WorldWideScience

Sample records for prevalence puts searchers

  1. Job Searchers, Job Matches and the Elasticity of Matching

    NARCIS (Netherlands)

    Broersma, L.; van Ours, J.C.

    1998-01-01

    This paper stresses the importance of a specification of the matching function in which the measure of job matches corresponds to the measure of job searchers. In many empirical studies on the matching function this requirement has not been fulfilled because it is difficult to find information about

  2. Einstein the searcher his work explained from dialogues with Einstein

    CERN Document Server

    Moszkowski, Alexander

    2014-01-01

    This volume, first published in 1921, presents a series of portraits of Einstein, thus offering glimpses in the character and private reflections of the man who changed the course of modern science. Intended neither as a biography, nor as a résumé of Einsteinian physics, Einstein: The Searcher instead focusses on Einstein's relationship with the scientific project as he himself conceived it, and so is still of contemporary significance for those puzzled by the spirit of scientific enquiry.

  3. Opportunistic random searcher versus intentional search image user.

    Science.gov (United States)

    Garay, József; Varga, Zoltán; Móri, Tamás F; López, Inmaculada; Gámez, Manuel; Gallego, Juan R; Cabello, Tomás

    2018-02-20

    We consider two types of optimal foragers: a random searcher and a search image user. A search image user can find its desired prey with higher and undesired prey with lower probability than a random searcher. Our model considers the density-dependent travelling time and the time duration of reproduction (oviposition). In the framework of optimal foraging theory for one predator-two prey systems, we find that there are ranges of prey densities in which the search image user has a higher net energy intake, and there are other ranges of prey densities in which the random searcher has higher net energy intake. The damsel bug Nabis pseudoferus Remane (Hemiptera: Nabidae) is a generalist predator rather than an omnivore. This species has a wide range of arthropod prey (predominantly insects and mites). Several aspects of the biology of this species have been studied, especially its cannibalistic behaviour, which is a quite important feature because N. pseudoferus is often used as a biological control agent against lepidopteran pests in greenhouse crops. Experimentally, we found that Nabis is a search image user in the above sense.

  4. Characterizing Internet searchers of smoking cessation information.

    Science.gov (United States)

    Cobb, Nathan K; Graham, Amanda L

    2006-09-19

    The Internet is a viable channel to deliver evidence-based smoking cessation treatment that has the potential to make a large population impact on reducing smoking prevalence. There is high demand for smoking cessation information and support on the Internet. Approximately 7% (10.2 million) of adult American Internet users have searched for information on quitting smoking. Little is known about these individuals, their smoking status, what type of cessation services they are seeking on the Internet, or how frequently these searches for cessation information are conducted. The primary goal of this study was to characterize individuals who search for smoking cessation information on the Internet to determine appropriate triage and treatment strategies. The secondary goal was to estimate the incidence of searches for cessation information using publicly available search engine data. We recruited individuals who clicked on a link to a leading smoking cessation website (QuitNet) from within the results of a search engine query. Individuals were "intercepted" before seeing the QuitNet home page and were invited to participate in the study. Those accepting the invitation were routed to an online survey about demographics, smoking characteristics, preferences for specific cessation services, and Internet search patterns. To determine the generalizability of our sample, national datasets on search engine usage patterns, market share, and keyword rankings were examined. These datasets were then used to estimate the number of queries for smoking cessation information each year. During the 10-day study period, 2265 individuals were recruited and 29% (N = 655) responded. Of these, 59% were female and overall tended to be younger than the previously characterized general Internet population. Most (76%) respondents were current smokers; 17% had quit within the last 7 days, and 7% had quit more than 7 days ago. Slightly more than half of active smokers (53%) indicated that they

  5. Super Searchers Go to the Source: The Interviewing and Hands-On Information Strategies of Top Primary Researchers--Online, on the Phone, and in Person. Super Searchers.

    Science.gov (United States)

    Sacks, Risa

    This book presents interviews with 12 of the best primary researchers in the business. These research professionals reveal their strategies for integrating online and offline resources, identifying experts, and getting past gatekeepers to obtain information that exists only in someone's head. Topics include how searchers use a combination of…

  6. Using ‘search transitions’ to study searchers investment of effort: experiences with client and server side logging

    OpenAIRE

    Pharo, Nils; Nordlie, Ragnar

    2013-01-01

    We are investigating the value of using the concept ‘search transition’ for studying effort invested in information search processes. In this paper we present findings from a comparative study of data collected from client and server side loggings. The purpose is to see what factors of effort can be captured from the two logging methods. The data stems from studies of searchers interaction with an XML information retrieval system. The searchers interaction was simultaneously logged by a scree...

  7. Multiobjective memetic estimation of distribution algorithm based on an incremental tournament local searcher.

    Science.gov (United States)

    Yang, Kaifeng; Mu, Li; Yang, Dongdong; Zou, Feng; Wang, Lei; Jiang, Qiaoyong

    2014-01-01

    A novel hybrid multiobjective algorithm is presented in this paper, which combines a new multiobjective estimation of distribution algorithm, an efficient local searcher and ε-dominance. Besides, two multiobjective problems with variable linkages strictly based on manifold distribution are proposed. The Pareto set to the continuous multiobjective optimization problems, in the decision space, is a piecewise low-dimensional continuous manifold. The regularity by the manifold features just build probability distribution model by globally statistical information from the population, yet, the efficiency of promising individuals is not well exploited, which is not beneficial to search and optimization process. Hereby, an incremental tournament local searcher is designed to exploit local information efficiently and accelerate convergence to the true Pareto-optimal front. Besides, since ε-dominance is a strategy that can make multiobjective algorithm gain well distributed solutions and has low computational complexity, ε-dominance and the incremental tournament local searcher are combined here. The novel memetic multiobjective estimation of distribution algorithm, MMEDA, was proposed accordingly. The algorithm is validated by experiment on twenty-two test problems with and without variable linkages of diverse complexities. Compared with three state-of-the-art multiobjective optimization algorithms, our algorithm achieves comparable results in terms of convergence and diversity metrics.

  8. Multiobjective Memetic Estimation of Distribution Algorithm Based on an Incremental Tournament Local Searcher

    Directory of Open Access Journals (Sweden)

    Kaifeng Yang

    2014-01-01

    Full Text Available A novel hybrid multiobjective algorithm is presented in this paper, which combines a new multiobjective estimation of distribution algorithm, an efficient local searcher and ε-dominance. Besides, two multiobjective problems with variable linkages strictly based on manifold distribution are proposed. The Pareto set to the continuous multiobjective optimization problems, in the decision space, is a piecewise low-dimensional continuous manifold. The regularity by the manifold features just build probability distribution model by globally statistical information from the population, yet, the efficiency of promising individuals is not well exploited, which is not beneficial to search and optimization process. Hereby, an incremental tournament local searcher is designed to exploit local information efficiently and accelerate convergence to the true Pareto-optimal front. Besides, since ε-dominance is a strategy that can make multiobjective algorithm gain well distributed solutions and has low computational complexity, ε-dominance and the incremental tournament local searcher are combined here. The novel memetic multiobjective estimation of distribution algorithm, MMEDA, was proposed accordingly. The algorithm is validated by experiment on twenty-two test problems with and without variable linkages of diverse complexities. Compared with three state-of-the-art multiobjective optimization algorithms, our algorithm achieves comparable results in terms of convergence and diversity metrics.

  9. Nonstationary dynamics of encounters: Mean valuable territory covered by a random searcher

    Science.gov (United States)

    Campos, Daniel; Bartumeus, Frederic; Méndez, Vicenç

    2017-09-01

    Inspired by recent experiments on the organism Caenorhabditis elegans we present a stochastic problem to capture the adaptive dynamics of search in living beings, which involves the exploration-exploitation dilemma between remaining in a previously preferred area and relocating to new places. We assess the question of search efficiency by introducing a new magnitude, the mean valuable territory covered by a Browinan searcher, for the case where each site in the domain becomes valuable only after a random time controlled by a nonhomogeneous rate which expands from the origin outwards. We explore analytically this magnitude for domains of dimensions 1, 2, and 3 and discuss the theoretical and applied (biological) interest of our approach. As the main results here, we (i) report the existence of some universal scaling properties for the mean valuable territory covered as a function of time and (ii) reveal the emergence of an optimal diffusivity which appears only for domains in two and higher dimensions.

  10. Searchers' relevance judgments and criteria in evaluating Web pages in a learning style perspective

    DEFF Research Database (Denmark)

    Papaeconomou, Chariste; Zijlema, Annemarie F.; Ingwersen, Peter

    2008-01-01

    The paper presents the results of a case study of searcher's relevance criteria used for assessments of Web pages in a perspective of learning style. 15 test persons participated in the experiments based on two simulated work tasks that provided cover stories to trigger their information needs. Two...... learning styles were examined: Global and Sequential learners. The study applied eye-tracking for the observation of relevance hot spots on Web pages, learning style index analysis and post-search interviews to gain more in-depth information on relevance behavior. Findings reveal that with respect to use......, they are statistically insignificant. When interviewed in retrospective the resulting profiles tend to become even similar across learning styles but a shift occurs from instant assessments with content features of web pages replacing topicality judgments as predominant relevance criteria....

  11. Filling of a Poisson trap by a population of random intermittent searchers

    KAUST Repository

    Bressloff, Paul C.

    2012-03-01

    We extend the continuum theory of random intermittent search processes to the case of N independent searchers looking to deliver cargo to a single hidden target located somewhere on a semi-infinite track. Each searcher randomly switches between a stationary state and either a leftward or rightward constant velocity state. We assume that all of the particles start at one end of the track and realize sample trajectories independently generated from the same underlying stochastic process. The hidden target is treated as a partially absorbing trap in which a particle can only detect the target and deliver its cargo if it is stationary and within range of the target; the particle is removed from the system after delivering its cargo. As a further generalization of previous models, we assume that up to n successive particles can find the target and deliver its cargo. Assuming that the rate of target detection scales as 1/N, we show that there exists a well-defined mean-field limit N→ in which the stochastic model reduces to a deterministic system of linear reaction-hyperbolic equations for the concentrations of particles in each of the internal states. These equations decouple from the stochastic process associated with filling the target with cargo. The latter can be modeled as a Poisson process in which the time-dependent rate of filling λ(t) depends on the concentration of stationary particles within the target domain. Hence, we refer to the target as a Poisson trap. We analyze the efficiency of filling the Poisson trap with n particles in terms of the waiting time density f n(t). The latter is determined by the integrated Poisson rate μ(t)=0tλ(s)ds, which in turn depends on the solution to the reaction-hyperbolic equations. We obtain an approximate solution for the particle concentrations by reducing the system of reaction-hyperbolic equations to a scalar advection-diffusion equation using a quasisteady-state analysis. We compare our analytical results for the

  12. Shot-put kinematics

    Science.gov (United States)

    DeLuca, R.

    2005-11-01

    The problem of the optimum throw in the shot-put discipline is analysed by relaxing the assumption that the height H, from which the athlete releases the shot, does not depend on the angle θ which the arm of the putter makes with the horizontal axis. In this context, the kinematics of the shot-put is studied and results are compared with the traditional analysis, which considers the height H, the angle θ and the modulus V0 of the initial velocity of the metal sphere as independent parameters.

  13. Putting Participation into Practice

    African Journals Online (AJOL)

    a research project in which I partic- ipated in ... A list of combined themes was compiled and a model was constructed to depict the themes and their interrelatedness. ... towards facilitating the personal growth and development of patients (to nurture self-reliance). (SA Fam Pract 2004;46(5): 31-36). Original Research. Putting ...

  14. Prevalence

    Directory of Open Access Journals (Sweden)

    Ahmed E. Mansour

    2013-07-01

    Conclusion: The prevalence of spontaneous bacterial pleuritis in the studied group of patients with hepatic hydrothorax was 14.3%. Patients with advanced liver disease, low pleural fluid protein, or SBP are at risk for spontaneous bacterial pleuritis.

  15. Putting politics first.

    Science.gov (United States)

    Hacker, Jacob S

    2008-01-01

    The greatest lesson of the failure of comprehensive health reform in the early 1990s is that politics comes first. Even the best-laid policy plans are worthless if they lack the political support to pass. Putting politics first means avoiding the overarching mistake of the Clinton reformers: envisioning a grand policy compromise rather than hammering out a real political compromise. It also means addressing the inevitable fears of those who believe that they are well protected by our eroding employment-based system. And it means formulating political strategies that are premised on the contemporary realities of the hyperpolarized U.S. political environment, rather than wistfully recalled images of the bipartisan politics of old.

  16. Put order picking system

    Directory of Open Access Journals (Sweden)

    Đurđević Dragan D.

    2014-01-01

    Full Text Available Nowadays the warehouse is very important logistic component of the supply chain, where order-picking systems have important role. Due to the significant impact on logistics performance permanent goals are to increase efficiency and reduce the cost of these systems. To achieve these goals, there are different researches, and their success is determined by the achieved performances. Performances order picking process are dependent on the applied technology concepts of order-picking system, as well as the ways in which it is organized and managed. In addition to the standard conceptions (the man to good and good to the man is one of the newer, so-called. 'put' system - the inverse order-picking. The aim of this paper is to describe this concept, point out its core strengths and weaknesses and provide a basis that may be of importance in the development of warehouse technological solutions and application of this order-picking systems concept.

  17. Putting instruction sequences into effect

    NARCIS (Netherlands)

    Bergstra, J.A.

    2011-01-01

    An attempt is made to define the concept of execution of an instruction sequence. It is found to be a special case of directly putting into effect of an instruction sequence. Directly putting into effect of an instruction sequences comprises interpretation as well as execution. Directly putting into

  18. Prevalence

    Directory of Open Access Journals (Sweden)

    Mohammed Al-Darwish

    2014-07-01

    Conclusion: Results indicated that dental caries prevalence among school children in Qatar has reached critical levels, and is influenced by socio-demographic factors. The mean decayed, missing, and filled teeth values obtained in this study were the second highest detected in the Eastern Mediterranean region.

  19. Prevalence

    Directory of Open Access Journals (Sweden)

    Jeanesse Scerri

    2013-09-01

    Full Text Available Methicillin-resistant Staphylococcus aureus (MRSA is a major nosocomial pathogen worldwide. Malta is one of the countries with the highest MRSA prevalence in Europe, as identified from hospital blood cultures [1]. However, community prevalence of MRSA has never previously been investigated. This study aimed at establishing the prevalence of community MRSA nasal colonization in Maltese individuals and identifying the clonal characteristics of the detected isolates. Nasal swabs were collected from 329 healthy individuals who were also asked to complete a brief questionnaire about risk factors commonly associated with MRSA carriage and infection. The swabs were transported and enriched in a nutrient broth supplemented with NaCl. The presence of MRSA was then determined by culturing on MRSA Select chromogenic agar and then confirming by several assays, including catalase, coagulase and PBP2a agglutination tests. The isolates were assayed for antibiotic susceptibilities and typed by microarray analysis to determine the clonal characteristics of each strain. The prevalence of MRSA nasal colonization in the healthy Maltese population was found to be 8.81% (95% confidence interval [CI], 5.75–11.87%, much higher than that found in other studies carried out in several countries. No statistical association was found between MRSA carriage and demographics or risk factors; however, this was hindered by the small sample size. Almost all the isolates were fusidic-acid resistant. The majority were found to belong to a local endemic clone (CC5 which seems to be replacing the previously prevalent European clone UK-EMRSA-15 in the country. A new clone (CC50-MRSA-V was also characterized. The presence of such a significant community reservoir of MRSA increases the burdens already faced by the local healthcare system to control the MRSA epidemic. Colonization of MRSA in otherwise healthy individuals may represent a risk for endogenous infection and transmission to

  20. Convergent Validity of the PUTS

    Directory of Open Access Journals (Sweden)

    Valerie Cathérine Brandt

    2016-04-01

    Full Text Available Premonitory urges are a cardinal feature in Gilles de la Tourette syndrome. Severity of premonitory urges can be assessed with the Premonitory Urge for Tic Disorders Scale (PUTS. However, convergent validity of the measure has been difficult to assess due to the lack of other urge measures.We investigated the relationship between average real-time urge intensity assessed by an in-house developed real-time urge monitor, measuring urge intensity continuously for 5mins on a visual analogue scale, and general urge intensity assessed by the PUTS in 22 adult Tourette patients (mean age 29.8+/- 10.3; 19 male. Additionally, underlying factors of premonitory urges assessed by the PUTS were investigated in the adult sample using factor analysis and were replicated in 40 children and adolescents diagnosed with Tourette syndrome (mean age 12.05 +/- 2.83 SD, 31 male.Cronbach’s alpha for the PUTS10 was acceptable (α = .79 in the adult sample. Convergent validity between average real-time urge intensity scores (as assessed with the real-time urge monitor and the 10-item version of the PUTS (r = .64 and the 9-item version of the PUTS (r = .66 was good. A factor analysis including the 10 items of the PUTS and average real-time urge intensity scores revealed three factors. One factor included the average real-time urge intensity score and appeared to measure urge intensity, while the other two factors can be assumed to reflect the (sensory quality of urges and subjective control, respectively. The factor structure of the 10 PUTS items alone was replicated in a sample of children and adolescents.The results indicate that convergent validity between the PUTS and the real-time urge assessment monitor is good. Furthermore, the results suggest that the PUTS might assess more than one dimension of urges and it may be worthwhile developing different sub-scales of the PUTS assessing premonitory urges in terms of intensity and quality, as well as subjectively

  1. Putting Emotional Intelligence To Work

    CERN Document Server

    Ryback, David

    2012-01-01

    Putting Emotional Intelligence to Work offers a new paradigm of communication for the 21st-century workplace. Beginning with the thoughts of communication pioneer Carl Rogers, this book covers the origins and history of emotional intelligence, why it is essential at this point in the changing marketplace, how to delegate and negotiate more effectively, and how to change yourself to become a more effective player. An EQ (Emotional Quotient) survey helps you determine where you are on the scale of executive intelligence. Putting Emotional Intelligence to Work leaves you with a greater understand

  2. Heating being put into service

    CERN Multimedia

    2016-01-01

    The SMB-SE group would like to inform you that, the central heating will start this year, on Monday 3 October 2016, and will be progressively and depending on the weather forecast put into service throughout. All buildings will have heating within the following few days. Thank you for your understanding. The CERN heating team SMB-SE

  3. Putting Pow into Art Instruction

    Science.gov (United States)

    Berkowitz, Jay; Packer, Todd

    2004-01-01

    How would you like to put some "Pow!" into your art instruction? A lesson in comic books--history, design, story, and production--can make your classes come alive. The authors present a new approach to using comics to build artistic skills and involve students in art appreciation. Why Comics? Many art teachers have students who say, "I hate art!"…

  4. Put numbers on the sustainability

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky

    2014-01-01

    life cycle Environmental sustainability encompasses multiple types of environmental impact ranging from the global scale like climate change and stratospheric ozone depletion over regional impacts associated with air pollution impacts causing acidification, photochemical ozone formation and particle...... exposure of humans, to the local impacts associated with physical transformation of land and extraction of water. Chemicals can cause toxic impacts to humans and ecosystems on all scales. All these impacts need to be quantified if we want to put numbers on sustainability. The life cycle perspective......Sustainability is about meeting the needs of the present without compromising the possibilities for our future generations to meet their needs and is commonly perceived as comprising three dimensions – a social, an economic and an environmental dimension, e.g. in the triple bottom line thinking...

