Accidental sequences associated with the containment of the pressurized water nuclear installation - INAP

International Nuclear Information System (INIS)

Natacci, Faustina Beatriz; Correa, Francisco

2002-01-01

The analysis of accidental sequences associated with the Containment is one of the most important tasks during the development of the Probabilistic Safety Assessment (PSA) of nuclear plants mainly because of its importance on the mitigation of consequences of severe postulated accident initiating events. This paper presents a first approach of the Containment analysis of the INAP identifying failures and events that can compromise its performance, and outlining accidental sequences and Containment end states. The initial plant damage states, which are the input for this study, are based on the event trees developed in the PSA level 1 for the INAP. It should be emphasized that since this PSA is still in a preliminary stage it is subjected to further completion. Consequently, the Containment analysis shall also be revised in order to incorporate, in an extension as complete as possible, all initial plant damage states, the corresponding event trees, and the related Containment end states. Finally, it can be concluded that the evaluation of the qualitative analysis presented herein allows a concise and broad knowledge of the qualitative analysis presented herein allows a concise and broad knowledge of the development of accidental sequences related to the Containment of the INAP. (author)

Comportamiento de los accidentes laborales

Directory of Open Access Journals (Sweden)

Miguel Gómez Vital

1999-01-01

Full Text Available Se realiza una valoración sobre la situación de la accidentalidad en centros de trabajo de la provincia de Villa Clara de 1993 a 1997. El total de accidentes registrados fue de 12 522. Últimamente han disminuido y su índice de incidencia. En el último año se redujo el promedio de días perdidos, pero el índice de gravedad alcanzó la cifra mayor. Se insiste en el cumplimiento del programa de prevención y reducción de accidentes laborales.The situation of the occupational accidents that occurred in the province of Villa Clara from 1993 to 1997 was assessed. 12 522 accidents were registered during that periods. A decrease of these accidents and of their incidence rate has been observed lately. The average of lost days was reduced during the last year, out the severity index reached the highest figure. Emphasis is made on the importance of fulfilling the program of prevention and reduction of occupational accidents.

Genetic Damage Induced by Accidental Environmental Pollutants

Directory of Open Access Journals (Sweden)

Beatriz Pérez-Cadahía

2006-01-01

Full Text Available Petroleum is one of the main energy sources worldwide. Its transport is performed by big tankers following some established marine routes. In the last 50 years a total amount of 37 oil tankers have given rise to great spills in different parts of the world, Prestige being the last one. After the accident, a big human mobilisation took place in order to clean beaches, rocks and fauna, trying to reduce the environmental consequences of this serious catastrophe. These people were exposed to the complex mixture of compounds contained in the oil. This study aimed at determine the level of environmental exposure to volatile organic compounds (VOC, and the possible damage induced on the population involved in the different cleaning tasks by applying the genotoxicity tests sister chromatid exchanges (SCE, micronucleus (MN test, and comet assay. Four groups of individuals were included: volunteers (V, hired manual workers (MW, hired high-pressure cleaner workers (HPW and controls. The higher VOC levels were associated with V environment, followed by MW and lastly by HPW, probably due to the use of high-pressure cleaners. Oil exposure during the cleaning tasks has caused an increase in the genotoxic damage in individuals, the comet assay being the most sensitive biomarker to detect it. Sex, age and tobacco consumption have shown to influence the level of genetic damage, while the effect of using protective devices was less noticeable than expected, perhaps because the kind used was not the most adequate.

Accidental exposure with X-ray diffraction equipment

International Nuclear Information System (INIS)

Montanez, O.; Blanco, D.

1991-01-01

The shutter on one of the windows of an X-ray diffraction apparatus was accidentally left open, exposing the worker to the radiation. The worker was wearing a dosimeter film, which was processed immediately to evaluate the potential risk. It was determined that the exposure rate was 350 Roentgen/minute on the skin surface, with corrections being made for the worker's thin clothing. It was concluded that in spite of the worker receiving a relative high dose, it did not reach the threshold value for producing deterministic effects such as cataracts, erythema, and skin damage

Investigación de accidentes y análisis de fallas de barreras preventivas; Accident’s Investigation and Preventive Barriers flaws analysis

Directory of Open Access Journals (Sweden)

Jacinto B Hernández Lavín

2011-02-01

Full Text Available En Cuba, como en el resto del mundo,  la existencia de leyes y regulaciones estatales, obligan a que lasempresas productivas y de servicios cuenten con un sistema de prevención de accidentes y enfermedadesprofesionales que, a partir del control de los riesgos existentes en cada puesto de trabajo, permita laboraren un ambiente seguro. En este artículo se explican las técnicas y procedimientos establecidos en la UNEpara la investigación de accidentes laborales. In Cuba, like in the rest of the world, the existence of Laws and state Regulations, they force to productivecompanies and services, they have a prevention system to avoid the accidents and professional illnessesthat, starting from the control of the existent risks in each work position, allow working in a sure atmosphere.In this article the techniques and procedures are explained, applied in the Electric Union (UNE, for thelabor accident investigation.

Social evaluation of intentional, truly accidental, and negligently accidental helpers and harmers by 10-month-old infants.

Science.gov (United States)

Woo, Brandon M; Steckler, Conor M; Le, Doan T; Hamlin, J Kiley

2017-11-01

Whereas adults largely base their evaluations of others' actions on others' intentions, a host of research in developmental psychology suggests that younger children privilege outcome over intention, leading them to condemn accidental harm. To date, this question has been examined only with children capable of language production. In the current studies, we utilized a non-linguistic puppet show paradigm to examine the evaluation of intentional and accidental acts of helping or harming in 10-month-old infants. In Experiment 1 (n=64), infants preferred intentional over accidental helpers but accidental over intentional harmers, suggestive that by this age infants incorporate information about others' intentions into their social evaluations. In Experiment 2 (n=64), infants did not distinguish "negligently" accidental from intentional helpers or harmers, suggestive that infants may find negligent accidents somewhat intentional. In Experiment 3 (n=64), we found that infants preferred truly accidental over negligently accidental harmers, but did not reliably distinguish negligently accidental from truly accidental helpers, consistent with past work with adults and children suggestive that humans are particularly sensitive to negligently accidental harm. Together, these results imply that infants engage in intention-based social evaluation of those who help and harm accidentally, so long as those accidents do not stem from negligence. Copyright © 2017 Elsevier B.V. All rights reserved.

Alleviation of acute radiation damages by post-irradiation treatments

International Nuclear Information System (INIS)

Kurishita, A.; Ono, T.

1992-01-01

Radiation induced hematopoietic and gastro-intestinal damages in mice were tried to alleviate experimentally by post-treatment. Combined treatment of OK-432 and aztreonam clearly prevented the radiation induced sepsis and elevated the survival rate in mice; the survival was 80% in the OK-432 plus aztreonam group while it was 55% in the group treated with OK-432 alone and 0% with saline. Irsogladine maleate, an anti-ulcer drug, increased the survival rate of jejunal crypt stem cells with a clear dose-related trend. The D 0 for irsogladine maleate was 2.8 Gy although it was 2.3 Gy for saline, These findings suggest that some conventional drugs are effective for radiation induced hematopoietic and gastro-intestinal damages and the possibility that they can be applied for people exposed to radiation accidentally. (author)

Accidental Durotomy in Minimally Invasive Transforaminal Lumbar Interbody Fusion: Frequency, Risk Factors, and Management

Directory of Open Access Journals (Sweden)

Jan-Helge Klingler

2015-01-01

Full Text Available Purpose. To assess the frequency, risk factors, and management of accidental durotomy in minimally invasive transforaminal lumbar interbody fusion (MIS TLIF. Methods. This single-center study retrospectively investigates 372 patients who underwent MIS TLIF and were mobilized within 24 hours after surgery. The frequency of accidental durotomies, intraoperative closure technique, body mass index, and history of previous surgery was recorded. Results. We identified 32 accidental durotomies in 514 MIS TLIF levels (6.2%. Analysis showed a statistically significant relation of accidental durotomies to overweight patients (body mass index ≥25 kg/m2; P=0.0493. Patient age older than 65 years tended to be a positive predictor for accidental durotomies (P=0.0657. Mobilizing patients on the first postoperative day, we observed no durotomy-associated complications. Conclusions. The frequency of accidental durotomies in MIS TLIF is low, with overweight being a risk factor for accidental durotomies. The minimally invasive approach seems to minimize durotomy-associated complications (CSF leakage, pseudomeningocele because of the limited dead space in the soft tissue. Patients with accidental durotomy can usually be mobilized within 24 hours after MIS TLIF without increased risk. The minimally invasive TLIF technique might thus be beneficial in the prevention of postoperative immobilization-associated complications such as venous thromboembolism. This trial is registered with DRKS00006135.

Micronutrient special issue: Coenzyme Q10 requirements for DNA damage prevention

International Nuclear Information System (INIS)

Schmelzer, Constance; Döring, Frank

2012-01-01

Coenzyme Q 10 (CoQ 10 ) is an essential component for electron transport in the mitochondrial respiratory chain and serves as cofactor in several biological processes. The reduced form of CoQ 10 (ubiquinol, Q 10 H 2 ) is an effective antioxidant in biological membranes. During the last years, particular interest has been grown on molecular effects of CoQ 10 supplementation on mechanisms related to DNA damage prevention. This review describes recent advances in our understanding about the impact of CoQ 10 on genomic stability in cells, animals and humans. With regard to several in vitro and in vivo studies, CoQ 10 provides protective effects on several markers of oxidative DNA damage and genomic stability. In comparison to the number of studies reporting preventive effects of CoQ 10 on oxidative stress biomarkers, CoQ 10 intervention studies in humans with a direct focus on markers of DNA damage are limited. Thus, more well-designed studies in healthy and disease populations with long-term follow up results are needed to substantiate the reported beneficial effects of CoQ 10 on prevention of DNA damage.

Accidental Beam Losses and Protection in the LHC

Science.gov (United States)

Schmidt, R.; Working Group On Machine Protection

2005-06-01

At top energy (proton momentum 7 TeV/c) with nominal beam parameters, each of the two LHC proton beams has a stored energy of 350 MJ threatening to damage accelerator equipment in case of accidental beam loss. It is essential that the beams are properly extracted onto the dump blocks in case of failure since these are the only elements that can withstand full beam impact. Although the energy stored in the beams at injection (450 GeV/c) is about 15 times smaller compared to top energy, the beams must still be properly extracted in case of large accidental beam losses. Failures must be detected at a sufficiently early stage and initiate a beam dump. Quenches and power converter failures will be detected by monitoring the correct functioning of the hardware systems. In addition, safe operation throughout the cycle requires the use of beam loss monitors, collimators and absorbers. Ideas of detection of fast beam current decay, monitoring of fast beam position changes and monitoring of fast magnet current changes are discussed, to provide the required redundancy for machine protection.

Accidental Beam Losses and Protection in the LHC

International Nuclear Information System (INIS)

Schmidt, R.; Wenninger, J.

2005-01-01

At top energy (proton momentum 7 TeV/c) with nominal beam parameters, each of the two LHC proton beams has a stored energy of 350 MJ threatening to damage accelerator equipment in case of accidental beam loss. It is essential that the beams are properly extracted onto the dump blocks in case of failure since these are the only elements that can withstand full beam impact. Although the energy stored in the beams at injection (450 GeV/c) is about 15 times smaller compared to top energy, the beams must still be properly extracted in case of large accidental beam losses. Failures must be detected at a sufficiently early stage and initiate a beam dump. Quenches and power converter failures will be detected by monitoring the correct functioning of the hardware systems. In addition, safe operation throughout the cycle requires the use of beam loss monitors, collimators and absorbers. Ideas of detection of fast beam current decay, monitoring of fast beam position changes and monitoring of fast magnet current changes are discussed, to provide the required redundancy for machine protection

[The accidental detection of apical periodontitis].

Science.gov (United States)

Wesselink, P R

2011-04-01

Accidental detection of an asymptomatic apical periodontitis raises the question whether this lesion should be treated or not. Arguments favouring treatment are that the inflammation may cause pain in the future, may enlarge or may negatively affect the host's resistance. Reasons for not treating may be that treatment weakens the tooth, may cause iatrogenic damage and that treatment is expensive and burdensome for the patient and does not lead in all cases to complete healing. Scientific evidence supporting either choice, whether treating the lesion or not, is lacking. In making such decisions, therefore, personal judgments by the patient and the dentist concerning the impact on the quality of life of the patient play an important role.

Benefits of invasion prevention: Effect of time lags, spread rates, and damage persistence

Science.gov (United States)

Rebecca S. Epanchin-Niell; Andrew M. Liebhold

2015-01-01

Quantifying economic damages caused by invasive species is crucial for cost-benefit analyses of biosecurity measures. Most studies focus on short-term damage estimates, but evaluating exclusion or prevention measures requires estimates of total anticipated damages from the time of establishment onward. The magnitude of such damages critically depends on the timing of...

Micronutrient special issue: Coenzyme Q{sub 10} requirements for DNA damage prevention

Energy Technology Data Exchange (ETDEWEB)

Schmelzer, Constance, E-mail: schmelzer@fbn-dummerstorf.de [Leibniz Institute for Farm Animal Biology (FBN), Nutritional Physiology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf (Germany); Doering, Frank [University of Kiel, Institute of Human Nutrition and Food Science, Molecular Prevention, Heinrich-Hecht-Platz 10, 24118 Kiel (Germany)

2012-05-01

Coenzyme Q{sub 10} (CoQ{sub 10}) is an essential component for electron transport in the mitochondrial respiratory chain and serves as cofactor in several biological processes. The reduced form of CoQ{sub 10} (ubiquinol, Q{sub 10}H{sub 2}) is an effective antioxidant in biological membranes. During the last years, particular interest has been grown on molecular effects of CoQ{sub 10} supplementation on mechanisms related to DNA damage prevention. This review describes recent advances in our understanding about the impact of CoQ{sub 10} on genomic stability in cells, animals and humans. With regard to several in vitro and in vivo studies, CoQ{sub 10} provides protective effects on several markers of oxidative DNA damage and genomic stability. In comparison to the number of studies reporting preventive effects of CoQ{sub 10} on oxidative stress biomarkers, CoQ{sub 10} intervention studies in humans with a direct focus on markers of DNA damage are limited. Thus, more well-designed studies in healthy and disease populations with long-term follow up results are needed to substantiate the reported beneficial effects of CoQ{sub 10} on prevention of DNA damage.

Detecting spatiotemporal clusters of accidental poisoning mortality among Texas counties, U.S., 1980 – 2001

Directory of Open Access Journals (Sweden)

Harris Ann

2004-10-01

Full Text Available Abstract Background Accidental poisoning is one of the leading causes of injury in the United States, second only to motor vehicle accidents. According to the Centers for Disease Control and Prevention, the rates of accidental poisoning mortality have been increasing in the past fourteen years nationally. In Texas, mortality rates from accidental poisoning have mirrored national trends, increasing linearly from 1981 to 2001. The purpose of this study was to determine if there are spatiotemporal clusters of accidental poisoning mortality among Texas counties, and if so, whether there are variations in clustering and risk according to gender and race/ethnicity. The Spatial Scan Statistic in combination with GIS software was used to identify potential clusters between 1980 and 2001 among Texas counties, and Poisson regression was used to evaluate risk differences. Results Several significant (p Conclusion The findings of the present study provide evidence for the existence of accidental poisoning mortality clusters in Texas, demonstrate the persistence of these clusters into the present decade, and show the spatiotemporal variations in risk and clustering of accidental poisoning deaths by gender and race/ethnicity. By quantifying disparities in accidental poisoning mortality by place, time and person, this study demonstrates the utility of the spatial scan statistic combined with GIS and regression methods in identifying priority areas for public health planning and resource allocation.

ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application

Directory of Open Access Journals (Sweden)

Michael Froehle

2012-01-01

Full Text Available Mepivacaine is a potent local anaesthetic and used for infiltration and regional anaesthesia in adults and pediatric patients. Intoxications with mepivacaine affect mainly the CNS and the cardiovascular system. We present a case of accidental intravenous mepivacaine application and intoxication of an infant resulting in seizure, broad complex bradyarrhythmia, arterial hypotension and finally cardiac arrest. The patient could be rescued by prolonged resuscitations and a rapid initiation of ECMO and survived without neurological damage. The management strategies of this rare complication including promising other treatment options with lipid emulsions are discussed.

77 FR 19799 - Pipeline Safety: Pipeline Damage Prevention Programs

Science.gov (United States)

2012-04-02

... noted ``when the oil pipeline industry developed the survey for its voluntary spill reporting system...) [cir] The American Public Gas Association (APGA) [cir] The Association of Oil Pipelines (AOPL) [cir... the contrary, all 50 states in the United States have a law designed to prevent excavation damage to...

Accidental falls in hospitalized children: an analysis of the vulnerabilities linked to the presence of caregivers.

Science.gov (United States)

Bagnasco, A; Sobrero, M; Sperlinga, L; Tibaldi, L; Sasso, L

2010-06-01

This study stemmed from the data gathered by a research conducted by the coordinator of the Department of Healthcare Services and a group of nurses involved in a research on accidental falls in hospitalized children at the "G. Gaslini" Children's Hospital and Scientific Research Institute in Genoa, Italy. The first retrospective study evaluated the accidental falls in hospitalized children referred to the three-year period 2003-2006, while the second perspective study, referred to the trimester March-May 2007, found that the main cause of falls in children was parent's distraction. The method adopted in the first phase of our study was a proactive risk analysis (The Basics of Healthcare Failure Mode and Effect Analysis), identified in the first place by the VA National Centre for Patient Safety and applied to the "Child and parent hospital admission process". This proactive risk analysis has proven to be very effective in preventing the risk of accidental falls in hospitalized children through effective communication and educational interventions. The second phase of our study consisted of two Focus Groups for accidental traumatic events. The analysis of the results of the study showed how effective communication is instrumental, not only to have a better awareness of the children and their parents during their stay in hospital, but also to implement educational sessions on prevention to reduce the risk of accidental traumatic events. The present study contributes to improve safety and the quality of care by motivating nurses to keep their attention high on falls in hospitalized children, by monitoring and the development of new risk assessment tools.

A study on fire design accidental loads for aluminum safety helidecks

Directory of Open Access Journals (Sweden)

Sang Jin Kim

2016-11-01

Full Text Available The helideck structure must satisfy the safety requirements associated with various environmental and accidental loads. Especially, there have been a number of fire accidents offshore due to helicopter collision (take-off and/or landing in recent decades. To prevent further accidents, a substantial amount of effort has been directed toward the management of fire in the safety design of offshore helidecks. The aims of this study are to introduce and apply a procedure for quantitative risk assessment and management of fires by defining the fire loads with an applied example. The frequency of helicopter accidents are considered, and design accidental levels are applied. The proposed procedures for determining design fire loads can be efficiently applied in offshore helideck development projects.

Patterns of accidental deaths in Kuwait: a retrospective descriptive study from 2003-2009.

Science.gov (United States)

Al-Kandary, Nadia; Al-Waheeb, Salah

2015-03-28

Accidents are a preventable cause of death. Unfortunately it accounts for a large number of deaths in many societies. In Kuwait, road traffic accidents (RTA) is the leading cause of death in young people. The study investigated the patterns of accidental deaths in Kuwait, one of the Gulf States which incorporates a wide variety of multi-ethnic communities. The study was retrospective from 2003-2009. Data of forensic cases were collected from the general department of criminal evidence (GDCE) in the ministry of interior (MOI).We attempted to find out causes of accidental death and the prevelance of each cause. Furthermore, the relationship of demographic factors (eg. Age, sex, marital status and nationality) with each cause of accidental death in Kuwait were studied. The material of this study constituted a total of 4886 reported accidental deaths referred for Medico-legal examination. Road traffic accidents was by far the most prevalent cause of death (64.6%) followed by fall from height (13.1%). Poisoning and mine explosions were amongst the least common causes. The government of Kuwait needs to take strong measures to promote safety in the workplace and households by educational campaigns.

La prevención de accidentes (3

Directory of Open Access Journals (Sweden)

Chinchilla, M.

1966-04-01

Full Text Available The financial loss due to working accidents is very substantial, quite apart from the actual loss of human lives. Hence avoiding these accidents is a most important matter. The accident index in the various industries shows a rate of increase that is larger than should be the case in proportion to the development of the industries concerned, and the larger number of employees. The fact that these indexes are smaller in many countries, however, shows that these accidents can be considerably reduced if suitable measures are taken to avoid them. In chapter 2 of our magazine, issue no. 178, a variety of reasons were discussed that may originate accidents, although these causes are not directly linked to the accident itself. In this article mention is made of some of the measures that can be taken in the handling of cutting and welding equipment, and also of inflammable liquids, to prevent possible accidents.El peso de los accidentes de trabajo sobre la economía supone cantidades muy grandes que, independientemente del inestimable valor de una vida humana, realzan la importancia de la prevención de accidentes. Los índices de accidentes muestran en diferentes industrias un crecimiento mayor de lo que debería corresponder proporcionalmente, habida cuenta del crecimiento laboral. El hecho de que en distintos países los índices sean inferiores, demuestra que se pueden conseguir buenos frutos si se concede primordial importancia a que los trabajos se realicen con las debidas medidas de seguridad. En el Capítulo 2, número 178 de esta Revista, se detallaron diversas causas que pueden originar un accidente sin estar ligadas en forma directa con una tarea determinada. En el presente trabajo se indican algunas de las medidas que deben observarse en el manejo de los equipos de soldadura y corte, así como en el transvase de líquidos inflamables.

Prevention of damage and 'residual risk' in nuclear power laws

International Nuclear Information System (INIS)

Greipl, C.

1992-01-01

The concept of prevention of damage within the framework of nuclear power laws includes averting danger for the protection of third parties and preventing risks for the partial protection of third parties with the proviso that still a desire to use the concept 'residual risk' in addition, it should be limited, on the grounds of what can be reasonably expected, to those risks which cannot be reduced any further by the government, i.e. to risks which the public in general and third parties ('actually') must accept. In the future, questions regarding safety systems should be taken into account exclusively withing the context of 'what is necessary for protection against damage in keeping with the latest developments in science and technology' and not at the discretion of the law in denying permission according to Article 7 Paragraph 2 Atomic Energy Law. (orig.) [de

Converting Hangar High Expansion Foam Systems to Prevent Cockpit Damage: Full-Scale Validation Tests

Science.gov (United States)

2017-09-01

AFCEC-CO-TY-TR-2018-0001 CONVERTING HANGAR HIGH EXPANSION FOAM SYSTEMS TO PREVENT COCKPIT DAMAGE: FULL-SCALE VALIDATION TESTS Gerard G...manufacturer, or otherwise does not constitute or imply its endorsement, recommendation , or approval by the United States Air Force. The views and...09-2017 Final Test Report May 2017 Converting Hangar High Expansion Foam Systems to Prevent Cockpit Damage: Full-Scale Validation Tests N00173-15-D

Control of radiation sources and general regulations for accidental situations

International Nuclear Information System (INIS)

Slimani, A.

1998-01-01

In order to prevent accidents caused by application of radiation sources the Tunisian O.N.P.C. established straightforward strategy made up of 3 phases: prevention, planning and intervention. Civil Protection conducts prevention studies of all radiation sources by examining normal application conditions as well as possible accidental situations. It keeps up with scientific, technical and statistical aspects of radiation risks, elaborates specific plans and programs for intervention operations and cooperates with administrative and security services as well as international organisations. The O.N.P.C. established a model intervention plan based on observation (according to preliminary information), evaluation of the situation (according to the head of operation) intervention (specialized units) and post intervention (testing of personnel)

La prevención de accidentes

Directory of Open Access Journals (Sweden)

Chinchilla, M.

1966-02-01

Full Text Available Working accidents have a high moral and material impact, and are often easy to avoid, at least in about half the cases. Hence it is most important that campaigns for the reduction of these accidents should be correctly planned, so that such campaigns should not merely result in additional expense, and in a lowering of staff morale, when workers find themselves operating in an unpleasant and dangerous activity. In addition to special requirements, which may be studied in a later paper, and which must necessarily cover a very wide number of alternative cases, there are circumstances of a general nature, such as financial and moral consequences, and psychological repercussions, which influence the prevention of accidents and are the subject of this article.La notable repercusión moral y material que tienen los accidentes de trabajo y la fácil evitación de los mismos, por lo menos en la mitad de los casos, hacen sumamente importante que las campañas de prevención de accidentes estén bien orientadas y proyectadas, para evitar que se traduzcan, únicamente, en un gasto más y en una disminución de la moral del personal, al ver, éste, que está situado en medio de un ambiente desagradable y peligroso. Además de las normas particulares, que pueden ser objeto de otro trabajo posterior, y que han de ser forzosamente amplias, debido a la multiplicidad de factores que intervienen, hay, sin embargo, unas consideraciones de carácter general, tales como repercusiones económicas y morales y factores psicológicos que influyen en la prevención de accidentes y que son objeto del presente artículo.

Acute Renal Failure following Accidental Potassium Bromate ...

African Journals Online (AJOL)

Accidental poisoning is common in children. Potassium bromate is a commonly used additive and raising agent in many edibles particularly bread, a staple food worldwide, yet its accidental poisoning has hitherto, not been documented in Nigeria. We report an unusual case of acute renal failure following accidental ...

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.

Science.gov (United States)

Hill, Sarah J; Mordes, Daniel A; Cameron, Lisa A; Neuberg, Donna S; Landini, Serena; Eggan, Kevin; Livingston, David M

2016-11-29

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron dysfunction disease that leads to paralysis and death. There is currently no established molecular pathogenesis pathway. Multiple proteins involved in RNA processing are linked to ALS, including FUS and TDP43, and we propose a disease mechanism in which loss of function of at least one of these proteins leads to an accumulation of transcription-associated DNA damage contributing to motor neuron cell death and progressive neurological symptoms. In support of this hypothesis, we find that FUS or TDP43 depletion leads to increased sensitivity to a transcription-arresting agent due to increased DNA damage. Thus, these proteins normally contribute to the prevention or repair of transcription-associated DNA damage. In addition, both FUS and TDP43 colocalize with active RNA polymerase II at sites of DNA damage along with the DNA damage repair protein, BRCA1, and FUS and TDP43 participate in the prevention or repair of R loop-associated DNA damage, a manifestation of aberrant transcription and/or RNA processing. Gaining a better understanding of the role(s) that FUS and TDP43 play in transcription-associated DNA damage could shed light on the mechanisms underlying ALS pathogenesis.

Techniques for preventing damage to high power laser components

International Nuclear Information System (INIS)

Stowers, I.F.; Patton, H.G.; Jones, W.A.; Wentworth, D.E.

1977-09-01

Techniques for preventing damage to components of the LASL Shiva high power laser system were briefly presented. Optical element damage in the disk amplifier from the combined fluence of the primary laser beam and the Xenon flash lamps that pump the cavity was discussed. Assembly and cleaning techniques were described which have improved optical element life by minimizing particulate and optically absorbing film contamination on assembled amplifier structures. A Class-100 vertical flaw clean room used for assembly and inspection of laser components was also described. The life of a disk amplifier was extended from less than 50 shots to 500 shots through application of these assembly and cleaning techniques

Self-Administered Ethanol Enema Causing Accidental Death

Directory of Open Access Journals (Sweden)

Thomas Peterson

2014-01-01

Full Text Available Excessive ethanol consumption is a leading preventable cause of death in the United States. Much of the harm from ethanol comes from those who engage in excessive or hazardous drinking. Rectal absorption of ethanol bypasses the first pass metabolic effect, allowing for a higher concentration of blood ethanol to occur for a given volume of solution and, consequently, greater potential for central nervous system depression. However, accidental death is extremely rare with rectal administration. This case report describes an individual with klismaphilia whose death resulted from acute ethanol intoxication by rectal absorption of a wine enema.

Prevention of Severe Hypoglycemia-Induced Brain Damage and Cognitive Impairment with Verapamil.

Science.gov (United States)

Jackson, David A; Michael, Trevin; Vieira de Abreu, Adriana; Agrawal, Rahul; Bortolato, Marco; Fisher, Simon J

2018-05-03

People with insulin-treated diabetes are uniquely at risk for severe hypoglycemia-induced brain damage. Since calcium influx may mediate brain damage, we tested the hypothesis that the calcium channel blocker, verapamil, would significantly reduce brain damage and cognitive impairment caused by severe hypoglycemia. Ten-week-old Sprague-Dawley rats were randomly assigned to one of three treatments; 1) control hyperinsulinemic (200 mU.kg -1 min -1 ) euglycemic (80-100mg/dl) clamps (n=14), 2) hyperinsulinemic hypoglycemic (10-15mg/dl) clamps (n=16), or 3) hyperinsulinemic hypoglycemic clamps followed by a single treatment with verapamil (20mg/kg) (n=11). As compared to euglycemic controls, hypoglycemia markedly increased dead/dying neurons in the hippocampus and cortex, by 16-fold and 14-fold, respectively. Verapamil treatment strikingly decreased hypoglycemia-induced hippocampal and cortical damage, by 87% and 94%, respectively. Morris Water Maze probe trial results demonstrated that hypoglycemia induced a retention, but not encoding, memory deficit (noted by both abolished target quadrant preference and reduced target quadrant time). Verapamil treatment significantly rescued spatial memory as noted by restoration of target quadrant preference and target quadrant time. In summary, a one-time treatment with verapamil following severe hypoglycemia prevented neural damage and memory impairment caused by severe hypoglycemia. For people with insulin treated diabetes, verapamil may be a useful drug to prevent hypoglycemia-induced brain damage. © 2018 by the American Diabetes Association.

The Effects of Mitigation Measures on Flood Damage Prevention in Korea

Directory of Open Access Journals (Sweden)

Cheol-Hee Son

2015-12-01

Full Text Available This study analyzed the characteristics of flood damages and the effects of structural and non-structural flood damage mitigation measures in Korea. First, a theoretical discussion of the structural and non-structural measures to mitigate flood damages was used to select the variables and devise the hypotheses. An analysis was conducted using the Auto-Regressive Integrated Moving-Average (ARIMA time series methodology, Korean socioeconomic data, and damage characteristics of major flood events. The effects of flood damage mitigation measures on the extent of flood damages were assessed using an intervention time series model. The major findings were that the intervention effects of structural and non-structural measures were statistically significant from 1958 to 2013 (a period of 55 years and that while the former were ineffective at mitigating flood damages, the latter were successful in doing so. Based on the above findings, policy suggestions for future flood damage mitigation measures in Korea were offered. For structural measures, the government should manage its existing facilities, recover ecosystems of damaged rivers, and devise mitigation measures for urban areas. For non-structural measures, the government should enhance its flood forecasting capacity, revise laws related to flood control and prevention, and update and rationalize land-use plans.

Can ebselen prevent cisplatin-induced ovarian damage?

Science.gov (United States)

Soyman, Zeynep; Uzun, Hafize; Bayindir, Nihan; Esrefoglu, Mukaddes; Boran, Birtan

2018-06-01

The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen-a seleno-organic compound with antioxidant and antiinflammatory properties-vis-à-vis CP-induced ovarian damage. Twenty-eight adult female rats were divided into four study groups. Group 1 received no treatment. The rats in Groups 2, 3, and 4 were intraperitoneally administered CP (2 mg/kg/day) twice per week, for 5 weeks. Those in Group 2 received 0.3 ml saline (0.9% NaCl) intraperitoneally 60 min before each CP treatment, while those in Group 3 received 0.2 ml dimethyl sulfoxide (DMSO) and 0.3 ml saline intraperitoneally 60 min before each CP treatment. The rats in Group 4 were pretreated with an intraperitoneal injection of 15 mg/kg/day ebselen 60 min before each CP treatment. Ovarian tissue malondialdehyde (MDA), total nitric oxide (NOx), glutathione (GSH), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and catalase levels, as well as histopathological damage scores (HDSs) and serum antimullerian hormone (AMH) levels, were assessed. Cu/Zn-SOD and GSH levels were significantly higher, and MDA and NOx levels significantly lower, in Group 4 than in Groups 2 and 3. Pretreatment with ebselen significantly improved serum AMH levels, relative to Groups 2 and 3. Additionally, HDS values were significantly lower in Group 4 than in Groups 2 and 3. Our results from using an experimental rat model of CP chemotherapy suggest that ebselen use may ameliorate ovarian damage by preventing oxidative injury.

Radiative accidental matter

Energy Technology Data Exchange (ETDEWEB)

Sierra, D. Aristizabal [IFPA, Dép. AGO, Université de Liège,Bât B5, Sart Tilman B-4000 Liège 1 (Belgium); Universidad Técnica Federico Santa María - Departamento de Física,Casilla 110-V, Avda. España 1680, Valparaíso (Chile); Simoes, C.; Wegman, D. [IFPA, Dép. AGO, Université de Liège,Bât B5, Sart Tilman B-4000 Liège 1 (Belgium)

2016-07-25

Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that μ→eγ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below 5×10{sup 5} GeV, a value (naturally) assured by the radiative suppression mechanism. Sizeable τ→μγ branching fractions within SuperKEKB sensitivity are possible for lower lepton-number breaking scales. We thus point out that these scenarios can be tested not only in direct searches but also in lepton flavor-violating experiments.

A descriptive study of accidental skeletal injuries and non-accidental skeletal injuries of child maltreatment.

Science.gov (United States)

Ghanem, Maha A H; Moustafa, Tarek A; Megahed, Haidy M; Salama, Naglaa; Ghitani, Sara A

2018-02-01

Lack of awareness and recognition of child maltreatment is the major reason behind underreporting. All victims often interact with the health care system for routine or emergency care. In several research works, non-accidental fractures are the second most common injury in maltreated children and it is represented up to one-third of cases. To determine the incidence of different types of accidental and non-accidental skeletal injuries among children, estimate the severity of injuries according to the modified injury severity score and to determine the degree of fractures either closed or opened (Gustiloe-Anderson open fracture classification). Moreover, identifying fractures resulting from child abuse and neglect. This aimed for early recognition of non-accidental nature of fractures in child maltreatment that can prevent further morbidity and mortality. A descriptive study was carried out on all children (109) with skeletal injuries who were admitted to both Main Alexandria and El-Hadara Orthopedic and Traumatology University Hospitals during six months. History, physical examination and investigations were done for the patients. A detailed questionnaire was taken to diagnose child abuse and neglect. Gustiloe-Anderson open fracture classification was used to estimate the degree of open fractures. Out of 109 children, twelve cases (11%) were categorized as child maltreatment. One case was physical abuse, eight cases (7.3%) were child neglect and three cases (2.8%) were labour exploitation. Road traffic accidents (RTA) was the commonest cause of skeletal injuries followed by falling from height. Regarding falls, they included 4 cases of stair falls in neglected children and another four cases of falling from height (balcony/window). The remaining 36 cases of falls were accidental. The skeletal injuries were in the form of fractures in 99 cases, dislocation in two cases, both fracture and/or dislocation in three cases, and bone deformity from brachial plexus injury

[THREE CASES OF ACCIDENTAL AUTO-INJECTION OF ADRENALINE].

Science.gov (United States)

Yanagida, Noriyuki; Iikura, Katsuhito; Ogura, Kiyotake; Wang, Ling-jen; Asaumi, Tomoyuki; Sato, Sakura; Ebisawa, Motohiro

2015-12-01

Reports on accidental auto-injection of adrenaline are few. We encountered three cases of accidental injection of adrenaline. In this study, we have examined and reported the clinical courses and symptoms of our cases. CASE 1 involved a female physician in her 50s who had attended an explanatory meeting on auto-injection of adrenaline. She mistook EpiPen® to be the EpiPen trainer and accidentally injected herself with 0.3 mg EpiPen®. Her systolic/diastolic pressure peaked at 7 min to reach 144/78 mmHg and decreased to 120/77 mmHg at 14 min. Except for palpitation after 7 min, the only subjective symptom was local pain at the injection site. CASE 2 was noted in a 6-year-old boy. He accidentally pierced his right forefinger with 0.15 mg EpiPen®, and after 20 min, his right forefinger was swollen. The swelling improved 80 min after the accidental injection. CASE 3 was noted in a 4-year-old girl. She accidentally injected herself with 0.15 mg EpiPen®. Her systolic/diastolic pressure peaked at 23 min to reach 123/70 mmHg and decreased to 96/86 mmHg at 28 min. Severe adverse effects of accidental auto-injection of adrenaline were not observed in these three cases. Our findings suggest that while handling adrenaline auto-injectors, we should keep in mind the possibility of accidental injection.

Effect of a Multi-Level Education Intervention Model on Knowledge and Attitudes of Accidental Injuries in Rural Children in Zunyi, Southwest China

Directory of Open Access Journals (Sweden)

Bo-Ling Cao

2015-04-01

Full Text Available Objective: To explore the effect of a school-family-individual (SFI multi-level education intervention model on knowledge and attitudes about accidental injuries among school-aged children to improve injury prevention strategies and reduce the incidence of pediatric injuries. Methods: The random sample of rural school-aged children were recruited by using a multistage, stratified, cluster sampling method in Zunyi, Southwest China from 2012 to 2014, and 2342 children were randomly divided into intervention and control groups. Then children answered a baseline survey to collect knowledge and attitude scores (KAS of accidental injuries. In the intervention group, children, their parents/guardians and the school received a SFI multi-level education intervention, which included a children’s injury-prevention poster at schools, an open letter about security instruction for parents/guardians and multiple-media health education (Microsoft PowerPoint lectures, videos, handbooks, etc. to children. Children in the control group were given only handbook education. After 16 months, children answered a follow-up survey to collect data on accidental injury types and accidental injury-related KAS for comparing the intervention and control groups and baseline and follow-up data. Results: The distribution of gender was not significantly different while age was different between the baseline and follow-up survey. At baseline, the mean KAS was lower for the intervention than control group (15.37 ± 3.40 and 18.35 ± 5.01; p < 0.001. At follow-up, the mean KAS was higher for the intervention than control group (21.16 ± 3.05 and 20.02 ± 3.40; p < 0.001. The increase in KAS in the intervention and control groups was significant (p < 0.001; KAS: 5.79 vs. 1.67 and suggested that children’s injury-related KAS improved in the intervention group. Moreover, the KAS between the groups differed for most subtypes of incidental injuries (based on International

Accidental hypothermia-an update

DEFF Research Database (Denmark)

Paal, Peter; Gordon, Les; Strapazzon, Giacomo

2016-01-01

BACKGROUND: This paper provides an up-to-date review of the management and outcome of accidental hypothermia patients with and without cardiac arrest. METHODS: The authors reviewed the relevant literature in their specialist field. Summaries were merged, discussed and approved to produce this nar......BACKGROUND: This paper provides an up-to-date review of the management and outcome of accidental hypothermia patients with and without cardiac arrest. METHODS: The authors reviewed the relevant literature in their specialist field. Summaries were merged, discussed and approved to produce...... this narrative review. RESULTS: The hospital use of minimally-invasive rewarming for non-arrested, otherwise healthy, patients with primary hypothermia and stable vital signs has the potential to substantially decrease morbidity and mortality for these patients. Extracorporeal life support (ECLS) has...... and post-resuscitation care. CONCLUSIONS: Based on new evidence, additional clinical experience and clearer management guidelines and documentation, the treatment of accidental hypothermia has been refined. ECLS has substantially improved survival and is the treatment of choice in the patient with unstable...

Medidas y estrategias para la prevención y control de los accidentes de tránsito: experiencia peruana por niveles de prevención Actions and strategies for the prevention and control of road traffic injuries: peruvian experience by levels of prevention

Directory of Open Access Journals (Sweden)

Hernán Málaga

2010-06-01

Full Text Available El presente artículo busca describir las principales medidas de prevención primaria y secundaria sobre accidentes de tránsito que vienen desarrollándose en Perú, considerando aspectos epidemiológicos propios de la experiencia peruana, como lo reportado en otros países. Se aborda lo a nivel de prevención primaria lo relacionado a la restricción horaria de expendio de bebidas alcohólicas, detección de conductores con alcoholemia positiva y el conductor elegido. En cuanto a prevención secundaria, se presenta los estudios de puntos negros y los barriles de contención de impacto, asimismo, una breve visión de los sistemas de atención pre hospitalaria en el caso de los traumatismos por accidentes de tránsito. Existe la necesidad de una mejor caracterización del problema, para establecer las políticas públicas saludables en lo concerniente a accidentes de tránsito, existe la necesidad de valoraciones basadas en evidencia científica y en estudios de evaluaciones económicas.This article aims to describe the main actions that are being developed in Peru for primary and secondary prevention of road traffic injuries, considering the epidemiological aspects that characterize the Peruvian experience, as reported in other countries. At the primary prevention level, it addresses issues related to the timing restriction of the sales of alcoholic beverages, detection of drivers with positive testing for alcohol in blood and the chosen driver. Regarding secondary prevention, the studies on black spots and the impact containment barrels are presented, also a brief overview of the pre-hospital care systems in the case of road traffic injuries. There is a need for better characterization of the problem, in order to establish healthy public policies regarding traffic accidents, there is a need for evidence-based reviews and studies of economic evaluations.

International Olympic Committee consensus statement: harassment and abuse (non-accidental violence) in sport.

Science.gov (United States)

Mountjoy, Margo; Brackenridge, Celia; Arrington, Malia; Blauwet, Cheri; Carska-Sheppard, Andrea; Fasting, Kari; Kirby, Sandra; Leahy, Trisha; Marks, Saul; Martin, Kathy; Starr, Katherine; Tiivas, Anne; Budgett, Richard

2016-09-01

Despite the well-recognised benefits of sport, there are also negative influences on athlete health, well-being and integrity caused by non-accidental violence through harassment and abuse. All athletes have a right to engage in 'safe sport', defined as an athletic environment that is respectful, equitable and free from all forms of non-accidental violence to athletes. Yet, these issues represent a blind spot for many sport organisations through fear of reputational damage, ignorance, silence or collusion. This consensus statement extends the 2007 IOC Consensus Statement on Sexual Harassment and Abuse in Sport, presenting additional evidence of several other types of harassment and abuse-psychological, physical and neglect. All ages and types of athletes are susceptible to these problems but science confirms that elite, disabled, child and lesbian/gay/bisexual/trans-sexual (LGBT) athletes are at highest risk, that psychological abuse is at the core of all other forms and that athletes can also be perpetrators. Harassment and abuse arise from prejudices expressed through power differences. Perpetrators use a range of interpersonal mechanisms including contact, non-contact/verbal, cyber-based, negligence, bullying and hazing. Attention is paid to the particular risks facing child athletes, athletes with a disability and LGBT athletes. Impacts on the individual athlete and the organisation are discussed. Sport stakeholders are encouraged to consider the wider social parameters of these issues, including cultures of secrecy and deference that too often facilitate abuse, rather than focusing simply on psychopathological causes. The promotion of safe sport is an urgent task and part of the broader international imperative for good governance in sport. A systematic multiagency approach to prevention is most effective, involving athletes, entourage members, sport managers, medical and therapeutic practitioners, educators and criminal justice agencies. Structural and

Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C

Directory of Open Access Journals (Sweden)

Roy Siddhartha

2008-11-01

Full Text Available Abstract Background Cigarette smoke-induced cellular and molecular mechanisms of lung injury are not clear. Cigarette smoke is a complex mixture containing long-lived radicals, including p-benzosemiquinone that causes oxidative damage. Earlier we had reported that oxidative protein damage is an initial event in smoke-induced lung injury. Considering that p-benzosemiquinone may be a causative factor of lung injury, we have isolated p-benzosemiquinone and compared its pathophysiological effects with cigarette smoke. Since vitamin C is a strong antioxidant, we have also determined the modulatory effect of vitamin C for preventing the pathophysiological events. Methods Vitamin C-restricted guinea pigs were exposed to cigarette smoke (5 cigarettes/day; 2 puffs/cigarette for 21 days with and without supplementation of 15 mg vitamin C/guinea pig/day. Oxidative damage, apoptosis and lung injury were assessed in vitro, ex vivo in A549 cells as well as in vivo in guinea pigs. Inflammation was measured by neutrophilia in BALF. p-Benzosemiquinone was isolated from freshly prepared aqueous extract of cigarette smoke and characterized by various physico-chemical methods, including mass, NMR and ESR spectroscopy. p-Benzosemiquinone-induced lung damage was examined by intratracheal instillation in guinea pigs. Lung damage was measured by increased air spaces, as evidenced by histology and morphometric analysis. Oxidative protein damage, MMPs, VEGF and VEGFR2 were measured by western blot analysis, and formation of Michael adducts using MALDI-TOF-MS. Apoptosis was evidenced by TUNEL assay, activation of caspase 3, degradation of PARP and increased Bax/Bcl-2 ratio using immunoblot analysis and confocal microscopy. Results Exposure of guinea pigs to cigarette smoke resulted in progressive protein damage, inflammation, apoptosis and lung injury up to 21 days of the experimental period. Administration of 15 mg of vitamin C/guinea pig/day prevented all these

Factors perceived as being related to accidental falls by persons with multiple sclerosis.

Science.gov (United States)

Nilsagård, Ylva; Denison, Eva; Gunnarsson, Lars-Gunnar; Boström, Katrin

2009-01-01

This study explores and describes factors that persons with multiple sclerosis (MS) perceive as being related to accidental falls. A qualitative content analysis with primarily deductive approach was conducted using the International Classification of Functioning, Disability and Health. Twelve persons with MS, and identified as fallers, were interviewed. Factors perceived to cause accidental falls that had not previously been targeted in MS populations in relation to falls were identified as divided attention, reduced muscular endurance, fatigue and heat sensitivity. Previously reported risk factors such as changed gait pattern, limited walking ability, impaired proprioception, vision and spasticity were supported. Activities involving walking, recreation and leisure, maintaining and changing body position, lifting or carrying, taking care of the home, washing the body, moving around, preparing meals and housekeeping were limited and considered to be risk activities. Supportive persons and assistive device reduced falls, and unsuitable physical environments and climate conditions induced falls. Several preventative strategies were described as partially compensating for the impairments, limitations and restrictions. Investigating accidental falls using the perspective of the patient gave important information about variables not earlier targeted in MS research.

Accidental childhood poisoning in Benin City: Still a problem ...

African Journals Online (AJOL)

Accidental poisoning (AP) is a leading cause of ill – health and deaths among. Nigerian children. Reports on AP are infrequent in Nigeria. This retrospective descriptive study examined the prevailing pattern of accidental childhood poisoning in Benin City. Accidental poisonings were identified in 226 (3.3%) of the cases ...

Tension Pneumothorax following an Accidental Kerosene Poisoning ...

African Journals Online (AJOL)

Tension pneumothorax is a rare complication following an accidental kerosene poisoning. In such situation, a bed-side needle thoracocentesis is performed because of its potential of becoming fatal; hence its clinical importance. A case of 15 month old boy with tension pneumothorax following accidental kerosene ...

Accidental Poisoning with Otapiapia: a Local Organophasphate ...

African Journals Online (AJOL)

Children are prone to accidental poisoning. We report this fatal organophosphate poisoning of a 3-year-old Nigerian boy following accidental ingestion of a homemade cocktail of kerosene and 'Otapiapia': a local rodenticide to highlight the dangers inherent in un-regulated production, home use and storage of this ...

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

Science.gov (United States)

Curia, G.; Lucchi, C.; Vinet, J.; Gualtieri, F.; Marinelli, C.; Torsello, A.; Costantino, L.; Biagini*,, G.

2014-01-01

Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly caused by a primary brain injury that occurred a long time before the appearance of neurological symptoms. This type of epilepsy is characterized by refractoriness to drug treatment, so to require surgical resection of mesial temporal regions involved in seizure onset. Even this last therapeutic approach may fail in giving relief to patients. Although prevention of hippocampal damage and epileptogenesis after a primary event could be a key innovative approach to TLE, the lack of clear data on the pathophysiological mechanisms leading to TLE does not allow any rational therapy. Here we address the current knowledge on mechanisms supposed to be involved in epileptogenesis, as well as on the possible innovative treatments that may lead to a preventive approach. Besides loss of principal neurons and of specific interneurons, network rearrangement caused by axonal sprouting and neurogenesis are well known phenomena that are integrated by changes in receptor and channel functioning and modifications in other cellular components. In particular, a growing body of evidence from the study of animal models suggests that disruption of vascular and astrocytic components of the blood-brain barrier takes place in injured brain regions such as the hippocampus and piriform cortex. These events may be counteracted by drugs able to prevent damage to the vascular component, as in the case of the growth hormone secretagogue ghrelin and its analogues. A thoroughly investigation on these new pharmacological tools may lead to design effective preventive therapies. PMID:24251566

Characterisation of childhood and adolescence accidental fatalities ...

African Journals Online (AJOL)

Background: Accidental death in childhood and adolescence is posing a public health problem in Nigeria, as most of these deaths were not caused by the victims. There is need to research into the pattern and circumstances surrounding the death. Aim: To characterise and study accidental deaths in childhood and ...

Accidental ingestion of BiTine ring and a note on inefficient ring separation forceps

Directory of Open Access Journals (Sweden)

Baghele ON

2011-05-01

Full Text Available Om Nemichand Baghele1, Mangala Om Baghele21Department of Periodontology, SMBT Dental College and Hospital, Sangamner, Ahmednagar, Maharashtra, India; 2Private General Dental Practice, Mumbai, IndiaBackground: Accidental ingestion of medium-to-large instruments is relatively uncommon during dental treatment but can be potentially dangerous. A case of BiTine ring ingestion is presented with a note on inefficient ring separation forceps.Case description: A 28-year-old male patient accidentally ingested the BiTine ring (2 cm diameter, 0.5 cm outward projections while it was being applied to a distoproximal cavity in tooth # 19. The ring placement forceps were excessively flexible; bending of the beaks towards the ring combined with a poor no-slippage mechanism led to sudden disengagement of the ring and accelerated movement towards the pharynx. We followed the patient with bulk forming agents and radiographs. Fortunately the ring passed out without any complications.Clinical implications: Checking equipment and methods is as important as taking precautions against any preventable medical emergency. It is the responsibility of the clinician to check, verify and then use any instrument/equipment.Keywords: foreign bodies/radiography, foreign bodies/complications, equipment failure, dental instrument, accidental ingestion

About Assessment Criteria of Driver's Accidental Abilities

Science.gov (United States)

Lobanova, Yuliya I.; Glushko, Kirill V.

2016-01-01

The article points at the importance of studying the human factor as a cause of accidents of drivers, especially in loosely structured traffic situations. The description of the experiment on the measurement of driver's accidental abilities is given. Under accidental ability is meant the capability to ensure the security of driving as a behavior…

Accidentes en los niños, un problema de salud actual: Revisión bibliográfica

Directory of Open Access Journals (Sweden)

Everardo Valdés Pacheco

1996-06-01

Full Text Available Se realiza una revisión bibliográfica sobre el tema Accidente, especialmente en los niños, y se resalta la importancia de la prevención de éstos, pues constituyen la primera causa de muerte en nuestro país en los menores entre 1 y 14 años de edad. Se brinda información sobre los tipos y causas principales de accidentes en estas edades, así como las recomendaciones para la labor preventiva del equipo de salud en la atención primaria.A bibliographic review on the topic of accidents, specially in children, is carried out, and it is stressed the importance of prevention, since they are the first cause of death among children aged 1-14 years. Information is provided on the types and main causes of accidents at these ages. Recommendations are also given for the preventive work of the health team in primary care.

Comparison between cytogenetic damage induced in human lymphocytes by environmental chemicals or radiation

Energy Technology Data Exchange (ETDEWEB)

Cebulska-Wasilewska, A. [Institute of Nuclear Physics, Cracow (Poland)

1997-12-31

Author compared cytogenetic effects of chemicals (benzene and the member at benzene related compounds) and ionizing radiation on the human lymphocytes. Levels of various types of cytogenetic damage observed among people from petroleum plants workers groups are similar to the levels of damages detected in the blood of people suspected of the accidental exposure to a radiation source

Comparison between cytogenetic damage induced in human lymphocytes by environmental chemicals or radiation

International Nuclear Information System (INIS)

Cebulska-Wasilewska, A.

1997-01-01

Author compared cytogenetic effects of chemicals (benzene and the member at benzene related compounds) and ionizing radiation on the human lymphocytes. Levels of various types of cytogenetic damage observed among people from petroleum plants workers groups are similar to the levels of damages detected in the blood of people suspected of the accidental exposure to a radiation source

Bee products prevent agrichemical-induced oxidative damage in fish.

Directory of Open Access Journals (Sweden)

Daiane Ferreira

Full Text Available In southern South America and other parts of the world, aquaculture is an activity that complements agriculture. Small amounts of agrichemicals can reach aquaculture ponds, which results in numerous problems caused by oxidative stress in non-target organisms. Substances that can prevent or reverse agrichemical-induced oxidative damage may be used to combat these effects. This study includes four experiments. In each experiment, 96 mixed-sex, 6-month-old Rhamdia quelen (118±15 g were distributed into eight experimental groups: a control group that was not exposed to contaminated water, three groups that were exposed to various concentrations of bee products, three groups that were exposed to various concentrations of bee products plus tebuconazole (TEB; Folicur 200 CE™ and a group that was exposed to 0.88 mg L(-1 of TEB alone (corresponding to 16.6% of the 96-h LC50. We show that waterborne bee products, including royal jelly (RJ, honey (H, bee pollen (BP and propolis (P, reversed the oxidative damage caused by exposure to TEB. These effects were likely caused by the high polyphenol contents of these bee-derived compounds. The most likely mechanism of action for the protective effects of bee products against tissue oxidation and the resultant damage is that the enzymatic activities of superoxide dismutase (SOD, catalase (CAT and glutathione-S-transferase (GST are increased.

Bee products prevent agrichemical-induced oxidative damage in fish.

Science.gov (United States)

Ferreira, Daiane; Rocha, Helio Carlos; Kreutz, Luiz Carlos; Loro, Vania Lucia; Marqueze, Alessandra; Koakoski, Gessi; da Rosa, João Gabriel Santos; Gusso, Darlan; Oliveira, Thiago Acosta; de Abreu, Murilo Sander; Barcellos, Leonardo José Gil

2013-01-01

In southern South America and other parts of the world, aquaculture is an activity that complements agriculture. Small amounts of agrichemicals can reach aquaculture ponds, which results in numerous problems caused by oxidative stress in non-target organisms. Substances that can prevent or reverse agrichemical-induced oxidative damage may be used to combat these effects. This study includes four experiments. In each experiment, 96 mixed-sex, 6-month-old Rhamdia quelen (118±15 g) were distributed into eight experimental groups: a control group that was not exposed to contaminated water, three groups that were exposed to various concentrations of bee products, three groups that were exposed to various concentrations of bee products plus tebuconazole (TEB; Folicur 200 CE™) and a group that was exposed to 0.88 mg L(-1) of TEB alone (corresponding to 16.6% of the 96-h LC50). We show that waterborne bee products, including royal jelly (RJ), honey (H), bee pollen (BP) and propolis (P), reversed the oxidative damage caused by exposure to TEB. These effects were likely caused by the high polyphenol contents of these bee-derived compounds. The most likely mechanism of action for the protective effects of bee products against tissue oxidation and the resultant damage is that the enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) are increased.

The Accidental Transgressor: Morally Relevant Theory of Mind

Science.gov (United States)

Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah

2014-01-01

To test young children’s false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N = 162) at 3.5, 5.5, and 7.5 years of age were administered 3 tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an “accidental transgressor” task, which measured a morally relevant false belief theory of mind (MoToM). Children who did not pass false belief ToM were more likely to attribute negative intentions to an accidental transgressor than children who passed false belief ToM, and to use moral reasons when blaming the accidental transgressor. In Experiment 2, children (N = 46) who did not pass false belief ToM viewed it as more acceptable to punish the accidental transgressor than did participants who passed false belief ToM. Findings are discussed in light of research on the emergence of moral judgment and theory of mind. PMID:21377148

[Urinary incontinence and other pelvic floor damages: ethilogy and prevention strategies].

Science.gov (United States)

Amóstegui Azcúe, J M; Ferri Morales, A; Lillo De La Quintana, C; Serra Llosa, M L

2004-01-01

Urinary incontinence, as well as additional pelvic floor damage, such as third and fourth degree muscular lacerations, as well as fecal incontinence, genital prolapse or dyspareunia, result from obstetric trauma, and are generally linked to the first delivery. The purpose of this study is to analyze, from a physiotherapeutic point of view, and therefore from the perspective of muscular physiology and biomechanics, why this damage occurs, while studying the birth process and the way it is currently performed in most hospitals in our country. Analysis of the birth process and, in short, of the different types of positions used for the first and second stage of labor, as well as of the care provided for women in the puerperium, leads us to propose a global prevention strategy to be carried out in three stages: --Ante-natal prevention: specific preparation of the pelvic floor and abdominal musculature during pregnancy, using massage techniques and manual stretching of the perineum. In addition, the pregnant woman learns these positions and methods of pushing, which makes the first and second stage of labour easier. An osteopathic treatment of the pelvis joints is performed in order to facilitate their mobility or to liberate blockades, if they exist. --Prevention during labour: During this stage, physiology is respected and manual, position-based and breathing techniques are implemented in order to enhance the protection of the baby and of the pelvic floor. --Postpartum prevention: The action is focused on the pelvic floor, through diaphragmatic and abdominal exercises or postures and, if necessary, osteopathic treatment in the early puerperium, in order to facilitate the correct involution of all soft tissues and the pelvic joints involved in labor. Early specific physiotherapeutic treatment will be proposed for women with functional pathology six weeks after delivery.

Concurrent Transient Activation of Wnt/{beta}-Catenin Pathway Prevents Radiation Damage to Salivary Glands

Energy Technology Data Exchange (ETDEWEB)

Hai Bo; Yang Zhenhua; Shangguan Lei; Zhao Yanqiu [Institute for Regenerative Medicine, Scott and White Hospital, Molecular and Cellular Medicine Department, Texas A and M Health Science Center, Temple, Texas (United States); Boyer, Arthur [Department of Radiology, Scott and White Hospital, Temple, Texas (United States); Liu, Fei, E-mail: fliu@medicine.tamhsc.edu [Institute for Regenerative Medicine, Scott and White Hospital, Molecular and Cellular Medicine Department, Texas A and M Health Science Center, Temple, Texas (United States)

2012-05-01

Purpose: Many head and neck cancer survivors treated with radiotherapy suffer from permanent impairment of their salivary gland function, for which few effective prevention or treatment options are available. This study explored the potential of transient activation of Wnt/{beta}-catenin signaling in preventing radiation damage to salivary glands in a preclinical model. Methods and Materials: Wnt reporter transgenic mice were exposed to 15 Gy single-dose radiation in the head and neck area to evaluate the effects of radiation on Wnt activity in salivary glands. Transient Wnt1 overexpression in basal epithelia was induced in inducible Wnt1 transgenic mice before together with, after, or without local radiation, and then saliva flow rate, histology, apoptosis, proliferation, stem cell activity, and mRNA expression were evaluated. Results: Radiation damage did not significantly affect activity of Wnt/{beta}-catenin pathway as physical damage did. Transient expression of Wnt1 in basal epithelia significantly activated the Wnt/{beta}-catenin pathway in submandibular glands of male mice but not in those of females. Concurrent transient activation of the Wnt pathway prevented chronic salivary gland dysfunction following radiation by suppressing apoptosis and preserving functional salivary stem/progenitor cells. In contrast, Wnt activation 3 days before or after irradiation did not show significant beneficial effects, mainly due to failure to inhibit acute apoptosis after radiation. Excessive Wnt activation before radiation failed to inhibit apoptosis, likely due to extensive induction of mitosis and up-regulation of proapoptosis gene PUMA while that after radiation might miss the critical treatment window. Conclusion: These results suggest that concurrent transient activation of the Wnt/{beta}-catenin pathway could prevent radiation-induced salivary gland dysfunction.

Concurrent Transient Activation of Wnt/β-Catenin Pathway Prevents Radiation Damage to Salivary Glands

International Nuclear Information System (INIS)

Hai Bo; Yang Zhenhua; Shangguan Lei; Zhao Yanqiu; Boyer, Arthur; Liu, Fei

2012-01-01

Purpose: Many head and neck cancer survivors treated with radiotherapy suffer from permanent impairment of their salivary gland function, for which few effective prevention or treatment options are available. This study explored the potential of transient activation of Wnt/β-catenin signaling in preventing radiation damage to salivary glands in a preclinical model. Methods and Materials: Wnt reporter transgenic mice were exposed to 15 Gy single-dose radiation in the head and neck area to evaluate the effects of radiation on Wnt activity in salivary glands. Transient Wnt1 overexpression in basal epithelia was induced in inducible Wnt1 transgenic mice before together with, after, or without local radiation, and then saliva flow rate, histology, apoptosis, proliferation, stem cell activity, and mRNA expression were evaluated. Results: Radiation damage did not significantly affect activity of Wnt/β-catenin pathway as physical damage did. Transient expression of Wnt1 in basal epithelia significantly activated the Wnt/β-catenin pathway in submandibular glands of male mice but not in those of females. Concurrent transient activation of the Wnt pathway prevented chronic salivary gland dysfunction following radiation by suppressing apoptosis and preserving functional salivary stem/progenitor cells. In contrast, Wnt activation 3 days before or after irradiation did not show significant beneficial effects, mainly due to failure to inhibit acute apoptosis after radiation. Excessive Wnt activation before radiation failed to inhibit apoptosis, likely due to extensive induction of mitosis and up-regulation of proapoptosis gene PUMA while that after radiation might miss the critical treatment window. Conclusion: These results suggest that concurrent transient activation of the Wnt/β-catenin pathway could prevent radiation-induced salivary gland dysfunction.

