WorldWideScience

Sample records for previous activity maintenance

  1. Maintenance Activity Planning by Reability Centered Maintenance II Method

    Directory of Open Access Journals (Sweden)

    Rachmad Hidayat

    2010-10-01

    Full Text Available This research discuss maintenance activity by using RCM II method to determine failure function risk at compresor screw. Calculation is given to magnitude optimum time maintenance interval by considering the cost maintenance and the cost reparation. From the research results with RPN points out that critical component that needs to get main priority in give maintenance on compresor screw are bust logistic on timeworn piston, and on filter's sponge airs to come out damage that gets RPN 45. Optimum maintenance interval point one that acquired to prevent failure on compresor screw smaller than appreciative MTTF which indicate optimum maintenance interval in avoiding its bust happening logistic component before happening damage.

  2. Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in rats.

    Science.gov (United States)

    Voigt, Robin M; Mickiewicz, Amanda L; Napier, T Celeste

    2011-11-20

    The atypical antidepressant mirtazapine enhances monoaminergic transmission; thus, mirtazapine therapy may counter the hypo-activation of monoamine systems associated with withdrawal from methamphetamine abuse. Human addiction therapy will likely require chronic administration that is given after brain and behavioral maladaptations are established. To emulate this scenario in rats, we ascertained if acute or repeated mirtazapine treatments could antagonize previously established consequences of repeated methamphetamine. Methamphetamine-induced conditioned place preference (CPP) was used, wherein methamphetamine (1mg/kg, i.p.) was administered in a unique environmental context once-daily for three days interposed by saline injections in an alternate context. Subsequently, mirtazapine (5mg/kg, i.p.) was administered in the home cage either as 10 once-daily injections or a single injection. The expression of CPP was determined in drug-free rats three days after the last mirtazapine injection. Expression of methamphetamine-induced CPP was inhibited by 10 home cage administrations of mirtazapine but not by a single injection of mirtazapine. These findings reveal that mirtazapine can inhibit the maintenance of methamphetamine-induced CPP and that treatment duration and/or treatment timing contributes to this effect of mirtazapine. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. Inspection of licensee - Maintenance programme and activities

    International Nuclear Information System (INIS)

    2013-01-01

    An effective maintenance programme is critical to sustained safe and reliable operation of nuclear power plants. The Working Group on Inspection Practices (WGIP) concluded that when a licensee has an effective maintenance programme, the overall operating safety of the plant is improved and the protection of public health and safety enhanced. All Regulatory Bodies (RB) consider maintenance to be an important area for oversight. Although a variety of inspection practices are being used; RB are actively monitoring licensee performance. Specifically the following conclusions were reached and commendable practices identified: - Maintenance oversight by regulators appears to be in a stable continuous improvement state. Most regulators are executing inspection oversight based on an existing regulatory framework. - The performance of a licensee's maintenance programme is recognized as important part of maintaining nuclear safety. The result of the maintenance program assessment is included in the overall performance assessment of a license. - Maintenance inspection activities are recognized as an important part of the regulatory oversight process. Inspection activities are based on the safety significance and nature of work being performed by the licensee. - The effectiveness of the maintenance inspection activities is recognized to rely on properly qualified inspectors; who are adequately supported by specialists. Training and qualification of inspectors should be based on how the RB reviews and inspects licensee maintenance programmes. - Reporting requirements are identified to provide information on the licensees maintenance programme, and to help guide inspection activities. - Performance Indicators are recognized as a useful tool for helping focus regulatory activities. Basic PI are identified and tracked by the RB, and use of PI by the licensee is monitored. - Inspections are designed to confirm that the licensee is planning and scheduling maintenance with due

  4. Overview of maintenance principles and regulatory supervision of maintenance activities at nuclear power plants in Slovakia

    International Nuclear Information System (INIS)

    Rohar, S.; Cepcek, S.

    1997-01-01

    The maintenance represents one of the most important tools to ensure safe and reliable operation of nuclear power plants. The emphasis of Nuclear Regulatory Authority of the Slovak Republic to the maintenance issue is expressed by requirements in the regulations. The current practice of maintenance management in operated nuclear power plants in Slovak Republic is presented. Main aspects of maintenance, as maintenance programme, organization of maintenance, responsibilities for maintenance are described. Activities of nuclear regulatory authority in maintenance process are presented too. (author)

  5. Building Maintenance. Math Learning Activity Packet.

    Science.gov (United States)

    Grant, Shelia I.

    This collection of learning activities is intended for use in reinforcing mathematics instruction as it relates to building maintenance. Fifty activity sheets are provided. These are organized into units on the following topics: numeration, adding whole numbers, subtracting whole numbers, multiplying whole numbers, dividing whole numbers,…

  6. Influence of previous participation in physical activity on its ...

    African Journals Online (AJOL)

    ... participation can influence perceptions of PA among the students. Physical activity promotion programmes should consider the role of these factors which should be emphasised from childhood. Keywords: physical activity, students, perceived benefits, perceived barriers, previous participation, sedentary lifestyle, Rwanda

  7. Cognitive Aging: Activity Patterns and Maintenance Intentions

    Science.gov (United States)

    Gilhooly, K. J.; Gilhooly, M. L.; Phillips, L. H.; Harvey, D.; Murray, A.; Hanlon, P.

    2007-01-01

    This study examined relationships between cognitive functioning in older people and (1) levels of mental, physical and social activities, and (2) intentions regarding maintenance of cognitive functioning. Participants (N = 145) were 70-91 years of age, varied in health status and socio-economic backgrounds. Current cognitive functioning was…

  8. Reduced dose maintenance eculizumab in atypical hemolytic uremic syndrome (aHUS: an update on a previous case report

    Directory of Open Access Journals (Sweden)

    Halka K

    2011-11-01

    Full Text Available Maro Ohanian, Christian Cable, Kathleen Halka Department of Hematology/Oncology, Scott & White Healthcare and The Texas A&M Health Science Center, College of Medicine, Temple, TX, USA Objective: To describe how maintenance eculizumab sustains improved renal function in severe atypical hemolytic uremic syndrome (aHUS. Case report: A previously described 50-year-old woman with aHUS had a remarkable recovery with eculizumab, which safely reversed profound neurologic damage and eliminated the need for dialysis. Her recovery has been sustained on long-term eculizumab treatment. She initially received eculizumab 900 mg weekly for four doses. On week 5 she commenced maintenance therapy starting at 1200 mg every 2 weeks. Due to nausea and vomiting at that dose, the maintenance dosing was reduced to 600 mg weekly, beginning on dose seven. After receiving 600 mg weekly for nine doses, eculizumab was then reduced to 600 mg every 2 weeks, with continued improvement in renal function. This dosing is lower than the usual 1200 mg every 2 weeks described in the adult literature and used in current clinical trials of aHUS. Conclusion: Six months after the initial diagnosis, our patient continues to have improved renal function on maintenance doses of eculizumab as low as 600 mg every 2 weeks. Keywords: eculizumab, aHUS, thrombotic microangiopathy, atypical hemolytic uremic syndrome

  9. Process cells dismantling of EUREX pant: previous activities

    International Nuclear Information System (INIS)

    Gili, M.

    1998-01-01

    In the '98-'99 period some process cells of the EUREX pant will be dismantled, in order to place there the liquid wastes conditioning plant 'CORA'. This report resumes the previous activities (plant rinsing campaigns and inactive Cell 014 dismantling), run in the past three years and the drawn experience [it

  10. DEMO Active Maintenance Facility concept progress 2012

    International Nuclear Information System (INIS)

    Thomas, Justin; Loving, Antony; Crofts, Oliver; Morgan, Robert; Harman, Jon

    2014-01-01

    The DEMO Active Maintenance Facility (AMF) would be used for the storage, handling and processing of In-Vessel Components (IVC) throughout their time on site, the only exception being the time that they are installed in the vessel. It is anticipated that all handling operations associated with used components will have to be carried out using remote handling techniques. During plasma operations the In-Vessel Components are exposed to high levels of neutron activation. This activation results in high radiation dose rates and decay heating. This presents a significant problem for Remote Handling Equipment (RHE) in the AMF. The high dose rates require the equipment to be sufficiently radiation tolerant to allow it to work reliably for long periods. The decay heating requires forced cooling of newly removed IVC's while they are in storage. The duration of the storage is dependent on the decay heating reducing to a level that has been nominally set at <50 °C without active cooling in room temperature air. This paper summarises the progress made in 2012 on the conceptual design of the AMF and its facilities. The layout and proposed function of the main areas will be described along with the principles applied. The design of the AMF has evolved from a simple representation of the required facilities in 2011 to a concept that can be developed to support maintenance of DEMO

  11. Physical activity maintenance in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Loeppenthin, K; Esbensen, Bente Appel; Østergaard, Mikkel

    2014-01-01

    OBJECTIVE: To describe the experience of physical activity maintenance in patients with rheumatoid arthritis. DESIGN: A qualitative salutogenic-oriented interview study. SETTING: A rheumatology outpatient clinic. SUBJECTS: A purposive sample of 16 physically active patients (mean age 50, range 37...... with non-arthritis populations. CONCLUSION: This study demonstrates that physical activity in patients with rheumatoid arthritis may be understood as a resource to resist disability and to feel and stay healthy while creating and sustaining meaningfulness in life.......OBJECTIVE: To describe the experience of physical activity maintenance in patients with rheumatoid arthritis. DESIGN: A qualitative salutogenic-oriented interview study. SETTING: A rheumatology outpatient clinic. SUBJECTS: A purposive sample of 16 physically active patients (mean age 50, range 37......-67) diagnosed with rheumatoid arthritis on average 21 years previously (range 4-46 years). METHODS: In-depth interviews were conducted using a semi-structured interview guide to illuminate how the phenomenon 'physical activity maintenance' was experienced by patients with rheumatoid arthritis. The interviews...

  12. Motivational activities based on previous knowledge of students

    Science.gov (United States)

    García, J. A.; Gómez-Robledo, L.; Huertas, R.; Perales, F. J.

    2014-07-01

    Academic results depend strongly on the individual circumstances of students: background, motivation and aptitude. We think that academic activities conducted to increase motivation must be tuned to the special situation of the students. Main goal of this work is analyze the students in the first year of the Degree in Optics and Optometry in the University of Granada and the suitability of an activity designed for those students. Initial data were obtained from a survey inquiring about the reasons to choose this degree, their knowledge of it, and previous academic backgrounds. Results show that: 1) the group is quite heterogeneous, since students have very different background. 2) Reasons to choose the Degree in Optics and Optometry are also very different, and in many cases were selected as a second option. 3) Knowledge and motivations about the Degree are in general quite low. Trying to increase the motivation of the students we designed an academic activity in which we show different topics studied in the Degree. Results show that students that have been involved in this activity are the most motivated and most satisfied with their election of the degree.

  13. Regulatory control of maintenance activities in Argentine nuclear power plants

    International Nuclear Information System (INIS)

    Calvo, J.C.; Caruso, G.

    2000-01-01

    The main maintenance objective is to assure that the safety features of structures, components and systems of nuclear power plants are kept as designed. Therefore, there is a direct relationship between safety and maintenance. Owing to the above mentioned, maintenance activities are considered a relevant regulatory issue for the Argentine Nuclear Regulatory Authority (ARN). This paper describes the regulatory control to maintenance activities of Argentine nuclear power plants. It also addresses essential elements for maintenance control, routine inspections, special inspections during planned outages, audits and license conditions and requirements. (author)

  14. Study on application of safety checklist in preventive maintenance activities

    International Nuclear Information System (INIS)

    Shi Jin; Chen Song; Liu Jingquan

    2013-01-01

    The paper describes the principles and the characteristics of safety checklist as a risk evaluation method. Examples of application of safety checklists to preventive maintenance activities such as criteria comparison and checkup items in place in nuclear power plants are illustrated in details with issues appeared in the checklist establishment. Checklist has a good application in the RCM analysis or in the actual preventive maintenance program for Chashma Nuclear Power Plant indicated by concrete instances. In the light of safety checklist which is used to sustain preventive maintenance as a simple and applicable risk analysis approach, we can get deep knowledge of risks of nuclear power plant to perfect preventive maintenance activities. (authors)

  15. Performing maintenance activities on-line a risk perspective

    International Nuclear Information System (INIS)

    Darling, S.S.; Mairs, T.P.

    1993-01-01

    The US nuclear power industry is attempting to deal with the issue of optimizing the performance of maintenance activities with the advent of the maintenance rule. The impact of any maintenance activity on the safe operation of a nuclear power facility can be quantified on the basis of risk. Therefore, it is incumbent upon the industry to accommodate the regulator and present a maintenance optimization program in terms that explicitly address the potential risk inherent in its concept and implementation. The motivation for utilities to perform maintenance while the plant is operating (i.e., on-line) is readily perceived to offer the following advantages: 1. greater system availability; 2. higher plant capacity factor; 3. more evenly distributed workload for the maintenance department; and 4. overall safer plant operation. However, risks inherent in undertaking maintenance activities during power operation could amount to the realization that reapportionment of these tasks is not cost-beneficial. Therefore, it is important that any utility considering implementing such a paradigm in maintenance philosophy establish a rigorous process to select, perform, and monitor maintenance tasks performed while operating

  16. Building Maintenance. Reading and Language Activities.

    Science.gov (United States)

    Kessman, William A.

    The student manual has been designed primarily for beginning students in a high school level vocational program in building maintenance. A workbook for special needs students, the document does not cover all areas of custodial training but has been written for the purpose of refining the basic skills of reading comprehension, vocabulary building,…

  17. KNOWLEDGE MANAGEMENT FOR MAINTENANCE ACTIVITIES IN THE MANUFACTURING SECTOR

    Directory of Open Access Journals (Sweden)

    M.A. Mansor

    2012-06-01

    Full Text Available Maintenance is an indispensable part of the business process and plays an important role in an organisation’s success and survival. The main purpose of maintenance is to ensure equipment functions at its original optimal level. Thus, the knowledge and skills of operators are crucial and in demand. This paper presents a knowledge management of maintenance activities transfer method. Knowledge management is a process that a company cannot avoid, because it is a step in providing the necessary information for business performance measurements. Based on the example of a knowledge management system for a consultant company, we propose a knowledge repository or warehouse for maintenance activities that consists of four elements: best practice, databases, discussion forums and assessment tools. Each element has its own role and contribution towards better maintenance activities. Therefore, knowledge management has a deep relationship with performance evaluation or measurement.

  18. Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy

    DEFF Research Database (Denmark)

    Kirk, Ole; Reiss, Peter; Uberti-Foppa, Caterina

    2002-01-01

    maintenance therapy for cytomegalovirus (CMV) end-organ disease, disseminated Mycobacterium avium complex (MAC) infection, cerebral toxoplasmosis, and extrapulmonary cryptococcosis in patients receiving antiretroviral therapy. DESIGN: Observational study. SETTING: Seven European HIV cohorts. PATIENTS: 358...... identified: 162 for CMV disease, 103 for MAC infection, 75 for toxoplasmosis, and 39 for cryptococcosis. During 781 person-years of follow-up, five patients had relapse. Two relapses (one of CMV disease and one of MAC infection) were diagnosed after maintenance therapy was interrupted when the CD4 lymphocyte....... One relapse (toxoplasmosis) was diagnosed after maintenance therapy interruption at a CD4 lymphocyte count greater than 200 x 10(6) cells/L for 15 months. The overall incidences of recurrent CMV disease, MAC infection, toxoplasmosis, and cryptococcosis were 0.54 per 100 person-years (95% CI, 0.07 to 1...

  19. Risk mitigation strategies for operations and maintenance activities.

    Science.gov (United States)

    2012-04-01

    The objective of this research was to investigate the application of integrated risk modeling to operations and maintenance activities, specifically moving operations, such as pavement testing, pavement marking, painting, snow removal, shoulder work,...

  20. Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy

    DEFF Research Database (Denmark)

    Kirk, Ole; Reiss, Peter; Uberti-Foppa, Caterina

    2002-01-01

    identified: 162 for CMV disease, 103 for MAC infection, 75 for toxoplasmosis, and 39 for cryptococcosis. During 781 person-years of follow-up, five patients had relapse. Two relapses (one of CMV disease and one of MAC infection) were diagnosed after maintenance therapy was interrupted when the CD4 lymphocyte...

  1. Adolescents' physical activity is associated with previous and current physical activity practice by their parents

    Directory of Open Access Journals (Sweden)

    Diego Giulliano Destro Christofaro

    Full Text Available Abstract Objective: The purpose of this study was to determine whether parents' current and previous physical activity practice is associated with adolescents' physical activity. Methods: The sample was composed of 1231 adolescents (14-17 years, and 1202 mothers and 871 fathers were interviewed. Weight and height of the adolescents were measured. Self-reported parents' weight and height were obtained. The current and previous physical activity levels (Baecke's questionnaire of parents (during childhood and adolescence and adolescents' physical activity levels were obtained using a questionnaire. The magnitude of the associations between parent and adolescent physical activity levels was determined by binary logistic regression (adjusted by sex, age, and socioeconomic level of adolescents and education level of parents. Results: The current physical activity practice by parents was associated with adolescents' physical activity (p < 0.001. The physical activities reported by parents in their childhood and adolescence were also associated with higher physical activity levels among adolescents. Adolescents whose parents were both physically active in the past and present were six times (OR = 6.67 [CI = 1.94-22.79] more likely to be physically active compared to adolescents with no parents who were physically active in the past. Conclusions: The current and previous physical activities of parents were associated with higher levels of physical activity in adolescents, even after controlling for confounding factors.

  2. Adolescents' physical activity is associated with previous and current physical activity practice by their parents.

    Science.gov (United States)

    Christofaro, Diego Giulliano Destro; Andersen, Lars Bo; Andrade, Selma Maffei de; Barros, Mauro Virgílio Gomes de; Saraiva, Bruna Thamyres Ciccotti; Fernandes, Rômulo Araújo; Ritti-Dias, Raphael Mendes

    The purpose of this study was to determine whether parents' current and previous physical activity practice is associated with adolescents' physical activity. The sample was composed of 1231 adolescents (14-17 years), and 1202 mothers and 871 fathers were interviewed. Weight and height of the adolescents were measured. Self-reported parents' weight and height were obtained. The current and previous physical activity levels (Baecke's questionnaire) of parents (during childhood and adolescence) and adolescents' physical activity levels were obtained using a questionnaire. The magnitude of the associations between parent and adolescent physical activity levels was determined by binary logistic regression (adjusted by sex, age, and socioeconomic level of adolescents and education level of parents). The current physical activity practice by parents was associated with adolescents' physical activity (pparents in their childhood and adolescence were also associated with higher physical activity levels among adolescents. Adolescents whose parents were both physically active in the past and present were six times (OR=6.67 [CI=1.94-22.79]) more likely to be physically active compared to adolescents with no parents who were physically active in the past. The current and previous physical activities of parents were associated with higher levels of physical activity in adolescents, even after controlling for confounding factors. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  3. Summary of typical routine maintenance activities at Tokai Reprocessing Plant. Supplement (March, 2002)

    International Nuclear Information System (INIS)

    2002-03-01

    Typical maintenance activities, such as replacement of worn out parts and cleaning of filter elements, routinely performed during steady operation are summarized. [The Summary of Typical Routine Maintenance Activities at Tokai Reprocessing Plant] (JNC TN 8450 2001-006) was already prepared in September, 2001. The purpose of this summary is to give elementary understanding on these activities to people who are responsible for explanation them to the public. At this time, the same kind of summary is prepared as a supplement of the previous one. (author)

  4. Maintenance of the JET active gas handling system

    International Nuclear Information System (INIS)

    Brennan, P.D.; Bell, A.C.; Brown, K.; Cole, C.; Cooper, B.; Gibbons, C.; Harris, M.; Jones, G.; Knipe, S.; Lewis, J.; Manning, C.; Miller, A.; Perevezentsev, A.; Skinner, N.; Stagg, R.; Stead, M.; Thomas, R.; Yorkshades, J.

    2003-01-01

    The JET active gas handling system (AGHS) has been in operation in conjunction with the JET machine since Spring 1997. The tritium levels within the vessel have remained sufficiently high, 6.2 g at the end of the DTE1 experiment and currently 1.5 g, such that the AGHS has been required to operate continuously to detritiate gases liberated during D-D operations and to maintain discharges to the environment to ALARP. Maintaining the system to ensure continued operation has been a key factor in guaranteeing the continued availability of the essential sub-systems. The operational history of the JET AGHS has been previously documented in a number of papers [R. Laesser, et al. Proc. of the 19th SOFT Conf. 1 (1996) 227; R. Laesser, et al., Fusion Eng. Des. 46 (1999) 307; P.D. Brennan, et al., 18th Symp. on Fusion Eng., 1999]. Operational downtime is minimised through well-engineered sub-systems that use high integrity components. Outage, contamination and operator dosage are minimised through pre-planned and prepared maintenance operations. The reliability of sub-system critical condition fault detection is demonstrated through routine testing of hard-wired alarms and interlocks

  5. Maintenance of the JET active gas handling system

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, P.D. E-mail: damian.brennan@jet.uk; Bell, A.C.; Brown, K.; Cole, C.; Cooper, B.; Gibbons, C.; Harris, M.; Jones, G.; Knipe, S.; Lewis, J.; Manning, C.; Miller, A.; Perevezentsev, A.; Skinner, N.; Stagg, R.; Stead, M.; Thomas, R.; Yorkshades, J

    2003-09-01

    The JET active gas handling system (AGHS) has been in operation in conjunction with the JET machine since Spring 1997. The tritium levels within the vessel have remained sufficiently high, 6.2 g at the end of the DTE1 experiment and currently 1.5 g, such that the AGHS has been required to operate continuously to detritiate gases liberated during D-D operations and to maintain discharges to the environment to ALARP. Maintaining the system to ensure continued operation has been a key factor in guaranteeing the continued availability of the essential sub-systems. The operational history of the JET AGHS has been previously documented in a number of papers [R. Laesser, et al. Proc. of the 19th SOFT Conf. 1 (1996) 227; R. Laesser, et al., Fusion Eng. Des. 46 (1999) 307; P.D. Brennan, et al., 18th Symp. on Fusion Eng., 1999]. Operational downtime is minimised through well-engineered sub-systems that use high integrity components. Outage, contamination and operator dosage are minimised through pre-planned and prepared maintenance operations. The reliability of sub-system critical condition fault detection is demonstrated through routine testing of hard-wired alarms and interlocks.

  6. Maintenance of physical activity in patients with rheumaoid arthritis

    DEFF Research Database (Denmark)

    Løppenthin, Katrine; Esbensen, Bente Appel; Østergaard, Mikkel

    2012-01-01

    selection was carried out through purposeful sampling. On this basis, participants with self-reported regular physical activity were invited to participate in the study. In total, 16 individuals (12 women and four men; mean age 50), diagnosed with RA for an average of 21 years (range: 4 - 46 years......Background: Several exercise trials indicate that physical activity (PA) may improve physical function and quality of life, and reduce pain in patients with rheumatoid arthritis (RA) 1, 2. Few of these studies have included physical activity maintenance. Thus, it is still unknown how and why some...... patients with RA are able to maintain physical active. Objectives: The aim of this study was to describe the experience of physical activity maintenance in patients with RA. Methods: A qualitative salutogenetic-oriented study was conducted based on individual semi-structured interviews. Interviewee...

  7. Equipment maintenance activities required for the sustenance and ...

    African Journals Online (AJOL)

    This study was designed to investigate those equipment maintenance activities required for the sustenance and growth of woodwork industries in Niger State. Three (3) research questions were formulated to guide this study. Three (3) null hypotheses were also formulated and tested at 0.05 level of significances.

  8. Reducing costs by clustering maintenance activities for multiple critical units

    NARCIS (Netherlands)

    de Jonge, Bram; Klingenberg, Warse; Teunter, Ruud; Tinga, Tiedo

    Advances in sensor technology have enabled companies to make significant progress towards achieving condition-based maintenance (CBM). CBM provides the opportunity to perform maintenance actions more effectively. However, scheduling maintenance at the unit level may imply a high maintenance

  9. Reducing costs by clustering maintenance activities for multiple critical units

    NARCIS (Netherlands)

    de Jonge, Bram; Klingenberg, Warse; Teunter, Ruud; Tinga, Tiedo

    2015-01-01

    Advances in sensor technology have enabled companies to make significant progress towards achieving condition-based maintenance (CBM). CBM provides the opportunity to perform maintenance actions more effectively. However, scheduling maintenance at the unit level may imply a high maintenance

  10. The role of affects and emotions in physical activity maintenance

    Directory of Open Access Journals (Sweden)

    Benjamin Wienke

    2016-08-01

    Full Text Available Although previous research has shown that affective variables are consistently associated with physical activity behavior, the working mechanisms are not understood to the extent of creating an intervention. The aim of this study is to identify situations and aspects of physical activity, which lead to positive affective reactions in people taking part in regular and long-term exercise. In this study 24 adults (12 female, 12 male distributed over three age groups (young, middle, and late adulthood that took part in sport programs (individual or team sport for at least five years. Semi-structured in depth interviews with questions about physical activity, long term participation and affective response in a sporting environment were conducted in order to ascertain those situations and aspects of the exercise program triggering positive affective states. Interviews were transcribed verbatim and followed Grounded Theory principles. Emerging concepts were grouped and merged into different categories representing the key aspects of exercise. Four factors were identified which are associated with emergence of positive emotions in sport and exercise. Firstly, perceived competence is one of the major factors influencing affective states during physical activity representing individual and collective success and progress, competition and challenge. Secondly, perceived social interaction is another factor comprising of all sorts of peer-related aspects such as communication with others, being part of a group and creating close relationships or friendships. Thirdly, novelty experience in contrast to other none-sporting activities such as work, family or other leisure activities was another factor. The last factor found was the perceived physical exertion comprising the degree of exhaustion, a possibly delayed turnaround in the affective response and the aspect of sport being a physical compensation for everyday sedentary life. The results of this study

  11. Public Tourism Infrastructure: Challenges in the Development and Maintenance Activities

    Directory of Open Access Journals (Sweden)

    Abdullah Shardy

    2014-01-01

    Full Text Available In Malaysia, the tourism sector is a major contributor to the nation’s development and is spearheaded by the government’s efforts in investing heavily towards providing sufficient and well-functioning public tourism infrastructure. This infrastructure should be ideally developed with a clear and systematic maintenance plan in hand. The challenge herein is not merely providing the necessary infrastructure to sustain tourism activities but rather a pro-active approach towards establishing and subsequently maintaining this infrastructure at its optimal level. The aim of this paper therefore is to identify critical aspects that need to be in place to further enhance the Malaysian tourism industry. The paper discusses the issues and challenges that need to be addressed as a precursor towards an effectively developed and maintained tourism infrastructure system. Development issues that have been identified revolve around the dimensions of quality, quantity and ability of the public agencies involved, particularly issues of inadequate infrastructure, quality of infrastructure and the capability of the agencies in undertaking efficient maintenance activities. These issues were found to lead towards challenges of working with resource constraints, lack of an effective maintenance culture and system as well as the need for clear and effective policies and strategies.

  12. Basic Characteristics of Human Erroneous Actions during Test and Maintenance Activities Leading to Unplanned Reactor Trips

    International Nuclear Information System (INIS)

    Kim, Jae Whan; Park, Jin Kyun

    2010-01-01

    Test and maintenance (T and M) activities of nuclear power plants are essential for sustaining the safety of a power plant and maintaining the reliability of plant systems and components. However, the potential of human errors during T and M activities has also the potential to induce unplanned reactor trips or power derate or making safety-related systems unavailable. According to the major incident/accident reports of nuclear power plants in Korea, contribution of human errors takes up about 20% of the total events. The previous study presents that most of human-related unplanned reactor trip events during normal power operation are associated with T and M activities (63%), which are comprised of plant maintenance activities such as a 'periodic preventive maintenance (PPM)', a 'planned maintenance (PM)' and a 'corrective maintenance (CM)'. This means that T and M activities should be a major subject for reducing the frequency of human-related unplanned reactor trips. This paper aims to introduce basic characteristics of human erroneous actions involved in the test and maintenance-induced unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants. The basic characteristics are described by dividing human erroneous actions into planning-based errors and execution-based errors. For the events associated with planning failures, they are, firstly, classified according to existence of the work procedure and then described for what aspects of the procedure or work plan have deficiency or problem. On the other hand, for the events associated with execution failures, they are described from the aspect of external error modes

  13. Organization of industrial maintenance in oil pipeline and terminals activities: a project for the implantation of a corporative management system

    Energy Technology Data Exchange (ETDEWEB)

    Correia, Paulo de Tarso Arruda [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil). Diretoria de Terminais e Oleodutos; Arruda, Daniela Mendonca; Oliveira, Italo Luiz [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

    2009-07-01

    This paper discusses the definition and implementation of a corporate management model for industrial maintenance within TRANSPETRO's Terminals and Oil Pipelines business segment. A project is under way to answer the company's needs for better coordination of its maintenance activities as well as to face the challenge of increasing performance with higher systems and equipment' availability, at lower costs. To achieve this target, the project has been employing updating management tools for industrial maintenance planning and control. Its scope comprises the definition of: industrial maintenance process guidelines; industrial maintenance normative requirements and operational procedures; industrial maintenance performance indicators; local organizational charts; training of maintenance personnel; qualification and certification policies; conceptualization of maintenance engineering and maintenance based on risk; updating technologies such as asset management; warehousing and logistics for maintenance support in the supply of spare parts and materials. The project will also consider the results of a previous strategic sourcing study, concerning the definition of the most suitable out sourcing strategy for each operational unit, considering its characteristics as well as the characteristics of the region where it is located. (author)

  14. Human area MT+ shows load-dependent activation during working memory maintenance with continuously morphing stimulation.

    Science.gov (United States)

    Galashan, Daniela; Fehr, Thorsten; Kreiter, Andreas K; Herrmann, Manfred

    2014-07-11

    Initially, human area MT+ was considered a visual area solely processing motion information but further research has shown that it is also involved in various different cognitive operations, such as working memory tasks requiring motion-related information to be maintained or cognitive tasks with implied or expected motion.In the present fMRI study in humans, we focused on MT+ modulation during working memory maintenance using a dynamic shape-tracking working memory task with no motion-related working memory content. Working memory load was systematically varied using complex and simple stimulus material and parametrically increasing retention periods. Activation patterns for the difference between retention of complex and simple memorized stimuli were examined in order to preclude that the reported effects are caused by differences in retrieval. Conjunction analysis over all delay durations for the maintenance of complex versus simple stimuli demonstrated a wide-spread activation pattern. Percent signal change (PSC) in area MT+ revealed a pattern with higher values for the maintenance of complex shapes compared to the retention of a simple circle and with higher values for increasing delay durations. The present data extend previous knowledge by demonstrating that visual area MT+ presents a brain activity pattern usually found in brain regions that are actively involved in working memory maintenance.

  15. A Study on the Maintenance Effectiveness Assessment for Active Components

    International Nuclear Information System (INIS)

    Lim, Woo Sang; Oh, Seung Jong

    2006-01-01

    One of the key tasks in the periodic safety review (PSR) of nuclear power plant is to assess the aging management of structures, systems and components (SSC). The evaluation can be categorized by two parts, passive and active components. Unlike the passive components, active components are periodically maintained and replaced with new components, so the evaluation of aging mechanism of the passive components such as erosion, corrosion is not applicable to the evaluation of active components of nuclear power plant. For active components, they will maintain capability to fulfill its design function if preventive maintenance effectiveness is proper. In this paper, the assessment based on the reliability and availability of the active components of the domestic nuclear power plants is examined

  16. Priority ranking for maintenance activities on embankment dams

    International Nuclear Information System (INIS)

    Chouinard, L.E.; Andersen, G.R.; Robichaud, J.G.; Blanchette, G.; Gervais, R.

    1998-01-01

    Operators of dams in Canada and the U.S. are steadily shifting from construction of new facilities to the maintenance and repairs of existing ones. This paper emphasized the importance of prioritizing maintenance activities on embankment dams whose maintenance needs vary from structure to structure. Two parallel procedures were developed, one for monitoring devices and the other for defense groups. Both procedures are intended to be used together to rate the condition of the embankment dams. The term 'defense groups' is used to refer to the collection of physical components on dams to prevent adverse conditions from occurring that would result in an uncontrolled release of the reservoir. The priority rankings and condition indices developed by means of this procedure reflects the judgment of a panel of engineers and geologists who implement them. They are not to be interpreted as an index of dam safety. While the process is sufficiently well developed to warrant wide-spread distribution, it is considered to be still in the developmental stage. Therefore, it should be used in conjunction with other parallel processes evaluating structural, mechanical and electrical features of the structure under consideration. 6 refs., 7 tabs

  17. 24 CFR 35.1220 - Ongoing lead-based paint maintenance activities.

    Science.gov (United States)

    2010-04-01

    ...-based paint maintenance activities into regular building operations in accordance with § 35.1355(a). ... maintenance activities. 35.1220 Section 35.1220 Housing and Urban Development Office of the Secretary... STRUCTURES Tenant-Based Rental Assistance § 35.1220 Ongoing lead-based paint maintenance activities...

  18. Relationship challenges and relationship maintenance activities following disclosure of transsexualism.

    Science.gov (United States)

    Alegría, C Aramburu

    2010-12-01

    • Transsexual persons are increasing their visibility in society, and health care providers and others (such as social workers) will be called upon to help with issues that transsexual persons face. Challenges that face transsexual persons often include issues involving relationships. Psychiatric and mental health nurses and other caregivers can increase their therapeutic skills in working with couples that include transsexual persons by becoming aware of these challenges and subsequent activities that can help with them. • This research study looks at couple relationships in which one partner reveals male-to-female transsexual identity. These are relationships that were established as man-woman and now will transition into relationships that include a male-to-female person and a female partner. • Common challenges for these couples include issues related to: (1) sexual identity and relationship uncertainty; (2) male-to-female transition decision making; and (3) presenting in public. • Relationship maintenance activities that helped the couples in the study maintain and strengthen their relationships through these challenges include: (1) communication; (2) self-talk (for example, putting the situation in perspective); (3) social networks; (4) positive interactions; (5) impression management (for example, managing displays of affection in public); and (6) social activism. This qualitative study describes the relational dynamics that help sustain relationships of couples that include male-to-female transsexual persons (MTF) and their natal female partners (NF) following disclosure of transsexualism. Relationship challenges and relationship maintenance activities are identified. Each partner in 17 MTF-NF couples participated in individual surveys and interviews. The data were coded for themes related to relationship challenges and activities. MTF-NF couples experience challenges within the contexts of their relationships and of society. These challenges

  19. Brain Activation during Associative Short-Term Memory Maintenance is Not Predictive for Subsequent Retrieval

    Directory of Open Access Journals (Sweden)

    Heiko eBergmann

    2015-09-01

    Full Text Available Performance on working memory (WM tasks may partially be supported by long-term memory (LTM processing. Hence, brain activation recently being implicated in WM may actually have been driven by (incidental LTM formation. We examined which brain regions actually support successful WM processing, rather than being confounded by LTM processes, during the maintenance and probe phase of a WM task. We administered a four-pair (faces and houses associative delayed-match-to-sample (WM task using event-related fMRI and a subsequent associative recognition LTM task, using the same stimuli. This enabled us to analyze subsequent memory effects for both the WM and the LTM test by contrasting correctly recognized pairs with incorrect pairs for either task. Critically, with respect to the subsequent WM effect, we computed this analysis exclusively for trials that were forgotten in the subsequent LTM recognition task. Hence, brain activity associated with successful WM processing was less likely to be confounded by incidental LTM formation. The subsequent LTM effect, in contrast, was analyzed exclusively for pairs that previously had been correctly recognized in the WM task, disclosing brain regions involved in successful LTM formation after successful WM processing. Results for the subsequent WM effect showed no significantly activated brain areas for WM maintenance, possibly due to an insensitivity of fMRI to mechanisms underlying active WM maintenance. In contrast, a correct decision at WM probe was linked to activation in the retrieval success network (anterior and posterior midline brain structures. The subsequent LTM analyses revealed greater activation in left dorsolateral prefrontal cortex and posterior parietal cortex in the early phase of the maintenance stage. No supra-threshold activation was found during the WM probe. Together, we obtained clearer insights in which brain regions support successful WM and LTM without the potential confound of the

  20. Brain activation during associative short-term memory maintenance is not predictive for subsequent retrieval.

    Science.gov (United States)

    Bergmann, Heiko C; Daselaar, Sander M; Beul, Sarah F; Rijpkema, Mark; Fernández, Guillén; Kessels, Roy P C

    2015-01-01

    Performance on working memory (WM) tasks may partially be supported by long-term memory (LTM) processing. Hence, brain activation recently being implicated in WM may actually have been driven by (incidental) LTM formation. We examined which brain regions actually support successful WM processing, rather than being confounded by LTM processes, during the maintenance and probe phase of a WM task. We administered a four-pair (faces and houses) associative delayed-match-to-sample (WM) task using event-related functional MRI (fMRI) and a subsequent associative recognition LTM task, using the same stimuli. This enabled us to analyze subsequent memory effects for both the WM and the LTM test by contrasting correctly recognized pairs with incorrect pairs for either task. Critically, with respect to the subsequent WM effect, we computed this analysis exclusively for trials that were forgotten in the subsequent LTM recognition task. Hence, brain activity associated with successful WM processing was less likely to be confounded by incidental LTM formation. The subsequent LTM effect, in contrast, was analyzed exclusively for pairs that previously had been correctly recognized in the WM task, disclosing brain regions involved in successful LTM formation after successful WM processing. Results for the subsequent WM effect showed no significantly activated brain areas for WM maintenance, possibly due to an insensitivity of fMRI to mechanisms underlying active WM maintenance. In contrast, a correct decision at WM probe was linked to activation in the "retrieval success network" (anterior and posterior midline brain structures). The subsequent LTM analyses revealed greater activation in left dorsolateral prefrontal cortex and posterior parietal cortex in the early phase of the maintenance stage. No supra-threshold activation was found during the WM probe. Together, we obtained clearer insights in which brain regions support successful WM and LTM without the potential confound of

  1. Creating Value by Integrating Logistic Trains Services and Maintenance Activities

    NARCIS (Netherlands)

    Busstra, Marten; van Dongen, Leonardus Adriana Maria

    2015-01-01

    NedTrain is the Netherlands Railway's subsidiary responsible for rolling stock maintenance. Train sets are brought in for short-term routine maintenance after set intervals of some 75 to 120 days. When a major defect occurs, train sets are allocated to one of the three maintenance depots and are

  2. Participation in physical activity: perceptions of women with a previous history of gestational diabetes mellitus.

    Science.gov (United States)

    Graco, Marnie; Garrard, Jan; Jasper, Andrea E

    2009-04-01

    Women with a history of gestational diabetes mellitus (GDM) have an increased risk of developing type 2 diabetes mellitus (T2DM). Regular physical activity plays an important role in preventing T2DM. This study aimed to explore the perceptions of physical activity among women with previous GDM, in the context of preventing T2DM. Individual semi-structured interviews were conducted with 10 women with previous GDM who had not been diagnosed with T2DM. Data were analysed using a modified grounded theory approach. Women perceived diet to be significantly more important for the prevention of T2DM than physical activity. They underestimated the role of physical activity in preventing diabetes, which may have resulted from the lack of information they received following their pregnancy. Women consistently placed the needs of their families before their own, despite acknowledging their future health risks. The most commonly cited constraints on physical activity participation were lack of time, partner support, and appropriate childcare. They identified a need for 'family-friendly' community-based physical activity programs for mothers, more accessible childcare, and more information about the role of physical activity in diabetes prevention. Awareness of the role of physical activity for the prevention of diabetes was low. Physical activity promotion for women with previous GDM needs to be shaped around the opportunities and constraints identified by this population group.

  3. Using an industrial robot for maintenance tele-robotic operations in active cells at Cogema recycling plant

    Energy Technology Data Exchange (ETDEWEB)

    Piolain, G. [COGEMA La Hague (France); Geffard, F. [CEA Commissariat a l' Energie Atomique (France); Coudray, A. [Mecachimie (France)

    2006-07-01

    The purpose of this maintenance operation is to remove the rollers of the dissolver in a high level activity area of a nuclear facility of COGEMA La Hague, a subsidiary of AREVA. This recurrent operation imposes a power slave arm system. This paper shows the advantages of the new system in comparison with the previous one, a remote control manipulator. (authors)

  4. Lessons Learned from Outsourcing the Pearl Harbor MK-48 Intermediate Maintenance Activity

    National Research Council Canada - National Science Library

    Gansler, Jacques S; Lucyshyn, William; Alarcon-Deza, Benigno

    2008-01-01

    During the 1990s, active duty sailor resources were in large demand. In an effort to return sailors to the fleet, the operation of the Navy's Heavyweight Torpedo Intermediate Maintenance Activities (IMA...

  5. Does proximity to physical activity infrastructures predict maintenance of organized and unorganized physical activities in youth?

    Science.gov (United States)

    MacKenzie, Jason; Brunet, Jennifer; Boudreau, Jonathan; Iancu, Horia-Daniel; Bélanger, Mathieu

    2015-01-01

    Physical activity (PA) infrastructures can provide youth chances to engage in PA. As determinants of organized and unorganized PA (OPA and UPA) may differ, we investigated if proximity to PA infrastructures (proximity) was associated with maintenance of OPA and UPA over 3 years. Youth from New Brunswick, Canada (n = 187; 10-12 years at baseline) reported participation in OPA and UPA every 4 months from 2011 to 2014 as part of the MATCH study. Proximity data were drawn from parent's questionnaires. Proximity scores were divided into tertiles. Kaplan-Meier and Cox proportional hazard models were used to assess associations between proximity and maintenance of OPA and UPA. There were no crude or adjusted differences in average maintenance of participation in OPA [mean number of survey cycle participation (95%CI) was 6.6 (5.7-7.5), 6.3 (5.5-7.1), and 5.8 (5.1-6.6)] or UPA [6.8 (6.2-7.4), 5.9 (5.3-6.5), and 6.6 (5.9-7.3)] across low, moderate, and high tertiles of proximity, respectively. Findings suggest that proximity does not affect maintenance of participation in OPA or UPA during adolescence. Other environmental aspects may have a greater effect. Further research is needed before conclusions can be made.

  6. Nuclear power plant maintenance optimisation SENUF network activity

    Energy Technology Data Exchange (ETDEWEB)

    Ahlstrand, R.; Bieth, M.; Pla, P.; Rieg, C.; Trampus, P. [Inst. for Energy, EC DG Joint Research Centre, Petten (Netherlands)

    2004-07-01

    During providing scientific and technical support to TACIS and PHARE nuclear safety programs a large amount of knowledge related to Russian design reactor systems has accumulated and led to creation of a new Network concerning Nuclear Safety in Central and Eastern Europe called ''Safety of Eastern European type Nuclear Facilities'' (SENUF). SENUF contributes to bring together all stakeholders of TACIS and PHARE: beneficiaries, end users, Eastern und Western nuclear industries, and thus, to favour fruitful technical exchanges and feedback of experience. At present the main focus of SENUF is the nuclear power plant maintenance as substantial element of plant operational safety as well as life management. A Working Group has been established on plant maintenance. One of its major tasks in 2004 is to prepare a status report on advanced strategies to optimise maintenance. Optimisation projects have an interface with the plant's overall life management program. Today, almost all plants involved in SENUF network have an explicit policy to extend their service life, thus, component ageing management, modernization and refurbishment actions became much more important. A database is also under development, which intends to help sharing the available knowledge and specific equipment and tools. (orig.)

  7. Design and evaluation of augmented reality for nuclear power plant maintenance based on Cognitive activity analysis

    International Nuclear Information System (INIS)

    Koo, Jwa Jin

    2008-02-01

    The goals of maintenance in nuclear power plants (NPPs) are to reduce the number of plant shutdowns, to decrease the shutdown time, to minimize the maintenance costs, and to improve nuclear safety. Furthermore, it is difficult for maintenance personnel to conduct work in NPPs due to the complexity of NPPs, safety issues and time constraints. Human errors should be prevented to achieve maintenance goals in NPPs. Therefore, it is necessary to improve working conditions by introducing support systems. Augmented Reality (AR) has the potential to assist with maintenance tasks and make maintenance personnel concentrate on the tasks, which will then the reduced human error and improve human performance. The working procedure for AR systems was designed based on the characteristics of cognitive activity, and an experiment was conducted to estimate the effectiveness of AR. The results indicated that a well-designed working procedure for AR systems was more effective than a conventional paper-based working procedure. In addition, participants made fewer errors using the designed working procedure. AR systems as maintenance support systems are beneficial technology that can improve maintenance performance by reducing cognitive loads and unnecessary movements. An AR application can be attractive and effective at supporting maintenance task

  8. Dynamic contracting : An asset management tool in controlling infrastructure maintenance activities

    NARCIS (Netherlands)

    Demirel, H.C.; de Ridder, H.A.J.; Hertogh, M.J.C.M.

    2013-01-01

    Infrastructure road network is a complex system in a fast changing complicated environment and therefore subject to change. The changes refer to demands, requirements, regulations and financial possibilities as well as advanced technologies. Therefore outsourcing maintenance activities are rather

  9. Time Evolution of Activity Concentration of Natural Emitters in a Scenario Affected By Previous Phosphogypsum Contamination

    Science.gov (United States)

    Villa, M.; Mantero, J.; Mosqueda, F.; Hurtado, S.; Manjón, G.; Vaca, F.; García-Tenorio, R.

    2008-08-01

    The estuary formed by the confluence of Tinto and Odiel river-mouths is located in the South of Spain, close to Huelva town. This estuary has been deeply studied through the years because it has a double particularity. On one hand, since the beginning of the 1960s, the estuary has been affected by direct and indirect phosphogypsum (pg.) releases from two phosphoric acid and fertilizers factories that are working in the area. On the other hand, the pyrite mining operations upstream the Odiel and Tinto rivers has caused historically the formation of H2SO4, through oxidation of the natural sulphur deposits, the acidification of the waters and the consequent mobilisation of heavy metals from the mining area to the Huelva estuary. As a consequence, enhancement contamination levels in natural emitters from the 238U series were found in the surroundings of the factories in the previous years to 1998. However, in 1998 the management policy of waste releases drastically changed in the area, and direct discharges to Tinto and Odiel River had to be ceased. A thorough study of the affected zone is being carried out. Riverbed sediments and water samples have been analyzed from four different sampling campaigns in the estuary during the years 1999, 2001, 2002 and 2005. Different radioanalytical techniques have been employed to obtain the activity concentrations of U-isotopes, Th-isotopes, 226Ra, 210Pb and 210Po. Furthermore, the results for the rates of de-contamination of the area are presented. This data will be discussed in order to establish the present status of the contamination in the area, and moreover, to predict the time-evolution of the self-cleaning

  10. CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability.

    Directory of Open Access Journals (Sweden)

    Ori Liraz

    Full Text Available Pyramidal neurons in the piriform cortex from olfactory-discrimination trained rats show enhanced intrinsic neuronal excitability that lasts for several days after learning. Such enhanced intrinsic excitability is mediated by long-term reduction in the post-burst after-hyperpolarization (AHP which is generated by repetitive spike firing. AHP reduction is due to decreased conductance of a calcium-dependent potassium current, the sI(AHP. We have previously shown that learning-induced AHP reduction is maintained by persistent protein kinase C (PKC and extracellular regulated kinase (ERK activation. However, the molecular machinery underlying this long-lasting modulation of intrinsic excitability is yet to be fully described. Here we examine whether the CaMKII, which is known to be crucial in learning, memory and synaptic plasticity processes, is instrumental for the maintenance of learning-induced AHP reduction. KN93, that selectively blocks CaMKII autophosphorylation at Thr286, reduced the AHP in neurons from trained and control rat to the same extent. Consequently, the differences in AHP amplitude and neuronal adaptation between neurons from trained rats and controls remained. Accordingly, the level of activated CaMKII was similar in pirifrom cortex samples taken form trained and control rats. Our data show that although CaMKII modulates the amplitude of AHP of pyramidal neurons in the piriform cortex, its activation is not required for maintaining learning-induced enhancement of neuronal excitability.

  11. Logic of Accounting: The Case of Reporting Previous Options in Norwegian Activation Encounters

    Science.gov (United States)

    Solberg, Janne

    2017-01-01

    The article deals with the enactment of client resistance in Norwegian vocational rehabilitation encounters. More specific, a practice here called "reporting previous options" is analyzed by using the resources of ethnomethodological conversation analysis (CA) in five instances as doing some sort of accounting. In response to the…

  12. Dietary and physical activity behaviors among adults successful at weight loss maintenance

    Directory of Open Access Journals (Sweden)

    Gillespie Cathleen

    2006-07-01

    Full Text Available Abstract Background There is limited population-based data on behavioral factors found to be important for successful weight loss maintenance among adults. Methods Data from the 2004 Styles surveys, mailed to U.S. adults aged ≥18 years were used to examine the difference in selected weight loss strategies and attitudes among persons who reported successful weight loss attempts (lost weight and able to keep it off and persons who were not successful (previous attempts to lose weight were unsuccessful or they could not keep the lost weight off. Behaviors examined included modification of diet, leisure-time and sports activities, and self-monitoring, and barriers to weight management. Results Among adults who reported losing weight or trying to lose weight, 31.0% had been successful at both losing weight and maintenance after weight loss. Successful weight loss status differed by sex, age, and current weight status. Assessment of reported weight loss strategies, found that exercising ≥30 minutes/day and adding physical activity to daily life were significantly higher among successful versus unsuccessful weight losers. Individuals who were successful at weight loss and maintenance were less likely to use over-the-counter diet products than those who were unsuccessful at weight loss. Significantly more successful versus unsuccessful weight losers reported that on most days of the week they planned meals (35.9% vs. 24.9%, tracked calories (17.7% vs. 8.8%, tracked fat (16.4% vs. 6.6%, and measured food on plate (15.9% vs. 6.7%. Successful losers were also more likely to weigh themselves daily (20.3% vs. 11.0%. There were a significantly higher proportion of successful losers who reported lifting weights (19.0% versus unsuccessful (10.9%. The odds of being a successful weight loser were 48%–76% lower for those reporting exercise weight control barriers were influencing factors (e.g., no time, too tired to exercise, no one to exercise with, too

  13. P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells.

    Science.gov (United States)

    Choi, Jinyong; Pease, David Randall; Chen, Siqi; Zhang, Bin; Phee, Hyewon

    2018-01-03

    The p21-activated kinase 2 (Pak2), an effector molecule of the Rho family GTPases Rac and Cdc42, regulates diverse functions of T cells. Previously, we showed that Pak2 is required for development and maturation of T cells in the thymus, including thymus-derived regulatory T (Treg) cells. However, whether Pak2 is required for the functions of various subsets of peripheral T cells, such as naive CD4 and helper T-cell subsets including Foxp3 + Treg cells, is unknown. To determine the role of Pak2 in CD4 T cells in the periphery, we generated inducible Pak2 knockout (KO) mice, in which Pak2 was deleted in CD4 T cells acutely by administration of tamoxifen. Temporal deletion of Pak2 greatly reduced the number of Foxp3 + Treg cells, while minimally affecting the homeostasis of naive CD4 T cells. Pak2 was required for proliferation and Foxp3 expression of Foxp3 + Treg cells upon T-cell receptor and interleukin-2 stimulation, differentiation of in vitro induced Treg cells, and activation of naive CD4 T cells. Together, Pak2 is essential in maintaining the peripheral Treg cell pool by providing proliferation and maintenance signals to Foxp3 + Treg cells. © 2018 The Authors. Immunology Published by John Wiley & Sons Ltd.

  14. Maintenance and decline of physical activity during adolescence: insights from a qualitative study

    Directory of Open Access Journals (Sweden)

    Filion Annie

    2011-10-01

    Full Text Available Abstract Purpose Better knowledge on why some individuals succeed in maintaining participation in physical activity throughout adolescence is needed to guide the development of effective interventions to increase and then maintain physical activity levels. Despite allowing an in-depth understanding, qualitative designs have infrequently been used to study physical activity maintenance. We explored factors contributing to the maintenance and the decline of physical activity during adolescence. Methods Questionnaires were administered to 515 grade 10-12 students. The Physical Activity Questionnaire for Adolescents was used to determine physical activity level at the end of adolescence. An adapted version of this questionnaire was used to estimate physical activity in early adolescence. Among both genders, we identified participants who maintained a high level of physical activity since grade 7 and some whose activity level declined. For each category, groups of 10 students were randomly selected to take part in focus group discussions. Results Seven focus groups with 5 to 8 participants in each were held. Both maintainers and decliners associated physical activity with positive health outcomes. Maintenance of physical activity was associated with supportive social environments and heightened feelings of competence and attractiveness. A decline in physical activity was associated with negative social validation, poor social support and barriers related to access. Conclusions Although maintainers and decliners associate physical activity with similar themes, the experiences of both groups differ substantially with regards to those themes. Taking both perspectives in consideration could help improve interventions to increase and maintain physical activity levels of adolescents.

  15. Remote maintenance design activities and research and development accomplishments for the Compact Ignition Tokamak

    International Nuclear Information System (INIS)

    Spampinato, P.T.

    1988-01-01

    The use of deuterium-tritium (D-T) fuel for the Compact Ignition Tokamak (CIT) requires the use of remote handling technology to carry out maintenance operations. The remote operations consist of removing and replacing such components as first wall armor protection tiles, radio-frequency (rf) heating modules, and diagnostic modules. The major pieces of equipment being developed for maintenance activities internal to the vacuum vessel include an articulated boom manipulator (ABM), an inspection manipulator, and special tooling. For activities external to the vessel, the equipment includes a bridge-mounted manipulator system, decontamination equipment, hot cell equipment, and solid radiation-waste (rad-waste) handling and packaging equipment. The CIT Project is completing the conceptual design phase; research and development (R and D) activities, which include demonstrations of remote maintenance operations on full-size partial mock-ups are under way. 5 figs

  16. The impact of self-efficacy on physical activity maintenance in patients with hip osteoarthritis

    DEFF Research Database (Denmark)

    Hammer, Nanna Maria; Bieler, Theresa; Beyer, Nina Ann-Marie

    2016-01-01

    Purpose: Understanding motivational factors related to physical activity (PA) maintenance is essential in promoting long-term exercise benefits. This study explored the impact of self-efficacy (SE) on post-intervention PA maintenance in patients with hip osteoarthritis. Method: An SE-theory based...... mixed-methods sub-study of a trial investigating the effects of 4 months supervised exercise in patients with hip osteoarthritis. Questionnaire data (n = 52; baseline and 12 months) on PA and SE (Arthritis Self-Efficacy Scale, ASES, score-range 10–100) were analysed (Mann–Whitney test) for differences......-related factors and clinical trial participation appears significant too. •Implications for Rehabilitation •Patients’ perceived self-efficacy for physical activity contributes to the understanding of post-intervention physical activity maintenance in patients with hip osteoarthritis. •Practitioners may benefit...

  17. Effect of intradialytic exercise on daily physical activity and sleep quality in maintenance hemodialysis patients.

    Science.gov (United States)

    Cho, Ji-Hyung; Lee, Ji-Yeon; Lee, Sukyung; Park, Hyuntae; Choi, Seung-Wook; Kim, Jun Chul

    2018-04-01

    Physical inactivity and sleep disturbance are frequently observed and relate to poor clinical outcomes in maintenance hemodialysis patients. We aimed to investigate the effect of intradialytic exercise on daily physical activity and sleep quality, measured by an accelerometer, in maintenance hemodialysis patients. This study randomly assigned ambulatory maintenance hemodialysis patients aged ≥ 20 years on dialysis ≥ 6 months, without a hospitalization history for the previous 3 months to 4 groups: aerobic exercise (AE), resistance exercise (RE), combination exercise (CE), and control. A stationary bike was used for AE and a TheraBand ® /theraball for RE. A 12-week intradialytic exercise program (3 times/week) was completed in the AE (n = 11), RE (n = 10), and CE (n = 12) groups. The control group (n = 13) received only warm-up stretching. At baseline and 12-week follow-up, daily physical activity and sleep quality were measured with a triaxial accelerometer (wActiSleep-BT; ActiGraph, Pensacola, FL) during a continuous 7-day wear period. We observed a significant increase in metabolic equivalent (MET; kcal/h/kg) in the AE (1.02 ± 0.03 vs 1.04 ± 0.04, P = 0.04) and CE (1.06 ± 0.05 vs 1.09 ± 0.08, P = 0.01) groups at 12 weeks compared with baseline. When comparing between-group changes in MET, there was a significant increase in METs in the CE group (0.03 ± 0.03 vs - 0.01 ± 0.04, P = 0.02) compared with the control group. The total number of sedentary bouts (per week) decreased significantly in the AE (200 ± 37 vs 174 ± 36, P = 0.01), RE (180 ± 31 vs 130 ± 49, P = 0.03), and CE groups (180 ± 45 vs 152 ± 46, P = 0.04) at 12 weeks compared with baseline. The average sleep fragmentation index, indicating poor sleep quality, decreased significantly at 12 weeks compared with baseline in the AE (51.4 ± 8.0 vs 44.5 ± 9.6, P = 0.03) and RE groups (52.3 ± 7.3 vs 40.0 ± 15.4, P = 0

  18. Food activities and identity maintenance in old age: a systematic review and meta-synthesis

    OpenAIRE

    Plastow, NA; Atwal, A; Gilhooly, M

    2014-01-01

    Objectives: Services provided to older people should be developed based on active ageing policies. Nutrition is one aspect of active ageing, but little is known about how food activities contribute to psychological well-being in later life. This is a systematic review of qualitative and quantitative research that answers the question What is known about the relationship between food activities and the maintenance of identities in old age?.Methods: We followed the preferred reporting items for...

  19. Opportunities and supporting activities to promote preventive maintenance of NPPs in Japan

    International Nuclear Information System (INIS)

    Sanada, A.; Shinkawa, T.; Sakurada, M.

    1998-01-01

    With increase of the number of NPPs and operation history, enhancement of the safety regulation is becoming important for such long-operated NPPs. Centering on the comprehensive preventive maintenance, periodic safety reviews by utilities and its review and evaluation by MITI are in progress. The first reviews have not revealed essential and critical indications to be newly implemented. This means that the most of activities to secure reliability and safety have been done steadily. The present paper addresses the mechanism of on-going preventive maintenance and its essential elements: opportunities to identify issues and problems, and supporting activities to promote decision-makings on feedback, upgrading and modernization of NPPs. (author)

  20. Prevalence and risk factors of previous or active Hepatitis B infection ...

    African Journals Online (AJOL)

    Background: Hepatitis B Virus (HBV) and HIV spread in the same manner, but HBV is more infectious than HIV-1. Active HBV requires modification of HIV-1 therapy and is associated with increased risk for sexual transmission of HBV. Objective: To determine the prevalence and knowledge of HBV among HIV-1 discordant ...

  1. Dynamics of ozone layer under Serbia and solar activity: Previous statement

    Directory of Open Access Journals (Sweden)

    Ducić Vladan

    2008-01-01

    Full Text Available The aim of this paper is to identify ozone layer dynamics under Serbian area, as well as possible relations of change in stratospheric ozone concentration with some parameters of solar activity. During the period 1979-2005, the statistical decrease of ozone concentration was noticed under Serbian territory cumulatively for 24.5 DU (7.2%, apropos 9.4 DU (2.8% by decade. These changes are consistent with the changes in surrounding countries. From absolute minimum 1993, flexible trend of ozone layer pentad values validate hypotheses of its recovery. Correspondence of ozone thickness extreme period with Wolf's number and with the greatest volcanic eruptions shows that interannual variations of stratospheric ozone concentration are still in the function of natural factors above all, as are solar and volcanic activities. Investigation of larger number solar activity parameters shows statistically important antiphase synchronous between the number of polar faculae on the Sun and stratospheric ozone dynamics under Serbia. Respecting that relation between these two features until now isn't depicted, some possible causal mechanisms are proposed.

  2. Designing Interventions that Last: A Classification of Environmental Behaviors in Relation to the Activities, Costs, and Effort Involved for Adoption and Maintenance

    Directory of Open Access Journals (Sweden)

    Harriet E. Moore

    2017-11-01

    Full Text Available Policy makers draw on behavioral research to design interventions that promote the voluntary adoption of environmental behavior in societies. Many environmental behaviors will only be effective if they are maintained over the long-term. In the context of climate change and concerns about future water security, behaviors that involve reducing energy consumption and improving water quality must be continued indefinitely to mitigate global warming and preserve scarce resources. Previous reviews of environmental behavior have focused exclusively on factors related to adoption. This review investigates the factors that influence both adoption and maintenance, and presents a classification of environmental behaviors in terms of the activities, costs, and effort required for both adoption and maintenance. Three categories of behavior are suggested. One-off behaviors involve performing an activity once, such as purchasing an energy efficient washing machine, or signing a petition. Continuous behaviors involve the performance of the same set of behaviors for adoption and for maintenance, such as curbside recycling. Dynamic behaviors involve the performance of different behaviors for adoption and maintenance, such as revegetation. Behaviors can also be classified into four categories related to cost and effort: those that involve little cost and effort for adoption and maintenance, those that involve moderate cost and effort for adoption and maintenance, those that involve a high cost or effort for adoption and less for maintenance, and those that involve less cost or effort for adoption and a higher amount for maintenance. In order to design interventions that last, policy makers should consider the factors that influence the maintenance as well as the adoption of environmental behaviors.

  3. Maintenance: organizational modes, activities and health and safety. Use of a French national survey and in-situ analyses.