  5. Putting science on the agenda

    CERN Multimedia

    2012-01-01

    The job of CERN Director-General comes with a lot of responsibility, and that’s particularly true today. We’re living through a period of unique circumstances for science. Positive indicators, such as a renewal of interest in physical sciences at the University level and unprecedented public interest in the LHC, are aligning with storm clouds in the form of a prolonged economic crisis that will put downward pressure on everyone’s budgets.   That means that science has to make its voice heard if it’s to preserve support, and if it wants to be in a position to play the role it must in navigating the major societal challenges of our time. For that reason, I have been a fairly rare sight at CERN of late. Last week, I was in Davos for the annual meeting of the World Economic Forum. It was my second time at Davos, and I used the opportunity to argue that science should be more closely linked to the political thread of the meeting. I think my argument was he...

  6. Outback is put through its paces.

    Science.gov (United States)

    2017-06-03

    Ashley Rubens, winner of the competition to find the BVA member facing the toughest driving conditions in the UK, has spent the past few months putting a Subaru Outback through its paces. British Veterinary Association.

  7. The Leadership Puzzle, Putting the Pieces Together

    OpenAIRE

    Nelson, Cindy

    2017-01-01

    This curriculum relates leadership to putting together a puzzle, including the five steps of leadership, understanding the value of each person in the leadership process/puzzle, learning the four corners of leadership: communication, commitment, cooperation, and character.

  8. Making Life Easier for the Visually Impaired Web Searcher: It Is Now Clearer How This Should and Can Be Done, but Implementation Lags. A Review of: Sahib, N. G., Tombros, A., & Stockman, T. (2012. A comparative analysis of the information-seeking behavior of visually impaired and sighted searchers. Journal of the American Society for Information Science and Technology, 63(2, 377–391. doi: 10.1002/asi.21696

    Directory of Open Access Journals (Sweden)

    R. Laval Hunsucker

    2013-03-01

    Full Text Available Objective – To determine how the behaviour of visually impaired persons significantly differs from that of sighted persons in the carrying out of complex search tasks on the internet.Design – A comparative observational user study, plus semi-structured interviews.Setting – Not specified.Subjects – 15 sighted and 15 visually impaired persons, all of them experienced and frequent Internet search engine users, of both sexes and varying in age from early twenties to mid-fifties.Methods – The subjects carried out self selected complex search tasks on their own equipment and in their own familiar environments. The investigators observed this activity to some extent directly, but for the most part via video camera, through use of a screen-sharing facility, or with screen-capture software. They distinguished four stages of search task activity: query formulation, search results exploration, query reformulation, and search results management. The visually impaired participants, of whom 13 were totally blind and two had only marginal vision, were all working with text-to-speech screen readers and depended exclusively for all their observed activity on those applications’ auditory output. For data analysis, the investigators devised a grounded-theory based coding scheme. They employed a search log format for deriving further quantitative data which they later controlled for statistical significance (two-tailed unpaired t-test; p Main Results – The investigators found significant differences between the sighted participants’ search behaviour and that of the visually impaired searchers. The latter displayed a clearly less “orienteering” (O'Day & Jeffries, 1993 disposition and style, more often starting out with already relatively long and comprehensive combinations of relatively precise search terms; “their queries were more expressive” (p. 386. They submitted fewer follow-up queries, and were considerably less inclined to attempt

  9. THE IDIOM OF KRIVI PUT KOD SENJA

    Directory of Open Access Journals (Sweden)

    Ankica Čilaš Šimpraga

    2007-01-01

    Full Text Available The idiom of Krivi Put kod Senja is part of West-Štokavian dialect. The basics of phonological, morphological, syntactic and lexical characteristics of idiom are considered in this article. Research confirmed common features with idioms of Bunjevo beyond Velebit’s part of hinterland of Senj.

  10. DIST/AVC Out-Put Definition.

    Science.gov (United States)

    Wilkinson, Gene L.

    The first stage of development of a management information system for DIST/AVC (Division of Instructional Technology/Audio-Visual Center) is the definition of out-put units. Some constraints on the definition of output units are: 1) they should reflect goals of the organization, 2) they should reflect organizational structure and procedures, and…

  11. Stereotype Fit Effects for Golf Putting Nonexperts.

    Science.gov (United States)

    Grimm, Lisa R; Lewis, Benjamin; Maddox, W Todd; Markman, Arthur B

    2016-02-01

    Research has connected stereotype threat and regulatory fit by showing improved performance for individuals with negative stereotypes when they focused on minimizing potential losses. In the current study, non-Black participants, who were non-experts at golf putting, were told that a golf-putting task was diagnostic of natural athletic ability (i.e., negative stereotype) or sports intelligence (i.e., positive stereotype). Participants tried to maximize earned points or minimize lost points assigned after every putt, which was calculated based on the distance to a target. We demonstrate better performance for participants experiencing a fit between their global task stereotype and the task goal, and argue that regulatory fit allows for increased attention on the strategies beneficial for task performance. Interestingly, we find that performance of individuals high in working memory capacity suffers greatly when those individuals experience a regulatory mismatch.

  12. Putting Opportunism in the Back Seat

    DEFF Research Database (Denmark)

    Foss, Nicolai; Weber, Libby

    2013-01-01

    TCE and its applications in management research put more emphasis on opportunism than on bounded rationality. By augmenting the bounded rationality assumption to include interpretive limitations, we show that there are sources of costly conflict that are not rooted in opportunism. Moreover, we sh...... that bounded rationality may drive opportunism. All hierarchal forms are inherently subject to specific bounded-rationality-based conflicts, thus have different capacities to mitigate bounded-rationality-based transaction costs....

  13. Putting Opportunism in the Back Seat

    DEFF Research Database (Denmark)

    Foss, Nicolai; Weber, Libby

    2013-01-01

    TCE and its applications in management research put more emphasis on opportunism than on bounded rationality. By augmenting the bounded rationality assumption to include interpretive limitations, we show that there are sources of costly conflict that are not rooted in opportunism. Moreover, we show...... that bounded rationality may drive opportunism. All hierarchal forms are inherently subject to specific bounded-rationality-based conflicts, thus have different capacities to mitigate bounded-rationality-based transaction costs....

  14. Antidepressants & suicide: putting the risk in perspective.

    Science.gov (United States)

    Howland, Robert H

    2007-07-01

    Suicidal thoughts are a symptom of depression, and completed suicide is a tragic complication of depressive illness. Although pharmacotherapy is effective for the treatment of depression, the U.S. Food and Drug Administration has ordered that all antidepressant medications carry a warning indicating that they are associated with an increased risk of suicidal thinking, feeling, and behavior in children, adolescents, and young adults. These warnings have received much attention in the general media and have caused much controversy and debate about the relative safety of these commonly used drugs and the appropriateness of their use, especially in younger patients. In this article, I will discuss this issue with the goal of putting the risk in perspective.

  15. Managing coherence via put/get windows

    Energy Technology Data Exchange (ETDEWEB)

    Blumrich, Matthias A [Ridgefield, CT; Chen, Dong [Croton on Hudson, NY; Coteus, Paul W [Yorktown Heights, NY; Gara, Alan G [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Heidelberger, Philip [Cortlandt Manor, NY; Hoenicke, Dirk [Ossining, NY; Ohmacht, Martin [Yorktown Heights, NY

    2012-02-21

    A method and apparatus for managing coherence between two processors of a two processor node of a multi-processor computer system. Generally the present invention relates to a software algorithm that simplifies and significantly speeds the management of cache coherence in a message passing parallel computer, and to hardware apparatus that assists this cache coherence algorithm. The software algorithm uses the opening and closing of put/get windows to coordinate the activated required to achieve cache coherence. The hardware apparatus may be an extension to the hardware address decode, that creates, in the physical memory address space of the node, an area of virtual memory that (a) does not actually exist, and (b) is therefore able to respond instantly to read and write requests from the processing elements.

  16. Managing coherence via put/get windows

    Science.gov (United States)

    Blumrich, Matthias A [Ridgefield, CT; Chen, Dong [Croton on Hudson, NY; Coteus, Paul W [Yorktown Heights, NY; Gara, Alan G [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Heidelberger, Philip [Cortlandt Manor, NY; Hoenicke, Dirk [Ossining, NY; Ohmacht, Martin [Yorktown Heights, NY

    2011-01-11

    A method and apparatus for managing coherence between two processors of a two processor node of a multi-processor computer system. Generally the present invention relates to a software algorithm that simplifies and significantly speeds the management of cache coherence in a message passing parallel computer, and to hardware apparatus that assists this cache coherence algorithm. The software algorithm uses the opening and closing of put/get windows to coordinate the activated required to achieve cache coherence. The hardware apparatus may be an extension to the hardware address decode, that creates, in the physical memory address space of the node, an area of virtual memory that (a) does not actually exist, and (b) is therefore able to respond instantly to read and write requests from the processing elements.

  17. Proline dehydrogenase activity of the transcriptional repressor PutA is required for induction of the put operon by proline.

    Science.gov (United States)

    Muro-Pastor, A M; Maloy, S

    1995-04-28

    The proline utilization (put) operon from Salmonella typhimurium consists of the putP gene, encoding a proline transporter, and the putA gene, encoding an enzyme with both proline dehydrogenase and 1-pyrroline-5-carboxylate dehydrogenase activities. In addition to these two enzymatic activities, the PutA protein is a transcriptional repressor that regulates the expression of putP and putA in response to the availability of proline. We report the isolation of super-repressor mutants of PutA that decrease expression from the putA promoter in the presence or absence of proline. None of the mutants exhibited increased affinity for the DNA in the put regulatory region in vitro. Although DNA binding by wild-type PutA was prevented by the addition of proline and an artificial electron acceptor, DNA binding by the two strongest super-repressors was not prevented under identical conditions. The proline dehydrogenase activity of the purified mutant proteins showed altered kinetic properties (increased Km(Pro), reduced Vmax, or a completely null phenotype). The observation that these mutations simultaneously affect induction by proline and proline dehydrogenase activity suggests that a single proline-binding site is involved in both proline dehydrogenase activity and induction of the expression of the put operon. Furthermore, the results indicate that the proline dehydrogenase activity of PutA is essential for induction of the put operon by proline.

  18. Putting women’s eyesight first

    Directory of Open Access Journals (Sweden)

    Damian Facciolo

    2016-07-01

    Full Text Available Two-thirds of blindness and visual impairment occurs in women, and recent prevalence surveys in Vietnam and China show an imbalance in the coverage of services across some areas. We know that, compared to men, women account for the greater burden of blindness from cataract. Women and girls face numerous barriers in accessing eye care services and are less likely to utilise them.

  19. Tourism's collapse puts Gambian women at risk.

    Science.gov (United States)

    Coker, M S

    1995-06-01

    Despite efforts of the Gambian government, which established a ministry in 1981 that would tackle gender issues, improve women's health, and promote empowerment, women are underrepresented in government and business, and 84% are illiterate. Child mortality is among the highest in Africa; 134 children per 1000 die before their fifth birthday. In the mid-1980s austerity measures adopted by the World Bank and IMF left the ministry without funds. Rice and vegetable production, the main source of income for women, fell in the 1990s. In 1994, paddy production dropped 23% from the previous year; this was due to a lack of technical and financial assistance. The collapse of tourism with Capt. Yahya Jammeh's seizure of power has put prostitutes catering to tourists out of work, but women who have lost jobs in the hotel industry may be pushed into local prostitution to survive. The impact of this on the HIV/AIDS epidemic is unclear. Although Gambia is one of the world's most aid-dependent countries (more than a quarter of the GNP before the coup), corruption and mismanagement in the nongovernmental sector is widespread. The director of the Women in Development Programme, a $15m World Bank project, was forced to resign over allegations of fraud. The political process sidelines women; only village chiefs, who are traditionally men, are allowed to vote when new heads are elected.

  20. Putting in place the LHC computing organization

    CERN Multimedia

    Akesson, T

    2001-01-01

    Following the CERN review of computing, the ball is in the able hands of the CERN directorate to translate the review recommendations into the implementation of a LHC computing organization. From the ATLAS point of view it is rather clear what is needed: A credible set-up that can get into place the total computing infrastructure to match ATLAS global computing requirements, and not just at CERN. The next six months will demonstrate if CERN is on a good track to get operational an organization that can tackle this global challenge. CERN put forward to the 15th of June Council a paper that invites comments on a LHC Computing Grid Project as part of the CERN base program. In particular, it asked for new resources, of 25+25 MCHF, for CERN to build the CERN-part of a prototype that should be matched to the need of the experiments for the forthcoming data challenges. The intention of CERN now is to discuss with member-states in July to establish a sufficient resource-base to get approval at the September Commit...

  1. A Call-Put Duality for Perpetual American Options

    OpenAIRE

    Alfonsi, Aurélien; Jourdain, Benjamin

    2006-01-01

    International audience; It is well known that in models with time-homogeneous local volatility functions and constant interest and dividend rates, the European Put prices are transformed into European Call prices by the simultaneous exchanges of the interest and dividend rates and of the strike and spot price of the underlying. This paper investigates such a Call Put duality for perpetual American options. It turns out that the perpetual American Put price is equal to the perpetual American C...

  2. Neutrons put the brakes on stress

    International Nuclear Information System (INIS)

    Gill, Katynna

    2006-01-01

    Don't you hate it when you're driving along, put your foot on the brake and feel that juddering feeling through the pedal? It happens when the disc brake rotors become distorted through normal use of the brakes. To the car manufacturing industry it's called r unout , and is a multimillion dollar warranty problem each year. Not to mention a pain for drivers! Dr Maurice Ripley and Dr Oliver Kirstein from the Australian Nuclear Science and Technology Organisation (ANSTO) wanted to figure out whether runout is caused by residual stresses from the manufacturing process or by normal use of the brake, so they decided to test and compare a used and new brake disc. 'To picture what metal looks like at the atomic level, imagine spheres stacked evenly around each other in all three dimensions,' explained Kirstein. T he spheres represent atoms in the metal and the structure is called a metallic lattice.' We're familiar with the idea that metal expands when it gets hot - the atoms get excited with the heat and have the energy to move further away from each other, so spaces between the atoms in the lattice get larger. 'When parts of the metal are heated up and cool down at different rates, you may end up with a distorted lattice with some parts expanded and others not,' explained Kirstein. 'This unevenness in the lattice creates residual stress.' While a bunch of methods were available to test the discs, Kirstein and Ripley picked neutrons from ANSTO's HIFAR (High Flux Australian Reactor) as their tool of choice. 'Neutrons allow us to look at the inside of the metal without damaging it,' said Kirstein. 'They can penetrate through the iron, so we were able to take measurements at a series of points at different depths through the brake disc.' Word around the car industry is that when residual stresses are relaxed through heating of the brake disc during use, the discs could potentially distort, causing the runout and that juddering feeling. But everyone was clueless as to what

  3. Effect of Putting Grip on Eye and Head Movements During the Golf Putting Stroke

    Directory of Open Access Journals (Sweden)

    George K. Hung

    2003-01-01

    Full Text Available The objective of this article is to determine the effect of three different putting grips (conventional, cross-hand, and one-handed on variations in eye and head movements during the putting stroke. Seven volunteer novice players, ranging in age from 21 to 22 years, participated in the study. During each experimental session, the subject stood on a specially designed platform covered with artificial turf and putted golf balls towards a standard golf hole. The three different types of grips were tested at two distances: 3 and 9 ft. For each condition, 20 putts were attempted. For each putt, data were recorded over a 3-s interval at a sampling rate of 100 Hz. Eye movements were recorded using a helmet-mounted eye movement monitor. Head rotation about an imaginary axis through the top of the head and its center-of-rotation was measured by means of a potentiometer mounted on a fixed frame and coupled to the helmet. Putter-head motion was measured using a linear array of infrared phototransistors embedded in the platform. The standard deviation (STD, relative to the initial level was calculated for eye and head movements over the duration of the putt (i.e., from the beginning of the backstroke, through the forward stroke, to impact. The averaged STD for the attempted putts was calculated for each subject. Then, the averaged STDs and other data for the seven subjects were statistically compared across the three grip conditions. The STD of eye movements were greater (p < 0.1 for conventional than cross-hand (9 ft and one-handed (3 and 9 ft grips. Also, the STD of head movements were greater (p < 0.1; 3 ft for conventional than cross-hand and one-handed grips. Vestibulo-ocular responses associated with head rotations could be observed in many 9 ft and some 3 ft putts. The duration of the putt was significantly longer (p < 0.05; 3 and 9 ft for the one-handed than conventional and cross-hand grips. Finally, performance, or percentage putts made, was

  4. Effect of putting grip on eye and head movements during the golf putting stroke.

    Science.gov (United States)

    Hung, George K

    2003-03-24

    The objective of this article is to determine the effect of three different putting grips (conventional, cross-hand, and one-handed) on variations in eye and head movements during the putting stroke. Seven volunteer novice players, ranging in age from 21 to 22 years, participated in the study. During each experimental session, the subject stood on a specially designed platform covered with artificial turf and putted golf balls towards a standard golf hole. The three different types of grips were tested at two distances: 3 and 9 ft. For each condition, 20 putts were attempted. For each putt, data were recorded over a 3-s interval at a sampling rate of 100 Hz. Eye movements were recorded using a helmet-mounted eye movement monitor. Head rotation about an imaginary axis through the top of the head and its center-of-rotation was measured by means of a potentiometer mounted on a fixed frame and coupled to the helmet. Putter-head motion was measured using a linear array of infrared phototransistors embedded in the platform. The standard deviation (STD, relative to the initial level) was calculated for eye and head movements over the duration of the putt (i.e., from the beginning of the backstroke, through the forward stroke, to impact). The averaged STD for the attempted putts was calculated for each subject. Then, the averaged STDs and other data for the seven subjects were statistically compared across the three grip conditions. The STD of eye movements were greater (p < 0.1) for conventional than cross-hand (9 ft) and one-handed (3 and 9 ft) grips. Also, the STD of head movements were greater (p < 0.1; 3 ft) for conventional than cross-hand and one-handed grips. Vestibulo-ocular responses associated with head rotations could be observed in many 9 ft and some 3 ft putts. The duration of the putt was significantly longer (p < 0.05; 3 and 9 ft) for the one-handed than conventional and cross-hand grips. Finally, performance, or percentage putts made, was significantly

  5. Book Review: Putting People First: African Priorities for the UN ...

    African Journals Online (AJOL)

    Abstract. Book Title: Putting People First: African Priorities for the UN Millennium Assembly (2000). Authors: Pandelani Mathoma, Greg Mills, John Stremlau (eds.) Johannesburg: South African Institute of International Affairs, 129 pp.