South Dakota accidental childhood deaths, 2000-2007: what can we do?

Science.gov (United States)

Svien, Lana R; Senne, Svien A; Rasmussen, Carl

2010-05-01

Unintentional injuries are the leading cause of death in children around the world and are an under-recognized public health problem in the United States. The purpose of this study was to highlight the nature of the problem in South Dakota and outline interventions that have been successful in reducing childhood injuries in other states. This quantitative retrospective study examined mortality files in South Dakota for children birth to 19 years of age who died between January 1, 2000 to December 28, 2007. Although the number of deaths declined considerably from 2006 to 2007, South Dakota had the second-highest rate in the nation of childhood unintentional injury deaths from all causes between 2000-2005. The majority of deaths occurred in males and were associated with transportation-related deaths. Suffocation was the leading cause of death for newborns to age 1 year. Childhood accidental death in South Dakota is clearly a critical public health problem. Intervention efforts to reduce deaths from unintentional injuries amongst children should be targeted as the leading causes of accidental death for specific age groups and American Indian youth. Physicians, health educators and policymakers must play a role in prevention targeting the high-risk groups in addition to advocating for policy changes to protect childhood safety. More stringent child restraint laws, graduated driving laws, smoking cessation programs for parents, creation of safer sleep environments and further investigation of why a high proportion of American Indian children die accidentally in South Dakota are all warranted.

Intelligent system for accident identification in NPP; Sistema inteligente para la identificacion de accidentes en centrales nucleares

Energy Technology Data Exchange (ETDEWEB)

Hernandez, J L [Centro Nacional de Seguridad Nuclear, La Habana (Cuba)

1999-12-31

Accidental situations in NPP are great concern for operators, the facility, regulatory bodies and the environmental. This work proposes a design of intelligent system aimed to assist the operator in the process of decision making initiator events with higher relative contribution to the reactor core damage occur. The intelligent System uses the results of the pre-operational Probabilistic safety Assessment and the Thermal hydraulic Safety Analysis of the NPP Juragua as source for building its knowledge base. The nucleus of the system is presented as a design of an intelligent hybrid from the combination of the artificial intelligence techniques fuzzy logic and artificial neural networks. The system works with variables from the process of the first circuit, second circuit and the containment and it is presented as a model for the integration of safety analyses in the process of decision making by the operator when tackling with accidental situations

Development of hybrid organic-inorganic optical coatings to prevent laser damage

International Nuclear Information System (INIS)

Compoint, Francois

2015-01-01

The optical devices (lents, mirrors, portholes...) that are set on the chains of the Laser Megajoule (LMJ) may be damaged by the high energy laser beam especially around the UV wavelength of 351 nm. The damages are micronic craters on the rear of the optics that grows exponentially after each laser shots. The study aims at developing some optical thin coatings on the rear of the optical substrates to prevent the growth of the damage by amortizing the laser shock wave, self-healing the craters that has appeared, or repairing the laser hole after the damage occurs. The thin coatings have been prepared by a sol-gel method by using silica precursor and a polydimethylsiloxane (PDMS) elastomer. The two species reacted together to get a hybrid organic-inorganic Ormosil (organically modified silica) material, by creating a silica network linked to the PDMS species with covalent and hydrogen bounds. The thin layers are obtained from the sol-gel solution by using a dip and spin coating method. The coatings have an excellent optical transmission around the UV (351 nm) wavelength. They also have some self-healing properties by using mechanical (viscoelastic) mechanism and chemical reversible hydrogen bounds action in the materials. The silica-PDMS coatings prove to be resistant to the laser beam at 351 nm, despite some optimizations that still need to be done to reach the sought laser damage threshold. (author) [fr

Biologic markers of air-pollution stress and damage in forests

National Research Council Canada - National Science Library

1989-01-01

...-Pollution Damage in Trees Board on Environmental Studies and Toxicology Commission on Life Sciences National Research Council NATIONAL ACADEMY PRESS Washington, D.C. 1989 i Copyrighttrue Please breaks inserted. are Page files. accidentally typesetting been have may original from the errors not typographic original retained, and from th...

Assessment of preventive measures for accidental blood exposure in operating theaters: a survey of 20 hospitals in Northern France.

Science.gov (United States)

Tarantola, Arnaud; Golliot, Franck; L'Heriteau, François; Lebascle, Karin; Ha, Catherine; Farret, Danièle; Bignon, Sylvie; Smaïl, Amar; Doutrellot-Philippon, Catherine; Astagneau, Pascal; Bouvet, Elisabeth

2006-08-01

Accidental exposures to blood of body fluids (ABE) expose health care workers (HCW) to the risk of occupational infection. Our aim was to assess the prevention equipment available in the operating theater (OT) with reference to guidelines or recommendations and its use by the staff in that OT on that day and past history of ABE. Correspondents of the Centre de Coordination de la Lutte contre les Infections Nosocomiales (CCLIN) Paris-Nord ABE Surveillance Taskforce carried out an observational multicenter survey in 20 volunteer French hospitals. In total, 260 operating staff (including 151 surgeons) were investigated. Forty-nine of the 260 (18.8%) staff said they double-gloved for all patients and procedures, changing gloves hourly. Blunt-tipped suture needles were available in 49.1% of OT; 42 of 76 (55.3%) of the surgeons in these OT said they never used them. Overall, 60% and 64% of surgeons had never self-tested for HIV and hepatitis C virus (HCV), respectively. Fifty-five surgeons said they had sustained a total of 96 needlestick injuries during the month preceding the survey. Ten of these surgeons had notified of 1 needlestick injury each to the occupational health department of their hospital (notification rate, 10.4%). The occurrence of needlestick injury remained high in operating personnel in France in 2000. Although hospitals may improve access to protective devices, operating staff mindful of safety in the OT should increase their use of available devices, their knowledge of their own serostatus, and their ABE notification rate to guide well-targeted prevention efforts.

Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions

International Nuclear Information System (INIS)

Bueno, Giselle Oliveira Vieira

2007-01-01

In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that these errors do not

Accidental and retrospective dosimetry using TL method

International Nuclear Information System (INIS)

Mesterházy, D.; Osvay, M.; Kovács, A.; Kelemen, A.

2012-01-01

Retrospective dosimetry is one of the most important tools of accidental dosimetry for dose estimation when dose measurement was not planned. In the affected area many objects can be applied as natural dosimeters. The paper discusses our recent investigations on various electronic components and common salt (NaCl) having useful thermoluminescence (TL) properties. Among materials investigated the electronic components of cell phones seem promising for retrospective dosimetry purposes, having high TL responses, proper glow curve peaks and the intensity of TL peaks vs. gamma dose received provided nearly linear response in the dose range of 10 mGy–1.5 Gy. - Highlights: ► Electronic components and common salt were investigated for accidental and retrospective dosimetry. ► SMD resistors seem promising for retrospective dosimetry purposes. ► Table salt can be used effectively for accidental dosimetry purposes, as well.

Normal neurologic and developmental outcome after an accidental intravenous infusion of expressed breast milk in a neonate.

LENUS (Irish Health Repository)

Ryan, C Anthony

2012-02-03

Here we describe a premature male infant who was accidentally given 10 mL of expressed breast milk intravenously over a 3.5-hour period. Having survived this event with supportive care, this boy was attending regular school with no obvious neurologic or learning difficulties at 6 years of age. In 1998, after a query on an e-mail discussion group for health care providers in neonatology (NICU-net), we were informed of 8 similar events that proved fatal in 3 infants. A root-cause analysis revealed that accidental intravenous administration of breast milk or formula can be avoided by the use of color-coded enteral-administration sets with Luer connections that are not compatible with intravenous cannulas. The addition of methylene blue to feeds, or bolus enteral feeds (instead of continuous gastric feedings), may also help prevent such errors. These cases show the value of gathering information about rare but important events through a neonatal network. In addition, they confirm that prevention of medical error should focus on faulty systems rather than faulty people.

Accidental Continuous Releases from Coal Processing in Semi-Confined Environment

Directory of Open Access Journals (Sweden)

Bruno Fabiano

2013-09-01

Full Text Available Notwithstanding the enforcement of ATEX EU Directives (94/9/EC of 23 March 1994 and safety management system application, explosions in the coal sector still claim lives and cause huge economic losses. Even a consolidated activity like coke dry distillation allows the opportunity of preventing explosion risk connected to fugitive emissions of coke oven gas. Considering accidental releases under semi-confined conditions, a simplified mathematical approach to the maximum allowed gaseous build-up is developed on the basis of the intrinsic hazards of the released compound. The results will help identifying and assessing low rate release consequences therefore to set-up appropriate prevention and control measures. The developed methodology was tested at the real-scale and validated by numerical computational fluid dynamics (CFD simulations showing the effectiveness of the methodology to evaluate and mitigate the risk connected to confined hazardous releases.

Evaluación económica del daño moral en el ámbito de los accidentes de trabajo: un método basado en indicadores estadísticos normalizados

Directory of Open Access Journals (Sweden)

José Luis Navarro Espigares

2008-06-01

Full Text Available Dos recientes pronunciamientos de la Sala 4 ª de lo Social del Tribunal Supremo han puesto fin a la doctrina jurisprudencial por la que, para evitar el "enriquecimiento injusto" del trabajador accidentado, se exoneraba al empresario del deber de reparar los perjuicios causados en un accidente de trabajo o enfermedad profesional, por el incumplimientos de sus obligaciones en materia de seguridad. Este cambio jurisprudencial obliga a abordar la cuantificación económica de los distintos componentes indemnizatorios. En este trabajo ofrecemos un novedoso método para la evaluación económica directa del daño moral basado los años de vida ajustados por calidad perdidos por los trabajadores que sufren un accidente de trabajo. El método propuesto se ofrece como una alternativa ventajosa frente a la utilización del baremo de tráfico.Two recent Social Supreme Court rulings have put an end to the jurisprudential doctrine that prevented the "unfair enrichment" of an injured worker. This doctrine exempted the employer from the obligation of repairing the damage caused by work accidents or occupational diseases, stemming from breaches of the employer’s security obligations. The jurisprudential change requires addressing the economic quantification of the various components of workers’ compensation. Our study offers a novel method for assessing the economic value of moral damage based on Quality Adjusted Life Years lost by workers who suffer a work accident. The proposed method is presented as an alternative that is more appropriate than the use of the traffic scale.

Factores de riesgo relacionados con los accidentes domésticos

Directory of Open Access Journals (Sweden)

Nereida Pacios Alfonso

1998-10-01

Full Text Available Se realiza observación de los factores de riesgo en 176 hogares durante 12 meses. Se clasifican los apartamentos en 3 grupos según el número de factores detectados. Se visitan trimestralmente y se observan las características de los accidentes domésticos ocurridos. En el 30% de los hogares se concentra el 63% de los accidentes, la morbilidad mayor se concentra en los hogares en que hay mayor número de factores de riesgo, lo que nos hace pensar que el trabajo educativo debe ser planificado y diferenciado, especialmente dirigido a modificar conductas en los hogares de alto riesgo para hacer más efectiva la prevención del fenómenoRisk factors are observed at 176 homes during 12 months. Apartments are classified into 3 groups according to the number of factors. Homes are quarterly visited and the characteristics of the accidents occurred are analyzed. 63 % of the accidents are detected in 30 % of the houses. The highest morbidity is concentrated on those houses having more risk factors, which makes us think that the educative work must be planned and differentiated, specially directed to modify conducts at high risk houses in order to make the prevention of the phenomenon more effective

The effects of acute irradiation on a forest biogeocenosis: Experimental data, model and practical applications for accidental cases

International Nuclear Information System (INIS)

Alexakhin, R.M.; Karaban, R.T.; Prister, B.S.

1994-01-01

The effects of acute irradiations of a mixed pine and birch forest in spring and autumn with a high power point-type gamma radiation source (1180 TBq 137 Cs) have been described. Radiation dose relationships for numerous response reactions of woody and herbaceous plants (growth and development of organs of woody plants, cytogenetical, physiological and biochemical changes in trees, reproductive potential of plants, damage and dying off of the forest as a biogeocenosis on the whole) have been calculated. Post-radiation recovery of the forest was investigated. Changes involving the secondary reactions related to radiation damage and death of the trees are presented. A model for radiation damage of forests has been designed. Examples are given on the usage of this model in the description of radiation effects in forests in the event of accidental releases of radionuclides into environment

Últimos perfiles del accidente de trabajo en misión

OpenAIRE

Poquet Catalá, Raquel

2017-01-01

En este trabajo se analiza desde un punto de vista de la doctrina judicial y jurisprudencial la construcción doctrinal del accidente de trabajo en misión como derivación del accidente de trabajo in itinere y como configuración propia del accidente de trabajo en sí. Así, se procede a la delimitación respecto del accidente in itinere, se realiza un análisis de los requisitos configuradores del mismo, tanto genéricos como específicos, así como la aplicabilidad de la presunción iuris tantum de la...

Accidental strangulation in children by the automatic closing of a car window.

Science.gov (United States)

Serena, Kailene; Piva, Jefferson Pedro; Andreolio, Cinara; Carvalho, Paulo Roberto Antonacci; Rocha, Tais Sica da

2018-03-01

Among the main causes of death in our country are car accidents, drowning and accidental burns. Strangulation is a potentially fatal injury and an important cause of homicide and suicide among adults and adolescents. In children, its occurrence is usually accidental. However, in recent years, several cases of accidental strangulation in children around the world have been reported. A 2-year-old male patient was strangled in a car window. The patient was admitted to the pediatric intensive care unit with a Glasgow Coma Scale score of 8 and presented with progressive worsening of respiratory dysfunction and torpor. The patient also presented acute respiratory distress syndrome, acute pulmonary edema and shock. He was managed with protective mechanical ventilation, vasoactive drugs and antibiotic therapy. He was discharged from the intensive care unit without neurological or pulmonary sequelae. After 12 days of hospitalization, he was discharged from the hospital, and his state was very good. The incidence of automobile window strangulation is rare but of high morbidity and mortality due to the resulting choking mechanism. Fortunately, newer cars have devices that stop the automatic closing of the windows if resistance is encountered. However, considering the severity of complications strangulated patients experience, the intensive neuro-ventilatory and hemodynamic management of the pathologies involved is important to reduce morbidity and mortality, as is the need to implement new campaigns for the education of parents and caregivers of children, aiming to avoid easily preventable accidents and to optimize safety mechanisms in cars with electric windows.

Accidental strangulation in children by the automatic closing of a car window

Science.gov (United States)

Serena, Kailene; Piva, Jefferson Pedro; Andreolio, Cinara; Carvalho, Paulo Roberto Antonacci; da Rocha, Tais Sica

2018-01-01

Among the main causes of death in our country are car accidents, drowning and accidental burns. Strangulation is a potentially fatal injury and an important cause of homicide and suicide among adults and adolescents. In children, its occurrence is usually accidental. However, in recent years, several cases of accidental strangulation in children around the world have been reported. A 2-year-old male patient was strangled in a car window. The patient was admitted to the pediatric intensive care unit with a Glasgow Coma Scale score of 8 and presented with progressive worsening of respiratory dysfunction and torpor. The patient also presented acute respiratory distress syndrome, acute pulmonary edema and shock. He was managed with protective mechanical ventilation, vasoactive drugs and antibiotic therapy. He was discharged from the intensive care unit without neurological or pulmonary sequelae. After 12 days of hospitalization, he was discharged from the hospital, and his state was very good. The incidence of automobile window strangulation is rare but of high morbidity and mortality due to the resulting choking mechanism. Fortunately, newer cars have devices that stop the automatic closing of the windows if resistance is encountered. However, considering the severity of complications strangulated patients experience, the intensive neuro-ventilatory and hemodynamic management of the pathologies involved is important to reduce morbidity and mortality, as is the need to implement new campaigns for the education of parents and caregivers of children, aiming to avoid easily preventable accidents and to optimize safety mechanisms in cars with electric windows.

Radiation exposure and chromosome damage

International Nuclear Information System (INIS)

Lloyd, D.

1979-01-01

Chromosome damage is discussed as a means of biologically measuring radiation exposure to the body. Human lymphocytes are commonly used for this test since the extent of chromosome damage induced is related to the exposure dose. Several hundred lymphocytes are analysed in metaphase for chromosome damage, particularly dicentrics. The dose estimate is made by comparing the observed dicentric yield against calibration curves, previously produced by in vitro irradiation of blood samples to known doses of different types of radiation. This test is useful when there is doubt that the film badge has recorded a reasonable whole body dose and also when there is an absence of any physical data. A case of deliberate exposure is described where the chromosome damage test estimated an exposure of 152 rads. The life span of cell aberrations is also considered. Regular checks on radiotherapy patients and some accidental overdose cases have shown little reduction in the aberration levels over the first six weeks after which the damage disappears slowly with a half-life of about three years. In conclusion, chromosome studies have been shown to be of value in resolving practical problems in radiological protection. (U.K.)

Accidental injury of the inferior alveolar nerve due to the extrusion of calcium hydroxide in endodontic treatment: a case report

Directory of Open Access Journals (Sweden)

Yooseok Shin

2016-02-01

Full Text Available During clinical endodontic treatment, we often find radiopaque filling material beyond the root apex. Accidental extrusion of calcium hydroxide could cause the injury of inferior alveolar nerve, such as paresthesia or continuous inflammatory response. This case report presents the extrusion of calcium hydroxide and treatment procedures including surgical intervention. A 48 yr old female patient experienced Calcipex II extrusion in to the inferior alveolar canal on left mandibular area during endodontic treatment. After completion of endodontic treatment on left mandibular first molar, surgical intervention was planned under general anesthesia. After cortical bone osteotomy and debridement, neuroma resection and neurorrhaphy was performed, and prognosis was observed. But no improvement in sensory nerve was seen following surgical intervention after 20 mon. A clinician should be aware of extrusion of intracanal medicaments and the possibility of damage on inferior alveolar canal. Injectable type of calcium hydroxide should be applied with care for preventing nerve injury. The alternative delivery method such as lentulo spiral was suggested on the posterior mandibular molar.

Analysis of accidental UF6 releases

International Nuclear Information System (INIS)

Fan Yumao; Tan Rui; Gao Qifa

2012-01-01

As interim substance in the nuclear fuel enrichment process, Uranium Hexafluoride (UF 6 ) is widely applied in nuclear processing, enrichment and fuel fabrication plants. Because of its vivid chemical characteristics and special radiological hazard and chemical toxicity, great attention must be paid to accident of UF 6 leakage. The chemical reactions involved in UF 6 release processes were introduced, therewith potential release styles, pathways and characteristics of diffusion were analyzed. The results indicated that the accidental release process of UF 6 is not a simple passive diffusion. So, specific atmospheric diffusion model related to UF 6 releases need be used in order to analyze and evaluate accurately the accidental consequences. (authors)

Which is the most preventive measure against tail damage in finisher pigs: tail docking, straw provision or lowered stocking density?

DEFF Research Database (Denmark)

Larsen, Mona Lilian Vestbjerg; Andersen, Heidi Mai-Lis; Pedersen, Lene Juul

2018-01-01

One challenge of intensive pig production is tail damage caused by tail biting, and farmers often decrease the prevalence of tail damage through tail docking. However, tail docking is not an optimal preventive measure against tail damage and thus, it would be preferable to replace it. The aim of ...

The 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

Science.gov (United States)

Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H MacG; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

2014-10-01

not risk factors for accidental awareness: ASA physical status; race; and use or omission of nitrous oxide. We recommend that an anaesthetic checklist, to be an integral part of the World Health Organization Safer Surgery checklist, is introduced as an aid to preventing accidental awareness. This paper is a shortened version describing the main findings from 5th National Audit Project - the full report can be found at http://www.nationalauditprojects.org.uk/NAP5_home#pt. © 2014 by the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland. This article is being published jointly in Anaesthesia and the British Journal of Anaesthesia.

5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

Science.gov (United States)

Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

2014-10-01

of nitrous oxide. We recommend that an anaesthetic checklist, to be an integral part of the World Health Organization Safer Surgery checklist, is introduced as an aid to preventing accidental awareness. This paper is a shortened version describing the main findings from NAP5--the full report can be found at http://www.nationalauditprojects.org.uk/NAP5_home. © The Author 2014. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Allegheny County Fatal Accidental Overdoses

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Fatal accidental overdose incidents in Allegheny County, denoting age, gender, race, drugs present, zip code of incident and zip code of residence. Zip code of...

An application of cost-effectiveness analysis to restrict the damage caused by an accidental release of radioactive material to the environment

International Nuclear Information System (INIS)

Frittelli, L.; Tamburrano, A.

1980-01-01

When an accidental release of radioactive material occurs health effects in the exposed population can be mitigated by remedial actions applied to individuals or their environment. A cost-effectiveness analysis is performed by comparing the cost of remedial action with the monetary value of the collective dose avoided. (H.K.)

Structural damages prevention of the ITER vacuum vessel and ports by elasto-plastic analysis with regards to RCC-MR

Energy Technology Data Exchange (ETDEWEB)

Martinez, Jean-Marc, E-mail: jean-marc.martinez@iter.org [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Jun, Chang Hoon; Portafaix, Christophe; Alekseev, Alexander; Sborchia, Carlo; Choi, Chang-Ho [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Albin, Vincent [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Borrelly, Stephane [Sogeti High Tech, RE2, 180 rue René Descartes, Le Millenium – Bat C, 13857 Aix en Provence (France); Cambazar, Magali [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France); Gaucher, Thomas [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Sfarni, Samir; Tailhardat, Olivier [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France)

2015-10-15

Highlights: • ITER vacuum vessel (VV) is a part of the first barrier to confine the plasma. • ITER VV as NPE necessitates a third party organization authorized by the French nuclear regulator to assure design, fabrication, and conformance testing and quality assurance, i.e. ANB. • Several types of damages have to be prevented in order to guarantee the structural integrity with regards to RCC-MR. • It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. • Several structural analyses were performed with many different global and local models of the whole ITER VV. - Abstract: Several types of damages have to be prevented in order to guarantee the structural integrity of a structure with regards to RCC-MR; the P-type damages which can result from the application to a structure of a steadily and regularly increasing loading or a constant loading and the S-type damages during operational loading conditions which can only result from repeated application of loadings associated to the progressive deformations and fatigue. Following RCC-MR, the S-type damages prevention has to be started only when the structural integrity is guaranteed against P-type damages. The verification of the last one on the ITER vacuum vessel and ports has been performed by limit analysis with elasto-(perfectly)plastic material behavior. It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. Some elasto-plastic analyses have been performed considering several cyclic loadings to evaluate also more realistic structural margins of the against S-type damages.

Post accidental small breaks analysis

International Nuclear Information System (INIS)

Depond, G.; Gandrille, J.

1980-04-01

EDF ordered to FRAMATOME by 1977 to complete post accidental long term studies on 'First Contrat-Programme' reactors, in order to demonstrate the safety criteria long term compliance, to get information on NSSS behaviour and to improve the post accidental procedures. Convenient analytical models were needed and EDF and FRAMATOME respectively developped the AXEL and FRARELAP codes. The main results of these studies is that for the smallest breaks, it is possible to manually undertake cooling and pressure reducing actions by dumping the steam generators secondary side in order to meet the RHR operating specifications and perform long term cooling through this system. A specific small breaks procedure was written on this basis. The EDF and FRAMATOME codes are continuously improved; the results of a French set of separate effects experiments will be incorporated as well as integral system verification

Enforcement Alert: EPA Enforcement Efforts Focus on Prevention of Chemical Accidents

Science.gov (United States)

This Alert is intended to inform the industry that companies must take responsibility to prevent accidental releases of dangerous chemicals like anhydrous ammonia through compliance with CAA’s Chemical Accident Prevention Program.

Prevention of iron- and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters, L-DOPA, and curcumin: metal binding as a general antioxidant mechanism.

Science.gov (United States)

García, Carla R; Angelé-Martínez, Carlos; Wilkes, Jenna A; Wang, Hsiao C; Battin, Erin E; Brumaghim, Julia L

2012-06-07

Concentrations of labile iron and copper are elevated in patients with neurological disorders, causing interest in metal-neurotransmitter interactions. Catecholamine (dopamine, epinephrine, and norepinephrine) and amino acid (glycine, glutamate, and 4-aminobutyrate) neurotransmitters are antioxidants also known to bind metal ions. To investigate the role of metal binding as an antioxidant mechanism for these neurotransmitters, L-dihydroxyphenylalanine (L-DOPA), and curcumin, their abilities to prevent iron- and copper-mediated DNA damage were quantified, cyclic voltammetry was used to determine the relationship between their redox potentials and DNA damage prevention, and UV-vis studies were conducted to determine iron and copper binding as well as iron oxidation rates. In contrast to amino acid neurotransmitters, catecholamine neurotransmitters, L-DOPA, and curcumin prevent significant iron-mediated DNA damage (IC(50) values of 3.2 to 18 μM) and are electrochemically active. However, glycine and glutamate are more effective at preventing copper-mediated DNA damage (IC(50) values of 35 and 12.9 μM, respectively) than L-DOPA, the only catecholamine to prevent this damage (IC(50) = 73 μM). This metal-mediated DNA damage prevention is directly related to the metal-binding behaviour of these compounds. When bound to iron or copper, the catecholamines, amino acids, and curcumin significantly shift iron oxidation potentials and stabilize Fe(3+) over Fe(2+) and Cu(2+) over Cu(+), a factor that may prevent metal redox cycling in vivo. These results highlight the disparate antioxidant activities of neurotransmitters, drugs, and supplements and highlight the importance of considering metal binding when identifying antioxidants to treat and prevent neurodegenerative disorders.

Structural Integrity Assessment of VVER-1000 RPV under Accidental Cool down Transients

International Nuclear Information System (INIS)

Shrivastav, V.; Sen, R.N.; Yadav, R.S.

2012-01-01

Corrosion, Fatigue and Irradiation embrittlement are the major degradation mechanisms responsible for ageing of RPV (and its internals) of a Pressurized Water Reactor. While corrosion and fatigue can generate cracks, irradiation damage can lead to brittle fracture initiating from these cracks. Ageing in nuclear power plants needs to be managed so as to ensure that design functions remain available throughout the life of the plant. From safety perspective, this implies that ageing degradation of systems, structures and components important to safety remain within acceptable limits. Reactor Pressure Vessel has been identified as the highest priority key component in plant life management for Pressurized Water Reactors. Therefore special attention is required to ensure its structural integrity during its lifetime. In this paper, structural integrity assessment for typical VVER-1000 RPV is carried out under severe accidental cool down transients using the Finite Element Method. Three different accidental scenarios are postulated and safety of the vessel is conservatively assessed under these transients using the Linear Elastic Fracture Mechanics approach. Transient thermo mechanical stress analysis of the core belt region of the RPV is carried out in presence of postulated cracks and stress intensity factors are calculated and compared with the material fracture toughness to assess the structural integrity of the vessel. The paper also include some parametric analyses to justify the methodology. (author)

Accidental beam loss in superconducting accelerators: Simulations, consequences of accidents and protective measures

International Nuclear Information System (INIS)

Drozhdin, A.; Mokhov, N.; Parker, B.

1994-02-01

The consequences of an accidental beam loss in superconducting accelerators and colliders of the next generation range from the mundane to rather dramatic, i.e., from superconducting magnet quench, to overheating of critical components, to a total destruction of some units via explosion. Specific measures are required to minimize and eliminate such events as much as practical. In this paper we study such accidents taking the Superconducting Supercollider complex as an example. Particle tracking, beam loss and energy deposition calculations were done using the realistic machine simulation with the Monte-Carlo codes MARS 12 and STRUCT. Protective measures for minimizing the damaging effects of prefire and misfire of injection and extraction kicker magnets are proposed here

Causes of accidental childhood deaths in China in 2010

DEFF Research Database (Denmark)

Chan, Kit Yee; Yu, Xin-Wei; Lu, Jia-Peng

2015-01-01

-4 years in China, of which 31 633 (10.1%) were accidental. Accidental deaths contributed 7240 (4.0%) of all deaths in neonatal period, 8838 (10.5%) among all post-neonatal infant deaths, and 15 554 (31.7%) among children with 1-4 years of age. Among four tested models, the most predictive was used...

Doctor Ward's Accidental Terrarium.

Science.gov (United States)

Hershey, David R.

1996-01-01

Presents the story of the accidental invention of the Wardian case, or terrarium, by Nathaniel Bagshaw Ward. Advocates the use of this story in teaching precollege biology as an illustration of how a chance event can lead to a major scientific advancement and as an example of the common occurrence of multiple discovery in botany. Contains 34…

Sudden bilateral sensorineural hearing loss as an unusual consequence of accidental ingestion of potassium hydroxide.

Science.gov (United States)

Ciorba, A; Bovo, R; Castiglione, A; Pirodda, A; Martini, A

2010-01-01

To discuss the possible etiopathogenetic mechanism of inner ear damage induced by the ingestion of potassium hydroxide (KOH). We report the case of a 37-year-old patient with sudden bilateral sensorineural hearing loss after accidental ingestion of a KOH solution. The first ear, nose and throat examination disclosed only mild edema of the upper airways. He was treated in the intensive care unit and prescribed high-dose steroids, proton pump inhibitors and sucralfate for 2 weeks. Unfortunately, there was no recovery of the hearing loss, and no audiogram changes were noticed after 12 months of follow-up. After exploring the possible etiopathogenetic mechanism involved, the authors believe that in this case, a transient severe hemodynamic imbalance can actually be considered to be the most reliable explanation for the inner ear damage and subsequent onset of permanent bilateral sensorineural hearing loss. Copyright 2010 S. Karger AG, Basel.

SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts.

Science.gov (United States)

Xie, Xiaoxian; Wang, Liangliang; Zhao, Binggong; Chen, Yangyang; Li, Jiaqi

2017-05-15

Sirtuin 3 (SIRT3) is a mitochondria-specific protein required for the deacetylation of metabolic enzymes and the action of oxidative phosphorylation by acting as a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase. SIRT3 increases oxidative stress resistance and prevents mitochondrial decay associated with ageing in response to caloric restriction. However, the effects of SIRT3 on oxidative damage and ageing are not well understood. We investigated the physiological functions of porcine SIRT3 on the damage and ageing in porcine fetal fibroblasts (PFFs). Overexpression and knockdown of SIRT3 were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis, respectively. All cells were treated with three different stress reagents 12-o-tetradecanoylphorbol-13-acetate (TPA), methanesulfonic acid methylester (MMS), and tert-butylhydroperoxide (t-BHP), respectively, and then examined by flow cytometry following JC-1 (5, 5', 6, 6'-tetrachloro-1, 1', 3, 3'-tetraethylbenzimidazol-carbocyanine iodide) staining. SIRT3 overexpression enhanced the ability of superoxide dismutase 2 (SOD2) to reduce cellular reactive oxygen species (ROS), which further decreased the damage to the membranes and the organelles of the cells, especially to mitochondria. It inhibited the initial decrease of mitochondrial membrane potential, and prevented the decrease of adenosine triphosphate (ATP) production and activity of Nampt. In contrast, SIRT3 knockdown reduced the ability of SOD2 to increase cellular ROS which was directly correlated with stress-induced oxidative damage and ageing in PFFs. Our findings identify one function of SIRT3 in PFFs was to dampen cytotoxicity, and, therefore, to decrease oxidative damage and attenuate ageing possibly by enhancing the activity of SOD2. Copyright © 2017 Elsevier Inc. All rights reserved.

A preventive maintenance model for leased equipment subject to internal degradation and external shock damage

International Nuclear Information System (INIS)

Zhou, Xiaojun; Wu, Changjie; Li, Yanting; Xi, Lifeng

2016-01-01

A periodic preventive maintenance modeling method is proposed for leased equipment with continuous internal degradation and stochastic external shock damage considered simultaneously, which can facilitate the equipment lessor to optimize the maintenance schedule for the same kind of equipment rented by different lessees. A novel interactive mechanism between the continuous internal degradation and the stochastic external shock damage is established on the hazard rate of the equipment with integrating the imperfect effect of maintenance. Two improvement factors are defined for the modeling of imperfect maintenance. The number of failures resulting from internal degradation and from external shocks are both mathematically deduced based on this interactive mechanism. The optimal preventive maintenance scheme is obtained by minimizing the cumulative maintenance cost throughout the lease period. Numerical example shows that the proposed preventive maintenance model not only can reflect the reliability status of the equipment but also can clearly distinguish between the impact from internal degradation and that from external shocks. - Highlights: • We propose an imperfect periodic preventive maintenance model for leased equipment. • It can distinguish between the impact from internal degradation and that from external shocks. • An internal–external interactive mechanism is proposed. • Two improvement factors are introduced into the modeling of imperfect maintenance. • The model is helpful for the PM scheduling of the same equipment rented by different lessees.

Observaciones sobre accidentes de trabajo y enfermedades profesionales

Directory of Open Access Journals (Sweden)

Guillermo Sarmiento López

1948-03-01

Full Text Available En los tiempos antiguos no existía ley ni disposición alguna de carácter social que favoreciera a los trabajadores incapacitados por enfermedad o por accidente, por tanto, eran tratados como esclavos o considerados como animales. Los accidentes de trabajo y las enfermedades profesionales eran casi desconocidas antes de la introducción de la maquinaria en la industria, por lo cual no existía el derecho a indemnización por concepto de daños que sufriera el trabajador en el desempeño de sus labores. Solamente se conocen los edictos de Rotari (año 645 de la éra cristiana lanzados en Italia con el fin de reparar los accidentes de los obreros de la construcción y después, en la época del Renacimiento, algunas publicaciones que hablan de ciertas enfermedades de los trabajadores (Ellemborg 1473, Paracelso 1493-1541. Ya en la edad media la industria comenzó a tomar cierta importancia y dada la escasez de brazos, se vio obligado el patrón por fuerza de las circunstancias a prestar ayuda económica a los trabajadores incapacitados por una u otra causa. Los accidentes sucedidos en las industrias no se consideraban como de trabajo, por no conocerse el peligro que envolvía el empleo de la maqumana. En el siglo XVII y a principios del XVIII un médico italiano, Ramazzini habla del perjuicio que ocasionan ciertos trabajos en el organismo del individuo, produciendo alteraciones anatómicas y funcionales. Solamente a fines del siglo XVIII y a principios del XIX con la producción en masa, con el aumento del número de obreros y con la falta de protección, empezaron los accidentes de trabajo a hacerse notorios.

Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

Directory of Open Access Journals (Sweden)

Vilma Sousa Santana

2013-01-01

Full Text Available En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por causas externas, 31.576 (2,3% por accidentes de trabajo y solo 226 (0,02% por accidentes de trabajo con violen- cia interpersonal. Cerca del 80% de los informes estadísticos de defunción no tenían el campo “accidente de trabajo” completado. La mayor cantidad de casos ocurrió entre hom- bres (94,3% de 25-34 años, con nivel de escolaridad medio, ubicados en la región sudeste y noreste, que trabajan principalmente en la producción de bienes y servicios industriales y la actividad agropecuaria. La mayoría de los casos fueron causados por armas de fuego, seguidos por armas blancas, con un aumento relativo de estos últimos en el período estu- diado. Los resultados sugieren un gran subregistro de diagnósticos que reconocen la rela- ción con el trabajo. Se hace necesaria una mejor capacitación en el llenado de los informes estadísticos, así como estudios que cuantifiquen el subregistro de accidentes de trabajo y accidentes de trabajo con violencia interpersonal.

Preventive measures against concrete damage to ASR in the Netherlands current state-of-affairs

NARCIS (Netherlands)

Heijnen, W.M.M.; Larbi, J.A.

1999-01-01

In CUR-Recommendation 38, various vital measures that need to be taken during design of new concrete-mixtures in order to prevent damage due to ASR in the concrete have been outlined. The most important of these measures are: - the use of blast furnace slag cement (with a high slag content: ≥50% by

Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation

International Nuclear Information System (INIS)

Yamamoto, Tetsuo; Kinoshita, Manabu; Shinomiya, Nariyoshi; Hiroi, Sadayuki; Sugasawa, Hidekazu; Majima, Takashi; Seki, Shuhji; Matsushita, Yoshitaro; Saitoh, Daizoh

2010-01-01

While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and then the mice underwent whole body irradiation (WBI). Bone marrow transplantation (BMT) 24 h after irradiation rescued mice receiving a WBI dose of less than 12 Gy. No mice receiving 14 Gy-WBI survived, because of radiation-induced GI syndrome, even if they received BMT. However, pretreatment with ascorbic acid significantly suppressed radiation-induced DNA damage in the crypt cells and prevented denudation of intestinal mucosa; therefore, ascorbic acid in combination with BMT rescued mice after 14 Gy-WBI. DNA microarray analysis demonstrated that irradiation up-regulated expressions of apoptosis-related genes in the small intestine, including those related to the caspase-9-mediated intrinsic pathway as well as the caspase-8-mediated extrinsic pathway, and down-regulated expressions of these genes in ascorbic acid-pretreated mice. Thus, pretreatment with ascorbic acid may effectively prevent radiation-induced GI syndrome. (author)

Static and mobile networks design for atmospheric accidental releases monitoring

International Nuclear Information System (INIS)

Abida, R.

2010-01-01

The global context of my PhD thesis work is the optimization of air pollution monitoring networks, but more specifically it concerns the monitoring of accidental releases of radionuclides in air. The optimization problem of air quality measuring networks has been addresses in the literature. However, it has not been addresses in the context of surveillance of accidental atmospheric releases. The first part of my thesis addresses the optimization of a permanent network of monitoring of radioactive aerosols in the air, covering France. The second part concerns the problem of targeting of observations in case of an accidental release of radionuclides from a nuclear plant. (author)

Numerical research of a super-large cooling tower subjected to accidental loads

Energy Technology Data Exchange (ETDEWEB)

Li, Yi; Lin, Feng [Department of Building Engineering, Tongji University, Shanghai 200092 (China); Gu, Xianglin, E-mail: gxl@tongji.edu.cn [Department of Building Engineering, Tongji University, Shanghai 200092 (China); Lu, Xiaoqin [Guangdong Electric Power Design Institute, Guangzhou 510660 (China)

2014-04-01

With the continued development of nuclear power plants, more and more super-large cooling towers are to be built in China and around the world. For the safe operation of nuclear power plants, research work has been done on the causes of collapse of cooling towers, collapse modes and the secondary disasters caused by the collapse of cooling towers. However, the collapse modes and the ground vibration induced by the collapse of cooling towers subjected to the accidental loads have not been fully understood. This paper has been focused on the modes and mechanisms behavior of the collapse of cooling towers subjected to accidental loads. Meanwhile, prediction of the ground vibration due to the collapse of the cooling towers has also been completed in a parallel project. Using dynamic finite element program LS-DYNA, a 3D finite element model for a super-large cooling tower was developed and the nonlinear material models were incorporated. In this paper, four types of accidental loads were considered to trigger the collapse or local failure of the tower, including vehicle collision, airplane impact, local explosion and missile attack. It was found that vehicle collision, missile attack and small TNT equivalent explosives (2 kg, 20 kg, 200 kg) might result in local failure of the cooling tower, however, the tower can still keep stable. On the other hand, large TNT equivalent explosives (2000 kg, 4500 kg) could cause severe damages in the inclined columns of the cooling tower, and lead to progressive collapse of the entire cooling tower. The two kinds of TNT equivalent explosives caused the same collapse mode while the collapsing duration was different. The airplane impacted at the throat of the cooling tower caused the local failure of shell structure of the tower, and then the progressive collapse of the cooling tower happened due to the gravitational action. The resulting collapse mode was different from that triggered by the local explosion.

Numerical research of a super-large cooling tower subjected to accidental loads

International Nuclear Information System (INIS)

Li, Yi; Lin, Feng; Gu, Xianglin; Lu, Xiaoqin

2014-01-01

With the continued development of nuclear power plants, more and more super-large cooling towers are to be built in China and around the world. For the safe operation of nuclear power plants, research work has been done on the causes of collapse of cooling towers, collapse modes and the secondary disasters caused by the collapse of cooling towers. However, the collapse modes and the ground vibration induced by the collapse of cooling towers subjected to the accidental loads have not been fully understood. This paper has been focused on the modes and mechanisms behavior of the collapse of cooling towers subjected to accidental loads. Meanwhile, prediction of the ground vibration due to the collapse of the cooling towers has also been completed in a parallel project. Using dynamic finite element program LS-DYNA, a 3D finite element model for a super-large cooling tower was developed and the nonlinear material models were incorporated. In this paper, four types of accidental loads were considered to trigger the collapse or local failure of the tower, including vehicle collision, airplane impact, local explosion and missile attack. It was found that vehicle collision, missile attack and small TNT equivalent explosives (2 kg, 20 kg, 200 kg) might result in local failure of the cooling tower, however, the tower can still keep stable. On the other hand, large TNT equivalent explosives (2000 kg, 4500 kg) could cause severe damages in the inclined columns of the cooling tower, and lead to progressive collapse of the entire cooling tower. The two kinds of TNT equivalent explosives caused the same collapse mode while the collapsing duration was different. The airplane impacted at the throat of the cooling tower caused the local failure of shell structure of the tower, and then the progressive collapse of the cooling tower happened due to the gravitational action. The resulting collapse mode was different from that triggered by the local explosion

Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro.

Science.gov (United States)

Schmid, Ursula; Stopper, Helga; Heidland, August; Schupp, Nicole

2008-01-01

Complications in diabetes mellitus are partially mediated by enhanced formation of reactive oxygen species. Among the factors involved in reactive oxygen species formation, advanced glycation end products play a key role. Owing to a reduced activity of the enzyme transketolase, which requires diphosphorylated thiamine (vitamin B(1)) as cofactor, an accumulation of those deleterious glucose metabolites especially in diabetic patients can be observed. Benfotiamine, a lipophilic thiamine diphosphate prodrug, prevented early renal and retinal changes in animal studies, and reduced neuropathic pain in clinical studies. Several mechanisms for these activities have been described. We investigated for the first time direct antioxidant abilities of benfotiamine. Additionally, a potential DNA protective effect of benfotiamine was analysed. Oxidative stress was detected by flow cytometry, antioxidative capacity was measured with the ferric reducing ability of plasma (FRAP) assay, two endpoints for genomic damage were assessed: the comet assay and the micronucleus test, and the expression and activity of transketolase was quantified. Benfotiamine prevented oxidative stress induced by the mutagen 4-nitroquinoline-1-oxide (NQO), the uremic toxin indoxyl sulfate, and the peptide hormone angiotensin II in three different kidney cell lines. Cell-free experiments showed a direct antioxidant effect of benfotiamine, which might account for the protective effect. Oxidative DNA damage, induced by angiotensin II, was completely prevented by benfotiamine. Incubation with benfotiamine increased transketolase expression and activity in the cells. Benfotiamine shows a direct antioxidant action. This effect of benfotiamine may be involved in the improvement of diabetic late complications, including peripheral neuropathy.

An Experimental Investigation On Minimum Compressive Strength Of Early Age Concrete To Prevent Frost Damage For Nuclear Power Plant Structures In Cold Climates

International Nuclear Information System (INIS)

Koh, Kyungtaek; Kim, Dogyeum; Park, Chunjin; Ryu, Gumsung; Park, Jungjun; Lee, Janghwa

2013-01-01

Concrete undergoing early frost damage in cold weather will experience significant loss of not only strength, but also of permeability and durability. Accordingly, concrete codes like ACI-306R prescribe a minimum compressive strength and duration of curing to prevent frost damage at an early age and secure the quality of concrete. Such minimum compressive strength and duration of curing are mostly defined based on the strength development of concrete. However, concrete subjected to frost damage at early age may not show a consistent relationship between its strength and durability. Especially, since durability of concrete is of utmost importance in nuclear power plant structures, this relationship should be imperatively clarified. Therefore, this study verifies the feasibility of the minimum compressive strength specified in the codes like ACI-306R by evaluating the strength development and the durability preventing the frost damage of early age concrete for nuclear power plant. The results indicate that the value of 5 MPa specified by the concrete standards like ACI-306R as the minimum compressive strength to prevent the early frost damage is reasonable in terms of the strength development, but seems to be inappropriate in the viewpoint of the resistance to chloride ion penetration and freeze-thaw. Consequently, it is recommended to propose a minimum compressive strength preventing early frost damage in terms of not only the strength development, but also in terms of the durability to secure the quality of concrete for nuclear power plants in cold climates

An Experimental Investigation On Minimum Compressive Strength Of Early Age Concrete To Prevent Frost Damage For Nuclear Power Plant Structures In Cold Climates

Energy Technology Data Exchange (ETDEWEB)

Koh, Kyungtaek; Kim, Dogyeum; Park, Chunjin; Ryu, Gumsung; Park, Jungjun; Lee, Janghwa [Korea Institute Construction Technology, Goyang (Korea, Republic of)

2013-06-15

Concrete undergoing early frost damage in cold weather will experience significant loss of not only strength, but also of permeability and durability. Accordingly, concrete codes like ACI-306R prescribe a minimum compressive strength and duration of curing to prevent frost damage at an early age and secure the quality of concrete. Such minimum compressive strength and duration of curing are mostly defined based on the strength development of concrete. However, concrete subjected to frost damage at early age may not show a consistent relationship between its strength and durability. Especially, since durability of concrete is of utmost importance in nuclear power plant structures, this relationship should be imperatively clarified. Therefore, this study verifies the feasibility of the minimum compressive strength specified in the codes like ACI-306R by evaluating the strength development and the durability preventing the frost damage of early age concrete for nuclear power plant. The results indicate that the value of 5 MPa specified by the concrete standards like ACI-306R as the minimum compressive strength to prevent the early frost damage is reasonable in terms of the strength development, but seems to be inappropriate in the viewpoint of the resistance to chloride ion penetration and freeze-thaw. Consequently, it is recommended to propose a minimum compressive strength preventing early frost damage in terms of not only the strength development, but also in terms of the durability to secure the quality of concrete for nuclear power plants in cold climates.

Accidental Ingestion of Instruments in Pediatric Dental Patients: Report of Three Cases

Directory of Open Access Journals (Sweden)

Amey Panse

2012-01-01

Full Text Available Very young children are at risk of swallowing or aspirating numerous household things. This risk is enhanced during dental procedures of these children as they tend to be very unco-operative due to their age and lack of maturity to understand the importance of the treatment. Use of physical barriers, sedation or general anesthesia is not practically possible in every child scheduled for dental treatment. Dentist must be able to manage emergency situations in which patients accidentally swallow dental instruments or materials during treatment and procedures. This article presents ingestion of dental objects in 3 children and attempts to discuss the management and prevention of such mishaps.

Epicardial Ablation: Prevention of Phrenic Nerve Damage by Pericardial Injection of Saline and the Use of a Steerable Sheath

Directory of Open Access Journals (Sweden)

Kars Neven, MD

2014-03-01

Full Text Available Because of the close proximity of the phrenic nerve to the pericardium, phrenic nerve damage caused by epicardial ablation can easily occur. We report two cases of epicardial VT ablation where pericardial injection of saline, combined with the use of a steerable sheath, successfully prevents the phrenic nerve from being damaged.

Prevention of DNA damage and anticarcinogenic activity of Activia® in a preclinical model.

Science.gov (United States)

Limeiras, S M A; Ogo, F M; Genez, L A L; Carreira, C M; Oliveira, E J T; Pessatto, L R; Neves, S C; Pesarini, J R; Schweich, L C; Silva, R A; Cantero, W B; Antoniolli-Silva, A C M B; Oliveira, R J

2017-03-22

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

A damage mechanics based approach to structural deterioration and reliability

Energy Technology Data Exchange (ETDEWEB)

Bhattcharya, B.; Ellingwood, B. [Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Civil Engineering

1998-02-01

Structural deterioration often occurs without perceptible manifestation. Continuum damage mechanics defines structural damage in terms of the material microstructure, and relates the damage variable to the macroscopic strength or stiffness of the structure. This enables one to predict the state of damage prior to the initiation of a macroscopic flaw, and allows one to estimate residual strength/service life of an existing structure. The accumulation of damage is a dissipative process that is governed by the laws of thermodynamics. Partial differential equations for damage growth in terms of the Helmholtz free energy are derived from fundamental thermodynamical conditions. Closed-form solutions to the equations are obtained under uniaxial loading for ductile deformation damage as a function of plastic strain, for creep damage as a function of time, and for fatigue damage as function of number of cycles. The proposed damage growth model is extended into the stochastic domain by considering fluctuations in the free energy, and closed-form solutions of the resulting stochastic differential equation are obtained in each of the three cases mentioned above. A reliability analysis of a ring-stiffened cylindrical steel shell subjected to corrosion, accidental pressure, and temperature is performed.

A damage mechanics based approach to structural deterioration and reliability

International Nuclear Information System (INIS)

Bhattcharya, B.; Ellingwood, B.

1998-02-01

Structural deterioration often occurs without perceptible manifestation. Continuum damage mechanics defines structural damage in terms of the material microstructure, and relates the damage variable to the macroscopic strength or stiffness of the structure. This enables one to predict the state of damage prior to the initiation of a macroscopic flaw, and allows one to estimate residual strength/service life of an existing structure. The accumulation of damage is a dissipative process that is governed by the laws of thermodynamics. Partial differential equations for damage growth in terms of the Helmholtz free energy are derived from fundamental thermodynamical conditions. Closed-form solutions to the equations are obtained under uniaxial loading for ductile deformation damage as a function of plastic strain, for creep damage as a function of time, and for fatigue damage as function of number of cycles. The proposed damage growth model is extended into the stochastic domain by considering fluctuations in the free energy, and closed-form solutions of the resulting stochastic differential equation are obtained in each of the three cases mentioned above. A reliability analysis of a ring-stiffened cylindrical steel shell subjected to corrosion, accidental pressure, and temperature is performed

3 CFR 8352 - Proclamation 8352 of March 13, 2009. National Poison Prevention Week, 2009

Science.gov (United States)

2010-01-01

... about preventing and responding to poisonings. This education effort is critical to the well-being of... accidental poisonings and to take appropriate preventive measures, the Congress, by joint resolution approved...

Youth versus adult "weightlifting" injuries presenting to United States emergency rooms: accidental versus nonaccidental injury mechanisms.

Science.gov (United States)

Myer, Gregory D; Quatman, Carmen E; Khoury, Jane; Wall, Eric J; Hewett, Timothy E

2009-10-01

Resistance training has previously been purported to be unsafe and ineffective in children. The purpose of this investigation was to evaluate resistance training-related injuries presenting to U.S. emergency rooms by age, type, and mechanism of injury. We hypothesized that older athletes would sustain greater percentages of joint sprains and muscle strains, whereas younger athletes would sustain a greater percentage of accidental injuries that would result in an increased percentage of fractures in youths. The U.S. Consumer Product Safety Commission (CPSC) National Electronic Injury Surveillance System was queried from 2002 to 2005 using the CPSC code for "Weightlifting." Subjects between the ages of 8 and 30 were grouped by age categories 8 to 13 (elementary/middle school age), 14 to 18 (high school), 19 to 22 (college), and 23 to 30 (adult). Injuries were classified as "accidental" if caused by dropped weight or improper equipment use. Multiple logistic regression was used to compare accidental injuries between age groups. The sample consisted of 4,111 patients. Accidental injuries decreased (p 14 to 18 > 19 to 22 years = 23 to 30 years. Conversely, sprain/strain injuries increased in each successive age group (p injuries (n = 2,565) showed that the oldest categories (19-22 and 23-30 yr) demonstrated a greater percentage of sprains and strains relative to younger age categories (p injuries sustained in the 8 to 13 group were to the hand and foot and were most often related to "dropping" and "pinching" in the injury descriptions, and there was an increased percentage of fractures in the 8 to 13 group relative to all other groups (p injuries are the result of accidents that are potentially preventable with increased supervision and stricter safety guidelines.

Integrity Analysis of Damaged Steam Generator Tubes

International Nuclear Information System (INIS)

Stanic, D.

1998-01-01

Variety of degradation mechanisms affecting steam generator tubes makes steam generators as one of the critical components in the nuclear power plants. Depending of their nature, degradation mechanisms cause different types of damages. It requires performance of extensive integrity analysis in order to access various conditions of crack behavior under operating and accidental conditions. Development and application of advanced eddy current techniques for steam generator examination provide good characterization of found damages. Damage characteristics (shape, orientation and dimensions) may be defined and used for further evaluation of damage influence on tube integrity. In comparison with experimental and analytical methods, numerical methods are also efficient tools for integrity assessment. Application of finite element methods provides relatively simple modeling of different type of damages and simulation of various operating conditions. The stress and strain analysis may be performed for elastic and elasto-plastic state with good ability for visual presentation of results. Furthermore, the fracture mechanics parameters may be calculated. Results obtained by numerical analysis supplemented with experimental results are the base for definition of alternative plugging criteria which may significantly reduce the number of plugged tubes. (author)

Patterns and Trends in Accidental Poisoning Deaths: Pennsylvania's Experience 1979-2014.

Directory of Open Access Journals (Sweden)

Lauren C Balmert

Full Text Available The purpose of this study was to examine county and state-level accidental poisoning mortality trends in Pennsylvania from 1979 to 2014.Crude and age-adjusted death rates were formed for age group, race, sex, and county for accidental poisonings (ICD 10 codes X40-X49 from 1979 to 2014 for ages 15+ using the Mortality and Population Data System housed at the University of Pittsburgh. Rate ratios were calculated comparing rates from 1979 to 2014, overall and by sex, age group, and race. Joinpoint regression was used to detect statistically significant changes in trends of age-adjusted mortality rates.Rate ratios for accidental poisoning mortality in Pennsylvania increased more than 14-fold from 1979 to 2014. The largest rate ratios were among 35-44 year olds, females, and White adults. The highest accidental poisoning mortality rates were found in the counties of Southwestern Pennsylvania, those surrounding Philadelphia, and those in Northeast Pennsylvania near Scranton.The patterns and locations of accidental poisoning mortality by race, sex, and age group provide direction for interventions and policy makers. In particular, this study found the highest rate ratios in PA among females, whites, and the age group 35-44.

Individual housing-based socioeconomic status predicts risk of accidental falls among adults.

Science.gov (United States)

Ryu, Euijung; Juhn, Young J; Wheeler, Philip H; Hathcock, Matthew A; Wi, Chung-Il; Olson, Janet E; Cerhan, James R; Takahashi, Paul Y

2017-07-01

Accidental falls are a major public health concern among people of all ages. Little is known about whether an individual-level housing-based socioeconomic status measure is associated with the risk of accidental falls. Among 12,286 Mayo Clinic Biobank participants residing in Olmsted County, Minnesota, subjects who experienced accidental falls between the biobank enrollment and September 2014 were identified using ICD-9 codes evaluated at emergency departments. HOUSES (HOUsing-based Index of SocioEconomic Status), a socioeconomic status measure based on individual housing features, was also calculated. Cox regression models were utilized to assess the association of the HOUSES (in quartiles) with accidental fall risk. Seven hundred eleven (5.8%) participants had at least one emergency room visit due to an accidental fall during the study period. Subjects with higher HOUSES were less likely to experience falls in a dose-response manner (hazard ratio: 0.58; 95% confidence interval: 0.44-0.76 for comparing the highest to the lowest quartile). In addition, the HOUSES was positively associated with better health behaviors, social support, and functional status. The HOUSES is inversely associated with accidental fall risk requiring emergency care in a dose-response manner. The HOUSES may capture falls-related risk factors through housing features and socioeconomic status-related psychosocial factors. Copyright © 2017 Elsevier Inc. All rights reserved.

Reducing the loss of vaccines from accidental freezing in the cold chain: the experience of continuous temperature monitoring in Tunisia.

Science.gov (United States)

Lloyd, John; Lydon, Patrick; Ouhichi, Ramzi; Zaffran, Michel

2015-02-11

Accidental freezing of vaccines is a growing threat and a real risk for national immunization programs when the potency of many vaccines can be compromised if these are exposed to sub-zero temperatures in the cold chain. In Tunisia, this issue is compounded by using sub-standard domestic cold chain equipment instead of equipping the program with medical refrigerators designed specifically for storing vaccines and temperature sensitive pharmaceuticals. Against this backdrop, this paper presents the findings of a demonstration project conducted in Tunisia in 2012 that tested the impact of introducing several freeze prevention solutions to mitigate the risk of accidental freezing of vaccines. The main finding is that, despite the continued use of underperforming domestic refrigerators, continuous temperature monitoring using new technologies combined with other technological interventions significantly reduced the prevalence of accidental exposure to freezing temperatures. These improvements were noticed for cold chain storage at regional, district and health center levels, and during the transport legs that were part of the demonstration conducted in the regions of Kasserine in the South-Eastern part of Tunisia. Subsequent to introducing these freeze prevention solutions, the incidence of freeze alarms was reduced and the percent of time the temperatures dropped below the 2 °C recommended threshold. The incidence of freeze alarms at health center level was reduced by 40%. Lastly, the solutions implemented reduced risk of freezing during transport from 13.8% to 1.7%. Although the solution implemented is not optimal in the longer term because domestic refrigerators are used extensively in district stores and health centers, the risk of accidental freezing is significantly reduced by introducing the practice of continuous temperature monitoring as a standard. The management of the cold chain equipment was strengthened as a result which helps protect the potency of

Vitamin C for DNA damage prevention

International Nuclear Information System (INIS)

Sram, Radim J.; Binkova, Blanka; Rossner, Pavel

2012-01-01

The ability of vitamin C to affect genetic damage was reviewed in human studies that used molecular epidemiology methods, including analysis of DNA adducts, DNA strand breakage (using the Comet assay), oxidative damage measured as levels of 8-oxo-7,8-dihydroxy-2′-deoxyguanosine (8-oxodG), cytogenetic analysis of chromosomal aberrations and micronuclei, and the induction of DNA repair proteins. The protective effect of vitamin C was observed at plasma levels > 50 μmol/l. Vitamin C supplementation decreased the frequency of chromosomal aberrations in groups with insufficient dietary intake who were occupationally exposed to mutagens, and also decreased the sensitivity to mutagens as assessed using the bleomycin assay. High vitamin C levels in plasma decreased the frequency of genomic translocations in groups exposed to ionizing radiation or c-PAHs in polluted air. The frequency of micronuclei was decreased by vitamin C supplementation in smokers challenged with γ-irradiation, and higher vitamin C levels in plasma counteracted the damage induced by air pollution. The prevalence of DNA adducts inversely correlated with vitamin C levels in groups environmentally exposed to high concentrations of c-PAHs. Increased vitamin C levels decreased DNA strand breakage induced by air pollution. Oxidative damage (8-oxodG levels) was decreased by vitamin C supplementation in groups with plasma levels > 50 μmol/l exposed to PM2.5 and c-PAHs. Modulation of DNA repair by vitamin C supplementation was observed both in poorly nourished subjects and in groups with vitamin C plasma levels > 50 μmol/l exposed to higher concentrations of c-PAHs. It is possible that the impact of vitamin C on DNA damage depends both on background values of vitamin C in the individual as well as on the level of exposure to xenobiotics or oxidative stress.

Vitamin C for DNA damage prevention

Energy Technology Data Exchange (ETDEWEB)

Sram, Radim J., E-mail: sram@biomed.cas.cz [Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague 4 (Czech Republic); Binkova, Blanka; Rossner, Pavel [Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague 4 (Czech Republic)

2012-05-01

The ability of vitamin C to affect genetic damage was reviewed in human studies that used molecular epidemiology methods, including analysis of DNA adducts, DNA strand breakage (using the Comet assay), oxidative damage measured as levels of 8-oxo-7,8-dihydroxy-2 Prime -deoxyguanosine (8-oxodG), cytogenetic analysis of chromosomal aberrations and micronuclei, and the induction of DNA repair proteins. The protective effect of vitamin C was observed at plasma levels > 50 {mu}mol/l. Vitamin C supplementation decreased the frequency of chromosomal aberrations in groups with insufficient dietary intake who were occupationally exposed to mutagens, and also decreased the sensitivity to mutagens as assessed using the bleomycin assay. High vitamin C levels in plasma decreased the frequency of genomic translocations in groups exposed to ionizing radiation or c-PAHs in polluted air. The frequency of micronuclei was decreased by vitamin C supplementation in smokers challenged with {gamma}-irradiation, and higher vitamin C levels in plasma counteracted the damage induced by air pollution. The prevalence of DNA adducts inversely correlated with vitamin C levels in groups environmentally exposed to high concentrations of c-PAHs. Increased vitamin C levels decreased DNA strand breakage induced by air pollution. Oxidative damage (8-oxodG levels) was decreased by vitamin C supplementation in groups with plasma levels > 50 {mu}mol/l exposed to PM2.5 and c-PAHs. Modulation of DNA repair by vitamin C supplementation was observed both in poorly nourished subjects and in groups with vitamin C plasma levels > 50 {mu}mol/l exposed to higher concentrations of c-PAHs. It is possible that the impact of vitamin C on DNA damage depends both on background values of vitamin C in the individual as well as on the level of exposure to xenobiotics or oxidative stress.

