wstępne

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    Ewa Straż-Żebrowska

    2010-06-01

    Full Text Available Kamica układu moczowego jest chorobą polegającą na tworzeniu się złogów w drogach moczowych w momencie zaburzenia równowagi pomiędzy promotorami i inhibitorami krystalizacji. Obecnie obserwuje się narastanie częstości występowania kamicy w społeczeństwach krajów wysoko uprzemysłowionych, w tym również w populacji dziecięcej. Problem ten dotyczy nawet 5% tej populacji, a coraz większą grupę stanowią dzieci w okresie niemowlęcym. Wśród metod leczenia wyróżniamy postępowanie zachowawcze lub zabiegowe. Leczeniu zachowawczemu najczęściej poddaje się złogi o średnicy do 5 mm, większe wymagają zastosowania metod inwazyjnych. Wśród metod zabiegowych wyróżniamy metody stosunkowo mało inwazyjne, takie jak: ESWL (kruszenie złogów falą generowaną pozaustrojowo, PCNL (przezskóma nefrolitotrypsja, LTRSL (endoskopowa litotrypsja. Obecnie znacznie rzadziej stosowane jest leczenie operacyjne. Zabieg ESWL poprzez działanie fali uderzeniowej powoduje dezintegrację złogu. Cel: Ocena bezpieczeństwa metody w aspekcie funkcji nerek u dzieci leczonych z powodu kamicy układu moczowego metodą ESWL. Materia! i metody: Badaniem objęto 16 dzieci (7 chłopców i 9 dziewczynek w wieku od 2,5 do 17,5 roku (średni wiek 9,5 roku. W ciągu 48 godzin przed wykonaniem zabiegu ESWL oznaczano morfologię krwi, wykładniki stanu zapalnego, stężenie parametrów nerkowych w surowicy (kreatynina, mocznik, cystatyna C, koagulogram. Wyliczano klirensy dla kreatyniny oraz cystatyny C. Mierzono wartości ciśnienia tętniczego. Ponownej oceny czynności nerek w oparciu o te same parametry dokonano w okresie od 1 do 5 miesięcy (średni czas 2,8 miesiąca po zabiegu. Wyniki: Średnie stężenia cystatyny C i kreatyniny oraz wartości klirensów kreatyniny i cystatyny C, mocznika, wartości ciśnienia skurczowego i rozkurczowego nie wykazały istotnych statystycznie różnic przed i po zabiegu ESWL. Stwierdzono statystycznie znamienne

  12. Entre "artes" e "ciências": a noção de performance e drama no campo das ciências socias

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    Rubens Alves da Silva

    2005-12-01

    Full Text Available Propõe-se neste artigo desenvolver uma reflexão teórica que está relacionada com as preocupações e propostas da área de estudos antropológicos das formas expressivas, focalizando, centralmente, a noção de performance e drama no campo das ciências sociais. Nesse sentido é que se busca, no momento, dialogar com os autores considerados representantes principais da discussão teórica em torno da noção de performance, drama e ritual no campo antropológico: Victor Turner, Clifford Geertz, Michael Taussig, Richard Schechner, John Dawsey - entre outros.This article attempts to develop a theoretical reflection on the aims and proposals in the area of the anthropological studies about the expressive forms, dealing with the concept of performance and drama in the social sciences. Taking this into consideration, this work intends to discuss the ideas of the most important authors in the theoretical debate concerning the concept of performance, drama and ritual in the anthropological field: Victor Turner, Clifford Geertz, Michael Taussig, Richard Schechner, John Dawsey - and others.

  13. Analysis of factors affecting the outcome of Graves disease patients treated with two regimens of fixed Iodine-131 doses (10 mCi and 15 mCi)

    International Nuclear Information System (INIS)

    Machado, Ana C.B.; Santos, Roberto B.; Chaves, Fatima R.; Romaldini, Joao H.; Ward, Laura S.

    2005-01-01

    Full text: The use of fixed doses of radioiodine ( 131 I) simplifies the approach to treatment for Graves' disease (GD) patients with potential cost savings. In order to evaluate factors that may affect the outcome of 2 different regimens of 131 I, we prospectively examined 128 patients with overt thyrotoxicosis from GD, as confirmed by suppressed serum TSH, presence of TRAb, increased serum T 3 and FT 4 values. Group 1 comprised 76 patients who received a fixed dose of 10 mCi and Group 2=52 patients who received a fixed dose of 15 mCi. 36 patients did not use any antithyroid drugs and 92 patients used methimazole that was withdrawn at least 5 days before radioiodine administration. Antithyroid drugs treatment was restarted at least 7 days following 131 I therapy when needed. Baseline serum TSH and FT 4 levels were measured at 3, 6, 9 and 12 months after treatment. The groups were similar concerning age, gender, smoke, eye disease, goiter size, serum T 3 , FT 4 , TRAb, anti-Tg and anti-TPO levels as well as 24-hour 131 I or Tec-uptake values and thyroid scan. Clinical outcome was evaluated at the end of 1-year follow-up and cure of hyperthyroidism was defined as clinical and laboratory evidence of either euthyroidism or hypothyroidism in the absence of antithyroid drugs. The cure rate obtained was similar in groups 1 and 2: 73.7% and 80.8%, respectively (p=0.35). Hypothyroidism was diagnosed in 56.5% and 71.15% of the patients from groups 1 and 2, respectively (p=0.13). There was no correlation between clinical features, thyroid uptake, antibodies, serum hormones and outcome. However, logistic regression analysis demonstrated that patients with larger thyroids (weight >60 g) that, consequently, received a lower dose of radioiodine in MBq/g, had 2.4 times less chance to cure (95% Cl=1.18-4.96). The use of fixed doses of radioiodine ( 131 I) simplifies the approach to treatment for Graves' disease (GD) patients with potential cost savings. In order to evaluate

  14. Eccentric knee flexor strength profiles of 341 elite male academy and senior Gaelic football players: Do body mass and previous hamstring injury impact performance?

    Science.gov (United States)

    Roe, Mark; Malone, Shane; Delahunt, Eamonn; Collins, Kieran; Gissane, Conor; Persson, Ulrik McCarthy; Murphy, John C; Blake, Catherine

    2018-05-01

    Report eccentric knee flexor strength values of elite Gaelic football players from underage to adult level whilst examining the influence of body mass and previous hamstring injury. Cross-sectional study. Team's training facility. Elite Gaelic football players (n = 341) from under 14 years to senior age-grades were recruited from twelve teams. Absolute (N) and relative (N·kg -1 ) eccentric hamstring strength as well as corresponding between-limb imbalances (%) were calculated for all players. Mean maximum force was 329.4N (95% CI 319.5-340.2) per limb. No statistically significant differences were observed in relative force values (4.4 N ·kg -1 , 95% CI 4.2-4.5) between age-groups. Body mass had moderate-to-large and weak associations with maximum force in youth (r = 0.597) and adult (r =0 .159) players, respectively. Overall 40% (95 CI 31.4-48.7) presented with a maximum strength between-limb imbalance >10%. Players with a hamstring injury had greater relative maximum force (9.3%, 95% CI 7.0-11.8; p > 0.05) and a 28% (95% CI 10.0-38.0) higher prevalence of between-limb imbalances ≥15% compared to their uninjured counterparts. Overlapping strength profiles across age-groups, combined with greater strength in previously injured players, suggests difficulties for establishing cut-off thresholds associated with hamstring injury risk. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Evaluation of radioiodine therapy with fixed doses of 10 and 15 mCi in patients with Graves disease

    International Nuclear Information System (INIS)

    Canadas, Viviane; Vilar, Lucio; Moura, Eliane; Brito, Ana; Castellar, Enio

    2007-01-01

    The treatment options for the hyperthyroidism of Graves' disease are antithyroid drugs, surgery and radioiodine, none of which is considered ideal, as they do not act directly on the etiopathogenesis of the disease. Radioiodine has been increasingly used as the treatment of choice because it is a safe and definitive therapy whose administration is very easy. Some authors prefer to administer higher doses in order to deliberately induce hypothyroidism, while others recommend lower doses that result in a lower incidence of hypothyroidism and a greater incidence of euthyroidism. There is no consensus for the optimal regimen of fixed doses to be used and this is the main focus of the present study, where doses of 10 and 15 mCi of 131 I were compared. Among the 164 patients analyzed, 61 (37.2%) were submitted to 10 mCi and 103 (62.8%) to 15 mCi. In the longitudinal analysis it was observed that remission of the hyperthyroidism was statistically different in the sixth month (p 131 I brought about a similar remission of the hyperthyroidism after 12 months of treatment. Moreover, the remission rate of the hyperthyroidism had no association with age, sex or previous therapy with antithyroid drugs. (author)

  16. Association of a full-day vs part-day preschool intervention with school readiness, attendance, and parent involvement.

    Science.gov (United States)

    Reynolds, Arthur J; Richardson, Brandt A; Hayakawa, Momoko; Lease, Erin M; Warner-Richter, Mallory; Englund, Michelle M; Ou, Suh-Ruu; Sullivan, Molly

    2014-11-26

    Early childhood interventions have demonstrated positive effects on well-being. Whether full-day vs part-day attendance improves outcomes is unknown. To evaluate the association between a full- vs part-day early childhood program and school readiness, attendance, and parent involvement. End-of-preschool follow-up of a nonrandomized, matched-group cohort of predominantly low-income, ethnic minority children enrolled in the Child-Parent Centers (CPC) for the full day (7 hours; n = 409) or part day (3 hours on average; n = 573) in the 2012-2013 school year in 11 schools in Chicago, Illinois. The Midwest CPC Education Program provides comprehensive instruction, family-support, and health services from preschool to third grade. School readiness skills at the end of preschool, attendance and chronic absences, and parental involvement. The readiness domains in the Teaching Strategies GOLD Assessment System include a total of 49 items with a score range of 105-418. The specific domains are socioemotional with 9 items (score range, 20-81), language with 6 items (score range, 15-54), literacy with 12 items (score range, 9-104), math with 7 items (score, 8-60), physical health with 5 items (score range, 14-45), and cognitive development with 10 items (score range, 18-90). Full-day preschool participants had higher scores than part-day peers on socioemotional development (58.6 vs 54.5; difference, 4.1; 95% CI, 0.5-7.6; P = .03), language (39.9 vs 37.3; difference, 2.6; 95% CI, 0.6-4.6; P = .01), math (40.0 vs 36.4; difference, 3.6; 95% CI, 0.5-6.7; P = .02), physical health (35.5 vs 33.6; difference, 1.9; 95% CI, 0.5-3.2; P = .006), and the total score (298.1 vs 278.2; difference, 19.9; 95% CI, 1.2-38.4; P = .04). Literacy (64.5 vs 58.6; difference, 5.9; 95% CI, -0.07 to 12.4; P = .08) and cognitive development (59.7 vs 57.7; difference, 2.0; 95% CI, -2.4 to 6.3; P = .38) were not significant. Full-day preschool graduates also had higher

  17. CI in the work place: does involving the HRM function make any difference?

    DEFF Research Database (Denmark)

    Hyland, Paul; Becker, Karen; Sload, Terry

    2008-01-01

    benefit the organisation's performance. The HRM function is often given the task of championing cultural change and managing aspects of training and learning, and it would appear that involvement of HRM professionals would enhance CI efforts and assist in the timely solution of issues within the CI......People are central to successful Continuous Improvement (CI), and in larger organisations a Human Resource Management (HRM) function is responsible for people related issues. Central to CI is learning and a culture that supports CI. Learning needs to be both individual and organisational, and must...

  18. As ciências cognitivas e a pesquisa na criação artística e a estética

    Directory of Open Access Journals (Sweden)

    Edmond Couchot

    Full Text Available Este trabalho comenta, num primeiro momento, a história das ciências cognitivas, partindo da cibernética, passando pelo que chamaremos de “cognitivismo”, e, depois, pelo que denominaremos “conexionismo”, e, chegando, enfim, ao momento atual, que é marcado pela multiplicidade das direções de pesquisa, em que se delineia uma forte tendência crítica aos paradigmas anteriores. Num segundo momento, discute-se a influência das ciências cognitivas sobre as teorias da arte e da estética.

  19. O que é Ciência da Informação?

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    Carlos Alberto Ávila Araújo

    2014-12-01

    Full Text Available Introdução: Apresenta um panorama da Ciência da Informação em três momentos. Inicialmente, seu surgimento e consolidação na década de 1960, como confluência de vários fatos: a distinção em relação à Arquivologia, à Biblioteconomia e à Museologia; a relação com a Documentação; a ocupação do espaço institucional da Biblioteconomia; as atividades dos primeiros “cientistas da informação”; as tecnologias da informação; e o uso da Teoria Matemática. Objetivo: Analisar a ampliação vivida nas décadas seguintes com o desenvolvimento de subáreas, das caracterizações do campo e da evolução do conceito de informação. Metodologia: Revisão de Literatura. Resultados: São apresentadas as tendências contemporâneas: as sistematizações da área, os três modelos para o estudo da informação e o desafio recente de diálogo com a Arquivologia, a Biblioteconomia e a Museologia. Conclusões: muitos processos e eventos aconteceram no campo da Ciência da Informação nestes últimos 45 anos. Diferentes subáreas foram formadas, conceitos formulados e reformulados, caracterizações problematizadas e discutidas, relações com outros campos de conhecimento tensionadas e concretizadas.

  20. Trudności we wprowadzaniu reformy gimnazjalnej na obszarach wiejskich

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    Aneta Sobotka

    2016-09-01

    Full Text Available Wprowadzone w 1999 r. gimnazja miały służyć wyrównywaniu szans edukacyjnych dzieci z terenów wiejskich. Jednym z założeń reformy było stworzenie dużych, samodzielnych i dobrze wyposażonych gimnazjów, w których wspólnie uczyliby się absolwenci wszystkich szkół podstawowych z terenu gminy. Po kilkunastu latach funkcjonowania gimnazja pod względem organizacyjnym bardzo się zróżnicowały – w niektórych gminach, zgodnie z założeniami reformatorów, ciągle funkcjonują duże i samodzielne gimnazja, jednak w części gmin bardzo małe gimnazja działają w zespole ze szkołą podstawową, gdzie uczniowie przez dziewięć lat nie zmieniają kolegów, nauczycieli i środowiska. Na podstawie ośmiu studiów przypadku gmin wiejskich pokazano w artykule proces kształtowania sieci gimnazjów w pierwszych latach reformy systemu szkolnego. Próbowano zrozumieć, jakie czynniki zadecydowały o wytworzeniu się tych dwóch modeli gimnazjum. Przedstawione studia przypadku pokazują, że sieć szkolna jest nie tyle wynikiem realizacji planów tworzenia sieci szkolnej przez władze lokalne, ile raczej wynikiem gry pomiędzy lokalnymi władzami a lokalnymi społecznościami.

  1. Nursing domain of CI governance: recommendations for health IT adoption and optimization.

    Science.gov (United States)

    Collins, Sarah A; Alexander, Dana; Moss, Jacqueline

    2015-05-01

    There is a lack of recommended models for clinical informatics (CI) governance that can facilitate successful health information technology implementation. To understand existing CI governance structures and provide a model with recommended roles, partnerships, and councils based on perspectives of nursing informatics leaders. We conducted a cross-sectional study through administering a survey via telephone to facilitate semistructured interviews from June 2012 through November 2012. We interviewed 12 nursing informatics leaders, across the United States, currently serving in executive- or director-level CI roles at integrated health care systems that have pioneered electronic health records implementation projects. We found the following 4 themes emerge: (1) Interprofessional partnerships are essential. (2) Critical role-based levels of practice and competencies need to be defined. (3) Integration into existing clinical infrastructure facilitates success. (4) CI governance is an evolving process. We described specific lessons learned and a model of CI governance with recommended roles, partnerships, and councils from the perspective of nursing informatics leaders. Applied CI work is highly interprofessional with patient safety implications that heighten the need for best practice models for governance structures, adequate resource allocation, and role-based competencies. Overall, there is a notable lack of a centralized CI group comprised of formally trained informaticians to provide expertise and promote adherence to informatics principles within EHR implementation governance structures. Our model of the nursing domain of CI governance with recommended roles, partnerships, and councils provides a starting point that should be further explored and validated. Not only can the model be used to understand, shape, and standardize roles, competencies, and structures within CI practice for nursing, it can be used within other clinical domains and by other informaticians

  2. Self-reported previous knee injury and low knee function increase knee injury risk in adolescent female football

    DEFF Research Database (Denmark)

    Clausen, Mikkel Bek; Tang, L; Zebis, M K

    2016-01-01

    with low KOOS subscale scores (Sport/Recreational (RR: 2.2) and Quality of Life (RR: 3.0) (P time-loss knee...... questionnaires were collected at baseline. Time-loss knee injuries and football exposures were reported weekly by answers to standardized text-message questions, followed by injury telephone interviews. A priori, self-reported previous knee injury and low KOOS subscale scores (... as independent variables in the risk factor analyses. The study showed that self-reported previous knee injury significantly increased the risk of time-loss knee injury [relative risk (RR): 3.65, 95% confidence (CI) 1.73-7.68; P time-loss knee injury was also significantly increased in players...

  3. Escrevendo em aulas de ciências Writing in science classes

    Directory of Open Access Journals (Sweden)

    Carla Marques Alvarenga de Oliveira

    2005-12-01

    Full Text Available Neste artigo, apresentamos uma análise dos registros escritos dos alunos do 3° ano do Ensino Fundamental nas aulas de Ciências, em que a professora utilizou as atividades de conhecimento físico, criadas pelo Laboratório de Pesquisa e Ensino de Física da Faculdade de Educação da Universidade de São Paulo. Os registros analisados foram coletados na Escola de Aplicação da Feusp, no ano de 2001, durante o acompanhamento de três aulas de Ciências: o problema do submarino, o problema do barquinho e o problema da pressão. O artigo procura mostrar um panorama de como aparecem os registros realizados pelos alunos, após uma aula de Ciências em que eles são levados a resolver situações problemáticas por meio da experimentação, argumentar e escrever sobre os fenômenos físicos. Durante a análise, levou-se em consideração os tipos de textos que os alunos escrevem, o uso da primeira pessoa, o uso de verbos de ação, o respeito à ordem cronológica dos eventos e quais os tipos de explicações os alunos atribuem aos fenômenos trabalhados.This article analyzed the written records of Third Grade students of Elementary School at Escola de Aplicação, Universidade de São Paulo, gathered during the Science classes of the 2001 school year, in which activities about physical understanding were used. Created by the Laboratory of Research and Teaching of Physics - LAPEF, of the College of Education of USP, the activities "The Problem of the Submarine", "The Problem of the Little Boat" and "The Problem of the Pressure" required the students to solve problematic situations through experimentation, developing arguments and write about the phenomena. The study developed a framework of how the records are presented by the students, considering the types of texts they produce, the use of the first person, the use of verbs of action, the respect of the chronological order of events and the types of explanations the students give for the

  4. CI therapy is beneficial to patients which chronic low-functioning hemiparesis after stroke

    Directory of Open Access Journals (Sweden)

    Annette eSterr

    2014-10-01

    Full Text Available CI therapy is effective in patients with relatively good levels of residual arm function but its applicability to patients with low functioning hemiparesis is not entirely clear. In the present study we examined the feasibility and efficacy of the CI therapy concept in patients with very limited upper arm function prior to treatment, and further tested how the length of daily shaping training and constraining the good arm affects treatment outcome. In a baseline-controlled design, 65 chronic patients were treated with 2 weeks of modified CI therapy. Patients were randomly allocated to four treatment groups receiving 90 or 180 minutes of daily shaping training applied with or without constraint respectively. Outcome was measured through the Reliable Change Index, which was calculated for parameters of motor function, health and psychological wellbeing. Follow-up data were collected at 6 and 12 months. Two analyses were conducted, a whole-group analysis across all 65 participants and a subgroup analysis contrasting the four treatment variants.The whole-group analysis showed a significant treatment effect, which was largely sustained after one year. The subgroup analysis revealed a mixed picture: while improvements against the baseline period were observed in all four subgroups, 180 minutes of daily shaping training coupled with the constraint yielded better outcome on the MAL but not the WMFT, while for 90 minutes of training the level of improvement was similar for those who wore the constraint and those who did not. Together these results suggest that, at least in those patients available for follow up measures, modified CI therapy induces sustained improvements in motor function in patients with chronic low-functioning hemiparesis. The absence of clear differences between the four treatment variants points to a complex relationship between the length of daily shaping training and the constraint in this patient group which is likely to be

  5. Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP.

    Science.gov (United States)

    Lundby, Alicia; Akemann, Walther; Knöpfel, Thomas

    2010-11-01

    A voltage sensitive phosphatase was discovered in the ascidian Ciona intestinalis. The phosphatase, Ci-VSP, contains a voltage-sensing domain homologous to those known from voltage-gated ion channels, but unlike ion channels, the voltage-sensing domain of Ci-VSP can reside in the cell membrane as a monomer. We fused the voltage-sensing domain of Ci-VSP to a pair of fluorescent reporter proteins to generate a genetically encodable voltage-sensing fluorescent probe, VSFP2.3. VSFP2.3 is a fluorescent voltage probe that reports changes in membrane potential as a FRET (fluorescence resonance energy transfer) signal. Here we report sensing current measurements from VSFP2.3, and show that VSFP2.3 carries 1.2 e sensing charges, which are displaced within 1.5 ms. The sensing currents become faster at higher temperatures, and the voltage dependence of the decay time constants is temperature dependent. Neutralization of an arginine in S4, previously suggested to be a sensing charge, and measuring associated sensing currents indicate that this charge is likely to reside at the membrane-aqueous interface rather than within the membrane electric field. The data presented give us insights into the voltage-sensing mechanism of Ci-VSP, which will allow us to further improve the sensitivity and kinetics of the family of VSFP proteins.

  6. A origem do universo como tema para discutir a Natureza da Ciência no Ensino Médio

    Directory of Open Access Journals (Sweden)

    Gustavo Antonio Montenegro Guttmann

    2015-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n2p442 Nesse artigo, será apresentada uma proposta de introdução de questões relativas à Natureza da Ciência a partir da confrontação de duas teorias distintas sobre a origem do universo. Esse trabalho foi desenvolvido junto a turmas de Ensino Médio de uma escola do Rio de Janeiro. As teorias são divergentes, sendo uma defensora de um universo com uma origem definida, o Big Bang, e a outra de um Universo Eterno. Ao final do trabalho, foi possível aferir que os alunos passaram a ter uma visão mais complexa sobre Ciência.

  7. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial.

    Science.gov (United States)

    Shaverdian, Narek; Lisberg, Aaron E; Bornazyan, Krikor; Veruttipong, Darlene; Goldman, Jonathan W; Formenti, Silvia C; Garon, Edward B; Lee, Percy

    2017-07-01

    months (IQR 29·8-34·1). Progression-free survival with pembrolizumab was significantly longer in patients who previously received any radiotherapy than in patients without previous radiotherapy (hazard ratio [HR] 0·56 [95% CI 0·34-0·91], p=0·019; median progression-free survival 4·4 months [95% CI 2·1-8·6] vs 2·1 months [1·6-2·3]) and for patients who previously received extracranial radiotherapy compared with those without previous extracranial radiotherapy (HR 0·50 [0·30-0·84], p=0·0084; median progression-free survival 6·3 months [95% CI 2·1-10·4] vs 2·0 months [1·8-2·1]). Overall survival with pembrolizumab was significantly longer in patients who previously received any radiotherapy than in patients without previous radiotherapy (HR 0·58 [95% CI 0·36-0·94], p=0·026; median overall survival 10·7 months [95% CI 6·5-18·9] vs 5·3 months [2·7-7·7]) and for patients who previously received extracranial radiotherapy compared with those without previous extracranial radiotherapy (0·59 [95% CI 0·36-0·96], p=0·034; median overall survival 11·6 months [95% CI 6·5-20·5] vs 5·3 months [3·0-8·5]). 15 (63%) of 24 patients who had previously received thoracic radiotherapy had any recorded pulmonary toxicity versus 29 (40%) of 73 patients with no previous thoracic radiotherapy. Three (13%) patients with previous thoracic radiotherapy had treatment-related pulmonary toxicity compared with one (1%) of those without; frequency of grade 3 or worse treatment-related pulmonary toxicities was similar (one patient in each group). Our data suggest that previous treatment with radiotherapy in patients with advanced NSCLC results in longer progression-free survival and overall survival with pembrolizumab treatment than that seen in patients who did not have previous radiotherapy, with an acceptable safety profile. Further clinical trials investigating this combination are needed to determine the optimal treatment strategy for patients with advanced

  8. Możliwości polderyzacji obszaru zawala w rejonie Stężycy nad Wisłą

    Directory of Open Access Journals (Sweden)

    Anna Sosnowska

    2016-12-01

    Full Text Available Temat ochrony przeciwpowodziowej, w tym polderów, jest zwykle podnoszony przy okazji każdej większej powodzi i po pewnym czasie, gdy zastosowano już doraźne środki naprawcze, dyskusja cichnie. Poldery jako obiekty hydrotechniczne, mające za zadanie przejąć szczyt fali powodziowej, wzbudzają wiele przeciwstawnych emocji. Z jednej strony uważa się, że są to obiekty, które mogą skutecznie uzupełniać system ochrony przeciwpowodziowej i pozytywnie wpływać na środowisko przyrodnicze. Z drugiej strony wysokie koszty, niska efektywność i wiele innych elementów sprawiają, że nie jest to popularna forma ochrony przed powodzią. W części obliczeniowej pracy skupiono się na nieistniejącym polderze w Stężycy o całkowitej pojemności równej około 24 mln m3. Model odcinka Wisły z uwzględnieniem istnienia polderu wykonano w programie HEC-RAS. Obliczenia dotyczyły szybkości napełniania tego zbiornika przy trzech różnych wariantach przepływu nieustalonego i przy różnych długościach przelewu na wlocie do polderu. Symulacje wykazały, że w krytycznym przypadku niezbędny byłby wlot o długości ok. 400 m, aby w całości napełnić polder podczas trwania wezbrania. W drugiej części pracy podjęto dyskusję na temat pozytywnych i negatywnych aspektów budowy polderów.

  9. The configuration-driven table CI method and comparison with integral-driven CI procedures

    International Nuclear Information System (INIS)

    Buenker, R.J.

    1980-01-01

    A new configuration-driven CI algorithm is outlined which eliminates the need for explicit comparison of pairs of Slater determinants through the use of a series of compact tables. In this scheme each pair of configurations is either shown to be non-interacting or to fall into one of nine cases, each of which is characterized fully once certain orbital permutations are determined. The program is divided into three parts: a case structure analysis step including integral label generation, a sort of the required electron repulsion integrals, and finally a procedure in which the foregoing information is combined with tabulated directions for the evaluation of the necessary Hamiltonian matrix elements over spin-adapted functions. Timing improvements of up to more than a factor of four have been achieved with the new algorithm

  10. Jaką teorią jest Marksowska teoria wartości opartej na pracy?

    Directory of Open Access Journals (Sweden)

    Krzysztof Nowak-Posadzy

    2015-12-01

    Full Text Available Tak zwana teoria wartości opartej na pracy (odtąd LTV, niegdyś powód do dumy całego środowiska marksistowskiego, stawała się z upływem lat przedmiotem jego zakłopotania. Jej odrzucenie w ramach tradycji lewicowej, zarówno przez część filozofów, jak i ekonomistów, wpisuje się w szersze zjawisko zwane „kryzysem marksizmu”. Wówczas to filozoficzna część środowiska marksistowskiego, chcąc uwolnić marksizm od wad „ekonomizmu”, odcięła go także od zalet mogących płynąć z przyjęcia perspektywy ekonomii teoretycznej. Natomiast część ekonomiczna przywołanego środowiska, chcąc uwolnić ekonomię marksistowską od niedociągnięć tkwiących w LTV, odcięła ją także od szczególnego statusu przypisywanego w tej tradycji intelektualnej pojęciu pracy. Chociaż uniewinniono później LTV od zarzutu o domniemaną logiczną sprzeczność, to jedynie po to, aby skazać ją następnie na zapomnienie za jej rzekomą zbyteczność. W niniejszym artykule omówiona zostanie specyfika Marksowskiej wersji LTV. We wstępie podane zostaną cztery jakościowe założenia, które, zdaniem autora, przesądzają o charakterze Marksowskiej wersji LTV, W pierwszej części zarysowane zostanie miejsce LTV w historii myśli ekonomicznej. Druga część dotyczyć będzie losów Marksowskiej wersji LTV w ramach samej tradycji marksistowskiej. W trzeciej części omówiony zostanie problem wartości i jej pomiaru. Czwarta część zostanie poświęcona analizie problemu pracy i wyboru jednostki jej pomiaru, a także próbie zrekonstruowania Marksowskiej teorii reprodukcji pracowników za pomocą pracy. W części piątej podjęta zostanie kwestia tego, jak interpretuje się współcześnie status metodologiczny marksowskiej wersji LTV. Artykuł kończy podsumowanie.

  11. Podstawowe zasady postępowania w przebiegu chorób układu pokarmowego u kobiet w ciąży

    Directory of Open Access Journals (Sweden)

    Ewa Tylec-Osóbka

    2012-12-01

    Full Text Available Chociaż ciąża jest stanem fizjologicznym, to jednak kobiety ciężarne często wymagają diagnostyki i leczenia z powodu poważnych zaburzeń ze strony przewodu pokarmowego. Zwykle są one najczęściej zgłaszanymi dolegliwościami klinicznymi w przebiegu ciąży. U części kobiet pojawiają się zaburzenia specyficzne dla ciąży. Inne ciężarne, z przewlekłymi chorobami przewodu pokarmowego, wymagają specjalnego postępowania w tym okresie. Zrozumienie przebiegu i chorobowości różnorodnych zaburzeń przewodu pokarmowego jest niezbędne, by zoptymalizować opiekę nad tymi pacjentkami. Ciąża ma niewielki wpływ na wydzielanie i wchłanianie, ale wpływa istotnie na motorykę przewodu pokarmowego. Te zaburzenia motoryki są związane z podwyższonym stężeniem żeńskich hormonów płciowych. Dodatkowo powiększająca się macica przemieszcza jelita, co jest przyczyną powszechnych dolegliwości, jakimi są zaparcia. Wiedza na temat mechanizmów adaptacyj‑ nych przewodu pokarmowego w czasie ciąży umożliwia prawidłową interpretację testów laboratoryjnych i badań obrazowych u ciężarnych. Rzadko konieczne jest wykonywanie badań endoskopowych w ciąży. Poten‑ cjalne ryzyko wynikające z endoskopii to niedotlenienie płodu powodowane lekami sedatywnymi oraz ekspo‑ zycja na promieniowanie rentgenowskie. Nie stwierdzono, by badania endoskopowe wywoływały wcześniejsze porody, a obserwacje potwierdzają, że endoskopia w czasie ciąży jest generalnie bezpieczna, przy zachowaniu określonych standardów. Badania powinno się wykonywać w przypadku mocnych wskazań, jeśli to możliwe – w drugim trymestrze ciąży. Procedury najlepiej wykonywać bez sedacji lub z użyciem najmniejszych dawek leków, minimalizując czas ekspozycji na fluoroskopię, optymalnie w obstawie anestezjologicznej i położniczej.

  12. Ciénaga (Magdalena, una región administrativa o municipio de enclave

    Directory of Open Access Journals (Sweden)

    Luis Humberto Hernández

    2006-01-01

    Full Text Available El análisis sobre las regiones de enclave, el caso del municipio de Ciénaga, en el Magdalena, nos permitió concluir que su proceso de modernización estuvo determinado por la presencia de la empresa multinacional bananera United Fruit Company. La multinacional bananera fue la que introdujo en la región el trabajo asalariado moderno, dislocando las formas serviles y premodernas existentes. Al atraer la mano de obra servil regional, que utilizaban las haciendas ganaderas, y convertirla en mano de obra asalariada, fundamentó sus procesos socioeconómicos y político administrativo modernos.

  13. Concepções de ciência presentes na divulgação e prática de instituições não formais de ensino de ciências

    OpenAIRE

    Thayse Zambon Barbosa Aragão

    2013-01-01

    Esse trabalho tem como objetivo apresentar quais concepções de ciência estão presentes no discurso e prática de instituições de educação não formal. Para tanto investigaram-se quatro importantes instituições brasileiras integrantes deste universo, escolhidas a partir de indicações de seus pares: Museu da Vida (RJ), Espaço Ciência (PE), Museu de Ciência e Tecnologia da PUCRS (RS) e Estação Ciência (SP). Foram analisados os sites dessas instituições, utilizando-se como metodologia a análise ...

  14. Impact of Availability and Use of ART/PMTCT Services on Fertility Desires of Previously Pregnant Women in Rakai, Uganda: A Retrospective Cohort Study.

    Science.gov (United States)

    Litwin, Lindsay E; Makumbi, Frederick E; Gray, Ronald; Wawer, Maria; Kigozi, Godfrey; Kagaayi, Joseph; Nakigozi, Gertrude; Lutalo, Tom; Serwada, David; Brahmbhatt, Heena

    2015-07-01

    To assess fertility desires by availability and use of antiretroviral therapy and prevention of mother-to-child transmission (ART/PMTCT) services in Rakai, Uganda. Retrospective analyses of longitudinal data from the Rakai Community Cohort Study. Study participants were retrospectively identified and categorized by HIV status. Availability of ART/PMTCT services in Rakai was defined in three periods: (1) pre-ART/PMTCT (ART/PMTCT rollout (2005-2006), and (3) universal ART/PMTCT (>2006); and use of ART/PMTCT was coded as yes if the woman received services. Trends in fertility desires were assessed by χ. "Modified" Poisson regression was performed using generalized linear models with a log link and Poisson family to estimate prevalence rate ratios (PRRs) and 95% confidence intervals (CIs) of desire for another child among previously and currently pregnant women; PRRs were adjusted for demographic and behavioral factors. A total of 4227 sexually active women in Rakai, including 436 HIV+ women, contributed 13,970 observations over 5 survey rounds. Fertility desires increased in the population in the ART/PMTCT rollout [adjusted (adj.) PRR: 1.08, 95% CI: 1.04 to 1.13] and the universal availability periods (adj. PRR: 1.11, 95% CI: 1.08 to 1.14) compared with pre-ART/PMTCT period. A total of 862 woman observations used ART/PMTCT services. Fertility desires were similar among ART/PMTCT service users and nonusers in cross-sectional analysis (adj. PRR: 0.84, 95% CI: 0.62 to 1.14) and 1 year after ART/PMTCT use (adj. PRR: 1.27, 95% CI: 0.83 to 1.94). Availability of ART/PMTCT may increase fertility desires of previously pregnant women in Rakai, Uganda. Use of ART/PMTCT services was not correlated with fertility desires of previously or current pregnant women.

  15. Ciência e Direitos Humanos: direitos culturais e maternidade

    OpenAIRE

    Lopes, Allice Ferreira; Gomes, Ana Lucia de Abreu

    2018-01-01

    O objetivo desse artigo é analisar a ligação entre ciência e cultura bem como seu impacto entre as mulheres, especialmente durante a maternidade, destacando a recente conquista dos espaços públicos. Foi realizado levantamento bibliográfico sobre o tema dos Direitos Humanos das Mulheres e a visão sobre as mulheres na Ciência. Posteriormente é apresentada pesquisa sobre legislações e normativas disponíveis nos portais virtuais do Instituto do Patrimônio Histórico e Artístico Nacional, com desta...

  16. Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy.

    Science.gov (United States)

    Heo, Mi Hwa; Kim, Hee Kyung; Lee, Hansang; Kim, Ji-Yeon; Ahn, Jin-Seok; Im, Young-Hyuck; Park, Yeon Hee

    2018-03-16

    We conducted a retrospective analysis of the clinical activity of fulvestrant in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) previously treated with endocrine therapy and/or chemotherapy. We reviewed the medical records of all patients with MBC treated at Samsung Medical Center between January 2009 and August 2016. Patients received fulvestrant 250 mg intramuscularly every 28 days (from January 2009 to November 2010) or 500 mg intramuscularly every 28 days (from December 2010 to August 2016). Tumor responses were assessed every 8 weeks and at the end of treatment, as well as when disease progression was suspected. A total of 84 patients were included in this study. A median of two previous endocrine treatments had been performed; 79% of the patients had received two or more endocrine treatments. Forty-five patients (54%) had been treated with chemotherapy for MBC before the fulvestrant treatment course. Visceral metastasis was found in 49 patients (58%). The estimated median progression-free survival and overall survival were 4.4 months (95% confidence interval [CI], 3.4 to 5.5) and 32.5 months (95% CI, 17.6 to 47.4), respectively. The disease control rate was 40.5% (95% CI, 30.5 to 51.5); partial response was observed in 16% of the patients and stable disease was observed in 25% of the patients. The most frequently reported adverse reactions were mild-to-moderate grade myalgia (10.5% of the patients), injection site pain (7%), and fatigue (7%). Fulvestrant was generally well tolerated. Fulvestrant showed encouraging clinical activity and favorable feasibility in postmenopausal women with MBC who had been treated with multiple endocrine therapies and/or cytotoxic chemotherapies.

  17. História da Ciência: objetos, métodos e problemas History of Science: purposes, methods and problems

    Directory of Open Access Journals (Sweden)

    Lilian Al-Chueyr Pereira Martins

    2005-08-01

    Full Text Available O objetivo deste artigo é auxiliar o trabalho de pessoas que estão se iniciando na pesquisa de História da Ciência, especialmente em relação a um determinado tipo de trabalho a que nos dedicamos. Este tratará da escolha de um tema adequado de pesquisa, dos tipos de fontes encontradas em História da Ciência e de alguns problemas encontrados em trabalhos de História da Ciência. Este estudo levou à conclusão de que só se apreende a fazer pesquisa em História da Ciência a partir da prática e que um bom historiador da ciência se constrói a longo prazo.The aim of this paper is to help people who are starting History of Science research, especially concerning a definite kind of work to which we dedicate ourselves. It deals with the choice of a suitable research subject, the kinds of sources in History of Science, as well as some problems which may be found in the works on History of Science. This study leads to the conclusion that beginners learn how to do History of Science research through the praxis and that a person becomes a good historian of science in the long term.

  18. The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.

    Science.gov (United States)

    Sadatsafavi, Mohsen; Xie, Hui; Etminan, Mahyar; Johnson, Kate; FitzGerald, J Mark

    2018-01-01

    There is minimal evidence on the extent to which the occurrence of a severe acute exacerbation of COPD that results in hospitalization affects the subsequent disease course. Previous studies on this topic did not generate causally-interpretable estimates. Our aim was to use corrected methodology to update previously reported estimates of the associations between previous and future exacerbations in these patients. Using administrative health data in British Columbia, Canada (1997-2012), we constructed a cohort of patients with at least one severe exacerbation, defined as an episode of inpatient care with the main diagnosis of COPD based on international classification of diseases (ICD) codes. We applied a random-effects 'joint frailty' survival model that is particularly developed for the analysis of recurrent events in the presence of competing risk of death and heterogeneity among individuals in their rate of events. Previous severe exacerbations entered the model as dummy-coded time-dependent covariates, and the model was adjusted for several observable patient and disease characteristics. 35,994 individuals (mean age at baseline 73.7, 49.8% female, average follow-up 3.21 years) contributed 34,271 severe exacerbations during follow-up. The first event was associated with a hazard ratio (HR) of 1.75 (95%CI 1.69-1.82) for the risk of future severe exacerbations. This risk decreased to HR = 1.36 (95%CI 1.30-1.42) for the second event and to 1.18 (95%CI 1.12-1.25) for the third event. The first two severe exacerbations that occurred during follow-up were also significantly associated with increased risk of all-cause mortality. There was substantial heterogeneity in the individual-specific rate of severe exacerbations. Even after adjusting for observable characteristics, individuals in the 97.5th percentile of exacerbation rate had 5.6 times higher rate of severe exacerbations than those in the 2.5th percentile. Using robust statistical methodology that controlled

  19.  Praktyczna realizacja Programu zapewnienia i poprawy jakości w komórkach audytu wewnętrznegona wybranych przykładach

    Directory of Open Access Journals (Sweden)

    ANNA BARTOSZEWICZ

    2015-03-01

    Full Text Available  Celem niniejszego artykułu jest zaprezentowanie praktycznej strony realizacji Programu zapewnienia i poprawy jakości przez audytorów wewnętrznych. Na podstawie wyników badań ankietowych dokonano analizy wykonania przez audytorów przedmiotowego zagadnienia. Wskazuje ona na stosowanie przez badaną grupę audytorów różnych form realizacji Programu zapewnienia i poprawy jakości, a także informuje, że efektywna realizacja standardu 1300 IIA daje kierownikowi jednostki zapewnienie o prawidłowości funkcjonowania audytu w danym podmiocie oraz gwarancję, że audyt wewnętrzny działa zgodnie z międzynarodowymi standardami.

  20. A biblioteca do ensino intuitivo e o ensino de ciências na escola primária brasileira: 1880-1900

    Directory of Open Access Journals (Sweden)

    Karl Michael Lorenz

    2007-06-01

    Full Text Available O trabalho discute a importância do ensino de Ciências na escola primária brasileira no último quartel do século XIX, tendo como foco de análise os livros didáticos de Ciências que surgiram depois da reforma educacional de 1878, do Ministro Carlos Leôncio de Carvalho, e o Parecer de 1883, de Rui Barbosa. O trabalho relata primeiro as idéias prevalecentes no exterior e debatidas no  Brasil sobre o papel e a maneira de ensinar as ciências na escola primária. Segue com uma discussão de livros-didáticos de Ciências Naturais divulgados no Brasil, e, particularmente, da coletânea de livros intitulada Biblioteca do Ensino Intuitivo — As Sciencias Naturaes. Os livros, destinados  para o ensino primário, foram escritos por eminentes autores ingleses e publicados na Inglaterra e nos Estados Unidos sob o título Science Primers. A coletânea foi traduzida para o português e adaptada para o ensino brasileiro na década de 1880 e 1890.