    Science.gov (United States)

    Grusenmeyer, Corinne

    2014-12-01

    Maintenance activities are identified as critical both to operator safety and to systems safety and reliability. However, it is still difficult to identify maintenance workers in French occupational accident and disease statistics. Moreover, few analyses of these activities and of organizational changes in this field have been conducted. This paper presents two different approaches to this same issue. Analyses were aimed firstly at identifying the occupational exposures of these operators and at comparing them with occupational exposures of production staff and, secondly at developing understanding of normal real maintenance activities, i.e. maintenance activities that are normally actually carried out, while taking into account the socio-technical system and maintenance organization within which they lie. The use of the French SUMER 2003 survey shows that occupational exposures of maintenance staff to various constraints are more frequent than occupational exposures of their production colleagues. However, maintenance staff appear to have greater independence. Analyses were also conducted in a subcontracting urban public transport company, who outsources some maintenance work. Those analyses highlight a complex network of companies involved in maintenance activities, a substantial number of work interruptions and a significant fragmentation of the internal technicians' activities that can be cognitively costly, reduce anticipation possibilities and lead to incidents or accidents. Above all they underline internal technicians' contributions to the completion of outsourced interventions and interdependent relationships between the activities of the internal and the external technicians. Outsourcing maintenance interventions thus raises the question of risks associated with the interdependence of actual work activities undertaken by the different types of staff, since they contribute to the same maintenance intervention. This study therefore pinpoints the need to

  4. Relationship between volition, physical activity and weight loss maintenance: Study rationale, design, methods and baseline characteristics.

    Science.gov (United States)

    Dandanell, Sune; Elbe, Anne-Marie; Pfister, Gertrud; Elsborg, Peter; W Helge, Jørn

    2017-05-01

    To investigate the relationship between volition, physical activity and weight loss maintenance. We recruited 84 sedentary (maximal oxygen uptake: 25 ± 5 ml/min), overweight and obese (Body mass index (BMI) 38 ± 7 m/h 2 , fat 44 ± 7 %) women ( n = 55) and men ( n = 29) for an interdisciplinary prospective study with follow-up. The change in lifestyle and weight loss is promoted via a 3-month intensive lifestyle intervention at a private health school. The intervention consists of supervised training (1-3 hours/day), a healthy hypo-caloric diet (-500 to -700 kCal/day) and education in healthy lifestyle in classes/groups. The participants' body weight and composition (Dual Energy X-ray absorptiometry), volitional skills (questionnaire), physical activity level (heart rate accelerometer/questionnaire) and maximal oxygen uptake (indirect calorimetry) are to be monitored before, after, and 3 and 12 months after the intervention. At the 12-month follow-up, three different groups will be established: Clinical weight loss maintenance (> 10% weight loss from baseline), moderate weight loss maintenance (1-10% weight loss) and no weight loss (or weight regain). A linear mixed model analysis will be used to compare levels of volitional skills, physical activity and maximal oxygen uptake over time, between the three groups. Correlational analyses will be used to investigate possible associations between volition, maximal oxygen uptake, physical activity level and weight loss maintenance. If specific volitional skills are identified as predictors of adherence to physical activity and success in clinical weight loss maintenance, these can be trained in future intensive lifestyle interventions in order to optimize the success rate.

  5. An fMRI study of neuronal activation in schizophrenia patients with and without previous cannabis use

    Directory of Open Access Journals (Sweden)

    Else-Marie eLøberg

    2012-10-01

    Full Text Available Previous studies have mostly shown positive effects of cannabis use on cognition in patients with schizophrenia, which could reflect lower neurocognitive vulnerability. There are however no studies comparing whether such cognitive differences have neuronal correlates. Thus, the aim of the present study was to compare whether patients with previous cannabis use differ in brain activation from patients who has never used cannabis. The patients groups were compared on the ability to up-regulate an effort mode network during a cognitive task and down-regulate activation in the same network during a task-absent condition. Task-present and task-absent brain activation was measured by functional magnetic resonance neuroimaging (fMRI. Twenty-six patients with a DSM-IV and ICD-10 diagnosis of schizophrenia were grouped into a previous cannabis user group and a no-cannabis group. An auditory dichotic listening task with instructions of attention focus on either the right or left ear stimulus was used to tap verbal processing, attention and cognitive control, calculated as an aggregate score. When comparing the two groups, there were remaining activations in the task-present condition for the cannabis group, not seen in the no-cannabis group, while there was remaining activation in the task-absent condition for the no-cannabis group, not seen in the cannabis group. Thus, the patients with previous cannabis use showed increased activation in an effort mode network and decreased activation in the default mode network as compared to the no-cannabis group. It is concluded that the present study show some differences in brain activation to a cognitively challenging task between previous cannabis and no-cannabis schizophrenia patients.

  6. Relationship between volition, physical activity and weight loss maintenance: Study rationale, design, methods and baseline characteristics

    DEFF Research Database (Denmark)

    Dandanell, Sune; Elbe, Anne-Marie; Pfister, Gertrud Ursula

    2017-01-01

    Aims: To investigate the relationship between volition, physical activity and weight loss maintenance. Methods: We recruited 84 sedentary (maximal oxygen uptake: 25 ± 5 ml/min), overweight and obese (Body mass index (BMI) 38 ± 7 m/h2, fat 44 ± 7 %) women (n = 55) and men (n = 29) for an interdisc......Aims: To investigate the relationship between volition, physical activity and weight loss maintenance. Methods: We recruited 84 sedentary (maximal oxygen uptake: 25 ± 5 ml/min), overweight and obese (Body mass index (BMI) 38 ± 7 m/h2, fat 44 ± 7 %) women (n = 55) and men (n = 29......) for an interdisciplinary prospective study with follow-up. The change in lifestyle and weight loss is promoted via a 3-month intensive lifestyle intervention at a private health school. The intervention consists of supervised training (1–3 hours/day), a healthy hypo-caloric diet (−500 to −700 kCal/day) and education...... maintenance. Conclusions: If specific volitional skills are identified as predictors of adherence to physical activity and success in clinical weight loss maintenance, these can be trained in future intensive lifestyle interventions in order to optimize the success rate....

  7. Effects of functional physical activity on the maintenance of motor function in Alzheimer’s disease

    OpenAIRE

    Fajersztajn, Laís; Cordeiro, Renata Cereda; Andreoni, Solange; Garcia, Jacqueline Takayanagi

    2008-01-01

    Abstract It is widely known that older adults, even frail individuals, can improve their physical function using appropriately targeted exercise. Nevertheless, older adults with Alzheimer's disease (AD) have been excluded from the majority of studies on exercise. The functional-task physical activity program is based on activities of daily living, and may be suited for elderly people with AD because it focuses on the maintenance and stimulation of preserved abilities. In addition, session cos...

  8. Financial Motivation Undermines Maintenance in an Intensive Diet and Activity Intervention

    Directory of Open Access Journals (Sweden)

    Arlen C. Moller

    2012-01-01

    Full Text Available Financial incentives are widely used in health behavior interventions. However, self-determination theory posits that emphasizing financial incentives can have negative consequences if experienced as controlling. Feeling controlled into performing a behavior tends to reduce enjoyment and undermine maintenance after financial contingencies are removed (the undermining effect. We assessed participants’ context-specific financial motivation to participate in the Make Better Choices trial—a trial testing four different strategies for improving four health risk behaviors: low fruit and vegetable intake, high saturated fat intake, low physical activity, and high sedentary screen time. The primary outcome was overall healthy lifestyle change; weight loss was a secondary outcome. Financial incentives were contingent upon meeting behavior goals for 3 weeks and became contingent upon merely providing data during the 4.5-month maintenance period. Financial motivation for participation was assessed at baseline using a 7-item scale (=.97. Across conditions, a main effect of financial motivation predicted a steeper rate of weight regained during the maintenance period, (165=2.15, =.04. Furthermore, financial motivation and gender interacted significantly in predicting maintenance of healthy diet and activity changes, (160=2.42, =.016, such that financial motivation had a more deleterious influence among men. Implications for practice and future research on incentivized lifestyle and weight interventions are discussed.

  9. Review on Japanese activities in the field of maintenance and repair of LMFBR steam generators

    International Nuclear Information System (INIS)

    Tsuchiya, T.; Fukuda, T.; Sato, M.; Okabayashi, K.; Takahashi, T.

    2002-01-01

    Summary of Japanese activities on maintenance and repair of LMFBR steam generators (SG) is described in this paper. The concept (adoption of helical coil tube etc.) of MONJU SG was established in conceptional design started from 1968, and research and development (R and D) program was prepared. Parallel with basic studies such as material, welding, sodium water reaction and etc., overall verification tests using mock up SGs were conducted. As the first step, 1 Mw SG with two active helical tubes (and eight dummy tubes) was fabricated and operated, and many maintenance and repair experiences were accumulated through two small water leak troubles. Two 50Mw SGs, 1/5 scale of MONJU SG, were constructed and operated for long time. Post test examinations were carried out for No.1 50 Mw SG and feasibility of this type of SG was confirmed. In regard to maintenance and repair techniques, explosive and welding method for tube plugging and UT and ECT techniques for inspection of tube integrity are under development. Overall verification test for on-site and in-factory maintenance and repair techniques was conducted using No.2 50Mw SG evaporator and applicability of those techniques to real plant was evaluated. Many experiences were accumulated for removal and cleaning of sodium water reaction products after sodium water reaction in the cooling system and pressure relief system, using the Large Sodium Water Reaction Test Facility (SWAT-1 and 3). (author)

  10. The Role of Exercise and Physical Activity in Weight Loss and Maintenance

    OpenAIRE

    Swift, Damon L.; Johannsen, Neil M.; Lavie, Carl J.; Earnest, Conrad P.; Church, Timothy S.

    2013-01-01

    This review explores the role of physical activity (PA) and exercise training (ET) in the prevention of weight gain, initial weight loss, weight maintenance, and the obesity paradox. In particular, we will focus the discussion on the expected initial weight loss from different ET programs, and explore intensity/volume relationships. Based on the present literature, unless the overall volume of aerobic ET is very high, clinically significant weight loss is unlikely to occur. Also, ET also has ...

  11. Neutron induced activation in the EVEDA accelerator materials: Implications for the accelerator maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sanz, J. [Department of Power Engineering, Universidad Nacional de Educacion a Distancia (UNED), C/Juan del Rosal 12, 28040 Madrid (Spain); Institute of Nuclear Fusion, UPM, 28006 Madrid (Spain)], E-mail: jsanz@ind.uned.es; Garcia, M.; Sauvan, P.; Lopez, D. [Department of Power Engineering, Universidad Nacional de Educacion a Distancia (UNED), C/Juan del Rosal 12, 28040 Madrid (Spain); Institute of Nuclear Fusion, UPM, 28006 Madrid (Spain); Moreno, C.; Ibarra, A.; Sedano, L. [CIEMAT, 28040 Madrid (Spain)

    2009-04-30

    The Engineering Validation and Engineering Design Activities (EVEDA) phase of the International Fusion Materials Irradiation Facility project should result in an accelerator prototype for which the analysis of the dose rates evolution during the beam-off phase is a necessary task for radioprotection and maintenance feasibility purposes. Important aspects of the computational methodology to address this problem are discussed, and dose rates for workers inside the accelerator vault are assessed and found to be not negligible.

  12. Neutron induced activation in the EVEDA accelerator materials: Implications for the accelerator maintenance

    International Nuclear Information System (INIS)

    Sanz, J.; Garcia, M.; Sauvan, P.; Lopez, D.; Moreno, C.; Ibarra, A.; Sedano, L.

    2009-01-01

    The Engineering Validation and Engineering Design Activities (EVEDA) phase of the International Fusion Materials Irradiation Facility project should result in an accelerator prototype for which the analysis of the dose rates evolution during the beam-off phase is a necessary task for radioprotection and maintenance feasibility purposes. Important aspects of the computational methodology to address this problem are discussed, and dose rates for workers inside the accelerator vault are assessed and found to be not negligible.

  13. Determinants of Physical Activity Maintenance in Breast Cancer Survivors After a Community-Based Intervention.

    Science.gov (United States)

    Lee, C Ellen; Von Ah, Diane; Szuck, Beth; Lau, Yiu-Keung James

    2016-01-01

    To determine whether empirically selected and social cognitive theory-based factors, including baseline characteristics and modifiable behavioral and psychosocial factors, were determinants of physical activity (PA) maintenance in breast cancer survivors (BCSs) six months after a PA intervention.
. Single-group longitudinal study.
. The Breast Health Centre in Winnipeg, Manitoba, Canada.
. 42 survivors with stage 0-III breast cancer who completed chemotherapy and/or radiation therapy.
. The community-based PA intervention included six weekly education and practice sessions on home-based aerobic, resistance, balance, and flexibility exercises.
. The dependent variable, PA maintenance, was determined based on PA level measurement at six months postintervention. The independent variables of baseline characteristics (age, stage of cancer, and chronic musculoskeletal symptoms) and modifiable behavioral and psychosocial factors (PA level, fatigue, PA self-efficacy in overcoming barriers and performing tasks) were assessed at baseline and postintervention.
. Multivariate regression analyses revealed that baseline fatigue and chronic musculoskeletal symptoms were the only factors significantly associated with PA maintenance.
. Baseline fatigue level and chronic musculoskeletal symptoms were significant determinants of PA maintenance in breast cancer survivors who had completed a community-based PA intervention. However, other key factors were considered.
. Prior to participation in community-based PA interventions, clinicians should take into account the effects of high baseline fatigue levels and chronic musculoskeletal symptoms on potential PA maintenance, and consider additional assessments and support for BCSs to sustain their PA behavioral change.
.

  14. Activation of two forms of locomotion by a previously identified trigger interneuron for swimming in the medicinal leech.

    Science.gov (United States)

    Brodfuehrer, Peter D; McCormick, Kathryn; Tapyrik, Lauren; Albano, Alfonso M; Graybeal, Carolyn

    2008-03-01

    Higher-order projection interneurons that function in more than one behavior have been identified in a number of preparations. In this study, we document that stimulation of cell Tr1, a previously identified trigger interneuron for swimming in the medicinal leech, can also elicit the motor program for crawling in isolated nerve cords. We also show that motor choice is independent of the firing frequency of Tr1 and amount of spiking activity recorded extracellularly at three locations along the ventral nerve cord prior to Tr1 stimulation. On the other hand, during Tr1 stimulation there is a significant difference in the amount of activity elicited in the ventral nerve cord that correlates with the motor program activated. On average, Tr1 stimulation trials that lead to crawling elicit greater amounts of activity than in trials that lead to swimming.

  15. How Are Previous Physical Activity and Self-Efficacy Related to Future Physical Activity and Self-Efficacy?

    Science.gov (United States)

    David, Prabu; Pennell, Michael L.; Foraker, Randi E.; Katz, Mira L.; Buckworth, Janet; Paskett, Electra D.

    2014-01-01

    Self-efficacy (SE) has been found to be a robust predictor of success in achieving physical activity (PA) goals. While much of the current research has focused on SE as a trait, SE as a state has received less attention. Using day-to-day measurements obtained over 84 days, we examined the relationship between state SE and PA. Postmenopausal women…

  16. 77 FR 70846 - Regulatory Guide 1.182, “Assessing and Managing Risk Before Maintenance Activities at Nuclear...

    Science.gov (United States)

    2012-11-27

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0285] Regulatory Guide 1.182, ``Assessing and Managing Risk Before Maintenance Activities at Nuclear Power Plants'' AGENCY: Nuclear Regulatory Commission... withdrawing Regulatory Guide (RG)1.182, Revision (Rev.) 0, ``Assessing and Managing Risk Before Maintenance...

  17. Business process modeling of industrial maintenance at TRANSPETRO: integrating oil pipeline and marine terminals activities

    Energy Technology Data Exchange (ETDEWEB)

    Arruda, Daniela Mendonca; Oliveira, Italo Luiz [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil). Diretoria de Terminais e Oleodutos; Almeida, Maria Fatima Ludovico de [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ (Brazil). Programa de Pos-Graduacao em Metrologia para Qualidade e Inovacao

    2009-07-01

    This paper describes the experience of TRANSPETRO in remodeling industrial maintenance activities focusing on: preparing for business process modeling (BPM); mapping and analyzing 'As-Is' process; designing 'To-Be' process; implementing remodeled process; improving process continuously. The conceptual model and results achieved will contribute to several areas within the company as: reliability engineering; human resources, including employees' selective processes, training and development, and certifications; standardization process encompassing standard and operational procedures adoption according to up-dating external normative references and legal requirements; health, safety and environment (HSE) performance improvement. These are some of potential benefits from BPM focusing on TRANSPETRO's industrial maintenance area in the search of operational excellence. (author)

  18. Maintenance oriented tokamak reactor with low activation material and high aspect ratio configuration

    International Nuclear Information System (INIS)

    Nishio, S.; Ueda, S.; Aoki, I.

    1997-01-01

    Some of the difficulties of maintenance of a tokamak system are due to the radioactivity of its materials and the complexity of its configuration. To mitigate the difficulties, very low activation SiC/SiC composite material and a torus configuration with a high aspect ratio of eight are introduced. The torus system is divided radially into equal sectors, each of which forms an assembling unit. All piping and feeder systems are shifted to the spacious central torus region. The new concept is called DREAM tokamak reactor, which is an acronym for DRastically EAsy Maintenance. The maximum toroidal field strength of 20 T and the plasma major and minor radii of 16 m and 2 m lead to a high fusion power of 5.5 GW, under moderate physics constraints such as an MHD safety factor of three, a Troyon factor of three for the beta limit and an energy confinement time enhancement factor of two. (author)

  19. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

    Science.gov (United States)

    van Oers, Johanna M. M.; Roa, Sergio; Werling, Uwe; Liu, Yiyong; Genschel, Jochen; Sellers, Rani S.; Modrich, Paul; Scharff, Matthew D.; Edelmann, Winfried

    2010-01-01

    The DNA mismatch repair protein PMS2 was recently found to encode a novel endonuclease activity. To determine the biological functions of this activity in mammals, we generated endonuclease-deficient Pms2E702K knock-in mice. Pms2EK/EK mice displayed increased genomic mutation rates and a strong cancer predisposition. In addition, class switch recombination, but not somatic hypermutation, was impaired in Pms2EK/EK B cells, indicating a specific role in Ig diversity. In contrast to Pms2−/− mice, Pms2EK/EK male mice were fertile, indicating that this activity is dispensable in spermatogenesis. Therefore, the PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance and tumor suppression. PMID:20624957

  20. The relationship between physical activity, volitional skills and weight loss maintenance in Danish obese individuals

    DEFF Research Database (Denmark)

    Elsborg, Peter; Pfister, Gertrud Ursula; Helge, Jørn Wulff

    . However, the relationship between weight loss maintenance and volitional skills has not been investigated yet. This study investigates if volitional skills are related to the amount of physical activity in obese individuals, and their relationship with actual successful weight loss. Methods: Participants......-confidence and coping with failure and lower values in lack of energy, postponing training, and avoiding effort than unsuccessful weight maintainers. Furthermore, the successful were significantly more physically active. Higher physical activity was related to higher positive lower negative values in a total of 9...... course are discussed. Conflict of Interest: None to declare. Funding The study is supported by the research programme "Physical activity and nutrition for improvement of health" funded by the University of Copenhagen Excellence Programme for Interdisciplinary Research....

  1. Previously undescribed plasmids recovered from activated sludge confer tetracycline resistance and phenotypic changes to Acinetobacter oleivorans DR1.

    Science.gov (United States)

    Hong, Hyerim; Ko, Hyeok-Jin; Choi, In-Geol; Park, Woojun

    2014-02-01

    We used culture-dependent and culture-independent methods to extract previously undescribed plasmids harboring tetracycline (TC) resistance genes from activated sludge. The extracted plasmids were transformed into naturally competent Acinetobacter oleivorans DR1 to recover a non-Escherichia coli-based plasmid. The transformed cells showed 80-100-fold higher TC resistance than the wild-type strain. Restriction length polymorphism performed using 30 transformed cells showed four different types of plasmids. Illumina-based whole sequencing of the four plasmids identified three previously unreported plasmids and one previously reported plasmid. All plasmids carried TC resistance-related genes (tetL, tetH), tetracycline transcriptional regulators (tetR), and mobilization-related genes. As per expression analysis, TC resistance genes were functional in the presence of TC. The recovered plasmids showed mosaic gene acquisition through horizontal gene transfer. Membrane fluidity, hydrophobicity, biofilm formation, motility, growth rate, sensitivity to stresses, and quorum sensing signals of the transformed cells were different from those of the wild-type cells. Plasmid-bearing cells seemed to have an energy burden for maintaining and expressing plasmid genes. Our data showed that acquisition of TC resistance through plasmid uptake is related to loss of biological fitness. Thus, cells acquiring antibiotic resistance plasmids can survive in the presence of antibiotics, but must pay ecological costs.

  2. Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ren; Nelson, Celeste M.; Muschler, John L.; Veiseh, Mandana; Vonderhaar, Barbara K.; Bissell, Mina J.

    2009-06-03

    Epithelial cells, once dissociated and placed in two-dimensional (2D) cultures, rapidly lose tissue-specific functions. We showed previously that in addition to prolactin, signaling by laminin-111 was necessary to restore functional differentiation of mammary epithelia. Here, we elucidate two additional aspects of laminin-111 action. We show that in 2D cultures, the prolactin receptor is basolaterally localized and physically segregated from its apically placed ligand. Detachment of the cells exposes the receptor to ligation by prolactin leading to signal transducers and activators of transcription protein 5 (STAT5) activation, but only transiently and not sufficiently for induction of milk protein expression. We show that laminin-111 reorganizes mammary cells into polarized acini, allowing both the exposure of the prolactin receptor and sustained activation of STAT5. The use of constitutively active STAT5 constructs showed that the latter is necessary and sufficient for chromatin reorganization and {beta}-casein transcription. These results underscore the crucial role of continuous laminin signaling and polarized tissue architecture in maintenance of transcription factor activation, chromatin organization, and tissue-specific gene expression.

  3. Food activities and identity maintenance in old age: a systematic review and meta-synthesis.

    Science.gov (United States)

    Plastow, Nicola Ann; Atwal, Anita; Gilhooly, Mary

    2015-01-01

    Services provided to older people should be developed based on active ageing policies. Nutrition is one aspect of active ageing, but little is known about how food activities contribute to psychological well-being in later life. This is a systematic review of qualitative and quantitative research that answers the question 'What is known about the relationship between food activities and the maintenance of identities in old age?'. We followed the preferred reporting items for systematic reviews and meta-analyses guidelines and used quality assessment parameters to complete a systematic review and narrative synthesis. Academic Search Premier, MEDLINE, CINAHL Plus, and PsycINFO databases were searched. We initially identified 8016 articles, of which 167 full-text articles were screened for inclusion. Twenty-two articles were included in the review. There was moderate evidence from nine qualitative and two quantitative studies, of variable quality, that food activities contribute to the maintenance of women's gendered identities, the ethnic identities of men and women, and community identities. There was moderate evidence from 10 qualitative studies, of variable quality, that a change in food choice and deteriorating health changed food activity participation. These changes threatened identities. Most studies included both younger adults and older adults. In later life, there are many life experiences leading to change. Further research is needed to develop understanding of how identity and mental well-being are maintained, despite changes in everyday activities like cooking and eating. This may enable health care professionals to meet psychological needs alongside biological needs during nutritional interventions.

  4. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

    DEFF Research Database (Denmark)

    Scott, Robert A; Chu, Audrey Y; Grarup, Niels

    2012-01-01

    to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were...... dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (ß = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were...... associated with 2-h glucose (ß = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated...

  5. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  6. Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy.

    Science.gov (United States)

    Heo, Mi Hwa; Kim, Hee Kyung; Lee, Hansang; Kim, Ji-Yeon; Ahn, Jin-Seok; Im, Young-Hyuck; Park, Yeon Hee

    2018-03-16

    We conducted a retrospective analysis of the clinical activity of fulvestrant in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) previously treated with endocrine therapy and/or chemotherapy. We reviewed the medical records of all patients with MBC treated at Samsung Medical Center between January 2009 and August 2016. Patients received fulvestrant 250 mg intramuscularly every 28 days (from January 2009 to November 2010) or 500 mg intramuscularly every 28 days (from December 2010 to August 2016). Tumor responses were assessed every 8 weeks and at the end of treatment, as well as when disease progression was suspected. A total of 84 patients were included in this study. A median of two previous endocrine treatments had been performed; 79% of the patients had received two or more endocrine treatments. Forty-five patients (54%) had been treated with chemotherapy for MBC before the fulvestrant treatment course. Visceral metastasis was found in 49 patients (58%). The estimated median progression-free survival and overall survival were 4.4 months (95% confidence interval [CI], 3.4 to 5.5) and 32.5 months (95% CI, 17.6 to 47.4), respectively. The disease control rate was 40.5% (95% CI, 30.5 to 51.5); partial response was observed in 16% of the patients and stable disease was observed in 25% of the patients. The most frequently reported adverse reactions were mild-to-moderate grade myalgia (10.5% of the patients), injection site pain (7%), and fatigue (7%). Fulvestrant was generally well tolerated. Fulvestrant showed encouraging clinical activity and favorable feasibility in postmenopausal women with MBC who had been treated with multiple endocrine therapies and/or cytotoxic chemotherapies.

  7. A new approach to physical activity maintenance: Rationale, design, and baseline data from the Keep Active Minnesota trial

    Directory of Open Access Journals (Sweden)

    Crain A Lauren

    2008-07-01

    Full Text Available Abstract Background Since many individuals who initiate physical activity programs are highly likely to return to a sedentary lifestyle, innovative strategies to efforts to increase the number of physically active older adults who successfully maintain beneficial levels of PA for a substantial length of time are needed. Methods/Design The Keep Active Minnesota Trial is a randomized controlled trial of an interactive phone- and mail-based intervention to help 50–70 year old adults who have recently increased their physical activity level, maintain that activity level over a 24-month period in comparison to usual care. Baseline, 6, 12, and 24 month measurement occurred via phone surveys with kilocalories expended per week in total and moderate-to-vigorous physical activity (CHAMPS Questionnaire as the primary outcome measures. Secondary outcomes include hypothesized mediators of physical activity change (e.g., physical activity enjoyment, self-efficacy, physical activity self-concept, body mass index, and depression. Seven day accelerometry data were collected on a sub-sample of participants at baseline and 24-month follow-up. Discussion The Keep Active Minnesota study offers an innovative approach to the perennial problem of physical activity relapse; by focusing explicitly on physical activity maintenance, the intervention holds considerable promise for modifying the typical relapse curve. Moreover, if shown to be efficacious, the use of phone- and mail-based intervention delivery offers potential for widespread dissemination. Trial registration ClinicalTrials.gov Identifier: NCT00283452.

  8. Motives for physical activity in the adoption and maintenance of physical activity in men with alcohol use disorders.

    Science.gov (United States)

    Vancampfort, Davy; Van Damme, Tine; Probst, Michel; Vandael, Hannelore; Hallgren, Mats; Mutamba, Byamah Brian; Nabanoba, Justine; Basangwa, David; Mugisha, James

    2018-03-01

    Within the self-determination theory and the trans-theoretical model (stages of change) frameworks, we investigated motives for physical activity adoption and maintenance in men with alcohol use disorder (AUD). Fifty Ugandan patients completed the Behavioral Regulation in Exercise Questionnaire-3 (BREQ-3) to assess exercise motives, the Patient-centred Assessment and Counselling for Exercise (PACE) to determine stage of change and the Alcohol Use Disorders Identification Test. The relationship between motives for physical activity and stage of change was investigated using ANOVA with post-hoc Scheffe tests. Multivariate analyses found significantly higher levels of introjected, identified and integrated motivation in the action and maintenance stage versus the pre-action stage. There were no differences in intrinsic motivation between the stages of change. Our results suggest that in order to adopt and maintain an active lifestyle the most important source of motivation comes from the benefits that may be obtained rather than from the inherent pleasure or challenge associated with it. The study provides a platform for future research to investigate the importance of autonomous motivation within physical activity interventions for people with AUD. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. PWSCC Preventive Maintenance Activities for Alloy 600 in Japanese PWR Plants

    International Nuclear Information System (INIS)

    Yamamoto, K.; Sugimoto, N.; Onishi, K.; Okimura, K.

    2012-01-01

    Because many nuclear plants have been in operation for ages, the importance of preventive maintenance technologies is getting higher. One conspicuous problem found in pressurized water reactor (PWR) plants is the primary water stress corrosion cracking (PWSCC) observed in Alloy 600 (a kind of high nickel based alloy) parts. Alloy 600 was used for butt welds between low alloy steel and stainless steel of nozzles of Reactor Vessel (RV), Steam Generator (SG), and Pressurizer (Pz). As PWSCC occurred at these parts may cause Loss of Coolant Accident (LOCA), preventive maintenance is necessary. PWSCC is considered to be caused by a mixture of three elements: high residual tensile stress on surface, material (Alloy 600) and environment. PWSCC can be prevented by improving one of the elements. MHI has been developing stress improvement methods, for example, Water Jet Peening (WJP), Shot Peening by Ultrasonic vibration (USP), and Laser Stress Improvement Process (L-SIP). According to the situation, appropriate method is applied for each part. WJP has been applied for RV nozzles of a lot of plants in Japan. However PWSCC was observed in RV nozzles during the inspection before WJP in recent years, MHI developed the Advanced INLAY system to improve the material from Alloy 600 to Alloy 690. Alloy 600 on the inner surface of the nozzles is removed and welding with Alloy 690 is performed. In addition, heat treatments for the nozzles are difficult for its structural situation, so ambient temperature temper bead welding technique for RV nozzles was developed to make the heat treatments unnecessary. This paper describes countermeasures against PWSCC and introduces the maintenance activities performed in Japan. (author)

  10. The role of exercise and physical activity in weight loss and maintenance.

    Science.gov (United States)

    Swift, Damon L; Johannsen, Neil M; Lavie, Carl J; Earnest, Conrad P; Church, Timothy S

    2014-01-01

    This review explores the role of physical activity (PA) and exercise training (ET) in the prevention of weight gain, initial weight loss, weight maintenance, and the obesity paradox. In particular, we will focus the discussion on the expected initial weight loss from different ET programs, and explore intensity/volume relationships. Based on the present literature, unless the overall volume of aerobic ET is very high, clinically significant weight loss is unlikely to occur. Also, ET also has an important role in weight regain after initial weight loss. Overall, aerobic ET programs consistent with public health recommendations may promote up to modest weight loss (~2 kg), however the weight loss on an individual level is highly heterogeneous. Clinicians should educate their patients on reasonable expectations of weight loss based on their physical activity program and emphasize that numerous health benefits occur from PA programs in the absence of weight loss. © 2014.

  11. Explaining Physical Activity Maintenance After a Theory-Based Intervention Among Patients With Rheumatoid Arthritis: Process Evaluation of a Randomized Controlled Trial.

    Science.gov (United States)

    Knittle, Keegan; De Gucht, Véronique; Hurkmans, Emalie; Vlieland, Thea Vliet; Maes, Stan

    2016-02-01

    Regular physical activity (PA) benefits patients with rheumatoid arthritis (RA), particularly when maintained over time. Research in this area has largely focused on factors associated with initiating PA, while factors contributing to PA maintenance, particularly after lifestyle interventions, have received less attention. This study examined whether higher levels of autonomous motivation, self-efficacy for PA, and greater use of self-regulation skills mediated PA initiation and maintenance 6 months after a theory-based motivational interviewing and self-regulation coaching intervention. Seventy-eight individuals with RA were randomized to receive either a patient-education session (control group), or the patient-education session plus 1 motivational interview and 2 self-regulation coaching sessions (treatment group). Mediation analyses examined the effects of this intervention on PA initiation and maintenance through the intermediate variables autonomous motivation, self-efficacy for PA, and use of self-regulation skills. Analyses were controlled for age, sex, and previous levels of PA. The treatment group reported significantly higher autonomous motivation and greater use of self-regulation skills than controls at posttreatment. Increases in PA from baseline to posttreatment were not mediated by any intermediate variables. However, maintenance of PA from posttreatment to followup (6 months later) was mediated by greater autonomous motivation and use of self-regulation skills. Greater autonomous motivation and use of self-regulation skills predict maintenance of PA following a motivational interviewing and self-regulation coaching intervention. In promoting PA among patients with RA, supporting patient autonomy and teaching self-regulation skills, which focus attention on achieving PA goals, may improve long-term maintenance of PA. © 2016, American College of Rheumatology.

  12. Persistent recruitment of somatosensory cortex during active maintenance of hand images in working memory.

    Science.gov (United States)

    Galvez-Pol, A; Calvo-Merino, B; Capilla, A; Forster, B

    2018-03-13

    Working memory (WM) supports temporary maintenance of task-relevant information. This process is associated with persistent activity in the sensory cortex processing the information (e.g., visual stimuli activate visual cortex). However, we argue here that more multifaceted stimuli moderate this sensory-locked activity and recruit distinctive cortices. Specifically, perception of bodies recruits somatosensory cortex (SCx) beyond early visual areas (suggesting embodiment processes). Here we explore persistent activation in processing areas beyond the sensory cortex initially relevant to the modality of the stimuli. Using visual and somatosensory evoked-potentials in a visual WM task, we isolated different levels of visual and somatosensory involvement during encoding of body and non-body-related images. Persistent activity increased in SCx only when maintaining body images in WM, whereas visual/posterior regions' activity increased significantly when maintaining non-body images. Our results bridge WM and embodiment frameworks, supporting a dynamic WM process where the nature of the information summons specific processing resources. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. 2011 Operations and Maintenance Activities in the East Region of UNAVCO's Plate Boundary Observatory

    Science.gov (United States)

    Dittmann, T.; Feaux, K.; Kasmer, D.; Jenkins, F.; Mencin, D.

    2011-12-01

    2011 marked Year 3 of Operations and Maintenance of the Plate Boundary Observatory (PBO). In the East Region of PBO, it was a year characterized by several major projects as well as scheduled ongoing maintenance activities. The most significant major project was a USGS/ARRA funded communications upgrade in Yellowstone National Park. This upgrade consisted of bringing 8 existing PBO stations within the Yellowstone volcanic region to near real-time communications. This work will be completed on time and in collaboration with the National Park Service. The upgrade promises to provide much faster latency for invaluable data being recorded for one of the most geodetically critical regions of the current PBO network. Another significant ongoing project in the East Region has been supporting the community that continues to use PBO data. In particular, support of Kristine Larson (Univ of CO) both in installing webcams at PBO sites for monitoring snow depth as well as supporting vegetative surveys at current PBO sites. Similarly, the East Region responded promptly to the community with requests for data quality issues that are station hardware related, including replacing GPS antennae and receivers. With regards to ongoing operations and maintenance projects, reasons for site visits in 2011 were dominated by two significant situations: battery replacement and CDMA modem swaps. 83 site visits were required as part of the Operations and Maintenance strategic battery plan of 5 year battery replacements. This proved to be a considerable challenge due to the scale and geography of the scheduled replacements- the sites were spread throughout the entire network, east to west and north to south. 20 station visits were required due to a Verizon upgrade of the older Alltel network purchased by Verizon. These stations are predominantly in the Rocky Mountain region, but often times had limited access to due weather. Overall, despite record snowfalls throughout the west, state of health

  14. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.

    Science.gov (United States)

    Gonzalez-Hurtado, Elsie; Lee, Jieun; Choi, Joseph; Wolfgang, Michael J

    2018-01-01

    To determine the role of fatty acid oxidation on the cellular, molecular, and physiologic response of brown adipose tissue to disparate paradigms of chronic thermogenic stimulation. Mice with an adipose-specific loss of Carnitine Palmitoyltransferase 2 (Cpt2 A-/- ), that lack mitochondrial long chain fatty acid β-oxidation, were subjected to environmental and pharmacologic interventions known to promote thermogenic programming in adipose tissue. Chronic administration of β3-adrenergic (CL-316243) or thyroid hormone (GC-1) agonists induced a loss of BAT morphology and UCP1 expression in Cpt2 A-/- mice. Fatty acid oxidation was also required for the browning of white adipose tissue (WAT) and the induction of UCP1 in WAT. In contrast, chronic cold (15 °C) stimulation induced UCP1 and thermogenic programming in both control and Cpt2 A-/- adipose tissue albeit to a lesser extent in Cpt2 A-/- mice. However, thermoneutral housing also induced the loss of UCP1 and BAT morphology in Cpt2 A-/- mice. Therefore, adipose fatty acid oxidation is required for both the acute agonist-induced activation of BAT and the maintenance of quiescent BAT. Consistent with this data, Cpt2 A-/- BAT exhibited increased macrophage infiltration, inflammation and fibrosis irrespective of BAT activation. Finally, obese Cpt2 A-/- mice housed at thermoneutrality exhibited a loss of interscapular BAT and were refractory to β3-adrenergic-induced energy expenditure and weight loss. Mitochondrial long chain fatty acid β-oxidation is critical for the maintenance of the brown adipocyte phenotype both during times of activation and quiescence. Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.

  15. Deuteron and neutron induced activation in the Eveda accelerator materials: implications for the accelerator maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, M.; Sanz, J.; Garcia, N.; Cabellos, O. [Madrid Univ. Politecnica, C/ Jose Gutierrez Abascal, lnstituto de Fusion Nuclear (Spain); Sauvan, R. [Universidad Nacional de Educacion a Distancia (UNED), Madrid (Spain); Moreno, C.; Sedano, L.A. [CIEMAT-Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Association Euratom-CIEMAT, Madrid (Spain)

    2007-07-01

    Full text of publication follows: The IFMIF (International Fusion Materials Irradiation Facility) is an accelerator-based DLi neutron source designed to test fusion reactor candidate materials for high fluence neutrons. Before deciding IFMIF construction, an engineering design and associated experimental data acquisition, defined as EVEDA, has been proposed. Along the EVEDA accelerator, deuteron beam losses collide with the accelerator materials, producing activation and consequent radiations responsible of dose. Calculation of the dose rates in the EVEDA accelerator room is necessary in order to analyze the feasibility for manual maintenance. Dose rates due to the activation produced by the deuteron beam losses interaction with the accelerator materials, will be calculated with the ACAB activation code, using EAF2007 library for deuteron activation cross-sections. Also, dose rates from the activation induced by the neutron source produced by the interaction of deuteron beam losses with the accelerator materials and the deuterium implanted in the structural lattice, will be calculated with the SRIM2006, TMAP7, DROSG2000/NEUYIE, MCNPX and ACAB codes. All calculations will be done for the EVEDA accelerator with the room temperature DTL structure, which is based on copper cavities for the DTL. Some calculations will be done for the superconducting DTL structure, based on niobium cavities for the DTL working at cryogenic temperature. Final analysis will show the dominant mechanisms and major radionuclides contributing to the surface dose rates. (authors)

  16. The impact of self-efficacy on physical activity maintenance in patients with hip osteoarthritis - a mixed methods study.

    Science.gov (United States)

    Hammer, Nanna Maria; Bieler, Theresa; Beyer, Nina; Midtgaard, Julie

    2016-08-01

    Understanding motivational factors related to physical activity (PA) maintenance is essential in promoting long-term exercise benefits. This study explored the impact of self-efficacy (SE) on post-intervention PA maintenance in patients with hip osteoarthritis. An SE-theory based mixed-methods sub-study of a trial investigating the effects of 4 months supervised exercise in patients with hip osteoarthritis. Questionnaire data (n = 52; baseline and 12 months) on PA and SE (Arthritis Self-Efficacy Scale, ASES, score-range 10-100) were analysed (Mann-Whitney test) for differences in characteristics of maintainers and non-maintainers. Semi-structured individual interviews (n = 15; at 12-months follow-up) were analysed using directed content analysis. Compared to non-maintainers (n = 9; 17%) maintainers (n = 31; 60%) had improved (p self-efficacy for physical activity contributes to the understanding of post-intervention physical activity maintenance in patients with hip osteoarthritis. Practitioners may benefit from incorporating the self-efficacy theory in the planning and execution of exercise interventions to promote post-intervention physical activity maintenance and long term health benefits. Post-intervention physical activity maintenance may be increased by focussing on the patients' exercise self-efficacy through verbal persuasion and support, disease-specific information and information on normal physiological responses to exercise combined with an individualised training progression to support experiences of success and achievement of desired outcomes.

  17. Hybrid Particle Swarm Optimization for Hybrid Flowshop Scheduling Problem with Maintenance Activities

    Science.gov (United States)

    Li, Jun-qing; Pan, Quan-ke; Mao, Kun

    2014-01-01

    A hybrid algorithm which combines particle swarm optimization (PSO) and iterated local search (ILS) is proposed for solving the hybrid flowshop scheduling (HFS) problem with preventive maintenance (PM) activities. In the proposed algorithm, different crossover operators and mutation operators are investigated. In addition, an efficient multiple insert mutation operator is developed for enhancing the searching ability of the algorithm. Furthermore, an ILS-based local search procedure is embedded in the algorithm to improve the exploitation ability of the proposed algorithm. The detailed experimental parameter for the canonical PSO is tuning. The proposed algorithm is tested on the variation of 77 Carlier and Néron's benchmark problems. Detailed comparisons with the present efficient algorithms, including hGA, ILS, PSO, and IG, verify the efficiency and effectiveness of the proposed algorithm. PMID:24883414

  18. Hybrid Particle Swarm Optimization for Hybrid Flowshop Scheduling Problem with Maintenance Activities

    Directory of Open Access Journals (Sweden)

    Jun-qing Li

    2014-01-01

    Full Text Available A hybrid algorithm which combines particle swarm optimization (PSO and iterated local search (ILS is proposed for solving the hybrid flowshop scheduling (HFS problem with preventive maintenance (PM activities. In the proposed algorithm, different crossover operators and mutation operators are investigated. In addition, an efficient multiple insert mutation operator is developed for enhancing the searching ability of the algorithm. Furthermore, an ILS-based local search procedure is embedded in the algorithm to improve the exploitation ability of the proposed algorithm. The detailed experimental parameter for the canonical PSO is tuning. The proposed algorithm is tested on the variation of 77 Carlier and Néron’s benchmark problems. Detailed comparisons with the present efficient algorithms, including hGA, ILS, PSO, and IG, verify the efficiency and effectiveness of the proposed algorithm.

  19. Hybrid particle swarm optimization for hybrid flowshop scheduling problem with maintenance activities.

    Science.gov (United States)

    Li, Jun-qing; Pan, Quan-ke; Mao, Kun

    2014-01-01

    A hybrid algorithm which combines particle swarm optimization (PSO) and iterated local search (ILS) is proposed for solving the hybrid flowshop scheduling (HFS) problem with preventive maintenance (PM) activities. In the proposed algorithm, different crossover operators and mutation operators are investigated. In addition, an efficient multiple insert mutation operator is developed for enhancing the searching ability of the algorithm. Furthermore, an ILS-based local search procedure is embedded in the algorithm to improve the exploitation ability of the proposed algorithm. The detailed experimental parameter for the canonical PSO is tuning. The proposed algorithm is tested on the variation of 77 Carlier and Néron's benchmark problems. Detailed comparisons with the present efficient algorithms, including hGA, ILS, PSO, and IG, verify the efficiency and effectiveness of the proposed algorithm.

  20. Cryogenics maintenance strategy

    Science.gov (United States)

    Cruzat, Fabiola

    2012-09-01

    ALMA is an interferometer composed of 66 independent systems, with specific maintenance requirements for each subsystem. To optimize the observation time and reduce downtime maintenance, requirements are very demanding. One subsystem with high maintenance efforts is cryogenics and vacuum. To organize the maintenance, the Cryogenic and Vacuum department is using and implementing different tools. These are monitoring and problem reporting systems and CMMS. This leads to different maintenance approaches: Preventive Maintenance, Corrective Maintenance and Condition Based Maintenance. In order to coordinate activities with other departments the preventive maintenance schedule is kept as flexible as systems allow. To cope with unavoidable failures, the team has to be prepared to work under any condition with the spares on time. Computerized maintenance management system (CMMS) will help to manage inventory control for reliable spare part handling, the correct record of work orders and traceability of maintenance activities. For an optimized approach the department is currently evaluating where preventive or condition based maintenance applies to comply with the individual system demand. Considering the change from maintenance contracts to in-house maintenance will help to minimize costs and increase availability of parts. Due to increased number of system and tasks the cryo team needs to grow. Training of all staff members is mandatory, in depth knowledge must be built up by doing complex maintenance activities in the Cryo group, use of advanced computerized metrology systems.

  1. Dosimetry results for AECL personnel involved in maintenance activities at off-shore CANDU stations

    International Nuclear Information System (INIS)

    Khaloo, R.

    1997-01-01

    Atomic Energy of Canada Limited (AECL) is intermittently involved in maintenance work on domestic and off-shore CANDU nuclear power plants. Maintenance activities, such as fuel-channel replacement (FCR), small-scale spacer location and relocation (SLARETTE) and primary-side steam-generator tube cleaning, require work in high-radiation fields. This may lead to appreciable radiation doses. AECL staff experience has been that these radiation doses accrue mostly from external gamma fields, with a minor internal dose component from the uptake of tritiated waste vapour. There are no significant uptakes of other radionuclides. AECL practice for SLARETTE and FCR work at off-shore CANDU stations has been to equip AECL personnel with 1 set of thermoluminescent dosimeters (TLDs) and 1 direct-reading personal alarming dosimeter (PAD). These TLDs are read at the Chalk River Laboratories of AECL. In addition, off-shore site radiation protection personnel issue AECL personnel with a TLD. This TLD is subsequently read at the off-shore site. Consequently, there are often three independent measurements of dose from external fields for AECL personnel. Internal dose assessments rely on off-shore radiation protection personnel. All off-shore CANDU stations use urine bioassay methods for tritiated water uptakes. Most off-shore CANDU sites also have lung or whole-body gamma spectrometry capabilities or both, which, if necessary, can be used to assess doses from uptakes of gamma-emitting airborne contaminants (e.g., from 60 Co, 95 Zr, 95 Nb, etc.). This paper discusses some internal and external dosimetry data for AECL personnel involved in recent FCR and SLARETTE work at off-shore CANDU stations. The data show that the whole-body dose contribution from uptake of tritiated heavy water is small. The data also show that three independent external dosimetry systems give dose results that are in relatively close agreement. Such information is invaluable in promoting confidence in the various

  2. Visual short-term memory: activity supporting encoding and maintenance in retinotopic visual cortex.

    Science.gov (United States)

    Sneve, Markus H; Alnæs, Dag; Endestad, Tor; Greenlee, Mark W; Magnussen, Svein

    2012-10-15

    Recent studies have demonstrated that retinotopic cortex maintains information about visual stimuli during retention intervals. However, the process by which transient stimulus-evoked sensory responses are transformed into enduring memory representations is unknown. Here, using fMRI and short-term visual memory tasks optimized for univariate and multivariate analysis approaches, we report differential involvement of human retinotopic areas during memory encoding of the low-level visual feature orientation. All visual areas show weaker responses when memory encoding processes are interrupted, possibly due to effects in orientation-sensitive primary visual cortex (V1) propagating across extrastriate areas. Furthermore, intermediate areas in both dorsal (V3a/b) and ventral (LO1/2) streams are significantly more active during memory encoding compared with non-memory (active and passive) processing of the same stimulus material. These effects in intermediate visual cortex are also observed during memory encoding of a different stimulus feature (spatial frequency), suggesting that these areas are involved in encoding processes on a higher level of representation. Using pattern-classification techniques to probe the representational content in visual cortex during delay periods, we further demonstrate that simply initiating memory encoding is not sufficient to produce long-lasting memory traces. Rather, active maintenance appears to underlie the observed memory-specific patterns of information in retinotopic cortex. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Effects of functional physical activity on the maintenance of motor function in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Laís Fajersztajn

    Full Text Available Abstract It is widely known that older adults, even frail individuals, can improve their physical function using appropriately targeted exercise. Nevertheless, older adults with Alzheimer's disease (AD have been excluded from the majority of studies on exercise. The functional-task physical activity program is based on activities of daily living, and may be suited for elderly people with AD because it focuses on the maintenance and stimulation of preserved abilities. In addition, session costs are substantially reduced by adopting a group approach. Furthermore, the group approach may improve the social interaction of the demented patient. Objectives: To determine whether a functional-task physical activity program in groups can maintain motor function in elderly with AD. Methods: 10 elderly diagnosed with mild or moderate AD were assigned into one of two groups: subjects with and without intervention. The intervention consisted of a 12-week function-task physical activity program in groups. Measurements: activities of daily living (Katz and Lawton & Brody questionnaires, mobility (Timed Up and Go Test, Timed Up and Go manual Test and Timed Up and Go Cognitive Test, cognition (Mini-Mental State Examination, behavioral disturbances (Neuropsychiatric Inventory I-brief and functional balance (Berg Balance Scale. Results: A statistically significant difference between the two groups was found regarding the functional balance mean change measured by Berg scale score (p=0.046. A significant improvement of 1.60 points (95%CI[0.22;2.98] was observed in the intervention group on this scale, while the non-intervention group showed -0.40 points (95%CI[-1.78;0.98], no change. Conclusions: It is possible to treat mild and moderate Alzheimer's patients using a group approach. The functional task physical activity program was efficient in functional balance improvement and also appeared to prevent mobility decline.

  4. Leisure-time activity is an important determinant of long-term weight maintenance after weight loss in the Sibutramine Trial on Obesity Reduction and Maintenance (STORM trial)

    DEFF Research Database (Denmark)

    van Baak, Marleen A; van Mil, Edgar; Astrup, Arne V

    2003-01-01

    The success rate of long-term maintenance of weight loss in obese patients is usually low. To improve the success rate, determinants of long-term weight maintenance must be identified.......The success rate of long-term maintenance of weight loss in obese patients is usually low. To improve the success rate, determinants of long-term weight maintenance must be identified....

  5. Deep brain stimulation of the subthalamic nucleus alters frontal activity during spatial working memory maintenance of patients with Parkinson's disease.

    Science.gov (United States)

    Mayer, Jutta S; Neimat, Joseph; Folley, Bradley S; Bourne, Sarah K; Konrad, Peter E; Charles, David; Park, Sohee

    2016-08-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). The STN may represent an important relay station not only in the motor but also the associative cortico-striato-thalamocortical pathway. Therefore, STN stimulation may alter cognitive functions, such as working memory (WM). We examined cortical effects of STN-DBS on WM in early PD patients using functional near-infrared spectroscopy. The effects of dopaminergic medication on WM were also examined. Lateral frontal activity during WM maintenance was greater when patients were taking dopaminergic medication. STN-DBS led to a trend-level worsening of WM performance, accompanied by increased lateral frontal activity during WM maintenance. These findings suggest that STN-DBS in PD might lead to functional modifications of the basal ganglia-thalamocortical pathway during WM maintenance.

  6. Brain Activation Patterns Associated with the Effects of Emotional Distracters during Working Memory Maintenance in Patients with Generalized Anxiety Disorder.

    Science.gov (United States)

    Park, Jong-Il; Kim, Gwang-Won; Jeong, Gwang-Woo; Chung, Gyung Ho; Yang, Jong-Chul

    2016-01-01

    Few studies have assessed the neural mechanisms of the effects of emotion on cognition in generalized anxiety disorder (GAD) patients. In this functional MRI (fMRI), we investigated the effects of emotional interference on working memory (WM) maintenance in GAD patients. Fifteen patients with GAD participated in this study. Event-related fMRI data were obtained while the participants performed a WM task (face recognition) with neutral and anxiety-provoking distracters. The GAD patients showed impaired performance in WM task during emotional distracters and showed greater activation on brain regions such as DLPFC, VLPFC, amygdala, hippocampus which are responsible for the active maintenance of goal relevant information in WM and emotional processing. Although our results are not conclusive, our finding cautiously suggests the cognitive-affective interaction in GAD patients which shown interfering effect of emotional distracters on WM maintenance.

  7. Augmented reality supported work instructions for onsite facility maintenance

    OpenAIRE

    Neges, Matthias; Koch, Christian

    2016-01-01

    During the operation and maintenance phase of buildings operators need to perform on site maintenance activities to prevent functional failures of technical equipment. As this phase is the longest and most expensive one respective improvements can significantly reduce the overall lifecycle budget. Based on their previous work, in this paper the authors present an Augmented Reality (AR) based concept and implementation to support mobile and onsite maintenance activities by (1) preparing and ge...

  8. RA reactor operation and maintenance in 1992, Part 1

    International Nuclear Information System (INIS)

    Sotic, O.; Cupac, S.; Sulem, B.; Zivotic, Z.; Majstorovic, D.; Tanaskovic, M.

    1992-01-01

    During 1992 Ra reactor was not in operation. All the activities were fulfilled according to the previously adopted plan. Basic activities were concerned with revitalisation of the RA reactor and maintenance of reactor components. All the reactor personnel was busy with reconstruction and renewal of the existing reactor systems and building of the new systems, maintenance of the reactor devices. Part of the staff was trained for relevant tasks and maintenance of reactor systems [sr

  9. Status of reliability in determining SDDR for manual maintenance activities in ITER: Quality assessment of relevant activation cross sections involved

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, R., E-mail: rgarciam@ind.uned.es [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain); Garcia, M. [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain); Pampin, R. [F4E, Torres Diagonal Litoral B3, Barcelona (Spain); Sanz, J. [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain)

    2016-11-15

    Highlights: • Feasibility of manual maintenance activities in ITER port cell and port interspace. • Activation of relevant materials and components placed in the current ITER model. • Dominant radionuclides and pathways for shutdown dose rate in ITER. • Quality analysis of typically used EAF and TENDL activation libraries is performed. • EAF performance found as trustworthy with slight recommended improvements. - Abstract: This paper assesses the quality of the EAF-2007 and 2010 activation cross sections for relevant reactions in the determination of the Shutdown Dose Rate (SDDR) in the Port Cell (PC) and Port Interspace (PI) areas of ITER. For each of relevant ITER materials, dominant radionuclides responsible of SDDR and their production pathways are listed. This information comes from a review of the recent reports/papers about SDDR in ITER and own calculations. A total of 26 relevant pathways are found. The quality of these cross sections pathways is assessed following EAF validation procedure, and for those found as not validated last TENDL library versions have been investigated in order to check possible improvements when compared to EAF. The use of EAF libraries is found as trustworthy and it is recommended for the prediction of SDDR in the ITER PC and PI. However, 3 cross section reactions are considered for further improvement: Co59(n,2n)Co58, Cu63(n,g)Cu64 and Cr50(n,g)Cr51.

  10. Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

    DEFF Research Database (Denmark)

    Campos, Lia S; Leone, Dino P; Relvas, Joao B

    2004-01-01

    , signalling is required for neural stem cell maintenance, as assessed by neurosphere formation, and inhibition or genetic ablation of beta1 integrin using cre/lox technology reduces the level of MAPK activity. We conclude that integrins are therefore an important part of the signalling mechanisms that control...

  11. Supporting activity engagement by family carers at home: maintenance of agency and personhood in dementia.

    Science.gov (United States)

    Chung, Pat Yin Fan; Ellis-Hill, Caroline; Coleman, Peter

    2017-12-01

    An explorative paper to describe how family carers, through the caregiving journey, reaffirm and promote the agency of people with dementia. Agency is an important concept in dementia care and is crucial to the promotion of wellbeing and the delivery of person-centred care. This article is based on one of the key findings of a study that explored family carers' experiences of engaging their relatives in daily activities in domestic settings. Following research governance and ethical approval, 30 in-depth interviews (initial and follow-up) were carried out with 15 resident-carers of people with dementia who were recruited via local community mental health teams. Then five focus groups were conducted with 21 participants accessed through carers support groups. Interviews and focus groups were transcribed, coded and analysed using a grounded theory method. Findings showed the process in which family carers encouraged and sustained a sense of autonomy and control (agency) in their relative's daily activities. Key strategies used by carers included: being non-judgemental; facilitating a sense of worth; taking calculated risks; maintaining the continuity of their relative's identity; enhancing a sense of connection with their relative's role and identity using enjoyable activities; preventing inactivity and attending to the bodily source of the agency. Lack of support for carers could ultimately pose a risk to the maintenance of the agency of people with dementia. This study provides a deeper insight into the process used by home carers to support the agency of people with dementia. This is essential if practitioners are to identify and develop more realistic intervention strategies and to work in effective partnership with family carers. The implications for the creation of dementia-friendly communities are discussed.

  12. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

    Directory of Open Access Journals (Sweden)

    Aisling O'Connor

    2016-01-01

    Full Text Available During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also involved in establishing the checkpoint and maintaining SAC signalling. However, mechanistically, the role of PLK1 in the SAC is not fully understood, with several recent reports indicating that it can cooperate with either one of the major checkpoint kinases, Aurora B or MPS1. In this study, we assess the role of PLK1 in SAC maintenance. We find that in nocodazole-arrested U2OS cells, PLK1 activity is continuously required for maintaining Aurora B protein localisation and activity at kinetochores. Consistent with published data we find that upon PLK1 inhibition, phosphoThr3-H3, a marker of Haspin activity, is reduced. Intriguingly, Aurora B inhibition causes PLK1 to relocalise from kinetochores into fewer and much larger foci, possibly due to incomplete recruitment of outer kinetochore proteins. Importantly, PLK1 inhibition, together with partial inhibition of Aurora B, allows efficient SAC override to occur. This phenotype is more pronounced than the phenotype observed by combining the same PLK1 inhibitors with partial MPS1 inhibition. We also find that PLK1 inhibition does not obviously cooperate with Haspin inhibition to promote SAC override. These results indicate that PLK1 is directly involved in maintaining efficient SAC signalling, possibly by cooperating in a positive feedback loop with Aurora B, and that partially redundant mechanisms exist which reinforce the SAC.

  13. Recent progress in the field of automated welding applied to maintenance activities

    International Nuclear Information System (INIS)

    Cullafroz, M.

    2004-01-01

    Automated and robot welding has 5 advantages compared to manual welding: -) under some conditions the automated circular welding does not require requalification testing as manual welding does, -) welding heads in robots have a reduced size compared to manual gears so they can enter and treat complex piping, -) by using an adequate viewing system the operator can be more than 10 meters away from the welding site which means that the radiation doses he receives is cut by a factor 1.5 to 2, -) whatever the configuration is, the deposition rate in automated welding stays high, the quality standard is steady and the risk of repairing is low, -) a gain in productivity if adequate equipment is used. In general, automated welding requires a TIG welding process and is applied in maintenance activities to: -) the main primary system and other circuits in stainless austenitic steels, -) the main secondary system and other circuits in low-percentage carbon steels, and -) the closure of spent fuel canisters. An application to the repairing of BWR's pipes is shown. (A.C.)

  14. MODELING A COMPUTER APPLICATION FOR MANAGEMENT OF MAINTENANCE ACTIVITIES OF UNPAVED ROADS

    Directory of Open Access Journals (Sweden)

    Ludmília de Souza Dias

    2015-08-01

    Full Text Available ABSTRACTThis study presents a contribution to the modeling of a computer application employing a method of serviceability performance for unpaved roads, aiming the management of maintenance/restoration activities of the primary surface layer. The proposed methodology consisted of field inspections during dry (April to September and rainy (October to March periods, during which objective evaluations were performed to survey of defects and their densities and degrees of severity. To aid the functional classification of analyzed road sections and the determination of the defect with major influence on the serviceability of these roads, the method of serviceability performance proposed by Silva (2009was implemented in the Visual Basic for Applications (VBA language in Microsoft Excel software. With the use of the computer application proposed it was possible to identify among the defects analyzed in field, through the index of serviceability of the sampling unit per defect type (ISUdef, which one had the greatest influence on determining the relative serviceability index per road section (IST. The results allow us to conclude that the computer application Road achieved satisfactory results, since the objective evaluation criteria applied to road sections denotes consistency regarding their serviceability.

  15. Manpower development for safe operation of nuclear power plant. China. Advice on maintenance planning. Activity: 3.1.2-Task-06. Technical report

    International Nuclear Information System (INIS)

    Chihara, Y.; Imai, K.

    1996-01-01

    Regarding the matter of quality assurance related to maintenance activities, we provided appropriate advice on the details of maintenance technologies and on quality control for the nuclear power plant. The advice was provided based on our experience in Japan, with explanations made from specialists' points of view in the form of a lecture. This also included an exchange of questions and answers regarding our experiences with quality control and maintenance activities in Japan

  16. Prediction of attendance at fitness center: a comparison between the theory of planned behavior, the social cognitive theory, and the physical activity maintenance theory

    OpenAIRE

    Jekauc, Darko; Völkle, Manuel; Wagner, Matthias O.; Mess, Filip; Reiner, Miriam; Renner, Britta

    2015-01-01

    In the processes of physical activity (PA) maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT) was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB) and Social Cognitive Theory (SCT). Participation rate in a fitness center was observed...

  17. Scheduling a maintenance activity under skills constraints to minimize total weighted tardiness and late tasks

    Directory of Open Access Journals (Sweden)

    Djalal Hedjazi

    2015-04-01

    Full Text Available Skill management is a key factor in improving effectiveness of industrial companies, notably their maintenance services. The problem considered in this paper concerns scheduling of maintenance tasks under resource (maintenance teams constraints. This problem is generally known as unrelated parallel machine scheduling. We consider the problem with a both objectives of minimizing total weighted tardiness (TWT and number of tardiness tasks. Our interest is focused particularly on solving this problem under skill constraints, which each resource has a skill level. So, we propose a new efficient heuristic to obtain an approximate solution for this NP-hard problem and demonstrate his effectiveness through computational experiments. This heuristic is designed for implementation in a static maintenance scheduling problem (with unequal release dates, processing times and resource skills, while minimizing objective functions aforementioned.