Pathophysiology of repetitive head injury in sports. Prevention against catastrophic brain damage

International Nuclear Information System (INIS)

Mori, Tatsuro; Kawamata, Tatsuro; Katayama, Yoichi

2008-01-01

The most common head injury in sports is concussion and experiencing multiple concussions in a short period of time sometimes can cause severe brain damage. In this paper, we investigate severe brain damage due to repeated head injury in sports and discuss the pathophysiology of repeated sports injury. The majority of these severe cases are usually male adolescents or young adults that suffer a second head injury before they have recovered from the first head injury. All cases that could be confirmed by brain CT scan after the second injury revealed brain swelling associated with a thin subdural hematoma. We suggested that the existence of subdural hematoma is one of the major causes of brain swelling after repeated head injury in sports. Since repeated concussions occurring within a short period may have a risk for severe brain damage, the diagnosis for initial cerebral concussion should be done appropriately. To prevent catastrophic brain damage, the player who suffered from concussion should not engage in any sports before recovery. The american Academy of Neurology and Colorado Medical Society set a guideline to return to play after cerebral concussion. An international conference on concussion in sports was held at Prague in 2004. The summary and agreement of this meeting was published and the Sports Concussion Assessment Tool (SCAT) was introduced to treat sports-related concussion. In addition, a number of computerized cognitive assessment tests and test batteries have been developed to allow athletes to return to play. It is important that coaches, as well as players and trainers, understand the medical issues involved in concussion. (author)

Accidental Innovation

DEFF Research Database (Denmark)

Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

2012-01-01

Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

Hybrid parallel strategy for the simulation of fast transient accidental situations at reactor scale

International Nuclear Information System (INIS)

Faucher, V.; Galon, P.; Beccantini, A.; Crouzet, F.; Debaud, F.; Gautier, T.

2015-01-01

Highlights: • Reference accidental situations for current and future reactors are considered. • They require the modeling of complex fluid–structure systems at full reactor scale. • EPX software computes the non-linear transient solution with explicit time stepping. • Focus on the parallel hybrid solver specific to the proposed coupled equations. - Abstract: This contribution is dedicated to the latest methodological developments implemented in the fast transient dynamics software EUROPLEXUS (EPX) to simulate the mechanical response of fully coupled fluid–structure systems to accidental situations to be considered at reactor scale, among which the Loss of Coolant Accident, the Core Disruptive Accident and the Hydrogen Explosion. Time integration is explicit and the search for reference solutions within the safety framework prevents any simplification and approximations in the coupled algorithm: for instance, all kinematic constraints are dealt with using Lagrange Multipliers, yielding a complex flow chart when non-permanent constraints such as unilateral contact or immersed fluid–structure boundaries are considered. The parallel acceleration of the solution process is then achieved through a hybrid approach, based on a weighted domain decomposition for distributed memory computing and the use of the KAAPI library for self-balanced shared memory processing inside subdomains

Accidental symmetries and the effective Lagrangian of string theory

International Nuclear Information System (INIS)

Ovrut, B.A.

1989-01-01

In this paper the relationship between accidental worldsheet symmetries of the string generating functional and target space invariance groups is discussed. Accidental symmetries are used to derive the invariance groups and effective low energy Lagrangian for the bosonic string, and the heterotic string compactified to four-dimensions on Z N orbifolds. The necessity of a new type of Green-Schwarz mechanism, associated with the auxiliary vector field in the four-dimensional N = 1 supergravity multiplet, is shown using these methods

Prevention Effect of Poly-Gamma-Glutamic Acid on Tissue Damage Induced by Gamma Irradiation as a Natural Cross-Linker

Energy Technology Data Exchange (ETDEWEB)

Kim, Jaehun; Sung, Nakyun; Kim, Jeongsoo; Jo, Euri; Choi, Jongil; Park, Jongheum; Lee, Juwoon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Kwangwon [Eulji Univ. Hospital, Daejeon (Korea, Republic of); Kwon, Jungkee [Chonbuk National Univ., Jeonju (Korea, Republic of); Kim, Taewoon [Jeonbuk Technopark, Jeonju (Korea, Republic of)

2012-03-15

This study was to determine the prevention effect of poly-gamma-glutamic acid (PGA) on tissue damage induced by gamma irradiation for development of xenograft. PGA (MW 2000 kDa) extracted from permeated soy bean (natto) was used in this study as natural compound, and glutaraldehyde (GA) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were used as a control, chemical based cross-linking agents. GA, EDC and PGA treated porcine tendons were gamma-irradiated at the dose of 30 kGy. Prevention effects against tissue damage were measured as the result of tensile strength, hydroxyproline contents and tissue morphological analysis. Tensile of porcine tendon was remarkably decreased by gamma irradiation, but increased in PGA treated group. Morphological analysis showed that collagen structure was broken by gamma irradiation, but attenuated by PGA treatment. Base on the results, it demonstrated that gamma irradiation can induce severe alteration of porcine tendon, but PGA can effectively improve the tissue damage.

Prevention Effect of Poly-Gamma-Glutamic Acid on Tissue Damage Induced by Gamma Irradiation as a Natural Cross-Linker

International Nuclear Information System (INIS)

Kim, Jaehun; Sung, Nakyun; Kim, Jeongsoo; Jo, Euri; Choi, Jongil; Park, Jongheum; Lee, Juwoon; Lee, Kwangwon; Kwon, Jungkee; Kim, Taewoon

2012-01-01

This study was to determine the prevention effect of poly-gamma-glutamic acid (PGA) on tissue damage induced by gamma irradiation for development of xenograft. PGA (MW 2000 kDa) extracted from permeated soy bean (natto) was used in this study as natural compound, and glutaraldehyde (GA) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) were used as a control, chemical based cross-linking agents. GA, EDC and PGA treated porcine tendons were gamma-irradiated at the dose of 30 kGy. Prevention effects against tissue damage were measured as the result of tensile strength, hydroxyproline contents and tissue morphological analysis. Tensile of porcine tendon was remarkably decreased by gamma irradiation, but increased in PGA treated group. Morphological analysis showed that collagen structure was broken by gamma irradiation, but attenuated by PGA treatment. Base on the results, it demonstrated that gamma irradiation can induce severe alteration of porcine tendon, but PGA can effectively improve the tissue damage

Targeted Delivery of Neutralizing Anti-C5 Antibody to Renal Endothelium Prevents Complement-Dependent Tissue Damage

Directory of Open Access Journals (Sweden)

Paolo Durigutto

2017-09-01

Full Text Available Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process. To this end, we generated Ergidina, a neutralizing recombinant anti-C5 human antibody coupled with a cyclic-RGD peptide, with a distinctive homing property for ischemic endothelial cells and effective in controlling tissue damage in a rat model of renal ischemia/reperfusion injury (IRI. As a result of its preferential localization on renal endothelium, the molecule induced complete inhibition of complement activation at tissue level, and local protection from complement-mediated tissue damage without affecting circulating C5. The ex vivo binding of Ergidina to surgically removed kidney exposed to cold ischemia supports its therapeutic use to prevent posttransplant IRI leading to delay of graft function. Moreover, the finding that the ex vivo binding of Ergidina was not restricted to the kidney, but was also seen on ischemic heart, suggests that this RGD-targeted anti-C5 antibody may represent a useful tool to treat organs prior to transplantation. Based on this evidence, we propose preliminary data showing that Ergidina is a novel targeted drug to prevent complement activation on the endothelium of ischemic kidney.

Night work, long work weeks, and risk of accidental injuries. A register-based study.

Science.gov (United States)

Larsen, Ann D; Hannerz, Harald; Møller, Simone V; Dyreborg, Johnny; Bonde, Jens Peter; Hansen, Johnni; Kolstad, Henrik A; Hansen, Åse Marie; Garde, Anne Helene

2017-11-01

Objectives The aims of this study were to (i) investigate the association between night work or long work weeks and the risk of accidental injuries and (ii) test if the association is affected by age, sex or socioeconomic status. Methods The study population was drawn from the Danish version of the European Labour Force Survey from 1999-2013. The current study was based on 150 438 participants (53% men and 47% women). Data on accidental injuries were obtained at individual level from national health registers. We included all 20-59-year-old employees working ≥32 hours a week at the time of the interview. We used Poisson regression to estimate the relative rates (RR) of accidental injuries as a function of night work or long work weeks (>40 hours per week) adjusted for year of interview, sex, age, socioeconomic status (SES), industry, and weekly working hours or night work. Age, sex and SES were included as two-way interactions. Results We observed 23 495 cases of accidental injuries based on 273 700 person years at risk. Exposure to night work was statistically significantly associated with accidental injuries (RR 1.11, 99% CI 1.06-1.17) compared to participants with no recent night work. No associations were found between long work weeks (>40 hours) and accidental injuries. Conclusion We found a modest increased risk of accidental injuries when reporting night work. No associations between long work weeks and risk of accidental injuries were observed. Age, sex and SES showed no trends when included as two-way interactions.

Los hombres y los accidentes de tránsito: un vistazo al riesgo, conducta de riesgo, notificación de accidentes, educación y formación profesional

Directory of Open Access Journals (Sweden)

Cintia Rodrigues

2017-05-01

Full Text Available Abstract Los accidentes de tránsito son un grave y complejo problema de salud pública. La literatura señala que los accidentes de tránsito están asociados confactores de comportamiento, seguridad de los vehículos y la precariedad del espacio urbano.Reducir el número de accidentes de tránsito es un reto para los gestores deárea. La educación en el tránsito debe considerar la vigilancia como una estrategia eficaz para cambiar el comportamiento del conductor,principalmente en relación con el exceso de velocidad y el consumo de alcohol asociado con la conducción.La ingeniería tiene un papel importante para promover un entorno seguro,en el que la convivencia de peatones, ciclistas y conductores sea posible. El escenario en que se configura los accidentes de tránsito muestra la necesidad de los profesionales de la salud reconsiderar sus prácticas con el fin de replantear la imagen de la víctima de accidentes, las formas de trabajo de prevención de accidentes, la educación en el tránsito de peatones y conductores, con el fin de promover la salud y la cultura de paz. Existe la necesidad de políticas de salud públicay estrategias que hacen posible acceso a las acciones tanto en el campo preventivo como en el campo de la rehabilitación.

Precautionary measures to prevent damage, as defined in the Atomic Energy Law

International Nuclear Information System (INIS)

Marburger, P.

1983-01-01

The requirement to take every 'precaution which is necessary in the light of existing scientific knowledge and technology to prevent damage' (section 7, sub-section (2), no. 3 Atomic Energy Act) is not restricted to conventional (preventive) measures but is to be understood as a duty to actively provide for appropriate protection from conceivable damage. Below the level of legally binding laws and regulations, there is the level of scientific-technical codes and standards, which are of great significance to the licensing procedure under atomic energy law. As these codes and standards do not form part of the law but nevertheless represent the essence of scientific knowledge needed to fulfill the duty defined by the law, they are gaining full impact only through the licensing procedure, thus being transformed into concrete legal requirements. Hence one can say that the legal situation in atomic energy law relating to the licensing requirements as laid down in section 7, sub-section (2), no. 3 is presently characterised by a regulatory deficit. This regulatory deficit cannot be overcome by the means and tools offered by the current law. One possibility to fill the gap is to give a legally binding status to the safety guides defined by the deterministic safety concept, by listing the conceivable accidents to be mastered. This recommendable procedure could lead to an ordinance on the safety of nuclear installations. Such an ordinance could be kept abreast with technical progress and scientific knowledge by creating a referring legal instrument, pointing to, e.g., the KTA Safety Guide. (orig./HSCH) [de

Development of a Relationship Between Residual Ultimate Longitudinal Strength Versus Grounding Damage Index Diagram For Container Ships

DEFF Research Database (Denmark)

Kim, Do Kyun; Kim, Han Byul; Zhang, Xiaoming

2012-01-01

Various accidents such as grounding, collision, fire, and explosion commonly occur on operating ships. The structural damage caused by such accidents is often accompanied by casualties and serious pollution. Therefore, an accidental risk- based approach that is in line with the goal-based standard...

Flavour from accidental symmetries

International Nuclear Information System (INIS)

Ferretti, Luca; King, Stephen F.; Romanino, Andrea

2006-01-01

We consider a new approach to fermion masses and mixings in which no special 'horizontal' dynamics is invoked to account for the hierarchical pattern of charged fermion masses and for the peculiar features of neutrino masses. The hierarchy follows from the vertical, family-independent structure of the model, in particular from the breaking pattern of the Pati-Salam group. The lightness of the first two fermion families can be related to two family symmetries emerging in this context as accidental symmetries

Venous damage prevention by defibrotide in vinorelbine-treated patients.

Science.gov (United States)

Mare, M; Maisano, R; Caristi, N; Adamo, V; Altavilla, G; Carboni, R; Munaò, S; La Torre, F

2003-09-01

The aim of our study was to evaluate the incidence of venous toxicity induced by vinorelbine administration in patients who received a preventive therapy with defibrotide. From July 1996 to July 2002 we treated 203 patients with vinorelbine, 51 with vinorelbine alone and 152 with vinorelbine in combination with other drugs via peripheral vein infusion. Of the 203 patients, 123 were male and 80 female with a median age of 67 years (range 18 to 82 years), and 118 were chemotherapy-naive. Defibrotide was delivered i.v. at a dose of 400 mg in 250 ml normal saline. After infusion of 125 ml over about 15 min, vinorelbine mixed with 10 ml normal saline was delivered as quick brief repeated pulses over 5 min through the plastic tube, followed by infusion of the remaining defibrotide. The specific Rittenberg scale was used to assess venous irritation episodes. Among a total of 1336 vinorelbine infusions, with a median of five infusions per patient, the incidence of venous irritation episodes graded according to Rittenberg scale was 1.1% (15), of which 0.6% (8) were grade 2 and 0.5% (7) grade 1. Globally, 15 patients (7.3%) developed venous toxicity after a median of 3 infusions (range 1-14), but no patient had more than one event. Our findings support the use of defibrotide as an effective, safe and low-cost means for preventing vinorelbine-related venous damage.

Experimental studies on local damage of reinforced concrete structures by the impact of deformable missiles-Part 1

International Nuclear Information System (INIS)

Muto, K.; Tachikawa, H.; Sugano, T.; Tsubota, H.; Kobayshi, H.; Kasai, Y.; Koshika, N.; Tsujimoto, T.

1989-01-01

Structural damage induced by an accidental aircraft crash into a reinforced concrete structure includes local damage caused by the engine, the rigid portion of the aircraft, and the global elasto-plastic structural response caused by the entire aircraft. Local damage consists of spalling of concrete from the front face of the target together with missile penetration into the target, scabbing of concrete from the rear face of the target and perforation of the missile through the target. The engine is a soft missile that deforms during impact. An experimental research program has been planned and executed to establish a rational evaluation method of the local damage by the deformable engine missiles

Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study.

Science.gov (United States)

Vogel, Jody; Heard, Kennon J; Carlson, Catherine; Lange, Chad; Mitchell, Garrett

2011-11-01

Patients frequent take acetaminophen to treat dental pain. One previous study found a high rate of overuse of nonprescription analgesics in an emergency dental clinic. The purpose of this study is to determine if patients with dental pain are more likely to be treated for accidental acetaminophen poisoning than patients with other types of pain. We conducted a case-control study at 2 urban hospitals. Cases were identified by chart review of patients who required treatment for accidental acetaminophen poisoning. Controls were self-reported acetaminophen users taking therapeutic doses identified during a survey of emergency department patients. For our primary analysis, the reason for taking acetaminophen was categorized as dental pain or not dental pain. Our primary outcome was the odds ratio of accidental overdose to therapeutic users after adjustment for age, sex, alcoholism, and use of combination products using logistic regression. We identified 73 cases of accidental acetaminophen poisoning and 201 therapeutic users. Fourteen accidental overdose patients and 4 therapeutic users reported using acetaminophen for dental pain. The adjusted odds ratio for accidental overdose due to dental pain compared with other reasons for use was 12.8 (95% confidence interval, 4.2-47.6). We found that patients with dental pain are at increased risk to accidentally overdose on acetaminophen compared with patients taking acetaminophen for other reasons. Emergency physicians should carefully question patients with dental pain about overuse of analgesics. Copyright © 2011 Elsevier Inc. All rights reserved.

IAEA Regional Workshop on Development and Validation of EOP/AMG for Effective Prevention/Mitigation of Severe Core Damage

International Nuclear Information System (INIS)

1999-01-01

Materials of the IAEA Regional Workshop contain 24 presented lectures. Authors deal with development and validation of emergency operating procedures as well as with accident management guidelines (EOP/AMG) for effective prevention and mitigation of severe core damage

Accidentes de trabajo en un hospital de agudos

Directory of Open Access Journals (Sweden)

Pérez Bermúdez B.

1998-01-01

Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

Assessment of accidental refinery wastewater discharge: a case study

Energy Technology Data Exchange (ETDEWEB)

Bandyopadhyay, Amitava [University of Calcutta, Department of Chemical Engineering, Kolkata (India)

2011-04-15

The physicochemical qualities of an accidental discharge of refinery liquid waste, water, and soil sediment of that effluent-receiving water body (canal) were investigated. Analyses of the discharge, qualities of water, and sediment of the canal showed high parametric concentrations. Investigations revealed that the discharge took place form the spent caustic that was generated from the caustic wash tower of Fluidized Catalytic Cracker of the refinery. A simple but realistic model was suggested for the remediation of sediments of the canal with an estimated cost of about US $1.86 million. Recommendations were made to prevent such discharges and to revise thoroughly the Indian effluent discharge standards in force for petroleum oil refinery. Subsequently, revised standards were notified under Indian guidelines. Interestingly, cyanide besides many other parameters was introduced into these standards. Furthermore, Volatile Organic Compound (VOC) was also stipulated as an emission parameter from the waste water treatment plants. Concentration- and mass-based standards thus promulgated were stricter than the existing standards. (orig.)

Dropped fuel damage prediction techniques and the DROPFU code

International Nuclear Information System (INIS)

Mottershead, K.J.; Beardsmore, D.W.; Money, G.

1995-01-01

During refuelling, and fuel handling, at UK Advanced Gas Cooled Reactor (AGR) stations it is recognised that the accidental dropping of fuel is a possibility. This can result in dropping individual fuel elements, a complete fuel stringer, or a whole assembly. The techniques for assessing potential damage have been developed over a number of years. This paper describes how damage prediction techniques have subsequently evolved to meet changing needs. These have been due to later fuel designs and the need to consider drops in facilities outside the reactor. The paper begins by briefly describing AGR fuel and possible dropped fuel scenarios. This is followed by a brief summary of the damage mechanisms and the assessment procedure as it was first developed. The paper then describes the additional test work carried out, followed by the detailed numerical modelling. Finally, the paper describes the extensions to the practical assessment methods. (author)

Night work, long work weeks, and risk of accidental injuries. A register-based study

DEFF Research Database (Denmark)

Larsen, Ann D; Hannerz, Harald; Møller, Simone V

2017-01-01

of the European Labour Force Survey from 1999-2013. The current study was based on 150 438 participants (53% men and 47% women). Data on accidental injuries were obtained at individual level from national health registers. We included all 20-59-year-old employees working ≥32 hours a week at the time...... of the interview. We used Poisson regression to estimate the relative rates (RR) of accidental injuries as a function of night work or long work weeks (>40 hours per week) adjusted for year of interview, sex, age, socioeconomic status (SES), industry, and weekly working hours or night work. Age, sex and SES were....... No associations were found between long work weeks (>40 hours) and accidental injuries. Conclusion: We found a modest increased risk of accidental injuries when reporting night work. No associations between long work weeks and risk of accidental injuries were observed. Age, sex and SES showed no trends when...

A FLUORESCENCE-BASED SCREENING ASSAY FOR DNA DAMAGE INDUCED BY GENOTOXIC INDUSTRIAL CHEMICALS

Science.gov (United States)

The possibility of deliberate or accidental release of toxic chemicals in industrial, commercial or residential settings has indicated a need for rapid, cost-effective and versatile monitoring methods to prevent exposures to humans and ecosystems. Because many toxic industrial c...

Compact fluorescent lamp phosphors in accidental radiation monitoring

International Nuclear Information System (INIS)

Murthy, K. V. R.; Pallavi, S. P.; Ghildiyal, R.; Parmar, M. C.; Patel, Y. S.; Ravi Kumar, V.; Sai Prasad, A. S.; Natarajan, V.; Page, A. G.

2006-01-01

The application of lamp phosphors for accidental dosimetry is a new concept. Since the materials used in fluorescent lamps are good photo luminescent materials, if one can either use the inherent defects present in the phosphor or add suitable modifiers to induce thermoluminescence (TL) in these phosphors, then the device (fluorescent lamp) can be used as an accidental dosemeter. In continuation of our search for a suitable phosphor material, which can serve both as an efficient lamp phosphor and as a good radiation monitoring device, detailed examination has been carried out on cerium and terbium-doped lanthanum phosphate material. A 90 Sr beta source with 50 mCi strength (1.85 GBq) was used as the irradiation source for TL studies. The TL response as a function of dose received was examined for all phosphors used and it was observed that the intensity of the TL peak vs. dose received was a linear function in the dose range 0.1-200 Gy in each case. Incidentally LaPO 4 :Ce,Tb is a component of the compact fluorescent lamp marketed recently as an energy bright light source. Besides having very good luminescence efficiency, good dosimetric properties of these phosphors render them useful for their use in accidental dosimetry also. (authors)

Stage-by-stage licensing procedure, prevention of damage, control by administrative courts. Some comments on the Wyhl judgment of the Federal Administrative Court

International Nuclear Information System (INIS)

Sellner, D.

1986-01-01

The author discusses the three main items of the Wyhl judgment of the Federal Administrative Court, of December 19, 1985 - 7C65/82, which are likely to set trends. The judgment clarifies the function of the socalled preliminary approval of the concept and its delimitation to the preliminary partial licence. According to the judgment, the first is a licensing requirement in substantial law. Precaution for preventing damage according to sec. 7, sub-sec (2) No. 3 Atomic Energy Act is regarded by the Court not as a prevention of hazards, but as the obligation to take every precaution to prevent damage, i.e. types of damage have to be taken into account that cannot be excluded to develop to a real hazard or potential risk. The problem of extent of control by the administrative courts is solved by the approach based on the legal functions of competence and responsibility that are to be drawn from the principle of division of power. (HSCH) [de

Cytogenetic damages induced in vivo in human lymphocytes by environmental chemicals or radiation

International Nuclear Information System (INIS)

Cebulska-Wasilewska, A.

1999-01-01

The importance of various environmental exposures has been evident in variation in cancer incidence and mortality. Benzene is considered to be a human carcinogen, is clastogenic to rodents and humans, and it affects the immune response. Workers in various industrial plants, are exposed to benzene and benzene related compounds as a result of various activities in which benzene is processed, generated or used. Major sources of environmental exposure to benzene related compounds, continue to be active and passive smoking, auto exhaust, and driving or riding in automobiles. Benzene is of a particular interest, not only because of its known toxicity, but also because this was to be the parent compound and a model for extensive programs of metabolism of a variety of aromatic chemicals. Ionizing radiation is an unavoidable physical agent that is presented in environment, and public opinion is well aware against radiation risk and strongly against it. The aim of the presentation was comparison between cytogenetic damages induced in vivo by environmental chemicals with those of radiation. Results from biomonitoring survey on genotoxicity in human blood cells of benzene and benzene related compounds were compared to damages detected in lymphocytes of persons who had been accidentally exposed to gamma radiation. In the groups, that had been occupationally or environmentally exposed to benzene related compound, total aberration frequencies, or percent of aberrant cells ranged between 0 - 0.16 aberrations/cell or 16% of aberrant cells respectively. A multivariate regression analysis confirmed: (i) a significant association between cytogenetic damage and exposure to benzene related compound, (ii) a possible association between cytogenetic damage and cancer, (iii) a significant influence of smoking habit. In 1996 few persons were suspected of accidental exposure to gamma radiation. To estimate the absorbed doses, lymphocytes from their blood have been analyzed for the presence of

36 CFR 223.113 - Modification of contracts to prevent environmental damage or to conform to forest plans.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Modification of contracts to prevent environmental damage or to conform to forest plans. 223.113 Section 223.113 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM...

In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids.

Science.gov (United States)

Peng, Sui; Huo, Xiaofang; Rezaei, Davood; Zhang, Qiuyang; Zhang, Xi; Yu, Chunhua; Asanuma, Kiyotaka; Cheng, Edaire; Pham, Thai H; Wang, David H; Chen, Minhu; Souza, Rhonda F; Spechler, Stuart Jon

2014-07-15

Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects against DCA-induced injury in vivo in patients and in vitro using nonneoplastic, telomerase-immortalized Barrett's cell lines. We took biopsies of Barrett's esophagus from 21 patients before and after esophageal perfusion with DCA (250 μM) at baseline and after 8 wk of oral UDCA treatment. DNA damage was assessed by phospho-H2AX expression, neutral CometAssay, and phospho-H2AX nuclear foci formation. Quantitative PCR was performed for antioxidants including catalase and GPX1. Nrf2, catalase, and GPX1 were knocked down with siRNAs. Reporter assays were performed using a plasmid construct containing antioxidant responsive element. In patients, baseline esophageal perfusion with DCA significantly increased phospho-H2AX and phospho-p65 in Barrett's metaplasia. Oral UDCA increased GPX1 and catalase levels in Barrett's metaplasia and prevented DCA perfusion from inducing DNA damage and NF-κB activation. In cells, DCA-induced DNA damage and NF-κB activation was prevented by 24-h pretreatment with UDCA, but not by mixing UDCA with DCA. UDCA activated Nrf2 signaling to increase GPX1 and catalase expression, and protective effects of UDCA pretreatment were blocked by siRNA knockdown of these antioxidants. UDCA increases expression of antioxidants that prevent toxic bile acids from causing DNA damage and NF-κB activation in Barrett's metaplasia. Elucidation of this molecular pathway for UDCA protection provides rationale for clinical trials on UDCA for chemoprevention in Barrett's esophagus. Copyright © 2014 the American Physiological Society.

Chronic or accidental exposure of oysters to norovirus: is there any difference in contamination?

Science.gov (United States)

Ventrone, Iole; Schaeffer, Julien; Ollivier, Joanna; Parnaudeau, Sylvain; Pepe, Tiziana; Le Pendu, Jacques; Le Guyader, Françoise S

2013-03-01

Bivalve molluscan shellfish such as oysters may be contaminated by human pathogens. Currently, the primary pathogens associated with shellfish-related outbreaks are noroviruses. This study was conducted to improve understanding of oyster bioaccumulation when oysters were exposed to daily contamination or one accidental contamination event, i.e., different modes of contamination. Oysters were contaminated with two representative strains of norovirus (GI.1 and GII.3) and then analyzed with real-time reverse transcription PCR. Exposure to a repeated virus dose for 9 days (mimicking a growing area subjected to frequent sewage contamination) led to an additive accumulation that was not significantly different from that obtained when the same total dose of virus was added all at once (as may happen after accidental sewage discharge). Similarly, bioaccumulation tests performed with mixed strains revealed additive accumulation of both viruses. Depuration may not be efficient for eliminating viruses; therefore, to prevent contaminated shellfish from being put onto the market, continuous sanitary monitoring must be considered. All climatic events or sewage failures occurring in production areas must be recorded, because repeated low-dose exposure or abrupt events may lead to similar levels of accumulation. This study contributes to an understanding of norovirus accumulation in oysters and provides suggestions for risk management strategies.

Involving Parents in Indicated Early Intervention for Childhood PTSD Following Accidental Injury

Science.gov (United States)

Cobham, Vanessa E.; March, Sonja; De Young, Alexandra; Leeson, Fiona; Nixon, Reginald; McDermott, Brett; Kenardy, Justin

2012-01-01

Accidental injuries represent the most common type of traumatic event to which a youth is likely to be exposed. While the majority of youth who experience an accidental injury will recover spontaneously, a significant proportion will go on to develop Post-Traumatic Stress Disorder (PTSD). And yet, there is little published treatment outcome…

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage.

Science.gov (United States)

Shan, Chao; Muruato, Antonio E; Jagger, Brett W; Richner, Justin; Nunes, Bruno T D; Medeiros, Daniele B A; Xie, Xuping; Nunes, Jannyce G C; Morabito, Kaitlyn M; Kong, Wing-Pui; Pierson, Theodore C; Barrett, Alan D; Weaver, Scott C; Rossi, Shannan L; Vasconcelos, Pedro F C; Graham, Barney S; Diamond, Michael S; Shi, Pei-Yong

2017-09-22

Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.

Science.gov (United States)

Hammes, Hans-Peter; Du, Xueliang; Edelstein, Diane; Taguchi, Tetsuya; Matsumura, Takeshi; Ju, Qida; Lin, Jihong; Bierhaus, Angelika; Nawroth, Peter; Hannak, Dieter; Neumaier, Michael; Bergfeld, Regine; Giardino, Ida; Brownlee, Michael

2003-03-01

Three of the major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage (the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway) are activated by increased availability of the glycolytic metabolites glyceraldehyde-3-phosphate and fructose-6-phosphate. We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and NF-kappaB activation by activating transketolase, and also prevented experimental diabetic retinopathy. The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications.

Medical management of accidentally exposed individuals

International Nuclear Information System (INIS)

Nenot, J.C.

1998-01-01

Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Whilst transfusion and bone marrow transplantation have been used with some success starting with the first treatments of accident victims, other therapeutic strategies are needed. With the development of experimental and clinical haematology, promising new approaches to the treatment of aplasia have appeared. New trends for the treatment of haemopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. Haemopoietic growth factors stimulate the proliferation and/or differentiation of haemopoietic progenitors and, possibly, stem cells. Furthermore, they act on the functions of mature cells. Currently, they have specific uses in haematology related to their role in the regulation of growth and in the differentiation of haemopoietic progenitor cells. Growth factors have already been used for the treatment of accidental radiation induced aplasia and lessons have been learned from their medical management and followup. (author)

Medical management of accidentally exposed individuals

Energy Technology Data Exchange (ETDEWEB)

Nenot, Jean-Claude [CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

1997-12-31

Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Although both transfusion and bone marrow transplantation have been used with some success since the first treatments of patients, other therapeutic strategies are needed. New promising approaches of the treatment of aplasia have appeared with the development of experimental and clinical hematology. Some new trends for the treatment of the hematopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. The hematopoietic growth factors stimulate proliferation and/or differentiation of hematopoietic progenitors and possibly stem cells. Furthermore, they act on the functions of mature cells. They have now specific uses in hematology, related to their role in the regulation of growth and differentiation of hematopoietic progenitor cells. Some growth factors have already been used for the treatment of accidental radiation-induced aplasia and lessons have been learned from their medical management and follow-up. (author) 30 refs.

Accidentes en la infancia: una problemática actual en pediatría Accidents in the childhood: a current problem in pediatrics

Directory of Open Access Journals (Sweden)

Migdalia Torres Márquez

Full Text Available Las lesiones accidentales constituyen una de las principales causas de amenaza para la vida en la población infantil, por lo cual la prevención de accidentes puede considerarse una emergencia sanitaria y social, tanto por la elevada mortalidad, morbilidad y discapacidad que estos ocasionan como por el elevado costo económico que representan; por tal razón, en el presente estudio se revisó la bibliografía especializada sobre algunos aspectos de interés, tales como: factores de riesgo, causas más frecuentes, condiciones favorecedoras y algunas medidas para prevenirlos, teniendo en cuenta que padres y educadores desempeñan una función primordial en esta tarea.Accidental injuries constitute one of the main life-threatening causes in children population, therefore the prevention of accidents can be considered a social and health emergency due to their high mortality, morbidity, inability and economic high cost. The present study reviewed the specialized literature cited on some interesting aspects, such as risk factors, most frequent causes, favorable conditions and some measures to prevent them, considering that parents and educators play an essential role in this task.

The United States should forego a damage-limitation capability against China

Science.gov (United States)

Glaser, Charles L.

2017-11-01

Bottom Lines • THE KEY STRATEGIC NUCLEAR CHOICE. Whether to attempt to preserve its damage-limitation capability against China is the key strategic nuclear choice facing the United States. The answer is much less clear-cut than when the United States faced the Soviet Union during the Cold War. • FEASIBILITY OF DAMAGE LIMITATION. Although technology has advanced significantly over the past three decades, future military competition between the U.S. and Chinese forces will favor large-scale nuclear retaliation over significant damage limitation. • BENEFITS AND RISKS OF A DAMAGE-LIMITATION CAPABILITY. The benefits provided by a modest damage-limitation capability would be small, because the United States can meet its most important regional deterrent requirements without one. In comparison, the risks, which include an increased probability of accidental and unauthorized Chinese attacks, as well as strained U.S.—China relations, would be large. • FOREGO DAMAGE LIMITATION. These twin findings—the poor prospects for prevailing in the military competition, and the small benefits and likely overall decrease in U.S. security—call for a U.S. policy that foregoes efforts to preserve or enhance its damage-limitation capability.

Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.

Science.gov (United States)

Nikula, P; Ruohola, H; Alhonen-Hongisto, L; Jänne, J

1985-06-01

We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem. Biophys. Res. Commun. 120, 9-14]. We have now investigated whether carnitine also influences the development of the well-known mitochondrial damage produced by the drug in L1210 leukaemia cells. Palmitate oxidation was distinctly inhibited in tumour cells exposed to 5 microM-methylglyoxal bis(guanylhydrazone) for only 7 h. Electron-microscopic examination of the drug-exposed cells revealed that more than half of the mitochondria were severely damaged. Similar exposure of the leukaemia cells to the drug in the presence of carnitine not only abolished the inhibition of fatty acid oxidation but almost completely prevented the drug-induced mitochondrial damage. The protection provided by carnitine appeared to depend on the intracellular concentration of methylglyoxal bis(guanylhydrazone), since the mitochondria-sparing effect disappeared at higher drug concentrations.

Accidental injuries and cutaneous contaminations during general ...

African Journals Online (AJOL)

Conclusion: This study has demonstrated that cutaneous, percutaneous, and mucous membrane exposure to patients blood and body fluids are common events during general surgical operations. Most accidental injuries were due to solid suture needle-sticks, mostly injured personnel were the primary operating surgeons, ...

Modulation of radio-induced oxidative damage by the combination of pentoxifylline and γ-tocopherol in skin fibroblasts and microvascular endothelial cells

International Nuclear Information System (INIS)

Laurent, Carine; Roy, Laurence; Voisin, Philippe; Pouget, JeanPierre

2004-01-01

Clinical or accidental localized ionizing radiation exposure can induce severe skin damage constituting the cutaneous radiological syndrome which is divided in acute and late phases. The combination of pentoxifylline (PTX), antioxidant phytochemical, and γ-tocopherol, antioxidant nutrient shows effectiveness in reducing the late radio-induced skin damage with a long period. This work aims to investigate the molecular and cellular mechanisms involved in the effects of this combination

On the accuracy, uniqueness and implication of dimensionless accidental relations between fundamental constants

International Nuclear Information System (INIS)

Bahran, M.; Univ. of Oklahoma, Norman-OK,

2002-01-01

Ibrahim et al(1) found an accidental formula relating the gravitational coupling constant, the electromagnetic fine structure constant and the proton to electron mass ratio. This work comments on such relation, in particular it studies the accuracy, uniqueness and unification implication of such accidental relation.(author)

Measures to prevent concrete damage due to alkali-silica reaction in the Netherlands: Current state-of-affairs

NARCIS (Netherlands)

Heijnen, W.M.M.; Larbi, J.A.

1999-01-01

In CUR-Recommendation 38, various vital measures that need to be taken during design of new concrete-mixtures in order to prevent damage due to ASR in the concrete have been outlined. The most important of these measures are: • the use of blast furnace slag cement (with a high slag content: 50 % by

The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.

Science.gov (United States)

Amaral, Nuno; Vendrell, Alexandre; Funaya, Charlotta; Idrissi, Fatima-Zahra; Maier, Michael; Kumar, Arun; Neurohr, Gabriel; Colomina, Neus; Torres-Rosell, Jordi; Geli, María-Isabel; Mendoza, Manuel

2016-05-01

Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response to chromosome segregation defects in yeast and animal cells. How chromatin bridges are detected, and whether abscission inhibition prevents their damage, remain key unresolved questions. We find that bridges induced by DNA replication stress and by condensation or decatenation defects, but not dicentric chromosomes, delay abscission in a NoCut-dependent manner. Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B. NoCut does not prevent DNA damage following condensin or topoisomerase II inactivation; however, it protects anaphase bridges and promotes cellular viability after replication stress. Therefore, the molecular origin of chromatin bridges is critical for activation of NoCut, which plays a key role in the maintenance of genome stability after replicative stress.

Youth Versus Adult “Weightlifting” Injuries Presenting to United States Emergency Rooms: Accidental Versus Nonaccidental Injury Mechanisms

Science.gov (United States)

Myer, Gregory D.; Quatman, Carmen E.; Khoury, Jane; Wall, Eric J.; Hewett, Timothy E.

2014-01-01

Myer, GD, Quatman, CE, Khoury, J, Wall, EJ, and Hewett, TE. Youth versus adult “weightlifting” injuries presenting to united states emergency rooms: accidental versus nonaccidental injury mechanisms. J Strength Cond Res 23(7): 2054–2060, 2009—Resistance training has previously been purported to be unsafe and ineffective in children. The purpose of this investigation was to evaluate resistance training-related injuries presenting to U.S. emergency rooms by age, type, and mechanism of injury. We hypothesized that older athletes would sustain greater percentages of joint sprains and muscle strains, whereas younger athletes would sustain a greater percentage of accidental injuries that would result in an increased percentage of fractures in youths. The U.S. Consumer Product Safety Commission (CPSC) National Electronic Injury Surveillance System was queried from 2002 to 2005 using the CPSC code for “Weightlifting.” Subjects between the ages of 8 and 30 were grouped by age categories 8 to 13 (elementary/middle school age), 14 to 18 (high school), 19 to 22 (college), and 23 to 30 (adult). Injuries were classified as “accidental” if caused by dropped weight or improper equipment use. Multiple logistic regression was used to compare accidental injuries between age groups. The sample consisted of 4, 111 patients. Accidental injuries decreased (p 14 to 18 > 19 to 22 years = 23 to 30 years. Conversely, sprain/strain injuries increased in each successive age group (p injuries (n = 2, 565) showed that the oldest categories (19–22 and 23–30 yr) demonstrated a greater percentage of sprains and strains relative to younger age categories (p injuries sustained in the 8 to 13 group were to the hand and foot and were most often related to “dropping” and “pinching” in the injury descriptions, and there was an increased percentage of fractures in the 8 to 13 group relative to all other groups (p injuries are the result of accidents that are potentially

Accidental sulphuric acid poisoning in a newborn | Abdulkadir ...

African Journals Online (AJOL)

Accidental sulphuric acid poisoning in a newborn. I Abdulkadir, L Hassan, F Abdullahi, FD Akeredolu, S Purdue, M Okpe, AM Sobowale, OA Adewumi, U Abdullahi, MA Onadiran, TT Sholadoye, S Baba, WN Ogala ...

Cytogenetic biological dosimetry. Dose estimative in accidental exposure

International Nuclear Information System (INIS)

Santos, O.R. dos; Campos, I.M.A. de.

1988-01-01

The methodology of cytogenetic biological dosimetry is studied. The application in estimation of dose in five cases of accidental exposure is reported. An hematological study and culture of lymphocytes is presented. (M.A.C.) [pt

Transient analyses on the cooling channels of the DEMO HCPB blanket concept under accidental conditions

International Nuclear Information System (INIS)

Chen, Yuming; Ghidersa, Bradut-Eugen; Jin, Xue Zhou

2016-01-01

Highlights: • This paper presents transient CFD analyses on the cooling channels of the DEMO HCPB FW for accidental scenarios LOCA and LOFA. • In both LOCA & LOFA, the wall temperature increases quickly to an unacceptable level within seconds. • If the coolant flow rate is maintained at a half of nominal value in case of LOFA (partial LOFA), the wall temperature rises much slower, but will still leads to a damage of structure within minutes. • The simulated heat transfer coefficients were compared with empirical correlations. - Abstract: Helium Cooled Pebble Bed (HCPB) blanket concept is one of the DEMO (Demonstration Power Plant) blanket concepts running for the final DEMO design selection. In this paper, transient analyses on the cooling channels of the FW are carried out by means of CFD simulations for the selected accidental scenarios loss-of-coolant-accident (LOCA) and loss-of-flow-accident (LOFA). ANSYS-CFX is used for the simulations. The simulation results help to understand how fast the temperature of the FW can increase and what is the time window that is available until the temperature of the structural material reaches the design limit in order to be able to define a suitable protection strategy for the system. In view of later developments of the models, the heat transfer coefficients calculated with CFD are compared with the values predicted by two widely used correlations for turbulent pipe flows.

Transient analyses on the cooling channels of the DEMO HCPB blanket concept under accidental conditions

Energy Technology Data Exchange (ETDEWEB)

Chen, Yuming, E-mail: Yuming.chen@kit.edu; Ghidersa, Bradut-Eugen; Jin, Xue Zhou

2016-11-01

Highlights: • This paper presents transient CFD analyses on the cooling channels of the DEMO HCPB FW for accidental scenarios LOCA and LOFA. • In both LOCA & LOFA, the wall temperature increases quickly to an unacceptable level within seconds. • If the coolant flow rate is maintained at a half of nominal value in case of LOFA (partial LOFA), the wall temperature rises much slower, but will still leads to a damage of structure within minutes. • The simulated heat transfer coefficients were compared with empirical correlations. - Abstract: Helium Cooled Pebble Bed (HCPB) blanket concept is one of the DEMO (Demonstration Power Plant) blanket concepts running for the final DEMO design selection. In this paper, transient analyses on the cooling channels of the FW are carried out by means of CFD simulations for the selected accidental scenarios loss-of-coolant-accident (LOCA) and loss-of-flow-accident (LOFA). ANSYS-CFX is used for the simulations. The simulation results help to understand how fast the temperature of the FW can increase and what is the time window that is available until the temperature of the structural material reaches the design limit in order to be able to define a suitable protection strategy for the system. In view of later developments of the models, the heat transfer coefficients calculated with CFD are compared with the values predicted by two widely used correlations for turbulent pipe flows.

Accidental nuclear excursion recuplex operation 234-5 facility: Final medical report

Energy Technology Data Exchange (ETDEWEB)

Fuqua, P. A.

1962-04-07

The April 7, 1962 criticality accident involving human exposures was the first to have occurred in any production facility at Hanford. The accidental nuclear excursion did not result in any mechanical damage or spread of contamination. Three employees received over-exposure to gamma and neutron radiation. None were fatally exposed and in each case the over-exposure was recognized promptly. Following an initial period of medical observation and testing, the men were released to work. They continued to be followed clinically. Clinical studies performed were hematological procedures including leukocyte chromosome aberrations, morphologically aberrant blood cells, bone marrow evaluations, blood chemistry determinations, amino acid excretion studies, seminal fluid, urinary gonadotropins and estrogen excretion studies, testicular biopsies and crystalline lens examinations. These studies, along with a brief description of the accident and of the dosimetry, are summarized in this report by those participating in the studies. In view of the dose ranges received in these cases, both the negative and positive findings are considered to be of unusual interest due to the lack of knowledge of effects following human exposures at these levels.

Neuroimaging for non-accidental head injury in childhood: A proposed protocol

International Nuclear Information System (INIS)

Jaspan, T.; Griffiths, P.D.; McConachie, N.S.; Punt, J.A.G.

2003-01-01

Non-accidental head injury (NAHI) is a major cause of neurological disability and death during infancy. Radiological imaging plays a crucial role in evaluating craniospinal injury, both for guiding medical management and the forensic aspects of abusive trauma. The damage sustained is varied, complex and may be accompanied by an evolving pattern of brain injury secondary to a cascade of metabolic and physiological derangements. Regrettably, many cases are poorly or incompletely evaluated leading to diagnostic errors and difficulties in executing subsequent child care or criminal proceedings. It is evident, from cases referred to the authors, that imaging protocols for NAHI are lacking (or only loosely adhered to, if present) in many centres throughout the U.K. Future research in this field will also be hampered if there is a lack of consistent and reliable radiological data. There is no nationally agreed protocol for imaging NAHI. We propose such a protocol, based upon a wide experience in the medical management of child abuse and extensive involvement in the medicolegal aspects of NAHI. Jaspan, T., et al. (2003). Clinical Radiology58, 44--53

Neuroimaging for non-accidental head injury in childhood: A proposed protocol

Energy Technology Data Exchange (ETDEWEB)

Jaspan, T.; Griffiths, P.D.; McConachie, N.S.; Punt, J.A.G

2003-01-01

Non-accidental head injury (NAHI) is a major cause of neurological disability and death during infancy. Radiological imaging plays a crucial role in evaluating craniospinal injury, both for guiding medical management and the forensic aspects of abusive trauma. The damage sustained is varied, complex and may be accompanied by an evolving pattern of brain injury secondary to a cascade of metabolic and physiological derangements. Regrettably, many cases are poorly or incompletely evaluated leading to diagnostic errors and difficulties in executing subsequent child care or criminal proceedings. It is evident, from cases referred to the authors, that imaging protocols for NAHI are lacking (or only loosely adhered to, if present) in many centres throughout the U.K. Future research in this field will also be hampered if there is a lack of consistent and reliable radiological data. There is no nationally agreed protocol for imaging NAHI. We propose such a protocol, based upon a wide experience in the medical management of child abuse and extensive involvement in the medicolegal aspects of NAHI. Jaspan, T., et al. (2003). Clinical Radiology58, 44--53.

Measuring the visual salience of alignments by their non-accidentalness.

Science.gov (United States)

Blusseau, S; Carboni, A; Maiche, A; Morel, J M; Grompone von Gioi, R

2016-09-01

Quantitative approaches are part of the understanding of contour integration and the Gestalt law of good continuation. The present study introduces a new quantitative approach based on the a contrario theory, which formalizes the non-accidentalness principle for good continuation. This model yields an ideal observer algorithm, able to detect non-accidental alignments in Gabor patterns. More precisely, this parameterless algorithm associates with each candidate percept a measure, the Number of False Alarms (NFA), quantifying its degree of masking. To evaluate the approach, we compared this ideal observer with the human attentive performance on three experiments of straight contours detection in arrays of Gabor patches. The experiments showed a strong correlation between the detectability of the target stimuli and their degree of non-accidentalness, as measured by our model. What is more, the algorithm's detection curves were very similar to the ones of human subjects. This fact seems to validate our proposed measurement method as a convenient way to predict the visibility of alignments. This framework could be generalized to other Gestalts. Copyright © 2015 Elsevier Ltd. All rights reserved.

Personal protective clothing against accidental immersion

Energy Technology Data Exchange (ETDEWEB)

Elliott, David; Tipton, Michael [Surrey Univ., Robens Inst. of Health and Safety, Guildford (United Kingdom)

1997-12-31

The requirements for protective clothing against accidental immersion are discussed and the advantages and limitations of the main types of immersion protection available are analysed. The variety of designs available reflects the various circumstances under which they may be used. In broad terms in the offshore industry these include the following activities: normal work without risk of immersion but with a possible need to abandon the rig or ship; work in areas where there is risk of accidentally falling into the sea; flying over the sea in a helicopter. The first response to sudden immersion in sea water, which must usually be considered to be cold, is a sudden gasp often followed by an immediate phase of uncontrolled breathing. Since control of ones breathing between and under the breaking waves is essential to staying alive, this is a critical time. After surviving this initial ``cold shock`` phase, the effects of body heat loss become hazardous. Protection against hypothermia has been the priority for those providing survival suits and protective clothing while the hazard of the immediate response to cold immersion has been unrecognised to a large extent. (UK)

Preventive measures against concrete damage to ASR in the Netherlands current state-of-affairs

OpenAIRE

Heijnen, W.M.M.; Larbi, J.A.

1999-01-01

In CUR-Recommendation 38, various vital measures that need to be taken during design of new concrete-mixtures in order to prevent damage due to ASR in the concrete have been outlined. The most important of these measures are: - the use of blast furnace slag cement (with a high slag content: ≥50% by mass of cement as slag); - or the use of portland fly ash cement (containing at least 25% by mass of cement as fly ash). If one of these cement types is used, then the potential reactivity of the a...

Fatores contribuintes aos acidentes aeronáuticos Factores contribuyentes de accidentes aeronáuticos Contributive factors to aviation accidents

Directory of Open Access Journals (Sweden)

Marcia Fajer

2011-04-01

Full Text Available O objetivo do estudo foi comparar os resultados de investigações de acidentes aeronáuticos brasileiros do Centro de Investigação e Prevenção de Acidentes Aeronáuticos (Cenipa com os do sistema de análise e classificação de fatores humanos (Human Factors Analysis and Classification System - HFACS. Foram analisados e comparados os relatórios finais de 36 investigações de acidentes aeronáuticos ocorridos entre 2000 e 2005, no estado de São Paulo. Foram mencionados 163 fatores contribuintes dos acidentes aeronáuticos nos relatórios do Cenipa, enquanto 370 foram identificados por meio do HFACS. Conclui-se que as análises do Cenipa não contemplaram fatores organizacionais associados aos acidentes aéreos.El objetivo del estudio fue comparar los resultados de investigaciones de accidentes aeronáuticos brasileños del Centro de Investigación y Prevención de Accidentes Aeronáuticos (CENIPA con los del sistema de análisis y clasificación de factores humanos (Human Factors Analysis and Classification System - HFACS. Se analizaron y compararon los informes finales de 36 investigaciones de accidentes aeronáuticos ocurridos entre 2000 y 2005, en el estado de Sao Paulo, Sureste de Brasil. Se mencionaron 163 factores contribuyentes de accidentes aeronáuticos en los informes del CENIPA, mientras que 370 fueron identificados por medio del HFACS. Se concluye que los análisis del CENIPA no contemplaron factores organizacionales asociados con los accidentes aéreos.The objective of the study was to compare the results of aviation accident analyses performed by the Center for Investigation and Prevention of Aviation Accidents (CENIPA with the method Human Factors Analysis and Classification System (HFACS. The final reports of thirty-six general aviation accidents occurring between 2000 and 2005 in the State of São Paulo, Southeastern Brazil were analyzed and compared. CENIPA reports mentioned 163 contributive factors, while HFACS

Risk assessment for stonecutting enterprises Accidental risks in the course of petroleum production and stone extraction

Science.gov (United States)

Aleksandrova, A. J.; Timofeeva, S. S.

2018-01-01

The paper is devoted to the assessment of accidental risks occurring at the works engaged in stone extracting and petroleum production. Two basic kinds of accidents common for stone extracting and petroleum production have been chosen to be discussed in the part under consideration. The most dangerous accidental situation characteristic for a stone milling line is an unsanctioned explosion, UE, of blasting agents used for the development of stone deposits. The analysis of a risk occurrence in certain accidental situations is to be carried out. With reference to petroleum extraction, a combustibles and lubricants (C & L) explosion is the most dangerous of characteristic accidental situations. To reveal the most probable causes of accidental situations to be realized, a graph of cause and effect relations has been constructed for each of the accidental situations most probable causes to real situation of an accident. Disasters of a natural origin are the most probable causes of unsanctioned explosions at the deposits of stone raw materials. Technology related natural disasters are the most probable causes of unsanctioned explosions to be realized at multiple well platforms engaged in petroleum production.

Dynamic Analysis of Cable-Stayed Bridges Affected by Accidental Failure Mechanisms under Moving Loads

Directory of Open Access Journals (Sweden)

Fabrizio Greco

2013-01-01

Full Text Available The dynamic behavior of cable-stayed bridges subjected to moving loads and affected by an accidental failure in the cable suspension system is investigated. The main aim of the paper is to quantify, numerically, the dynamic amplification factors of typical kinematic and stress design variables, by means of a parametric study developed in terms of the structural characteristics of the bridge components. The bridge formulation is developed by using a geometric nonlinear formulation, in which the effects of local vibrations of the stays and of large displacements in the girder and the pylons are taken into account. Explicit time dependent damage laws, reproducing the failure mechanism in the cable system, are considered to investigate the influence of the failure mode characteristics on the dynamic bridge behavior. The analysis focuses attention on the influence of the inertial characteristics of the moving loads, by accounting coupling effects arising from the interaction between girder and moving system. Sensitivity analyses of typical design bridge variables are proposed. In particular, the effects produced by the moving system characteristics, the tower typologies, and the failure mode characteristics involved in the cable system are investigated by means of comparisons between damaged and undamaged bridge configurations.

Accidental poisoning with detomidine and butorphanol.

Science.gov (United States)

Hannah, N

2010-09-01

This is a case report concerning a veterinarian who spilled detomidine and butorphanol on dermatitic hands while sedating a horse. This resulted in acute poisoning from which the patient spontaneously recovered with supportive management. Veterinarians often suffer from occupational dermatitis and handle strong sedatives with no gloves while working around unpredictable animals. Thus, this group is at risk of accidental self-poisoning from this method.

accidental injuries in children (physical child abuse)

African Journals Online (AJOL)

2016-12-06

Dec 6, 2016 ... are often due to minor accidental injuries. However ... In dark-skinned children, bruises may be confused with café-au-lait spots. .... A bruise should not be examined in isolation if reason- ... dren with intellectual disability, such as autism and hy- ... opmental stage, social and environmental factors includ-.

21 CFR 1002.20 - Reporting of accidental radiation occurrences.

Science.gov (United States)

2010-04-01

...: Accidental Radiation Occurrence Reports (HFZ-240), Office of Communication, Education, and Radiation Programs, 9200 Corporate Blvd., Rockville, MD 20850, and the reports and their envelopes shall be distinctly...

Propagation of cracks and damage in non aging linear viscoelastic media

International Nuclear Information System (INIS)

Nguyen, S.T.

2010-01-01

Most of France's energy is nuclear. The reactor building comprises a internal and external containment. The internal containment is prestressed to limit the flow of leakage in the internal-external space. The prestress decreases during time by the creep of concrete. It may propagate the cracks by the accidental internal pressure. So we define two research problems: propagation of macro-cracks in viscoelastic structure; effective behavior of micro-cracked viscoelastic material. Firstly, we develop a Burger viscoelastic model of concrete with two approaches: numerical and analytical. Then we solve the problem of single cracks in developing thermodynamically the concept of energy release rate. In the third part we develop a viscoelastic model to study the effective behavior of micro-cracked materials in the case without propagation. The problem of propagation of microcracks is then studied by a numerical approach based on the 'representative pattern morphology'. These studies are finally applied to solve the problems of crack propagation and damage of containment under accidental internal pressure. (authors)

Mortalidad por accidentes de tránsito en Bayamo, Cuba 2011

Directory of Open Access Journals (Sweden)

Arlines Piña-Tornés

Full Text Available Con el objetivo de describir la mortalidad por accidentes de tránsito en Bayamo, Cuba, en el año 2011 se realizó una revisión de los pacientes lesionados y fallecidos a causa de accidentes de tránsito, registrados en Hospital Carlos M. de Céspedes. Se atendieron en emergencias 1365 lesionados, predominando el grupo etario de 25 a 44 años con 372 pacientes (27,3%, y el sexo masculino con 1071 (78,5%. Fallecieron 46 personas, en su mayoría del mismo grupo de edad y de sexo masculino. Los traumatismos múltiples (52,6% y cráneofaciales (34,2% fueron las localizaciones predominantes. Se destacaron los atropellos por vehículo de motor con mortalidad del 26,3%. En conclusión, la mortalidad por accidentes de tránsito predomina en adultos jóvenes masculinos; cuyas consecuencias fatales son debido a traumatismos múltiples por atropellos.

Report of accidental CS ingestion among seven patients in central Israel and review of the current literature.

Science.gov (United States)

Solomon, I; Kochba, I; Eizenkraft, E; Maharshak, N

2003-10-01

A report of seven people who accidentally drank a juice contaminated with CS (o-chlorobenzylidene malononitrile) is given. Due to its mucosal irritating properties, CS (also known as "tear gas") is commonly used by policemen and soldiers in riot control. However, only a few reports of its ingestion by humans exist. Ingestion of CS may cause immediate irritation of the oral mucosa and gastrointestinal symptoms later on. Damage of internal organs, which has been shown in animals but only rarely in humans, is probably related to the dose ingested. The extensive use of CS gas merits recognition of the signs and symptoms of its exposure in order to reduce anxiety in both patients and medical staff and to facilitate fast and efficient management.

Mortalidad intrahospitalaria por accidente cerebrovascular

OpenAIRE

Federico Rodríguez Lucci; Virginia Pujol Lereis; Sebastián Ameriso; Guillermo Povedano; María F. Díaz; Alejandro Hlavnicka; Néstor A. Wainsztein; Sebastián F. Ameriso

2013-01-01

La mortalidad global por accidente cerebrovascular (ACV) ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Str...

Clinical study of lesions caused by accidental local exposure to ionizing radiations

International Nuclear Information System (INIS)

Menoux, A.M.

1977-01-01

During the last few years the radiopathology service of the Curie Foundation has admitted more than a hundred patients who were followed and treated for irradiation or suspected irradiation after a work accident. Accidents followed by clinical symptoms account for about half the cases examined. Some of these clinical signs were benign whereas others developed very seriously, all possible conditions between these two extremes being represented. This report neglects cases of high total exposure and deals only with those of partial irradiation where local symptoms predominate, usually at the distal extremities of the upper limbs and exceptionally at the root or distal extremity of the lower limbs. Six clinical cases were selected as particularly revealing and are discussed below: accidental exposure of both hands to an iridium-192 source; chronic exposure to X-rays (left hand and right lower half-lip); accidental exposure of the right hand and antero-external face of the right thigh to a iridium-192 source; acute accidental exposure of the left hand to X-rays emitted under 50 kV; accidental exposure of both hands to cobalt-60 radiation; radiolesions of the left lower limb following a critical power excursion (gamma rays and neutrons) [fr

Early recognition of damage and course of damage on metal components

International Nuclear Information System (INIS)

1992-01-01

In 1985, the German Research Association set up the programme 'Early recognition of damage and course of damage on metal components'. The concept worked out by a programme committee provided that scientifically secured bases for the understanding of the occurrence of damage, the prevention of damage, affecting damage, and the mechanism triggering damage, or cumulation of damage should be obtained. 36 individual projects costing 14 million DM were supported in the course of 6 years. The task of a test group was to find these projects from a far larger number of applications which promised an increase in knowledge in the sense of the target of the programme. For the final colloquium, the test group chose those contributions which had not previously been published to the wider technical public. (orig.) [de

Lessons learned from accidental exposures in radiotherapy

International Nuclear Information System (INIS)

2000-01-01

The medical use of radiation is unique in that patients are intentionally exposed to radiation. The aim in radiation therapy is twofold: to deliver a dose and dose distribution that is adequate for tumour control, but which also minimizes complications in normal tissues. In therapeutic applications, the doses are high and a deviation from the prescribed dose may have severe or even fatal consequences. There is therefore a great need to ensure adequate radiation protection and safety in radiotherapy by verifying that all personnel involved are appropriately trained for their duties, that the equipment used meets relevant international specifications for radiation safety and that safety culture is embedded in routine activities in radiotherapy departments. Many individuals must interact and work together on highly technical measurements and calculations, and therefore the potential for mistakes is great. A review of the mistakes shows that most are due to human error. The International Basic Safety Standards for Protection against Ionizing Radiation and the Safety of Radiation Sources (IAEA Safety Series No. 115) require that a prompt investigation be conducted whenever an accidental medical exposure of patients occurs. The report of the investigation is to be disseminated to the appropriate parties so that lessons can be learned to prevent similar accidents or mitigate their consequences in the future. This Safety Report is a collection of a large number of events that may serve as a checklist against which to test the vulnerability of a facility to potential accidents, and to provide a basis for improving safety in the use of radiation in medical applications. A further purpose of this report is to encourage readers to develop a questioning and learning attitude, adopt measures for the prevention of accidents, and prepare for mitigation of the consequences of accidents if they occur

Accidentes fuera del trabajo: análisis en el campamento minero de Toquepala 2002-2003

Directory of Open Access Journals (Sweden)

Raúl Gomero Cuadra

2005-06-01

Full Text Available En general, todas las empresas desarrollan programas para evitar o minimizar los accidentes del trabajo. Sin embargo, existe escasa información técnica relacionado a la prevalencia y costos derivados de los accidentes fuera del trabajo, lo que dificulta el análisis del problema. Objetivo: Revisar y analizar los descansos médicos en los trabajadores de nuestro campamento minero generados por accidentes considerados como particulares o fuera del trabajo. Materiales y métodos: El presente trabajo tiene un diseño transversal periódico, realizado en el Servicio de Salud Ocupacional del Hospital Toquepala. Los diagnósticos médicos fueron informados según el CIE-10 de la OMS. Para la clasificación de accidentes fuera del trabajo, se siguió la del programa de Loss Control Management del DNV, a la cual se le realizaron modificaciones de acuerdo al criterio y experiencia de los autores. Se revisaron 468 y 570 boletas de descanso médico generadas en los años 2002 y 2003 respectivamente. Resultados: Correspondieron al año 2002, 88 (18,8% descansos de accidentes fuera del trabajo, mientras que en el año 2003 fueron 99 (17,37%. La etiología de los accidentes fuera del trabajo fueron: de Transporte 11 (12,5% en el año 2002 y 12 (12,12% en el año 2003; del Hogar 25 (28,41% en el año 2002 y 20 (20,2% en el año 2003; Públicos 21 (23,86% en el año 2002 y 36 (36,36% en el año 2003. Conclusiones: Tenemos valores altos de accidentes fuera del trabajo con relación al número total de accidentes en nuestra empresa en los años 2002 y 2003, sin embargo, ninguno fatal. Además debemos orientar programas preventivos dirigidos hacia la seguridad vial y la buena práctica de deportes. Concluimos que es necesario incorporar el análisis de los accidentes fuera del trabajo con incapacidad temporal dentro del estudio de la morbilidad como parte del Diagnóstico de la Situación de Salud Laboral que confecciona el Médico ocupacional o del Trabajo

Accidental Kähler moduli inflation

International Nuclear Information System (INIS)

Maharana, Anshuman; Rummel, Markus; Sumitomo, Yoske

2015-01-01

We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small Kähler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil Kähler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model

Accidentes en el hogar

Directory of Open Access Journals (Sweden)

Nereida Pacios Alfonso

1999-04-01

Full Text Available Se realiza un estudio descriptivo de los accidentes domésticos ocurridos durante un año en la población de un consultorio del Médico de la Familia. Resultan más afectados los sujetos del sexo femenino y los grupos en edades extremas de la vida. El horario de la tarde fue el más peligroso. La relación con el uso de bebidas alcohólicas estuvo ausente en menores de 15 años y ancianos; en adultos jóvenes el dato requiere de otros estudios. Las contusiones por caídas fue el tipo más frecuente de lesión; los miembros superiores, la región corporal más afectada. Hubo secuelas en la quinta parte de los lesionados. Sólo cuatro de cada diez accidentes ocurridos se diagnostican en consulta. Más de la mitad de la morbilidad es oculta y cada lesionado pierde un promedio de 10 días de vida plenaA descriptive study of those home accidents reported by the population of a family physician´s office during a year was conducted. Females and the group at extreme ages of life were the most affected. Afternions were more dangerous. Drinking was not present among patients under 15 and aged people. As to young adults, this datum should be further studied. Contusions caused by falls were the most frequent type of injuries, whereas the upper limbs were the most injured. A fifth of these had sequelae. Only 4 accidents out of 10 were diagnosed at the physician´s office. More than falf of morbidity was hidden and every injured person lost an average of 10 days of full life

Main problems of external monitoring in the accidental zone

International Nuclear Information System (INIS)

Gavrikov, O.K.; Gul'din, A.N.; Komarov, V.I.; Malkov, V.L.; Smirnov, N.V.; Sukhoruchkin, A.K.; Proskuryakov, A.G.