  1. Rak piersi w ciąży - odmienności procesu diagnostyki i leczenia = Breast cancer during pregnancy - differences in diagnostic and treatment procedures

    Directory of Open Access Journals (Sweden)

    Magdalena Sowa

    2016-09-01

    85 -801 Bydgoszcz e – mail: magdalena.sowa@cm.umk.pl         Streszczenie Wprowadzenie: Rak piersi w ciąży jest rozpoznawany stosunkowo rzadko. W ostatnich dziesięciu latach w Europie można zauważyć wyraźną tendencję do odraczania macierzyństwa wśród młodych kobiet. Obecnie średnia wieku kobiet rodzących pierwsze dziecko wynosi 30 lat. Jednym z czynników ryzyka zachorowania na raka piersi jest wiek. Z uwagi na fakt, iż kobiety coraz później decydują się na macierzyństwo, a średnia wieku występowania raka piersi się obniża,  z tą szczególną sytuacją kliniczną lekarzom jak i kobietom przyjdzie się zmagać coraz częściej.  Cel pracy:Celem pracy była próba przybliżenia odmienności procesu diagnostyki i leczenia raka gruczołu piersiowego rozpoznanego w ciąży. Rozwinięcie:Z danych epidemiologicznych wynika, iż rak piersi jest najczęściej występującym nowotworem u kobiet ciężarnych.Szczególnie niebezpiecznym jest fakt, iż zmiany fizjologicznie zachodzące w organizmie kobiety już od pierwszych tygodni ciąży, mogą maskować pojawienie się guza i znacznie opóźniać wdrożenie procesu diagnostyki.  Choroba nowotworowa rozpoznana w czasie trwania ciąży jest zawsze dramatyczną i ogromnie stresującą sytuacją dla kobiety i jej najbliższych, dlatego proces diagnostyki i leczenia jest silnie zindywidualizowany, zaś maksymalny efekt terapeutyczny z jednoczesną ochroną nienarodzonego dziecka stanowi priorytet działań. Podsumowanie:Decyzje terapeutyczne podejmowane są po uwzględnieniu ogólnego stanu zdrowia pacjentki, stopnia zaawansowania klinicznego nowotworu, wieku ciążowego oraz postulatów samej pacjentki i jej najbliższych.W niniejszej pracy, posługując się metodą analizy piśmiennictwa szczegółowo omówiono odmienności w procesie diagnostyki i leczenia raka piersi u kobiet ciężarnych.   Słowa kluczowe: rak piersi, ciąża, diagnostyka, leczenie   Breast cancer during pregnancy

  2. Deciding on the mode of birth after a previous caesarean section - An online survey investigating women's preferences in Western Switzerland.

    Science.gov (United States)

    Bonzon, Magali; Gross, Mechthild M; Karch, André; Grylka-Baeschlin, Susanne

    2017-07-01

    promoting vaginal births after caesarean section (VBAC) for eligible women and increasing rates of successful VBACs are the best strategies to reduce the number of repeat caesarean sections (CS). Knowledge of factors that are associated with women's decision-making around mode of birth after CS is important when developing strategies to promote VBAC. This study assessed which factors are associated with women's preferences for VBAC versus elective repeat caesarean section (ERCS) in a new pregnancy after one previous caesarean in Switzerland. cross-sectional web-survey. Western Switzerland. French-speaking women living in Western Switzerland, with one previous CS who gave birth subsequently to a child after a complication-free pregnancy were eligible to participate in the survey. Of 393 women who started the survey in November/December 2014, 349 were included: 227 who planned a VBAC and 122 who planned an ERCS at term. univariable and multivariable analyses were conducted to describe and compare women who had planned a VBAC with women who had planned an ERCS in a pregnancy following a CS. Logistic regression modelling was used to investigate predictors that were associated with a preference for a VBAC at term. Analyses were performed with SPSS 22 and Stata 13. of the women planning a VBAC, 62.6% VBAC gave birth vaginally. Predictors which were significantly associated with increased odds of women choosing a VBAC: duration since previous birth in years (OR=1.11 95% CI [1.03-1.20], p=0.010), having had midwifery care during pregnancy (OR=2.09, 95% CI [1.08-4.05], p=0.029), being advised by their healthcare provider to attempt a VBAC (OR=4.20, 95% CI [1.75-10.09], p=0.001), preference for VBAC during the third trimester of their pregnancy (OR=3.98, 95% CI [1.77-8.93], p=0.001), and wishing to let the child choose the moment of birth (OR=1.46, 95% CI[1.22-1.74], p<0.001). The importance of safety for the mother decreased the odds of women preferring a VBAC (OR=0.74, 95

  3. A metafísica na ciência moderna: uma discussão heideggeriana

    Directory of Open Access Journals (Sweden)

    Flávio Oliveira Silva

    2015-07-01

    Full Text Available O artigo apresenta duas teses de Heidegger: a interpretação da Crítica da Razão Pura como metafísica e a afirmação da permanência da metafísica na ciência moderna. Em seguida analisa as objeções que Loparic apresenta a essas teses no artigo A metafísica e o processo de objetificação,para enfim argumentar que suas contestações não se sustentam. Loparic afirma que  a Crítica da Razão Pura não se destina a investigar a quididade dos entes, mas as condições nas quais os juízos sintéticos a priori podem ser verdadeiros ou falsos, de modo que o problema tratado por Kant não seria ontológico, mas semântico. Loparic afirma ainda que a ciência moderna deixou o quadro ontológico da metafísica aristotélica, na medida em que não mais se destina a estudar os entes como tais, isto é, como uma coisa em si, mas tão somente investigar a resposta da natureza, mediante intervenção técnica no curso dos processos naturais e, portanto não há sequer resquício da metafísica na ciência moderna. Essas objeções apresentam dificuldades na medida em que o autor se utiliza do conceito tradicional de metafísica para tratar da filosofia de Heidegger. Argumenta-se que o sentido de metafísica para Heidegger não se restringe à concepção de metafísica da tradição, de modo que, constitui um equívoco analisar as teses heideggerianas em conformidade com a leitura da tradição.  Heidegger se pauta na indicação de que Kant se ocupa das condições de possibilidade da compreensão, isto é, do Dasein, enquanto o ente que coloca a pergunta sobre o ser e é nesta dimensão que a Crítica da Razão Pura é recepcionada como metafísica. No tocante à ciência, o filósofo afirma que, mesmo a ciência moderna tendo abandonado a representação de objetos, ela não renunciou e nem poderia renunciar à necessidade de a natureza fornecer dados que se possa calcular e de continuar sendo um sistema disponível de informação, de modo

  4. Comparative evaluation of the two methods of fixed dose radioiodine therapy (5 mCi and 10 mCi) for the treatment of Graves' disease

    International Nuclear Information System (INIS)

    Fard Esfehani, A.; Dabbagh Kakhki, V.R.; Eftekhari, M.; Zarpak, B.; Fallahi Seyjani, B.; Saghari, M.

    2002-01-01

    Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment in most patients with Graves' disease. Due to complexity of methods for dose determination, the tendency is toward using fixed doses of I-131 for this purpose. As there is conflict for the best fixed dose, regarding it's efficiency and complication of hypothyroidism, standardized dose selection is of particular importance in treatment of Grave' disease. 59 patients with grave' disease, referred to the nuclear medicine center of Shariati Hospital from 78.5.25 were studied. In this clinical trial, the patients were randomized into two groups, one were treated with 5 mCi of 1-131 and the other received 10 mCi of the same agent. All patients were followed for two years, with 6-month intervals. Among 65 patients treated with I-131, 20 (33 9%) patients became euthyroid and 19(32.2%) became hypothyroid while relapse was noticed in 20 patients (33.9%) In The group treated by 5 mCi I-131 (33 patients), 10(30%) were euthyroid, 6(18.2%) were hypothyroid (overall cure of 48.5% while 17(51.5%) remained hyperthyroid by the end of the follow -up period(two years). From the 26 patients who were treated with 10 mCi, the euthyroid, hypothyroid and hypothyroid states were observed in 10(38.5%), 13(50%), 13(50%) and 3(11.5%) patients respectively (with an overall cure rate of 88.5%). No relationship was noted between the outcome and age, sex, size of the thyroid gland and thyroid uptake, but the relationship between the disease outcome and the amount of administered radioiodine was statistically significant (P=0.003). For most of the patients, age, sex, iodine uptake and even thyroid size play minor roles in dose selection. Although the incidence-rate of early hypothyroidism (by the end of 2 years) in the cases related with 5 mCi is less than those treated with 10 mCi, the incidence of relapse is greatly higher in the former group. In addition, it was found that long

  5. Quantitative detection of RO2 radicals and other products from cyclohexene ozonolysis with ammonium-CI3-TOF and acetate-CI-API-TOF

    Science.gov (United States)

    Hansel, A.; Scholz, W.; Mentler, B.; Fischer, L.; Berndt, T.

    2017-12-01

    The performance of the novel ammonium-CI3-TOF utilizing NH4+ adduct ion chemistry to measure quantitatively first generation oxidized product molecules (OMs) as well as highly oxidized organic molecules (HOMs) was investigated for the first time. The gas-phase ozonolysis of cyclohexene served as a test system in order to evaluate the capability of the detection systems. Experiments have been carried out in the TROPOS free-jet flow system at close to atmospheric conditions. Product ion signals were simultaneously observed by the ammonium-CI3-TOF and the acetate-CI-API-TOF. Both instruments are in remarkable good agreement within a factor of two for HOMs. For OMs not containing an OOH group the acetate technique can considerably underestimate OM concentrations by 2-3 orders of magnitude. First steps of cyclohexene ozonolysis generate ten different (m/z product peaks) main products comprising 92% of observed OMs. The remaining 8% are distributed over several (m/z peaks) minor products that can be attributed to HOMs, predominately to highly oxidized RO2 radicals. Summing up, observed ammonium-CI3-TOF products yield 4.9 x 109 molecules cm-³ in excellent agreement with the amount of reacted cyclohexene of 5.0 x 109 molecules cm-³ for reactant concentrations of [O3] = 2.25 x 1012 molecules cm-³ and [cyclohexene] = 2.0 x 1012 molecules cm-³ and a reaction time of 7.9 s. NH4+ adduct ion chemistry based CIMS techniques offer a unique opportunity for complete detection of the whole product distribution, and consequently, for a much better understanding of atmospheric oxidation processes.

  6. Uma abordagem sociológica da sociologia: a ciência como campo

    Directory of Open Access Journals (Sweden)

    Vívian Matias dos Santos

    2012-03-01

    Full Text Available O presente ensaio objetiva analisar como o conceito de campo de Pierre Bourdieu pode contribuir para uma abordagem sociológica da Sociologia. A discussão desdobra-se desde a reflexão mais geral de como se firma a ciência até as possibilidades de compreensão da Sociologia neste espaço. Para tanto, fez-se necessário abordar o “campo científico” por meio das relações entre sua estrutura e seus agentes - relações “multidimensionais” que podem representar uma exitosa tentativa de superação da dicotomia ação/estrutura; indivíduo/sociedade; micro e macroteorização.

  7. A comunicação nas ciências da linguagem

    Directory of Open Access Journals (Sweden)

    Geraldo Carlos do Nascimento

    2002-06-01

    Full Text Available Este trabalho situa a questão da comunicação na sua vertente relacionada com as ciências da linguagem, que ganham corpo, embora suas origens remontem a Saussure, a partir do ensaio de Roman Jakobson, Linguistic and Poetics (1960, no qual é apresentado um esquema básico da comunicação. As fragilidades deste esquema, ainda vinculado às noções da sociologia funcionalista (Laswell/Scharam, logo se fizeram notar, particularmente no que se refere à sua operacionalização; mas foi a partir de sua crítica, conforme se defende aqui, que a semiótica greimasiana pôde, ao articular comunicação e sentido, estabelecer bases mais consistentes para a discussão da noção de comunicação e se seu campo presumível.

  8. FDG PET/CT in pediatric primary bone tumours: comparison with conventional imaging (CI) and management impact assesment

    International Nuclear Information System (INIS)

    Stege, Claudia; London, Kevin; Cross, Siobhan; Howman-Giles, Robert; Onikul, Ella; Graf, Nicole; Pozza, L.D.

    2009-01-01

    Full text: To evaluate PET/CT in pediatric primary bone tumours (PBT), the accuracy, clinical impact, prognostic indicators in predicting tumour response to therapy and determining epiphyseal involvement were compared to Cl. Methods: A retrospective review of PET/CT scans with CI was performed. Lesions were compared to a reference standard: histopathology or follow up >6 mths. Pt based analysis was performed for clinical impact. Prognostic indicators (SUYmax, tumour size) were compared to histopathology response post chemotherapy. Results: 43 pts (average 12.9 yrs) with osteosarcoma (I 8), Ewing's sarcoma (21), PNE (4) were analysed. 109 PET/CT scans with CI scans were evaluated (371 lesions). 33 lesions were discordant. Accuracy of PET/CT was higher for all lesions than CI (95% vs92%) but sensitivity was lower (79% vs 83%). Excluding lung lesions, sensitivities increased for PET/CT and CI (92% vs 89%). 9pts had PET/CT staging and follow up with histopathological evaluation post chemotherapy: 2pts poor responders, 7 good responders. Good responders had a higher SUYmax at diagnosis compared to poor responders (av 13.84 vs 7.95) but reduced more [10.5(70%) vs 3.5( 45%)]following chemotherapy. There were no false negatives for epiphyseal involvement for PET/CT and CI but one PET/CT was false positive. Conclusion: PET/CT is less sensitive in small lung lesions, but more sensitive in other areas compared to Cl. SUYmax at diagnosis is a poor predictor of response, but percent decrease post therapy was associated with therapeutic response. Change in tumour size on MR is a poor predictor of response. There is improved clinical impact with PET/CT in patient management.

  9. Identyfikacja wielokryterialnego modelu istotności pompowni melioracyjnych na terenie Polski

    OpenAIRE

    Wojciech Sałabun; Michał Napierała; Jerzy Bykowski

    2015-01-01

    Niniejsza praca omawia istotny problem związany z klasyfikacją i właściwym zdefiniowaniem wielkości pompowni melioracyjnych. Podstawowa definicja wielkości jest bardzo szeroka, zatem ze względu na liczbę objaśniających ją parametrów wymaga precyzyjnego uściślenia. W dotychczasowych ocenach rozmiarów pompowni melioracyjnych posługiwano się na ogół wrażeniami osobistymi opartymi na subiektywnym odczuciu, które z kolei jest oparte na nieznanej liczbie parametrów. Pojawiające się przy...

  10. Martwica kości szczęk związana ze stosowaniem bifosfonianów. Opis przypadków

    Directory of Open Access Journals (Sweden)

    Wojciech Leśniak

    2013-06-01

    Full Text Available Bifosfoniany należą do silnych inhibitorów osteoklastów. Znajdują szerokie zastosowanie w leczeniu chorób przebiegających ze wzmożoną resorpcją kości: osteoporozy, choroby Pageta i osteogenesis imperfecta. Leki te zmniejszają adhezję komórek nowotworowych do kości, ograniczają osteolizę wywołaną nowotworem i hiper‑ kalcemię. Zmniejszają dolegliwości bólowe w szpiczaku mnogim i w przerzutach do kości. Powszechnie panu‑ jące przekonanie o bezpieczeństwie spowodowało rozszerzenie wskazań do ich stosowania. Pacjenci onkolo‑ giczni przyjmujący bifosfoniany dożylnie, w wysokich dawkach są bardziej narażeni na działania niepożądane terapii niż pacjenci przyjmujący je doustnie. Jednym z najpoważniejszych powikłań jest martwica kości szczęk. W 2003 roku opisano po raz pierwszy związek pomiędzy terapią bifosfonianami a martwicą kości szczęk. W piśmiennictwie znajdujemy coraz więcej przykładów tego działania niepożądanego, także po stosowaniu leków doustnie. Mogą pojawiać się ból, obrzęk, owrzodzenie, odsłonięcie kości, przetoki, złamania patologiczne, uciążliwe dla pacjenta i obniżające jakość życia. Leczenie martwicy kości szczęk jest trudne i rzadko przynosi spodziewany efekt. Główną rolę odgrywa leczenie zachowawcze i redukcja objawów. Odstawienie bifosfonia‑ nów nie ma bezpośredniego wpływu na przebieg martwicy kości szczęk, ze względu na kumulację leku w kości. Istotne jest przygotowanie pacjenta przed rozpoczęciem podawania bifosfonianów, wymagające stałej współ‑ pracy pomiędzy lekarzami onkologami, ortopedami i chirurgami szczękowo-twarzowymi. Higiena jamy ustnej i leczenie chorób współistniejących stanowi ważny element postępowania. Celem pracy jest przedstawienie trzech przypadków martwicy kości szczęk u pacjentów poddanych leczeniu bifosfonianami.

  11. “Para mulheres na ciência”: uma análise do programa da L’Oréal

    Directory of Open Access Journals (Sweden)

    Fabiani Figueiredo Caseira

    2016-01-01

    Full Text Available O presente artigo tem como objetivo investigar premiação da L’Oréal “Para Mulheres na Ciência”. Esta pesquisa se fundamenta a partir do campo teórico dos estudos feministas e de gênero, na sua vertente pós-estruturalista. Os dados de análise serão produzidos a partir da página da premiação, bem como alguns excertos presentes nos sites das parcerias ABC e UNESCO. As análises estarão ancoradas em algumas ferramentas da análise do discurso em Foucault. Nas análises tecidas buscamos algumas condições que possibilitaram a emergência dessa premiação e os discursos produzidos acerca das mulheres na ciência.

  12. Gefitinib Plus Interleukin-2 in Advanced Non-Small Cell Lung Cancer Patients Previously Treated with Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Bersanelli, Melissa, E-mail: melissa.bersanelli@alice.it; Buti, Sebastiano; Camisa, Roberta [Oncology Unit, University Hospital of Parma, Via Gramsci, 14, 43126 Parma (Italy); Brighenti, Matteo; Lazzarelli, Silvia [Oncology Unit, Azienda Istituti Ospitalieri di Cremona, Largo Priori, 1, 26100 Cremona (Italy); Mazza, Giancarlo [Radiology Division, Spedali Civili di Brescia, P.le Spedali Civili,1, 25123 Brescia (Italy); Passalacqua, Rodolfo, E-mail: melissa.bersanelli@alice.it [1Oncology Unit, University Hospital of Parma, Via Gramsci, 14, 43126 Parma (Italy)

    2014-09-30

    The activation of lymphocytes by gefitinib treatment has been described. In this phase II pilot trial, we explored the possible synergism between IL-2 and gefitinib for non-small cell lung cancer (NSCLC) treatment. From September, 2003, to November, 2006, 70 consecutive patients with advanced, progressive NSCLC, previously treated with chemotherapy, received oral gefitinib 250 mg daily. The first 39 patients received gefitinib alone (G group). The other 31 also received subcutaneous IL-2 (GIL-2 group): 1 MIU/m{sup 2} (Million International Unit/m{sup 2})twice a day on Days 1 and 2, once a day on Days 3, 4, 5 every week for four consecutive weeks with a four-week rest period. Median follow-up was 25.2 months. Grade 3–4 toxicity of gefitinib was represented by skin rash (7%), asthenia/anorexia (6%) and diarrhea (7%); patients treated with IL-2 showed grade 2–3 fever (46%), fatigue (21%) and arthralgia (13%). In the GIL-2 group and G-group, we respectively observed: an overall response rate of 16.1% (6.4% complete response) and 5.1% (only partial response); a disease control rate of 41.9% and 41%; a median time to progression of 3.5 (CI 95% = 3.2–3.8) and 4.1 (CI 95% = 2.6–5.7) months; a median overall survival of 20.1 (CI 95% = 5.1–35.1) and 6.9 (CI 95% = 4.9–8.9) months (p = 0.002); and an actuarial one-year survival rate of 54% and 30%. Skin toxicity (p < 0.001; HR = 0.29; CI 95% = 0.16–0.54) and use of IL-2 (p < 0.001; HR = 0.33; CI 95% = 0.18–0.60) were independently associated with improvement of survival. In this consecutive, non-randomized, series of advanced NSCLC patients, the use of IL-2 increased the efficacy of gefitinib.

  13. CiF-CK: An Architecture for Social NPCs in Commercial Games

    NARCIS (Netherlands)

    Guimaraes, Manuel; Santos, Pedro A.; Jhala, Arnav

    2018-01-01

    We present and describe CiF-CK — a social agent architecture that models reasoning about persistent social interactions to improve narrative engagement and play experience for human interactors. The architecture is inspired by McCoy et al’s Comme il-Faut (CiF) architecture that represented

  14. Underestimation of Severity of Previous Whiplash Injuries

    Science.gov (United States)

    Naqui, SZH; Lovell, SJ; Lovell, ME

    2008-01-01

    INTRODUCTION We noted a report that more significant symptoms may be expressed after second whiplash injuries by a suggested cumulative effect, including degeneration. We wondered if patients were underestimating the severity of their earlier injury. PATIENTS AND METHODS We studied recent medicolegal reports, to assess subjects with a second whiplash injury. They had been asked whether their earlier injury was worse, the same or lesser in severity. RESULTS From the study cohort, 101 patients (87%) felt that they had fully recovered from their first injury and 15 (13%) had not. Seventy-six subjects considered their first injury of lesser severity, 24 worse and 16 the same. Of the 24 that felt the violence of their first accident was worse, only 8 had worse symptoms, and 16 felt their symptoms were mainly the same or less than their symptoms from their second injury. Statistical analysis of the data revealed that the proportion of those claiming a difference who said the previous injury was lesser was 76% (95% CI 66–84%). The observed proportion with a lesser injury was considerably higher than the 50% anticipated. CONCLUSIONS We feel that subjects may underestimate the severity of an earlier injury and associated symptoms. Reasons for this may include secondary gain rather than any proposed cumulative effect. PMID:18201501

  15. O sistemismo de Bunge como base teórica e metodológica para pesquisa em Ciência da Informação

    Directory of Open Access Journals (Sweden)

    Luciana Mara Silva

    2016-08-01

    Full Text Available O objetivo do estudo é aprofundar aspectos epistemológicos da Ciência da Informação (CI a partir das contribuições do pensamento de Bunge. Justifica-se pela natureza interdisciplinar da CI e sua constante necessidade de interação com outras áreas de conhecimento. Trata-se de um ensaio teórico a partir da análise de conceitos da área de CI e a proposta sistemista de Bunge. O estudo é complementado com a aplicação dos fundamentos do sistemismo em pesquisas sistemistas, uma descritiva e outra explicativa, sobre repositórios institucionais de acesso aberto, exemplificando a condução de pesquisa sob a operação epistêmica fundamental do sistemismo: a redução ao sistema.

  16. Nieswoiste zapalenia jelit a płodność, przebieg ciąży, porodu i karmienie piersią

    Directory of Open Access Journals (Sweden)

    Dorota Szczeblowska

    2011-07-01

    Full Text Available Do nieswoistych zapaleń jelit zaliczamy wrzodziejące zapalenie jelita grubego i chorobę Leśniowskiego-Crohna. Ponieważ szczyt zapadalności na te choroby przypada między 15. a 35. rokiem życia, a więc dotyczy osób w okresie prokreacyjnym, rodzi się szereg pytań i wątpliwości na temat wpływu tych schorzeń oraz ich leczenia na płodność, a także przebieg ciąży, porodu i ewentualne bezpieczeństwo późniejszego karmienia piersią. W opracowaniu zostały przedstawione zasady leczenia nieswoistych zapaleń jelit u mężczyzn oraz u kobiet planujących posiadanie potomstwa, jak również kobiet będących w ciąży i karmiących. Należy podkreślić, że sam fakt rozpoznania nieswoistych chorób zapalnych jelit nie jest bezpośrednim przeciwwskazaniem do zajścia w ciążę. Ciąża nie stanowi również wskazania do przerwania leczenia tych chorób, tj. nieswoistych zapaleń jelit, gdyż zaostrzenie ich przebiegu wiąże się z większym ryzykiem dla potomstwa w porównaniu z niebezpieczeństwem wynikają- cym z wdrożenia nawet agresywnego, a skutecznego leczenia. Aktywacja tych chorób zwiększa zarówno ryzyko poronień, jak i porodów przedwczesnych oraz wewnątrzmacicznego obumarcia płodu. Nieprzerwana farmakoterapia nieswoistych zapaleń jelit środkami niemającymi działania karcynogennego ma istotny wpływ na urodzenie zdrowego dziecka. Optymalnym czasem do zajścia w ciążę w takim przypadku jest okres po trwającej przynajmniej 3 miesiące remisji choroby. W okresie planowania ciąży zaleca się suplementację kwasu foliowego.

  17. Potential protective effect of lactation against incidence of type 2 diabetes mellitus in women with previous gestational diabetes mellitus: A systematic review and meta-analysis.

    Science.gov (United States)

    Tanase-Nakao, Kanako; Arata, Naoko; Kawasaki, Maki; Yasuhi, Ichiro; Sone, Hirohito; Mori, Rintaro; Ota, Erika

    2017-05-01

    Lactation may protect women with previous gestational diabetes mellitus (GDM) from developing type 2 diabetes mellitus, but the results of existing studies are inconsistent, ranging from null to beneficial. We aimed to conduct a systematic review to gather available evidence. Databases MEDLINE, CINAHL, PubMed, and EMBASE were searched on December 15, 2015, without restriction of language or publication year. A manual search was also conducted. We included observational studies (cross-sectional, case-control, and cohort study) with information on lactation and type 2 diabetes mellitus incidence among women with previous GDM. We excluded case studies without control data. Data synthesis was conducted by random-effect meta-analysis. Fourteen reports of 9 studies were included. Overall risk of bias using RoBANS ranged from low to unclear. Longer lactation for more than 4 to 12 weeks postpartum had risk reduction of type 2 diabetes mellitus compared with shorter lactation (OR 0.77, 95% CI 0.01-55.86; OR 0.56, 95% CI 0.35-0.89; OR 0.22, 95% CI 0.13-0.36; type 2 diabetes mellitus evaluation time 5 y, respectively). Exclusive lactation for more than 6 to 9 weeks postpartum also had lower risk of type 2 diabetes mellitus compared with exclusive formula (OR 0.42, 95% CI 0.22-0.81). The findings support the evidence that longer and exclusive lactation may be beneficial for type 2 diabetes mellitus prevention in women with previous GDM. However, the evidence relies only on observational studies. Therefore, further studies are required to address the true causal effect. © 2017 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd.

  18. Contribuição das ciências cognitivas e da ciência da informação para representação da informação: proposta para utilização na construção de biblioteca virtual temática em saúde

    Directory of Open Access Journals (Sweden)

    Leandro Guedes da Fonseca

    2012-01-01

    Full Text Available Aborda aspectos das Ciências Cognitivas que podem aprimorar a representação da informação na construção de bibliotecas virtuais temáticas em saúde, visando sua utilização por distintos tipos de usuários. Mostra as vantagens das novas tecnologias de informação e comunicação, que possibilita maior dinamismo nos fluxos de informação e propicia o seu compartilhamento simultâneo. Apresenta o surgimento das Ciências Cognitivas e suas relações com a Ciência da Informação. Discorre sobre características e funcionalidades desejáveis para uma biblioteca virtual temática. Descreve a importância da contribuição da Ciência da Informação para a sociedade. Conclui ratificando a importância do caráter interdisciplinar das áreas, com vistas ao aprimoramento de produtos e serviços de informação em benefício do usuário.

  19. Posições subjetivistas e objetivistas de ciência: a hermenêutica como fundamento da pesquisa qualitativa

    Directory of Open Access Journals (Sweden)

    João Manoel Roratto

    2010-04-01

    Full Text Available Este trabalho discute aspectos relacionados à evolução recente da ciência, com ênfase no conflito entre posições objetivistas e subjetivistas, até chegar à importância da pesquisa qualitativa na construção do conhecimento científico na atualidade, com base nos variados campos de tradição e linhas de pensamento nas ciências sociais e nas formulações teóricas de Gadamer sobre hermenêutica. Nos estudos de Denzin e Lincoln, analisa-se a relevância da pesquisa qualitativa nos últimos tempos e sua forma metodológica diversificada e peculiar de representar as diferentes realidades que compõem o universo social, bem como as expectativas desse modelo de pesquisa a se afirmar como ciência. Em Gadamer, busca-se entender a construção do processo retórico e hermenêutico como método para compreender e explicar a realidade social, cujas bases ontológicas estão nas ideias originais de Platão sobre discurso e de Aristóteles sobre filosofia prática.

  20. Ciência da Informação, ciência e revolução científica:breve histórico e reflexõesCiencia de la Información, ciencia y revolución científica: breve histórico y reflexiones

    Directory of Open Access Journals (Sweden)

    Ednéa Zandonadi Brambila

    2006-02-01

    Full Text Available O artigo traz uma breve introdução histórica da construção do saber e do nascimento da ciência, percorrendo os caminhos desde os primórdios da humanidade quando o homem se descobriu até os dias atuais, com a evolução constante da ciência, seja investigando, testando, experimentando e até refutando teorias. Aborda questões da ciência e da revolução científica, do pensamento científico moderno, da construção do saber racional a partir da observação da realidade (empirismo e da experimentação para então chegar ao surgimento da Ciência da Informação, cujo nascimento para alguns autores tem origem no Séc. XIX com Paul Otlet e Henri La Fontaine, pioneiros da Documentação. Discute conceitos numa perspectiva histórica, concluindo ser a Ciência da Informação uma nova disciplina, uma nova forma do conhecimento que se inter-relaciona com outras disciplinas, tendo sofrido mudanças consideráveis desde a sua concepção, repensando seu objeto de estudo e reforçando a idéia de que a informação é o resultado de um processo cognitivo humano.

  1. Powrócić do początku, czyli jak kultura maskuje swoją zmienność?

    Directory of Open Access Journals (Sweden)

    Jan Kajfosz

    2015-12-01

    Full Text Available Return to the beginnings, or how culture masks its changes?  The aim of this essay is to describe cognitive mechanisms on which imagined intersubjectively important continuities and discontinuities in culture are based, and thus allow creating and transforming collective identities. The author uses tools of phenomenology and semiotics to provide answers to a few questions concerning cognitive mechanisms of memory and symbolic violence as well as the ways in which culture can change and adapt to current socio-political needs. These issues pertain also to nation and national identities.   Powrócić do początku, czyli jak kultura maskuje swoją zmienność?  Celem przyczynku jest próba odpowiedzi na pytanie, na jakich kognitywnych mechanizmach opiera się konstruowanie wyobrażonych, intersubiektywnie ważnych ciągłości i nieciągłości w kulturze, będących podstawą tworzenia i przetwarzania tożsamości zbiorowych. Posługując się narzędziami fenomenologii i semiotyki, autor chce dostarczyć odpowiedzi na następujące pytania: Na podstawie jakich kognitywnych mechanizmów pamięć – wraz z jej społecznymi ramami – może się dostosowywać do aktualnie ważnych społeczno-politycznych potrzeb? Na jakich kognitywnych mechanizmach opiera się przemoc symboliczna? W jaki sposób kultura potrafi eliminować pamięć o własnych przemianach? – Propozycje zawierające się w artykule wskazują na retoryczny (perswazyjny, legitymizacyjny i światotwórczy – czyli pragmatyczny – wymiar konotacji, a zwłaszcza „zgęszczeń konotacji” nazywanych przez R. Barthesa mitem. Podstawową funkcję eksplanacyjną w odniesieniu do pytań o kognitywne mechanizmy społecznego konstruowania przeszłości (inaczej: „początku” oprócz konotacji mają tu takie kategorie, jak percepcja magiczna i myślenie magiczne.

  2. Trudności diagnostyczne i terapeutyczne w przypadku ziarniniaka grzybiastego rozpoznanego wstępnie jako actinic reticuloid

    Directory of Open Access Journals (Sweden)

    Małgorzata Sokołowska-Wojdyło

    2010-07-01

    Full Text Available Wprowadzenie: Ziarniniak grzybiasty (mycosis fungoides – MF to chłoniako niskiej złośliwości, wywodzący się z obwodowych komórek T,pierwotnie zajmujący skórę. Cel pracy: Przedstawienie trudności diagnostycznych i terapeutycznychw MF. Opis przypadku: Przedstawiono przypadek dotyczący 72-letniejpacjentki z MF, objętej opieką przez Klinikę od października 2007 dowrześnia 2009 roku. Zmiany skórne miały cechy melanoerytrodermii,a obraz histopatologiczny wycinków ze zmian nie upoważniał do rozpoznaniarozrostu złośliwego. Początkowo rozpoznawano osutkępolekową oraz actinic reticuloid. Rozpoznanie MF ustalono dopiero po19 miesiącach obserwacji. Na skórze chorej wystąpiły zmiany rumieniowo-naciekowe, które w badaniu histopatologicznym miały cechyMF. Dwa miesiące później chora zmarła, mimo leczenia cytostatycznegoi naświetlań szybkimi elektronami. Wnioski: Przedstawiony przypadek potwierdza trudności diagnostycznewynikające z podobieństwa wczesnych okresów chłoniaka dodermatoz o podłożu zapalnym. Wyjątkowo niepomyślny przebieg choroby– pacjentka zmarła po 2 latach od momentu ustalenia rozpoznania– uzmysławia także ograniczenia możliwości terapeutycznych,szczególnie w zaawansowanych stadiach MF.

  3. Bioética clínica: ciência e humanidade = Clinical bioethics: science and humanity

    Directory of Open Access Journals (Sweden)

    Batista, Cristiano Corrêa

    2005-01-01

    Full Text Available Objetivo: A medicina pré-moderna tinha por enfoque a harmonia entre o universo e a natureza e tudo era aparentemente possível para os médicos aptos a interpretarem sinais e sintomas. A partir da invenção do estetoscópio inicia-se o processo de investigação do interior dos corpos vivos. Ao longo do tempo, a medicina foi sendo impregnada com a tecnologia e, nos dias atuais, a chamada tecnociência se faz onipresente deixando em segundo plano, ou até mesmo ausente, a interação médico-paciente. Urge a criação de uma nova indústria intelectual com a capacidade de criticar essa nova forma de praticar a medicina embasada principalmente na tecnologia. O objetivo do presente artigo é fazer uma reflexão, por meio da bioética clínica, dessa nova forma de praticar a medicina na tentativa de resgatar o lado humano da ciência médica. Método: Foi realizada uma consulta na base de dados da Medline e LILACS nos últimos dez anos e uma revisão da literatura nacional em torno do tema medicina, bioética, ciência e humanidade. Resultados e conclusão: Nossa conclusão é de a medicina não ser apenas uma ciência, mas também uma arte. Ela exige, em situações particulares, elaborar julgamentos de valor. A Bioética Clínica, surge para guiar caminhos combinando o conhecimento técnico-científico das ciências biomédicas com o conhecimento filosófico. Por meio da Bioética Clínica é possí- vel resgatar os aspectos humanos da arte da medicina

  4. Random comparison study of the clinical response to 153Sm-EDTMP 1.0 mCi/kg and 1.5 mCi/kg

    International Nuclear Information System (INIS)

    Pan, Z.; Zhu, S.

    2001-01-01

    Sixty-seven patient with painful bone metastases were randomized to two groups. Group 1 (n=34) received 1.0 mCi/kg of 153 Sm-EDTMP and group II (n=33) received 1.5 mCi/kg. All of them met inclusion criteria and there was no significantly difference between the basic conditions of two groups. After receiving 153 Sm-EDTMP intravenously, all patients were kept in close follow-up weekly with blood counting, physician visiting and collecting patient's self-filling-in diary including pain score, Karnofsky performance scale and analgesic consumption. The follow-up duration was six weeks. The final overall condition assessed by physician were graded into no change (including worse), slight relief, significant relief and complete relief. Only significant relief and complete relief were considered as effectiveness for pain relief. Haematological toxicity grade was evaluated based on the nadir of WBC ad PLT counts. The results indicated that the higher dosage group had a higher effectiveness rate (75.76%) compared to the lower dosage group (67.65%), but without statistic significance (x 2 =0.5365, 0.25 153 Sm-EDTMP could be used for those patients with better haematological function and 1.0 mCi/kg used for those patients with poorer haematological function. (author)

  5. O que é pesquisar - entre Deleuze-Guattari e o candomblé, pensando mito, ciência, arte e culturas de resistência

    Directory of Open Access Journals (Sweden)

    Gauthier Jacques

    1999-01-01

    Full Text Available A ciência atual é uma ciência do evento e do acontecimento. Explorando, após Deleuze, a diferença entre evento e acontecimento na filosofia estóica, o autor caracteriza vários modos de "fazer ciência": a dupla captura, referida, numa visão transcultural, à divindade Ogum do candomblé; a maturação escura, referida à divindade Ossãe etc. Daí são discutidos, com base em Spinoza, a questão do local e do universal na construção do conhecimento, e com base em Michel Serres, o problema da articulação entre mito e ciência. A pesquisa de Graziela Rodrigues, "Bailarino-pesquisador-intérprete: Processo de formação", é tomada como exemplo de abordagem inovadora, transcultural e sociopoética. Uma pergunta conclui este artigo: será que a descolonização dos espíritos (e dos corpos passa pela criação de uma episteme transcultural?

  6. Wybrane aspekty dotyczące przychodów i kosztóww przedsiębiorstwie postawionymw stan upadłości likwidacyjnej

    Directory of Open Access Journals (Sweden)

    Janusz Czerny

    2009-06-01

    Full Text Available Celem postępowania upadłościowego, które prowadzi do likwidacji przedsiębiorstwa, jest osiągnięcie przychodów ze zbycia jego majątku, co pozwoliłyby na pokrycie kosztów postępowania i zaspokojenia wierzycieli. W upadłości likwidacyjnej przedsiębiorstw mamy do czynienia z dwoma strumieniami przychodów: z przychodami dotyczącymi zbycia przedsiębiorstwa lub jego składników majątku oraz z przychodami związanymi z ewentualnym kontynuowaniem działalności. Przychody ze sprzedaży przedsiębiorstwa powinny być prognozowane głównie na podstawie informacji płynących z systemu rachunkowości, co stanowi tzw. statyczny aspekt upadłości i jest związane z wyceną masy upadłości. Aspekt dynamiczny zaś wiąże się z zakresem i czasem kontynuowanej działalności, o czym decyduje syndyk. Decyzję o zakresie i czasie kontynuowania działalności w przedsiębiorstwie postawionym w stan upadłości likwidacyjnej powinien podjąć syndyk, opierając się na danych generowanych przez system rachunkowości, przy wykorzystaniu narzędzi analizy finansowej. Bardzo istotnym staje się zatem właściwe zarządzanie kosztami procesu upadłości, polegające na ich minimalizacji, co wymaga opracowania przez syndyka budżetu wydatków postępowania upadłościowego oraz przychodów i kosztów kontynuowanej działalności, a następnie szczegółowej kontroli ich wykonania.

  7. Life and death of an influential passenger: Wolbachia and the evolution of CI-modifiers by their hosts.

    Directory of Open Access Journals (Sweden)

    Arnulf Koehncke

    Full Text Available Wolbachia are intracellular bacteria widely distributed among arthropods and nematodes. In many insect species these bacteria induce a cytoplasmic incompatibility (CI between sperm of infected males and eggs of uninfected females. From an evolutionary point of view, CI is puzzling: In order to induce this modification-rescue system, Wolbachia affect sperm of infected males even though Wolbachia are only transmitted maternally. Phylogenetic studies of Wolbachia and hosts show that the bacteria rarely cospeciate with their hosts, indicating that infections are lost in host species. However, the mechanisms leading to Wolbachia loss are not well understood.Using a population genetic model, we investigate the spread of host mutants that enhance or repress Wolbachia action by affecting either bacterial transmission or the level of CI. We show that host mutants that decrease CI-levels in males (e.g. by reducing Wolbachia-density during spermatogenesis spread, even at cost to mutant males. Increase of these mutants can lead to loss of Wolbachia infections, either as a direct consequence of their increase or in a step-wise manner, and we derive analytically a threshold penetrance above which a mutation's spread leads to extinction of Wolbachia. Selection on host modifiers is sexually antagonistic in that, conversely, host mutants that enhance Wolbachia in females are favoured whereas suppressors are not.Our results indicate that Wolbachia is likely to be lost from host populations on long evolutionary time scales due to reduction of CI levels in males. This can occur either by evolution of single host modifiers with large effects or through accumulation of several modifier alleles with small effects on Wolbachia action, even at cost to mutant males and even if infected hosts do not incur fecundity costs. This possibility is consistent with recent findings and may help to explain the apparent short evolutionary persistence times of Wolbachia in many host

  8. O imprescindível aporte das ciências sociais para o planejamento e a compreensão do turismo

    Directory of Open Access Journals (Sweden)

    Margarita Barretto

    2003-10-01

    Full Text Available O artigo busca legitimar a necessidade do concurso das ciências sociais no planejamento do turismo, apresentando uma pequena revisão bibliográfica da história da produção das ciências sociais aplicadas ao estudo do turismo e levantando questões cruciais do planejamento de turismo que poderiam ser melhor resolvidas com a contribuição das pesquisas socioantropológicas.The aim of this article is to discuss that tourism planning needs the support of social sciences, presenting a quick review of social sciences studies on tourism and raising crucial problems in tourism planning that could be lessened with the help of anthropological and sociological research.