  6. The Perpetual American Put Option for Jump-Diffusions

    OpenAIRE

    Aase, Knut K.

    2010-01-01

    -This is the author's version of the article"The Perpetual American Put Option for Jump-Diffusions" Energy Systems pp 493-507. We solve a specific optimal stopping problem with an infinite time horizon, when the state variable follows a jump-diffusion. The novelty of the paper is related to the inclusion of a jump component in this stochastic process. Under certain conditions, our solution can be interpreted as the price of an American perpetual put option. We characterize the continuation...

  7. Regulation of the put Operon in SALMONELLA TYPHIMURIUM: Characterization of Promoter and Operator Mutations

    OpenAIRE

    Hahn, Donald R.; Maloy, Stanley R.

    1986-01-01

    The two genes required for proline utilization by S. typhimurium form a divergent operon. Expression of the put operon is induced by proline and subject to catabolite repression. Genetic evidence suggests that putA protein autogenously represses transcription of the putA and putP genes. In order to establish the molecular mechanism of put operon regulation we isolated regulatory mutations in the put control region. These mutants were selected using two phenotypes: (1) the ability to degrad...

  8. PUTTING COMMUNICATION FRONT AND CENTER IN INSTITUTIONAL THEORY AND ANALYSIS

    NARCIS (Netherlands)

    Cornelissen, J.P.; Durand, R.; Fiss, P.C.; Lammers, J.C.; Vaara, E.

    2015-01-01

    We conceptualize the roots of cognitive, linguistic, and communicative theories of institutions and outline the promise and potential of a stronger communication focus for institutional theory. In particular, we outline a theoretical approach that puts communication at the heart of theories of

  9. Flexible Multilingual Education: Putting Children's Needs First

    Science.gov (United States)

    Weber, Jean-Jacques

    2014-01-01

    This book examines the benefits of multilingual education that puts children's needs and interests above the individual languages involved. It advocates flexible multilingual education, which builds upon children's actual home resources and provides access to both the local and global languages that students need for their educational and…

  10. Putting Disability Studies to Work in Art Education

    Science.gov (United States)

    Penketh, Claire

    2014-01-01

    Putting disability studies to work in art education suggests a form of action or industry, a creative opportunity for something to be done, recognising the relationship between theory and practice. Drawing on discourse analysis, this article offers an initial theoretical discussion of some of the ways in which disability is revealed and created…

  11. Bounds for the American perpetual put on a stock index

    OpenAIRE

    Paulsen, V.

    2001-01-01

    Let us consider n stocks with dependent price processes each following a geometric Brownian motion. We want to investigate the American perpetual put on an index of those stocks. We will provide inner and outer boundaries for its early exercise region by using a decomposition technique for optimal stopping.

  12. The quark gluon plasma: Lattice computations put to experimental test

    Indian Academy of Sciences (India)

    journal of. November 2003 physics pp. 877–888. The quark gluon plasma: Lattice computations put to experimental test. SOURENDU GUPTA. Department of Theoretical Physics, Tata Institute ... lattice gauge theory is the only theoretical tool of direct relevance to experiments currently ... In this talk I will concentrate on other.

  13. Learner Centered Teaching: Putting the Research on Learning into Practice

    Science.gov (United States)

    Doyle, Terry

    2011-01-01

    This book presents the research-based case that Learner Centered Teaching (LCT) offers the best means to optimize student learning in college, and offers examples and ideas for putting it into practice, as well the underlying rationale. It also starts from the premise that many faculty are much closer to being learner centered teachers than they…

  14. "Big Bang"test put off until May 2008

    CERN Multimedia

    2007-01-01

    "First tests in a scientific project aimed at solving mysteries of the universe and the "Big Bang" which created it have been put off from November to late april or early May next year, an official said yesterday." (2/3 page)

  15. Oxygen reactivity of PutA from Helicobacter species and proline-linked oxidative stress.

    Science.gov (United States)

    Krishnan, Navasona; Becker, Donald F

    2006-02-01

    Proline is converted to glutamate in two successive steps by the proline utilization A (PutA) flavoenzyme in gram-negative bacteria. PutA contains a proline dehydrogenase domain that catalyzes the flavin adenine dinucleotide (FAD)-dependent oxidation of proline to delta1-pyrroline-5-carboxylate (P5C) and a P5C dehydrogenase domain that catalyzes the NAD+-dependent oxidation of P5C to glutamate. Here, we characterize PutA from Helicobacter hepaticus (PutA(Hh)) and Helicobacter pylori (PutA(Hp)) to provide new insights into proline metabolism in these gastrointestinal pathogens. Both PutA(Hh) and PutA(Hp) lack DNA binding activity, in contrast to PutA from Escherichia coli (PutA(Ec)), which both regulates and catalyzes proline utilization. PutA(Hh) and PutA(Hp) display catalytic activities similar to that of PutA(Ec) but have higher oxygen reactivity. PutA(Hh) and PutA(Hp) exhibit 100-fold-higher turnover numbers (approximately 30 min(-1)) than PutA(Ec) (PutA(Hh) forms a reversible FAD-sulfite adduct. The significance of increased oxygen reactivity in PutA(Hh) and PutA(Hp) was probed by oxidative stress studies in E. coli. Expression of PutA(Ec) and PutA from Bradyrhizobium japonicum, which exhibit low oxygen reactivity, does not diminish stress survival rates of E. coli cell cultures. In contrast, PutA(Hp) and PutA(Hh) expression dramatically reduces E. coli cell survival and is correlated with relatively lower proline levels and increased hydrogen peroxide formation. The discovery of reduced oxygen species formation by PutA suggests that proline catabolism may influence redox homeostasis in the ecological niches of these Helicobacter species.

  16. Identification and characterization of the DNA-binding domain of the multifunctional PutA flavoenzyme.

    Science.gov (United States)

    Gu, Dan; Zhou, Yuzhen; Kallhoff, Verena; Baban, Berevan; Tanner, John J; Becker, Donald F

    2004-07-23

    The PutA flavoprotein from Escherichia coli is a transcriptional repressor and a bifunctional enzyme that regulates and catalyzes proline oxidation. PutA represses transcription of genes putA and putP by binding to the control DNA region of the put regulon. The objective of this study is to define and characterize the DNA binding domain of PutA. The DNA binding activity of PutA, a 1320 amino acid polypeptide, has been localized to N-terminal residues 1-261. After exploring a potential DNA-binding region and an N-terminal deletion mutant of PutA, residues 1-90 (PutA90) were determined to contain DNA binding activity and stabilize the dimeric structure of PutA. Cell-based transcriptional assays demonstrate that PutA90 functions as a transcriptional repressor in vivo. The dissociation constant of PutA90 with the put control DNA was estimated to be 110 nm, which is slightly higher than that of the PutA-DNA complex (K(d) approximately 45 nm). Primary and secondary structure analysis of PutA90 suggested the presence of a ribbon-helix-helix DNA binding motif in residues 1-47. To test this prediction, we purified and characterized PutA47. PutA47 is shown to purify as an apparent dimer, to exhibit in vivo transcriptional activity, and to bind specifically to the put control DNA. In gel-mobility shift assays, PutA47 was observed to bind cooperatively to the put control DNA with an overall dissociation constant of 15 nm for the PutA47-DNA complex. Thus, N-terminal residues 1-47 are critical for DNA-binding and the dimeric structure of PutA. These results are consistent with the ribbon-helix-helix family of transcription factors.

  17. Redox properties of the PutA protein from Escherichia coli and the influence of the flavin redox state on PutA-DNA interactions.

    Science.gov (United States)

    Becker, D F; Thomas, E A

    2001-04-17

    The PutA flavoprotein from Escherichia coli is both a transcriptional repressor and a membrane-associated proline dehydrogenase. PutA represses transcription of the putA and putP genes by binding to the control region DNA of the put regulon (put intergenic DNA). Previous work has shown that FAD has a role in regulating the transcriptional repressor and membrane binding functions of the PutA protein. To test the influence of the FAD redox state on PutA--DNA interactions, we characterized the redox properties of the PutA flavoprotein from E. coli. At pH 7.5, an E(m)(E--FAD/E--FADH(2)) of --0.076 V for the two-electron reduction of PutA-bound FAD was determined by potentiometric titrations. Stabilization of semiquinone species was not observed during potentiometric measurements. Dithionite reduction of PutA, however, caused formation of red anionic semiquinone. The E(m) value for the proline/Delta(1)-pyrroline-5-carboxylate couple was determined to be --0.123 V, demonstrating the reduction of PutA by proline is favored by a potential difference (Delta E degrees ') of more than 0.045 V. Characterization of the PutA redox properties in the presence of put intergenic DNA revealed an E(m)(E(DNA)--FAD/E(DNA)--FADH(2)) of --0.086 V. The 10 mV negative shift in E(m) corresponds to just a 2.3-fold increase in the dissociation constant of PutA with the DNA upon reduction of FAD. Thus, it appears the FAD redox state has little influence on the overall PutA--DNA interactions.

  18. Fraction in shot-put: A learning trajectory

    Science.gov (United States)

    Putri, R. I. I.; Zulkardi

    2017-08-01

    This research was aimed to produce a learning trajectory that can help students in the fractions learning by using shot-put context at the fourth grade. The method used in this research was research design which has three stages: preparing for the experiment, the design experiment, and the retrospective analysis. Data collection techniques used was interviews, video recordings and photographs, written tests, observation and field notes. This research involved six students who have the high capability, medium capability and low capability at the first cycle and 34 students at the second cycle. The research which was conducted produced learning trajectory that consisted of a series of learning in three mathematics activities. The results showed that by using shot-put context can help students in subtraction of fractions learning and can solve the problems dealing with subtraction of fractions in daily life by using PMRI.

  19. The role of anxiety in golf putting performance

    OpenAIRE

    Kenny, Ian; MacNamara, Aine; Shafat, Amir; Dunphy, Orla; Murphy, Sinead; O'Connor, Kenneth; Ryan, Tara; Waldron, Gerry

    2009-01-01

    peer-reviewed INTRODUCTION: Anxiety???s influence on performance continues to be one of the main research interests for sport psychologists (Hanin, 2000). It is apparent, though, that there is a lack of empirical research characterising the multi-disciplinary effect of anxiety on sports performance. The current study aimed to ascertain biomechanical (accuracy, movement variability) and psychological (anxiety) markers to determine how anxiety affects golf putting. METHOD: 22 healthy s...

  20. Unique Structural Features and Sequence Motifs of Proline Utilization A (PutA)

    OpenAIRE

    Singh, Ranjan K.; Tanner, John J.

    2012-01-01

    Proline utilization A proteins (PutAs) are bifunctional enzymes that catalyze the oxidation of proline to glutamate using spatially separated proline dehydrogenase and pyrroline-5-carboxylate dehydrogenase active sites. Here we use the crystal structure of the minimalist PutA from Bradyrhizobium japonicum (BjPutA) along with sequence analysis to identify unique structural features of PutAs. This analysis shows that PutAs have secondary structural elements and domains not found in the related ...

  1. Application of the Putting Women First protocol in a study on violence against immigrant women in Spain.

    Science.gov (United States)

    Torrubiano-Domínguez, Jordi; Vives-Cases, Carmen

    2013-01-01

    In this paper, we describe our experience of using the Putting Women First protocol in the design and implementation of a cross-sectional study on violence against women (VAW) among 1607 immigrant women from Morocco, Ecuador and Romania living in Spain in 2011. The Putting Women First protocol is an ethical guideline for VAW research, which includes recommendations to ensure the safety of the women involved in studies on this subject. The response rate in this study was 59.3%. The prevalence of VAW cases last year was 11.7%, of which 15.6% corresponded to Ecuadorian women, 10.9% to Moroccan women and 8.6% to Romanian women. We consider that the most important goal for future research is the use of VAW scales validated in different languages, which would help to overcome the language barriers encountered in this study. Copyright © 2012 SESPAS. Published by Elsevier Espana. All rights reserved.

  2. Kinetic and thermodynamic analysis of Bradyrhizobium japonicum PutA-membrane associations.

    Science.gov (United States)

    Zhang, Weimin; Krishnan, Navasona; Becker, Donald F

    2006-01-01

    In Escherichia coli, proline induces tight membrane binding of the PutA flavoenzyme and transforms PutA from a transcriptional repressor to a membrane-associated proline catabolic enzyme. In other gram-negative bacteria such as Bradyrhizobium japonicum, PutA lacks DNA binding activity and functions only as a proline catabolic enzyme. Here, we characterize the membrane binding properties of PutA from B. japonicum (BjPutA) to address whether proline regulates BjPutA-lipid binding similar to Escherichia coli PutA (EcPutA). Surface plasmon resonance (SPR) kinetic measurements of BjPutA-lipid binding show BjPutA forms a complex with lipids in the absence and presence of proline with similar dissociation constant (K(D)) values of 2.5 and 1.7nM, respectively. SPR experiments using differently charged lipid bilayers indicate BjPutA selectively binds negatively charged lipids, which contrasts with the charge independent membrane binding of EcPutA. Analysis of BjPutA-lipid binding by isothermal titration calorimetry at 25 degrees C revealed an endothermic binding reaction that is entropically driven. This work shows that BjPutA-membrane associations vary significantly from EcPutA.

  3. The Human Dimension: Putting the Person into Personalised Medicine.

    Science.gov (United States)

    Horne, Rob

    2017-04-01

    Technological advances enabling us to personalise medical interventions at the biological level must be matched by parallel advances in how we support the informed choices essential to patient and public participation. We cannot take participation for granted. To be truly personalised, medicine must take account of the perceptions and capabilities that shape participation. To do this, we need a better understanding of how people perceive personalised medicine and how they judge its value and risks. To realise the promise of 4P medicine we need to personalise at the psychosocial as well as biological dimension, putting the person into personalised medicine.

  4. Regulation of flavin dehydrogenase compartmentalization: requirements for PutA-membrane association in Salmonella typhimurium.

    Science.gov (United States)

    Surber, M W; Maloy, S

    1999-09-21

    PutA is a multifunctional, peripheral membrane protein which functions both as an autogenous transcriptional repressor and the enzyme which catalyzes the two-step conversion of proline to glutamate in Salmonella typhimurium and Escherichia coli. To understand how PutA associates with the membrane, we determined the role of FAD redox and membrane components in PutA-membrane association. Reduction of the tightly bound FAD is required for both derepression of the put operon and membrane association of PutA. FADH(2) alters the conformation of PutA, resulting in an increased hydrophobicity. Previous studies used enzymatic activity as an assay for membrane association and concluded that electron transfer from the reduced FAD in PutA to the membrane is required for the PutA-membrane interaction. However, direct physical assays of PutA association with membrane vesicles from quinone deficient mutants demonstrated that although electron transfer is essential for proline dehydrogenase activity, it is not required for PutA-membrane association per se. Furthermore, PutA efficiently associated with liposomes, indicating that PutA-membrane association does not require interactions with other membrane proteins. PutA enzymatic activity can be efficiently reconstituted with liposomes containing ubiquinone and cytochrome bo, confirming that proline dehydrogenase can pass electrons directly to the quinone pool. These results indicate that PutA-membrane association is due strictly to a protein-lipid interaction initiated by reduction of FAD.