1989-01-01

Operational experience of the external monitoring service during emergency response is analysed as applied to the problems of optimization of environmental monitoring under accidental conditions. Problems of rapid and strategical environmental radiation monitoring are considered

Accidentes biológicos en estudiantes de medicina de una universidad peruana: prevalencia, mecanismos y factores de riesgo

Directory of Open Access Journals (Sweden)

Elizabeth Inga

2010-03-01

Full Text Available Introducción: Una de las más serias amenazas que enfrentan los estudiantes de medicina durante su práctica clínica es la posibilidad de exposición a accidentes biológicos, debido en la mayoría de los casos a la inexperiencia y el escaso desarrollo de las habilidades manuales. Objetivos: Establecer la frecuencia, mecanismos, circunstancias y factores de riesgo de los accidentes biológicos ocurridos entre estudiantes de medicina. Diseño: Estudio descriptivo observacional de corte transversal. Institución: Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Estudiantes de medicina. Metodología: Se aplicó una encuesta estructurada anónima, voluntaria y autoadministrada. Principales medidas de resultados: Accidentes biológicos. Resultados: En total fueron 307 entrevistados. La prevalencia de accidentes biológicos en la población estudiada fue de 51,5% (158/307. La media de accidentes biológicos en el último año fue de 1,06. El 91,1% de los estudiantes del último año presentó al menos un accidente biológico, versus 11,9% en los estudiantes del primer año. Los estudiantes del último año informaron con más frecuencia accidentes de riesgo alto para transmisión de infecciones, siendo 47,6% por pinchazo con objeto punzocortante, y 80,6% tuvo exposición a sangre; los accidentes de riesgo alto son mucho más frecuentes en quirófanos y sala de partos (51,9%. Conclusiones: La prevalencia de accidentes biológicos fue 51,5%, siendo el pinchazo la forma más frecuente. Es necesario desarrollar estrategias que permitan velar por la bioseguridad de los estudiantes de medicina.

Comparison of intracranial computed tomographic (CT) findings in pediatric abusive and accidental head trauma

International Nuclear Information System (INIS)

Hymel, K.P.; Rumack, C.M.; Hay, T.C.; Strain, J.D.; Jenny, C.

1997-01-01

Background. Child abuse specialists rely heavily on diagnostic neuroimaging. Objectives. Study objectives were: (1) to compare the frequencies of six specific intracranial CT abnormalities in accidental and non-accidental pediatric head trauma, and (2) to assess interobserver agreement regarding these CT findings. Materials and methods. Three pediatric radiologists blindly and independently reviewed cranial CT scans of pediatric patients who sustained closed head trauma between 1991 and 1994. All patients were less than 4 years of age. Study cases included thirty-nine (50 %) with non-accidental head trauma and thirty-nine (50 %) with accidental head trauma. Each scan was evaluated for the presence or absence of the following six intracranial findings: (1) interhemispheric falx hemorrhage, (2) subdural hemorrhage, (3) large (non-acute) extra-axial fluid, (4) basal ganglia edema, (5) posterior fossa hemorrhage, and (6) frontal-parietal shearing tear(s). Interobserver agreement was calculated as the percentage of total cases in which all reviewers agreed a specific CT finding was present or absent. Diagnosis required independent agreement by all three pediatric radiologists. The frequencies of these six intracranial CT abnormalities were compared between the two study groups by Chi-square analysis and Fisher's exact test. Results. Interobserver agreement between radiologists was greater than 80 % for all lesions evaluated, with the exception of frontal-parietal shearing tear(s). Interhemispheric falx hemorrhage, subdural hemorrhage, large (non-acute) extra-axial fluid, and basal ganglia edema were discovered significantly more frequently in non-accidental trauma (P ≤.05). Conclusion. Although not specific for child abuse, discovery of these intracranial CT abnormalities in young patients should prompt careful evaluation of family and injury circumstances for indicators of non-accidental trauma. (orig.). With 6 figs., 2 tabs

Letalidad por accidentes de trabajo en Villa Clara

Directory of Open Access Journals (Sweden)

Miguel Gómez Vital

1999-01-01

Full Text Available Se valora la problemática de la letalidad por accidentes laborales en la provincia de Villa Clara, en el período comprendido entre 1987 y 1997. Se determinan las principales causas, y fue la conducta negligente del individuo la que más incidió. En los últimos años de la década del 80 se registraron más cantidad de muertes por accidentes de trabajo, los que ocurrieron fundamentalmente en el puesto laboral. Queda puntualizado el importante rol del equipo médico en instituciones laborales.The problem of letality from working accidents in the province of Villa Clara from 1987 to 1997 was evaluated. The main causes were also determined. Individual negligent behaviour proved to be the first cause. More deaths from working accidents were registered late in the 1980s. Most of these accidents occurred at the working place. It was stressed the important role played by the medical team at the working institutions

Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice

OpenAIRE

Yi, Ruo-Kun; Song, Jia-Le; Lim, Yaung-Iee; Kim, Yong-Kyu; Park, Kun-Young

2015-01-01

This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphata...

Solar radiation induced skin damage: review of protective and preventive options.

Science.gov (United States)

Svobodová, Alena; Vostálová, Jitka

2010-12-01

Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous options for such skin photoprotection. Endogenous systems for protection from solar radiation include melanin synthesis, epidermal thickening and an antioxidant network. Existing lesions are eliminated via repair mechanisms. Cells with irreparable damage undergo apoptosis. Excessive and chronic sun exposure however can overwhelm these mechanisms leading to photoaging and the development of cutaneous malignancies. Therefore exogenous means are a necessity. Exogenous protection includes sun avoidance, use of photoprotective clothing and sufficient application of broad-spectrum sunscreens as presently the best way to protect the skin. However other strategies that may enhance currently used means of protection are being investigated. These are often based on the endogenous protective response to solar light such as compounds that stimulate pigmentation, antioxidant enzymes, DNA repair enzymes, non-enzymatic antioxidants. More research is needed to confirm the effectiveness of new alternatives to photoprotection such as use of DNA repair and antioxidant enzymes and plant polyphenols and to find an efficient way for their delivery to the skin. New approaches to the prevention of skin damage are important especially for specific groups of people such as (young) children, photosensitive people and patients on immunosuppressive therapy. Changes in public awareness on the subject too must be made.

Suicide and accidental deaths in children and adolescents in England and Wales, 2001-2010.

Science.gov (United States)

Windfuhr, Kirsten; While, David; Hunt, Isabelle M; Shaw, Jenny; Appleby, Louis; Kapur, Nav

2013-12-01

To investigate the impact of narrative verdicts on suicide statistics among 10-19-year-olds; to identify the number and rate of suicide and accidental deaths, particularly in 10-14-year-olds. National cohort study. England and Wales. Mid-year population estimates from the Office for National Statistics (ONS) were used to calculate rates per 100,000 population for suicide (undetermined and suicide verdicts) and accidental deaths (poisoning, hanging) for those aged 10-14 and 15-19. Trends in rates over time (2001-2010) were investigated using Poisson regression. Interaction tests were carried out to determine differences in trends between the two time periods (2001-2005 and 2006-2010). There were 1523 suicides (2.25/100,000). Suicide rates were highest in those aged 15-19 years (4.04/100,000) and in males (3.14/100,000). Between 2001 and 2010, rates significantly decreased among those aged 15-19 years (incidence rate-ratio (IRR): 0.95; 95% CI 0.93 to 0.97), with no change in rates of accidental deaths (IRR: 1.01, 95% CI 0.95 to 1.07). However, there was a significant interaction between the two time periods for accidental poisonings (2001-2005: IRR: 0.79 (95% CI 0.69 to 0.91); 2006-2010: IRR: 1.01 (95% CI 0.89 to 1.15), interaction p=0.012) and accidental hangings (2001-2005: IRR: 0.93 (95% CI 0.76 to 1.14); 2006-2010: IRR: 1.25 (95% CI 1.04 to 1.49), interaction=0.01) Undetermined deaths significantly decreased among females aged 15-19 yeras (IRR: 0.93; 95% CI 0.88 to 0.98). There were no significant trends among 10-14-year-olds. Rates of suicide are higher among older adolescents and males. There was a significant fall in suicide rates in males aged 15-19 years that was not accounted for by changes in rates of accidental death. The absence of a significant trend in suicide or accidental deaths in those aged 10-14 years may have been the result of small numbers. However, monitoring should continue to identify longitudinal trends in all young people.

Accidental poisoning with autumn crocus.

Science.gov (United States)

Gabrscek, Lucija; Lesnicar, Gorazd; Krivec, Bojan; Voga, Gorazd; Sibanc, Branko; Blatnik, Janja; Jagodic, Boris

2004-01-01

We describe a case of a 43-yr-old female with severe multiorgan injury after accidental poisoning with Colchicum autumnale, which was mistaken for wild garlic (Allium ursinum). Both plants grow on damp meadows and can be confused in the spring when both plants have leaves but no blossoms. The autumn crocus contains colchicine, which inhibits cellular division. Treatment consisted of supportive care, antibiotic therapy, and granulocyte-directed growth factor. The patient was discharged from the hospital after three weeks. Three years after recovery from the acute poisoning, the patient continued to complain of muscle weakness and intermittent episodes of hair loss.

Results of dose calculations for NET accidental and normal operation releases of tritium and activation products

International Nuclear Information System (INIS)

Raskob, W.; Hasemann, I.

1992-08-01

This report documents conditions, data and results of dose calculations for accidental and normal operation releases of tritium and activation products, performed within the NET subtask SEP2.2 ('NET-Benchmark') of the European Fusion Technology Programme. For accidental releases, the computer codes UFOTRI and COSYMA for assessing the radiological consequences, have been applied for both deterministic and probabilistic calculations. The influence on dose estimates of different release times (2 minutes / 1 hour), two release heights (10 m / 150 m), two chemical forms of tritium (HT/HTO), and two different model approaches for the deposition velocity of HTO on soil was investigated. The dose calculations for normal operation effluents were performed using the tritium model of the German regulatory guidelines, parts of the advanced dose assessment model NORMTRI still under development, and the statistical atmospheric dispersion model ISOLA. Accidental and normal operation source terms were defined as follows: 10g (3.7 10 15 Bq) for accidental tritium releases, 10 Ci/day (3.7 10 11 Bq/day) for tritium releases during normal operation and unit releases of 10 9 Bq for accidental releases of activation products and fission products. (orig./HP) [de

Accidental transection of flexometallic endotracheal tube during partial maxillectomy

Directory of Open Access Journals (Sweden)

Sushma D Ladi

2011-01-01

Full Text Available We report a rare case of an 18-year-old female patient in whom accidental sectioning of flexometallic endotracheal tube occurred during partial maxillectomy for mass lesion under general anaesthesia. She was managed successfully by tracheostomy.

Further Highlighting on the Prevention of Oxidative Damage by Polyphenol-Rich Wine Extracts.

Science.gov (United States)

Salucci, Sara; Burattini, Sabrina; Giordano, Francesco Maria; Lucarini, Simone; Diamantini, Giuseppe; Falcieri, Elisabetta

2017-04-01

Wine contains various polyphenols such as flavonoids, anthocyanins, and tannins. These molecules are responsible for the quality of wines, influencing their astringency, bitterness, and color and they are considered to have antioxidant activity. Polyphenols, extracted from grapes during the processes of vinification, could protect the body cells against reactive oxygen species level increase and could be useful to rescue several pathologies where oxidative stress represents the main cause. For that, in this study, red and white wine, provided by an Italian vinery (Marche region), have been analyzed. Chromatographic and morphofunctional analyses have been carried out for polyphenol extraction and to evaluate their protective effect on human myeloid U937 cells exposed to hydrogen peroxide. Both types of wines contained a mix of phenolic compounds with antioxidant properties and their content decreased, as expected, in white wine. Ultrastructural observations evidenced that wines, in particular red wine, strongly prevent mitochondrial damage and apoptotic cell death. In conclusion, the considered extracts show a relevant polyphenol content with strong antioxidant properties and abilities to prevent apoptosis. These findings suggest, for these compounds, a potential role in all pathological conditions where the body antioxidant system is overwhelmed.

Computer code to assess accidental pollutant releases

International Nuclear Information System (INIS)

Pendergast, M.M.; Huang, J.C.

1980-07-01

A computer code was developed to calculate the cumulative frequency distributions of relative concentrations of an air pollutant following an accidental release from a stack or from a building penetration such as a vent. The calculations of relative concentration are based on the Gaussian plume equations. The meteorological data used for the calculation are in the form of joint frequency distributions of wind and atmospheric stability

Dietary Berries and Ellagic Acid Prevent Oxidative DNA Damage and Modulate Expression of DNA Repair Genes

Directory of Open Access Journals (Sweden)

Ramesh C. Gupta

2008-03-01

Full Text Available DNA damage is a pre-requisite for the initiation of cancer and agents that reduce this damage are useful in cancer prevention. In this study, we evaluated the ability of whole berries and berry phytochemical, ellagic acid to reduce endogenous oxidative DNA damage. Ellagic acid was selected based on > 95% inhibition of 8-oxodeoxyguosine (8-oxodG and other unidentified oxidative DNA adducts induced by 4-hydroxy-17B;-estradiol and CuCl2 in vitro. Inhibition of the latter occurred at lower concentrations (10 u(microM than that for 8-oxodG (100 u(microM. In the in vivo study, female CD-1 mice (n=6 were fed either a control diet or diet supplemented with ellagic acid (400 ppm and dehydrated berries (5% w/w with varying ellagic acid contents -- blueberry (low, strawberry (medium and red raspberry (high, for 3 weeks. Blueberry and strawberry diets showed moderate reductions in endogenous DNA adducts (25%. However, both red raspberry and ellagic acid diets showed a significant reduction of 59% (p < 0.001 and 48% (p < 0.01, respectively. Both diets also resulted in a 3-8 fold over-expression of genes involved in DNA repair such as xeroderma pigmentosum group A complementing protein (XPA, DNA excision repair protein (ERCC5 and DNA ligase III (DNL3. These results suggest that red raspberry and ellagic acid reduce endogenous oxidative DNA damage by mechanisms which may involve increase in DNA repair.

Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage.

Science.gov (United States)

Imam, S Z; Islam, F; Itzhak, Y; Slikker, W; Ali, S F

2000-09-01

Methamphetamine (METH) is a neurotoxic psychostimulant that produces catecholaminergic brain damage by producing oxidative stress and free radical generation. The role of oxygen and nitrogen radicals is well documented as a cause of METH-induced neurotoxic damage. In this study, we have obtained evidence that METH-induced neurotoxicity is the resultant of interaction between oxygen and nitrogen radicals, and it is mediated by the production of peroxynitrite. We have also assessed the effects of inhibitors of neuronal nitric oxide synthase (nNOS) as well as scavenger of nitric oxide and a peroxynitrite decomposition catalyst. Significant protective effects were observed with the inhibitor of nNOS, 7-nitroindazole (7-NI), as well as by the selective peroxynitrite scavenger or decomposition catalyst, 5,10,15,20-tetrakis(2,4,6-trimethyl-3,5-sulfonatophenyl)porphyrinato iron III (FeTPPS). However, the use of a nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO), did not provide any significant protection against METH-induced hyperthermia or peroxynitrite generation and the resulting dopaminergic neurotoxicity. In particular, treatment with FeTPPS completely prevented METH-induced hyperthermia, peroxynitrite production, and METH-induced dopaminergic depletion. Together, these data demonstrate that METH-induced dopaminergic neurotoxicity is mediated by the generation of peroxynitrite, which can be selectively protected by nNOS inhibitors or peroxynitrite scavenger or decomposition catalysts.

Limits to radioactive effluents and countermeasures in accidental situations

International Nuclear Information System (INIS)

Nowotny, G.; Gonzalez, A.

1978-01-01

The paper discusses the criteria used by the Argentine Atomic Energy Commission, as competent authority, to set limits to radioactive effluents from nuclear installations. It also discusses the selection of action levels for carrying out countermeasures in accidental situations. (author)

The LoTrach system: its role in the prevention of ventilator-associated pneumonia.

Science.gov (United States)

Fletcher, Andrew J W; Ruffell, Alison J; Young, Peter J

2008-01-01

To discuss the development of the LoTrach system in light of current evidence around the prevention of ventilator-associated pneumonia (VAP) and its practical application in the intensive care setting. VAP causes substantial morbidity and mortality in ventilated patients in the Intensive Care Unit (ICU), increases length of stay in ICU and is extremely costly. Strategies are needed to reduce the risk of VAP. We examine the need for an endotracheal tube (ETT) specifically designed for the critically-ill patient, the development of the LoTrach system from conception to production, and the role of the various components of the system in preventing VAP. Early issues in implementing this revolutionary equipment into ICU are explored and three case studies highlight advantages of this system. The LoTrach system has been designed to facilitate the provision of a number of evidence-based interventions that have been shown to reduce VAP. Pulmonary aspiration is ubiquitous with conventional cuffs but prevented by the cuff of the LoTrach system when held at a constant and safe pressure against the tracheal wall with a cuff pressure controller. Other aspects incorporated in the ETT are aimed at clearing the secretions from the subglottic space, preventing tube occlusion and accidental extubation, and avoiding damage to the airway. In this way the LoTrach system employs a multifactorial approach to the prevention of VAP and the cost savings from LoTrach rather than a standard ETT will be considerable because of an average 3 day reduction in ICU length of stay related to this. It thus has the potential to be a very useful tool in the ICU setting in the prevention of VAP.

Accidental Childhood Poisoning in Enugu, South‑East, Nigeria

African Journals Online (AJOL)

Accidental childhood poisoning is one of the recognized causes of ... are those undergoing the oral phase of their psychological development. .... Palm oil ingestion and induction of emesis were the most commonly used ... poisoning. Kerosene is found in most homes in Nigeria as it is the ... Ingestion of coconut water. 2. 3.1.

Natural convection accidental conditions in nuclear power plants

International Nuclear Information System (INIS)

Delmastro, D.F.; Clausse, A.

1990-01-01

Under certain conditions, wether accidental or in nuclear reactor design, a nuclear reactor core may be found to be refrigerated by a fluid in natural circulation. Before the possible density waves phenomenon occurrence, it is essential to have a good knowledge of the flow evolution and thermohydraulic variables under these conditions. (Author) [es

Accidental Childhood Poisoning in Enugu, South‑East, Nigeria ...

African Journals Online (AJOL)

Background: Accidental childhood poisoning is one of the recognized causes of morbidity and mortality in children under the age of 5 years worldwide. The prevalence and type of substance ingested vary from place to place and over time. Aim: This study was conducted with the aim of ascertaining the frequency and ...

Effect of radiation damage on operating safety of steel pressure vessels of nuclear reactors

International Nuclear Information System (INIS)

Vacek, M.; Havel, S.; Stoces, B.; Brumovsky, M.

1980-01-01

The effects are assessed of the environment upon mechanical properties of steel used generally for pressure vessels of light water nuclear reactors. Changes caused by radiation affect the reliability of vessels. Deterioration of steel properties is mainly due to neutron radiation. The article deals with factors bearing upon damage and with methods allowing to evaluate the reliability of vessels and predict their service life. Operating reliability of vessels is very unfavourably affected by planned and accidental reactor transients. (author)

FACTORES DE RIESGO QUE OCASIONAN ACCIDENTES LABORALES EN EL PERSONAL DE ENFERMERÍA DE UNA CLÍNICA ACREDITADA DE LA CIUDAD DE AREQUIPA, 2007-2008

OpenAIRE

GARCIA SUTTA, PATRICIA CONCEPCION

2014-01-01

FACTORES DE RIESGO CONCEPTUALIZACIÓN TIPOS RIESGOS NO MECÁNICOS RUIDOS RADIACIONES IONIZANTES ILUMINACIÓN CALOR FRÍO RIESGOS FÍSICOS MECÁNICOS RIESGOS QUÍMICOS RIESGOS ERGONÓMICOS POSTURA RIESGOS BIOLÓGICOS CARGA DE TRABAJO LABORAL DEFINICIÓN ACCIDENTES LABORALES ACCIDENTE CAUSAS BÁSICAS Y CAUSAS INMEDIATAS ACCIDENTES LABORALES CAUSAS DE LOS ACCIDENTES TIPOS DE ACCIDENTE TIPOS DE ACCIDENTES LABORALES

Nerve damage from diabetes - self-care

Science.gov (United States)

... this page: //medlineplus.gov/ency/patientinstructions/000326.htm Nerve damage from diabetes - self-care To use the ... or at other unusual times. Treating and Preventing Nerve Damage from Diabetes Treating diabetic neuropathy can make ...

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

Directory of Open Access Journals (Sweden)

Tatyana A. Kuznetsova

2014-01-01

Full Text Available An important problem of treating patients with endotoxemia is to find drugs to reduce the negative effects of endotoxin on the organism. We tested fucoidan (sulfated polysaccharide from the brown alga Fucus evanescens as a potential drug in a mouse model of endotoxemia inducted by lipopolysaccharide (LPS. The survival time of mice injected with LPS increased under fucoidan treatment compared with the group of mice injected with LPS only. The preventive administration of fucoidan to mice with endotoxemia resulted in inhibition of increased levels of proinflammatory cytokines (TNFα and IL-6, as well as decreasing of the processes of hypercoagulability. The parenteral or per os administration of fucoidan resulted in decreasing the degree of microcirculatory disorders and secondary dystrophic-destructive changes in parenchymal organs of mice with endotoxemia. Taken together, these results demonstrate that fucoidan prevents endotoxin-induced damage in a mouse model of endotoxemia and increases the mice’s resistance to LPS.

Leading global projects for professional and accidental project leaders

CERN Document Server

Moran, Robert T

2008-01-01

This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

Non-accidental injury: a review of the radiology

International Nuclear Information System (INIS)

Carty, H.

1997-01-01

There have been many descriptions of the radiological features of non-accidental injury since John Caffey introduced the concept of inflicted injury and initially described some of the patterns of injury. Since then, our understanding of the radiologically detectable injuries has increased. This article provides a review of our current understanding of the lesions. (orig.)

Ethical and Unethical Methods of Plagiarism Prevention in Academic Writing

Science.gov (United States)

Bakhtiyari, Kaveh; Salehi, Hadi; Embi, Mohamed Amin; Shakiba, Masoud; Zavvari, Azam; Shahbazi-Moghadam, Masoomeh; Ebrahim, Nader Ale; Mohammadjafari, Marjan

2014-01-01

This paper discusses plagiarism origins, and the ethical solutions to prevent it. It also reviews some unethical approaches, which may be used to decrease the plagiarism rate in academic writings. We propose eight ethical techniques to avoid unconscious and accidental plagiarism in manuscripts without using online systems such as Turnitin and/or…

Sodium fire studies in France. Safety experiments applied to fast reactors

International Nuclear Information System (INIS)

Fruchard, Y.; Colome, J.; Malet, J.C.; Berlin, M.; Duverger de Cuy, G.; Justin, J.; Duco, J.

1976-01-01

In fast reactors, the risk of sodium fires must be analyzed in detail and the consequences of an accidental fire must be known precisely. Beyond the search for prevention and detection means, techniques must be developed to set up a limit to damages created by an accidental fire: extinguishing, aerosol confinement, protection of the reactor structures. The program developed by the Nuclear Safety Department of the Commissariat a l'Energie Atomique to solve these various problems is described. The main results and their applications to the Super-Phenix reactor are presented [fr

Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice.

Science.gov (United States)

Yi, Ruo-Kun; Song, Jia-Le; Lim, Yaung-Iee; Kim, Yong-Kyu; Park, Kun-Young

2015-03-01

This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase. TMC pretreatment also increased the hepatic levels of hepatic catalase, superoxide dismutase, glutathione peroxidase, and glutathione, and reduced serum levels of the inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 in mice administered APAP (Phepatic mRNA levels of TNF-α, IL-1β, IL-6, COX-2, and iNOS by 87%, 84%, 89%, 85%, and 88%, respectively, in mice treated with APAP (Phepatic damage.

Features of risks, damage claims processing and damage prevention overseas. Pt. 1

Energy Technology Data Exchange (ETDEWEB)

Splittgerber, E

1981-01-01

In opening up new raw material resources in remote locations and in the erection of industrial installations in overseas countries, manufacturers are often confronted with additional, unusual and hitherto unknown risks which can have considerable influence upon the orderly and timely execution of their projects. In Part I, various risk factors are considered from the experiences of Allianz as technical insurer in foreign damages connected with plant, civil and installation work insurance. The influence of climatic conditions upon damage events is illustrated with examples and the effects of storm, sand storm, flooding and earthquake discussed using a world map of natural dangers. The customs of people from culturally different nations and races, dictated as they often are by religion, must be taken into account by site managers and other staff on the building sites. The necessity for improvisations on building sites far from home and the limits of such improvisations are also discussed.

Limits for Beam Induced Damage: Reckless or too Cautious?

CERN Document Server

Bertarelli, A; Carra, F; Cerutti, F; Dallocchio, A; Mariani, N; Peroni, L; Scapin, M

2011-01-01

Accidental events implying direct beam impacts on collimators are of the utmost importance as they may lead to serious limitations of the overall LHC Performance. In order to assess damage threshold of components impacted by high energy density beams, entailing changes of phase and extreme pressures, state-of-the-art numerical simulation methods are required. In this paper, a review of the different dynamic response regimes induced by particle beams is given along with an indication of the most suited tools to treat each regime. Particular attention is paid to the most critical case, that of shock waves, for which standard Finite Element codes are totally unfit. A novel category of numerical tools, named Hydrocodes, has been adapted and used to analyse the consequences of an asynchronous beam abort on Phase 1 Tertiary Collimators (TCT). A number of simulations has been carried out with varying beam energy, number of bunches and bunch sizes allowing to identify different damage levels for the TCT up to catastr...

The Accidental Transgressor: Morally-Relevant Theory of Mind

Science.gov (United States)

Killen, Melanie; Mulvey, Kelly Lynn; Richardson, Cameron; Jampol, Noah; Woodward, Amanda

2011-01-01

To test young children's false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N=162) at 3.5, 5.5, and 7.5 years of age were administered three tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an "accidental transgressor" task, which measured a…

[Central cervical cord syndrome: a case report on rehabilitation, with special references to accidental falls in the elderly].

Science.gov (United States)

Ina, G; Eto, F; Furuichi, T; Suzuki, H; Shibuya, K

1995-03-01

An 81-year-old man with Parkinson's disease was admitted to our hospital with impaired function of all extremities. Four weeks before his symptoms developed, he had tripped on the steps, fallen and bruised his jaw. Following this episode he experienced a few more falls inside his house. On examination his greatest weakness was in the hands and wrists. He was hyper-reflexic in all extremities and had bilateral Babinski's sign. He could not walk and needed physical assistance in most of his daily living activities. X-ray films of the cervical spine showed significant degenerative changes. The magnetic resonance images suggested central cervical cord damage at the level of the C6 vertebral body. After three months' rehabilitation treatment, he became able to walk with a cane and became independent in all the basic activities of daily living except for bathing. He never regained skillful function of his hands despite later levodopa treatment of Parkinson's disease. His clinical features were consistent with the central cervical cord syndrome, described by Schnneider and co-workers in 1954. This syndrome may occur as a result of hyperextension neck injury, occasionally associated with an accidental fall in the elderly with cervical spondylosis. Thirteen patients with cervical spinal cord injury above 65 of age were admitted to our department from 1983 to 1993. Six of them presented with the central cervical cord syndrome, and all patients had a history of accidental injuries related to falling.

Social referencing "Mr. Yuk": the use of emotion in a poison prevention program.

Science.gov (United States)

Pooley, Amanda J; Fiddick, Laurence

2010-05-01

To assess whether disgust, the emotion depicted on poison control "Mr. Yuk" stickers, conveys an age-appropriate message to young children. Two preliminary studies (both N = 48) were conducted with adults to assess what facial expressions of emotion they associated with child and adult violations of precautionary rules. Subsequently, 20 3-year-olds and 35 4-year-olds were tested on age-appropriate scenarios to determine what facial expressions of emotion they associate with accidental poisonings. Adults associated violations of precautionary rules, regardless of whether they involved children or adults and physical injury or accidental poisonings, with facial expressions of fear, not disgust. The study conducted with children indicated that they likewise anticipated facial expressions of fear in response to accidental poisonings. The disgust displayed on Mr. Yuk stickers does not appear to convey a valid emotional message, regardless of whether the stickers are used for preventive or educational purposes.

Accidental degeneracy of double Dirac cones in a phononic crystal

KAUST Repository

Chen, Ze-Guo; Ni, Xu; Wu, Ying; He, Cheng; Sun, Xiao-Chen; Zheng, Li-Yang; Lu, Ming-Hui; Chen, Yan-Feng

2014-01-01

Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

Accidental degeneracy of double Dirac cones in a phononic crystal

KAUST Repository

Chen, Ze-Guo

2014-04-09

Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

Pipeline monitoring using acoustic principal component analysis recognition with the Mel scale

International Nuclear Information System (INIS)

Wan, Chunfeng; Mita, Akira

2009-01-01

In modern cities, many important pipelines are laid underground. In order to prevent these lifeline infrastructures from accidental damage, monitoring systems are becoming indispensable. Third party activities were shown by recent reports to be a major cause of pipeline damage. Potential damage threat to the pipeline can be identified by detecting dangerous construction equipment nearby by studying the surrounding noise. Sound recognition technologies are used to identify them by their sounds, which can easily be captured by small sensors deployed along the pipelines. Pattern classification methods based on principal component analysis (PCA) were used to recognize the sounds from road cutters. In this paper, a Mel residual, i.e. the PCA residual in the Mel scale, is proposed to be the recognition feature. Determining if a captured sound belongs to a road cutter only requires checking how large its Mel residual is. Experiments were conducted and results showed that the proposed Mel-residual-based PCA recognition worked very well. The proposed Mel PCA residual recognition method will be very useful for pipeline monitoring systems to prevent accidental breakage and to ensure the safety of underground lifeline infrastructures

Accidental radioisotope burns - Management of late sequelae

Directory of Open Access Journals (Sweden)

Varghese Bipin

2010-10-01

Full Text Available Accidental radioisotope burns are rare. The major components of radiation injury are burns, interstitial pneumonitis, acute bone marrow suppression, acute renal failure and adult respiratory distress syndrome. Radiation burns, though localized in distribution, have systemic effects, and can be extremely difficult to heal, even after multiple surgeries. In a 25 year old male who sustained such trauma by accidental industrial exposure to Iridium192 the early presentation involved recurrent haematemesis, pancytopenia and bone marrow suppression. After three weeks he developed burns in contact areas in the left hand, left side of the chest, abdomen and right inguinal region. All except the inguinal wound healed spontaneously but the former became a non-healing ulcer. Pancytopenia and bone marrow depression followed. He was treated with morphine and NSAIDs, epidural buprinorphine and bupivicaine for pain relief, steroids, antibiotics followed by wound excision and reconstruction with tensor fascia lata(TFL flap. Patient had breakdown of abdominal scar later and it was excised with 0.5 cm margins up to the underlying muscle and the wound was covered by a latissimis dorsi flap. Further scar break down and recurrent ulcers occurred at different sites including left wrist, left thumb and right heel in the next two years which needed multiple surgical interventions.

Ventricular fibrillation after accidental injection of bupivacaine into the pericardium

NARCIS (Netherlands)

Even, B. J.; de Jongh, R. F.; de Hert, S. G.

1992-01-01

A postoperative cardiac surgical patient developed ventricular fibrillation immediately after accidental pericardial injection of bupivacaine at room temperature. The possible causes, which include systemic toxicity, local vasoconstriction with myocardial ischaemia, local toxic effect of bupivacaine

Accidentes de trabajo en el Hospital Clínico de la Universidad de Chile durante el año 2007

Directory of Open Access Journals (Sweden)

Carlos Valdés

2011-01-01

Full Text Available Objetivo: Conocer el número de los accidentes laborales en el Hospital Clínico de la Universidad de Chile (HCUCH el año 2007 y su caracterización de acuerdo a variables como: sexo, edad, tipo de lesión, día de la semana, mes del año, cargo desempeñado y días perdidos. Diseño: Estudio descriptivo, transversal, retrospectivo y observacional. Lugar: Hospital Clínico de la Universidad de Chile (HCUCH. Participantes: Accidentes laborales reportados entre el 1 de Enero y el 31 de Diciembre del 2007. Intervención: Se utilizó la base de datos del Registro de Notificación de Accidentes Laborales, proporcionada por el Departamento de Prevención de Riesgos del HCUCH Principales medidas de Resultados: Porcentajes y Medidas de Tendencia Central, tabuladas en una base de datos con ayuda del programa Microsoft Excel 2003 para Windows ®. Resultados: Se observan 104 accidentes laborales, con un mayor número de eventos en el personal femenino (69,2%, en el rango etareo de 30-39 años (34,3%, el tipo de lesión más frecuente fueron las contusiones policontusiones (39,4%, el grupo más accidentado fue los auxiliares y técnicos (71.1%. El estudio por días de la semana revela que hay más accidentes los días miércoles y jueves (43,27% y los meses del año con más accidentes fueron enero, agosto y diciembre. La mayor cantidad de accidentes laborales comprometen entre 1 a 5 días perdidos. Conclusiones: Durante el año 2007, se pesquisó 104 accidentes laborales, lo que significó 804 días de ausentismo. Este estudio muestra que el sexo femenino, tener entre 30-39 años y ejercer como auxiliar o técnico fueron factores de asociados al incremento de los accidentes laborales. Palabras clave: Accidentes de trabajo, ausentismo, notificación de accidentes de trabajo.

Accidental bound states in the continuum in an open Sinai billiard

Energy Technology Data Exchange (ETDEWEB)

Pilipchuk, A.S. [Kirensky Institute of Physics, Federal Research Center KSC SB RAS, 660036 Krasnoyarsk (Russian Federation); Siberian Federal University, 660080 Krasnoyarsk (Russian Federation); Sadreev, A.F., E-mail: almas@tnp.krasn.ru [Kirensky Institute of Physics, Federal Research Center KSC SB RAS, 660036 Krasnoyarsk (Russian Federation)

2017-02-19

The fundamental mechanism of the bound states in the continuum is the full destructive interference of two resonances when two eigenlevels of the closed system are crossing. There is, however, a wide class of quantum chaotic systems which display only avoided crossings of eigenlevels. As an example of such a system we consider the Sinai billiard coupled with two semi-infinite waveguides. We show that notwithstanding the absence of degeneracy bound states in the continuum occur due to accidental decoupling of the eigenstates of the billiard from the waveguides. - Highlights: • Bound states in the continuum in open chaotic billiards occur to accidental vanishing of coupling of eigenstate of billiard with waveguides.

A world first to cap them all

Energy Technology Data Exchange (ETDEWEB)

Taylor, C.J.

1981-05-01

A new, more powerful cap lamp has a sealed lead-acid battery which never needs refilling and which will not spill liquid, even if the case is damaged. The plastic case is flame resistant and meets South African requirements for use underground. A new type of cable lock prevents accidental disconnection.

Accidental deposition of local anaesthetic in the subdural space ...

African Journals Online (AJOL)

The incidence of accidental injection of local anaesthetic into the subdural space during neuraxial blockade is rare. The presentation of unexplainable clinical signs that do not match the clinical picture of subarachnoid or intravascular injection of the local anaesthetic agent should invoke high suspicion of unintentional ...

Accidental Carbon Monoxide Poisonings in Adana, Turkey: A 14-year Study

Directory of Open Access Journals (Sweden)

Murat Darçın

2017-03-01

Full Text Available Aim: Carbon monoxide (CO is often referred to as the “silent killer” because its victims cannot see it, smell it or taste it. CO is responsible for a large percentage of the accidental poisonings and deaths reported throughout the world. CO poisoning therefore is considered a serious global health threat. The aim of the present study was to describe the cases of CO poisoning in a rural areas of Adana, Turkey between 2002 and 2015 based on data collected from incident reports. Methods: The cases of accidental CO poisoning were statistically analyzed. During that period, 74 incidents occurred and 154 people were poisoned by accidental CO poisoning. Results: The results of this analysis indicate that men and adults aged ≥65 years were more likely to die from CO poisoning than others. The number of CO poisoning cases was highest during the heating season. The majority (72% of poisoning resulting in hospitalization with a life-threatening condition or death occurred within the home. Conclusion: CO poisoning is a serious danger. People must be informed about this hazard. By educating risk groups about the dangers of CO poisoning, it is possible to save many lives as well as reduce the health risks.

Chemical Spill Prevention, Control, and Countermeasures Plan: 100 Areas

Energy Technology Data Exchange (ETDEWEB)

Chien, Y.M.

1989-06-01

The purpose of this Chemical Spill Prevention, Control, and Countermeasures (SPCC) Plan is to identify the chemical spill control practices, procedures, and containment devices Westinghouse Hanford Company (Westinghouse Hanford) employs to prevent a reportable quantity (RQ) of a hazardous substance (as defined in 40 CFR Part 302) from being released to the environment. The chemical systems and chemical storage facilities in the 100 Areas are described. This document traces the ultimate fate of accidental chemical spills at the 100 Areas. Also included in the document destinations, spill containment devices, and systems surveillance frequencies. 2 tabs.

Chemical Spill Prevention, Control, and Countermeasures Plan: 100 Areas

International Nuclear Information System (INIS)

Chien, Y.M.

1989-06-01

The purpose of this Chemical Spill Prevention, Control, and Countermeasures (SPCC) Plan is to identify the chemical spill control practices, procedures, and containment devices Westinghouse Hanford Company (Westinghouse Hanford) employs to prevent a reportable quantity (RQ) of a hazardous substance (as defined in 40 CFR Part 302) from being released to the environment. The chemical systems and chemical storage facilities in the 100 Areas are described. This document traces the ultimate fate of accidental chemical spills at the 100 Areas. Also included in the document destinations, spill containment devices, and systems surveillance frequencies. 2 tabs

Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells.

Science.gov (United States)

Lai, Kar Neng; Chan, Loretta Y Y; Tang, Sydney C W; Leung, Joseph C K

2006-05-01

Ganoderma lucidum (Ganoderma or lingzhi) is widely used as an alternative medicine remedy to promote health and longevity. Recent studies have indicated that components extracted from Ganoderma have a wide range of pharmacological actions including suppressing inflammation and scavenging free radicals. We recently reported that tubular secretion of interleukin-8 (IL-8) induced by albumin is important in the pathogenesis of tubulointerstitial injury in the proteinuric state. In this study, we explored the protective effect of Ganoderma extract (LZ) on albumin-induced kidney epithelial injury. Growth arrested human proximal tubular epithelial cells (PTECs) were incubated with 0.625 to 10 mg/ml human serum albumin (HSA) for up to 72 h. HSA induced DNA damage and apoptosis in PTEC in a dose- and time-dependent manner. Co-incubation of PTEC with 4-64 microg/ml LZ significantly reduced the oxidative damage and cytotoxic effect of HSA in a dose-dependent manner (PGanoderma (16 microg/ml). To explore the components of LZ that exhibited most protective effect in HSA-induced PTEC damages, LZ was further separated into two sub-fractions, LZF1 (MW effective in reducing sICAM-1 released from HSA-activated PTEC whereas the high molecular weight LZ (unfractionated LZ) was more effective in diminishing IL-8 production. Our results suggest that Ganoderma significantly reduces oxidative damages and apoptosis in PTEC induced by HSA. The differential reduction of IL-8 or sICAM-1 released from HSA-activated PTEC by different components of the LZ implicates that components of Ganoderma with different molecular weights could play different roles and operate different mechanisms in preventing HSA-induced PTEC damage.

Brugada syndrome unmasked by accidental inhalation of gasoline vapors

DEFF Research Database (Denmark)

Kranjcec, Darko; Bergovec, Mijo; Rougier, Jean-Sébastien

2007-01-01

Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline...

Accidental outcomes guide punishment in a "trembling hand" game.

Directory of Open Access Journals (Sweden)

Fiery Cushman

Full Text Available How do people respond to others' accidental behaviors? Reward and punishment for an accident might depend on the actor's intentions, or instead on the unintended outcomes she brings about. Yet, existing paradigms in experimental economics do not include the possibility of accidental monetary allocations. We explore the balance of outcomes and intentions in a two-player economic game where monetary allocations are made with a "trembling hand": that is, intentions and outcomes are sometimes mismatched. Player 1 allocates $10 between herself and Player 2 by rolling one of three dice. One die has a high probability of a selfish outcome, another has a high probability of a fair outcome, and the third has a high probability of a generous outcome. Based on Player 1's choice of die, Player 2 can infer her intentions. However, any of the three die can yield any of the three possible outcomes. Player 2 is given the opportunity to respond to Player 1's allocation by adding to or subtracting from Player 1's payoff. We find that Player 2's responses are influenced substantially by the accidental outcome of Player 1's roll of the die. Comparison to control conditions suggests that in contexts where the allocation is at least partially under the control of Player 1, Player 2 will punish Player 1 accountable for unintentional negative outcomes. In addition, Player 2's responses are influenced by Player 1's intention. However, Player 2 tends to modulate his responses substantially more for selfish intentions than for generous intentions. This novel economic game provides new insight into the psychological mechanisms underlying social preferences for fairness and retribution.

Distribución espacial de los accidentes y enfermedades relacionados con el trabajo en el Perú, 2012-2014

Directory of Open Access Journals (Sweden)

Akram Hernández-Vásquez

2016-01-01

Full Text Available Se analizaron geoespacialmente los accidentes, incidentes peligrosos y enfermedades ocupacionales que se reportaron a nivel regional en el Perú (2012-2014. 52 887 eventos se notificaron entre accidentes de trabajo (93%, incidentes peligrosos (5,1%, enfermedades ocupacionales (1% y accidentes mortales (0,9%. Se evidenciaron altas tasas de accidentes mortales en Pasco, Callao, Lima, Moquegua y Arequipa. Callao y Lima son las regiones con tasas más altas de accidentes de trabajo. Las mayores tasas de incidentes peligrosos se reportaron en Arequipa, Callao, Lima, Ica y Piura. Las enfermedades ocupacionales se distribuyeron con altas tasas en Huancavelica, Ancash, Pasco, Callao y Cusco. La explotación de minas y canteras (49,2%; seguida por la industria manufacturera (23,4%; y, la construcción (8% son las actividades económicas que concentraron elevadas tasas de enfermedades ocupacionales. Se concluye que existen altas tasas y patrones espaciales comunes de accidentabilidad en el Perú que pueden servir para enfocar intervenciones.

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

Directory of Open Access Journals (Sweden)

Alexandra Amaro-Ortiz

2014-05-01

Full Text Available Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of “realized” solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.

Dealing with flood damages: will prevention, mitigation, and ex post compensation provide for a resilient triangle?

Directory of Open Access Journals (Sweden)

Cathy Suykens

2016-12-01

Full Text Available There is a wealth of literature on the design of ex post compensation mechanisms for natural disasters. However, more research needs to be done on the manner in which these mechanisms could steer citizens toward adopting individual-level preventive and protection measures in the face of flood risks. We have provided a comparative legal analysis of the financial compensation mechanisms following floods, be it through insurance, public funds, or a combination of both, with an empirical focus on Belgium, the Netherlands, England, and France. Similarities and differences between the methods in which these compensation mechanisms for flood damages enhance resilience were analyzed. The comparative analysis especially focused on the link between the recovery strategy on the one hand and prevention and mitigation strategies on the other. There is great potential within the recovery strategy for promoting preventive action, for example in terms of discouraging citizens from living in high-risk areas, or encouraging the uptake of mitigation measures, such as adaptive building. However, this large potential has yet to be realized, in part because of insufficient consideration and promotion of these connections within existing legal frameworks. We have made recommendations about how the linkages between strategies can be further improved. These recommendations relate to, among others, the promotion of resilient reinstatement through recovery mechanisms and the removal of legal barriers preventing the establishment of link-inducing measures.

Atmospheric Dispersion Assessment for Potential Accidental Releases at Yonggwang Nuclear Power Plants

International Nuclear Information System (INIS)

Na, Man Gyun; Sim, Young Rok; Jung, Chul Kee; Lee, Goung Jin; Kim, Soong Pyung; Chung, Sung Tai

2000-01-01

XOQ DW code is currently used to assess the atmospheric dispersion for the routine releases of radioactive gaseous effluents at Yonggwang nuclear power plants. This code was developed based on XOQDOQ code and an additional code is required to assess the atmospheric dispersion for potential accidental releases. In order to assess the atmospheric dispersion for the accidental releases, XOQAR code has been developed by using PAVAN code that is based on Reg. Guide 1.145. The terrain data of XOQ DW code inputs and the relative concentrations (X/Q) of XOQ DW code outputs are used as the inputs of the XOQAR code through the interface with XOQ DW code. By using this code, the maximum values of X/Q at exclusion area and low population zone boundaries except for sea areas were assessed as 1.33 x 10 -4 and 7.66 x 10 -6 sec/m 3 , respectively. Through the development of this code, a code system is prepared for assessing the atmospheric dispersion for the accidental releases as well as the routine releases. This developed code can be used for other domestic nuclear power plants by modifying the terrain input data

Los accidentes laborales en el area IV: Años 1990-1993

Directory of Open Access Journals (Sweden)

Juan Pablo Hernández Fruto

1997-12-01

Full Text Available Se realizó un estudio descriptivo de la accidentalidad laboral en la Fábrica de Cemento del municipio Cienfuegos, situada en el territorio del área de salud IV del propio municipio, con el objetivo de analizar la frecuencia de los accidentes en el cuatrienio 90-93, así como identificar las causas que contribuyeron a su incidencia en esta etapa. El grupo de estudio lo forman 80 accidentes ocurridos en el período donde resultaron lesionados 79 trabajadores y 2 que fallecieron. Las variables estudiadas fueron el sexo, la edad, la antigüedad laboral y el área de trabajo. Resultó como muy riesgosa la edad entre los 30 y los 50 años, con una antigüedad laboral de más de 11 y menos de 15 años, el horario de la madrugada fue el intervalo de tiempo más peligroso para los obreros de las áreas de los molinos, hornos y talleres. Es por estos resultados que se considera necesario el incremento de la prevención en estos puestos de trabajo.A descriptive study of the occupational accidents occurred at the Factory of Cement located in the territory of the health area IV in the municipality of Cienfuegos, was conducted aimed at analyzing the frequency of accidents during the 4-years period 1990-93, and at identifying the causes contributing to the their incidence at this stage. The case-based study is composed of 80 accidents that took place during this period, in which 79 workers were injured and 2 died. The variable studied were sex, age, working seniority, and working area. Age between 30 and 50 proved to be very risks with a working seniority of more than 11 and less than 15 years. The night shift was the most dangerous for people working in mills, furncaces and workshops. According to these results, it is considered as neccesary the increase of prevention in these jobs.

Safety problems, symptomatic oriented accident regulations, influence of nuclear energetic on ecology of the Slovak Republic

International Nuclear Information System (INIS)

Palenikova, M.

2002-01-01

IAEA initiated in 1990 the program on help of the countries of Eastern Europe and of the former Soviet Union at evaluating of the safety of their first generation nuclear power reactors of the type WWER 440/223. The main aim of this program was to identify the main design and operational safety problems, to determine international consensus on priorities of safety improvements, to provide the help in the assessment of completeness and adequacy of programs of safety improvements: What are the safety problems; What is the safety importance of problems; What is done for prevention from damage of nuclear power plant; and of three barriers: the tasks MOD V-2 NPP; What is done for reducing of damage consequences; PHP, PASS (post-accidental directives and post-accidental monitoring). (author)

Experimental Investigation into Vibration Characteristics for Damage Minimization in a Lapping Process

Directory of Open Access Journals (Sweden)

J. Suwatthikul

2016-01-01

Full Text Available Lapping machines are used in a hard disk rough lapping process where a workpiece (a wafer row bar is locked with a robot arm and rubbed on a lap plate. In this process, the lap plate’s condition and lifetime are among important concerned factors. The lifetime can be too short due to the plate being accidentally scratched by the workpiece during lapping. This problem leads to undesired consequences such as machine downtime and excessive plate material usage. This paper presents an experimental investigation into vibration characteristics of passed and failed lapping scenarios and discusses a potential solution to minimize the serious damage so-called “plate scratch” which intermittently occurs in such process. The experimental results show that, by in situ monitoring vibration and utilizing artificial intelligence, damage minimization can be possible.

Ultraviolet radiation, sun damage and preventing

International Nuclear Information System (INIS)

Johnsen, B.; Christensen, T.; Nilsen, L.T.; Hannevik, M.

2013-01-01

The report focuses on the large impact of health damages due to excessive UV exposure from natural sun. The first part of the report gives background information on factors significantly affecting the intensity of UV radiation. The second part gives an overview of health effects related to UV exposure, with recommendations on how to avoid excessive UV exposure and still enjoy the positive sides of outdoor activity. The report is intended to contribute to informational activities about sun exposure as recommended by the World Health Organisation and the World Meteorology Organisation. (Author)

Accidental hand grenade blast injuries in the Transkei region of ...

African Journals Online (AJOL)

Case Study: Accidental hand grenade blast injuries in the Transkei region of South Africa. 348. Vol 51 No 4. SA Fam ... There is some evidence that a substantial number of small arms and hand grenades ... Unfortunately, the safety device was ...

Methodology for estimating accidental radioactive releases in nuclear waste management

International Nuclear Information System (INIS)

Levy, H.B.

1979-01-01

Estimation of the risks of accidental radioactive releases is necessary in assessing the safety of any nuclear waste management system. The case of a radioactive waste form enclosed in a barrier system is considered. Two test calculations were carried out

Notificación de accidentes y enfermedades laborales al Ministerio de Trabajo. Perú 2010-2014

Directory of Open Access Journals (Sweden)

Christian R Mejia

Full Text Available Con el objetivo de determinar las tendencias de los accidentes y enfermedades laborales notificadas al Ministerio de Trabajo del Perú, se realizó un estudio descriptivo de datos secundarios, con los reportes extraídos de los boletines mensuales desde septiembre de 2010 a diciembre de 2014. Se notificaron a nivel nacional 54 596 accidentes laborales no mortales, las tasas de los accidentes laborales no mortales por millón de habitantes aumentaron en el período 2011- 2013 (296,5 el 2011, 955,9 el 2012 y 1176,3 el 2013, disminuyendo en el 2014 (878,9. Hubieron 674 accidentes mortales, cuyas tasas se incrementaron entre el 2011-2012 y se redujeron entre el 2013-2014. Se reportaron 346 enfermedades laborales, las más frecuentes fueron los casos de hipoacusia (77, enfermedades por posturas inadecuadas (57 y dermatitis alérgica (44; los reportes se redujeron de 6,9 en el 2011 a 2,3 en el 2014. Los reportes de enfermedades laborales fueron disminuyendo, lo que podría indicar una subnotificación importante

Modulation of radiation induced DNA damage by natural products in hemopoietic tissue of mice

International Nuclear Information System (INIS)

Jayakumar, S.; Bhilwade, H.N.; Chaubey, R.C.

2014-01-01

Ionizing radiation is known to induce oxidative stress through generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals, antioxidants or neutraxeuticals which can reduce harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In the present study, we have investigated the radioprotective role of curcumin, a dietary antioxidant, taurine, malabaricone-C, and umbelliferone, for their radioprotective properties in hemopoietic cells of mice. Groups of mice-were fed 1% of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. After the completion of the treatment mice pre-treated with curcumin and taurine were exposed to 3 Gy of gamma rays. Malabaricone-C was tested for its radiomodulation potential in vitro, in spleenocytes of mouse. Spleenocytes were isolated and treated with different concentrations (0.5-25 ìM) of malabaricone-C. Immediately after irradiation, alkaline comet assay were performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus test. Results of these studies showed significant reduction in DNA damage by curcumin. The micronucleus data showed marginal increase in the frequency of micronucleated erythrocytes in curcumin fed group as compared to the controls. Mice receiving curcumin for 3 weeks in diet followed by gamma radiation (3 Gy), showed approximately 50% reduction in the frequency of micro nucleated polychromatic erythrocytes. Pre-treatment of mice with taurine significantly (p < 0.01) reduced the frequency of gamma rays induced mn-PCEs in bone marrow tissue. Malabaricone-C at 1.5 ìM concentration showed very good protection

Decay heat removal and transient analysis in accidental conditions in the EFIT reactor

International Nuclear Information System (INIS)

Bandini, G.; Meloni, P.; Polidori, M.; Casamirra, M.; Castiglia, F.; Giardina, M.

2007-01-01

The development of a conceptual design of an industrial scale transmutation facility (EFIT) of several 100 MW thermal power based on Accelerator Driven System (ADS) is addressed in the frame of the European EUROTRANS Integral Project. In normal operation, the core power of EFIT reactor is removed through steam generators by four secondary loops fed by water. A safety-related Decay Heat Removal (DHR) system provided with four independent inherently safe loops is installed in the primary vessel to remove the decay heat by natural convection circulation under accidental conditions which lead to the Loss of Heat Sink (LOHS). In order to confirm the adequacy of the adopted solution for decay heat removal in accidental conditions, some multi-D analyses have been carried out with the SIMMER-III code. The results of the SIMMER-III code have been then used to support the RELAP5 1-D representation of the natural circulation flow paths in the reactor vessel. Finally, the thermal-hydraulic RELAP5 code has been employed for the analysis of LOHS accidental scenarios. (author)

Investigation of post-accidental management conditions. Complete final report dated July 31, 2009

International Nuclear Information System (INIS)

2009-01-01

After a presentation of the process which resulted in the setting up of an investigation aimed at testing recommendations for post-accidental management, this report indicates the objectives of this investigation: to study the application of recommendations made by the CODIR-PA (Management Committee - Post-Accidental Management) to the operators of the milk sector, and to define an action plan to carry on and resume production. According to the adopted methodology, the study comprised two phases. The first one comprised an analysis of applications in the milk sector, the study of operational consequences on a zoning proposed by the CORDI-PA on the milk sector and on milk products, and the study of the acceptability and feasibility of considered options. The second phase addressed the elaboration of an action plan to carry on and resume the activity. While identifying and assessing the various risks, it identified critical issues for carrying on or resuming milk production in a contaminated territory, and defined an action plan to implement by anticipation or in the post-accidental situation

Study of TSL and OSL properties of dental ceramics for accidental dosimetry applications

International Nuclear Information System (INIS)

Veronese, Ivan; Galli, Anna; Cantone, Marie Claire; Martini, Marco; Vernizzi, Fabrizio; Guzzi, Gianpaolo

2010-01-01

Interest is increasing in the development of new methodologies for accidental dose assessment, exploiting the luminescence and dosimetric properties of objects and materials which can be usually found directly on exposed subjects and/or in the contaminated area. In this work, several types of ceramics employed for dental prosthetics restoration, including both innovative materials used as sub-frames for the construction of the inner part of dental crowns (core), and conventional porcelains used for the fabrication of the external layer (veneer), were investigated with regard to their thermally and optically stimulated luminescence (TSL and OSL respectively) properties, in view of their potential application in accidental dosimetry. The sensitivity to ionizing radiation proved to strongly depend on the type and brand of ceramic, with minimum detectable dose ranging from few mGy up to several tens of mGy. A linear dose-response was observed for most of the samples. However, the luminescence signals were characterised by a significant fading, which has to be taken into account for a reliable accidental dose assessment after a radiation exposure event.

Decay Heat Removal and Transient Analysis in Accidental Conditions in the EFIT Reactor

Directory of Open Access Journals (Sweden)

Giacomino Bandini

2008-01-01

Full Text Available The development of a conceptual design of an industrial-scale transmutation facility (EFIT of several 100 MW thermal power based on accelerator-driven system (ADS is addressed in the frame of the European EUROTRANS Integral Project. In normal operation, the core power of EFIT reactor is removed through steam generators by four secondary loops fed by water. A safety-related decay heat removal (DHR system provided with four independent inherently safe loops is installed in the primary vessel to remove the decay heat by natural convection circulation under accidental conditions which are caused by a loss-of-heat sink (LOHS. In order to confirm the adequacy of the adopted solution for decay heat removal in accidental conditions, some multi-D analyses have been carried out with the SIMMER-III code. The results of the SIMMER-III code have been then used to support the RELAP5 1D representation of the natural circulation flow paths in the reactor vessel. Finally, the thermal-hydraulic RELAP5 code has been employed for the analysis of LOHS accidental scenarios.

A study of foreign object damage (FOD) and prevention method at the airport and aircraft maintenance area

Science.gov (United States)

Hussin, R.; Ismail, N.; Mustapa, S.

2016-10-01

Foreign object damage (FOD) is common risk for aviation industry since long time ago and it has contributed to many terrible incidents and fatalities. The cost of FOD cases every year is very high, which is around RM 1.2 billion. Therefore, a proper technique and strategy has to be taken by the designated organizations including airlines to further eliminate the FOD occurrences. It is not easy to control FOD due to some circumstances such as inappropriate working behaviour, poor working environment, insufficient technology and also disorganized housekeeping system. The main purpose of this research is to discuss and explain further about FOD and the techniques to prevent FOD. FOD is a universal concern in aviation industry and it is one of the reasons that contribute to aircraft failure and unwanted damages such as fatalities and causalities. Throughout this research, many information related to FOD problems and their impact on aviation industry are gathered and presented.

Accidentes de trabajo en el Hospital Clínico de la Universidad de Chile durante el año 2007

Directory of Open Access Journals (Sweden)

Carlos Valdés

2009-01-01

Full Text Available Objetivo, Conocer el número de los accidentes laborales en el Hospital Clínico de la Universidad de Chile (HCUCH el año 2007 y su caracterización de acuerdo a variables como, sexo, edad, tipo de lesión, día de la semana, mes del año, cargo desempeñado y días perdidos. Diseño, Estudio descriptivo, transversal, retrospectivo y observacional. Lugar, Hospital Clínico de la Universidad de Chile (HCUCH. Participantes, Accidentes laborales reportados entre el 1 de Enero y el 31 de Diciembre del 2007. Intervención, Se utilizó la base de datos del Registro de Notificación de Accidentes Laborales, proporcionada por el Departamento de Prevención de Riesgos del HCUCH Principales medidas de Resultados, Porcentajes y Medidas de Tendencia Central, tabuladas en una base de datos con ayuda del programa Microsoft Excel 2003 para Windows ®. Resultados: Se observan 104 accidentes laborales, con un mayor número de eventos en el personal femenino (69,2%, en el rango etareo de 30-39 años (34,3%, el tipo de lesión más frecuente fueron las contusiones/policontusiones (39,4%, el grupo más accidentado fue los auxiliares y técnicos (71.1%. El estudio por días de la semana revela que hay más accidentes los días miércoles y jueves (43,27% y los meses del año con más accidentes fueron enero, agosto y diciembre. La mayor cantidad de accidentes laborales comprometen entre 1 a 5 días perdidos. Conclusiones: Durante el año 2007, se pesquisó 104 accidentes laborales, lo que significó 804 días de ausentismo. Este estudio muestra que el sexo femenino, tener entre 30-39 años y ejercer como auxiliar o técnico fueron factores de asociados al incremento de los accidentes laborales.