  18. Hand-Held and Portable Devices for Oil Assessment: Commercial Technologies for Maintenance Activities

    National Research Council Canada - National Science Library

    Urbansky, Edward T

    2006-01-01

    In an effort to reduce costs and bring about real-time oil assessment in the field while reducing maintenance costs, the Department of Defense seeks to further develop existing commercial technologies...

  19. Development of maintenance equipment for nuclear material fabrication equipment in a highly active hot cell

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. J.; Yang, M. S.; Kim, K. H. and others

    2000-09-01

    This report presents the development of a maintenance system for a highly contaminated nuclear material handling equipment at a hot-cell. This maintenance system has mainly three subsystems - a gamma-radiation measurement module for detecting a gamma-radiation level and identifying its distribution in-situ, a dry-type decontamination device for cleaning up contaminated particles, and a maintenance chamber for isolating contaminated equipment. The mechanical design considerations, controller, capabilities and remote operation and manipulation of the maintenance system are described. Such subsystems developed were installed and tested in the IMEF (Irradiated Material Examination Facility) M6 hot-cell after mock-up tests and performed their specific tasks successfully.

  20. Development of maintenance equipment for nuclear material fabrication equipment in a highly active hot cell

    International Nuclear Information System (INIS)

    Park, J. J.; Yang, M. S.; Kim, K. H. and others

    2000-09-01

    This report presents the development of a maintenance system for a highly contaminated nuclear material handling equipment at a hot-cell. This maintenance system has mainly three subsystems - a gamma-radiation measurement module for detecting a gamma-radiation level and identifying its distribution in-situ, a dry-type decontamination device for cleaning up contaminated particles, and a maintenance chamber for isolating contaminated equipment. The mechanical design considerations, controller, capabilities and remote operation and manipulation of the maintenance system are described. Such subsystems developed were installed and tested in the IMEF (Irradiated Material Examination Facility) M6 hot-cell after mock-up tests and performed their specific tasks successfully

  1. N-of-1 study of weight loss maintenance assessing predictors of physical activity, adherence to weight loss plan and weight change.

    Science.gov (United States)

    Kwasnicka, Dominika; Dombrowski, Stephan U; White, Martin; Sniehotta, Falko F

    2017-06-01

    Behaviour change interventions are effective in supporting individuals to achieve clinically significant weight loss, but weight loss maintenance (WLM) is less often attained. This study examined predictive variables associated with WLM. N-of-1 study with daily ecological momentary assessment combined with objective measurement of weight and physical activity, collected with wireless devices (Fitbit™) for six months. Eight previously obese adults who had lost over 5% of their body weight in the past year took part. Data were analysed using time series methods. Predictor variables were based on five theoretical themes: maintenance motives, self-regulation, personal resources, habits, and environmental influences. Dependent variables were: objectively estimated step count and weight, and self-reported WLM plan adherence. For all participants, daily fluctuations in self-reported adherence to their WLM plan were significantly associated with most of the explanatory variables, including maintenance motivation and satisfaction with outcomes, self-regulation, habit, and stable environment. Personal resources were not a consistent predictor of plan adherence. This is the first study to assess theoretical predictions of WLM within individuals. WLM is a dynamic process including the interplay of motivation, self-regulation, habit, resources, and perceptions of environmental context. Individuals maintaining their weight have unique psychological profiles which could be accounted for in interventions.

  2. Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

    Directory of Open Access Journals (Sweden)

    Maya Ben-Yehuda Greenwald

    2016-01-01

    Full Text Available The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc. producing reactive oxygen species (ROS and physical damage (e.g., wounds, sunburns also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2 is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1–Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1–Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1–Nrf2 pathway using nanotechnology-based delivery systems.

  3. Demonstration and manifestation of self-determination and illness resistance--a qualitative study of long-term maintenance of physical activity in posttreatment cancer survivors

    DEFF Research Database (Denmark)

    Midtgaard, Julie; Røssell, Kasper; Christensen, Jesper Frank

    2012-01-01

    The aim of this study was to describe posttreatment cancer survivors' lived experience of long-term maintenance of physical activity (PA).......The aim of this study was to describe posttreatment cancer survivors' lived experience of long-term maintenance of physical activity (PA)....

  4. Maintenance treatment with gemcitabine have a promising activity on metastatic bladder cancer survival.

    Science.gov (United States)

    Kuş, Tülay; Aktaş, Gökmen

    2017-09-01

    To investigate the effects of gemcitabine maintenance treatment on survival in patients with metastatic bladder cancer. Gemcitabine maintenance monotherapy was administered following the standard platinum-gemcitabine therapy in patients with metastatic bladder cancer. Patients who had responded to standard treatment received maintenance gemcitabine therapy as 1000 mg/m 2 on days 1 and 8 every three weeks until progression or development of unacceptable toxicity. The following clinical factors were noted: performance status, age, sex, stage, site of metastasis, choice of cisplatin-gemcitabine or carboplatin-gemcitabine, response rates to the initial chemotherapy. Progression-free survival (PFS) and overall survival (OS) for standard treatment, and following gemcitabine monotreatment and for maintenance gemcitabine therapy were calculated using Kaplan-Meier method. A total of 88 patients with metastatic bladder cancer treated between February 2009 to October 2015 were evaluated retrospectively and 23 patients (26.1%) who had responded to six cycles of platinum-gemcitabine treatment were included in this study. Maintenance gamcitabine was administered for a median of 7 times (range 3-14 times). Grade 3 hematotoxicity according to the criteria of the Common Terminology Criteria of Adverse Events was observed in 7 (30.4%) patients. Median PFS of patients was 46 (range: 30-82) weeks for platinum-based treatment plus maintenance gemcitabine therapy. A higher median PFS was obtained in patients who were maintenance therapy in metastatic bladder cancer patients who did not shown progression after the standard platinum-gemcitabine treatment contributes to survival and presents low toxicity profile, when compared to historical controls.

  5. Exploring end user adoption and maintenance of a telephone-based physical activity counseling service for individuals with physical disabilities using the Theoretical Domains Framework.

    Science.gov (United States)

    Tomasone, Jennifer R; Arbour-Nicitopoulos, Kelly P; Pila, Eva; Lamontagne, Marie-Eve; Cummings, Isabelle; Latimer-Cheung, Amy E; Routhier, François

    2017-06-01

    In Canada, two counseling services are offered to facilitate physical activity participation among persons with physical disabilities, yet both have encountered concerns related to the recruitment and retainment of clients. The purpose of this paper is to explore factors related to service adoption among nonusers, and the barriers and facilitators to maintaining service participation among adopters. Individuals who had never enrolled in the services (nonusers, n = 13) as well as current/previous service clients (adopters, n = 26) participated in interviews based on the Theoretical Domains Framework. Transcripts were subjected to deductive thematic analysis according to participant group. Fifteen themes relating to service adoption within 10 of the 12 theoretical domains were identified for nonusers, while 23 themes relating to maintenence of service participation were identified across all 12 theoretical domains for adopters. The findings provide strategies to improve recruitment, adoption, and retention of clients in counseling services and to enhance the experiences of targeted service users. Implications for Rehabiliation Peer support and education for equipment use should be built into physical activity programs to encourage participation among persons with physical disabilities. Programs that encourage physical activity among individuals with disabilities should be designed by practitioners to be responsive to a variety of needs, which are addressed in the program's advertisements and offerings. The Theoretical Domains Framework is a useful framework for providing valuable insight about clients' experiences of adoption and maintenance of a behavior change service, suggesting merit in other rehabilitation settings.

  6. NMR-based phytochemical analysis of Vitis vinifera cv Falanghina leaves. Characterization of a previously undescribed biflavonoid with antiproliferative activity.

    Science.gov (United States)

    Tartaglione, Luciana; Gambuti, Angelita; De Cicco, Paola; Ercolano, Giuseppe; Ianaro, Angela; Taglialatela-Scafati, Orazio; Moio, Luigi; Forino, Martino

    2018-03-01

    Vitis vinifera cv Falanghina is an ancient grape variety of Southern Italy. A thorough phytochemical analysis of the Falanghina leaves was conducted to investigate its specialised metabolite content. Along with already known molecules, such as caftaric acid, quercetin-3-O-β-d-glucopyranoside, quercetin-3-O-β-d-glucuronide, kaempferol-3-O-β-d-glucopyranoside and kaempferol-3-O-β-d-glucuronide, a previously undescribed biflavonoid was identified. For this last compound, a moderate bioactivity against metastatic melanoma cells proliferation was discovered. This datum can be of some interest to researchers studying human melanoma. The high content in antioxidant glycosylated flavonoids supports the exploitation of grape vine leaves as an inexpensive source of natural products for the food industry and for both pharmaceutical and nutraceutical companies. Additionally, this study offers important insights into the plant physiology, thus prompting possible technological researches of genetic selection based on the vine adaptation to specific pedo-climatic environments. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Present status and future of maintenance robots of nuclear power plants. Part 2. Toshiba Corporation's activity

    International Nuclear Information System (INIS)

    Naruse, Katsuhiko; Sato, Katsuhiko

    2005-01-01

    Underwater remotely operated vehicle for inspection, repair and preventive maintenance in a narrow space had been developed with advanced robot technologies. Maintenance robot for core internals worked under high radiation environment and size limit of applied parts and passage space. Visual inspection (VT) and ultrasonic testing (UT) of welds using core shroud vehicle had been realized. Swimming type vehicle for VT and crawler type vehicle for cleaning was also prepared. Position measuring system for VT with image processing based on position information of movable joint axis and micro replica equipment to obtain microstructure image of structure surface could be combined. Underwater remotely operated maintenance and repair system was applied to improve surface stresses around welds to compression with laser peening technology and also to remove cracks with electric discharge machining for prevention of crack propagation. (T. Tanaka)

  8. Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer

    DEFF Research Database (Denmark)

    Dizon, Don S; Damstrup, Lars; Finkler, Neil J

    2012-01-01

    BACKGROUND: Preclinical data show that belinostat (Bel) is synergistic with carboplatin and paclitaxel in ovarian cancer. To further evaluate the clinical activity of belinostat, carboplatin, and paclitaxel (BelCaP), a phase 1b/2 study was performed, with an exploratory phase 2 expansion planned...... end point was overall response rate (ORR), using a Simon 2 stage design. RESULTS: The median age was 60 years (range, 39-80 years), and patients had received a median of 3 prior regimens (range, 1-4). Fifty-four percent had received more than two prior platinum-based combinations, sixteen patients (46...

  9. Contextual care of the patient following weight-loss surgery: Relational views and maintenance activities of couples.

    Science.gov (United States)

    Aramburu Alegría, Christine; Larsen, Barbara

    2017-01-01

    Weight-loss surgery (WLS) is a popular means toward achieving weight loss. Numerous studies report on the psychological and physical benefits of the procedure. Patients who have supportive others often demonstrate improved outcomes as compared to those who may not have support. The present study examines relationship maintenance activities that may contribute to a couple's positive adjustment following WLS, along with relational views that may modify and evolve as patients continue to lose weight. Eleven heterosexual couples in which the female had WLS participated in in-depth, semistructured interviews. A deductive method of analysis was used to categorize relationship maintenance activities; an inductive method was used to examine relational views. Six types of relationship maintenance activities proved beneficial following WLS: (1) openness, (2) assurances, (3) food/meals as shared tasks, (4) joint activities, (5) antisocial, and (6) affection. In describing their relational views, participants spoke to the increasing independence, confidence, and self-focus of those who had had WLS. A persistent fat identity was also reported. The findings can provide advanced practice nurses and other clinicians additional insight into, and strategies to assist, couples who have experienced, or will experience, WLS within their relationship. ©2016 American Association of Nurse Practitioners.

  10. Recent progress in the field of automated welding applied to maintenance activities; Avancees recentes dans le domaine du soudage automatique et robotise applique a la maintenance des equipements

    Energy Technology Data Exchange (ETDEWEB)

    Cullafroz, M. [FRAMATOME ANP, 92 - Paris-La-Defence (France)

    2004-07-01

    Automated and robot welding has 5 advantages compared to manual welding: -) under some conditions the automated circular welding does not require requalification testing as manual welding does, -) welding heads in robots have a reduced size compared to manual gears so they can enter and treat complex piping, -) by using an adequate viewing system the operator can be more than 10 meters away from the welding site which means that the radiation doses he receives is cut by a factor 1.5 to 2, -) whatever the configuration is, the deposition rate in automated welding stays high, the quality standard is steady and the risk of repairing is low, -) a gain in productivity if adequate equipment is used. In general, automated welding requires a TIG welding process and is applied in maintenance activities to: -) the main primary system and other circuits in stainless austenitic steels, -) the main secondary system and other circuits in low-percentage carbon steels, and -) the closure of spent fuel canisters. An application to the repairing of BWR's pipes is shown. (A.C.)

  11. A Human Error Analysis Procedure for Identifying Potential Error Modes and Influencing Factors for Test and Maintenance Activities

    International Nuclear Information System (INIS)

    Kim, Jae Whan; Park, Jin Kyun

    2010-01-01

    Periodic or non-periodic test and maintenance (T and M) activities in large, complex systems such as nuclear power plants (NPPs) are essential for sustaining stable and safe operation of the systems. On the other hand, it also has been raised that human erroneous actions that might occur during T and M activities has the possibility of incurring unplanned reactor trips (RTs) or power derate, making safety-related systems unavailable, or making the reliability of components degraded. Contribution of human errors during normal and abnormal activities of NPPs to the unplanned RTs is known to be about 20% of the total events. This paper introduces a procedure for predictively analyzing human error potentials when maintenance personnel perform T and M tasks based on a work procedure or their work plan. This procedure helps plant maintenance team prepare for plausible human errors. The procedure to be introduced is focusing on the recurrent error forms (or modes) in execution-based errors such as wrong object, omission, too little, and wrong action

  12. Physical activity maintenance among Spanish-speaking Latinas in a randomized controlled trial of an Internet-based intervention.

    Science.gov (United States)

    Hartman, Sheri J; Dunsiger, Shira I; Bock, Beth C; Larsen, Britta A; Linke, Sarah; Pekmezi, Dori; Marquez, Becky; Gans, Kim M; Mendoza-Vasconez, Andrea S; Marcus, Bess H

    2017-06-01

    Spanish-speaking Latinas have some of the lowest rates of meeting physical activity guidelines in the U.S. and are at high risk for many related chronic diseases. The purpose of the current study was to examine the maintenance of a culturally and individually-tailored Internet-based physical activity intervention for Spanish-speaking Latinas. Inactive Latinas (N  =  205) were randomly assigned to a 6-month Tailored Physical Activity Internet Intervention or a Wellness Contact Control Internet Group, with a 6-month follow-up. Maintenance was measured by assessing group differences in minutes per week of self-reported and accelerometer measured moderate to vigorous physical activity (MVPA) at 12 months after baseline and changes in MVPA between the end of the active intervention (month 6) and the end of the study (month 12). Potential moderators of the intervention were also examined. Data were collected between 2011 and 2014, and were analyzed in 2015 at the University of California, San Diego. The Intervention Group engaged in significantly more minutes of MVPA per week than the Control Group at the end of the maintenance period for both self-reported (mean diff. = 30.68, SE = 11.27, p = .007) and accelerometer measured (mean diff. = 11.47, SE = 3.19, p = .01) MVPA. There were no significant between- or within-group changes in MVPA from month 6 to 12. Greater intervention effects were seen for those with lower BMI (BMI × intervention = -6.67, SE = 2.88, p = .02) and lower perceived places to walk to in their neighborhood (access × intervention = -43.25, SE = 19.07, p = .02), with a trend for less family support (social support × intervention = -3.49, SE = 2.05, p = .08). Acculturation, health literacy, and physical activity related psychosocial variables were not significant moderators of the intervention effect during the maintenance period. Findings from the current study support the efficacy of an Internet

  13. Improvements to executive function during exercise training predict maintenance of physical activity over the following year

    Directory of Open Access Journals (Sweden)

    John eBest

    2014-05-01

    Full Text Available Previous studies have shown that exercise training benefits cognitive, neural, and physical health markers in older adults. It is likely that these positive effects will diminish if participants return to sedentary lifestyles following training cessation. Theory posits that that the neurocognitive processes underlying self-regulation, namely executive function (EF, are important to maintaining positive health behaviors. Therefore, we examined whether better EF performance in older women would predict greater adherence to routine physical activity (PA over 1 year following a 12-month resistance exercise training randomized controlled trial. The study sample consisted of 125 community-dwelling women aged 65 to 75 years old. Our primary outcome measure was self-reported PA, as measured by the Physical Activity Scale for the Elderly (PASE, assessed on a monthly basis from month 13 to month 25. Executive function was assessed using the Stroop Test at baseline (month 0 and post-training (month 12. Latent growth curve analyses showed that, on average, PA decreased during the follow-up period but at a decelerating rate. Women who made greater improvements to EF during the training period showed better adherence to PA during the 1-year follow-up period (β = -.36, p .10. Overall, these findings suggest that improving EF plays an important role in whether older women maintain higher levels of PA following exercise training and that this association is only apparent after training when environmental support for PA is low.

  14. Annual report on surveillance and maintenance activities at Oak Ridge National Laboratory, Oak Ridge, Tennessee, fiscal year 1996

    International Nuclear Information System (INIS)

    1996-11-01

    In fiscal year (FY) 1995, the sites and facilities from both the Remedial Action (RA) and Decontamination and Decommissioning (D and D) programs were combined to form the Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Surveillance and Maintenance (S and M) Program. Surveillance and Maintenance activities were conducted throughout FY 1996 at the RA facilities. Overall, the RA S and M Program consists of approximately 650 acres that include 14 waste area groupings with approximately 200 sites. These sites include 46 major facilities, several leak and contaminated soil sites, 38 inactive tanks, approximately 50 environmental study areas and approximately 2,973 wells and boreholes. Site inspections were conducted at established frequencies on appropriate sites in the RA S and M Program in accordance with the established S and M FY 1996 Incentive Task Order (ITO)

  15. Activities for turbine maintenance: planning, implementation and evaluation of inspection results

    International Nuclear Information System (INIS)

    Azcue, J.; Sanchez, M. A.; Alvaro, M.

    2014-01-01

    The article will cover the most significant aspects of how Tecnatom carry out the turbine maintenance work, both from the point of view of the inspection itself as the pre-and post tasks associated. Thus, the issues that will be part of the article are the Manual Inspection Service (MISI) and the inspection database, ISI WEB. These tools are essential for planning field work and serve as a guide to run later turbine inspections in different plants. Following this introduction the inspection teams and the techniques used by Tecnatom will be described. finally, the article will contain a small mention about management studies of life and integrity analysis of the turbine that can be performed, as well as involvement in its safe operation that is derived from them. Ultimately, the intention is to provide a comprehensive approach to the issue in question, the turbine maintenance work, so that the reader can get an ideal of the whole process. (Author)

  16. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.

    1959-01-01

    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  17. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Science.gov (United States)

    2010-04-01

    ... Transportation Facility Maintenance Management System (TFMMS). 16. Performing pavement maintenance such as pot hole patching, crack sealing, chip sealing, surface rejuvenation, and thin overlays (less than 1 inch...

  18. Maintenance management systems

    International Nuclear Information System (INIS)

    Rohan, M. de

    1989-01-01

    This paper is concerned principally with Maintenance Management systems and their effective introduction into organisations. Maintenance improvement is basically a problem of managing the maintenance department in the broadest sense. Improvement does not only lie in the area of special techniques, systems or procedures; although they are valuable tools, but rather in a balanced attack, carefully guided by management. Over recent years, maintenance systems have received the major emphasis and in many instances the selection of the system has become a pre-occupation, whereas the importance of each maintenance function must be recognised and good management practices applied to all maintenance activities. The ingredients for success in the implementation of maintenance management systems are summarised as: having a management committee, clear objectives, project approach using project management techniques and an enthusiastic leader, user managed and data processing supported project, realistic budget and an understanding of the financial audit requirements. (author)

  19. Building relationships for better maintenance.

    Science.gov (United States)

    Lee, Hackman Hon Yin; Scott, David

    2009-02-01

    Effective management of building maintenance is a vital ingredient in ensuring a high quality built environment for any building's occupiers. However, maintenance is not high on the list of priorities for most organisations. Communication between top management personnel looking at maintenance issues from a strategic standpoint and maintenance staff considering them at an operational level is often not as good as it should be. When planning maintenance activities maintenance personnel often draw too heavily on their technical experience and expertise without taking sufficient account of wider organisational objectives or consulting effectively with top management. Senior managers also regularly complain about lack of managerial input from maintenance departments. Such barriers contribute to communication difficulties between top management at a strategic level and maintenance personnel at an operational level. Identifying where the key differences lie in senior managers' and maintenance personnel's viewpoints on maintenance strategy can prove invaluable in achieving some convergence of opinions and optimising the efficiency of the overall building maintenance process.

  20. Serotonin-dependent maintenance of spatial performance and electroencephalography activation after cholinergic blockade: effects of serotonergic receptor antagonists.

    Science.gov (United States)

    Dringenberg, H C; Zalan, R M

    1999-08-07

    The interaction between acetylcholine (ACh) and serotonin (5-hydroxytryptamine, 5-HT) in the control of behavior such as spatial navigation has received considerable attention over the last years. Previous research indicates that while a selective reduction in cholinergic transmission often produces only mild impairments in spatial and other behavioral tests, additional serotonergic blockade results in the appearance of severe behavioral deficits. Consequently, it has been argued that 5-HT plays a role in the maintenance of behavioral capacities in the face of reduced cholinergic transmission. Here, we examined the effects of 5-HT depletion and receptor blockade, alone and in combination with cholinergic-muscarinic antagonism, on spatial navigation of rats in the Morris water maze. Further, electroencephalographic (EEG) recordings were taken to test the hypothesis that a loss of neocortical activation is related to the behavioral deficits apparent after cholinergic-serotonergic blockade. The muscarinic antagonist, scopolamine (1 mg/kg) produced a moderate impairment in navigational performance. The 5-HT depletor, p-chlorophenylalanine (PCPA; 500 mg kg(-1) day(-1)x2) did not impair performance when given alone but strongly potentiated the scopolamine-induced deficit and completely blocked the acquisition of an escape response in the water maze. This effect was mimicked by the non-selective serotonin(1-2) receptor antagonist, methiothepin (0.3 mg/kg), but not by the selective serotonin(1A) antagonist, WAY 100635 (0.1-0.5 mg/kg) or the serotonin(2) antagonist, ketanserin (2-4 mg/kg). None of the 5-HT antagonists impaired performance when given alone. Electrocorticographic recordings in rats treated with scopolamine and serotonergic receptor antagonists showed that during behavioral immobility, scopolamine (1 mg/kg) increased spectral power in all frequency bands between 0.5 and 20 Hz without significantly affecting cortical activity during movement. None of the 5-HT

  1. Roadside maintenance

    Science.gov (United States)

    2010-01-01

    Roadside Maintenance is a unique element within the highway maintenance program because much of the work involves caring for and/or controlling vegetation. Roadside vegetation, if managed properly, can become more naturally self-sustaining over time ...

  2. Lean Maintenance Applied to Improve Maintenance Efficiency in Thermoelectric Power Plants

    Directory of Open Access Journals (Sweden)

    Orlando Duran

    2017-10-01

    Full Text Available Thermoelectric power plants consist of a set of critical equipment that require high levels of availability and reliability. Due to this, maintenance of these physical assets is gaining momentum in industry. Maintenance is considered as an activity that contributes to improving the availability, efficiency and productivity of each piece of equipment. Several techniques have been used to achieve greater efficiencies in maintenance, among which we can find the lean maintenance philosophy. Despite the wide diffusion of lean maintenance, there is no structured method that supports the prescription of lean tools applied to the maintenance function. This paper presents the experience gathered in two lean maintenance projects in thermoelectric power plants. The application of lean techniques was based on using a previously developed multicriterial decision making process that uses the Fuzzy Analytic Hierarchy Process (AHP methodology to carry out a diagnosis and prescription tasks. That methodology allowed the prescription of the appropriated lean techniques to resolve the main deficiencies in maintenance function. The results of applying such lean tools show that important results can be obtained, making the maintenance function in thermoelectric power plants more efficient and lean.

  3. A framework for the design of a voice-activated, intelligent, and hypermedia-based aircraft maintenance manual

    Science.gov (United States)

    Patankar, Manoj Shashikant

    Federal Aviation Regulations require Aviation Maintenance Technicians (AMTs) to refer to approved maintenance manuals when performing maintenance on airworthy aircraft. Because these manuals are paper-based, larger the size of the aircraft, more cumbersome are the manuals. Federal Aviation Administration (FAA) recognized the difficulties associated with the use of large manuals and conducted studies on the use of electronic media as an alternative to the traditional paper format. However, these techniques do not employ any artificial intelligence technologies and the user interface is limited to either a keyboard or a stylus pen. The primary emphasis of this research was to design a generic framework that would allow future development of voice-activated, intelligent, and hypermedia-based aircraft maintenance manuals. A prototype (VIHAMS-Voice-activated, Intelligent, and Hypermedia-based Aircraft Maintenance System) was developed, as a secondary emphasis, using the design and development techniques that evolved from this research. An evolutionary software design approach was used to design the proposed framework and the structured rapid prototyping technique was used to produce the VIHAMS prototype. VoiceAssist by Creative Labs was used to provide the voice interface so that the users (AMTs) could keep their hands free to work on the aircraft while maintaining complete control over the computer through discrete voice commands. KnowledgePro for Windows sp{TM}, an expert system shell, provided "intelligence" to the prototype. As a result of this intelligence, the system provided expert guidance to the user. The core information contained in conventional manuals was available in a hypermedia format. The prototype's operating hardware included a notebook computer with a fully functional audio system. An external microphone and the built-in speaker served as the input and output devices (along with the color monitor), respectively. Federal Aviation Administration

  4. Annual summary report on the surveillance and maintenance activities for the Oak Rige National Laboratory Environmental Restoration Program for fiscal year 1995

    International Nuclear Information System (INIS)

    1995-11-01

    This Annual Summary Report on the Surveillance and Maintenance Activities for the Oak Ridge National Laboratory Environmental Restoration Program for Fiscal Year 1995 was prepared to communicate the accomplishments of the Program during fiscal year 1995. This work was performed under work breakdown structure element 1.4.12.6.1.14.20 (activity data sheet 3314, ''Remedial Action Surveillance and Maintenance''). Publication of this document meets the Life Cycle Baseline milestone date of November 30, 1995. This document provides the accomplishments for both the Remedial Action and Decontamination and Decommissioning Surveillance and Maintenance programs

  5. Observations of the Behavior and Distribution of Fish in Relation to the Columbia River Navigation Channel and Channel Maintenance Activities

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Thomas J.; Ploskey, Gene R.; Johnson, R. L.; Mueller, Robert P.; Weiland, Mark A.; Johnson, P. N.

    2001-10-19

    This report is a compilation of 7 studies conducted for the U.S. Army Corps of Engineers between 1995 and 1998 which used hydroacoustic methods to study the behavior of migrating salmon in response to navigation channel maintenance activities in the lower Columbia River near river mile 45. Differences between daytime and nighttime behavior and fish densities were noted. Comparisons were made of fish distribution across the river (in the channel, channel margin or near shore) and fish depth upstream and downstream of dikes, dredges, and pile driving areas.

  6. A company-wide activity to grow safety culture in a maintenance department of nuclear power plant

    International Nuclear Information System (INIS)

    Fukui, Hirokazu; Sugiman, Toshio

    2008-01-01

    This study aims to conduct a field survey to collect specific instances of 'learning activity' that would help develop a safety culture in a maintenance department of nuclear power plant, with 'activity theory' as a theoretical base, and to derive a conceptual model that portrays these instances as part of comprehensive organizational activities. First, the field survey found instances where an accident that occurred a few years ago provided momentum; a company-wide activity is being implemented in order to fulfill the requests of field workers so that their requests for improvements are positively honored and budgets are allocated to measures designed to accommodate these requests. This paper calls this company-wide activity 'an activity to materialize the requests for improvements in the workplace' and considers it to be a typical instance of learning activity. Second, the field survey found that, in the workplace under discussion, a daily meeting was held in a unique way and a study session was conducted frequently and regularly. Last, we came up with a conceptual model for the entire aspect of organizational activities in which we could position the above instances as well as the results of our past field surveys. This model conceptualizes organizational activities from the two aspects of 'learning activity (primary learning activity)' and 'management activity) and characterizes an activity that would transform the existing organizational activities into ones that could not be even predicted as 'secondary learning activity'. 'An activity to materialize the requests for improvement in the workplace' was taken as falling under the category of secondary learning activity. (author)

  7. The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks.

    Directory of Open Access Journals (Sweden)

    Audrey Costes

    2010-12-01

    Full Text Available We have investigated in vivo the role of the carboxy-terminal domain of the Bacillus subtilis Single-Stranded DNA Binding protein (SSB(Cter as a recruitment platform at active chromosomal forks for many proteins of the genome maintenance machineries. We probed this SSB(Cter interactome using GFP fusions and by Tap-tag and biochemical analysis. It includes at least 12 proteins. The interactome was previously shown to include PriA, RecG, and RecQ and extended in this study by addition of DnaE, SbcC, RarA, RecJ, RecO, XseA, Ung, YpbB, and YrrC. Targeting of YpbB to active forks appears to depend on RecS, a RecQ paralogue, with which it forms a stable complex. Most of these SSB partners are conserved in bacteria, while others, such as the essential DNA polymerase DnaE, YrrC, and the YpbB/RecS complex, appear to be specific to B. subtilis. SSB(Cter deletion has a moderate impact on B. subtilis cell growth. However, it markedly affects the efficiency of repair of damaged genomic DNA and arrested replication forks. ssbΔCter mutant cells appear deficient in RecA loading on ssDNA, explaining their inefficiency in triggering the SOS response upon exposure to genotoxic agents. Together, our findings show that the bacterial SSB(Cter acts as a DNA maintenance hub at active chromosomal forks that secures their propagation along the genome.

  8. Maintenance methods

    International Nuclear Information System (INIS)

    Sanchis, H.; Aucher, P.

    1990-01-01

    The maintenance method applied at the Hague is summarized. The method was developed in order to solve problems relating to: the different specialist fields, the need for homogeneity in the maintenance work, the equipment diversity, the increase of the materials used at the Hague's new facilities. The aim of the method is to create a knowhow formalism, to facilitate maintenance, to ensure the running of the operations and to improve the estimation of the maintenance cost. One of the method's difficulties is the demonstration of the profitability of the maintenance operations [fr

  9. Decision support in maintenance activity by using modern techniques for equipment condition monitoring

    Directory of Open Access Journals (Sweden)

    Paunescu Ionel

    2017-01-01

    Full Text Available As the complexity of the equipment and embedded technologies grow, the decision to take action for keeping the normal operation condition is increasingly challenging. The development of methods and instruments meant to improve availability, reliability and maintainability of equipment involves research on the of the related subassemblies and components in various conditions of operation. To maximize technical system performance, to ensure the operational safety and to decrease functioning costs, the authors of this paper propose the implementation of some monitoring techniques, using technical indicators specific to the system (markers for maintenance and an innovative process based on the electricity footprint method for monitoring the operational behavior of the critical items in a kinematic chain. The analysis of the monitoring techniques presented in this paper leads to an effective act for keeping the normal operation condition of a technical system.

  10. Plant management and maintenance including graphical activation, business process manager and electronic signature

    Energy Technology Data Exchange (ETDEWEB)

    Hippmann, N. [RWE Systems Applications GmbH, Essen (Germany)

    2003-07-01

    The use of information technology in order to support the management of power plants is certainly not a utility's core business. In any case, the competition pressure caused by the liberalisation of the energy market and - until now - hardly considered possible by experts in the industry, is calling for technical solutions to compensate the savings that are generally considered to represent the major savings potential within the framework of increases in efficiency, i.e. the human resources. Not only the quantitative reduction of the management and maintenance staff, but even more the resulting loss of know-how of experienced unit heads, boiler and machine operators makes it necessary to have technological solutions perform such tasks. Even and especially in times of great technological progress and serious changes to the market situation, both new and approved solutions in the IT business are a chance to meet new requirements. (orig.)

  11. Analysis of maintenance strategies

    International Nuclear Information System (INIS)

    Laakso, K.; Simola, K.

    1998-01-01

    The main topics of the presentation include: (1) an analysis model and methods to evaluate maintenance action programs and the support decision to make changes in them and (2) to understand the maintenance strategies in a systems perspective as a basis for future developments. The subproject showed how systematic models for maintenance analysis and decision support, utilising computerised and statistical tool packages, can be taken into use for evaluation and optimisation of maintenance of active systems from the safety and economic point of view

  12. Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node.

    Directory of Open Access Journals (Sweden)

    Rebecca Anne Capel

    2015-02-01

    Full Text Available The sino-atrial node (SAN provides the electrical stimulus to initiate every heart beat. Cellular processes underlying this activity have been debated extensively, especially with regards to the role of intracellular calcium. We have used whole-cell application of 1,2-bis(o-aminophenoxyethane-N,N,N',N'-tetraacetic acid (BAPTA, a rapid calcium chelator, to guinea pig isolated SAN myocytes to assess the effect of rapid reduction of intracellular calcium on SAN cell electrical activity. High-dose (10 mM BAPTA induced rapid and complete cessation of rhythmic action potential (AP firing (time to cessation 5.5±1.7 s. Over a range of concentrations, BAPTA induced slowing of action potential firing and disruption of rhythmic activity, which was dose-dependent in its time of onset. Exposure to BAPTA was associated with stereotyped action potential changes similar to those previously reported in the presence of ryanodine, namely depolarisation of the most negative diastolic potential, prolongation of action potentials and a reduction in action potential amplitude. These experiments are consistent with the view that cytosolic calcium is essential to the maintenance of rhythmic pacemaker activity.

  13. FY 1994 annual summary report of the surveillance and maintenance activities for the Oak Ridge National Laboratory Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    The Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Surveillance and Maintenance (S and M) Program was initiated to manage former waste management and environmental research sites contaminated with radioactive materials and/or hazardous chemicals. The S and M Program is responsible for managing designated sites/facilities from the end of their operating lives until final disposition or site stabilization. To effectively manage and perform the various S and M Program responsibilities, five summary-level work breakdown structure (WBS) elements have been established: S and M Preliminary Investigations, Special Projects, Routine S and M, Inactive Groundwater Wells, and Project Management. Routine S and M activities were conducted as scheduled throughout fiscal years (FY) 1994 at applicable inactive waste management (WM) and other contaminated areas. Overall, the ER S and M Program maintains 47 facilities, performs vegetation maintenance on approximately 230 acres, maintains 54 inactive tanks, and provides overall site management on over 700 acres. In addition to the routine S and M activities, detailed site inspections were conducted at established frequencies on appropriate sites in the ER S and M Program. This document provides a summary of the FY 1994 ORNL ER S and M Program accomplishments.

  14. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

    Directory of Open Access Journals (Sweden)

    Daniel T. Utzschneider

    2018-03-01

    Full Text Available Summary: Immunity following an acutely resolved infection or the long-term equipoise of chronic viral infections often depends on the maintenance of antigen-specific CD8+ T cells, yet the ongoing transcriptional requirements of these cells remain unclear. We show that active and continuous programming by FOXO1 is required for the functional maintenance of a memory population. Upon Foxo1 deletion following resolution of an infection, memory cells rapidly lost their characteristic gene expression, gradually declined in number, and were impaired in self-renewal. This was extended to chronic infections, as a loss of FOXO1 during a persistent viral infection led to a rapid decline of the TCF7 (a.k.a. TCF1-expressing memory-like subset of CD8+ T cells. We further establish FOXO1 regulation as a characteristic of human memory CD8+ T cells. Overall, we show that the molecular and functional longevity of a memory T cell population is actively maintained by the transcription factor FOXO1. : Utzschneider et al. find that hallmarks of CD8+ T cell memory such as longevity, self-renewal, and the ability to cycle between quiescence and cell division depend on continued expression of FOXO1. Loss of FOXO1 during any of these stages leads to the interruption of T cell memory. Keywords: immune memory, homeostatic proliferation, self-renewal, quiescence, cell survival, T cells, FOXO, TCF1/TCF7, chronic infection, LCMV

  15. Endocardial focal activation originating from Purkinje fibers plays a role in the maintenance of long duration ventricular fibrillation.

    Science.gov (United States)

    Lin, Changjian; Jin, Qi; Zhang, Ning; Zhou, Jian; Pang, Yang; Xin, Yangxun; Liu, Shaohua; Wu, Qiong; Wu, Liqun

    2014-04-01

    To determine the role of repetitive endocardial focal activations and Purkinje fibers in the maintenance of long duration ventricular fibrillation (LDVF, VF>1 minute) in canine hearts in vivo. The study was conducted in electrophysiological laboratory of Shanghai Ruijin hospital from July 2010 to August 2012. A 64-electrode basket was introduced through a carotid artery into the left ventricle (LV) of 11 beagle dogs for global endocardial electrical mapping. In the Lugol's solution group (n=5), the subendocardium was ablated by washing with Lugol's solution. In the control group, (n=6) saline was used for ablation. Before and after saline or Lugol ablation, we determined QRS duration and QT/QTc interval in sinus rhythm (SR). We also measured the activation rates in the first 2 seconds of each minute during 7 minutes of VF for each group. If VF terminated spontaneously in less than 7 minutes, the VF segments used in activation rate analysis were reduced accordingly. At the beginning of VF there was no difference between the groups in the activation rate. However, after 1 minute of LDVF the Lugol's solution group had significantly slower activation rate than the control group. In the control group, all episodes of LDVF (6/6) were successfully sustained for 7 minutes, while in the Lugol's solution group 4/5 episodes of LDVF spontaneously terminated before 7 minutes (4.8±1.4 minutes) (P=0.015). In the control group, at 5.1±1.3 minutes of LDVF, a successive, highly organized focal LV endocardial activation pattern was observed. During this period, activations partly arose in PF and spread to the working ventricular myocardium. Mapping analysis showed that these events were consistent with repetitive endocardial focal activations. No evidence of similar focal activations was observed in the Lugol's solution group. Repetitive endocardial focal activations in the LV endocardium may be associated with activation of subendocardial PFs. This mechanism may play an important

  16. Recent activities within Nuclear Electric related to the qualification of digital systems and the extension of maintenance intervals

    International Nuclear Information System (INIS)

    Holt, G.P.

    1993-01-01

    Nuclear Electric is pursuing a program of modernization and enhancement of existing control and safety (C ampersand I) systems to improve power plant availability and increase power output. This paper describes recent experience in qualifying digital systems for safety applications. Also, described is the work currently in hand to reduce the frequency of maintenance periods for safety C ampersand I equipment. The qualification of digital systems is shown to be a more rigorous and much more extensive (and thus costly) exercise than the qualification of conventional equipment. This is illustrated by brief references to two software-based safety systems, the Single Channel Trip System at the Dungeness open-quotes Bclose quotesAGR and the Primary Protection System for the new PWR at Sizewell open-quotes Bclose quotes. The emphasis of the paper is on the use of Application Specific Integrated Circuits (ASICs) in safety systems, to reduce, or eliminate dependence on software for the fulfillment of requirements which need implementations that are complex or of a high functional density. Recent experience in the development of a prototype safety system based on ASICs, The Gaseous Activity Monitor and Trip Equipment (GAM), is used to illustrate their possible benefits and potential problems. When using complex integrated circuits like microprocessors or ASICs in digital systems a difficulty arises in analyzing the failure modes of the system. Efforts to overcome this difficulty led to the development of a method for performing failure analyses based on functional blocks. The techniques and benefits of such an approach are outlined. Finally, efforts to reduce maintenance costs, yet at the same time enhance safety, are leading towards an extension of maintenance intervals, for some safety equipment, from 3 months to 4 months and also towards lengthening the period between AGR outages from 2 years to 3 years

  17. Maintenance Plan for the Hanford Immobilized Low-Activity Tank Waste Performance Assessment

    International Nuclear Information System (INIS)

    MANN, F.M.

    2000-01-01

    The plan for maintaining the Hanford Immobilized Low-Activity Tank Waste Performance Assessment (PA) is described. The plan includes expected work on PA reviews and revisions, waste reports, monitoring, other operational activities, etc

  18. Operation and maintenance in the FM Group

    CERN Document Server

    Pepinster, P

    2003-01-01

    2002 has been a transitory year for the operation and maintenance on the tertiary buildings at CERN. The implementation of one unique contract of Facilities Management was the major issue which led to the merging of several technical activities previously carried out through different contracts, for many years. This paper, written after the first eight months of FM activities, presents the distinctive features of the transition period, the main changes in the management of the contract related to the technical maintenance, and the main difficulties encountered. It finally gives figures showing the evolution of some key maintenance indicators from the past years to today, as far as the scope of each activity can be compared.

  19. What are the required maintenance and consolidation activities to run at design performance levels (injectors and LHC) until 2035?

    CERN Document Server

    Baird, S

    2014-01-01

    Assuming that Linac4 is connected to the PSB in LS2, we will outline the maintenance and basic consolidation works that will be needed to maintain design performance of the LHC and its Injector chain until 2035, with an overall reliability as good as that achieved in the first LHC operation period 2009 to 2013. Using these data we will estimate the shutdown schedule needed throughout this period to complete these maintenance and consolidation works. These estimates will also include the required radiation cool-down periods, time for system re-commissioning and testing as well as the time needed to restart the accelerator chain for LHC colliding beam operation. As some of the consolidation activities needed for the PS and SPS machines are related to the radia tion dose taken by the machine equipment (e.g., irradiated cable replacement and magnet renovation) the variation of these time estimates as a function of beam losses in the Injector chain will also be covered.

  20. Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization

    Science.gov (United States)

    2014-01-01

    Background In the present study, we examined spinal glial cell activation as a central nervous system mechanism of widespread mechanical hyperalgesia in rats that experienced chronic post-cast pain (CPCP) 2 weeks after cast immobilization. Activated spinal microglia and astrocytes were investigated immunohistologically in lumbar and coccygeal spinal cord segments 1 day, 5 weeks, and 13 weeks following cast removal. Results In the lumbar cord, astrocytes were activated after microglia. Astrocytes also were activated after microglia in the coccygeal cord, but with a delay that was longer than that observed in the lumbar cord. This activation pattern paralleled the observation that mechanical hyperalgesia occurred in the hindleg or the hindpaw before the tail. The activating transcription factor 3 (ATF3) immune response in dorsal root ganglia (DRG) on the last day of cast immobilization suggested that nerve damage might not occur in CPCP rats. The neural activation assessed by the phosphorylated extracellular signal-regulated kinase (pERK) immune response in DRG arose 1 day after cast removal. In addition, L-α-aminoadipate (L-α-AA), an inhibitor of astrocyte activation administered intrathecally 5 weeks after cast removal, inhibited mechanical hyperalgesia in several body parts including the lower leg skin and muscles bilaterally, hindpaws, and tail. Conclusions These findings suggest that activation of lumbar cord astrocytes is an important factor in widespread mechanical hyperalgesia in CPCP. PMID:24456903

  1. Maintenance of neural activities in torpid Rhinolophus ferrumequinum bats revealed by 2D gel-based proteome analysis.

    Science.gov (United States)

    Yin, Qiuyuan; Zhang, Yijian; Dong, Dong; Lei, Ming; Zhang, Shuyi; Liao, Chen-Chung; Pan, Yi-Hsuan

    2017-08-01

    Bats are the only mammals capable of self-powered flying. Many bat species hibernate in winter. A reversible control of cerebral activities is critical for bats to accommodate a repeated torpor-arousal cycle during hibernation. Little is known about the molecular mechanisms that regulate neuronal activities in torpid bats. In this study, Rhinolophus ferrumequinum bat brain proteins were fractionated, and their abundance in active and torpid states was compared. Results of 2D gel-based proteomics showed that 38% of identified proteins with a significant change in abundance are involved in synaptic vesicle recycling and cytoskeletal integrity. Changes in the abundance of proteins related to RNA splicing, proteostasis, redox homeostasis, mitochondrial function, and energy metabolism were also detected. In addition, the levels of GNAO1 (guanine nucleotide-binding protein G αo subunit), an important modulator of neuronal transmembrane signaling, were significantly increased in the insoluble protein fraction of torpid bats; this may be due to GNAO1 palmitoylation making it insoluble. Our data provide molecular evidence for the maintenance of neuronal activities in torpid bats and suggest that a reversible palmitoylation of the G protein plays a role in the regulation of neuronal activities during bat hibernation. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Attentional orienting to mnemonic representations: reduction of load-sensitive maintenance-related activity in the intraparietal sulcus.

    Science.gov (United States)

    Trapp, Sabrina; Lepsien, Jöran

    2012-10-01

    The orienting of attention to internal or mnemonic representations held in visual working memory (VWM) has recently become a field of increasing interest. While a number of studies support the hypothesis that attention to selected representations in VWM reduces memory load, conclusive findings are still missing. In this event-related functional magnetic resonance imaging (fMRI) study, we directly investigated whether attentional orienting to mnemonic representations reduces activity in VWM storage-related areas of the brain. VWM load was manipulated by asking subjects to memorize two, four or six items. A retro-cue during the subsequent delay period asked subjects to attend to just one of these items for a subsequent test. This was compared to trials where subjects were required to continue attending to all items for the subsequent test. Data show reduction of load-sensitive maintenance-related activity along the right intraparietal sulcus (IPS), directly linked to attentional orienting. While activity in the anterior IPS reflected the number of representations in the focus of attention, the activation pattern in the posterior IPS suggested residual activation related to unattended items. This dissociation is in line with a functional subdivision of the right IPS according to attentional and mnemonic properties. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Automated Methodologies for the Design of Flow Diagrams for Development and Maintenance Activities

    Science.gov (United States)

    Shivanand M., Handigund; Shweta, Bhat

    The Software Requirements Specification (SRS) of the organization is a text document prepared by strategic management incorporating the requirements of the organization. These requirements of ongoing business/ project development process involve the software tools, the hardware devices, the manual procedures, the application programs and the communication commands. These components are appropriately ordered for achieving the mission of the concerned process both in the project development and the ongoing business processes, in different flow diagrams viz. activity chart, workflow diagram, activity diagram, component diagram and deployment diagram. This paper proposes two generic, automatic methodologies for the design of various flow diagrams of (i) project development activities, (ii) ongoing business process. The methodologies also resolve the ensuing deadlocks in the flow diagrams and determine the critical paths for the activity chart. Though both methodologies are independent, each complements other in authenticating its correctness and completeness.

  4. Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance.

    Science.gov (United States)

    Jouy, Florent; Müller, Stephan A; Wagner, Juliane; Otto, Wolfgang; von Bergen, Martin; Tomm, Janina M

    2015-01-01

    Recent years have seen a constant development of tools for the global assessment of phosphoproteins. Here, we outline a concept for integrating approaches for quantitative proteomics and phosphoproteomics. The strategy was applied to the analysis of changes in signalling and protein synthesis occurring after activation of the T-cell receptor (TCR) pathway in a T-cell line (Jurkat cells). For this purpose, peptides were obtained from four biological replicates of activated and control Jurkat T-cells and phosphopeptides enriched via a TiO2-based chromatographic step. Both phosphopeptide-enriched and flow-through fractions were analyzed by LC-MS. We observed 1314 phosphopeptides in the enriched fraction whereas 19 were detected in the flow-through, enabling the quantification of 414 and eight phosphoproteins in the respective fractions. Pathway analysis revealed the differential regulation of many metabolic pathways. Among the quantified proteins, 11 kinases with known TCR-related function were detected. A kinase-substrate database search for the phosphosites identified also confirmed the activity of a further ten kinases. In total, these two approaches provided evidence of 19 unique TCR-related kinases. The combination of phosphoproteomics and conventional quantitative shotgun analysis leads to a more comprehensive assessment of the signalling networks needed for the maintenance of the activated status of Jurkat T-cells. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development.

    Science.gov (United States)

    Zacharias, Amanda L; Gage, Philip J

    2010-12-01

    Pitx2 is a paired-like homeodomain gene that acts as a key regulator of eye development. Despite its significance, upstream regulation of Pitx2 expression during eye development remains incompletely understood. We use neural crest-specific ablation of Ctnnb1 to demonstrate that canonical Wnt signaling is not required for initial activation of Pitx2 in neural crest. However, canonical Wnt signaling is subsequently required to maintain Pitx2 expression in the neural crest. Eye development in Ctnnb1-null mice appears grossly normal early but significant phenotypes emerge following loss of Pitx2 expression. LEF-1 and β-catenin bind Pitx2 promoter sequences in ocular neural crest, indicating a likely direct effect of canonical Wnt signaling on Pitx2 expression. Combining our data with previous reports, we propose a model wherein a sequential code of retinoic acid followed by canonical Wnt signaling are required for activation and maintenance of Pitx2 expression, respectively. Other key transcription factors in the neural crest, including Foxc1, do not require intact canonical Wnt signaling. Copyright © 2010 Wiley-Liss, Inc.

  6. Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency

    DEFF Research Database (Denmark)

    Hammachi, Fella; Morrison, Gillian M; Sharov, Alexei A

    2012-01-01

    Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant...... and in vitro. An Oct4 activation domain fusion supported embryonic stem cell self-renewal in vitro at lower concentrations than that required for Oct4 while alleviating the ordinary requirement for the cytokine LIF. At still lower levels of the fusion, LIF dependence was restored. We conclude...

  7. Disclosing the registration information and maintenance of a transparency of activity in the conditions

    OpenAIRE

    Golubnicha, G.

    2010-01-01

    Historical stages of development of the accounting information which contains in the financial reporting are investigated. It is considered disclosing the accounting information as its such modern qualitative characteristic which creates possibility to provide an activity transparency in the financial and commodity markets in the conditions of globalisation.

  8. Behavioural decisions of travel-time ratios for work, maintenance and leisure activities in the Netherlands.

    NARCIS (Netherlands)

    Susilo, Y.S.; Dijst, M.J.

    2010-01-01

    Using the 2005 Dutch National Travel Survey data-set this paper investigates the influences of socio-demographics, journey patterns and built environment factors on the ratio of travel time and activity duration that an individual spends when engaging in work, daily shopping, non-daily shopping

  9. SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview.

    Science.gov (United States)

    Monteiro, Jomar Patricio; Cano, Maria Isabel Nogueira

    2011-02-01

    The present review intends to summarize the, yet preliminary, but very important emerging data underlining the functions exerted by the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase SIRT1 on protein homeostasis. The main focus of the discussion is the cooperation between SIRT1 and the heat shock factor 1 (HSF1) responsible for activating the transcription of molecular chaperones, the protein-protective factors that resolve damaged/misfolded and aggregated proteins generated by heat stress or metabolism. SIRT1, a mammalian ortholog of the yeast silent information regulator 2, is a stress activated protein deacetylase that contributes to life-span extension by regulating different cell survival pathways, including replicative senescence, inflammation and resistance to hypoxic and heat stress. Phosphorylation is the major mechanism controlling the level and function of SIRT1 required for normal cell cycle progression and cell survival under stress conditions. Phosphorylated SIRT1 deacetylates and coactivates different substrates, including HSF1. Deacetylated HSF1 binds to the heat shock promoter element found upstream of genes encoding molecular chaperones. Overexpression of SIRT1 in cultured cells also helps them to survive exposure to heat stress. Conversely, its down-regulation accelerates the attenuation of the heat shock response promoting the release of HSF1 from its cognate promoter element. Very recently, in a mouse model for Alzheimer's disease, SIRT1 deacetylase activity was also found activating the transcription of α-secretase, the enzyme responsible for inhibiting the formation of aggregates of neuronal β-amyloid plaques. How SIRT1 activity protects cells from the deleterious effects of damaged/misfolded proteins and the implication of these findings on age-related pathologies are discussed.

  10. Regulatory inspection activities related to inspection planning, plant maintenance and assessment of safety. Proceedings of an international workshop

    International Nuclear Information System (INIS)

    Van Binnebeek, J.J.; Aubrey, Richard; Grandame, Melvyn; Aro, Ilari; Balloffet, Yves; Klonk, Hartmut; Manzella, Pietro; Koizumi, Hiroyoshi; Bouvrie, E.C. des; Forsberg, Staffan; Lang, Hans-Guenter; Mehew, Robert; Warren, Thomas; Woodhouse, Paul; Gallo, Robert M.; Campbell, Rob; )

    1997-01-01

    The NEA Committee on Nuclear Regulatory Activities (CNRA) believes that an essential factor in ensuring the safety of nuclear installations is the continuing exchange and analysis of technical information and data. To facilitate this exchange the Committee has established Working Groups and Groups of Experts in specialised topics. CNRA believes that safety inspections are a major element in the regulatory authority's efforts to ensure the safe operation of nuclear facilities. Considering the importance of these issues, the Committee has established a special Working Group on Inspection Practices (WGIP). The purpose of WGIP, is to facilitate the exchange of information and experience related to regulatory safety inspections between CNRA Member countries. This was the 3. international workshop held by the WGIP on regulatory inspection activities. The focus of this workshop was on 3 main topics; Inspection Planning, Plant Maintenance and Assessment of Safety. This document presents the proceedings from the workshop, including: workshop programme, results and conclusions, papers and presentations and the list of participants. The main purpose of the Workshop is to provide a forum of exchange of information on the regulatory inspection activities

  11. Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma.

    Science.gov (United States)

    Yang, H; Kircher, D A; Kim, K H; Grossmann, A H; VanBrocklin, M W; Holmen, S L; Robinson, J P

    2017-07-06

    The development of targeted inhibitors, vemurafenib and dabrafenib, has led to improved clinical outcome for melanoma patients with BRAF V600E mutations. Although the initial response to these inhibitors can be dramatic, sometimes causing complete tumor regression, the majority of melanomas eventually become resistant. Mitogen-activated protein kinase kinase (MEK) mutations are found in primary melanomas and frequently reported in BRAF melanomas that develop resistance to targeted therapy; however, melanoma is a molecularly heterogeneous cancer, and which mutations are drivers and which are passengers remains to be determined. In this study, we demonstrate that in BRAF V600E melanoma cell lines, activating MEK mutations drive resistance and contribute to suboptimal growth of melanoma cells following the withdrawal of BRAF inhibition. In this manner, the cells are drug-addicted, suggesting that melanoma cells evolve a 'just right' level of mitogen-activated protein kinase signaling and the additive effects of MEK and BRAF mutations are counterproductive. We also used a novel mouse model of melanoma to demonstrate that several of these MEK mutants promote the development, growth and maintenance of melanoma in vivo in the context of Cdkn2a and Pten loss. By utilizing a genetic approach to control mutant MEK expression in vivo, we were able to induce tumor regression and significantly increase survival; however, after a long latency, all tumors subsequently became resistant. These data suggest that resistance to BRAF or MEK inhibitors is probably inevitable, and novel therapeutic approaches are needed to target dormant tumors.

  12. Research and development strategy and maintenance engineering to strengthen the basis of ageing management. International activities

    International Nuclear Information System (INIS)

    Sekimura, Naoto

    2009-01-01

    Systematic development of information basis for database and knowledge-base has been performed in addition to the development of codes and standards by academic societies, regulatory bodies and industries through the intensive domestic safety research collaborations and international collaboration, through the continuous revision of Strategy Maps for Ageing Management and Safe Long Term Operation. Important international activities in IAEA and OECD/NEA especially for knowledge-base and extraction of commendable practices in ageing management are discussed. (author)

  13. PREVIOUS SECOND TRIMESTER ABORTION

    African Journals Online (AJOL)

    PNLC

    PREVIOUS SECOND TRIMESTER ABORTION: A risk factor for third trimester uterine rupture in three ... for accurate diagnosis of uterine rupture. KEY WORDS: Induced second trimester abortion - Previous uterine surgery - Uterine rupture. ..... scarred uterus during second trimester misoprostol- induced labour for a missed ...

  14. The first maintenance operations in active cells with an innovative tele-robotic system at AREVA NC recycling plant

    Energy Technology Data Exchange (ETDEWEB)

    Coudray, A. [AREVA-MECACHIMIE, Rue de Millecent, F-50440 Beaumont Hague (France); Piolain, G. [AREVA-NC (France); Geffard, F. [Commissariat a l' Energie Atomique - CEA (France)

    2009-06-15

    A few years ago, AREVA NC, started an ambitious Research and Development program in robotics and remote technologies applied to its spent fuel management facilities in France in order to cover the requirements of the different plant life cycles. This program has been carried out in collaboration with the CEA in charge of the conceptual design, as well as of the development of the prototypes, and with MECACHIMIE, a subsidiary of AREVA NC, in charge of the industrial integration. The innovative remote device has been designed and qualified to use a standard industrial robot which has been transformed into a slave tele-manipulator. This publication presents two applications in a high level activity area of the nuclear facility that used the innovative remote handling system in maintenance operations, located at the shearing and dissolution T1 and R1 facilities of the La Hague recycling plant. The purpose of these maintenance operations is to remove the rollers of the dissolver and to clean the inter bucket spaces of the wheel of the dissolver in the high level activity area of the La Hague nuclear facility. The first application imposes the use of a power slave arm system. AREVA NC has realized this operation, at the end of 2005 on T1 facility and in the beginning of 2008 on R1 facility, with the same equipment. This operation requires a remote handling mode with a force feedback in order to get enough dexterity. In 2009, the same equipment will be used to realize the cleaning of the inter bucket spaces of the wheel dissolver with high pressure water. The main challenges to face are the following ones: - access to the area is not allowed due to high radiation level - access to the inter bucket is very difficult with the conventional master/slave tele-manipulators - the use of the camera is not possible during the cleaning operation - the generated quantity of effluents has to be optimized Thus, this operation has to be realized from automated trajectories. For that

  15. Mirror activity in the human brain while observing hand movements: a comparison between EEG desynchronization in the mu-range and previous fMRI results.

    Science.gov (United States)

    Perry, Anat; Bentin, Shlomo

    2009-07-28

    Mu (mu) rhythms are EEG oscillations between 8-13 Hz distinguished from alpha by having more anterior distribution and being desynchronized by motor rather than visual activity. Evidence accumulating during the last decade suggests that the desynchronization of mu rhythms (mu suppression) might be also a manifestation of a human Mirror Neuron System (MNS). To further explore this hypothesis we used a paradigm that, in a previous fMRI study, successfully activated this putative MNS in humans. Our direct goal was to provide further support for a link between modulation of mu rhythms and the MNS, by finding parallels between the reported patterns of fMRI activations and patterns of mu suppression. The EEG power in the mu range has been recorded while participants passively observed either a left or a right hand, reaching to and grasping objects, and compared it with that recorded while participants observed the movement of a ball, and while observing static grasping scenes or still objects. Mirroring fMRI results (Shmuelof, L., Zohary, E., 2005. Dissociation between ventral and dorsal fMRI activation during object and action recognition. Neuron 47, 457-470), mu suppression was larger in the hemisphere contra-lateral to the moving hand and larger when the hands grasped different objects in different ways than when the movement was repetitive. No suppression was found while participants observed still objects but mu suppression was also found while seeing static grasping postures. These data are discussed in light of similar parallels between modulations of alpha waves and fMRI while recording EEG in the magnet. The present data support a link between mu suppression and a human MNS.

  16. Maintenance Mentor

    National Research Council Canada - National Science Library

    Jacobs, John

    2003-01-01

    Maintenance Mentor (MXM) is a research effort conducted by a joint AFRL/HESR and Northrop Grumman Information Technology team to identify the basic, high-level requirements necessary for improving flight line diagnostic capabilities...

  17. Neural activation patterns of successful episodic encoding: Reorganization during childhood, maintenance in old age

    Directory of Open Access Journals (Sweden)

    Yee Lee Shing

    2016-08-01

    Full Text Available The two-component framework of episodic memory (EM development posits that the contributions of medial temporal lobe (MTL and prefrontal cortex (PFC to successful encoding differ across the lifespan. To test the framework’s hypotheses, we compared subsequent memory effects (SME of 10–12 year-old children, younger adults, and older adults using functional magnetic resonance imaging (fMRI. Memory was probed by cued recall, and SME were defined as regional activation differences during encoding between subsequently correctly recalled versus omitted items. In MTL areas, children’s SME did not differ in magnitude from those of younger and older adults. In contrast, children’s SME in PFC were weaker than the corresponding SME in younger and older adults, in line with the hypothesis that PFC contributes less to successful encoding in childhood. Differences in SME between younger and older adults were negligible. The present results suggest that, among individuals with high memory functioning, the neural circuitry contributing to successful episodic encoding is reorganized from middle childhood to adulthood. Successful episodic encoding in later adulthood, however, is characterized by the ability to maintain the activation patterns that emerged in young adulthood.

  18. NOTCH activity differentially affects pituitary endocrine cell fate acquisition and maintenance.

    Science.gov (United States)

    Cheung, Leonard; Le Tissier, Paul; Goldsmith, Sam Gj; Treier, Mathias; Lovell-Badge, Robin; Rizzoti, Karine

    2018-03-26

    The pituitary is an essential endocrine gland regulating multiple processes. Regeneration of endocrine cells is of therapeutic interest and recent studies are promising, but mechanisms of endocrine cell fate acquisition need to be better characterised. The NOTCH pathway is important during pituitary development. Here, we further characterise its role in the murine pituitary, revealing differential sensitivity within and between lineages. In progenitors, NOTCH activation blocks cell fate acquisition, with time-dependant modulation. In differentiating cells, response to activation is blunted in the POU1F1 lineage, with apparently normal cell fate specification, while POMC cells remain sensitive. Absence of apparent defects in Pou1f1-Cre; Rbpj fl/fl mice further suggests no direct role for NOTCH signalling in POU1F1 cell fate acquisition. In contrast, in the POMC lineage, NICD expression induces a regression towards a progenitor-like state, suggesting that the NOTCH pathway specifically blocks POMC cell differentiation. These results have implications for pituitary development, plasticity and regeneration. © 2018, Cheung et al.