  9. Układ pojęć konstytuujących teorię rachunkowości w kontekście nauk ekonomicznych

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    Mieczysław Dobija

    2016-09-01

    Full Text Available Każda teoria wyjaśniająca zjawiska rzeczywistego świata ma za podstawę pojęcia pierwotne i fundamen-talne zasady oraz definicje podstawowych koncepcji, które następnie są materią do formułowania stwier-dzeń orzekających, przy zastosowaniu logiki i postępowania naukowego. Powstaje zatem pytanie, czy ten podstawowy zbiór pojęć dla wiedzy zwanej rachunkowością pokrywa się z odpowiednikiem z zakresu ekonomii. Analiza tej kwestii jest bezsprzecznie zasadna, ponieważ już kategoria kapitału ma w rachun-kowości nierzadko inne znaczenie niż w ekonomii czy w naukach o zarządzaniu. Rozważania prowadzą do wniosku, że podstawowy układ pojęć konstytuujący teorię rachunkowości jest jednoznacznie określo-ny, natomiast ten stan niekoniecznie występuje w innych naukach ekonomicznych. Różnią się też kon-cepcje i podejścia do kategorii wartości, co powoduje, że dyscypliny nauk ekonomicznych są w małym stopniu komplementarne.

  10. Concepções de ciência de um grupo de licenciandas em Pedagogia e suas relações com o processo formativo

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Santos Souza

    2015-12-01

    Full Text Available ResumoEste artigo apresenta uma análise das concepções de ciência de um grupo de licenciandas de um curso de Licenciatura em Pedagogia e suas relações com as concepções apresentadas em documentos do curso e pela docente da disciplina Conteúdos e Metodologia do Ensino Fundamental de Ciências. Partimos das seguintes questões: uais as concepções de ciência demonstradas por concluintes do curso de Licenciatura em Pedagogia? Como essas concepções podem estar relacionadas ao processo formativo das licenciandas? O estudo ampara-se teoricamente em Habermas, que considera três tradições das ciências: empírico-analítica, histórico-hermenêutica e crítica. Os dados foram constituídos por meio de documentos e entrevistas semiestruturadas. Os resultados demonstraram que a abordagem crítica que fundamenta o curso não foi materializada na construção ou revisão das concepções de ciência das discentes durante seu processo formativo, prevalecendo entre as mesmas, sobretudo, concepções de cunho positivista.

  11. Do fabryki! Lenin Negriego i cięcie podmiotowe (1968-1973

    Directory of Open Access Journals (Sweden)

    Michael Hardt

    2016-06-01

    Full Text Available Tekst stanowi fragment doktoratu Michaela Hardta Sztuka organizacji: źródła ontologii politycznej u Gilles'a Deleuze'a i Antonio Negriego. Autor analizuje w nim dialog, jaki Antonio Negri podejmuje z pismami Włodzimierza Lenina w okresie intensywnych walk społecznych i przekształceń składu klasowego we Włoszech w latach 1968-1973. Doszukując się w tym spotkaniu kluczowego zwrotu teoretycznego w myśli włoskiego marksisty, Hardt przekonuje, że to właśnie w tekstach rosyjskiego rewolucjonisty Negri odnalazł narzędzia pozwalające mu wyjść poza ograniczenia krytycznego marksizmu, uznającego klasę robotniczą przede wszystkim za obiekt wyzysku, przez uczynienie kwestii jej podmiotowości centralnym zagadnieniem i punktem wyjścia teorii.

  12. Ceux-ci ne sont pas : [luuletused] / Kalju Kruusa

    Index Scriptorium Estoniae

    Kruusa, Kalju, pseud., 1973-

    2003-01-01

    Sisu: Ceux-ci ne sont pas ; Köögivahet ; "Taara..." ; "Pakane pistab pisikesi ..." ; "Meri on kaet mattklaasiga ; Pydemise päivil ; "Toas muusika mängib ..." ; "Jäin juustu imetlema ; "Mu elu on mustikas ..." ; Hingepidetus ; ŁNo me gusta la cocina

  13. Previous hepatitis a virus infection is related to slower psychomotor speed in elderly adults.

    Science.gov (United States)

    Hsieh, Cheng-Fang; Liu, Ching-Kuan; Fang, Tzu-Jung; Yu, Yau-Hua; Lai, Chiou-Lian; Kuo, Hsu-Ko

    2009-10-01

    Patients with chronic viral hepatitis are at a higher risk for cognitive dysfunction. Little is known about the association between hepatitis A virus (HAV) infection and cognitive function. From the National Health and Nutrition Examination Survey, 1999-2002, we selected study participants (> or =60 years, n = 1,529) without hepatitis B, C, or D virus infection; without previous hepatitis A vaccination; and without abnormal liver function. HAV-seropositive participants represented people with previous HAV infection. Psychomotor speed and executive functioning domain of cognitive function were measured by the Digit Symbol Substitution Test (DSST). HAV-seropositive participants had lower DSST scores than HAV-seronegative participants (weighted mean, 44.4 vs 53.9, p a multivariable model, the weighted adjusted beta coefficient of DSST score was -2.48 (95% CI -2.49 to -2.46, p < .001) for the HAV-seropositive participants. HAV seropositivity is associated with slower psychomotor speed among the U.S. community-dwelling elders.

  14. Branding Grenlandii formą ekspresji tożsamości narodowej?

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    Dominika Bartnik-Światek

    2016-01-01

    Full Text Available Branding Greenland as a form of expression of national identity? In the times of globalisation there is a tendency for countries to differentiate from others. More and more governments decide to launch professional nation branding campaigns in order to communicate to a broad public what a particular country has to offer as well as what values and images it wants to be associated with. Greenland is an example of a country that after a long period of colonisation and establishing self-government, in 2009 began to redefine its identity and reveal it to the world. A branding campaign has been implemented to communicate a newly defined image of Greenland. This campaign has been carried out using mainly social media and the tools that the Internet has to offer. The aim of this paper is to explore the concept of nation branding and to define the relation between nation branding and national identity. The purpose is also to analyse what images of Greenland as a brand are presented by “Pioneering nation” campaign.   Branding Grenlandii formą ekspresji tożsamości narodowej? W czasach globalizacji poszczególne państwa starają się wyróżnić na tle innych państw. Coraz więcej rządów decyduje się na przeprowadzenie profesjonalnych kampanii brandingowych, po to by podkreślić swoją wyjątkowość oraz to, że mają dużo do zaoferowania. Grenlandia to przykład państwa, które po długim okresie skolonizowania i po uzyskaniu autonomii w 2009 roku, zaczęło na nowo definiować swoją tożsamość i komunikować ją światu. W tym celu wdrożona została kampania, która wykorzystywała głównie media społecznościowe oraz inne narzędzia, które zapewnia internet. Celem niniejszego artykułu jest zbadanie zależności między brandingiem narodowym a tożsamością narodową, jak też analiza obrazu Grenlandii jako marki konstruowanej w kampanii „Pioneering nation”.

  15. The Affordable Care Act, Insurance Coverage, and Health Care Utilization of Previously Incarcerated Young Men: 2008-2015.

    Science.gov (United States)

    Winkelman, Tyler N A; Choi, HwaJung; Davis, Matthew M

    2017-05-01

    To estimate health insurance and health care utilization patterns among previously incarcerated men following implementation of the Affordable Care Act's (ACA's) Medicaid expansion and Marketplace plans in 2014. We performed serial cross-sectional analyses using data from the National Survey of Family Growth between 2008 and 2015. Our sample included men aged 18 to 44 years with (n = 3476) and without (n = 8702) a history of incarceration. Uninsurance declined significantly among previously incarcerated men after ACA implementation (-5.9 percentage points; 95% confidence interval [CI] = -11.5, -0.4), primarily because of an increase in private insurance (6.8 percentage points; 95% CI = 0.1, 13.3). Previously incarcerated men accounted for a large proportion of the remaining uninsured (38.6%) in 2014 to 2015. Following ACA implementation, previously incarcerated men continued to be significantly less likely to report a regular source of primary care and more likely to report emergency department use than were never-incarcerated peers. Health insurance coverage improved among previously incarcerated men following ACA implementation. However, these men account for a substantial proportion of the remaining uninsured. Previously incarcerated men continue to lack primary care and frequently utilize acute care services.

  16. Edukacja żywieniowa rodziny w przypadku występowania otyłości

    Directory of Open Access Journals (Sweden)

    Magdalena Pieszko

    2013-12-01

    Full Text Available Edukacja żywieniowa stanowi ważny element terapii osób z nadwagą i otyłością, będąc niejednokrotnie dopełnie‑ niem dla diety redukcyjnej czy farmakoterapii. Prawidłowo dobrana i realizowana metoda szkolenia powinna speł‑ niać funkcję czynnika mobilizującego i wzmacniającego, dzięki któremu pacjent będzie chętniej modyfikował swój styl życia. Głównym celem edukacji dotyczącej diety jest przekazanie i utrwalenie właściwych postaw żywieniowych, przy czym forma przekazu wiedzy na temat odżywiania skierowana do dzieci nie może być taka sama jak przezna‑ czona dla ich rodziców/opiekunów. Związane jest to z różnicami w rozumieniu i przyswajaniu informacji pomiędzy osobami dorosłymi i dziećmi. Mimo to trzeba pamiętać, że rodzina jest społecznością, której członkowie są ze sobą bardzo związani i mają na siebie duży wpływ – nie można zatem pominąć edukacji, która będzie zachęcała całą rodzinę do wspólnych działań. Zmiana nawyków żywieniowych musi dotyczyć wszystkich członków rodziny, gdyż to rodzice poprzez swoje poglądy, preferencje i zachowania kształtują poglądy, preferencje i zachowania dzieci. Również osoba szczupła powinna dostosować się do nowych zasad dla dobra swoich bliskich. Wzajemna moty‑ wacja może być kluczem do sukcesu. Zmiana stylu życia wiąże się też ze zwiększeniem aktywności fizycznej, która jest nieodzownym elementem terapii pacjentów otyłych. Wzrost aktywności ruchowej może skutecznie skrócić czas leczenia oraz przyczynić się do jego lepszych efektów.

  17. Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1

    DEFF Research Database (Denmark)

    Rasmussen, Kim Krighaar; Frandsen, Kristian E. H.; Erba, Elisabetta Boeri

    2016-01-01

    The CI repressor from the temperate bacteriophage TP901-1 consists of two folded domains, an N-terminal helix-turn-helix DNA-binding domain (NTD) and a C-terminal oligomerization domain (CTD), which we here suggest to be further divided into CTD1 and CTD2. Full-length CI is a hexameric protein......, whereas a truncated version, CIΔ58, forms dimers. We identify the dimerization region of CIΔ58 as CTD1 and determine its secondary structure to be helical both within the context of CIΔ58 and in isolation. To our knowledge this is the first time that a helical dimerization domain has been found in a phage...... repressor. We also precisely determine the length of the flexible linker connecting the NTD to the CTD. Using electrophoretic mobility shift assays and native mass spectrometry, we show that CIΔ58 interacts with the O-L operator site as one dimer bound to both half-sites, and with much higher affinity than...

  18. FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia.

    Science.gov (United States)

    de Claro, R Angelo; McGinn, Karen M; Verdun, Nicole; Lee, Shwu-Luan; Chiu, Haw-Jyh; Saber, Haleh; Brower, Margaret E; Chang, C J George; Pfuma, Elimika; Habtemariam, Bahru; Bullock, Julie; Wang, Yun; Nie, Lei; Chen, Xiao-Hong; Lu, Donghao Robert; Al-Hakim, Ali; Kane, Robert C; Kaminskas, Edvardas; Justice, Robert; Farrell, Ann T; Pazdur, Richard

    2015-08-15

    On November 13, 2013, the FDA granted accelerated approval to ibrutinib (IMBRUVICA capsules; Pharmacyclics, Inc.) for the treatment of patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. On February 12, 2014, the FDA granted accelerated approval for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. Ibrutinib is a first-in-class Bruton's tyrosine kinase (BTK) inhibitor that received all four expedited programs of the FDA: Fast-Track designation, Breakthrough Therapy designation, Priority Review, and Accelerated Approval. Both approvals were based on overall response rate (ORR) and duration of response (DOR) in single-arm clinical trials in patients with prior treatment. In MCL (N = 111), the complete and partial response rates were 17.1% and 48.6%, respectively, for an ORR of 65.8% [95% confidence interval (CI), 56.2%-74.5%]. The median DOR was 17.5 months (95% CI, 15.8-not reached). In CLL (N = 48), the ORR was 58.3% (95% CI, 43.2%-72.4%), and the DOR ranged from 5.6 to 24.2 months. The most common adverse reactions (≥ 30% in either trial) were thrombocytopenia, diarrhea, neutropenia, bruising, upper respiratory tract infection, anemia, fatigue, musculoskeletal pain, peripheral edema, and nausea. ©2015 American Association for Cancer Research.

  19. Aprendizagem baseada em problemas no ensino de ciências: Mudando atitudes de alunos e professores

    Directory of Open Access Journals (Sweden)

    João Manoel da Silva Malheiro

    2008-06-01

    Full Text Available O aprendizado baseado em problemas (APB é apontado como ferramenta importante para ensinar os alunos a aprender com autonomia. O objetivo deste trabalho é comparar a forma habitual de ensinar Ciências e Biologia no Ensino Médio da Escola Pública com a metodologia da Aprendizagem Baseada em Problemas (ABP. Para tanto, dois Cursos de Férias frequentados por alunos e professores do ensino médio foram baseados na ABP e dedicados à redescoberta da anatomia do corpo de animais com estilos de vida contrastantes. Foram feitas análises qualitativas e quantitativas a partir de questionários aplicados antes e depois dos cursos a alunos e professores. Os resultados apontaram para maior motivação dos alunos e professores em ciências e biologia após os cursos de férias e para a possibilidade da utilização imediata da metodologia no ensino médio na escola pública a despeito das restrições atuais de infra-estrutura.

  20. A modified CAS-CI approach for an efficient calculation of magnetic exchange coupling constants

    Science.gov (United States)

    Fink, Karin; Staemmler, Volker

    2013-09-01

    A modification of the conventional wavefunction-based CAS-CI method for the calculation of magnetic exchange coupling constants J in small molecules and transition metal complexes is presented. In general, CAS-CI approaches yield much too small values for J since the energies of the important charge transfer configurations are calculated with the ground state orbitals and are therefore much too high. In the present approach we improve these energies by accounting for the relaxation of the orbitals in the charge transfer configurations. The necessary relaxation energies R can be obtained in separate calculations using mononuclear or binuclear model systems. The method is applied to a few examples, small molecules, binuclear transition metal complexes, and bulk NiO. It allows to obtaining fairly reliable estimates for J at costs that are not higher than those of conventional CAS-CI calculations. Therefore, extended and very time-consuming perturbation theory (PT2), configuration interaction (CI), or coupled cluster (CC) schemes on top of the CAS-CI calculation can be avoided and the modified CAS-CI (MCAS-CI) approach can be applied to rather large systems.

  1. Desenvolvimento de recursos didáticos para o ensino de geociências para a Banca das Ciências e Experimentoteca da EACH/USP

    Directory of Open Access Journals (Sweden)

    Caroline Bertocco Garcia

    2015-06-01

    Full Text Available O presente trabalho abrange a importância da divulgação e popularização da Ciência com o uso de modelos didáticos que expressem os conteúdos de Geociências. A divulgação e popularização da Ciência tem como cenário a Banca da Ciência, um projeto ligado ao Laboratório de Desenvolvimento de Recursos Didáticos em Ciência da Natu­reza, LABDID da Escola de Artes, Ciências e Humanidades, EACH-USP. Foram utilizados materiais simples, como papel cartonado de caixa descartáveis, canudos para refrigerante, cola quente, copos de iogurte descartáveis etc. e atividades apresentadas em publicações científicas da área de ensino de Geociências e do site Geoideias, para compor o acervo da Banca da Ciência, assim como para ampliar o tema Geologia no acervo da Experimentoteca do LABDID. A acessibilidade dos materiais para a construção dos modelos foi vista como um meio para a popularização das Geociências, na qual a escolha de materiais reciclados e de baixo custo permitisse a reprodução e adaptação dos modelos.

  2. Ocena możliwości implementacji standardów IPSAS do systemu rachunkowości podmiotów sektora publicznego w Polsce

    Directory of Open Access Journals (Sweden)

    Aleksandra Szewieczek

    2017-09-01

    Full Text Available Ocena możliwości implementacji standardów IPSAS do systemu rachunkowości podmiotów sektora publicznego w Polsce In recent years, there has been a noticeable increase in activity in the field of standardization of public sector accounting, which has an international scope and takes the form of the International Public Sector Accounting Standards (IPSAS. It has been planned that the EU Member States, and consequently Poland, will implement obligatory uniform accounting standards in the public sector – EPSAS – which are to be largely based on the content of IPSAS. The purpose of this paper is to assess the possibilities and factors of IPSAS implementation in the accounting system of public finance sector entities in Poland in relation to the currently applicable accounting regulations and the intelligibility criterion for potential users. The assessment was carried out based on a study of the foreign and domestic literature and existing legislation, while for the conclusions, the deductive and synthetic methods were used. The paper demonstrates that despite the relatively long period of operation of IPSAS, their level of implementation into the accounting system of public sector entities in Poland is negligible. The same applies to the works on the European standards, EPSAS, which have been significantly delayed in relation to the original assumptions. Knowledge of international standards is weak, and consequently their dissemination too. In spite of IPSAS implementation problems, there are still a number of reasons for their use. One of the arguments in favor of introducing uniform standards on the European market is the fact that the common market is in operation, and another one is the strong embedding of the need to consolidate the public sector’s international financial data at the central level of the Community. The conducted research confirmed the possibility of implementing IPSAS into Polish public sector entities’ accounting

  3. A Provisoriedade do Conhecimento Científico: Uma Reflexão sobre a Filosofia da Ciência de Karl Popper

    Directory of Open Access Journals (Sweden)

    Fátima Siqueira Caropreso

    2015-12-01

    Full Text Available A concepção de ciência de Karl Popper nos mostra que esta, embora indubitavelmente nos forneça um conhecimento muito mais seguro do que aquele do senso comum, jamais poderá alcançar um conhecimento verdadeiro, definitivo. A aspiração de verdade da ciência consiste em uma impossibilidade lógica e empírica, portanto, o conhecimento científico deve ser conhecimento falsificável e não falsificado, que se desenvolve a partir de um processo de eliminação de erros. O objetivo deste artigo é apresentar a concepção de ciência de Popper, o que parece se justificar por nos lembrar da provisoriedade das teorias científicas, em uma época em que há uma confiança muitas vezes ingênua nos dados científicos, principalmente nos meios não acadêmicos.

  4. Fluidez tectónica. As bio-tecno-ciências, a bio-arte e a paisagem cognitiva do presente

    Directory of Open Access Journals (Sweden)

    Luís Quintais

    2012-10-01

    Full Text Available O presente ensaio constitui um comentário crítico à tese de Paul Virilio de que certo tipo de práticas na fronteira entre a arte e a tecno-ciência, práticas a que se convencionou chamar “bio-arte”, epitomizam o radicalismo expressionista e niilista do presente. A investigação aqui iniciada revela, através de um olhar sobre as práticas artísticas de Eduardo Kac, que estas, longe de apelarem a tal radicalismo, só se tornam operativas e significativas numa atmosfera de compromisso ético e político que é tomada como inescapável dada a relevância que assumem as bio-tecno-ciências no mundo contemporâneo.

  5. Obstetric Outcomes of Mothers Previously Exposed to Sexual Violence.

    Science.gov (United States)

    Gisladottir, Agnes; Luque-Fernandez, Miguel Angel; Harlow, Bernard L; Gudmundsdottir, Berglind; Jonsdottir, Eyrun; Bjarnadottir, Ragnheidur I; Hauksdottir, Arna; Aspelund, Thor; Cnattingius, Sven; Valdimarsdottir, Unnur A

    2016-01-01

    There is a scarcity of data on the association of sexual violence and women's subsequent obstetric outcomes. Our aim was to investigate whether women exposed to sexual violence as teenagers (12-19 years of age) or adults present with different obstetric outcomes than women with no record of such violence. We linked detailed prospectively collected information on women attending a Rape Trauma Service (RTS) to the Icelandic Medical Birth Registry (IBR). Women who attended the RTS in 1993-2010 and delivered (on average 5.8 years later) at least one singleton infant in Iceland through 2012 formed our exposed cohort (n = 1068). For each exposed woman's delivery, nine deliveries by women with no RTS attendance were randomly selected from the IBR (n = 9126) matched on age, parity, and year and season of delivery. Information on smoking and Body mass index (BMI) was available for a sub-sample (n = 792 exposed and n = 1416 non-exposed women). Poisson regression models were used to estimate Relative Risks (RR) with 95% confidence intervals (CI). Compared with non-exposed women, exposed women presented with increased risks of maternal distress during labor and delivery (RR 1.68, 95% CI 1.01-2.79), prolonged first stage of labor (RR 1.40, 95% CI 1.03-1.88), antepartum bleeding (RR 1.95, 95% CI 1.22-3.07) and emergency instrumental delivery (RR 1.16, 95% CI 1.00-1.34). Slightly higher risks were seen for women assaulted as teenagers. Overall, we did not observe differences between the groups regarding the risk of elective cesarean section (RR 0.86, 95% CI 0.61-1.21), except for a reduced risk among those assaulted as teenagers (RR 0.56, 95% CI 0.34-0.93). Adjusting for maternal smoking and BMI in a sub-sample did not substantially affect point estimates. Our prospective data suggest that women with a history of sexual assault, particularly as teenagers, are at increased risks of some adverse obstetric outcomes.

  6. Determinants Of European Banks' Capital Adequacy / Determinanty Adekwatności Kapitałowej Banków Europejskich

    Directory of Open Access Journals (Sweden)

    Klepczarek Emilia

    2015-12-01

    Full Text Available W artykule przedstawiono analizę czynników wpływających na poziom wskaźnika CET 1 ratio, będącego miarą relacji pomiędzy kapitałem podstawowym banku a aktywami ważonymi ryzykiem. Badaniu poddano próbę losowo wybraną z grupy banków uczestniczących w tzw. stress-testach przeprowadzonych przez władze Europejskiego Banku Centralnego. EBC przeprowadził testy warunków skrajnych oceniając m.in. poziom współczynnika CET1 obliczanego według regulacji wynikających z III Reżimu Bazylejskiego. Wyniki potwierdzają hipotezę o wpływie wielkości banku i wskaźników ryzyka (aktywa ważone ryzykiem do aktywów ogółem; udział pożyczek w aktywach ogółem na poziom adekwatności kapitałowej. Potwierdzono również silny wpływ konkurencji, a także ujemną korelację między wskaźnikiem CET1 i udziałem depozytów w zobowiązaniach kapitałowych, którą można uzasadnić istnieniem systemu gwarantowania depozytów. W końcowej części artykułu przedstawiono możliwe słabości przeprowadzonych badań, wynikające z nich ograniczenia wnioskowania oraz koncepcje ewentualnych dalszych analiz przedmiotowego obszaru tematycznego.

  7. Identification and characterization of novel long-term metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GC-CI-MS/MS.

    Science.gov (United States)

    Polet, Michael; Van Gansbeke, Wim; Geldof, Lore; Deventer, Koen; Van Eenoo, Peter

    2017-11-01

    The search for metabolites with longer detection times remains an important task in, for example, toxicology and doping control. The impact of these long-term metabolites is highlighted by the high number of positive cases after reanalysis of samples that were stored for several years, e.g. samples of previous Olympic Games. A substantial number of previously alleged negative samples have now been declared positive due to the detection of various long-term steroid metabolites the existence of which was unknown during the Olympic Games of 2008 and 2012. In this work, the metabolism of oxymesterone and mesterolone, two anabolic androgenic steroids (AAS), was investigated by application of a selected reaction monitoring gas chromatography-chemical ionization-triple quadrupole mass spectrometry (GC-CI-MS/MS) protocol for metabolite detection and identification. Correlations between AAS structure and GC-CI-MS/MS fragmentation behaviour enabled the search for previously unknown but expected AAS metabolites by selection of theoretical transitions for expected metabolites. Use of different hydrolysis protocols allowed for evaluation of the detection window of both phase I and phase II metabolites. For oxymesterone, a new metabolite, 18-nor-17β-hydroxymethyl-17α-methyl-4-hydroxy-androst-4,13-diene-3-one, was identified. It was detectable up to 46 days by using GC-CI-MS/MS, whereas with a traditional screening (detection of metabolite 17-epioxymesterone with electron ionization GC-MS/MS) oxymesterone administration was only detectable for 3.5 days. A new metabolite was also found for mesterolone. It was identified as 1α-methyl-5α-androstan-3,6,16-triol-17-one and its sulfate form after hydrolysis with Helix pomatia resulted in a prolonged detection time (up to 15 days) for mesterolone abuse. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Directional sensitivity of differential pressure sensors of gas velocity used in manual gravimetric measurements of dust emissions from stationary sources / Czułość kierunkowa różnicowo-ciśnieniowych czujników prędkości gazu stosowanych w manualnych pomiarach grawimetrycznych emisji zanieczyszczeń pyłowych ze źródeł stacjonarnych

    Directory of Open Access Journals (Sweden)

    Szulikowski Jerzy

    2015-09-01

    Full Text Available Na potrzeby określania emisji zanieczyszczeń pyłowych do atmosfery z przemysłowych instalacji technologicznych często wykonywane są manualne pomiary rozkładu prędkości gazu w kanałach instalacji gazów odlotowych przy pomocy układów z różnicowo-ciśnieniowymi czujnikami prędkości. Celem jest ustalenie profi lu prędkości osiowej. Przepływy w przekrojach pomiarowych nie zawsze są współosiowe z biegiem kanału; cechują się różnymi kierunkami wektora prędkości w różnych punktach pomiarowych. Ustalanie rzeczywistych kierunków wektorów prędkości lokalnych, dające gwarancję dokładnego obliczenia prędkości osiowych, często nie jest możliwe z technicznego punktu widzenia i pomiar prędkości prowadzi się przy ustawieniu głowicy czujnika równoległym w stosunku do osi i ścian kanału. Wtedy wiedza o czułości kierunkowej zastosowanego czujnika prędkości pozwala albo na wyeliminowanie błędu pomiaru prędkości osiowej, albo na uwzględnienie go poprzez niepewność tego pomiaru. Dla specyfi cznych sytuacji dwuwymiarowej zmienności kierunku wektora prędkości wyznaczono charakterystyki czułości kierunkowej i w konsekwencji charakterystyki błędu trzech przyjętych do badań czujników: pyłowej sondy zerowej o funkcji anemometrycznej jako elementu pyłomierza grawimetrycznego i porównawczo - dwóch powszechnie stosowanych rurek spiętrzających: typu S i L.

  9. A Administração é uma Ciência? Reflexões Epistemológicas acerca de sua Cientificidade

    Directory of Open Access Journals (Sweden)

    Elói Júnior Damke

    2010-12-01

    Full Text Available Este estudo de caráter epistemológico tem como objetivo expor e discutir a questão da cientificidade da administração. Essa discussão já foi realizada em outros estudos, sem ter sido, contudo, a exemplo deste estudo, efetuado por meio da análise dos critérios epistemológicos dos filósofos Karl Popper, Thomas Kuhn e Imre Lakatos. Com base nas correntes epistemológicas apresentadas, pode-se concluir: que a administração, como teoria do conhecimento, pode ser considerada ciência, o que decorre da possibilidade de falsear os estudos dessa área conforme o falseacionismo sofisticado de Popper; que a administração atende aos pressupostos da ciência paradigmática de Kuhn, apesar de não existir consenso sobre em que etapa se encontra e se adéqua aos moldes dos programas de pesquisa apresentados por Lakatos. Sabe-se que a administração ainda possui um longo caminho a percorrer em busca da ampliação de seu rigor metodológico e de seu amadurecimento, mas desconsiderá-la como ciência, além de não auxiliar neste amadurecimento, acaba por desprestigiar um amplo grupo de atores sociais – as organizações – que não são objeto principal de estudo de outras ciências.

  10. Lifetime broadening and CI-resonances observed in ESCA

    International Nuclear Information System (INIS)

    Svensson, S.; Maartensson, N.; Basilier, E.; Malmquist, P.Aa.; Gelius, U.; Siegbahn, K.

    1976-03-01

    The electron spectrum of the M 2 and M 3 levels in bromine and krypton have been studied by high resolution ESCA. The M 1 Msub(2,3) super Coster-Kronig transitions become energetically forbidden for Z >approximately 36 (Kr) and recent calculations therefore predict a decrease in the M 2 and M 3 natural linewidths around krypton in the periodic system. The experiment shows that the 3psub(3/2) linewidth is smaller in Kr than in Br. It is, however, also found that this decrease in linewidth is followed by configuration interaction (CI) between 3p 2 P and 3d 2 nl * 2 P states. Several discrete CI resonances are observed in the Kr 3p spectrum. Such resonances are also studied in the N shell for the elements from Te(Z=52) to Ba(Z=56). For these elements the effect is found to be much larger due to the strong collective character of 4d-nf* excitations. (Auth.)

  11. Comparison of minitrampoline- and full-sized trampoline-related injuries in the United States, 1990-2002.

    Science.gov (United States)

    Shields, Brenda J; Fernandez, Soledad A; Smith, Gary A

    2005-07-01

    To compare mini- and full-sized trampoline-related injuries in the United States. A retrospective analysis of data was conducted for all ages from the National Electronic Injury Surveillance System (NEISS) of the US Consumer Product Safety Commission from 1990 to 2002. We compared 137 minitrampoline-related injuries with 143 full-sized trampoline-related injuries, randomly selected from all full-sized trampoline-related injuries reported to the NEISS during the study period. Patients ranged in age from 1 to 80 years (mean [SD]: 13.9 [17.7]) and 2 to 52 years (mean [SD]: 11.0 [8.0]) for mini- and full-sized trampoline-related injuries, respectively. Most patients were younger than 18 years (82% mini, 91% full-sized). Thirty-two percent of minitrampoline- and 19% of full-sized trampoline-related injuries were to children who were younger than 6 years; girls predominated (63% mini, 51% full-sized). Children who were younger than 6 years were more likely to be injured on a minitrampoline than on a full-sized trampoline, when compared with 6- to 17-year-olds (odds ratio [OR]: 2.43; 95% confidence interval [CI]: 1.33-4.47). The majority of injuries occurred at home (87% mini, 89% full-sized). All patients who were injured on a minitrampoline were treated and released, whereas 5% of patients who were injured on a full-sized trampoline were admitted to the hospital. On minitrampolines, children who were younger than 6 years were at risk for head lacerations (OR: 4.98; 95% CI: 1.71-16.03), and children who were 6 to 17 years were at risk for lower extremity strains or sprains (OR: 6.26; 95% CI: 1.35-59.14). Children who were 6 to 17 years and injured on a full-sized trampoline were at risk for lower extremity strains or sprains (OR: 4.85; 95% CI: 1.09-44.93). Lower extremity strains or sprains were the most common injury sustained by adults (18 years and older; 33% mini, 15% full-sized). Injury patterns were similar for mini- and full-sized trampolines, although

  12. Eclipse in the binary system of the CI Cyg symbiotic star

    Energy Technology Data Exchange (ETDEWEB)

    Belyakina, T S

    1979-01-01

    Photoelectric photometry and spectral observations of the symbiotic star CI Cyg were carried out at the Crimean Astrophysical Observatory from April, 1975 through December, 1976. The instrumental photometric system used was close to the UBV. Considerable light variations and spectral changes have been recorded during the period of the observations. Yellow, blue and ultraviolet amplitudes were equal to 2.3, 3.0 and 3sub(m).3 correspondingly. The brightness of CI Cyg reached maximal value in June - July, 1975 when spectrum was F5 with Hsub(..cap alpha..) and Hsub(..beta..) in emission. A sharp and deep minimum in the light curves of CI Cyg was observed during the period of the highest brightness. It was caused by the eclipse of the hot component by the cold one in the binary system.

  13. Preparation of 1 Ci of europium 155 without carrier

    International Nuclear Information System (INIS)

    Falconi, N.; Radicella, R.

    1968-01-01

    High activity 'point' sources of 155 Eu are used for medical and industrial applications. For this purpose we have studied a method of obtaining I Ci of carrier free 155 Eu, with a solid residue smaller than 5 mg per Ci. In order to separate the 155 Eu from several grams of a 154 Sm enriched target we propose a procedure which is based on the work of Bouissieres and David, Onstott, and Takekoshi et al. The separation is carried out by electrolysis on a mercury cathode followed by purification on ion exchange resin. The yields of the europium separation and target recovery are 80 per cent and 90 per cent respectively. The time required for the procedure is three days. (authors) [fr

  14. Ciência do Esporte no Brasil: reflexões sobre o desenvolvimento das pesquisas, o cenário atual e as perspectivas futuras

    Directory of Open Access Journals (Sweden)

    Luís VIVEIROS

    2015-03-01

    Full Text Available O Brasil foi, recentemente, palco de um dos eventos esportivos mais importantes do mundo, a Copa do Mundo de Futebol de 2014 e, em um futuro próximo, irá sediar os Jogos Olímpicos de Rio 2016. Esses eventos podem ser considerados como uma grande oportunidade para desenvolver a Ciência do Esporte no Brasil. A Ciência do Esporte pode ser definida como o processo científico utilizado para orientar a prática do Esporte, com o objetivo, em última instância, de melhorar o desempenho esportivo. No entanto, apesar deste objetivo, o consenso geral é que aplicação do conhecimento gerado pela Ciência do Esporte na prática ainda é incipiente. Este ensaio revisita o modelo para o desenvolvimento da Ciência do Esporte, proposto anteriormente por Bishop(1 , discute o cenário da Ciência do Esporte no Brasil e também aponta para as perspectivas futuras. As diretrizes do modelo revisitado, em conjunto com as discussões realizadas neste ensaio, podem ajudar o cientista do Esporte a desenvolver estudos aplicados nos quais os resultados poderiam ser utilizados para orientar a prática e, possivelmente, maximizar o desempenho esportivo.

  15.  Syntetyczne instrumenty finansowe i przykłady ich ujęcia w kontekście stosowania kosztu historycznego i wartości godziwej

    Directory of Open Access Journals (Sweden)

    Paweł Bielawski

    2010-11-01

    Full Text Available Celem niniejszego artykułu jest zaprezentowanie koncepcji konstruowania instrumentów syntetycznych na podstawie parytetu opcji kupna i opcji sprzedaży oraz modelu kosztów posiadania. Koncepcje te zostały wykorzystane do skonstruowania strategii long strangle i long straddle na rzeczywistych i syntetycznych instrumentach. Do wyceny bilansowej strategii zastosowano model mieszany wyceny, oparty na dwóch podstawowych miarach wartości instrumentów finansowych: zasadzie kosztu historycznego i kategorii wartości godziwej.

  16. Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.

    Science.gov (United States)

    Li, Qufei; Jogini, Vishwanath; Wanderling, Sherry; Cortes, D Marien; Perozo, Eduardo

    2012-10-16

    The voltage-sensing domain (VSD) is the common scaffold responsible for the functional behavior of voltage-gated ion channels, voltage sensitive enzymes, and proton channels. Because of the position of the voltage dependence of the available VSD structures, at present, they all represent the activated state of the sensor. Yet in the absence of a consensus resting state structure, the mechanistic details of voltage sensing remain controversial. The voltage dependence of the VSD from Ci-VSP (Ci-VSD) is dramatically right shifted, so that at 0 mV it presumably populates the putative resting state. Appropriate biochemical methods are an essential prerequisite for generating sufficient amounts of Ci-VSD protein for high-resolution structural studies. Here, we present a simple and robust protocol for the expression of eukaryotic Ci-VSD in Escherichia coli at milligram levels. The protein is pure, homogeneous, monodisperse, and well-folded after solubilization in Anzergent 3-14 at the analyzed concentration (~0.3 mg/mL). Ci-VSD can be reconstituted into liposomes of various compositions, and initial site-directed spin labeling and electron paramagnetic resonance (EPR) spectroscopic measurements indicate its first transmembrane segment folds into an α-helix, in agreement with the homologous region of other VSDs. On the basis of our results and enhanced relaxation EPR spectroscopy measurement, Ci-VSD reconstitutes essentially randomly in proteoliposomes, precluding straightforward application of transmembrane voltages in combination with spectroscopic methods. Nevertheless, these results represent an initial step that makes the resting state of a VSD accessible to a variety of biophysical and structural approaches, including X-ray crystallography, spectroscopic methods, and electrophysiology in lipid bilayers.

  17. Expression, Purification and Reconstitution of the Voltage Sensing Domain from Ci-VSP

    Science.gov (United States)

    Li, Qufei; Jogini, Vishwanath; Wanderling, Sherry; Cortes, D. Marien; Perozo, Eduardo

    2013-01-01

    The voltage-sensing domain (VSD) is the common scaffold responsible for the functional behavior of voltage gated ion channels, voltage sensitive enzymes and proton channels. Because of the position of the voltage dependence of the available VSD structures, at present, they all represent the activated state of the sensor. Yet, in the absence of a consensus resting state structure, the mechanistic details of voltage sensing remain controversial. The voltage dependence of the VSD from Ci-VSP (Ci-VSD) is dramatically right shifted, so that at 0 mV It presumably populates the putative resting state. Appropriate biochemical methods are an essential prerequisite to generate sufficient amounts of Ci-VSD protein for high-resolution structural studies. Here, we present a simple and robust protocol for the Escherichia coli expression of eukaryotic Ci-VSD at milligram levels. The protein is pure, homogeneous, mono-disperse and well folded after solubilization in Anzergent 3-14 at the analyzed concentration (~ 0.3 mg/mL). Ci-VSD can be reconstituted into liposomes of various compositions and initial site-directed spin labeling and EPR spectroscopic measurements indicate its first transmembrane segment folds into an α-helix, in agreement to the homologous region of other VSDs. Based on current results and enhanced relaxation EPR spectroscopy measurement, Ci-VSD reconstitutes essentially randomly in proteo-liposomes, precluding straightforward application of transmembrane voltages in combination with spectroscopic methods. Nevertheless, the present results represent an initial step that makes the resting state of a VSD accessible to a variety of biophysical and structural approaches, including X-ray crystallography, spectroscopic methods and electrophysiology in lipid bilayers. PMID:22989304

  18. Pluralismo metodológico no ensino de ciências Methodological pluralism in science teaching

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Laburú

    2003-01-01

    Full Text Available Inspirados numa leitura epistemológica feyerabendiana, este trabalho sugere uma abordagem metodológica pluralista para o ensino das ciências. Defendemos que esse estratagema didático seja potencialmente mais eficaz para a aprendizagem, na medida em que procura dar conta do espectro de questões que se apresentam na sala de aula.Inspired by an epistemological reading of Feyerabend, this paper proposes a pluralist methodological approach to science teaching. We propose that this didactic strategy is potentially more effective in the learning process because it tries to account for the spectrum of questions that are presented in the classroom.

  19. Charakterystyka opadów atmosferycznych w centralnej części Pojezierza Kaszubskiego w latach 1971–2010

    Directory of Open Access Journals (Sweden)

    Mirosława Malinowska

    2015-10-01

    Full Text Available Artykuł prezentuje podstawowe charakterystyki opadu atmosferycznego w północno-wschodniej części Pojezierza Pomorskiego. Roczne sumy opadu przyjmują wartości od około 660 mm do około 700 mm. Opady półrocza ciepłego szacowane są na około 400 mm a opady półrocza chłodnego na około 270 mm. Dominują opady w sezonie letnim (212 - 233 mm. Opady jesieni (173 – 189 mm przewyższają opady wiosny i zimy (133 – 153 mm co dowodzi wpływu Morza Bałtyckiego na stosunki pluwialne obszaru badań. Lata 1971-2010 charakteryzowały się pozytywnymi tendencjami zmian sum rocznych, półrocznych i sezonowych opadu atmosferycznego.

  20. CiOpt: a program for optimization of the frequency response of linear circuits

    OpenAIRE

    Miró Sans, Joan Maria; Palà Schönwälder, Pere

    1991-01-01

    An interactive personal-computer program for optimizing the frequency response of linear lumped circuits (CiOpt) is presented. CiOpt has proved to be an efficient tool in improving designs where the inclusion of more accurate device models distorts the desired frequency response, as well as in device modeling. The outputs of CiOpt are the element values which best match the obtained and the desired frequency response. The optimization algorithms used (the Fletcher-Powell and Newton's methods,...

  1. O retrato da ciência da informação: uma análise de seus fundamentos sociais 10.5007/1518-2924.2007v12n23p133

    Directory of Open Access Journals (Sweden)

    Leonardo Vasconcelos Renault

    2007-12-01

    Full Text Available Apresenta a fundamentação social da ciência da informação através de três autores da área:Capurro, Shera e Wersig. Em cada um dos autores procurou-se identificar traços que contribuiriam para a fundamentação da Ciência da Informação como uma ciência com características sociais. Segue-se uma argumentação de cunho epistemológico acerca da possibilidade da Ciência da Informação, como ciência social, avançando na definição de seu objeto mediante comparação com a área de Comunicação Social. Por fim, uma última imagem, da ordem da metáfora tenta posicionar a Ciência da Informação, como ciência social com características hermenêuticas.