Hybrid parallel strategy for the simulation of fast transient accidental situations at reactor scale

International Nuclear Information System (INIS)

Faucher, V.; Galon, P.; Beccantini, A.; Crouzet, F.; Debaud, F.; Gautier, T.

2013-01-01

This contribution is dedicated to the latest methodological developments implemented in the fast transient dynamics software EUROPLEXUS (EPX) to simulate the mechanical response of fully coupled fluid-structure systems to accidental situations to be considered at reactor scale, among which the Loss of Coolant Accident, the Core Disruptive Accident and the Hydrogen Explosion. Time integration is explicit and the search for reference solutions within the safety framework prevents any simplification and approximations in the coupled algorithm: for instance, all kinematic constraints are dealt with using Lagrange Multipliers, yielding a complex flow chart when non-permanent constraints such as unilateral contact or immersed fluid-structure boundaries are considered. The parallel acceleration of the solution process is then achieved through a hybrid approach, based on a weighted domain decomposition for distributed memory computing and the use of the KAAPI library for self-balanced shared memory processing inside sub-domains. (authors)

Análisis de las causas y consecuencias de los accidentes laborales ocurridos en dos proyectos de construcción

Directory of Open Access Journals (Sweden)

A. González

Full Text Available Las labores que se realizan en los proyectos de construcción son consideradas de alto riesgo al facilitar la ocurrencia de accidentes laborales que afectan la integridad física, mental y social de los colaboradores como la productividad de las empresas. Por tal motivo, el propósito de este artículo es analizar las causas y consecuencias de los accidentes laborales ocurridos durante el segundo semestre del año 2012 en dos proyectos de construcción de Neiva, Colombia. El alcance fue de tipo documental considerando como fuente de información los soportes de los accidentes laborales reportados ante la Administradora de Riesgo Laborales (ARL; para determinar las causas que dieron origen a dichos accidentes se utilizó el modelo de Frank E. Bird. Se analizaron 117 accidentes en los que se identificaron 195 faltas de control, 136 factores personales, 112 factores del trabajo, 151 actos inseguros y 54 condiciones inseguras; lo anterior teniendo en cuenta que en algunos accidentes se presentaron más de una causa. De esta manera se concluye que el mayor porcentaje de accidentes de trabajo, ha sido generado por faltas de control seguidos por actos inseguros. Por tal motivo se recomienda la realización de programas de gestión de riesgos prioritarios, basados en una adecuada identificación de peligros, que permitan mitigar y controlar los riesgos, desarrollando a la vez en los trabajadores una cultura de autocuidado

Numerical simulation of industrial and accidental release formation and transport

Energy Technology Data Exchange (ETDEWEB)

Piskunov, V.N.; Aloyan, A.A.; Gerasimov, V.M.; Pinaev, V.S.; Golubev, A.I.; Yanilkin, Yu.V.; Ivanov, N.V.; Nikonov, S.N.; Kharchenko, A.I. [and others

1995-05-01

Statement of work for contract 006 {open_quotes}Mathematical simulation of industrial and accidental release formation and transport{close_quotes} implies that the final result of the activity within this task will be VNIIEF developed techniques which will provide for the prediction of the post-accidental environment. Report [1] presents the description of physical models and calculation techniques which were chosen by VNIIEF to accomplish this task. These techniques were analysed for their capabilities, the areas of their application were defined, modifications within contract 006 were described, the results of test and methodical calculations were presented. Moreover, the experimental data were analysed over the source parameters and contamination measurements which can be used in the comparison with the calculation results. Based an these data this report compares the calculation results obtained with VNIIEF calculation techniques with the LANL-presented experimental results. The calculations which statements and results are given in section 1, included the following processes: explosion cloud ascent dynamics and jet release origin; aerosols kinetics in the release source including composite particle origin in the explosion cloud caused by radioactive substance sorption an the soil particles; contaminant transport in atmosphere and their in-site fallout due to the accidental explosions and fires; atmospheric flow dynamics and industrial contamination transfer over the complicated terrain. The calculated results were compared with the experimental data. Section 2 presents the parameters for a typical source in the explosion accidents based an the experimental results and calculated data from Section 1, as well as contamination patterns were calculated with basic technique {open_quotes}Prognosis{close_quotes}.

Evaluation of accidental coincidences for time-differential Moessbauer-spectroscopy

International Nuclear Information System (INIS)

Alflen, M.; Meyer, W.

1995-01-01

The accidental coincidences of a measuring system based on time-to-amplitude conversion are considered in some detail for the case of low starting and high stopping rates. Two types of accidental coincidences are distinguished, those carrying time information and those without time information. Neglecting any deadtime effects of the detectors, analytical expressions for the calculation of the time distribution of the random coincidences are evaluated. The analytical expressions have been confirmed by Monte Carlo simulations. The procedure is applied to time-differential Moessbauer spectroscopy in order to extract the time spectra of true coincidences. The measured spectrum in a time channel turns out to be a superposition of the true spectrum (true coincidences), a time integral spectrum (random coincidences), and a weighted superposition of true spectra of other time channels (random but time carrying information). A measurement with a single line 57 Co/Rh-source and single line K[Fe(CN) 6 ].3H 2 O-absorber with stopping rates of 1 MBq shows agreement between the theoretical time-filtered spectra and the corrected measured spectra of true coincidences. ((orig.))

Concrete model for finite element analysis of structures subjected to severe damages

International Nuclear Information System (INIS)

Jamet, Ph.; Millard, A.; Hoffmann, A.; Nahas, G.; Barbe, B.

1984-01-01

A specific concrete model has been developed, in order to perform mechanical analysis of civil engineering structures, when subjected to accidental loadings, leading to severe damages. Its formulation is based on the physical mechanisms, which have been observed on laboratory specimens. The model has been implemented into the CASTEM finite element system, and the case of a concrete slab perforation by a rigid missile has been considered. The qualitative behaviour of the structure is well predicted by the model. Comparison between numerical and experimental results is also performed, using two main curves: missile velocity versus penetration depth; reaction forces versus time. (Author) [pt

A tree branch instead of a ligature: an unusual accidental hanging.

Science.gov (United States)

Vadysinghe, Amal Nishantha; Sivasubramanium, Murugupillai; Jayasooriya, Rankothge Pemasiri

2017-12-01

A unique case of accidental hanging due to compression of the neck of an adult by the branches of a coffee tree is reported. The decedent was a 42-year-old male who was found dead in a semi prone position on a slope. His neck was lodged in a wedge formed by two branches of a coffee tree, with his legs angled downwards on the slope. Autopsy revealed two friction abrasions located horizontally on either side of the front of the neck, just above the larynx. The findings were compatible with compression of the neck by the branches of the tree, with the body weight of the decedent contributing to compression. Subsequent complete autopsy examination confirmed the cause of death as hanging. Following an inquest the death was ruled to be accidental.

Prevention of Noise Damage to Cochlear Synapses

Science.gov (United States)

2017-10-01

Assessment of synapse regeneration : Twelve week old CBA/CaJ mice are exposed to a moderate noise that destroys synapses on inner hair cells (IHCs) but spares...result of excitotoxic trauma to cochlear synapses due to glutamate released from the hair cells . Excitotoxic trauma damages the postsynaptic cell by...components ............................................. 12 d) Quantitative analysis of effects of neurotrophic factors on synapse regeneration in vitro

Activated protein C and its potential applications in prevention of islet β-cell damage and diabetes.

Science.gov (United States)

Xue, Meilang; Jackson, Christopher J

2014-01-01

Activated protein C (APC) is derived from its precursor, protein C (PC). Originally thought to be synthesized exclusively by the liver, recent reports have shown that PC is also produced by many other cells including pancreatic islet β cells. APC functions as a physiological anticoagulant with anti-inflammatory, anti-apoptotic, and barrier-stabilizing properties. APC exerts its protective effects via an intriguing mechanism requiring combinations of endothelial PC receptor, protease-activated receptors, epidermal growth factor receptor, Tie2 or CD11b, depending on cell types. Diabetes is a chronic condition resulted from the body's inability to produce and/or properly use insulin. The prevalence of diabetes has risen dramatically and has become one of the major causes of premature mortality and morbidity worldwide. Diabetes prevention is an ideal approach to reduce this burden. Type 1 and type 2 diabetes are the major forms of diabetes mellitus, and both are characterized by an autoimmune response, intraislet inflammation, β-cell apoptosis, and progressive β-cell loss. Protecting β-cell from damage is critical in both prevention and treatment of diabetes. Recent in vitro and animal studies show that APC's strong anti-inflammatory and anti-apoptotic properties are beneficial in preventing β-cell destruction and diabetes in the NOD mouse model of type 1 diabetes. Future preventive and therapeutic uses of APC in diabetes look very promising. © 2014 Elsevier Inc. All rights reserved.

Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis

Science.gov (United States)

Caputo, Fanny; de Nicola, Milena; Sienkiewicz, Andrzej; Giovanetti, Anna; Bejarano, Ignacio; Licoccia, Silvia; Traversa, Enrico; Ghibelli, Lina

2015-09-01

Efficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic effects on cells. Therefore, improvements in cosmetic solar shield technology are a strong priority. CeO2 nanoparticles are not only UV refractors but also potent biological antioxidants due to the surface 3+/4+ valency switch, which confers anti-inflammatory, anti-ageing and therapeutic properties. Herein, UV irradiation protocols were set up, allowing selective study of the extra-shielding effects of CeO2vs. TiO2 nanoparticles on reporter cells. TiO2 irradiated with UV (especially UVA) exerted strong photocatalytic effects, superimposing their pro-oxidant, cell-damaging and mutagenic action when induced by UV, thereby worsening the UV toxicity. On the contrary, irradiated CeO2 nanoparticles, via their Ce3+/Ce4+ redox couple, exerted impressive protection on UV-treated cells, by buffering oxidation, preserving viability and proliferation, reducing DNA damage and accelerating repair; strikingly, they almost eliminated mutagenesis, thus acting as an important tool to prevent skin cancer. Interestingly, CeO2 nanoparticles also protect cells from the damage induced by irradiated TiO2, suggesting that these two particles may also complement their effects in solar lotions. CeO2 nanoparticles, which intrinsically couple UV shielding with biological and genetic protection, appear to be ideal candidates for next-generation sun shields.

A national survey (NAP5-Ireland baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in Ireland.

LENUS (Irish Health Repository)

Jonker, W R

2014-06-29

As part of the 5th National Audit Project of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland concerning accidental awareness during general anaesthesia, we issued a questionnaire to every consultant anaesthetist in each of 46 public hospitals in Ireland, represented by 41 local co-ordinators. The survey ascertained the number of new cases of accidental awareness becoming known to them for patients under their care or supervision for a calendar year, as well as their career experience. Consultants from all hospitals responded, with an individual response rate of 87% (299 anaesthetists). There were eight new cases of accidental awareness that became known to consultants in 2011; an estimated incidence of 1:23 366. Two out of the eight cases (25%) occurred at or after induction of anaesthesia, but before surgery; four cases (50%) occurred during surgery; and two cases (25%) occurred after surgery was complete, but before full emergence. Four cases were associated with pain or distress (50%), one after an experience at induction and three after experiences during surgery. There were no formal complaints or legal actions that arose in 2011 related to awareness. Depth of anaesthesia monitoring was reported to be available in 33 (80%) departments, and was used by 184 consultants (62%), 18 (6%) routinely. None of the 46 hospitals had a policy to prevent or manage awareness. Similar to the results of a larger survey in the UK, the disparity between the incidence of awareness as known to anaesthetists and that reported in trials warrants explanation. Compared with UK practice, there appears to be greater use of depth of anaesthesia monitoring in Ireland, although this is still infrequent.

Accidental fatal lung injury by compressed air: a case report.

Science.gov (United States)

Rayamane, Anand Parashuram; Pradeepkumar, M V

2015-03-01

Compressed air is being used extensively as a source of energy at industries and in daily life. A variety of fatal injuries are caused by improper and ignorant use of compressed air equipments. Many types of injuries due to compressed air are reported in the literature such as colorectal injury, orbital injury, surgical emphysema, and so on. Most of these injuries are accidental in nature. It is documented that 40 pounds per square inch pressure causes fatal injuries to the ear, eyes, lungs, stomach, and intestine. Openings of body are vulnerable to injuries by compressed air. Death due to compressed air injuries is rarely reported. Many cases are treated successfully by conservative or surgical management. Extensive survey of literature revealed no reports of fatal injury to the upper respiratory tract and lungs caused by compressed air. Here, we are reporting a fatal event of accidental death after insertion of compressed air pipe into the mouth. The postmortem findings are corroborated with the history and discussed in detail.

Enfermedad preexistente, agravamiento y/o accidente de trabajo: análisis de 10 casos clínicos

Directory of Open Access Journals (Sweden)

Ana M.ª González Onetti

2014-01-01

Full Text Available En nuestro centro asistencial se han atendido en el año 2012, 1.304 primeras asistencias, de las cuales 85 fueron consideradas no accidente de trabajo/enfermedad profesional. Hemos elegido al azar 10 casos clínicos donde existió discrepancia por parte del paciente cuando los servicios médicos determinaron que la patología que sufría el paciente no era accidente de trabajo y/o agravamiento por lo que se derivó a su médico de atención primaria quien emitió parte de baja por contingencias comunes y se inició determinación de contingencias ante el INSS por parte del Servicio Andaluz de Salud. En 7 de los casos existió discrepancia entre los inspectores médicos del INSS y los servicios médicos de la mutua, en 3 de ellos se consideraron enfermedad común al existir enfermedad preexistente. De los casos analizados comprobamos que no existían criterios unificados, claros y precisos entre enfermedad preexistente, agravamiento y/o accidente de trabajo dependiendo del médico evaluador y/o médico de la mutua determinar si era o no accidente de trabajo. Si no existían antecedentes médicos por el SAS y/o bajas previas por ITCC por la misma patología o similar el INSS determino siempre la contingencia como accidente de trabajo. El tiempo medio de los 10 casos analizados entre el inicio de la determinación de contingencias y la comunicación de la resolución por parte del INSS fue de 240 días. De los 7 casos que fueron accidente de trabajo, 6 seguían en situación de baja laboral y un caso se encontraba curado e incorporado a su puesto de trabajo.

Prevention and management of accidental foreign body ingestion and aspiration in orthodontic practice

Directory of Open Access Journals (Sweden)

Umesan UK

2012-05-01

Full Text Available Uday Kumar Umesan,1 Kui Lay Chua,1 Priya Balakrishnan21National Dental Centre, 2Kg Kiarong, Bandar Seri Begawan, Brunei DarussalamAbstract: Among the myriad emergencies that could arise in the dental clinical setting there are a few that occur occasionally despite being entirely preventable. Ingestion or aspiration of dental materials, appliances, or instruments comprises this category. Regardless of incidence, foreign body ingestion or aspiration episodes are recognized as potential complications in the specialty of orthodontics. Despite their infrequent occurrence, the morbidity from a single incident and the amount of specialty medical care that may be needed to manage such incidents is too high to ignore. There is also the associated risk of malpractice litigation given the fact that these incidents are preventable. At present, no clear guidelines exist regarding prevention of this emergency in practice. This article attempts to review relevant literature and aims to formulate certain recommendations based on best available evidence to minimize the incidence of such events, while also suggesting guidelines toward making their management more effective. A flow chart outlining management options and strategies to aid the clinician in the event of such an emergency is also presented.Keywords: foreign bodies, ingestion, orthodontics, respiratory aspiration, orthodontic appliances

Concept of radiological, medical and social protection of the population of Russia affected by accidental exposure

International Nuclear Information System (INIS)

Osechinski, I.V.; Ivanov, E.V.; Ramzaev, P.V.; Balonov, M.I.; Tsyb, A.F.

1997-01-01

Main principles of population radiation protection from various accidental exposure, including the Chernobyl accident, have been implemented in officially approved Concept ''On radiological, medical, social protection and rehabilitation of the Russian Federation population affected by accidental radiation exposure''. The concept includes basic principles of radiation protection, designation of regional radionuclide contaminated territories, records and registers of exposed persons, health protection and rehabilitation, socio-economic and legal aspects

Accidental degeneracy in photonic bands and topological phase transitions in two-dimensional core-shell dielectric photonic crystals.

Science.gov (United States)

Xu, Lin; Wang, Hai-Xiao; Xu, Ya-Dong; Chen, Huan-Yang; Jiang, Jian-Hua

2016-08-08

A simple core-shell two-dimensional photonic crystal is studied where the triangular lattice symmetry and the C6 point group symmetry give rich physics in accidental touching points of photonic bands. We systematically evaluate different types of accidental nodal points at the Brillouin zone center for transverse-magnetic harmonic modes when the geometry and permittivity of the core-shell material are continuously tuned. The accidental nodal points can have different dispersions and topological properties (i.e., Berry phases). These accidental nodal points can be the critical states lying between a topological phase and a normal phase of the photonic crystal. They are thus very important for the study of topological photonic states. We show that, without breaking time-reversal symmetry, by tuning the geometry of the core-shell material, a phase transition into the photonic quantum spin Hall insulator can be achieved. Here the "spin" is defined as the orbital angular momentum of a photon. We study the topological phase transition as well as the properties of the edge and bulk states and their application potentials in optics.

Cuidado popular de familias con un adulto mayor sobreviviente del primer accidente cerebrovascular

Directory of Open Access Journals (Sweden)

Lucero López-Díaz

2016-01-01

Full Text Available Introducción: el accidente cerebrovascular afecta a numerosas personas en el mundo y se constituye en la principal causa de muer- te. Los sobrevivientes pueden padecer discapacidad y sufrir modificaciones en las actividades cotidianas. La familia es el principal apoyo del sobreviviente y al ser parte de una misma cultura, construye acciones de cuidado en búsqueda del bienestar. Objetivo: describir las acciones del cuidado popular de las familias con un adulto mayor sobreviviente del primer accidente cerebrovascular. Método: estudio etnográfico, con observación participante y entrevistas en profundidad. Participaron siete familias bogotanas (siete adultos mayores entre los dos y diez meses posteriores al primer accidente cerebrovascular y los siete cuidadores principales respectivos. Resultados: cuidadores y adulto mayor comparten acciones de cuidado para la recuperación, relacionadas con la alimentación, el cuidado personal y la ingesta de medicamentos permeadas por la creencia religiosa, fuente de soporte y vínculo afectivo. Conclusión: conocer el cuidado popular de esta población posibilita proponer acciones culturalmente congruentes con sus valores y creencias para potencializar las ca- pacidades familiares e intermediar en los procesos de tratamiento.

Corrections for the effects of accidental coincidences, Compton scatter, and object size in positron emission mammography (PEM) imaging

Science.gov (United States)

Raylman, R. R.; Majewski, S.; Wojcik, R.; Weisenberger, A. G.; Kross, B.; Popov, V.

2001-06-01

Positron emission mammography (PEM) has begun to show promise as an effective method for the detection of breast lesions. Due to its utilization of tumor-avid radiopharmaceuticals labeled with positron-emitting radionuclides, this technique may be especially useful in imaging of women with radiodense or fibrocystic breasts. While the use of these radiotracers affords PEM unique capabilities, it also introduces some limitations. Specifically, acceptance of accidental and Compton-scattered coincidence events can decrease lesion detectability. The authors studied the effect of accidental coincidence events on PEM images produced by the presence of /sup 18/F-Fluorodeoxyglucose in the organs of a subject using an anthropomorphic phantom. A delayed-coincidence technique was tested as a method for correcting PEM images for the occurrence of accidental events. Also, a Compton scatter correction algorithm designed specifically for PEM was developed and tested using a compressed breast phantom. Finally, the effect of object size on image counts and a correction for this effect were explored. The imager used in this study consisted of two PEM detector heads mounted 20 cm apart on a Lorad biopsy apparatus. The results demonstrated that a majority of the accidental coincidence events (/spl sim/80%) detected by this system were produced by radiotracer uptake in the adipose and muscle tissue of the torso. The presence of accidental coincidence events was shown to reduce lesion detectability. Much of this effect was eliminated by correction of the images utilizing estimates of accidental-coincidence contamination acquired with delayed coincidence circuitry built into the PEM system. The Compton scatter fraction for this system was /spl sim/14%. Utilization of a new scatter correction algorithm reduced the scatter fraction to /spl sim/1.5%. Finally, reduction of count recovery due to object size was measured and a correction to the data applied. Application of correction techniques

Accidental Outcomes Guide Punishment in a “Trembling Hand” Game

Science.gov (United States)

Cushman, Fiery; Dreber, Anna; Wang, Ying; Costa, Jay

2009-01-01

How do people respond to others' accidental behaviors? Reward and punishment for an accident might depend on the actor's intentions, or instead on the unintended outcomes she brings about. Yet, existing paradigms in experimental economics do not include the possibility of accidental monetary allocations. We explore the balance of outcomes and intentions in a two-player economic game where monetary allocations are made with a “trembling hand”: that is, intentions and outcomes are sometimes mismatched. Player 1 allocates $10 between herself and Player 2 by rolling one of three dice. One die has a high probability of a selfish outcome, another has a high probability of a fair outcome, and the third has a high probability of a generous outcome. Based on Player 1's choice of die, Player 2 can infer her intentions. However, any of the three die can yield any of the three possible outcomes. Player 2 is given the opportunity to respond to Player 1's allocation by adding to or subtracting from Player 1's payoff. We find that Player 2's responses are influenced substantially by the accidental outcome of Player 1's roll of the die. Comparison to control conditions suggests that in contexts where the allocation is at least partially under the control of Player 1, Player 2 will punish Player 1 accountable for unintentional negative outcomes. In addition, Player 2's responses are influenced by Player 1's intention. However, Player 2 tends to modulate his responses substantially more for selfish intentions than for generous intentions. This novel economic game provides new insight into the psychological mechanisms underlying social preferences for fairness and retribution. PMID:19707578

Geriatric falls: prevention strategies for the staff.

Science.gov (United States)

Brady, R; Chester, F R; Pierce, L L; Salter, J P; Schreck, S; Radziewicz, R

1993-09-01

1. Multiple falls and injuries are more prevalent among elderly over the age of 75 and are the second leading cause of accidental death in the elderly. The risk for falling is noted to be significantly greater in the hospitalized elderly. 2. Review of retrospective quality improvement chart audits revealed that peak fall times were associated with the patient's need for toileting, rest, and obtaining nutrition and hydration. 3. The MetroHealth Falls Prevention Program is based on simple proactive measures to prevent falls in the elderly. 4. An effective falls prevention program has several implications for gerontological nursing practice, including less restraint use, increased patient autonomy, and decreased loss of self-esteem. There is also a sense of increased nursing control over patient safety and time management, as well as implications for further nursing research.

The new definition of nuclear damage in the 1997 protocol to amend the 1963 vienna convention on civil liability for nuclear damage

International Nuclear Information System (INIS)

Soljan, V.

2000-01-01

This communication analyzes the content and the impact of the new definition of nuclear damage contented in the amendment protocol of the Vienna Convention relative to the civil liability in the 1963 Convention. Having in mind the experience of the Three Mile Island and Chernobyl accidents, it is demonstrated that the costs of preventive measures, damage to the environment and economic loss may constitute substantial portions of the total damage following a nuclear accident. Then, the new definition is studied in detail, on insisting on the notion of economic loss. A development is devoted to the question of damage to the environment. The preventive measures are studied and their conditions of the compensation receivability evoked with the criteria of reasonable measures. (N.C.)

Accidental administration of Syntometrine in adult dosage to the newborn.

OpenAIRE

Whitfield, M F; Salfield, S A

1980-01-01

The clinical course is described of an infant who accidentally received an adult dose of Syntometrine (synthetic oxytocin + ergometrine) at delivery. The infant soon became ill with convulsions and ventilatory failure, and later with water intoxication. Similar reported cases are reviewed and recommendations are given for the management of future cases.

Accidentes percutáneos con riesgo biológico, producidos por dispositivos de seguridad en la Comunidad de Madrid Percutaneous injuries with biological risk caused by security devices in Madrid Community

Directory of Open Access Journals (Sweden)

María Clemente Yélamos

2012-06-01

Full Text Available Desde la implantación en 2006, de procedimientos seguros y un Sistema de Vigilancia de Accidentes Biológicos en el ámbito sanitario de la Comunidad de Madrid, se viene observando un aumento de los accidentes percutáneos relacionados con la utilización de Dispositivos de Seguridad. Con la finalidad de estudiar los factores contribuyentes a la producción de accidentes con estos nuevos dispositivos, se realiza un estudio descriptivo longitudinal prospectivo de los accidentes notificados a lo largo de 6 meses (2010-2011. Se incluyen 378 accidentes, el 86% afectó a mujeres, siendo la tasa de incidencia en enfermería de 14,3 y entre facultativos de 3,1 (accidentes por mil. Las agujas subcutáneas fueron las más implicadas (25,7%. En el 6,6% de los accidentes se había inactivado intencionadamente su mecanismo de seguridad y solo un 2,6% podría imputarse a un fallo del dispositivo. Entre los factores externos que han podido contribuir destacan "apremio de tiempo/ritmo de trabajo elevado" (46,5% y "realizar la maniobra con posturas incómodas" (31,5%. Las intervenciones para prevenir Accidentes Biológicos deben ser específicas para cada categoría profesional y área de trabajo. Se debe seguir apostando por la introducción de Dispositivos de Seguridad, identificar los factores contribuyentes e implementar acciones individualizadas que minimicen los riesgos.Since the implementation in 2006 of security procedures and a surveillance system of biological accidents in Madrid public health services, an increase of percutaneus accidents related to the use of safety devices has been observed. With the purpose of studying the external factors to the production of accidents with these new devices, there is realized a prospective, longitudinal and descriptive study of the accidents happened throughout six months (2010-2011. 378 accidents are included, 86% happened in women, the incidence rate being 14.3 accidents per thousand in nurses, and 3.1 in

Accidental Coverage of Both Renal Arteries during Infrarenal Aortic Stent-Graft Implantation: Cause and Treatment

Directory of Open Access Journals (Sweden)

Umberto Marcello Bracale

2014-01-01

Full Text Available The purpose of this paper is to report a salvage maneuver for accidental coverage of both renal arteries during endovascular aneurysm repair (EVAR of an infrarenal abdominal aortic aneurysm (AAA. A 72-year-old female with a 6 cm infrarenal abdominal aortic aneurysm was treated by endovascular means with a standard bifurcated graft. Upon completing an angiogram, both renal arteries were found to be accidentally occluded. Through a left percutaneous brachial approach, the right renal artery was catheterized and a chimney stent was deployed; however this was not possible for the left renal artery. A retroperitoneal surgical approach was therefore carried out with a retrograde chimney stent implanted to restore blood flow. After three months, both renal arteries were patent and renal function was not different from the baseline. Both endovascular with percutaneous access via the brachial artery and open retroperitoneal approaches with retrograde catheterization are feasible rescue techniques to recanalize the accidentally occluded renal arteries during EVAR.

Optimal conditions in (/sup 3/H)-thymidine uptake studies to prevent radiation damage to cells. A scintimetric and cytofluorographic analysis

Energy Technology Data Exchange (ETDEWEB)

Ruiz-Arguelles, A; Llorente, L; Diaz-Jouanen, E; Alarcon-Segovia, D [Instituto Nacional de la Nutricion, Mexico City

1981-12-01

Cells subjected to nucleoside incorporation studies using radiolabelled materials may suffer radiation damage that can alter the results. Scintimetric and cytofluorographic analyses were performed to confirm this and to determine the optimal experimental doses of, and exposure times to, (/sup 3/H)-TdR, in order to prevent or minimize such radiation damage to cells. The results showed that cultures of human mononuclear cells should be pulsed with 0.125 ..mu..Ci for 14 hr when stimulated with phytohaemagglutinin, 0.125 ..mu..Ci for 18 hr when stimulated with pokeweed mitogen, 0.5 ..mu..Ci for 8 hr when stimulated with concanavalin A and 0.5 ..mu..Ci for 8 hr when subjected to allogeneic stimulus, in order to achieve optimal incorporation with minimal disturbances of the cell cycle.

Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis

KAUST Repository

Caputo, Fanny

2015-08-20

Efficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic effects on cells. Therefore, improvements in cosmetic solar shield technology are a strong priority. CeO2 nanoparticles are not only UV refractors but also potent biological antioxidants due to the surface 3+/4+ valency switch, which confers anti-inflammatory, anti-ageing and therapeutic properties. Herein, UV irradiation protocols were set up, allowing selective study of the extra-shielding effects of CeO2vs. TiO2 nanoparticles on reporter cells. TiO2 irradiated with UV (especially UVA) exerted strong photocatalytic effects, superimposing their pro-oxidant, cell-damaging and mutagenic action when induced by UV, thereby worsening the UV toxicity. On the contrary, irradiated CeO2 nanoparticles, via their Ce3+/Ce4+ redox couple, exerted impressive protection on UV-treated cells, by buffering oxidation, preserving viability and proliferation, reducing DNA damage and accelerating repair; strikingly, they almost eliminated mutagenesis, thus acting as an important tool to prevent skin cancer. Interestingly, CeO2 nanoparticles also protect cells from the damage induced by irradiated TiO2, suggesting that these two particles may also complement their effects in solar lotions. CeO2 nanoparticles, which intrinsically couple UV shielding with biological and genetic protection, appear to be ideal candidates for next-generation sun shields. © The Royal Society of Chemistry 2015.

Analyses of postulated accidental releases of UF6 inside process buildings

International Nuclear Information System (INIS)

Oliveira Neto, Jose Messias de; Nunes, Beatriz Guimaraes; Dias, Cristiane

2009-01-01

Uranium Hexafluoride is a material used in the various processes which comprise the front end of the nuclear fuel cycle (conversion, enrichment and fuel fabrication). Confinement of UF 6 is a very important safety requirement since this material is highly reactive and presents safety hazards to humans. The present paper discusses the safety relevant aspects of accidental releases of UF 6 inside process confinement buildings. Postulated accidental scenarios are analyzed and their consequences evaluated. Implant releases rates are estimated using computer code predictions. A time dependent homogeneous compartment model is used to predict concentrations of UF 6 , hydrogen fluoride and uranyl fluoride inside a confinement building, as well as to evaluate source terms released to the atmosphere. These source terms can be used as input to atmospheric dispersion models to evaluate consequences to the environment. The results can also be used to define adequate protective measures for emergency situations. (author)

Clinical Profile of Acute Accidental Poisoning Among Children- A Retrospective Study

Directory of Open Access Journals (Sweden)

Tabassum Khatoon

2017-12-01

Full Text Available Acute toxicity is a frequent but avoidable cause of morbidity and mortality in children especially in developing countries, including India. Present study assesses their pattern with relation to different age groupings. This retrospective study was conducted among all hospitalised paediatric victims of acute accidental poisoning at the King George Medical University; Lucknow during 2010 -11. Their history, baseline characteristics, clinical course and outcome was studied. Most children were male of less than three years with 4% overall mortality. Kerosene oil was implicated in most cases. Childhood poisoning is commonest during 1-3 years with a male preponderance. Household poisons; especially kerosene oil was responsible for most cases which was consumed accidentally. Parents must be educated and warned to keep these toxic ingredients safely in suitable containers and out of reach of their beloved children. Keywords: Forensic Science, Paediatric, Acute Poisoning, Kerosene, Outcome.

Multi-physics modeling of multifunctional composite materials for damage detection

Science.gov (United States)

Sujidkul, Thanyawalai

This study presents a modeling of multifunction composite materials for damage detection with its verification and validation to mechanical behavior predictions of Carbon Fibre Reinforced Polymer composites (CFRPs), CFRPs laminated composites, and woven SiC/SiC matrix composites that are subjected to fracture damage. Advantages of those materials are low cost, low density, high strength-to-weight ratio, and comparable specific tensile properties, the special of SiC/SiC is good environmental stability at high temperature. Resulting in, the composite has been used for many important structures such as helicopter rotors, aerojet engines, gas turbines, hot control surfaces, sporting goods, and windmill blades. Damage or material defect detection in a mechanical component can provide vital information for the prediction of remaining useful life, which will result in the prevention of catastrophic failures. Thus the understanding of the mechanical behavior have been challenge to the prevent damage and failure of composites in different scales. The damage detection methods in composites have been investigated widely in recent years. Non-destructive techniques are the traditional methods to detect the damage such as X-ray, acoustic emission and thermography. However, due to the invisible damage in composite can be occurred, to prevent the failure in composites. The developments of damage detection methods have been considered. Due to carbon fibers are conductive materials, in resulting CFRPs can be self-sensing to detect damage. As is well known, the electrical resistance has been shown to be a sensitive measure of internal damage, and also this work study in thermal resistance can detect damage in composites. However, there is a few number of different micromechanical modeling schemes has been proposed in the published literature for various types of composites. This works will provide with a numerical, analytical, and theoretical failure models in different damages to

Accidental intoxication of the infant-juvenile population in households: profiles of emergency care

Directory of Open Access Journals (Sweden)

Jackeline Gonçalves Brito

Full Text Available OBJECTIVE Analyzing profiles of intoxication and accidental poisoning of infant-juvenile population (0-24 years in the household, treated at a reference facility for Emergency and Primary Care, during the year 2013. METHOD A descriptive, cross-sectional study. Data were analyzed using Epi-Info, by way of simple and bivariate analyzes. The project was approved by the Research Ethics Committee (protocol 405.578. RESULTS There were 45 intoxications, with a prevalence of males (60.0%, aged 1-4 years (71.1%. Among children under one, there was a higher frequency of pesticide poisoning (66.6%, between the ages of 1-4 by cleaning products (34.4%, and between 5-9 years of age by pharmacological substances (66.6%. The primary assistance was provided only at health institutions, with hospital admissions in 24.4% of the cases. CONCLUSION The importance of prevention through legislation is evident, in order to ensure greater safety in packaging of various products, and community awareness to eliminate risks in the household environment.

Use of lectin-induced lymphocyte stimulation as a biodosimeter of radiation damage

International Nuclear Information System (INIS)

Shifrine, M.; Taylor, N.J.; DeRock, E.W.; Wiger, N.; Wilson, F.D.

1979-01-01

The purpose of this study was to determine the feasibility of utilizing an in vitro test to determine whether an individual has suffered radiation damage. It was not our purpose to develop a test capable of detecting low doses but rather to determine possible damage due to a radiation accident at medium to high doses. In a pilot study using the whole blood lymphocyte stimulation test (WB/LST), we pretested six dogs weekly for three weeks. One was sham irradiated and is referred to as the control and one each received an acute whole body dose of 10, 25, 50, 75, or 100 R. The dogs were tested one day post-irradiation and then weekly for 56 days. Our data indicate that, using Con-A and PHA in the WB/LST, a biodosimeter can be developed to determine recovery of lymphocyte function after suspected radiation exposure to confirm accidental radiation and estimate the magnitude of the dose

A new analysis of radiation-induced cytogenetic damage in human lymphocytes using the PCC technique, and its implications for biological dosimetry and the understanding of cell-cycle-dependent radiosensitivity fluctuations

International Nuclear Information System (INIS)

Zannos, A.; Pantelias, G.E.

1993-01-01

The objectives of the project are: to develop a sensitive biological dosemeter, based on the analysis of C-banded peripheral blood lymphocyte prematurely condensed chromosomes (PCCs), for the early assessment of radiation injury and the establishment of absorbed dose estimates in accidental overexposures; and to elucidate the mechanisms of radiation action at the molecular, chromosomal and cellular levels by the study of the effects of DNA repair inhibitors on the repair of radiation damage, effects of BrdUrd incorporation on radiation damage, effects of hyperthermia on the induction and repair of radiation-induced damage, and induction and repair of radiation damage in an X-ray sensitive CHO mutant cell line. (authors) 16 refs., 1 fig

Simulation and Damage Analysis of an Accidental Jet Fire in a High-Pressure Compressed Pump Shelter

OpenAIRE

Jang, Chang Bong; Choi, Sang-Won

2016-01-01

Background: As one of the most frequently occurring accidents in a chemical plant, a fire accident may occur at any place where transfer or handling of combustible materials is routinely performed. Methods: In particular, a jet fire incident in a chemical plant operated under high pressure may bring severe damage. To review this event numerically, Computational Fluid Dynamics methodology was used to simulate a jet fire at a pipe of a compressor under high pressure. Results: For jet fire...

TWO-DIMENSIONAL MODELLING OF ACCIDENTAL FLOOD WAVES PROPAGATION

OpenAIRE

Lorand Catalin STOENESCU

2011-01-01

The study presented in this article describes a modern modeling methodology of the propagation of accidental flood waves in case a dam break; this methodology is applied in Romania for the first time for the pilot project „Breaking scenarios of Poiana Uzului dam”. The calculation programs used help us obtain a bidimensional calculation (2D) of the propagation of flood waves, taking into consideration the diminishing of the flood wave on a normal direction to the main direction; this diminishi...

Steering committee for the management of the post-accidental phase of a nuclear accident or of a radiological situation (CODIRPA). Work group nr 8 'Communication' - 2011 January 10. Synthesis of the report of the 'nuclear post-accidental communication' nr 8 work group

International Nuclear Information System (INIS)

Delmestre, Alain; Bouchot, Emmanuel; Mehl-Auget, Isabelle; Theron, Francois; Attiach, Alexandra; Leurette, Marc; Villeneuve, Marcel; Volant, Philippe; Bigot, Marie-Pierre; Demet, Michel; Lheureux, Yves; Herve, Christophe

2011-01-01

A first part of this report addresses the State communication in a nuclear post-accidental situation, and notably discusses and comments the necessity to communicate during the post-accidental phase, how communication should be organised, and which are the main objectives of the State communication during a post-accidental phase. The second part addresses the State operational communication in a nuclear post-accidental situation. It defines its addressees (population, institutional actors, associations and opinion relays), proposes recommendations for a prescriptive communication (conditions for efficiency, required conditions, lessons learned from the Chernobyl accident), and makes recommendations about the relationships with media. Some good practices of communication tools are also identified. The third part contains communication operational tools such as language elements and practical advices for the different stages and aspects of communication

IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage.

Science.gov (United States)

Vicetti Miguel, Rodolfo D; Quispe Calla, Nirk E; Dixon, Darlene; Foster, Robert A; Gambotto, Andrea; Pavelko, Stephen D; Hall-Stoodley, Luanne; Cherpes, Thomas L

2017-08-15

Genital Chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (UGT) damage. Consistent with this presentation, type 2 innate and T H 2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the UGT of Chlamydia -infected women. Primary C. trachomatis infection of mice also causes no genital pathology, but unlike women, does not generate Chlamydia -specific T H 2 immunity. Herein, we explored the significance of type 2 innate immunity for restricting UGT tissue damage in Chlamydia -infected mice, and in initial studies intravaginally infected wild-type, IL-10 -/- , IL-4 -/- , and IL-4Rα -/- mice with low-dose C. trachomatis inoculums. Whereas Chlamydia was comparably cleared in all groups, IL-4 -/- and IL-4Rα -/- mice displayed endometrial damage not seen in wild-type or IL-10 -/- mice. Congruent with the aberrant tissue repair in mice with deficient IL-4 signaling, we found that IL-4Rα and STAT6 signaling mediated IL-4-induced endometrial stromal cell (ESC) proliferation ex vivo, and that genital administration of an IL-4-expressing adenoviral vector greatly increased in vivo ESC proliferation. Studies with IL-4-IRES-eGFP (4get) reporter mice showed eosinophils were the main IL-4-producing endometrial leukocyte (constitutively and during Chlamydia infection), whereas studies with eosinophil-deficient mice identified this innate immune cell as essential for endometrial repair during Chlamydia infection. Together, our studies reveal IL-4-producing eosinophils stimulate ESC proliferation and prevent Chlamydia -induced endometrial damage. Based on these results, it seems possible that the robust type 2 immunity elicited by Chlamydia infection of human genital tissue may analogously promote repair processes that reduce phenotypic disease expression.

Coincidence counting corrections for dead time losses and accidental coincidences

International Nuclear Information System (INIS)

Wyllie, H.A.

1987-04-01

An equation is derived for the calculation of the radioactivity of a source from the results of coincidence counting taking into account the dead-time losses and accidental coincidences. The derivation is an extension of the method of J. Bryant [Int. J. Appl. Radiat. Isot., 14:143, 1963]. The improvement on Bryant's formula has been verified by experiment

In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse

International Nuclear Information System (INIS)

Jayakumar, S.; Bhilwade, H.N.; Chaubey, R.C.

2012-01-01

Ionizing radiation is known to produce oxidative stress through the generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals or other naturally occurring compounds which can reduce the harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In present study, we have investigated the protective role of curcumin, taurine, apigenin and kaempferol against radiation-induced oxidative damage in mice. Groups of mice were fed 1 % of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. Other four groups of mice were injected i.p. with apigenin (10.8 mg/kg BW and 21.6 mg/kg BW), kaempferol (14.3 mg/kg BW and 28.6 mg/kg BW). After the completion of the treatment mice pre-treated with curcumin, taurine, apigenin and kaempferol were exposed to 2 or 3 Gy of gamma rays. Immediately after irradiation, alkaline comet assay was performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus test

Accidental poisoning with Veratrum album mistaken for wild garlic (Allium ursinum).

Science.gov (United States)

Gilotta, Irene; Brvar, Miran

2010-11-01

Veratrum album (white or false hellebore) is a poisonous plant containing steroidal alkaloids that cause nausea, vomiting, headache, visual disturbances, paresthesia, dizziness, bradycardia, atrioventricular block, hypotension, and syncope. It is regularly mistaken for Gentiana lutea (yellow gentian). We report accidental poisoning with V. album mistaken for Allium ursinum (wild garlic), a wild plant used in soups and salads in Central Europe. Four adults (24-45 years) accidentally ingested V. album mistaken for A. ursinum in self-prepared salads and soups. Within 15-30 min of ingestion they developed nausea, vomiting, and abdominal pain. At the same time dizziness, tingling, dimmed and jumping vision, transient blindness, and confusion appeared. On arrival at the ED, all patients had sinus bradycardia and hypotension. Following treatment the patients were discharged well 24-48 h after ingestion. In patients presenting with gastrointestinal, neurological, and cardiovascular symptoms a history of wild plant ingestion suggests possible poisoning with V. album mistaken for wild garlic.

Control rod ejection analysis during a depressurization accident and the development of a rod-ejection-preventing device

International Nuclear Information System (INIS)

Mitake, S.; Itoh, K.; Fukushima, H.; Inoue, T.

1982-01-01

The control rods used for the experimental VHTR are suspended in the core by means of flexible steel cables and it is conceivable that an accidental rod ejection could occur due to a depressurization accident. The computer code AFLADE was developed in order to analyze the possibility of accidental rod ejection, and several studies were performed. The parametric study results showed that the adopted design condition for the VHTR core will not cause a rod ejection accident. In parallel with these accident analyses, a rod-ejection-preventing device was developed in preparation for a hypothetical accident, and its function was verified by the component tests

Nature of activities and natural, artificial, accidental exposures. Magnitude of these exposures

International Nuclear Information System (INIS)

Aurengo, A.

2009-01-01

The exposure to ionizing radiation (I.R.) is linked to radioelements of organism (9%), earth (12%), cosmic radiation (10%), radon (37%), atmospheric fallout ( nuclear tests 2.5% and industry 0.5%) and to medical procedures (29%). The natural exposure varies in France from 2.5 to 5 mSv by year. In some areas in the world it reaches several tens of mSv by year. The medical exposure is very heterogeneous and concerns particularly old people. For a same examination, the patients exposure varies in an important way ( sometimes from 1 to 10) according to the country, even in France. In France, 250 000 persons are occupationally exposed to ionizing radiation. Among these ones, the most of cases exceeded regulatory limits for exposure to IR concern the health sector. The accidental exposures are in relation with industrial activities (51%) research (20%) civil nuclear (13%) or military (5%) and medical activities (11%). The exposures and then the consequences are very variable, ranging from death to unapparent consequences. in the most of cases a human error is involved and these accidents could have been avoided through measures of prevention and training. (N.C.)

DETECTION OF UNAUTHORIZED CONSTRUCTION EQUIPMENT IN PIPELINE RIGHT-OF-WAYS

International Nuclear Information System (INIS)

James E. Huebler

2002-01-01

Natural gas transmission companies mark the right-of-way areas where pipelines are buried with warning signs to prevent accidental third-party damage. Nevertheless, pipelines are sometimes damaged by third-party construction equipment. A single incident can be devastating, causing death and millions of dollars of property loss. This damage could be prevented if potentially hazardous construction equipment could be detected and identified before the pipeline was damaged. The Gas Technology Institute (GTI) is developing a system to solve this problem by using an optical fiber as a distributed sensor and interrogating the fiber with an optical time domain reflectometer. Key issues are the ability to detect encroachment and the ability to discriminate among potentially hazardous and benign encroachment. The work performed in the first quarter of the project includes development of the Research Management Plan, writing a paper assessing of the state-of-the-art in encroachment and third party damage detection, and development of factors for selecting the optical fiber sensors

Assessment of evolutive and prognostic indicators applied to accidental overexposure to ionizing radiation

International Nuclear Information System (INIS)

Morera Carrillo, M. de Lourdes; Cardenas, J.; Dubner, D.; Perez, M. del Rosario; Gisone, P.

2001-01-01

The acute radiation syndrome has been characterized in different ways that involve risk for life and health of the people overexposed to ionizing radiations. This work intends to test a therapeutical total body irradiation (TBI) model as conditioning to bone marrow transplantation. With the purpose of evaluating the applicability of several biological indicators in accidental overexposures, a study was carried out in 46 patients undergoing TBI receiving doses between 10 Gy and 12 Gy. The following parameters were assessed: lipo peroxyde plasmatic levels (TBARS) and total plasma antioxidant activity, reticulocyte maturity index (RMI) and charges in lymphocyte subpopulations. These data suggest that TBARS could provide an useful evolutive indicator in accidental overexposed patients and RMI is an early indicator of bone marrow recovery after radioinduced aplasia

DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

National Research Council Canada - National Science Library

Thompson, Henry

2002-01-01

The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer...

DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

National Research Council Canada - National Science Library

Thompson, Henry

2001-01-01

The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer...

DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

National Research Council Canada - National Science Library

Thompson, Henry

2003-01-01

The purpose of this project was to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer...

DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

National Research Council Canada - National Science Library

Thompson, Henry

2000-01-01

The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer...

[Can falls be prevented?].

Science.gov (United States)

Dubousset, Jean

2014-06-01

Most recommendations and measures intended to prevent falls focus on the elderly (see HAS guideline of April 2009) but, in our opinion, this isfar too late: prevention must begin much earlier, not only by identifying persons at risk, but also by providing personalized lifestyle advice adapted to each individual's biomechanical, somatic, neurological and biological characteristics. The first preventive measure is to identify a possible deterioration of balance, starting with a physical examination at the age of 45 and repeated regularly throughout life. Extrinsic preventive measures focusing on the domestic and external environments are clearly necessary. But what is most important is to detect and, if necessary, correct any degradation of intrinsic (intracorporeal or somatic) factors starting at the age of 45 years; these include vision, vestibular function and balance, proprioception, and psychological and neurological status. Chronic illnesses and their treatments must also be taken into account: treatment must be limited to indispensable drugs; sedative psychotropics must be avoided if possible; and polymedication must be tightly controlled, as it is a major risk factor for falls. Prevention also requires a diet sufficiently rich in protein, calcium and vitamin D3 (to prevent osteoporosis), and regular daily exercise adapted to the individual, if possible associated with a simultaneous cognitive task. The last key point is the absolute need for thorough functional rehabilitation after any accidental or medical trauma, regardless of age, with the aim of restoring functional status to that existing prior to the accident.

Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin

Science.gov (United States)

Yu, Chia-Chia; Nandrot, Emeline F.; Dun, Ying; Finnemann, Silvia C.

2011-01-01

In the aging human eye, oxidative damage and accumulation of pro-oxidant lysosomal lipofuscin cause functional decline of the retinal pigment epithelium (RPE), which contributes to age-related macular degeneration. In mice with an RPE-specific phagocytosis defect due to lack of αvβ5 integrin receptors, RPE accumulation of lipofuscin suggests that the age-related blindness we previously described in this model may also result from oxidative stress. Cellular and molecular targets of oxidative stress in the eye remain poorly understood. Here we identify actin among 4-hydroxynonenal (HNE) adducts formed specifically in β5−/− RPE but not neural retina with age. HNE modification directly correlated with loss of resistance of actin to detergent extraction, suggesting cytoskeletal damage in aging RPE. Dietary enrichment with natural antioxidants grapes or marigold extract containing macular pigments lutein/zeaxanthin was sufficient to prevent HNE-adduct formation, actin solubility, lipofuscin accumulation, and age-related cone and rod photoreceptor dysfunction in β5−/− mice. Acute generation of HNE-adducts directly destabilized actin but not tubulin cytoskeletal elements of RPE cells. These findings identify destabilization of the actin cytoskeleton as a consequence of physiological, sublethal oxidative burden of RPE cells in vivo that is associated with age-related blindness and that can be prevented by consuming an antioxidant-rich diet. PMID:22178979

Ethical and Unethical Methods of Plagiarism Prevention in Academic Writing

OpenAIRE

Bakhtiyari, Kaveh; Salehi, Hadi; Embi, Mohamed Amin; Shakiba, Masoud; Zavvari, Azam; Shahbazi-Moghadam, Masoomeh; Ale Ebrahim, Nader; Mohammadjafari, Marjan

2014-01-01

This paper discusses plagiarism origins, and the ethical solutions to prevent it. It also reviews some unethical approaches, which may be used to decrease the plagiarism rate in academic writings. We propose eight ethical techniques to avoid unconscious and accidental plagiarism in manuscripts without using online systems such as Turnitin and/or iThenticate for cross checking and plagiarism detection. The efficiency of the proposed techniques is evaluated on five different texts using student...

Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways

Directory of Open Access Journals (Sweden)

Shu-Hua Yang

2016-10-01

Full Text Available Sulforaphane (SFN is a natural and highly effective antioxidant. Studies suggest that SFN protects cells and tissues against cadmium (Cd toxicity. This study investigated the protective effect of SFN against oxidative damage in the testes of Kunming mice exposed to cadmium, and explored the possible molecular mechanisms involved. Cadmium greatly reduced the serum testosterone levels in mice, reduced sperm motility, total sperm count, and increased the sperm deformity rate. Cadmium also reduces superoxide dismutase (T-SOD and glutathione (GSH levels and increases malondialdehyde (MDA concentrations. SFN intervention improved sperm quality, serum testosterone, and antioxidant levels. Both mRNA and protein expression of mouse testicular nuclear factor-erythroid 2-related factor 2 (Nrf2 was reduced in cadmium-treated group. Furthermore, the downstream genes of Nrf2, glutathione peroxidase (GSH-Px, γ-glutamyl cysteine synthetase (γ-GCS, heme oxygenase-1 (HO-1, and NAD(PH:quinone oxidoreductase-1 (NQO1 were also decreased in cadmium-treated group. SFN intervention increases the expression of these genes. Sulforaphane prevents cadmium-induced testicular damage, probably via activation of Nrf2/ARE signaling.

Study of stowage of radioactive materials packagings in accidental conditions

International Nuclear Information System (INIS)

Chevalier, G.; Gilles, P.; Phalippou, C.; Pouard, M.; Draulans, J.; Lafontaine, I.

1987-03-01

The study of transport conditions shows that few data are available on accidental conditions. Two types of accidents are selected and defined by calculations and tests. Sizing of stowage is determined for a frontal shock (35 g deceleration), maintaining the packaging on the vehicle, and side shock rupture of the stowage system for a determined stress. Mathematical formulations are developed [fr

Evaluation of health effects in Sequoyah Fuels Corporation workers from accidental exposure to uranium hexafluoride

International Nuclear Information System (INIS)

Fisher, D.R.; Swint, M.J.; Kathren, R.L.

1990-05-01

Urine bioassay measurements for uranium and medical laboratory results were studied to determine whether there were any health effects from uranium intake among a group of 31 workers exposed to uranium hexafluoride (UF 6 ) and hydrolysis products following the accidental rupture of a 14-ton shipping cylinder in early 1986 at the Sequoyah Fuels Corporation uranium conversion facility in Gore, Oklahoma. Physiological indicators studied to detect kidney tissue damage included tests for urinary protein, casts and cells, blood, specific gravity, and urine pH, blood urea nitrogen, and blood creatinine. We concluded after reviewing two years of follow-up medical data that none of the 31 workers sustained any observable health effects from exposure to uranium. The early excretion of uranium in urine showed more rapid systemic uptake of uranium from the lung than is assumed using the International Commission on Radiological Protection (ICRP) Publication 30 and Publication 54 models. The urinary excretion data from these workers were used to develop an improved systemic recycling model for inhaled soluble uranium. We estimated initial intakes, clearance rates, kidney burdens, and resulting radiation doses to lungs, kidneys, and bone surfaces. 38 refs., 10 figs., 7 tabs

Evaluation of health effects in Sequoyah Fuels Corporation workers from accidental exposure to uranium hexafluoride

Energy Technology Data Exchange (ETDEWEB)

Fisher, D.R. (Pacific Northwest Lab., Richland, WA (USA)); Swint, M.J.; Kathren, R.L. (Hanford Environmental Health Foundation, Richland, WA (USA))

1990-05-01

Urine bioassay measurements for uranium and medical laboratory results were studied to determine whether there were any health effects from uranium intake among a group of 31 workers exposed to uranium hexafluoride (UF{sub 6}) and hydrolysis products following the accidental rupture of a 14-ton shipping cylinder in early 1986 at the Sequoyah Fuels Corporation uranium conversion facility in Gore, Oklahoma. Physiological indicators studied to detect kidney tissue damage included tests for urinary protein, casts and cells, blood, specific gravity, and urine pH, blood urea nitrogen, and blood creatinine. We concluded after reviewing two years of follow-up medical data that none of the 31 workers sustained any observable health effects from exposure to uranium. The early excretion of uranium in urine showed more rapid systemic uptake of uranium from the lung than is assumed using the International Commission on Radiological Protection (ICRP) Publication 30 and Publication 54 models. The urinary excretion data from these workers were used to develop an improved systemic recycling model for inhaled soluble uranium. We estimated initial intakes, clearance rates, kidney burdens, and resulting radiation doses to lungs, kidneys, and bone surfaces. 38 refs., 10 figs., 7 tabs.

Micronuclei: sensitivity for the detection of radiation induced damage

International Nuclear Information System (INIS)

Di Giorgio, M.; Nasazzi, N.B.; Taja, M.R.

1998-01-01

The in vitro cytokinesis-block (CB) micronucleus (MN) assay for human peripheral blood has been used extensively for the assessment of chromosomal damage induced by ionizing radiation and chemicals and considered a suitable biological dosimeter for estimating in vivo whole body exposures, particularly in the case of large scale radiation accidents. One of the major drawbacks of the MN assay is its reduced sensitivity for the detection of damage induced by low doses of low LET radiation, due to the high variability among the spontaneous MN frequencies. It is suggested that age, smoking habit and sex are the main confounding factors that contribute to the observed variability. Previous work in our laboratory, shows a significant positive correlation of the spontaneous and radiation induced MN frequencies with age and smoking habit, the latter being the strongest confounder. These findings led to in vitro studies of the dose-response relationships for smoking and non smoking donors evaluated separately, using 60 Co γ rays. The objectives of the present work are: 1-To increase the amount of data of the dose-response relationships, using γ rays from a 60 Co source, for smoking and non smoking donors, in order to find, if applicable, a correction factor for the calibration curve that takes into account the smoking habit of the individual in the case of accidental overexposure dose assessment, particularly in the low dose range. 2-To establish general conclusions on the current state of the technique. The sample for smoking and non smoking calibration curves was enlarged in the range of 0Gy to 2Gy. The fitting of both curves, performed up to the 2Gy dose, resulted in a linear quadratic model. MN distribution among bi nucleated cells was found to be over dispersed with respect to Poisson distribution, the average ratio of variance to mean being 1.13 for non smokers and 1.17 for smokers. Each fitted calibration curve, for smoking and non smoking donors, fell within the 95

Toxicologia y accidentes de trafico:un estudio a traves de los datos policiales y del samu de la ciudad de valencia

OpenAIRE

Homsi Faraye, Rouaide

2014-01-01

Las lesiones de los accidentes de tráfico y la siniestralidad vial, con sus crecientes cifras y su incidencia diferencial en grupos de edad y género constituyen para la OMS un problema de salud pública de grandes magnitudes en los países industriales, tanto en términos de mortalidad como en términos de secuelas y dependencia. Este crecimiento convertirá los accidentes de tráfico en la quinta causa mundial de muerte. Los politraumatismos secundarios a accidentes de tráfico, laborales o por otr...

Management options in the food chain for accidental radionuclide deposition

International Nuclear Information System (INIS)

Rantavaara, A.

2005-12-01

Finland with four other countries participated in the European Union's network project FARMING in 2000 - 2004. The aim of the project was to invite participants from each country representing the food supply chain in a stakeholder group and advance with the groups the networking in building preparedness for accidental contamination of the food production systems. The task of the groups was to evaluate the practicability of management options suggested for reduction of radiation exposure through foodstuffs, and for disposal of waste generated in implementation of these options. The criteria for practicability were effectiveness in reduction of radiation exposure through foodstuffs, technical feasibility, capacity, costs for implementation, secondary costs for waste disposal, socio-economic impact, and acceptability concerning ecology and protection of environment and landscape. Practicable management options aimed at sustainable restoration of food production systems after accidental contamination. The Finnish stakeholder group represented farm production, processing industry, food marketing, catering, advisor organisations for households and agriculture, consumers, nature conservation, the media, experts on environmental impact and authorities responsible for production, safety and security of foodstuffs, food supply and feedstuffs. The group was expected to examine the effect of the Finnish, and, also more generally, northern production conditions on the practicability of the suggested management options. The stakeholder group members first familiarized themselves with intervention after accidental contamination of a large milk production area and thereafter with practicability of individual management options. The evaluation was based on the group members' complementary expertise that very well covered the chain 'from field to fork' whether the issue was related to legislation, production methods, logistics, environmental impacts, or the issues of consumers and

The Chernobyl – Thirty Years After The Post – Accidental Radiological – Hygienic and Medical Consequences

Directory of Open Access Journals (Sweden)

G. G. Onishchenko

2016-01-01

Full Text Available As the result of the Chernobyl NPP accident more than 200 thousand square kilometers of the European territories were contaminated by Cs-137 in the amount of above 37 kBq/m2 (1 Ci/km2 . Belorussia, Russia and Ukraine amount up to 70% of this entire affected area. More than 600 000 people were engaged in the accidental cleanup operations, 340000 were evacuated or relocated within 1986-1991. The early stage evacuation efficacy is confirmed by the absence of acute radiation syndrome among the population and by the prevented collective dose which amounts to no less than 10 000 man/Sv. The effective measure to reduce the internal radiation dose to the population at the early accidental stage was introduction of maximum tentative permissive levels of radionuclide content in the foodstuffs.Among the identified post -accident medical consequences of the Chernobyl is the radiation syndrome found in 134 emergency cleanup workers within the first 24 hours of the accident’s development. Out of that number, 28 people died within the first four months, 19 people died before 2006. The accident’s liquidators developed radiation -induced leukemia ( the attributive risk value is 45-60% . People exposed to high radiation doses display the statistically significant 18% morbidity increase of all types of solid cancers at the doses above 150 mSv. There is the statistically significant information indicating the increased amount of thyroid cancer morbidity among those who were just children and teenagers at the time of the accident. The adverse psychological consequences are accounted for not just the fear of overexposure but also for the disturbance of the habitual lifestyle especially mindful of the forced relocation.The longterm protection measures, radionuclide decay and selfcleaning of the contaminated areas resulted in the drastic reduction of the population dose in the radioactively contaminated territories. In 2015, only in some settlements of the Briansk

Accidental hypothermia in Poland – estimation of prevalence, diagnostic methods and treatment.

Science.gov (United States)

Kosiński, Sylweriusz; Darocha, Tomasz; Gałązkowski, Robert; Drwiła, Rafał

2015-02-06

The incidence of hypothermia is difficult to evaluate, and the data concerning the morbidity and mortality rates do not seem to fully represent the problem. The aim of the study was to estimate the actual prevalence of accidental hypothermia in Poland, as well as the methods of diagnosis and management procedures used in emergency rooms (ERs). A specially designed questionnaire, consisting of 14 questions, was mailed to all the 223 emergency rooms (ER) in Poland. The questions concerned the incidence, methods of diagnosis and risk factors, as well as the rewarming methods used and available measurement instruments. The analysis involved data from 42 ERs providing emergency healthcare for the population of 5,305,000. The prevalence of accidental hypothermia may have been 5.05 cases per 100.000 residents per year. Among the 268 cases listed 25% were diagnosed with codes T68, T69 or X31, and in 75% hypothermia was neither included nor assigned a code in the final diagnosis. The most frequent cause of hypothermia was exposure to cold air alongside ethanol abuse (68%). Peripheral temperature was measured in 57%, core temperature measurement was taken in 29% of the patients. Peripheral temperature was measured most often at the axilla, while core temperature measurement was predominantly taken rectally. Mild hypothermia was diagnosed in 75.5% of the patients, moderate (32-28°C) in 16.5%, while severe hypothermia (less than 28°C) in 8% of the cases. Cardiopulmonary resuscitation was carried out in 7.5% of the patients. The treatment involved mainly warmed intravenous fluids (83.5%) and active external rewarming measures (70%). In no case was extracorporeal rewarming put to use. The actual incidence of accidental hypothermia in Polish emergency departments may exceed up to four times the official data. Core temperature is taken only in one third of the patients, the treatment of hypothermic patients is rarely conducted in intensive care wards and extracorporeal rewarming

Biokinetics of radionuclides and treatment of accidental intakes

International Nuclear Information System (INIS)

Taylor, D.M.; Stradling, G.N.; Menetrier, F.