  19. Breast cancer survivors involved in vigorous team physical activity: psychosocial correlates of maintenance participation.

    Science.gov (United States)

    Culos-Reed, S Nicole; Shields, Christopher; Brawley, Lawrence R

    2005-07-01

    Physical activity is increasingly being promoted as a means to achieve both physical and psychological benefits for cancer survivors. For women with breast cancer, one sport growing in popularity is dragon boating. The purpose of the present investigation was to examine the psychosocial correlates of dragon boat participation over the course of a season. Six crews completed the baseline (early-season) assessment (n = 109) and late-season assessments (n = 56). The self-report questionnaire completed at both time points included an assessment of the theory of planned behaviour variables, quality of life, cohesion, and physical activity levels. A prospective examination of the TPB variables revealed attitude at early season as the only significant predictor of behavioural intentions 12 weeks later at late season (R2 adjusted = 0.27, p sport teams among the asymptomatic population. As well, participants' health-related quality of life was similar to normal, healthy women of similar age for both mental and physical health. Copyright 2004 John Wiley & Sons, Ltd.

  20. Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding

    Directory of Open Access Journals (Sweden)

    Brewster Aaron S

    2010-08-01

    Full Text Available Abstract Background The mini-chromosome maintenance protein (MCM complex is an essential replicative helicase for DNA replication in Archaea and Eukaryotes. While the eukaryotic complex consists of six homologous proteins (MCM2-7, the archaeon Sulfolobus solfataricus has only one MCM protein (ssoMCM, six subunits of which form a homohexamer. We have recently reported a 4.35Å crystal structure of the near full-length ssoMCM. The structure reveals a total of four β-hairpins per subunit, three of which are located within the main channel or side channels of the ssoMCM hexamer model generated based on the symmetry of the N-terminal Methanothermobacter thermautotrophicus (mtMCM structure. The fourth β-hairpin, however, is located on the exterior of the hexamer, near the exit of the putative side channels and next to the ATP binding pocket. Results In order to better understand this hairpin's role in DNA binding and helicase activity, we performed a detailed mutational and biochemical analysis of nine residues on this exterior β-hairpin (EXT-hp. We examined the activities of the mutants related to their helicase function, including hexamerization, ATPase, DNA binding and helicase activities. The assays showed that some of the residues on this EXT-hp play a role for DNA binding as well as for helicase activity. Conclusions These results implicate several current theories regarding helicase activity by this critical hexameric enzyme. As the data suggest that EXT-hp is involved in DNA binding, the results reported here imply that the EXT-hp located near the exterior exit of the side channels may play a role in contacting DNA substrate in a manner that affects DNA unwinding.

  1. Normalization of EEG activity among previously institutionalized children placed into foster care: A 12-year follow-up of the Bucharest Early Intervention Project

    Directory of Open Access Journals (Sweden)

    Ross E. Vanderwert

    2016-02-01

    Full Text Available Extreme social and cognitive deprivation as a result of institutional care has profound effects on developmental outcomes across multiple domains for many abandoned or orphaned children. The Bucharest Early Intervention Project (BEIP examines the outcomes for children originally placed in institutions who were assessed comprehensively and then randomized to foster care (FCG or care as usual (CAUG and followed longitudinally. Here we report on the brain electrical activity (electroencephalogram: EEG of 12-year-old children enrolled in the BEIP. Previous reports suggested improvement in resting EEG activity for the group of children placed in the foster care intervention, particularly those placed before 24 months of age compared to children who were randomized to CAUG or those placed into families after this age. At 12 years, differences between those in the FCG and those in the CAUG persist in the alpha band (8–13 Hz, but not in higher frequency bands (i.e. in the beta band; 15–30 Hz, except in those children placed into the FCG who remained in high quality care environments over the course of the study. These findings highlight the importance of maintaining a stable high quality caregiving environment, particularly for children exposed to early psychosocial deprivation, for promoting healthy brain development.

  2. Heart rate, salivary α-amylase activity, and cooperative behavior in previously naïve children receiving dental local anesthesia.

    Science.gov (United States)

    Arhakis, Aristidis; Menexes, George; Coolidge, Trilby; Kalfas, Sotirios

    2012-01-01

    Psychosomatic indicators, such as heart rate (HR), salivary alpha amylase (sAA) activity, and behavior, can be used to determine stress. This study's aim was to assess the pattern of changes of salivary alpha amylase, heart rate, and cooperative behavior in previously naïve children receiving dental treatment under local anesthesia. Included were 30 children with no prior dental experience who needed 4 or more sessions of dental treatment involving local anesthesia. In each session, sAA, HR, and behavior were assessed before and during the application of local anesthesia and at the end of the treatment. The highest sAA value was always observed at the end of each session; overall, the value was lower in the fourth session. HR always increased during the local anesthesia, and did not vary across sessions. No significant relationship was found between child cooperation and either sAA or HR. In this sample, child cooperation may not be an accurate indicator of stress. Based on salivary alpha amylase activity changes, dental treatment involving local anesthesia in naïve children appeared to be less stressful after 3 sessions.

  3. Normalization of EEG activity among previously institutionalized children placed into foster care: A 12-year follow-up of the Bucharest Early Intervention Project.

    Science.gov (United States)

    Vanderwert, Ross E; Zeanah, Charles H; Fox, Nathan A; Nelson, Charles A

    2016-02-01

    Extreme social and cognitive deprivation as a result of institutional care has profound effects on developmental outcomes across multiple domains for many abandoned or orphaned children. The Bucharest Early Intervention Project (BEIP) examines the outcomes for children originally placed in institutions who were assessed comprehensively and then randomized to foster care (FCG) or care as usual (CAUG) and followed longitudinally. Here we report on the brain electrical activity (electroencephalogram: EEG) of 12-year-old children enrolled in the BEIP. Previous reports suggested improvement in resting EEG activity for the group of children placed in the foster care intervention, particularly those placed before 24 months of age compared to children who were randomized to CAUG or those placed into families after this age. At 12 years, differences between those in the FCG and those in the CAUG persist in the alpha band (8-13 Hz), but not in higher frequency bands (i.e. in the beta band; 15-30 Hz), except in those children placed into the FCG who remained in high quality care environments over the course of the study. These findings highlight the importance of maintaining a stable high quality caregiving environment, particularly for children exposed to early psychosocial deprivation, for promoting healthy brain development. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    International Nuclear Information System (INIS)

    Rivero, Javier; Luzardo, Octavio P.; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-01-01

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  5. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Javier; Luzardo, Octavio P., E-mail: octavio.perez@ulpgc.es; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-12-15

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  6. THE IMAGE MAINTENANCE OF PURWAKARTA REGENT THROUGH GEMPUNGAN ACTIVITIES IN PURWAKARTA REGENCY

    Directory of Open Access Journals (Sweden)

    Anggita Herladiati

    2016-06-01

    Full Text Available Abstrack, Gempungan is an implementation of Purwakartagovernment program contained in "Salapan Lengkah Ngawangun Nagri Raharja". In general, this activity is a form of service to the community that is "proactive", where services are provided in the form of administrative services of residence (KTP, KK, Birth Certificate, Book of Marriage and others, health services, blood donor, family planning services, mass circumcision, as well as input from religious leaders, community leaders and citizens as a whole. This activity is done once a week turning in 192 villages in the district of Purwakarta. The event ended with the "Ngahajatan urang overtime" show that held at night, filled with arts and entertainment event which is dedicated to citizens. This study aims to determine how Purwakarta Regent, Dedi Mulyadi namely imaging through Gempungan activities In Purwakarta district. The research method used in this research on imaging Purwakarta Regent through Gempungan In Purwakarta is qualitative method research with explorative case study approach. Data in this study were obtained through direct observation, interviews, and review of the literature and documents. The results showed that the activitiesof Gempungan made by Regent Dedi Mulyadi invented by people’s aspirationsthat have not been fulfilled by Purwakarta Government. In addition to the Gempunganactivities, Regent Dedi Mulyadi be able to know more about what kind of condition and the community needs so that the programs created by local government will be more effective and efficient. The community responded Gempungan activitiesas very positive, and the majority also stated that the Regent Dedi Mulyadi is a figure that highly regard the welfare of society and one of the best Regent,Purwakartaever owned.     Abstrak, Gempungan adalah implementasi dari program pemerintah purwakarta yang tertuang dalam“Salapan Lengkah Ngawangun Nagri Raharja”. Secara umum kegiatan ini merupakan bentuk

  7. Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1.

    Science.gov (United States)

    Solanes, Paola; Heuzé, Mélina L; Maurin, Mathieu; Bretou, Marine; Lautenschlaeger, Franziska; Maiuri, Paolo; Terriac, Emmanuel; Thoulouze, Maria-Isabel; Launay, Pierre; Piel, Matthieu; Vargas, Pablo; Lennon-Duménil, Ana-Maria

    2015-03-12

    Dendritic cells (DCs) patrol the interstitial space of peripheral tissues. The mechanisms that regulate their migration in such constrained environment remain unknown. We here investigated the role of calcium in immature DCs migrating in confinement. We found that they displayed calcium oscillations that were independent of extracellular calcium and more frequently observed in DCs undergoing strong speed fluctuations. In these cells, calcium spikes were associated with fast motility phases. IP₃ receptors (IP₃Rs) channels, which allow calcium release from the endoplasmic reticulum, were identified as required for immature DCs to migrate at fast speed. The IP₃R1 isoform was further shown to specifically regulate the locomotion persistence of immature DCs, that is, their capacity to maintain directional migration. This function of IP₃R1 results from its ability to control the phosphorylation levels of myosin II regulatory light chain (MLC) and the back/front polarization of the motor protein. We propose that by upholding myosin II activity, constitutive calcium release from the ER through IP₃R1 maintains DC polarity during migration in confinement, facilitating the exploration of their environment. © 2015 Institut Curie/Inserm. Published under the terms of the CC BY NC ND 4.0 license.

  8. Artificial oocyte activation to improve reproductive outcomes in women with previous fertilization failure: a systematic review and meta-analysis of RCTs.

    Science.gov (United States)

    Sfontouris, Ioannis A; Nastri, Carolina O; Lima, Maria L S; Tahmasbpourmarzouni, Eisa; Raine-Fenning, Nick; Martins, Wellington P

    2015-08-01

    In couples with previous fertilization failure, are reproductive outcomes improved using ICSI followed by artificial oocyte activation (ICSI-AOA) compared with conventional ICSI? There is insufficient evidence available from RCTs to judge the efficacy and safety of ICSI-AOA for couples with previous fertilization failure. In cases with previous low fertilization rates or total fertilization failure using ICSI due to sperm-related, oocyte activation deficiency, several methods of AOA have been described, which employ mechanical, electrical or chemical stimuli. Reported fertilization and pregnancy rates appear to be improved after ICSI-AOA compared with conventional ICSI; however, the small studies performed to date make it difficult to assess the clinical efficacy or safety of AOA. The present systematic review and meta-analysis identified RCTs that compared ICSI-AOA and conventional ICSI. The last electronic search was conducted in August 2014 and there was no limitation regarding language, publication date, or publication status. We included studies that randomized either oocytes or women and included them in two different parts of this review: a women-based review and an oocyte-based review. For the women-based review, the primary outcome of effectiveness was live birth per randomized woman and the primary outcome for safety was congenital anomalies per clinical pregnancy. For the oocyte-based review, the primary outcome was embryo formation per oocyte randomized. Record screening and data extraction were performed independently by two authors and risk of bias was assessed by three authors. The effects of ICSI-AOA compared with conventional ICSI were summarized as risk ratio (RR) and the precision of the estimates was evaluated by the 95% confidence interval (CI). A total of 14 articles were assessed for eligibility and 9 included in the meta-analysis: 2 studies comprised the woman-based review (n = 168 women) and 7 studies the oocyte-based review (n = 4234

  9. Managed maintenance, the next step in power plant maintenance

    International Nuclear Information System (INIS)

    Butterworth, G.; Anderson, T.M.

    1984-01-01

    The Westinghouse Nuclear Services Integration Division managed maintenance services are described. Essential to the management and control of a total plant maintenance programme is the development of a comprehensive maintenance specification. During recent years Westinghouse has jointly developed total plant engineering-based maintenance specifications with a number of utilities. The process employed and the experience to date are described. To efficiently implement the maintenance programme Westinghouse has developed a computer software program specifically designed for day to day use at the power plant by maintenance personnel. This program retains an equipment maintenance history, schedules maintenance activities, issues work orders and performs a number of sophisticated analyses of the maintenance backlog and forecast, equipment failure rates, etc. The functions of this software program are described and details of Westinghouse efforts to support the utilities in reducing outage times through development of predefined outage plans for critical report maintenance activities are given. Also described is the experience gained in the training of specialized maintenance personnel, employing competency-based training techniques and equipment mock-ups, and the benefits experienced, in terms of improved quality and productivity of maintenance performed. The success experienced with these methods has caused Westinghouse to expand the use of these training techniques to the more routine skill areas of power plant maintenance. A significant reduction in the operating costs of nuclear power plants will only be brought about by a significant improvement in the quality of maintenance. Westinghouse intends to effect this change by expanding its international service capabilities and to make major investments in order to promote technological developments in the area of power plant maintenance. (author)

  10. IT capabilities in ERP maintenance

    OpenAIRE

    Hecht, Sonja;Wittges, Holger;Krcmar, Helmut

    2014-01-01

    With the maturing use of ERP systems, the management of their post-implementation phase is receiving increased attention. There is a need to understand how to manage post-implementation activities like ERP maintenance. ERP maintenance is a critical IT service provided by IT organizations in the ERP post-implementation phase, including activities to support and extend existing ERP systems. The extant research has focused on tasks related to ERP maintenance, but it lacks studies that provide in...

  11. {sup 177}Lu-octreotate, alone or with radiosensitising chemotherapy, is safe in neuroendocrine tumour patients previously treated with high-activity {sup 111}In-octreotide

    Energy Technology Data Exchange (ETDEWEB)

    Hubble, Daniel; Kong, Grace; Michael, Michael; Johnson, Val; Ramdave, Shakher; Hicks, Rodney John [Peter MacCallum Cancer Centre, Centre for Molecular Imaging, East Melbourne, VIC (Australia)

    2010-10-15

    The aim of this retrospective study was to determine whether patients with previous peptide receptor radionuclide therapy using high-activity {sup 111}In-pentetreotide can be safely treated with {sup 177}Lu-octreotate and whether addition of radiosensitising chemotherapy increases the toxicity of this agent. Records of 27 patients (aged 17-75) who received 69 (median 3 per patient) {sup 177}Lu-octreotate administrations, including 29 in conjunction with radiosensitising infusional 5-fluorouracil (5-FU) (n = 27), or capecitabine (n = 2), between October 2005 and July 2007 subsequent to 1-8 prior cycles of {sup 111}In-pentetreotide therapy were analysed. Toxicity was assessed during and at 8-12 weeks post-treatment, with further long-term assessments including survival status reviewed till death or study close-out date of 1 November 2009. Reduction in blood counts was most marked following the first dose of {sup 177}Lu-octreotate but at early follow-up the only major haematological toxicity was a single case of grade 4 lymphopaenia. Both the presence of bone metastases and the administration of chemotherapy tended to result in greater reduction in blood counts, but these differences did not reach statistical significance. On long-term follow-up, 16 patients (59%) are alive with median overall survival of 36 months (32-44 months from first {sup 177}Lu-octreotate therapy). None of the recorded deaths was directly related to treatment toxicity. One patient had late grade 4 anaemia and thrombocytopaenia secondary to bone marrow failure from progressive infiltration by tumour. No other significant long-term haematological toxicities were recorded and no leukaemia was observed. No renal toxicity was observed on serial serum creatinine or radionuclide glomerular filtration rate (GFR) determination on initial or long-term follow-up. {sup 177}Lu-octreotate is a safe and well-tolerated therapy for patients who have previously been treated with {sup 111}In-pentetreotide and can

  12. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  13. Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Yi-Nan Li

    2016-06-01

    Full Text Available Objective: Maintenance hemodialysis (MHD patients often have impaired quality of life (QOL, anxiety, depression, and reduced daily physical activity (DPA and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance. Methods: Seventy-two relatively healthy adult MHD patients, vintage ≥6 months, and 39 normals of similar age range and gender distribution were studied. QOL was assessed using the Kidney Disease Quality of Life-Short Form (KDQOL-SF. Anxiety and depression were each evaluated with two questionnaires. DPA and physical performance were assessed with a physical activity monitor, Human Activity Profile, and 6-minute walk, sit-to-stand, and stair-climbing tests. Results: Most KDQOL components were reduced in MHD patients versus normals. KDQOL components in patients were commonly inversely correlated with measures of anxiety and depression (P < 0.05 and were more reduced in patients with both anxiety and depression. KDQOL was often impaired in patients with either anxiety or depression. However, most KDQOL scores did not differ between patients and normals without anxiety or depression. DPA, Human Activity Profile, and physical performance often correlated with KDQOL scores in adjusted models, but after further adjustment for anxiety and depression, DPA, Human Activity Profile, and physical performance correlated less frequently with KDQOL scores. This reduction in significant correlations after adjustment for anxiety and depression was particularly pronounced for the association between KDQOL and DPA. Conclusion: In relatively healthy MHD patients, KDQOL scores are usually decreased in those with anxiety and/or depression but are usually normal in those without anxiety or depression. Lower DPA in MHD patients with reduced KDQOL scores often appears to be associated with anxiety and

  14. Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction.

    Science.gov (United States)

    Ascione, Raimondo; Rowlinson, Jonathan; Avolio, Elisa; Katare, Rajesh; Meloni, Marco; Spencer, Helen L; Mangialardi, Giuseppe; Norris, Caroline; Kränkel, Nicolle; Spinetti, Gaia; Emanueli, Costanza; Madeddu, Paolo

    2015-04-11

    Chemokine-directed migration is crucial for homing of regenerative cells to the infarcted heart and correlates with outcomes of cell therapy trials. Hence, transplantation of chemokine-responsive bone marrow cells may be ideal for treatment of myocardial ischemia. To verify the therapeutic activity of bone marrow mononuclear cells (BM-MNCs) selected by in vitro migration towards the chemokine stromal cell-derived factor-1 (SDF-1) in a mouse model of myocardial infarction (MI), we used BM-MNCs from patients with previous large MI recruited in the TransACT-1&2 cell therapy trials. Unfractioned BM-MNCs, SDF-1-responsive, and SDF-1-nonresponsive BM-MNCs isolated by patients recruited in the TransACT-1&2 cell therapy trials were tested in Matrigel assay to evaluate angiogenic potential. Secretome and antigenic profile were characterized by flow cytometry. Angiogenin expression was measured by RT-PCR. Cells groups were also intramyocardially injected in an in vivo model of MI (8-week-old immune deficient CD1-FOXN1(nu/nu) mice). Echocardiography and hemodynamic measurements were performed before and at 14 days post-MI. Arterioles and capillaries density, infiltration of inflammatory cells, interstitial fibrosis, and cardiomyocyte proliferation and apoptosis were assessed by immunohistochemistry. In vitro migration enriched for monocytes, while CD34(+) and CD133(+) cells and T lymphocytes remained mainly confined in the non-migrated fraction. Unfractioned total BM-MNCs promoted angiogenesis on Matrigel more efficiently than migrated or non-migrated cells. In mice with induced MI, intramyocardial injection of unfractionated or migrated BM-MNCs was more effective in preserving cardiac contractility and pressure indexes than vehicle or non-migrated BM-MNCs. Moreover, unfractioned BM-MNCs enhanced neovascularization, whereas the migrated fraction was unique in reducing the infarct size and interstitial fibrosis. In vitro studies on isolated cardiomyocytes suggest participation

  15. Local cluster of germ cell cancer in a cohort of male automotive workers in Germany not explained by previous or concurrent activities and exposures in farming and forestry.

    Science.gov (United States)

    Schmeisser, N; Behrens, T; Mester, B; Gottlieb, A; Langner, I; Ahrens, W

    2011-02-01

    To examine whether exposures or activities in farming, forestry and related occupations explain the excess incidence of germ cell cancer (GCC) observed among male employees in one of the six car-manufacturing plants that is located in a geographic area where farming is frequent. A cohort based case-control study was conducted among workers in six car-manufacturing plants located in areas with different industrial structure. The study involved 188 cases of germ cell cancer identified through active retrieval in 38 hospitals and 1000 controls, drawn from administrative accounting files, individually matched by year of birth (± 2 years). Information regarding tasks and exposures and potential confounding variables were obtained by face-to-face or telephone interviews. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model adjusted for cryptorchidism and other potential confounders. In this case-control study 5.3% of cases and 6.3% of controls ever worked in agriculture or livestock farming. No increased risks were observed for working in agriculture (OR=0.8 95% CI: 0.4-1.6), livestock farming (OR=0.8 95% CI: 0.4-1.6) or for exposure to pesticides (OR=0.7 95% CI: 0.3-1.7), for exposure to fertilizers (OR=0.8 95% CI: 0.4-1.8) and disinfectants (OR=1.0 95% CI: 0.3-2.8). There were no statistically significant increases in risk associated with ever exposure to salt based wood protection agents (OR=2.3 95% CI: 0.6-9.1), working with plywood (OR=1.4 95% CI: 0.6-3.2), coated wood (OR=1.4 95% CI: 0.5-3.9) or working in forestry (OR=1.7 95% CI: 0.5-6.4). Lagging of exposures did not alter the results. The observed excess incidence in the cohort of automotive workers can be hardly explained by previous or concurrent work in farming or forestry. Because of the small numbers of subjects ever employed in farming the statistical power in assessing associations between agricultural work and agricultural exposures was limited

  16. Lifetime oriented maintenance planning in the Netherlands

    NARCIS (Netherlands)

    Straub, A.

    2003-01-01

    In this paper we set up a framework for lifetime oriented maintenance planning as an outcome and input for strategic housing stock management. The maintenance planning holds maintenance activities and costs in the longer term. We consider the maintenance planning as a tool to calculate and implement

  17. Systematic analysis and prevention of human originated common cause failures in relation to maintenance activities at Finnish nuclear power plants

    International Nuclear Information System (INIS)

    Laakso, K.

    2006-12-01

    The focus in human reliability analysis of nuclear power plants has traditionally been on human performance in disturbance conditions. On the other hand, human maintenance failures and design deficiencies, remained latent in the system, have an impact on the severity of a disturbance, e.g. by disabling safety-related equipment on demand. Especially common cause failures (CCFs) of safety related systems can affect the core damage risk to a significant extent. The topic has been addressed in Finnish studies, where experiences of latent human errors have been searched and analysed systematically from the maintenance history stored in the the power plant information systems of the Loviisa and Olkiluoto NPPs. Both the single and multiple errors (CCFs) were classified in detail and documented as error and event reports. The human CCFs involved human, organisational and technical factors. The review of the analysed single and multiple errors showed that instrumentation and control and electrical equipment are more prone to human error caused failure events than the other maintenance objects. The review of the analysed experience showed that most errors stem from the refuelling and maintenance outage periods. More than half of the multiple errors from the outages remained latent to the power operating periods. The review of the analysed multiple errors showed that difficulties with small plant modifications and planning of maintenance and operability were significant sources of common cause failures. The most dependent human errors originating from small modifications could be reduced by a more tailored planning and coverage of their start-up testing programs. Improvements could also be achieved by identifying better in work planning from the operating experiences those complex or intrusive repair and preventive maintenance work tasks and actions which are prone to errors. Such uncertain cases in important equipment require a more tailored work planning of the installation

  18. Application of reliability centred maintenance to optimize operation and maintenance in nuclear power plants

    International Nuclear Information System (INIS)

    2007-05-01

    In order to increase Member States capabilities in utilizing good engineering and management practices the Agency has developed a series of Technical Documents (TECDOCs) to describe best practices and members experience in the application of them. This TECDOC describes the concept of Reliability Centred Maintenance (RCM) which is the term used to describe a systematic approach to the evaluation, design and development of cost effective maintenance programmes for plant and equipment. The concept has been in existence for over 25 years originating in the civil aviation sector. This TECDOC supplements previous IAEA publications on the subject and seeks to reflect members experience in the application of the principles involved. The process focuses on the functionality of the plant and equipment and the critical failure mechanisms that could result in the loss of functionality. When employed effectively the process can result in the elimination of unnecessary maintenance activities and the identification and introduction of measures to address deficiencies in the maintenance programme. Overall the process can result in higher levels of reliability for the plant and equipment at reduced cost and demands on finite maintenance resources. The application of the process requires interaction between the operators and the maintenance practitioners which is often lacking in traditional maintenance programmes. The imposition of this discipline produces the added benefit of improved information flows between the key players in plant and equipment management with the result that maintenance activities and operational practices are better informed. This publication was produced within IAEA programme on nuclear power plants operating performance and life cycle management

  19. Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation.

    Science.gov (United States)

    Heller, Aaron S; Johnstone, Tom; Shackman, Alexander J; Light, Sharee N; Peterson, Michael J; Kolden, Gregory G; Kalin, Ned H; Davidson, Richard J

    2009-12-29

    Anhedonia, the loss of pleasure or interest in previously rewarding stimuli, is a core feature of major depression. While theorists have argued that anhedonia reflects a reduced capacity to experience pleasure, evidence is mixed as to whether anhedonia is caused by a reduction in hedonic capacity. An alternative explanation is that anhedonia is due to the inability to sustain positive affect across time. Using positive images, we used an emotion regulation task to test whether individuals with depression are unable to sustain activation in neural circuits underlying positive affect and reward. While up-regulating positive affect, depressed individuals failed to sustain nucleus accumbens activity over time compared with controls. This decreased capacity was related to individual differences in self-reported positive affect. Connectivity analyses further implicated the fronto-striatal network in anhedonia. These findings support the hypothesis that anhedonia in depressed patients reflects the inability to sustain engagement of structures involved in positive affect and reward.

  20. An effective manpower planning approach for maintenance ...

    African Journals Online (AJOL)

    The level of maintenance activities of a cocoa processing factory in Nigeria was studied. Data on critical machine parts involved in the maintenance work were collected and the different jobs carried out according to sections and nature of the activities were classified. The workloads for each type of maintenance activities ...

  1. An examination of maintenance activities in liquid metal reactor facilities: An analysis by the Centralized Reliability Data Organization (CREDO)

    Energy Technology Data Exchange (ETDEWEB)

    Haire, M J; Knee, H E; Manning, J J; Manneschmidt, J F; Setoguchi, K

    1987-01-01

    The Centralized Reliability Data Organization (CREDO) is the largest repository of liquid metal reactor (LMR) component reliability data in the world. It is jointly sponsored by the US Department of Energy (DOE) and the Power Reactor and Nuclear fuel Development Corporation (PNC) of Japan. The CREDO database contains information on a population of more than 21,000 components and approximately 1300 event records. Total experience is approaching 1.2 billion component operating hours. Although data gathering for CREDO concentrates on event (failure) information, the work reported here focuses on the maintenance information contained in CREDO and the development of maintenance critical items lists. That is, components are ranked in prioritized lists from worse to best performers from a maintenance standpoint.

  2. Maintenance, a global approach

    International Nuclear Information System (INIS)

    Calmejane, P.

    2001-01-01

    Maintenance is an important economic activity, it can represent up to 40% of operating costs in some fabrication units. The opening of energy markets to competition has led main operators to center their activities on their basis business and to sub-contract subsidiary activities. Subcontracting with strong engagements from the sub-contractor about results, time allowed and costs is now currently applied in nuclear industry. (A.C.)

  3. Remediation of language processing in aphasia: Improving activation and maintenance of linguistic representations in (verbal) short-term memory.

    Science.gov (United States)

    Kalinyak-Fliszar, Michelene; Kohen, Francine; Martin, Nadine

    2011-01-01

    BACKGROUND: Verbal short-term memory (STM) impairments are invariably present in aphasia. Word processing involves a minimal form of verbal STM, i.e., the time course over which semantic and phonological representations are activated and maintained until they are comprehended, produced, or repeated. Thus it is reasonable that impairments of word processing and verbal STM may co-occur. The co-occurrence of language and STM impairments in aphasia has motivated an active area of research that has revealed much about the relationship of these two systems and the effect of their impairment on language function and verbal learning (Freedman & Martin, 2001; Martin & Saffran, 1999; Trojano & Grossi, 1995). In keeping with this view a number of researchers have developed treatment protocols to improve verbal STM in order to improve language function (e.g., Koenig-Bruhin & Studer-Eichenberger, 2007). This account of aphasia predicts that treatment of a fundamental ability, such as STM, which supports language function, should lead to improvements that generalise to content and tasks beyond those implemented in treatment. AIMS: We investigated the efficacy of a treatment for language impairment that targets two language support processes: verbal short-term memory (STM) and executive processing, in the context of a language task (repetition). We hypothesised that treatment of these abilities would improve repetition abilities and performance on other language tasks that require STM. METHOD: A single-participant, multiple-baseline, multiple-probe design across behaviours was used with a participant with conduction aphasia. The treatment involved repetition of words and nonwords under three "interval" conditions, which varied the time between hearing and repeating the stimulus. Measures of treatment effects included acquisition, maintenance, and follow-up data, effect sizes, and pre- and post-treatment performance on a test battery that varies the STM and executive function

  4. Opportune maintenance and predictive maintenance decision support

    OpenAIRE

    Thomas , Edouard; Levrat , Eric; Iung , Benoît; Cocheteux , Pierre

    2009-01-01

    International audience; Conventional maintenance strategies on a single component are being phased out in favour of more predictive maintenance actions. These new kinds of actions are performed in order to control the global performances of the whole industrial system. They are anticipative in nature, which allows a maintenance expert to consider non-already-planned maintenance actions. Two questions naturally emerge: when to perform a predictive maintenance action; how a maintenance expert c...

  5. Nuclear maintenance and management system

    International Nuclear Information System (INIS)

    Yamaji, Yoshihiro; Abe, Norihiko

    2000-01-01

    The Mitsubishi Electric Co., Ltd. has developed to introduce various computer systems for desk-top business assistance in a power plant such as system isolation assisting system, operation parameter management system, and so on under aiming at business effectiveness since these ten and some years. Recently, by further elapsed years of the plants when required for further cost reduction and together with change of business environment represented by preparation of individual personal computer, further effectiveness, preparation of the business environment, and upgrading of maintenance in power plant business have been required. Among such background, she has carried out various proposals and developments on construction of a maintenance and management system integrated the business assistant know-hows and the plant know-hows both accumulated previously. They are composed of three main points on rationalization of business management and document management in the further effectiveness, preparation of business environment, TBM maintenance, introduction of CBM maintenance and introduction of maintenance assistance in upgrading of maintenance. Here was introduced on system concepts aiming at the further effectiveness of the nuclear power plant business, preparation of business environment, upgrading of maintenance and maintenance, and so on, at a background of environment around maintenance business in the nuclear power plants (cost-down, highly elapsed year of the plant, change of business environment). (G.K)

  6. UH-1 Helicopter Mechanic (MOS 67N20) Job Description Survey: Background, Training, and General Maintenance Activities.

    Science.gov (United States)

    Schulz, Russel E.; And Others

    The report, the first of two documents examining the relationship among job requirements, training, and manpower considerations for Army aviation maintenance Personnel, discusses the development of task data gathering techniques and procedures for incorporating this data into training programs for the UH-1 helicopter mechanic sPecialty (MOS…

  7. Maintenance of nuclear power plants

    International Nuclear Information System (INIS)

    1982-01-01

    This Guide covers the organizational and procedural aspects of maintenance but does not give detailed technical advice on the maintenance of particular plant items. It gives guidance on preventive and remedial measures necessary to ensure that all structures, systems and components important to safety are capable of performing as intended. The Guide covers the organizational and administrative requirements for establishing and implementing preventive maintenance schedules, repairing defective plant items, providing maintenance facilities and equipment, procuring stores and spare parts, selecting and training maintenance personnel, reviewing and controlling plant modifications arising from maintenance, and for generating, collecting and retaining maintenance records. Maintenance shall be subject to quality assurance in all aspects important to safety. Because quality assurance has been dealt with in detail in other Safety Guides, it is only included here in specific instances where emphasis is required. Maintenance is considered to include functional and performance testing of plant, surveillance and in-service inspection, where these are necessary either to support other maintenance activities or to ensure continuing capability of structures, systems and components important to safety to perform their intended functions

  8. Network maintenance

    CERN Multimedia

    GS Department

    2009-01-01

    A site-wide network maintenance operation has been scheduled for Saturday 28 February. Most of the network devices of the general purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites throughout the day. This upgrade will not affect the Computer Centre itself, Building 613, the Technical Network and the LHC experiments, dedicated networks at the pits. For further details of this intervention, please contact Netops by phone 74927 or e-mail mailto:Netops@cern.ch. IT/CS Group

  9. Network maintenance

    CERN Multimedia

    IT Department

    2009-01-01

    A site wide network maintenance has been scheduled for Saturday 28 February. Most of the network devices of the General Purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites along this day. This upgrade will not affect: the Computer centre itself, building 613, the Technical Network and the LHC experiments dedicated networks at the pits. Should you need more details on this intervention, please contact Netops by phone 74927 or email mailto:Netops@cern.ch. IT/CS Group

  10. Maintenance in sustainable manufacturing

    Directory of Open Access Journals (Sweden)

    Vladimir Stuchly

    2014-09-01

    Full Text Available Background: Sustainable development is about reaching a balance between economic, social, and environmental goals, as well as people's participation in the planning process in order to gain their input and support. For a company, sustainable development means adoption of such business strategy and actions that contribute to satisfying present needs of company and stakeholders, as well as simultaneous protection, maintenance and strengthening of human and environmental potential which will be needed in the future. This new approach forces manufacturing companies to change their previous management paradigms. New management paradigm should include new issues and develop innovative methods, practices and technologies striving for solving problem of shortages of resources, softening environment overload and enabling development of environment-friendly lifecycle of products. Hence, its realization requires updating existing production models as they are based on previously accepted paradigm of unlimited resources and unlimited regeneration capabilities. Maintenance plays a crucial role because of its impact on availability, reliability, quality and life cycle cost, thus it should be one of the main pillars of new business running model.  Material and methods: The following paper is a result of research on the literature and observation of practices undertaken by a company within maintenance area. Results and conclusions: The main message is that considering sustainable manufacturing requires considerable expanding range of analysis and focusing on supporting processes. Maintenance offers numerous opportunities of decreasing influence of business processes on natural environment and more efficient resources utilization. The goal of maintenance processes realizing sustainable development strategy is increased profitability of exploitation and optimization of total lifecycle cost without disturbing safety and environmental issues. 

  11. Effectiveness of physical activity interventions in achieving behaviour change maintenance in young and middle aged adults: A systematic review and meta-analysis.

    Science.gov (United States)

    Murray, Jennifer M; Brennan, Sarah F; French, David P; Patterson, Christopher C; Kee, Frank; Hunter, Ruth F

    2017-11-01

    Physical activity (PA) interventions are generally effective in supporting short-term behaviour change, but increases are not always maintained. This review examined the effectiveness of PA interventions for behaviour change maintenance in young and middle-aged adults, and investigated which Behaviour Change Techniques (BCTs) and other intervention features were associated with maintenance. Six databases (Medline, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, CINAHL, Web of Science) were systematically searched. Eligibility criteria were controlled trials investigating the effectiveness of PA interventions with adult (mean age 18-64 years) non-clinical populations using validated measures of PA behaviour at baseline and ≥six months' post-baseline. Results were pooled in meta-analyses using standardised mean differences (SMD) at five time intervals (6-9, 9-15, 15-21, 21-24, >24 months). Moderator analyses investigated the influence of sample and intervention characteristics on PA maintenance at 6-9 months. Sixty-two studies were included. PA interventions had a significant effect on behaviour maintenance 6-15 months post-baseline relative to controls. Interventions had a larger effect on maintenance at 6-9 months (SMD = 0.28; 95% CI: 0.20, 0.35; I 2  = 73%) compared to 9-15 months (SMD = 0.20; 95% CI: 0.13, 0.26; I 2  = 70%). Beyond 15 months, PA measurements were infrequent with little evidence supporting maintenance. Moderator analyses showed some BCTs and intervention settings moderated PA outcomes at 6-9 months. A multivariable meta-regression model showed interventions using the BCTs 'Prompt self-monitoring of behavioural outcome' (b = 1.46, p behaviour to 15 months. Greater consideration must be given to how future interventions encourage and measure maintenance of changes, and investigate broader psychological, social and environmental influences of PA behaviour. PROSPERO 2015:CRD42015025462. Copyright © 2017 Elsevier Ltd. All

  12. Optimum policies for a system with general imperfect maintenance

    International Nuclear Information System (INIS)

    Sheu, S.-H.; Lin, Y.-B.; Liao, G.-L.

    2006-01-01

    This study considers periodic preventive maintenance policies, which maximizes the availability of a repairable system with major repair at failure. Three types of preventive maintenance are performed, namely: imperfect preventive maintenance (IPM), perfect preventive maintenance (PPM) and failed preventive maintenance (FPM). The probability that preventive maintenance is perfect depends on the number of imperfect maintenances conducted since the previous renewal cycle, and the probability that preventive maintenance remains imperfect is not increasing. The optimum preventive maintenance time that maximizes availability is derived. Various special cases are considered. A numerical example is given

  13. Efficiency and relevancy of nuclear power plant maintenance

    International Nuclear Information System (INIS)

    Persson, Kenneth

    2001-12-01

    SKI has the intention to further develop the inspection activities to understand if maintenance is managed and developed efficiently. The task has been to identify criteria important to maintenance efficiency. The maintenance process has been reviewed to find steps in the process where maintenance efficiency preferably can be determined. The most important criteria for efficient maintenance, based on SKI regulations, are linked to the development of the maintenance program and to the follow up of already implemented maintenance programs. To achieve efficient maintenance there should be criteria and judgements at the development of the maintenance program to decide if structures, systems and components (SSK) fulfil their functions. If the deviations are maintenance related, a special maintenance program should be developed and implemented together with the regular maintenance program. To achieve efficient maintenance, the experience from already implemented maintenance, experience from other plant units and external experience should be methodically used at the development of the maintenance program

  14. Maintenance management for nuclear power plant 'Integrated valve maintenance'

    International Nuclear Information System (INIS)

    Gerner, P.; Zanner, G.

    2001-01-01

    The deregulation of Europe's power market does force many utilities, and especially nuclear power plant operators, to introduce extensive cost-cutting measures in order to be able to compete within this new environment. The optimization of plant outages provides considerable potential for raising plant availability but can also lower operating costs by reducing e.g. expenditure on maintenance. Siemens Nuclear Power GmbH, in cooperation with plant operators, is currently implementing new and improved service concepts which can have a major effect on the way in which maintenance will be performed in the future. Innovative service packages for maintenance in nuclear power plants are available which can be used to perform a time- and cost-effective maintenance. The concepts encompass optimization of the overall sequence from planning in advance to the individual measures including reduction of the scope of maintenance activities, identification of cost cutting potential and bundling of maintenance activities. The main features of these maintenance activities are illustrated here using the examples of outage planning and integrated valve maintenance. In nuclear power plants approx. 5000 valves are periodically preventively, condition-based or breakdown-based maintained. Because of this large number of valves to be maintained a high potential of improvements and cost reductions can be achieved by performing an optimized, cost-effective maintenance based on innovative methods and tools. Siemens Nuclear Power GmbH has developed and qualified such tools which allow to reduce service costs while maintaining high standards of safety and availability. By changing from preventive to predictive (condition-based) maintenance - the number of valves to be maintained may be reduced considerably. The predictive maintenance is based on the Siemens Nuclear Power GmbH diagnostic and evaluation method (ADAM). ADAM is used to monitor the operability of valves by analytical verification of

  15. Maintenance and environmental qualification

    International Nuclear Information System (INIS)

    Martin, R.S.; Austin, D.G.

    1995-01-01

    The design of today's nuclear generating plants involves many detailed design considerations. This includes comprehensive look at aging effects on plant components over their expected lifetimes. This is important to ensuring that the plant operates safely throughout its life. The effects of aging are required to be documented in detail in today's designs. This documentation provides assurance that safe operating conditions are maintained throughout the station life cycle. This requirement is analogous to the longer standing requirement to ensure pressure boundary integrity. The pressure boundary integrity requirement has existed in the industry since its inception. The subject of plant aging effects and the maintenance of functionality is known as Environmental Qualification (EQ). This paper will attempt to explain the wisdom of EQ and the potential for optimizing maintenance activities (to move from reactive to proactive activities), within the context of the overall maintenance program. It is the author's intent to encourage the active involvement of maintenance professionals in the effective implementation of the ongoing EQ program so that the benefits are maximized

  16. Dynamic contracting mechanism for pavement maintenance management

    NARCIS (Netherlands)

    Demirel, H.C.; De Ridder, H.A.J.

    2013-01-01

    Technological advances, financial possibilities and changes of demands have increasingly affected the pavement maintenance environment for outsourcing in recent years. This induces complexity in the contracting methods of pavement maintenance activities. Despite the fact that current contracting

  17. Prediction of attendance at fitness center: a comparison between the theory of planned behavior, the social cognitive theory, and the physical activity maintenance theory.

    Science.gov (United States)

    Jekauc, Darko; Völkle, Manuel; Wagner, Matthias O; Mess, Filip; Reiner, Miriam; Renner, Britta

    2015-01-01

    In the processes of physical activity (PA) maintenance specific predictors are effective, which differ from other stages of PA development. Recently, Physical Activity Maintenance Theory (PAMT) was specifically developed for prediction of PA maintenance. The aim of the present study was to evaluate the predictability of the future behavior by the PAMT and compare it with the Theory of Planned Behavior (TPB) and Social Cognitive Theory (SCT). Participation rate in a fitness center was observed for 101 college students (53 female) aged between 19 and 32 years (M = 23.6; SD = 2.9) over 20 weeks using a magnetic card. In order to predict the pattern of participation TPB, SCT and PAMT were used. A latent class zero-inflated Poisson growth curve analysis identified two participation patterns: regular attenders and intermittent exercisers. SCT showed the highest predictive power followed by PAMT and TPB. Impeding aspects as life stress and barriers were the strongest predictors suggesting that overcoming barriers might be an important aspect for working out on a regular basis. Self-efficacy, perceived behavioral control, and social support could also significantly differentiate between the participation patterns.

  18. Cocaine users with comorbid Cluster B personality disorders show dysfunctional brain activation and connectivity in the emotional regulation networks during negative emotion maintenance and reappraisal.

    Science.gov (United States)

    Albein-Urios, Natalia; Verdejo-Román, Juan; Soriano-Mas, Carles; Asensio, Samuel; Martínez-González, José Miguel; Verdejo-García, Antonio

    2013-12-01

    Cocaine dependence often co-occurs with Cluster B personality disorders. Since both disorders are characterized by emotion regulation deficits, we predicted that cocaine comorbid patients would exhibit dysfunctional patterns of brain activation and connectivity during reappraisal of negative emotions. We recruited 18 cocaine users with comorbid Cluster B personality disorders, 17 cocaine users without comorbidities and 21 controls to be scanned using functional magnetic resonance imaging (fMRI) during performance on a reappraisal task in which they had to maintain or suppress the emotions induced by negative affective stimuli. We followed region of interest (ROI) and whole-brain approaches to investigate brain activations and connectivity associated with negative emotion experience and reappraisal. Results showed that cocaine users with comorbid personality disorders had reduced activation of the subgenual anterior cingulate cortex during negative emotion maintenance and increased activation of the lateral orbitofrontal cortex and the amygdala during reappraisal. Amygdala activation correlated with impulsivity and antisocial beliefs in the comorbid group. Connectivity analyses showed that in the cocaine comorbid group the subgenual cingulate was less efficiently connected with the amygdala and the fusiform gyri and more efficiently connected with the anterior insula during maintenance, whereas during reappraisal the left orbitofrontal cortex was more efficiently connected with the amygdala and the right orbitofrontal cortex was less efficiently connected with the dorsal striatum. We conclude that cocaine users with comorbid Cluster B personality disorders have distinctive patterns of brain activation and connectivity during maintenance and reappraisal of negative emotions, which correlate with impulsivity and dysfunctional beliefs. Copyright © 2013 Elsevier B.V. and ECNP. All rights reserved.

  19. The role of the science council of Japan (SCJ) in peaceful uses of nuclear energy. Previous activities and expectation in future

    International Nuclear Information System (INIS)

    Kimura, Itsuro

    2005-01-01

    The Science Council of Japan (SCJ) was established as a special agency to deliberate and report on scientific matters, including research policies and grants. It also promotes the effective exchange of knowledge between researchers to achieve greater productivity in scientific research. It continuously strives to reform and innovate and leads to its 20th term based on latest amendments of the SCJ law, which will come into force in October 2005. This paper outlined its past activities on nuclear research and described expectation in its future activities to make a concrete statement on nuclear research based on comprehensive discussions from a different view of scientific research. (T. Tanaka)

  20. Optimizing preventive maintenance with maintenance templates

    International Nuclear Information System (INIS)

    Dozier, I.J.

    1996-01-01

    Rising operating costs has caused maintenance professionals to rethink their strategy for preventive maintenance (PM) programs. Maintenance Templates are pre-engineered PM task recommendations for a component type based on application of the component. Development of the maintenance template considers the dominant failure cause of the component and the type of preventive maintenance that can predict or prevent the failure from occurring. Maintenance template development also attempts to replace fixed frequency tasks with condition monitoring tasks such as vibration analysis or thermography. For those components that have fixed frequency PM intervals, consideration is given to the maintenance drivers such as criticality, environment and usage. This helps to maximize the PM frequency intervals and maximize the component availability. Maintenance Templates have been used at PECO Energy's Limerick Generating Station during the Reliability Centered Maintenance (RCM) Process to optimize their PM program. This paper describes the development and uses of the maintenance templates

  1. A Virtual Reality avatar interaction (VRai) platform to assess residual executive dysfunction in active military personnel with previous mild traumatic brain injury: proof of concept.

    Science.gov (United States)

    Robitaille, Nicolas; Jackson, Philip L; Hébert, Luc J; Mercier, Catherine; Bouyer, Laurent J; Fecteau, Shirley; Richards, Carol L; McFadyen, Bradford J

    2017-10-01

    This proof of concept study tested the ability of a dual task walking protocol using a recently developed avatar-based virtual reality (VR) platform to detect differences between military personnel post mild traumatic brain injury (mTBI) and healthy controls. The VR platform coordinated motion capture, an interaction and rendering system, and a projection system to present first (participant-controlled) and third person avatars within the context of a specific military patrol scene. A divided attention task was also added. A healthy control group was compared to a group with previous mTBI (both groups comprised of six military personnel) and a repeated measures ANOVA tested for differences between conditions and groups based on recognition errors, walking speed and fluidity and obstacle clearance. The VR platform was well tolerated by both groups. Walking fluidity was degraded for the control group within the more complex navigational dual tasking involving avatars, and appeared greatest in the dual tasking with the interacting avatar. This navigational behaviour was not seen in the mTBI group. The present findings show proof of concept for using avatars, particularly more interactive avatars, to expose differences in executive functioning when applying context-specific protocols (here for the military). Implications for rehabilitation Virtual reality provides a means to control context-specific factors for assessment and intervention. Adding human interaction and agency through avatars increases the ecologic nature of the virtual environment. Avatars in the present application of the Virtual Reality avatar interaction platform appear to provide a better ability to reveal differences between trained, military personal with and without mTBI.

  2. Metabolic activity by {sup 18}F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC

    Energy Technology Data Exchange (ETDEWEB)

    Kaira, Kyoichi; Altan, Bolag [Gunma University Graduate School of Medicine, Department of Oncology Clinical Development, Maebashi, Gunma (Japan); Higuchi, Tetsuya; Arisaka, Yukiko; Tokue, Azusa [Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Naruse, Ichiro [Hidaka Hospital, Department of Respiratory Medicine, Hidaka (Japan); Suda, Satoshi [Hidaka Hospital, Department of Radiology, Hidaka (Japan); Mogi, Akira; Shimizu, Kimihiro [Gunma University Graduate School of Medicine, Department of General Surgical Science, Maebashi, Gunma (Japan); Sunaga, Noriaki [Gunma University Hospital, Oncology Center, Maebashi, Gunma (Japan); Hisada, Takeshi [Gunma University Hospital, Department of Respiratory Medicine, Maebashi, Gunma (Japan); Kitano, Shigehisa [National Cancer Center Hospital, Department of Experimental Therapeutics, Tokyo (Japan); Obinata, Hideru; Asao, Takayuki [Gunma University Initiative for Advanced Research, Big Data Center for Integrative Analysis, Maebashi, Gunma (Japan); Yokobori, Takehiko [Gunma University Initiative for Advanced Research, Division of Integrated Oncology Research, Research Program for Omics-based Medical Science, Maebashi, Gunma (Japan); Mori, Keita [Clinical Research Support Center, Shizuoka Cancer Center, Suntou-gun (Japan); Nishiyama, Masahiko [Gunma University Graduate School of Medicine, Department of Molecular Pharmacology and Oncology, Maebashi, Gunma (Japan); Tsushima, Yoshihito [Gunma University Graduate School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Maebashi, Gunma (Japan); Gunma University Initiative for Advanced Research (GIAR), Research Program for Diagnostic and Molecular Imaging, Division of Integrated Oncology Research, Maebashi, Gunma (Japan)

    2018-01-15

    Nivolumab, an anti-programmed death-1 (PD-1) antibody, is administered in patients with previously treated non-small cell lung cancer. However, little is known about the established biomarker predicting the efficacy of nivolumab. Here, we conducted a preliminary study to investigate whether {sup 18}F-FDG-PET/CT could predict the therapeutic response of nivolumab at the early phase. Twenty-four patients were enrolled in this study. {sup 18}F-FDG-PET/CT was carried out before and 1 month after nivolumab therapy. SUV{sub max}, metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were calculated. Immunohistochemical analysis of PD-L1 expression and tumour-infiltrating lymphocytes was conducted. Among all patients, a partial metabolic response to nivolumab was observed in 29% on SUV{sub max}, 25% on MTV, and 33% on TLG, whereas seven (29%) patients achieved a partial response (PR) based on RECIST v1.1. The predictive probability of PR (100% vs. 29%, p = 0.021) and progressive disease (100% vs. 22.2%, p = 0.002) at 1 month after nivolumab initiation was significantly higher in {sup 18}F-FDG on PET/CT than in CT scans. Multivariate analysis confirmed that {sup 18}F-FDG uptake after administration of nivolumab was an independent prognostic factor. PD-L1 expression and nivolumab plasma concentration could not precisely predict the early therapeutic efficacy of nivolumab. Metabolic response by {sup 18}F-FDG was effective in predicting efficacy and survival at 1 month after nivolumab treatment. (orig.)

  3. Economies of scale and scope as an explanation of merger and output diversification activities in the health maintenance organization industry.

    Science.gov (United States)

    Given, R S

    1996-12-01

    This paper tests for the existence and magnitude of economies of scale and scope as possible explanations for the recent observed trends in increasing health maintenance organization (HMO) scale (through merger and acquisition) and scope (through greater participation in public enrollee markets) using firm level data from a sample of California HMOs for the time period 1986-1992. The results suggest that economies of scale provide a strong justification for mergers only in the case of relatively small HMOs (i.e. those with fewer than 115,000 enrollees), and economies of scope do not explain the increasing HMO enrollment of public enrollees.

  4. Using heuristic search for optimizing maintenance plans

    International Nuclear Information System (INIS)

    Mutanen, Teemu

    2012-01-01

    This work addresses the maintenance action selection process. Maintenance personnel need to evaluate maintenance actions and costs to keep the machines in working condition. Group of actions are evaluated together as maintenance plans. The maintenance plans as output provide information to the user about which actions to take if any and what future actions should be prepared for. The heuristic search method is implemented as part of general use toolbox for analysis of measurements from movable work machines. Impacts from machine's usage restrictions and maintenance activities are analysed. The results show that once put on a temporal perspective, the prioritized order of the actions is different and provide additional information to the user.

  5. Maintenance implementation plan for the Plutonium Finishing Plant. Revision 3

    International Nuclear Information System (INIS)

    Meldrom, C.A.

    1996-03-01

    This document outlines the Maintenance Implementation Plan (MIP) for the Plutonium Finishing Plant (PFP) located at the Hanford site at Richland, Washington. This MIP describes the PFP maintenance program relative to DOE order 4330.4B. The MIP defines the key actions needed to meet the guidelines of the Order to produce a cost-effective and efficient maintenance program. A previous report identified the presence of significant quantities of Pu-bearing materials within PFP that pose risks to workers. PFP's current mission is to develop, install and operate processes which will mitigate these risks. The PFP Maintenance strategy is to equip the facility with systems and equipment able to sustain scheduled PFP operations. The current operating run is scheduled to last seven years. Activities following the stabilization operation will involve an Environmental Impact Statement (EIS) to determine future plant activities. This strategy includes long-term maintenance of the facility for safe occupancy and material storage. The PFP maintenance staff used the graded approach to dictate the priorities of the improvement and upgrade actions identified in Chapter 2 of this document. The MIP documents PFP compliance to the DOE 4330.4B Order. Chapter 2 of the MIP follows the format of the Order in addressing the eighteen elements. As this revision is a total rewrite, no sidebars are included to highlight changes

  6. A mitogen-activated protein kinase Tmk3 participates in high osmolarity resistance, cell wall integrity maintenance and cellulase production regulation in Trichoderma reesei.

    Directory of Open Access Journals (Sweden)

    Mingyu Wang

    Full Text Available The mitogen-activated protein kinase (MAPK pathways are important signal transduction pathways conserved in essentially all eukaryotes, but haven't been subjected to functional studies in the most important cellulase-producing filamentous fungus Trichoderma reesei. Previous reports suggested the presence of three MAPKs in T. reesei: Tmk1, Tmk2, and Tmk3. By exploring the phenotypic features of T. reesei Δtmk3, we first showed elevated NaCl sensitivity and repressed transcription of genes involved in glycerol/trehalose biosynthesis under higher osmolarity, suggesting Tmk3 participates in high osmolarity resistance via derepression of genes involved in osmotic stabilizer biosynthesis. We also showed significant downregulation of genes encoding chitin synthases and a β-1,3-glucan synthase, decreased chitin content, 'budded' hyphal appearance typical to cell wall defective strains, and increased sensitivity to calcofluor white/Congo red in the tmk3 deficient strain, suggesting Tmk3 is involved in cell wall integrity maintenance in T. reesei. We further observed the decrease of cellulase transcription and production in T. reesei Δtmk3 during submerged cultivation, as well as the presence of MAPK phosphorylation sites on known transcription factors involved in cellulase regulation, suggesting Tmk3 is also involved in the regulation of cellulase production. Finally, the expression of cell wall integrity related genes, the expression of cellulase coding genes, cellulase production and biomass accumulation were compared between T. reesei Δtmk3 grown in solid state media and submerged media, showing a strong restoration effect in solid state media from defects resulted from tmk3 deletion. These results showed novel physiological processes that fungal Hog1-type MAPKs are involved in, and present the first experimental investigation of MAPK signaling pathways in T. reesei. Our observations on the restoration effect during solid state cultivation suggest

  7. Relationship Maintenance on Facebook: Development of a Measure, Relationship to General Maintenance, and Relationship Satisfaction

    Science.gov (United States)

    Dainton, Marianne

    2013-01-01

    Previous research indicates that the primary reason college students use Facebook is for relationship maintenance. The present study sought to determine the relationship between Facebook maintenance and general maintenance efforts in college student romantic relationships, as well as the impacts of such behaviors on the relationship. Survey data…

  8. Measurements for winter road maintenance

    OpenAIRE

    Riehm, Mats

    2012-01-01

    Winter road maintenance activities are crucial for maintaining the accessibility and traffic safety of the road network at northerly latitudes during winter. Common winter road maintenance activities include snow ploughing and the use of anti-icing agents (e.g. road salt, NaCl). Since the local weather is decisive in creating an increased risk of slippery conditions, understanding the link between local weather and conditions at the road surface is critically important. Sensors are commonly i...

  9. The Comparison of Neuro Behavioral Activity Mechanisms between Substance Abuse Sufferers under Maintenance Treatment and Non-Sufferers

    Directory of Open Access Journals (Sweden)

    H Kazemi

    2014-12-01

    Full Text Available Objective: The current study aimed at comparing preventive behavioral mechanisms behavioral tendencies, and the clash between drug users under maintenance treatmentandnon-users. Method: It was a causal-comparative study. All addicts of Esfahan city who had referred to one of the drug quitting centers constituted the study population. The selected sample consisted of 50drug users under maintenance treatment and 50non-users who were selected by convenience sampling. Gray- Wilson Personality Questionnaire was used for data collection purposes. Findings: The results showed that there was a significant difference between the two groups in terms of BAS and FFS scales while the difference between the two groups in terms of BIS scale was not reported to be significant. As well, there was a significant difference between the two groups in terms of approach, passive avoidance, fight, and silence. Conclusion: Investigating the neural/behavioral foundations within the range of substance abuse disorders indicates a difference between this group and those without the disorder, and it can further our understanding of the neural foundations of these disorders.

  10. How does the Augmented Reality Manual enhance cognitive activity while doing complex maintenance tasks?: Augmented Tutorial Overlaid Manual (ATOM)

    International Nuclear Information System (INIS)

    Yim, Ho Bin; Seong, Poong Hyun

    2008-01-01

    It has been more than a decade since the concept of Augmented Reality (AR) was introduced. Many related technologies, such as tracking and display, to animate this concept have improved to certain levels. AR is well suited for interaction with the cognitive vision system. In contrast to the virtual reality, AR applications enrich the perceived reality with additional visual information which ranges from text annotation and object highlighting to complex 3D objects. AR has been tested its potentiality in various forms of applications. For example, visitors wear Head Mount Display (HMD) to see virtual guides explaining artifacts in a museum or soldiers are informed geographical features about unfamiliar operation sites. Recently, researchers tried to use AR as a means of teaching or training apparatus; however, there are still some technical obstacles to put this fascinating technology into practice. In this study, we will use Cognitive Load Theory (CLT) to design a manual of pump maintenance and convert it to AR technology to propose a proto type of an on-line AR maintenance manual to prove its possibility as an interactive learning tool

  11. Remote maintenance development for ITER

    International Nuclear Information System (INIS)

    Tada, Eisuke; Shibanuma, Kiyoshi

    1997-01-01

    This paper both describes the overall design concept of the ITER remote maintenance system, which has been developed mainly for use with in-vessel components such as divertor and blanket, and outlines of the ITER R and D program, which has been established to develop remote handling equipment/tools and radiation hard components. In ITER, the reactor structures inside cryostat have to be maintained remotely because of activation due to DT operation. Therefore, remote-handling technology is fundamental, and the reactor-structure design must be made consistent with remote maintainability. The overall maintenance scenario and design concepts of the required remote handling equipment/tools have been developed according to their maintenance classification. Technologies are also being developed to verify the feasibility of the maintenance design and include fabrication and testing of a fullscale remote-handling equipment/tools for in-vessel maintenance. (author)

  12. Flight Crew Health Maintenance

    Science.gov (United States)

    Gullett, C. C.

    1970-01-01

    The health maintenance program for commercial flight crew personnel includes diet, weight control, and exercise to prevent heart disease development and disability grounding. The very high correlation between hypertension and overweight in cardiovascular diseases significantly influences the prognosis for a coronary prone individual and results in a high rejection rate of active military pilots applying for civilian jobs. In addition to physical fitness the major items stressed in pilot selection are: emotional maturity, glucose tolerance, and family health history.

  13. Development of preventive maintenance procedures and schedules

    International Nuclear Information System (INIS)

    Schlenker, H.V.; Hammel, J.

    1977-01-01

    An outline of the procedures and schedules developed for preventive maintenance in power stations within the Rheinisch-Westfaelisches Elektrizitaetswerk (RWE) is presented. After an introduction of maintenance in general the different kinds of preventive maintenance activities are described. This includes also the prerequisite identification systems. The aims of preventive maintenance and the measures are explained that have to be taken, if these aims are to be achieved. A number of examples from actual practice are cited. (orig.) [de

  14. Maintenance Business Plans.

    Science.gov (United States)

    Adams, Matt

    2002-01-01

    Discusses maintenance business plans, statements which provide accountability for facilities maintenance organizations' considerable budgets. Discusses the plan's components: statement of plan objectives, macro and detailed description of the facility assets, maintenance function descriptions, description of key performance indicators, milestone…

  15. Plant Maintenance. The Licensee's Viewpoint

    International Nuclear Information System (INIS)

    Ungi, T.