  2. Contribuições para o estudo do ciúme excessivo

    OpenAIRE

    Andrea Lorena da Costa

    2010-01-01

    O ciúme romântico é um complexo de pensamentos, emoções e ações que visam proteger o relacionamento diante de uma ameaça percebida real ou imaginária e tem como objetivo eliminar os riscos da perda do objeto de amor. O ciúme excessivo (patológico) é uma preocupação infundada, irracional e irreal, composto de diversas emoções e pensamentos que provocam prejuízos significativos no funcionamento pessoal e relacional. O objetivo deste trabalho foi explorar a presença de transtornos psiquiátrico...

  3. Effect of Inhomogeneous Mixture Properties on CI Combustion in a Schnurle-Type Gasoline DI Engine

    Science.gov (United States)

    Kim, Seok-Woo; Moriyoshi, Yasuo

    The authors have performed experiments on compression-ignition (CI) for a single-cylinder Schnurle-type two-stroke gasoline direct injection (DI) engine which employs a variable exhaust port, area, and deduced two presumptions from the experimental results. Firstly, the spatial distributions of fuel concentration and in-cylinder gas temperature are indispensable to enable CI operation under stratified charge conditions, because CI operation is not possible in a DI system although the necessary conditions of the scavenging efficiency and the in-cylinder gas temperature for the initiation of CI in homogeneous charge conditions are satisfied. Secondly, it is possible that flame propagation occurs in stratified charge CI conditions, because the combustion period in the later stage after 80% mass burned becomes longer than that with homogeneous charge CI combustion. In this report, in order to verify the above two presumptions deduced from experiments, the gas exchange process and mixture formation process were numerically analyzed, and the initiation conditions of CI were estimated using a CHEMKIN application. As a result, in case of CI with a late injection timing in DI system, it was found that CI was possible because high temperature but no fuel region and low temperature but rich fuel region exist in the cylinder due to inhomogeneous spatial distributions of fuel and temperature. Also, in case of CI with a late injection timing, the flame propagation was possible in the low-temperature and diluted rich region. Thereby, the two presumptions deduced from the experimental results were validated from the numerical analysis results.

  4. Calculation of particle dynamics in CI-10 cyclotron

    International Nuclear Information System (INIS)

    Samsonov, E.V.; Karamysheva, G.A.; Vorozhtsov, S.B.

    1999-01-01

    The calculations of beam dynamic characteristics of High-Intensity Cyclotron-Injector CI-10 for deuteron beam of 15 MeV energy are presented. Analytical estimations of space charge effects are given. In order to increase the intensity of the accelerator beam some ideas about the cyclotron design modification are given too. (author)

  5. An Experimental Research on the pCI Rule and Causal Judgment (in Chinese)

    OpenAIRE

    Shao, Z. F.; Wang, J.

    2005-01-01

    This research examined the precision of the pCI rule through three experiments. The results show that first , the tendency of the subjects’ casual judgments was basically similar to the pCI rule. But (a + d) / n predicted human’s casual judgments were even better; second, the increase of subjects’ casual judgments was milder than the pCI rule, and the subjects needed time to construct their own way of judging relationship; finally, different people had different ways of causal judgments, and ...

  6. Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

    Science.gov (United States)

    Ohtsu, Atsushi; Ajani, Jaffer A.; Bai, Yu-Xian; Bang, Yung-Jue; Chung, Hyun-Cheol; Pan, Hong-Ming; Sahmoud, Tarek; Shen, Lin; Yeh, Kun-Huei; Chin, Keisho; Muro, Kei; Kim, Yeul Hong; Ferry, David; Tebbutt, Niall C.; Al-Batran, Salah-Eddin; Smith, Heind; Costantini, Chiara; Rizvi, Syed; Lebwohl, David; Van Cutsem, Eric

    2013-01-01

    Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months with everolimus and 4.3 months with placebo (hazard ratio, 0.90; 95% CI, 0.75 to 1.08; P = .124). Median PFS was 1.7 months and 1.4 months in the everolimus and placebo arms, respectively (hazard ratio, 0.66; 95% CI, 0.56 to 0.78). Common grade 3/4 adverse events included anemia, decreased appetite, and fatigue. The safety profile was similar in patients enrolled in Asia versus ROW. Conclusion Compared with BSC, everolimus did not significantly improve overall survival for advanced gastric cancer that progressed after one or two lines of previous systemic chemotherapy. The safety profile observed for everolimus was consistent with that observed for everolimus in other cancers. PMID:24043745

  7. Risk factors for overuse shoulder injuries in a mixed-sex cohort of 329 elite handball players: previous findings could not be confirmed.

    Science.gov (United States)

    Andersson, Stig Haugsboe; Bahr, Roald; Clarsen, Benjamin; Myklebust, Grethe

    2017-08-07

    Shoulder injuries are common among handball players and predominantly characterised by overuse characteristics. Reduced total glenohumeral rotation, external rotation weakness and scapular dyskinesis have been identified as risk factors among elite male handball players. To assess whether previously identified risk factors are associated with overuse shoulder injuries in a large cohort of elite male and female handball players. 329 players (168 male, 161 female) from the two upper divisions in Norway were included and tested prior to the 2014-2015 season. Measures included glenohumeral internal and external rotation range of motion, isometric internal and external rotation strength, and assessment of scapular dyskinesis. Players were followed prospectively for one competitive season, with prevalence and severity of shoulder problems registered monthly using the Oslo Sports Trauma Research Center Overuse Injury Questionnaire. A severity score based on players' questionnaire responses was used as the outcome measure in multivariable logistic regression to investigate associations between candidate risk factors and overuse shoulder injury. No significant associations were found between total rotation (OR 1.05 per 5° change, 95% CI 0.98 to 1.13), external rotation strength (OR 1.05 per 10 N change, 95% CI 0.92 to 1.20) or obvious scapular dyskinesis (OR 1.23, 95% CI 0.25 to 5.99) and overuse shoulder injury. A significant positive association was found between greater internal rotation (OR 1.16 per 5° change, 95% CI 1.00 to 1.34) and overuse shoulder injury. None of the previously identified risk factors were associated with overuse shoulder injuries in a mixed-sex cohort of elite handball players. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. Potrzeby i możliwości rehabilitacji chorych na stwardnienie rozsiane w Polsce

    Directory of Open Access Journals (Sweden)

    Andrzej Potemkowski

    2015-08-01

    Full Text Available Specyfika stwardnienia rozsianego sprawia, że rehabilitacja pacjentów cierpiących na tę chorobę jest jednym z najtrudniejszych zadań rehabilitacji neurologicznej. Liczne objawy stwardnienia rozsianego znacznie obniżają jakość życia około 40 000 chorych żyjących w Polsce. Choć rehabilitacja nie zmniejsza istotnie częstości rzutów ani nie zatrzymuje progresji choroby, to – jeśli jest odpowiednio, nowocześnie prowadzona – poprawia nie tylko obiektywne wskaźniki, lecz także subiektywne samopoczucie i samoocenę, a w rezultacie daje możliwość wytworzenia pozytywnego obrazu siebie. Potrzeby polskich chorych są duże, ale dostępność rehabilitacji (zarówno ambulatoryjnej, jak i  stacjonarnej jest wysoce niesatysfakcjonująca. W związku z tym powinno się optymalizować jakość rehabilitacji prowadzonej przez chorych samodzielnie, w warunkach domowych. Duże znaczenie mają zatem wiedza pacjenta na temat wpływu rehabilitacji na chorobę i możliwych form leczniczych, jak również świadomość skutków zaniechania tej formy leczenia. Stwardnienie rozsiane, niezależnie od postaci, prowadzi do niepełnosprawności i obniżenia jakości życia, a to ogranicza samodzielność, niesie ze sobą ryzyko utraty pracy, utrudnia samoobsługę i swobodę w zakresie aktywności dnia codziennego. Istotna staje się rola rehabilitacyjnych zespołów terapeutycznych (specjaliści neurologii i rehabilitacji plus fizjoterapeuta, które powinny istnieć w każdej poradni diagnostyki i leczenia stwardnienia rozsianego. Ustalenie przez taki zespół ubytków funkcji oraz określenie celów i planu postępowania pozwoliłyby na zmniejszanie skutków postępu choroby.

  9. KONDENSACJA W PRZEGRODZIE ŚCIENNEJ Z KOMPOZYTU WAPIENNO-KONOPNEGO – OCENA MOŻLIWOŚCI WYSTĄPIENIA

    Directory of Open Access Journals (Sweden)

    Przemysław BRZYSKI

    Full Text Available Obecność składników organicznych w materiałach budowlanych, decyduje o ich wrażliwości na wilgoć, a dłuższej perspektywie na ich korozję biologiczną, jeśli nie zostaną odpowiednio zabezpieczone przed czynnikami atmosferycznymi. Przegrody powinno się projektować zwracając uwagę na ryzyko wystąpienia powierzchniowej oraz międzywarstwowej kondensacji pary wodnej. W artykule przedstawiono analizę przegrody ściennej, wykonanej z kompozytu wapienno-konopnego. Założono grubość ściany 40 cm oraz po 2 cm tynku po obu stronach. Kompozyt składa się z modyfikowanego spoiwa wapiennego oraz paździerzy konopnych pozyskanych z konopi przemysłowych. Parametry materiału, potrzebne do analizy (współczynnik przewodności cieplnej oraz paroprzepuszczalność wyznaczono doświadczalnie w badaniach własnych. W części analitycznej artykułu przedstawiono obliczenia temperatury powierzchni koniecznej do uniknięcia krytycznej wilgotności powierzchni wewnętrznej ściany oraz określono możliwość wystąpienia kondensacji międzywarstwowej w analizowanej ścianie. Obliczenia wykonano zgodnie z normą PN-EN 13788. Przyjęto warunki brzegowe dla lokalizacji Lublin. Miesiącem krytycznym, w którym przegroda jest najbardziej narażona na kondensację jest styczeń. Z uwagi na dobre parametry termoizolacyjne przegrody, jej budowę ryzyko rozwoju pleśni na wewnętrznej powierzchni ściany nie występuje. Kondensacja wewnętrzna występuje w przegrodzie w okresie grudzień – luty. Natomiast już w marcu zgromadzony kondensat ulega całkowitemu odparowaniu. Przegroda odpowiedniej grubości, wykonana z kompozytu wapienno-konopnego, z uwagi na swoją wysoką paroprzepuszczalność oraz niskie przewodnictwo cieplne nie jest narażona na długotrwałe i niszczące oddziaływanie skraplającej się wewnątrz pary wodnej.

  10. Miguel de Unamuno. Pomiędzy fikcją a rzeczywistością

    Directory of Open Access Journals (Sweden)

    Agnieszka Kłosińska-Nachin

    2007-11-01

    Full Text Available The article Miguel de Unamuno. Pomiędzy fikcją a rzeczywistością (Miguel de Unamuno. Between fiction and reality is an author's metalepsy analysis, a phenomenon described by Gerard Cenette (Mśtalepse. De la figurę k la fiction, 2004, in three texts by Miguel de Unamuno: Vida de Don Quijote y Sancho (1905, Niebla (1914 and Cómo se hace una novela (1927. Author's metalepsy, defined as transgression of the limits of fiction by an author, existentional metalepsy (understood as a vision of the world based on doubt, concerning the status of reality and reader's metalepsy (if he’s forced to transgression of the limits of fiction are the inseparable parts of Unamuno's writing.

  11. A reconstrução da realidade nas Ciências Sociais

    Directory of Open Access Journals (Sweden)

    Florestan Fernandes

    2004-07-01

    Full Text Available Nota dos editores: O artigo "A reconstrução da realidade nas Ciências Sociais" foi publicado originalmente em duas partes. A primeira apareceu no número 82 da Revista Anhembi conforme a nota explicativa do texto. A segunda parte foi publicada no número 83 da mesma Revista, que saiu no mês de outubro de 1957. As duas partes do artigo foram publicadas como um capítulo do livro de Florestan Fernandes, "Fundamentos Empíricos da Explicação Sociológica", editado pela Cia. Ed. Nacional em 1959. A Editora Ática republicou o artigo completo no livro "Florestan Fernandes – Coleção Grandes Cientistas Sociais", organizado por Octavio Ianni em 1986. A Revista Mediações, mediante autorização, publica a primeira parte do artigo apresentado no número 82 da Revista Anhembi. As notas aparecem numeradas no texto entre parênteses.

  12. Construindo pontes entre ciência, política e práticas em saúde coletiva

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Magalhães Bosi

    2011-12-01

    Full Text Available O artigo analisa elementos nucleares no debate nacional e internacional acerca da necessária integração entre ciência, política e práticas em Saúde Coletiva e apresenta subsídios para essa integração. São assinalados alguns obstáculos situados tanto no plano conceitual como aqueles presentes nas relações que se processam em outras esferas e se interpõem à pretendida integração. Dentre os elementos assinalados, evidencia-se que ciência, política e o âmbito das práticas no setor não são campos homogêneos nem tampouco contínuos, implicando relações situadas em diferentes planos e envolvendo diferentes atores. Tais processos desenvolvem-se em arenas distintas, sustentados igualmente por distintas ações, paradigmas e interesses, não isentos de conflitos. Portanto, tal integração é um desafio de grande magnitude, dada sua complexidade e diversidade, objetiva e subjetiva.

  13. High-Performance Wireless via the Merger of CI Chip-Shaped DS-CDMA and Oscillating-Beam Smart Antenna Arrays

    Directory of Open Access Journals (Sweden)

    Nassar Carl R

    2004-01-01

    Full Text Available We introduce a novel merger of direct sequence code division multiple access (DS-CDMA and smart antenna arrays. With regard to the DS-CDMA scheme, we employ carrier interferometry DS-CDMA (CI/DS-CDMA, a novel implementation of DS-CDMA where chips are decomposable into narrowband frequency components. With regard to the antenna array, we deploy the oscillating-beam smart array. Here, applying proper time-varying phases to the array elements, we create small movement (oscillation in the antenna array's pattern, while steering the antenna pattern main lobe to the position of the intended user. The oscillating antenna pattern creates a time-varying channel with a controllable coherence time. This, in turn, provides transmit diversity in the form of a time diversity gain at the mobile receiver side. At the receiver, three stages of combining are available: combining time components of the received signal within symbol duration (each experiencing a different fade to enhance performance via time diversity; combining frequency components which make up the CI/DS-CDMA chip to enhance the performance via frequency diversity; and combining across chips to eliminate the interfering users on the system. Merging CI/DS-CDMA with the oscillating-beam smart antenna at the base station, we achieve very high capacity via the merger of SDMA (available through directionality of the antenna array and code division multiple access (inherent in CI/DS-CDMA, and very high performance via the construction of receivers that exploit both transmit diversity and frequency diversity. We present the performance gains of the proposed merger.

  14. Outcome after arthroscopic labral surgery in patients previously treated with periacetabular osteotomy

    DEFF Research Database (Denmark)

    Hartig-Andreasen, Charlotte; Nielsen, Torsten G; Lund, Bent

    2017-01-01

    To identify factors predicting failure after hip arthroscopy in patients with previous periacetabular osteotomy (PAO) defined as a conversion to total hip replacement (THR) and to evaluate the patient reported outcome scores. Of 55 hips treated with hip arthroscopy after PAO from Aug 2008 to 2012....... Nine hips were converted to a THR. Kaplan-Meier survival rate was 52.8% (95% CI, 10%-83.8%) at 6.5 years follow-up. Statistically significant predictors of failure: joint space width after PAO ...% of the hips. In 42% of the hips cartilage lesions of Becks grade >3 were found. Mean mHHS and HOS were 65.7 and 68.8 respectively at follow-up. A NRS pain score of >3 in rest and during activity were present in respectively, 43% and 62% of the patients. Hip arthroscopy after PAO demonstrated limited clinical...

  15. Dual inhibitory action of enadoline (CI977) on release of amino acids in the rat hippocampus.

    Science.gov (United States)

    Millan, M H; Chapman, A G; Meldrum, B S

    1995-06-06

    The effect of the kappa-opioid receptor agonist enadoline (CI977, (5R)-(5 alpha,7 alpha,8 beta)-N-methyl-N-[7-(1-pyrrilidinyl)-1-oxaspiro [4,5]dec-8-yl-4-benzofuranacetamide monohydrochloride), on the release of amino acids was studied in the hippocampus of freely moving rats. K+, 100 mM, or veratrine, 100 microM, were applied for 10 min via the dialysis probe, either alone (control groups) or together with CI977 (after a 10 min pretreatment with CI977 in the perfusion medium). To test the specificity of the response to CI977, nor-binaltorphimine, a selective kappa-opioid receptor antagonist, was delivered together with CI977 in two groups of animals. To test the effect of systemic injection, CI977 was given subcutaneously 30 min prior to either stimulus. K(+)-induced release of glutamate and aspartate was significantly reduced by CI977, 2.5 mM; release of gamma-aminobutyric acid (GABA) was reduced by 250 microM CI977 in the probe. The effect of CI977 on release of glutamate and aspartate, but not of GABA, was reversed by nor-binaltorphimine (45 microM). Systemic treatment with CI977, 1 or 10 mg/kg, did not reduce K(+)-induced release of glutamate. Veratrine-induced release of aspartate and glutamate was significantly inhibited by 25 microM and release of GABA by 250 microM CI977 in the probe, and this effect was not modified by nor-binaltorphimine (58 microM). Systemic injection of CI977 1 mg/kg significantly reduced veratrine-induced release of glutamate. These results indicate that CI977 regulates release of amino acids by two independent mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Os Congressos Brasileiros de Ciências Sociais e Humanas em Saúde da Abrasco: um campo científico em disputa

    Directory of Open Access Journals (Sweden)

    Aurea Maria Zöllner Ianni

    2015-02-01

    Full Text Available Atualmente, no Brasil, configura-se um pensamento social em saúde, como campo científico, político e atuante: Estudar os Congressos de Ciências Sociais em Saúde da Abrasco representa realizar uma genealogia parcial da área, apreendendo como se deu a constituição desse subcampo e seu desenvolvimento, além de mapear o atual ‘estado da arte’ dessa área de conhecimento. Este artigo analisa as falas de informantes-chave sobre as realizações dos Congressos. São 13 entrevistas com presidentes da Abrasco e coordenadores das Comissões de Ciências Sociais, em diferentes gestões – anos de realização dos Congressos Brasileiros de Ciências Sociais e Humanas em Saúde, entre 1995 e 2011. Os depoimentos permitiram identificar três momentos marcantes da realização dos Congressos: o primeiro, em 1995, quando da realização do I Congresso, que significou a maturação do conhecimento das ciências sociais em saúde, a demarcação do campo; o III Congresso, de 2005, referido como o de consolidação da área de conhecimento, de consolidação desse campo científico; e o V Congresso, de 2011, que pôs em pauta o lugar científico das ciências sociais e humanas em saúde no contexto da Saúde Coletiva, no Brasil.

  17. Polityka rachunkowości w praktyce jednostek gospodarczych w kontekście jej oceny przez biegłych rewidentów

    Directory of Open Access Journals (Sweden)

    Katarzyna Świetla

    2017-07-01

    Full Text Available Ramowy charakter regulacji prawa bilansowego umożliwia jednostkom gospodarczym świadome prowadzenie polityki rachunkowości, które pozwala na kreowanie obrazu przedsiębiorstwa, a tym samym na realizację jego celów i założeń gospodarczych. W artykule, na podstawie analizy literatury przedmiotu i aktów prawnych przedstawiono współczesne problemy związane z tworzeniem polityki rachunkowości i jej dostosowywaniem do indywidualnych potrzeb jednostek gospodarczych. Zaprezentowano także wyniki badań ankietowych przeprowadzonych na grupie polskich biegłych rewidentów. W ich opinii jednostki gospodarcze częściej wykorzystują instrumenty polityki rachunkowości w celu świadomego i celowego kreowania obrazu przedsiębiorstwa, niż w rozmyślnym fałszowaniu sprawozdań finansowych. Autorzy zwracają uwagę na wzrost znaczenia zewnętrznych jednostek konsultingowych w tworzeniu i dostosowywaniu polityki rachunkowości do potrzeb jednostek. Przeprowadzone rozważania skłaniają także do zmiany postrzegania roli biegłego rewidenta w badaniu polityki rachunkowości. W opinii autorów, potwierdzonej wynikami badań, biegły rewident powinien nie tylko sprawdzać zgodność przyjętych rozwiązań z prawem bilansowym, ale też oceniać ich celowość i zasadność w konkretnej sytuacji danej jednostki.

  18. Treści bibliologiczne na łamach „Łowca Polskiego” w latach 1989–2011

    Directory of Open Access Journals (Sweden)

    Danuta Wańka

    2012-01-01

    Full Text Available W artykule przedstawiono problematykę bibliologiczną w świetle 23 roczników „Łowca Polskiego” (1989–2011 ukazującego się od 1899 roku. Po krótkiej prezentacji dziejów i zawartości pisma opisano i zacytowano fragmenty tekstów o charakterze bibliologicznym. Niektóre z nich przytoczono ze szczegółami, traktując je jako materiały źródłowe, ważne dla badań nad kulturą książki.

  19. Previous Education, Sociodemographic Characteristics, and Nursing Cumulative Grade Point Average as Predictors of Success in Nursing Licensure Examinations

    Directory of Open Access Journals (Sweden)

    Isaac Amankwaa

    2015-01-01

    Full Text Available Introduction. Success in the licensure examination is the only legal prerequisite to practice as a nurse in Ghana. However, a large percentage of nursing students who sit fail this examination for the first time. This study sought to unravel whether prior education, sociodemographic characteristics, and nursing Cumulative Grade Point Average (CGPA could predict performance in the licensure examinations. Methods. The study was a descriptive cross-sectional survey conducted from November 2014 to April 2015 in the Kumasi metropolis, Ghana on 176 past nursing students. Data was collected using questionnaires and analyzed using SPSS version 22. A logistic regression model was fitted to look at the influence of the explanatory variables on the odds of passing the licensure examinations. All statistical significances were tested at p value of <0.05. Results. Majority, 56.3%, were females and 86.4% were between the ages of 25 and 31 years. Most of the students (88.6% entered the nursing training colleges with a WASSCE qualification and 38% read general science. 73.9% passed the licensure examinations and the mean CGPA of the students was 2.89 SD=0.37. Sociodemographic characteristics and previous education had no influence on performance in the licensure examinations. CGPA had strong positive relationship with performance in licensure examinations (AOR = 15.27; 95% CI = 6.28, 27.11. Conclusion. Students CGPA could be a good predictor of their performance in the licensure examinations. On the other hand, students’ sociodemographic and previous educational characteristics might not be important factors to consider in admitting students into the nursing training programme.

  20. Rapid Discrimination of Chlorpheniramine Maleate and Assessment of Its Surface Content Uniformity in a Pharmaceutical Formulation by NIR-CI Coupled with Statistical Measurement

    Directory of Open Access Journals (Sweden)

    Luwei Zhou

    2014-01-01

    Full Text Available This study demonstrated that near infrared chemical imaging (NIR-CI was a rapid and nondestructive technique for discrimination of chlorpheniramine maleate (CPM and assessment of its surface content uniformity (SCU in a pharmaceutical formulation. The characteristic wavenumber method was used for discriminating CPM distribution on the tablet surface. To assess the surface content uniformity of CPM, binary image and statistical measurement were proposed. Furthermore, high-performance liquid chromatography (HPLC was used as reference method for accurately determining volume content of CPM in the sample. Moreover, HPLC was performed to assess volume content uniformity (VCU of CPM in whole region and part region of the tablets. The NIR-CI result showed that the spatial distribution of CPM was heterogeneous on the tablet surface. Through the comparison of content uniformity of CPM determined by NIR-CI and HPLC, respectively, it demonstrated that a high degree of VCU did not imply a high degree of SCU of the samples. These results indicate that HPLC method is not suitable for testing SCU, and this has been verified by NIR-CI. This study proves the feasibility of NIR-CI for rapid discrimination of CPM and assessment of its SCU, which is helpful for the quality control of commercial CPM tablets.

  1. A ciência e a tecnologia para os estudantes brasileiros : percepções

    OpenAIRE

    da Cunha, Marcia Borin

    2013-01-01

    Nos anos de 2010 e 2011 realizamos uma pesquisa nacional para verificar as percepções dos estudantes brasileiros sobre temas relacionados à ciência e tecnologia. Esta investigação buscou averiguar como os jovens em idade escolar (Ensino Médio) percebem a ciência e a tecnologia em suas vidas, considerando-se que estas percepções têm influencia na formação dos conceitos científicos escolares e na forma como os jovens relacionam-se com a ciência (Teoria Sociocultural de Vygotsky). Os resultados ...

  2. Qual ciência na educação não formal? Com a palavra as exposições e a divulgação na internet de museus e centros de ciências brasileiros.

    OpenAIRE

    Figueirôa, Silvia Fernanda de Mendonça

    2018-01-01

    Apresentam-se concepções de ciência identificadas em quatro instituições de Educação Não Formal, objeto de pesquisa já concluída: Museu da Vida (RJ), Espaço Ciência (PE), Museu de Ciência e Tecnologia da PUCRS (RS) e Estação Ciência (SP). Analisaram-se seus sites, com metodologia de análise de conteúdo, e suas exposições, com as seguintes categorias definidas a posteriori: Interatividade, Representação Científica e Display. Os resultados apontam tendências das concepções de ciência presentes ...

  3. Artigos da revista Ciência Hoje como recurso didático no ensino de química

    Directory of Open Access Journals (Sweden)

    Luciana Nobre de Abreu Ferreira

    2011-01-01

    Full Text Available This paper presents the results from the selection and analysis of Ciência Hoje articles published from 2004 to 2009 with the aim to discuss some of their features which can assist teachers in chemistry teaching. Therefore, the articles were analyzed according to their content and format based on an analytical tool proposed by Kawamura and colleagues. The results indicate that this magazine offers a reasonable collection of articles related to chemistry with a variety of contents and approaches.

  4. Incognito ergo sum. O wytwarzaniu obojętności

    Directory of Open Access Journals (Sweden)

    Joanna Tokarska-Bakir

    2014-06-01

    Full Text Available Incognito ergo sum: on indifference  The present article is an analysis of various types of indifference of non-Jewish inhabitants of Warsaw to the plight of Jewish Poles. The words of Krzysztof Dunin-Wąsowicz, a historian and “Żegota” activist, provide the vantage point for the analysis: Dunin-Wąsowicz claimed that around 75 per cent of the inhabitants of Warsaw “were indifferent to what was taking place behind the Ghetto wall”. Thomas Kuhne hypothesised that it was Germans’ indifference to the Jewish – not hatred – that legitimised the Nazi racial policies of the 1930s. This statement might also apply to the “75 per cent of the inhabitants of Warsaw”. The article is mainly based on articles published by ZWZ-AK, in particular Biuletyn Informacyjny.   Incognito ergo sum. O wytwarzaniu obojętności Autorka analizuje różne odcienie obojętności nieżydowskich mieszkańców Warszawy w latach czterdziestych wobec losu żydowskich Polaków. Punktem wyjścia jest zdanie Krzysztofa Dunin-Wąsowicza, historyka i działacza „Żegoty”, który stwierdził, że dla około 75 procent mieszkańców Warszawy „obojętne było to, co działo się poza murem getta”. Powołując się na tezę Thomasa Kuhnego, że to właśnie obojętność Niemców wobec Żydów – a nie nienawiść w stosunku do nich – „spowodowała masowe poparcie nazistowskiej polityki rasowej w latach trzydziestych”, autorka zastanawia się, czy „podobnej opinii nie można by sformułować pod adresem” 75 procent mieszkańców Warszawy. Materiał do analizy stanowią w znacznej mierze publikacje prasy ZWZ-AK, w tym przede wszystkim „Biuletyn Informacyjny”.

  5. Relações interdisciplinares entre a Ciência da Informação e a Ciência da Comunicação: uma análise a partir de citações, formação das bancas e palavras-chave das teses das áreas

    Directory of Open Access Journals (Sweden)

    João de Melo Maricato

    Full Text Available RESUMO Estuda relações interdisciplinares nas e entre as áreas de Ciência da Informação e da Ciência da Comunicação, discutindo as mudanças de paradigmas que têm acontecido nessas disciplinas. Analisa as relações interdisciplinares com métodos bibliométricos e cientométricos, especificamente análises de coocorrência e cocitação. Coletou-se dados de teses de 4 programas de pós-graduação brasileiros (10 teses de cada um dos programas e analisou-se relações entre as citações, entre a titulação da banca e entre as palavras-chave, com intuito de identificar coocorrências e, consequentemente, relações interdisciplinares nas e entre as duas áreas. Constatou-se que existem fortes relações quanto à análise de cocitação; grande variedade de formações dos membros das bancas e relativamente alta coocorrência destas entre as áreas, porém, mais intensas na área de Ciência da Informação e com mais interesse desta na área Ciência da Comunicação; não foram identificadas relações entre as duas áreas por meio da análise de coocorrência de palavras-chave. Conclui-se que ambas as áreas possuem características fortemente interdisciplinares, no entanto, são mais intensas da área de Ciência da Informação do que da Ciência da Comunicação, havendo mais interesse da primeira área na segunda.

  6. Do emotional intelligence and previous caring experience influence student nurse performance? A comparative analysis.

    Science.gov (United States)

    Stenhouse, Rosie; Snowden, Austyn; Young, Jenny; Carver, Fiona; Carver, Hannah; Brown, Norrie

    2016-08-01

    Reports of poor nursing care have focused attention on values based selection of candidates onto nursing programmes. Values based selection lacks clarity and valid measures. Previous caring experience might lead to better care. Emotional intelligence (EI) might be associated with performance, is conceptualised and measurable. To examine the impact of 1) previous caring experience, 2) emotional intelligence 3) social connection scores on performance and retention in a cohort of first year nursing and midwifery students in Scotland. A longitudinal, quasi experimental design. Adult and mental health nursing, and midwifery programmes in a Scottish University. Adult, mental health and midwifery students (n=598) completed the Trait Emotional Intelligence Questionnaire-short form and Schutte's Emotional Intelligence Scale on entry to their programmes at a Scottish University, alongside demographic and previous caring experience data. Social connection was calculated from a subset of questions identified within the TEIQue-SF in a prior factor and Rasch analysis. Student performance was calculated as the mean mark across the year. Withdrawal data were gathered. 598 students completed baseline measures. 315 students declared previous caring experience, 277 not. An independent-samples t-test identified that those without previous caring experience scored higher on performance (57.33±11.38) than those with previous caring experience (54.87±11.19), a statistically significant difference of 2.47 (95% CI, 0.54 to 4.38), t(533)=2.52, p=.012. Emotional intelligence scores were not associated with performance. Social connection scores for those withdrawing (mean rank=249) and those remaining (mean rank=304.75) were statistically significantly different, U=15,300, z=-2.61, p$_amp_$lt;0.009. Previous caring experience led to worse performance in this cohort. Emotional intelligence was not a useful indicator of performance. Lower scores on the social connection factor were associated

  7. Communication: CDFT-CI couplings can be unreliable when there is fractional charge transfer

    International Nuclear Information System (INIS)

    Mavros, Michael G.; Van Voorhis, Troy

    2015-01-01

    Constrained density functional theory with configuration interaction (CDFT-CI) is a useful, low-cost tool for the computational prediction of electronic couplings between pseudo-diabatic constrained electronic states. Such couplings are of paramount importance in electron transfer theory and transition state theory, among other areas of chemistry. Unfortunately, CDFT-CI occasionally fails significantly, predicting a coupling that does not decay exponentially with distance and/or overestimating the expected coupling by an order of magnitude or more. In this communication, we show that the eigenvalues of the difference density matrix between the two constrained states can be used as an a priori metric to determine when CDFT-CI are likely to be reliable: when the eigenvalues are near 0 or ±1, transfer of a whole electron is occurring, and CDFT-CI can be trusted. We demonstrate the utility of this metric with several illustrative examples

  8. Communication: CDFT-CI couplings can be unreliable when there is fractional charge transfer

    Energy Technology Data Exchange (ETDEWEB)

    Mavros, Michael G.; Van Voorhis, Troy, E-mail: tvan@mit.edu [Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139 (United States)

    2015-12-21

    Constrained density functional theory with configuration interaction (CDFT-CI) is a useful, low-cost tool for the computational prediction of electronic couplings between pseudo-diabatic constrained electronic states. Such couplings are of paramount importance in electron transfer theory and transition state theory, among other areas of chemistry. Unfortunately, CDFT-CI occasionally fails significantly, predicting a coupling that does not decay exponentially with distance and/or overestimating the expected coupling by an order of magnitude or more. In this communication, we show that the eigenvalues of the difference density matrix between the two constrained states can be used as an a priori metric to determine when CDFT-CI are likely to be reliable: when the eigenvalues are near 0 or ±1, transfer of a whole electron is occurring, and CDFT-CI can be trusted. We demonstrate the utility of this metric with several illustrative examples.

  9. Communication: CDFT-CI couplings can be unreliable when there is fractional charge transfer

    Science.gov (United States)

    Mavros, Michael G.; Van Voorhis, Troy

    2015-12-01

    Constrained density functional theory with configuration interaction (CDFT-CI) is a useful, low-cost tool for the computational prediction of electronic couplings between pseudo-diabatic constrained electronic states. Such couplings are of paramount importance in electron transfer theory and transition state theory, among other areas of chemistry. Unfortunately, CDFT-CI occasionally fails significantly, predicting a coupling that does not decay exponentially with distance and/or overestimating the expected coupling by an order of magnitude or more. In this communication, we show that the eigenvalues of the difference density matrix between the two constrained states can be used as an a priori metric to determine when CDFT-CI are likely to be reliable: when the eigenvalues are near 0 or ±1, transfer of a whole electron is occurring, and CDFT-CI can be trusted. We demonstrate the utility of this metric with several illustrative examples.

  10. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed. Copyright © 2015 John Wiley & Sons, Ltd.

  11. FEEDING DIFFICULTIES IN PRESCHOOL CHILDREN, PREVIOUS FEEDING PRACTICES, AND NUTRITIONAL STATUS.

    Science.gov (United States)

    Maranhão, Hélcio de Sousa; Aguiar, Renata Cunha de; Lira, Débora Teixeira Jales de; Sales, Mônica Úrsula Figuerêdo; Nóbrega, Nathalia Ávila do Nascimento

    2018-01-01

    To identify the prevalence of feeding difficulties in preschoolers, its association with epidemiological factors and previous eating habits, and repercussion on nutritional status. Cross-sectional study with a questionnaire given to the mothers of 301 children aged 2-6 years enrolled in public and private kindergartens in Natal, Northeast Brazil, conducted in 2014-2015. Feeding difficulty was assessed according to Kerzner's criteria, resulting in the profiles "highly selective intake", "active child with small appetite", "fear of feeding", and "child with psychological disorder or neglected". Association with the following independent variables was analyzed by logistic regression: breastfeeding time, age of cows' milk and complementary feeding introduction, age range, family income, type of school, mothers' profile (responsive or nonresponsive), and body mass index (BMI). Feeding difficulty was found in 37.2% of cases, with predominance of "highly selective intake" (25.4%). It was not associated with infancy feeding practices, family income or type of school. There were no differences between the BMI Z score means for the groups with and without feeding difficulty (1.0±1.5 SD and 1.1±1.4 SD, respectively). The five-to-six age range had more occurrences (OR 1.8; 95%CI 1.1-2.9). Children of responsive mothers were less likely to have feeding difficulties (OR 0.4; 95%CI 0.2-0.8). Feeding difficulties were very frequent. Nutritional status was not impacted by it, and infancy eating habits were not associated with it. Responsive mothers' profile is a protective factor against eating difficulties and reinforces the importance of behavioral factors and mother-child interaction.

  12. Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.

    Science.gov (United States)

    Villalba-Galea, Carlos A; Miceli, Francesco; Taglialatela, Maurizio; Bezanilla, Francisco

    2009-07-01

    The Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP) shares high homology with the phosphatidylinositol phosphatase enzyme known as PTEN (phosphatase and tensin homologue deleted on chromosome 10). We have taken advantage of the similarity between these proteins to inquire about the coupling between the voltage sensing and the phosphatase domains in Ci-VSP. Recently, it was shown that four basic residues (R11, K13, R14, and R15) in PTEN are critical for its binding onto the membrane, required for its catalytic activity. Ci-VSP has three of the basic residues of PTEN. Here, we show that when R253 and R254 (which are the homologues of R14 and R15 in PTEN) are mutated to alanines in Ci-VSP, phosphatase activity is disrupted, as revealed by a lack of effect on the ionic currents of KCNQ2/3, where current decrease is a measure of phosphatase activity. The enzymatic activity was not rescued by the introduction of lysines, indicating that the binding is an arginine-specific interaction between the phosphatase binding domain and the membrane, presumably through the phosphate groups of the phospholipids. We also found that the kinetics and steady-state voltage dependence of the S4 segment movement are affected when the arginines are not present, indicating that the interaction of R253 and R254 with the membrane, required for the catalytic action of the phosphatase, restricts the movement of the voltage sensor.

  13. Trudności terapeutyczne u pacjenta z ciężką postacią młodzieńczego zapalenia skórno-mięśniowego powikłanego uogólnioną wapnicą

    Directory of Open Access Journals (Sweden)

    Joanna Szymańska-Kałuża

    2011-08-01

    Full Text Available Młodzieńcze zapalenie skórno-mięśniowe (MZSM to najczęstszaidiopatyczna miopatia zapalna wieku dziecięcego. Do charakterystycznychobjawów tej choroby należą: osłabienie mięśni, głównieobręczy barkowej lub biodrowej, oraz zmiany skórne w postaciobrzęku twarzy, heliotropowego zabarwienia powiek, zmian plamisto-rumieniowych na twarzy i klatce piersiowej. W badaniachlaboratoryjnych typowe dla MZSM są podwyższone wskaźnikiostrej fazy, wysoka aktywność enzymów mięśniowych (aminotransferaz,kinazy kreatynowej oraz dehydrogenazy mleczanowej,a także czasami obecność przeciwciał anty-Jo1. Badanie elektromiograficznewykazuje cechy pierwotnego uszkodzenia mięśni,a w obrazie histopatologicznym wycinka skórno-mięśniowegoodnotowuje się nacieki zapalne. U dzieci często obserwowane sątakże ogniska zwapnień w tkankach miękkich, prowadzące doatrofii mięśni i przykurczów stawowych.Leczeniem I rzutu u pacjentów z MZSM są glikokortykosteroidy,w przypadku nieskuteczności tej terapii stosuje się leki immunosupresyjnelub leki biologiczne, w tym immunoglobuliny.W pracy przedstawiono przypadek pacjenta z ciężkim przebiegiemMZSM powikłanego wapnicą, z uwzględnieniem objawów klinicznychi możliwości leczenia. Omówiono również trudności w doborzenajskuteczniejszej farmakoterapii dla tego pacjenta. U chorego– obecnie 14-letniego chłopca – występowały uogólnione zmianyskórne oraz bardzo gwałtownie narastające liczne złogi soli wapniaw skórze, tkance podskórnej, powięziach i mięśniach, które pojawiły się po 3 latach od wystąpienia pierwszych objawów chorobowych(ryc. 1–8. U chłopca z powodu wybitnie ciężkiego przebieguchoroby prowadzono agresywną konwencjonalną terapię(glikokortykosteroidy, metotreksat, cyklosporyna, pamidronian,która nie przynosiła zadowalających rezultatów i poprawy stanuklinicznego. Na podstawie doniesień z piśmiennictwa światowegopodjęto próbę leczenia

  14. Oops, My Tests Broke the Build : An Explorative Analysis of Travis CI with GitHub

    NARCIS (Netherlands)

    Beller, M.M.; Gousios, Giorgos; Zaidman, A.E.

    2017-01-01

    AbContinuous Integration (CI) has become a best practice of modern software development. Yet, at present, we have a shortfall of insight into the testing practices that are common in CI-based software development. In particular, we
    seek quantifiable evidence on how central testing is to the CI

  15. Is Previous Tubal Ligation a Risk Factor for Hysterectomy because of Abnormal Uterine Bleeding?

    Directory of Open Access Journals (Sweden)

    Sanam Moradan

    2012-07-01

    Full Text Available Objectives: Post tubal ligation syndrome (PTLS is a term used to describe a variety of post tubal ligation side effects or symptoms. These include increased menstrual bleeding and hysterectomy. Whether or not post tubal syndrome is a real entity, it has been a subject of controversy in the medical literature for decades. Numerous studies have reported conflicting conclusions about these symptoms. In this study the incidence of hysterectomy for bleeding disorders among sterilized women was compared with the incidence of hysterectomy for bleeding disorders among non-sterilized female population of the same age.Methods: This study was carried out on 160 women, 38-52 years, who underwent hysterectomy in Amir University Hospital, Semnan, Iran, from September 2008 to September 2011. After gathering of data from medical records, in this study, the incidence of hysterectomy for bleeding disorders among sterilized women was compared with the incidence of hysterectomy for bleeding disorders among nonsterilized female population for the same age.Results: The mean age of the study group was 44/4±5/7 and the mean age of the control group was 45/2±5/3, (p=0.424.The mean parity of the study group was 3/8±1/8 and the mean parity of the control group was 3/5±1/4, (p=0.220. So, in regard to age and parity, two groups were matched. Hysterectomies were performed for 160 cases and abnormal uterine bleeding was the cause of hysterectomy in 67 cases. Among 67 cases, 19 cases (37.3% had previous tubal sterilization + hysterectomy (study group and 48 cases (44% were not undergoing tubal sterilization but had hysterectomy for abnormal bleeding causes (control group. Statistical analyses showed that there were not significant differences between two groups, (RR=0.85; 95% CI: 0.56-1.28; p=0.418.Conclusion: The result of this study showed that previous tubal sterilization is not a risk factor for undergoing hysterectomy because of abnormal uterine bleeding.