  5. Put an end to population growth and improve productivity.

    Science.gov (United States)

    Chung, U W

    1999-01-01

    The representative from Korea at the 15th Asian Parliamentarians' Meeting discussed issues concerning the environment, food security, and population growth. The implementation of population control programs is an issue that warrants continuous attention and efforts. The imbalance in the sexes, the decrease in the labor force, the rapid increase in number of senior citizens, insufficient food, unbalanced population distribution due to urbanization, and pollution are some of the new threats humanity faces. Like other developing countries, Korea put environmental protection on the back burner and its economic development took precedence over environmental concerns. As a result, Korea fostered industries that consume massive amounts of energy and resources, polluting the environment. Not only environmental hazards, but also social ills such as population concentration in urban areas, security problems, deteriorating living conditions, and crimes, developed due to industrialization and urbanization. The main priority should be the revival of the earth and the study of the effects of population growth on the environment. The root causes of environmental destruction consist of explosive population growth, industrial pollution, and development; the best way to restrain these destructive forces is to put an end to population growth. To improve food security, humanity needs to make specific action plans to implement the Hague Declaration urging the establishment of the World Food Bank.

  6. Putting Reusability First: A Paradigm Switch in Remote Laboratories Engineering

    Directory of Open Access Journals (Sweden)

    Romain Vérot

    2009-02-01

    Full Text Available In this paper, we present a new devices brought online thanks to our Collaborative Remote Laboratories framework. Whereas previous devices integrated in our remote laboratory belongs to the domain of electronics, such as Vector Network Analyzers, the devices at the concern in this paper are, on one hand, an antenna workbench, and on the other, an homemade switching device, which embeds several electronic components. Because the middleware and framework for our environment were designed to be reusable, we wanted to put it to the test by integrating new and different devices in our Online Engineering catalog. After presenting the devices to be put online, we will expose the software development efforts required in regards to the reusability of the solution. As a consequence, the expose work and results tend to make the Online Engineering software architects to think reusability first, breaking with the current trends to implement Remote Labs one after the other, without much reusability, apart the capitalized experience. In this, we defend a paradigm switch in our current engineering approaches for Remote Laboratories implementations: Reusability should be thought first.

  7. Transfer of mechanical energy during the shot put

    Directory of Open Access Journals (Sweden)

    Błażkiewicz Michalina

    2016-09-01

    Full Text Available The aim of this study was to analyse transfer of mechanical energy between body segments during the glide shot put. A group of eight elite throwers from the Polish National Team was analysed in the study. Motion analysis of each throw was recorded using an optoelectronic Vicon system composed of nine infrared camcorders and Kistler force plates. The power and energy were computed for the phase of final acceleration of the glide shot put. The data were normalized with respect to time using the algorithm of the fifth order spline and their values were interpolated with respect to the percentage of total time, assuming that the time of the final weight acceleration movement was different for each putter. Statistically significant transfer was found in the study group between the following segments: Right Knee – Right Hip (p = 0.0035, Left Hip - Torso (p = 0.0201, Torso – Right Shoulder (p = 0.0122 and Right Elbow – Right Wrist (p = 0.0001. Furthermore, the results of cluster analysis showed that the kinetic chain used during the final shot acceleration movement had two different models. Differences between the groups were revealed mainly in the energy generated by the hips and trunk.

  8. Sinorhizobium meliloti putA gene regulation: a new model within the family Rhizobiaceae.

    Science.gov (United States)

    Soto, M J; Jiménez-Zurdo, J I; van Dillewijn, P; Toro, N

    2000-04-01

    Proline dehydrogenase (PutA) is a bifunctional enzyme that catalyzes the oxidation of proline to glutamate. In Sinorhizobium meliloti, as in other microorganisms, the putA gene is transcriptionally activated in response to proline. In Rhodobacter capsulatus, Agrobacterium, and most probably in Bradyrhizobium, this activation is dependent on an Lrp-like protein encoded by the putR gene, located immediately upstream of putA. Interestingly, sequence and genetic analysis of the region upstream of the S. meliloti putA gene did not reveal such a putR locus or any other encoded transcriptional activator of putA. Furthermore, results obtained with an S. meliloti putA null mutation indicate the absence of any proline-responsive transcriptional activator and that PutA serves as an autogenous repressor. Therefore, the model of S. meliloti putA regulation completely diverges from that of its Rhizobiaceae relatives and resembles more that of enteric bacteria. However, some differences have been found with the latter model: (i) S. meliloti putA gene is not catabolite repressed, and (ii) the gene encoding for the major proline permease (putP) does not form part of an operon with the putA gene.

  9. Medical Education and Curriculum Reform: Putting Reform Proposals in Context

    Directory of Open Access Journals (Sweden)

    Daniel Kam Yin Chan, MD, MB.BS, MHA

    2004-01-01

    Full Text Available The purpose of this paper is to elaborate criteria by which the principles of curriculum reform can be judged. To this end, the paper presents an overview of standard critiques of medical education and examines the ways medical curriculum reforms have responded to these critiques. The paper then sets out our assessment of these curriculum reforms along three parameters: pedagogy, educational context, and knowledge status. Following on from this evaluation of recent curriculum reforms, the paper puts forward four criteria with which to gauge the adequacy medical curriculum reform. These criteria enable us to question the extent to which new curricula incorporate methods and approaches for ensuring that its substance: overcomes the traditional opposition between clinical and resource dimensions of care; emphasizes that the clinical work needs to be systematized in so far as that it feasible; promotes multi-disciplinary team work, and balances clinical autonomy with accountability to non-clinical stakeholders.

  10. Regulation of PutA-membrane associations by flavin adenine dinucleotide reduction.

    Science.gov (United States)

    Zhang, Weimin; Zhou, Yuzhen; Becker, Donald F

    2004-10-19

    Proline utilization A (PutA) from Escherichia coli is a multifunctional flavoprotein that is both a transcriptional repressor of the proline utilization (put) genes and a membrane-associated enzyme which catalyzes the 4-electron oxidation of proline to glutamate. Previously, proline was shown to induce PutA-membrane binding and alter the intracellular location and function of PutA. To distinguish the roles of substrate binding and FAD reduction in the mechanism of how PutA changes from a DNA-binding protein to a membrane-bound enzyme, the kinetic parameters of PutA-membrane binding were measured under different conditions using model lipid bilayers and surface plasmon resonance (SPR). The effects of proline, FAD reduction, and proline analogues on PutA-membrane associations were determined. Oxidized PutA shows no binding to E. coli polar lipid vesicles. In contrast, proline and sodium dithionite induce tight binding of PutA to the lipid bilayer with indistinguishable kinetic parameters and an estimated dissociation constant (K(D)) of PutA-lipid complex. Proline analogues such as L-THFA and DL-P5C also stimulate PutA binding to E. coli polar lipid vesicles with K(D) values ranging from approximately 3.6 to 34 nM (pH 7.4) for the PutA-lipid complex. The greater PutA-membrane binding affinity (>300-fold) generated by FAD reduction relative to the nonreducing ligands demonstrates that FAD reduction controls PutA-membrane associations. On the basis of SPR kinetic analysis with differently charged lipid bilayers, the driving force for PutA-membrane binding is primarily hydrophobic. In the SPR experiments membrane-bound PutA did not bind put control DNA, confirming that the membrane-binding and DNA-binding activities of PutA are mutually exclusive. A model for the regulation of PutA is described in which the overall translocation of PutA from the cytoplasm to the membrane is driven by FAD reduction and the subsequent energy difference ( approximately 24 kJ/mol) between

  11. Launch Velocities in Successful Golf Putting: An Analytical Analysis

    Directory of Open Access Journals (Sweden)

    John F. Mahoney

    2017-04-01

    Full Text Available Background: This study is concerned with the special case of a putted ball intersecting a standard golf hole at its diameter. The velocity of the ball at the initial rim of the hole is termed the launch velocity and depending upon its value the ball may either be captured or it may escape capture by jumping over the hole. The critical value of the launch velocity (V is such that lesser values result in capture while greater values produce escape. Purpose: Since the value of the V entered prominently in some theoretical studies of putting, the aim of the current study is to provide an original re-evaluation of V and to contrast our results with existing results. Method: This analytical analysis relies on trigonometry in conjunction with Newtonian mechanics and the mathematics of projectiles. The results of a recent study into the mathematics of a bouncing ball which included the notions of restitution and friction were also employed in the analysis. Results: If bouncing and slipping do not occur when the ball hits the far rim of the hole our analysis produces a value of V of 1.356 m/s. When bouncing and slipping are present we find that V is at least 1.609 m/s but increases beyond this value as slipping and friction become greater. Useful relations which relate the dynamics and geometry of the ball to V are provided. Conclusion: Since ambient conditions may influence the extent of bounce and slippage we conjecture that the value of V is not unique.

  12. Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA.

    Science.gov (United States)

    Zhou, Yuzhen; Larson, John D; Bottoms, Christopher A; Arturo, Emilia C; Henzl, Michael T; Jenkins, Jermaine L; Nix, Jay C; Becker, Donald F; Tanner, John J

    2008-08-01

    The multifunctional Escherichia coli proline utilization A (PutA) flavoprotein functions both as a membrane-associated proline catabolic enzyme and as a transcriptional repressor of the proline utilization genes putA and putP. To better understand the mechanism of transcriptional regulation by PutA, we have mapped the put-regulatory region, determined a crystal structure of the PutA ribbon-helix-helix domain (PutA52, a polypeptide corresponding to residues 1-52 of E. coli PutA) complexed with DNA, and examined the thermodynamics of DNA binding to PutA52. Five operator sites, each containing the sequence motif 5'-GTTGCA-3', were identified using gel-shift analysis. Three of the sites are shown to be critical for repression of putA, whereas the two other sites are important for repression of putP. The 2.25-A-resolution crystal structure of PutA52 bound to one of the operators (operator 2; 21 bp) shows that the protein contacts a 9-bp fragment corresponding to the GTTGCA consensus motif plus three flanking base pairs. Since the operator sequences differ in flanking bases, the structure implies that PutA may have different affinities for the five operators. This hypothesis was explored using isothermal titration calorimetry. The binding of PutA52 to operator 2 is exothermic, with an enthalpy of -1.8 kcal/mol and a dissociation constant of 210 nM. Substitution of the flanking bases of operator 4 into operator 2 results in an unfavorable enthalpy of 0.2 kcal/mol and a 15-fold-lower affinity, showing that base pairs outside of the consensus motif impact binding. Structural and thermodynamic data suggest that hydrogen bonds between Lys9 and bases adjacent to the GTTGCA motif contribute to transcriptional regulation by fine-tuning the affinity of PutA for put control operators.

  13. Sinorhizobium meliloti putA Gene Regulation: a New Model within the Family Rhizobiaceae

    OpenAIRE

    Soto, María José; Jiménez-Zurdo, José Ignacio; van Dillewijn, Pieter; Toro, Nicolás

    2000-01-01

    Proline dehydrogenase (PutA) is a bifunctional enzyme that catalyzes the oxidation of proline to glutamate. In Sinorhizobium meliloti, as in other microorganisms, the putA gene is transcriptionally activated in response to proline. In Rhodobacter capsulatus, Agrobacterium, and most probably in Bradyrhizobium, this activation is dependent on an Lrp-like protein encoded by the putR gene, located immediately upstream of putA. Interestingly, sequence and genetic analysis of the region upstream of...

  14. PutA Is Required for Virulence and Regulated by PruR in Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Ruiping Zheng

    2018-03-01

    Full Text Available Pseudomonas aeruginosa, a Gram-negative opportunistic pathogenic bacterium, causes acute and chronic infections. Upon entering the host, P. aeruginosa alters global gene expression to adapt to host environment and avoid clearance by the host immune system. Proline utilization A (PutA is a bifunctional enzyme, which converts proline to glutamate. Here we report that PutA was required for the virulence of P. aeruginosa in a murine acute pneumonia model. A putA mutant was more susceptible to oxidative stress compared to the wild type strain. An AraC/XylS family protein, PruR, directly bound to the upstream of −35 box in the putA promoter and activated putA expression. High concentration of proline in bacteria up-regulated pruR expression, which led to the activation of putA expression. As a feedback regulation, glutamate produced by PutA released PruR from the putA promoter and turned off the putA expression. PruR affected bacterial virulence through the regulation of the putA expression. Altogether, these data are the first to reveal that PutA plays an important role in the pathogenesis of P. aeruginosa, as well as to describe the genetic regulation of PutA in P. aeruginosa.

  15. The Effects of Multisensory Imagery in Conjunction with Physical Movement Rehearsal on Golf Putting Performance

    Science.gov (United States)

    Ploszay, A. J.; Gentner, Noah B.; Skinner, Christopher H.; Wrisberg, Craig A.

    2006-01-01

    A multiple-baseline design was used to evaluate the effects of a pre-shot putting routine on the putting performance of four NCAA Division I golfers. The routine involved a combination of multisensory imagery and simulated putting movements. Results suggested that the intervention was effective for some participants. Discussion focuses on…

  16. PutA protein, a membrane-associated flavin dehydrogenase, acts as a redox-dependent transcriptional regulator.

    OpenAIRE

    Ostrovsky de Spicer, P; Maloy, S

    1993-01-01

    The proline utilization (put) operon of Salmonella typhimurium is transcriptionally repressed by PutA protein in the absence of proline. PutA protein also carries out the enzymatic steps in proline catabolism. These two roles require different cellular localizations of PutA. Catabolism of proline requires PutA to associate with the membrane because reoxidation of the FAD cofactor in PutA needs the presence of an electron acceptor. Repression of the put operon requires PutA to bind to the put ...

  17. Effects of proline analog binding on the spectroscopic and redox properties of PutA.

    Science.gov (United States)

    Zhu, Weidong; Gincherman, Yekaterina; Docherty, Paul; Spilling, Christopher D; Becker, Donald F

    2002-12-01

    The PutA flavoprotein regulates proline metabolism in Escherichia coli by performing two distinct functions. First, in the cytoplasm, PutA represses transcription of the put (proline utilization) regulon. Second, PutA associates with the membrane to oxidize proline to glutamate using discrete proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase domains. Here, we identify a proline analog that will be useful for testing the role substrate binding has in regulating PutA functions. L-Tetrahydro-2-furoic acid (L-THFA) was found to display simple competitive inhibition of proline dehydrogenase activity in PutA (apparent K(i)=0.2mM) and to perturb the flavin adenine dinucleotide (FAD) absorbance spectrum upon complexation to PutA. At pH 7.5, a reduction potential (E(m)) of -0.089V for the FAD/FADH(2) couple in L-THFA-complexed PutA was determined by potentiometric titrations. The E(m) value for L-THFA-complexed PutA is 12mV more negative than the E(m) for uncomplexed PutA (E(m)=-0.077V, pH 7.5) and corresponds to just a twofold increase in the dissociation constant of L-THFA with PutA upon reduction of FAD.

  18. Unique structural features and sequence motifs of proline utilization A (PutA).

    Science.gov (United States)

    Singh, Ranjan K; Tanner, John J

    2012-01-01

    Proline utilization A proteins (PutAs) are bifunctional enzymes that catalyze the oxidation of proline to glutamate using spatially separated proline dehydrogenase and pyrroline-5-carboxylate dehydrogenase active sites. Here we use the crystal structure of the minimalist PutA from Bradyrhizobium japonicum (BjPutA) along with sequence analysis to identify unique structural features of PutAs. This analysis shows that PutAs have secondary structural elements and domains not found in the related monofunctional enzymes. Some of these extra features are predicted to be important for substrate channeling in BjPutA. Multiple sequence alignment analysis shows that some PutAs have a 17-residue conserved motif in the C-terminal 20-30 residues of the polypeptide chain. The BjPutA structure shows that this motif helps seal the internal substrate-channeling cavity from the bulk medium. Finally, it is shown that some PutAs have a 100-200 residue domain of unknown function in the C-terminus that is not found in minimalist PutAs. Remote homology detection suggests that this domain is homologous to the oligomerization beta-hairpin and Rossmann fold domain of BjPutA.

  19. Training in virtual environments: putting theory into practice.

    Science.gov (United States)

    Moskaliuk, Johannes; Bertram, Johanna; Cress, Ulrike

    2013-01-01

    Virtual training environments are used when training in reality is challenging because of the high costs, danger, time or effort involved. In this paper we argue for a theory-driven development of such environments, with the aim of connecting theory to practice and ensuring that the training provided fits the needs of the trained persons and their organisations. As an example, we describe the development of VirtualPolice (ViPOL), a training environment for police officers in a federal state of Germany. We provided the theoretical foundation for ViPOL concerning the feeling of being present, social context, learning motivation and perspective-taking. We developed a framework to put theory into practice. To evaluate our framework we interviewed the stakeholders of ViPOL and surveyed current challenges and limitations of virtual training. The results led to a review of a theory-into-practice framework which is presented in the conclusion. Feeling of presence, social context, learning motivation and perspective-taking are relevant for training in virtual environments. The theory-into-practice framework presented here supports developers and trainers in implementing virtual training tools. The framework was validated with an interview study of stakeholders of a virtual training project. We identified limitations, opportunities and challenges.

  20. Putting a price on empathy: against incentivising moral enhancement.

    Science.gov (United States)

    Carter, Sarah

    2015-10-01

    Concerns that people would be disinclined to voluntarily undergo moral enhancement have led to suggestions that an incentivised programme should be introduced to encourage participation. This paper argues that, while such measures do not necessarily result in coercion or undue inducement (issues with which one may typically associate the use of incentives in general), the use of incentives for this purpose may present a taboo trade-off. This is due to empirical research suggesting that those characteristics likely to be affected by moral enhancement are often perceived as fundamental to the self; therefore, any attempt to put a price on such traits would likely be deemed morally unacceptable by those who hold this view. A better approach to address the possible lack of participation may be to instead invest in alternative marketing strategies and remove incentives altogether. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  1. Don’t put your family at risk

    CERN Document Server

    Computer Security Team

    2013-01-01

    How easy is it to fall into the trap of cyber-criminals? Get one’s online banking password stolen? Lose photos to third parties? It's easier than you think. One single click to open a malicious attachment or a malicious web page is sufficient to put your family at risk.   Sometimes adversaries even call you in order to get their malicious job done. Once their malware is installed on your home computer, it records all your activity, monitors your online banking activities, steals your passwords, activates your computer’s microphone and camera, and sends all that data back to the adversary. This person can now do whatever they want: take money from your bank account, order books with your Amazon password, deface your Facebook profiles, send strange messages to your peers, or post the captured images of your daughter in front of the computer on dodgy web sites. Not only can you lose (lots of!) money, but having strange messages sent on your b...