    1997-01-01

    Plant maintenance is a very complex process which requires considerable effort from both within the maintenance process and also many support activities. It is important that the plant maintenance policy is translated into a maintenance programme which will define all relevant aspects of the maintenance. An aspect of this maintenance programme will be a maintenance catalogue which will define the maintenance activities to be carried out and at what frequencies. This paper is aimed at discussing the maintenance philosophy and resulting maintenance catalogues currently adopted in Nuclear Electric Ltd, and in particular at Heysham 2 Power Station. It goes on to consider whether these maintenance catalogues contain the optimum maintenance and if not should they be changed. If change is required, the process by which this change will be brought about is also discussed. (author)

  16. Semi-pervasive interface on a virtual reality based training system for live line maintenance activities on energy distribution networks; Interface semi-pervasiva em um sistema de treinamento baseado em realidade virtual para atividades de manutencao em linha viva em redes de distribuicao de energia

    Energy Technology Data Exchange (ETDEWEB)

    Geus, Klaus de; Otto Filho, Eduardo; Goulart, Jomar Centeno [Companhia Paranaense de Energia (COPEL), Curitiba, PR (Brazil)], Emails: klaus@copel.com, eduardo.otto@copel.com, jomarcg@copel.com; Scheer, Sergio; Buriol, Tiago Martinuzzi; Rosendo, Matheus [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil)], Emails: scheer@ufpr.br, tiagoburiol@gmail.com, matheusrosendo@gmail.com; Felsky Filho, Carlos Eduardo [Instituto de Tecnologia para o Desenvolvimento (LACTEC), Curitiba, PR (Brazil)], Email: felsky@latec.org.br

    2010-04-15

    Techniques for live-line maintenance are those performed on power distribution networks without interrupting the flow of energy. This practice net avoids costs, but it is considered high-risk. Thus the effectiveness of previous training is very important and, therefore, constant efforts are made to find resources in order to improve the knowledge retention and quality of information provided. This paper discusses the development of a semi-immersive VR system for training of live-line maintenance activities. Aspects of the development software, its characteristics and functional model, in addition to the interactive devices are presented and the choices justified. The goal is to describe an unprecedented platform which uses devices the Nintendo Wii to provide a novel model of interaction and navigation in professional activities. This model is focused on some principles of ubiquitous computing and tangible interaction. (author)

  17. Remote handling maintenance of ITER

    International Nuclear Information System (INIS)

    Haange, R.

    1999-01-01

    The remote maintenance strategy and the associated component design of the International Thermonuclear Experimental Reactor (ITER) have reached a high degree of completeness, especially with respect to those components that are expected to require frequent or occasional remote maintenance. Large-scale test stands, to demonstrate the principle feasibility of the remote maintenance procedures and to develop the required equipment and tools, were operational at the end of the Engineering Design Activities (EDA) phase. The initial results are highly encouraging: major remote equipment deployment and component replacement operations have been successfully demonstrated. (author)

  18. On-line maintenance at Cofrentes NPP

    International Nuclear Information System (INIS)

    Roldan Vilches, J.; Moreno Matarranz, M. A.; Hermana Mendioroz, I.

    1998-01-01

    Cofrentes NPP has begun in 1997 activities related to At Power Preventive Maintenance over trains or systems which lead to a voluntary entry in a Limitative Condition of Operation (LCO) of the Technical Specifications. From others benefits, this program ha improved the risk management and the staff's knowledge over the functions and safety implications of the different systems, the better exploit of the resources, the co-ordination of the different organisations involved (Maintenance an Operation) and the reductions of works during shutdowns. Previous to each work, a feasibility study analyzes qualitative and quantitative (PSA), using the Risk Monitor, the implications on safety of all the tasks, assuring that the global safety of the Plant is always maintained. Tech. Spec. are analyzed in detail and also are analyzed situations of simultaneous unavailabilities of systems which could lead to a high risk situation. Two different risk controls are defined (punctual and accumulated) to assure that high risk situations will not be given. Finally, historical risk profile is analyzed to assure that the accumulated risk increase is not significant. Risk Monitor helps staff in the schedule and follow-up of the activities of On-Line Maintenance. Each one of the tasks are deeply planned and harshly analyzed and are carried out by high qualified workers. By the moment, this program is running with fully satisfaction on the Plant. (Author)

  19. Improving the TRIGA facility maintenance by predictive maintenance techniques

    International Nuclear Information System (INIS)

    Preda, M.; Sabau, C.; Barbalata, E.

    1997-01-01

    This work deals with the specific operation of equipment in radioactive environment or in conditions allowing radioactive contamination. The requirements of remote operation ensuring the operators' protection are presented. Also, the requirements of international standards issued by IAEA-Vienna are reviewed. The organizational withdraws of the maintenance activities, based on the standards and maintenance and repair directives still in force, are shown. It is emphasized the fact that this type of maintenance was adequate to a given level of technical development, characteristic for pre-computerized industry, but, at present, it is obsolete and uneconomic both in utilization and maintenance. Such a system constitutes already a burden hindering the efforts of maximizing the availability, maintenance, prolongation the service life of equipment and utilities, finally, of increasing the efficiency of complex installations. Moreover, the predictive maintenance techniques are strongly requested by the character of radioactive installations precluding the direct access in given zones (a potential risk of irradiation or radioactive contamination) of installations during operation. The results obtained by applying the predictive maintenance techniques in the operation of the double circuit irradiation loop, used in the TRIGA reactors, are presented

  20. Look out for strangers! Sustained neural activity during visual working memory maintenance of other-race faces is modulated by implicit racial prejudice

    Science.gov (United States)

    Sessa, Paola; Tomelleri, Silvia; Luria, Roy; Castelli, Luigi; Reynolds, Michael

    2012-01-01

    We tested the ability of white participants to encode and retain over a brief period of time information about the identity of white and black people, using faces as stimuli in a standard change detection task and tracking neural activity using electroencephalography. Neural responses recorded over the posterior parietal cortex reflecting visual working memory activity increased in amplitude as a function of the number of faces that had to be maintained in memory. Critically, these memory-related neural responses varied as a function of participants’ implicit racial prejudice toward black people. High-prejudiced participants encoded black people faces with a lower degree of precision compared to low-prejudiced participants, suggesting that the class of mental operations affected by implicit racial prejudice includes basic cognitive mechanisms underpinning the encoding and maintenance of faces’ visual representations in visual working memory. PMID:21768206

  1. Look out for strangers! Sustained neural activity during visual working memory maintenance of other-race faces is modulated by implicit racial prejudice.

    Science.gov (United States)

    Sessa, Paola; Tomelleri, Silvia; Luria, Roy; Castelli, Luigi; Reynolds, Michael; Dell'Acqua, Roberto

    2012-03-01

    We tested the ability of white participants to encode and retain over a brief period of time information about the identity of white and black people, using faces as stimuli in a standard change detection task and tracking neural activity using electroencephalography. Neural responses recorded over the posterior parietal cortex reflecting visual working memory activity increased in amplitude as a function of the number of faces that had to be maintained in memory. Critically, these memory-related neural responses varied as a function of participants' implicit racial prejudice toward black people. High-prejudiced participants encoded black people faces with a lower degree of precision compared to low-prejudiced participants, suggesting that the class of mental operations affected by implicit racial prejudice includes basic cognitive mechanisms underpinning the encoding and maintenance of faces' visual representations in visual working memory. © The Author (2011). Published by Oxford University Press.

  2. Building Maintenance Management System for Heritage Museum

    Directory of Open Access Journals (Sweden)

    Md Azree Othuman Mydin

    2012-09-01

    Full Text Available An investment in the building maintenance aspect is massive throughout the world. In most of the countries, it signifies approximately 50% of the entire revenue of the construction industry. The value of buildings depends on the eminence of the maintenance invested in them. Maintenance management engages obtaining utmost advantage from the investment made on the maintenance activities. At the moment, maintenance in buildings in Malaysia is on the increase in spite of size, category, location, and ownership. This study focuses on Building Maintenance Management System for Heritage Museum, which consists of two case studies in Penang State Museum and Art Gallery, Malaysia and Museum of Perak, Malaysia. The aim of this study is to propose methods to improve the maintenance management system for heritage museum. From the results, the common problem occurs during the implementation for the maintenance of each building is the budget for the maintenance and worker’s skill. The department of each museum must have their own maintenance unit to keep an eye on the maintenance activities for their buildings in order to improve the maintenance management system in their building.

  3. Ergonomics in designing process: dialogue between designers, executors and users in the maintenance activity of radars in an oil refinery.

    Science.gov (United States)

    Menegon, Fabrício Augusto; Rodrigues, Daniela da Silva; Fontes, Andréa Regina Martins; Menegon, Nilton Luiz

    2012-01-01

    This paper aims to discuss the role of ergonomics in design process using the dialogue developed by designers, implementers and users in an oil refinery. It was possible to identify the need of minimizing the postural constraints, risk of accidents, mechanical shocks and to enlarge safety perception in the access and permanency of the users at the workspace. It has been determined and validated by workers and managers to implement different deadlines depending on programming, viability and execution time for the improvements proposed. In a long-term: it was proposed the substitution of the ladders with time planning according to the maintenance program of the tanks; in a short-time: it was suggested the expansion of the existing platforms, implementation of a walkway connection provided with guardrails between the upper access of the side ladder and the repositioning of radar set and aerial aiming at the usage by workers at the workstation of the new platform. It was also elaborated eight typologies of intervention, according to the request, type of tank, material stored, and its setting place. The design process arises from ergonomics workplace analysis that presents concepts for solutions which was a mediator tool to be settled between users and implementers.

  4. Susquehanna SES maintenance supervisor training and certification

    International Nuclear Information System (INIS)

    Deckman, M.

    1991-01-01

    Susquehanna's program targets all Supervisors, Supervisor Candidates, and Temporary Supervisors that are responsible for in-plant maintenance or maintenance support activities, including: mechanical maintenance; electrical maintenance; maintenance support (labor support, radwaste, etc.); mobile construction support (mechanical and electrical); chemistry; health physics; maintenance planning; and instrument and controls. The program integrates the three major areas of direct Supervisory responsibilities: (1) Leadership and Management - Skills that require interpersonal activities that are typically humanistic and subjective; such as coaching, motivating, communications, etc. (2) Technical and Administrative - Knowledge that is directly related to the job of Supervising from the production, regulatory, accountability perspective. These topics are very objective and include training on topics such as workpackages, plant chemistry parameters, radiological concerns, etc. (3) Technical Skills - Ensure each Supervisor is technically competent in the plant systems, components, or equipment he/she is tasked with maintaining or overseeing. Typical skills found in this area are, circuit breaker maintenance, primary system sampling, or overhauling pumps

  5. Reducing maintenance costs

    International Nuclear Information System (INIS)

    Zaiss, W.; Reuschle, K.; Baier, B.

    2002-01-01

    The increasingly more expensive maintenance measures, cuts in the cost budget, and the loss of know-how on the part of vendors all require a change of policy with respect to maintenance concepts of the part of operators. This also applies to the existing valve concepts, the drives included. Under these aspects, the current drive, which is self-actuated and actuated by outside media, for a parallel-plate valve of a nomial width of 700 was reconsidered. The effort served to reduce maintenance costs and, at the same time, simplify the drive concept as well as cut back on the number of in-service inspections. Moreover, the number of active components were to be minimized and installation conditions in the plant were to be improved. When the boundary conditions to be observed with respect to process technology had been laid down, the competent technical department developed a concept of modification of the drive. A major constituent part was the demonstration of the functioning capability of the new drive under accident conditions. It was achieved mainly by an analytical approach. In the resultant drive concept, the same control valves are employed to actuate a driving cylinder by means of self-actuation or by an outside medium as a function of pressure. (orig.) [de

  6. A Situational Maintenance Model

    DEFF Research Database (Denmark)

    Luxhoj, James T.; Thorsteinsson, Uffe; Riis, Jens Ove

    1997-01-01

    An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance.......An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance....

  7. Consolidating Air Force Maintenance Occupational Specialties

    Science.gov (United States)

    2016-01-01

    these questions, the impact of AFS consolidation on active duty KC-135 maintenance personnel at MacDill, McConnell , and Fairchild Air Force Bases...readiness? The analysis presented here considers the impact of AFS consolidation on active-duty KC- 135 maintenance personnel at MacDill, McConnell ... Concept for Air Force Maintenance: Conclusions from Analysis of C-130, F-16, and KC-135 Fleets, Santa Monica, Calif.: RAND Corporation, MG-919-AF, 2010

  8. The influence of condition-based maintenance on workforce planning and maintenance scheduling

    NARCIS (Netherlands)

    Koochaki, Javid; Bokhorst, Jos A. C.; Wortmann, Hans; Klingenberg, Warse

    2013-01-01

    Condition-based maintenance (CBM) is generally considered an attractive maintenance policy for a single component: it uses the operating condition of the component to predict a failure event and therefore tries to avoid any unplanned downtime and unnecessary maintenance activities. However,

  9. The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    Deng Liting

    2012-09-01

    Full Text Available Abstract Background Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB2 agonist, produces antinociception without producing central nervous system (CNS-associated side effects. The present study was conducted to examine the antinociceptive effect of AM1710 in rodent models of neuropathic pain evoked by diverse chemotherapeutic agents (cisplatin and paclitaxel. A secondary objective was to investigate the potential contribution of alpha-chemokine receptor (CXCR4 signaling to both chemotherapy-induced neuropathy and CB2 agonist efficacy. Results AM1710 (0.1, 1 or 5 mg/kg i.p. suppressed the maintenance of mechanical and cold allodynia in the cisplatin and paclitaxel models. Anti-allodynic effects of AM1710 were blocked by the CB2 antagonist AM630 (3 mg/kg i.p., but not the CB1 antagonist AM251 (3 mg/kg i.p., consistent with a CB2-mediated effect. By contrast, blockade of CXCR4 signaling with its receptor antagonist AMD3100 (10 mg/kg i.p. failed to attenuate mechanical or cold hypersensitivity induced by either cisplatin or paclitaxel. Moreover, blockade of CXCR4 signaling failed to alter the anti-allodynic effects of AM1710 in the paclitaxel model, further suggesting distinct mechanisms of action. Conclusions Our results indicate that activation of cannabinoid CB2 receptors by AM1710 suppresses both mechanical and cold allodynia in two distinct models of chemotherapy-induced neuropathic pain. By contrast, CXCR4 signaling does not contribute to the maintenance of chemotherapy-induced established neuropathy or efficacy of AM1710. Our studies suggest that CB2 receptors represent a promising therapeutic target for the treatment of toxic neuropathies produced by cisplatin and paclitaxel chemotherapeutic agents.

  10. Organisational challenges of maintenance work at NPPs

    International Nuclear Information System (INIS)

    Reiman, T.; Oedewald, P.

    2004-01-01

    The proper working of the machinery is critical to NPP safety and productivity. Because maintenance routines and plant modifications are the activities that intervene most with the machinery, they are also the dominant sources of faults. Most of the human factor studies have relied on this fact. Due to the diversity, the temporal and spatial separation of the maintenance tasks, and the numerous competence requirements, focusing on a single task, special situation or a single psychological problem can only partially explain the requirements of maintenance work and the organisational challenges of effective maintenance. We have applied a cultural approach to maintenance work. Our aim has been to model the maintenance task and its psychological requirements and to characterise the features of organisational cultures in three NPP maintenance units. Results imply similarities and differences in the cultures and in the emphasis on the maintenance task. Maintenance activities have been under various restructuring initiatives. These changes have been experienced as stressful among the personnel. The effect of changes on the reliability of maintenance should be considered. A challenge for maintenance is to be able to build organisational structures and practices that would facilitate the fulfilment of the psychological work characteristics. (orig.)

  11. Data sharing report characterization of population 7: Personal protective equipment, dry active waste, and miscellaneous debris, surveillance and maintenance project Oak Ridge National Laboratory Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Harpenau, Evan M. [Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)

    2013-10-10

    The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management (EM-OR) requested that Oak Ridge Associated Universities (ORAU), working under the Oak Ridge Institute for Science and Education (ORISE) contract, provide technical and independent waste management planning support under the American Recovery and Reinvestment Act (ARRA). Specifically, DOE EM-OR requested that ORAU plan and implement a sampling and analysis campaign targeting certain URS|CH2M Oak Ridge, LLC (UCOR) surveillance and maintenance (S&M) process inventory waste. Eight populations of historical and reoccurring S&M waste at the Oak Ridge National Laboratory (ORNL) have been identified in the Waste Handling Plan for Surveillance and Maintenance Activities at the Oak Ridge National Laboratory, DOE/OR/01-2565&D2 (WHP) (DOE 2012) for evaluation and processing to determine a final pathway for disposal. Population 7 (POP 7) consists of 56 containers of aged, low-level and potentially mixed S&M waste that has been staged in various locations around ORNL. Several of these POP 7 containers primarily contain personal protective equipment (PPE) and dry active waste (DAW), but may contain other miscellaneous debris. This data sharing report addresses the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) specified waste in a 13-container subpopulation (including eight steel boxes, three 55-gal drums, one sealand, and one intermodal) that lacked sufficient characterization data for possible disposal at the Environmental Management Waste Management Facility (EMWMF) using the approved Waste Lot (WL) 108.1 profile.

  12. Characterization of Active Anthocyanin Degradation in the Petals of Rosa chinensis and Brunfelsia calycina Reveals the Effect of Gallated Catechins on Pigment Maintenance.

    Science.gov (United States)

    Luo, Honghui; Deng, Shuangfan; Fu, Wei; Zhang, Xin; Zhang, Xuelian; Zhang, Zhaoqi; Pang, Xuequn

    2017-03-25

    Anthocyanin degradation decreases ornamental or nutritional values of horticultural products. To investigate factors that may influence colour change in flower development, anthocyanin degradation was compared between the flowers of Brunfelsia calycina and Rosa chinensis , which show rapid and slow degradation, respectively. In-gel activity assays, high performance liquid chromatography (HPLC) analysis of tannins, enzyme kinetics measurement and immune-detection of anthocyanin degradation related-perioxidases (PODs) were carried out for the comparison. Rose petals possessed significantly lower anthocyanin degradation-related POD activities than Brunfelsia petals, which may be related to the high tannin contents. Epicatechin gallate (ECG) and gallocatechin gallate (GCG) were detected in rose as 161.3 ± 12.34 and 273.56 ± 41.23 μg/g FW (Fresh Weight) respectively, while not detected in Brunfelsia . ECG and GCG inhibited the activities of the Brunfelsia POD with half maximal inhibitory concentrations (IC50s) as 21.5 and 29.7 μM respectively, and increased the colour intensities of the anthocyanins. Catechin and epicatechin did not inhibit the POD activity, while serving as POD substrates, with K m (the Michaelis constant) as 0.48 and 1.23 mM. Similar protein levels of the anthocyanin degradation-related 40-kDa PODs were detected in Brunfelsia and rose. In summary, high amount of tannins, particularly ECG and GCG, in red rose petals may inhibit the degradation-related enzymes, leading to the maintenance of anthocyanins in vivo.

  13. INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby...... including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor...... dormancy and treating cancer in a subject....

  14. Lean thinking for a maintenance process

    Directory of Open Access Journals (Sweden)

    Sherif Mostafa

    2015-01-01

    Full Text Available The maintenance process shares significant operating costs in an organisation. Lean thinking can be incorporated into maintenance activities through applying its principles and practices/tools. Lean maintenance (LM is a prerequisite for lean manufacturing systems. This research proposes a new structure for LM process based on a systematic literature review of a significant number of related articles that were published on LM. The process structure is designed based on the five lean principles to guide and support organisations to pursue maintenance excellence. This study establishes a scheme for LM tools that are structured into 2 level 4 bundles and 26 lean practices/tools and develops a House of Waste (HoW to demonstrate the association between maintenance wastes and the LM tools. With a successful accomplishment of the proposed scheme, the performance of a maintenance department can create more improvement opportunities over time to reach the maintenance excellence status.

  15. Development of blanket remote maintenance system

    Energy Technology Data Exchange (ETDEWEB)

    Kakudate, Satoshi; Nakahira, Masataka; Oka, Kiyoshi; Taguchi, Kou [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-04-01

    ITER in-vessel components such as blankets are scheduled maintenance components, including complete shield blanket replacement for breeding blankets. In-vessel components are activated by 14 MeV neutrons, so blanket maintenance requires remote handling equipment and tools able to handle heavy payloads of about 4 tons within a positioning accuracy of 2 mm under intense gamma radiation. To facilitate remote maintenance, blankets are segmented into 730 modules and rail-mounted vehicle remote maintenance was developed. According to the ITER R and D program, critical technology related to blanket maintenance was developed extensively through joint efforts of the Japan, EU, and U.S. home teams. This paper summarizes current blanket maintenance technology conducted by the Japan Home Team, including development of full-scale remote handling equipment and tools for blanket maintenance. (author)

  16. Development of divertor remote maintenance system

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Nobukazu; Oka, Kiyoshi; Akou, Kentaro; Takiguchi, Yuji [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-04-01

    The ITER divertor is categorized as a scheduled maintenance component because of extreme heat and particle loads it is exposed to by plasma. It is also highly activated by 14 MeV neutrons. Reliable remote handling equipment and tools are required for divertor maintenance under intense gamma radiation. To facilitate remote maintenance, the divertor is segmented into 60 cassettes, and each cassette weighing about 25 tons and maintained and replaced through four maintenance ports each 90 degrees. Divertor cassettes must be transported toroidally and radially for replacement through maintenance ports. Remote handling involving cassette movers and carriers for toroidal and radial transport has been developed. Under the ITER R and D program, technology critical to divertor cassette maintenance is being developed jointly by Japan, E.U., and U.S. home teams. This paper summarizes divertor remote maintenance design and the status of technology development by the Japan Home Team. (author)

  17. Development of divertor remote maintenance system

    International Nuclear Information System (INIS)

    Takeda, Nobukazu; Oka, Kiyoshi; Akou, Kentaro; Takiguchi, Yuji

    1998-01-01

    The ITER divertor is categorized as a scheduled maintenance component because of extreme heat and particle loads it is exposed to by plasma. It is also highly activated by 14 MeV neutrons. Reliable remote handling equipment and tools are required for divertor maintenance under intense gamma radiation. To facilitate remote maintenance, the divertor is segmented into 60 cassettes, and each cassette weighing about 25 tons and maintained and replaced through four maintenance ports each 90 degrees. Divertor cassettes must be transported toroidally and radially for replacement through maintenance ports. Remote handling involving cassette movers and carriers for toroidal and radial transport has been developed. Under the ITER R and D program, technology critical to divertor cassette maintenance is being developed jointly by Japan, E.U., and U.S. home teams. This paper summarizes divertor remote maintenance design and the status of technology development by the Japan Home Team. (author)

  18. A Strategy for Maintenance of the Long-Term Performance Assessment of Immobilized Low-Activity Waste Glass

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, Joseph V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Freedman, Vicky L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-28

    Approximately 50 million gallons of high-level radioactive mixed waste has accumulated in 177 buried single- and double-shell tanks at the Hanford Site in southeastern Washington State as a result of the past production of nuclear materials, primarily for defense uses. The United States Department of Energy (DOE) is proceeding with plans to permanently dispose of this waste. Plans call for separating the tank waste into high-level waste (HLW) and low-activity waste (LAW) fractions, which will be vitrified at the Hanford Waste Treatment and Immobilization Plant (WTP). Principal radionuclides of concern in LAW are 99Tc, 129I, and U, while non-radioactive contaminants of concern are Cr and nitrate/nitrite. HLW glass will be sent off-site to an undetermined federal site for deep geological disposal while the much larger volume of immobilized low-activity waste will be placed in the on-site, near-surface Integrated Disposal Facility (IDF).

  19. Data Sharing Report for the Quantification of Removable Activity in Various Surveillance and Maintenance Facilities at the Oak Ridge National Laboratory Oak Ridge TN

    Energy Technology Data Exchange (ETDEWEB)

    King, David A. [Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)

    2013-12-12

    The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management (OR-EM) requested that Oak Ridge Associated Universities (ORAU), working under the Oak Ridge Institute for Science and Education (ORISE) contract, provide technical and independent waste management planning support using American Recovery and Reinvestment Act (ARRA) funds. Specifically, DOE OR-EM requested that ORAU plan and implement a sampling and analysis campaign targeting potential removable radiological contamination that may be transferrable to future personal protective equipment (PPE) and contamination control materials—collectively referred to as PPE throughout the remainder of this report—used in certain URS|CH2M Oak Ridge, LLC (UCOR) Surveillance and Maintenance (S&M) Project facilities at the Oak Ridge National Laboratory (ORNL). Routine surveys in Bldgs. 3001, 3005, 3010, 3028, 3029, 3038, 3042, 3517, 4507, and 7500 continuously generate PPE. The waste is comprised of Tyvek coveralls, gloves, booties, Herculite, and other materials used to prevent worker exposure or the spread of contamination during routine maintenance and monitoring activities. This report describes the effort to collect and quantify removable activity that may be used by the ORNL S&M Project team to develop radiation instrumentation “screening criteria.” Material potentially containing removable activity was collected on smears, including both masselin large-area wipes (LAWs) and standard paper smears, and analyzed for site-related constituents (SRCs) in an analytical laboratory. The screening criteria, if approved, may be used to expedite waste disposition of relatively clean PPE. The ultimate objectives of this effort were to: 1) determine whether screening criteria can be developed for these facilities, and 2) provide process knowledge information for future site planners. The screening criteria, if calculated, must be formally approved by Federal Facility Agreement parties prior to use for

  20. Pacific Northwest Laboratory Maintenance Implementation plan

    International Nuclear Information System (INIS)

    Bright, J.D.

    1992-06-01

    This Maintenance Implementation plan has been developed for Pacific Northwest Laboratory's (PNL) Nuclear Facilities: 306W, 324, 325, 327 and 329NMF. It is based on a graded approach, self-assessment of the existing maintenance program(s) per the requirements specified by US Department of Energy (DOE) Order 4330.4A, Chapter II, Change number-sign 3. The results of this assessment were evaluated to determine needed improvements in PNL Craft Services' current maintenance program. The objective of this implementation plan is to provide baseline information for compliance to the DOE 4330.4A, and for needed improvements. The prime consideration in applying a graded approach to the Order has been to maintain safe and reliable operations, environmental compliance, safeguards and security, programmatic mission, facility preservation, and/or other facility-specific requirements. Using the results of the self-assessment, PNL has selected nine of the 18 elements of the Maintenance Program defined by DOE Order 4330.4A for improvement. The elements selected for improvement are Training and Qualification of Maintenance Personnel; Maintenance Procedures; Planning, Scheduling, and Coordination of Maintenance; Control of Maintenance Activities; Post-Maintenance Testing; Facility Condition Inspection; Management Involvement; Maintenance History; and Additional Maintenance Requirements. Based upon graded approach and current funding, those elements considered most important have been selected as goals for earliest compliance. Commitment dates for these elements have been established for compliance. The remaining elements of noncompliance will be targeted for implementation during later budget periods

  1. Electric motor predictive and preventive maintenance guide

    International Nuclear Information System (INIS)

    Oliver, J.A.

    1992-07-01

    Electric motor performance is vital to the reliable and efficient operation of power plants. The failure of one or more critical motors could cause lost capacity and excessive repair and maintenance cost. However, existing maintenance recommendations proposed by vendors for electric motors have sometimes encouraged many overly conservative maintenance practices. These practices have lead to excessive maintenance activities and costs which have provided no extra margin of operability. EPRI has sponsored RP2814-35 to develop a guide which provides power plants with information and guidance for establishing an effective maintenance program which will aid in preventing unexpected motor failures and assist in planning motor maintenance efforts. The guide includes a technical description which summarizes technical data relative to the four basic types of motors and their components in general use in power plants. The significant causes of motor failures are investigated and described in detail and methods to optimize service life and minimize maintenance cost through appropriate preventive maintenance and conditioning program are presented. This guide provides a foundation for an effective electric motor maintenance program and simplifies the selection of predictive and preventive maintenance tasks. Its use will enable maintenance personnel in nuclear and fossil plants to plan motor repairs during scheduled outages and avoid costly unexpected failures

  2. Pacific Northwest Laboratory Maintenance Implementation plan

    Energy Technology Data Exchange (ETDEWEB)

    Bright, J.D.

    1992-06-01

    This Maintenance Implementation plan has been developed for Pacific Northwest Laboratory's (PNL) Nuclear Facilities: 306W, 324, 325, 327 and 329NMF. It is based on a graded approach, self-assessment of the existing maintenance program(s) per the requirements specified by US Department of Energy (DOE) Order 4330.4A, Chapter II, Change {number sign}3. The results of this assessment were evaluated to determine needed improvements in PNL Craft Services' current maintenance program. The objective of this implementation plan is to provide baseline information for compliance to the DOE 4330.4A, and for needed improvements. The prime consideration in applying a graded approach to the Order has been to maintain safe and reliable operations, environmental compliance, safeguards and security, programmatic mission, facility preservation, and/or other facility-specific requirements. Using the results of the self-assessment, PNL has selected nine of the 18 elements of the Maintenance Program defined by DOE Order 4330.4A for improvement. The elements selected for improvement are Training and Qualification of Maintenance Personnel; Maintenance Procedures; Planning, Scheduling, and Coordination of Maintenance; Control of Maintenance Activities; Post-Maintenance Testing; Facility Condition Inspection; Management Involvement; Maintenance History; and Additional Maintenance Requirements. Based upon graded approach and current funding, those elements considered most important have been selected as goals for earliest compliance. Commitment dates for these elements have been established for compliance. The remaining elements of noncompliance will be targeted for implementation during later budget periods.

  3. Pacific Northwest Laboratory Maintenance Implementation plan

    Energy Technology Data Exchange (ETDEWEB)

    Bright, J.D.

    1992-06-01

    This Maintenance Implementation plan has been developed for Pacific Northwest Laboratory`s (PNL) Nuclear Facilities: 306W, 324, 325, 327 and 329NMF. It is based on a graded approach, self-assessment of the existing maintenance program(s) per the requirements specified by US Department of Energy (DOE) Order 4330.4A, Chapter II, Change {number_sign}3. The results of this assessment were evaluated to determine needed improvements in PNL Craft Services` current maintenance program. The objective of this implementation plan is to provide baseline information for compliance to the DOE 4330.4A, and for needed improvements. The prime consideration in applying a graded approach to the Order has been to maintain safe and reliable operations, environmental compliance, safeguards and security, programmatic mission, facility preservation, and/or other facility-specific requirements. Using the results of the self-assessment, PNL has selected nine of the 18 elements of the Maintenance Program defined by DOE Order 4330.4A for improvement. The elements selected for improvement are Training and Qualification of Maintenance Personnel; Maintenance Procedures; Planning, Scheduling, and Coordination of Maintenance; Control of Maintenance Activities; Post-Maintenance Testing; Facility Condition Inspection; Management Involvement; Maintenance History; and Additional Maintenance Requirements. Based upon graded approach and current funding, those elements considered most important have been selected as goals for earliest compliance. Commitment dates for these elements have been established for compliance. The remaining elements of noncompliance will be targeted for implementation during later budget periods.

  4. Effectiveness and cost-effectiveness of a physical activity loyalty scheme for behaviour change maintenance: a cluster randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Ruth F. Hunter

    2016-07-01

    Full Text Available Abstract Background Increasing physical activity in the workplace can provide employee physical and mental health benefits, and employer economic benefits through reduced absenteeism and increased productivity. The workplace is an opportune setting to encourage habitual activity. However, there is limited evidence on effective behaviour change interventions that lead to maintained physical activity. This study aims to address this gap and help build the necessary evidence base for effective, and cost-effective, workplace interventions. Methods/design This cluster randomised control trial will recruit 776 office-based employees from public sector organisations in Belfast and Lisburn city centres, Northern Ireland. Participants will be randomly allocated by cluster to either the Intervention Group or Control Group (waiting list control. The 6-month intervention consists of rewards (retail vouchers, based on similar principles to high street loyalty cards, feedback and other evidence-based behaviour change techniques. Sensors situated in the vicinity of participating workplaces will promote and monitor minutes of physical activity undertaken by participants. Both groups will complete all outcome measures. The primary outcome is steps per day recorded using a pedometer (Yamax Digiwalker CW-701 for 7 consecutive days at baseline, 6, 12 and 18 months. Secondary outcomes include health, mental wellbeing, quality of life, work absenteeism and presenteeism, and use of healthcare resources. Process measures will assess intervention “dose”, website usage, and intervention fidelity. An economic evaluation will be conducted from the National Health Service, employer and retailer perspective using both a cost-utility and cost-effectiveness framework. The inclusion of a discrete choice experiment will further generate values for a cost-benefit analysis. Participant focus groups will explore who the intervention worked for and why, and interviews with

  5. Cows are not mice: the role of cyclic AMP, phosphodiesterases, and adenosine monophosphate-activated protein kinase in the maintenance of meiotic arrest in bovine oocytes.

    Science.gov (United States)

    Bilodeau-Goeseels, Sylvie

    2011-01-01

    Meiotic maturation in mammalian oocytes is initiated during fetal development, and is then arrested at the dictyate stage - possibly for several years. Oocyte meiosis resumes in preovulatory follicles in response to the lutenizing hormone (LH) surge or spontaneously when competent oocytes are removed from follicles and cultured. The mechanisms involved in meiotic arrest and resumption in bovine oocytes are not fully understood, and several studies point to important differences between oocytes from rodent and livestock species. This paper reviews earlier and contemporary studies on the effects of cAMP-elevating agents and phosphodiesterase (PDE) enzyme inhibitors on the maintenance of meiotic arrest in bovine oocytes in vitro. Contrary to results obtained with mouse oocytes, bovine oocyte meiosis is inhibited by activators of the energy sensor adenosine monophosphate-activated protein kinase (AMPK, mammalian gene PRKA), which is activated by AMP, the degradation product of cAMP. It is not clear whether or not the effects were due to AMPK activation, and they may depend on culture conditions. Evidence suggests that other signaling pathways (for example, the cGMP/nitric oxide pathway) are involved in bovine oocyte meiotic arrest, but further studies are needed to understand the interactions between the signaling pathways that lead to maturation promoting factor (MPF) being inactive or active. An improved understanding of the mechanisms involved in the control of bovine oocyte meiosis will facilitate better control of the process in vitro, resulting in increased developmental competence and increased efficiency of in vitro embryo production procedures. Copyright © 2011 Wiley Periodicals, Inc.

  6. Unsurfaced Road Maintenance Management

    Science.gov (United States)

    1992-12-01

    This draft manual describes an unsurfaced road maintenance management system for use on military installations. This system is available in either a manual or computerized mode (Micro PAVER). The maintenance standards prescribed should protect Govern...

  7. Winter maintenance performance measure.

    Science.gov (United States)

    2016-01-01

    The Winter Performance Index is a method of quantifying winter storm events and the DOTs response to them. : It is a valuable tool for evaluating the States maintenance practices, performing post-storm analysis, training : maintenance personnel...

  8. Movable bridge maintenance monitoring.

    Science.gov (United States)

    2013-10-01

    Movable bridges have particular maintenance issues, which cost considerably more than those of fixed bridges, : mostly because of the complex interaction of the mechanical, electrical and structural components. In order to track : maintenance and ope...

  9. TPX remote maintenance and shielding

    International Nuclear Information System (INIS)

    Rennich, M.J.; Nelson, B.E.

    1994-01-01

    The Tokamak Physics Experiment machine design incorporates comprehensive planning for efficient and safe component maintenance. Three programmatic decisions have been made to insure the successful implementation of this objective. First, the tokamak incorporates radiation shielding to reduce activation of components and limit the dose rate to personnel working on the outside of the machine. This allows most of the ex-vessel equipment to be maintained through conventional ''hands-on'' procedures. Second, to the maximum extent possible, low activation materials will be used inside the shielding volume. This resulted in the selection of Titanium (Ti-6Al-4V) for the vacuum vessel and PFC structures. The third decision stipulated that the primary in-vessel components will be replaced or repaired via remote maintenance tools specifically provided for the task. The component designers have been given the responsibility of incorporating maintenance design and for proving the maintainability of the design concepts in full-scale mockup tests prior to the initiation of final fabrication. Remote maintenance of the TPX machine is facilitated by general purpose tools provided by a special purpose design team. Major tools will include an in-vessel transporter, a vessel transfer system and a large component transfer container. In addition, tools such as manipulators and remotely operable impact wrenches will be made available to the component designers by this group. Maintenance systems will also provide the necessary controls for this equipment

  10. Measurements and evaluation of the risks due to external radiation exposures and to intake of activated elements for operational staff engaged in the maintenance of medical cyclotrons

    International Nuclear Information System (INIS)

    Calandrino, R.; Del Vecchio, A.; Parisi, R.; Todde, S.; De Felice, P.; Savi, A.; Pepe, A.; Mrskova, A.

    2010-01-01

    The aim of this paper is to assess the activation phenomena and to evaluate the risk of external exposure and intake doses for the maintenance staff of two medical cyclotrons. Two self-shielded cyclotrons are currently operating in the facility for the routine production of 11 C and 18 F. Four radiochemistry laboratories are linked to the cyclotrons by means of shielded radioisotope delivery lines. Radiopharmaceuticals are prepared both for the PET Diagnostic Dept., where four CT-PET scanners are operating with a mean patient workload of 40 d -1 and for [ 18 F]FDG external distribution, to provide radiopharmaceuticals for other institutions. In spite of the fact that air contamination inside the radiochemistry laboratories during the synthesis represents the largest 'slice of the pie' in the evaluation of annual intake dose, potential contamination due to the activated particulate, generated during cyclotron irradiation by micro-corrosion of targets and other components potentially struck by the proton beam and generated neutrons, should be considered. In this regard, the most plausible long-lived (T 1/2 > 30 d) radioisotopes formed are: 97 Tc, 56 Co, 57 Co, 58 Co, 60 Co, 49 V, 55 Fe, 109 Cd, 65 Zn and 22 Na. The results for the operating personnel survey has revealed only low-level contamination for 65 Zn in one test, together with minor 18 F intake, probably due to the environmental dispersion of the radioisotope during the [ 18 F] FDG synthesis. (authors)

  11. Measurements and evaluation of the risks due to external radiation exposures and to intake of activated elements for operational staff engaged in the maintenance of medical cyclotrons.

    Science.gov (United States)

    Calandrino, R; del Vecchio, A; Parisi, R; Todde, S; De Felice, P; Savi, A; Pepe, A; Mrskova, A

    2010-06-01

    The aim of this paper is to assess the activation phenomena and to evaluate the risk of external exposure and intake doses for the maintenance staff of two medical cyclotrons. Two self-shielded cyclotrons are currently operating in the facility for the routine production of (11)C and (18)F. Four radiochemistry laboratories are linked to the cyclotrons by means of shielded radioisotope delivery lines. Radiopharmaceuticals are prepared both for the PET Diagnostic Department, where four CT-PET scanners are operating with a mean patient workload of 40 d(-1) and for [(18)F]FDG external distribution, to provide radiopharmaceuticals for other institutions. In spite of the fact that air contamination inside the radiochemistry laboratories during the synthesis represents the largest 'slice of the pie' in the evaluation of annual intake dose, potential contamination due to the activated particulate, generated during cyclotron irradiation by micro-corrosion of targets and other components potentially struck by the proton beam and generated neutrons, should be considered. In this regard, the most plausible long-lived (T(1/2) > 30 d) radioisotopes formed are: (97)Tc, (56)Co, (57)Co, (58)Co, (60)Co, (49)V, (55)Fe, (109)Cd, (65)Zn and (22)Na. The results for the operating personnel survey has revealed only low-level contamination for (65)Zn in one test, together with minor (18)F intake, probably due to the environmental dispersion of the radioisotope during the [(18)F]FDG synthesis.

  12. A Field Study of Scale Economies in Software Maintenance

    OpenAIRE

    Rajiv D. Banker; Sandra A. Slaughter

    1997-01-01

    Software maintenance is a major concern for organizations. Productivity gains in software maintenance can enable redeployment of Information Systems resources to other activities. Thus, it is important to understand how software maintenance productivity can be improved. In this study, we investigate the relationship between project size and software maintenance productivity. We explore scale economies in software maintenance by examining a number of software enhancement projects at a large fi...

  13. Optimization of surface maintenance

    International Nuclear Information System (INIS)

    Oeverland, E.

    1990-01-01

    The present conference paper deals with methods of optimizing the surface maintenance of steel-made offshore installations. The paper aims at identifying important approaches to the problems regarding the long-range planning of an economical and cost effective maintenance program. The methods of optimization are based on the obtained experiences from the maintenance of installations on the Norwegian continental shelf. 3 figs

  14. Views of policy makers and health promotion professionals on factors facilitating implementation and maintenance of interventions and policies promoting physical activity and healthy eating: results of the DEDIPAC project.

    Science.gov (United States)

    Muellmann, Saskia; Steenbock, Berit; De Cocker, Katrien; De Craemer, Marieke; Hayes, Catherine; O'Shea, Miriam P; Horodyska, Karolina; Bell, Justyna; Luszczynska, Aleksandra; Roos, Gun; Langøien, Lars Jørun; Rugseth, Gro; Terragni, Laura; De Bourdeaudhuij, Ilse; Brug, Johannes; Pischke, Claudia R

    2017-12-06

    The uptake, implementation, and maintenance of effective interventions promoting physical activity (PA) and a healthy diet and the implementation of policies targeting these behaviors are processes not well understood. We aimed to gain a better understanding of what health promotion professionals and policy makers think are important factors facilitating adoption, implementation, and maintenance of multi-level interventions and policies promoting healthy eating and PA in Belgium, Germany, Ireland, Norway, and Poland. Six interventions and six policies were identified based on pre-defined criteria. Forty semi-structured interviews were conducted with stakeholders from various sectors to elicit information on factors impacting adoption, implementation, and maintenance of these interventions and policies. All interview transcripts were coded in NVivo, using a common categorization matrix. Coding in the respective countries was done by one researcher and validated by a second researcher. Active involvement of relevant stakeholders and good communication between coordinating organizations were described as important factors contributing to successful adoption and implementation of both interventions and policies. Additional facilitating factors included sufficient training of staff and tailoring of materials to match needs of various target groups. The respondents indicated that maintenance of implemented interventions/policies depended on whether they were embedded in existing or newly created organizational structures in different settings and whether continued funding was secured. Despite considerable heterogeneity of interventions and health policies in the five countries, stakeholders across these countries identify similar factors facilitating adoption, implementation, and maintenance of these interventions and policies.

  15. Improvement of Chicken Primordial Germ Cell Maintenance In Vitro by Blockade of the Aryl Hydrocarbon Receptor Endogenous Activity.

    Science.gov (United States)

    Pérez Sáez, Juan M; Bussmann, Leonardo E; Barañao, J Lino; Bussmann, Ursula A

    2016-06-01

    Primordial germ cells (PGCs) are the undifferentiated progenitors of gametes. Germline competent PGCs can be developed as a cell-based system for genetic modification in chickens, which provides a valuable tool for transgenic technology with both research and industrial applications. This implies manipulation of PGCs, which, in recent years, encouraged a lot of research focused on the study of PGCs and the way of improving their culture. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that besides mediating toxic responses to environmental contaminants plays pivotal physiological roles in various biological processes. Since a novel compound that acts as an antagonist of this receptor has been reported to promote expansion of hematopoietic stem cells, we conducted the present study with the aim of determining whether addition of an established AHR antagonist to the standard culture medium used nowadays for in vitro chicken PGCs culture improves ex vivo expansion. We have found that addition of α-naphthoflavone in culture medium promotes the amplification of undifferentiated cells and that this effect is exerted by the blockade of AHR action. Our results constitute the first report of the successful use of a readily available AHR antagonist to improve avian PGCs expansion, and they further extend the knowledge of the effects of AHR modulation in undifferentiated cells.

  16. Towards automated traceability maintenance.

    Science.gov (United States)

    Mäder, Patrick; Gotel, Orlena

    2012-10-01

    Traceability relations support stakeholders in understanding the dependencies between artifacts created during the development of a software system and thus enable many development-related tasks. To ensure that the anticipated benefits of these tasks can be realized, it is necessary to have an up-to-date set of traceability relations between the established artifacts. This goal requires the creation of traceability relations during the initial development process. Furthermore, the goal also requires the maintenance of traceability relations over time as the software system evolves in order to prevent their decay. In this paper, an approach is discussed that supports the (semi-) automated update of traceability relations between requirements, analysis and design models of software systems expressed in the UML. This is made possible by analyzing change events that have been captured while working within a third-party UML modeling tool. Within the captured flow of events, development activities comprised of several events are recognized. These are matched with predefined rules that direct the update of impacted traceability relations. The overall approach is supported by a prototype tool and empirical results on the effectiveness of tool-supported traceability maintenance are provided.

  17. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial.

    Science.gov (United States)

    Shaverdian, Narek; Lisberg, Aaron E; Bornazyan, Krikor; Veruttipong, Darlene; Goldman, Jonathan W; Formenti, Silvia C; Garon, Edward B; Lee, Percy

    2017-07-01

    Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. We assessed patients with advanced NSCLC treated on the phase 1 KEYNOTE-001 trial at a single institution (University of California, Los Angeles, CA, USA). Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or less, had adequate organ function, and no history of pneumonitis. Patients received pembrolizumab at a dose of either 2 mg/kg of bodyweight or 10 mg/kg every 3 weeks, or 10 mg/kg every 2 weeks, until disease progression, unacceptable toxicity, or other protocol-defined reasons for discontinuation. Disease response and pulmonary toxicity were prospectively assessed by Immune-related Response Criteria and Common Terminology Criteria for Adverse Events version 4.0. The primary objective of the KEYNOTE-001 trial was to assess the safety, side-effect profile, and antitumour activity of pembrolizumab. For our secondary analysis, patients were divided into subgroups to compare patients who previously received radiotherapy with patients who had not. Our primary objective was to determine whether previous radiotherapy affected progression-free survival, overall survival, and pulmonary toxicity in the intention-to-treat population. The KEYNOTE-001 trial was registered with ClinicalTrials.gov, number NCT01295827. Between May 22, 2012, and July 11, 2014, 98 patients were enrolled and received their first cycle of pembrolizumab. One patient was lost to follow-up. 42 (43%) of 97 patients had previously received any radiotherapy for the treatment of NSCLC before the first cycle of pembrolizumab. 38 (39%) of 97 patients received extracranial radiotherapy and 24 (25%) of 97 patients received thoracic radiotherapy. Median follow-up for surviving patients was 32·5

  18. Working memory capacity and the antisaccade task: A microanalytic-macroanalytic investigation of individual differences in goal activation and maintenance.

    Science.gov (United States)

    Meier, Matt E; Smeekens, Bridget A; Silvia, Paul J; Kwapil, Thomas R; Kane, Michael J

    2018-01-01

    The association between working memory capacity (WMC) and the antisaccade task, which requires subjects to move their eyes and attention away from a strong visual cue, supports the claim that WMC is partially an attentional construct (Kane, Bleckley, Conway, & Engle, 2001; Unsworth, Schrock, & Engle, 2004). Specifically, the WMC-antisaccade relation suggests that WMC helps maintain and execute task goals despite interference from habitual actions. Related work has recently shown that mind wandering (McVay & Kane, 2009, 2012a, 2012b) and reaction time (RT) variability (Unsworth, 2015) are also related to WMC and they partially explain WMC's prediction of cognitive abilities. Here, we tested whether mind-wandering propensity and intraindividual RT variation account for WMC's associations with 2 antisaccade-cued choice RT tasks. In addition, we asked whether any influences of WMC, mind wandering, or intraindividual RT variation on antisaccade are moderated by (a) the temporal gap between fixation and the flashing location cue, and (b) whether targets switch sides on consecutive trials. Our quasi-experimental study reexamined a published dataset (Kane et al., 2016) comprising 472 subjects who completed 6 WMC tasks, 5 attentional tasks with mind-wandering probes, 5 tasks from which we measured intraindividual RT variation, and 2 antisaccade tasks with varying fixation-cue gap durations. The WMC-antisaccade association was not accounted for by mind wandering or intraindividual RT variation. WMC's effects on antisaccade performance were greater with longer fixation-to-cue intervals, suggesting that goal activation processes-beyond the ability to control mind wandering and RT variability-are partially responsible for the WMC-antisaccade relation. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  19. Maintenance of nuclear power plants

    International Nuclear Information System (INIS)

    Migaud, D.; Hutin, J.P.; Jouette, I.; Eymond, P.; Devie, P.; Cudelou, C.; Magnier, S.; Frydman, M.

    2016-01-01

    This document gathers different articles concerning the maintenance of the French nuclear power plants. The first article analyses the impact of the recent law on the energetic transition that sets the share of nuclear power at 50% of the electricity produced by 2025. A consequence may be the decommissioning of 17 to 20 reactors by 2025 and the huge maintenance program called 'Grand Carenage' whose aim is to extend operating life over 40 years will have to be re-considered in order to avoid useless expenses. The second article shows that in 2015 the French nuclear reactor fleet got very good results in terms of availability and safety. There were 49 scheduled outages and among them some ended ahead of time. The third article describes the specificities of the maintenance of a nuclear power plant, for instance the redundancy of some systems implies that maintenance has to deal with systems that have never functioned but must be ready to operate at any moment. Another specificity is the complexity of a nuclear power plant that implies an essential phase of preparation for maintenance operations. Because of safety requirements any maintenance operation has to be controlled, checked and may provide feedback. The fourth article presents the 'Grand Carenage' maintenance program that involves the following operations: the replacement of steam generators, the re-tubing of condensers, the replacement of the filtering drums used for cooling water, the testing of the reactor building, the hydraulic test of the primary circuit and the inspection of the reactor vessel. The fifth article focuses on the organization of the work-site for maintenance operations and the example of the Belleville-sur-Loire is described in the sixth article. Important maintenance operations like 'Grand Carenage' requires a strong collaboration with a network of specialized enterprises and as no reactor (except Flamanville EPR) is being built in France, maintenance

  20. Building Maintenance. Student Learning Guide.

    Science.gov (United States)

    Palm Beach County Board of Public Instruction, West Palm Beach, FL.

    This student learning guide contains one module for completing a course in building maintenance. It is designed especially for use in secondary schools in Palm Beach County, Florida. The module covers one task, and consists of a purpose, performance objective, enabling objectives, learning activities keyed to resources, information sheets, student…

  1. Maintenance optimisation at Rovno NPP

    International Nuclear Information System (INIS)

    Hudson, R.

    2008-01-01

    The presentation gives up-to-date information about the implementations of the maintenance activities. 20+ Energoatom personnel trained have been in the RCM methodology. Make Up Water and Boric Acid Regulation System RCM analysis is complete. RCM Report, including RCM Software output, is complete. Supporting Safety Submission to SNRCU is currently being drafted. Comprehensive assessment of RNPP Condition Monitoring capabilities is near completion

  2. Modern electronic maintenance principles

    CERN Document Server

    Garland, DJ

    2013-01-01

    Modern Electronic Maintenance Principles reviews the principles of maintaining modern, complex electronic equipment, with emphasis on preventive and corrective maintenance. Unfamiliar subjects such as the half-split method of fault location, functional diagrams, and fault finding guides are explained. This book consists of 12 chapters and begins by stressing the need for maintenance principles and discussing the problem of complexity as well as the requirements for a maintenance technician. The next chapter deals with the connection between reliability and maintenance and defines the terms fai

  3. EPR design for maintenance

    International Nuclear Information System (INIS)

    Krugmann, U.

    1998-01-01

    Preventive maintenance is very important in achieving high plant availability. For the European Pressurized Reactor (EPR) preventive maintenance has been carefully addressed in the design stage. This is particularly necessary because of the traditionally different maintenance strategies employed in France and Germany. This paper emphasizes the following features introduced in the ERP design to minimize the duration of the refueling outage: (1) containment accessibility during power operation; (2) overall plant layout to facilitate inspections and maintenances within the containment; and (3) safety system design for enabling preventive maintenance during power operation. (author)

  4. Knowledge based maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, A. [Hamburgische Electacitaets-Werke AG Hamburg (Germany)

    1997-12-31

    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  5. Physical activity maintenance in the transition to adolescence: a longitudinal study of the roles of sport and lifestyle activities in British youth.

    Directory of Open Access Journals (Sweden)

    Hannah L Brooke

    Full Text Available Promoting physical activity in youth is important for health, but existing physical activity interventions have had limited success. We aimed to inform intervention design by i describing drop-out, continuation and uptake of specific activities over the transition to adolescence; and ii examining Variety (number of different activities/week and Frequency (number of activity session/week of activity participation and their associations with changes in objectively measured physical activity from childhood to adolescence.At age 10.2±0.3 and 14.2±0.3 years, 319 children in the SPEEDY study (46% boys wore GT1M Actigraph accelerometers for 7 days and provided self-reported participation (never, once, 2 to 3 times or four or more times, over the last 7 days in 23 leisure-time activities. Associations of change in moderate-to-vigorous intensity PA (MVPA (≥2000 counts/minute and change in total physical activity (TPA (average accelerometer counts/minute with exposure variables Z-score transformed (change in Variety and Frequency were examined using multilevel linear regression, clustered by school, in simple and adjusted models.The number of children ever reporting a specific activity ranged from 30 ('Hockey' to 279 ('Running or jogging'. Some activities were susceptible to drop-out (e.g. 'Skipping' but others were commonly continued or taken up (e.g. 'Household chores'. Overall, Variety and Frequency declined (mean±SD ΔVariety -3.1±4.4 activities/week; ΔFrequency -7.2±12.0 session/week. ΔMVPA and ΔTPA were not associated with Variety or Frequency at baseline, nor with ΔVariety or ΔFrequency (p>0.29 in all models.Popularity of specific activities as well as drop-out, continuation and uptake should be considered in future intervention development. Activities that are commonly continued or taken up may be more valuable to encourage in interventions than those with low participation or high drop-out. We did not find evidence to support the idea

  6. Physical Activity Maintenance in the Transition to Adolescence: A Longitudinal Study of the Roles of Sport and Lifestyle Activities in British Youth

    Science.gov (United States)

    Brooke, Hannah L.; Corder, Kirsten; Griffin, Simon J.; van Sluijs, Esther M. F.

    2014-01-01

    Background Promoting physical activity in youth is important for health, but existing physical activity interventions have had limited success. We aimed to inform intervention design by i) describing drop-out, continuation and uptake of specific activities over the transition to adolescence; and ii) examining Variety (number of different activities/week) and Frequency (number of activity session/week) of activity participation and their associations with changes in objectively measured physical activity from childhood to adolescence. Methods At age 10.2±0.3 and 14.2±0.3 years, 319 children in the SPEEDY study (46% boys) wore GT1M Actigraph accelerometers for 7 days and provided self-reported participation (never, once, 2 to 3 times or four or more times, over the last 7 days) in 23 leisure-time activities. Associations of change in moderate-to-vigorous intensity PA (MVPA) (≥2000 counts/minute) and change in total physical activity (TPA) (average accelerometer counts/minute) with exposure variables Z-score transformed (change in) Variety and Frequency were examined using multilevel linear regression, clustered by school, in simple and adjusted models. Results The number of children ever reporting a specific activity ranged from 30 (‘Hockey’) to 279 (‘Running or jogging’). Some activities were susceptible to drop-out (e.g. ‘Skipping’) but others were commonly continued or taken up (e.g. ‘Household chores’). Overall, Variety and Frequency declined (mean±SD ΔVariety −3.1±4.4 activities/week; ΔFrequency −7.2±12.0 session/week). ΔMVPA and ΔTPA were not associated with Variety or Frequency at baseline, nor with ΔVariety or ΔFrequency (p>0.29 in all models). Conclusions Popularity of specific activities as well as drop-out, continuation and uptake should be considered in future intervention development. Activities that are commonly continued or taken up may be more valuable to encourage in interventions than those with low participation or

  7. Impact of a male-only weight loss maintenance programme on social-cognitive determinants of physical activity and healthy eating: A randomized controlled trial.

    Science.gov (United States)

    Young, Myles D; Plotnikoff, Ronald C; Collins, Clare E; Callister, Robin; Morgan, Philip J

    2015-11-01

    To examine the effect of a gender-tailored, Social Cognitive Theory (SCT)-based weight loss maintenance (WLM) intervention on men's physical activity and healthy eating cognitions and behaviours in the 12 months after completing a weight loss programme. A two-phase, assessor-blinded, randomized controlled trial. Ninety-two overweight/obese men (mean [SD] age: 49.2 years [10.1], BMI: 30.7 [3.3] kg/m(2) ) who lost at least 4 kg after completing the 3-month SCT-based SHED-IT Weight Loss Program were randomly allocated to receive (1) the SCT-based SHED-IT WLM Program; or (2) no additional resources (self-help control group). The 6-month gender-tailored SHED-IT WLM Program was completely self-administered and operationalized SCT behaviour change principles to assist men to increase moderate-to-vigorous physical activity (MVPA) and decrease energy-dense, nutrient-poor (discretionary) food consumption after initial weight loss. After randomization (WLM baseline), men were reassessed at 6 months (WLM post-test) and 12 months (6-month WLM follow-up). SCT cognitions (e.g., self-efficacy, goal setting), MVPA, and discretionary food consumption were assessed with validated measures. Following significant improvements in cognitions, MVPA and discretionary food consumption during the weight loss phase, intention-to-treat, linear mixed models revealed no significant group-by-time differences in cognitions or behaviours during the WLM phase. Initial improvements in MVPA and some cognitions (e.g., goal setting, planning, and social support) were largely maintained by both groups at the end of the study. Dietary effects were not as strongly maintained, with the intervention and control groups maintaining 57% and 75% of the Phase I improvements in discretionary food intake, respectively. An additional SCT-based WLM programme did not elicit further improvements over a self-help control in the cognitions or behaviours for MVPA or discretionary food intake of men who had lost weight

  8. Innovation for maintenance technology improvements

    Science.gov (United States)

    Shives, T. R. (Editor); Willard, W. A. (Editor)

    1982-01-01

    A group of 34 submitted entries (32 papers and 2 abstracts) from the 33rd meeting of the Mechanical Failures Prevention Group whose subject was maintenance technology improvement through innovation. Areas of special emphasis included maintenance concepts, maintenance analysis systems, improved maintenance processes, innovative maintenance diagnostics and maintenance indicators, and technology improvements for power plant applications.

  9. Random maintenance policies

    CERN Document Server

    Nakagawa, Toshio

    2014-01-01

    Exploring random maintenance models, this book provides an introduction to the implementation of random maintenance, and it is one of the first books to be written on this subject.  It aims to help readers learn new techniques for applying random policies to actual reliability models, and it provides new theoretical analyses of various models including classical replacement, preventive maintenance and inspection policies. These policies are applied to scheduling problems, backup policies of database systems, maintenance policies of cumulative damage models, and reliability of random redundant systems. Reliability theory is a major concern for engineers and managers, and in light of Japan’s recent earthquake, the reliability of large-scale systems has increased in importance. This also highlights the need for a new notion of maintenance and reliability theory, and how this can practically be applied to systems. Providing an essential guide for engineers and managers specializing in reliability maintenance a...

  10. Reliability-Centered Maintenance

    Science.gov (United States)

    1978-12-29

    C. Mentzer, who directed khe pioneering studies of maintenance policy at United Airlines, and to the Federal Aviation Administration for creating...ANALYSIS 425 D-3 INFORMATION SCIENCi AND DECISION ANALYSIS 427 D-4 MAINTENANCE THEORY AND PHILOSOPHY 430 D-5 MAINTENANCE APPLUCATIONS 436 D-6 A GUIDE...occupants N Operational consequences, which involve an indirect economic loss as well as the direct cost of repair l Nonoperational consequences, which

  11. Status of fusion maintenance

    International Nuclear Information System (INIS)

    Fuller, G.M.

    1984-01-01

    Effective maintenance will be an essential ingredient in determining fusion system productivity. This level of productivity will result only after close attention is paid to the entire system as an entity and appropriate integration of the elements is made. The status of fusion maintenance is reviewed in the context of the entire system. While there are many challenging developmental tasks ahead in fusion maintenance, the required technologies are available in several high-technology industries, including nuclear fission

  12. Software evolution and maintenance

    CERN Document Server

    Tripathy, Priyadarshi

    2014-01-01

    Software Evolution and Maintenance: A Practitioner's Approach is an accessible textbook for students and professionals, which collates the advances in software development and provides the most current models and techniques in maintenance.Explains two maintenance standards: IEEE/EIA 1219 and ISO/IEC14764Discusses several commercial reverse and domain engineering toolkitsSlides for instructors are available onlineInformation is based on the IEEE SWEBOK (Software Engineering Body of Knowledge)

  13. Interactive videodisc in maintenance

    International Nuclear Information System (INIS)

    Zwingelstein, G.; Nguyen Van Nghi, B.

    1986-01-01

    After a recall of the videodisc characteristics, this paper presents its utilization by Electricite de France in the framework of training and maintenance. The SICMA (Interactive Communication System in Maintenance) developed and tested by Electricte de France is presented as also its utilization. It has been tested on the sites of Dampierre and Paluel in the cases of training and maintenance (deconnexion of drive rods of control elements); the conclusions of this experimentation are finally given. 4 refs [fr

  14. Turbine maintenance and modernization

    Energy Technology Data Exchange (ETDEWEB)

    Unga, E. [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1998-12-31

    The disturbance-free operation of the turbine plant plays an important role in reaching good production results. In the turbine maintenance of the Olkiluoto nuclear power plant the lifetime and efficiency of turbine components and the lifetime costs are taken into account in determining the turbine maintenance and modernization/improvement program. The turbine maintenance program and improvement/modernization measures taken in the plant units are described in this presentation. (orig.)

  15. Highlights from the previous volumes

    Science.gov (United States)

    Vergini Eduardo, G.; Pan, Y.; al., Vardi R. et; al., Akkermans Eric et; et al.

    2014-01-01

    Semiclassical propagation up to the Heisenberg time Superconductivity and magnetic order in the half-Heusler compound ErPdBi An experimental evidence-based computational paradigm for new logic-gates in neuronal activity Universality in the symmetric exclusion process and diffusive systems

  16. Army Maintenance System Transformation

    National Research Council Canada - National Science Library

    Gilbertson, Frank V

    2006-01-01

    .... Used in conjunction with pertinent historical data and developed with Army transformation goals in mind, General Systems thinking can provide the framework for guiding maintenance transformation...