  16. Ustawodawstwo Unii Europejskiej wobec mniejszości narodowych i etnicznych - casus romski

    Directory of Open Access Journals (Sweden)

    Wojciech Marcin Stankiewicz

    2014-12-01

    Full Text Available The legislation of the European Union towards national and ethnic minorities - the case of Roma The European Union is still in the stage of creating the system of protection of national and ethnic minorities. Attempts of the European Parliament to improve the situation in the European Union need research and reflection. Social integration is the most important plane guaranteeing European integration, which is the basis for the future functioning of the European Union. The European community, which will be characterized by a common identity, will not be made up of individual countries but nations retaining their own diversity. Despite many efforts of the European Union the situation of the Roma minority has not dramatically improved. The main reasons are insufficient actions by the European Union, corruption of officials, and lack of interest for the Roma community among the Member States. So far, the measures taken have not produced desired results, so it’s necessary to devote more attention to this issue. The European Union needs strong support from other EU institutions and civil society. The main problem that affects the Roma community is long and difficult road to integration and acceptance by the other citizens of the European Union. A common phenomenon is the reluctance to strangers who are victims of discrimination. Strongly rooted stereotypes, lack of tolerance for other cultures proves that even the best-designed programs, as well as initiatives from the European Union are not sufficient. First of all, there is a need for commitment and unforced intercultural education from both the Roma and the rest of society, which will lead to mutual respect for differences. The phenomenon of social exclusion of the Roma minority is often related to their lifestyle, habits and patterns different from the rest of the society. Help which is offered by the European Union and the Member States is generally perceived as an attempt to breach the culture

  17. Ocena sprawności funkcjonalnej chorych na reumatoidalne zapalenie stawów na podstawie funkcjonalnego testu z wystandaryzowanym wyposażeniem

    Directory of Open Access Journals (Sweden)

    Grażyna Bączyk

    2011-02-01

    Full Text Available Reumatoidalne zapalenie stawów (RZS jest przewlekle postępującymprocesem zapalnym błony maziowej, doprowadzającym doniszczenia tkanek stawowych i okołostawowych, w wyniku czegodochodzi do zniekształceń i upośledzenia funkcji stawów, co w konsekwencjiprowadzi do trwałego kalectwa. Celem badań była ocenasprawności funkcjonalnej chorych na RZS. Materiały i metody: Grupę badaną stanowiło 120 chorych na reumatoidalnezapalenie stawów leczonych w poradni reumatologicznejw Poznaniu. Kobiety stanowiły 75% badanych. Średnia wiekubadanych to 52,15 roku (SD 12,73. Średni czas trwania chorobywynosił 13,47 roku, (SD 8,62 (tab. I.Objawy ze strony układu kostno-stawowego oceniano wg następującychzasad: czas trwania sztywności porannej, natężenie bólu wgskali VAS, bolesność uciskowa stawów z wykorzystaniem RitchieArticular Index, siła mięśniowa ręki na podstawie siły chwytu. Dooceny sprawności funkcjonalnej chorych wykorzystano funkcjonalnytest z wystandaryzowanym wyposażeniem (tab. II. Wyniki: Około 60% kobiet i 40% mężczyzn nie było zdolnych dowykonania takiego zadania, jak otwieranie słoika. Wykonanie większościzadań wymagało od badanych zastosowania pewnego rodzajupomocy technicznej albo wykonanie danej czynności odbywało siępowoli czy też z pomocą drugiej osoby (tab. III. Wnioski: Złe wyniki oceny funkcjonowania chorych na reumatoidalnezapalenie stawów, niezależnie od płci, świadczą o ograniczeniumożliwości wykonywania podstawowych aktywności życiowych.Wiązało się to z bólem stawów, czasem trwania objawu sztywnościporannej oraz słabą siłą mięśniową rąk.

  18. Digital Breast Tomosynthesis with Synthesized Two-Dimensional Images versus Full-Field Digital Mammography for Population Screening: Outcomes from the Verona Screening Program.

    Science.gov (United States)

    Caumo, Francesca; Zorzi, Manuel; Brunelli, Silvia; Romanucci, Giovanna; Rella, Rossella; Cugola, Loredana; Bricolo, Paola; Fedato, Chiara; Montemezzi, Stefania; Houssami, Nehmat

    2018-04-01

    Purpose To examine the outcomes of a breast cancer screening program based on digital breast tomosynthesis (DBT) plus synthesized two-dimensional (2D) mammography compared with those after full-field digital mammography (FFDM). Materials and Methods This prospective study included 16 666 asymptomatic women aged 50-69 years who were recruited in April 2015 through March 2016 for DBT plus synthetic 2D screening in the Verona screening program. A comparison cohort of women screened with FFDM (n = 14 423) in the previous year was included. Screening detection measures for the two groups were compared by calculating the proportions associated with each outcome, and the relative rates (RRs) were estimated with multivariate logistic regression. Results Cancer detection rate (CDR) for DBT plus synthetic 2D imaging was 9.30 per 1000 screening examinations versus 5.41 per 1000 screening examinations with FFDM (RR, 1.72; 95% confidence interval [CI]: 1.30, 2.29). CDR was significantly higher in patients screened with DBT plus synthetic 2D imaging than in those screened with FFDM among women classified as having low breast density (RR, 1.53; 95% CI: 1.13, 2.10) or high breast density (RR, 2.86; 95% CI: 1.42, 6.25). The positive predictive value (PPV) for recall was almost doubled with DBT plus synthetic 2D imaging: 23.3% versus 12.9% of recalled patients who were screened with FFDM (RR, 1.81; 95% CI: 1.34, 2.47). The recall rate was similar between groups (RR, 0.95; 95% CI: 0.84, 1.06), whereas the recall rate with invasive assessment was higher for DBT plus synthetic 2D imaging than for FFDM (RR, 1.93; 95% CI: 1.31, 2.03). The mean number of screening studies interpreted per hour was significantly lower for screening examinations performed with DBT plus synthetic 2D imaging (38.5 screens per hour) than with FFDM (60 screens per hour) (P < .001). Conclusion DBT plus synthetic 2D imaging increases CDRs with recall rates comparable to those of FFDM. DBT plus synthetic 2D imaging

  19. “Resistir e Consolidar”: história e trajetória do Centro Acadêmico de Ciências do Estado CACE

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    João Lucas Ribeiro Moreira

    2016-07-01

    Full Text Available RESUMO: O presente artigo se propõe a fazer uma análise histórica da recente, porém intensa trajetória do Centro Acadêmico do curso de Ciências do Estado (CACE da Universidade Federal de Minas Gerais. Desse modo, nos propomos a uma recuperação do processo de constituição do Centro Acadêmico, bem como uma análise sistemática das gestões que atuaram no CACE desde sua fundação até o ano de 2015, sendo elas: “SuperAção”, “Movimenta”, “Praxis”, “Construção Coletiva”, “COR”, além das perspectivas para a atual gestão do CACE, a “Ubuntu”. Desse modo, o artigo revela o estreito limiar existente entre a atuação estudantil organizada na consolidação e resistência do curso de Ciências do Estado da UFMG. PALAVRAS-CHAVE: Ciências do Estado; Centro Acadêmico; Movimento Estudantil.

  20. The Relationship Between Functional Movement, Balance Deficits, and Previous Injury History in Deploying Marine Warfighters.

    Science.gov (United States)

    de la Motte, Sarah J; Lisman, Peter; Sabatino, Marc; Beutler, Anthony I; OʼConnor, Francis G; Deuster, Patricia A

    2016-06-01

    Screening for primary musculoskeletal injury (MSK-I) is costly and time-consuming. Both the Functional Movement Screen (FMS) and the Y-Balance Test (YBT) have been shown to predict future MSK-I. With a goal of optimizing the efficiency of primary MSK-I screening, we studied associations between performance on the FMS and YBT and whether history of MSK-I influenced FMS and YBT scores. In total, 365 deploying Marines performed the FMS and YBT as prescribed. Composite and individual scores were each categorized as high risk or low risk using published injury thresholds: High-risk FMS included composite scores ≤14 and right-to-left (R/L) asymmetry for Shoulder Mobility, In-Line Lunge, Straight Leg Raise, Hurdle Step, or Rotary Stability. High-risk YBT consisted of anterior, posteromedial, and/or posterolateral R/L differences >4 cm and/or composite differences ≥12 cm. Pearson's χ tests evaluated associations between: (a) all FMS and YBT risk groups and (b) previous MSK-I and all FMS and YBT risk groups. Marines with high-risk FMS were twice as likely to have high-risk YBT posteromedial scores (χ = 10.2, p = 0.001; odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.3-3.2). History of any MSK-I was not associated with high-risk FMS or high-risk YBT. However, previous lower extremity MSK-I was associated with In-Line Lunge asymmetries (χ = 9.8, p = 0.002, OR = 2.2, 95% CI = 1.3-3.6). Overall, we found limited overlap in FMS and YBT risk. Because both methods seem to assess different risk factors for injury, we recommend FMS and YBT continue to be used together in combination with a thorough injury history until their predictive capacities are further established.

  1. WERYFIKACJA MOŻLIWOŚCI ZASTOSOWANIA WSKAŹNIKA ITS DO OCENY STANU TROFICZNEGO ZBIORNIKA DOBCZYCKIEGO

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    Elena NEVEROVA-DZIOPAK

    2016-05-01

    Full Text Available W ostatnich latach problem eutrofizacji stał się powszechny nie tylko w wodach stojących ale także w płynących. Budzi on spore zainteresowanie zwłaszcza gdy zaczyna dotyczyć wód przeznaczonych do zaopatrzenia ludzi w wodę do spożycia. Zbiornik Dobczycki o którym traktuje artykuł jest właśnie takim rezerwuarem. Tu ujmowana jest woda dla mieszkańców Krakowa. W literaturze spotyka się stwierdzenia, że wody zbiornika zawsze były podatne na eutrofizację ze względu na ładunki biogenów które są wnoszone do niego przez Rabę. Problem oceny stopnia eutrofizacji Zbiornika Dobczyckiego został więc podjęty nie tyle ze względów poznawczych, co utylitarnych. Wymagał rzetelnej i szczegółowej analizy danych pomiarowych pochodzących z monitoringu. Do oceny zjawiska eutrofizacji wykorzystano integralny wskaźnik troficzności ITS. Jest on jednym z coraz powszechniej stosowanych obecnie zagregowanych wskaźników. Dostrzeżono że graniczne wartości pojedynczych parametrów niekoniecznie odzwierciedlają stan trofii i uprawniają do wnioskowania o zjawisku eutrofizacji. Zastosowanie wskaźnika ITS wiąże się z wykorzystaniem parametrów takich jak pH i nasycenie wody tlenem, które odzwierciedlają bilans gazowy w wodach, zmieniający się wraz ze zmianą bilansu procesów produkcji i rozkładu materii organicznej. Nie wymaga on więc szczegółowych oznaczeń monitoringowych, przez co może być wykorzystywany jako uniwersalny sposób oceny trofii. W artykule uzasadniono wybór wskaźnika ITS jako metody oceny trofii na podstawie analizy statystycznej danych monitoringu Zbiornika pochodzących z okresu wieloletniego. Uwiarygodniło to ocenę i pozwoliło dostrzec pewne prawidłowości procesu oraz jego dynamikę. Na jej podstawie możliwa jest prognoza prawdopodobnego scenariusza dalszego rozwoju zjawiska. Utrzymujący się w minionych 15 latach stan pograniczny zaawansowanej mezotrofii/eutrofii przy jednoczesnej dobrej

  2. Wpływ głęboszowania na zmiany właściwości fizyko-wodnych gleby płowej

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    Andrzej Bogdał

    2014-12-01

    Full Text Available Badania wpływu głęboszowania na właściwości fizyko-wodne zbitych gleb uprawnych wykonano na gruntach ornych w miejscowości Wojnowice, położonej na terenie powiatu raciborskiego w województwie śląskim. Podczas prac terenowych wykonano i opisano po jednej odkrywce glebowej na polu głęboszowanym i niegłęboszowanym. Z każdego poziomu genetycznego obu profili glebowych pobrano próby gleby o strukturze nienaruszonej i naruszonej. Przy obu odkrywkach w warstwie ornej i podornej pomierzono przepuszczalność gleby. W laboratorium oznaczono skład granulometryczny, wilgotność, zawartość próchnicy i charakterystyczne gęstości gleby oraz wyliczono porowatość ogólną. Analiza wyników badań wykazała, że głębokie spulchnianie gleb płowych powoduje zmniejszenie ich gęstości objętościowej oraz zwiększenie infiltracji i porowatości ogólnej. Stwierdzono również poprawę stosunków powietrzno-wodnych w profilu głęboszowanym – zwiększyła się tam zawartość powietrza glebowego, a zmniejszyło uwilgotnienie. Badania wykazały, że nawet po 20 miesiącach od wykonania zabiegów agromelioracyjnych ich wpływ na wykorzystanie potencjalnych zdolności retencyjnych gleby jest zauważalny, co w konsekwencji może prowadzić do łagodzenia skutków zjawisk ekstremalnych –susz i powodzi.

  3. Dylematy etyczno‑prawne związane z hospitalizacją psychiatryczną kobiety w ciąży

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    Błażej Kmieciak

    2011-12-01

    Full Text Available Przeprowadzone w ciągu ostatnich kilku lat badania społeczne dowodzą, że coraz więcej Polaków korzysta z pomocy psy‑ chiatrycznej opieki zdrowotnej. Do szpitali psychiatrycznych zgłasza się także coraz więcej pacjentek w ciąży. Nie tylko leczenie, ale cały proces hospitalizacji pacjentki w ciąży stanowi niezwykłe wyzwanie dla personelu lekarsko‑pielęgniar‑ skiego. Psychiatryczna hospitalizacja pacjentki spodziewającej się potomstwa w sposób szczególny musi uwzględniać fundamentalną w polskiej psychiatrii zasadę najmniejszej uciążliwości. Poniższy artykuł ma na celu ukazanie kilku dyle‑ matów, jakie wiążą się z leczeniem i opieką nad tą grupą pacjentek. Przedstawione zostaną przykłady związane z przy‑ musową hospitalizacją, stosowaniem przymusu bezpośredniego oraz stosowaniem zabiegów elektrowstrzasów wobec pacjentek spodziewających się dziecka, a także zasady, jakich należy przestrzegać w trakcie wykonywania wspomnia‑ nych działań. Omówione zostanie również szczególnie delikatne zagadnienie dotyczące tzw. psychiatrycznych przesła‑ nek uprawniających do wykonania aborcji. Zagadnienie to, komentowane głównie poza granicami naszego kraju, powin‑ no być przeanalizowane także z perspektywy polskich przepisów prawa. Dlatego też w odniesieniu do proponowanego tematu, bazując na konkretnym kazusie, z jednej strony zostaną przedstawione informacje dotyczące polskich oraz za‑ granicznych podstaw prawnych uprawniających do dokonania aborcji, z drugiej – wyniki badań ukazujących wyraźnie niebezpieczeństwo legalizacji wspomnianych praktyk, co istotne – niebezpieczeństwo odnoszące się bezpośrednio do po‑ gorszenia się stanu zdrowia psychicznego pacjentki poddającej się zabiegowi przerwania ciąży.

  4. Wybrane zagadnienia dotyczące pomiaru, wyceny,ewidencji i ujęcia w sprawozdawczości kapitału intelektualnego. Artykuł polemiczny  

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    Ewa Chojnacka

    2015-09-01

    Full Text Available Celem niniejszego artykułu jest odniesienie wybranych propozycji, zawartych w publikacji Lesława Niemczyka Rachunkowość finansowa aktywów kompetencyjnych i kapitału intelektualnego. Nowy dział rachunkowości, do istniejących w literaturze przedmiotu koncepcji. W opracowaniu omówiono zagadnienie wartości przedsiębiorstwa, przedstawiono wybrane definicje kapitału intelektualnego oraz wybrane koncepcje metod jego pomiaru i wyceny. Odniesiono się do zagadnień związanych z ewidencją i sprawozdawczością dotyczącą kapitału intelektualnego w księgach organizacji. W publikacji dokonano ponadto analizy podobieństw i różnic poruszanych zagadnień w odniesieniu do krajowej i zagranicznej literatury przedmiotu, a także istniejących regulacji prawnych i standardów.

  5. Korzyści z podejmowania regularnej aktywności fizycznej przez osoby starsze = The benefits of regular physical activity for the elderly

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    U. Kaźmierczak

    2015-01-01

    3Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy   Słowa kluczowe: regularna aktywność fizyczna, osoby starsze.   Keywords: regular physical activity, elderly.   Abstrakt W państwach rozwiniętych i rozwijających się coraz większą grupę społeczeństw stanowią seniorzy. Świadomość problemu spowodowała podjęcie powszechnej dyskusji ekspertów i praktyków z dziedzin medycznych na temat konieczności działań niezbędnych dla zapewnienia społeczeństwom pomyślnej starości. Od dawna wskazuje się, że brak aktywności ruchowej jest dla zdrowia niebezpieczny. Starzeniu się układu sercowo-naczyniowego towarzyszy dużo niekorzystnych zmian strukturalnych, czynnościowych i biochemicznych. Za typowe dla tego okresu zmiany uważa się osłabienie możliwości relaksacji włókien mięśniowych, co może być przyczyną rozkurczowej niewydolności serca. Trening zdrowotny – jest rodzajem aktywności fizycznej wykonywanej z powodów medycznych. Celem jest uzyskanie efektów fizycznych oraz psychicznych przeciwdziałających zmniejszaniu się zdolności adaptacyjnych organizmu. Eksperci przekonują osoby starsze o korzyściach płynących z aktywnego fizycznie stylu życia. Bogate piśmiennictwo poruszające tematykę medycznych aspektów procesu starzenia, mówi o niezaprzeczalnym znaczeniu ruchu dla toczących się w ludzkim ciele procesów inwolucyjnych. Aktywność fizyczna odpowiednio dozowana jest w stanie wyraźnie zmniejszyć negatywny wpływ tych zmian i jak najdłużej pozwolić utrzymać zdrowie fizyczne, psychiczne i społeczne. Zauważono, że systematycznie dozowany wysiłek fizyczny zmniejsza ryzyko wystąpienia wielu chorób np. cukrzycy, miażdżycy, choroby niedokrwiennej serca. Liczne badania naukowe i bogate piśmiennictwo gerontologiczne przedstawiają najnowsze doniesienia specjalistów o tym, jak należy prawidłowo przygotować i prowadzić trening fizyczny z osobami starszymi

  6. Educação inclusiva, ensino de Ciências e linguagem científica: possíveis relações

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    Anna Maria Canavarro Benite

    2015-01-01

    Full Text Available Atualmente, reclama-se por uma Educação Inclusiva na Sociedade da Informação. Dessa forma, é urgente se ensinar ciências no mundo onde o saber científico e tecnológico é cada dia mais valorizado, admitindo que não é possível a formação de um cidadão crítico sem conhecimentos básicos necessários para a realização de julgamentos e consequentes opções. O exercício da cidadania exige a participação efetiva dos indivíduos, tenham eles necessidades educativas especiais (NEE ou não, em todas as esferas da sociedade. Neste artigo, serão apresentados alguns apontamentos sobre a relação complexa entre educação inclusiva, ensino de ciências e linguagem científica, assumindo a urgência da compreensão de necessidades específicas que possam orientar o ensino de ciências para este grupo social. Completa este trabalho uma breve discussão sobre as características do conhecimento científico.

  7. Association of previous severe low birth weight with adverse perinatal outcomes in a subsequent pregnancy among HIV-prevalent urban African women.

    Science.gov (United States)

    Smid, Marcela C; Ahmed, Yusuf; Stoner, Marie C D; Vwalika, Bellington; Stringer, Elizabeth M; Stringer, Jeffrey S A

    2017-02-01

    To evaluate the association between severity of prior low birth weight (LBW) delivery and adverse perinatal outcomes in the subsequent delivery among an HIV-prevalent urban African population. A retrospective cohort study was conducted among 41 109 women who had undergone two deliveries in Lusaka, Zambia, between February 1, 2006, and May 31, 2013. The relationship between prior LBW delivery (<2500 g) and a composite measure of adverse perinatal outcome in the second pregnancy was assessed using multivariate logistic regression. Women with prior LBW delivery (n=4259) had an increased risk of LBW in the second delivery versus those without prior LBW delivery (n=37 642). Such risk correlated with the severity of first delivery LBW. The adjusted odds ratio (AOR) was 2.89 (95% confidence interval [CI] 2.05-4.09) for a birth weight of 1000-1499 g, 3.05 (95% CI 2.42-3.86) for a birth weight of 1500-1999 g, and 2.02 (95% CI 1.81-2.27) for a birth weight of 2000-2499 g. Previous LBW delivery also increased the risk of adverse perinatal outcome, with an AOR of 1.4 (95% CI 1.2-1.7). Severe prior LBW delivery conferred substantial risk for adverse perinatal outcomes in a subsequent pregnancy. © 2016 International Federation of Gynecology and Obstetrics.

  8. Natureza em Pauta: reflexões sobre a divulgação ambiental na ciência hoje

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    BRANDÃO, Alessandra Gomes

    2009-06-01

    Full Text Available This article is a result of a research that examined material on environment published in the magazine Ciência Hoje, with the objective of investigating how the ambient questions presents for the Brazilian society, by a periodic. The analysis of the divulgation of the contents about the environment was carried through, identificating as the terms Environment and Nature appear in the texts; if both the chains of thoughts in defense of the nature (biocentric and anthropocentric appear in publications, and still as the concept of sustainable development is presented by the authors of publications.

  9. Previous injuries and some training characteristics predict running-related injuries in recreational runners: a prospective cohort study.

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    Hespanhol Junior, Luiz Carlos; Pena Costa, Leonardo Oliveira; Lopes, Alexandre Dias

    2013-12-01

    What is the incidence of running-related injuries (RRIs) in recreational runners? Which personal and training characteristics predict RRIs in recreational runners? Prospective cohort study. A total of 200 recreational runners answered a fortnightly online survey containing questions about their running routine, races, and presence of RRI. These runners were followed-up for a period of 12 weeks. The primary outcome of this study was running-related injury. The incidence of injuries was calculated taking into account the exposure to running and was expressed by RRI/1000 hours. The association between potential predictive factors and RRIs was estimated using generalised estimating equation models. A total of 84 RRIs were registered in 60 (31%) of the 191 recreational runners who completed all follow-up surveys. Of the injured runners 30% (n=18/60) developed two or more RRIs, with 5/18 (28%) being recurrences. The incidence of RRI was 10 RRI/1000 hours of running exposure. The main type of RRI observed was muscle injuries (30%, n=25/84). The knee was the most commonly affected anatomical region (19%, n=16/84). The variables associated with RRI were: previous RRI (OR 1.88, 95% CI 1.01 to 3.51), duration of training although the effect was very small (OR 1.01, 95% CI 1.00 to 1.02), speed training (OR 1.46, 95% CI 1.02 to 2.10), and interval training (OR 0.61, 95% CI 0.43 to 0.88). Physiotherapists should be aware and advise runners that past RRI and speed training are associated with increased risk of further RRI, while interval training is associated with lower risk, although these associations may not be causative. Copyright © 2013 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

  10. Teorias de aprendizagem e o ensino/aprendizagem das ciências: da instrução à aprendizagem

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    Clara Vasconcelos

    Full Text Available Uma preocupação sempre presente da investigação na área da Psicologia Educacional, é a da compreensão do processo de aprendizagem do aluno, nomeadamente em contexto formal de ensino. Nessa linha, o ensino das ciências recorre a essa área de conhecimento para fundamentar teoricamente concepções e práticas de ensino/aprendizagem, no contexto e ecologia de sala de aula específicos. Neste artigo apresenta-se o contributo das diversas teorias de aprendizagem no processo de ensino/aprendizagem das ciências, especificando a influência de algumas delas nas perspectivas de ensino que foram sendo evolutivamente assumidas. Desse modo, inicia-se uma descrição histórica, referindo perspectivas de ensino apoiadas na vertente behaviorista e termina-se a sua abordagem referindo teorias cognitivo-construtivistas, que deram lugar a perspectivas de ensino voltadas para o papel do aluno, como sujeito ativo na construção do conhecimento, e para o reconhecimento do valor meramente instrumental dos conteúdos curriculares.

  11. Test Characteristics of Neck Fullness and Witnessed Neck Pulsations in the Diagnosis of Typical AV Nodal Reentrant Tachycardia

    Science.gov (United States)

    Sakhuja, Rahul; Smith, Lisa M; Tseng, Zian H; Badhwar, Nitish; Lee, Byron K; Lee, Randall J; Scheinman, Melvin M; Olgin, Jeffrey E; Marcus, Gregory M

    2011-01-01

    Summary Background Claims in the medical literature suggest that neck fullness and witnessed neck pulsations are useful in the diagnosis of typical AV nodal reentrant tachycardia (AVNRT). Hypothesis Neck fullness and witnessed neck pulsations have a high positive predictive value in the diagnosis of typical AVNRT. Methods We performed a cross sectional study of consecutive patients with palpitations presenting to a single electrophysiology (EP) laboratory over a 1 year period. Each patient underwent a standard questionnaire regarding neck fullness and/or witnessed neck pulsations during their palpitations. The reference standard for diagnosis was determined by electrocardiogram and invasive EP studies. Results Comparing typical AVNRT to atrial fibrillation (AF) or atrial flutter (AFL) patients, the proportions with neck fullness and witnessed neck pulsations did not significantly differ: in the best case scenario (using the upper end of the 95% confidence interval [CI]), none of the positive or negative predictive values exceeded 79%. After restricting the population to those with supraventricular tachycardia other than AF or AFL (SVT), neck fullness again exhibited poor test characteristics; however, witnessed neck pulsations exhibited a specificity of 97% (95% CI 90–100%) and a positive predictive value of 83% (95% CI 52–98%). After adjustment for potential confounders, SVT patients with witnessed neck pulsations had a 7 fold greater odds of having typical AVNRT, p=0.029. Conclusions Although neither neck fullness nor witnessed neck pulsations are useful in distinguishing typical AVNRT from AF or AFL, witnessed neck pulsations are specific for the presence of typical AVNRT among those with SVT. PMID:19479968

  12. Kształtowanie polskości na łamach „Dziennika Kijowskiego” w latach 1914-1916

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    Olena Betlii

    2017-12-01

    Full Text Available The Shaping of Polish Identity in the “Dziennik Kijowski” in 1914-1916 The First World War was a real catalyst for the shaping of national identities in Eastern Europe. Like all wars, it aroused discussions about the future of peoples caught up in the conflict, especially those who did not possess their own statehood. The Polish nation was among them. How did its political elite respond to the beginning of the Great War in Europe, what was discussed and what topics raised by the Polish newspapers, how Poland’s future and Polish identity was seen and determined at that time? In this article I try to answer these questions by analyzing political, social and literary materials in the Polish daily Dziennik Kijowski published in Kyiv in 1906-1920. Based on archival sources, publications of the Dziennik, analysis of the censuses, and historiography, this publication depicts the “Polish Kyiv”, reflects on various opinions about the newspaper’s editorial policies during the war, and defines the main topics that were elaborated by the Dziennik in 1914-1916 regarding Polish identity issues. During this period the newspaper, as well as the majority of members of the Polish community in Kyiv, was loyal to the Russian authorities. At the same time, the Dziennik Kijowski constantly reminded its readers what the Polish identity meant not only by the mere fact that the newspaper was published in the Pollish language, but also by the Polish matters as the contents of its columns.   Kształtowanie polskości na łamach „Dziennika Kijowskiego” w latach 1914-1916 Pierwsza wojna światowa stała się prawdziwym katalizatorem kształtowania tożsamości narodowych w Europie Wschodniej. Jak każda inna wojna wywoływała ona dyskusje o przyszłości narodów wciągniętych w konflikt, zwłaszcza tych, które nie posiadały swojej państwowości. Do takich narodów wówczas należał również naród polski. W jaki sposób polskie elity polityczne

  13. Amor e ciúme na contemporaneidade: reflexões psicossociológicas Love and jealousy in the contemporary world: psychosociological reflections

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    Lauane Baroncelli

    2011-04-01

    Full Text Available O presente artigo deriva-se da dissertação de Mestrado da autora que trata do ciúme nas relações amorosas contemporâneas. Partindo da perspectiva de que o ciúme na experiência amorosa é uma condição historicamente constituída, procuramos, neste estudo, investigar teoricamente as consequências que as práticas e princípios culturalmente estabelecidos na contemporaneidade têm sobre a experiência de ciúme dos indivíduos contemporâneos. Na busca desse objetivo, nosso estudo, a seguir, busca refletir sobre alguns impactos que o momento histórico atual tem produzido no domínio do amor, para, finalmente, discutir algumas maneiras de compreender o ciúme que se revela numa experiência amorosa que, nos dias de hoje, se vê marcada por intensa transitoriedade, flexibilidade e abertura.This work derives from the author's master thesis which focused jealousy in nowadays love relationships. Starting from the idea that the jealousy in love experience is a historically built condition, we search, in this study, for the consequences that different practices and principles established in contemporary culture to which individuals are exposed, have on their jealousy experience. Looking towards this objective, the present article tries to understand the peculiarities found in today's loving experience and the consequences that these peculiarities have in jealousy in love relationships which are, nowadays, characterized by an intense flexibility, transitiveness and openness.

  14. Women in the United States Marine Corps CI/HUMINT Community

    National Research Council Canada - National Science Library

    Reese, Jackson L

    2008-01-01

    The purpose of the researchers Masters of Military Arts and Science thesis is to explore the possibility of including women in the Marine Corps CI/HUMINT community without diminishing the overall unit...

  15. I-Xe dating of aqueous alteration in the CI chondrite Orgueil: I. Magnetite and ferromagnetic separates

    Science.gov (United States)

    Pravdivtseva, O.; Krot, A. N.; Hohenberg, C. M.

    2018-04-01

    The I-Xe system was studied in a ferromagnetic sample separated from the Orgueil CI carbonaceous chondrite with a hand-held magnet and in two magnetite samples, one chemically separated before and the other one after neutron irradiation. This work was done in order to investigate the effects of chemical separation by LiCl and NaOH on the I-Xe system in magnetite. Our test demonstrated that the chemical separation of magnetite before irradiation using either LiCl or NaOH, or both, does not contaminate the sample with iodine and thus cannot lead to erroneous I-Xe ages due to introduction of uncorrelated 128∗Xe. The I-Xe ages of two Orgueil magnetite samples are mutually consistent within experimental uncertainties and, when normalized to an absolute time scale with the reevaluated Shallowater aubrite standard, place the onset of aqueous alteration on the CI parent body at 4564.3 ± 0.3 Ma, 2.9 ± 0.3 Ma after formation of the CV Ca-AI-rich inclusions (CAIs). The I-Xe age of the ferromagnetic Orgueil separate is 3.4 Ma younger, corresponding to a closure of the I-Xe system at 4560.9 ± 0.2 Ma. These and previously published I-Xe data for Orgueil (Hohenberg et al., 2000) indicate that aqueous alteration on the CI parent body lasted for at least 5 Ma. Although the two magnetite samples gave indistinguishable I-Xe ages, their temperature release profiles differed. One of the two Orgueil magnetites released less radiogenic Xe than the other, 80% of it corresponding to the low-temperature peak of the release profile, compared to only 6% in case of the second Orgueil magnetite sample. This could be due to the difference in iodine trapping efficiencies for magnetite grains of different morphologies. Alternatively, the magnetite grains with the lower radiogenic Xe concentrations may have formed at a later stage of alteration when iodine in an aqueous solution was depleted.

  16. Biografia nieobecna. Wokół życia i twórczości Ireneusza Plater-Zyberka

    Directory of Open Access Journals (Sweden)

    Robert Zawisza

    2014-12-01

    Full Text Available An Absent Biography. About the life and work of Ireneusz Plater-Zyberk Ireneusz Plater-Zyberk (1896–1946, was a writer and a film producer, adventurer and gallant. His life is an incredible story of the disabled individual who succeeded in an amazing career. Plater-Zyberk was born in a wealthy landowning family who lived at the estate of Vabole in Latvia. He was born without hands and at that time, due to his disability, was classified as "margins of society." Thanks to perseverance and commitment of his mother, he graduated as an extern student from high school in Warsaw, Poland. His career  includes Life without Hands, memories,  and two novels. He was a co-author of first movie in Poland with stunt effects Dead Node (1927, which unfortunately wasn’t preserved. Also, he was recognized as a documentary creator as well as an initiator of film production regulations.   Biografia nieobecna. Wokół życia i twórczości Ireneusza Plater-Zyberka Ireneusz Plater-Zyberk (1896 lub 1897–1946 był literatem i twórcą filmowym, nieco awanturnikiem i bawidamkiem. Jego postać to niezwykły przykład niepełnosprawnego, który osiągnął w dwudziestoleciu międzywojennym znaczącą karierę. Ireneusz Plater-Zyberk pochodził z zamożnej rodziny ziemiańskiej, zamieszkałej w majątku Wabol na Łotwie. Urodził się bez rąk i w ówczesnej rzeczywistości miał pozostać na marginesie społeczeństwa. Dzięki wytrwałości matki udało mu się ukończyć jako ekstern gimnazjum w Warszawie. W swoim dorobku ma wspomnienia Życie bez rąk oraz dwie powieści. Ważną rolę odegrał Plater jako scenarzysta i reżyser, był m.in. współtwórcą pierwszego polskiego filmu z efektami kaskaderskimi „Martwy węzeł” (1927. Miał on również ogromne zasługi jako twórca filmów dokumentalnych i jednocześnie inspirator zmian w prawodawstwie dotyczącym produkcji filmowej. Tłem jego twórczości pisarskiej jest burzliwe i pełne przygód

  17. Photocatalytic Membrane Reactor for the Removal of C.I. Disperse Red 73

    Directory of Open Access Journals (Sweden)

    Valentina Buscio

    2015-06-01

    Full Text Available After the dyeing process, part of the dyes used to color textile materials are not fixed into the substrate and are discharged into wastewater as residual dyes. In this study, a heterogeneous photocatalytic process combined with microfiltration has been investigated for the removal of C.I. Disperse Red 73 from synthetic textile effluents. The titanium dioxide (TiO2 Aeroxide P25 was selected as photocatalyst. The photocatalytic treatment achieved between 60% and 90% of dye degradation and up to 98% chemical oxygen demand (COD removal. The influence of different parameters on photocatalytic degradation was studied: pH, initial photocatalyst loading, and dye concentration. The best conditions for dye degradation were pH 4, an initial dye concentration of 50 mg·L−1, and a TiO2 loading of 2 g·L−1. The photocatalytic membrane treatment provided a high quality permeate, which can be reused.

  18. AHRQ series on complex intervention systematic reviews-paper 7: PRISMA-CI elaboration and explanation.

    Science.gov (United States)

    Guise, Jeanne-Marie; Butler, Mary; Chang, Christine; Viswanathan, Meera; Pigott, Terri; Tugwell, Peter

    2017-10-01

    Complex interventions are widely used in health care, public health, education, criminology, social work, business, and welfare. They have increasingly become the subject of systematic reviews and are challenging to effectively report. The Complex Interventions Methods Workgroup developed an extension to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Complex Interventions (PRISMA-CI). Following the EQUATOR Network guidance for Preferred Reporting Items for Systematic Reviews and Meta-Analysis extensions, this Explanation and Elaboration (EE) document accompanies the PRISMA-CI checklist to promote consistency in reporting of systematic reviews of complex interventions. The EE document explains the meaning and rationale for each unique PRISMA-CI checklist item and provides examples to assist systematic review authors in operationalizing PRISMA-CI guidance. The Complex Interventions Workgroup developed PRISMA-CI as an important start toward increased consistency in reporting of systematic reviews of complex interventions. Because the field is rapidly expanding, the Complex Interventions Methods Workgroup plans to re-evaluate periodically for the need to add increasing specificity and examples as the field matures. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Muzealizacja przestrzeni publicznej jako forma obecności dziedzictwa kulturowego we współczesnym społeczeństwie

    Directory of Open Access Journals (Sweden)

    Andrzej Kadłuczka

    2018-04-01

    Full Text Available W artykule omówiono nowe zjawisko muzealizacji przestrzeni publicznej, które nie oznacza jedynie dostrzeganego przez socjologów dynamicznie wzrastającego zapotrzebowania społecznego na innowacyjnie i atrakcyjnie kształtowane muzea, czy centra promocji dziedzictwa historycznego, ale także coraz szersza, bezpośrednią – „fizyczną” obecność tego dziedzictwa w życiu współczesnego człowieka. Jest ta obecność generowana poprzez inwestycje realizowane na terenach historycznych, które stają się źródłem coraz większej ilości struktur i artefaktów pochodzących z przeszłości „zasiedlających” przestrzeń publiczną w formie niej lub bardziej udanych ekspozycji rekonstruujących rzeczywistość historyczną.

  20. Analyzing nitrogen concentration using carrier illumination (CI) technology for DPN ultra-thin gate oxide

    International Nuclear Information System (INIS)

    Li, W.S.; Wu, Bill; Fan, Aki; Kuo, C.W.; Segovia, M.; Kek, H.A.

    2005-01-01

    Nitrogen concentration in the gate oxide plays a key role for 90 nm and below ULSI technology. Techniques like secondary ionization mass spectroscopy (SIMS) and X-ray photoelectron spectroscopy (XPS) are commonly used for understanding N concentration. This paper describes the application of the carrier illuminationTM (CI) technique to measure the nitrogen concentration in ultra-thin gate oxides. A set of ultra-thin gate oxide wafers with different DPN (decoupled plasma nitridation) treatment conditions were measured using the CI technique. The CI signal has excellent correlation with the N concentration as measured by XPS

  1. Functional social support, psychological capital, and depressive and anxiety symptoms among people living with HIV/AIDS employed full-time.

    Science.gov (United States)

    Liu, Li; Pang, Ran; Sun, Wei; Wu, Ming; Qu, Peng; Lu, Chunming; Wang, Lie

    2013-12-01

    Psychological distress (e.g., depression and anxiety) has been regarded as the main cause of leaving work for people living with HIV/AIDS (PLWHA) in workplaces. This study aims to explore the associations of functional social support (FSS) and psychological capital (PC) with depressive and anxiety symptoms among PLWHA employed full-time. This cross-sectional study was performed in Liaoning, China, during the period of December 2010-April 2011. The Center for Epidemiologic Studies Depression Scale, the Zung Self-Rating Anxiety Scale, the Duke-UNC Functional Social Support Questionnaire, and the Psychological Capital Questionnaire were completed by PLWHA employed full-time. Structural equation modeling was used to test the proposed relationships between variables. Asymptotic and resampling strategies were performed to explore the mediating roles of PC and its components (self-efficacy, hope, optimism, resilience). Of 320 participants surveyed, 66.3% had depressive symptoms, and 45.6% had anxiety symptoms. Significant negative associations of FSS and PC with depressive and anxiety symptoms were revealed. PC (a*b = -0.209, BCa 95% CI: -0.293, -0.137, p < 0.05), hope (a*b = -0.103, BCa 95% CI: -0.192, -0.034, p < 0.05), and optimism (a*b = -0.047, BCa 95% CI: -0.106, -0.008, p < 0.05) significantly mediated the association between FSS and depressive symptoms. PC (a*b = -0.151, BCa 95% CI: -0.224, -0.095, p < 0.05) and self-efficacy (a*b = -0.080, BCa 95% CI: -0.158, -0.012, p < 0.05) significantly mediated the FSS-anxiety symptoms association. FSS and PC could help reduce depressive and anxiety symptoms among PLWHA employed full-time. PC fully mediates the associations of FSS with depressive and anxiety symptoms. In addition to enhancing FSS, PC development could be included in the prevention and treatment strategies for depressive and anxiety symptoms targeted at PLWHA employed full-time.

  2. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Science.gov (United States)

    Hu, Xingsheng; Zhang, Li; Shi, Yuankai; Zhou, Caicun; Liu, Xiaoqing; Wang, Dong; Song, Yong; Li, Qiang; Feng, Jifeng; Qin, Shukui; Xv, Nong; Zhou, Jianying; Zhang, Li; Hu, Chunhong; Zhang, Shucai; Luo, Rongcheng; Wang, Jie; Tan, Fenlai; Wang, Yinxiang; Ding, Lieming; Sun, Yan

    2015-01-01

    Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy. Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day). The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety. From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m) and 5.4 months (95%CI 3.1-7.9 m), respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA) according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127), diarrhea (12.6%, 16/127) and elevation of transaminase (15.7%, 20/127). In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy. ClinicalTrials.gov NCT02486354.

  3. Performance and emission of CI engine fuelled with camelina sativa oil

    International Nuclear Information System (INIS)

    Kruczyński, Stanisław W.