2003-01-01

This paper describes the objectives and reviews the progress of EULEP Working Party 5, convened under the auspices of the European Union's Fifth Framework Programme, to 'cluster' two EU-supported contracts, Biokinetics and Dosimetry of Internal Contamination (BIODOS (EU Contract FIS5-1999-00214)) and Radionuclide Biokinetics Database (EULEP) ( RBDATA-EULEP (Concerted Action Contract FIS5-1999-00218), and two non-EU funded projects, Biokinetics of Radionuclides in Human Volunteers (RNHV (non-EU Funded Project) and Treatment of Accidental Intakes of Radionuclides (TAIR (part-funded by EULEP)). (author)

Accidentes de tránsito en carreteras e hipersomnia durante la conducción. ¿es frecuente en nuestro medio? la evidencia periodística

Directory of Open Access Journals (Sweden)

Jorge Rey De Castro Mujica

2003-04-01

Full Text Available Objetivo: Determinar la relación de hipersomnia y los accidentes de transito, según la información periodistica. Material y metodos: Se revisó sistemáticamente la información periodística relacionada a los accidentes de tránsito de las carreteras publicados en el diario "El Comercio" entre los años 1999-2000. Resultados: En ese periodo se escribieron 73 artículos que dieron cuenta de 112 accidentes. Cincuenta y tres 53 (48 % podrían haber estado relacionados a hipersomnia durante el manejo. De acuerdo a esta fuente todos los accidentes causaron un total de 385 muertos y 839 heridos y "la tasa de mortalidad y morbilidad" en los accidentes de ómnibus, probablemente relacionados a hipersomnia, fue 9.7 y 20.6 respectivamente. Conclusión: Con las limitaciones relacionadas a la fuente de información, estos datos sugieren que la hipersomnia durante el manejo causa accidentes de tránsito en nuestro medio cuya prevalencia desconocemos. Asimismo esta información sugiere que los accidentes estarían relacionados a una alta tasa de morbi-mortalidad. Es necesario ampliar la investigación en esta área. ( Rev Med Hered 2003; 14:69-73 .

Guidelines on the medical therapy of persons accidentally overexposed to ionizing radiations. External contamination

International Nuclear Information System (INIS)

Perez, M.R.; Di Trano, J.L.; Gisone, P.

1998-01-01

The document represents a guide for the external decontamination of persons accidentally radio contaminated due to the use, production or transport of radioactive materials. The general conditions, from the medical point of view, to be kept in mind, in the event of accidental overexposures as decontamination treatment and the handling of samples are detailed throughout report. The external contamination without injury in skin or with wound its considered. The distribution of measures and responsibilities for the therapy of the irradiated patients with radioactive materials are enumerated. The preparations of decontaminate solutions are detailed in this work. Moreover, forms for the reception, physical evaluation of the patient and external contamination are presented. (author)

Estimation of the environmental or radiological impact in the event of accidental release of radionuclides in a DCLL fusion reactor; Estimacion del impacto radiologico ambiental en caso de liberacion accidental de radionucleidos en un reactor de fusion DCLL

Energy Technology Data Exchange (ETDEWEB)

Palermo, I.; Gomez Ros, J. M.; Sanz, J.; Mota, F.

2013-07-01

Tritium production and activation in the LiPb products can pose a radiological risk in the event of accidental release in a fusion reactor. Within the research programme Consolider TECNO{sub F}US (CSD2008-079) fusion technology has developed a design for a reactor with regenerative wrap with dual refrigeration (DCLL). The purpose of this communication is to present estimates of the radiological impact derived from an accidental release of radionuclides from the circuit of LiPb provinients. (Author)

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.

Science.gov (United States)

Philpott, Holly T; OʼBrien, Melissa; McDougall, Jason J

2017-12-01

Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine whether CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. Osteoarthritis was induced in male Wistar rats (150-175 g) by intra-articular injection of sodium monoiodoacetate (MIA; 3 mg). On day 14 (end-stage OA), joint afferent mechanosensitivity was assessed using in vivo electrophysiology, whereas pain behaviour was measured by von Frey hair algesiometry and dynamic incapacitance. To investigate acute joint inflammation, blood flow and leukocyte trafficking were measured on day 1 after MIA. Joint nerve myelination was calculated by G-ratio analysis. The therapeutic and prophylactic effects of peripheral CBD (100-300 μg) were assessed. In end-stage OA, CBD dose-dependently decreased joint afferent firing rate, and increased withdrawal threshold and weight bearing (P < 0.0001; n = 8). Acute, transient joint inflammation was reduced by local CBD treatment (P < 0.0001; n = 6). Prophylactic administration of CBD prevented the development of MIA-induced joint pain at later time points (P < 0.0001; n = 8), and was also found to be neuroprotective (P < 0.05; n = 6-8). The data presented here indicate that local administration of CBD blocked OA pain. Prophylactic CBD treatment prevented the later development of pain and nerve damage in these OA joints. These findings suggest that CBD may be a safe, useful therapeutic for treating OA joint neuropathic pain.

Menace of childhood non-accidental traumatic brain injuries: A single unit report

Directory of Open Access Journals (Sweden)

Musa Ibrahim

2015-01-01

Full Text Available Background: Childhood traumatic brain injury (TBI has high rate of mortality and morbidity worldwide. There are dearths of reports from developing countries with large paediatric population on trauma; neurosurgery trauma of nonaccidental origin is not an exemption. This study analysed menace of non-accidental TBI in the paediatric population from our center. Materials and Methods: This is a single unit, retrospective study of the epidemiology of non-accidental TBI in children starting from September, 2008 to March, 2014. The management outcomes of the epidemiology of the non-accidental TBI were analysed. Results: Total of 109 children age range from 0 (intra-natal to 16 years with a mean of 5.8 ± 4.6 years (median, 5 years were enrolled into the study. 34 (31.2% were domestic violence, 26 (23.9% street assaults, 16 (14.7% were due to animal assaults and mishaps, 17 (15.6% fall from heights. Seven (6.4% cases of collapsed buildings were also seen during the period. Four (3.7% industrial accidents and two (1.8% were self-inflicted injuries. There were also three (2.8% cases of iatrogenic TBI out of which two infants (1.8% sustained TBI from cesarean section procedure while one patient (0.9% under general anaesthesia felt from the operation bed resulting to severe TBI. Conclusion: Child abuse, unprotected child labour, parental/care-givers negligence are the main cause of nonaccidental TBI. Human right activists and government agents should be incorporated in curtailing the menace.

A 'Puff' dispersion model for routine and accidental releases

International Nuclear Information System (INIS)

Grsic, Z.; Rajkovic, B.; Milutinovic, P.

1999-01-01

A Puff dispersion model for accidental or routine releases is presented. This model was used as a constitutive part of an automatic meteorological station.All measured quantities are continuously displayed on PC monitor in a digital and graphical form, they are averaging every 10 minutes and sending to the civil information center of Belgrade. In the paper simulation of a pollutant plume dispersion from The oil refinery 'Pancevo', on April 18 th 1999 is presented. (author)

Wooden beverage cases cause little damage to bottle caps

Science.gov (United States)

R. Bruce Anderson; William C. Miller

1973-01-01

Wooden beverage cases cause little damage to aluminum resealable caps during distribution. A study at bottling plants and distribution warehouses showed that an average of 1 bottle out of 4,000 has cap damage. Most of the damage was attributed to handling at the warehouse and in transit. Some recommendations are given for improvement of wooden beverage cases to prevent...

Current controversies in the interpretation of non-accidental head injury

International Nuclear Information System (INIS)

Jaspan, Tim

The field of non-accidental injury (NAI) has been the subject of a number of theories and hypotheses of variable merit. Concerning injuries that occur within the intracranial compartment, much research has been undertaken to investigate the cause of SDH and parenchymal brain injury. Much, however, remains contentious, particularly regarding the medicolegal aspects of suspected child abuse. Issues that present the greatest challenges will be addressed. (orig.)

Current controversies in the interpretation of non-accidental head injury

Energy Technology Data Exchange (ETDEWEB)

Jaspan, Tim [Imaging Centre, University Hospital, Nottingham (United Kingdom)

2008-06-15

The field of non-accidental injury (NAI) has been the subject of a number of theories and hypotheses of variable merit. Concerning injuries that occur within the intracranial compartment, much research has been undertaken to investigate the cause of SDH and parenchymal brain injury. Much, however, remains contentious, particularly regarding the medicolegal aspects of suspected child abuse. Issues that present the greatest challenges will be addressed. (orig.)

Analizan partículas calientes del accidente nuclear de Palomares

OpenAIRE

León Dueñas, Sergio David

2012-01-01

Investigadores pertenecientes al Centro Nacional de Aceleradores, CNA, (Universidad de Sevilla-Junta de Andalucía-CSIC) en colaboración con la Organización Internacional de la Energía Atómica (IAEA), han llevado a cabo me didas de elementos transuránicos en partículas calientes procedentes de accidentes nucleares tales como el de Thule (Groenlandia) o Palomares (España).

Is the tribimaximal mixing accidental?

International Nuclear Information System (INIS)

Abbas, Mohammed; Smirnov, A. Yu.

2010-01-01

The tribimaximal (TBM) mixing is not accidental if structures of the corresponding leptonic mass matrices follow immediately from certain (residual or broken) flavor symmetry. We develop a simple formalism which allows one to analyze effects of deviations of the lepton mixing from TBM on the structure of the neutrino mass matrix and on the underlying flavor symmetry. We show that possible deviations from the TBM mixing can lead to strong modifications of the mass matrix and strong violation of the TBM-mass relations. As a result, the mass matrix may have an 'anarchical' structure with random values of elements or it may have some symmetry that differs from the TBM symmetry. Interesting examples include matrices with texture zeros, matrices with certain 'flavor alignment' as well as hierarchical matrices with a two-component structure, where the dominant and subdominant contributions have different symmetries. This opens up new approaches to understanding the lepton mixing.

Physical exercise prevents short and long-term deficits on aversive and recognition memory and attenuates brain oxidative damage induced by maternal deprivation.

Science.gov (United States)

Neves, Ben-Hur; Menezes, Jefferson; Souza, Mauren Assis; Mello-Carpes, Pâmela B

2015-12-01

It is known from previous research that physical exercise prevents long-term memory deficits induced by maternal deprivation in rats. But we could not assume similar effects of physical exercise on short-term memory, as short- and long-term memories are known to result from some different memory consolidation processes. Here we demonstrated that, in addition to long-term memory deficit, the short-term memory deficit resultant from maternal deprivation in object recognition and aversive memory tasks is also prevented by physical exercise. Additionally, one of the mechanisms by which the physical exercise influences the memory processes involves its effects attenuating the oxidative damage in the maternal deprived rats' hippocampus and prefrontal cortex.

Evaluation of γ-radiation-induced DNA damage in two species of bivalves and their relative sensitivity using comet assay

International Nuclear Information System (INIS)

Praveen Kumar, M.K.; Shyama, S.K.; Sonaye, B.S.; Naik, U Roshini; Kadam, S.B.; Bipin, P.D.; D’costa, A.; Chaubey, R.C.

2014-01-01

Highlights: • Possible genotoxic effect of accidental exposure of aquatic fauna to γ radiation. • Relative sensitivity of bivalves to γ radiation is also analyzed using comet assay. • γ radiation induced significant genetic damage in both the species of bivalves. • P. malabarica and M. casta exhibited a similar level of sensitivity to γ radiation. • Comet assay may be used as a biomarker for the environmental biomonitoring. - Abstract: Ionizing radiation is known to induce genetic damage in diverse groups of organisms. Under accidental situations, large quantities of radioactive elements get released into the environment and radiation emitted from these radionuclides may adversely affect both the man and the non-human biota. The present study is aimed (a) to know the genotoxic effect of gamma radiation on aquatic fauna employing two species of selected bivalves, (b) to evaluate the possible use of ‘Comet assay’ for detecting genetic damage in haemocytes of bivalves as a biomarker for environmental biomonitoring and also (c) to compare the relative sensitivity of two species of bivalves viz. Paphia malabarica and Meretrix casta to gamma radiation. The comet assays was optimized and validated using different concentrations (18, 32 and 56 mg/L) of ethyl methanesulfonate (EMS), a direct-acting reference genotoxic agent, to which the bivalves were exposed for various times (24, 48 and 72 h). Bivalves were irradiated (single acute exposure) with 5 different doses (viz. 2, 4, 6, 8 and 10 Gy) of gamma radiation and their genotoxic effects on the haemocytes were studied using the comet assay. Haemolymph was collected from the adductor muscle at 24, 48 and 72 h of both EMS-exposed and irradiated bivalves and comet assay was carried out using standard protocol. A significant increase in DNA damage was observed as indicated by an increase in % tail DNA damage at different concentrations of EMS and all the doses of gamma radiation as compared to controls in

Evaluation of γ-radiation-induced DNA damage in two species of bivalves and their relative sensitivity using comet assay

Energy Technology Data Exchange (ETDEWEB)

Praveen Kumar, M.K., E-mail: here.praveen@gmail.com [Department of Zoology, Goa University, Goa 403206 (India); Shyama, S.K., E-mail: skshyama@gmail.com [Department of Zoology, Goa University, Goa 403206 (India); Sonaye, B.S. [Department of Radiation Oncology, Goa Medical College, Goa (India); Naik, U Roshini; Kadam, S.B.; Bipin, P.D.; D’costa, A. [Department of Zoology, Goa University, Goa 403206 (India); Chaubey, R.C. [Radiation Biology and Health Science Division, Bhabha Atomic Research Centre, Mumbai (India)

2014-05-01

Highlights: • Possible genotoxic effect of accidental exposure of aquatic fauna to γ radiation. • Relative sensitivity of bivalves to γ radiation is also analyzed using comet assay. • γ radiation induced significant genetic damage in both the species of bivalves. • P. malabarica and M. casta exhibited a similar level of sensitivity to γ radiation. • Comet assay may be used as a biomarker for the environmental biomonitoring. - Abstract: Ionizing radiation is known to induce genetic damage in diverse groups of organisms. Under accidental situations, large quantities of radioactive elements get released into the environment and radiation emitted from these radionuclides may adversely affect both the man and the non-human biota. The present study is aimed (a) to know the genotoxic effect of gamma radiation on aquatic fauna employing two species of selected bivalves, (b) to evaluate the possible use of ‘Comet assay’ for detecting genetic damage in haemocytes of bivalves as a biomarker for environmental biomonitoring and also (c) to compare the relative sensitivity of two species of bivalves viz. Paphia malabarica and Meretrix casta to gamma radiation. The comet assays was optimized and validated using different concentrations (18, 32 and 56 mg/L) of ethyl methanesulfonate (EMS), a direct-acting reference genotoxic agent, to which the bivalves were exposed for various times (24, 48 and 72 h). Bivalves were irradiated (single acute exposure) with 5 different doses (viz. 2, 4, 6, 8 and 10 Gy) of gamma radiation and their genotoxic effects on the haemocytes were studied using the comet assay. Haemolymph was collected from the adductor muscle at 24, 48 and 72 h of both EMS-exposed and irradiated bivalves and comet assay was carried out using standard protocol. A significant increase in DNA damage was observed as indicated by an increase in % tail DNA damage at different concentrations of EMS and all the doses of gamma radiation as compared to controls in

Protocolo de actuación preventiva para riesgo debido a alteraciones del ritmo circadiano en médicos de urgencias que trabajan en turnos de 24 horas Preventive action protocol for risk due to circadian rhythm disturbances in emergency physicians working in 24 hours shifts

Directory of Open Access Journals (Sweden)

Loreto Fillat de Acosta

2009-12-01

Full Text Available La autora analiza la situación patológica de los médicos de urgencias con turnos de 24 horas que alteran el ritmo circadiano, el estudio describe las condiciones de trabajo que afectan el ritmo biológico sueño-vigilia y las tareas intelectuales y de habilidades mecánicas desempeñadas por este personal, los daños a prevenir (accidentes in itinere, accidentes por manipulación de material biológico, enfermedades somáticas y psíquicas y el riesgo para los pacientes. Se propone un protocolo de actuación preventiva que abarca la mayor parte del trabajo, cuándo actuar, revisión de recursos, actuaciones a realizar en una unidad de salud laboral y sistema de comunicación al resto del hospital, Servicio de Prevención de Riesgos Laborales y Sistema Nacional de Salud.The author analyzes the pathological situation concerning to emergency physicians with 24-hour shifts which disturb their circadian rhythms, the study describes the working conditions that affect the biological sleep-wake rhythm and intellectual tasks and mechanical skills performed by these staff, damage to be prevented (commuting accidents, accidents caused by handling of biological material, somatic and psychic diseases and the risk to patients. After that, it's developed a proposal of preventive action protocol covering most of the work and finally when to act, available resources and actions to be taken in an occupational health unit, in addition to the communication system to the rest of the hospital, Occupational and Hazard Preventive Service and the National Health System.

Plasma membrane disruption: repair, prevention, adaptation

Science.gov (United States)

McNeil, Paul L.; Steinhardt, Richard A.

2003-01-01

Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response to disruption. Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages. Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms.

Preventive measures against earthquake damage to museum collections: The recuperation of the exhibits at the Lorca archaeological museum; Medidas de prevencion ante seismos para las colecciones de museos: el caso del museo arqueologico de Lorca y la recuperacion de sus colecciones

Energy Technology Data Exchange (ETDEWEB)

Garcia Alonso, E.; Hernandez, J. A.

2012-11-01

As a result of the earthquake on 11 May 2011 the Lorca municipal archaeological museum suffered serious damage to its structure and its exhibits. The lack of preventive measures and the inadequacy of steps taken before the earthquake aggravated the severity of damage. We have assessed the damage to the exhibits and analysed the causes that exacerbated the impact of the seismic movement. We also describe the work carried out by the Institute of Spain's Cultural Heritage (IPCE) to recuperate the collections and detail the measures and general criteria for the prevention and minimization of damage that the museum must implement to reduce the damage to its collections to a minimum during any subsequent earthquakes. (Author) 12 refs.

Clinical research of teeth damage from radiotherapy

International Nuclear Information System (INIS)

Li Erzhou; Yan Maosheng; Chen Wei; Li Qing

2003-01-01

Objective: To analyze various factors inducing teeth damage from radiotherapy and the preventive and treatment methods. Methods: One hundred cases of patients treated by radiotherapy were divided into two groups. In group one there were 60 cases whose teeth were irradiated during treatment; in group two there were 40 cases whose teeth were not irradiated during treatment. Results: The caries incidence was 60% for group one and 15% for group two (P<0.01). By auto-control in 15 patients, the caries incidence on the sick side was obviously higher than that of the healthy side. Hundred percent caries incidence was found in 6 cases who received a dosage of 70 Gy. Conclusion: The authors believe that radiation damage to the teeth is associated with the following factors: 1. The dosage and location of irradiation are closely related to caries incidence; 2. The active dentinoblasts are very sensitive to radiation; 3. Damage to the salivary glands from radiotherapy can result in reduction of salvia and pH value, leading to a high growth rate of Streptococcus mutans. Following preventive measures could be considered in future cases: to apply a caries prevention coating or protective dental crown and TPS, to adjust the dose and time of irradiation, to select conformal radiotherapy technique. The key points for protecting the teeth and salivary gland from caries and damage are protection of the proliferation ability of pulp cells, anti-inflammation, promotion of microcirculation, and strengthening body resistance

Grape juice concentrate prevents oxidative DNA damage in peripheral blood cells of rats subjected to a high-cholesterol diet.

Science.gov (United States)

Aguiar, Odair; Gollücke, Andréa Pittelli Boiago; de Moraes, Bárbara Bueno; Pasquini, Gabriela; Catharino, Rodrigo Ramos; Riccio, Maria Francesca; Ihara, Silvia Saiuli Miki; Ribeiro, Daniel Araki

2011-03-01

The goal of the present study was to investigate whether subchronic treatment with grape juice concentrate is able to protect liver and peripheral blood cells against cholesterol-induced injury in rats. The effects of the grape juice concentrate treatment on histopathological changes, immunohistochemistry for cyclo-oxygenase-2 (COX-2), and basal and oxidative DNA damage induced by H2O2 using a single-cell gel (comet) assay were evaluated. Male Wistar rats (n 18) were divided into three groups: group 1--negative control; group 2--cholesterol at 1 % (w/w) in their diet, treated for 5 weeks; group 3--cholesterol at 1 % in their chow, treated for 5 weeks, and grape juice concentrate at 222 mg/d in their drinking-water in the final week only. The results indicated that the treatment with grape juice concentrate did not show remarkable differences regarding liver tissue in group 3 compared with group 2. However, grape juice concentrate was able to decrease oxidative DNA damage induced by H2O2 in peripheral blood cells, as depicted by the tail moment results. COX-2 expression in the liver did not show statistically significant differences (P>0·05) between groups. Taken together, the present results suggest that the administration of subchronic grape juice concentrate prevents oxidative DNA damage in peripheral blood cells.

Corrections for the effects of accidental coincidences, Compton scatter, and object size in positron emission mammography (PEM) imaging

Energy Technology Data Exchange (ETDEWEB)

Raymond Raylman; Stanislaw Majewski; Randolph Wojcik; Andrew Weisenberger; Brian Kross; Vladimir Popov

2001-06-01

Positron emission mammography (PEM) has begun to show promise as an effective method for the detection of breast lesions. Due to its utilization of tumor-avid radiopharmaceuticals labeled with positron-emitting radionuclides, this technique may be especially useful in imaging of women with radiodense or fibrocystic breasts. While the use of these radiotracers affords PEM unique capabilities, it also introduces some limitations. Specifically, acceptance of accidental and Compton-scattered coincidence events can decrease lesion detectability. The authors studied the effect of accidental coincidence events on PEM images produced by the presence of 18F-Fluorodeoxyglucose in the organs of a subject using an anthropomorphic phantom. A delayed-coincidence technique was tested as a method for correcting PEM images for the occurrence of accidental events. Also, a Compton scatter correction algorithm designed specifically for PEM was developed and tested using a compressed breast phantom.

Corrections for the effects of accidental coincidences, Compton scatter, and object size in positron emission mammography (PEM) imaging

International Nuclear Information System (INIS)

Raymond Raylman; Stanislaw Majewski; Randolph Wojcik; Andrew Weisenberger; Brian Kross; Vladimir Popov

2001-01-01

Positron emission mammography (PEM) has begun to show promise as an effective method for the detection of breast lesions. Due to its utilization of tumor-avid radiopharmaceuticals labeled with positron-emitting radionuclides, this technique may be especially useful in imaging of women with radiodense or fibrocystic breasts. While the use of these radiotracers affords PEM unique capabilities, it also introduces some limitations. Specifically, acceptance of accidental and Compton-scattered coincidence events can decrease lesion detectability. The authors studied the effect of accidental coincidence events on PEM images produced by the presence of 18F-Fluorodeoxyglucose in the organs of a subject using an anthropomorphic phantom. A delayed-coincidence technique was tested as a method for correcting PEM images for the occurrence of accidental events. Also, a Compton scatter correction algorithm designed specifically for PEM was developed and tested using a compressed breast phantom

Can tail damage outbreaks in the pig be predicted by behavioural change?

DEFF Research Database (Denmark)

Larsen, Mona Lilian Vestbjerg; Andersen, Heidi Mai-Lis; Pedersen, Lene Juul

2016-01-01

preventive methods. One strategy is the surveillance of the pigs' behaviour for known preceding indicators of tail damage, which makes it possible to predict a tail damage outbreak and prevent it in proper time. This review discusses the existing literature on behavioural changes observed prior to a tail...... damage outbreak. Behaviours found to change prior to an outbreak include increased activity level, increased performance of enrichment object manipulation, and a changed proportion of tail posture with more tails between the legs. Monitoring these types of behaviours is also discussed for the purpose......, starting with the description of the temporal development of the predictive behaviour in relation to tail damage outbreaks...

Accidental Entry of Fish into Throat While Bathing in a Pond

Directory of Open Access Journals (Sweden)

Pradipta Kumar Parida

2013-01-01

Full Text Available While fish bones are common foreign bodies in the throat, a whole live fish in the pharynx is very rare. We report a case where a whole fish accidentally entered the throat of a 52-year-old male, where it became lodged causing throat pain and dysphagia. The fish was removed as an emergency procedure.

Accidental cloning of a single-photon qubit in two-channel continuous-variable quantum teleportation

International Nuclear Information System (INIS)

Ide, Toshiki; Hofmann, Holger F.

2007-01-01

The information encoded in the polarization of a single photon can be transferred to a remote location by two-channel continuous-variable quantum teleportation. However, the finite entanglement used in the teleportation causes random changes in photon number. If more than one photon appears in the output, the continuous-variable teleportation accidentally produces clones of the original input photon. In this paper, we derive the polarization statistics of the N-photon output components and show that they can be decomposed into an optimal cloning term and completely unpolarized noise. We find that the accidental cloning of the input photon is nearly optimal at experimentally feasible squeezing levels, indicating that the loss of polarization information is partially compensated by the availability of clones

Causas de los accidentes de trabajo en España: análisis longitudinal con datos de panel Causes of occupational injuries in Spain: a longitudinal analysis with panel data

Directory of Open Access Journals (Sweden)

Inmaculada García Mainar

2009-06-01

Full Text Available Objetivos: Se pretende investigar la influencia de algunas características, tanto de los trabajadores como de los puestos de trabajo que ocupan, en la incidencia de accidentes laborales por categorías (leves, graves, mortales y totales, utilizando herramientas propias del análisis económico. Métodos: Se utiliza un panel de datos para estimar los determinantes de los accidentes agregados de dos formas: por comunidades autónomas y ocupación, y por ramas de actividad y ocupación. Los datos de los accidentes provienen del Ministerio de Trabajo y Asuntos Sociales, y el resto de la Encuesta de Población Activa, para todos los trimestres desde 1999 hasta 2002. Resultados: Un mayor porcentaje de trabajadores con contrato indefinido, del sector público, con estudios secundarios o que han recibido cursos de formación, se asocia con una menor incidencia de accidentes, mientras que una mayor proporción de varones o extranjeros se relaciona con una mayor incidencia. Una mayor experiencia laboral reduce el riesgo de accidente grave o mortal, mientras que más horas de trabajo lo aumentan. Conclusiones: Sería recomendable una mayor actuación para reducir el riesgo de accidente en los trabajadores temporales, los que trabajan en el sector privado, los varones y los extranjeros. Para reducir la incidencia de los accidentes mortales, habría que limitar además el número de horas trabajadas, especialmente en los casos en que no se cuente con una amplia experiencia laboral.Objectives: To investigate the influence of several personal and occupational characteristics on the occurrence of occupation injuries, expressed in different categories (minor, serious, fatal and overall by applying tools that are widely used in economic analyses. Methods: Panel data were used to estimate occupational injuries in an aggregate manner: both by regions and occupational categories and by industries and occupational categories. Data on occupational injuries were drawn

EVOLUCIÓN DE LA MORTALIDAD POR ACCIDENTES INFANTILES Y SU DISTRIBUCIÓN GEOGRÁFICA EN ESPAÑA (1975-1994

Directory of Open Access Journals (Sweden)

Miguel Ruiz Ramos

2001-01-01

Full Text Available Fundamentos: En los países desarrollados los accidentes infantiles ocupan los primeros lugares como causa de mortalidad. El objetivo de este trabajo es describir su evolución en España desde 1975 a 1994, así como su distribución por Comunidades Autónomas. Método: Con las defunciones por accidentes y las poblaciones de España y sus Comunidades Autónomas de 1 a 14 años de las estadísticas oficiales de mortalidad se han calculado los siguientes indicadores: porcentajes sobre el total de defunciones, tasas brutas de mortalidad, tasas ajustadas por edad, tasas específicas por grupos de edad y riesgos relativos. Estos indicadores han sido calculados por género, año de defunción y Comunidad Autónoma. Resultados: Entre 1975 y 1994 se ha reducido la mortalidad por accidentes infantiles en España, en un 3% anual en las niñas y en un 3,5% en los niños. La razón niños/niñas se ha mantenido alrededor de 2. Los accidentes de tráfico han supuesto en torno al 50%. Aragón presentaba el riego relativo más bajo tanto en niñas como en niños, con 0,54 y 0,57 respectivamente, y Galicia el más alto con 1,73 en niñas y 1,91 en niños. El porcentaje sobre el total de defunciones infantiles fue muy variable entre las Comunidades Autónomas, mientras que el porcentaje de accidentes de tráfico estuvo alrededor del 50% en todas las Comunidades Autónomas. Conclusiones: En España la mortalidad por accidentes infantiles ha descendido de una manera notable, en la actualidad se estima que los niños mueren un 50% menos que en 1975. La distribución por Comunidades Autónomas presenta grandes diferencias.

Outcome of accidental hypothermia with or without circulatory arrest. Experience from the Danish Præstø Fjord boating accident

DEFF Research Database (Denmark)

Wanscher, Michael Christopher J; Sørensen, Lisbeth Agersnap; Ravn, Jesper Bohsen

2012-01-01

Resuscitation guidelines for the treatment of accidental hypothermia are based primarily on isolated cases. Mortality rates are high despite aggressive treatment aimed at restoring spontaneous circulation and normothermia.......Resuscitation guidelines for the treatment of accidental hypothermia are based primarily on isolated cases. Mortality rates are high despite aggressive treatment aimed at restoring spontaneous circulation and normothermia....

Accidental Strangulation Due to Entrapment of Saree in Crop Thrasher Machine in an Elderly Women Working at Agricultural Field.

Science.gov (United States)

Parchake, Manoj Bhausaheb; Kumre, Vikas; Kachare, Rajesh V

2016-09-01

Strangulation is generally considered as homicidal death and in accidental strangulation circumstantial evidence alone can point toward the accidental nature of incidence. In present case, a 71-year-old woman, wearing a saree (garment worn by traditional women in India) working in agricultural field, got entangled in the crop thrasher machine and got strangled. Immediately, she was taken to the nearest hospital, where she survived for 6 to 8 hours and then died. The autopsy reveals cross ribbon-shaped ligature mark on neck and anterior chest along with 1 puncture wound at the right lateral aspect of the neck. A lack of proper precaution and safety measures at agricultural field are other contributing factors. Accidental strangulation by saree is extremely rare, hence, this case is presented for its rarity and pattern of injury.

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

Directory of Open Access Journals (Sweden)

Jason Liang

2018-03-01

Full Text Available Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO. Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs selected in the dGCR assay. These dGCRs are formed by non-allelic homologous recombination between divergent DNA sequences mediated by Rad52-, Rrm3- and Pol32-dependent break-induced replication. Combining mms21-CH with sgs1Δ caused a synergistic increase in GCRs rates, indicating the distinct roles of Mms21 and Sgs1 in suppressing GCRs. The mms21-CH mutation also caused increased rates of accumulating uGCRs mediated by breakpoints in unique sequences as revealed by whole genome sequencing. Consistent with the accumulation of endogenous DNA lesions, mms21-CH mutants accumulate increased levels of spontaneous Rad52 and Ddc2 foci and had a hyper-activated DNA damage checkpoint. Together, these findings support that Mms21 prevents the accumulation of spontaneous DNA lesions that cause diverse GCRs.

The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion

Energy Technology Data Exchange (ETDEWEB)

Ganesan, Shanthi, E-mail: shanthig@iastate.edu; Keating, Aileen F., E-mail: akeating@iastate.edu

2016-02-01

Phosphoramide mustard (PM) is an ovotoxic metabolite of cyclophosphamide and destroys primordial and primary follicles potentially by DNA damage induction. The temporal pattern by which PM induces DNA damage and initiation of the ovarian response to DNA damage has not yet been well characterized. This study investigated DNA damage initiation, the DNA repair response, as well as induction of follicular demise using a neonatal rat ovarian culture system. Additionally, to delineate specific mechanisms involved in the ovarian response to PM exposure, utility was made of PKC delta (PKCδ) deficient mice as well as an ATM inhibitor (KU 55933; AI). Fisher 344 PND4 rat ovaries were cultured for 12, 24, 48 or 96 h in medium containing DMSO ± 60 μM PM or KU 55933 (48 h; 10 nM). PM-induced activation of DNA damage repair genes was observed as early as 12 h post-exposure. ATM, PARP1, E2F7, P73 and CASP3 abundance were increased but RAD51 and BCL2 protein decreased after 96 h of PM exposure. PKCδ deficiency reduced numbers of all follicular stages, but did not have an additive impact on PM-induced ovotoxicity. ATM inhibition protected all follicle stages from PM-induced depletion. In conclusion, the ovarian DNA damage repair response is active post-PM exposure, supporting that DNA damage contributes to PM-induced ovotoxicity. - Highlights: • PM exposure induces DNA damage repair gene expression. • Inhibition of ATM prevented PM-induced follicle depletion. • PKCδ deficiency did not impact PM-induced ovotoxicity.

Insect wings as retrospective/accidental/forensic dosimeters: An optically stimulated luminescence investigation

International Nuclear Information System (INIS)

Kazakis, Nikolaos A.; Tsetine, Anastasia Th.; Kitis, George; Tsirliganis, Nestor C.

2016-01-01

Estimation of the radiation released during nuclear accidents or radiological terrorist events is imperative for the prediction of health effects following such an exposure. In addition, in several cases there is a need to identify the prior presence of radioactive materials at buildings or sites (nuclear forensics). To this direction, several materials have been the research object of numerous studies the last decade in an attempt to identify potentially new retrospective/accidental/forensic dosimeters. However, the studies targeting biological materials are limited and their majority is mainly focused on the luminescence behavior of human biological material. Consequently, the use of such materials in retrospective dosimetry presumes the exposure of humans in the radiation field. The present work constitutes the first attempt to seek non-human biological materials, which can be found in nature in abundance or in/on other living organisms. To this end, the present work investigates the basic optically stimulated luminescence behavior of insect wings, which exhibit several advantages compared to other materials. Insects are ubiquitous, have a short life expectancy and exhibit a low decomposition rate after their death. Findings of the present study are encouraging towards the potential use of insects' wings at retrospective/accidental/forensic dosimetry, since they exhibit linear OSL response over a wide dose range and imperceptible loss of signal several days after their irradiation when they are kept in dark. On the other hand, the calculated lower detection limit is not low enough to allow their use as emergency dosimeters when individuals are exposed to non-lethal doses. In addition, wings exhibit strong optical fading when they are exposed to daylight and thus special care should be taken during the sampling procedure in order to use the wings as accidental/forensic dosimeters, by seeking (dead) insects in dark places, such as behind furniture, equipment or in

Evaluación de factores de riesgo en accidentes oculares graves infantiles Assessment of the risk factors for severe ocular accidents in children

Directory of Open Access Journals (Sweden)

Sahely Sixto Fuentes

2010-09-01

Full Text Available Objetivo: Evaluar factores de riesgo en accidentes oculares graves infantiles. Métodos: Se realizó una investigación aplicada, epidemiológica, descriptiva, longitudinal y prospectiva sobre accidentes oculares graves en el Servicio de Oftalmología del Hospital Pediátrico Provincial de Pinar del Río (2006-2007. El universo y muestra estuvo constituido por dos grupos de niños de 1- 20 años, ambos sexos y todas las etnias. Primer Grupo: Niños con accidente ocular grave, Segundo Grupo: Niños sin accidente ocular; determinándose una muestra total de 130 seleccionados mediante muestreo aleatorio simple. Fueron utilizados métodos empíricos y teóricos de investigación científica. Resultados: El trauma ocular representó el 87,8% de los ingresos de urgencia durante el período. Se encontró que el grupo etáreo de 9-12 años (40%, y sexo masculino (89,2% fueron los más afectados. Un 76,9% de los accidentados residía en zona rural. El 96,9% se encontraba fuera de la casa y sin compañía de adultos en el momento del trauma. Predominaron las familias con conocimientos y actitudes evaluados de regulares en relación a los accidentes oculares con un 57,7 % y 60,8% respectivamente. Conclusiones: Se constató elevada frecuencia de traumas oculares infantiles graves en Pinar del Río, precisando sus factores causales de riesgo y dificultades en la prevención de los mismos.Objective: To assess the risk factors for severe ocular accidents in children. Methods: An applied, epidemiological, descriptive, longitudinal and prospective research of the severe ocular accidents was conducted in the Ophthalmologic Service at "Pepe Portilla" Provincial Children Hospital, Pinar del Rio. The target group and the sample were comprised of two groups of children from 1 to 16 years old of both sexes and all ethnics. First group: children and adolescents suffering from severe ocular accidents. Second group: children and adolescents without ocular accidents; a

Fuel Conservation by the Application of Spill Prevention and Failsafe Engineering (A Guideline Manual)

Energy Technology Data Exchange (ETDEWEB)

Goodier, J. Leslie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Water and Land Resources Department, Office of Marine and Environmental Engineering; Siclari, Robert J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Water and Land Resources Department, Office of Marine and Environmental Engineering; Garrity, Phyllis A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Water and Land Resources Department, Office of Marine and Environmental Engineering

1980-10-30

From a series of nationwide plant surveys dedicated to spill prevention, containment and countermeasure evaluation, coupled with spill response action activities, a need was determined for a spill prevention guideline manual. From Federally accumulated statistics for oil and hazardous substance spills, the authors culled information on spills of hydrocarbon products. In 1978, a total of 1456 oil spills were reported compared to 1451 in 1979. The 1978 spills were more severe, however, since 7,289,163 gallons of oil were accidentally discharged. In 1979, the gallons spilled was reduced to 3,663,473. These figures are derived from reported spills; it is highly possible that an equal amount was spilled and not reported. Spills effectively contained within a plant property that do not enter a navigational waterway need not be reported. Needless to say, there is a tremendous annual loss of oil products due to accidental spillage during transportation, cargo transfer, bulk storage and processing. As an aid to plant engineers and managers, Federal workers, fire marshalls and fire and casualty insurance inspectors, the document is offered as a spill prevention guide. The manual defines state-of-the-art spill prevention practices and automation techniques that can reduce spills caused by human error. Whenever practical, the cost of implementation is provided to aid equipment acquisition and installation budgeting. To emphasize the need for spill prevention activities, historic spills are briefly described after which remedial action is defined in an appropriate section of the manual. The section on plant security goes into considerable depth since to date no Federal agency or trade association has provided industry with guidelines on this important phase of plant operation. The intent of the document is to provide finger-tip reference material that can be used by interested parties in a nationwide effort to reduce loss of oil from preventable spills.

Disaster: Prevention, Preparedness and Action.

Science.gov (United States)

Buchanan, Sally

1981-01-01

Discission of threat of disaster to library archival materials focuses on prevention (building maintenance, materials storage, fire prevention), preparedness (preplanning, procedures for handling emergencies, finances of recovery operation), and action (instructions for handling damaged materials). Current library activities in disaster planning…

Guanosine prevents behavioral alterations in the forced swimming test and hippocampal oxidative damage induced by acute restraint stress.

Science.gov (United States)

Bettio, Luis E B; Freitas, Andiara E; Neis, Vivian B; Santos, Danúbia B; Ribeiro, Camille M; Rosa, Priscila B; Farina, Marcelo; Rodrigues, Ana Lúcia S

2014-12-01

Guanosine is a guanine-based purine that modulates glutamate uptake and exerts neurotrophic and neuroprotective effects. In a previous study, our group demonstrated that this endogenous nucleoside displays antidepressant-like properties in a predictive animal model. Based on the role of oxidative stress in modulating depressive disorders as well as on the association between the neuroprotective and antioxidant properties of guanosine, here we investigated if its antidepressant-like effect is accompanied by a modulation of hippocampal oxidant/antioxidant parameters. Adult Swiss mice were submitted to an acute restraint stress protocol, which is known to cause behavioral changes that are associated with neuronal oxidative damage. Animals submitted to ARS exhibited an increased immobility time in the forced swimming test (FST) and the administration of guanosine (5mg/kg, p.o.) or fluoxetine (10mg/kg, p.o., positive control) before the exposure to stressor prevented this alteration. Moreover, the significantly increased levels of hippocampal malondialdehyde (MDA; an indicator of lipid peroxidation), induced by ARS were not observed in stressed mice treated with guanosine. Although no changes were found in the hippocampal levels of reduced glutathione (GSH), the group submitted to ARS procedure presented enhanced glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) activities and reduced catalase (CAT) activity in the hippocampus. Guanosine was able to prevent the alterations in GPx, GR, CAT activities, and in SOD/CAT activity ratio, but potentiated the increase in SOD activity elicited by ARS. Altogether, the present findings indicate that the observed antidepressant-like effects of guanosine might be related, at least in part, to its capability of modulating antioxidant defenses and mitigating hippocampal oxidative damage induced by ARS. Copyright © 2014 Elsevier Inc. All rights reserved.

10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts.

Science.gov (United States)

Zheng, Jinfen; Lai, Wei; Zhu, Guoxing; Wan, Miaojian; Chen, Jian; Tai, Yan; Lu, Chun

2013-10-01

10-Hydroxy-2-decenoic acid (10-HDA) is a major fatty acid component of royal jelly, which has been reported to have a variety of beneficial pharmacological characteristics. However, the effects of 10-HDA on skin photoageing and its potential mechanism of action are unclear. We investigated the protective effects of 10-HDA on ultraviolet (UV) A-induced damage in human dermal fibroblasts (HDFs). We then explored the inhibitory effects of 10-HDA on UVA-induced matrix metalloproteinases (MMPs) expression and elucidated the signalling pathways controlling MMPs inhibition. Primary human dermal fibroblasts were exposed to UVA. Cell proliferation, cellular senescent state and collagen content were analysed using CCK-8, senescence-associated β-galactosidase staining and Sircol collagen assay, respectively. Fluorometric assays were performed to detect the formation of reactive oxygen species (ROS) in the cells. The mRNA levels of MMP-1, MMP-3 and type I (α1) collagen were determined by quantitative real-time PCR. Western blot was applied to detect the expression of MMP-1, MMP-3, JNK and p38 MAPK. HDFs treated with 10-HDA were significantly protected from UVA-induced cytotoxicity, ROS, cellular senescence and stimulated collagen production. Moreover, 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels. Treatment with 10-HDA also reduced the UVA-induced activation of the JNK and p38 MAPK pathways. The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions. Therefore, 10-HDA may be a potential agent for the prevention and treatment of skin photoageing. © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

Can tail damage outbreaks in the pig be predicted by behavioural change?

Science.gov (United States)

Larsen, Mona Lilian Vestbjerg; Andersen, Heidi Mai-Lis; Pedersen, Lene Juul

2016-03-01

Tail biting, resulting in outbreaks of tail damage in pigs, is a multifactorial welfare and economic problem which is usually partly prevented through tail docking. According to European Union legislation, tail docking is not allowed on a routine basis; thus there is a need for alternative preventive methods. One strategy is the surveillance of the pigs' behaviour for known preceding indicators of tail damage, which makes it possible to predict a tail damage outbreak and prevent it in proper time. This review discusses the existing literature on behavioural changes observed prior to a tail damage outbreak. Behaviours found to change prior to an outbreak include increased activity level, increased performance of enrichment object manipulation, and a changed proportion of tail posture with more tails between the legs. Monitoring these types of behaviours is also discussed for the purpose of developing an automatic warning system for tail damage outbreaks, with activity level showing promising results for being monitored automatically. Encouraging results have been found so far for the development of an automatic warning system; however, there is a need for further investigation and development, starting with the description of the temporal development of the predictive behaviour in relation to tail damage outbreaks. Copyright © 2016 Elsevier Ltd. All rights reserved.

ESTADO ACTUAL DE LA PREVENCIÓN DE LOS ACCIDENTES DE MONTAÑA EN ARAGÓN

Directory of Open Access Journals (Sweden)

Ma. Antonia Nerín

2005-01-01

- Establecer las necesidades de los colectivos implicados (usuarios, profesionales e nstituciones para reducir la incidencia y severidad de los accidentes de montaña. Para ello, hemos utilizado los resultados de las campañas institucionales Montañas para Vivirlas Seguro de los años 2000, 2001 y 2002, se han analizado las ocupaciones relacionadas con las actividades deportivas en la montaña y hemos consultado directamente con las instituciones implicadas. El nivel de formación e información del usuario de la montaña en Aragón no es el adecuado para el riesgo potencial de las actividades de montaña; mientras que se evidencia la necesidad de reglar algunas profesiones de la montaña. El rescate en montaña es efectivo, eficaz y eficiente; la medicalización es efectiva, eficaz y no eficiente (atendiendo a los criterios de necesidad, oferta y demanda y la prevención -a pesar de los esfuerzos- es no eficaz, no eficiente y no efectiva. Por todo ello, es urgente la creaciÛn de un servicio de vigilancia de los accidentes de montaña, así como un centro que coordine las propuestas y actuaciones orientadas a prevenir los acci-dentes de montaña.

Modelling accidental releases of tritium in the environment: application as an excel spreadsheet

International Nuclear Information System (INIS)

Le Dizes, S.; Tamponnet, C.

2004-01-01

An application as an Excel spreadsheet of the simplified modelling approach of tritium transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the two-pool model (organic tritium and tritiated water) that was developed estimates the concentration of tritium within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of tritium in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of tritium in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)

Preventing thefts and wilful damage

CERN Multimedia

DG Unit

2011-01-01

The best means of preventing crime is to make it difficult to commit. As the summer holidays begin, in everybody’s interest we advise the following precautions: 1. MONEY, VALUABLES & KEYS Never leave money or objects of value unattended in offices or changing rooms, even locked. Keys and spares must always be taken away or kept in a safe place. Supposedly “safe” hiding places such as drawers, even locked, metal boxes and flower pots, are well known to burglars and should be avoided. Change lock codes regularly. 2. DOORS & WINDOWS Offices, workshops and meeting-rooms, etc. should be locked when vacated. Care should also be taken that windows are properly shut, especially if they are easily accessible from the outside. 3. VANDALISM If you witness an act of vandalism of public or private property, please report all the facts and your observations immediately to the CERN Fire Brigade (74444). 4. REPORTING INCIDENTS Every misdemeanour solved increases the chances of others be...

Liability for damage to the global commons

International Nuclear Information System (INIS)

Leigh, K.

1993-01-01

The 'global commons' discussed in this paper are the areas beyond the limits of national jurisdiction. Responsibility to prevent environmental damage to these areas is clearly recognized in customary international law. On the other hand, although liability for such damage undoubtedly has a useful role to play in protecting these areas, the precise nature of liability for such damage is unclear. Some issues, such as whether liability for such damage is strict or tied to breaching a standard of care and the definition of environmental damage, equally arise in relation to damage to the environment of States. Others, such as who could take action to enforce the liability and the nature of the remedy, raise special problems in the case of damage to the global commons. The work under way in the IAEA Standing Committee on Liability for Nuclear Damage provides an opportunity for clarifying these issues in relation to nuclear damage to the global commons. Treaties dealing with particular types of damage which have recently been adopted or are currently being developed in other fields provide a starting point in dealing with this matter. More work, however, needs to be done

The accidental (acoustical) tourist

Science.gov (United States)

Van Kirk, Wayne

2002-11-01

The acoustical phenomenon observed at an ancient temple in the Great Ball Court at Chichen Itza was described as ''little short of amazing--an ancient whispering gallery'' by Silvanus G. Morley, leader of the Carnegie Institute's archaeological team that excavated and restored these structures in the 1920s. Since then, many others have experienced the extraordinary acoustics at Chichen Itza and other Maya sites. Despite these reports, archaeologists and acousticians have until recently shown little interest in understanding these phenomena. After experiencing Chichen Itza's remarkable acoustics as a tourist in 1994, the author commenced collecting and disseminating information about acoustical phenomena there and at other Mayan sites, hoping to stimulate interest among archaeologists and acousticians. Were these designs accidental or intentional? If intentional, how was the knowledge obtained? How were acoustical features used? This paper highlights the author's collection of anecdotal reports of mysterious Mayan acoustics (http://http://www.ianlawton.com/pa1.htm), recommended reading for scientists and engineers who wish to pursue this fascinating study. Also recounted are some of the reactions of archaeologists-ranging from curious, helpful, and insightful to humorous and appalling--to outsiders' efforts to bring serious scientific attention to the new field of acoustical archaeology.

Work-related accidents and diseases take a heavy toll worldwide Los accidentes y enfermedades laborales causan gran mortalidad en todo el mundo

Directory of Open Access Journals (Sweden)

2002-08-01

Full Text Available Cada año mueren en todo el mundo unos dos millones de personas por enfermedades y accidentes laborales, pero la repercusión total es mucho mayor aun. Según el informe de la Organización Internacional del Trabajo (OIT titulado Informe introductorio: trabajo decente, trabajo seguro, de mayo de 2002, dependiendo del tipo de trabajo, por cada accidente mortal se producen 500 a 2 000 lesiones. Según la OIT, la principal causa de muerte relacionada con el trabajo es el cáncer, responsable de 32% de las muertes, seguido de las enfermedades circulatorias (23%, los accidentes (19% y las enfermedades transmisibles (17%. Las lesiones y las enfermedades laborales suponen un considerable costo económico. Cerca de 4% del producto interno bruto (PIB mundial se pierde en gastos de tratamiento e ingresos no percibidos. El informe de la OIT dice que se podría prevenir cerca de 80% de los accidentes y muertes laborales si todos los países que pertenecen a la organización aplicaran los métodos de prevención de accidentes ya existentes. En los países industrializados, las prioridades deben ser los factores psicosociales ligados a las malas relaciones y gestiones en el lugar de trabajo, las consecuencias mentales y físicas de las tareas repetitivas muy técnicas y la información sobre la manipulación de las nuevas tecnologías y sustancias, entre ellas los productos químicos. En los países que todavía están en fase de industrialización se les debería dar prioridad al mejoramiento de las prácticas sanitarias y de seguridad en las actividades primarias, como la agricultura, la pesca y la explotación maderera; la prevención de los accidentes industriales y la prevención de los accidentes y enfermedades en talleres informales e industrias domésticas.

Factores asociados a los accidentes por exposición percutánea en personal de enfermería en un hospital de tercer nivel

Directory of Open Access Journals (Sweden)

Gallardo López Mª Teresa

1997-01-01

Full Text Available FUNDAMENTO: Los accidentes por exposición percutánea suponen aproximadamente un tercio de los accidentes laborales del personal sanitario hospitalario. Su importancia estriba en las enfermedades causadas por patógenos transmisibles por esta vía (hepatitis B, hepatitis C, infección VIH. Objetivos: describir los accidentes de este tipo notificados en un hospital de tercer nivel; identificar factores asociados a estos accidentes en personal de enfermería; construir un modelo predictivo del riesgo individual de accidentarse. MÉTODOS: Estudio descriptivo de una cohorte retrospectiva compuesta por todas las personas que notificaron un accidente entre el 1-1-93 y el 30-6-96. Estudio de casos y controles en el personal de enfermería durante el período 1-1-95 al 30-6-96, analizado mediante regresión logística múltiple. RESULTADOS: La incidencia acumulada de accidentes en un año fue de 0,078 para las/-os enfermeras/-os. En el 57,3% de los casos estuvieron implicadas agujas de jeringas desechables o precargadas. La incidencia acumulada en un año fue mayor para las agujas de cateterismo intravenoso (8,5 por 100.000. El riesgo de accidentabilidad, ajustado por variables confundentes, fue mayor para las/-os enfermeras/-os (OR=3,22; I.C.95%=1,96-5,27, para los trabajadores de la Unidad de Hemodiálisis (OR=35,21; I.C.95%=3,74-331,16 y para aquéllos con contrato eventual (OR=4,50; I.C.95%=2,24-9,04. CONCLUSIONES: Los accidentes por exposición percutánea en este hospital son más frecuentes entre el personal de enfermería y se producen, fundamentalmente, con algún tipo de aguja hueca. Se han identificado factores asociados a estos accidentes, lo que permite dirigir programas preventivos específicos sobre trabajadores con más riesgo. El modelo obtenido es válido para estimar el grado de accidentabilidad individual en los sujetos estudiados.

Early diagnosis and monitoring of whole-body accidental exposure

International Nuclear Information System (INIS)

Flury-Herard, A.; Jullien, D.

1987-01-01

This paper deals with the handling of accidental, acute or protracted, whole-body overexposures. It is complementary to the report DPS 86/07 SEAPS previously published. The criteria for initial classification, as a function of the mean absorbed dose, the clinical and paraclinical evaluation, the monitoring methods and the treatments to undertake are described successively. The basic components of the therapy are the intensive care of the hematological syndrome with blood products transfusions and anti-infection prophylaxy. The indications and conditions for bone-marrow grafts are also discussed [fr

Evaluation and mitigation of accidental releases of radioactivity

International Nuclear Information System (INIS)

Bruessermann, K.

1982-12-01

One result of the workshop was, that even in the case of severe accident sequences in modern nuclear power plants (other facilities were not discussed), there will be enough time to take active measures in order to lower the emissions and to diminish the consequences inside and outside of the plant. On the whole, new evidence from Harrisburg show that previously estimated accidental emissions, especially of radiologically relevant nuclides, have been rather conservative and that much lower emissions are possible, if the above measures are considered. Under accident conditions, models to predict radiation exposure must be applied under the event of a short-term release. (orig./DG) [de

Radioactive releases into the environment under accidental conditions

International Nuclear Information System (INIS)

Beninson, D.

1976-01-01

Although accidents involving the release of radioactive materials and the unplanned exposure of people can occur at any stage of the nuclear fuel cycle, most attention has been focused on reactor accidents. Although no power reactor accidents involving exposure of the public have yet occured, it should be recognized that the probability of such accidental releases cannot be reduced to zero. Since the inventory of radioactive materials in power reactors is very large, it is usual to postulate, for safety assessments, that a release of fission products takes place in spite of all protective measures. This postulated release is of importance for reactor siting and for preparing emergency plans. (HP) [de

radionuclides modelling dispersion of in the atmosphere for continuous discharges and accidental

International Nuclear Information System (INIS)

Teyeb, Malika

2011-01-01

The study of the dispersion of radionuclides in the atmosphere is the subject of a physical and numerical modeling of the phenomenon of dispersion. This work aims to study the atmospheric dispersion of accidental releases and continuous, from the possible establishment of a nuclear pressurized water reactor in the potential in Bizerte and Skhira.

Accidental pollution in the ocean: besides crude oil, chemicals and other spills

International Nuclear Information System (INIS)

Marchand, M.

2003-01-01

Accidental pollution of the seas is usually illustrated by the shipwreck of tankers carrying crude oil. We must look beyond this image since such accidents spill substances other than petrochemicals. We need but mention the Levoli Sun's accident near the Cotentin peninsula, France, one year after the Erika went down. And what about spills of agricultural and food products? An accidental spill as apparently harmless as wheat might have serious effects on not just the environment but also human health. In all cases, two major series of questions crop up: 1) Is it necessary to intervene? If so, are we able to? And if we can, how to fight against spills? 2) What are the short- and long-term effects on the environment and on all human activities related to the sea (fishing, fish-farming, salt production, tourism, salt-water cures, etc.)? These two questions have a common denominator: the need to know how spilled products react. This knowledge conditions both the operational response for fighting against pollution and the assessment of the impact on the maritime environment. (author)

Accidental phosgene gas exposure: A review with background study of 10 cases

Directory of Open Access Journals (Sweden)

Arvind Kumar Vaish

2013-01-01

Full Text Available Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema. Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome.

[Implementation of safety devices: biological accident prevention].

Science.gov (United States)

Catalán Gómez, M Teresa; Sol Vidiella, Josep; Castellà Castellà, Manel; Castells Bo, Carolina; Losada Pla, Nuria; Espuny, Javier Lluís

2010-04-01

Accidental exposures to blood and biological material were the most frequent and potentially serious accidents in healthcare workers, reported in the Prevention of Occupational Risks Unit within 2002. Evaluate the biological percutaneous accidents decrease after a progressive introduction of safety devices. Biological accidents produced between 2.002 and 2.006 were analyzed and reported by the injured healthcare workers to the Level 2b Hospital Prevention of Occupational Risk Unit with 238 beds and 750 employees. The key of the study was the safety devices (peripheral i.v. catheter, needleless i.v. access device and capillary blood collection lancet). Within 2002, 54 percutaneous biological accidents were registered and 19 in 2006, that represents a 64.8% decreased. There has been no safety devices accident reported involving these material. Accidents registered during the implantation period occurred because safety devices were not used at that time. Safety devices have proven to be effective in reducing needle stick percutaneous accidents, so that they are a good choice in the primary prevention of biological accidents contact.

Commitment of involved actors in the preparation of accidental and post-accident situations: European experiments

International Nuclear Information System (INIS)

Schneider, Th.

2010-01-01

The author briefly describes some approaches developed within the EURANOS European research programme between 2004 and 2009 which aims at promoting the building up of a European network (NERIS) for the management of nuclear accidental and post-accident situations. Notably, he comments the experiment which took place in the Montbeliard district where two types of radiological events have been modelled and simulated: an accident in the Fessenheim nuclear power plant with two scenarios of release, and a transportation accident with a release of radioactive caesium 137. He also evokes the Norwegian experience and some other actions in Finland, Great-Britain, Spain and Slovakia where reflections on the management of accidental and post-accident situations or crisis exercises have been organized

Suicide verdicts as opposed to accidental deaths in substance-related fatalities (UK, 2001-2007).

Science.gov (United States)

Vento, Alessandro E; Schifano, Fabrizio; Corkery, John M; Pompili, Maurizio; Innamorati, Marco; Girardi, Paolo; Ghodse, Hamid

2011-07-01

Substance-related deaths account for a great number of suicides. To investigate levels and characteristics of suicide verdicts, as opposed to accidental deaths, in substance misusers. Psychological autopsy study of cases from the UK National Programme on Substance Abuse Deaths (np-SAD) during the period 2001-2007. Between January 2001 and December 2007, 2108 suicides were reported to the np-SAD. Typical suicide victims were White and older than 50 (respectively 95% and 41% of cases). Medications, especially antidepressants (44%), were prescribed to 87% of victims. Significantly fewer suicide victims than controls presented positive blood toxicological results for illicit drugs (namely: cocaine, heroin, amphetamines, ecstasy-type drugs, cannabis, and GHB/GBL) and alcohol. Suicide prevention programmes should devote specific attention to deaths among substance misusers who are at high risk of fatal intentional self-harm. Specific characteristics distinguish those at risk; caregivers should be better educated as to what these factors are. Limitations of the current study included lack of provision of comprehensive information relating to the victims' psychosocial variables. Furthermore, no differentiation between different classes of antidepressants in terms of involvement in suicide was here provided. Copyright © 2011 Elsevier Inc. All rights reserved.

[Recommendations for the prevention of drowning].

Science.gov (United States)

Rubio, B; Yagüe, F; Benítez, M T; Esparza, M J; González, J C; Sánchez, F; Vila, J J; Mintegi, S

2015-01-01

Drowning is the second leading cause of non-intentional death in children under the age of 19 in Europe. Weather conditions in Spain allow an extended period of contact with water, therefore increasing the risk of drowning (due to the increased exposure), and constitutes the second leading cause of accidental death in children less than 14 years of age. In children younger than 5 years, drowning occurs mostly in pools belonging to private homes or communities, while in older children, drowning is often linked to aquatic recreational activities in lakes, sea, rivers and canals, and at times associated with alcohol consumption. In this article, the Committee on Safety and Non-Intentional Injury Prevention in Childhood of the Spanish Association of Pediatrics provides a series of architectonic, educational and legislative recommendations to prevent such incidents. Copyright © 2014 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

Preventive effects of benfotiamine in chronic diabetic complications.

Science.gov (United States)

Chakrabarti, Rana; Chen, Megan; Liu, Weihua; Chen, Shali

2011-04-07

Aims/Introduction:  In diabetes, increased oxidative stress as a result of damage to the electron transport chain can lead to tissue injury through upregulation of multiple vasoactive factors and extracellular matrix proteins. Benfotiamine, a lipid soluble thiamine derivative, through reducing mitochondrial superoxide production, blocks multiple pathways leading to tissue damage in hyperglycemia. We investigated if treatment with benfotiamine can prevent diabetes-induced production of vasoactive factors and extracellular matrix proteins, and whether such effects are tissue-specific. We also examined whether effects of benfotiamine are mediated through a nuclear mechanism.   Retinal, renal and cardiac tissues from the streptozotocin-induced diabetic rats were examined after 4 months of follow up. mRNA levels were quantified using real-time RT-PCR. Protein levels were quantified using western blot and ELISA. Cellular expressions of 8-Hydroxy-2'-deoxyguanosine, a marker of nuclear DNA damage and Phospho-H2AX were also examined.   Diabetic animals showed hyperglycemia, glucosuria, increased urinary albumin/creatine ratio and loss of bodyweight. In the kidneys, heart and retina, diabetes caused increased production of endothelin-1, transforming growth factor-β1, vascular endothelial growth factor and augmented extracellular matrix proteins (collagen, fibronectin [FN] and its splice variant extradomain B containing FN), along with evidence of structural alterations, characteristic of diabetes-induced tissue damage. Such changes were prevented by benfotiamine. Furthermore, benfotiamine prevented diabetes-induced oxidative DNA damage and upregulation of p300, a histone acetylator and a transcription coactivator.   Data from the present study suggest that benfotiamine is effective in preventing tissue damage in diabetes and at the transcriptional level such effects are mediated through prevention of p300 upregulation. (J Diabetes Invest, doi: 10.1111/j.2040

Fibroelastoma valvular aórtico como causa de accidente cerebrovascular embólico: Reporte de un caso

OpenAIRE

BAHAMONDES S,JUAN CARLOS; MERIÑO S,GUSTAVO; SALMAN A,JUAN; SILVA V,ABELARDO; MORA M,JAVIER

2008-01-01

Los tumores cardíacos son una causa rara de accidente cerebrovascular embólico. Comunicamos el caso de una paciente de 65 años quien debuta su historia con un accidente cerebrovascular. El estudio de fuente embólica con ecocardiografía transesofágica demostró un fibroelastoma de la válvula aórtica en el borde libre del velo no coronariano. El tumor fue extraído mediante circulación extracorpórea. El estudio anatomopatológico confirmó el diagnóstico y la paciente se encuentra en capacidad func...