  17. Industrial Maintenance Strategies

    International Nuclear Information System (INIS)

    Sajjad Akbar

    2006-01-01

    Industrial plants have become more complex due to technological advancement. This has made the task of maintenance more difficult. The maintenance costs in terms of resources and downtime loss are so high that maintenance function has become a critical factor in a plant's profitability. Industry should devote as much forethought to the management of maintenance function as to production. Maintenance has grown from an art to a precise, technical engineering science. Planning, organizing scheduling and control of maintenance using modern techniques pays dividends in the form of reduced costs and increased reliability. The magnitude and the dimension of maintenance have multiplied due to development in the engineering technologies. Production cost and capacities are directly affected by the breakdown time. Total operating cost including the maintenance cost plays an important role in replacement dimension. The integrated system approach would bring forth the desired results of high maintenance standards. The standards once achieved and sustained, would add to the reliability of the plan and relieve heavy stresses and strains on the engineering logistic support. (author)

  18. Remote Maintenance Monitoring System -

    Data.gov (United States)

    Department of Transportation — The Remote Maintenance and Monitoring System (RMMS) is a collection of subsystems that includes telecommunication components, hardware, and software, which serve to...

  19. Remote maintenance for fusion experimental reactor

    International Nuclear Information System (INIS)

    Koizumi, Koichi; Takeda, Nobukazu

    2000-01-01

    Here was introduced on maintenance of reactor core portion operated by remote control among maintenance of the International Thermonuclear Experimental Reactor (ITER) begun on its design since 1988 under international cooperation of U.S.A., Europe, Russia and Japan. Every appliances constructing the reactor core portion is necessary to carry out all of their inspection and maintenance by using remote controlled apparatus because of their radiation due to neutron generated by DT combustion of plasma. For engineering design activity (EDA) in ITER, not only design and development of the remote control appliances but also design under consideration of remote maintenance for from structural design of maintained objective appliances to access method to appliances, transportation and preservation method of radiated matters, and out-reactor maintenance in a hot cell, is now under progress. Here were also reported on basic concept on maintenance and conservation of ITER, maintenance design of diverter and blanket with high maintenance frequency and present state on development of maintenance appliances. (G.K.)

  20. 78 FR 26383 - Environmental Assessment of the Proposed Increase in Operation, Maintenance and Replacement...

    Science.gov (United States)

    2013-05-06

    ... Proposed Increase in Operation, Maintenance and Replacement Activities Associated With the Wasatch County... of potential impacts associated with a proposed change in Operation, Maintenance and Replacement..., Maintenance, and Replacement Proposed Action includes: stabilizing canal banks; lining, piping, or enclosing...

  1. Site Maintenance Plan: Part 2, Site Maintenance Action Plan for FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, E.L.

    1994-06-01

    This Fiscal Year (FY) 1994 Site Maintenance Action Plan (SMAP) is Part II of the Site Maintenance Plan, and has been written by Westinghouse Hanford Company (WHC) to outline the requirements stated in DOE Order 4330.4B, Maintenance Management Program, Chapter 1, Paragraph 3.3.1. The SMAP provides an annual status of maintenance initiatives completed and planned, a summary of performance indicators, a summary of maintenance backlog, a listing of real property and capital equipment maintenance cost estimates that were used to create the FY 1996 infrastructure and maintenance budget input, and a listing of proposed line item and general plant projects. Additionally, assumptions for various Site programs are listed to bring the Site Maintenance Plan into focus with overall Site activities. The primary mission at Hanford is to clean up the Site. In this cleanup process WHC will provide scientific and technological expertise to meet global needs, and partnership with stakeholders in the region to develop regional economic diversification. Other missions at the Hanford Site include energy research and development, and waste management and disposal activities. Their primary mission has a 30-year projected life span and will direct the shutting down and cleanup of defense production facilities and the Fast Flux Test Facility. This long-term mission requires continuous maintenance and in many instances, replacement of existing basic infrastructure, support facilities, and utilities. Without adequate maintenance and capital funding these infrastructure, support facilities, and utilities will continue to deteriorate causing an increase in backlogged work.

  2. Site Maintenance Plan: Part 2, Site Maintenance Action Plan for FY 1994

    International Nuclear Information System (INIS)

    Fisk, E.L.

    1994-06-01

    This Fiscal Year (FY) 1994 Site Maintenance Action Plan (SMAP) is Part II of the Site Maintenance Plan, and has been written by Westinghouse Hanford Company (WHC) to outline the requirements stated in DOE Order 4330.4B, Maintenance Management Program, Chapter 1, Paragraph 3.3.1. The SMAP provides an annual status of maintenance initiatives completed and planned, a summary of performance indicators, a summary of maintenance backlog, a listing of real property and capital equipment maintenance cost estimates that were used to create the FY 1996 infrastructure and maintenance budget input, and a listing of proposed line item and general plant projects. Additionally, assumptions for various Site programs are listed to bring the Site Maintenance Plan into focus with overall Site activities. The primary mission at Hanford is to clean up the Site. In this cleanup process WHC will provide scientific and technological expertise to meet global needs, and partnership with stakeholders in the region to develop regional economic diversification. Other missions at the Hanford Site include energy research and development, and waste management and disposal activities. Their primary mission has a 30-year projected life span and will direct the shutting down and cleanup of defense production facilities and the Fast Flux Test Facility. This long-term mission requires continuous maintenance and in many instances, replacement of existing basic infrastructure, support facilities, and utilities. Without adequate maintenance and capital funding these infrastructure, support facilities, and utilities will continue to deteriorate causing an increase in backlogged work

  3. Maintenance Optimization based on Mathematical Modeling

    NARCIS (Netherlands)

    de Jonge, Bram

    2017-01-01

    Due to an increasingly competitive marketplace and an ongoing shift from labor intensive to technology intensive industries, the importance of effectively planned and performed maintenance activities is growing. Because consequences of equipment failures are often severe, it is generally preferred

  4. Maintenance and Repair Support System (MARSS)

    National Research Council Canada - National Science Library

    Wessling

    1999-01-01

    ... (SSC), U.S. Army Test Maintenance Diagnostics Equipment Activity (TMDA), and the McDonnell Douglas Corporation, a wholly owned subsidiary of the Boeing Company, developed the first Pentium class body-wearable computer...

  5. Automating Contextualized Maintenance Documentation

    NARCIS (Netherlands)

    Koornneef, H.; Verhagen, W.J.C.; Curran, Ricky; Borsato, M.; Wognum, N.; Peruzzini, M.; Stjepandić, J.; Verhagen, W.J.C.

    2016-01-01

    Currently, task support information in aircraft maintenance is mostly provided using paper-based solutions, which are burdensome, slow and prone to error. Aircraft maintenance documentation contains vast amounts of information irrelevant for the task at hand and even for the simplest tasks multiple

  6. Maintenance optimization with AREVA

    Energy Technology Data Exchange (ETDEWEB)

    Kostroun, Frank; Herzing, Karl-Heinz; Buschart, Rufus [AREVA NP GmbH, Erlangen (Germany)

    2009-04-15

    Driven by the economic expectations of an energy market that becomes increasingly unregulated, the optimization of the maintenance in a nuclear power plant is a more demand practice. This paper describes on three exemplary product lines of AREVA, how AREVA can support its customers optimizing its maintenance.

  7. Maintenance Trades Guidelines

    Science.gov (United States)

    Weidner, Theodore J.

    2008-01-01

    In 2002, APPA published "Maintenance Staffing Guidelines for Educational Facilities," the first building maintenance trades staffing guideline designed to assist educational facilities professionals with their staffing needs. addresses how facilities professionals can determine the appropriate size and mix of their organization. Contents…

  8. Maintenance improvement program

    International Nuclear Information System (INIS)

    Derbonne, D.R.; Plunkett, T.F.; Simpson, J.R.

    1989-01-01

    During fuel cycle 1 at River Bend station, considerable effort was expended to reduce corrective maintenance work orders (MWOs) to <1,000. This was done by complementing the plant staff with costly contract personnel. Coming out of the first refueling outage, most contract personnel were released. The change in MWO backlog started a steady rise. It became readily apparent that to avoid costly contract staff time, a maintenance improvement program (MIP) was necessary. The MIP Was primarily directed at two areas: crew efficiency improvements and improved preplanned MWO packages. The overall effect of the MIP was to achieve significant productivity improvements with reduced operation and maintenance cost by providing frequent accountability to all levels of maintenance supervision. The MIP also produced a feeling of pride among the maintenance department employees that had not really existed before. This was the best benefit of all

  9. A Methodology for Modeling Nuclear Power Plant Passive Component Aging in Probabilistic Risk Assessment under the Impact of Operating Conditions, Surveillance and Maintenance Activities

    Science.gov (United States)

    Guler Yigitoglu, Askin

    In the context of long operation of nuclear power plants (NPPs) (i.e., 60-80 years, and beyond), investigation of the aging of passive systems, structures and components (SSCs) is important to assess safety margins and to decide on reactor life extension as indicated within the U.S. Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) Program. In the traditional probabilistic risk assessment (PRA) methodology, evaluating the potential significance of aging of passive SSCs on plant risk is challenging. Although passive SSC failure rates can be added as initiating event frequencies or basic event failure rates in the traditional event-tree/fault-tree methodology, these failure rates are generally based on generic plant failure data which means that the true state of a specific plant is not reflected in a realistic manner on aging effects. Dynamic PRA methodologies have gained attention recently due to their capability to account for the plant state and thus address the difficulties in the traditional PRA modeling of aging effects of passive components using physics-based models (and also in the modeling of digital instrumentation and control systems). Physics-based models can capture the impact of complex aging processes (e.g., fatigue, stress corrosion cracking, flow-accelerated corrosion, etc.) on SSCs and can be utilized to estimate passive SSC failure rates using realistic NPP data from reactor simulation, as well as considering effects of surveillance and maintenance activities. The objectives of this dissertation are twofold: The development of a methodology for the incorporation of aging modeling of passive SSC into a reactor simulation environment to provide a framework for evaluation of their risk contribution in both the dynamic and traditional PRA; and the demonstration of the methodology through its application to pressurizer surge line pipe weld and steam generator tubes in commercial nuclear power plants. In the proposed methodology, a

  10. Maintenance facilities, stores and records

    International Nuclear Information System (INIS)

    Fischer, K.

    1986-01-01

    The topics of this report are: on-site or off-site facilities. On-site facilities: workshops and special facilities. KWU's Service Center, a typical off-site supporting facility in Germany, capabilities and activities. A pool for special tools and equipment: devices for plugging of nozzles, for handling of RPU-studs and RPU internals etc. Devices for and management of radiological protection on-site for typical outage work. Spare parts and spare part management on site, typical examples. KWU's centralized spare part pools for components, generators and turbines etc. A computerized system for spare parts storage and maintenance planning. A system for mutual exchange of operational experience with respect to maintenance and repair activities. Systematic evaluation of failures and statistical results. (orig./GL)

  11. Mining Surveillance and Maintenance Dollars

    International Nuclear Information System (INIS)

    MARTINEZ, R.

    2000-01-01

    Accelerating site cleanup to reduce facility risks to the workers, the public and the environment during a time of declining federal budgets represents a significant technical and economic challenge to U.S. Department of Energy (DOE) Operations Offices and their respective contractors. A significant portion of a facility's recurring annual expenses are associated with routine, long-term surveillance and maintenance (S and M) activities. However, ongoing S and M activities do nothing to reduce risks and basically spend money that could be reallocated towards facility deactivation. This paper discusses the background around DOE efforts to reduce surveillance and maintenance costs, one approach used to perform cost reviews, lessons learned from field implementation and what assistance is available to assist DOE sites in performing these evaluations

  12. Design for maintenance during operation

    International Nuclear Information System (INIS)

    Barton, P.H.; Lyerly, H.D.

    1976-01-01

    Design of a nuclear power plant for safe, reliable and efficient operation involves much more than theory, regulations, regulatory guides, procedures, inspectors, and even quality assurance. It also involves a full knowledge and understanding of the activities which must be carried out to operate and maintain the plant. It must be remembered that a nuclear power plant is different from fossil designs and the designer must constantly keep in mind that access by people to every component is required for maintenance

  13. Maintenance cost models in deregulated power systems under opportunity costs

    International Nuclear Information System (INIS)

    Al-Arfaj, K.; Dahal, K.; Azaiez, M.N.

    2007-01-01

    In a centralized power system, the operator is responsible for scheduling maintenance. There are different types of maintenance, including corrective maintenance; predictive maintenance; preventive maintenance; and reliability-centred maintenance. The main cause of power failures is poor maintenance. As such, maintenance costs play a significant role in deregulated power systems. They include direct costs associated with material and labor costs as well as indirect costs associated with spare parts inventory, shipment, test equipment, indirect labor, opportunity costs and cost of failure. In maintenance scheduling and planning, the cost function is the only component of the objective function. This paper presented the results of a study in which different components of maintenance costs were modeled. The maintenance models were formulated as an optimization problem with single and multiple objectives and a set of constraints. The maintenance costs models could be used to schedule the maintenance activities of power generators more accurately and to identify the best maintenance strategies over a period of time as they consider failure and opportunity costs in a deregulated environment. 32 refs., 4 tabs., 4 figs

  14. Maintenance program guidelines for programmatic equipment

    International Nuclear Information System (INIS)

    1994-11-01

    The Division Directors at Lawrence Berkeley Laboratory are responsible for implementing a maintenance program for research equipment (also referred to as programmatic equipment) assigned to them. The program must allow maintenance to be accomplished in a manner that promotes operational safety, environmental protection and compliance, and cost effectiveness; that preserves the intended functions of the facilities and equipment; and that supports the programmatic mission of the Laboratory. Programmatic equipment -- such as accelerators, lasers, radiation detection equipment, and glove boxes -- is dedicated specifically to research. Installed equipment, by contrast, includes the mechanical and electrical systems installed as part of basic building construction, equipment essential to the normal functioning of the facility and its intended use. Examples of installed equipment are heating, ventilating, and air conditioning systems; elevators; and communications systems. The LBL Operating and Assurance Program Plan (PUB-3111, Revision 4) requires that a maintenance program be prepared for programmatic equipment and defines the basic maintenance program elements. Such a program of regular, documented maintenance is vital to the safety and quality of research activities. As a part of that support, this document offers guidance to Laboratory organizations for developing their maintenance programs. It clarifies the maintenance requirements of the Operating and Assurance Program (OAP) and presents an approach that, while not the only possibility, can be expected to produce an effective maintenance program for research equipment belonging to the Laboratory's organizations

  15. Maintenance for the Millennium: Another Approach

    International Nuclear Information System (INIS)

    Sculthorpe, Barruy R.

    2002-01-01

    Nuclear units nationwide are struggling to increase plant reliability and availability while at the same time reduce their operating and maintenance costs. Some very costly investments have been made in programs such as Reliability Centered Maintenance [RCM]. Florida Power and Light's approach at the St. Lucie Nuclear Plant has taken a slightly different approach. Building on our knowledge of the RCM process and an already existing 'World Class' Predictive Maintenance Program, a 'Condition-Based' Maintenance Program that takes advantage of the RCM philosophy and our toolbox full of advanced and highly successful predictive maintenance technologies. These tools currently consist of vibration analysis, lubricant analysis (both physical property and wear metals analysis, thermographic analysis, motor current signature analysis, tribology and process parameter trending. All employed with the intent to evaluate a machines health. This machine health check allows the forecasting of future preventative maintenance [PM's] tasks and the revision of existing PM's to maximize machine performance and eliminate 'no-value-added' maintenance activities/costs. Within the last year, the Condition-Based Maintenance Program has produced a cost saving of approximately $1.5 million dollars. As the program matures, these cost savings will accumulate well into the millennium. (authors)

  16. Asbestos exposure of building maintenance personnel.

    Science.gov (United States)

    Mlynarek, S; Corn, M; Blake, C

    1996-06-01

    The exposures of building maintenance personnel and occupants to airborne asbestos fibers, and the effects of operations and maintenance programs on those exposures, continue to be an important public health issue. The subject of this investigation was a large metropolitan county with numerous public buildings which routinely conducted air sampling for asbestos. A total of 302 personal air samples in nine task categories collected during maintenance worker activities in proximity to asbestos-containing materials were analyzed; 102 environmental air samples in four task categories were also analyzed. The arithmetic means of the 8-hr time weighted average exposures for personal sampling for each task category were all below the Occupational Safety and Health Administration permissible exposure level of 0.1 fibers (f)/cc > 5 microm. The highest mean 8-hr time weighted average exposure was 0.030 f/cc > 5 microm for ceiling tile replacement. The maximum asbestos concentration during sample collection for environmental samples was 0.027 f/cc > 5 microm. All asbestos-related maintenance work was done within the framework of an Operations and Maintenance Program (OMP) which utilized both personal protective equipment and controls against fiber release/dispersion. Results are presented in association with specific OMP procedures or controls. These results support the effectiveness of using Operations and Maintenance Programs to manage asbestos in buildings without incurring unacceptable risk to maintenance workers performing maintenance tasks.

  17. Manpower development for safe operation of nuclear power plant. China. Steam generator maintenance, cleaning and repair. Activity: 3.1.8-Task-04. Technical report

    International Nuclear Information System (INIS)

    Esposito, J.N.

    1994-01-01

    The objective of this mission was to present detailed state-of-the-art information on steam generator design, operations and maintenance, to the management, engineers and operators of the Qinshan Nuclear Power Plants. In addition, some limited operation was presented by the Qinshan Nuclear Power Plant representatives in order to aid in focussing the presentations and promoting a high level of discussion

  18. Maintenance Process Strategic Analysis

    Science.gov (United States)

    Jasiulewicz-Kaczmarek, M.; Stachowiak, A.

    2016-08-01

    The performance and competitiveness of manufacturing companies is dependent on the availability, reliability and productivity of their production facilities. Low productivity, downtime, and poor machine performance is often linked to inadequate plant maintenance, which in turn can lead to reduced production levels, increasing costs, lost market opportunities, and lower profits. These pressures have given firms worldwide the motivation to explore and embrace proactive maintenance strategies over the traditional reactive firefighting methods. The traditional view of maintenance has shifted into one of an overall view that encompasses Overall Equipment Efficiency, Stakeholders Management and Life Cycle assessment. From practical point of view it requires changes in approach to maintenance represented by managers and changes in actions performed within maintenance area. Managers have to understand that maintenance is not only about repairs and conservations of machines and devices, but also actions striving for more efficient resources management and care for safety and health of employees. The purpose of the work is to present strategic analysis based on SWOT analysis to identify the opportunities and strengths of maintenance process, to benefit from them as much as possible, as well as to identify weaknesses and threats, so that they could be eliminated or minimized.

  19. Program integration of predictive maintenance with reliability centered maintenance

    International Nuclear Information System (INIS)

    Strong, D.K. Jr; Wray, D.M.

    1990-01-01

    This paper addresses improving the safety and reliability of power plants in a cost-effective manner by integrating the recently developed reliability centered maintenance techniques with the traditional predictive maintenance techniques of nuclear power plants. The topics of the paper include a description of reliability centered maintenance (RCM), enhancing RCM with predictive maintenance, predictive maintenance programs, condition monitoring techniques, performance test techniques, the mid-Atlantic Reliability Centered Maintenance Users Group, test guides and the benefits of shared guide development

  20. Framework for Maintenance Planning

    DEFF Research Database (Denmark)

    Soares, C. Guedes; Duarte, J. Caldeira; Garbatov, Y.

    2010-01-01

    the design and during the whole life span of operational use, within an integrated framework founded on risk and reliability based techniques. The document addresses designers, decision makers and professionals responsible for or involved in establishing maintenance plans. The purpose of this document...... is to present maintenance as an integrated approach that needs to be planned, designed, engineered, and controlled by proper qualitative and quantitative techniques. This document outlines the basic premises for maintenance planning and provides the general philosophies that can be followed and points to a best...

  1. Mobile network maintenance (GSM)

    CERN Multimedia

    IT Department

    2009-01-01

    Maintenance work will be carried out on the CERN mobile network infrastructure (GSM) on the 23 and 24 July from 6 p.m. to 6 a.m. in order to replace discontinued equipment and to increase the bandwidth capacity of the GSM mobile network. All CERN GSM emitters (40 units) will be moved one by one to the new infrastructure during the maintenance. The call of a user connected to an emitter at the time of its maintenance will be cut off. However, the general overlapping of the GSM radio coverage should mean that users are able immediately to call again should their call be interrupted. IT/CS/CS

  2. Evaluation of maintenance strategies.

    Science.gov (United States)

    2013-11-01

    In the mid1990s, the Arizona Department of Transportation (ADOT) initiated the Maintenance Cost : Effectiveness study (SPR 371) with the development of plans and an experiment design to evaluate the : effectiveness of a variety of asphalt pavement...

  3. Experts' meeting: Maintenance '83

    International Nuclear Information System (INIS)

    1983-01-01

    The brochure presents, in full wording, 20 papers read at the experts' meeting ''Maintenance '83'' in Wiesbaden. Most of the papers discuss reliability data (acquisition, evaluation, processing) of nearly all fields of industry. (RW) [de

  4. Excellence through maintenance mastering

    International Nuclear Information System (INIS)

    Lamarche, M.; Guillot, M.; Monier, M.

    1987-01-01

    To improve the overall availability factor of nuclear power plants you have to cut either the forced outage role and the planned outage time or you need to reduce simultaneously the failures and the efforts devoted to avoiding them. Among other results, this goal leads to a decrease in the number of real or anticipated problems. Electricite de France policy, in this matter, is to focus on decreasing the compoents' maintenance needs through a comprehensive modification program, targeted to eliminating the weak points as revealed by the operation. Thereby one may reach, for simple equipment, a nearly maintenance-free condition in which the only maintenance needed is surveillance, which provides assurance that everything is operating properly. A good example of this type of equipment is the family of static components, drums, and pipes whose corrective maintenance is almost nil when their initial condition is good

  5. Procedures for maintenance and repairs

    International Nuclear Information System (INIS)

    Pickel, E.

    1981-01-01

    After a general review of the operation experience in the history of more than 12 operating years, the organization in the plant will be shown with special aspect to quality assurance, capacity of the workshops and connected groups as radiation protection, chemical laboratories etc. The number, time intervals and manpower effort for the repeating tests will be discussed. Reasons and examples for back-fitting activities in the plant are given. Besides special repair and maintenance procedures as repair of the steam generators, in-service inspection of the reactor pressure vessel, repair of a feed-water pipe and repair of the core structure in the pressure vessel, the general system to handle maintenance and repair-work in the KWO-plant will be shown. This includes also the detailed planning of the annual refueling and revision of the plant. (orig./RW)

  6. Factors Influencing Army Maintenance

    Science.gov (United States)

    1989-01-01

    Harz (1981), reports the results of questioning largc- numbers of Subject Matter Experts (SMEs) involved in the maintenance process. The second type of...identified maintenance problems (e.g., Kokenes, 1987; Harz , 1981). The second step was the identificatl i of demand factors that affect the actual...Kokenes, 1987; Harz , 1981). Second, if any of the data on which allocations are based are faulty, or budgetary decisions require a cutback in

  7. Predictive maintenance primer

    International Nuclear Information System (INIS)

    Flude, J.W.; Nicholas, J.R.

    1991-04-01

    This Predictive Maintenance Primer provides utility plant personnel with a single-source reference to predictive maintenance analysis methods and technologies used successfully by utilities and other industries. It is intended to be a ready reference to personnel considering starting, expanding or improving a predictive maintenance program. This Primer includes a discussion of various analysis methods and how they overlap and interrelate. Additionally, eighteen predictive maintenance technologies are discussed in sufficient detail for the user to evaluate the potential of each technology for specific applications. This document is designed to allow inclusion of additional technologies in the future. To gather the information necessary to create this initial Primer the Nuclear Maintenance Applications Center (NMAC) collected experience data from eighteen utilities plus other industry and government sources. NMAC also contacted equipment manufacturers for information pertaining to equipment utilization, maintenance, and technical specifications. The Primer includes a discussion of six methods used by analysts to study predictive maintenance data. These are: trend analysis; pattern recognition; correlation; test against limits or ranges; relative comparison data; and statistical process analysis. Following the analysis methods discussions are detailed descriptions for eighteen technologies analysts have found useful for predictive maintenance programs at power plants and other industrial facilities. Each technology subchapter has a description of the operating principles involved in the technology, a listing of plant equipment where the technology can be applied, and a general description of the monitoring equipment. Additionally, these descriptions include a discussion of results obtained from actual equipment users and preferred analysis techniques to be used on data obtained from the technology. 5 refs., 30 figs

  8. Maintenance of scientific instruments

    International Nuclear Information System (INIS)

    Lucero, E.

    1986-01-01

    During the last years Colombia has increased the use of nuclear techniques, instruments and equipment in ambitious health programs, as well as in research centers, industry and education; this has resulted in numerous maintenance problems. As an alternative solution IAN has established a Central Maintenance Laboratory for nuclear instruments within an International Atomic Energy Agency program for eight Latin American and nine Asian Countries. Established strategies and some results are detailed in this writing

  9. TFTR remote maintenance

    International Nuclear Information System (INIS)

    Bonanos, P.; Lontai, L.

    1977-01-01

    The Tokamak Fusion Test Reactor (TFTR) is the first tokamak designed to utilize tritium plasmas and achieve significant neutron yields. Tritium operations are scheduled for the early 1980's at the Princeton Plasma Physics Laboratory. Complex operations of unprecedented scale must be performed remotely. The design of TFTR and the maintenance system supporting it are developing in parallel. The nature of the problem and a proposed set of maintenance tools are described

  10. Remote maintenance development

    International Nuclear Information System (INIS)

    Zook, C.R.

    1979-01-01

    The concept of remote maintenance as it pertains to nuclear fuel fabrication facilities is quite unique. The future may require completely remote facilities where maintenance will be performed by hybrid manipulators/robots. These units will be capable of being preprogrammed for automatic operation or manually operated with the operator becoming a part of the closed loop control system. These robots will mesh television, computer control, and direct force feedback manual control in a usable new concept of robotics

  11. Mechanical configuration and maintenance

    International Nuclear Information System (INIS)

    Brown, T.G.; Casini, G.; Churakov, G.F.

    1982-01-01

    The INTOR engineering design has been strongly influenced by considerations for assembly and maintenance. A maintenance philosophy was established at the outset of the conceptual design to insure that the tokamak configuration would be developed to accommodate maintenance requirements. The main features of the INTOR design are summarized in this paper with primary emphasis on the impact of maintenance considerations. The most apparent configuration design feature is the access provided for torus maintenance. Particular attention was given to the size and location of superconducting magnets and the location of vacuum boundaries. All of the poloidal field (PF) coils are placed outside of the bore of the toroidal field (TF) coils and located above and below an access opening between adjacent TF coils through which torus sectors are removed. A magnet structural configuration consisting of mechanically attached reinforcing members has been designed which facilitates the open access space for torus sector removal. For impurity control, a single null poloidal divertor was selected over a double null design in order to maintain sufficient access for pumping and maintenance of the collector. A double null divertor was found to severely limit access to the torus with the addition of divertor collectors and pumping at the top. For this reason, a single null concept was selected in spite of the more difficult design problems associated with the required asymmetric PF system and higher particle loadings

  12. Activities for turbine maintenance: planning, implementation and evaluation of inspection results; Actividades para el mantenimiento de la turbina: planificacion, ejecucion y evaluacion de resultados de las inspecciones

    Energy Technology Data Exchange (ETDEWEB)

    Azcue, J.; Sanchez, M. A.; Alvaro, M.

    2014-04-01

    The article will cover the most significant aspects of how Tecnatom carry out the turbine maintenance work, both from the point of view of the inspection itself as the pre-and post tasks associated. Thus, the issues that will be part of the article are the Manual Inspection Service (MISI) and the inspection database, ISI WEB. These tools are essential for planning field work and serve as a guide to run later turbine inspections in different plants. Following this introduction the inspection teams and the techniques used by Tecnatom will be described. finally, the article will contain a small mention about management studies of life and integrity analysis of the turbine that can be performed, as well as involvement in its safe operation that is derived from them. Ultimately, the intention is to provide a comprehensive approach to the issue in question, the turbine maintenance work, so that the reader can get an ideal of the whole process. (Author)

  13. Manpower development for safe operation of nuclear power plant. China. Advice on maintenance planning. Activity: 3.1.2-Task-06. Technical report

    International Nuclear Information System (INIS)

    Chihara, Yasutaka; Imai, Kazuhide.

    1995-01-01

    Advice on maintenance planning for Qinshan nuclear power plant in China for their reference, based on the experience in Japan is presented. Specifically, the advice was given in the lecture and through the questions and answers, on such subjects as the establishment of a long-term plan, preparation of the work schedule, and the proper work management in relation to the periodic inspection and the routine check for the nuclear power facility. 1 tab

  14. Increasing the competitiveness of maintenance contract rates by using an alternative methodology for the calculation of average vehicle maintenance costs

    Directory of Open Access Journals (Sweden)

    Stephen Carstens

    2008-11-01

    Full Text Available Companies tend to outsource transport to fleet management companies to increase efficiencies if transport is a non-core activity. The provision of fleet management services on contract introduces a certain amount of financial risk to the fleet management company, specifically fixed rate maintenance contracts. The quoted rate needs to be sufficient and also competitive in the market. Currently the quoted maintenance rates are based on the maintenance specifications of the manufacturer and the risk management approach of the fleet management company. This is usually reflected in a contingency that is included in the quoted maintenance rate. An alternative methodology for calculating the average maintenance cost for a vehicle fleet is proposed based on the actual maintenance expenditures of the vehicles and accepted statistical techniques. The proposed methodology results in accurate estimates (and associated confidence limits of the true average maintenance cost and can beused as a basis for the maintenance quote.

  15. Differing antidepressant maintenance methodologies.

    Science.gov (United States)

    Safer, Daniel J

    2017-10-01

    The principle evidence that antidepressant medication (ADM) is an effective maintenance treatment for adults with major depressive disorder (MDD) is from placebo substitution trials. These trials enter responders from ADM efficacy trials into randomized, double-blind placebo-controlled (RDBPC) effectiveness trials to measure the rate of MDD relapse over time. However, other randomized maintenance trial methodologies merit consideration and comparison. A systematic review of ADM randomized maintenance trials included research reports from multiple databases. Relapse rate was the main effectiveness outcome assessed. Five ADM randomized maintenance methodologies for MDD responders are described and compared for outcome. These effectiveness trials include: placebo-substitution, ADM/placebo extension, ADM extension, ADM vs. psychotherapy, and treatment as usual. The placebo-substitution trials for those abruptly switched to placebo resulted in unusually high (46%) rates of relapse over 6-12months, twice the continuing ADM rate. These trials were characterized by selective screening, high attrition, an anxious anticipation of a switch to placebo, and a risk of drug withdrawal symptoms. Selectively screened ADM efficacy responders who entered into 4-12month extension trials experienced relapse rates averaging ~10% with a low attrition rate. Non-industry sponsored randomized trials of adults with multiple prior MDD episodes who were treated with ADM maintenance for 1-2years experienced relapse rates averaging 40%. Placebo substitution trial methodology represents only one approach to assess ADM maintenance. Antidepressant maintenance research for adults with MDD should be evaluated for industry sponsorship, attrition, the impact of the switch to placebo, and major relapse differences in MDD subpopulations. Copyright © 2017. Published by Elsevier Inc.

  16. JRR-3 maintenance program utilizing accumulated maintenance data

    International Nuclear Information System (INIS)

    Izumo, Hironobu; Kato, Tomoaki; Kinase, Masami; Torii, Yoshiya; Murayama, Yoji

    2007-07-01

    JRR-3(Japan Research Reactor No.3) has been operated for more than 15 years after the modification, without significant troubles by carrying out maintenance such as the preventive maintenance (mainly time-based maintenance) for the safety-grade equipments and the breakdown maintenance for the non-safety-grade equipments. Unscheduled shutdowns causes by aged non-safety-grade equipments have been increasing, and the resources such as budgets have been decreasing year by year. In this situation, JRR-3 maintenance program was reviewed about safety, reliability and economic efficiency. This report offers the policy of the maintenance review and the future direction of maintenance programs. (author)

  17. Good practices for cost effective maintenance of nuclear power plants

    International Nuclear Information System (INIS)

    1997-02-01

    This publication is organized around five areas that were identified by the utilities and government organizations who contributed to this report as most important to them. They are: Increasing production through maintenance activities related to improved plant material condition, reduced duration of planned outages, use of on-line maintenance and reduced frequency of forced outages; reducing workload through avoiding unnecessary regulatory burden and using reliability centered maintenance and condition monitoring; improving maintenance processes through better planning and scheduling, use of information management systems, graduated work controls, and appropriate post-maintenance testing; improving productivity through better teamwork, greater sharing of resources, and better radiation management associated with maintenance; measuring performance of maintenance activities through such tools as performance measures and benchmarking. Figs, tabs

  18. Methadone maintenance treatment programme reduces criminal activity and improves social well-being of drug users in China: a systematic review and meta-analysis.

    Science.gov (United States)

    Sun, Hua-Min; Li, Xiao-Yan; Chow, Eric P F; Li, Tong; Xian, Yun; Lu, Yi-Hua; Tian, Tian; Zhuang, Xun; Zhang, Lei

    2015-01-08

    Methadone maintenance treatment (MMT) has been implemented in China since 2004 and has expanded into a nationwide programme. This study aims to evaluate changes in social functioning, family relations and drug-related criminal behaviour among MMT clients in China. Systematic review and meta-analysis. Both English and Chinese literature databases, including PubMed, Chongqing VIP Chinese Science and Technology Journals Database (CQVIP), China National Knowledge Infrastructure (CNKI) and Wanfang Data, were comprehensively searched over the period 2004-2014 for studied indicators. Study selection, quality assessment and data extraction were conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) Statement. Meta-analyses were conducted using Comprehensive Meta-Analysis Biostat software. Thirty-eight articles were included in this review (1 in English and 37 in Chinese). The self-reported arrest rate decreased from 13.1% (95% CI 9.1% to 18.5%) at baseline to 3.4% (95% CI 1.5% to 7.7%) and 4.3% (95% CI 1.6% to 11.4%) after 6 and 12 months of MMT intervention, respectively. The rate of drug selling decreased from 7.6% (95% CI 3.8% to 14.8%) at baseline to 1.9% (95% CI 0.6% to 6.2%) and 3.0% (95% CI 1.0% to 8.9%) after 6 and 12 months of intervention, respectively. Similarly, the rates of selling sex for drugs and drug-related crime decreased from 5.3% (95% CI 2.4% to 11.1%) and 9.9% (95% CI 6.8% to 14.2%) at baseline to 1.1% (95% CI 0.5% to 2.3%) and 3.4% (95% CI 2.5% to 4.5%) at 6 months, then to 0.8% (95% CI 0.3% to 1.9%) and 3.4% (95% CI 0.8% to 13.1%) at 12 months after treatment initiation, respectively. In contrast, the rate of employment of clients and the proportion of clients having a good relationship with their family increased substantially from 26.4% (95% CI 22.9% to 30.1%) and 37.9% (95% CI 32.0% to 44.2%) to 41.6% (95% CI 36.6% to 48.0%) and 59.6% (95% CI 48.1% to 70.2%) at 6 months, then to 59.8% (95

  19. Maintenance and Outage Management Assessment (MOMA)

    International Nuclear Information System (INIS)

    2005-01-01

    The competitive environment has significant implications for nuclear power plant (NPP) operations, which include, inter alia, the need for efficient use of resources and effective management of plant activities of maintenance and outages. The purpose of NPP maintenance and outages is to allow NPPs to use all those functions necessary for safe and reliable power production by keeping them available and adequate maintenance programme is essential. The maintenance programme covers all preventive and remedial measures, both administrative and technical, necessary to identify and mitigate degradation of a functioning system, structure or component, or restore the design functions of a failed system, structure or component to an acceptable level. In response to the needs of MSs, NPES (Nuclear Power Section, Division of Nuclear Power, IAEA) plans to strengthen its services. NPES services will not only continue to provide its 'traditional' products of publications of nuclear industrial best practices and technical implementation of TC projects on plant maintenance and outage management, but also be expanded to deliver, in a timely manner, technical support missions as requested by MSs for NPPs. One of many services is Maintenance and Outage Management Assessment (MOMA). The NPP can obtain support and assistance in assessment and optimisation of its maintenance program and/or outage management. It aims to help the NPP improve its performance of maintenance and outage in a competitive nuclear power business environment. The specific benefits of the assessment are as follows: a) disseminate nuclear industrial best practices on maintenance program and outage management in the world, b) benchmark, evaluate and optimise the approach of maintenance program and outage management and c) identify solutions to known problems at nuclear power plants, if any. MOMA is conducted at the request of NPPs of any IAEA Member States. MOMA consists in a technical mission/visit for 1-3 weeks by

  20. Maintenance rule: a system to guarantee maintenance effectiveness

    International Nuclear Information System (INIS)

    Torralbo, J.R.

    1995-01-01

    In the last few years, maintenance activities in nuclear plants have been given prime attention in view of their repercussion on the performance of such plants. One of the results of that attention is a new rule published in the U.S. known as M aintenance Rule . The paper describes the philosophy and main guidelines of the new regulation, and presents the procedure brought into action by the nuclear industry in Spain so to make their application contribute to a real improvement of safety and performance in nuclear plants. (Author)

  1. Building Maintenance, Management, and Budgeting.

    Science.gov (United States)

    Pawsey, M. R.

    1982-01-01

    Australian methods and formulas for funding building maintenance and management are outlined and found to be haphazard. Discussed are: ultimate costs of deferred maintenance, major plant replacements, life cycle costing, types of maintenance programs (including full preventive maintenance), use of computer programs for planning, and organization…

  2. A joint spare part and maintenance inspection optimisation model using the Delay-Time concept

    International Nuclear Information System (INIS)

    Wang Wenbin

    2011-01-01

    Spare parts and maintenance are closely related logistics activities where maintenance generates the need for spare parts. When preventive maintenance is present, it may need more spare parts at one time because of the planned preventive maintenance activities. This paper considers the joint optimisation of three decision variables, e.g., the ordering quantity, ordering interval and inspection interval. The model is constructed using the well-known Delay-Time concept where the failure process is divided into a two-stage process. The objective function is the long run expected cost per unit time in terms of the three decision variables to be optimised. Here we use a block-based inspection policy where all components are inspected at the same time regardless of the ages of the components. This creates a situation that the time to failure since the immediate previous inspection is random and has to be modelled by a distribution. This time is called the forward time and a limiting but closed form of such distribution is obtained. We develop an algorithm for the optimal solution of the decision process using a combination of analytical and enumeration approaches. The model is demonstrated by a numerical example. - Highlights: → Joint optimisation of maintenance and spare part inventory. → The use of the Delay-Time concept. → Block-based inspection. → Fixed order interval but variable order quantity.

  3. The MERC maintenance system

    International Nuclear Information System (INIS)

    Izquierdo, J.J.; Chauvire, P.; Plessis, L.

    1991-01-01

    Maintenance in the modern commercial reprocessing plants is a subject of the highest priority in order to guarantee availability for the whole life of the plant. The design concept of the UP3 reprocessing plant at La Hague identified several categories of equipment according to their maintenance design principles. Among them, Standard Process Equipment such as pumps, valves, ejectors and filters which need periodic maintenance. These equipment items are designed in removable modular form to avoid the need to disconnect piping. Removal is performed under shielding and without breach of containment through the use of a transfer cask that is connected to the cell containing the equipment to be removed. This transfer cask is called MERC (Mobile Equipment Replacement Cask). Containment is preserved by an air-tight system consisting of coupled doors, with a special connecting gasket. This system can remove and replace failed equipment, without spreading contamination to work areas. (author)

  4. Optimum Maintenance Strategies for Highway Bridges

    DEFF Research Database (Denmark)

    Frangopol, Dan M.; Thoft-Christensen, Palle; Das, Parag C.

    As bridges become older and maintenance costs become higher, transportation agencies are facing challenges related to implementation of optimal bridge management programs based on life cycle cost considerations. A reliability-based approach is necessary to find optimal solutions based on minimum...... expected life-cycle costs or maximum life-cycle benefits. This is because many maintenance activities can be associated with significant costs, but their effects on bridge safety can be minor. In this paper, the program of an investigation on optimum maintenance strategies for different bridge types...... is described. The end result of this investigation will be a general reliability-based framework to be used by the UK Highways Agency in order to plan optimal strategies for the maintenance of its bridge network so as to optimize whole-life costs....

  5. Modularity Design Approach for Preventive Machine Maintenance

    Science.gov (United States)

    Ernawati, D.; Pudji, E.; Ngatilah, Y.; Handoyo, R.

    2018-01-01

    In a company, machine maintenance system will be very influential in production process activity. The company should have a scheduled engine maintenance system that does not require high costs when repairing and replacing machine parts. Modularity Design method is able to provide solutions to the engine maintenance scheduling system and can prevent fatal damage to the engine components. It can minimize the cost of repair and replacement of these machine components.The paper provides a solution to machine maintenance problems. The paper is also completed with case study of milling machines. That case studies can give us a real description about impact implementation of modularity design to prevent fatal damage to components and minimize the cost of repair and replacement of components of the machine.

  6. Safety of nuclear operation and maintenance

    International Nuclear Information System (INIS)

    Mori, M.; Nitta, T.; Sakai, K.

    1994-01-01

    The Kansai Electric Power Co. Inc.(Kansai EPC) aims to pursue a high quality and highly reliable operation in nuclear power generation in order to ensure safety by reducing the risk of accidents and win the confidence from the society and the public. It is emphasised that in order to realize this aim manufacturers and contractors cooperate with each other in performing high quality maintenance through plant lifetime maintenance system. TQC (Total Quality Control) activity enhances the motivation for each individual to have a quality-oriented mind and cultivate the safety culture. Under the lifetime employment practice, Kansai EPC and maintenance contractors can conduct systematic education and training, and the Maintenance Training Center helps to make it effective. 6 figs

  7. Maintenance simulation: Software issues

    Energy Technology Data Exchange (ETDEWEB)

    Luk, C.H.; Jette, M.A.

    1995-07-01

    The maintenance of a distributed software system in a production environment involves: (1) maintaining software integrity, (2) maintaining and database integrity, (3) adding new features, and (4) adding new systems. These issues will be discussed in general: what they are and how they are handled. This paper will present our experience with a distributed resource management system that accounts for resources consumed, in real-time, on a network of heterogenous computers. The simulated environments to maintain this system will be presented relate to the four maintenance areas.

  8. Training of maintenance personnel

    International Nuclear Information System (INIS)

    Rabouhams, J.

    1986-01-01

    This lecture precises the method and means developed by EDF to ensure the training of maintenance personnel according to their initial educational background and their experience. The following points are treated: General organization of the training for maintenance personnel in PWR and GCR nuclear power stations and in Creys Malville fast breeder reactor; Basic nuclear training and pedagogical aids developed for this purpose; Specific training and training provided by contractors; complementary training taking into account the operation experience and feedback; Improvement of velocity, competence and safety during shut-down operations by adapted training. (orig.)

  9. Predictive maintenance: A new approach in maintenance of nuclear power plants

    International Nuclear Information System (INIS)

    Benvenuto, F.; Ferrari, L.

    2005-01-01

    The maintenance services for a Nuclear Power Plant are in general aimed at reaching the following goals: - Increase component availability and consequently decrease intervention frequency; - Reduce unexpected costs from unexpected repairs; - Progressively decrease the time of each intervention; - Improve the spare parts supply efficiency; - Improve spare parts and consumable warehouse managing; - Decrease maintenance costs. Most of the currently used maintenance activities refer to run-to-failure or preventive approaches: - Run-to-failure or Corrective Maintenance means that work is only carried out when a component or system is faulty and unable to perform its critical function. Non critical components such as filters or components with spare may be maintained in this way; - Preventive or Scheduled Maintenance involves a regular pre-set schedule programme of maintenance work. Programme outlined by the manufacturer of the component in question based on the design life of the component and based on past experience by operation. One step further than Preventive Maintenance is represented by Predictive Maintenance. Whereas Preventive Maintenance bases its schedules on past performance data, a predictive system acquires condition data from the machine to be maintained whilst the machine is in operation. The information obtained from this analysis indicates the condition in real time, provides a diagnosis of wear and shows any trend towards critical conditions. Predictive maintenance mainly consists of the following interventions: - Lubricant analysis; - Collection / analysis of functional parameters, such as motor absorption, flow rate, pressure, temperature, noise, vibration of rotating equipment, thermal efficiency, etc; - Periodical test of lifting systems; - Other operations to acquire sensitive equipment parameters. Predictive Maintenance can reduce the accidental intervention and extend the components life, and, in the end, is increasing the global availability

  10. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  11. Tiers of the maintenance concept at ALMA in operations

    Science.gov (United States)

    Rabanus, David

    2014-08-01

    The Atacama Large Millimeter/submillimeter Array finds itself in the transition into full operations. Previous construction activities are being wrapped up, and regular, repetitive maintenance and upkeep will dominate the daily life, which asks for a consolidation and streamlining of the activities at the observatory. Especially the shifting focus to the high site of the observatory deserves more attention, since assembly, integration and verification activities at the base camp have ceased by now. In parallel, adjustments in the host country's labor legislation for operations at high geographic altitudes demand a review of the way things are done. This talk outlines the underlying operational concepts, lists the limiting constraints, describes the implementation of our reactions to those, and outlines our future intentions, which will be one in a number of steps towards optimization of the productivity of the observatory. The latter is the top level goal, which the Joint ALMA Observatory (JAO) has signed up for.

  12. Diesel Vehicle Maintenance Competencies.

    Science.gov (United States)

    Braswell, Robert; And Others

    Designed to provide a model set of competencies, this manual presents tasks which were identified by employers, employees, and teachers as important in a postsecondary diesel vehicle maintenance curriculum. The tasks are divided into seven major component areas of instruction: chassis and suspension, diesel engines, diesel fuel, electrical,…

  13. CH Packaging Maintenance Manual

    International Nuclear Information System (INIS)

    Washington TRU Solutions

    2002-01-01

    This procedure provides instructions for performing inner containment vessel (ICV) and outer containment vessel (OCV) maintenance and periodic leakage rate testing on the following packaging seals and corresponding seal surfaces using a nondestructive helium (He) leak test. In addition, this procedure provides instructions for performing ICV and OCV structural pressure tests

  14. Maintenance: problem and solution

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Equipment that is often unique, machines that are as old as the Laboratory, continuous and demanding performance requirements: these are the challenges faced by CERN’s accelerator maintenance teams. There are some twenty such teams, attached to different departments. A new project aims to standardise their procedures to make their work easier, and you can be a part of it.   “For the past year or so, the Accelerator and Technologies Sector and the GS Department have been working together on identifying the needs of the different teams that perform maintenance on CERN’s equipment. We are now ready to provide computer support with detailed specifics about the processes that need to be set up,” explains Goran Perinić, one of the leaders in CERN’s new Maintenance Management project (MMP). Since the LHC entered operation, the responsibilities of the technical teams have been broadened to cover maintenance of the collider and that of its injectors...

  15. Building Maintenance Syllabus.

    Science.gov (United States)

    Fischer, Joseph; Messier, Joseph

    Building maintenance is a basic two-year trade education course requiring 2 1/2 hours of study on each of 160 teaching days per year. Student abilities should range from those capable of the simplest custodial work to those who may eventually be superintendents of building complexes. The syllabus is organized in sections by traditional skills…

  16. Telephone Exchange Maintenance

    CERN Multimedia

    2005-01-01

    Urgent maintenance work on CERN telephone exchanges will be performed on 24 March from 6 a.m. to 8 a.m. Telephone services may be disrupted or even interrupted during this time. For more details, please contact us by email at Standard.Telephone@cern.ch.

  17. Little languages : little maintenance?

    NARCIS (Netherlands)

    A. van Deursen (Arie); P. Klint (Paul)

    1997-01-01

    textabstractSo-called little, or domain-specific languages (DSLs), have the potential to make software maintenance simpler: domain-experts can directly use the DSL to make required routine modifications. At the negative side, however, more substantial changes may become more difficult: such changes

  18. Operations and maintenance philosophy

    International Nuclear Information System (INIS)

    DUNCAN, G.P.

    1999-01-01

    This Operations and Maintenance (O and M) Philosophy document is intended to establish a future O and M vision, with an increased focus on minimizing worker exposure, ensuring uninterrupted retrieval operations, and minimizing operation life-cycle cost. It is intended that this document would incorporate O and M lessons learned into on-going and future project upgrades

  19. Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill--a double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive.

    Science.gov (United States)

    Gingnell, Malin; Engman, Jonas; Frick, Andreas; Moby, Lena; Wikström, Johan; Fredrikson, Mats; Sundström-Poromaa, Inger

    2013-07-01

    Most women on combined oral contraceptives (COC) report high levels of satisfaction, but 4-10% complain of adverse mood effects. The aim of this randomized, double-blinded, placebo-controlled trial was to investigate if COC use would induce more pronounced mood symptoms than placebo in women with previous history of COC-induced adverse mood. A second aim was to determine if COC use is associated with changes in brain reactivity in regions previously associated with emotion processing. Thirty-four women with previous experience of mood deterioration during COC use were randomized to one treatment cycle with a levonorgestrel-containing COC or placebo. An emotional face matching task (vs. geometrical shapes) was administered during functional magnetic resonance imaging (fMRI) prior to and during the COC treatment cycle. Throughout the trial, women recorded daily symptom ratings on the Cyclicity Diagnoser (CD) scale. During the last week of the treatment cycle COC users had higher scores of depressed mood, mood swings, and fatigue than placebo users. COC users also had lower emotion-induced reactivity in the left insula, left middle frontal gyrus, and bilateral inferior frontal gyri as compared to placebo users. In comparison with their pretreatment cycle, the COC group had decreased emotion-induced reactivity in the bilateral inferior frontal gyri, whereas placebo users had decreased reactivity in the right amygdala. COC use in women who previously had experienced emotional side effects resulted in mood deterioration, and COC use was also accompanied by changes in emotional brain reactivity. These findings are of relevance for the understanding of how combined oral contraceptives may influence mood. Placebo-controlled fMRI studies in COC sensitive women could be of relevance for future testing of adverse mood effects in new oral contraceptives. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Operations and maintenance plan : Dallas Integrated Corridor Management (ICM) demonstration project.

    Science.gov (United States)

    This Operations and Maintenance (O&M) Plan describes how the Integrated Corridor Management System (ICMS) will be used in daily transportation operations and maintenance activities. The Plan addresses the activities needed to effectively operate the ...

  1. Towards total productive maintenance in the Eastern European mining industry

    Energy Technology Data Exchange (ETDEWEB)

    Buck, J.D. [Kepner-Tregoe (United Kingdom) Ltd., Windsor

    1999-08-01

    An European Union consultancy project was undertaken to install a `best-in-class` maintenance system for the lignite mines of Romania. The project, funded by PHARE, started with a critical analysis of the maintenance and repair systems of equipment in both the open-pit and underground mines operated by RALO (Regia Autonoma a Lignitului Octenia). This study paved the way for the introduction of a computerised maintenance system and the inception of a planned preventative maintenance scheme. A development strategy leading by a structural methodology towards predictive maintenance and total productive maintenance was drawn up and attention was given to multi-skilling, training and further facilitating activities to enable the success of the total productive maintenance strategy. An abridged version of the paper was presented at MAINTE 97, held in Birmingham, UK in 1997. 5 refs., 5 figs., 1 tab.

  2. Advances in safety related maintenance

    International Nuclear Information System (INIS)

    2000-03-01

    The maintenance of systems, structures and components in nuclear power plants (NPPs) plays an important role in assuring their safe and reliable operation. Worldwide, NPP maintenance managers are seeking to reduce overall maintenance costs while maintaining or improving the levels of safety and reliability. Thus, the issue of NPP maintenance is one of the most challenging aspects of nuclear power generation. There is a direct relation between safety and maintenance. While maintenance alone (apart from modifications) will not make a plant safer than its original design, deficient maintenance may result in either an increased number of transients and challenges to safety systems or reduced reliability and availability of safety systems. The confidence that NPP structures, systems and components will function as designed is ultimately based on programmes which monitor both their reliability and availability to perform their intended safety function. Because of this, approaches to monitor the effectiveness of maintenance are also necessary. An effective maintenance programme ensures that there is a balance between the improvement in component reliability to be achieved and the loss of component function due to maintenance downtime. This implies that the safety level of an NPP should not be adversely affected by maintenance performed during operation. The nuclear industry widely acknowledges the importance of maintenance in NPP safety and operation and therefore devotes great efforts to develop techniques, methods and tools to aid in maintenance planning, follow-up and optimization, and in assuring the effectiveness of maintenance

  3. Performance-based inspection and maintenance strategies

    International Nuclear Information System (INIS)

    Vesely, W.E.

    1995-01-01

    Performance-based inspection and maintenance strategies utilize measures of equipment performance to help guide inspection and maintenance activities. A relevant measure of performance for safety system components is component unavailability. The component unavailability can also be input into a plant risk model such as a Probabilistic Risk Assessment (PRA) to determine the associated plant risk performance. Based on the present and projected unavailability performance, or the present and projected risk performance, the effectiveness of current maintenance activities can be evaluated and this information can be used to plan future maintenance activities. A significant amount of information other than downtimes or failure times is collected or can be collected when an inspection or maintenance is conducted which can be used to estimate the component unavailability. This information generally involves observations on the condition or state of the component or component piecepart. The information can be detailed such as the amount of corrosion buildup or can be general such as the general state of the component described as ' high degradation', ' moderate degradation', or ' low degradation'. Much of the information collected in maintenance logs is qualitative and fuzzy. As part of an NRC Research program on performance-based engineering modeling, approaches have been developed to apply Fuzzy Set Theory to information collected on the state of the component to determine the implied component or component piecepart unavailability. Demonstrations of the applications of Fuzzy Set Theory are presented utilizing information from plant maintenance logs. The demonstrations show the power of Fuzzy Set Theory in translating engineering information to reliability and risk implications

  4. Recent developments towards ITER 2001 divertor maintenance

    International Nuclear Information System (INIS)

    Palmer, J.; Siuko, M.; Agostini, P.; Gottfried, R.; Irving, M.; Martin, E.; Tesini, A.; Uffelen, M. Van

    2005-01-01

    One of the key maintenance operations for the ITER tokamak is the remote replacement of its divertor system. The components making up this system are expected to be activated to a level of several hundred gyrations per hour and contaminated with hazardous and/or activated dust (beryllium, carbon, tungsten) and tritium. A suite of specialized remote handling (RH) equipment is, therefore, necessary to facilitate divertor exchange. This paper describes the ITER divertor maintenance approach together with recent European efforts towards the design and development of the associated remote handling equipment and procedures

  5. Working memory maintenance is sufficient to reduce state anxiety.

    Science.gov (United States)

    Balderston, Nicholas L; Quispe-Escudero, David; Hale, Elizabeth; Davis, Andrew; O'Connell, Katherine; Ernst, Monique; Grillon, Christian

    2016-11-01

    According to the attentional control theory (ACT) proposed by Eysenck and colleagues, anxiety interferes with cognitive processing by prioritizing bottom-up attentional processes over top-down attentional processes, leading to competition for access to limited resources in working memory, particularly the central executive (Eysenck, Derakshan, Santos, & Calvo, ). However, previous research using the n-back working memory task suggests that working memory load also reduces state anxiety. Assuming that similar mechanisms underlie the effect of anxiety on cognition, and the effect of cognition on anxiety, one possible implication of the ACT would suggest that the reduction of state anxiety with increasing working memory load is driven by activation of central executive attentional control processes. We tested this hypothesis using the Sternberg working memory paradigm, where maintenance processes can be isolated from central executive processes (Altamura et al., ; Sternberg, ). Consistent with the n-back results, subjects showed decreased state anxiety during the maintenance period of high-load trials relative to low-load trials, suggesting that maintenance processes alone are sufficient to achieve this state anxiety reduction. Given that the Sternberg task does not require central executive engagement, these results are not consistent with an implication of the ACT where the cognition/anxiety relationship and anxiety/cognition relationship are mediated by similar central executive mechanisms. Instead, we propose an extension of the ACT such that engaging working memory maintenance suppresses state anxiety in a load-dependent manner. Furthermore, we hypothesize that the efficacy of this effect may moderate the effect of trait anxiety on cognition. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  6. Parathyroid Hormone Activates Phospholipase C (PLC)-Independent Protein Kinase C Signaling Pathway via Protein Kinase A (PKA)-Dependent Mechanism: A New Defined Signaling Route Would Induce Alternative Consideration to Previous Conceptions.

    Science.gov (United States)

    Tong, Guojun; Meng, Yue; Hao, Song; Hu, Shaoyu; He, Youhua; Yan, Wenjuan; Yang, Dehong

    2017-04-20

    BACKGROUND Parathyroid hormone (PTH) is an effective anti-osteoporosis agent, after binding to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the major pathway. Earlier studies have reported that PTHR1 might also activate PKC via a PLC-independent mechanism, but this pathway remains unclear. MATERIAL AND METHODS In HEK293 cells, cAMP accumulation was measured with ELISA and PKC was measured with fluorescence resonance energy transfer (FRET) analysis using CKAR plasmid. In MC3T3-E1 cells, real-time PCR was performed to examine gene expressions. Then assays for cell apoptosis, cell differentiation, alkaline phosphatase activity, and mineralization were performed. RESULTS The FRET analysis found that PTH(1-34), [G1,R19]PTH(1-34) (GR(1-34), and [G1,R19]PTH(1-28) (GR(1-28) were all activated by PKC. The PKC activation ability of GR(1-28) was blocked by cAMP inhibitor (Rp-cAMP) and rescued with the addition of active PKA-α and PKA-β. The PKC activation ability of GR(1-34) was partially inhibited by Rp-cAMP. In MC3T3-E1 cells, gene expressions of ALP, CITED1, NR4a2, and OSX that was regulated by GR(1-28) were significantly changed by the pan-PKC inhibitor Go6983. After pretreatment with Rp-cAMP, the gene expressions of ALP, CITED1, and OPG were differentially regulated by GR(1-28) or GR(1-34), and the difference was blunted by Go6983. PTH(1-34), GR(1-28), and GR(1-34) significantly decreased early apoptosis and augmented osteoblastic differentiation in accordance with the activities of PKA and PKC. CONCLUSIONS PLC-independent PKC activation induced by PTH could be divided into two potential mechanisms: one was PKA-dependent and associated with PTH(1-28); the other was PKA-independent and associated with PTH(29-34). We also found that PTH could activate PLC-independent PKC via PKA-dependent mechanisms.

  7. Interval of Routine Maintenance and Maintenance Performance: A Literature Review

    Directory of Open Access Journals (Sweden)

    Au-Yong Cheong Peng

    2016-01-01

    Full Text Available In high-rise residential buildings, the quality of facilities management services is significant to the normal operation of the facilities. Unfortunately, lack of concern towards building maintenance, especially preventive maintenance, happens in domestic housing industry in Malaysia. Majority of the maintenance operations of condominiums suffer from lack of planning, lack of proactive maintenance plan, and lack of proper implementation. Thus, this paper reviews the implementation of preventive maintenance strategy, routine maintenance in specific. An extensive review of literature published in 1987 to 2014 is performed for the purpose of this research. The publications are sourced from journal articles, conference proceedings and books. The literature analysis confirms that the routine maintenance of facilities and building services is vital and it can be influential towards the maintenance performance. Subsequently, a theoretical framework is developed, which shows the relationship between routine maintenance of building facilities & services and maintenance performance. The building facilities & services are divided into two categories. They are essential facilities & services that ensure the safety, health, habitability, and operability of buildings; while value-added facilities & services deal with property value, return on investment, and quality living of buildings. Based on the findings, a future research is proposed, which aims to identify the appropriate routine of maintenance for the facilities and services in high-rise residential buildings to improve the maintenance performance.

  8. Selection of maintenance tasks

    International Nuclear Information System (INIS)

    Dean, B.; Rombos, P.

    1995-10-01

    Two methodologies for maintenance task selection, Reliability Centre Maintenance (RCM) and Degradation Mode Analysis (DMA), are compared with regard to application in the nuclear industry and potential for application at CANDU nuclear power plants. RCM is the favoured one of the two methodologies. It is more thorough than DMA, is well supported within the US nuclear industry, and - with experience in application - is gaining cost effectiveness. There is interest in the use of RCM in other nations, including France and Japan, and it is already being implemented at Bruce A NGS and Bruce B NGS in Canada. DMA lags behind RCM in development and currently there is little experience to support claims of major benefits at reduced cost. Significant advantages over RCM need to be demonstrated if DMA is to gain acceptance in the nuclear industry. (author). 41 refs., 7 tabs., 8 figs

  9. A study on autonomous maintenance robot, 7

    International Nuclear Information System (INIS)

    Fukuda, Toshio; Hosokai, Hidemi; Shimasaka, Naoki; Kaneshige, Masanori; Iwasaki, Shinnosuke.

    1990-01-01

    This paper deals with the new mechanism of a new maintenance robot, Mark IV, following the previous reports on pipeline inspection and maintenance robots of Mark I, II, and III. The Mark IV has a mechanism capable of inspecting surfaces of storage tanks as well as pipeline outer surfaces, which is another capability of the maintenance robots, different from the previous ones. The main features of Mark IV are as follows, (i) The robot has a multijoint structure, so that it has better adaptability to the curvartures of pipelines and storage tanks. (ii) The joint of the robot has SMA actuators to make the robot lighter in weight. Some actuator shape characteristics are also examined for the robot structure and control. (iii) The robot has suckers at both ends so that the robot can climb up along the wall from the ground. (iv) A robot with the inch worm mechanisms has many functional motions, such that it can pass over flanges and T-joints, and transfer to adjacent pipelines with a wider range of pipe diameters. (v) A control method is given for the mobile motion control. Thus, the functional level of the maintenance robot has been greatly improved by the introduction of the Mark IV robot. (author)

  10. Computerized plant maintenance management

    International Nuclear Information System (INIS)

    Kozusko, A.M.