  2. Case studies in control putting theory to work

    CERN Document Server

    Juričić, Đani

    2013-01-01

    Case Studies in Control presents a framework to facilitate the use of advanced control concepts in real systems based on two decades of research and over 150 successful applications for industrial end-users from various backgrounds. In successive parts the text approaches the problem of putting the theory to work from both ends, theoretical and practical. The first part begins with a stress on solid control theory and the shaping of that theory to solve particular instances of practical problems. It emphasizes the need to establish by experiment whether a model-derived solution will perform properly in reality. The second part focuses on real industrial applications based on the needs and requirements of end-users. Here, the engineering approach is dominant but with theoretical input of varying degree depending on the particular process involved. Following the illustrations of the progress that can be made from either extreme of the well-known theory–practice divide, the text proceeds to a third part relate...

  3. Putting flexible animal prospection into context: escaping the theoretical box.

    Science.gov (United States)

    Osvath, Mathias

    2016-01-01

    The debate on non-human future-oriented cognition has long revolved around the question whether such cognition at all occurs. Closer inspection reveals just how much cognition in general-down to its simplest forms-is geared toward predicting the future in a bid to maintain homeostasis and fend off entropy. Over the course of life's existence on Earth, evolution and natural selection have, through a series of evolutionary arms races, gotten increasingly good at achieving this. Prospection has reached its current pinnacle based partly on a system for episodic cognition that-as research increasingly is showing-is not limited principally to human beings. Nevertheless, and despite some notable recent defections, many researchers remain convinced of the merits of the Bischof-Köhler Hypothesis with its claim that no species other than human beings is able to anticipate future needs or otherwise live in anything other than the immediate present moment. What might, at first, appear to be empirical disputes turn out to reveal largely unquestioned theoretical divides. Without due care, one risks setting out conditions for 'true' future orientation that are irrelevant for describing human cognition. In sorting out the theoretical and terminological muddle framing contemporary debate, this article makes a plea for moving beyond past dogmas while putting animal prospection research into the context of evolution and contemporary cognitive science. For further resources related to this article, please visit the WIREs website. © 2015 Wiley Periodicals, Inc.

  4. Households facing constraints. Fuel poverty put into context

    International Nuclear Information System (INIS)

    Dubois, Ute; Meier, Helena

    2014-01-01

    The present paper discusses the concept of fuel poverty taking into account the arbitrages made by households when they are facing economic constraints. Fuel poverty is still lacking a common definition throughout Europe: while the UK and France have (different) official definitions, there is still no definition in a country like Germany, or at the European level. Where definitions exist, they often consider that fuel poor households have high energy needs. The possibility of being fuel poor even without having high energy needs and the various arbitrage possibilities of households - i.e. to under-spend and use too little energy - are not systematically discussed. Our paper tries to fill that gap by putting fuel poverty into the larger context of constraints faced by households. Based on a graphical analysis, it shows that different situations of fuel poverty might occur. It results in the identification of two distinct fuel poverty problems: an ''energy inequality'' problem, reflected by the fact that some households pay disproportionately high energy bills, and an ''energy affordability'' problem that can affect a larger share of the population. It finally explores the two types of fuel poverty for European countries and discusses policy implications.

  5. Households facing constraints. Fuel poverty put into context

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, Ute [ISG Business School, Paris (France); Meier, Helena [Koeln Univ. (Germany). Energiewirtschaftliches Inst.

    2014-02-15

    The present paper discusses the concept of fuel poverty taking into account the arbitrages made by households when they are facing economic constraints. Fuel poverty is still lacking a common definition throughout Europe: while the UK and France have (different) official definitions, there is still no definition in a country like Germany, or at the European level. Where definitions exist, they often consider that fuel poor households have high energy needs. The possibility of being fuel poor even without having high energy needs and the various arbitrage possibilities of households - i.e. to under-spend and use too little energy - are not systematically discussed. Our paper tries to fill that gap by putting fuel poverty into the larger context of constraints faced by households. Based on a graphical analysis, it shows that different situations of fuel poverty might occur. It results in the identification of two distinct fuel poverty problems: an ''energy inequality'' problem, reflected by the fact that some households pay disproportionately high energy bills, and an ''energy affordability'' problem that can affect a larger share of the population. It finally explores the two types of fuel poverty for European countries and discusses policy implications.

  6. Putting science at the heart of European policy

    CERN Multimedia

    2015-01-01

    One year ago, the incoming European Commission President Jean-Claude Juncker shocked the scientific world by scrapping the post of Chief Scientific Advisor. This week, the Commission made amends by launching a well-considered Scientific Advisory Mechanism (SAM) that not only puts science back at the heart of policy, but does so in a much more structured and robust way than conferring such responsibility on a single individual.     The SAM has two independent strands: an advisory group of seven scientists, and funding through the Horizon 2020 programme for national academies and learned societies to network and collaborate on policy issues. Both are backed up by a secretariat at Commission headquarters in Brussels. When Mr Juncker scrapped the role of Chief Scientific Advisor, it was against a backdrop of sometimes vitriolic attacks on the incumbent, Anne Glover, due to her outspoken views on GMOs. Mr Juncker’s move was seen by some as simply giving in to a powerful lob...

  7. Putting your human resource department to work for you.

    Science.gov (United States)

    McConnell, C R

    1991-06-01

    As a staff function, human resources is organized as a service activity. Service activities render no patient care; they do not advance the work of the organization. However, they support the performance of the organization's work and in a practical sense become necessary. For example, if a pure service, such as building maintenance, did not exist, the facility's physical plant would gradually self-destruct. Similarly, without human resources to see to the maintenance of the work force, the overall suitability and capability of that work force will steadily erode. Recognize human resources for what it is--an essential service function required to help the organization run as efficiently as possible. Learn what the HR department does, and especially learn why the department does what it does. Provide input to the human resource department. Forge a continuing working relationship with the HR department, making it clear that you expect service from this essential service department. Challenge the HR department to do more, to do better, and to continually improve service--and put the human resource department to work for you and your employees.

  8. An easy way to put the spleen into the bag.

    Science.gov (United States)

    Cakir, Murat; Tekin, Ahmet; Kartal, Adil; Tuncer, Fatma Betul

    2013-09-01

    Splenectomy is a therapeutic and diagnostic procedure used in a wide range of situations. Laparoscopic splenectomy has become the gold standard in some hematological diseases. The laparoscopically removed spleen is placed into a surgical bag, a step which is sometimes the most time-consuming part of the operation. To present the method that we employed in laparoscopic splenectomy to place the specimen into the bag and extract it in an easier and simpler way. The proximal part of the splenorenal ligament is left undivided in the size of one LigaSure cut length to use as a stalk while placing the spleen into the surgical bag. The bag is advanced from the inferior pole of the spleen toward the superior pole. Only keeping the bag open is sufficient to place the spleen into the bag. Recently, me started to put the spleen into the bag easily before cutting upper attachment of the spleen laparoscopically. So far we applied this procedure in more than eleven cases without complication. Splenectomy is now the gold standard in the treatment of hematologic diseases that are resistant to medical treatment or that are not amenable to medical treatment because of its complications. Through our experience, the method that we describe here easily overcomes one of the most unpleasant parts of laparoscopic splenectomy.

  9. Putting Qumran, Jesus and his movement into relief

    Directory of Open Access Journals (Sweden)

    Eben Scheffler

    2016-11-01

    Full Text Available After referring briefly to the fantasies regarding the origins of Christianity as elicited by the discovery of the Dead Sea Scrolls in 1947 (Dupont-Sommer, Allegro, Thiering, the purpose of the contribution is to put the Jesus movement into relief in the context of first-century Judaism. The identity of the Qumranites is argued to be Essene scribes. The identity, ideology and practices of the latter are compared with those of Jesus of Nazareth and the movement he elicited using the following rubrics: (1 Jesus, the teacher of righteousness and the powers that be; (2 asceticism versus itinerary charismaticism; (3 caring versus lack of caring for the sick, poor and marginalised; (4 elitist priests and scribes versus lower-class peasants; (5 the interpretation of the law; (6 religious and daily practices (baptism, ritual meal, sacrifice, prayer, community of possessions, scribal activity; (7 religious views or ideology (kingdom of God, the new covenant, light and darkness, politics. The result is a picture of Jesus (with his focus on human suffering in sharp relief versus Qumran and facets of the early church.

  10. Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure

    Energy Technology Data Exchange (ETDEWEB)

    Korasick, David A. [Department of Biochemistry, University of Missouri, Columbia MO USA; Singh, Harkewal [Department of Chemistry, University of Missouri, Columbia MO USA; Pemberton, Travis A. [Department of Chemistry, University of Missouri, Columbia MO USA; Luo, Min [Department of Chemistry, University of Missouri, Columbia MO USA; Dhatwalia, Richa [Department of Chemistry, University of Missouri, Columbia MO USA; Tanner, John J. [Department of Biochemistry, University of Missouri, Columbia MO USA; Department of Chemistry, University of Missouri, Columbia MO USA

    2017-08-01

    Many enzymes form homooligomers, yet the functional significance of self-association is seldom obvious. Herein, we examine the connection between oligomerization and catalytic function for proline utilization A (PutA) enzymes. PutAs are bifunctional enzymes that catalyze both reactions of proline catabolism. Type A PutAs are the smallest members of the family, possessing a minimal domain architecture consisting of N-terminal proline dehydrogenase and C-terminal l-glutamate-γ-semialdehyde dehydrogenase modules. Type A PutAs form domain-swapped dimers, and in one case (Bradyrhizobium japonicum PutA), two of the dimers assemble into a ring-shaped tetramer. Whereas the dimer has a clear role in substrate channeling, the functional significance of the tetramer is unknown. To address this question, we performed structural studies of four-type A PutAs from two clades of the PutA tree. The crystal structure of Bdellovibrio bacteriovorus PutA covalently inactivated by N-propargylglycine revealed a fold and substrate-channeling tunnel similar to other PutAs. Small-angle X-ray scattering (SAXS) and analytical ultracentrifugation indicated that Bdellovibrio PutA is dimeric in solution, in contrast to the prediction from crystal packing of a stable tetrameric assembly. SAXS studies of two other type A PutAs from separate clades also suggested that the dimer predominates in solution. To assess whether the tetramer of B. japonicum PutA is necessary for catalytic function, a hot spot disruption mutant that cleanly produces dimeric protein was generated. The dimeric variant exhibited kinetic parameters similar to the wild-type enzyme. These results implicate the domain-swapped dimer as the core structural and functional unit of type A PutAs.

  11. Putting Personal Knowledge Management under the Macroscope of Informing Science

    Directory of Open Access Journals (Sweden)

    Ulrich Schmitt

    2015-08-01

    Full Text Available The paper introduces a novel Personal Knowledge Management (PKM concept and prototype system. The system’s objective is to aid life-long-learning, resourcefulness, creativity, and teamwork of individuals throughout their academic and professional life and as contributors and beneficiaries of organizational and societal performance. Such a scope offers appealing and viable opportunities for stakeholders in the educational, professional, and developmental context. To further validate the underlying PKM application design, the systems thinking techniques of the transdiscipline of Informing Science (IS are employed. By applying Cohen’s IS-Framework, Leavitt’s Diamond Model, the IS-Meta Approach, and Gill’s and Murphy’s Three Dimensions of Design Task Complexity, the more specific KM models and methodologies central to the PKMS concept are aligned, introduced, and visualized. The extent of this introduction offers an essential overview, which can be deepened and broadened by using the cited URL and DOI links pointing to the available resources of the author’s prior publications. The paper emphasizes the differences of the proposed meme-based PKM System compared to its traditional organizational document-centric counterparts as well as its inherent complementing synergies. As a result, it shows how the system is closing in on Vannevar Bush’s still unfulfilled vison of the ‘Memex’, an as-close-as-it-gets imaginary ancestor celebrating its 70th anniversary as an inspiring idea never realized. It also addresses the scenario recently put forward by Levy which foresees a decentralizing revolution of knowledge management that gives more power and autonomy to individuals and self-organized groups. Accordingly, it also touches on the PKM potential in terms of Kuhn’s Scientific Revolutions and Disruptive Innovations.

  12. Intervention Costs From Communities Putting Prevention to Work

    Science.gov (United States)

    Khavjou, Olga A.; Bradley, Christina; Neuwahl, Simon; Hoerger, Thomas J.; Bellard, David; Cash, Amanda J.

    2016-01-01

    Introduction In 2010, the Centers for Disease Control and Prevention funded 50 communities to participate in the Communities Putting Prevention to Work (CPPW) program. CPPW supported community-based approaches to prevent or delay chronic disease and promote wellness by reducing tobacco use and obesity. We collected the direct costs of CPPW for the 44 communities funded through the American Recovery and Reinvestment Act (ARRA) and analyzed costs per person reached for all CPPW interventions and by intervention category. Methods From 2011 through 2013, we collected quarterly data on costs from the 44 CPPW ARRA-funded communities. We estimated CPPW program costs as spending on labor; consultants; materials, travel, and services; overhead activities; and partners plus the value of in-kind donations. We estimated communities’ costs per person reached for each intervention implemented and compared cost allocations across communities that focused on reducing tobacco use, or obesity, or both. Analyses were conducted in 2014; costs are reported in 2012 dollars. Results The largest share of CPPW total costs of $363 million supported interventions in communities that focused on obesity ($228 million). Average costs per person reached were less than $5 for 84% of tobacco-related interventions, 88% of nutrition interventions, and 89% of physical activity interventions. Costs per person reached were highest for social support and services interventions, almost $3 for tobacco‑use interventions and $1 for obesity prevention interventions. Conclusions CPPW cost estimates are useful for comparing intervention cost per person reached with health outcomes and for addressing how community health intervention costs vary by type of intervention and by community size. PMID:27468157

  13. The science of golf putting a complete guide for researchers, players and coaches

    CERN Document Server

    Dias, Gonçalo

    2015-01-01

    This SpringerBrief explores the motor performance and biomechanics of golf putting, providing methodologies, studies and approaches to this concept. Presenting outcomes of research published over the past six years, it offers guidelines from a scientifically oriented perspective, and employs new technologies and mathematical methods to assess golf putting. The chapters cover aspects such as pendulum-like motion in sports, setting up the experimental design, and performance metrics for putting variables. Paving the way for an improved understanding of what leads to failure and success in golf putting, this book offers an invaluable reference source for sports scientists, engineers and mathematicians, as well as golfers.

  14. Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.

    Science.gov (United States)

    Korasick, David A; Singh, Harkewal; Pemberton, Travis A; Luo, Min; Dhatwalia, Richa; Tanner, John J

    2017-09-01

    Many enzymes form homooligomers, yet the functional significance of self-association is seldom obvious. Herein, we examine the connection between oligomerization and catalytic function for proline utilization A (PutA) enzymes. PutAs are bifunctional enzymes that catalyze both reactions of proline catabolism. Type A PutAs are the smallest members of the family, possessing a minimal domain architecture consisting of N-terminal proline dehydrogenase and C-terminal l-glutamate-γ-semialdehyde dehydrogenase modules. Type A PutAs form domain-swapped dimers, and in one case (Bradyrhizobium japonicum PutA), two of the dimers assemble into a ring-shaped tetramer. Whereas the dimer has a clear role in substrate channeling, the functional significance of the tetramer is unknown. To address this question, we performed structural studies of four-type A PutAs from two clades of the PutA tree. The crystal structure of Bdellovibrio bacteriovorus PutA covalently inactivated by N-propargylglycine revealed a fold and substrate-channeling tunnel similar to other PutAs. Small-angle X-ray scattering (SAXS) and analytical ultracentrifugation indicated that Bdellovibrio PutA is dimeric in solution, in contrast to the prediction from crystal packing of a stable tetrameric assembly. SAXS studies of two other type A PutAs from separate clades also suggested that the dimer predominates in solution. To assess whether the tetramer of B. japonicum PutA is necessary for catalytic function, a hot spot disruption mutant that cleanly produces dimeric protein was generated. The dimeric variant exhibited kinetic parameters similar to the wild-type enzyme. These results implicate the domain-swapped dimer as the core structural and functional unit of type A PutAs. Proline dehydrogenase (EC 1.5.5.2); l-glutamate-γ-semialdehyde dehydrogenase (EC 1.2.1.88). The atomic coordinates and structure factor amplitudes have been deposited in the Protein Data Bank under accession number 5UR2. The SAXS data have

  15. Tobacco consumption prevalence and pattern among residents of ...

    African Journals Online (AJOL)

    East African Journal of Public Health ... The prevalence of cigarette smoking was 7.1% and the smokers had smoked for an average of 14.3 ± 5.2 years. ... Stringent policies on smoking including delineation of smoking zone should be put in place to reduce exposure to secondhand smoke and subsequently burdens of ...