Accidentes en los niños, un problema de salud actual: Revisión bibliográfica

OpenAIRE

Valdés Pacheco, Everardo; Ferrer Liranza, Nancy; Ferrer Liranza, Amed

1996-01-01

Se realiza una revisión bibliográfica sobre el tema Accidente, especialmente en los niños, y se resalta la importancia de la prevención de éstos, pues constituyen la primera causa de muerte en nuestro país en los menores entre 1 y 14 años de edad. Se brinda información sobre los tipos y causas principales de accidentes en estas edades, así como las recomendaciones para la labor preventiva del equipo de salud en la atención primaria.A bibliographic review on the topic of accidents, specially i...

Critical experiments simulating accidental water immersion of highly enriched uranium dioxide fuel elements

International Nuclear Information System (INIS)

Ponomarev-Stepnoi, N.N.; Glushkov, L.S.

2003-01-01

The paper focuses on experimental analysis of nuclear criticality safety at accidental water immersion of fuel elements of the Russian TOPAZ-2 space nuclear power system reactor. The structure of water-moderated heterogeneous critical assemblies at the NARCISS facility is described in detail, including sizes, compositions, densities of materials of the main assembly components for various core configurations. Critical parameters of the assemblies measured for varying number of fuel elements, height of fuel material in fuel elements and their arrangement in the water moderator with a uniform or variable spacing are presented. It has been found from the experiments that at accidental water immersion of fuel elements involved, the minimum critical mass equal to approximately 20 kg of uranium dioxide is achieved at 31-37 fuel elements. The paper gives an example of a physical model of the water-moderated heterogeneous critical assembly with a detailed characterization of its main components that can be used for calculations using different neutronic codes, including Monte Carlo ones. (author)

Damage Curves of a Nuclear Reactor Structure exposed to Air Blast Loading

International Nuclear Information System (INIS)

Brandys, I.; Ornai, D.; Ronen, Y.

2014-01-01

Nuclear Power Plant (NPP) radiological hazards due to accidental failure or deliberated attacks are of most concern due to their destructive and global consequences: large area contaminations, injuries, exposure to ionizing radiation (which can cause death or illness, depends on the levels of exposure), loss of lives of both humans and animals, and severe damage to the environment. Prevention of such consequences is of a global importance and it has led to the definition of safety & design guidelines, and regulations by various authorities such as IAEA, U.S. NRC, etc. The guidelines define general requirements for the integrity of a NPP’s physical barriers (such as protective walls) when challenged by external events, for example human induced explosion. A more specific relation to the design of a NPP is that its structures and equipment (reactor building, fuel building, safeguards building, diesel-generator building, pumping station, nuclear auxiliaries building, and effluent treatment building) must function properly: shutdown the reactor, removal of decayed heat, storage of spent fuel, and treatment and containment of radioactive effluents) under external explosion. It requires that the NPP’s structures and equipment resistance to external explosion should be analyzed and verified. The air blast loading created by external explosion, as well as its effects & consequences on different kinds of structures are described in the literature. Structural elements response to the air blast can be analyzed in general by a Single Degree of Freedom (SDOF) system that converts a distributed mass, loads, and resistance to concentrated mass, force, and stiffness located at a representative point of the structure's element where the displacements are the highest one. Proper shielding should be designed if the explosion blast effects are greater than the resistance capacity.External explosion effects should be considered within the Screening Distance Value (SDV) of the NPP

30 CFR 250.300 - Pollution prevention.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pollution prevention. 250.300 Section 250.300... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a... pollution occurs as a result of operations conducted by or on behalf of the lessee and the pollution damages...

Perfil epidemiológico de la discapacidad por accidentes de tránsito en el Perú, 2012

Directory of Open Access Journals (Sweden)

César Gutiérrez

Full Text Available Objetivos. Describir el perfil epidemiológico de las personas discapacitadas por accidentes de tránsito (AT en Perú. Materiales y métodos. Análisis secundario de la Encuesta Nacional Especializada Sobre Discapacidad (ENEDIS del año 2012. Además, se realizó un análisis ecológico con los registros de AT del Ministerio de Transportes y Comunicaciones. Resultados. 49 036 personas reportaron algún tipo de discapacidad por accidentes de tránsito (DAT; 81,3% de los discapacitados reside en zonas urbanas. La discapacidad reportada más frecuente fue limitación en la locomoción y destreza (77,4%, seguida de la discapacidad visual (22,9%. Se reporta dependencia en 44,7% de las personas con discapacidad. Las regiones con mayor prevalencia de AT presentan mayor prevalencia de discapacidad por accidente de tránsito (Coeficiente de Spearman: 0,426, p=0,034. Conclusiones. La mayor parte de los discapacitados por AT proceden de la zona urbana, son varones y se encuentran en la edad económicamente productiva. La forma más común de limitación es la de locomoción. Gran parte de los afectados no reciben ningún tipo de rehabilitación, lo que acentúa la inequidad en salud relacionada a los accidentes de tránsito

The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

NARCIS (Netherlands)

Jansen, B.J.

2011-01-01

In this research I examine social ordering processes in Kakuma refugee camp in

Kenya. I view the camp as an accidental city, by which I challenge the image of

the camp as a temporary and artificial waiting space or a protracted refugee crisis

per se. The reference to the

Early MEK1/2 Inhibition after Global Cerebral Ischemia in Rats Reduces Brain Damage and Improves Outcome by Preventing Delayed Vasoconstrictor Receptor Upregulation

DEFF Research Database (Denmark)

Johansson, Sara Ellinor; Larsen, Stine Schmidt; Povlsen, Gro Klitgaard

2014-01-01

BACKGROUND: Global cerebral ischemia following cardiac arrest is associated with increased cerebral vasoconstriction and decreased cerebral blood flow, contributing to delayed neuronal cell death and neurological detriments in affected patients. We hypothesize that upregulation of contractile ETB...... and 5-HT1B receptors, previously demonstrated in cerebral arteries after experimental global ischemia, are a key mechanism behind insufficient perfusion of the post-ischemic brain, proposing blockade of this receptor upregulation as a novel target for prevention of cerebral hypoperfusion and delayed...... neuronal cell death after global cerebral ischemia. The aim was to characterize the time-course of receptor upregulation and associated neuronal damage after global ischemia and investigate whether treatment with the MEK1/2 inhibitor U0126 can prevent cerebrovascular receptor upregulation and thereby...

Postprocessing of Accidental Scenarios by Semi-Supervised Self-Organizing Maps

Directory of Open Access Journals (Sweden)

Francesco Di Maio

2017-01-01

Full Text Available Integrated Deterministic and Probabilistic Safety Analysis (IDPSA of dynamic systems calls for the development of efficient methods for accidental scenarios generation. The necessary consideration of failure events timing and sequencing along the scenarios requires the number of scenarios to be generated to increase with respect to conventional PSA. Consequently, their postprocessing for retrieving safety relevant information regarding the system behavior is challenged because of the large amount of generated scenarios that makes the computational cost for scenario postprocessing enormous and the retrieved information difficult to interpret. In the context of IDPSA, the interpretation consists in the classification of the generated scenarios as safe, failed, Near Misses (NMs, and Prime Implicants (PIs. To address this issue, in this paper we propose the use of an ensemble of Semi-Supervised Self-Organizing Maps (SSSOMs whose outcomes are combined by a locally weighted aggregation according to two strategies: a locally weighted aggregation and a decision tree based aggregation. In the former, we resort to the Local Fusion (LF principle for accounting the classification reliability of the different SSSOM classifiers, whereas in the latter we build a classification scheme to select the appropriate classifier (or ensemble of classifiers, for the type of scenario to be classified. The two strategies are applied for the postprocessing of the accidental scenarios of a dynamic U-Tube Steam Generator (UTSG.

Si pudiese volver no cambiaría ese día: el relato de una joven tras sufrir un accidente de tráfico

Directory of Open Access Journals (Sweden)

Celia Martí García

Full Text Available Los accidentes de tráfico son causa de un porcentaje bastante elevado de muertes en los países occidentalizados. Si hablamos de accidentes de moto, los factores de riesgo para que la persona sufra daños mayores se ven multiplicados, sobre todo si tenemos en cuenta lo desprotegida que va la víctima y las velocidades a las que se suelen producir este tipo de accidentes. La informante de este relato nos contará la vivencia que supuso para ella sufrir un accidente en motocicleta cuando tenía 15 años, las intervenciones quirúrgicas a las que tuvo que someterse, y su reincorporación académica. En definitiva, cómo le ha influido en su vida y qué secuelas le ha dejado su exceso de velocidad.

Development of management tools for accidental radiological contamination of the French coastal areas - Development of management tools for accidental radiological contamination in the French marine coastal areas

Energy Technology Data Exchange (ETDEWEB)

Duffa, C.; Charmasson, S. [IRSN/PRP-ENV/SESURE/LERCM - Antenne de Radioecologie Marine, Centre Ifremer, Zone portuaire de Bregaillon, 13507 La Seyne sur Mer (France); Bailly du Bois, P.; Fievet, B. [IRSN/PRP-ENV/SERIS/LRC (France); Couvez, C.; Renaud, P. [IRSN/PRP-ENV/SESURE/DIR (France); Didier, D. [IRSN/PRP-CRI/SESUC/BMTA (France)

2014-07-01

The Fukushima nuclear accident led to the most important accidental release of artificial radionuclides into the sea. This accident has underlined the importance of being able to adequately reproduce the fate of radioactive releases and to estimate their consequences for the marine environment. For its Crisis Centre, the French Institute for Radioprotection and Nuclear Safety (IRSN) has operational tools, in order to help experts and decision makers in case of any atmospheric accidental release and terrestrial environment contamination. The on-going project aims to develop tools to manage any marine contamination of the French coastal areas. We should be able to evaluate and anticipate the marine post-accidental situation: contaminated areas localization and contamination levels, and possible consequences. Many sites has be considered as potential source terms into the sea: the Coastal Nuclear Power Plants, the La Hague reprocessing Plant, the Brest and Toulon Military Harbours as home-ports of nuclear powered vessels, and different river mouths (Rhone River, Gironde, Loire, Seine) that could be contaminated by upstream accidental release. To achieve this goal, two complementary approaches are developed: Marine sheets and a dedicated modelling tool (STERNE). - Marine sheets aim to summarize marine environment characteristics for the different sites, identify potential stakes for human protection such as aquaculture areas, beaches, or industrial water intakes, and ecological stakes. Whenever possible, a local climatology (main currents depending on meteorological or tide conditions) that could be a support to first environmental measurement strategy is proposed. A list of available local contacts for any operational management is also provided. - The modelling tool, STERNE (Simulation du Transport et du transfert d'Elements Radioactifs dans l'environNEment marin), must predict radionuclide dispersion and contamination of water, marine species and sediments

Photoexcited riboflavin induces oxidative damage to human serum albumin

Science.gov (United States)

Hirakawa, Kazutaka; Yoshioka, Takuto

2015-08-01

Photoexcited riboflavin induced damage of human serum albumin (HSA), a water soluble protein, resulting in the diminishment of fluorescence from the tryptophan residue. Because riboflavin hardly photosensitized singlet oxygen generation and sodium azide, a singlet oxygen quencher, did not inhibit protein damage, electron transfer-mediated oxidation of HSA was speculated. Fluorescence lifetime of riboflavin was not affected by HSA, suggesting that the excited triplet state of riboflavin is responsible for protein damage through electron transfer. In addition, the preventive effect of xanthone derivatives, triplet quenchers, on photosensitized protein damage could be evaluated using this photosensitized reaction system of riboflavin and HSA.

Is the tri-bimaximal mixing accidental?

CERN Document Server

Abbas, Mohammed

2010-01-01

The Tri-bimaximal (TBM) mixing is not accidental if structures of the corresponding leptonic mass matrices follow immediately from certain (residual or broken) flavor symmetry. We develop a simple formalism which allows one to analyze effects of deviations of the lepton mixing from TBM on structure of the neutrino mass matrix and on underlying flavor symmetry. We show that possible deviations from the TBM mixing can lead to strong modifications of the mass matrix and strong violation of the TBM mass relations. As a result, the mass matrix may have an "anarchical" structure with random values of elements or it may have some symmetry which differs from the TBM symmetry. Interesting examples include matrices with texture zeros, matrices with certain "flavor alignment" as well as hierarchical matrices with a two-component structure, where the dominant and sub-dominant contributions have different symmetries. This opens up new approaches to understand the lepton mixing.

External hazards in the PRA of Olkiluoto 1 and 2 NPP units - Accidental oil spills

International Nuclear Information System (INIS)

Tunturivuori, Lasse

2014-01-01

Oil transports in Finnish territorial waters have increased significantly during the last 10 years. The Gulf of Finland is at this moment a very important route of oil being transported from Russia to the Western Europe. Although the number of accidental oil spills is decreasing in amount and in size, there is a growing concern of their effects to nuclear power plants (NPPs). The amounts of oil transported on the Gulf of Bothnia are much smaller than on the Gulf of Finland. However, accidental oil spills have occurred also there, the size and amount of which are smaller, though. Accidental oil spills are often a result of grounding of a ship or collision of two ships, and often occur during harsh weather conditions like storm or dense fog. However, also coastal oil depots may break, the oil of which may spread over wide distances on the sea. The modelling of initiating events resulting from accidental oil spills includes oil spill response actions performed by the regional rescue services, alarming of the oil spill by the emergency response centre to the NPP rescue services and spill response by the NPPs rescue services. It is unclear what the consequences are if drifted oil would enter the coolant water tunnels. The effect of different oil types to the operation of the safety-related service water systems and components are being assessed. In the ultimate case, an oil spill would clog the inlet channels thus failing the ultimate heat sink of the NPP units. The licensee is evaluating what is the optimal way to operate the NPP units in the case that an oil slick is threatening the plant to ensure reactor core cooling and RHR. The continued operation of, and especially the cooling of, at least one auxiliary feedwater pump is critical in the mitigation of the initiating event. Strategies, like reversing the water flow of the cooling water channels or closing of the cooling water channels, are being evaluated. (authors)

Damage analysis. Product improvement through damage analysis; Schadensanalyse. Produktverbesserung durch Schadensanalyse

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the 37th VDI annual meeting from 19th to 20th May, 2011 in Wuerzburg (Federal Republic of Germany) the following lectures and posters were presented: (1) Malpractice of material processing and heat processing of large gear wheels (P. Sommer); (2) Damages by faulty heat treatment - Case studies: Glow testing at a heat exchanger and wheel breakage of a high-strength screw connection (A. Thomas); (3) Crack formation in pole end plates of high-performance generators of a pumped-storage power plant - Causes and possibilities of remedy (J. Kinder); (4) Grind burn inspection for damage prevention at wind turbine gearboxes - Use of different processes for the investigation of peripheral-zone properties of case-hardened components (T. Griggel); (5) Damage inspection in coal mines using products from the degradation process as an example - damage - inspection - solution: This is the working method of the certification body (C. Kleine-Hegermann); (6) Damages at the sealing rings - Causes of the failure at radial shaft rings (K. Marchetti); (7) Thermal analyses at faulty plastic components (O. Jacobs); (8) Application of the micro computer tomography at damages of fibre-reinforced materials (H. Dinnebier); (9) The significance of 'material defects' from the view of lay people, lawyers and engineers - 'Material defect' in the literature, set of rules and expert opinion (C. Klinger); (10) Material defects from a legal view (P. Henseler); (11) Significance of material defects from the view of an engineering insurer (C. Harden); (12) Wear analyses by means of RNT and non-destructive surface analytics (K. Poehlmann); (13) Damages by means of non-metallic inclusions using ICE 3 as an example - Significance and localisation of single non-metallic inclusions in large components (D. Bettge); (14) Cathodic corrosion protection of pipeline steels (H.-G. Schoeneich); (15) Non-destructive and destructive investigations when assessing damages of corrosion at a

UV-B component of sunlight causes measurable damage in field-grown maize (Zea mays L.): developmental and cellular heterogeneity of damage and repair

International Nuclear Information System (INIS)

Stapleton, A.E.; Thornber, C.S.; Walbot, V.

1997-01-01

Ultraviolet radiation has diverse morphogenetic and damaging effects on plants. The end point of damage is reduced plant growth, but in the short term UV radiation damages specific cellular components. We measured cyclobutane pyrimidine dimers in maize DNA from plants grown in natural solar radiation. Green maize tissues had detectable DNA damage, roots had less damage, and anthers had much more damage than green leaves. This heterogeneity in damage levels may reflect differences in dose received or in damage repair. The architecture of green tissues had no measurable effects on DNA damage levels, as leaf sheath and leaf blade were equivalent. We observed a slight increase in damage levels in plants sampled at the end of the day, but there was no accumulation of damage over the growing season. We measured photoreactivation, and found substantial levels of this light-dependent repair in both the epidermis and inner cell layers of leaves, and in all organelles that contain DNA – the nucleus, chloroplasts and mitochondria. We conclude that maize has efficient mechanisms for photo repair of daily UV-induced DNA damage that prevent accumulation

Accidental cut-throat injuries from the broken windshield of an auto rickshaw: Two unusual cases.

Science.gov (United States)

Swain, Rajanikanta; Dhaka, Shivani; Sharma, Munish; Bakshi, Mantaran Singh; Murty, O P; Sikary, Asit Kumar

2018-01-01

Accidental cut-throat injuries are extremely rare and usually involve a sharp-edged weapon. In this paper, two cases of a cut-throat wound to two auto-rickshaw drivers are presented where the broken windshield of the auto-rickshaws was responsible for the wounds. In both the cases, fatal incised wounds were present over the neck, cutting the soft tissue along with the major vessels. The death occurred due to exsanguination caused by neck-vessel injury in one case and trachea along with neck-vessel injury in the second case. Although the wounds on the neck initially suggested homicide, they were found to have occurred accidentally as a result of a road traffic accident involving a head-on collision of auto rickshaws. The injuries were inflicted by the shattered glass of the windshield.

Method and apparatus for controlling accidental releases of tritium

International Nuclear Information System (INIS)

Galloway, T.R.

1980-01-01

An improvement in a tritium control system based on a catalytic oxidation reactor is provided wherein accidental releases of tritium into room air are controlled by flooding the catalytic oxidation reactor with hydrogen when the tritium concentration in the room air exceeds a specified limit. The sudden flooding with hydrogen heats the catalyst to a high temperature within seconds, thereby greatly increasing the catalytic oxidation rate of tritium to tritiated water vapor. Thus, the catalyst is heated only when needed. In addition to the heating effect, the hydrogen flow also swamps the tritium and further reduces the tritium release

Method and apparatus for controlling accidental releases of tritium

Science.gov (United States)

Galloway, Terry R. [Berkeley, CA

1980-04-01

An improvement in a tritium control system based on a catalytic oxidation reactor wherein accidental releases of tritium into room air are controlled by flooding the catalytic oxidation reactor with hydrogen when the tritium concentration in the room air exceeds a specified limit. The sudden flooding with hydrogen heats the catalyst to a high temperature within seconds, thereby greatly increasing the catalytic oxidation rate of tritium to tritiated water vapor. Thus, the catalyst is heated only when needed. In addition to the heating effect, the hydrogen flow also swamps the tritium and further reduces the tritium release.

BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress

Directory of Open Access Journals (Sweden)

Jian Wang

2014-01-01

Full Text Available The present study was to investigate whether a magnolia extract, named BL153, can prevent obesity-induced liver damage and identify the possible protective mechanism. To this end, obese mice were induced by feeding with high fat diet (HFD, 60% kcal as fat and the age-matched control mice were fed with control diet (10% kcal as fat for 6 months. Simultaneously these mice were treated with or without BL153 daily at 3 dose levels (2.5, 5, and 10 mg/kg by gavage. HFD feeding significantly increased the body weight and the liver weight. Administration of BL153 significantly reduced the liver weight but without effects on body weight. As a critical step of the development of NAFLD, hepatic fibrosis was induced in the mice fed with HFD, shown by upregulating the expression of connective tissue growth factor and transforming growth factor beta 1, which were significantly attenuated by BL153 in a dose-dependent manner. Mechanism study revealed that BL153 significantly suppressed HFD induced hepatic lipid accumulation and oxidative stress and slightly prevented liver inflammation. These results suggest that HFD induced fibrosis in the liver can be prevented partially by BL153, probably due to reduction of hepatic lipid accumulation, inflammation and oxidative stress.

Suggested Methods for Assessment of Accidental External Exposure and Internal Contamination of Workers and their Medical Management

International Nuclear Information System (INIS)

Mahmoud, K.A.; Morsy, Samira M.; Hanna, I.R.A.; Hafez, M.B.; Mohamed, H.O.; Jahns, E.; Saied, F.I.A.

1969-01-01

Certain assumptions are given for the amount of fission products released from a research reactor after the occurrence of an accident. The size and location of radioactive cloud are assumed, and the corresponding external and internal exposures of workers are computed. A method is suggested for assessment of accidental external radiation dose based on experimental studies performed on the changes of quenching effect of plasma or sera as a.result of whole- body gamma-radiation ranging from 25-200 rems. For assessment of accidentally internally incorporated gamma emitters we suggest the standard chair whole-body counter technique which was found to detect reliably 1/100 of the maximum permissible body burden within eight minutes. It was also suggested that a separation method based on the use of absorption phenomena observed for Sephadex (gel resin) can be applied for quick determination of gross alpha activity in urine. For management of accidentally exposed workers to radiation doses of a lethal or sublethal nature, bone-marrow transplantation therapy and blood component therapy in sterile rooms is discussed in the light of experience gained from treatment of leukaemia with intensive chemotherapy. (author)

Accidental nuclear excursion Recuplex operation 234-5 facility. Final report: Date of incident: April 7, 1962

Energy Technology Data Exchange (ETDEWEB)

1962-08-01

On Saturday morning, April 7, 1962, at about 1059 Armed Forces time, an accidental nuclear excursion occurred in the plutonium waste recovery facility (Recuplex) of the 234-5 Building. This excursion did not result in any mechanical damage or spread of contamination. Three employees of the General Electric Company received overexposures to gamma and neutron radiation. None were fatally exposed; in each case the overexposure was recognized promptly, and following medical observation and testing the men were released to return to work. In compliance with AEC Manual Chapter 0703, an AEC-HAPO committee composed of two AEC employees and five General Electric employees was appointed by the Manger, HOO, with the concurrence of the General Manager, HAPO, to conduct an investigation of the incident. The committee`s purpose was to determine the cause, nature, and extent of the incident, and recommend action to be taken by others to minimize or preclude future incidents of this magnitude. A study of operating practices and operating conditions that appeared to exist prior to, during, and subsequent to the accident was made by the committee. The committee believes that this report provides sufficient information to answer questions which may arise as a result of the criticality incident except those relating to its cause.

Toxic vapor concentrations in the control room following a postulated accidental release

International Nuclear Information System (INIS)

Wing, J.

1979-05-01

An acceptable method is presented for calculating the vapor concentrations in a control room as a function of time after a postulated accidental release. Included are the mathematical formulas for computing the rates of vaporization and evaporation of liquid spills, the vapor dispersion in air, and the control room air exchange. A list of toxic chemicals and their physical properties is also given

Modelling accidental releases of carbon 14 in the environment: application as an excel spreadsheet

International Nuclear Information System (INIS)

Le Dizes, S.; Tamponnet, C.

2004-01-01

An application as an Excel spreadsheet of the simplified modelling approach of carbon 14 transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the one-pool model (organic carbon) that was developed estimates the concentration of carbon 14 within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of carbon 14 in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of carbon 14 in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)

Areva - Environmental Policy 2014-2016

International Nuclear Information System (INIS)

2014-01-01

Areva supplies advanced technology solutions for power generation with less carbon. Its expertise and unwavering insistence on safety, security, transparency and ethics are setting the standard, and its responsible development is anchored in a process of continuous improvement. Ranked first in the global nuclear power industry, Areva's unique integrated offering to utilities covers every stage of the fuel cycle, nuclear reactor design and construction, and operating services. The group is also expanding in renewable energies - wind, bio-energy, solar, energy storage - to become a European leader in this sector. With these two major offers, Areva's 46,000 employees are helping to supply ever safer, cleaner and more economical energy to the greatest number of people. The 6 commitments of Areva's environmental policy are: 1. Maintain and develop a shared culture for the prevention of environmental risks; 2. Improve the design of our installations taking into account their entire life cycle; 3. Strengthen the prevention and control of accidental technological risks; 4. Prevent risks linked to ageing of installations and accidental spillage; 5. Strengthen the prevention and control of chronic health risks; 6. Manage the environmental footprint of our activities to prevent damages to biodiversity. A graphics summarises Areva's 2016 environmental footprint objectives

Polyamines contribute to salinity tolerance in the symbiosis Medicago truncatula-Sinorhizobium meliloti by preventing oxidative damage.

Science.gov (United States)

López-Gómez, Miguel; Hidalgo-Castellanos, Javier; Muñoz-Sánchez, J Rubén; Marín-Peña, Agustín J; Lluch, Carmen; Herrera-Cervera, José A

2017-07-01

Polyamines (PAs) such as spermidine (Spd) and spermine (Spm) are small ubiquitous polycationic compounds that contribute to plant adaptation to salt stress. The positive effect of PAs has been associated to a cross-talk with other anti-stress hormones such as brassinosteroids (BRs). In this work we have studied the effects of exogenous Spd and Spm pre-treatments in the response to salt stress of the symbiotic interaction between Medicago truncatula and Sinorhizobium meliloti by analyzing parameters related to nitrogen fixation, oxidative damage and cross-talk with BRs in the response to salinity. Exogenous PAs treatments incremented the foliar and nodular Spd and Spm content which correlated with an increment of the nodule biomass and nitrogenase activity. Exogenous Spm treatment partially prevented proline accumulation which suggests that this polyamine could replace the role of this amino acid in the salt stress response. Additionally, Spd and Spm pre-treatments reduced the levels of H 2 O 2 and lipid peroxidation under salt stress. PAs induced the expression of genes involved in BRs biosynthesis which support a cross-talk between PAs and BRs in the salt stress response of M. truncatula-S. meliloti symbiosis. In conclusion, exogenous PAs improved the response to salinity of the M. truncatula-S. meliloti symbiosis by reducing the oxidative damage induced under salt stress conditions. In addition, in this work we provide evidences of the cross-talk between PAs and BRs in the adaptive responses to salinity. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Boring crustaceans damage polystyrene floats under docks polluting marine waters with microplastic.

Science.gov (United States)

Davidson, Timothy M

2012-09-01

Boring isopods damage expanded polystyrene floats under docks and, in the process, expel copious numbers of microplastic particles. This paper describes the impacts of boring isopods in aquaculture facilities and docks, quantifies and discusses the implications of these microplastics, and tests if an alternate foam type prevents boring. Floats from aquaculture facilities and docks were heavily damaged by thousands of isopods and their burrows. Multiple sites in Asia, Australia, Panama, and the USA exhibited evidence of isopod damage. One isopod creates thousands of microplastic particles when excavating a burrow; colonies can expel millions of particles. Microplastics similar in size to these particles may facilitate the spread of non-native species or be ingested by organisms causing physical or toxicological harm. Extruded polystyrene inhibited boring, suggesting this foam may prevent damage in the field. These results reveal boring isopods cause widespread damage to docks and are a novel source of microplastic pollution. Copyright © 2012 Elsevier Ltd. All rights reserved.

Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage

Directory of Open Access Journals (Sweden)

Guan-gui Chen

2015-01-01

Full Text Available Polyethyleneimine-polyethylene glycol (PEI-PEG, a novel nanocarrier, has been used for transfection and gene therapy in a variety of cells. In our previous study, we successfully carried out PEI-PEG-mediated gene transfer in spiral ganglion cells. It remains unclear whether PEI-PEG could be used for gene therapy with X-linked inhibitor of apoptosis protein (XIAP in the inner ear. In the present study, we performed PEI-PEG-mediated XIAP gene transfection in the cochlea of Sprague-Dawley rats, via scala tympani fenestration, before daily cisplatin injections. Auditory brainstem reflex tests demonstrated the protective effects of XIAP gene therapy on auditory function. Immunohistochemical staining revealed XIAP protein expression in the cytoplasm of cells in the spiral ganglion, the organ of Corti and the stria vascularis. Reverse transcription-PCR detected high levels of XIAP mRNA expression in the cochlea. The present findings suggest that PEI-PEG nanocarrier-mediated XIAP gene transfection results in XIAP expression in the cochlea, prevents damage to cochlear spiral ganglion cells, and protects hearing.

[Accidental injection of sodium hypochlorite in inferior alveolar nerve block anesthesia].

Science.gov (United States)

Hongyan, Li; Jian, Xu; Baorong, Zhang; Yue, Jia; Minhua, Liu; Yilang, Luo; Jing, Zhao

2016-12-01

Sodium hypochlorite (NaClO) has been widely used in clinical practice as one of the most efficient root canal irrigants. Its properties include broad-spectrum antimicrobial activity and ability to dissolve necrotic tissues. However, when used improperly, NaClO can cause a series of adverse reactions, such as mucosal inflammation, irritation, or injury. This paper presents a case of accidental injection of NaClO in inferior alveolar nerve block anesthesia.

El recuerdo de los accidentes de tráfico: Memoria de los testigos

OpenAIRE

Diges Junco, Margarita; Manzanero, Antonio L.

1995-01-01

En este trabajo se trata la recogida de datos subjetivos originados por las personas presentes en el accidente, una cuestión de vital importancia en la investigación de éstos y cuya exactitud depende de dos factores principales: la honestidad y la memoria de la persona que los proporciona.

Damage Atlas for Photographic materials

Directory of Open Access Journals (Sweden)

Kristel Van Camp

2010-11-01

Full Text Available La conservation des documents photographiques peut nécessiter des interventions préventives ou curatives. Ce choix est guidé par leur état de conservation. Une meilleure connaissance des détériorations est donc cruciale. Le répertoire présenté ici essaie de les classifier selon des caractéristiques spécifiques et leur niveau de gravité. Les différents types de dégradation sont illustrés et décrits avec une terminologie précise. L’auteur propose en regard de ceux-ci l’intervention qui semble la plus appropriée. Ce répertoire s’adresse à toutes les personnes concernées par la photographie, qu’ils soient dans le milieu de la conservation ou dans le domaine artistique, dans les musées ou dans les archives. In order to rescue a damaged photographic object, preventive or conservative actions are needed. Knowing the specific characteristics of different types of damage is crucial. A damage atlas can provide these characteristics. With this atlas the damage can be recognised and appropriate actions can be taken. This damage atlas offers a first attempt to such a characterisation in the field of photography. The damage atlas contains images and the necessary information about damage on photographic material. The atlas with special annotations about the terminology and the grade of the damage is meant for everybody who works with photographic material, as well in museums as in archives.

Self-healing Coatings for an Anti-corrosion barrier in Damaged Parts

International Nuclear Information System (INIS)

Cho, Soo Hyoun

2009-01-01

Polymer coatings are commonly applied to metal substrates to prevent corrosion in aggressive environments such as high humidity and under salt water. Once the polymer coating has been breached, for example due to cracking or scratches, it loses its effectiveness, and corrosion can rapidly propagate across the substrate. The self-healing system we will describe prevents corrosion by healing the damage through a healing reaction triggered by the actual damage event. This self-healing coating solution can be easily applied to most substrate materials, and our dual-capsule healing system provides a general approach to be compatible with most common polymer matrices. Specifically, we expect an excellent anti-corrosion property of the self-healing coatings in damaged parts coated on galvanized metal substrates.

Nuclear power plants and prevention of sanitary risks

International Nuclear Information System (INIS)

Delpla, M.

1977-01-01

The radioprotection specialists know that people irradiation can cause fearful diseases even to their descendance. So they wanted to predict the upper limit of the damage that could be caused by irradiations at the limits of radioprotection doses of IRCP standards recommended for the whole population. For their previsional calculations, they admitted the proportionality between the most fearful risks and the accumulated individual dose, whatever the time is. According to such an hypothesis, the previsional damage would be proportional to the population dose. Observed damages on accidentally or experimentally irradiated population will be compared to the previsional damage, calculated from the values generally admitted for the risks. The author will consider the risks which are usually taken in account in the protection of people against the hazard of nuclear power plants such as: leukemia, thyroid cancer. Such comparisons will allow to propose, in the field of radioprotection: to abandon the hypothesis of proportionality between the risk and the dose; to admit a practical threshold dose for each of the most fearful effects; to admit the same radiation protection standards for eveyone; to try to interpret facts until then unnoticed, or when they have been seen, called 'paradoxical'; these facts may be due to the stimulating effect of a suitable dose of ionizing radiation. Such a stimulating effect is well known by the radiologists, but some of the latter are afraid of secondary delate effects. This new field of research may be as useful to radiotherapy as to radioprotection [fr

Follow-up study of abnormal biological indicators and gene expression in the peripheral blood of three accidentally exposed persons

International Nuclear Information System (INIS)

Chi Cuiping; Wang Haiyan; Wei Jinping; Guo Jianping; Li Shufang; Tian Rong; Guo Fengling; Liu Huifang

2013-01-01

In order to identify biomarkers for early diagnosis and/or for therapeutic targets in the delayed health effects of ionizing radiation, we analyzed the subgroups of lymphocytes, serum protein levels and gene expression profiles in the peripheral blood of three 60 Co γ-ray accidentally exposed persons during the three years after irradiation. Flow cytometry analyses and agarose gel electrophoresis were applied to investigate the subgroups of lymphocytes and the composition of serum proteins, respectively. Gene expression profiling was obtained using a whole genome gene expression chip assay. Both the percentage of CD4+ T lymphocytes and the ratio of Th to Ts were reduced compared with the normal control values. The percentage of albumin decreased whereas beta globulin increased. There were 285 up-regulated and 446 down-regulated genes in irradiated samples relative to the control samples. The expression of KDR, CEACAM8 and OSM was validated by RT-PCR. The majority of the differentially expressed genes encode proteins associated with the immune response, inflammation, oncogenesis, cell structure, oxidative stress, neuro-hormone regulation, reproduction, susceptibility to psychiatric disorders, or transcriptional regulation. We have identified a number of promising novel candidates that have potential for serving as biomarkers for delayed damage. Furthermore, the changes in the immunological indicator CD4+ T cells, and the ratio of CD4+ T to CD8+ T cells may be biomarkers for the prediction of delayed damage by ionizing radiation. The findings of our study are useful for forming a comprehensive understanding of the mechanisms underlying the delayed effects of ionizing radiation. (author)

RENAL DAMAGE WITH MALIGNANT NEOPLASMS

Directory of Open Access Journals (Sweden)

I. B. Kolina

2015-01-01

Full Text Available The relationship between renal damage and malignant neoplasms is one of the most actual problems of the medicine of internal diseases. Very often, exactly availability of renal damage determines the forecast of cancer patients. The range of renal pathologies associated with tumors is unusually wide: from the mechanical effect of the tumor or metastases on the kidneys and/or the urinary tract and paraneoplastic manifestations in the form of nephritis or amyloidosis to nephropathies induced with drugs or tumor lysis, etc. Thrombotic complications that develop as a result of exposure to tumor effects, side effects of certain drugs or irradiation also play an important role in the development of the kidney damage. The most frequent variants of renal damage observed in the practice of medical internists (therapists, urologists, surgeons, etc., as well as methods of diagnosis and treatment approaches are described in the article. Timely and successful prevention and treatment of tumor-associated nephropathies give hope for retaining renal functions, therefore, a higher life standard after completion of anti-tumor therapy. Even a shortterm episode of acute renal damage suffered by a cancer patient must be accompanied with relevant examination and treatment. In the caseof transformation of acute renal damage into the chronic kidney disease, such patients need systematic and weighted renoprotective therapy and correct dosing of nephrotoxic drugs.

Accidental head injuries in children under 5 years of age

International Nuclear Information System (INIS)

Johnson, K.; Fischer, T.; Chapman, S.; Wilson, B.

2005-01-01

AIM: To evaluate the type and nature of head injuries sustained by children under the age of 5 years who present to a busy accident and emergency (A and E) department following an accidental fall. MATERIALS AND METHODS: This study included all children under the age of 5 years, who over an 8-month period were referred to our A and E Department with head injury following an accidental fall. Data were collected regarding the height of the fall, whether or not stairs were involved, the type of surface that the child landed on and the height of the child. This was correlated with any soft-tissue injury or skull fracture. RESULTS: A total of 72 children (aged 4 months to 4.75 years) fulfilled all the criteria for an accidental fall. The heights of the falls ranged from less than 50 cm to over 3 m, with the majority below 1 m. Of the falls, 49 were onto a hard surface and 23 were onto a soft surface. Of the 72 children, 52 had visible evidence of head injury, 35 (71%) of 49 being the result of falls onto hard surfaces and 17 (74%) of 23 onto soft (carpeted) surfaces. There was no significant difference in the type of surface that resulted in a visible head injury. A visible head injury was seen in all children who fell from a height of over 1.5 m and in 95% of children who fell over 1 m. Of the 72 children, 32 (44%) had skull radiographs performed in accordance with established guidelines and 4 (12.5%) were identified as having a fracture. Of the 3 linear parietal fractures 2 were inflicted by falls of just over 1 m (from a work surface) and 1 by a fall of 80 to 90 cm onto the hard-edged surface of a stone fire surround. The 4th was a fracture of the base of skull following a fall from more than 3 m (from a first-storey window). CONCLUSIONS: In the vast majority of domestic accidents children do not suffer significant harm. Skull fractures are rare and probably occur in less than 5% of cases. To cause a skull fracture the fall needs to be from over 1 m or, if from a

Top event prevention analysis: A deterministic use of PRA

International Nuclear Information System (INIS)

Worrell, R.B.; Blanchard, D.P.

1996-01-01

This paper describes the application of Top Event Prevention Analysis. The analysis finds prevention sets which are combinations of basic events that can prevent the occurrence of a fault tree top event such as core damage. The problem analyzed in this application is that of choosing a subset of Motor-Operated Valves (MOVs) for testing under the Generic Letter 89-10 program such that the desired level of safety is achieved while providing economic relief from the burden of testing all safety-related valves. A brief summary of the method is given, and the process used to produce a core damage expression from Level 1 PRA models for a PWR is described. The analysis provides an alternative to the use of importance measures for finding the important combination of events in a core damage expression. This application of Top Event Prevention Analysis to the MOV problem was achieve with currently available software

Coincidence-counting corrections for accidental coincidences, set dead time and intrinsic dead time

International Nuclear Information System (INIS)

Wyllie, H.A.

1998-01-01

An equation is derived for calculating the radioactivity of a source from the results of coincidence counting, taking into account dead-time losses and accidental coincidences. The corrections allow for the extension of the set dead time in the p channel by the intrinsic dead time. Experimental verification shows improvement over a previous equation. (author)

Accidental Discovery of Information on the User-Defined Social Web: A Mixed-Method Study

Science.gov (United States)

Lu, Chi-Jung

2012-01-01

Frequently interacting with other people or working in an information-rich environment can foster the "accidental discovery of information" (ADI) (Erdelez, 2000; McCay-Peet & Toms, 2010). With the increasing adoption of social web technologies, online user-participation communities and user-generated content have provided users the…

An advanced model for spreading and evaporation of accidentally released hazardous liquids on land

NARCIS (Netherlands)

Trijssenaar-Buhre, I.J.M.; Sterkenburg, R.P.; Wijnant-Timmerman, S.I.

2009-01-01

Pool evaporation modelling is an important element in consequence assessment of accidentally released hazardous liquids. The evaporation rate determines the amount of toxic or flammable gas released into the atmosphere and is an important factor for the size of a pool fire. In this paper a

An advanced model for spreading and evaporation of accidentally released hazardous liquids on land

NARCIS (Netherlands)

Trijssenaar-Buhre, I.J.M.; Wijnant-Timmerman, S.L.

2008-01-01

Pool evaporation modelling is an important element in consequence assessment of accidentally released hazardous liquids. The evaporation rate determines the amount of toxic or flammable gas released into the atmosphere and is an important factor for the size of a pool fire. In this paper a

War damages and reconstruction of Peruca dam

International Nuclear Information System (INIS)

Nonveiller, E.; Sever, Z.

1999-01-01

The paper describes the heavy damages caused by blasting in the Peruca rockfill dam in Croatia in January 1993. Complete collapse of the dam by overtopping was prevented through quick action of the dam owner by dumping clayey gravel on the lowest sections of the dam crest and opening the bottom outlet of the reservoir, thus efficiently lowering the water level. After the damages were sufficiently established and alternatives for restoration of the dam were evaluated, it was decided to construct a diaphragm wall through the damaged core in the central dam part as the impermeable dam element and to rebuild the central clay core at the dam abutments. Reconstruction works are described

Creatin-kinase elevation after accidental ingestion of almotriptan in an 18-month-old girl.

Science.gov (United States)

Castagno, E; Lupica, M; Viola, S; Savino, F; Miniero, R

2014-02-01

Few studies have been published to demonstrate tolerability and efficacy of almotriptan in adolescents and children with migraine, particularly in the first years of life, though preliminary results are favorable. We report the case of an 18-month-old infant with elevation of serum levels of creatin-kinase after the accidental ingestion of almotriptan. A previously healthy 18-month-old girl (weight: 13 kg) was admitted to our Department four hours after the accidental ingestion of 6.25 mg of almotriptan (0.48 mg/kg), without any specific symptom. The performed investigations showed high serum levels of creatin-kinase (CK) (527 IU/L; normal values: 24-170 IU/L). Transaminase, creatinine, aldolase, myoglobin and troponin T serum levels were normal. The electrocardiogram proved negative. Initial management consisted of parenteral rehydration with saline solution. CK levels lowered significantly at 12 hours (455 IU/L) and at 65 hours (188 IU/L) after the ingestion. No symptoms were observed before discharge and on follow-up.

Factores asociados con la presentación de accidentes laborales en veterinarios zootecnistas del departamento de Boyacá (Colombia

Directory of Open Access Journals (Sweden)

Michael López Cepeda

2014-01-01

Full Text Available Objetivo: Cuantificar los Accidentes Laborales (AL e identificar los factores asociados a su presentación en veterinarios zootecnistas del departamento de Boyacá.Materiales y métodos: Este es un estudio observacional de tipo transversal que permitió cuantificar los accidentes laborales (AL en médicos veterinarios zootecnistas (MVZ con matrícula profesional vigente y ejercicio profesional en el departamento de Boyacá. Se calculó el tamaño muestral (n, con una frecuencia estimada de accidentes del 75 %, un error absoluto del 5 % y un nivel de confianza del 95 %, ajustándolo por el tamaño de la población (N. El diseño muestral fue aleatorio simple. El análisis estadístico incluyó correlación de Spearman, X2 y regresión logística. Los análisis se efectuaron con SPSS®. Resultados: El promedio de edad fue de 33,8±8,2 años. El 91,7 % de los encuestados tuvo por los menos un AL que involucró la presencia de animales, agujas, bisturí y/o un medio de movilización al lugar de trabajo. Las lesiones más frecuentes producto de los AL fueron: heridas punzantes y cortantes, contusiones, hematomas, reacciones alérgicas. Los hombres presentaron 3,086 veces más probabilidades de sufrir este tipo de accidentes que las mujeres (p=0,017. El trabajo con grandes animales es la especialidad veterinaria a la cual se dedicaba la mayor proporción (67,1 % de encuestados. En el trabajo con pequeños animales, los accidentes de mayor presentación fueron: atropellamiento por animales, punzada, corte, mordedura, esfuerzo físico y caída/resbalón. Conclusiones: Los resultados obtenidos condicionan y procuran revaluar aspectos ocupacionales en aras de minimizar los riesgos en la actividad rural de Boyacá.

The influence of season of the year on the predicted agricultural consequences of accidental releases of radionuclides to atmosphere

International Nuclear Information System (INIS)

Simmonds, J.R.

1985-02-01

In Europe, because of the seasonal nature of agricultural practices, the consequences for agriculture of an accidental release of radioactive materials to atmosphere are likely to vary depending upon the time of year when the release occurs. The quantification of this variation is complicated by the need to take into account the introduction of countermeasures to restrict the radiation exposure from ingestion of contaminated foods, and by the presence in accidental releases of radionuclides which persist over several seasons. In this study, the effect on agricultural consequences of accidental releases occurring at different times of the year is examined. The consequences are expressed in terms of the amount of produce affected by restrictions on food supplies and the collective radiation dose from ingestion of food. The investigation has been carried out for three hypothetical releases representing a range of releases postulated for pressurised water reactors (PWRs). The effect of season of the year was determined for accidental releases occurring both in a single, defined set of meteorological conditions and for a range of possible meteorological conditions. For the main part of the study, consideration was limited to agricultural production in the UK only, but the effect of extending the analysis beyond the UK boundary was also considered. The results of the study show that considerable variation can occur in agricultural consequences following an accidental release at different times of the year. For the larger releases considered, this variation is reduced due to the effect of the introduction of countermeasures, particularly when consideration is limited to the UK only. Seasonal variation tends to be greater for the results of a deterministic analysis, which uses a single set of constant meteorological conditions, than for the results of a full probabilistic assessment. From the results presented here it is also seen that for many applications of

Damage on sliding bearings of internal combustion engines. Damage patterns, causes, prevention; Schaeden an Gleitlagern von Verbrennungsmotoren. Erscheinungsbilder, Ursachen, Vermeidung

Energy Technology Data Exchange (ETDEWEB)

Ederer, U.G. [Miba Gleitlager GmbH, Laakrichen (Austria)

2005-07-01

Bearing failures are consequences of system deficiencies which cause an inadequate function of the hydrodynamic action and, thereby, too high a friction, at least locally. The bearing overheats, what ultimately leads to its destruction and that of adjacent components. These 'consequential damages' are frequently severe. We identify, therefore, early stages of malfunction, already as 'bearing damage'. In this condition, a diagnosis and remedial measures to avoid total destruction are possible. Typical bearing conditions, possible causes and remedies are described herein. (orig.)

Case studies on the use of the 'risk matrix' approach for accident prevention in radiotherapy

International Nuclear Information System (INIS)

Dumenigo, Cruz; Vilaragut, Juan J.; Soler, Karen; Cruz, Yoanis; Batista, Fidel; Morales, Jorge L.; Perez, Adrian; Farlane, Teresa Mc.; Guerrero, Mayrka

2010-01-01

External beam radiotherapy is the only practice during which humans are directly exposed to a radiation beam to receive high doses. Accidental exposures have occurred throughout the world, thus showing the need for systematic safety assessments, capable to identify preventive measures and to minimize consequences of accidental exposure. The 'risk matrix' approach is a semi quantitative method to evaluate the likelihood and the severity of events by means of a scale, and defines acceptability criteria on the basis of the risk. For each accident sequence identified, the following questions come up: how often is it?, how severe are the consequences? and, what safety measures should be taken to prevent it?. From these answers we can obtain the resulting risk by using the 'Risk Matrix' table. In this study we have used this method to conduct the study in 3 cases (real radiotherapy departments). The case study identified the major weaknesses in radiotherapy service and proposed measures to reduce the risk of accidents. The method is practical and it could be applied in hospitals. This approach allows regulators to improve the quality of their inspections and the rigor of the assessments made to grant the operating license to the entities working with radiotherapy. (author)

Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice

Directory of Open Access Journals (Sweden)

Po-Yuan Wu

2017-10-01

Full Text Available Chronic ultraviolet (UV exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice. The erythema index (a* values and transepidermal water loss were evaluated to assess skin damage, and immunohistochemical staining was conducted to elucidate the photoprotective mechanism of fisetin. The results revealed that the topical application of fisetin reduced UVB-induced increase in the a* value and wrinkle formation. In addition, fisetin inhibited epidermal hyperplasia and increased the collagen content in the dermis. Fisetin exerted photoprotective activity by inhibiting the expression of MMP-1, MMP-2, and cyclooxygenase-2 and increasing the expression of nuclear factor erythroid 2-related factor. Furthermore, fisetin increased the expression of filaggrin to prevent UVB-induced barrier function disruption. Altogether, the present results provide evidence of the effects and mechanisms of fisetin’s antiphotodamage and antiphotoinflammation activities.

Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice.

Science.gov (United States)

Wu, Po-Yuan; Lyu, Jia-Ling; Liu, Yi-Jung; Chien, Ting-Yi; Hsu, Hao-Cheng; Wen, Kuo-Ching; Chiang, Hsiu-Mei

2017-10-10

Chronic ultraviolet (UV) exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs) activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice. The erythema index (a* values) and transepidermal water loss were evaluated to assess skin damage, and immunohistochemical staining was conducted to elucidate the photoprotective mechanism of fisetin. The results revealed that the topical application of fisetin reduced UVB-induced increase in the a* value and wrinkle formation. In addition, fisetin inhibited epidermal hyperplasia and increased the collagen content in the dermis. Fisetin exerted photoprotective activity by inhibiting the expression of MMP-1, MMP-2, and cyclooxygenase-2 and increasing the expression of nuclear factor erythroid 2-related factor. Furthermore, fisetin increased the expression of filaggrin to prevent UVB-induced barrier function disruption. Altogether, the present results provide evidence of the effects and mechanisms of fisetin's antiphotodamage and antiphotoinflammation activities.

Patterns of damage in the mature neonatal brain

International Nuclear Information System (INIS)

Triulzi, Fabio; Parazzini, Cecilia; Righini, Andrea

2006-01-01

Patterns of damage in the mature neonatal brain can be subdivided into focal, multifocal and diffuse. The main cause of diffuse brain damage in the term newborn is hypoxic-ischaemic encephalopathy (HIE). HIE is still the major recognized perinatal cause of neurological morbidity in full-term newborns. MRI offers today the highest sensitivity in detecting acute anoxic injury of the neonatal brain. Conventional acquisition techniques together with modern diffusion techniques can identify typical patterns of HIE injury, even in the early course of the disease. However, even though highly suggestive, these patterns cannot be considered as pathognomonic. Perinatal metabolic disease such as kernicterus and severe hypoglycaemia should be differentiated from classic HIE. Other conditions, such as infections, non-accidental injury and rarer metabolic diseases can be misinterpreted as HIE in their early course when diffuse brain swelling is still the predominant MRI feature. Diffusion techniques can help to differentiate different types of diffuse brain oedema. Typical examples of focal injuries are arterial or venous infarctions. In arterial infarction, diffusion techniques can define more precisely than conventional imaging the extent of focal infarction, even in the hyperacute phase. Moreover, diffusion techniques provide quantitative data of acute corticospinal tract injury, especially at the level of the cerebral peduncles. Venous infarction should be suspected in every case of unexplained cerebral haematoma in the full-term newborn. In the presence of spontaneous bleeding, venous structures should always be evaluated by MR angiography. (orig.)

Patterns of damage in the mature neonatal brain

Energy Technology Data Exchange (ETDEWEB)

Triulzi, Fabio; Parazzini, Cecilia; Righini, Andrea [Children' s Hospital ' ' Vittore Buzzi' ' , Departments of Radiology and Neuroradiology, Milan (Italy)

2006-07-15

Patterns of damage in the mature neonatal brain can be subdivided into focal, multifocal and diffuse. The main cause of diffuse brain damage in the term newborn is hypoxic-ischaemic encephalopathy (HIE). HIE is still the major recognized perinatal cause of neurological morbidity in full-term newborns. MRI offers today the highest sensitivity in detecting acute anoxic injury of the neonatal brain. Conventional acquisition techniques together with modern diffusion techniques can identify typical patterns of HIE injury, even in the early course of the disease. However, even though highly suggestive, these patterns cannot be considered as pathognomonic. Perinatal metabolic disease such as kernicterus and severe hypoglycaemia should be differentiated from classic HIE. Other conditions, such as infections, non-accidental injury and rarer metabolic diseases can be misinterpreted as HIE in their early course when diffuse brain swelling is still the predominant MRI feature. Diffusion techniques can help to differentiate different types of diffuse brain oedema. Typical examples of focal injuries are arterial or venous infarctions. In arterial infarction, diffusion techniques can define more precisely than conventional imaging the extent of focal infarction, even in the hyperacute phase. Moreover, diffusion techniques provide quantitative data of acute corticospinal tract injury, especially at the level of the cerebral peduncles. Venous infarction should be suspected in every case of unexplained cerebral haematoma in the full-term newborn. In the presence of spontaneous bleeding, venous structures should always be evaluated by MR angiography. (orig.)

Modification of radiation-induced oxidative damage in liposomal and microsomal membrane by eugenol

Energy Technology Data Exchange (ETDEWEB)

Pandey, B.N. [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Lathika, K.M. [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Mishra, K.P. [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India)]. E-mail: kpm@magnum.barc.ernet.in

2006-03-15

Radiation-induced membrane oxidative damage, and their modification by eugenol, a natural antioxidant, was investigated in liposomes and microsomes. Liposomes prepared with DPH showed decrease in fluorescence after {gamma}-irradiation, which was prevented significantly by eugenol and correlated with magnitude of oxidation of phospholipids. Presence of eugenol resulted in substantial inhibition in MDA formation in irradiated liposomes/microsomes, which was less effective when added after irradiation. Similarly, the increase in phospholipase C activity observed after irradiation in microsomes was inhibited in samples pre-treated with eugenol. Results suggest association of radio- oxidative membrane damage with alterations in signaling molecules, and eugenol significantly prevented these membrane damaging events.

Successful Thrombolysis and Spasmolysis of Acute Leg Ischemia after Accidental Intra-arterial Injection of Dissolved Flunitrazepam Tablets

International Nuclear Information System (INIS)

Radeleff, B.; Stampfl, U.; Sommer, C.-M.; Bellemann, N.; Hyhlik-Duerr, A.; Weber, M.-A.; Boeckler, D.; Kauczor, H.-U.

2011-01-01

A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery. A combination of anticoagulation, vasodilatation, and local selective and superselective thrombolysis with urokinase was performed to salvage the leg. As a result of the severe ischemia-induced pain, the patient had to be monitored over the complete therapy period on the intensive care unit with permanent administration of intravenous fluid and analgetics. We describe the presenting symptoms and the interventional technique, and we discuss the recent literature regarding the management of accidental intra-arterial injection of dissolved flunitrazepam tablets.

Non-accidental dettol poisoning in a 3 day old neonate : a rare form ...

African Journals Online (AJOL)

2015-02-26

Feb 26, 2015 ... non-accidental poisoning with dettol® in a neonate. This report presents ... health facility located in Kano city; pregnancy, labour and delivery .... risks undetected as it nearly happened in our index pa- tient. It is equally ... P O, Saliu R O, Adafalu M O. Infanticide in ... hood Non-food poisoning in. Aminu Kano ...

Non-accidental dettol poisoning in a 3 day old neonate : a rare form ...

African Journals Online (AJOL)

In Nigeria, Dettol® Antiseptic Solution poisoning is an uncommon occurrence in all age groups. In a registered child specialist clinic in Kano, a three – day old neonate presented with clinical features believed initially to be due to neonatal seizures and sepsis, but which turned out to be due to non-accidental dettol® ...

Clinical perspectives on osteogenesis imperfecta versus non-accidental injury.

Science.gov (United States)

Pereira, Elaine Maria

2015-12-01

Although non-accidental injuries (NAI) are more common in cases of unexplained fractures than rare disorders such as osteogenesis imperfecta (OI), ruling out OI and other medical causes of fracture is always indicated. The majority of OI patients can be diagnosed with the help of family history, physical examination, and radiographic findings. In particular, there are a few radiological findings which are seen more commonly in NAI than in OI which may help guide clinician considerations regarding the probability of either of these diagnoses. At the same time, molecular testing still merits careful consideration in cases with unexplained fractures without obvious additional signs of abuse. © 2015 Wiley Periodicals, Inc.

PERFORMANCE EVALUATION OF EMPIRICAL MODELS FOR VENTED LEAN HYDROGEN EXPLOSIONS

OpenAIRE

Anubhav Sinha; Vendra C. Madhav Rao; Jennifer X. Wen

2017-01-01

Explosion venting is a method commonly used to prevent or minimize damage to an enclosure caused by an accidental explosion. An estimate of the maximum overpressure generated though explosion is an important parameter in the design of the vents. Various engineering models (Bauwens et al., 2012, Molkov and Bragin, 2015) and European (EN 14994 ) and USA standards (NFPA 68) are available to predict such overpressure. In this study, their performance is evaluated using a number of published exper...

Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage.

Science.gov (United States)

He, Shugui; Ou, Rilan; Wang, Wensheng; Ji, Liyan; Gao, Hui; Zhu, Yuanfeng; Liu, Xiaomin; Zheng, Hongming; Liu, Zhongqiu; Wu, Peng; Lu, Linlin

2018-06-28

Camptosorus sibiricus Rupr (CSR) is a widely used herbal medicine with antivasculitis, antitrauma, and antitumor effects. However, the effect of CSR aqueous extract on B[a]P-initiated tumorigenesis and the underlying mechanism remain unclear. Moreover, the compounds in CSR aqueous extract need to be identified and structurally characterized. We aim to investigate the chemopreventive effect of CSR and the underlying molecular mechanism. A B[a]P-stimulated normal cell model (BEAS.2B) and lung adenocarcinoma animal model were established on A/J mice. In B[a]P-treated BEAS.2B cells, the protective effects of CSR aqueous extract on B[a]P-induced DNA damage and ROS production were evaluated through flow cytometry, Western blot, real-time quantitative PCR, single-cell gel electrophoresis, and immunofluorescence. Moreover, a model of B[a]P-initiated lung adenocarcinoma was established on A/J mice to determine the chemopreventive effect of CSR in vivo. The underlying mechanism was analyzed via immunohistochemistry and microscopy. Furthermore, the new compounds in CSR aqueous extract were isolated and structurally characterized using IR, HR-ESI-MS, and 1D and 2D NMR spectroscopy. CSR effectively suppressed ROS production by re-activating Nrf2-mediated reductases HO-1 and NQO-1. Simultaneously, CSR attenuated the DNA damage of BEAS.2B cells in the presence of B[a]P. Moreover, CSR at 1.5 and 3 g/kg significantly suppressed tumorigenesis with tumor inhibition ratios of 36.65% and 65.80%, respectively. The tumor volume, tumor size, and multiplicity of B[a]P-induced lung adenocarcinoma were effectively decreased by CSR in vivo. After extracting and identifying the compounds in CSR aqueous extract, three new triterpene saponins were isolated and characterized structurally. CSR aqueous extract prevents lung tumorigenesis by exerting dual effects against ROS and DNA damage, suggesting that CSR is a novel and effective agent for B[a]P-induced carcinogenesis. Moreover, by isolating

ANCCLI White Paper V. Nuclear and territories, which roles for the CLIs? Which implication for the population in crisis management and post-accidental management planning?

International Nuclear Information System (INIS)

Delalonde, Jean-Claude; Charre, Jean-Pierre

2017-01-01

This white paper first states a set of fourteen recommendations regarding crisis management planning, post-accidental management planning, waste management, and the roles of CLIs (local information commissions) in crisis and post-accidental management planning. After an introduction which proposes a presentation of roles CLIs could play in the different stage of this planning (preparation, emergency or crisis, post-accidental), and a discussion of concerned territories, this white paper discusses territory zoning (zoning in situation of emergency, in post-accidental situation) and roles of territories and CLIs. The next part addresses the issue of decontamination: pollution and contamination management (territory decontamination, issue of water resources, waste management) and discusses the roles of territories and CLIs on these issues. The third part addresses the issue of support and protection of population regarding different aspects: census, relocation, continuity of public services, continuity of economic activities, food restrictions, medical follow-up and epidemiology, and compensations. The roles of territories and CLIs on these issues are discussed. The fourth part addresses the issues of information and communication in a crisis or post-accidental situation. The fifth part discusses tools and means needed by the CLIs to cope with these situations. Short contributions from different institutions (ASN, IRSN) and members of the ANCCLI are finally proposed

Metabolite damage and repair in metabolic engineering design

Energy Technology Data Exchange (ETDEWEB)

Sun, Jiayi; Jeffryes, James G.; Henry, Christopher S.; Bruner, Steven D.; Hanson, Andrew D.