    2013-01-01

    Highlights: ► Camelina sativa as a potential source of alternative fuel. ► Neat camelina sativa oil as a fuel for CI engine. ► The engine performance and emissions of CI engine fuelled with neat camelina sativa oil. ► Comparison of rate of heat release for camelina sativa oil and diesel oil. - Abstract: The paper describes the results of the tests of CI Perkins 1104C-44 engine fuelled with camelina sativa oil. The engine was not especially calibrated for fuelling with the vegetable fuel. During the test the engine performance and emissions were analysed. For comparison the same speed characteristic was examined for standard fuelling of the engine with diesel oil. In order to understand the engine performance and emission the mass fraction burnt and the rate of heat release was calculated and compared for the same energy provided to the engine cylinder with the injected fuels. The results show that there is possible to receive relatively good engine performance for fuelling the engine with camelina sativa oil but there is a need to change the calibration parameters of the engine fuel system when the engine is fuelled with this fuel.

  4. Globalização: novo paradigma das ciências sociais

    Directory of Open Access Journals (Sweden)

    Octavio Ianni

    1994-08-01

    Full Text Available As ciências sociais estão sendo desafiadas a pensar a globalização do mundo. No fim do século XX, quando se anuncia o XXI, elas se defrontam com os dilemas que se abrem com a globalização das coisas, gentes e idéias. Há processos e estruturas sociais, econômicos, políticos, culturais e outros que apenas começam a ser estudados. Além do que é local, nacional e regional, colocam-se problemas novos e fundamentais com a emergência da sociedade global. As fronteiras geográficas e históricas, culturais e civilizatórias parecem modificar-se em direções e formas surpreendentes. Indivíduo, grupo, classe, coletividade e povo são colocados diante de outros horizontes. O próprio pensamento científico é desafiado a elaborar conceitos e interpretações para dar conta de realidades pouco conhecidas. As teorias da globalização, que começam a ser esboçadas, revelam o empenho das ciências sociais em explicar o que há de novo no que vai pelo mundo.Social sciences are now being challenged to think on the world's globalization. At the end of the twentieth century and dawn of the twenty first, they are faced with the dilemas that open up with the globalization of things, people and ideas: There are social, economical, political, cultural and other processes and structures that are just begining to be studied. Besides what is local, national and regional, new and fundamental problems appear with the rising global society. The geographic, historical, cultural and civilizatorian limits seem to change in surprising ways and directions. The individual, group, class, colectivity and people are put before other horizons. The scientific thinking itself is called upon to elaborate concepts and interpretations to account for little known realities. The globalization theories that are just being sketched show the efforts of Social Sciences to explain what is new going on in the world.

  5. Adolescents' physical activity is associated with previous and current physical activity practice by their parents.

    Science.gov (United States)

    Christofaro, Diego Giulliano Destro; Andersen, Lars Bo; Andrade, Selma Maffei de; Barros, Mauro Virgílio Gomes de; Saraiva, Bruna Thamyres Ciccotti; Fernandes, Rômulo Araújo; Ritti-Dias, Raphael Mendes

    The purpose of this study was to determine whether parents' current and previous physical activity practice is associated with adolescents' physical activity. The sample was composed of 1231 adolescents (14-17 years), and 1202 mothers and 871 fathers were interviewed. Weight and height of the adolescents were measured. Self-reported parents' weight and height were obtained. The current and previous physical activity levels (Baecke's questionnaire) of parents (during childhood and adolescence) and adolescents' physical activity levels were obtained using a questionnaire. The magnitude of the associations between parent and adolescent physical activity levels was determined by binary logistic regression (adjusted by sex, age, and socioeconomic level of adolescents and education level of parents). The current physical activity practice by parents was associated with adolescents' physical activity (p<0.001). The physical activities reported by parents in their childhood and adolescence were also associated with higher physical activity levels among adolescents. Adolescents whose parents were both physically active in the past and present were six times (OR=6.67 [CI=1.94-22.79]) more likely to be physically active compared to adolescents with no parents who were physically active in the past. The current and previous physical activities of parents were associated with higher levels of physical activity in adolescents, even after controlling for confounding factors. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  6. A Prospective Phase 2 Trial of Reirradiation With Stereotactic Body Radiation Therapy Plus Cetuximab in Patients With Previously Irradiated Recurrent Squamous Cell Carcinoma of the Head and Neck

    Energy Technology Data Exchange (ETDEWEB)

    Vargo, John A. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States); Ferris, Robert L. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States); Department of Otolaryngology, Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Ohr, James [Division Medical Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Clump, David A. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States); Davis, Kara S.; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T. [Department of Otolaryngology, Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Bauman, Julie E.; Gibson, Michael K. [Division Medical Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Branstetter, Barton F. [Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (United States); Heron, Dwight E., E-mail: herond2@umpc.edu [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States); Department of Otolaryngology, Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States)

    2015-03-01

    Purpose: Salvage options for unresectable locally recurrent, previously irradiated squamous cell carcinoma of the head and neck (rSCCHN) are limited. Although the addition of reirradiation may improve outcomes compared to chemotherapy alone, significant toxicities limit salvage reirradiation strategies, leading to suboptimal outcomes. We therefore designed a phase 2 protocol to evaluate the efficacy of stereotactic body radiation therapy (SBRT) plus cetuximab for rSCCHN. Methods and Materials: From July 2007 to March 2013, 50 patients >18 years of age with inoperable locoregionally confined rSCCHN within a previously irradiated field receiving ≥60 Gy, with a Zubrod performance status of 0 to 2, and normal hepatic and renal function were enrolled. Patients received concurrent cetuximab (400 mg/m{sup 2} on day −7 and then 250 mg/m{sup 2} on days 0 and +8) plus SBRT (40-44 Gy in 5 fractions on alternating days over 1-2 weeks). Primary endpoints were 1-year locoregional progression-free survival and National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 graded toxicity. Results: Median follow-up for surviving patients was 18 months (range: 10-70). The 1-year local PFS rate was 60% (95% confidence interval [CI]: 44%-75%), locoregional PFS was 37% (95% CI: 23%-53%), distant PFS was 71% (95% CI: 54%-85%), and PFS was 33% (95% CI: 20%-49%). The median overall survival was 10 months (95% CI: 7-16), with a 1-year overall survival of 40% (95% CI: 26%-54%). At last follow-up, 69% died of disease, 4% died with disease, 15% died without progression, 10% were alive without progression, and 2% were alive with progression. Acute and late grade 3 toxicity was observed in 6% of patients respectively. Conclusions: SBRT with concurrent cetuximab appears to be a safe salvage treatment for rSCCHN of short overall treatment time.

  7. A Prospective Phase 2 Trial of Reirradiation With Stereotactic Body Radiation Therapy Plus Cetuximab in Patients With Previously Irradiated Recurrent Squamous Cell Carcinoma of the Head and Neck

    International Nuclear Information System (INIS)

    Vargo, John A.; Ferris, Robert L.; Ohr, James; Clump, David A.; Davis, Kara S.; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T.; Bauman, Julie E.; Gibson, Michael K.; Branstetter, Barton F.; Heron, Dwight E.

    2015-01-01

    Purpose: Salvage options for unresectable locally recurrent, previously irradiated squamous cell carcinoma of the head and neck (rSCCHN) are limited. Although the addition of reirradiation may improve outcomes compared to chemotherapy alone, significant toxicities limit salvage reirradiation strategies, leading to suboptimal outcomes. We therefore designed a phase 2 protocol to evaluate the efficacy of stereotactic body radiation therapy (SBRT) plus cetuximab for rSCCHN. Methods and Materials: From July 2007 to March 2013, 50 patients >18 years of age with inoperable locoregionally confined rSCCHN within a previously irradiated field receiving ≥60 Gy, with a Zubrod performance status of 0 to 2, and normal hepatic and renal function were enrolled. Patients received concurrent cetuximab (400 mg/m 2 on day −7 and then 250 mg/m 2 on days 0 and +8) plus SBRT (40-44 Gy in 5 fractions on alternating days over 1-2 weeks). Primary endpoints were 1-year locoregional progression-free survival and National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 graded toxicity. Results: Median follow-up for surviving patients was 18 months (range: 10-70). The 1-year local PFS rate was 60% (95% confidence interval [CI]: 44%-75%), locoregional PFS was 37% (95% CI: 23%-53%), distant PFS was 71% (95% CI: 54%-85%), and PFS was 33% (95% CI: 20%-49%). The median overall survival was 10 months (95% CI: 7-16), with a 1-year overall survival of 40% (95% CI: 26%-54%). At last follow-up, 69% died of disease, 4% died with disease, 15% died without progression, 10% were alive without progression, and 2% were alive with progression. Acute and late grade 3 toxicity was observed in 6% of patients respectively. Conclusions: SBRT with concurrent cetuximab appears to be a safe salvage treatment for rSCCHN of short overall treatment time

  8. The radiation shielding potential of CI and CM chondrites

    Science.gov (United States)

    Pohl, Leos; Britt, Daniel T.

    2017-03-01

    Galactic Cosmic Rays (GCRs) and Solar Energetic Particles (SEPs) pose a serious limit on the duration of deep space human missions. A shield composed of a bulk mass of material in which the incident particles deposit their energy is the simplest way to attenuate the radiation. The cost of bringing the sufficient mass from the Earth's surface is prohibitive. The shielding properties of asteroidal material, which is readily available in space, are investigated. Solution of Bethe's equation is implemented for incident protons and the application in composite materials and the significance of various correction terms are discussed; the density correction is implemented. The solution is benchmarked and shows good agreement with the results in literature which implement more correction terms within the energy ranges considered. The shielding properties of CI and CM asteroidal taxonomy groups and major asteroidal minerals are presented in terms of stopping force. The results show that CI and CM chondrites have better stopping properties than Aluminium. Beneficiation is discussed and is shown to have a significant effect on the stopping power.

  9. Representações de ciência e religião no espiritismo Kardecista: antigas e novas configurações

    Directory of Open Access Journals (Sweden)

    Lewgoy, Bernardo

    2006-01-01

    Full Text Available A partir de uma reflexão inicial sobre as permanências e transformações nas representações de "ciência" e "religião" no esperitismo kardecista, bem como de seu papel na formação de uma identidade religiosa forte, afirma-se que há uma afinidade entre este problema e as dificuldades metodológicas e armadilhas lingüísticas na representação do espiritismo.

  10. Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review

    Directory of Open Access Journals (Sweden)

    Mugambi Mary N

    2012-10-01

    Full Text Available Abstract Background Synbiotics, probiotics or prebiotics are being added to infant formula to promote growth and development in infants. Previous reviews (2007 to 2011 on term infants given probiotics or prebiotics focused on prevention of allergic disease and food hypersensitivity. This review focused on growth and clinical outcomes in term infants fed only infant formula containing synbiotics, probiotics or prebiotics. Methods Cochrane methodology was followed using randomized controlled trials (RCTs which compared term infant formula containing probiotics, prebiotics or synbiotics to conventional infant formula with / without placebo among healthy full term infants. The mean difference (MD and corresponding 95% confidence intervals (CI were reported for continuous outcomes, risk ratio (RR and corresponding 95% CI for dichotomous outcomes. Where appropriate, meta-analysis was performed; heterogeneity was explored using subgroup and sensitivity analyses. If studies were too diverse a narrative synthesis was provided. Results Three synbiotic studies (N = 475, 10 probiotics studies (N = 933 and 12 prebiotics studies (N = 1563 were included. Synbiotics failed to significantly increase growth in boys and girls. Use of synbiotics increased stool frequency, had no impact on stool consistency, colic, spitting up / regurgitation, crying, restlessness or vomiting. Probiotics in formula also failed to have any significant effect on growth, stool frequency or consistency. Probiotics did not lower the incidence of diarrhoea, colic, spitting up / regurgitation, crying, restlessness or vomiting. Prebiotics in formula did increase weight gain but had no impact on length or head circumference gain. Prebiotics increased stool frequency but had no impact on stool consistency, the incidence of colic, spitting up / regurgitation, crying, restlessness or vomiting. There was no impact of prebiotics on the volume of formula tolerated, infections and gastrointestinal

  11. Os cursos de Ciência da Informação no Brasil e em Portugal: perspectivas diacrônicas Cursos de Ciencia de la Informacion en Brasil y en Portugal: perspectivas diacrónicas

    Directory of Open Access Journals (Sweden)

    Terezinha Batista de Souza

    2009-10-01

    Full Text Available Apresenta uma breve retrospectiva histórica da Ciência da Informação (CI no Brasil e em Portugal. No Brasil a C.I foi introduzida na década de 70 com a implementação do Mestrado, no Instituto Brasileiro de Bibliografia e Documentação (IBBD e em Portugal surgiu a partir dos cursos de pós-graduação em Ciências Documentais que evoluíram no sentido da adoção do termo Ciência da Informação, tendo em vista a implementação, em 2001, num esforço conjunto entre a Faculdade de Engenharia e a Faculdade de Letras da primeira Licenciatura em CI. Neste sentido mostra as as diferenças e semelhanças, bem como o quadro atual da CI nos dois países.

  12. PROJECT CI-NERGY: TOWARDS AN INTEGRATED ENERGY URBAN PLANNING SYSTEM FROM A DATA MODELLING AND SYSTEM ARCHITECTURE PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    G. Agugiaro

    2017-09-01

    Full Text Available Growing urbanisation, its related environmental impacts, and social inequalities in cities are challenges requiring a holistic urban planning perspective that takes into account the different aspects of sustainable development. One crucial point is to reconcile urban planning with environmental targets, which include decreasing energy demand and CO2 emissions, and increasing the share of renewable energy. Within this context, the project CI-NERGY aims to develop urban energy modelling, simulation and optimisation methods and tools to support decision making in urban planning. However, there are several barriers to the implementation of such tools, such as: fragmentation of involved disciplines, different stakeholders, multiplicity of scales in a city and extreme heterogeneity of data regarding all the processes to be addressed. Project CI-NERGY aims, among other goals, at overcoming these barriers, and focuses on two case study cities, Geneva in Switzerland and Vienna in Austria. In particular, project CI-NERGY faces several challenges starting with different cities, heterogeneous data sources and simulation tools, diverse user groups and their individual needs. This paper describes the experiences gathered during the project. After giving a brief overview of the project, the two case study cities, Geneva and Vienna, are briefly presented, and the focus shifts then on overall system architecture of the project, ranging from urban data modelling topics to the implementation of a Service-Oriented Architecture. Some of the challenges faced, the solutions found, as well some plans for future improvements are described and commented.

  13. Are platelet-rich products necessary during the arthroscopic repair of full-thickness rotator cuff tears: a meta-analysis.

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    Qiang Zhang

    Full Text Available BACKGROUND: Platelet-rich products (PRP are widely used for rotator cuff tears. However, whether platelet-rich products produce superior clinical or radiological outcomes is controversial. This study aims to use meta-analysis to compare clinical and radiological outcomes between groups with or without platelet-rich products. METHODS: The Pubmed, Embase, and Cochrane library databases were searched for relevant studies published before April 20, 2013. Studies were selected that clearly reported a comparison between the use or not of platelet-rich products. The Constant, ASES, UCLA, and SST scale systems and the rotator cuff retear rate were evaluated. The weighted mean differences and relative risks were calculated using a fixed-effects model. RESULTS: Seven studies were enrolled in this meta-analysis. No significant differences were found for the Constant scale (0.73, 95% CI, -1.82 to 3.27, P=0.58, ASES scale (-2.89, 95% CI, -6.31 to 0.53, P=0.1, UCLA scale (-0.79, 95% CI, -2.20 to 0.63, P=0.28, SST scale (0.34, 95% CI, -0.01 to 0.69, P=0.05, and the overall rotator cuff retear rate (0.71, 95% CI, 0.48 to 1.05, P=0.08. Subgroup analysis according to the initial tear size showed a lower retear rate in small- and medium-sized tears (0.33, 95% CI, 0.12 to 0.91, P=0.03 after platelet-rich product application but no difference for large- and massive-sized tears (0.86, 95% CI, 0.60 to 1.23, P=0.42. CONCLUSION: In conclusion, the meta-analysis suggests that the platelet-rich products have no benefits on the overall clinical outcomes and retear rate for the arthroscopic repair of full-thickness rotator cuff tears. However, a decrease occurred in the rate of retears among patients treated with PRP for small- and medium-sized rotator cuff tears but not for large- and massive-sized tears. LEVEL OF EVIDENCE: Level II.

  14. Detectando misticismo quântico em livros publicados no Brasil com Ciência de Dados

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    Mairus Disconzi de Moura

    2017-12-01

    Full Text Available As livrarias têm sido inundadas por títulos incluindo a palavra “quântica”, mas de caráter do chamado “misticismo quântico”, o qual propõe a existência de ligações entre a mecânica quântica e o misticismo oriental, levando a sérios equívocos. Este trabalho tem como objetivo identificar termos que possam ajudar os leitores, especialmente professores do ensino médio, a reconhecer a qual dessas categorias um livro pertence, antes mesmo de lê-lo, ajudando a quebrar o círculo vicioso de estudantes que aprendem pseudociência e a transmitem como verdade. Os catálogos on-line das quatro maiores livrarias do Brasil foram pesquisados por livros que contêm as palavras “quântica” ou “quântico” em seus títulos ou em suas sinopses. O banco de dados resultante foi examinado com a ajuda de técnicas de ciência de dados e recursos de mineração de dados textuais da linguagem de programação R. Foram identificados 22 termos que discriminam com uma acurácia de 94% entre as categorias "misticismo quântico" e popularização científica ou ciência.

  15. Humanidades e ciência: uma leitura a partir da Bioética de Van Rensselaer (V. R. Potter

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    Diego Carlos Zanella

    Full Text Available A Bioética surgiu em um momento em que a distância entre a ciência e as humanidades parecia intransponível. Em seu surgimento, a Bioética possuía um apelo para superar essa distância que se revelava fatal para o futuro desenvolvimento da humanidade e para a manutenção das condições de vida nesse planeta. É nesse contexto que V. R. Potter propôs seu conceito original de Bioética como uma integração entre a Biologia e os valores humanos - especialmente a filosofia moral - para orientar a sobrevivência humana. Nesse sentido, o presente texto procurará desenvolver o significado do conceito de Bioética para V. R. Potter e o problema das “duas culturas”, isto é, da necessidade de construção de um diálogo entre as humanidades e a ciência, buscando uma convergência da relação ética de todos os saberes em torno do cuidado da vida.

  16. Freire e Vigotski no contexto da Educação em Ciências: aproximações e distanciamentos

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    Simoni Tormöhlen Gehlen

    Full Text Available No contexto da Educação em Ciências, as concepções de Paulo Freire e Lev S. Vigotski, individualmente, têm contribuído para a configuração de novas perspectivas de análise e teorização do conhecimento científico produzido e apropriado pelos sujeitos. O estudo teórico apresentou indicativos de que as idéias de Freire e Vigotski aproximam-se em três aspectos: a a valorização do conhecimento cotidiano; b as semelhanças entre o papel dos especialistas em Freire e dos sujeitos mais capazes em Vigotski e c a conscientização; e apresentam distanciamentos em dois: a na gênese do conhecimento e b no ponto de partida do processo de aprendizagem. Além do mais, sinaliza-se que a possível complementaridade das idéias dos autores pode enriquecer propostas curriculares para a Educação em Ciências.

  17. Transformações necessárias para o avanço da Enfermagem como ciência do cuidar

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    Denise Elvira Pires de Pires

    2013-09-01

    Full Text Available Objetivou-se refletir acerca dos desafios para fortalecer a Enfermagem enquanto ciência do cuidar. Sustenta-se na teoria sociológica articulando três abordagens: do materialismo histórico-dialético sobre o processo de trabalho em saúde e enfermagem; da sociologia das profissões em uma perspectiva crítica; e da filosofia da ciência. A argumentação está organizada considerando aspectos da Enfermagem enquanto disciplina, trabalho e profissão da saúde. Sustenta que a produção do conhecimento deve ser orientada pela finalidade do trabalho de cuidar de seres humanos com carências de saúde e pela defesa das condições necessárias para um fazer seguro e responsável. Conclui que, para fortalecer a Enfermagem, é necessário produzir conhecimentos que fundamentem as ações de cuidado, assim como as lutas políticas em defesa da profissão, do direito universal à saúde e a cuidados seguros e de qualidade.

  18. PORÓWNANIE WYBRANYCH WŁAŚCIWOŚCI ZAPRAW ŻYWICZNYCH ZAWIERAJĄCYCH ODPADOWE TWORZYWA SZTUCZNE

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    Bernardeta DĘBSKA

    Full Text Available Racjonalna gospodarka odpadami stanowi jeden z priorytetowych kierunków szeroko rozumianej ochrony środowiska. Fakt umiejętnego zagospodarowania odpadów jest także ważny w kontekście zrównoważonego rozwoju społeczeństw. Do odpadów wyjątkowo uciążliwych dla środowiska zaliczyć należy tworzywa sztuczne. Wzrastające nieustannie ilości tego typu odpadów powodują występowanie problemów zarówno ekologicznych, jak i gospodarczych, co związane jest ze słabą biodegradacją tworzyw. Odpady te zaczęto wykorzystywać do produkcji materiałów budowlanych. Badania nad zagospodarowaniem odpadów z tworzyw sztucznych prowadzone są obecnie w różnych ośrodkach naukowych na świecie. W literaturze można znaleźć opisy wykorzystania odpadów m.in. polietylenu i polipropylenu, styropianu, poliuretanów, poliwęglanu, poliamidu, czy poli(chlorku winylu, jako modyfikatorów betonów i zapraw cementowych. W niniejszym artykule przedstawiono wyniki porównania wybranych właściwości czterech serii zapraw żywicznych zawierających różne odpady tworzyw sztucznych tj.: polipropylen (PP, polietylen (PE, piankę poliuretanową (PU oraz ekspandowany polistyren (EPS. Odpady te pochodziły odpowiednio z kubków po jogurtach, pianki podkładowej pod panele, pianki montażowej oraz płyt styropianowych. Zostały one rozdrobnione i stanowiły częściowy zamiennik kruszywa w zaprawach epoksydowych. Zbadano takie właściwości zapraw, jak: wytrzymałość na zginanie i ściskanie, gęstość objętościowa oraz nasiąkliwość. Wskazano materiał odpadowy, umożliwiający otrzymanie zaprawy cechującej się najkorzystniejszymi wartościami oznaczonych parametrów. Na podstawie uzyskanych wyników badań stwierdzono, że nawet przy 20% substytucji piasku odpadami tworzyw sztucznych, można otrzymać kompozyt charakteryzujący się bardzo dobrymi parametrami wytrzymałościowymi oraz niską nasiąkliwością wodą.

  19. Zróżnicowanie umiejętności początkowych w klasie pierwszej a efekt względnego wieku w klasie trzeciej

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    Krzysztof Konarzewski

    2015-06-01

    Full Text Available Celem artykułu jest weryfikacja dwóch hipotez. Pierwszą, według której zróżnicowanie umiejętności początkowych w klasie pierwszej jest ujemnie skorelowane z wiekiem startu szkolnego, sprawdzono na danych z Badania sześcio- i siedmiolatków na starcie szkolnym. Dyspersje wyników pomiaru umiejętności czytania i pisania (ale nie umiejętności matematycznych 1164 dzieci rozpoczynających naukę w klasie pierwszej istotnie malały w kolejnych kwartylach wieku. Drugą hipotezę, zgodnie z którą w oddziale szkolnym efekt względnego wieku w klasie trzeciej jest dodatnio skorelowany ze zróżnicowaniem początkowych umiejętności językowych i liczbowych w klasie pierwszej, sprawdzono na danych 4838 uczniów z 254 oddziałów trzeciej klasy szkoły podstawowej, zebranych w międzynarodowych badaniach osiągnięć szkolnych PIRLS i TIMSS 2011. Umiejętności początkowe oceniono na podstawie opinii rodziców. Hierarchiczna analiza regresji (przy kontroli płci i statusu społeczno-ekonomicznego rodziny ucznia oraz lokalizacji szkoły wykazała, że im większe było początkowe zróżnicowanie umiejętności językowych w oddziale (przy kontroli wieku uczniów, tym większa była różnica między osiągnięciami matematycznymi młodszych i starszych uczniów w klasie trzeciej. Wynik sugeruje, że pytanie o wiek, w jakim dzieci powinny rozpoczynać naukę w szkole, jest mniej ważne niż pytanie: Jak redukować zróżnicowanie umiejętności początkowych w oddziałach klasy pierwszej?

  20. Representações de ciência e religião no espiritismo Kardecista: antigas e novas configurações

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    Lewgoy, Bernardo

    2006-01-01

    Full Text Available A partir de uma reflexão inicial sobre as permanências e transformações nas representações de “ciência” e “religião” no espiritismo kardecista, bem como de seu papel na formação de uma identidade religiosa forte, afirma-se que há uma afinidade entre este problema e as dificuldades metodológicas e armadilhas lingüísticas na representação do espiritismo

  1. Conceito de Responsabilidade Social da Ciência da InformaçãoConcepto de Responsabilidad Social de la Ciencia de la Información

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    Esdras Renan Farias Dantas

    2012-01-01

    Full Text Available Introdução: A Responsabilidade Social prevê e estimula maior interação entre organizações empresariais e sociedade, governos e sociedade, instituições e mercados, e assim sucessivamente. Antes restrita à administração, à gestão e ao marketing, em especial, ao marketing social, nos dias de hoje, tende a se expandir para os demais campos, incluindo a Ciência da Informação.Objetivo: Apresentar conceituação em torno da expressão Responsabilidade Social da Ciência da Informação, pressupondo discussão teórica acerca da Ciência da Informação (CI e da Responsabilidade Social (RS.Metodologia: Análise de conteúdo, que favorece estudo quali-quantitativo a partir do estabelecimento de categorias. A análise das dissertações do Programa de Pós-Graduação em Ciência da Informação da Universidade Federal da Paraíba (PPGCI-UFPB acerca da temática RS permitiu nomear 13 agrupamentos.Resultados: O confronto entre teoria e apreciação das dissertações acata o pressuposto de que a CI como ciência essencialmente social mantém conceito sobre RS, embora não seja ele específico, e, sim, acompanhe as tendências contemporâneas, assumindo características da área da gestão. A Responsabilidade Social da Ciência da Informação volta-se, como maior frequência à promoção da cultura e a estudos sobre a função social das bibliotecas, o que corresponde à prática de uma Responsabilidade Social da Ciência da Informação voltada à Biblioteconomia. Eventualmente, isso pode se justificar pela incidência de dissertações apresentadas entre 1979 e 1987, quando o Programa mantinha área de concentração Sistemas de Bibliotecas Públicas.Conclusões: A responsabilidade social da Ciência da Informação é uma realidade, em termos mundiais, e, em especial, no Brasil, o que justifica sua inserção gradativa no Encontro Nacional de Pesquisa da Ciência da Informação, sob os auspícios da Associação Nacional de Pesquisa e

  2. Pulmonary Aspergillosis in a Previously Healthy 13-Year-Old Boy

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    Jonathan H. Rayment

    2016-01-01

    Full Text Available Chronic granulomatous disease (CGD is a rare, polygenic primary immunodeficiency. In this case report, we describe a previously healthy 13-year-old boy who presented with multifocal pulmonary aspergillosis and was subsequently diagnosed with an autosomal recessive form of chronic granulomatous disease. CGD has a variable natural history and age of presentation and should be considered when investigating a patient with recurrent or severe infections with catalase-positive organisms.

  3. Partial Factors in Modelling of Steel Structures Reliability According to Eurocodes / Współczynniki Częściowe W Eurokodowym Modelu Niezawodności Konstrukcji Stalowych

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    Stachura Zbigniew

    2015-03-01

    Full Text Available Stan graniczny nośności konstrukcji, projektowanej w tradycyjnym podejściu na podstawie efektów oddziaływań jest oceniany z niezawodnościowego modelu szeregowego. Kalibrację współczynników częściowych do nośności przeprowadza się wówczas na podstawie analizy niezawodności pojedynczego elementu konstrukcji (pręta lub węzła. Eurokod stalowy [4] wprowadził zasady projektowania bazujące na bardziej złożonych modelach nośności niż w [8], gdyż stan graniczny można ocenić na podstawie warunku stateczności technicznej podukładu konstrukcji lub w ogólności, jak przedstawia to warunek (2.1 - na podstawie punktu granicznego na ścieżce równowagi wyznaczonej dla nieidealnego modelu całej konstrukcji. Pojawia się pytanie, czy stosowanie do nośności wyznaczonej na podstawie bardziej złożonych modeli mechaniki konstrukcji współczynników częściowych wyspecyfikowanych do oceny nośności pojedynczych elementów prowadzi do bezpiecznych oszacowań. Kalibracja współczynników częściowych w metodzie stanów granicznych może być dokonana przy różnych założeniach wyjściowych. Model niezawodności i ogólne zasady przyjętego w eurokodach rozdziału docelowego wskaźnika niezawodności na składowe odnoszące się do ustalenia obliczeniowych oddziaływań i ich kombinacji oraz do ustalania nośności obliczeniowej zostały podane w eurokodzie [1]. W artykule przedstawiono zagadnienia dotyczące przyjęcia współczynników częściowych do nośności układu lub podukładu konstrukcyjnego. Opisano eurokodową procedurę wykorzystującą wyniki badań doświadczalnych do kalibracji współczynników częściowych do nośności.

  4. Free Surface of the Liquid-Gas Phase Separation as a Measuring Membrane of a Device for Measuring Small Hydrostatic Pressure Difference Values / Powierzchnia Swobodna Rozdziału Faz Ciecz-Gaz Jako Membrana Pomiarowa Urządzenia Do Pomiaru Małych Wartości Różnicy Ciśnienia Hydrostatycznego

    Science.gov (United States)

    Filipek, Wiktor; Broda, Krzysztof; Branny, Marian

    2015-03-01

    to the broader considerations related to uncertainty of the proposed method's measurements, due to the authors' awareness that this is the first prototype of such a device and, on the basis of this experience, another one will be built and tested. The observations and numerical analysis of the image formed on the screen by the passage of a laser beam through the free surface of the liquid-gas separation show that at low values of pressure difference, the bubble acts as a membrane shifting in the direction of lower pressure, in such way that the displacement is proportional to the pressure difference at both ends of the bubble. The proprietary method of numerical data processing presented in this article, based on analysis of the intensity of color change in a frame moving along a selected line outside of visual changes in the image of the laser beam after passing through the test structure, provided a tool to create first mathematical models to describe the observed changes (2),(3). Presented in this article method of measuring the difference between the free surface levels in two containers, and hence the measurement of hydrostatic pressure difference provides a new tool for laboratory measurements in the fields of science, which were previously unattainable. Do poprawnego opisu przepływu płynu przez ośrodek porowaty niezbędna jest znajomość rozkładu ciśnienia. O ile dla dużych liczb Reynoldsa (przepływy turbulentne) pomiar ciśnienia dostępnymi na rynku przyrządami nie stanowi większego problemu, to dla przepływów laminarnych cieczy (tj. dla liczb Re (Bear, 1988; Duckworth, 1983; Troskolański, 1957) z zakresu 0.01 do 3) nie ma na rynku przyrządów o wystarczającej dokładności. Przyczyny powodujące taką sytuację zostały omówione w poprzednich opracowaniach (Broda i Filipek, 2012, 2013), Dlatego większość prac dotyczących tego zagadnienia dotyczy badań rozkładu prędkości medium filtrującego przez badany ośrodek (Bear, 1988) lub rozk

  5. Informação como objeto para construção do corpus interdisciplinar entre Ciência da Informação e Ciência da Administração | Information from object to construction to interdisciplinary corpus between Information Science and Administrative Science

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    Joaquim Francisco Cavalcante de Oliveira

    2011-03-01

    Full Text Available Resumo Descrição e análise dos fundamentos teóricos e procedimentos metodológicos para a construção de um corpus interdisciplinar, compreendido como “o conjunto de categorias interdisciplinares afins e de significados próximos, valorizados por duas ou mais Ciências”, nesta pesquisa entre a Ciência da Informação e a Ciência da Administração, com base na informação e gestão da informação. As etapas de seu desenvolvimento incluem o referencial teórico em torno da interdisciplinaridade das áreas estudadas, especialmente Heckhausen; pesquisa documental para identificação dos autores de Ciência da Informação e de Ciência da Administração, identificados via Currículo Lattes e Diretório de Grupos de Pesquisa do CNPq e autores estrangeiros por meio do Google. A partir da análise de citação e a análise de conteúdo em revistas brasileiras de Administração e Ciência da Informação selecionadas e da identificação dos conceitos contidos em artigos, foi construído o corpus interdisciplinar. Esta metodologia tem aplicação mais ampla e pode ser adotada em pesquisas semelhantes de interdisciplinaridade de outros campos do conhecimento. Palavras-chave interdisciplinaridade; Ciência da Informação; Ciência da Administração; informação; metodologia da pesquisa; corpus interdisciplinar; gestão da informação. Abstract A description and analysis of the theoretical foundations and methodological procedures in the development of an interdisciplinary corpus, defined/described as “a group of related interdisciplinary categories and similar meanings, recognized by two or more Sciences”, the article presents results of research between Information Science and Administrative Science, based on information and information management. The stages of its development include the theoretical referential that surrounds the interdisciplinarity of the studied areas, especially Heckhausen: documental research for the

  6. New records of Libellula pulchella (Odonata: Libellulidae and Phyllogomphoides albrighti (Odonata: Gomphidae from the Cuatro Ciénegas Basin, Coahuila, Mexico Nuevos registros de Libellula pulchella (Odonata: Libellulidae y Phyllogomphoides albrighti (Odonata: Gomphidae para el valle de Cuatro Ciénegas, Coahuila, México

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    Enrique González-Soriano

    2012-09-01

    Full Text Available The first records of Libellula pulchella and Phyllogomphoides albrighti from Coahuila are reported. These records extend the known geographic range of Libellula pulchella south of Texas and Phyllogomphoides albrighti west of Nuevo León. The specimens were collected in the Cuatro Ciénegas Basin, one of the most biologically interesting areas for the study of aquatic insects.Se presentan los primeros registros de Libellula pulchella y Phyllogomphoides albrighti para Coahuila. Ambas especies extienden su distribución geográfica conocida más allá del sur del estado de Texas y más allá del oeste de Nuevo León, respectivamente. Los ejemplares fueron recolectados en la región del valle de Cuatro Ciénegas, uno de los lugares más interesantes para el estudio biológico de insectos con hábitos acuáticos en algún estadio.

  7. Culturas das Ciências Naturais Cultures of Natural Sciences

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    Maria Margaret Lopes

    2005-12-01

    Full Text Available Este artigo apresenta subsídios para o ensino de História das Ciências, considerando particularmente o campo da História da História Natural e das Ciências Naturais. Sem ser uma revisão completa da historiografia desses campos de conhecimento sobre o mundo natural, retoma alguns traços gerais desses longos processos de definição de campos disciplinares que se configuram desde a Renascença até o final do século XVIII. Considera diversas tradições culturais e historiográficas que contribuíram para os nossos entendimentos atuais, de como a História Natural do Renascimento foi abandonando seus antigos quadros conceituais, assumindo novas práticas e se constituindo nas tradições da História Natural do século XVIII. Comenta esses processos, em que tanto a Botânica, a Zoologia, a Mineralogia se individualizam como áreas de conhecimentos apoiadas em práticas locais e coleções globais, indo além de sua subordinação à utilidade médica; bem como suas organizações em áreas de conhecimento, por começarem a se colocar questões relativas à origem e à historicidade dos seres e processos naturais, dados os avanços das temáticas classificatórias e das discussões envolvendo temporalidades.This paper provides insights into the teaching of the History of Science, especially the field of the History of Natural History and Natural Sciences. Although not claiming to be a complete historiographic review of these areas of knowledge about the natural world, it outlines the general traits of the long process of definition of disciplines that were shaped from the Renaissance to the end of the XVIII century. It encompasses various cultural and historiographic traditions that contributed to our present understanding of how Renaissance Natural History abandoned its ancient conceptual frameworks and assumed new practices and shaped itself in the tradition of XVIII century Natural History. The paper comments on these processes by which

  8. Algumas considerações sobre o fazer científico realizadas a partir da análise dos modelos de ciência propostos por Taylor, Wundt e Watson

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    Bruno Alvarenga Ribeiro

    Full Text Available A história das ciências como um todo, incluindo a história das ciências humanas e, particularmente, a história da Psicologia, nos presenteia com exemplos de como às vezes o fazer científico é restringido aos lugares comuns da metodologia. Dessa forma, o objetivo deste artigo é refletir sobre a crença de que a ciência é o próprio método que ela utiliza, demonstrando que metodologias particulares decorrem da adoção de determinados pressupostos filosóficos também particulares, que podem levar o fazer científico a algumas incorreções, nem sempre refutáveis por questões de lógica.

  9. Influence of operating parameters on electrocoagulation of C.I. disperse yellow 3

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    Djamel Ghernaout

    2014-12-01

    Full Text Available This work deals with the electrocoagulation (EC process for an organic dye removal. The chosen organic dye is C.I. disperse yellow 3 (DY which is used in textile industry. Experiments were performed in batch mode using Al electrodes and for comparison purposes Fe electrodes. The experimental set-up was composed of 1 L beaker, two identical electrodes which are separated 2 cm from each other. The main operating parameters influencing EC process were examined such as pH, supporting electrolyte concentration CNaCl, current density i, and DY concentration. High performance EC process was shown during 45 min for 200 mg/L dye concentration at i = 350 A m-2 (applied voltage 12 V and CNaCl = 1 g L-1 reaching 98 % for pHs 3 and 10 and 99 % for pH 6. After 10 min, DY was also efficiently removed (86 % showing that EC process may be conveniently applied for textile industry wastewater treatment. EC using Fe electrodes exhibited slightly lower performance comparing EC using Al electrodes.

  10. A trajetória de Virgínia Schall: integrando Saúde, Educação, Ciência e Literatura

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    Denise Nacif Pimenta

    Full Text Available Resumo Este artigo apresenta a trajetória profissional de Virgínia Schall, interrompida precocemente, destacando sua atuação na integração dos campos da Saúde, da Educação e da Divulgação Científica no Brasil. A contextualização da sua produção acadêmica e literária como pesquisadora da Fundação Oswaldo Cruz permite demonstrar a contribuição de Virginia para o fortalecimento da instituição e para a formação de dezenas de pesquisadores e alunos. Com abordagem marcadamente inter e multidisciplinar, Virgínia foi pioneira no campo da Educação em Saúde, Ensino de Ciências e Divulgação Científica, tendo participado da implantação de dois cursos de pós-graduação e atuado regularmente como consultora ad hoc do CNPq, CAPES, SVS/MS e MEC, consolidando políticas públicas nacionais nas áreas referidas. Além de autora de diversos livros infanto-juvenis e informativos/materiais educativos sobre saúde, ambiente e ciência, Virginia concebeu o Museu da Vida na Fiocruz-RJ, como um espaço de integração entre ciência, cultura e sociedade, voltada para informação, educação em ciência, saúde e tecnologia. Foi também poetisa, integrante da Academia Feminina Mineira de Letras, produzindo diversificada e premiada obra literária em prosa e poesia.

  11. Wpływ miąższości reaktywnej warstwy drenażowej na odpływ fosforanów z zielonego dachu

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    Agnieszka Karczmarczyk

    2017-12-01

    Full Text Available Woda odciekająca z zielonego dachu może być zanieczyszczona zawiązkami fosforu. Źródłem tych zanieczyszczeń może być substrat dachowy. W pracy podjęto próbę określenia optymalnej proporcji miąższości warstwy drenażowej z materiału reaktywnego (MR do miąższości substratu (S stosowanego na zielonych dachach. Przeprowadzono doświadczenie kolumnowe, którego celem była ocena wpływu miąższości reaktywnej warstwy drenażowej wykonanej z Polonite® na wielkość redukcji fosforanów z odcieku. Potwierdzono, że substrat dachowy może być źródłem zanieczyszczenia fosforanami wody odprowadzanej z dachu zielonego. Wartość odprowadzonego ładunku wynosiła odpowiednio 0,091; 0,032 i 0,02 mg P-PO4 dla kolumn o proporcji S:MR=10:1, S:MR=10:2 i S:MR=10:5. Jako optymalne uznano zastosowanie warstwy substratu w stosunku do warstwy materiału reaktywnego w proporcji miąższości S:MR 10:2.

  12. A formação de Licenciados em Ciências Agrícolas/Agrárias: o conhecimento e suas conexões

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    Marco Antonio de Moraes

    2014-11-01

    Full Text Available http://dx.doi.org/10.5902/1984644413683Este trabalho visa identificar os perfis de formação dos licenciados de Ciências Agrícolas/Agrárias e os objetivos dos cursos que formam estes profissionais no Brasil. Neste estudo exploratório, os dados foram coletados através da Internet no site do MEC e das Instituições de Ensino Superior. O perfil geralmente proposto na formação do professor em Ciências Agrícolas/Agrícolas é amplo, com atuação em diferentes campos das Ciências Agrárias com finalidades econômicas, mas com atenção às questões sócio-políticas e culturais presentes no meio rural brasileiro. Percebe-se a intenção de formar licenciados que atendam alguns aspectos ou demandas regionais e que estejam preparados para as questões da atualidade. Destaca-se a preocupação com o desenvolvimento de algumas competências importantes na formação do profissional que irá atuar na educação escolar.