  16. Flavin redox state triggers conformational changes in the PutA protein from Escherichia coli.

    Science.gov (United States)

    Zhu, Weidong; Becker, Donald F

    2003-05-13

    The regulation of proline utilization in Escherichia coli involves the proline-dependent translocation of the PutA flavoprotein from the cytoplasm to a peripheral position on the membrane. In the cytoplasm, PutA represses transcription of the proline utilization (put) genes while membrane-bound PutA catalyzes the oxidation of L-proline to glutamate. The mechanism by which PutA switches from a DNA-binding protein to a membrane-bound enzyme involves a proline-induced conformational change that is characterized by the appearance of a 119-kDa fragment during limited proteolysis of proline-reduced PutA. To establish whether the FAD redox state is responsible for the proline-induced conformational change in PutA, we distinguished the effects that FAD reduction and proline analogue binding have on PutA conformation by limited chymotrypsin proteolysis. Controlled potentiometric proteolysis of PutA demonstrated that the formation of the 119-kDa band occurs at an E(m)(conf) value of -0.058 V (pH 7.5), which is within 20 mV of the E(m) value for FAD bound to PutA. The manipulation of the E(m)(conf) value by reconstitution of PutA with the FAD analogue, 5-deazaFAD, confirmed that the conformational change observed in the presence of proline is solely dependent on the FAD redox state. The proline analogue, L-tetrahydro-2-furoic acid (L-THFA), failed to elicit the formation of the 119-kDa fragment during chymotrypsin cleavage of PutA. Instead, a unique fragment of about 93-kDa was observed, indicating that a distinct PutA conformer is stabilized by L-THFA. Reduction of L-THFA-complexed PutA, however, regenerated the 119-kDa fragment showing that reduction of the FAD cofactor overrides conformational changes induced by L-THFA. Mapping of the protease susceptibility sites in PutA revealed that the conformational changes caused by FAD reduction and L-THFA binding are transmitted to domains outside the proline dehydrogenase active site.

  17. Muscular power, neuromuscular activation, and performance in shot put athletes at preseason and at competition period.

    Science.gov (United States)

    Kyriazis, Thomas A; Terzis, Gerasimos; Boudolos, Konstantinos; Georgiadis, Georgios

    2009-09-01

    The aim of this study was to investigate changes in shot put performance, muscular power, and neuromuscular activation of the lower extremities, between the preseason and the competition period, in skilled shot put athletes using the rotational technique. Shot put performance was assessed at the start of the pre-season period as well as after 12 weeks, at the competition period, in nine shot putters. Electromyographic (EMG) activity of the right vastus lateralis muscle was recorded during all shot put trials. Maximum squat strength (1RM) and mechanical parameters during the countermovement jump (CMJ) on a force platform were also determined at pre-season and at competition period. Shot put performance increased 4.7% (p Shot put performance was significantly related with muscular power and takeoff velocity during the CMJ, at competition period (r = 0.66, p shot put performance. These results suggest that muscular power of the lower extremities is a better predictor of rotational shot put performance than absolute muscular strength in skilled athletes, at least during the competition period.

  18. Perpetual American put options in a level-dependent volatility model

    OpenAIRE

    Ekström, Erik

    2003-01-01

    We find the explicit value of perpetual American put options in the constant elasticity of variance model using the concept of smooth fit. We show that the price is increasing in the volatility and convex in the underlying stock price. Moreover, as the model converges to the standard Black and Scholes model, the value of the put is shown to approach the `correct' limit.

  19. Treatment Outcome and Follow‑up of Tuberculosis Patients Put on ...

    African Journals Online (AJOL)

    of this study is to know the treatment outcome, to assess the reasons for relapse, default, death of patient and to assess the follow‑up status of tuberculosis (TB) patients put on directly observed treatment short‑course (DOTS). Subjects and Methods: This cross‑sectional survey was conducted in 140 TB patients put on DOTS ...

  20. A new approach to the study of Gold Putting | Dias | South African ...

    African Journals Online (AJOL)

    The aim of this study was to apply non-linear techniques in the analysis of golf putting performance. How players adapt to the variability that emerges from the putting execution and how they self-organize their performance toward the task constraints was investigated. The sample consisted of 10 adult male golfers ...

  1. 47 CFR 95.408 - (CB Rule 8) How high may I put my antenna?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (CB Rule 8) How high may I put my antenna? 95....408 (CB Rule 8) How high may I put my antenna? (a) Antenna means the radiating system (for... everything else attached to the radiating system and the structure. (b) If your antenna is mounted on a hand...

  2. Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli.

    Science.gov (United States)

    Brown, E D; Wood, J M

    1992-06-25

    Proline utilization by Escherichia coli and Salmonella typhimurium requires expression of genes putP (encoding a proline transporter) and putA. Genetic data indicate that the PutA protein is both put repressor and a respiratory chain-linked dehydrogenase. We report a redesigned purification procedure as well as the physical characteristics and biological activities of the PutA protein purified from E. coli. The purified protein was homogeneous as determined by electrophoresis performed under denaturing and nondenaturing conditions. Its N-terminal sequence corresponded to that predicted by the DNA sequence. We showed copurification of proline and delta 1-pyrroline-5-carboxylate dehydrogenase activities. Purified PutA protein bound put DNA in vitro in an electrophoretic band-shift assay and it could be reconstituted to inverted membrane vesicles, yielding proline dehydrogenase activity. The Stokes radius and Svedberg coefficient of the protein were determined to be 7.1 nm and 9.9 S, respectively. These hydrodynamic data revealed that the protein in our preparation was dimeric with a molecular mass of 293 kDa and that it had an irregular shape indicated by the friction factor (f/f0) of 1.6.

  3. Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA.

    Science.gov (United States)

    Arentson, Benjamin W; Hayes, Erin L; Zhu, Weidong; Singh, Harkewal; Tanner, John J; Becker, Donald F

    2016-12-01

    Proline utilization A (PutA) is a bifunctional flavoenzyme with proline dehydrogenase (PRODH) and Δ 1 -pyrroline-5-carboxylate (P5C) dehydrogenase (P5CDH) domains that catalyses the two-step oxidation of proline to glutamate. Trifunctional PutAs also have an N-terminal ribbon-helix-helix (RHH) DNA-binding domain and moonlight as autogenous transcriptional repressors of the put regulon. A unique property of trifunctional PutA is the ability to switch functions from DNA-bound repressor to membrane-associated enzyme in response to cellular nutritional needs and proline availability. In the present study, we attempt to construct a trifunctional PutA by fusing the RHH domain of Escherichia coli PutA (EcRHH) to the bifunctional Rhodobacter capsulatus PutA (RcPutA) in order to explore the modular design of functional switching in trifunctional PutAs. The EcRHH-RcPutA chimaera retains the catalytic properties of RcPutA while acquiring the oligomeric state, quaternary structure and DNA-binding properties of EcPutA. Furthermore, the EcRHH-RcPutA chimaera exhibits proline-induced lipid association, which is a fundamental characteristic of functional switching. Unexpectedly, RcPutA lipid binding is also activated by proline, which shows for the first time that bifunctional PutAs exhibit a limited form of functional switching. Altogether, these results suggest that the C-terminal domain (CTD), which is conserved by trifunctional PutAs and certain bifunctional PutAs, is essential for functional switching in trifunctional PutAs. © 2016 The Author(s).

  4. Valuing put options on single stock futures: Does the put-call parity relationship hold in the South African derivatives market?

    Directory of Open Access Journals (Sweden)

    A Biebuyck

    2014-12-01

    Full Text Available This study attempts to determine whether mispricing of options on single stock futures is present in the South African derivatives market. The valuation of options on single stock futures is considered through the put-call parity relationship. The theoretical fair values obtained, are compared to the actual market values over a period of three years, that is, from 2009 to 2011. Only put options are considered in this research.The results show that arbitrage put option opportunities do present themselves for the chosen shares. The actual put options were found to be underpriced in 5 out of 6 (83% of the cases considered over the evaluation periods chosen. The mispricing was significant for both the BHP Billiton options with 100% and in the case of Sasol options (66% of the time. Whether profitable arbitrage opportunities is possible, will depend on the magnitude of the mispricing and the transaction fees payable. Further, more extensive research may help identify tendencies which may be of use for the formulation of arbitrage strategies

  5. Putting the social into commodity chains: what motivates smallholders to opt for inclusion?

    NARCIS (Netherlands)

    Clancy, Joy S.; Narayanaswamy, Avinash

    2014-01-01

    The emergence of the concept of sustainable development has put greater emphasis on economic activities that are socially and environmentally responsible. The social dimension of sustainable development reflects increasing interest in integrating poor people into global supply chains. This article

  6. IMPROVING THE STUDENTS’ EFL WRITING ABILITY THROUGH “PUT YOURSELF IN THE PICTURE” STRATEGY

    Directory of Open Access Journals (Sweden)

    Muhammad Lukman Syafii

    2015-09-01

    Full Text Available Abstract: This Action research was intended to improve the students’ EFL writing ability through “Put Yourself in the Picture” strategy. This research involved 33 first year managemen major of students A of Muhammadiyah University of Ponorogo in the academic year 2015/2016. This research was conducted in two cycles by following the procedures of the action research, namely, planning, implementing, observing, and reflecting. Each cycle of the research encompassed three meetings. The data of the research were gathered through observation checklists, field notes, questionnaire, and portfolio. The findings of research showed that “Put Yourself in the Picture” strategy has proven effectively to improve the student’ writing ability. The improvement could be seen from the increase of the students’ average writing score. Besides, “Put Yourself in the Picture” strategy can increase the students’ participation during the process of writing. Key words: “Put Yourself in the Picture” strategy, writing ability

  7. 89 A Review of the Factors Off-Putting the Application of ...

    African Journals Online (AJOL)

    User

    2011-07-21

    Putting the Application of. Relationship Marketing in Nigeria (Pp. 89-103). Ogbuji, Chinedu N. - Department of Marketing, Faculty of Management. Sciences, University of Port Harcourt, Nigeria. E-mail: chiogbuji@yahoo.com.

  8. Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress.

    Science.gov (United States)

    Krishnan, Navasona; Doster, Alan R; Duhamel, Gerald E; Becker, Donald F

    2008-07-01

    Helicobacter hepaticus is a gram-negative, spiral-shaped microaerophilic bacterium associated with chronic intestinal infection leading to hepatitis and colonic and hepatic carcinomas in susceptible strains of mice. In the closely related human pathogen Helicobacter pylori, L-proline is a preferred respiratory substrate and is found at significantly high levels in the gastric juice of infected patients. A previous study of the proline catabolic PutA flavoenzymes from H. pylori and H. hepaticus revealed that Helicobacter PutA generates reactive oxygen species during proline oxidation by transferring electrons from reduced flavin to molecular oxygen. We further explored the preference for proline as a respiratory substrate and the potential impact of proline metabolism on the redox environment in Helicobacter species during host infection by disrupting the putA gene in H. hepaticus. The resulting putA knockout mutant strain was characterized by oxidative stress analysis and mouse infection studies. The putA mutant strain of H. hepaticus exhibited increased proline levels and resistance to oxidative stress relative to that of the wild-type strain, consistent with proline's role as an antioxidant. The significant increase in stress resistance was attributed to higher proline content, as no upregulation of antioxidant genes was observed for the putA mutant strain. The wild-type and putA mutant H. hepaticus strains displayed similar levels of infection in mice, but in mice challenged with the putA mutant strain, significantly reduced inflammation was observed, suggesting a role for proline metabolism in H. hepaticus pathogenicity in vivo.

  9. The perpetual American put option for jump-diffusions with applications

    OpenAIRE

    Aase, Knut K.

    2005-01-01

    In this paper, we solve an optimal stopping problem with an infinite time horizon, when the state variable follows a jump-diffusion. Under certain conditions our solution can be interpreted as the price of an American perpetual put option, when the underlying asset follows this type of process. We present several examples demonstrating when the solution can be interpreted as a perpetual put price. This takes us into a study of how to risk adjust jump-diffusions. One key observatio...

  10. Enhancing the control of force in putting by video game training.

    Science.gov (United States)

    Fery, Y A; Ponserre, S

    2001-10-10

    Even if golf video games provide no proprioceptive afferences on actual putting movement, they may give sufficient substitutive visual cues to enhance force control in this skill. It was hypothesized that this usefulness requires, however, two conditions: the video game must provide reliable demonstrations of actual putts, and the user must want to use the game to make progress in actual putting. Accordingly, a video game was selected on the basis of its fidelity to the real-world game. It allowed two different methods of adjusting the virtual player's putting force in order to hole a putt: an analogue method that consisted of focusing on the virtual player's movement and a symbolic method that consisted of focusing on the movement of a gauge on a scale representing the virtual player's putting force. The participants had to use one of these methods with either the intention of making progress in actual putting or in a second condition to simply enjoy the game. Results showed a positive transfer of video playing to actual putting skill for the learning group and also, to a lesser degree, for the enjoyment group; but only when they used the symbolic method. Results are discussed in the context of how vision may convey force cues in sports video games.

  11. COSMOS (County of San Mateo Online System). A Searcher's Manual.

    Science.gov (United States)

    San Mateo County Superintendent of Schools, Redwood City, CA. Educational Resources Center.

    Operating procedures are explained for COSMOS (County of San Mateo Online System), a computerized information retrieval system designed for the San Mateo Educational Resources Center (SMERC), which provides interactive access to both ERIC and a local file of fugitive documents. COSMOS hardware and modem compatibility requirements are reviewed,…

  12. Physician Information Seeking Behaviors: Are Physicians Successful Searchers?

    Science.gov (United States)

    Swiatek-Kelley, Janice

    2010-01-01

    In the recent past, physicians found answers to questions by consulting colleagues, textbooks, and professional journals. Now, the availability of medical information through electronic resources has changed physician information-seeking behaviors. Evidence-based medicine is now the accepted decision-making paradigm, and a physician's ability to…

  13. Involvement of proline oxidase (PutA in programmed cell death of Xanthomonas.

    Directory of Open Access Journals (Sweden)

    Surbhi Wadhawan

    Full Text Available Xanthomonas campestris strains have been reported to undergo programmed cell death (PCD in a protein rich medium. Protein hydrolysates used in media such as nutrient broth comprise of casein digest with abundance of proline and glutamate. In the current study, X. campestris pv. campestris (Xcc cells displayed PCD when grown in PCD inducing medium (PIM containing casein tryptic digest. This PCD was also observed in PCD non-inducing carbohydrate rich medium (PNIM fortified with either proline or proline along with glutamate. Surprisingly, no PCD was noticed in PNIM fortified with glutamate alone. Differential role of proline or glutamate in inducing PCD in Xcc cells growing in PNIM was studied. It was found that an intermediate product of this oxidation was involved in initiation of PCD. Proline oxidase also called as proline utilization A (PutA, catalyzes the two step oxidation of proline to glutamate. Interestingly, higher PutA activity was noticed in cells growing in PIM, and PCD was found to be inhibited by tetrahydro-2-furoic acid, a competitive inhibitor of this enzyme. Further, PCD was abolished in Xcc ΔputA strain generated using a pKNOCK suicide plasmid, and restored in Xcc ΔputA strain carrying functional PutA in a plasmid vector. Xanthomonas cells growing in PIM also displayed increased generation of ROS, as well as cell filamentation (a probable indication of SOS response. These filamented cells also displayed enhanced caspase-3-like activity during in situ labeling using a fluorescent tagged caspase-3 inhibitor (FITC-DEVD-FMK. The extent of PCD associated markers such as DNA damage, phosphatidylserine externalization and membrane depolarization were found to be significantly enhanced in wild type cells, but drastically reduced in Xcc ΔputA cells. These findings thus establish the role of PutA mediated proline oxidation in regulating death in stressed Xanthomonas cells.

  14. Involvement of proline oxidase (PutA) in programmed cell death of Xanthomonas.

    Science.gov (United States)

    Wadhawan, Surbhi; Gautam, Satyendra; Sharma, Arun

    2014-01-01

    Xanthomonas campestris strains have been reported to undergo programmed cell death (PCD) in a protein rich medium. Protein hydrolysates used in media such as nutrient broth comprise of casein digest with abundance of proline and glutamate. In the current study, X. campestris pv. campestris (Xcc) cells displayed PCD when grown in PCD inducing medium (PIM) containing casein tryptic digest. This PCD was also observed in PCD non-inducing carbohydrate rich medium (PNIM) fortified with either proline or proline along with glutamate. Surprisingly, no PCD was noticed in PNIM fortified with glutamate alone. Differential role of proline or glutamate in inducing PCD in Xcc cells growing in PNIM was studied. It was found that an intermediate product of this oxidation was involved in initiation of PCD. Proline oxidase also called as proline utilization A (PutA), catalyzes the two step oxidation of proline to glutamate. Interestingly, higher PutA activity was noticed in cells growing in PIM, and PCD was found to be inhibited by tetrahydro-2-furoic acid, a competitive inhibitor of this enzyme. Further, PCD was abolished in Xcc ΔputA strain generated using a pKNOCK suicide plasmid, and restored in Xcc ΔputA strain carrying functional PutA in a plasmid vector. Xanthomonas cells growing in PIM also displayed increased generation of ROS, as well as cell filamentation (a probable indication of SOS response). These filamented cells also displayed enhanced caspase-3-like activity during in situ labeling using a fluorescent tagged caspase-3 inhibitor (FITC-DEVD-FMK). The extent of PCD associated markers such as DNA damage, phosphatidylserine externalization and membrane depolarization were found to be significantly enhanced in wild type cells, but drastically reduced in Xcc ΔputA cells. These findings thus establish the role of PutA mediated proline oxidation in regulating death in stressed Xanthomonas cells.

  15. Electrochemical and functional characterization of the proline dehydrogenase domain of the PutA flavoprotein from Escherichia coli.