2017-11-01

The necessarily sharp focus of metabolic engineering and metabolic synthetic biology on pathways and their fluxes has tended to divert attention from the damaging enzymatic and chemical side-reactions that pathway metabolites can undergo. Although historically overlooked and underappreciated, such metabolite damage reactions are now known to occur throughout metabolism and to generate (formerly enigmatic) peaks detected in metabolomics datasets. It is also now known that metabolite damage is often countered by dedicated repair enzymes that undo or prevent it. Metabolite damage and repair are highly relevant to engineered pathway design: metabolite damage reactions can reduce flux rates and product yields, and repair enzymes can provide robust, host-independent solutions. Herein, after introducing the core principles of metabolite damage and repair, we use case histories to document how damage and repair processes affect efficient operation of engineered pathways - particularly those that are heterologous, non-natural, or cell-free. We then review how metabolite damage reactions can be predicted, how repair reactions can be prospected, and how metabolite damage and repair can be built into genome-scale metabolic models. Lastly, we propose a versatile 'plug and play' set of well-characterized metabolite repair enzymes to solve metabolite damage problems known or likely to occur in metabolic engineering and synthetic biology projects.

Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis

Directory of Open Access Journals (Sweden)

Mahmoud Rouabhia

2012-01-01

Full Text Available In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement membrane protein production (laminin 5 and type IV collagen. We thus propose that ECM33 gene/protein represents a novel target for the prevention and treatment of infections caused by Candida.

Condition-Based Maintenance Strategy for Production Systems Generating Environmental Damage

Directory of Open Access Journals (Sweden)

L. Tlili

2015-01-01

Full Text Available We consider production systems which generate damage to environment as they get older and degrade. The system is submitted to inspections to assess the generated environmental damage. The inspections can be periodic or nonperiodic. In case an inspection reveals that the environmental degradation level has exceeded the critical level U, the system is considered in an advanced deterioration state and will have generated significant environmental damage. A corrective maintenance action is then performed to renew the system and clean the environment and a penalty has to be paid. In order to prevent such an undesirable situation, a lower threshold level L is considered to trigger a preventive maintenance action to bring back the system to a state as good as new at a lower cost and without paying the penalty. Two inspection policies are considered (periodic and nonperiodic. For each one of them, a mathematical model and a numerical procedure are developed to determine simultaneously the preventive maintenance (PM threshold L∗ and the inspection sequence which minimize the average long-run cost per time unit. Numerical calculations are performed to illustrate the proposed maintenance policies and highlight their main characteristics with respect to relevant input parameters.

La prevención de accidentes (2

Directory of Open Access Journals (Sweden)

Chinchilla, M.

1966-03-01

Full Text Available Everyone prefers to work in those organizations where their dignity of human beings is respected. One of the most efficient means at the disposal of any firm, to improve the morale of the individual employees, and to establish a spirit of cooperation between the individual and the firm, is to set up a program of accident benefit. It will avoid direct and indirect losses due to working accidents, as analyzed in a previous article, and it will make it possible to improve total performance of each worker, since he will work in a more favorable environment, free from worry about potential danger to his person. It is almost impossible to describe in detail all those items that should be taken into account in a safety program. None the less, and as an indication of their diversity, some sources of danger are mentioned in this chapter, which are closely connected with human safety, such as public curiosity, travelling from one place to another, cleanliness and order.Todas las personas prefieren desempeñar sus tareas en aquellas organizaciones que tienen hacia ellos las consideraciones correspondientes a un ser humano. Uno de los medios más eficaces a disposición de cualquier empresa para elevar la moral del individuo y para crear un lazo de cooperación común entre el individuo y la empresa, es la de llevar a cabo un programa de prevención de accidentes, programa que redundará en el doble fruto: evitar las pérdidas directas e indirectas causadas por los accidentes de trabajo que se detallaron en un trabajo anterior, y conseguir aumentar el rendimiento del operario al hacerle un ambiente más grato por la preocupación que se demuestra hacia su persona. Es casi imposible detallar todos aquellos puntos que se deben tener en cuenta en un programa de seguridad; sin embargo, y como exponente de su diversidad, se señalan en este capítulo algunas causas, que, sin estar ligadas directamente con el trabajo individual, no obstante se encuentran �

Intentional and accidental paracetamol poisoning in childhood – a retrospective analysis

Directory of Open Access Journals (Sweden)

Katarzyna Kominek

2015-04-01

Full Text Available Paracetamol is one of the most commonly used analgesics and antipyretics available without limits as preparations of the OTC group (over the counter drugs. Overdose and poisoning with this drug always brings about the risk of acute hepatic failure. The objective of the study was a retrospective evaluation of patients hospitalized in the Paediatric Clinic during the period 2004–2012 due to poisoning with paracetamol.The analysis covered 44 patients hospitalized in the Paediatric Clinic during 2004–2012 due to poisoning with paracetamol. Patients were divided into three groups: intentional poisonings, accidental poisonings, and drug overdose.During the period of the study, 44 patients aged 2.1–17.1, poisoned with paracetamol, were hospitalized. Among these patients there were 30 (68.2% cases of intentional poisonings, 10 (22.7% of accidental poisonings, and only 4 patients (9.1% were children hospitalized after a paracetamol overdose. The majority of patients in all groups were females (93.3%.Paracetamol intoxication may occur after exceeding a single allowable dose, in the case of intentional poisoning, more rarely after exceeding the daily dose, in the case of intense pain complaints, or in the treatment of persistent fever.Based on the analysis performed, an increase was observed in the frequency of poisoning with paracetamol, especially intentional poisoning. Unlimited access to paracetamol as an OTC drug should be reconsidered.

Accidentes atendidos en un área básica de salud de girona, españa

Directory of Open Access Journals (Sweden)

Soriano Suárez Elena

2002-01-01

Full Text Available Fundamentos: Los accidentes constituyen una patología poco estudiada en el ámbito de la Atención Primaria. Son una de las consultas más frecuentes en los servicios de urgencias y los Centros de Atención Primaria realizan la primera asistencia a la mayoría de los accidentados. Conocer la incidencia y las características clínico-epidemiológicas de los accidentes atendidos en una Área Básica de Salud puede aportar información sobre cuáles pueden ser susceptibles de actividades de prevención. Métodos: Diseño: estudio descriptivo. Emplazamiento: atención primaria. Muestra: todos los pacientes (389 que fueron atendidos por accidente en el Centro de Atención Primaria, entre octubre-98 y mayo-99. Variables: edad, sexo, lugar del accidente, tipo de lesión, localización, agentes implicados, intencionalidad, pruebas complementarias, tratamiento y derivación. Análisis estadísticos: estimación de medias, desviación estándar, estimación de proporciones e intervalos de confianza del 95%. Resultados: Incidencia: 4,1% (IC95%: 3,7-4,5%. Sexo: varones 59% (IC95%:54,2-64% y mujeres 40,9% (IC95%: 36-45,8%. Edad: menores de 20 años, el 50,4% (IC95%:45,4-55,4%;.Actividad de mayor accidentalidad: ocio 24,4% (IC95%: 20,2-28,7%. Lugar: hogar 36,2% (IC95%: 31,5-41%. Lesión más frecuente: contusiones 39,6% (IC95%:34,7-44,4%.Localización más frecuente: extremidad superior 37,5% (IC95%: 32,7-42,3%; Agente mayoritariamente implicado: herramientas y máquinas: 15,9% (IC95%:12,3-19,6%. El 92,2% (IC95%: 89,3-94,7% fueron casuales. Tipo de visita: el 83,3% (IC95%: 79,6-87% fueron atendidos con carácter urgente; el 79,5% (IC95%:75,4-83,5% recibió tratamiento con cura y/o fármacos. El 9,8% (IC95%:6,8-12,7% requirió derivación hospitalaria, Un 13,3% (IC95%: 0-16,7% requirió pruebas complementarias. Conclusiones: El mayor porcentaje de accidentalidad se da en población joven, por lo que se evidencia la necesidad de incorporar intervenciones de

Evaluation of gamma radiation induced genetic damage in the fish Cyprinus carpio using comet assay

International Nuclear Information System (INIS)

Praveen Kumar, M.K.; Shyama, S.K.; Bhagat, S.S.; Chaubey, R.C.

2013-01-01

Radionuclides released from various sources including the industries, as well as, accidental release during a nuclear disaster can contaminate inland water bodies. Suitable bio-monitoring methods/biomarkers are the need of the day to assess the impact of high/low levels of radiation exposure in aquatic environment. Fishes are very important as a group of ecologically and commercially important non-human biota and are often used as a bioindicators of aquatic pollution. Present work was carried out to assess the genotoxic effect of gamma radiation on fresh water fish Cyprinus carpio (common carp) in vivo using comet assay. Fishes were irradiated with 2, 4, 6, 8 and 10 Gy of gamma rays using a teletherapy machine and comet assay was performed on nucleated erythrocytes after 24, 48 and 72 h of irradiation . A significant increase in % tail DNA was observed at all the doses of gamma radiation as compared to controls indicating radiation induced DNA damage in a dose-dependent manner. Maximum % tail DNA was observed at 24 h which gradually declined till 72 h, in a time-dependent manner. This decrease in damage may indicate repair of the damaged DNA and or loss of heavily damaged cells, over a period of time. The study reveals that the comet assay may be used as a sensitive and rapid method to detect genotoxicity of gamma radiation and other environmental pollutants in sentinel species. (author)

Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine

International Nuclear Information System (INIS)

Yamauchi, Hiroshi; Aminaka, Yoshito; Yoshida, Katsumi; Sun Guifan; Pi Jingbo; Waalkes, Michael P.

2004-01-01

The relationship between arsenic exposure and DNA damage in patients with acute or chronic arsenic poisoning was analyzed. Urinary 8-hydroxydeoxyguanine (8-OHdG) concentrations were measured as an indication of oxidative DNA damage. A remarkable increase in 8-OHdG in the urine was observed in 60% of 52 patients with acute arsenic poisoning from the accidental oral intake of the arsenic trioxide. This was two- to threefold higher than levels in normal healthy subjects (n = 248). There was a clear relationship between arsenic concentrations in urine after acute poisoning and elevated levels of 8-OHdG. Levels of urinary 8-OHdG returned to normal within 180 days after the acute arsenic poisoning event. In patients chronically poisoned by the consumption of well water with elevated levels of arsenate [As(V)], elevated 8-OHdG concentrations in urine were also observed. A significant correlation between the 8-OHdG levels and arsenic levels in the urine was observed in 82 patients with chronic poisoning. Thus, evidence of oxidative DNA damage occurred in acute arsenic poisoning by arsenite [As(III)] and in chronic arsenic poisoning by As(V). In chronic poisoning patients provided low-arsenic drinking water, evidence of DNA damage subsided between 9 months and 1 year after the high levels of arsenic intake were reduced. The initial level of arsenic exposure appeared to dictate the length of this recovery period. These data indicate that some aspects of chronic and acute arsenic poisoning may be reversible with the cessation of exposure. This knowledge may contribute to our understanding of the risk elevation from arsenic carcinogenesis and perhaps be used in a prospective fashion to assess individual risk

Research progress in study of accidental hypothermia

Directory of Open Access Journals (Sweden)

Rui YUAN

2016-04-01

Full Text Available Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypothermia. A series of rewarming measures, such as infusion of warm fluids, inspiration of warm air, abdominal infusion of warm fluid, instruction of warm fluid into pleural cavity, intravenous infusion of warm fluid, rewarming through ECMO, etc. have been used recently. Advance in research on the classification of hypothermia, its impact to the body and the treatment methods are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2016.04.15

Fatal accidental inhalation of brake cleaner aerosols.

Science.gov (United States)

Veit, F; Martz, W; Birngruber, C G; Dettmeyer, R B

2018-04-23

Brake cleaner liquid is commonly used for cleaning of engines and motor parts. The commercially available products usually contain mainly volatile organic compounds. As a consequence brake cleaner evaporates fast and almost completely from the cleaned surface. This case report presents a fatal accidental inhalation of brake cleaner liquid aerosols due to the attempted cleaning of a boat engine. A 16year old boy was found lifeless in the engine compartment of a boat engine. In close proximity to the body, the police found cleanings wipes soaked with brake cleaner as well as a pump spray bottle filled with brake cleaner. Essentially the autopsy revealed a cerebral oedema with encephalomalacia, no coagulated blood as well as increased blood and tissue fluid content of the lung. Toxicological analysis revealed brake cleaner fluid in the lung, gastric content and heart blood. Copyright © 2018 Elsevier B.V. All rights reserved.

Consequences of a double-ended severance of a steam generator tube and accidental development scenario

International Nuclear Information System (INIS)

Smirnov, M.V.; Titov, V.F.; Poplavskii, V.M.; Baklushin, R.P.

1988-01-01

The results of theoretical analysis for accidental sequences in a modular steam generator are presented. The most probable water leak development in sodium in case of steam generator emergency stop faults is examined. In all schemes the reactor safety is preserved [fr

Overview study of LNG release prevention and control systems

Energy Technology Data Exchange (ETDEWEB)

Pelto, P.J.; Baker, E.G.; Holter, G.M.; Powers, T.B.

1982-03-01

The liquefied natural gas (LNG) industry employs a variety of release prevention and control techniques to reduce the likelihood and the consequences of accidental LNG releases. A study of the effectiveness of these release prevention and control systems is being performed. Reference descriptions for the basic types of LNG facilities were developed. Then an overview study was performed to identify areas that merit subsequent and more detailed analyses. The specific objectives were to characterize the LNG facilities of interest and their release prevention and control systems, identify possible weak links and research needs, and provide an analytical framework for subsequent detailed analyses. The LNG facilities analyzed include a reference export terminal, marine vessel, import terminal, peakshaving facility, truck tanker, and satellite facility. A reference description for these facilities, a preliminary hazards analysis (PHA), and a list of representative release scenarios are included. The reference facility descriptions outline basic process flows, plant layouts, and safety features. The PHA identifies the important release prevention operations. Representative release scenarios provide a format for discussing potential initiating events, effects of the release prevention and control systems, information needs, and potential design changes. These scenarios range from relatively frequent but low consequence releases to unlikely but large releases and are the principal basis for the next stage of analysis.

Radiation damage of structural materials

International Nuclear Information System (INIS)

Koutsky, J.; Kocik, J.

1994-01-01

Maintaining the integrity of nuclear power plants (NPP) is critical in the prevention or control of severe accidents. This monograph deals with both basic groups of structural materials used in the design of light-water nuclear reactors, making the primary safety barriers of NPPs. Emphasis is placed on materials used in VVER-type nuclear reactors: Cr-Mo-V and Cr-Ni-Mo-V steel for reactor pressure vessels (RPV) and Zr-Nb alloys for fuel element cladding. The book is divided into seven main chapters, with the exception of the opening one and the chapter providing phenomenological background for the subject of radiation damage. Chapters 3-6 are devoted to RPV steels and chapters 7-9 to zirconium alloys, analyzing their radiation damage structure, changes of mechanical properties due to neutron irradiation as well as factors influencing the degree of their performance degradation. The recovery of damaged materials is also discussed. Considerable attention is paid to a comparison of VVER-type and western-type light-water materials

Analysis Of Damage Arising From Exploitation Of The Aircraft

Directory of Open Access Journals (Sweden)

Woźny Piotr

2014-12-01

Full Text Available During exploitation, due to a variety of reasons, aircrafts are damaged or suffer from different failures. In the process of operation, using appropriate methods of diagnosis, failure, damage, and relative deregulation of individual elements or units can be detected. For this purpose, one can apply a number of indirect diagnostic methods with the use of recorded diagnostic signals or a direct diagnosis with the use of non-destructive methods. The proper identification of the technical condition allows to determine the causes of irregularities and take actions aimed at preventing their occurrence. The article presents the types of exploitation damage of a multi-purpose aircraft. In addition, the criteria for the division of damage and research methods of the causes of damage are presented. Furthermore, an analysis of the scope of activities to be performed during the research of causes of damage to the aircraft is made.

Cellular Responses to Cisplatin-Induced DNA Damage

Directory of Open Access Journals (Sweden)

Alakananda Basu

2010-01-01

Full Text Available Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis. How cells respond to cisplatin-induced DNA damage plays a critical role in deciding cisplatin sensitivity. Cisplatin-induced DNA damage activates various signaling pathways to prevent or promote cell death. This paper summarizes our current understandings regarding the mechanisms by which cisplatin induces cell death and the bases of cisplatin resistance. We have discussed various steps, including the entry of cisplatin inside cells, DNA repair, drug detoxification, DNA damage response, and regulation of cisplatin-induced apoptosis by protein kinases. An understanding of how various signaling pathways regulate cisplatin-induced cell death should aid in the development of more effective therapeutic strategies for the treatment of cancer.

Bilding (Kay) Ki Damaje PSA (:60) (Damaged Buildings)

Centers for Disease Control (CDC) Podcasts

2010-02-18

An important public health announcement about your safety when entering damaged buildings. Language: Haitian Creole.  Created: 2/18/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 2/18/2010.

Study of Engraftment of human cord blood cells to rescue the sublethal radiation damage mice

International Nuclear Information System (INIS)

Cao Xiangshan; Zou Zhenghui; Yu Fei; Zhang Zhilin; Lin Baojue

1997-01-01

To investigate alternative source of hematopoiesis stem cells to rescue the sublethal radiation damage (SRD) casualties. Human-umbilical cord blood hematopoietic cells were transplanted into SRD mice, the survival rate and the hematopoiesis reconstitution of bone marrow were assessed. The survival rate, in the mice transplanted and the untransplanted, were 90% and 10% respectively. Bone marrow and spleen of survival mice showed human leukocytic antigen CD45 + cells. Presence of multilineage engraftment, including myeloid and erythroid lineages, were found indicating that immature human cells home to the mouse bone marrow. conclusion: engraftment of umbilical cord blood cells is very useful to reconstitute hematopoiesis of SRD casualties. As cord blood has many advantages over bone marrow and peripheral blood, it is important in rescuing radiation accidental casualties

Pathological Findings in Accidental Electrocution in a Horse (Case Report

Directory of Open Access Journals (Sweden)

Adrian Florin Gal

2016-11-01

Full Text Available Recently, the veterinarians are dealing with a number of cases that require forensic expertise. Such a circumstance could be the accidental electrocution in animals, one of the causes of unnatural death. There is a scarcity with reference to the pathological findings in veterinary forensic medicine. In this paper, we present the main lesions that occurred in a horse with accidental electrocution that was presented for complete necropsy survey. A horse corpse was sent to the Pathology Department (Faculty of Veterinary Medicine, Cluj-Napoca, Romania for a full medical survey. Preliminary results and external examination: the body was in rigor mortis; from the nasal cavities drained out reddish foam and in the mouth was observed the presence of ingested feed (straw that was not chewed, suggesting a quick death. The findings detected after internal examination of the carcass were poor blood coagulability, haemorrhagic diathesis throughout the body, with haemorrhages of various sizes in different body regions (e.g., muscles of the withers, in the gluteal muscle, the mucosa of epiglottis, larynx, trachea, in the interstitium of the lung, and ecchymosis in the left kidney. Some other lesions detected were infarcts and haemorrhages in the fundic region of the stomach’s mucosa. In electrocution, haemorrhages are most often located in the respiratory tract, aspect observed in our case too. However, the diagnosis of electrocution has to corroborate the necropsy findings (which are not specific, with some other data such as the fulminant death and inspection of power source.

Return on experience of the post-accidental management of the Chernobyl accident within the Belarusian context - PAREX. Synthesis report delivered to the ASN on the 19 March 2007

International Nuclear Information System (INIS)

Heriard Dubreuil, Gilles; Lochard, Jacques; Ollagnon, Henry; Baude, Stephane; Bataille, Celine

2007-01-01

This approach to a return on experience of the post-accidental management of the Chernobyl accident identified four main steps: the passage from an accidental phase to a post-accidental phase from 1986 to 1991 (implementation of countermeasures, design of a radiological protection), the setting of an institutional and legal framework for the post-accidental management from 1991 to 1993 (compensations, definition of standards for food production and consumption, psychological support of populations), the search for alternative strategies from 1993 to 2001, and a sustainable rehabilitation of living conditions in contaminated territories between 2001 and 2006. Based on the return on experience on this various issues, the authors draw a set of lessons and give recommendations. They notably address the characteristics of a situation of durable radiological contamination, the role of standards in the response to a post-accidental situation, the role of expertise and knowledge building, the role and action of public authorities, the progressive building up of a local response to the crisis, the preparedness to a situation of durable contamination

Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage

OpenAIRE

Zhang, Pan; Herbig, Utz; Coffman, Frederick; Lambert, Muriel W.

2013-01-01

Telomere integrity is critical for telomere function and genomic stability. We previously demonstrated that non-erythroid ?-spectrin (?IISp) is present in mammalian cell nuclei where it is important in repair of DNA interstrand cross-links (ICLs) and chromosome stability. We now demonstrate that ?IISp is also important for telomere maintenance after ICL damage. It localizes to telomeres in S phase after ICL damage where it has enhanced association with TRF1 and TRF2 and is required for recrui...

Reporting a sudden death due to accidental gasoline inhalation.

Science.gov (United States)

Martínez, María Antonia; Ballesteros, Salomé; Alcaraz, Rafael

2012-02-10

The investigation of uncertain fatalities requires accurate determination of the cause of death, with assessment of all factors that may have contributed to it. Gasoline is a complex and highly variable mixture of aliphatic and aromatic hydrocarbons that can lead to cardiac arrhythmias due to sensitization of the myocardium to catecholamines or acts as a simple asphyxiant if the vapors displace sufficient oxygen from the breathing atmosphere. This work describes a sudden occupational fatality involving gasoline. The importance of this petroleum distillate detection and its quantitative toxicological significance is discussed using a validated analytical method. A 51 year-old Caucasian healthy man without significant medical history was supervising the repairs of the telephone lines in a manhole near to a gas station. He died suddenly after inhaling gasoline vapors from an accidental leak. Extensive blistering and peeling of skin were observed on the skin of the face, neck, anterior chest, upper and lower extremities, and back. The internal examination showed a strong odor of gasoline, specially detected in the respiratory tract. The toxicological screening and quantitation of gasoline was performed by means of gas chromatography with flame ionization detector and confirmation was performed using gas chromatography-mass spectrometry. Disposition of gasoline in different tissues was as follows: heart blood, 35.7 mg/L; urine, not detected; vitreous humor, 1.9 mg/L; liver, 194.7 mg/kg; lung, 147.6 mg/kg; and gastric content, 116,6 mg/L (2.7 mg total). Based upon the toxicological data along with the autopsy findings, the cause of death was determined to be gasoline poisoning and the manner of death was accidental. We would like to alert on the importance of testing for gasoline, and in general for volatile hydrocarbons, in work-related sudden deaths involving inhalation of hydrocarbon vapors and/or exhaust fumes. Copyright © 2011 Elsevier Ireland Ltd. All rights

Dose assessment of an accidental exposure at IPNS

International Nuclear Information System (INIS)

Torres, M.M.C.

1996-01-01

Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose rates ranged from 550 mrem/min to 2,850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem

Muertes por accidente de motocicleta y su asociación con variables relacionadas a la reproducción social en un estado del noreste brasileño

Directory of Open Access Journals (Sweden)

Paul Hindenburg Nobre de Vasconcelos Silva

2015-01-01

Full Text Available El objetivo de este artículo es identificar el comportamiento de las muertes por accidentes de motocicleta y las variables relacionadas con la teoría de la reproducción social de Samaja, para el período 2000-2005 en el estado de Pernambuco, Brasil. Se realizó un estudio ecológico con abordaje caso-control. La unidad de análisis fue el municipio. Los casos fueron definidos considerando el 20% de los municipios con los mayores coeficientes bayesianos empíricos locales de mortalidad por accidentes de motocicleta y los controles, como el 40% de los municipios con menores coeficientes de mortalidad por accidentes de motocicleta. Los municipios con mayor probabilidad de altos coeficientes de mortalidad por accidentes de motocicleta mostraron factores de crecimiento poblacional altos, así como de crecimiento de la flota de vehículos, bajas densidades demográficas, bajo PBI per cápita, y más de 20 motocicletas por mil habitantes. Se concluye que las variables relacionadas a las macropolíticas mostraron una mayor fuerza para explicar las probabilidades de defunciones por accidentes de motocicleta.

Preventing thefts and damage to property

CERN Multimedia

2013-01-01

The best means of preventing crime is to make it difficult to commit. As the summer holidays begin, in everybody's interest we advise the following precautions.   1. Money, valuables and keys Never leave money or objects of value unattended in offices or changing rooms, even if they are locked. Keys and spares must always be taken away or kept in a safe place. Supposedly "safe" hiding places such as drawers, even locked ones, metal boxes and flower pots, are well known to burglars and should be avoided. Change lock codes regularly. 2. Doors and windows Offices, workshops and meeting rooms, etc. should be locked when vacated. Care should also be taken that windows are properly shut, especially if they are easily accessible from the outside. 3. Vandalism If you witness an act of vandalism of public or private property, please report all the facts and your observations immediately to the CERN Fire Brigade (74444). 4. Reporting incidents Every misdemeanour solved increase...

Preventing thefts and damage to property

CERN Document Server

HR Department

2007-01-01

Discouraging thieves is the best way of protecting your property. On the eve of CERN's annual end-of-year closure, in your own interest, that of your colleagues and that of the Organization, we would strongly advise you to take the following precautions: MONEY, VALUABLES & KEYS: Do not leave money or valuables in your office or your lockers. Keys and spare keys must be taken away or kept in a safe place (please avoid supposedly 'safe hiding places' such as drawers, even if they are locked, metal boxes and flowers pots, all of which are well-known to burglars). Change lock codes regularly. Be careful if you have to leave your keys with a third party and make sure that they do not pass them on to anyone else. DOORS & WINDOWS: Lock office, workshop and meeting-room doors, etc. when you leave. Also make sure windows are properly shut, especially if they are easily accessible from outside. REPORTING INCIDENTS: Each theft solved could prevent another from be...

Simulation of pulsed accidental energy release in a reactor core

International Nuclear Information System (INIS)

Ryshanskii, V.A.; Ivanov, A.G.; Uskov, A.A.

1995-01-01

At the present time the strength of the load-bearing members of VVER and fast reactors during a hypothetical accident is ordinarily investigated in model experiments [1]. A power burst during an accident is simulated by a nonnuclear exothermal reaction in water, which simulates the coolant and fills the model. The problem is to make the correct choice of the simulator of the accidental energy burst as an effective (i.e., sufficiently high working capacity) source of dangerous loads, corresponding to the conditions of an accident. What factors and parameters determine the energy release? The answers to these questions are contradictory

INHIBITION OF FRIED MEAT-INDUCED DNA DAMAGE: A DIETARY INTERVENTION STUDY IN HUMANS

Science.gov (United States)

Dietary exposures have been implicated as risk factors in colorectal cancer. Such agents may act by causing DNA damage or may be protective against DNA damage. The effects of dietary exposures in causing or preventing damage have not been assessed directly in colon tissues. In th...

Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

Science.gov (United States)

Kranjcec, Darko; Bergovec, Mijo; Rougier, Jean-Sébastien; Raguz, Miroslav; Pavlovic, Sonja; Jespersen, Thomas; Castella, Vincent; Keller, Dagmar I; Abriel, Hugues

2007-10-01

Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors. His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology experiments confirmed the loss-of-function of the mutant allele. The patient was implanted with a cardioverter/defibrillator.

Bilirubin and its oxidation products damage brain white matter

Science.gov (United States)

Lakovic, Katarina; Ai, Jinglu; D'Abbondanza, Josephine; Tariq, Asma; Sabri, Mohammed; Alarfaj, Abdullah K; Vasdev, Punarjot; Macdonald, Robert Loch

2014-01-01

Brain injury after intracerebral hemorrhage (ICH) occurs in cortex and white matter and may be mediated by blood breakdown products, including hemoglobin and heme. Effects of blood breakdown products, bilirubin and bilirubin oxidation products, have not been widely investigated in adult brain. Here, we first determined the effect of bilirubin and its oxidation products on the structure and function of white matter in vitro using brain slices. Subsequently, we determined whether these compounds have an effect on the structure and function of white matter in vivo. In all, 0.5 mmol/L bilirubin treatment significantly damaged both the function and the structure of myelinated axons but not the unmyelinated axons in brain slices. Toxicity of bilirubin in vitro was prevented by dimethyl sulfoxide. Bilirubin oxidation products (BOXes) may be responsible for the toxicity of bilirubin. In in vivo experiments, unmyelinated axons were found more susceptible to damage from bilirubin injection. These results suggest that unmyelinated axons may have a major role in white-matter damage in vivo. Since bilirubin and BOXes appear in a delayed manner after ICH, preventing their toxic effects may be worth investigating therapeutically. Dimethyl sulfoxide or its structurally related derivatives may have a potential therapeutic value at antagonizing axonal damage after hemorrhagic stroke. PMID:25160671

Spontaneous hematologic recovery from bone marrow aplasia after accidental tenfold overdosage with radiophosphorus

International Nuclear Information System (INIS)

Gmuer, J.; Bischof, B.; Coninx, S.

1983-01-01

Two patients with polycythemia vera received intravenously an accidental tenfold overdosage of radiophosphorus therapy (60 and 50 mCi 32P, respectively). In both patients, the occurrence of hemorrhagic complications 3 wk after the 32P medication led to detection of the error and referral to our hospital. Upon admission they showed an agranulocytosis, severe thrombocytopenia, and bone marrow aplasia. In both cases, spontaneous recovery of the hematopoiesis was observed from day 40 posttreatment onward. In one patient, a slow but ultimately complete normalization of blood counts and marrow morphology took place, whereas in the other, a mild thrombocytopenia persists. Nearly 5 yr after the accidental overdosage, both patients are clinically well. Symptoms of polycythemia vera have not reappeared up to now. Attempts were made to evaluate the radiation dose absorbed by the bone marrow. In the first patient, the daily 32P excretion was determined from day 22 to day 60, whereas in the other patient a whole body count was performed on day 78 after administration. From these results, an approximate cumulative bone marrow dose of 10 Sv (1000 rem) could be calculated

The role of the follow-up chest radiograph in suspected non-accidental injury

Energy Technology Data Exchange (ETDEWEB)

Anilkumar, Adikesavalu; Fender, Laura J; Broderick, Nigel J; Somers, John M; Halliday, Katharine E [Nottingham University Hospital NHS Trust, Department of Radiology, Queen' s Medical Centre, Nottingham (United Kingdom)

2006-03-15

Rib fractures in children under the age of 2 years have a strong correlation with non-accidental injury (NAI). Follow-up radiographs can improve detection. To evaluate the value of the follow-up chest radiograph in suspected non-accidental injury. The study included all children less than 2 years of age who were investigated for suspected NAI in our institution between January 1998 and October 2003. Prior to January 2000, only selected patients were asked to attend for a follow-up chest radiograph. From January 2000 onwards all children were asked to reattend. Of 200 children included in the study, 59 (29.5%) reattended for a follow-up chest radiograph. The follow-up film provided useful additional information in 7 (12%) of the 59 children. In two children rib fractures were noted only on the follow-up chest radiograph. In a further two patients additional rib fractures were noted. Additional dating information was obtained for two patients. For one child both additional fractures and dating information were noted. The follow-up chest radiograph provides useful information in children with suspected NAI and it is recommended that it should be included routinely in the imaging investigations of these children. (orig.)

The role of the follow-up chest radiograph in suspected non-accidental injury

International Nuclear Information System (INIS)

Anilkumar, Adikesavalu; Fender, Laura J.; Broderick, Nigel J.; Somers, John M.; Halliday, Katharine E.

2006-01-01

Rib fractures in children under the age of 2 years have a strong correlation with non-accidental injury (NAI). Follow-up radiographs can improve detection. To evaluate the value of the follow-up chest radiograph in suspected non-accidental injury. The study included all children less than 2 years of age who were investigated for suspected NAI in our institution between January 1998 and October 2003. Prior to January 2000, only selected patients were asked to attend for a follow-up chest radiograph. From January 2000 onwards all children were asked to reattend. Of 200 children included in the study, 59 (29.5%) reattended for a follow-up chest radiograph. The follow-up film provided useful additional information in 7 (12%) of the 59 children. In two children rib fractures were noted only on the follow-up chest radiograph. In a further two patients additional rib fractures were noted. Additional dating information was obtained for two patients. For one child both additional fractures and dating information were noted. The follow-up chest radiograph provides useful information in children with suspected NAI and it is recommended that it should be included routinely in the imaging investigations of these children. (orig.)

Accidental releases of radionuclides: a preliminary study of the consequences of land contamination

International Nuclear Information System (INIS)

Simmonds, J.R.; Haywood, S.M.; Linsley, G.S.

1982-10-01

The long term consequences of land contamination from accidental releases of activity from thermal reactors are examined. The radiological consequences are assessed using an analysis of the exposure of individuals and the population to ground deposits of the radionuclides released. The contribution of the different nuclides in the release by their various exposure routes to the irradiation of man are calculated as a function of time after release and the most radiologically important are identified. A preliminary assessment is made of off-site economic and social consequences of accidental releases by estimating the areas of land which would be affected by the introduction of countermeasures to control individual radiation exposure due to external irradiation from ground deposits (relocation of populations), and the intake of radionuclides contained in locally produced foodstuffs (restrictions on food production). The areas where administrative controls would be necessary decline in size with time after the release; estimates are made of this time-dependent behaviour using dynamic environmental transfer models. Finally, the collective doses saved by the introduction of countermeasures are estimated using population and agricultural distribution data for a rural location in the United Kingdom. (author)

Metabolite damage and repair in metabolic engineering design.

Science.gov (United States)

Sun, Jiayi; Jeffryes, James G; Henry, Christopher S; Bruner, Steven D; Hanson, Andrew D

2017-11-01

The necessarily sharp focus of metabolic engineering and metabolic synthetic biology on pathways and their fluxes has tended to divert attention from the damaging enzymatic and chemical side-reactions that pathway metabolites can undergo. Although historically overlooked and underappreciated, such metabolite damage reactions are now known to occur throughout metabolism and to generate (formerly enigmatic) peaks detected in metabolomics datasets. It is also now known that metabolite damage is often countered by dedicated repair enzymes that undo or prevent it. Metabolite damage and repair are highly relevant to engineered pathway design: metabolite damage reactions can reduce flux rates and product yields, and repair enzymes can provide robust, host-independent solutions. Herein, after introducing the core principles of metabolite damage and repair, we use case histories to document how damage and repair processes affect efficient operation of engineered pathways - particularly those that are heterologous, non-natural, or cell-free. We then review how metabolite damage reactions can be predicted, how repair reactions can be prospected, and how metabolite damage and repair can be built into genome-scale metabolic models. Lastly, we propose a versatile 'plug and play' set of well-characterized metabolite repair enzymes to solve metabolite damage problems known or likely to occur in metabolic engineering and synthetic biology projects. Copyright © 2017 International Metabolic Engineering Society. All rights reserved.

Damages on pumps and systems the handbook for the operation of centrifugal pumps

CERN Document Server

Merkle, Thomas

2014-01-01

Damage on Pumps and Systems. The Handbook for the Operation of Centrifugal Pumps offers a combination of the theoretical basics and practical experience for the operation of circulation pumps in the engineering industry. Centrifugal pumps and systems are extremely vulnerable to damage from a variety of causes, but the resulting breakdown can be prevented by ensuring that these pumps and systems are operated properly. This book provides a total overview of operating centrifugal pumps, including condition monitoring, preventive maintenance, life cycle costs, energy savings and economic aspects. Extra emphasis is given to the potential damage to these pumps and systems, and what can be done to prevent breakdown. Addresses specific issues about pumping of metal chips, sand, abrasive dust and other solids in fluidsEmphasis on economic and efficiency aspects of predictive maintenance and condition monitoring Uses life cycle costs (LCC) to evaluate and calculate the costs of pumping systems

[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)

NARCIS (Netherlands)

Hameleers-Snijders, P.; Hogeveen, M.; Smeitink, J.A.M.; Kramers, C.; Draaisma, J.M.T.

2007-01-01

Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider

Effects of microscale damage evolution on piezoresistive sensing in nanocomposite bonded explosives under dynamic loading via electromechanical peridynamics

Science.gov (United States)

Prakash, Naveen; Seidel, Gary D.

2018-01-01

Polymer bonded explosives can sustain microstructural damage due to accidental impact, which may reduce their operational reliability or even cause unwanted ignition leading to detonation of the explosive. Therefore a nanocomposite piezoresistivity based sensing solution is discussed here that employs a carbon nanotube based nanocomposite binder in the explosive material by which in situ real-time sensing can be obtained. A coupled electromechanical peridynamics code is used to numerically obtain the piezoresistive response of such a material under dynamic conditions, which allows one to capture damage initiation and propagation mechanisms due to stress waves. The relative change in resistance at three locations along the length of the microstructure is monitored, and found to correlate well with deformation and damage mechanisms within the material. This response can depend on many factors, such as carbon nanotube content, electrical conductivity of the grain, impact velocity and fracture properties, which are explored through numerical simulations. For example, it is found that the piezoresistive response is highly dependent on preferential pathways of electrical current , i.e. the phase through which the current flows, which is in turn affected by the conductivity of the grain and the specific pattern of damage. It is found that the results qualitatively agree with experimental data on the dynamic piezoresistive response of nanocomposites and look promising as a sensing mechanism for explosive materials.

Outcome of Accidental Exposure Prone to Blood Borne Viral Infections in an Educational Hospital

Directory of Open Access Journals (Sweden)

Shahnaz Sali

2016-04-01

Full Text Available Background: The risk for transmission of blood-borne viruses (BBVs such as Human immunodeficiency virus (HIV, hepatitis B virus (HBV and hepatitis C virus (HCV due to occupational exposure is a major concern in the health care setting.Materials and Methods: This study among 337 health care workers (HCWs accidentally exposed to BBVs was carried out from January 2009 to March 2015. The data were reviewed in labbafinejhad hospital, Tehran, Iran.Results: 4 HCWs had exposure to HBS Ag positive, which HBS antibody titer of them was higher than 10 mlu/ml, 6 HCWs were exposed to HCV seropositive patients underwent laboratory investigations for  HCV-antibody on 4,12, 24 weeks that results were negative. 3 cases had exposure to HIV seropositive patients which received standard antiretroviral post exposure prophylaxis.Conclusion: Timely performance for PEP (Post Exposure Prophylaxis reducing BBVs transmission among HCWs.prophylaxis. Conclusions: Timely performance for  PEP(Post Exposure Prophylaxis reducing BBVs transmission among HCWs.Key words: Outcome; Accidental Exposure; Blood Borne Viral Infections

Marine oil spill risk mapping for accidental pollution and its application in a coastal city.

Science.gov (United States)

Lan, Dongdong; Liang, Bin; Bao, Chenguang; Ma, Minghui; Xu, Yan; Yu, Chunyan

2015-07-15

Accidental marine oil spill pollution can result in severe environmental, ecological, economic and other consequences. This paper discussed the model of Marine Oil Spill Risk Mapping (MOSRM), which was constructed as follows: (1) proposing a marine oil spill risk system based on the typical marine oil spill pollution accidents and prevailing risk theories; (2) identifying suitable indexes that are supported by quantitative sub-indexes; (3) constructing the risk measuring models according to the actual interactions between the factors in the risk system; and (4) assessing marine oil spill risk on coastal city scale with GIS to map the overall risk. The case study of accidental marine oil spill pollution in the coastal area of Dalian, China was used to demonstrate the effectiveness of the model. The coastal areas of Dalian were divided into three zones with risk degrees of high, medium, and low. And detailed countermeasures were proposed for specific risk zones. Copyright © 2015 Elsevier Ltd. All rights reserved.

Intervenção comunitária para prevenção de acidentes de trânsito entre trabalhadores ciclistas Intervención comunitaria para la prevención de accidentes de tránsito entre trabajadores ciclistas A community intervention to prevent traffic accidents among bicycle commuters

Directory of Open Access Journals (Sweden)

Giancarlo Bacchieri

2010-10-01

intervención educacional de prevención de accidentes de tránsito con trabajadores que utilizan la bicicleta como modo de transporte. MÉTODOS: Estudio de intervención, longitudinal, con implementación escalonada, realizado en cinco urbanizaciones con características geográficas distintas en la ciudad de Pelotas, Sur de Brasil, de enero de 2006 a mayo de 2007. Fueron sorteados 42 sectores censados de dichas urbanizaciones. Todos los domicilios fueron visitados en búsqueda de trabajadores del sexo masculino que utilizasen la bicicleta como modo de transporte, resultando en una muestra de 1.133 individuos. Fueron analizados como resultados "accidentes de tránsito" y "casi-accidentes". Mensualmente, vía telefónica, los ciclistas eran interrogados con respecto a la ocurrencia de accidentes de tránsito y de "casi-accidentes". Quincenalmente, a partir del segundo mes de acompañamiento, un grupo de aproximadamente 60 ciclistas era convidado a participar de la intervención, que incluía un componente educativo (seminario y presentación de video educativo, distribución de un kit de seguridad (chaleco nocturno con reflexivo, cartilla educativa y cintas reflexivas y revisión de los frenos de la bicicleta (mantenimiento realizado al ser necesario. Regresión de Poisson, con ajuste para el efecto del tiempo, fue utilizada para medir el efecto de la intervención. RESULTADOS: Aproximadamente 45% de los ciclistas no comparecieron a la intervención. Durante el período de estudio, 9% de los individuos informaron un accidente de tránsito y 88% un casi-accidente. En total, ocurrieron 106 accidentes y 1.091 casi-accidentes. No fue observado efecto de la intervención en ambos resultados. CONCLUSIONES: La intervención propuesta no fue capaz de reducir accidentes entre trabajadores ciclistas. falta de interés en seguridad por parte de los ciclistas y factores externos, tales como infra-estructura de las vías y comportamiento de los choferes, pueden haber colaborado para ese

The DNA damage response in mammalian oocytes

Directory of Open Access Journals (Sweden)

John eCarroll

2013-06-01

Full Text Available DNA damage is one of the most common insults that challenge all cells. To cope, an elaborate molecular and cellular response has evolved to sense, respond to and correct the damage. This allows the maintenance of DNA fidelity essential for normal cell viability and the prevention of genomic instability that can lead to tumour formation. In the context of oocytes, the impact of DNA damage is not one of tumour formation but of the maintenance of fertility. Mammalian oocytes are particularly vulnerable to DNA damage because physiologically they may lie dormant in the ovary for many years (>40 in humans until they receive the stimulus to grow and acquire the competence to become fertilized. The implication of this is that in some organisms, such as humans, oocytes face the danger of cumulative genetic damage for decades. Thus, the ability to detect and repair DNA damage is essential to maintain the supply of oocytes necessary for reproduction. Therefore, failure to confront DNA damage in oocytes could cause serious anomalies in the embryo that may be propagated in the form of mutations to the next generation allowing the appearance of hereditary disease. Despite the potential impact of DNA damage on reproductive capacity and genetic fidelity of embryos, the mechanisms available to the oocyte for monitoring and repairing such insults have remained largely unexplored until recently. Here, we review the different aspects of the response to DNA damage in mammalian oocytes. Specifically, we address the oocyte DNA damage response from embryonic life to adulthood and throughout oocyte development.

Implantação de um kit para comunicação de acidente do trabalho (KIT-CAT como facilitador das ações que envolvem os acidentes com perfurocortantes Implantación de un kit para comunicación de accidente de trabajo (KIT CAT como facilitador de las acciones que involucran los accidentes con perfurocortantes Implementation of a kit for the communication of occupational accidents (KIT CAT as a facilitator for the actions involving puncture cutting accidents

Directory of Open Access Journals (Sweden)

Cristina Maria Fernandes Porto

1999-12-01

Full Text Available Este trabalho destaca a criação e aplicação na prática profissional, de um Kit para Comunicação de Acidente de Trabalho com perfurocortantes para a Secretaria Municipal da Saúde de Ribeirão Preto, como um instrumento indispensável à prestação de serviços de assistência à saúde dos funcionários das Unidades de Saúde do município. Evidencia a notificação e início da prevenção das doenças ocupacionais, sendo assim, um instrumento extremamente útil quando da ocorrência do acidente. A criação deste Kit possibilitou a retomada de medidas de prevenção dos acidentes ocupacionais, culminando com a mobilização de servidores e chefias na intensificação das ações preventivas.Este trabajo destaca la creación y aplicación en la practica profesional de un KIT para Comunicación de Accidente de Trabajo con perfurocortantes para la Secretaría Municipal de la Salud de Ribeirão Preto, como instrumento indispensable a la prestación de servicios de asistencia a la salud de los funcionarios de las Unidades de Salud del Municipio. Evidencia la notificación y el inicio de la prevención de enfermedades ocupacionales, siendo así, un instrumento extremamente útil cuando de la ocurrencia del accidente. La creación de este KIT, ha posibilitado la retomada de medidas de prevención de los accidentes ocupacionales, culminando con la movilización de servidores y jefes en la intensificación de las acciones preventivas.This paper emphasizes the creation and application of a KIT for the communication of occupational accidents with puncture-cutting objects to the Municipal Health Bureau from the city of Ribeirão Preto. It is an essential instrument for the health care services directed to all the employees of the Health Units. It also evidences the notification and the beginning of the prevention of occupational diseases, being a highly useful instrument whenever any accident occurs. The creation of this KIT enabled the use of

Natural plant polyphenols for alleviating oxidative damage in man ...

African Journals Online (AJOL)

prevent the body from oxidative damage over human life span. This review .... Antioxidant supplementation/treatment has been adopted for .... deacetylase family regulates gene silencing and .... Drug News Perspect 2007; 20: 579-. 585. 12.

Radiation-induced liver damage

International Nuclear Information System (INIS)

Marcial, V.A.; Santiago-Delpin, E.A.; Lanaro, A.E.; Castro-Vita, H.; Arroyo, G.; Moscol, J.A.; Gomez, C.; Velazquez, J.; Prado, K.

1977-01-01

Due to the recent increase in the use of radiation therapy in the treatment of cancer with or without chemotherapy, the risk of liver radiation damage has become a significant concern for the radiotherapist when the treated tumour is located in the upper abdomen or lower thorax. Clinically evident radiation liver damage may result in significant mortality, but at times patients recover without sequelae. The dose of 3000 rads in 3 weeks to the entire liver with 5 fractions per week of 200 rads each, seems to be tolerated well clinically by adult humans. Lower doses may lead to damage when used in children, when chemotherapy is added, as in recent hepatectomy cases, and in the presence of pre-existent liver damage. Reduced fractionation may lead to increased damage. Increased fractionation, limitation of the dose delivered to the entire liver, and restriction of the high dose irradiation volume may afford protection. With the aim of studying the problems of hepatic radiation injury in humans, a project of liver irradiation in the dog is being conducted. Mongrel dogs are being conditioned, submitted to pre-irradiation studies (haemogram, blood chemistry, liver scan and biopsy), irradiated under conditions resembling human cancer therapy, and submitted to post-irradiation evaluation of the liver. Twenty-two dogs have been entered in the study but only four qualify for the evaluation of all the study parameters. It has been found that dogs are susceptible to liver irradiation damage similar to humans. The initial mortality has been high mainly due to non-radiation factors which are being kept under control at the present phase of the study. After the initial experiences, the study will involve variations in total dose and fractionation, and the addition of anticoagulant therapy for possible prevention of radiation liver injury. (author)

Accident prevention and security measures to prevent intentional harm and damage through nuclear energy

International Nuclear Information System (INIS)

Rauschning, D.

1984-01-01

The author explains the authorities' duty to provide for protection against intentional damage or physical harm through the use of nuclear energy. It belongs to the competence of the various authorities to define ways and means to afford protection, and to establish an appropriate network of provisions. There are provisions belonging to criminal law, those concerning liability and indemnity, and security regulations incorporated in the law on licensing and supervision. The author presents a detailed account of the law applicable and discusses the conflict of interests between governmental duties and intentions and the civil rights of the individual affected by the provisions. (HSCH) [de

PREVENTING THEFTS AND DAMAGE TO PROPERTY

CERN Document Server

2006-01-01

Discouraging thieves is the best way of protecting your property. On the eve of CERN's annual end-of-year closure, in your own interest, that of your colleagues and that of the Organization, we would strongly advise you to take the following precautions: MONEY, VALUABLES & KEYS: Do not leave money or valuables in your office or your lockers. Keys and spare keys must be taken away or kept in a safe place (please avoid supposedly 'safe hiding places' such as drawers, even if they are locked, metal boxes and flowers pots, all of which are well-known to burglars). Change lock codes regularly. Be careful if you have to leave your keys with a third party and make sure that they do not pass them on to anyone else. DOORS & WINDOWS: Lock office, workshop and meeting-room doors, etc. when you leave. Also make sure windows are properly shut, especially if they are easily accessible from outside. REPORTING INCIDENTS: Each theft solved could prevent another from being perpetrated. Please report thef...

Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage.

Science.gov (United States)

Rele, Aarti S; Mohile, R B

2003-01-01

Previously published results showed that both in vitro and in vivo coconut oil (CNO) treatments prevented combing damage of various hair types. Using the same methodology, an attempt was made to study the properties of mineral oil and sunflower oil on hair. Mineral oil (MO) was selected because it is extensively used in hair oil formulations in India, because it is non-greasy in nature, and because it is cheaper than vegetable oils like coconut and sunflower oils. The study was extended to sunflower oil (SFO) because it is the second most utilized base oil in the hair oil industry on account of its non-freezing property and its odorlessness at ambient temperature. As the aim was to cover different treatments, and the effect of these treatments on various hair types using the above oils, the number of experiments to be conducted was a very high number and a technique termed as the Taguchi Design of Experimentation was used. The findings clearly indicate the strong impact that coconut oil application has to hair as compared to application of both sunflower and mineral oils. Among three oils, coconut oil was the only oil found to reduce the protein loss remarkably for both undamaged and damaged hair when used as a pre-wash and post-wash grooming product. Both sunflower and mineral oils do not help at all in reducing the protein loss from hair. This difference in results could arise from the composition of each of these oils. Coconut oil, being a triglyceride of lauric acid (principal fatty acid), has a high affinity for hair proteins and, because of its low molecular weight and straight linear chain, is able to penetrate inside the hair shaft. Mineral oil, being a hydrocarbon, has no affinity for proteins and therefore is not able to penetrate and yield better results. In the case of sunflower oil, although it is a triglyceride of linoleic acid, because of its bulky structure due to the presence of double bonds, it does not penetrate the fiber, consequently resulting

Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

Energy Technology Data Exchange (ETDEWEB)

Bueno, Giselle Oliveira Vieira

2007-07-01

In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that

Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

Energy Technology Data Exchange (ETDEWEB)

Bueno, Giselle Oliveira Vieira

2007-07-01

In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that these errors do not

Assessment of radiation damage - the need for a multi-parametric and integrative approach with the help of both clinical and biological dosimetry

International Nuclear Information System (INIS)

Meineke, Viktor

2008-01-01

Full text: Accidental exposure to ionising radiation leads to a damage on different levels of the biological organization of the organism. Depending on exposure conditions, such as nature of radiation, time and affected organs and organ systems, the clinical endpoint of radiation damage and the resulting acute and chronic radiation syndromes may vary to a great extent. Exposure situations range from pure localised radiation scenarios and partial body exposures up to whole body exposures. Therefore clinical pictures vary from localized radiation injuries up to the extreme situation of a radiation-induced multi-organ involvement and failure requiring immediate, intensive and interdisciplinary medical treatment. These total different and complex clinical situations not only show up most different clinical diagnostic and therapeutic aspects but necessarily due to different levels of the underlying biological damage, biological indicators of effects may vary to a wide extent. This fact means that an exact assessment of the extent of radiation damage within individual patients can only be performed when taking into consideration both clinical signs and symptoms as well as different biological indicators. Among the clinical indicators, routine laboratory parameters such as blood counts and the documentation of clinical signs and symptoms (such as the METREPOL system) are the key parameters, whereas the dicentric assay, the gold standard for biological dosimetry, but also methods under development such as the gamma-H2Ax focus assay or the estimation of variations of gene expression have to be taken into account. Each method provides best results in different situations, or in other words, there are methods that work better in a specific exposure condition or at a given time of examination (e.g. time after exposure) than others. Some methods show up results immediately, others require days to weeks until results are available for clinical decision making. Therefore to

Modelo de identificación y caracterización de tramos de carreteras sin accidentes (tramos blancos. Aplicación a la red de autopistas de peaje españolas

Directory of Open Access Journals (Sweden)

de la Peña-González, E.

2015-12-01

Full Text Available The traditional approach to infrastructural safety follows the consideration of mitigation tools, such as the identification and management of black spots or road sections with high accident concentration, or preventing tools, as road safety audits and inspections. A complement to these tools is presented in this paper, from a new perspective: the consideration of road sections where, under similar conditions and similar risk exposure, there are no accidents (white road sections. A model has been calibrated to the Spanish toll motorways network, identifying the specific geometric parameters and traffic characteristics which have the highest influence in the occurrence of white sections with sufficient length, without accidents during a significant period of time: heavy vehicles traffic volume, with of the road section and speed.El planteamiento tradicional de análisis de la accidentalidad en carretera pasa por la consideración de herramientas paliativas, como son la identificación y gestión de los puntos negros o tramos de concentración de accidentes, o preventivas, como las auditorías o inspecciones de seguridad vial. En este artículo se presenta un complemento a estas herramientas, desde una perspectiva novedosa: la consideración de los tramos donde, bajo unas condiciones similares a las de otros tramos y una similar exposición al riesgo, no se producen accidentes (tramos blancos. Se resume el modelo que se ha calibrado para las autopistas de peaje españolas, identificando los parámetros específicos de la geometría de la vía y del tráfico que más influencia tienen en el hecho de que en algunos tramos de suficiente longitud, no se produzcan accidentes durante un periodo significativo de tiempo: el tráfico de pesados, al ancho de calzada y la velocidad de circulación.

An atypical case of successful resuscitation of an accidental profound hypothermia patient, occurring in a temperate climate.

LENUS (Irish Health Repository)

Coleman, E

2010-03-01

Cases of accidental profound hypothermia occur most frequently in cold, northern climates. We describe an atypical case, occurring in a temperate climate, where a hypothermic cardiac-arrested patient was successfully resuscitated using extracorporeal circulation (ECC).

Ultraviolet-B lethal damage on Pseudomonas aeruginosa

International Nuclear Information System (INIS)

Degiorgi, C.F.; Fernandez, R.O.; Pizarro, R.A.

1996-01-01

Pseudomonas aeruginosa has shown an increased sensitivity compared with that of Escherichia coli and Enterobacter cloacae, when they were exposed to 0.4 kJ/m2 of ultraviolet-B radiation. The rapid decay in cell viability observed in Pseudomonas aeruginosa after the irradiation was influenced by factors such as culture media and the presence of pyocyanine during the irradiation. The radioinduced lethal damage could be prevented by photoreactivating treatment, indicating that pyrimidine dimer formation was the mechanism causing bacterial death. The results indicate that several environmental conditions may act as protective agents against ultraviolet-B-induced damage

The Artificial, the Accidental, the Aesthetic…

Directory of Open Access Journals (Sweden)

Nicole Koltick

2015-11-01

Full Text Available How do we define, discuss or assess aesthetics within a contemporary philosophical framework? The indefiniteness that accompanies attempts to formalize a definition of the aesthetic is a primary focus of this paper. This lack of a definition has occupied philosophers for hundreds of years in attempts to delineate the boundaries of an elusively formless concept. This formlessness speaks to the incredibly evasive character of such a pervasive feature recognized in both natural and artificial systems, agents and artefacts. With the rapid growth of artificially intelligent systems and an astounding diversity in computational creativity, in what ways may we approach aesthetics? How is the aesthetic recognized, determined and produced? This paper seeks to critically engage issues of non-human agency, inter-object relations, and aesthetic theory in relation to computational entities and autonomous systems. The ability of these systems to operate outside of human cognitive limitations including thought patterns and constructions which may preclude alternative aesthetic outcomes, afford them in some ways limitless potential in relation to aesthetics. The designation of the accidental or provisional is utilized as an alternative approach to the production and assessment of aesthetic occurrences of the non-human.

Performance test of a portable TLD system for accidental doses

International Nuclear Information System (INIS)

Mihelic, M.; Stuhec, M.; Mitic, D.; Vekic, B.; Miljanic, S.; Ban, R.

2005-01-01

Full text: A portable TLD measuring system was constructed at the J. Stefan Institute many years ago, motivated by the thread of a catastrophic nuclear event. It was designed for fast measurements in accidental dosimetry mainly for military and civil protection use. The system consists of a robust portable measuring unit built for measurements in field conditions, sized about 40 cm in diameter and weighting 5 kg. Dosimeters are based on CaF 2 :Mn ceramic tablets closed in water resistant plastic housings. In original design producer assured measuring range from cGy to kGy. Specially designed energy compensating filters are used to satisfy requirements for energy response from 0,1 to 3 MeV. Stability of readings is maintained with the temperature stabilized light source. Measuring time for manually driven heating-reading cycle of one dosimeter is about 30 sec. Many systems of the type with sets of dosimeters were stored unused for some years in depositories of different institutions. Modernization of equipment in last years raised questions of applicability of such measurement systems for contemporary needs. The system was thus tested in a secondary standards dosimetry laboratory for compliance with up to date requirements for accidental individual monitoring. Dosimeter characteristics as repeatability, linearity and directional response were of particular interest. As a result of the tests, technical improvements are suggested to extent systems measuring capabilities in order to meet new standards. Possibilities of its use in different fields of dosimetry are discussed, where quick in field measurements of high doses is required as for example in medicine or in civil protection motivated by the new threads of terrorist attacks. (author)

Radioprotection against DNA damage by an extract of Indian green mussel, Perna viridis (L.)

Digital Repository Service at National Institute of Oceanography (India)

Kumaran, S.P.; Kutty, B.C.; Chatterji, A.; Parameswaran, P.S.; Mishra, K.P.

-irradiation Prevention of DNA damage both in plasmid and lymphocytes and cell death in lymphocytes appears correlated with reduction of oxidatively generated free radicals It is concluded that protection against radiation-induced cell death and DNA damage by MH...

Potential biological indicators of multi-organ damage: Application to radiation accident victims

International Nuclear Information System (INIS)

Bertho, J.M.; Souidi, M.; Gourmelon, P.

2009-01-01

Accidental irradiations induce a complex pathological situation, difficult to assess and to treat. However, recent results describing new biological indicators of radiation-induced damages such as Flt3-ligand, citrulline and oxy-sterol concentration in the plasma, together with results obtained in large animal models of high dose irradiation, allowed a better understanding of pathophysiological mechanisms induced by uncontrolled irradiations. This conducted to leave the classical paradigm of the acute radiation syndrome, described as the association of three individual syndromes, the hematopoietic syndrome, the gastro-intestinal syndrome and the cerebrovascular syndrome, in favour of a multiple organ dysfunction syndrome, with the implication of other organs and systems. Follow-up of victims from two recent radiation accidents brings a confirmation of the usefulness of the newly described biological indicators, and also a partial confirmation of this new concept of a multiple organ dysfunction syndrome. (authors)

On the corrosion behavior of zircaloy-4 in spent fuel pools under accidental conditions

International Nuclear Information System (INIS)

Lavigne, O.; Shoji, T.; Sakaguchi, K.

2012-01-01

Highlights: ► Corrosion behavior of oxidized Zr-4 in alkaline media in presence of chloride and radical forms. ► Generation of radical forms by sonolysis of water. ► Limited increase of the passive current densities under polarization with the increase of pH and the presence of radicals. ► Decrease of the passive range of oxidized Zr-4 with presence of Cl − (E pit ∼ 0.6 V SCE ). ► Decrease of the pitting potential when oxide layer is scratched or damaged (E pit ∼ 0.16 V SCE ). - Abstract: After zircaloy cladding tubes have been subjected to irradiation in the reactor core, they are stored temporarily in spent fuel pools. In case of an accident, the integrity of the pool may be affected and the composition of the coolant may change drastically. This was the case in Fukushima Daiichi in March 2011. Successive incidents have led to an increase in the pH of the coolant and to chloride contamination. Moreover, water radiolysis may occur owing to the remnant radioactivity of the spent fuel. In this study, we propose to evaluate the corrosion behavior of oxidized Zr-4 (in autoclave at 288 °C for 32 days) in function of the pH and the presence of chloride and radical forms. The generation of radicals is achieved by the sonolysis of the solution. It appears that the increase in pH and the presence of radicals lead to an increase in current densities. However, the current densities remain quite low (depending on the conditions, between 1 and 10 μA cm −2 ). The critical parameter is the presence of chloride ions. The chloride ions widely decrease the passive range of the oxidized samples (the pitting potential is measured around +0.6 V (vs. SCE)). Moreover, if the oxide layer is scratched or damaged (which is likely under accidental conditions), the pitting potential of the oxidized sample reaches the pitting potential of the non-oxidized sample (around +0.16 V (vs. SCE)), leaving a shorter stable passive range for the Zr-4 cladding tubes.

Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells

International Nuclear Information System (INIS)

Thierry, D.

1994-01-01

Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too

Smart accelerometer. [vibration damage detection

Science.gov (United States)

Bozeman, Richard J., Jr. (Inventor)

1994-01-01

The invention discloses methods and apparatus for detecting vibrations from machines which indicate an impending malfunction for the purpose of preventing additional damage and allowing for an orderly shutdown or a change in mode of operation. The method and apparatus is especially suited for reliable operation in providing thruster control data concerning unstable vibration in an electrical environment which is typically noisy and in which unrecognized ground loops may exist.