  13. A história da ciência na prática de professores portugueses: implicações para a formação de professores de ciências The history of science in portuguese teachers' practice: implications for science teachers education

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    Maria da Conceição Duarte

    2004-12-01

    Full Text Available O reconhecimento das limitações da educação científica tradicional para atuar numa sociedade que se reclama, cada vez mais, como "sociedade da informação e do conhecimento" conduziu à retomada da discussão sobre a necessidade de inovar e produzir novos currículos e novas formas de ensinar ciências. Esta idéia vai atravessar diferentes culturas e países, nomeadamente Portugal, conduzindo a importantes reformas ou reorganizações curriculares, onde a História da Ciência aparece como uma dimensão importante na promoção da cidadania e do conhecimento das ciências como cultura. Mas estarão os professores preparados para enfrentar esse novo desafio? Neste artigo procuraremos dar uma resposta a esta questão, com base tanto em resultados de estudos realizados em que se procurou investigar as práticas de professores portugueses e suas percepções relativamente à sua formação e à importância conferida à História da Ciência, quanto na análise dos currículos de formação de professores de ciências. Com base nesses resultados serão retiradas algumas implicações para a formação de professores.There are limitations of traditional Science Education in a society that more and more claims to be a "society of information and knowledge". It brings back the discussion about the need to innovate and produce new curricula and new approaches for science teaching. This idea will cross different cultures and countries, namely Portugal, leading to important curricular reforms or reorganizations, where the History of Science appears as an important dimension of the promotion of citizenship and of scientific knowledge as culture. But the following question arises: Are teachers prepared to face the new challenge? In this article we will try to give an answer to this question, building on results of research studies focused on Portuguese teachers' practices, their perceptions about their education and the importance they attach to the

  14. The Exploitation Problems Marine Light Constructions for Corrosion Resistance / Problemy Eksploatacyjne Lekkich Konstrukcji Morskich w Aspekcie Odporności Korozyjnej

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    Jurczak Wojciech

    2015-09-01

    Full Text Available Korozyjne obniżenie właściwości eksploatacyjnych materiałów stosowanych na konstrukcje morskie jest naturalnym zjawiskiem. Stopień obniżenia właściwości mechanicznych materiałów zastosowanych na konstrukcje okrętów zależą od składu chemicznego materiału konstrukcyjnego, warunków eksploatacyjnych (zasolenie, obciążenie oraz rodzaju zastosowanej ochrony przeciwkorozyjnej. W artykule przedstawiono problemy eksploatacyjne okrętów, których konstrukcje wykonano ze stopów aluminium oraz wyniki badań korozji naprężeniowej współczesnych, wysokowytrzymałych stopów aluminium. Dla podwyższenia bezpieczeństwa eksploatacji tych konstrukcji wprowadzono rejestrację potencjału korozyjnego na wybranych (zagrożonych obszarach nadbudówki okrętu projektu 620 wykonanej ze stopu 7020 celem monitorowania zagrożenia pęknięciem korozyjnym.

  15. Geneza reumatoidalnego zapalenia stawów a możliwości terapii

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    Stefan H. Mackiewicz

    2010-02-01

    Full Text Available Reumatoidalne zapalenie stawów należy do najbardziejzłożonych pod względem patogenetycznym chorób autoimmunologicznych.Czynniki (czynnik DR-β1 genetyczne i środowiskowestanowią o wrażliwości na chorobę. Nieznany mechanizm indukującypowoduje aktywację układu immunologicznego. Zakreszmian w różnych populacjach komórek i produkcja prozapalnychmediatorów chemicznych stwarza stan pewnego ,,chaosu biologicznego”.Kluczowe znaczenie ma derepresja genów w komórkachi przepływ sygnałów wewnątrz- i międzykomórkowych.Chorobę charakteryzuje bardzo indywidualny przebieg i nieprzewidywalnaodpowiedź na różne metody leczenia. Stosowane lekidziałają plejotropowo (metrotreksat – hamując proliferację aktywowanychkomórek bądź selektywnie na poszczególne elementyłańcucha patogenetycznego (antycytokiny.

  16. Leiomyosarcoma of the Prostate: Case Report and Review of 54 Previously Published Cases

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    Gerasimos P. Vandoros

    2008-01-01

    Full Text Available Prostate leiomyosarcoma is an extremely rare and highly aggressive neoplasm that accounts for less than 0.1% of primary prostate malignancies. We present a patient with primary leiomyosarcoma of the prostate and review 54 cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this uncommon tumor. Median survival was estimated at 17 months (95% C.I. 20.7–43.7 months and the 1-, 3-, and 5-year actuarial survival rates were 68%, 34%, and 26%, respectively. The only factors predictive of long-term survival were negative surgical margins and absence of metastatic disease at presentation. A multidisciplinary approach is necessary for appropriate management of this dire entity.

  17. Estabilidad temporal del C.I. y potencial de aprendizaje en niños superdotados: implicaciones diagnósticas

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    Mª Dolores Calero

    2014-05-01

    Full Text Available Tradicionalmente la determinación de la sobredotación se ha realizado con tests tradicionales de inteligencia. El principal argumento para hacerlo ha sido la estabilidad temporal de esta medida. En los últimos años algunos autores defienden una determinación temprana de la sobredotación en niños, aunque otros señalan que la determinación del C.I. en niños pequeños arroja un número importante de falsos positivos debido a la variabilidad de la medida de la inteligencia por influencia de diferentes factores tales como la plasticidad cerebral, la estimulación, etc., por lo que proponen el uso de índices complementarios para el diagnóstico de sobredotación. En este trabajo se realiza un estudio longitudinal de dos años a 49 niños de entre 5 y 9 años, -inicialmente identificados como superdotados-, para comprobar la estabilidad de su C.I. y de otras medidas tales como el potencial de aprendizaje y la memoria de trabajo. Los resultados muestran como las medidas de potencial de aprendizaje y memoria de trabajo permanecen estables en el tiempo mientras que el C.I. de un grupo de niños de menor edad no se mantiene en dicho periodo. Estos resultados señalan la utilidad de las medidas de P.A. como un índice complementario en la determinación de la sobredotación en niños pequeños.

  18. Association of Previous Clinical Breast Examination With Reduced Delays and Earlier-Stage Breast Cancer Diagnosis Among Women in Peru.

    Science.gov (United States)

    Romanoff, Anya; Constant, Tara Hayes; Johnson, Kay M; Guadiamos, Manuel Cedano; Vega, Ana María Burga; Zunt, Joseph; Anderson, Benjamin O

    2017-11-01

    Mammographic screening is impractical in most of the world where breast cancers are first identified based on clinical signs and symptoms. Clinical breast examination may improve early diagnosis directly by finding breast cancers at earlier stages or indirectly by heightening women's awareness of breast health concerns. To investigate factors that influence time to presentation and stage at diagnosis among patients with breast cancer to determine whether history of previous clinical breast examination is associated with earlier presentation and/or earlier cancer stage at diagnosis. In this cross-sectional analysis of individual patient interviews using a validated Breast Cancer Delay Questionnaire, 113 (71.1%) of 159 women with breast cancer treated at a federally funded tertiary care referral cancer center in Trujillo, Peru, from February 1 through May 31, 2015, were studied. Method of breast cancer detection and factors that influence time to and stage at diagnosis. Of 113 women with diagnosed cancer (mean [SD] age, 54 [10.8] years; age range, 32-82 years), 105 (92.9%) had self-detected disease. Of the 93 women for whom stage was documented, 45 (48.4%) were diagnosed with early-stage disease (American Joint Committee on Cancer [AJCC] stage 0, I, or II), and 48 (51.6%) were diagnosed with late-stage disease (AJCC stage III or IV). Mean (SD) total delay from symptom onset to initiation of treatment was 407 (665) days because of patient (mean [SD], 198 [449] days) and health care system (mean [SD], 241 [556] days) delay. Fifty-two women (46.0%) had a history of clinical breast examination, and 23 (20.4%) had undergone previous mammography. Women who underwent a previous clinical breast examination were more likely to have shorter delays from symptom development to presentation compared with women who had never undergone a previous clinical breast examination (odds ratio, 2.92; 95% CI, 1.30-6.60; P = .01). Women diagnosed with shorter patient delay were more

  19. Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011

    Science.gov (United States)

    Palmer, Benedict P.; Chalmers, Elizabeth A.; Hart, Daniel P.; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R. M.

    2014-01-01

    The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. PMID:25339360

  20. Contribuições de componentes da licenciatura em Ciências Biológicas na constituição do educador ambiental

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    Gabriela de Vargas de Rosa

    2015-12-01

    Full Text Available A educação ambiental é uma construção histórica de valores e responsabilidades, num processo de mudanças de atitudes quanto a relação ser humano e natureza, considerando a vida em sociedade. O objetivo do trabalho é verificar a contribuição da formação profissional na Licenciatura em Ciências Biológicas para a constituição do educador ambiental, numa perspectiva interdisciplinar do conhecimento. Para tanto, foram realizadas as análises das ementas e referências dos componentes curriculares Ecologia, Prática de Ensino I: Fundamentos teóricos e práticos em ciências e Prática de ensino VI: Prática de Pesquisa Biológica inscritos no Projeto Pedagógico do Curso de Ciências Biológicas da Universidade Regional do Noroeste do Estado do Rio Grande do Sul (UNIJUI, implantado em 2009. As discussões propiciadas a partir deste conhecimento, em sala de aula, proporcionam espaços de reflexão sobre a responsabilidade individual e coletiva na mudança de atitude quanto a relação com o ambiente.

  1. History and Philosophy of Science: a Phylogenetic approach História e filosofia da ciência: uma abordagem filogenética

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    James G. Lennox

    2001-12-01

    Full Text Available In the aftermath of Thomas Kuhn's The structure of scientific revolutions, there was a great deal of discussion about the relationship between the History of Science and the Philosophy of Science. A wider issue was at stake in these discussions: 'normativism' versus 'naturalism' in Epistemology. If the History of Science, at best, gives us reliable information about what actually occurred historically, how can it inform debates about such things as confirmation or explanation in Philosophy of Science? This essay makes a case for the centrality of historical investigation in the Philosophy of Science. I will defend what I term the 'Phylogenetic' approach to the Philosophy of Science. I will argue that since the foundations and dominant methods of a particular scientific field are shaped by its history, studying that History can give us considerable insight into conceptual and methodological problems in a particular Science. The case will be made both on general, philosophical grounds, and by compelling instantiation.A publicação de A estrutura das revoluções científicas de Thomas Khun resultou em uma grande discussão sobre a relação entre a história da ciência e a filosofia da ciência. Nessa discussão, o que estava em jogo era algo bem mais abrangente, isto é, o 'normativismo' versus o 'naturalismo' em epistemologia. Se a história da ciência, na melhor das hipóteses, nos dá informações confiáveis quanto ao que realmente ocorreu historicamente, como é que ela pode auxiliar os debates da filosofia da ciência sobre aspectos tais como confirmação e explicação? O presente artigo defende a centralização da investigação histórica para a filosofia da ciência. O autor defende o que ele chama de abordagem 'filogenética' à filosofia da ciência, argumentando que, uma vez que a as bases e métodos que prevalecem em uma área científica são moldados pela sua história, estudar esta história pode esclarecer

  2. Ciências possíveis em Machado de Assis: teatro e ciência na educação científica Possible sciences in Machado de Assis: theatre and science in scientific education

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    Thelma Lopes Carlos Gardair

    2009-01-01

    Full Text Available Este estudo busca compreender como a relação entre teatro e ciência pode ser profícua na educação em ciências, a partir de atividade desenvolvida no "Ciência em Cena", área do Museu da Vida, Fundação Oswaldo Cruz/RJ. A atividade consiste na apresentação da peça "Lição de Botânica", de Machado de Assis, seguida de debate e exibição de cd-rom. Neste artigo foi analisado o primeiro semestre da temporada de 2007, que reuniu 1.827 pessoas. As 171 perguntas elaboradas durante os debates realizados após trinta espetáculos, foram registradas por escrito e interpretadas com base em critérios metodológicos da "análise de conteúdo". O exame dos dados permite discutir a interface entre processos de criação artística e educação científica. Tal discussão está ancorada na perspectiva problematizadora da educação segundo Freire e no entendimento, tal qual Maturana, da educação como um espaço dialógico de convivência, um lugar de perene criação/recriação da vida.This paper investigates how the relationship between art and science can be productive in science education, from an activity developed in "Science on Scene", a visitor area of the Museum of Life, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The activity consists of the presentation of the play "Lessons of Botany", by Machado de Assis, followed by debate and the playing of a CD-rom. In this paper the first semester of the 2007 season was analyzed, including 1.827 spectators. The 171 questions elaborated during the debates carried through after thirty performances, had been registered in writing and interpreted on the basis of "Content Analysis". Examination of the data stimulates the discussion about the interface between the processes of artistic creation and scientific education. This discussion is based within a Freire critical perspective of education, and is seen as a dialogic space, a place of permanent creation/recreation of life.

  3. Impact of previous open renal surgery on the outcomes of subsequent percutaneous nephrolithotomy: a meta-analysis.

    Science.gov (United States)

    Hu, Henglong; Lu, Yuchao; Cui, Lei; Zhang, Jiaqiao; Zhao, Zhenyu; Qin, Baolong; Wang, Yufeng; Wang, Qing; Wang, Shaogang

    2016-04-28

    The aim of this study was to systematically compare the perioperative outcomes of percutaneous nephrolithotomy in patients with or without previous ipsilateral open renal surgery (POS). Systematic searches of the PubMed, Web of Science and Cochrane Library databases were used to identify relevant studies, and, following literature screening and data extraction, a meta-analysis was performed. 17 retrospective cohort studies involving 4833 procedures (4784 patients) were included. No statistically significant differences were observed between patients with or without POS in terms of supracostal access; single/multiple tracts; metal dilator need; time required to access the collecting system; fluoroscopic duration; demand for analgesics; hospital stay; final stone-free rate; and risk of developing certain complications (eg, fever, haemorrhage, haemo/hydro/pneumothorax, blood transfusion, urinary tract infection and sepsis) as well as regarding the risk of total complications. Patients with POS, however, had a greater drop in haemoglobin (weighted mean difference (WMD), 1.78 g/L; 95% CI 1.09 to 2.47; pPOS also had a lower initial stone-free rate (RR, 0.96; 95% CI 0.92 to 0.99; p=0.007) and more secondary treatment (RR, 1.61; 95% CI 1.09 to 2.37; p=0.02). Sensitivity analysis produced comparable results except for differences in operative time and initial stone-free rate, which did, however, prove to be statistically insignificant (p=0.16 and 0.69, respectively). Current evidence suggests that percutaneous nephrolithotomy in patients with POS is associated with a significantly greater drop in haemoglobin, higher risk of requiring angiographic embolisation and auxiliary procedures, potentially longer operative time, and lower initial stone-free rate than percutaneous nephrolithotomy in patients without POS. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  4. Dissociation in decision bias mechanism between probabilistic information and previous decision

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    Yoshiyuki eKaneko

    2015-05-01

    Full Text Available Target detection performance is known to be influenced by events in the previous trials. It has not been clear, however, whether this bias effect is due to the previous sensory stimulus, motor response, or decision. Also it remains open whether or not the previous trial effect emerges via the same mechanism as the effect of knowledge about the target probability. In the present study, we asked normal human subjects to make a decision about the presence or absence of a visual target. We presented a pre-cue indicating the target probability before the stimulus, and also a decision-response mapping cue after the stimulus so as to tease apart the effect of decision from that of motor response. We found that the target detection performance was significantly affected by the probability cue in the current trial and also by the decision in the previous trial. While the information about the target probability modulated the decision criteria, the previous decision modulated the sensitivity to target-relevant sensory signals (d-prime. Using functional magnetic resonance imaging, we also found that activation in the left intraparietal sulcus was decreased when the probability cue indicated a high probability of the target. By contrast, activation in the right inferior frontal gyrus was increased when the subjects made a target-present decision in the previous trial, but this change was observed specifically when the target was present in the current trial. Activation in these regions was associated with individual-difference in the decision computation parameters. We argue that the previous decision biases the target detection performance by modulating the processing of target-selective information, and this mechanism is distinct from modulation of decision criteria due to expectation of a target.

  5. Egzemplifikacja Tomograficznej Metody Do Oceny Jakości Połączeń Spawanych Ze Stopu EN 5754 H22

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    Błachnio Józef

    2016-12-01

    Full Text Available Jakość połączeń spawanych zależna jest od wielu czynników. Przedmiotowe normy określają warunki techniczne oceny jakościowej spawów, co stanowi podstawę do uznania połączenia za zgodne z wymaganiami lub wadliwe. W praktyce wykonanie połączenia spawanego całkowicie pozbawionego wad jest trudne. Do kontroli wewnętrznej struktury połączenia wykorzystać można nieniszczącą metodę z zastosowaniem przemysłowego tomografu komputerowego. Ta nowoczesna metoda diagnozowania łączy badanie rentgenowskie z zaawansowaną technologią komputerową. Podstawową zaletą tomografii komputerowej jest badanie obiektów w trzech wymiarach oraz możliwość wykonania rekonstrukcji przestrzennych. Celem artykułu jest omówienie wykorzystania tej metody do oceny jakości połączeń spawanych stopów aluminium. Możliwości tomografii komputerowej przedstawiono na przykładzie próbek spawalniczych wykonanych metodą TIG przy różnych parametrach procesu. Dokonano analizy jakości próbek wykazujących najmniejsze i największe zewnętrzne, jak również wewnętrzne wady spawalnicze.

  6. Static Code Analysis with Gitlab-CI

    CERN Document Server

    Datko, Szymon Tomasz

    2016-01-01

    Static Code Analysis is a simple but efficient way to ensure that application’s source code is free from known flaws and security vulnerabilities. Although such analysis tools are often coming with more advanced code editors, there are a lot of people who prefer less complicated environments. The easiest solution would involve education – where to get and how to use the aforementioned tools. However, counting on the manual usage of such tools still does not guarantee their actual usage. On the other hand, reducing the required effort, according to the idea “setup once, use anytime without sweat” seems like a more promising approach. In this paper, the approach to automate code scanning, within the existing CERN’s Gitlab installation, is described. For realization of that project, the Gitlab-CI service (the “CI” stands for "Continuous Integration"), with Docker assistance, was employed to provide a variety of static code analysers for different programming languages. This document covers the gene...

  7. WŁAŚCIWOŚCI FIZYCZNO-CHEMICZNE BIOMASY OTRZYMANEJ W NOWEJ TECHNOLOGII PRZETWARZANIA OSADÓW ŚCIEKOWYCH „BIONOR SLUDGE”

    Directory of Open Access Journals (Sweden)

    January BIEŃ

    2016-06-01

    Full Text Available Obecny stan prawny w pewien sposób generuje poszukiwania i rozwój nowoczesnych technologii pozwalających na rozwiązanie problemu zagospodarowania osadów ściekowych w Polsce nie tylko dla dużych obiektów, ale przede wszystkim dla instalacji małych i średnich, ponieważ to z nich głównie osady ściekowe obecnie trafiają na składowiska odpadów. Celem pracy jest ocena funkcjonowania prototypowej linii technologicznej do przetwarzania osadów ściekowych i ocena uzyskanej z tej technologii biomasy. Technologia Bionor Sludge stanowi rozwiązanie przeznaczone dla gminnych oczyszczalni o przepustowości do 1000 m3*d-1. Powstające osady ściekowe odpowiednio przetworzone w instalacji mogą zostać zagospodarowane dwojako: jako kompost lub jako wsad do instalacji termicznej, gdzie mogą stanowić biomasę zgodnie z ustawą o OZE. W pracy przedstawiono materiały pozwalające na wstępną ocenę jakości uzyskiwanego produktu pod kątem potencjału nawozowego i energetycznego. Bionor Sludge to technologia, która polega na przekierowaniu, w możliwie największym stopniu, energii chemicznej zgromadzonej w ściekach komunalnych do osadów stanowiących rezerwuar substancji organicznej. Cały układ technologiczny oczyszczania ścieków i przeróbki osadów charakteryzuje się również wysoką efektywnością i elastycznością pracy przy modułowej zabudowie. Możliwe i w pełni zasadne jest zastosowanie wybranych elementów omawianej instalacji w ramach modernizacji istniejących obiektów. Technologia Bionor Sludge dzięki swej innowacyjności i założeniom o możliwie najlepszym wykorzystaniu zasobów nawozowych i energetycznych, umożliwia racjonalne funkcjonowanie oczyszczalni i tym samym znaczące odciążenie budżetu gmin i ostatecznie ich mieszkańców.

  8. Addition by subtraction in coupled-cluster theory: a reconsideration of the CC and CI interface and the nCC hierarchy.

    Science.gov (United States)

    Bartlett, Rodney J; Musiał, Monika

    2006-11-28

    The nCC hierarchy of coupled-cluster approximations, where n guarantees exactness for n electrons and all products of n electrons are derived and applied to several illustrative problems. The condition of exactness for n=2 defines nCCSD=2CC, with nCCSDT=3CC and nCCSDTQ=4CC being exact for three and four electrons. To achieve this, the minimum number of diagrams is evaluated, which is less than in the corresponding CC model. For all practical purposes, nCC is also the proper definition of a size-extensive CI. 2CC is also an orbitally invariant coupled electron pair approximation. The numerical results of nCC are close to those for the full CC variant, and in some cases are closer to the full CI reference result. As 2CC is exact for separated electron pairs, it is the natural zeroth-order approximation for the correlation problem in molecules with other effects introduced as these units start to interact. The nCC hierarchy of approximations has all the attractive features of CC including its size extensivity, orbital invariance, and orbital insensitivity, but in a conceptually appealing form suited to bond breaking, while being computationally less demanding. Excited states from the equation of motion (EOM-2CC) are also reported, which show results frequently approaching those of EOM-CCSDT.

  9. A Dialética do Senhor e do Escravo como Fundamento da Sociologia enquanto Ciência Humana

    Directory of Open Access Journals (Sweden)

    Henrique Raskin

    2016-12-01

    Full Text Available O presente artigo busca derivar, a partir da Dialética do Senhor e do Escravo, da Fenomenologia do Espírito de Hegel, a sociologia moderna enquanto ciência essencialmente humana. Assim, a partir do conceito de intersubjetividade que Hegel desenvolve através de sua filosofia do espírito, pretende-se analisar os fundamentos filosóficos dos pensamentos sociológicos de Karl Marx e de Max Weber. Conclui-se, portanto, que tanto o viés revolucionário do Manifesto Comunista, quanto o viés conservador da Ética Protestante, partem, fundamentalmente, do legado filosófico hegeliano.

  10. Os 4Ps do composto de marketing na literatura de Ciência da Informação

    Directory of Open Access Journals (Sweden)

    Sueli Angelica Do Amaral

    Full Text Available Analisa 60 documentos sobre os 4Ps do composto de marketing em unidades de informação da literatura de Ciência dei Informação no período de 1975 a 1995, para conhecer quantos e quais autores escreveram sobre o tema, qual o pioneiro, quem foi o pioneiro a propor adição de Ps. Apresenta a cronologia dos documentos estudados e discute as 4Ps do composto de marketing. Propõe a adoção da mais completa proposta analisada como forma de garantir o futuro das unidades de informação.

  11. 40 CFR 60.4210 - What are my compliance requirements if I am a stationary CI internal combustion engine manufacturer?

    Science.gov (United States)

    2010-07-01

    ... I am a stationary CI internal combustion engine manufacturer? 60.4210 Section 60.4210 Protection of... CI internal combustion engine manufacturer? (a) Stationary CI internal combustion engine... certified to the standards in 40 CFR part 1039. (b) Stationary CI internal combustion engine manufacturers...

  12. A imagem da ciência: folheando um livro didático The image of science: leafing through a textbook

    Directory of Open Access Journals (Sweden)

    Elizabeth Macedo

    2004-04-01

    Full Text Available O texto analisa livros didáticos de ciências, centrando-se nas imagens apresentadas nesses dispositivos escolares. Num primeiro momento, apresenta indícios que permitem fazer uma leitura das tradições hegemônicas nos currículos, tendo como contraponto outros sistemas referenciais. Com base em teóricos pós-coloniais, procura mostrar como as imagens corporificam estratégias de omissão e marginalização culturais. Num segundo momento, analisa os modos de endereçamento presentes nos livros: os modelos de ciência e de prática pedagógica apresentados.This text analyzes Science textbooks focusing on the images they present. Using other systems of interpretation as a counterpoint, it begins by stressing the evidence of the hegemonic traditions in school curricula they contain. Based on post-colonial authors, it tries to show how these images embody strategies of cultural omission and marginalization. Finally, it explores the modes of addressing inscribed in such books and the models of Science and pedagogical practice they convey.

  13. À PARTE: As Ciências Sociais no Brasil - trajetória, história e institucionalização

    Directory of Open Access Journals (Sweden)

    José Segatto

    2012-04-01

    Full Text Available

    A trajetória do pensamento social no Brasil remonta à segunda metade do século XIX e envolve muitas correntes, linhagens e famílias intelectuais que enformam as Ciências Sociais no Brasil. Por isso, há controvérsias quanto à fundação das Ciências Sociais, considerada, de um lado, por meio da trajetória histórica, e, de outro, pela institucionalização do trabalho científico. O debate ganha complexidade quando são considerados os marcos fundadores, as características, o significado e as implicações dessa institucionalização que, longe de esclarecer a questão, cria novos problemas para o entendimento e avaliação do processo. Rediscutir as circunstâncias histórico-sociais e as configurações intelectuais de sua fundação e desenvolvimento, entendemos ser pertinente e necessário, sendo esse o propósito deste artigo.

  14. Commercial mitigation techniques used in remediating a 2200 pCi/L public building

    International Nuclear Information System (INIS)

    Davidson, J.G.

    1990-01-01

    This paper reports on commercial mitigation techniques used in remediating a 2200 pCi/L public building. In March of 1989 EPA and Pa. DER officials were amazed to discover a school in Pennsylvania with levels in its library of 2200 pCi/L. The library was a 30 year old, three story slab-on-grade structure more like a commercial building than a typical school structure. It had three separate and complex HVAC systems. Initial diagnostics indicated radon levels under the slab at over 80,000 pCi/L. Further investigations revealed major entry routes and a HVAC system terribly out of balance. Remediation consisted of installing a complex sub-slab depressurization system with an exterior commercial fan unit, major entry route sealing, and working closely with a mechanical contractor to bring the HVAC systems back into balance. Initial post remediation testing showed a 99% drop in radon levels. Refinements to the system are still in progress

  15. The functional significance of cortical reorganization and the parallel development of CI therapy

    Directory of Open Access Journals (Sweden)

    Edward eTaub

    2014-06-01

    Full Text Available For the 19th and the better part of the 20th centuries two correlative beliefs were strongly held by almost all neuroscientists and practitioners in the field of neurorehabilitation. The first was that after maturity the adult CNS was hardwired and fixed, and second that in the chronic phase after CNS injury no substantial recovery of function could take place no matter what intervention was employed. However, in the last part of the 20th century evidence began to accumulate that neither belief was correct. First, in the 1960s and 1970s, in research with primates given a surgical abolition of somatic sensation from a single forelimb, which rendered the extremity useless, it was found that behavioral techniques could convert the limb into an extremity that could be used extensively. Beginning in the late 1980s, the techniques employed with deafferented monkeys were translated into a rehabilitation treatment, termed Constraint Induced Movement therapy or CI therapy, for substantially improving the motor deficit of the upper and lower extremities in the chronic phase after stroke. CI therapy has been applied successfully to other types of damage to the CNS such as traumatic brain injury, cerebral palsy, multiple sclerosis, and spinal cord injury, and it has also been used to improve function in focal hand dystonia and for aphasia after stroke. As this work was proceeding, it was being shown during the 1980s and 1990s that sustained modulation of afferent input could alter the structure of the CNS and that this topographic reorganization could have relevance to the function of the individual. The alteration in these once fundamental beliefs has given rise to important recent developments in neuroscience and neurorehabilitation and holds promise for further increasing our understanding of CNS function and extending the boundaries of what is possible in neurorehabilitation.

  16. Analiza przyczyn zawilgocenia podziemnej części budynku „Dworek” uniwersytetu rolniczego w Krakowie

    Directory of Open Access Journals (Sweden)

    Andrzej Gruchot

    2014-04-01

    Full Text Available W pracy przedstawiono ocenę przyczyn zawilgocenia ścian piwnic budynku „Dworek” Uniwersytetu Rolniczego w Krakowie oraz zaproponowano środki zaradcze. Zakres prac badawczych obejmował badania terenowe mające na celu rozpoznanie konstrukcji fundamentów oraz badania laboratoryjne właściwości geotechnicznych gruntów podłoża. Stwierdzono, że występujące zawilgocenia ścian piwnic, jak również złuszczenia tynku są następstwem niestarannego wykonania izolacji przeciwwilogociowej, a główną przyczyną ich zawilgocenia jest woda opadowa. Jako rozwiązanie zaproponowano wykonanie przeciwwilgociowej izolacji poziomej oraz szczelne wybrukowanie powierzchni terenu przed ścianą pomieszczeń w celu odsunięcia strefy infiltracji wód opadowych.

  17. Kidnapping Detection and Recognition in Previous Unknown Environment

    Directory of Open Access Journals (Sweden)

    Yang Tian

    2017-01-01

    Full Text Available An unaware event referred to as kidnapping makes the estimation result of localization incorrect. In a previous unknown environment, incorrect localization result causes incorrect mapping result in Simultaneous Localization and Mapping (SLAM by kidnapping. In this situation, the explored area and unexplored area are divided to make the kidnapping recovery difficult. To provide sufficient information on kidnapping, a framework to judge whether kidnapping has occurred and to identify the type of kidnapping with filter-based SLAM is proposed. The framework is called double kidnapping detection and recognition (DKDR by performing two checks before and after the “update” process with different metrics in real time. To explain one of the principles of DKDR, we describe a property of filter-based SLAM that corrects the mapping result of the environment using the current observations after the “update” process. Two classical filter-based SLAM algorithms, Extend Kalman Filter (EKF SLAM and Particle Filter (PF SLAM, are modified to show that DKDR can be simply and widely applied in existing filter-based SLAM algorithms. Furthermore, a technique to determine the adapted thresholds of metrics in real time without previous data is presented. Both simulated and experimental results demonstrate the validity and accuracy of the proposed method.

  18. Cooperação Internacional em Ciência e Tecnologia: Refletindo Conceitos e Questões Contemporâneas

    Directory of Open Access Journals (Sweden)

    Maria Clotilde Meirelles Ribeiro

    2014-12-01

    Full Text Available O artigo discute a cooperação internacional para o desenvolvimento no eixo da Ciência e Tecnologia (C&T, analisando questões cruciais contemporâneas e questões brasileiras específicas. Partindo de contribuições de relevantes autores, o trabalho focaliza os conceitos centrais de ciência, tecnologia e cooperação internacional em C&T, com distintas visões de especialistas em diferentes períodos. Na sequência, aborda tipologias da cooperação internacional, introduzindo uma reflexão sobre a técnica e a natureza humana, e sobre distinções entre “técnica” e “tecnologia”, bem como especificidades dos vetores da cooperação científico-tecnológica e da cooperação técnica. Prosseguindo, o artigo traz um breve histórico da trajetória da cooperação internacional em C&T, notadamente nos momentos demarcados pela Guerra Fria, aporta exemplos concretos e debate dilemas, oportunidades, riscos e desafios, bem como a realidade do Brasil diante deste instrumento da política externa dos governos.

  19. Formação de professores de ciências sociais/sociologia: subsídios para o debate

    Directory of Open Access Journals (Sweden)

    Leomir Souza Costa

    2015-12-01

    Full Text Available http://dx.doi.org/10.5007/1806-5023.2015v12n2p187 Este trabalho busca refletir sobre o tema da formação inicial de professores de Ciências Sociais/Sociologia. Em um primeiro momento, analisa brevemente os modelos formativos das licenciaturas em Ciências Sociais, na tentativa de extrair as concepções sobre a formação do professor de Sociologia da escola média, presentes em muitas instituições de ensino superior. Em seguida, retoma a discussão em torno dos binômios licenciatura versus bacharelado, ensino versus pesquisa, na medida em que a dicotomia “ser professor/ser pesquisador”, presente nos percursos formativos adotados por muitas universidades, evidencia um desequilíbrio na relação entre teoria e prática.  Por fim, aponta o estágio curricular dos cursos de licenciatura como um espaço privilegiado de encontro entre teoria e prática, e o Programa Institucional de Bolsas de Iniciação à Docência (PIBID como uma oportunidade de conexão entre o processo de formação inicial na universidade e a prática profissional docente.

  20. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

    CSIR Research Space (South Africa)

    Van Greunen, DG

    2017-02-01

    Full Text Available A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug...

  1. Bevacizumab plus chemotherapy in elderly patients with previously untreated metastatic colorectal cancer: single center experience

    International Nuclear Information System (INIS)

    Ocvirk, Janja; Moltara, Maja Ebert; Mesti, Tanja; Boc, Marko; Rebersek, Martina; Volk, Neva; Benedik, Jernej; Hlebanja, Zvezdana

    2016-01-01

    Metastatic colorectal cancer (mCRC) is mainly a disease of elderly, however, geriatric population is underrepresented in clinical trials. Patient registries represent a tool to assess and follow treatment outcomes in this patient population. The aim of the study was with the help of the patients’ register to determine the safety and efficacy of bevacizumab plus chemotherapy in elderly patients who had previously untreated metastatic colorectal cancer. The registry of patients with mCRC was designed to prospectively evaluate the safety and efficacy of bevacizumab-containing chemotherapy as well as selection of patients in routine clinical practice. Patient baseline clinical characteristics, pre-specified bevacizumab-related adverse events, and efficacy data were collected, evaluated and compared according to the age categories. Between January 2008 and December 2010, 210 patients with mCRC (median age 63, male 61.4%) started bevacizumab-containing therapy in the 1 st line setting. Majority of the 210 patients received irinotecan-based chemotherapy (68%) as 1 st line treatment and 105 patients (50%) received bevacizumab maintenance therapy. Elderly (≥ 70 years) patients presented 22.9% of all patients and they had worse performance status (PS 1/2, 62.4%) than patients in < 70 years group (PS 1/2, 35.8%). Difference in disease control rate was mainly due to inability to assess response in elderly group (64.6% in elderly and 77.8% in < 70 years group, p = 0.066). The median progression free survival was 10.2 (95% CI, 6.7–16.2) and 11.3 (95% CI, 10.2–12.6) months in elderly and < 70 years group, respectively (p = 0.58). The median overall survival was 18.5 (95% CI, 12.4–28.9) and 27.4 (95% CI, 22.7–31.9) months for elderly and < 70 years group, respectively (p = 0.03). Three-year survival rate was 26% and 37.6% in elderly vs. < 70 years group (p = 0.03). Overall rates of bevacizumab-related adverse events were similar in both groups: proteinuria 21

  2. Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

    Science.gov (United States)

    2016-10-01

    occasions, magnetic resonance imaging ( MRI ), diffusion tensor imaging (DTI), and functional MRI (fMRI) of the brain will be carried out to determine changes...to which types of neuroplasticity-inducing pharmacological agents, when combined with CI therapy, are most likely to yield a superior treatment...were negotiated with the Birmingham VAMC, Denver VAMC, and Richmond VAMC. • The option of collecting MRI data using a 1.5T scanner was added for

  3. Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery

    NARCIS (Netherlands)

    Schippers, E.F.; Berbée, J.F.P.; Disseldorp, I.M. van; Versteegh, M.I.M.; Havekes, L.M.; Rensen, P.C.N.; Dissel, J.T. van

    2008-01-01

    Objective: Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing cardiopulmonary bypass surgery (CPB) and experiencing endotoxemia during reperfusion whether plasma apoCI levels correlate with the

  4. LHV predication models and LHV effect on the performance of CI engine running with biodiesel blends

    International Nuclear Information System (INIS)

    Tesfa, B.; Gu, F.; Mishra, R.; Ball, A.D.

    2013-01-01

    Highlights: • Lower heating values of neat biodiesel and its blends were measured experimentally. • Lower heating value prediction models were developed based on the density and viscosity values of the fuel. • The predication models were validated by measured values and previous models. • The prediction models were used to predict the lower heating value of 24 biodiesel feedstock types produced globally. • The effects of lower heating vale on brake specific fuel consumption and thermal efficiency were investigated. - Abstract: The heating value of fuel is one of its most important physical properties, and is used for the design and numerical simulation of combustion processes within internal combustion (IC) engines. Recently, there has been a significant increase in the use of dual fuel and blended fuels in compression ignition (CI) engines. Most of the blended fuels include biodiesel as one of the constituents and hence the objective of this study is to investigate the effect of biodiesel content to lower heating value (LHV) and to develop new LHV prediction models that correlate the LHV with biodiesel fraction, density and viscosity. Furthermore, this study also investigated the effects of the LHV on CI engines performance parameters experimentally. To achieve the above mentioned objectives density, viscosity and LHV of rapeseed oil biodiesel, corn oil biodiesel and waste oil biodiesel at different blend fraction values (B0, B5, B10, B20, B50, B75, and B100, where ‘B5’ denotes a blend of 5% biodiesel and 95% mineral diesel, etc.) were measured as per EN ISO 3675:1998, EN ISO 3104:1996 and DIN 51900 standards. The engine experimental work was conducted on a four-cylinder, four-stroke, direct injection (DI) and turbocharged diesel engine by using rapeseed oil and normal diesel blends. Based on the experimental results, models were developed which have the capability to predict the LHV corresponding to different fractions, densities and viscosities of

  5. Palenie papierosów w ciąży = Cigarette smoking in pregnancy

    Directory of Open Access Journals (Sweden)

    Agnieszka Konstancja Pawłowska-Muc

    2016-01-01

    4 Doctoral Candidate at the Department and Clinic of Gynaecology and Gynaecological Endocrinology, School of Health Studies, Medical University of Lublin, Al. Racławickie 23   Adres do korespondencji: mgr piel. Agnieszka Konstancja Pawłowska-Muc Ośrodek Kształcenia Podyplomowego Pielęgniarek i Położnych Radomski Szpital Specjalistyczny im. dr Tytusa Chałubińskiego w Radomiu, ul. Lekarska 4 tel. 48  3615616; fax: 48 3615437 e-mail: agmich@vp.pl   Streszczenie Wprowadzenie. Palenie papierosów jest dużym problemem zdrowotnym i społeczno – ekonomicznym. Stanowi zagrożenie dla rozrodu, przebiegu ciąży i zdrowia dziecka. Cel pracy. Ukazanie problemu palenia papierosów przez kobiety ciężarne na podstawie przeglądu piśmiennictwa.             Skrócony opis stanu wiedzy. W opracowaniu przedstawiono epidemiologię i skalę problemu oraz konsekwencje palenia w okresie ciąży, z uwzględnieniem podziału na przebieg ciąży i zdrowie dziecka. Omówiono też świadomość kobiet odnośnie negatywnych skutków takich zachowań. Podsumowanie. Z przeglądu piśmiennictwa wynika, że palenie papierosów przez kobiety ciężarne nie należy do rzadkości. Skala problemu nie jest łatwa do oceny, gdyż wiele z nich po prostu nie przyznaje się do tego. Negatywne konsekwencje palenia w ciąży są dość liczne i dotyczą zarówno jej przebiegu, jak i stanu noworodka oraz zdrowia dziecka w późniejszym okresie życia. Istnieje potrzeba kształtowania postaw antynikotynowych, zwłaszcza wśród dziewcząt i kobiet w wieku rozrodczym.   Słowa kluczowe: kobieta ciężarna, palenie papierosów w ciąży.                                                                   Summary Introduction. Smoking cigarettes is a major health and social-economical problem. It poses a threat to reproduction, parturition and the health of the baby. Aim. Illustrating the problem of smoking cigarettes by

  6. Ocena zdolności do kontynuowania działalności polskich spółek giełdowych w czasie kryzysu za pomocą modeli wielowymiarowej analizy dyskryminacyjnej

    Directory of Open Access Journals (Sweden)

    Paweł Kopczyński

    2017-06-01

    Full Text Available Ocena zdolności do kontynuowania działalności polskich spółek giełdowych w czasie kryzysu za pomocą modeli wielowymiarowej analizy dyskryminacyjnej The Global Financial Crisis, which began in 2007, had a huge influence on the situation on world stock markets. The behavior of investors is often affected by various factors which can impact their investment decisions. As they do not always act rationally, have a tendency to overreact and cannot remove all emo-tional components from their decision-making process, it may be difficult to explain their behavior and investment decisions during the crisis, especially those concerning the sale of shares. The huge drop in share prices on world stock markets was visible in the early stages of the crisis, but it probably was not justified by actual deterioration of the financial situation of listed companies. The Global Financial Crisis triggered a wave of panic selling of shares on the Warsaw Stock Exchange (WSE. As the fluctuations in share prices do not always reflect the real economic situation of the companies, it is worth to examine whether the financial standing of companies listed on WSE actually deteriorated and whether the number of companies facing bankruptcy grew during the 2007 Crisis. The main purpose of this article is to evalu-ate the influence of the recent financial crisis on the financial situation and performance of Polish listed companies. Eight multiple discriminant analysis models were utilized to evaluate the real changes in the financial situation of Polish listed companies during the crisis (years 2006-2011. The aforementioned models enable prediction of corporate bankruptcy and measurement of financial health of companies. Theoretically, the number of companies facing bankruptcy should increase in time of crisis. As many as 175 joint-stock companies listed on the regulated market of the WSE were covered by the study. Their financial data were extracted from the Notoria

  7. A universidade corrupta: o jeitinho brasileiro de se fazer ciência

    Directory of Open Access Journals (Sweden)

    Ivan Martins Fontes Leichsenring

    2013-12-01

    Full Text Available Antes do advento do Sistema Qualis, a pesquisa enviesada sempre pareceu ser uma via fácil na obtenção de financiamento, reconhecimento e privatização da máquina universitária nas mãos de poucos grupos científicos, como há muito, por exemplo, tem nos demonstrado a área de Medicina e suas relações um tanto discutíveis com a indústria farmacêutica. Neste estudo, após um breve levantamento histórico-comparativo com a situação alemã do Entre Guerras, tecemos algumas críticas sobre a atual produção científica brasileira nas Ciências Humanas e ao atrelamento de nossas universidades públicas aos modelos internacionais e cientificistas de produtividade. E, também, tentamos debater como a corrupção científica tem se construído e fortalecido por causa da enorme pressão do “publicar ou perecer” e da adoção do Sistema Qualis, que têm induzido nossos cientistas a optar por consagrar temas já anteriormente pré-consagrados, evitando assim a crítica, anulando possíveis questionamentos, estimulando a publicação de “artigos-placebo” e impedindo, em última análise, o desenvolvimento científico e tecnológico do país. Abstract: Before the advent of the Qualis System, skewed research always seemed to be an easy way to obtain funding, recognition and privatization of the university machine in the hands of a few scientific groups, as for a long while, the area of medicine and its somewhat controversial relationships with the pharmaceutical industry has shown us. In this study, after a brief comparative-historical survey with the German situation of interwar period, some criticism have been weaved about the current Brazilian scientific production in the humanities and the bundling of our public universities to international and scientificist productivity models. A discussion has also been tried on how scientific corruption has built and strengthened because of the enormous pressure of 'publishing or perishing' and

  8. Ciência, saúde e desenvolvimento: a doença de Chagas no Brasil (1943-1962

    Directory of Open Access Journals (Sweden)

    Simone Petraglia Kropf

    2005-12-01

    Full Text Available Analisa o processo histórico de construção da doença de Chagas, descoberta em 1909, como entidade médica específica e problema de saúde pública no Brasil, focalizando a atuação de um posto de pesquisa do Instituto Oswaldo Cruz, criado em 1943, no interior de Minas Gerais. Sugere que o trabalho realizado neste posto proporcionou um consenso básico para que a doença alcançasse legitimidade científica e social, e que os significados atribuídos à doença neste processo estiveram diretamente referidos aos debates sobre as relações entre ciência, saúde e desenvolvimento, no contexto da Segunda Guerra Mundial.