    Science.gov (United States)

    Vinod, Madhavan P; Bellur, Padmanetra; Becker, Donald F

    2002-05-21

    The multifunctional PutA flavoprotein from Escherichia coli is a peripherally membrane-bound enzyme that has both proline dehydrogenase (PDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) activities. In addition to its enzymatic functions, PutA displays DNA-binding activity and represses proline catabolism by binding to the control region DNA of the put regulon (put intergenic DNA). Presently, information on structure-function relationships for PutA is derived from primary structure analysis. To gain further insight into the functional organization of PutA, our objective is to dissect PutA into different domains and to characterize them separately. Here, we report the characterization of a bifunctional proline dehydrogenase (PutA(669)) that contains residues 1-669 of the PutA protein. PutA(669) purifies as a dimer and has a PDH specific activity that is 4-fold higher than that of PutA. As anticipated, PutA(669) lacks P5CDH activity. At pH 7.5, an E(m) (E-FAD/E-FADH(-)) of -0.091 V for the two-electron reduction of PutA(669)-bound FAD was determined by potentiometric titrations, which is 15 mV more negative than the E(m) for PutA-bound FAD. The pH behavior of the E(m) for PutA(669)-bound FAD was measured in the pH range 6.5-9.0 at 25 degrees C and exhibited a 0.03 V/pH unit slope. Analysis of the DNA and membrane-binding properties of PutA(669) shows that it binds specifically to the put intergenic control DNA with a binding affinity similar to that of PutA. In contrast, we did not observe functional association of PutA(669) with membrane vesicles. We conclude that PutA(669) has FAD-binding and DNA-binding properties comparable to those of PutA but lacks a membrane-binding domain necessary for stable association with the membrane.

  16. Super Searchers on Madison Avenue: Top Advertising and Marketing Professionals Share Their Online Research Strategies. Super Searchers, Volume XI.

    Science.gov (United States)

    Villamora, Grace Avellana

    This book presents interviews with 13 research professionals that contain favorite online search strategies and research tools, anecdotes, "how to" survival tips, and best-practice examples. The appendix lists referenced sites and sources in the following categories: (1) online resources; (2) books, annuals, newsletters, magazines, and…

  17. Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein.

    Science.gov (United States)

    Lee, Yong-Hwan; Nadaraia, Shorena; Gu, Dan; Becker, Donald F; Tanner, John J

    2003-02-01

    The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes. The human homolog of the PutA proline dehydrogenase (PRODH) domain is critical in p53-mediated apoptosis and schizophrenia. Here we report the crystal structure of a 669-residue truncated form of PutA that shows both PRODH and DNA-binding activities, representing the first structure of a PutA protein and a PRODH enzyme from any organism. The structure is a domain-swapped dimer with each subunit comprising three domains: a helical dimerization arm, a 120-residue domain containing a three-helix bundle similar to that in the helix-turn-helix superfamily of DNA-binding proteins and a beta/alpha-barrel PRODH domain with a bound lactate inhibitor. Analysis of the structure provides insight into the mechanism of proline oxidation to pyrroline-5-carboxylate, and functional studies of a mutant protein suggest that the DNA-binding domain is located within the N-terminal 261 residues of E. coli PutA.

  18. Random Versus Blocked Practice to Enhance Mental Representation in Golf Putting.

    Science.gov (United States)

    Fazeli, Davoud; Taheri, HamidReza; Saberi Kakhki, Alireza

    2017-06-01

    The purpose of this study was to investigate changes in mental representation from either random or blocked practice when engaged in golf putting. Thirty participants were randomly assigned to random practice, blocked practice, and no-practice groups. First, we measured novice golfers' initial mental representation levels and required them to perform 18 putting trials as a pre-test. We then asked random and blocked groups to practice in accordance with their group assignment for six consecutive days (10 blocks each day, 18 trials each). A week after the last practice session, we re-measured all participants' final mental representation levels and required them to perform 18 putting trials to evaluate learning retention through practice. While those engaged in the random practice method putted more poorly during acquisition (i.e., practice) than those in blocked practice, the random practice group experienced more accurate retention during the final putting trials, and they showed a more structured mental representation than those in blocked practice, one that was more similar to that of skilled golfers. These results support the acquisition of a rich mental representation through random versus blocked practice.

  19. Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake.

    Science.gov (United States)

    Cheng, Zhihui; Lin, Mingqun; Rikihisa, Yasuko

    2014-11-25

    How the obligatory intracellular bacterium Ehrlichia chaffeensis begins to replicate upon entry into human monocytes is poorly understood. Here, we examined the potential role of amino acids in initiating intracellular replication. PutA converts proline to glutamate, and GlnA converts glutamate to glutamine. E. chaffeensis PutA and GlnA complemented Escherichia coli putA and glnA mutants. Methionine sulfoximine, a glutamine synthetase inhibitor, inhibited E. chaffeensis GlnA activity and E. chaffeensis infection of human cells. Incubation of E. chaffeensis with human cells rapidly induced putA and glnA expression that peaked at 24 h postincubation. E. chaffeensis took up proline and glutamine but not glutamate. Pretreatment of E. chaffeensis with a proline transporter inhibitor (protamine), a glutamine transporter inhibitor (histidine), or proline analogs inhibited E. chaffeensis infection, whereas pretreatment with proline or glutamine enhanced infection and upregulated putA and glnA faster than no treatment or glutamate pretreatment. The temporal response of putA and glnA expression was similar to that of NtrY and NtrX, a two-component system, and electrophoretic mobility shift assays showed specific binding of recombinant E. chaffeensis NtrX (rNtrX) to the promoter regions of E. chaffeensis putA and glnA. Furthermore, rNtrX transactivated E. chaffeensis putA and glnA promoter-lacZ fusions in E. coli. Growth-promoting activities of proline and glutamine were also accompanied by rapid degradation of the DNA-binding protein CtrA. Our results suggest that proline and glutamine uptake regulates putA and glnA expression through NtrY/NtrX and facilitates degradation of CtrA to initiate a new cycle of E. chaffeensis growth. Human monocytic ehrlichiosis (HME) is one of the most prevalent, life-threatening emerging infectious zoonoses in the United States. HME is caused by infection with E. chaffeensis, an obligatory intracellular bacterium in the order

  20. Regulation of proline utilization in Salmonella typhimurium: characterization of put::Mu d(Ap, lac) operon fusions.

    OpenAIRE

    Maloy, S R; Roth, J R

    1983-01-01

    The genes for proline utilization were fused to the structural genes of the lac operon by use of the hybrid Mu phage derivative Mu d(Ap lac). Stable deletion derivatives of these fusions were selected and used to study the transcriptional regulation of the put genes. Analysis of these fusions showed that the putA gene product, a bifunctional oxidase-dehydrogenase, also serves to negatively control transcription of the putA and putP genes. Transcription of the put genes is repressed only in pu...

  1. Putting fossils on the map: Applying a geographical information system to heritage resources

    CSIR Research Space (South Africa)

    Van der Walt, M

    2015-11-01

    Full Text Available http://www.sajs.co.za Volume 111 | Number 11/12 November/December 2015 Research Article Putting fossils on the map Page 1 of 7 © 2015. The Author(s). Published under a Creative Commons Attribution Licence. Putting fossils on the map: Applying a..., as the majority of records had only a farm name for the locality, a spatial database had to be created to allow records to be imported automatically to specific localities referenced as farm centroids. A farm centroid is the calculated gravitational centre...

  2. The putA gene of Agrobacterium tumefaciens is transcriptionally activated in response to proline by an Lrp-like protein and is not autoregulated.

    Science.gov (United States)

    Cho, K; Winans, S C

    1996-12-01

    The Agrobacterium tumefaciens putA gene, which encodes proline dehydrogenase, is transcriptionally induced by exogenous proline. In contrast to the putA genes of enteric bacteria, the A. tumefaciens putA gene is not regulated by the PutA protein, as the putA promoter remained strongly proline inducible in strains lacking PutA. A putA null mutation increased the expression of the putA promoter under a variety of conditions. However, this mutation is predicted to increase the cytoplasmic concentration of proline, and this alone probably accounts for its effects on putA expression. The putA promoter was also strongly induced by valine, and the putA genotype did not affect expression by this gratuitous inducer. An open reading frame (ORF) encoding an Lrp-like protein was found transcribed divergently from putA. Disruption of this ORF, designated putR, abolished induction of the putA promoter by proline or valine. In addition to activating putA, PutR also repressed its own transcription, and this autorepression was only slightly affected by exogenous proline. The transcription start sites for the putA and putR genes are separated by 64 nucleotides, suggesting that PutR could regulate both promoters by binding to a single operator.

  3. Strongyloides spp Distribution on Orangutans in Tanjung Putting National Park, Care Center in Pangkalanbun, and Sebangau National Park

    Directory of Open Access Journals (Sweden)

    Wisnu Nurcahyo

    2013-09-01

    Full Text Available Strongyloides spp is a parasitic nematode in livestock, primate and human which is  considered asa danger zoonotic disease. Therefore, study about parasite distribution is very important in order to find outgenetic diversity among orangutan in quarantine, zoo and nature, as an effort to explore infection patternand life cycle of Strongyloides spp on orangutan. Amount of 326 orangutan feces were taken from threedifferent habitat of orangutan in Central Borneo, Tanjung Puting National Park, Orangutan Care Centerand Sebangau National Park. Samples which were collected from Tanjung Puting, Care Center and Sebangauwere 75, 80 and 171 respectively. Those samples were transported to the Parasitology laboratory in Facultyof Veterinary Medicine, Gadjah Mada University, Yogyakarta for examination and detection.  Prevalence ofstrongyloides in Tanjung Putting, Sebangau and Orangutan Care Center were 24%, 14,6% and 13,3%respectively. Among positive samples of Strongyloides, 62,5% were from male orangutans, while 37,5% werefrom female orangutans. Strongyloides in pre adult and baby orangutan were 91,6% and 4,2% respectively.Meanwhile, Strongyloides in adult orangutan were very rare. Orangutan habitat in Sebangau National Parkis an ideal habitat for orangutan, supported by the watery condition of peat land, so that Strongyloides re-infection become difficult. Some factors may have important role in Strongyloidoses, such as behavior,physical condition, nutrition, age, body weight, sex, immunity and social status of orangutan.

  4. Putting the Learning in Service Learning: From Soup Kitchen Models to the Black Metropolis Model

    Science.gov (United States)

    Manley, Theodoric, Jr.; Buffa, Avery S.; Dube, Caleb; Reed, Lauren

    2006-01-01

    Results of the Black Metropolis Model (BMM) of service learning are analyzed and illustrated in this article to explain how to "put the learning in service learning." There are many soup kitchens or nontransforming models of service learning where students are asked to serve needy populations but internalize and learn little about the…

  5. Putting crime in its place : Units of analysis in geographic criminology

    NARCIS (Netherlands)

    Weisburd, David; Bernasco, Wim; Bruinsma, Gerben J N

    2009-01-01

    Putting Crime in its Place: Units of Analysis in Geographic Criminology focuses on the units of analysis used in geographic criminology. While crime and place studies have been a part of criminology from the early 19th century, growing interest in crime places over the last two decades demands

  6. On the Perpetual American Put Options for Level Dependent Volatility Models with Jumps

    OpenAIRE

    Bayraktar, Erhan

    2007-01-01

    We prove that the perpetual American put option price of level dependent volatility model with compound Poisson jumps is convex and is the classical solution of its associated quasi-variational inequality, that it is $C^2$ except at the stopping boundary and that it is $C^1$ everywhere (i.e. the smooth pasting condition always holds).

  7. A note on the pricing of the perpetual American capped power put option

    OpenAIRE

    Sakagami, Yoshitaka

    2012-01-01

    We give an explicit solution to the perpetual American capped power put option pricing problem in the Black-Scholes-Merton Model. The approach is mainly based on free-boundary formulation and verification. For completeness we also give an explicit solution to the perpetual American standard power (≥1) option pricing problem.

  8. Central American refugees: protected or put at risk by communication technologies?

    Directory of Open Access Journals (Sweden)

    Guillermo Barros

    2017-10-01

    Full Text Available In a world that is more interconnected than ever, many refugees cannot obtain information or communicate when they most need to. Paradoxically, carrying a phone or connecting to the internet can put them at risk if they do not take security measures.

  9. The Effects of Increased Body Temperature on Motor Control during Golf Putting.

    Science.gov (United States)

    Mathers, John F; Grealy, Madeleine A

    2016-01-01

    This study investigated the effect of increased core temperature on the performance outcome and movement kinematics of elite golfers during a golf putting task. The study aimed to examine individual differences in the extent to which increased temperature influenced the rate of putting success, whether increased temperature speeded up the timing of the putting downswing and whether elite golfers changed their movement kinematics during times of thermal stress. Six participants performed 20 putts to each of four putt distances (1, 2, 3, and 4 m) under normal temperature conditions and when core body temperature was increased. There was no significant difference in the number of successful putts between the two temperature conditions, but there was an increase in putterhead velocity at ball impact on successful putts to distances of 1 and 4 m when temperature was elevated. This reflected an increase in swing amplitude rather than a reduction in swing duration as hypothesized. There were individual differences in the motor control response to thermal stress as three of the golfers changed the kinematic parameters used to scale their putting movements to achieve putts of different distances at elevated temperatures. Theoretical implications for these findings and the practical implications for elite golfers and future research are discussed.

  10. Flipping the Educational System: Putting Teachers at the Heart of Teaching

    Science.gov (United States)

    Kneyber, René

    2014-01-01

    This article describes an initiative led by two classroom teachers from the Netherlands to put teachers back at the centre of the educational process. The article argues that the educational system has become inverted, with those who are most influential (teachers) having the least opportunity to influence. The challenge is to "flip the…

  11. Three crystal forms of the bifunctional enzyme proline utilization A (PutA) from Bradyrhizobium japonicum

    International Nuclear Information System (INIS)

    Schuermann, Jonathan P.; White, Tommi A.; Srivastava, Dhiraj; Karr, Dale B.; Tanner, John J.

    2008-01-01

    The first diffraction-quality crystals of a PutA protein are reported. One of the three crystal forms described here exhibits pseudo-merohedral twinning. Removal of the N-terminal histidine tag aided the crystallization of another form. Proline utilization A proteins (PutAs) are large (1000–1300 residues) membrane-associated bifunctional flavoenzymes that catalyze the two-step oxidation of proline to glutamate by the sequential action of proline dehydrogenase and Δ 1 -pyrroline-5-carboxylate dehydrogenase domains. Here, the first successful crystallization efforts for a PutA protein are described. Three crystal forms of PutA from Bradyrhizobium japonicum are reported: apparent tetragonal, hexagonal and centered monoclinic. The apparent tetragonal and hexagonal crystals were grown in the presence of PEG 3350 and sodium formate near pH 7. The apparent tetragonal form diffracted to 2.7 Å resolution and exhibited pseudo-merohedral twinning such that the true space group is P2 1 2 1 2 1 with four molecules in the asymmetric unit. The hexagonal form diffracted to 2.3 Å resolution and belonged to space group P6 2 22 with one molecule in the asymmetric unit. Centered monoclinic crystals were grown in ammonium sulfate, diffracted to 2.3 Å resolution and had two molecules in the asymmetric unit. Removing the histidine tag was important in order to obtain the C2 crystal form

  12. Structure, function, and mechanism of proline utilization A (PutA).

    Science.gov (United States)

    Liu, Li-Kai; Becker, Donald F; Tanner, John J

    2017-10-15

    Proline has important roles in multiple biological processes such as cellular bioenergetics, cell growth, oxidative and osmotic stress response, protein folding and stability, and redox signaling. The proline catabolic pathway, which forms glutamate, enables organisms to utilize proline as a carbon, nitrogen, and energy source. FAD-dependent proline dehydrogenase (PRODH) and NAD + -dependent glutamate semialdehyde dehydrogenase (GSALDH) convert proline to glutamate in two sequential oxidative steps. Depletion of PRODH and GSALDH in humans leads to hyperprolinemia, which is associated with mental disorders such as schizophrenia. Also, some pathogens require proline catabolism for virulence. A unique aspect of proline catabolism is the multifunctional proline utilization A (PutA) enzyme found in Gram-negative bacteria. PutA is a large (>1000 residues) bifunctional enzyme that combines PRODH and GSALDH activities into one polypeptide chain. In addition, some PutAs function as a DNA-binding transcriptional repressor of proline utilization genes. This review describes several attributes of PutA that make it a remarkable flavoenzyme: (1) diversity of oligomeric state and quaternary structure; (2) substrate channeling and enzyme hysteresis; (3) DNA-binding activity and transcriptional repressor function; and (4) flavin redox dependent changes in subcellular location and function in response to proline (functional switching). Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Unwanted effects in aiming actions: The relationship between gaze behavior and performance in golf putting task

    NARCIS (Netherlands)

    Binsch, O.; Oudejans, R.R.D.; Bakker, F.C.; Savelsbergh, G.J.P.

    2009-01-01

    Objectives: Instructions to avoid an action may increase the tendency to engage in the action (ironic effects) or cause an undesirable increase in the opposing action (overcompensation). The aim of the study was to examine the relationship between gaze behavior and performance in a golf putting task

  14. Lurking on the Internet: A Small-Group Assignment that Puts a Human Face on Psychopathology

    Science.gov (United States)

    Lowman, Joseph; Judge, Abigail M.; Wiss, Charles

    2010-01-01

    Lurking on the Internet aims to put a human face on psychopathology for the abnormal psychology course. Student groups are assigned major diagnostic categories and instructed to search the Internet for discussion forums, individual blogs, or YouTube videos where affected individuals discuss their symptoms and lives. After discussing the ethics of…

  15. Teach Like a Champion: 49 Techniques that Put Students on the Path to College

    Science.gov (United States)

    Lemov, Doug

    2010-01-01

    "Teach Like a Champion" offers effective teaching techniques to help teachers, especially those in their first few years, become champions in the classroom. These powerful techniques are concrete, specific, and are easy to put into action the very next day. Training activities at the end of each chapter help the reader further their…

  16. Access to data and material for research: Putting empirical evidence into perspective

    NARCIS (Netherlands)

    Rodriguez, V.

    2009-01-01

    The aim of this article is to put into critical perspective the empirical findings on secrecy and withholding in research. In other words, by taking existing empirical literature into account, it is intended that a crucial question is answered: Is secrecy and withholding in research harmful or

  17. Epilogue: The Contemporary Crucible: Putting Scientific Evidence to the Test in the Context of Schools.

    Science.gov (United States)

    Crockett, Jean B.