    1986-01-01

    The evolution of the computer has and continues to have a great impact on industry. We are in an adjustment cycle with the current computer evolution, and will need to adapt to make the changes for the coming decade. Hardware and software are continually being enhanced. Computers are becoming more powerful and will eventually provide an effective man-machine interface. This paper shares experiences encountered during implementations of computerized maintenance systems

  11. Preventive maintenance study : interim report.

    Science.gov (United States)

    2017-09-01

    This interim report details the performance of 69 test sites treated with various preventive maintenance treatments. The maintenance treatments applied included crack sealing, full lane chip sealing, wheel path chip sealing, dig outs (mill and fill),...

  12. Data management in maintenance outsourcing

    International Nuclear Information System (INIS)

    Murthy, D.N.P.; Karim, M.R.; Ahmadi, A.

    2015-01-01

    Most businesses view maintenance as tasks carried out by technicians and the data collected is mostly cost related. There is a growing trend towards outsourcing of maintenance and the data collection issues are not addressed properly in most maintenance service contracts. Effective maintenance management requires proper data management - data collection and analysis for decision-making. This requires a proper framework and when maintenance is outsourced it raises several issues and challenges. The paper develops a framework for data management when maintenance is outsourced and looks at a real case study that highlights the need for proper data management. - Highlights: • Framework for data management in maintenance outsourcing. • Black-box to grey-box approaches for modelling. • Improvements to maintenance decision-making. • Case study to illustrate the approaches and the shortcomings in data collection

  13. Living Well with Diabetes: a randomized controlled trial of a telephone-delivered intervention for maintenance of weight loss, physical activity and glycaemic control in adults with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Eakin Elizabeth G

    2010-08-01

    Full Text Available Abstract Background By 2025, it is estimated that approximately 1.8 million Australian adults (approximately 8.4% of the adult population will have diabetes, with the majority having type 2 diabetes. Weight management via improved physical activity and diet is the cornerstone of type 2 diabetes management. However, the majority of weight loss trials in diabetes have evaluated short-term, intensive clinic-based interventions that, while producing short-term outcomes, have failed to address issues of maintenance and broad population reach. Telephone-delivered interventions have the potential to address these gaps. Methods/Design Using a two-arm randomised controlled design, this study will evaluate an 18-month, telephone-delivered, behavioural weight loss intervention focussing on physical activity, diet and behavioural therapy, versus usual care, with follow-up at 24 months. Three-hundred adult participants, aged 20-75 years, with type 2 diabetes, will be recruited from 10 general practices via electronic medical records search. The Social-Cognitive Theory driven intervention involves a six-month intensive phase (4 weekly calls and 11 fortnightly calls and a 12-month maintenance phase (one call per month. Primary outcomes, assessed at 6, 18 and 24 months, are: weight loss, physical activity, and glycaemic control (HbA1c, with weight loss and physical activity also measured at 12 months. Incremental cost-effectiveness will also be examined. Study recruitment began in February 2009, with final data collection expected by February 2013. Discussion This is the first study to evaluate the telephone as the primary method of delivering a behavioural weight loss intervention in type 2 diabetes. The evaluation of maintenance outcomes (6 months following the end of intervention, the use of accelerometers to objectively measure physical activity, and the inclusion of a cost-effectiveness analysis will advance the science of broad reach approaches to weight

  14. Maintenance in dental implants

    Directory of Open Access Journals (Sweden)

    Giselle Póvoa Gomes

    2008-01-01

    Full Text Available In implants, maintenance is a decisive factor for obtaining success when implant supported overdentures and dentures are used. The present stud presents, a clinical case of a patient, a 70 year-old white man, with a completely edentulous mandibular alveolar ridge, severe bone resorption with presence of basal bone only, and absence of vestibule. Initially, treatment consisted of the placement of a mandibular overdenture, supported on three implants in the anterior inter-foramen region, as the left implant was transfixed in the basal bone of 2 to 3 millimeters. Eleven years later, another two implants were placed in the anterior area and an immediate load was performed up to the first molars, for the placement of an implant supported fixed. Throughout the entire treatment, meticulous maintenance was carried out, with follow-up for fourteen years, interrupted by the patient’s death. From the third month after the opening the three implants initially placed, the presence of keratinized mucosa, definition of the vestibule, maturation of the alveolar ridge and bone formation in the mento region were observed. It was concluded that good planning, allied to mastery of the technique and adequate maintenance were the prerequisites necessary for obtaining favorable results, success of the present case, and for the patient to have a better quality of life.

  15. [Promoting a balanced diet and physical activity among children : Conditions for the successful implementation and maintenance of multi-level interventions and policies: Results of two qualitative case studies].

    Science.gov (United States)

    Steenbock, Berit; Muellmann, Saskia; Zeeb, Hajo; Pischke, Claudia R

    2017-10-01

    To date, conditions for successfully implementing and maintaining multi-level interventions and policies for the promotion of a balanced diet and physical activity are not well understood from the perspective of stakeholders. The aim of this article is to examine which factors are regarded as facilitating or impeding introduction, implementation and maintenance of multi-level interventions and policies from the standpoint of stakeholders. Semi-structured face-to-face interviews with stakeholders of one multi-level intervention (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS [IDEFICS] for the prevention of childhood obesity, n = 4) and one policy (Federal state offices coordinating networks for the provision of healthy food options in schools, n = 3) were analysed using qualitative content analysis. In both cases, the use of existing structures facilitated introduction, implementation and maintenance. Additionally, training of staff for implementation according to standardised protocols or concepts and taking structures and work conditions of settings into account during implementation were considered essential. In both cases, conflicting interests in interdisciplinary stakeholder teams regarding intervention content and implementation were identified as a barrier. A lack of political support and insecure long-term funding only played a role in regard to the implementation and maintenance of policies. On the other hand, target groups of the multi-level intervention were not sufficiently involved in the development of intervention materials which resulted in a lack of tailoring and acceptance in the target groups. The results provide important insights into the long-term implementation of multi-level interventions and policies in different settings.

  16. Proactive maintenance initiatives at Argonne National Laboratory-West

    International Nuclear Information System (INIS)

    Duckwitz, N.R.; Duncan, L.W.; Whipple, J.J.

    1995-01-01

    In the late 1980's, ANL-W Management foresaw a need to provide dedicated technical support for maintenance supervisors. Maintenance supervisors were facing increased challenges to ensure all environmental, safety, and waste management regulations were followed in daily maintenance activities. This increased burden was diverting supervisory time away from on-the-job supervision. Supervisors were finding less time for their ''mentor'' roles to ensure maintenance focused on finding and correcting root causes. Additionally the traditional maintenance organization could not keep up with the explosion in predictive maintenance technologies. As a result, engineers were tasked to provide direct technical support to the maintenance organization. Today the maintenance technical support group consists of two mechanical engineers, two electrical engineers and an I ampersand C engineer. The group provides a readily available, quick response resource for crafts people and their supervisors. They can and frequently do ask the support group for help to determine the root cause and to effect permanent fixes. Crafts and engineers work together informally to make an effective maintenance team. In addition to day-to-day problem solving, the technical support group has established several maintenance improvement programs for the site. This includes vibration analysis of rotating machinery, testing of fuel for emergency diesel generators, improving techniques for testing of high efficiency particulate air (HEPA) filters, and capacity testing of UPS and emergency diesel starting batteries. These programs have increased equipment reliability, reduced conventional routine maintenance, reduced unexpected maintenance, and improved testing accuracy. This paper will discuss the interaction of the technical support group within the maintenance department. Additionally the maintenance improvement programs will be presented along with actual cases encountered, the resolutions and lessons learned

  17. AUTOMOTIVE DIESEL MAINTENANCE. PROGRAM OUTLINE.

    Science.gov (United States)

    Human Engineering Inst., Cleveland, OH.

    INFORMATIONAL TOPICS COVERED IN THE TEXT MATERIALS AND SELF-INSTRUCTIONAL BRANCH PROGRAMED TRAINING FILMS FOR A 2-YEAR, 55 MODULE PROGRAM IN AUTOMOTIVE DIESEL MAINTENANCE ARE GIVEN. THE 30 MODULES FOR "AUTOMOTIVE DIESEL MAINTENANCE 1" ARE AVAILABLE AS VT 005 655 - VT 005 684, AND THE 25 MODULES FOR "AUTOMOTIVE DIESEL MAINTENANCE 2" ARE AVAILABLE…

  18. The ITER remote maintenance system

    International Nuclear Information System (INIS)

    Tesini, A.

    2007-01-01

    Full text of publication follows: ITER is a joint international research and development project that aims to demonstrate the scientific and technological feasibility of fusion power. As soon as the plasma operation begins using tritium, the replacement of the vacuum vessel internal components will need to be done with remote handling techniques. To accomplish these operations ITER has equipped itself with a Remote Maintenance System; this includes the Remote Handling equipment set and the Hot Cell facility. Both need to work in a cooperative way, with the aim of minimizing the machine shutdown periods and to maximize the machine availability. The ITER Remote Handling equipment set is required to be available, robust, reliable and retrievable. The machine components, to be remotely handle-able, are required to be designed simply so as to ease their maintenance. The baseline ITER Remote Handling equipment is described. The ITER Hot Cell Facility is required to provide a controlled and shielded area for the execution of repair operations (carried out using dedicated remote handling equipment) on those activated components which need to be returned to service, inside the vacuum vessel. The Hot Cell provides also the equipment and space for the processing and temporary storage of the operational and decommissioning rad-waste. A conceptual ITER Hot Cell Facility is described. (authors)

  19. The ITER remote maintenance system

    International Nuclear Information System (INIS)

    Tesini, A.; Palmer, J.

    2007-01-01

    ITER is a joint international research and development project that aims to demonstrate the scientific and technological feasibility of fusion power. As soon as the plasma operation begins using tritium, the replacement of the vacuum vessel internal components will need to be done with remote handling techniques. To accomplish these operations ITER has equipped itself with a Remote Maintenance System; this includes the Remote Handling equipment set and the Hot Cell facility. Both need to work in a cooperative way, with the aim of minimizing the machine shutdown periods and to maximize the machine availability. The ITER Remote Handling equipment set is required to be available, robust, reliable and retrievable. The machine components, to be remotely handle-able, are required to be designed simply so as to ease their maintenance. The baseline ITER Remote Handling equipment is described. The ITER Hot Cell Facility is required to provide a controlled and shielded area for the execution of repair operations (carried out using dedicated remote handling equipment) on those activated components which need to be returned to service, inside the vacuum vessel. The Hot Cell provides also the equipment and space for the processing and temporary storage of the operational and decommissioning radwaste. A conceptual ITER Hot Cell Facility is described. (orig.)

  20. Augmented reality application utility for aviation maintenance work instruction

    Science.gov (United States)

    Pourcho, John Bryan

    Current aviation maintenance work instructions do not display information effectively enough to prevent costly errors and safety concerns. Aircraft are complex assemblies of highly interrelated components that confound troubleshooting and can make the maintenance procedure difficult (Drury & Gramopadhye, 2001). The sophisticated nature of aircraft maintenance necessitates a revolutionized training intervention for aviation maintenance technicians (United States General Accounting Office, 2003). Quite simply, the paper based job task cards fall short of offering rapid access to technical data and the system or component visualization necessary for working on complex integrated aircraft systems. Possible solutions to this problem include upgraded standards for paper based task cards and the use of integrated 3D product definition used on various mobile platforms (Ropp, Thomas, Lee, Broyles, Lewin, Andreychek, & Nicol, 2013). Previous studies have shown that incorporation of 3D graphics in work instructions allow the user to more efficiently and accurately interpret maintenance information (Jackson & Batstone, 2008). For aircraft maintenance workers, the use of mobile 3D model-based task cards could make current paper task card standards obsolete with their ability to deliver relevant, synchronized information to and from the hangar. Unlike previous versions of 3D model-based definition task cards and paper task cards, which are currently used in the maintenance industry, 3D model based definition task cards have the potential to be more mobile and accessible. Utilizing augmented reality applications on mobile devices to seamlessly deliver 3D product definition on mobile devices could increase the efficiency, accuracy, and reduce the mental workload for technicians when performing maintenance tasks (Macchiarella, 2004). This proposal will serve as a literary review of the aviation maintenance industry, the spatial ability of maintenance technicians, and benefits of

  1. A process for risk-focused maintenance

    International Nuclear Information System (INIS)

    Lofgren, E.V.; Cooper, S.E.; Kurth, R.E.; Phillips, L.B.

    1991-03-01

    This report presents a process for focusing maintenance resources on components that enable nuclear plant systems to perform their essential functions and on components whose failure may initiate challenges to safety systems, so as to have the greatest impact in decreasing risk. The process provides criteria, based on risk, for deciding which components are critical to risk and determining what maintenance activities are required to ensure reliable operation of those risk-critical components. Two approaches are provided for selection of risk-critical components. One approach uses the results of a Probabilistic Risk Assessment (PRA); the other is based on the methodology developed for this report, which has a basis in PRA although it does not use the results of a PRA study. Following identification of risk-critical components, both approaches use a single methodology for determining what maintenance activities are required to ensure reliable operation of the identified components. The report also provides demonstrations of application of the two approaches to selection of risk-critical components and demonstrations of application of the methodology for determining what maintenance activities are required to an active standby safety system, a normally operating system, and passive components. 5 refs., 11 figs., 1 tab

  2. Factory Downtime Minimization through Tracking of Maintenance ...

    African Journals Online (AJOL)

    The front factory comprises two tandems: tandem A and B. The total downtime records for the first six months of 2013/14 sugar production season for tandem A show that the downtime was mainly due to mechanical failures, lack of canes, preventive maintenance activities, cleanings due to blockages, and electrical failures, ...

  3. Teaching Guide for Building Maintenance Occupations.

    Science.gov (United States)

    Kempton, Robert F.

    This teaching guide for building maintenance is one of a series of five performance- and employer-based secondary level vocational education guides. Part 1 provides tools, resources, and a process to be used at the local level to develop a training curriculum and supporting instructional activities. It includes a comprehensive overview of the…

  4. Preventive maintenance for computer systems - concepts & issues ...

    African Journals Online (AJOL)

    Performing preventive maintenance activities for the computer is not optional. The computer is a sensitive and delicate device that needs adequate time and attention to make it work properly. In this paper, the concept and issues on how to prolong the life span of the system, that is, the way to make the system last long and ...

  5. Maintenance optimization plan for essential equipment reliability

    International Nuclear Information System (INIS)

    Steffen, D.H.

    1996-02-01

    The Maintenance Optimization Plan (MOP) for Essential Equipment Reliability will furnish Tank Waste Remediation System (TWRS) management with a pro-active, forward-thinking process for maintaining essential structures, systems, and components (ESSC) at the Hanford Site tank farms in their designed condition, and to ensure optimum ESSC availability and reliability

  6. Regulatory surveillance of safety related maintenance at nuclear power plants. Report of a technical committee meeting

    International Nuclear Information System (INIS)

    1997-08-01

    The operational safety and reliability of a nuclear power plant as well as its availability for electricity generation depend on, among other things, its maintenance programme. Regulatory bodies therefore have considerable interest in maintenance activities. There are several approaches to maintenance, i.e. reliability centered maintenance or risk focused maintenance, aimed at optimizing maintenance by focusing on important components or systems. These approaches may result in significant changes to maintenance activities and therefore have to be considered for regulatory acceptance. In order to review and discuss the status of maintenance regulation in participating countries, the IAEA convened a Technical Committee Meeting on Regulatory Oversight of Maintenance Activities at Nuclear Power Plants in Vienna from 9 to 13 October 1995. The meeting was attended by 16 experts from 11 countries. In addition to the consideration of papers that were presented and which are reproduced here, extensive group and panel discussions took place during the meeting. These covered three main topics: general features and basic characteristics of maintenance regulation, regulatory acceptance of maintenance optimization and use of PSA for maintenance optimization. The discussion are summarized in Section 2. Section 3 discusses the following three additional topics: regulatory involvement in the maintenance programme, modifications to the maintenance programme and personnel related aspects of maintenance. The conclusions are presented in Section 4. Figs, tabs

  7. Hyperalgesic priming (type II) induced by repeated opioid exposure: maintenance mechanisms.

    Science.gov (United States)

    Araldi, Dioneia; Ferrari, Luiz F; Levine, Jon D

    2017-07-01

    We previously developed a model of opioid-induced neuroplasticity in the peripheral terminal of the nociceptor that could contribute to opioid-induced hyperalgesia, type II hyperalgesic priming. Repeated administration of mu-opioid receptor (MOR) agonists, such as DAMGO, at the peripheral terminal of the nociceptor, induces long-lasting plasticity expressed, prototypically as opioid-induced hyperalgesia and prolongation of prostaglandin E2-induced hyperalgesia. In this study, we evaluated the mechanisms involved in the maintenance of type II priming. Opioid receptor antagonist, naloxone, induced hyperalgesia in DAMGO-primed paws. When repeatedly injected, naloxone-induced hyperalgesia, and hyperalgesic priming, supporting the suggestion that maintenance of priming involves changes in MOR signaling. However, the knockdown of MOR with oligodeoxynucleotide antisense did not reverse priming. Mitogen-activated protein kinase and focal adhesion kinase, which are involved in the Src signaling pathway, previously implicated in type II priming, also inhibited the expression, but not maintenance of priming. However, when Src and mitogen-activated protein kinase inhibitors were coadministered, type II priming was reversed, in male rats. A second model of priming, latent sensitization, induced by complete Freund's adjuvant was also reversed, in males. In females, the inhibitor combination was only able to inhibit the expression and maintenance of DAMGO-induced priming when knockdown of G-protein-coupled estrogen receptor 30 (GPR30) in the nociceptor was performed. These findings demonstrate that the maintenance of DAMGO-induced type II priming, and latent sensitization is mediated by an interaction between, Src and MAP kinases, which in females is GPR30 dependent.

  8. Maintenance of BWR control rod drive mechanisms

    International Nuclear Information System (INIS)

    Greene, R.H.

    1991-01-01

    Control rod drive mechanism (CRDM) replacement and rebuilding is one of the highest dose, most physically demanding, and complicated maintenance activities routinely accomplished by BWR utilities. A recent industry workshop sponsored by the Oak Ridge National Laboratory, which dealt with the effects of CRDM aging, revealed enhancements in maintenance techniques and tooling which have reduced ALARA, improved worker comfort and productivity, and have provided revised guidelines for CRDM changeout selection. Highlights of this workshop and ongoing research on CRDM aging are presented in this paper

  9. Transfer of technology in maintenance tools

    International Nuclear Information System (INIS)

    Delorme, H.; Cartry, J.P.

    1985-10-01

    For maximum reliability of maintenance operations, FRAMATOME has aimed to improve the accessibility of highly irradiated and contaminated reactor coolant system equipment by the active promotion of an automation and robotization strategy. A number of robot designs have been developed providing replacement of operators inside the steam generator channel head, smooth handling of heavy or cumbersome objects in this zone, easy marking of steam generator tubes and increased speed of repetitive channel head operations: maintenance spider, theta-theta prime robotic service arm, R-theta robotic service arm, remote manipulator arm. Two operations are described: channel head folding cover plate and, operation of the torquing machine for head cover plate

  10. Is physical activity maintenance from adolescence to young adulthood associated with reduced CVD risk factors, improved mental health and satisfaction with life: the HUNT Study, Norway.

    Science.gov (United States)

    Rangul, Vegar; Bauman, Adrian; Holmen, Turid Lingaas; Midthjell, Kristian

    2012-12-14

    Little is known about the effect maintaining physical activity throughout adolescence has on cardiovascular risk factors and health status in early adulthood. This ten-year prospective longitudinal study investigated whether differences in physical activity patterns from adolescence to young-adulthood showed different associations with subsequent cardio-metabolic risk factors and mental health in young-adulthood. Based on the second and third Norwegian Nord-Trøndelag Health Surveys (HUNT2 and 3), we included 1869 individuals (838 males) participating in Young-HUNT (1995-97), aged 13-19 years and followed-up at HUNT3 (2006-08), aged 23-31. Self-reported physical activity (PA), mental health and perceived health were recorded, along with measurements of body mass index (BMI), waist circumference (WC), total cholesterol (TC), HDL cholesterol, glucose, triglycerides, resting heart rate (HR) and blood pressure. We used separate linear regressions models to investigate associations between physical activity and each CVD risk factor, and logistic regression analysis to examine PA patterns and subsequent mental health. Physically active maintainers were compared to inactive maintainers. Adopters (inactive as adolescents and physically active as young adults) were compared to inactive maintainers and to those who discontinued activity (relapsers). Active maintainers had significantly lower HR, compared to all other PA patterns. Active maintaining men had significantly lower WC than relapsers and inactive maintainers. When adjusted for age and gender, WC, BMI, HR, diastolic blood pressure and HDL-C showed significant differences comparing active maintaining to other PA patterns. Comparing inactive maintainers against adopters, only HR was significantly lower. Male adopters did not differ significantly in CVD risk compared to inactive maintainers and relapsers. Among females adopting was associated with lower HR and TC compared to inactive maintainers. Active maintainers

  11. Machine Maintenance Scheduling with Reliability Engineering Method and Maintenance Value Stream Mapping

    Science.gov (United States)

    Sembiring, N.; Nasution, A. H.

    2018-02-01

    Corrective maintenance i.e replacing or repairing the machine component after machine break down always done in a manufacturing company. It causes the production process must be stopped. Production time will decrease due to the maintenance team must replace or repair the damage machine component. This paper proposes a preventive maintenance’s schedule for a critical component of a critical machine of an crude palm oil and kernel company due to increase maintenance efficiency. The Reliability Engineering & Maintenance Value Stream Mapping is used as a method and a tool to analize the reliability of the component and reduce the wastage in any process by segregating value added and non value added activities.

  12. Safety related maintenance in the framework of the reliability centered maintenance concept

    International Nuclear Information System (INIS)

    1992-07-01

    Elevated safety requirements and ever increasing costs of maintenance of nuclear power plants stimulate the interest in different methods and approaches to optimize maintenance activities. Among different concepts, the Reliability Centered Maintenance (RCM) as an approach to improve Preventive Maintenance (PM) programmes is being widely discussed an applied in several IAEA Member States. In order to summarize basic principles and current implementation of the RCM, the IAEA organized a Consultants Meeting in November 1990. The report prepared during that meeting was discussed during the Technical Committee Meeting (TCM) held in May 1991. Numerous technical presentations as well as panel and plenary discussions took place at the TCM. This document contains the report of the Consultants Meeting (modified to include comments of the TCM), a summary of the most important discussions as well as all 14 papers presented at the TCM

  13. Health problems and help-seeking activities of methadone maintenance clients at Auckland Methadone Service (AMS): potential for community pharmacy service expansion?

    Science.gov (United States)

    Sheridan, Janie; Wheeler, Amanda; Walters, Carina

    2005-01-01

    Background In general the health of methadone clients has been found to be poorer than that of the general population. In New Zealand specialist drug services are not funded to provide primary healthcare services. Many health conditions could potentially be managed by community pharmacists who have frequent contact with this client group. This study sought to explore the health problems suffered by methadone clients, who they sought help from, and the potential for greater involvement of pharmacists. Methods Self-completion questionnaire of methadone maintenance clients managed in specialist care in Auckland, New Zealand. Results The most common health problem experienced by these clients in the past three months was sweating (70.0%), and more than half of the respondents also reported experiencing headache, fatigue and depression. The least frequently experienced conditions were hay fever (12.9%) and abscesses (12.1%). Respondents indicated that the top three choices from whom they would seek help were GP (56.7%), the client's partner (31.6%) and community pharmacists (27.9%). Barriers to seeking help from pharmacists included issues around cost, perceptions of pharmacist knowledge and skills, privacy and confidentiality. Conclusion Methadone clients in this study indicated that they suffered a number of general health problems, and in many cases were likely to seek help from a GP or their own partner, before seeking help from pharmacists. However, for over one quarter of respondents the pharmacist was in the top three from whom they would seek advice. Any barriers towards consulting pharmacists, in the main seem to be resolvable. PMID:16283944

  14. Preventive maintenance: optimization of time - based discard decisions at the bruce nuclear generating station

    International Nuclear Information System (INIS)

    Doyle, E.K.; Jardine, A.K.S.

    2001-01-01

    The use of various maintenance optimization techniques at Bruce has lead to cost effective preventive maintenance applications for complex systems. As previously reported at ICONE 6 in New Orleans, 1996, several innovative practices reduced Reliability Centered Maintenance costs while maintaining the accuracy of the analysis. The optimization strategy has undergone further evolution and at the present an Integrated Maintenance Program (IMP) is in place where an Expert Panel consisting of all players/experts proceed through each system in a disciplined fashion and reach agreement on all items under a rigorous time frame. It is well known that there are essentially 3 maintenance based actions that can flow from a Maintenance Optimization Analysis: condition based maintenance, time based maintenance and time based discard. The present effort deals with time based discard decisions. Maintenance data from the Remote On-Power Fuel Changing System was used. (author)

  15. Motorway maintenance work

    CERN Document Server

    2005-01-01

    Built 20 years ago, the airport section of the Geneva motorway bypass is now in need of maintenance work and alterations to bring it into line with the new standards. Two-lane traffic will be maintained in both directions during the work, which will be carried out in 2006 and 2007, but there will be various temporary special traffic arrangements in force. We should like to thank you in advance for your understanding. Civil Engineering Department, DAEL, State of Geneva More information: tel. 163 or www.autoroute-aeroport.ch Fewer cars, fewer traffic jams, with www.covoiturage.ch

  16. Managing and controlling maintenance

    International Nuclear Information System (INIS)

    Chavez, G.; Perla, H.F.

    1980-01-01

    A well-planned maintenance-management program can bring organized yet flexible scheduling, improved productivity, and a ready-access data bank. The system detailed in the article, developed for a nuclear power plant, has application to any equipment-intensive facility. Key features of the system include: documentation of all work requirements and their completion; automated prioritizing of work orders; automatic generation of work orders for repetitive work, when due; work lists in priority sequence; deferred, standby, and outage work reports; labor and work-order backlog information; equipment work histories and cumulative failure data

  17. Field installation and maintenance

    International Nuclear Information System (INIS)

    Prebble, R.E.

    1981-01-01

    The use of a neutron moisture meter for the determination of the water content of soil necessitates the installation of an access tube down which the probe can be lowered. Errors in neutron count rate will be introduced if water enters the air gap between a loose fitting tube and the soil. Errors may also be caused by changes in the soil structure resulting from the techniques for soil removal and from driving the access hole. Access tube materials and dimensions, methods of installation and maintenance of the site are discussed

  18. Knowledge representation for integrated plant operation and maintenance

    DEFF Research Database (Denmark)

    Lind, Morten

    2010-01-01

    Integrated operation and maintenance of process plants has many advantages. One advantage is the improved economy obtained by reducing the number of plant shutdowns. Another is to increase reliability of operation by monitoring of risk levels during on-line maintenance. Integrated plant operation...... and maintenance require knowledge bases which can capture the interactions between the two plant activities. As an example, taking out a component or a subsystem for maintenance during operation will require a knowledge base representing the interactions between plant structure, functions, operating states...

  19. Predictive Maintenance (PdM) Centralization for Significant Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Dale

    2010-09-15

    Cost effective predictive maintenance (PdM) technologies and basic energy calculations can mine energy savings form processes or maintenance activities. Centralizing and packaging this information correctly empowers facility maintenance and reliability professionals to build financial justification and support for strategies and personnel to weather global economic downturns and competition. Attendees will learn how to: Systematically build a 'pilot project' for applying PdM and tracking systems; Break down a typical electrical bill to calculate energy savings; Use return on investment (ROI) calculations to identify the best and highest value options, strategies and tips for substantiating your energy reduction maintenance strategies.

  20. ITER layout: Alternatives for improved maintenance

    International Nuclear Information System (INIS)

    Blevins, J.; Barnes, C.; Maisonnier, D.

    1991-01-01

    International Thermonuclear Experimental Reactor maintenance mission objectives and their effect on systems layout are reviewed through the example of the torus vacuum pumping system. Applying maintenance requirements to this system has resulted in significant improvements in component accessibility. Further changes currently under review could result in a reduction in vacuum duct length, the addition of duct shielding to reduce neutron activation, a pump and valve assembly which can be serviced from the floor rather than solely from a crane, and provision for transport casks to enter the pump room through an equipment airlock, large enough to permit the entry of robotic devices as well as construction equipment. This rearrangement could offer savings in overall height of the pump and valve assembly. An innovation in valve configuration will allow for one-line removal of the large vacuum valve seal discs without loss of vacuum. This has potential for reduced maintenance outage time and operating cost. (orig.)

  1. Guidance for UMTRA project surveillance and maintenance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-01-01

    The Guidance for UMTRA Project Surveillance and Maintenance describes the procedures that will be used to verify that Uranium Mill Tailings Remedial Action (UMTRA) Project disposal sites continue to function as designed. The approach of this guidance document is to identify surveillance requirements and maintenance procedures that will be used to comply with NRC license requirements. This document addresses five primary activities: Definition and characterization of final site conditions. Site inspections; Ground-water monitoring; Aerial photography; and Custodial maintenance and contingency repair. Final site conditions will be defined and characterized prior to the completion of remedial actions at a site. As-built drawings will be compiled, a final topographic survey will be performed, a vicinity map will be prepared, and ground and aerial photographs will be taken. Survey monuments, site markers, and signs will be established as will a network of monitoring wells.

  2. Integrated services and maintenance in nuclear power plants

    International Nuclear Information System (INIS)

    Roos, Georg

    2001-01-01

    The general situation concerning services and nuclear power maintenance is reviewed following liberalization of Europa's power market. Issues relating to outsourcing maintenance services, effectiveness and reducing cost structure of maintenance are addressed on the cases of power markets in northern countries, Spain, Switzerland, Germany and Hungary. A special attention is paid on range of maintenance activity offered and performanced by Framatome. Ways of reducing costs in the field of maintenance as well as of reducing outage time are indicated. In conclusion, the following items are emphasized: - liberalization of Europe's power market in eastern Europe at its beginning; - in-house service in eastern Europe with numerous personnel; - Framatome ANP covers the entire range of maintenance competence; - consultance can be the first approach for a common co-operation

  3. Placental complications after a previous cesarean section

    OpenAIRE

    Milošević Jelena; Lilić Vekoslav; Tasić Marija; Radović-Janošević Dragana; Stefanović Milan; Antić Vladimir

    2009-01-01

    Introduction The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complic...

  4. Waste sampling and characterization facility (WSCF) maintenance implementation plan

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, J.L.

    1997-08-13

    This Maintenance Implementation Plan (MIP) is written to satisfy the requirements of the US Department of Energy (DOE) Order 4330.4B, Maintenance Management Program that specifies the general policy and objectives for the establishment of the DOE controlled maintenance programs. These programs provide for the management and performance of cost effective maintenance and repair of the DOE property, which includes facilities. This document outlines maintenance activities associated with the facilities operated by Waste Management Hanford, Inc. (WMH). The objective of this MIP is to provide baseline information for the control and execution of WMH Facility Maintenance activities relative to the requirements of Order 4330.4B, assessment of the WMH maintenance programs, and actions necessary to maintain compliance with the Order. Section 2.0 summarizes the history, mission and description of the WMH facilities. Section 3.0 describes maintenance scope and requirements, and outlines the overall strategy for implementing the maintenance program. Specific elements of DOE Order 4330.4B are addressed in Section 4.0, listing the objective of each element, a discussion of the WMH compliance methodology, and current implementation requirements with references to WMH and HNF policies and procedures. Section 5.0 addresses deviations from policy requirements, and Section 6.0 is a schedule for specific improvements in support of this MIP.

  5. The divertor remote maintenance project

    International Nuclear Information System (INIS)

    Maisonnier, D.; Martin, E.; Akou, K.

    2001-01-01

    Remote replacement of the ITER divertor will be required several times during the life of ITER. To facilitate its regular exchange, the divertor is assembled in the ITER vacuum vessel from 60 cassettes. Radial movers transport each cassette along radial rails through the handling ports and into the vessel where a toroidal mover lifts and transports the cassette around a pair of toroidal rails. Once at its final position the cassette is locked to the toroidal rails and is accurately aligned in both poloidal and toroidal directions. A further requirement on the divertor is to minimise the amount of activated waste to be sent to a repository. To this end the cassettes have been designed to allow the remote replacement, in a hot cell, of their plasma facing components. The paper describes the two facilities built at ENEA Brasimone, Italy, whose aim is to demonstrate the reliable remote maintenance of the divertor cassettes. (author)

  6. The divertor remote maintenance project

    International Nuclear Information System (INIS)

    Maisonnier, D.; Martin, E.; Akou, K.

    1999-01-01

    Remote replacement of the ITER divertor will be required several times during the life of ITER. To facilitate its regular exchange, the divertor is assembled in the ITER vacuum vessel from 60 cassettes. Radial movers transport each cassette along radial rails through the handling ports and into the vessel where a toroidal mover lifts and transports the cassette around a pair of toroidal rails. Once at its final position the cassette is locked to the toroidal rails and is accurately aligned in both poloidal and toroidal directions. A further requirement on the divertor is to minimise the amount of activated waste to be sent to a repository. To this end the cassettes have been designed to allow the remote replacement, in a hot cell, of their plasma facing components. The paper describes the two facilities built at ENEA Brasimone, Italy, whose aim is to demonstrate the reliable remote maintenance of the divertor cassettes. (author)

  7. Maintenance and management system

    International Nuclear Information System (INIS)

    Ando, Yasumasa.

    1992-01-01

    Since highly reliable operation is required in a nuclear power plant, monitoring during operation and periodical inspection are conducted carefully. The present invention provides maintenance and management systems for providing an aid so that these systems are combined effectively and operated rationally based on unified information management. That is, the system contains data bases comprising information for the design of the equipments and pipelines of a plant, information for the exchange of equipment parts, information for the history of plant operation, information for the monitoring and inspection, and information for the management of repair operation. In addition, it has an equipment part history management sub-system for managing equipment part exchange information, an operation history management sub-system for managing the operation state of the plant, an operation history management sub-system for managing equipment monitoring inspection data and operation management sub-system for managing periodical inspection/ repairing operation. These sub-systems are collectively combined to manage the maintenance and management jobs of the plant unitarily. (I.S.)

  8. Operation and maintenance results from ISFOC CPV plants

    Science.gov (United States)

    Gil, Eduardo; Martinez, María; de la Rubia, Oscar

    2017-09-01

    The analysis of field operation and maintenance data collected during a period of over eight years, from CPV installations consisting of three different CPV technologies (including second generation of one of these technologies), has allowed us to get valuable information about the long-term degradation of the CPV systems. Through the study of the maintenance control ratio previously defined and by applying the root cause analysis methodology, the components responsible for the most unplanned interventions for each technology were identified. Focusing maintenance efforts on these components, a reduction of the unplanned interventions and the total cost of maintenance has been achieved over the years. Therefore, the deployment of an effective maintenance plan, identifying critical components, is essential to minimize the risk for investors and maximize the CPV power plants lifetime and energy output, increasing the availability of CPV installations, boosting market confidence in CPV systems.

  9. The Regularity and Irregularity of Travel: an Analysis of the Consistency of Travel Times Associated with Subsistence, Maintenance and Discretionary Activities

    OpenAIRE

    Longden, Thomas

    2016-01-01

    Regular and irregular travel patterns coincide with different underlying purposes of travel and days of the week. Within this paper, it is shown that the balance between subsistence (i.e. work) and discretionary (i.e. leisure) activities is related to differences in travel patterns and explains consistency across years. Using eight years of time use diary entries this paper finds that travel time related to subsistence activities tends to be regular and stable. In contrast, travel time associ...

  10. CANDU plant maintenance: Recent developments

    International Nuclear Information System (INIS)

    Charlebois, P.

    2000-01-01

    CANDU units have long been recognized for their exceptional safety and reliability. Continuing development in the maintenance area has played a key role in achieving this performance level. For over two decades, safety system availability has been monitored closely and system maintenance programs adjusted accordingly to maintain high levels of performance. But as the plants approach mid life in a more competitive environment and component aging becomes a concern, new methods and techniques are necessary. As a result, recent developments are moving the maintenance program largely from a corrective and preventive approach to predictive and condition based maintenance. The application of these techniques is also being extended to safety related systems. These recent developments include use of reliability centred methods to define system maintenance requirements and strategies. This approach has been implemented on a number of systems at Canadian CANDU plants with positive results. The pilot projects demonstrated that the overall maintenance effort remained relatively constant while the system performance improved. It was also possible to schedule some of the redundant component maintenance during plant operation without adverse impact on system availability. The probabilistic safety assessment was found to be useful in determining the safety implications of component outages. These new maintenance strategies are now making use of predictive and condition based maintenance techniques to anticipate equipment breakdown and schedule preventive maintenance as the need arises rather than time based. Some of these techniques include valve diagnostics, vibration monitoring, oil analysis, thermography. Of course, these tools and techniques must form part of an overall maintenance management system to ensure that maintenance becomes a living program. To facilitate this process and contain costs, new information technology tools are being introduced to provide system engineers

  11. The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+Entry.

    Science.gov (United States)

    Malli, Roland; Graier, Wolfgang F

    2017-01-01

    In most cell types, the depletion of internal Ca 2+ stores triggers the activation of Ca 2+ entry. This crucial phenomenon is known since the 1980s and referred to as store-operated Ca 2+ entry (SOCE). With the discoveries of the stromal-interacting molecules (STIMs) and the Ca 2+ -permeable Orai channels as the long-awaited molecular constituents of SOCE, the role of mitochondria in controlling the activity of this particular Ca 2+ entry pathway is kind of buried in oblivion. However, the capability of mitochondria to locally sequester Ca 2+ at sites of Ca 2+ release and entry was initially supposed to rule SOCE by facilitating the Ca 2+ depletion of the endoplasmic reticulum and removing entering Ca 2+ from the Ca 2+ -inhibitable channels, respectively. Moreover, the central role of these organelles in controlling the cellular energy metabolism has been linked to the activity of SOCE. Nevertheless, the exact molecular mechanisms by which mitochondria actually determine SOCE are still pretty obscure. In this essay we describe the complexity of the mitochondrial Ca 2+ uptake machinery and its regulation, molecular components, and properties, which open new ways for scrutinizing the contribution of mitochondria to SOCE. Moreover, data concerning the variability of the morphology and cellular distribution of mitochondria as putative determinants of SOCE activation, maintenance, and termination are summarized.

  12. Decreasing inventory of a cement factory roller mill parts using reliability centered maintenance method

    Science.gov (United States)

    Witantyo; Rindiyah, Anita

    2018-03-01

    According to data from maintenance planning and control, it was obtained that highest inventory value is non-routine components. Maintenance components are components which procured based on maintenance activities. The problem happens because there is no synchronization between maintenance activities and the components required. Reliability Centered Maintenance method is used to overcome the problem by reevaluating maintenance activities required components. The case chosen is roller mill system because it has the highest unscheduled downtime record. Components required for each maintenance activities will be determined by its failure distribution, so the number of components needed could be predicted. Moreover, those components will be reclassified from routine component to be non-routine component, so the procurement could be carried out regularly. Based on the conducted analysis, failure happens in almost every maintenance task are classified to become scheduled on condition task, scheduled discard task, schedule restoration task and no schedule maintenance. From 87 used components for maintenance activities are evaluated and there 19 components that experience reclassification from non-routine components to routine components. Then the reliability and need of those components were calculated for one-year operation period. Based on this invention, it is suggested to change all of the components in overhaul activity to increase the reliability of roller mill system. Besides, the inventory system should follow maintenance schedule and the number of required components in maintenance activity so the value of procurement will be decreased and the reliability system will increase.

  13. Department of the Navy Justification of Estimates for Fiscal Year 1985 Submitted to Congress February 1984. Operation & Maintenance, Navy. Book 3. Budget Activity 3. Intelligence & Communications. Budget Activity 8. Training, Medical & OGPA. Budget Activity 9. Administration & Assoc Acts. Budget Activity 10. Support to Other Nations

    Science.gov (United States)

    1984-02-01

    el ectricity generating plants, purchased steam and hot water, heat plants, utility distribucion systems, waste systems, air conditioning and...training courese; software support services for normal life cycle maintenance of flight simulators and simulated maintenance trainers for both in-productijon...plants and supersonic capability in support of fleet requirements. This training is apart from the normal Chief of Naval Education Training sponsored

  14. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  15. Data quality maintenance of the Patient Master Index (PMI): a "snap-shot" of public healthcare facility PMI data quality and linkage activities.

    Science.gov (United States)

    Williams, Kelly; Robinson, Kerin; Toth, Alexandra

    Patient (or person) master index (PMI) data quality activities in public, acute healthcare facilities in the state of Victoria, Australia were evaluated in terms of health information management-information technology best practice including data standards and practice guidelines. The findings indicate that, whilst data quality and linkage activities are undertaken, many are limited in scope or effectiveness. In view of published evidence that: (i) duplicate patient files pose significant risks by reducing information available for clinical decision-making; and (ii) quality and clinical risk management require, as a measurable outcome, continuous monitoring of duplicate files, improvements to PMI data quality practices are recommended.

  16. Fuzzy Logic Reliability Centered Maintenance

    Directory of Open Access Journals (Sweden)

    Felecia .

    2014-01-01

    Full Text Available Reliability Centered Maintenence (RCM is a systematic maintenence strategy based on system reliability. Application of RCM process will not always come out with a binary output of “yes” and “no”. Most of the time they are not supported with available detail information to calculate system reliability. The fuzzy logic method attempts to eliminate the uncertainty by providing “truth” in different degrees.Data and responses from maintenance department will be processed using the two methods (reliability centered maintenance and fuzzy logic to design maintenance strategy for the company. The results of the fuzzy logic RCM application are maintenance strategy which fit with current and future condition.

  17. Functional co-activation within the prefrontal cortex supports the maintenance of behavioural performance in fear-relevant situations before an iTBS modulated virtual reality challenge in participants with spider phobia.

    Science.gov (United States)

    Deppermann, S; Notzon, S; Kroczek, A; Rosenbaum, D; Haeussinger, F B; Diemer, J; Domschke, K; Fallgatter, A J; Ehlis, A-C; Zwanzger, P

    2016-07-01

    A number of studies/meta-analyses reported moderate antidepressant effects of activating repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC). Regarding the treatment of anxiety, study outcomes are inconsistent, probably because of the heterogenity of anxiety disorders/study designs. To specifically evaluate the impact of rTMS on emotion regulation in fear-relevant situations we applied a sham-controlled activating protocol (intermittent Theta Burst Stimulation/iTBS) over the left PFC (F3) succeeded by a virtual reality (VR) challenge in n=41 participants with spider phobia and n=42 controls. Prior to/after iTBS and following VR prefrontal activation was assessed by functional near-infrared spectroscopy during an emotional Stroop paradigm. Performance (reaction times/error rates) was evaluated. Stimuli were rated regarding valence/arousal at both measurements. We found diminished activation in the left inferior frontal gyrus (IFG) of participants with spider phobia compared to controls, particularly elicited by emotionally-irrelevant words. Simultaneously, a functional connectivity analysis showed increased co-activation between the left IFG and the contra-lateral hemisphere. Behavioural performance was unimpaired. After iTBS/VR no significant differences in cortical activation between the phobic and control group remained. However, verum-iTBS did not cause an additional augmentation. We interpreted our results in terms of a prefrontal network which gets activated by emotionally-relevant stimuli and supports the maintenance of adequate behavioural reactions. The missing add-on effects of iTBS might be due to a ceiling effect of VR, thereby supporting its potential during exposure therapy. Concurrently, it implies that the efficient application of iTBS in the context of emotion regulation still needs to be studied further. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. An Internet- and mobile-based tailored intervention to enhance maintenance of physical activity after cardiac rehabilitation: short-term results of a randomized controlled trial.

    Science.gov (United States)

    Antypas, Konstantinos; Wangberg, Silje C

    2014-03-11

    An increase in physical activity for secondary prevention of cardiovascular disease and cardiac rehabilitation has multiple therapeutic benefits, including decreased mortality. Internet- and mobile-based interventions for physical activity have shown promising results in helping users increase or maintain their level of physical activity in general and specifically in secondary prevention of cardiovascular diseases and cardiac rehabilitation. One component related to the efficacy of these interventions is tailoring of the content to the individual. Our trial assessed the effect of a longitudinally tailored Internet- and mobile-based intervention for physical activity as an extension of a face-to-face cardiac rehabilitation stay. We hypothesized that users of the tailored intervention would maintain their physical activity level better than users of the nontailored version. The study population included adult participants of a cardiac rehabilitation program in Norway with home Internet access and a mobile phone. The participants were randomized in monthly clusters to a tailored or nontailored (control) intervention group. All participants had access to a website with information regarding cardiac rehabilitation, an online discussion forum, and an online activity calendar. Those using the tailored intervention received tailored content based on models of health behavior via the website and mobile fully automated text messages. The main outcome was self-reported level of physical activity, which was obtained using an online international physical activity questionnaire at baseline, at discharge, and at 1 month and 3 months after discharge from the cardiac rehabilitation program. Included in the study were 69 participants. One month after discharge, the tailored intervention group (n=10) had a higher median level of overall physical activity (median 2737.5, IQR 4200.2) than the control group (n=14, median 1650.0, IQR 2443.5), but the difference was not significant

  19. Experience in scheduled maintenance

    International Nuclear Information System (INIS)

    Tsai, M.T.

    1985-01-01

    As outage management affects both the cost and reliability of a nuclear power plant, performance of a scheduled maintenance outage in an efficient and effective manner is an important task in the operation of nuclear power plant. This paper covers the experience gained in the past ten refueling outages for the two BWR units at the First Nuclear Power Station of Taipower. The key to optimizing both the cost and schedule of a refueling outage is to maintain a high level of quality workmanship. The outage management in planning, scheduling, preparation, coordination, and cooperation, accompanied by the qualified in-house capability and sufficient outside support, have placed the refueling outages at the FNPS in a well controlled situation and have established the capacity factors of these two BWR units at a level which is 20% higher than the world average in the past years

  20. Subcontracting Railway Maintenance

    DEFF Research Database (Denmark)

    Thommesen, Jacob

    2010-01-01

    railway infrastructure manager (InfraMan), whichis subcontracting maintenance tasks to other companies. InfraMan has implemented various central elements in managing their subcontractors. The latter are required to present a safety plan as part of their bid, they must be approved if they are to be awarded...... the informal competencies, and a dilemma in options for sanctioning unsafe behavior. These and other dilemmas faced by the Danish railway company are analyzed as general challenges related to subcontracting and compared to similar experiences in other industries. Note: the study reported here, while partly......In several European countries, national railway operators have been dismantled and partly privatized to create new contractual relations where operations originally performed internally are now outsourced to several companies. Breaking up work across several independent organizational...

  1. Cofrentes maintenance. Life essence

    International Nuclear Information System (INIS)

    Sala, J.

    2009-01-01

    Even though it may seem like something much more complex, maintenance is not more than the seed of continuity, the alchemy of eternal youth or the key to combating the cruel passage of time that haunts us all. Little does it matter where you are from or where you are going; it is irrelevant whether you are man, woman or machine. If you do not have a more or less sensible strategy of survival, reality can take you by surprise, without prior warning, at the wrong place and the wrong time. It is sad to see how what we thought was eternal, and thus do not care for and pamper as we should, eventually loses its qualities and functions over the years and fades away like a vague memory. (Author)

  2. PSO Based Optimization of Testing and Maintenance Cost in NPPs

    Directory of Open Access Journals (Sweden)

    Qiang Chou

    2014-01-01

    Full Text Available Testing and maintenance activities of safety equipment have drawn much attention in Nuclear Power Plant (NPP to risk and cost control. The testing and maintenance activities are often implemented in compliance with the technical specification and maintenance requirements. Technical specification and maintenance-related parameters, that is, allowed outage time (AOT, maintenance period and duration, and so forth, in NPP are associated with controlling risk level and operating cost which need to be minimized. The above problems can be formulated by a constrained multiobjective optimization model, which is widely used in many other engineering problems. Particle swarm optimizations (PSOs have proved their capability to solve these kinds of problems. In this paper, we adopt PSO as an optimizer to optimize the multiobjective optimization problem by iteratively trying to improve a candidate solution with regard to a given measure of quality. Numerical results have demonstrated the efficiency of our proposed algorithm.

  3. Improving human performance in maintenance personnel

    International Nuclear Information System (INIS)

    Gonzalez Anez, Francisco; Agueero Agueero, Jorge

    2010-01-01

    The continuous evolution and improvement of safety-related processes has included the analysis, design and development of training plans for the qualification of maintenance nuclear power plant personnel. In this respect, the international references in this area recommend the establishment of systematic qualification programmes for personnel performing functions or carrying out safety related tasks. Maintenance personnel qualification processes have improved significantly, and training plans have been designed and developed based on Systematic Approach to Training methodology to each job position. These improvements have been clearly reflected in recent training programmes with new training material and training facilities focused not only on developing technical knowledge and skills but also on improving attitudes and safety culture. The objectives of maintenance training facilities such as laboratories, mock-ups real an virtual, hydraulic loops, field simulators and other training material to be used in the maintenance training centre are to cover training necessities for initial and continuous qualification. Evidently, all these improvements made in the qualification of plant personnel should be extended to include supplemental personnel (external or contracted) performing safety-related tasks. The supplemental personnel constitute a very spread group, covering the performance of multiple activities entailing different levels of responsibility. Some of these activities are performed permanently at the plant, while others are occasional or sporadic. In order to establish qualification requirements for these supplemental workers, it is recommended to establish a rigorous analysis of job positions and tasks. The objective will be to identify the qualification requirements to assure competence and safety. (authors)

  4. Risk-based maintenance modeling. Prioritization of maintenance importances and quantification of maintenance effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Vesely, W.E.; Rezos, J.T. [Science Applications International Corp., Dublin, OH (United States)

    1995-09-01

    This report describes methods for prioritizing the risk importances of maintenances using a Probabilistic Risk Assessment (PRA). Approaches then are described for quantifying their reliability and risk effects. Two different PRA importance measures, minimal cutset importances and risk reduction importances, were used to prioritize maintenances; the findings show that both give similar results if appropriate criteria are used. The justifications for the particular importance measures also are developed. The methods developed to quantify the reliability and risk effects of maintenance actions are extensions of the usual reliability models now used in PRAs. These extended models consider degraded states of the component, and quantify the benefits of maintenance in correcting degradations and preventing failures. The negative effects of maintenance, including downtimes, also are included. These models are specific types of Markov models. The data for these models can be obtained from plant maintenance logs and from the Nuclear Plant Reliability Data System (NPRDS). To explore the potential usefulness of these models, the authors analyzed a range of postulated values of input data. These models were used to examine maintenance effects on a components reliability and performance for various maintenance programs and component data. Maintenance schedules were analyzed to optimize the component`s availability. In specific cases, the effects of maintenance were found to be large.

  5. Buildings Lean Maintenance Implementation Model

    Science.gov (United States)

    Abreu, Antonio; Calado, João; Requeijo, José

    2016-11-01

    Nowadays, companies in global markets have to achieve high levels of performance and competitiveness to stay "alive".Within this assumption, the building maintenance cannot be done in a casual and improvised way due to the costs related. Starting with some discussion about lean management and building maintenance, this paper introduces a model to support the Lean Building Maintenance (LBM) approach. Finally based on a real case study from a Portuguese company, the benefits, challenges and difficulties are presented and discussed.

  6. New remote maintenance approach for TPX

    International Nuclear Information System (INIS)

    Davis, F.C.; Walker, M.S.; Brown, T.G.

    1993-01-01

    The Tokamak Physics Experiment (TPX), to be located at Princeton Plasma Physics Laboratory, will be a steady-state, high-performance fusion machine. It will use hydrogen fuel during its original operation, deuterium-deuterium (D-D) fuel for an extended intermediate period of time and then a limited number of runs using deuterium-tritium (D-T) fuel. The D-D operations wig generate neutron fluxes that will activate materials of the vacuum vessel. From that point on, the resulting ionizing radiation, which will continue to increase, particularly during D-T operation, will prevent personnel access into the vessel to perform either scheduled or unscheduled maintenance activities. All activities performed within the vacuum vessel must be accomplished using remote means. TPX has taken a new approach for remote maintenance of the components within the vacuum vessel. This document describes the system that is being developed

  7. Determination of Pareto frontier in multi-objective maintenance optimization

    International Nuclear Information System (INIS)

    Certa, Antonella; Galante, Giacomo; Lupo, Toni; Passannanti, Gianfranco

    2011-01-01

    The objective of a maintenance policy generally is the global maintenance cost minimization that involves not only the direct costs for both the maintenance actions and the spare parts, but also those ones due to the system stop for preventive maintenance and the downtime for failure. For some operating systems, the failure event can be dangerous so that they are asked to operate assuring a very high reliability level between two consecutive fixed stops. The present paper attempts to individuate the set of elements on which performing maintenance actions so that the system can assure the required reliability level until the next fixed stop for maintenance, minimizing both the global maintenance cost and the total maintenance time. In order to solve the previous constrained multi-objective optimization problem, an effective approach is proposed to obtain the best solutions (that is the Pareto optimal frontier) among which the decision maker will choose the more suitable one. As well known, describing the whole Pareto optimal frontier generally is a troublesome task. The paper proposes an algorithm able to rapidly overcome this problem and its effectiveness is shown by an application to a case study regarding a complex series-parallel system.

  8. Darlington Station outage - a maintenance perspective

    Energy Technology Data Exchange (ETDEWEB)

    Plourde, J.; Marczak, J.; Stone, M.; Myers, R.; Sutton, K. [Ontario Hydro, Darlington Nuclear Generating Station, Bowmanville, ON (Canada)

    1997-07-01

    Ontario Hydro's Darlington Nuclear Generating Station (4x881MW(e)net) has carried out its first station outage since full commercial operation. The outage presented challenges to the organization in terms of outage planning, support, management, and safe execution within the constraints of schedule, budget and resources. This paper will focus on the success of the outage maintenance program, identifying the major work programs - a vacuum structure and containment outage, an emergency service water system outage, an emergency coolant injection system outage, intake channel inspections, low pressure service water inspections, and significant outage maintenance work on each of the four reactor units. Planning for the outage was initiated early in anticipation of this important milestone in the station's life. Detailed safety reviews - nuclear, radiation, and conventional - were conducted in support of the planned maintenance program. System lineup and work protection were provided by the Station Operator work group. Work protection permitry was initiated well in advance of the outage. Station maintenance staff resources were bolstered in support of the outage to ensure program execution could be maintained within the schedule. Training programs were in place to ensure that expectations were clear and that high standards would be maintained. Materials management issues in support of maintenance activities were given high priority to ensure no delays to the planned work. Station management review and monitoring in preparation for and during the outage ensured that staff priorities remained focused. Lessons learned from the outage execution are being formalized in maintenance procedures and outage management procedures, and shared with the nuclear community. (author)

  9. Darlington Station outage - a maintenance perspective

    International Nuclear Information System (INIS)

    Plourde, J.; Marczak, J.; Stone, M.; Myers, R.; Sutton, K.

    1997-01-01

    Ontario Hydro's Darlington Nuclear Generating Station (4x881MW(e)net) has carried out its first station outage since full commercial operation. The outage presented challenges to the organization in terms of outage planning, support, management, and safe execution within the constraints of schedule, budget and resources. This paper will focus on the success of the outage maintenance program, identifying the major work programs - a vacuum structure and containment outage, an emergency service water system outage, an emergency coolant injection system outage, intake channel inspections, low pressure service water inspections, and significant outage maintenance work on each of the four reactor units. Planning for the outage was initiated early in anticipation of this important milestone in the station's life. Detailed safety reviews - nuclear, radiation, and conventional - were conducted in support of the planned maintenance program. System lineup and work protection were provided by the Station Operator work group. Work protection permitry was initiated well in advance of the outage. Station maintenance staff resources were bolstered in support of the outage to ensure program execution could be maintained within the schedule. Training programs were in place to ensure that expectations were clear and that high standards would be maintained. Materials management issues in support of maintenance activities were given high priority to ensure no delays to the planned work. Station management review and monitoring in preparation for and during the outage ensured that staff priorities remained focused. Lessons learned from the outage execution are being formalized in maintenance procedures and outage management procedures, and shared with the nuclear community. (author)

  10. On-line maintenance PSA support at NPP Krsko

    International Nuclear Information System (INIS)

    Prosen, R.; Vrbanic, I.; Kastelan, M.

    2000-01-01

    In 1997 Krsko NPP initiated the on-line maintenance (OLM) practice. On-line maintenance constitutes of corrective activities, preventive activities, surveillance activities, tests and inspections, as well as calibrations and modifications, taking place during the normal power operations. The on-line maintenance is a multidisciplinary process consisting of activity specification, planning, and preparation and performing of the OLM activity of interest. The primary role of the PSA group is to assess from the r isk perspective , using the plant-specific NEK PSA model, system unavailability and the impact to the plant operational risk. The intent is to support planning of the on-line maintenance activities from the risk perspective. The risk evaluation of the OLM activities is based on the probability of core damage evaluation for the defined discrete plant configuration states, determined by the OLM activities. Within this application, the optimized, plant-specific PSA model is used on Risk Spectrum platform. To perform the risk assessment of the on-line maintenance activities, first the systems to be affected are defined based on the planned OLM activities. The next important step is the assessment of the planned work schedule. To define the final schedule, the co-ordination and optimizing the planned OLM activities needs activation of all participating departments, supported also from PSA group. The P3 (i.e. Primavera) planning tool system windows are defined for different systems and groups of systems, and the activities are sorted in particular weeks according to these windows. (author)

  11. Remote maintenance development for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Tada, Eisuke [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Shibanuma, Kiyoshi

    1998-04-01

    This paper describes the overall ITER remote maintenance design concept developed mainly for in-vessel components such as diverters and blankets, and outlines the ITER R and D program to develop remote handling equipment and radiation hard components. Reactor structures inside the ITER cryostat must be maintained remotely due to DT operation, making remote handling technology basic to reactor design. The overall maintenance scenario and design concepts have been developed, and maintenance design feasibility, including fabrication and testing of full-scale in-vessel remote maintenance handling equipment and tool, is being verified. (author)

  12. Maintenance risk management in Dayabay nuclear power plant

    International Nuclear Information System (INIS)

    He Xuhong; Tong Jiejuan

    2005-01-01

    The importance of proper maintenance to safe and reliable nuclear plant operation has long been recognized by the nuclear utility and regulatory body. This paper presents a process of maintenance risk management developed for a Chinese Nuclear Power Plant (NPP). The process includes three phases: (I) long term maintenance plan risk management, (II) monthly maintenance plan risk management, and (III) detailed risk management for high risk configuration. A risk matrix is developed for phase I whose purpose is to provide a rough guide for risk management in the making of the annual maintenance plan. For Phase II and Phase III, a software tool named Maintenance- Risk-Monitor is developed based on the internal initiating event, level 1 PSA model. The results of Phase II are the risk information of the all plant configurations caused by the unavailability of the components included the monthly maintenance plan. When the increase of core damage frequency (CDF) or the incremental core damage probability (ICDP) of a configuration is higher than the corresponding thresholds, Phase III is needed for this high risk configuration to get the useful information such as risk-importance components, human actions and initial events, from which appropriate preventive measurements could be derived. It is hoped that the provided process of maintenance risk management, together with the developed software tool, could facilitate the maintenance activities in the NPPs of China. (authors)

  13. Joint optimization of production scheduling and machine group preventive maintenance

    International Nuclear Information System (INIS)

    Xiao, Lei; Song, Sanling; Chen, Xiaohui; Coit, David W.

    2016-01-01

    Joint optimization models were developed combining group preventive maintenance of a series system and production scheduling. In this paper, we propose a joint optimization model to minimize the total cost including production cost, preventive maintenance cost, minimal repair cost for unexpected failures and tardiness cost. The total cost depends on both the production process and the machine maintenance plan associated with reliability. For the problems addressed in this research, any machine unavailability leads to system downtime. Therefore, it is important to optimize the preventive maintenance of machines because their performance impacts the collective production processing associated with all machines. Too lengthy preventive maintenance intervals may be associated with low scheduled machine maintenance cost, but may incur expensive costs for unplanned failure due to low machine reliability. Alternatively, too frequent preventive maintenance activities may achieve the desired high reliability machines, but unacceptably high scheduled maintenance cost. Additionally, product scheduling plans affect tardiness and maintenance cost. Two results are obtained when solving the problem; the optimal group preventive maintenance interval for machines, and the assignment of each job, including the corresponding start time and completion time. To solve this non-deterministic polynomial-time problem, random keys genetic algorithms are used, and a numerical example is solved to illustrate the proposed model. - Highlights: • Group preventive maintenance (PM) planning and production scheduling are jointed. • Maintenance interval and assignment of jobs are decided by minimizing total cost. • Relationships among system age, PM, job processing time are quantified. • Random keys genetic algorithms (GA) are used to solve the NP-hard problem. • Random keys GA and Particle Swarm Optimization (PSO) are compared.

  14. Department of the Navy Justification of Estimates for Fiscal Year 1985 Submitted to Congress February 1984. Operation & Maintenance, Navy. Book 1. Budget Activity 1. Strategic Forces Budget. Activity 2. General Purpose Forces. Budget Activity 4. Airlift and Sealift.