  9. 2018_extent_CI_data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Full resolution (300m), weekly MERIS data were obtained over the contiguous United States for 2008 through 2011. Seven day composite images were created by retaining...

  10. Direct Simple Shear Test Data Analysis using Jupyter Notebooks on DesignSafe-CI

    Science.gov (United States)

    Eslami, M.; Esteva, M.; Brandenberg, S. J.

    2017-12-01

    Due to the large number of files and their complex structure, managing data generated during natural hazards experiments requires scalable and specialized tools. DesignSafe-CI (https://www.designsafe-ci.org/) is a web-based research platform that provides computational tools to analyze, curate, and publish critical data for natural hazards research making it understandable and reusable. We present a use case from a series of Direct Simple Shear (DSS) experiments in which we used DS-CI to post-process, visualize, publish, and enable further analysis of the data. Current practice in geotechnical design against earthquakes relies on the soil's plasticity index (PI) to assess liquefaction susceptibility, and cyclic softening triggering procedures, although, quite divergent recommendations on recommended levels of plasticity can be found in the literature for these purposes. A series of cyclic and monotonic direct simple shear experiments was conducted on three low-plasticity fine-grained mixtures at the same plasticity index to examine the effectiveness of the PI in characterization of these types of materials. Results revealed that plasticity index is an insufficient indicator of the cyclic behavior of low-plasticity fine-grained soils, and corrections for pore fluid chemistry and clay minerology may be necessary for future liquefaction susceptibility and cyclic softening assessment procedures. Each monotonic, or cyclic experiment contains two stages; consolidation and shear, which include time series of load, displacement, and corresponding stresses and strains, as well as equivalent excess pore-water pressure. Using the DS-CI curation pipeline we categorized the data to display and describe the experiment's structure and files corresponding to each stage of the experiments. Two separate notebooks in Python 3 were created using the Jupyter application available in DS-CI. A data plotter aids visualizing the experimental data in relation to the sensor from which it was

  11. Notas para uma aproximação entre o neodarwinismo e as ciências sociais Notes on an approximation between neo-Darwinism and the social sciences

    Directory of Open Access Journals (Sweden)

    Ricardo Waizbort

    2005-08-01

    Full Text Available O objetivo deste trabalho é apresentar a psicologia evolutiva, uma ciência que procura compreender a mente humana (cultural, social, histórica como produto de processos biológicos e evolutivos, e a memética, uma teoria ainda incipiente que pretende tratar a informação cultural e as próprias tradições como complexos de idéias, que usam os cérebros humanos para se reproduzirem. Essas duas novas abordagens pretendem contribuir para integrar as ciências biológicas e as ciências sociais.Evolutionary psychology is a science that endeavors to understand the human mind (cultural, social, historical as a product of biological and evolutionary processes. Memetics is an incipient theory that views cultural information and traditions as sets of ideas that reproduce themselves within the human brain. The article introduces these two new approaches and explores how they intend to contribute to the integration of the biological and social sciences.

  12. Inteligência Artificial, Tecnologias Informacionais E Seus Possíveis Impactos Sobre As Ciências Sociais

    OpenAIRE

    Dwyer T.

    2001-01-01

    Este artigo analisa algumas possibilidades de transformação das Ciências Sociais e, de maneira mais específica, na Sociologia, levantadas a partir do desenvolvimento e uso, nessas ciências, de tecnologias informacionais. Nas sociedades contemporâneas o aprofundamento do uso destas novas tecnologias pode trazer importantes conseqüências para as Ciências Sociais afetando, potencialmente, o ensino, a pesquisa e a construção de teoria. No Brasil podemos ver que um número crescente de informações ...

  13. Prognozowanie i ujmowanie przychodóww przedsiębiorstwie postawionymw stan upadłości likwidacyjnej

    OpenAIRE

    Janusz Czerny

    2010-01-01

    W upadłości likwidacyjnej przedsiębiorstw mamy do czynienia z dwoma stru-mieniami przychodów, a mianowicie z przychodami dotyczącymi zbycia przedsię-biorstwa lub jego składników majątku oraz z przychodami związanymi z ewentual-nym kontynuowaniem działalności: Przychody ze sprzedaży przedsiębiorstwa powinny być prognozowane głównie na podstawie informacji płynących z systemu rachunkowości, co stanowi tzw. sta-tyczny aspekt upadłości, natomiast jej aspekt dynamiczny jest związany z zakre-sem...

  14. Analysis of previous perceptual and motor experience in breaststroke kick learning

    Directory of Open Access Journals (Sweden)

    Ried Bettina

    2015-12-01

    Full Text Available One of the variables that influence motor learning is the learner’s previous experience, which may provide perceptual and motor elements to be transferred to a novel motor skill. For swimming skills, several motor experiences may prove effective. Purpose. The aim was to analyse the influence of previous experience in playing in water, swimming lessons, and music or dance lessons on learning the breaststroke kick. Methods. The study involved 39 Physical Education students possessing basic swimming skills, but not the breaststroke, who performed 400 acquisition trials followed by 50 retention and 50 transfer trials, during which stroke index as well as rhythmic and spatial configuration indices were mapped, and answered a yes/no questionnaire regarding previous experience. Data were analysed by ANOVA (p = 0.05 and the effect size (Cohen’s d ≥0.8 indicating large effect size. Results. The whole sample improved their stroke index and spatial configuration index, but not their rhythmic configuration index. Although differences between groups were not significant, two types of experience showed large practical effects on learning: childhood water playing experience only showed major practically relevant positive effects, and no experience in any of the three fields hampered the learning process. Conclusions. The results point towards diverse impact of previous experience regarding rhythmic activities, swimming lessons, and especially with playing in water during childhood, on learning the breaststroke kick.

  15. A crise de eficiência da escola para além de seus muros: a influência dos capitais social, cultural e econômico no desempenho escolar em ciências

    Directory of Open Access Journals (Sweden)

    Eveline Borges Vilela-Ribeiro

    Full Text Available Resumo: Avaliamos de que modo os capitais social, cultural e econômico dos estudantes do ensino secundário afetam, em escala global, o seu desempenho em ciências e teorizamos de que maneira esses resultados se relacionam à crise educacional tal como predita o modelo neoliberal. Utilizamos os resultados de ciências das avaliações realizadas pelo Programme for International Student Assessment (PISA no ano de 2009 por diversos países e os relacionamos com índices de capitais cultural, social e econômico criados a partir de dados internacionais. Analisamos, no programa Statistica, de que maneira cada um dos capitais se relaciona ao desempenho dos países em ciências. Construímos, para isso, figuras que relacionam os capitais ao seu desempenho em ciências. Os resultados mostram que o capital econômico é fundamental ao bom desempenho em ciências; apenas o atrelamento entre todos os capitais (econômicos, sociais e culturais é que pode fornecer, entretanto, uma explicação mais completa para os resultados.

  16. Desempenho acadêmico em métodos quantitativos nos cursos de Ciências Contábeis

    Directory of Open Access Journals (Sweden)

    Manoel Raimundo Santana Farias

    2015-08-01

    Full Text Available Este estudo investigou variáveis que explicam o desempenho acadêmico (academic achievement nas disciplinas de métodos quantitativos no curso de ciências contábeis. Realizou-se uma pesquisa empírica na Universidade Federal do Pará com objetivo de encontrar proxies associadas à variável dependente desempenho acadêmico. Assim, com a finalidade de ratificar os achados desta pesquisa, foi realizado teste estatístico de análise de regressão por meio do software SPSS®. A análise inferencial conjecturou oito variáveis que explicariam o desempenho dos discentes, quais sejam: desempenho anterior em matemática e/ou estatística, índice de participação do discente na realização das disciplinas, turno de estudo, idade, gênero, estado civil, possuir ou não renda e origem escolar. Após a realização da análise de regressão com essas variáveis, o modelo mais adequado para representação do desempenho dos discentes foi o que considerou apenas as seguintes variáveis: desempenho anterior em matemática e/ ou estatística, índice de participação do discente na realização das disciplinas, o turno de estudo e a idade, as quais apresentaram significância estatística. Esses resultados ratificam que características pessoais determinam o desempenho de discentes de ciências contábeis, como afirmado por Santos (2012, referenciada neste estudo. Futuras pesquisas podem ratificar as variáveis aqui trabalhadas e expandir tal estudo a fim de obter um modelo mais representativo sobre o desempenho dos discentes em métodos quantitativos nos cursos de ciências contábeis.

  17. A questão da universidade e da formação em ciências sociais

    Directory of Open Access Journals (Sweden)

    Sylvia Gemignani Garcia

    2000-05-01

    Full Text Available A análise histórica dos processos sociais e intelectuais que caracterizam a formação cultural e científica na modernidade contemporânea permite a reconstrução de questões culturais e educacionais que se fazem constantemente presentes hoje no dia-a-dia da vida universitária na forma de problemas acadêmicos e administrativos. Situada na intersecção das áreas de história intelectual, sociologia da ciência e das instituições científicas e sociologia da educação e da cultura, essa perspectiva de investigação aborda, primeiro, os amplos processos institucionais nas esferas da política, da economia e da cultura que situam a questão contemporânea da universidade e da formação em ciências sociais; em seguida, expõe alguns aspectos centrais do debate sociológico acerca da natureza da disciplina e do perfil da formação em ciência social; e, finalmente, discute certos pressupostos e categorias básicas das atuais propostas de reforma universitária.The historical analysis of the social and intellectual processes that characterise the cultural and scientific education in contemporary modernity allows for the reconstruction of cultural and educational questions, which are perceived as academic and administrative problems in our daily lives at the university. The approach adopted in this paper is situated at the intersection between intellectual history, the sociology of science and scientific institutions and the sociology of education and culture. It discusses, firstly, the wide institutional processes in the political, economic and cultural spheres that circumscribe the contemporary questions of the university and the education in social sciences; secondly, it analyses some of the central aspects of the sociological debate on the nature of the discipline and the profile of the education in social sciences; finally it looks at a few premises and basic categories of the present proposals for the reform of the university.

  18. As mídias sociais de olho na CI na perspectiva da disseminação da informação

    Directory of Open Access Journals (Sweden)

    Aline Poggi Lins Lima

    2014-04-01

    Full Text Available http://dx.doi.org/10.5007/1518-2924.2014v19n39p113 Esta comunicação apresenta resultados obtidos em pesquisa-dissertação desenvolvida no Programa de Pós-Graduação em Ciência da Informação da Universidade Federal da Paraíba. A pesquisa abordou o Blog de olho na CI na perspectiva das mídias sociais da rede Internet como recursos capazes de desenvolver Redes Sociais na Internet (RSI e meio de disseminação de informação. O objetivo foi analisar como se processa a disseminação da informação de interesse para os profissionais da informação através destas mídias sociais, a partir de uma da pesquisa descritiva, utilizou como instrumentos de coleta dos dados as técnicas da observação participante e o diário de campo. A análise dos dados foi documental, relacionada ao contexto da pesquisa na internet. Diante da pesquisa, observou-se que se pode comprovar o crescimento do blog De olho na CI na rede internet e entre profissionais da informação, crescimento que se estende a outras mídias sociais, Twitter e Facebook.

  19. Preferowanie podmiotów publicznych w niektórych rodzajach działalności gospodarczej

    OpenAIRE

    Sylwestrzak, Dorota

    2015-01-01

    Ustawodawca stwarza warunki zapewniające niedyskryminacyjne tratowanie podmiotów publicznych i prywatnych, ale zdarza się różnicowanie podmiotów, podyktowane zasadniczo przesłanką interesu publicznego i koniecznością ochrony wartości konstytucyjnych, Faworyzowanie podmiotów publicznych przejawia się głównie w zakresie stwarzania ułatwień w podejmowaniu działalności gospodarczej, w wyborze formy organizacyjno-prawnej, w której działalność gospodarcza może być prowadzona,...

  20. Full Core Multiphysics Simulation with Offline Mesh Deformation

    Energy Technology Data Exchange (ETDEWEB)

    Merzari, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Shemon, E. R. [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Thomas, J. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Obabko, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States); Solberg, Jerome [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ferencz, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Whitesides, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-12-21

    In this report, building on previous reports issued in FY13 we describe our continued efforts to integrate thermal/hydraulics, neutronics, and structural mechanics modeling codes to perform coupled analysis of a representative fast sodium-cooled reactor core. The focus of the present report is a full core simulation with off-line mesh deformation.

  1. Spacecraft COst REduction Team (SCORE): TQM/CI on a massive scale

    Science.gov (United States)

    Bullard, Jerry D.

    1992-01-01

    The business of building satellites and space systems has matured. Few missions require, or can afford, excellent performance at any price. The new paradigm is doing more with less, providing quality systems at lower cost--in other words, doing our job 'Faster-Better-Cheaper.' The TRW Spacecraft COst REduction (SCORE) initiative was launched in 1990 by Daniel S. Goldin, then general manager of TRW's Space & Technology Group. The SCORE mission is to apply continuous improvement (CI) techniques to effect major reductions in the cost (our primary goal) and span time (as a corollary) required for the production of spacecraft. SCORE is a multi-year initiative that is having a profound effect on both the procedural and the cultural aspects of how we do business. The objectives of this initiative are being realized. The focus of this paper is not on the results of SCORE per se, but rather on the things we have leaned about how to do continuous improvement on a massive scale, with multilevel (hierarchical) CI teams. The following sections summarize the chronology of the SCORE initiative, from team formation to development of the year-end report for 1991. Lessons learned, the core of this presentation, are discussed--with particular focus on the unique aspects of SCORE. The SCORE initiative is continuing and, as a part of our evolving culture, will never end. It has resulted in profound insights into the way we do work and (the topic at hand) how to do CI for large and complex multidisciplinary development activities.

  2. O ser que envelhece: técnica, ciência e saber The being that ages: technique, science and knowledge

    Directory of Open Access Journals (Sweden)

    Shirley Donizete Prado

    2007-03-01

    Full Text Available Abordamos a Gerontologia, que se pretende ciência do envelhecimento. A partir de Bachelard e Canguilhem, discutimos as perspectivas da Gerontologia como ciência naquilo que se refere à Fisiologia do Envelhecimento, da Genética do Envelhecimento ou da Biogerontologia e como um conjunto de técnicas de cura, de alívio da dor, de ação sobre a vida do ser que envelhece através da Geriatria, da Psicogeriatria, da Enfermagem Geriátrica, do Serviço Social, por exemplo. A partir do pensamento de Foucault, consideramos que a Gerontologia inclui os saberes sobre este ser único que pensa sobre si mesmo e sobre suas próprias representações por meio da Antropologia, da Psicanálise, entre outras. Quanto a ter por objeto o envelhecimento, entendemos que se trata de um projeto absolutamente ambicioso, que praticamente coincide com as Ciências Humanas e da Vida quando tematizam a juventude e o envelhecer. Hoje, parece-nos, a Gerontologia corresponde a um conjunto de ciências, técnicas e saberes voltados, principalmente, para esse ainda nebuloso domínio que é a velhice.We address Gerontology in its perception as the science of aging. Based on Bachelard and Canguilhem, we discuss the perspectives of Gerontology as science in terms of Aging Philosophy, Aging Genetics or Bio-Gerontology, and as a set of techniques for cure such as pain relief, action on life of the being that ages through Geriatrics, Psycho-geriatrics, Geriatric Nursing and Social Service. Based on Foucault, we consider that Gerontology comprises all knowledge on that unique being who thinks about himself and about his own representations, through Anthropology, Psychoanalysis, and so on. As to the fact that aging is the object , we see this as an ambitious project, which almost coincides with Human Sciences and Life when these deal with youth and old age. Gerontology is today a set of sciences, techniques and knowledge, mainly concerned with the still indefinite domain of old age.

  3. Ciência Lingüística: da origem saussureana ao percurso sociolingüístico

    Directory of Open Access Journals (Sweden)

    Solyany Soares Salgado

    2009-09-01

    Full Text Available

    Este artigo apresenta algumas considerações sobre as diretrizes tomadas pela ciência Lingüística na tentativa de oferecer um melhor aparato teórico para a compreensão dos fenômenos lingüísticos. Neste trabalho, as propostas teóricas originadas de reflexões feitas por autores como Saussure, Bakhtin, Chomsky e Labov são levadas em consideração para mostrar, entre outras coisas, que os lingüistas estão vendo, cada vez mais, a possibilidade de se trabalhar aspectos em comum de teorias lingüísticas diferentes para melhor explicar o objeto de estudo.

  4. Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review.

    Science.gov (United States)

    Mugambi, Mary N; Musekiwa, Alfred; Lombard, Martani; Young, Taryn; Blaauw, Reneé

    2012-10-04

    Synbiotics, probiotics or prebiotics are being added to infant formula to promote growth and development in infants. Previous reviews (2007 to 2011) on term infants given probiotics or prebiotics focused on prevention of allergic disease and food hypersensitivity. This review focused on growth and clinical outcomes in term infants fed only infant formula containing synbiotics, probiotics or prebiotics. Cochrane methodology was followed using randomized controlled trials (RCTs) which compared term infant formula containing probiotics, prebiotics or synbiotics to conventional infant formula with / without placebo among healthy full term infants. The mean difference (MD) and corresponding 95% confidence intervals (CI) were reported for continuous outcomes, risk ratio (RR) and corresponding 95% CI for dichotomous outcomes. Where appropriate, meta-analysis was performed; heterogeneity was explored using subgroup and sensitivity analyses. If studies were too diverse a narrative synthesis was provided. Three synbiotic studies (N = 475), 10 probiotics studies (N = 933) and 12 prebiotics studies (N = 1563) were included. Synbiotics failed to significantly increase growth in boys and girls. Use of synbiotics increased stool frequency, had no impact on stool consistency, colic, spitting up / regurgitation, crying, restlessness or vomiting. Probiotics in formula also failed to have any significant effect on growth, stool frequency or consistency. Probiotics did not lower the incidence of diarrhoea, colic, spitting up / regurgitation, crying, restlessness or vomiting. Prebiotics in formula did increase weight gain but had no impact on length or head circumference gain. Prebiotics increased stool frequency but had no impact on stool consistency, the incidence of colic, spitting up / regurgitation, crying, restlessness or vomiting. There was no impact of prebiotics on the volume of formula tolerated, infections and gastrointestinal microflora. The quality of evidence was

  5. Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057).

    Science.gov (United States)

    Horn, Leora; Spigel, David R; Vokes, Everett E; Holgado, Esther; Ready, Neal; Steins, Martin; Poddubskaya, Elena; Borghaei, Hossein; Felip, Enriqueta; Paz-Ares, Luis; Pluzanski, Adam; Reckamp, Karen L; Burgio, Marco A; Kohlhäeufl, Martin; Waterhouse, David; Barlesi, Fabrice; Antonia, Scott; Arrieta, Oscar; Fayette, Jérôme; Crinò, Lucio; Rizvi, Naiyer; Reck, Martin; Hellmann, Matthew D; Geese, William J; Li, Ang; Blackwood-Chirchir, Anne; Healey, Diane; Brahmer, Julie; Eberhardt, Wilfried E E

    2017-12-10

    Purpose Nivolumab, a programmed death-1 inhibitor, prolonged overall survival compared with docetaxel in two independent phase III studies in previously treated patients with advanced squamous (CheckMate 017; ClinicalTrials.gov identifier: NCT01642004) or nonsquamous (CheckMate 057; ClinicalTrials.gov identifier: NCT01673867) non-small-cell lung cancer (NSCLC). We report updated results, including a pooled analysis of the two studies. Methods Patients with stage IIIB/IV squamous (N = 272) or nonsquamous (N = 582) NSCLC and disease progression during or after prior platinum-based chemotherapy were randomly assigned 1:1 to nivolumab (3 mg/kg every 2 weeks) or docetaxel (75 mg/m 2 every 3 weeks). Minimum follow-up for survival was 24.2 months. Results Two-year overall survival rates with nivolumab versus docetaxel were 23% (95% CI, 16% to 30%) versus 8% (95% CI, 4% to 13%) in squamous NSCLC and 29% (95% CI, 24% to 34%) versus 16% (95% CI, 12% to 20%) in nonsquamous NSCLC; relative reductions in the risk of death with nivolumab versus docetaxel remained similar to those reported in the primary analyses. Durable responses were observed with nivolumab; 10 (37%) of 27 confirmed responders with squamous NSCLC and 19 (34%) of 56 with nonsquamous NSCLC had ongoing responses after 2 years' minimum follow-up. No patient in either docetaxel group had an ongoing response. In the pooled analysis, the relative reduction in the risk of death with nivolumab versus docetaxel was 28% (hazard ratio, 0.72; 95% CI, 0.62 to 0.84), and rates of treatment-related adverse events were lower with nivolumab than with docetaxel (any grade, 68% v 88%; grade 3 to 4, 10% v 55%). Conclusion Nivolumab provides long-term clinical benefit and a favorable tolerability profile compared with docetaxel in previously treated patients with advanced NSCLC.

  6. Combustion Characteristics of CI Diesel Engine Fuelled With Blends of Jatropha Oil Biodiesel

    Science.gov (United States)

    Singh, Manpreet; Yunus Sheikh, Mohd.; Singh, Dharmendra; Nageswara rao, P.

    2018-03-01

    Jatropha Curcas oil is a non-edible oil which is used for Jatropha biodiesel (JBD) production. Jatropha biodiesel is produced using transesterification technique and it is used as an alternative fuel in CI diesel engine without any hardware modification. Jatropha biodiesel is used in CI diesel engine with various volumetric concentrations (blends) such as JBD5, JBD15, JBD25, JBD35 and JBD45. The combustion parameters such as in-cylinder pressure, rate of pressure rise, net heat release, cumulative heat release, mass fraction burned are analyzed and compared for all blends combustion data with mineral diesel fuel (D100).

  7.  O czynnikach kształtujących systemy rachunkowości i kontroli zarządczej. Krytyczny przegląd badań empirycznych

    Directory of Open Access Journals (Sweden)

    Joanna Dyczkowska

    2015-12-01

    Full Text Available Z punktu widzenia zachodzących zmian ważne staje się pozyskanie wiedzy o systemach rachunkowości i kontroli zarządczej z perspektywy różnych czynników mogących mieć wpływ na ich kształt. Dla nauki istotne jest prowadzenie szeroko zakrojonych długookresowych badań podstawowych w tym zakresie, odnoszących się zarówno do jednostek sektora prywatnego, jak i publicznego, co może jednoznacznie przyczynić się do stworzenia obrazu o aktualnym stanie systemów rachunkowości i kontroli zarządczej oraz kierunkach ich rozwoju. Celem tego artykułu jest uogólnienie wniosków dotyczących wpływu zróżnicowanych czynników na systemy rachunkowości i kontroli zarządczej. Dlatego analizowano cztery obszary: rodzaj stosowanej strategii, kulturę narodową, niepewność otoczenia oraz zintegrowane systemy informacyjne, których wpływy były najczęściej spotykane w literaturze przedmiotu. Jako metodę zasto-sowano krytyczny przegląd opracowań z dziedziny rachunkowości zarządczej, w tym w szczególności wyników badań empirycznych prowadzonych we wskazanych obszarach i opublikowanych na łamach renomowanych czasopism naukowych. Dokonano także systematyki pojęć w odniesieniu do systemów kontroli zarządczej oraz zdefiniowano czynniki rozważane w artykule. W pracy tej przyjęto też trzy tezy, których prawdziwość udowodniono w toku analizy.

  8. Characterisation of the artificial neural network CiPS for cirrus cloud remote sensing with MSG/SEVIRI

    Directory of Open Access Journals (Sweden)

    J. Strandgren

    2017-11-01

    Full Text Available Cirrus clouds remain one of the key uncertainties in atmospheric research. To better understand the properties and physical processes of cirrus clouds, accurate large-scale observations from satellites are required. Artificial neural networks (ANNs have proved to be a useful tool for cirrus cloud remote sensing. Since physics is not modelled explicitly in ANNs, a thorough characterisation of the networks is necessary. In this paper the CiPS (Cirrus Properties from SEVIRI algorithm is characterised using the space-borne lidar CALIOP. CiPS is composed of a set of ANNs for the cirrus cloud detection, opacity identification and the corresponding cloud top height, ice optical thickness and ice water path retrieval from the imager SEVIRI aboard the geostationary Meteosat Second Generation satellites. First, the retrieval accuracy is characterised with respect to different land surface types. The retrieval works best over water and vegetated surfaces, whereas a surface covered by permanent snow and ice or barren reduces the cirrus detection ability and increases the retrieval errors for the ice optical thickness and ice water path if the cirrus cloud is thin (optical thickness less than approx. 0.3. Second, the retrieval accuracy is characterised with respect to the vertical arrangement of liquid, ice clouds and aerosol layers as derived from CALIOP lidar data. The CiPS retrievals show little interference from liquid water clouds and aerosol layers below an observed cirrus cloud. A liquid water cloud vertically close or adjacent to the cirrus clearly increases the average retrieval errors for the optical thickness and ice water path, respectively, only for thin cirrus clouds with an optical thickness below 0.3 or ice water path below 5.0 g m−2. For the cloud top height retrieval, only aerosol layers affect the retrieval error, with an increased positive bias when the cirrus is at low altitudes. Third, the CiPS retrieval error is

  9. A website evaluation model by integration of previous evaluation models using a quantitative approach

    Directory of Open Access Journals (Sweden)

    Ali Moeini

    2015-01-01

    Full Text Available Regarding the ecommerce growth, websites play an essential role in business success. Therefore, many authors have offered website evaluation models since 1995. Although, the multiplicity and diversity of evaluation models make it difficult to integrate them into a single comprehensive model. In this paper a quantitative method has been used to integrate previous models into a comprehensive model that is compatible with them. In this approach the researcher judgment has no role in integration of models and the new model takes its validity from 93 previous models and systematic quantitative approach.

  10. Improvement of Waste Tire Pyrolysis Oil and Performance Test with Diesel in CI Engine

    Directory of Open Access Journals (Sweden)

    M. N. Islam

    2016-01-01

    Full Text Available The standard of living, quality of life, and development of a nation depend on its per capita energy consumption. Global energy supply that mainly depends on fossil fuel is decreasing day by day. It is estimated that the energy demand will be increased five times by the year 2021 from present scenario. Due to the fossil fuel crisis, the development of alternative fuel technologies has drawn more attraction to deliver the replacement of fossil fuel. Pyrolysis is one of the promising alternative fuel technologies which produces valuable oil, char, and gas product from organic waste. Early investigations report that tire pyrolysis oil extracted from vacuum pyrolysis method seemed to have properties similar to diesel fuel. The main concern of this paper is to produce and improve the properties of crude tire pyrolysis oil by desulfurizing, distilling, and utilizing it with diesel in CI engine to analyze the efficiency for various compositions.

  11. Partnerstwo publiczno – prywatne w świetle Krajowego Standardu Rachunkowości nr 10

    Directory of Open Access Journals (Sweden)

    Dorota Adamek-Hyska

    2017-09-01

    Full Text Available Partnerstwo publiczno – prywatne w świetle Krajowego Standardu Rachunkowości nr 10 In Poland, the concept of public-private partnership generates many dilemmas in valuation, accounting records and the reporting of essential assets and liabilities. This issue is addressed by National Accounting Standard No. 10, which outlines the principles of PPP accounting in public and private accounting systems. The purpose of this paper is to analyze and evaluate the solutions adopted in National Accounting Standard No. 10 against the background of synthetic PPP characteristics. The research methods used are based on a critical analysis of national legislation, a comparative analysis of national and international accounting standards, and a literature analysis of public-private partnerships, public finances and financial accounting. The paper uses the conclusions from the observations of financial aspects of selected public-private partnership contracts as well as concession contracts for construction works and services in Poland

  12. Crianças de seis anos no ensino fundamental: elementos de ciências em escolas rurais do município de Três Pontas/MG

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    Glória Lúcia Magalhães

    2008-01-01

    Full Text Available MAGALHÃES, G. L. Crianças de seis anos no ensino fundamental: elementos de ciências em escolas rurais do município de Três Pontas/MG. 164 fl. 2008. Dissertação (Mestrado em Educação – Faculdade de Educação, Universidade Estadual de Campinas, Campinas, 2008.

  13. Determining the Optimum Cut-Off Grades in Sulfide Copper Deposits / Określanie Optymalnej Wartości Odcięcia Zawartości Procentowej Pierwiastka Użytecznego W Złożach Siarczku Miedzi

    Science.gov (United States)

    Rahimi, Esmaeil; Oraee, Kazem; Shafahi, Zia Aldin; Ghasemzadeh, Hasan

    2015-03-01

    Optimum cut-off grades determination in mining life affects production planning and ultimate pit limit and it is also important from social, economical and environmental aspects. Calculation of optimum cut-off grades has been less considered for mines containing various mineral processing methods. In this paper, an optimization technique is applied to obtain optimum cut-off grades for both concentration and heap leaching processes. In this technique, production costs and different recoveries of heap leaching method directed into modeling different annual cash flows in copper mines. Considering the governing constraints, the Lagrange multiplier method is practiced to optimize the cut-off grades in which the objective function is supposed to maximize Net Present Value. The results indicate the effect of heap leaching process on the optimum cut-off grades of primary and secondary sulfide deposits. Określanie optymalnego poziomu odcięcia dla zawartości procentowej pierwiastka użytecznego ma poważny wpływ na planowanie produkcji, określanie ostatecznych limitów zasobów złoża; jest to także ważna kwestia z punktu widzenia kwestii społecznych, ekonomicznych i środowiskowych. Obliczanie optymalnego poziomu odcięcia dla zawartości procentowej pierwiastka użytecznego nie było zwykle szeroko rozważane w przypadku kopalni prowadzących ciągły system przeróbki. W pracy tej przedstawiono technikę optymalizacji określania poziomu zawartości procentowej pierwiastka użytecznego z uwzględnieniem zarówno procesów koncentracji jak i ługowania. W metodzie uwzględniono koszty produkcji i różne wskaźniki odzysku rudy, wielkości te wykorzystane zostały do modelowania rocznych przepływów gotówki w kopalniach miedzi. Uwzględniając narzucone ograniczenia, zastosowano metodę mnożników Lagrange'a w celu optymalizacji określania poziomu zawartości procentowej pierwiastka użytecznego, gdzie przyjętą funkcją celu jest maksymalizacja wartości bie

  14. Neuroprotekcyjne właściwości związków pochodzenia roślinnego: triterpeny pentacykliczne

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    Monika Orłowska-Majdak

    2014-12-01

    Full Text Available Ludzki mózg to struktura wykazująca ogromną zmienność w ciągu życia osobniczego. W pierwszym okresie zmiany budowy i czynności spowodowane są procesami rozwoju i dojrzewania. Następnie, dzięki niezwykłej plastyczności synaptycznej, poszczególne ośrodki mózgu przystosowują się do wymagań środowiska, w jakim człowiek funkcjonuje, i do stylu jego życia. Po 40. roku życia włącza się proces zaprogramowanej śmierci neuronów, czyli apoptozy, a w stanie choroby neurony mogą ginąć w procesie nekrozy lub aponekrozy. Neurogeneza na bazie miejscowych albo transplantowanych komórek macierzystych mózgu pełni funkcję naprawczą w powstałych uszkodzeniach, ale może także mieć związek z chorobami psychicznymi i neurologicznymi. U podstaw neuroprotekcji leżą procesy antyoksydacyjne, przeciwzapalne, antyapoptotyczne i przeciwdziałające destrukcyjnemu działaniu jonów wapnia. Wspierającą funkcję w działaniu neuroprotekcyjnym mogą mieć związki pochodzenia roślinnego, podawane w ramach fitoterapii. W ostatnich latach zwrócono uwagę na neuroprotekcyjne właściwości pentacyklicznych triterpenów i ich pochodnych. W pracy omówiono właściwości neuroprotekcyjne kwasu ursolowego, oleanolowego, maslinowego, asjatowego, betulinowego, bosweliowego oraz saponin triterpenowych pozyskiwanych z roślin Bupleurum i Panax ginseng. Saponiny ginseng dodatkowo nasilają neurogenezę w mózgu. Sugeruje się potencjał stosowania wymienionych związków w terapii wielu chorób neurologicznych i psychicznych – z kilkoma zastrzeżeniami: 1 kierunek działania może zależeć od dawki; 2 związki te mogą różnie działać na neurony różnych rodzajów; 3 mogą istnieć niekorzystne interakcje z innymi lekami stosowanymi równocześnie. Większość doświadczeń z użyciem triterpenów wykonano na zwierzętach bądź w hodowlach komórkowych, zagadnienie wymaga więc dalszych badań na ludziach.

  15. Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI

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    Merja Ahonen

    2017-03-01

    Full Text Available Infections and infectious diseases are considered a major challenge to human health in healthcare units worldwide. This opinion paper was initiated by EU COST Action network AMiCI (AntiMicrobial Coating Innovations and focuses on scientific information essential for weighing the risks and benefits of antimicrobial surfaces in healthcare settings. Particular attention is drawn on nanomaterial-based antimicrobial surfaces in frequently-touched areas in healthcare settings and the potential of these nano-enabled coatings to induce (ecotoxicological hazard and antimicrobial resistance. Possibilities to minimize those risks e.g., at the level of safe-by-design are demonstrated.

  16. Application of biosurfactants for heavy netals leaching from immobilized activated sludge / Zastosowanie biosurfaktantów do wymywania metali ciężkich z immobilizowanego osadu czynnego

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    Kuczajowska-Zadrożna Małgorzata

    2015-03-01

    Full Text Available W pracy podjęto badania nad określeniem efektywności wykorzystania biosurfaktantów - saponiny, taniny oraz ramnolipidów JBR 515 i JBR 425 do wymywania kadmu, cynku i miedzi z osadu czynnego immobilizowanego w alginianie sodu 1,5% z alkoholem poliwinylowym 0,5%. Przeprowadzone badania pozwoliły określić wpływ odczynu na regenerację biosorbentu za pomocą testowanych biosurfaktantów, wyznaczyć krytyczne stężenie micelarne (CMC w roztworach zawierających biosorbent i biosurfaktant oraz w próbach właściwych z metalami ciężkimi. Saponina charakteryzowała się najwyższą efektywnością wymywania metali przy pH 1-5, a ramnolipidy przy pH 5-6. Ponadto badania wykazały istotny wpływ stosunku masy biosorbentu do objętości eluatu (m/V na skuteczność wymywania metali. Spośród analizowanych biosurfaktantów saponina wykazywała około 100% efektywność usuwania z biosorbentu cynku i miedzi. Skuteczność innych biosurfaktantów była niższa i zależała od rodzaju metalu

  17. A pesquisa discente nos cursos de graduação em biblioteconomia e ciência da informação

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    César Augusto Castro

    Full Text Available Discute-se a importância da pesquisa discente nos cursos de graduação em Biblioteconomia e Ciência da Informação. Enfocam-se os diferentes tipos e os níveis de participação dos alunos em projetos de pesquisa. Aborda-se a monografia de conclusão de curso e o estágio como meios pelos quais os discentes buscam, a partir de referenciais teóricos e metodológicos, refletir criticamente sobre os problemas das Unidades de Informação.

  18. Arquivos Brasileiros de Psiquiatria, Neurologia e Ciências Afins: uma fonte com muita história Arquivos Brasileiros de Psiquiatria, Neurologia e Ciências Afins: a source rich in history

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    Cristiana Facchinetti

    2010-12-01

    Full Text Available Surgido em 1905, o Arquivos Brasileiros de Psiquiatria, Neurologia e Ciências Afins foi o primeiro periódico brasileiro especializado na área. Com o nome de Arquivos Brasileiros de Psiquiatria, Neurologia e Medicina Legal, tornou-se, em 1908, veículo de divulgação da Sociedade com o mesmo nome. A partir de 1919 foi publicado como Arquivos Brasileiros de Neuriatria e Psiquiatria. O periódico traz as propostas para a psiquiatria brasileira lideradas por Juliano Moreira, diretor do Hospício Nacional e da Assistência a Alienados do Distrito Federal. Por veicular trabalhos de profissionais do Hospício Nacional, é fonte fundamental para a investigação dos processos diagnósticos e das práticas clínicas e terapêuticas do período. Apresenta-se aqui uma seleção de artigos publicados na revista entre 1905 e 1930, ano da aposentadoria de Moreira.Launched in 1905, the Arquivos Brasileiros de Psiquiatria, Neurologia e Ciências Afins was the first Brazilian periodical specialized in psychiatry, neurology, and related sciences. In 1908, under the new name of Arquivos Brasileiros de Psiquiatria, Neurologia e Medicina Legal, it became the journal of the Society of Psychiatry, Neurology, and Forensic Medicine. Starting in 1919, it was published under the title Arquivos Brasileiros de Neuriatria e Psiquiatria. The periodical presents proposals put forward for this field in Brazil, under the leadership of Juliano Moreira, director of both the National Asylum and of Federal District Assistance for the Insane (Assistência a Alienados do Distrito Federal. Because the journal published articles by healthcare providers from the National Asylum, it is a vital source for researchers of the era's diagnostic processes and clinical and therapeutic practices. This selection of texts was published in its pages between 1905 and 1930, the year Moreira retired.

  19. A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats.

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    Nadine Held

    Full Text Available The LEW/Ztm-ci2 rat is an animal model for syndromal deafness that arose from a spontaneous mutation. Homozygous animals show locomotor abnormalities like lateralized circling behavior. Additionally, an impaired vision can be observed in some animals through behavioral studies. Syndromal deafness as well as retinal degeneration are features of the Usher syndrome in humans. In the present study, the mutation was identified as a base substitution (T->C in exon 56 of Myo15, leading to an amino acid exchange from leucine (Leu to proline (Pro within the carboxy-terminal MyTH4 domain in the proteins' tail region. Myo15 mRNA was expressed in the retina as demonstrated for the first time with the help of in-situ hybridization and PCR. To characterize the visual phenotype, rats were examined by scotopic and photopic electroretinography and, additionally, histological analyses of the retinas were conducted. The complete loss of sight was detected along with a severe degeneration of photoreceptor cells. Interestingly, the manifestation of the disease does not solely depend on the mutation, but also on environmental factors. Since the LEW/Ztm-ci2 rat features the entire range of symptoms of the human Usher syndrome we think that this strain is an appropriate model for this disease. Our findings display that mutations in binding domains of myosin XV do not only cause non-syndromic hearing loss but can also lead to syndromic disorders including retinal dysfunction.

  20. Professor/a de ciências naturais e de química: a busca de uma identidade

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    Lopes, Cesar Valmor Machado

    2004-01-01

    Full Text Available Este artigo aborda uma investigação sobre a constituição de identidades docentes, realizada junto a um grupo de professores e professoras de química e ciências naturais, em atuação na Escola Básica, na grande Porto Alegre-RS, participantes de um curso de formação continuada coordenado pela Área de Educação Química da UFRGS. Para tanto, partiu-se das representações de ciências naturais e química que estes professores e professoras constroem/construíram buscando sua integração com as representações de professor e professora. Estas representações são analisadas a partir dos textos produzidos por este grupo em situações de debate em grupo, entrevistas, produção textual e demais situações vivenciadas durante a realização do curso. Os registros foram realizados com anotações, gravações em vídeo e/ou áudio e leitura dos trabalhos escritos pelos participantes. Donde destacam-se algumas representações que se apresentaram de forma recorrente, e propõe-se uma reflexão sobre a constituição destas, seus espaços de produção e sua reprodução nos espaços escolares