    Science.gov (United States)

    1984-02-01

    146,459 Sealift Prepositioning 230,752 Fleet Support 234,181 Base Support 1,433,505 NIF & NSF Support -16,083 AVDLR Credits TOTAL, General...Activities Training Medical Support Personnel Support Base Operations NIF /Stockfund Support AVDLR Credi ts TOTAL, Training, Medical, and...8217 .-* v> •;. • •; < t *#» V "„**"•’ V V ’-• ’•; • -, ^w **u *"» * • *> ".* ’ •T^r^r; • *’ ."" V\\ *•. IT", ^". -\\ - • . - • CO <o ^Q UO •— c6

  15. IMIS: Integrated Maintenance Information System. A maintenance information delivery concept

    Science.gov (United States)

    Vonholle, Joseph C.

    1987-01-01

    The Integrated Maintenance Information System (IMIS) will optimize the use of available manpower, enhance technical performance, improve training, and reduce the support equipment and documentation needed for deployment. It will serve as the technician's single, integrated source of all the technical information required to perform modern aircraft maintenance.

  16. Condition based maintenance in the context of opportunistic maintenance

    NARCIS (Netherlands)

    Koochaki, Javid; Bokhorst, Jos A. C.; Wortmann, Hans; Klingenberg, Warse

    2012-01-01

    Condition based maintenance (CBM) uses the operating condition of a component to predict a failure event. Compared to age based replacement (ABR), CBM usually results in higher availability and lower maintenance costs, since it tries to prevent unplanned downtime and avoid unnecessary preventive

  17. Effect of chitosan coating on maintenance of aril quality, microbial population and PPO activity of pomegranate (Punica granatum L. cv. Tarom) at cold storage temperature.

    Science.gov (United States)

    Ghasemnezhad, Mahmood; Zareh, Somayeh; Rassa, Mehdi; Sajedi, Reza H

    2013-01-01

    Chitosan edible coating was used in an attempt to extend the storage life of pomegranate arils during 12 days at 4 °C. Prior to storage, treated arils were dipped in 0.25, 0.5 and 1% (w/v) chitosan aqueous solutions and 1% (v/v) acetic acid for 1 min, while control arils were dipped in distilled water with 1% (v/v) acetic acid. Chitosan coating inhibited bacterial and fungal growth on the surface of arils. The water content of arils coated with 0.5 and 1% chitosan was maintained during 12 days of storage. Chitosan reduced the increase in total soluble solids (TSS) and titratable acidity (TA) of arils during storage. The lowest TSS and TA were detected in arils coated with 0.5 and 1% chitosan, which maintained the highest TSS/TA ratio after 12 days of storage. In contrast, application of chitosan delayed the decrease in total phenolics, total anthocyanins and antioxidant capacity during storage. The results also showed that chitosan coating suppressed the monophenolase activity of polyphenol oxidase (PPO) with pyrogallol substrate and the diphenolase activity of PPO with dopamine hydrochloride substrate, but the diphenolase activity of PPO with pyrocatechol substrate increased during storage. The results suggest that chitosan coating has the potential to extend the storage life of pomegranate arils by reducing the microbial population on their surface. Copyright © 2012 Society of Chemical Industry.

  18. Maintenance implementation plan for the B Plant/WESF. Revision 4

    International Nuclear Information System (INIS)

    Tritt, S.E.; Lueck, B.H.

    1996-01-01

    This Maintenance Implementation Plan (MIP) has been developed for maintenance functions associated with the B Plant/WESF (Waste Encapsulation Storage Facility) complex. The objective of this plan is to provide baseline information for establishing and identifying WHC conformance programs and policies applicable to implementation of DOE order 4330.4B guidelines. In addition, this maintenance plan identifies the actions necessary to develop a cost-effective and efficient maintenance program at B Plant/WESF. The B Plant WESF facility complex consists of three main facilities and several support structures located in the 200 East Area of the Hanford site. B Plant is a transition facility that is required to ensure safe storage and management of WESF (operating facility) cesium and strontium capsules. B Plant/WESF also contains substantial radiological inventory from previous campaigns. There are no production activities at B Plant, but several of its operating systems are required to accomplish the current B Plant/WESF mission. B Plant/WESF are each considered a nuclear facility due to the storage of cesium and strontium capsules at WESF and the large radiological inventory from past processing

  19. Criteria and model for assessing and improving information technology maturity within maintenance

    International Nuclear Information System (INIS)

    Kans, M; Ehsanifard, K; Moniri, A

    2012-01-01

    Maintenance optimization and decision-making processes have been both influenced considerably by Information Technology (IT) developments mainly by increasing data availability. The decision-making process in its turn has affected systems trustworthiness positively. Therefore, theoretically speaking it could be said that Maintenance Management Information technology (MMIT) has the potential to provide applicable solutions for many of the maintenance management problems. Nevertheless, this potential has been hardly experienced in practice because of the mismatch between the level of IT maturity in the organizations and their selected MMIT solutions. To fill this gap this paper suggests a number of criteria which are crucial in decision making for selecting a MMIT application. The criteria are formed based on previous findings utilising an extensive literature review. A model is further developed for this purpose which is also tested on a case company active in power generation in Sweden. The model proved to be helpful when taking further improvement steps for reaching high utilization of IT in maintenance.

  20. Conversion of a mainframe simulation for maintenance performance to a PC environment

    International Nuclear Information System (INIS)

    Gertman, D.I.

    1991-01-01

    A computer-based simulation capable of generating human error probabilities (HEPs) for maintenance activities is presented. The HEPs are suitable for use in probabilistic risk assessments (PRAs) and are an important source of information for data management systems such as NUCLARR- the Nuclear Computerized Library for Assessing Reactor Reliability. (1) The basic computer model MAPPS--the maintenance personnel performance simulation has been developed and validated by the US NRC in order to improve maintenance practices and procedures at nuclear power plants. This model validated previously, has now been implemented and improved, in a PC environment, and renamed MicroMAPPS. The model is stochastically based, able to simulate the performance of 2 to 15 person crews for a variety of maintenance conditions. These conditions include aspects of crew actions as potentially influenced by the task, the environment, or characteristics of the personnel involved. The nature of the software code makes it particularly appropriate for determining changes in HEP rates due to fluctuations in important task, environment,. or personnel parameters. The presentation presents a brief review of the mainframe version of the code and presents a summarization of the enhancements which dramatically change the nature of the human computer interaction

  1. Concomitant and previous osteoporotic vertebral fractures.

    Science.gov (United States)

    Lenski, Markus; Büser, Natalie; Scherer, Michael

    2017-04-01

    Background and purpose - Patients with osteoporosis who present with an acute onset of back pain often have multiple fractures on plain radiographs. Differentiation of an acute osteoporotic vertebral fracture (AOVF) from previous fractures is difficult. The aim of this study was to investigate the incidence of concomitant AOVFs and previous OVFs in patients with symptomatic AOVFs, and to identify risk factors for concomitant AOVFs. Patients and methods - This was a prospective epidemiological study based on the Registry of Pathological Osteoporotic Vertebral Fractures (REPAPORA) with 1,005 patients and 2,874 osteoporotic vertebral fractures, which has been running since February 1, 2006. Concomitant fractures are defined as at least 2 acute short-tau inversion recovery (STIR-) positive vertebral fractures that happen concomitantly. A previous fracture is a STIR-negative fracture at the time of initial diagnostics. Logistic regression was used to examine the influence of various variables on the incidence of concomitant fractures. Results - More than 99% of osteoporotic vertebral fractures occurred in the thoracic and lumbar spine. The incidence of concomitant fractures at the time of first patient contact was 26% and that of previous fractures was 60%. The odds ratio (OR) for concomitant fractures decreased with a higher number of previous fractures (OR =0.86; p = 0.03) and higher dual-energy X-ray absorptiometry T-score (OR =0.72; p = 0.003). Interpretation - Concomitant and previous osteoporotic vertebral fractures are common. Risk factors for concomitant fractures are a low T-score and a low number of previous vertebral fractures in cases of osteoporotic vertebral fracture. An MRI scan of the the complete thoracic and lumbar spine with STIR sequence reduces the risk of under-diagnosis and under-treatment.

  2. Air Force Depot Maintenance: Analysis of Its Financial Operations

    National Research Council Canada - National Science Library

    1999-01-01

    The Air Force depot maintenance activity group is part of the Air Force Working Capital Fund, a revolving fund that relies on sales revenue rather than direct congressional appropriations to finance its operations...

  3. The economy of preventive maintenance of concrete bridges : final report.

    Science.gov (United States)

    2016-03-01

    The most economical approach to maintain existing concrete bridges is by adopting an active preventive maintenance : approach. An in-depth investigation of the combined deterioration effects of various deterioration mechanisms is needed : to establis...

  4. Uterine rupture without previous caesarean delivery

    DEFF Research Database (Denmark)

    Thisted, Dorthe L. A.; H. Mortensen, Laust; Krebs, Lone

    2015-01-01

    OBJECTIVE: To determine incidence and patient characteristics of women with uterine rupture during singleton births at term without a previous caesarean delivery. STUDY DESIGN: Population based cohort study. Women with term singleton birth, no record of previous caesarean delivery and planned...... vaginal delivery (n=611,803) were identified in the Danish Medical Birth Registry (1997-2008). Medical records from women recorded with uterine rupture during labour were reviewed to ascertain events of complete uterine rupture. Relative Risk (RR) and adjusted Relative Risk Ratio (aRR) of complete uterine...... rupture with 95% confidence intervals (95% CI) were ascertained according to characteristics of the women and of the delivery. RESULTS: We identified 20 cases with complete uterine rupture. The incidence of complete uterine rupture among women without previous caesarean delivery was about 3...

  5. Landscaping With Maintenance in Mind.

    Science.gov (United States)

    Sorensen, Randy

    2000-01-01

    Examines school ground landscape design that enhances attractive of the school and provides for easier maintenance. Landscape design issues discussed include choice of grass, trees, and shrubs; irrigation; and safety and access. Other considerations for lessening maintenance problems for facility managers are also highlighted. (GR)

  6. The Nordic maintenance care program

    DEFF Research Database (Denmark)

    Myburgh, Corrie; Brandborg-Olsen, Dorthe; Albert, Hanne

    2013-01-01

    To describe and interpret Danish Chiropractors' perspectives regarding the purpose and rationale for using MC (maintenance care), its content, course and patient characteristics.......To describe and interpret Danish Chiropractors' perspectives regarding the purpose and rationale for using MC (maintenance care), its content, course and patient characteristics....

  7. Maintenance Planning for Historic Buildings

    Directory of Open Access Journals (Sweden)

    Diana Plian

    2008-01-01

    Full Text Available The key to good maintenance of historic buildings is a long-range maintenance plan. Long-range planning recognizes a responsibility to the future to prolong the useful life of a building by preserving it in its present condition and preventing or slowing deterioration and damage from natural or other causes.

  8. The Diabetes Intention, Attitude, and Behavior Questionnaire: evaluation of a brief questionnaire to measure physical activity, dietary control, maintenance of a healthy weight, and psychological antecedents.

    Science.gov (United States)

    Traina, Shana B; Mathias, Susan D; Colwell, Hilary H; Crosby, Ross D; Abraham, Charles

    2016-01-01

    This study assessed measurement properties of the 17-item Diabetes Intention, Attitude, and Behavior Questionnaire (DIAB-Q), which measures intention to engage in self-care behaviors, including following a diabetes diet and engaging in appropriate physical activity. The DIAB-Q includes questions based on the Theory of Planned Behavior. Items were developed using published literature, input from health care professionals, and qualitative research findings in patients with and without type 2 diabetes mellitus (T2DM). In Stage I of the study, 23 adults with T2DM were interviewed to evaluate the content and clarity of the DIAB-Q. In Stage II 1,015 individuals with T2DM completed the DIAB-Q and supplemental questionnaires, including the Short Form-36 acute (SF-36), section III of the Multidimensional Diabetes Questionnaire, the Summary of Diabetes Self-Care Activities questionnaire, and self-administered items relevant to the treatment and management of T2DM (eg, blood pressure and glycated hemoglobin [HbA1c]) at baseline and 3-7 days later. Once the DIAB-Q scale structure was determined, its test-retest reliability, construct validity, and known-groups validity were evaluated, and minimal clinically important change was estimated. In Stage I, the 23 respondents surveyed generally reported that the DIAB-Q was clear and comprehensive and endorsed questions as relevant to their intentions to engage in diabetes-related self-care activities. Most subjects in Stage II were male, Caucasian, and married. Mean age was 63 years. Factor analysis revealed six psychological constructs (Behavior, Planning, Intention, Perceived Behavioral Control, Attitude, and Subjective Norm). Test-retest reliability was acceptable (≥0.70) for all scales, except Perceived Behavioral Control. Construct validity was demonstrated based on correlations with diabetes-specific items/scales and the SF-36. Known-groups validity was confirmed for Behavior, Planning, and Intention when respondents were

  9. LHC Report: The machine under maintenance

    CERN Multimedia

    Katy Foraz for the LHC Team

    2012-01-01

    The LHC Christmas break started on 12 December. Since then, teams have been working hard to complete all the maintenance work planned to ensure the reliable operation of the LHC in 2012.   Installation of shielding at Point 1. The maintenance work is being carried out on key infrastructure such as the cooling, ventilation, electricity and safety systems. Maintenance work is being carried out not just in the LHC but also across the whole accelerator complex, which makes planning the work even more complicated. At the time of going to print, 50% of the cryogenics system maintenance has been finished, which, according to the schedule, will allow the LHC teams to start cooling down the first sectors next week to have the entire machine cold by the end of February. A lot of activity is going on in order to mitigate the effects of radiation on equipment installed in the LHC tunnel and underground areas during 2012 operation. To this end, teams have installed additional shielding at Point 1 (see ph...

  10. Transport package maintenance requirements and operations

    International Nuclear Information System (INIS)

    Tyacke, M.J.; Ball, L.J.; Ayers, A.L. Jr.; Hayes, G.R.; Anselmo, A.A.

    1988-01-01

    The NuPac 125-B rail cask, which transports the damaged core debris from Three Mile Island Unit 2 (TMI-2) to the Idaho National Engineering Laboratory (INEL), is the only new spent-fuel rail shipping cask to be licensed in the United States within the last decade. EG ampersand G Idaho, Inc. (EG ampersand G), acting on behalf of the US Department of Energy, is responsible for ensuring that those new casks and rail cars are properly maintained per regulatory requirements. Both the casks and rail cars have comprehensive in-service inspection and preventive maintenance programs, which are more involved than implied by the requirements. The TMI-2 shipping campaign is the most ambitious spent-fuel transport activity being conducted in the nuclear industry. The experience gained in this campaign, as it relates to maintenance of a transport system, should be of interest and have direct applicability to similar shipping activities planned in the years ahead

  11. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    pregnancy if they were married, educated, had dental insurance, previously used dental services when not pregnant, or had knowledge about the possible connection between oral health and pregnancy outcome8. The purpose of this study was to explore the factors determining good oral hygiene among pregnant women ...

  12. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    The perceptions of educational manag ers from previously disadvantaged primary and high schools in the Nelson Mandela Metropole regarding the issue of empowerment are outlined and the perceptions of educational managers in terms of various aspects of empowerment at different levels reflected. A literature study ...

  13. Management of choledocholithiasis after previous gastrectomy.

    Science.gov (United States)

    Anwer, S; Egan, R; Cross, N; Guru Naidu, S; Somasekar, K

    2017-09-01

    Common bile duct stones in patients with a previous gastrectomy can be a technical challenge because of the altered anatomy. This paper presents the successful management of two such patients using non-traditional techniques as conventional endoscopic retrograde cholangiopancreatography was not possible.

  14. Laboratory Grouping Based on Previous Courses.

    Science.gov (United States)

    Doemling, Donald B.; Bowman, Douglas C.

    1981-01-01

    In a five-year study, second-year human physiology students were grouped for laboratory according to previous physiology and laboratory experience. No significant differences in course or board examination performance were found, though correlations were found between predental grade-point averages and grouping. (MSE)

  15. The Diabetes Intention, Attitude, and Behavior Questionnaire: evaluation of a brief questionnaire to measure physical activity, dietary control, maintenance of a healthy weight, and psychological antecedents

    Directory of Open Access Journals (Sweden)

    Traina SB

    2016-02-01

    Full Text Available Shana B Traina,1 Susan D Mathias,2 Hilary H Colwell,2 Ross D Crosby,2–4 Charles Abraham5 1Patient-Reported Outcomes, Janssen Global Services, LLC, Raritan, NJ, USA; 2Health Outcomes Solutions, Winter Park, FL, USA; 3Biomedical Statistics & Methodology, Neuropsychiatric Research Institute, Fargo, ND, USA; 4Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA; 5Psychology Applied to Health, University of Exeter Medical School, Exeter, UK Background: This study assessed measurement properties of the 17-item Diabetes Intention, Attitude, and Behavior Questionnaire (DIAB-Q, which measures intention to engage in self-care behaviors, including following a diabetes diet and engaging in appropriate physical activity. Methods: The DIAB-Q includes questions based on the Theory of Planned Behavior. Items were developed using published literature, input from health care professionals, and qualitative research findings in patients with and without type 2 diabetes mellitus (T2DM. In Stage I of the study, 23 adults with T2DM were interviewed to evaluate the content and clarity of the DIAB-Q. In Stage II 1,015 individuals with T2DM completed the DIAB-Q and supplemental questionnaires, including the Short Form-36 acute (SF-36, section III of the Multidimensional Diabetes Questionnaire, the Summary of Diabetes Self-Care Activities questionnaire, and self-administered items relevant to the treatment and management of T2DM (eg, blood pressure and glycated hemoglobin [HbA1c] at baseline and 3–7 days later. Once the DIAB-Q scale structure was determined, its test–retest reliability, construct validity, and known-groups validity were evaluated, and minimal clinically important change was estimated. Results: In Stage I, the 23 respondents surveyed generally reported that the DIAB-Q was clear and comprehensive and endorsed questions as relevant to their intentions to engage in diabetes

  16. Integrin αIIb (CD41 plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta

    Directory of Open Access Journals (Sweden)

    Jean-Charles Boisset

    2013-04-01

    Integrins are transmembrane receptors that play important roles as modulators of cell behaviour through their adhesion properties and the initiation of signaling cascades. The αIIb integrin subunit (CD41 is one of the first cell surface markers indicative of hematopoietic commitment. αIIb pairs exclusively with β3 to form the αIIbβ3 integrin. β3 (CD61 also pairs with αv (CD51 to form the αvβ3 integrin. The expression and putative role of these integrins during mouse hematopoietic development is as yet unknown. We show here that hematopoietic stem cells (HSCs differentially express αIIbβ3 and αvβ3 integrins throughout development. Whereas the first HSCs generated in the aorta at mid-gestation express both integrins, HSCs from the placenta only express αvβ3, and most fetal liver HSCs do not express either integrin. By using αIIb deficient embryos, we show that αIIb is not only a reliable HSC marker but it also plays an important and specific function in maintaining the HSC activity in the mouse embryonic aorta.

  17. Reliability centered Maintenance (RCM) program for Chashma NPP (CHASNUPP)

    International Nuclear Information System (INIS)

    Khalid, S.; Khan, S.A.

    2000-01-01

    This paper describes the proposed Reliability Centered Maintenance (RCM) program for Chashma Nuclear Power Plant (CHASNUPP). Major steps are the identification of risk critical components and the implementation of RCM procedures. Identification of risk critical components is based upon the CHASNUPP level 1 PSA results (performed under IAEA TC Project PAK/9/019) which is near completion. The other requirements for implementation of RCM program is the qualitative analysis to be performed for identifying the dominant potential failure modes of each risk critical component and determination of the necessary maintenance activities, required to ensure reliable operation of the identified risk critical components. Implementation of RCM program for these components will lead to improvement in plant availability and safety together with reduction in the maintenance cost. Development - implementation of RCM program at this stage will help the CHASNUPP Maintenance department who is now developing the maintenance program - procedures for CHASNUPP. (author)

  18. Nuclear power plant maintenance scheduling dilemma: a genetic algorithm approach

    International Nuclear Information System (INIS)

    Mahdavi, M.H.; Modarres, M.

    2004-01-01

    There are huge numbers of components scheduled for maintenance when a nuclear power plant is shut down. Among these components, a number of them are safety related which their operability as well as reliability when plant becomes up is main concerns. Not performing proper maintenance on this class of components/system would impose substantial risk on operating the NPP. In this paper a new approach based on genetic algorithms is presented to optimize the NPP maintenance schedule during shutdown. following this approach the cost incurred by maintenance activities for each schedule is balanced with the risk imposed by the maintenance scheduling plan to the plant operation status when it is up. The risk model implemented in the GA scheduler as its evaluation function is developed on the basis of the probabilistic risk assessment methodology. the Ga optimizers itself is shown to be superior compared to other optimization methods such as the monte carlo technique

  19. Optimisation of distributed maintenance: Modelling and application to the multi-factory production

    International Nuclear Information System (INIS)

    Simeu-Abazi, Zineb; Ahmad, Alali Alhouaij

    2011-01-01

    This paper concerns the modelling and the cost evaluation of maintenance activities in a distributed context. In this work we study the particular case where the maintenance activities are executed by two workshops: a central maintenance workshop (CMW) and a mobile maintenance workshop (MMW). The CMW concerns the repairing process for the corrective maintenance and the MMW executes all preventive maintenance in several factories according to a defined scheduling. The aim is to take into account the resources (spare parts in the MMW) and maintenance actions for a given operating budget. A modular approach for modelling a multi-site structure is proposed to achieve the aim of improving the availability of facilities on production sites while minimising the cost of maintenance.

  20. Assessing maintenance contracts when preventive maintenance is outsourced

    International Nuclear Information System (INIS)

    Wu Shaomin

    2012-01-01

    In some companies, corrective maintenance is conducted in-house but preventive maintenance might be outsourced. This raises a need to optimise some parameters such as the number of contracts from a perspective of the equipment owner. This paper considers a maintenance policy for such a situation, analyses the roles of the parameters in a PM model, proposes approaches to defining bonus functions, and finally discusses special cases of both the PM policy and the bonus function. Numerical examples are also given to explore the impact of parameters on the expected lifecycle cost rate.

  1. 24 CFR 35.1015 - Visual assessment, paint stabilization, and maintenance.

    Science.gov (United States)

    2010-04-01

    ... require the incorporation of ongoing lead-based paint maintenance activities into regular building... stabilization, and maintenance. 35.1015 Section 35.1015 Housing and Urban Development Office of the Secretary... stabilization, and maintenance. If a dwelling unit receives Federal assistance under a program covered by this...

  2. TRUPACT-II Operating and Maintenance Instructions

    Energy Technology Data Exchange (ETDEWEB)

    Westinghouse Electric Corporation, Waste Isolation Division

    1999-12-31

    The purpose of this document is to provide the technical requirements for preparation for use, operation, inspection, and maintenance of a Transuranic Package Transporter Model II (TRUPACT-II) Shipping Package and directly related components. This document complies with the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP, the TRUPACT-II SARP shall govern. TRUPACT-II C of C number 9218 states, ''... each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.'' It further states, ''... each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the application.'' Chapter 9 of the TRUPACT-II SARP charges the Westinghouse Electric Corporation Waste Isolation Division (WID) with assuring that the TRUPACT-II is used in accordance with the requirements of the C of C. To meet this requirement and verify consistency of operations when loading and unloading the TRUPACT-II on the trailer, placing a payload in the packaging, unloading the payload from the packaging, or performing maintenance, the U.S. Department of Energy Carlsbad Area Office (U.S. DOE/CAO) finds it necessary to implement the changes that follow. This TRUPACT-II maintenance document represents a change to previous philosophy regarding site specific procedures for the use of the TRUPACT-II. This document details the instructions to be followed to consistently operate and maintain the TRUPACT-II. The intent of these instructions is to ensure that all users of the TRUPACT-II follow the same or equivalent instructions. Users may achieve this intent by any of the following methods: (1

  3. Nuclear instrument maintenance and technical training in Nuclear Energy Unit

    International Nuclear Information System (INIS)

    Mohamad Nasir Abdul Wahid

    1987-01-01

    Instrument maintenance service is a necessity in a Nuclear Research Institute, such as the Nuclear Energy Unit (NEU) to ensure the smooth running of our research activities. However, realising that maintenance back-up service for either nuclear or other scientific equipment is a major problem in developing countries such as Malaysia, NEU has set up an Instrumentation and Control Department to assist in rectifying the maintenance problem. Beside supporting in house activities in NEU, the Instrumentation and Control Department (I and C) is also geared into providing services to other organisations in Malaysia. This paper will briefly outline the activities of NEU in nuclear instrument maintenance as well as in technical training. (author)

  4. Maintenance Audit through Value Analysis Technique: A Case Study

    Science.gov (United States)

    Carnero, M. C.; Delgado, S.

    2008-11-01

    The increase in competitiveness, technological changes and the increase in the requirements of quality and service have forced a change in the design and application of maintenance, as well as the way in which it is considered within the managerial strategy. There are numerous maintenance activities that must be developed in a service company. As a result the maintenance functions as a whole have to be outsourced. Nevertheless, delegating this subject to specialized personnel does not exempt the company from responsibilities, but rather leads to the need for control of each maintenance activity. In order to achieve this control and to evaluate the efficiency and effectiveness of the company it is essential to carry out an audit that diagnoses the problems that could develop. In this paper a maintenance audit applied to a service company is developed. The methodology applied is based on the expert systems. The expert system by means of rules uses the weighting technique SMART and value analysis to obtain the weighting between the decision functions and between the alternatives. The expert system applies numerous rules and relations between different variables associated with the specific maintenance functions, to obtain the maintenance state by sections and the general maintenance state of the enterprise. The contributions of this paper are related to the development of a maintenance audit in a service enterprise, in which maintenance is not generally considered a strategic subject and to the integration of decision-making tools such as the weighting technique SMART with value analysis techniques, typical in the design of new products, in the area of the rule-based expert systems.

  5. Remote maintenance for DEMO

    International Nuclear Information System (INIS)

    Tremethick, T.; Bastow, R.; Iglesias, D.; Cooper, D.

    2015-01-01

    The EUROfusion Road-map to the Realisation of Fusion Energy outlines a European programme to produce concepts for a demonstration power plant, known as DEMO. It is the successor to the 13 billion ITER machine, currently being built in Cadarache, France. ITER will be the first fusion experiment to deliver a significant net output of energy. DEMO will build upon the experience gained in ITER and will demonstrate the technologies needed to deliver electricity to the grid. To be successful, a commercially viable power station requires high availability and must meet stringent nuclear safety requirements. However, due to neutron damage to materials, a fusion power station such as DEMO will also require the periodic exchange of the plasma facing components. To meet these requirements, components must be exchanged rapidly and in a highly controlled, safe manner. These requirements are met by the use of Remote Handling technologies, but present significant challenges due to the component scale and the hostile environment. RACE, the UKAEA's centre of excellence for remote handling, is leading a work package for EUROfusion to develop technologies for DEMO. The current scheme for blanket replacement is described in this poster. Blankets will be extracted through the upper ports on the tokamak using a cask system. This keeps the radioactive components isolated from the wider environment during maintenance. The vertical transporter is the major component of the interface cask. This has the capability to carry interchangeable end-effectors. Recovery and rescue scenarios are also improved due to the modular nature of the system and the access points created by the transport cask apertures

  6. Remote handling design for moderator-reflector maintenance in JSNS

    International Nuclear Information System (INIS)

    Teshigawara, Makoto; Aizawa, Hideyuki; Harada, Masahide; Kinoshita, Hidetaka; Meigo, Shinichiro; Maekawa, Fujio; Kaminaga, Masanori; Kato, Takashi; Ikeda, Yujiro

    2005-05-01

    This report introduces the present design status of remote-handling devices for activated and used components such as moderator and reflector in a spallation neutron source of the Material and Life Science Facility (MLF) at J-PARC (Japan Proton Accelerator Research Complex). The design concept and maintenance scenario are also mentioned. A key maintenance scenario adopts that the used components should be taken out from the MLF to the other storage facility after the volume reduction of them. Almost full remote handling is available to the maintenance work except for the connection/disconnection pipes of the cooling water. Remote handling for the cooling water system is under designing and it will be prepared before being significant radiation dose by accumulation of beryllium ( 7 Be) in future. Total six remote handling devices are used for moderator-reflector maintenance. They are also available to the proton beam window and muon target maintenance. Maintenance scenario is separated into two works. One is to replace used components to new ones during beam-stop and the other is dispose used components during beam operation. Required period of replacement work is estimated to be ∼15 days, on the other hand, the disposal work is ∼26 days after dry up work (∼30 days), respectively. Study of the maintenance scenario and the remote handling design brings about the reasonable procedures and period of the maintenance work. (author)

  7. Maintenance Support System Development for Maintenance Personnel in Nuclear Power Plants

    International Nuclear Information System (INIS)

    Yim, Ho Bin; Kim, In; Lee, Seung Min; Seong, Poong Hyun

    2009-01-01

    As plants or factories get old, the number of maintenance activities increases, and so does the necessity of maintenance itself. Industries have adopted the latest technologies such as RFID, wireless sensor networking, and augmented reality to develop systems which increase human performances as well as productivity. Due to safety related concerns, nuclear power industries have been reluctant to use these fancy technologies. However, from the economics point of view, it is necessary to take advantages of novel technologies. This empirical study considers not only ergonomics view, but also the economics view when building maintenance support systems. This paper introduces brief features of five subsystems which were built to reduce human errors and advantages when each system successfully reduces those human errors

  8. Digital maintenance field technology for the maintenance of nuclear power plant

    International Nuclear Information System (INIS)

    Sato, Tomomasa; Asama, Hajime; Kita, Nobuyuki; Numano, Masayoshi

    2002-01-01

    This paper proposes a concept of 'Digital Maintenance Field Technology', which enables human beings and working robots making fully use of the necessary information for maintenance activity not only in any location of the maintenance field (seamless in location) but also in any moment from the past to the future (seamless in time) and in any format in presenting to human (seamless in semantics). The paper points out the following three essential components of the technology: 1) 'Digital Field Construction Technology', 2) 'Digital Field Archival Technology' and 3) 'Digital Field Presentation Technology'. The necessary capabilities are extracted and our approaches and state of the art of realizing these capabilities are introduced in addition to present the state of the art of home application example. The future extension is also illustrated. (author)

  9. Previously unknown organomagnesium compounds in astrochemical context

    OpenAIRE

    Ruf, Alexander

    2018-01-01

    We describe the detection of dihydroxymagnesium carboxylates (CHOMg) in astrochemical context. CHOMg was detected in meteorites via ultrahigh-resolving chemical analytics and represents a novel, previously unreported chemical class. Thus, chemical stability was probed via quantum chemical computations, in combination with experimental fragmentation techniques. Results propose the putative formation of green-chemical OH-Grignard-type molecules and triggered fundamental questions within chemica...

  10. [Placental complications after a previous cesarean section].

    Science.gov (United States)

    Milosević, Jelena; Lilić, Vekoslav; Tasić, Marija; Radović-Janosević, Dragana; Stefanović, Milan; Antić, Vladimir

    2009-01-01

    The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complication development. The research was conducted at the Clinic of Gynecology and Obstetrics in Nis covering 10-year-period (from 1995 to 2005) with 32358 deliveries, 1280 deliveries after a previous cesarean section, 131 cases of placenta previa and 118 cases of placental abruption. The experimental groups was presented by the cases of placenta previa or placental abruption with prior cesarean section in obstetrics history, opposite to the control group having the same conditions but without a cesarean section in medical history. The incidence of placenta previa in the control group was 0.33%, opposite to the 1.86% incidence after one cesarean section (pcesarean sections and as high as 14.28% after three cesarean sections in obstetric history. Placental abruption was recorded as placental complication in 0.33% pregnancies in the control group, while its incidence was 1.02% after one cesarean section (pcesarean sections. The difference in the incidence of intrapartal hysterectomy between the group with prior cesarean section (0.86%) and without it (0.006%) shows a high statistical significance (pcesarean section is an important risk factor for the development of placental complications.

  11. Maintenance and Revitalization of Gallo

    DEFF Research Database (Denmark)

    Nolan, J. Shaun

    2018-01-01

    This chapter examines the current state of maintenance and revitalization of eastern Brittany’s Oïl language variety, Gallo. Following a description of the sociolinguistic context of regional languages in France today, this chapter focuses on maintenance and revitalization efforts for Gallo. Gallo...... promotion organizations comprising teachers, linguists, enthusiasts, and activists are working hard at a local and regional level to ensure that there is a greater awareness of the existence of this language variety and to foster an appreciation of the importance of its maintenance and revitalization...

  12. Maintenance of radiation monitoring systems

    International Nuclear Information System (INIS)

    Aoyama, Kei

    2001-01-01

    As the safety and quality of atomic power facilities are more strongly required, the reliability improvement and preventive maintenance of radiation monitoring systems are important. This paper describes the maintenance of radiation monitoring systems delivered by Fuji Electric and the present status of preventive maintenance technology. Also it introduces the case that we developed a fault diagnosis function adopting a statistics technique and artificial intelligence (AI) and delivered a radiation monitoring system including this function. This system can output a fault analysis result and a countermeasure from the computer in real time. (author)

  13. Innovative techniques in maintenance training

    International Nuclear Information System (INIS)

    Soileau, J.B.; Blackwell, C.; Rackos, N.; Elmer, L.B.

    1991-01-01

    Performance based training has its beginning with a Job and Task Analysis (JTA), and culminates with the presentation of the developed training material. For optimum training effectiveness, a post training feedback mechanism is utilized to update and/or upgrade material content. A Job Task Analysis uses subject matter experts and supporting documentation to define the skills and knowledge necessary to perform functions from total position responsibilities to the simplest tasks, depending on desired results. Once skills and knowledge are defined, decisions on needed curriculum can be made including objectives, exams, and training settings (classroom, lab, or job site). This focused curriculum and the determination of best training settings are innovations of the performanced based training system. Past training experience has illustrated that a baseline level of classroom training acts as a catalyst for optimum hands-on training. The trainee exits the training phase able to do the job proficiently. This provides the training customer with quality training with minimum investment. Maintenance Training at Comanche Peak Steam Electric Station (CPSES) integrates the knowledge and skill needs by providing the individual with focused classroom presentations followed by sufficient laboratory time to practice actual task activities. Labs are configured to represent plant equipment and work environment to the maximum extent possible and duplicate in-plant work orders and procedures are used. This allows actions to be analyzed and corrective feedback given as necessary. As an added benefit, any mistakes made during training has minimal, if any, impact on plant performance

  14. Melatonin-Stimulated Triacylglycerol Breakdown and Energy Turnover under Salinity Stress Contributes to the Maintenance of Plasma Membrane H+-ATPase Activity and K+/Na+ Homeostasis in Sweet Potato.

    Science.gov (United States)

    Yu, Yicheng; Wang, Aimin; Li, Xiang; Kou, Meng; Wang, Wenjun; Chen, Xianyang; Xu, Tao; Zhu, Mingku; Ma, Daifu; Li, Zongyun; Sun, Jian

    2018-01-01

    Melatonin (MT) is a multifunctional molecule in animals and plants and is involved in defense against salinity stress in various plant species. In this study, MT pretreatment was simultaneously applied to the roots and leaves of sweet potato seedlings [ Ipomoea batatas (L.) Lam.], which is an important food and industry crop worldwide, followed by treatment of 150 mM NaCl. The roles of MT in mediating K + /Na + homeostasis and lipid metabolism in salinized sweet potato were investigated. Exogenous MT enhanced the resistance to NaCl and improved K + /Na + homeostasis in sweet potato seedlings as indicated by the low reduced K + content in tissues and low accumulation of Na + content in the shoot. Electrophysiological experiments revealed that exogenous MT significantly suppressed NaCl-induced K + efflux in sweet potato roots and mesophyll tissues. Further experiments showed that MT enhanced the plasma membrane (PM) H + -ATPase activity and intracellular adenosine triphosphate (ATP) level in the roots and leaves of salinized sweet potato. Lipidomic profiling revealed that exogenous MT completely prevented salt-induced triacylglycerol (TAG) accumulation in the leaves. In addition, MT upregulated the expression of genes related to TAG breakdown, fatty acid (FA) β-oxidation, and energy turnover. Chemical inhibition of the β-oxidation pathway led to drastic accumulation of lipid droplets in the vegetative tissues of NaCl-stressed sweet potato and simultaneously disrupted the MT-stimulated energy state, PM H + -ATPase activity, and K + /Na + homeostasis. Results revealed that exogenous MT stimulated TAG breakdown, FA β-oxidation, and energy turnover under salinity conditions, thereby contributing to the maintenance of PM H + -ATPase activity and K + /Na + homeostasis in sweet potato.

  15. Melatonin-Stimulated Triacylglycerol Breakdown and Energy Turnover under Salinity Stress Contributes to the Maintenance of Plasma Membrane H+–ATPase Activity and K+/Na+ Homeostasis in Sweet Potato

    Science.gov (United States)

    Yu, Yicheng; Wang, Aimin; Li, Xiang; Kou, Meng; Wang, Wenjun; Chen, Xianyang; Xu, Tao; Zhu, Mingku; Ma, Daifu; Li, Zongyun; Sun, Jian

    2018-01-01

    Melatonin (MT) is a multifunctional molecule in animals and plants and is involved in defense against salinity stress in various plant species. In this study, MT pretreatment was simultaneously applied to the roots and leaves of sweet potato seedlings [Ipomoea batatas (L.) Lam.], which is an important food and industry crop worldwide, followed by treatment of 150 mM NaCl. The roles of MT in mediating K+/Na+ homeostasis and lipid metabolism in salinized sweet potato were investigated. Exogenous MT enhanced the resistance to NaCl and improved K+/Na+ homeostasis in sweet potato seedlings as indicated by the low reduced K+ content in tissues and low accumulation of Na+ content in the shoot. Electrophysiological experiments revealed that exogenous MT significantly suppressed NaCl-induced K+ efflux in sweet potato roots and mesophyll tissues. Further experiments showed that MT enhanced the plasma membrane (PM) H+–ATPase activity and intracellular adenosine triphosphate (ATP) level in the roots and leaves of salinized sweet potato. Lipidomic profiling revealed that exogenous MT completely prevented salt-induced triacylglycerol (TAG) accumulation in the leaves. In addition, MT upregulated the expression of genes related to TAG breakdown, fatty acid (FA) β-oxidation, and energy turnover. Chemical inhibition of the β-oxidation pathway led to drastic accumulation of lipid droplets in the vegetative tissues of NaCl-stressed sweet potato and simultaneously disrupted the MT-stimulated energy state, PM H+–ATPase activity, and K+/Na+ homeostasis. Results revealed that exogenous MT stimulated TAG breakdown, FA β-oxidation, and energy turnover under salinity conditions, thereby contributing to the maintenance of PM H+–ATPase activity and K+/Na+ homeostasis in sweet potato. PMID:29535758

  16. Melatonin-Stimulated Triacylglycerol Breakdown and Energy Turnover under Salinity Stress Contributes to the Maintenance of Plasma Membrane H+–ATPase Activity and K+/Na+ Homeostasis in Sweet Potato

    Directory of Open Access Journals (Sweden)

    Yicheng Yu

    2018-02-01

    Full Text Available Melatonin (MT is a multifunctional molecule in animals and plants and is involved in defense against salinity stress in various plant species. In this study, MT pretreatment was simultaneously applied to the roots and leaves of sweet potato seedlings [Ipomoea batatas (L. Lam.], which is an important food and industry crop worldwide, followed by treatment of 150 mM NaCl. The roles of MT in mediating K+/Na+ homeostasis and lipid metabolism in salinized sweet potato were investigated. Exogenous MT enhanced the resistance to NaCl and improved K+/Na+ homeostasis in sweet potato seedlings as indicated by the low reduced K+ content in tissues and low accumulation of Na+ content in the shoot. Electrophysiological experiments revealed that exogenous MT significantly suppressed NaCl-induced K+ efflux in sweet potato roots and mesophyll tissues. Further experiments showed that MT enhanced the plasma membrane (PM H+–ATPase activity and intracellular adenosine triphosphate (ATP level in the roots and leaves of salinized sweet potato. Lipidomic profiling revealed that exogenous MT completely prevented salt-induced triacylglycerol (TAG accumulation in the leaves. In addition, MT upregulated the expression of genes related to TAG breakdown, fatty acid (FA β-oxidation, and energy turnover. Chemical inhibition of the β-oxidation pathway led to drastic accumulation of lipid droplets in the vegetative tissues of NaCl-stressed sweet potato and simultaneously disrupted the MT-stimulated energy state, PM H+–ATPase activity, and K+/Na+ homeostasis. Results revealed that exogenous MT stimulated TAG breakdown, FA β-oxidation, and energy turnover under salinity conditions, thereby contributing to the maintenance of PM H+–ATPase activity and K+/Na+ homeostasis in sweet potato.

  17. Aircraft Maintenance Planning Using Fuzzy Critical Path Analysis

    Directory of Open Access Journals (Sweden)

    Omer Atli

    2012-06-01

    Full Text Available Aircraft's availability is certainly one of the most important features of modern avionic industry. The aircraft maintenance scheduling is one of the major decisions an airline has to make during its operation. When an aircraft maintenance event occurs, the overhaul tasks management process requires the execution of all tasks to perform and has to guarantee the on-time aircraft delivery and the respect of the daily flight schedule. Though maintenance scheduling comes as an end stage in an airline operation, it has potential for cost savings. Maintenance scheduling is an easily understood but difficult to solve problem. Given a flight schedule with aircraft assigned to it, the aircraft maintenance-scheduling problem is to determine which aircraft should fly which segment and when and where each aircraft should undergo different levels of maintenance check. The objective of this paper is to minimize the aircraft maintenance planning time and to show how to create a plan with critical path analyses under fuzzy environment. We use trapezoidal fuzzy numbers for activity times and Activity-on-Node (AON representation in fuzzy critical path method (FCPM. An illustrative example is given for Aircraft Gas Turbine Engine Repair/Overhaul problem.

  18. Maintenance training - who needs it?

    International Nuclear Information System (INIS)

    Adams, H.

    1988-01-01

    The author's job responsibilities at Rocky Flats include preventive maintenance, training to meet the needs of maintenance personnel, training for special projects such as welding and metal fabrication, and reporting to the manager of plant maintenance engineers. He notes that many old-line manufacturers are becoming high-tech companies, emphasizing the role of automation in production and quality control. He lists and discusses changes at Rocky Flats, along with the attendant preventive maintenance program the changes necessitate. He observes estimates that training costs to companies over the next 10 years will exceed 10% of their revenues - that in 1986, American companies spent $210 billion on training at all levels. But, if you think training is expensive, try placing a cost on ignorance. 9 figures

  19. Preventative maintenance program for bridges.

    Science.gov (United States)

    2015-07-01

    The Kentucky Transportation Cabinets (KYTC) bridge inventory is rapidly aging. As such, the Cabinet : needs to identify and implement relevant preventative maintenance (PM) actions to extend the useful : service lives of those structures. Maintena...

  20. Real Time Maintenance Approval and Required IMMT Coordination

    Science.gov (United States)

    Burchell, S.

    2016-01-01

    Payloads are assessed for nominal operations. Payload Developers have the option of performing a maintenance hazard assessment (MHA) for potential maintenance activities. When POIC (Payload Operations and Integration Center) Safety reviews an OCR calling for a maintenance procedure, we cannot approve it without a MHA. If no MHA exists, we contact MER (Mission Evaluation Room) Safety. Depending on the nature of the problem, MER Safety has the option to: Analyze and grant approval themselves; Direct the payload back to the ISRP (Integrated Safety Review Panel); Direct the payload to the IMMT (Increment Mission Management Team).

  1. Manual on maintenance of systems and components important to safety

    International Nuclear Information System (INIS)

    1986-01-01

    The Manual should serve as guidance at the plant management level for the maintenance of systems and components important to safety. It includes a detailed description of management systems, administrative controls and procedures. The Annexes contain examples of documents and practices adopted by Operating Organizations of some Member States. It is not the intention of this Manual to address the technical problem of how to maintain a particular component but rather to cover the programmatic aspects of maintenance. It also contains some aspects of surveillance and verification activities. The Manual makes only general statements about radiation protection provisions in connection with maintenance; detailed guidance can be found in other IAEA documents

  2. Oak Ridge Research Reactor shutdown maintenance and surveillance

    International Nuclear Information System (INIS)

    Coleman, G.H.; Laughlin, D.L.

    1990-10-01

    The Department of Energy ordered the Oak Ridge Research Center Reactor to be placed in permanent shutdown on July 14, 1987. Maintenance activities, both mechanical and instrument, were essentially routine in nature. The performance of the instrumentation for the facility was satisfactory, and maintenance required is provided. The performance of the process system was satisfactory, and maintenance required is indicated. The results of efficiency tests of the various gaseous-waste filters have been summarized and preparations for transfer of the facility to the remedial action program is also indicated

  3. Differential effects of cognitive load on emotion: Emotion maintenance versus passive experience.

    Science.gov (United States)

    DeFraine, William C

    2016-06-01

    Two separate lines of research have examined the effects of cognitive load on emotional processing with similar tasks but seemingly contradictory results. Some research has shown that the emotions elicited by passive viewing of emotional images are reduced by subsequent cognitive load. Other research has shown that such emotions are not reduced by cognitive load if the emotions are actively maintained. The present study sought to compare and resolve these 2 lines of research. Participants either passively viewed negative emotional images or maintained the emotions elicited by the images, and after a delay rated the intensity of the emotion they were feeling. Half of trials included a math task during the delay to induce cognitive load, and the other half did not. Results showed that cognitive load reduced the intensity of negative emotions during passive-viewing of emotional images but not during emotion maintenance. The present study replicates the findings of both lines of research, and shows that the key factor is whether or not emotions are actively maintained. Also, in the context of previous emotion maintenance research, the present results support the theoretical idea of a separable emotion maintenance process. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  4. The long view for nuclear plant maintenance

    International Nuclear Information System (INIS)

    Moore, T.

    1991-01-01

    This article discusses a strategic, anticipatory approach to maintenance as the key to the long-term viability of today's nuclear power plants. As many as 20 plants around the country now have life-cycle management (LCM) programs in place - integrated, forward-looking preventive maintenance and monitoring programs that preserve the plant's material condition and extend economical operation. Besides reducing the need for 'pounds of cure' decades in the future, LCM programs can produce significant near-term gains in plant performance and are valuable in addressing license renewal concerns. EPRI is supporting the industry's LCM activities with research on age-related degradation mechanisms, development of economic evaluation tools for applying LCM approaches, and assistance with life-cycle evaluations of major plant systems, structures, and components at selected utilities

  5. Context Awareness And Railway Maintenance

    OpenAIRE

    Villarejo, Roberto; Galar, Diego; Johansson, Carl-Anders; Menendez, Manuel; Perales, Numan

    2014-01-01

    A railway is an extremely complex system requiring maintenancedecision support systems to gather data from many disparatesources. These sources include traditional maintenanceinformation like condition monitoring or work records, as well astraffic information, given the criticality of maintenance inavoiding traffic disruptions and the need to minimise the trackpossession time for maintenance.A methodology is required if maintainers are to understand thedata as a whole. Context engines try to ...

  6. Towards a maintenance semantic architecture.

    OpenAIRE

    Hedi Karray, Mohamed; Chebel-Morello, Brigitte; Zerhouni, Noureddine

    2009-01-01

    International audience; Technological and software progress with the evolution of processes within company have highlighted the need to evolve systems of maintenance process from autonomous systems to cooperative and sharing information system based on software platform. However, this need gives rise to various maintenance platforms. The first part of this study investigates the different types of existing industrial platforms and characterizes them compared to two criteria namely : informati...

  7. Books average previous decade of economic misery.

    Science.gov (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  8. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    Erna Kinsey

    school system from department level to the level of individual learner. .... H02: There is no relationship between teacher empowerment and key values and ... Importance of activity. Figure 1 Staff empowerment matrix (Steyn, 2001:154) formation and decision back for review or approval. Short and Geer (1997:141) and ...

  9. Induced vaginal birth after previous caesarean section

    Directory of Open Access Journals (Sweden)

    Akylbek Tussupkaliyev

    2016-11-01

    Full Text Available Introduction The rate of operative birth by Caesarean section is constantly rising. In Kazakhstan, it reaches 27 per cent. Research data confirm that the percentage of successful vaginal births after previous Caesarean section is 50–70 per cent. How safe the induction of vaginal birth after Caesarean (VBAC remains unclear. Methodology The studied techniques of labour induction were amniotomy of the foetal bladder with the vulsellum ramus, intravaginal administration of E1 prostaglandin (Misoprostol, and intravenous infusion of Oxytocin-Richter. The assessment of rediness of parturient canals was conducted by Bishop’s score; the labour course was assessed by a partogram. The effectiveness of labour induction techniques was assessed by the number of administered doses, the time of onset of regular labour, the course of labour and the postpartum period and the presence of complications, and the course of the early neonatal period, which implied the assessment of the child’s condition, described in the newborn development record. The foetus was assessed by medical ultrasound and antenatal and intranatal cardiotocography (CTG. Obtained results were analysed with SAS statistical processing software. Results The overall percentage of successful births with intravaginal administration of Misoprostol was 93 per cent (83 of cases. This percentage was higher than in the amniotomy group (relative risk (RR 11.7 and was similar to the oxytocin group (RR 0.83. Amniotomy was effective in 54 per cent (39 of cases, when it induced regular labour. Intravenous oxytocin infusion was effective in 94 per cent (89 of cases. This percentage was higher than that with amniotomy (RR 12.5. Conclusions The success of vaginal delivery after previous Caesarean section can be achieved in almost 70 per cent of cases. At that, labour induction does not decrease this indicator and remains within population boundaries.

  10. Computerization of operation and maintenance for nuclear power plants

    International Nuclear Information System (INIS)

    1995-07-01

    This report provides a resource for computerization of activities in plant operation and maintenance. Experience gained from design and implementation of various computer systems around the world is described. The material may be useful as a guide to modification and upgrading of existing plants as well as design and engineering of new plants. It should be particularly of interest to managers and engineers who are engaged in planning, bidding, specifying or designing computer systems for operation and maintenance applications. Refs, figs and tabs

  11. Simulator configuration maintenance

    International Nuclear Information System (INIS)

    2006-01-01

    Requirements and recommendations of this section defines NPP personnel activity aimed to the provision of the simulator configuration compliance with the current configuration of the power-generating unit-prototype, standard and technical requirements and describe a monitoring procedure for a set of simulator software and hardware, training, organizational and technical documents

  12. Status of maintenance in the US nuclear power industry 1985. Volume 2. Description of programs and practices

    International Nuclear Information System (INIS)

    1986-06-01

    This report documents a review of the status of maintenance programs and practices in the US commercial nuclear power industry. The purpose of this review is to establish a baselines reference for evaluating the effectiveness of future industry activities in maintenance. Two methods used to collect progammatic data. First, a Maintenance Review Protocol was used during site visits to eight selected power plants to collect in-depth maintenance program information. Second, a Maintenance Questionnaire was filled out by NRC Resident Inspectors regarding maintenance programs at their plant. The protocol and questionnaire contained items regarding five broad categories of maintenance: (1) organization and administration, (2) facilities and equipment, (3) procedures, (4) personnel, and (5) work control. The study found that there is wide variability in industry maintenance programs. However, the industry is currently undergoing changes in maintenance practices, and adherence to INPO and NUMARC guidance in maintenance may bring about more systematically developed program practices

  13. Surgical treatment of breast cancer in previously augmented patients.

    Science.gov (United States)

    Karanas, Yvonne L; Leong, Darren S; Da Lio, Andrew; Waldron, Kathleen; Watson, James P; Chang, Helena; Shaw, William W

    2003-03-01

    The incidence of breast cancer is increasing each year. Concomitantly, cosmetic breast augmentation has become the second most often performed cosmetic surgical procedure. As the augmented patient population ages, an increasing number of breast cancer cases among previously augmented women can be anticipated. The surgical treatment of these patients is controversial, with several questions remaining unanswered. Is breast conservation therapy feasible in this patient population and can these patients retain their implants? A retrospective review of all breast cancer patients with a history of previous augmentation mammaplasty who were treated at the Revlon/UCLA Breast Center between 1991 and 2001 was performed. During the study period, 58 patients were treated. Thirty patients (52 percent) were treated with a modified radical mastectomy with implant removal. Twenty-eight patients (48 percent) underwent breast conservation therapy, which consisted of lumpectomy, axillary lymph node dissection, and radiotherapy. Twenty-two of the patients who underwent breast conservation therapy initially retained their implants. Eleven of those 22 patients (50 percent) ultimately required completion mastectomies with implant removal because of implant complications (two patients), local recurrences (five patients), or the inability to obtain negative margins (four patients). Nine additional patients experienced complications resulting from their implants, including contracture, erosion, pain, and rupture. The data illustrate that breast conservation therapy with maintenance of the implant is not ideal for the majority of augmented patients. Breast conservation therapy with explantation and mastopexy might be appropriate for rare patients with large volumes of native breast tissue. Mastectomy with immediate reconstruction might be a more suitable choice for these patients.

  14. Croatian Language Maintenance in Canada

    Directory of Open Access Journals (Sweden)

    Ivana Petrović

    2017-01-01

    , and participants were instructed that they could use whichever language they felt most comfortable with. Most first-generation participants responded in Croatian, and most second-generation participants responded in English. The average age of first-generation participants was 58.6 (SD = 12.14 and the average age of second-generation participants was 33.1 (SD = 10.06. There were more females in both groups, 58.2% in the first-generation group and 54.5% in the second generation group. As far as the differences in education level between the two groups are cocerned, second-generation participants were mostly better educated than first-generation participants. There are numerous social, demographic and economic factors that could contribute to minority language maintenance or that could bring about a shift to the majority language; moreover, many models have been proposed in order to account for differences in language maintenance between various ethnic groups (cf. Clyne, 2003. For instance, Giles, Bourhis and Taylor (1977 introduced the theoretical construct of ethnolinguistic vitality. Ethnolinguistic vitality is defined as “that which makes a group likely to behave as a distinctive and active collective entity in intergroup settings” (Giles, Bourhis and Taylor, 1977: 308. They argue that groups with high ethnolinguistic vitality are more likely to survive as recognizable and unified entities, and maintain their language. On the other hand, in groups with low ethnolinguistic vitality it is more likely that language shift will occur. According to Giles, Bourhis and Taylor (1977, there are three main types of variables that influence the vitality of a group: status variables, demographic variables, and institutional support variables. This paper focuses on demographic factors, especially on census language data and historical comparisons, which could give an indication of ethnolinguistic vitality and language stability of the Croatian community in Canada. Demographic

  15. Maintenance and Safety Practices of Escalator in Commercial Buildings

    Science.gov (United States)

    Afida Isnaini Janipha, Nurul; Nur Aina Syed Alwee, Sharifah; Ariff, Raihan Mohd; Ismail, Faridah

    2018-02-01

    The escalator is very crucial to transport a person from one place to another. Nevertheless, there are many cases recorded the accidents in relation to escalator. These may occur due to lack of maintenance which leads to systems breakdown, poor safety practices, wear and tear, users’ negligence and others. Thus, proper maintenance systems need to be improvised to prevent and reduce escalator accident in future. This research was aimed to determine the escalator maintenance activities and safety practices in a commercial building. Three case studies were selected within Selangor area. Semi-structured interviews were conducted for collecting data from these three case studies. To achieve the aim of this research, the study was carried out on the maintenance activities, safety practices and cost related to escalator maintenance. As one of the important means of access in building, it is very crucial to increase effectiveness of escalator particularly in commercial building. It is expected that readers will get clear information on the maintenance activities and safety practices of escalator in commercial building.

  16. Potential of Computerized Maintenance Management System in Facilities Management

    Directory of Open Access Journals (Sweden)

    Noor Farisya Azahar

    2014-07-01

    Full Text Available For some time it has been clear that managing buildings or estates has been carried out in the context of what has become known as facilities management. British Institute of Facilities Management defined facilities management is the integration of multi-disciplinary activities within the built environment and the management of their impact upon people and the workplace. Effective facilities management is vital to the success of an organisation by contributing to the delivery of its strategic and operational objectives. Maintenance of buildings should be given serious attention before (stage design, during and after a building is completed. But total involvement in building maintenance is after the building is completed and during its operations. Residents of and property owners require their building to look attractive, durable and have a peaceful indoor environment and efficient. The objective of the maintenance management system is to stream line the vast maintenance information system to improve the productivity of an industrial plant. a good maintenance management system makes equipment and facilities available. This paper will discuss the fundamental steps of maintenance management program and Computerized Maintenance Management System (CMMS

  17. Integrated preventive maintenance and production decisions for imperfect processes

    International Nuclear Information System (INIS)

    Nourelfath, Mustapha; Nahas, Nabil; Ben-Daya, Mohamed

    2016-01-01

    This paper integrates production, maintenance, and quality for an imperfect process in a multi-period multi-product capacitated lot-sizing context. The production system is modeled as an imperfect machine, whose the status is considered to be either in-control or out-of-control. When the machine is out of control, it produces a fraction of nonconforming items. During each period, this machine is inspected and imperfect preventive maintenance activities are simultaneously performed to reduce its age, proportional to the preventive maintenance level. The objective is to minimize the total cost, while satisfying the demand for all products. Our optimization model allows for a joint selection of the optimal values of production plan, and the maintenance policy, while taking into account quality related costs. A solution algorithm is developed and illustrative numerical examples are presented. It is found that the increase in PM level leads to reductions in quality control costs. Furthermore, if the cost of performing PM is high to the point where it is not compensated for by reductions in the quality related costs, then performing PM is not justifiable. Finally, using non-periodic preventive maintenance with the possibility of different preventive maintenance levels may result in an improvement of the total cost. - Highlights: • We integrate production, maintenance, and quality. • We evaluate all the expected costs. • Our model allows for a joint selection of the optimal values. • A solution algorithm is developed. • Increasing PM level will decrease quality control costs.

  18. An application of PSA techniques to on-line maintenance program. A feasibility study of maintenance strategy during plant operation using PSA techniques

    International Nuclear Information System (INIS)

    Onoue, Akira; Kojima, Shigeo; Aoi, Sadanori

    1998-01-01

    This study confirms an on-line maintenance possibility for a Japanese NPP from a plant risk management point of view. One-line maintenance has already been planned and executed in some NPPs in the United States. The problem preceding on-line maintenance is how to keep a certain level of plant safety with out of service condition, safety-related systems and components, during maintenance. Deterministically, the technical specification defines unplanned maintenance periods of safety related standby systems. Probabilistically, this principle is able to be verified by utilizing PSA technology. In this study a PSA method for Japanese PWR plants is applied to improve plant availability, and to investigate safety issues associated with on-line maintenance strategy, system configuration, management and financial advantage regarding Japanese plant constraints. On-line maintenance is one of the risk management activities to improve safety and manpower workload during shutdown. As a result of this study, core damage frequency can show that on-line maintenance of some safety related systems is able to be performed and that of other safety related systems, not. On-line maintenance for Japanese NPPs utilizing risk method, will be introducing maintenance programs during power operation, like as performed in the United States. It will be important to prepare guidelines for on-line maintenance principles for further risk management programs. (author)

  19. On-line maintenance at Cofrentes NPP

    International Nuclear Information System (INIS)

    Suarez, J.; Moreno, M.

    2000-01-01

    Cofrentes NPP (CNPP) has developed a Level 1 PSA with the following scope: analysis of internal events, with the reactor initially operating at power; internal and external flooding risk analysis; internal fire risk analysis; reliability analysis of the containment heat removal and containment isolation systems. Level 1 CNPP-PSA results reveal that total core damage frequency in CNPP is less than other similar BWR/6 plants. The CNPP-PSA related activities and applications being carried out currently are: prioritization of motor operated valves related to GL-89/10; complementary analysis for exemption to some 10CFR50 App. J requirements; Q-List grading; risk-informed IST program; reliability-centered maintenance; maintenance rule support; on-line maintenance support; off-line risk-monitor development; PSA applicability to the 10CFR50 App. R requirements, analysis of the frequency of miss-oriented fuel bundle event, adjusting of MAAP 3.0B, revision 10, on VAX and PC; acquisition of MAAP 4; development of Level1/Level2-PSA interface; seismic site categorization for the IPEEE; etc. (author)

  20. Maintenance proficiency evaluation test bank

    International Nuclear Information System (INIS)

    Maier, Loran

    2003-01-01

    The Maintenance Proficiency Evaluation Test Bank (MPETB) is an Electric Power Research Institute- (EPRJ-) operated, utility-sponsored means of developing, maintaining, and disseminating secure, high-quality written and performance maintenance proficiency tests. EPRTs charter is to ensure that all tests and test items that go into the Test Bank have been validated, screened for reliability, and evaluated to high standards of psychometric excellence. Proficiency tests of maintenance personnel.(mechanics, electricians, and instrumentation and control [I and C] technicians) are most often used to determine if an experienced employee is capable of performing maintenance tasks without further training. Such tests provide objective evidence for decisions to exempt an employee from what, for the employee, is unnecessary training. This leads to considerable savings in training costs and increased productivity because supervisors can assign personnel to tasks at which their competence is proven. The ultimate objective of proficiency evaluation is to ensure that qualified maintenance personnel are available to meet the maintenance requirements of the plant Numerous task-specific MPE tests (both written and performance) have been developed and validated using the EPRI MPE methodology by the utilities participating in the MPETB project A task-specific MPE consists of a multiple-choice written examination and a multi-step performance evaluation that can be used to assess an individual's present knowledge and skill level for a given maintenance task. The MPETB contains MPEs and test items for the mechanical, electrical, and I and C classifications that are readily available to participating utilities. Presently, utilities are placing emphasis on developing MPEs to evaluate outage-related maintenance tasks that demonstrate the competency and qualifications of plant and contractor personnel before the start of outage work. Utilities are also using the MPE methodology and process to