    2001-01-01

    The concluding article to this special issue asks what science and its empirical rigors mean to those who work with children and youths with emotional or behavioral disorders. It considers how scientific evidence is being put to the test in the current context of schools and what failure to rely on empirical data might cost in the long run.…

  18. Regularity of the exercise boundary for American put options on assets with discrete dividends

    NARCIS (Netherlands)

    Jourdain, B.; Vellekoop, M.

    2009-01-01

    We analyze the regularity of the optimal exercise boundary for the American Put option when the underlying asset pays a discrete dividend at a known time td during the lifetime of the option. The ex-dividend asset price process is assumed to follow Black-Scholes dynamics and the dividend amount is a

  19. Performance and Kinematic Differences in Putting Between Healthy and Disabled Elite Golfers

    Directory of Open Access Journals (Sweden)

    Gryc Tomáš

    2017-12-01

    Full Text Available Golfers with disability are limited in the execution of the full golf swing, but their performance in putting may be comparable because this stroke does not demand significant strength, balance and range of motion. Therefore, the aim of this study was to compare putting performance, kinetic and kinematic consistency between golfers with different disabilities and healthy athletes. The participants consisted of three disabled athletes (perinatal cerebral palsy, multiple sclerosis, below knee lower limb amputee and three healthy golfers (age 34 ± 4.5 years, body height 178 ± 3.3 cm, body mass 83 ± 6.2 kg. The golfers’ movements were recorded by active 3D markers for kinematic analyses; the subjects performed 10 trials of a 6 m putting task while standing on separate force platforms placed under each lower limb. Putting performance was measured by the distance of the final ball position to the centre of the hole. ANOVA analyses did not show any differences in clubhead speed and total ball distance from the hole. The consistency of those two parameters expressed by the coefficient of variation (CV was CV = 0.5% or better in both groups for clubhead speed and ranged from CV = 0.40 to 0.61% in healthy and CV = 0.21 to 0.55% in disabled athletes for total error distance. The main effect ANOVA showed differences in weight shift, hip and shoulder kinematics (p < 0.05 between healthy players and all players with disability. All disabled athletes shifted their weight toward the healthy side (towards the healthy lower limb and alternated the end of the swing. The player with below knee amputation had the lowest range of motion in the shoulder joint during the putting stroke. The players with perinatal cerebral palsy and multiple sclerosis had the largest range of motion in the hips. Putting performance of disabled golfers was similar to healthy athletes. During training of disabled players, coaches should pay attention to the specificity of a

  20. Crystallization and preliminary crystallographic analysis of the proline dehydrogenase domain of the multifunctional PutA flavoprotein from Escherichia coli.

    Science.gov (United States)

    Nadaraia, S; Lee, Y H; Becker, D F; Tanner, J J

    2001-12-01

    The PutA flavoprotein from Escherichia coli is a multifunctional protein that plays pivotal roles in proline catabolism by functioning as both a membrane-associated bifunctional enzyme and a transcriptional repressor. Peripherally membrane-bound PutA catalyzes the two-step oxidation of proline to glutamate, while cytoplasmic PutA represses the transcription of its own gene and the gene for a proline-transporter protein. X-ray crystallographic studies on PutA have been initiated to determine how the PutA structural scaffold enables it to be both an enzyme and a repressor, and to understand the mechanism by which PutA switches between its enzymatic and DNA-binding functions. To facilitate crystallization, a recombinant protein (PutA669) corresponding to the N-terminal 669 amino-acid residues of the 1320 residues of PutA was engineered. Activity assays demonstrated that PutA669 catalyzes the first step of chemistry performed by PutA, the conversion of proline to Delta1-pyrroline-5-carboxylate. Crystals of PutA669 have been obtained from PEG 3000 buffered at pH 6-7. The crystals occupy an I-centered orthorhombic lattice with unit-cell parameters a = 72.5, b = 140.2, c = 146.8 A; a 2.15 A data set was collected using a rotating-anode source. Assuming one molecule per asymmetric unit, the Matthews coefficient V(M) is 2.5 A(3) Da(-1), with a solvent content of 50%. The structure of PutA669 will be solved by multiple isomorphous replacement.

  1. Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA

    OpenAIRE

    Arentson, Benjamin?W.; Hayes, Erin?L.; Zhu, Weidong; Singh, Harkewal; Tanner, John?J.; Becker, Donald?F.

    2016-01-01

    Proline utilization A (PutA) is a bifunctional flavoenzyme with proline dehydrogenase (PRODH) and ?1-pyrroline-5-carboxylate (P5C) dehydrogenase (P5CDH) domains that catalyses the two-step oxidation of proline to glutamate. Trifunctional PutAs also have an N-terminal ribbon?helix?helix (RHH) DNA-binding domain and moonlight as autogenous transcriptional repressors of the put regulon. A unique property of trifunctional PutA is the ability to switch functions from DNA-bound repressor to membran...

  2. Organizations putting in place in case of accident in a french nuclear power plant

    International Nuclear Information System (INIS)

    Noc, B.; Queniart, D.

    1987-01-01

    In case of accident entraining radiological consequences on or near the site of nuclear power reactor, organizations are putting in place. These organizations include as well as side of operating authority (generally Electricite de France) or public organizations including safety organizations (Service Central de Surete des Installations Nucleaires, Institut de Protection et de Surete Nucleaire), one local organization and one centralized national organization. Informations exchange and coordination necessary between these organizations are governed by protocols. These protocols include particularly, the problems of mobilizing experts and of dealing with the saturation of normal telecommunications channels. The lessons acquired during accident simulation exercises carried out in recent years are progressively put in place in these protocols [fr

  3. Putting a spin on circulating reference, or how to rediscover the scientific subject.

    Science.gov (United States)

    Kochan, Jeff

    2015-02-01

    Bruno Latour claims to have shown that a Kantian model of knowledge, which he describes as seeking to unite a disembodied transcendental subject with an inaccessible thing-in-itself, is dramatically falsified by empirical studies of science in action. Instead, Latour puts central emphasis on scientific practice, and replaces this Kantian model with a model of "circulating reference." Unfortunately, Latour's alternative schematic leaves out the scientific subject. I repair this oversight through a simple mechanical procedure. By putting a slight spin on Latour's diagrammatic representation of his theory, I discover a new space for a post-Kantian scientific subject, a subject brilliantly described by Ludwik Fleck. The neglected subjectivities and ceaseless practices of science are thus re-united. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. The PutA protein of Salmonella typhimurium catalyzes the two steps of proline degradation via a leaky channel.

    Science.gov (United States)

    Surber, M W; Maloy, S

    1998-06-15

    Proline utilization in Salmonella typhimurium requires two proteins encoded by the put operon: PutP, the major proline permease, and PutA. PutA is a multifunctional, peripheral membrane protein which acts both as a transcriptional repressor for the put operon and enzyme catalyzing the two-step conversion of proline to glutamate. In the first enzymatic reaction catalyzed by PutA, proline oxidation to pyrroline-5-carboxylate (P5C) is coupled with the reduction of a tightly associated FAD. In the second reaction, P5C oxidation to glutamate is coupled with reduction of soluble NAD. Although PutA can use exogenous P5C, the concentration of exogenous P5C required for the P5C dehydrogenase reaction is much greater than the steady-state P5C concentration accumulated during proline degradation. Furthermore, exogenous P5C does not efficiently compete against endogenous P5C for the production of glutamate, and the endogenous P5C produced directly from proline is preferentially used by PutA for the production of glutamate. Kinetic assays indicate that in the presence of NAD the two enzymatic reactions of PutA function synchronously to increase the overall reaction rate over that of the two independent reactions, and the second reaction proceeds in the absence of a lag phase. These results indicate that PutA directly transfers the intermediate P5C between the two enzymatic functions via a "leaky channel" mechanism. Because both the reduction of FAD and the intermediate P5C stimulate membrane association of PutA, channeling of P5C may also contribute to the regulation of proline utilization. Copyright 1998 Academic Press.

  5. Worldwide prevalence of hypospadias.

    Science.gov (United States)

    Springer, A; van den Heijkant, M; Baumann, S

    2016-06-01

    Hypospadias is a common congenital malformation. Surgical repair and management of the long-term consequences require a substantial amount of socioeconomic resources. It is generally accepted that genetic and environmental factors play a major role in the etiology of hypospadias. There have been contradictory reports on rising hypospadias rates, and regional and ethnical differences. The exact prevalence of hypospadias is of major interest for healthcare providers, clinical medicine, and research. To review the literature regarding the worldwide prevalence of hypospadias. Pubmed, EMBASE and Google were systematically screened for: hypospadias, congenital malformation, anomaly, incidence, prevalence, and epidemiology. Exclusion criteria were surgical and risk-factor studies. To give an additional comprehensive overview, prevalence data were harvested from the Annual Report of the International Clearinghouse Centre for Birth Defects Surveillance and Research. Prevalence was reported as per 10,000 live births. Data were available from 1910 to 2013. The median study period was 9 years (range: 1-36 years). Approximately 90,255,200 births have been screened in all studies. The mean prevalence were: Europe 19.9 (range: 1-464), North America 34.2 (6-129.8), South America 5.2 (2.8-110), Asia 0.6-69, Africa 5.9 (1.9-110), and Australia 17.1-34.8. There were major geographical, regional, and ethnical differences, with an extreme heterogeneity of published studies. Numerous studies showed an increasing prevalence; on the other hand, there were a lot of contradictory data on the prevalence of hypospadias. The summary table shows contradictory data from the five largest international studies available. There was huge literature available on the prevalence of hypospadias. Most data derived from Europe and North America. Many methodological factors influenced the calculation of an accurate prevalence, and even more of the true changes in prevalence over time (no generally accepted

  6. Renewable Resources – a Way of Putting an End to Environmental Pollution and an Inexhaustible Asset

    OpenAIRE

    Cristina Bumbac

    2009-01-01

    Being “green” is not anymore just a problem of trendy or only for people with special ideas. “Green” became a global issue, involving governments, international organisations, regional authorities. Renewable resources are becoming more and more important, especially in countries where the dependence of imported fuels is high. The climate change put a huge pressure on carbon emmissions and endorsed programmes which take into consideration alternative resources. The European Union is the mo...

  7. Effects of physical randomness training on virtual and laboratory golf putting performance in novices.

    Science.gov (United States)

    Pataky, T C; Lamb, P F

    2017-10-09

    External randomness exists in all sports but is perhaps most obvious in golf putting where robotic putters sink only 80% of 5 m putts due to unpredictable ball-green dynamics. The purpose of this study was to test whether physical randomness training can improve putting performance in novices. A virtual random-physics golf-putting game was developed based on controlled ball-roll data. Thirty-two subjects were assigned a unique randomness gain (RG) ranging from 0.1 to 2.0-times real-world randomness. Putter face kinematics were measured in 5 m laboratory putts before and after five days of virtual training. Performance was quantified using putt success rate and "miss-adjustment correlation" (MAC), the correlation between left-right miss magnitude and subsequent right-left kinematic adjustments. Results showed no RG-success correlation (r = -0.066, p = 0.719) but mildly stronger correlations with MAC for face angle (r = -0.168, p = 0.358) and clubhead path (r = -0.302, p = 0.093). The strongest RG-MAC correlation was observed during virtual training (r = -0.692, p physical randomness in virtual training, and also that this learning may weakly transfer to real golf putting kinematics. Adaptation to external physical randomness during virtual training may therefore help golfers adapt to external randomness in real-world environments.

  8. Photo-mediated ultrasound therapy (PUT): a novel method of selectively treating neovascularization (Conference Presentation)

    Science.gov (United States)

    Zhang, Haonan; Hu, Zi Zhong; Li, Jia; Mordovanakis, Aghapi G.; Yang, Xinmai; Paulus, Yannis M.; Wang, Xueding

    2017-02-01

    Retinal and choroidal neovascularization play a pivotal role in the leading causes of blindness including macular degeneration and diabetic retinopathy (DR). Current therapy by focal laser photocoagulation can damage the normal surrounding cells, such as the photoreceptor inner and outer segments which are adjacent to the retinal pigment epithelium (RPE), due to the use of high laser energy and millisecond pulse duration. Therapies with pharmaceutical agents involve systemic administration of drugs, which can cause adverse effects and patients may become drug-resistant. We have developed a noninvasive photo-mediated ultrasound therapy (PUT) technique as a localized antivascular method, and applied it to remove micro blood vessels in the retina. PUT takes advantage of the high native optical contrast among biological tissues, and has the unique capability to self-target microvessels without causing unwanted damages to the surrounding tissues. This technique promotes cavitation activity in blood vessels by synergistically applying nanosecond laser pulses and ultrasound bursts. Through the interaction between cavitation and blood vessel wall, blood clots in microvessels and vasoconstriction can be induced. As a result, microvessels can be occluded. In comparison with other techniques that involves cavitation, both laser and ultrasound energy needed in PUT is significantly lower, and hence improves the safety in therapy.

  9. Condom use errors and problems among young women who put condoms on their male partners.

    Science.gov (United States)

    Sanders, Stephanie A; Graham, Cynthia A; Yarber, William L; Crosby, Richard A

    2003-01-01

    To comprehensively assess condom use errors and problems reported by women who apply condoms, given the lack of data on this aspect of condom use. Data from a questionnaire survey, using a 3-month recall period, was analyzed for a convenience sample of 102 college women who put condoms on their male partner(s) for sex (vaginal, anal, or oral). The percentage of the sample reporting that an error or problem occurred at least once is presented. Fifty-one percent put the condom on after starting sex, and 15% took the condom off before ending sex. Forty-eight percent wanted a condom but didn't have one, 46% did not leave space at the tip, 30% put the condom on wrong side up and had to flip the condom over, 26% did not use a lubricant, and 15% wanted a water-based lubricant and did not have any available. Twenty-five percent reported that their partners lost erections in association with condom use. Twenty-eight percent reported breakage, slippage, or both. Higher error scores were found for those who reported: 1) breakage or slippage, 2) partner erection problems, 3) use of another form of contraception, and 4) not having received instruction in correct condom use. Educating women as well as men about correct condom use, in addition to promoting consistent condom use, may be an important public health strategy.

  10. The Posture of Putting One's Palms Together Modulates Visual Motion Event Perception.

    Science.gov (United States)

    Saito, Godai; Gyoba, Jiro

    2018-02-01

    We investigated the effect of an observer's hand postures on visual motion perception using the stream/bounce display. When two identical visual objects move across collinear horizontal trajectories toward each other in a two-dimensional display, observers perceive them as either streaming or bouncing. In our previous study, we found that when observers put their palms together just below the coincidence point of the two objects, the percentage of bouncing responses increased, mainly depending on the proprioceptive information from their own hands. However, it remains unclear if the tactile or haptic (force) information produced by the postures mostly influences the stream/bounce perception. We solved this problem by changing the tactile and haptic information on the palms of the hands. Experiment 1 showed that the promotion of bouncing perception was observed only when the posture of directly putting one's palms together was used, while there was no effect when a brick was sandwiched between the participant's palms. Experiment 2 demonstrated that the strength of force used when putting the palms together had no effect on increasing bounce perception. Our findings indicate that the hands-induced bounce effect derives from the tactile information produced by the direct contact between both palms.

  11. Three crystal forms of the bifunctional enzyme proline utilization A (PutA) from Bradyrhizobium japonicum.

    Science.gov (United States)

    Schuermann, Jonathan P; White, Tommi A; Srivastava, Dhiraj; Karr, Dale B; Tanner, John J

    2008-10-01

    Proline utilization A proteins (PutAs) are large (1000-1300 residues) membrane-associated bifunctional flavoenzymes that catalyze the two-step oxidation of proline to glutamate by the sequential action of proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase domains. Here, the first successful crystallization efforts for a PutA protein are described. Three crystal forms of PutA from Bradyrhizobium japonicum are reported: apparent tetragonal, hexagonal and centered monoclinic. The apparent tetragonal and hexagonal crystals were grown in the presence of PEG 3350 and sodium formate near pH 7. The apparent tetragonal form diffracted to 2.7 A resolution and exhibited pseudo-merohedral twinning such that the true space group is P2(1)2(1)2(1) with four molecules in the asymmetric unit. The hexagonal form diffracted to 2.3 A resolution and belonged to space group P6(2)22 with one molecule in the asymmetric unit. Centered monoclinic crystals were grown in ammonium sulfate, diffracted to 2.3 A resolution and had two molecules in the asymmetric unit. Removing the histidine tag was important in order to obtain the C2 crystal form.

  12. Exploring the proline-dependent conformational change in the multifunctional PutA flavoprotein by tryptophan fluorescence spectroscopy.

    Science.gov (United States)

    Zhu, Weidong; Becker, Donald F

    2005-09-20

    The multifunctional PutA flavoprotein regulates proline utilization in Escherichia coli by switching from a cytosolic DNA-binding protein to a membrane-bound enzyme with proline dehydrogenase (PRODH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) activities. The transformation of PutA from a transcriptional repressor of the proline utilization (put) regulon to a peripheral membrane associated enzyme is mediated by a proline-dependent conformational change. Previously, limited proteolysis of PutA indicated that the conformational change involves a flexible domain of unknown function (residues 141-262) which is nearby the FAD-binding and PRODH active sites (residues 263-610). Here, we extend our understanding of the proline-dependent conformational change in PutA by investigating the intrinsic Trp fluorescence spectroscopic properties of a truncated PutA protein which contains residues 86-601 (PutA86-601) and only four Trp residues. The addition of proline to wild-type PutA86-601 decreases Trp fluorescence by 36%, indicating a substantial conformational change. An apparent rate constant of 0.59 +/- 0.06 s(-)(1) was determined for the fluorescence change by stopped-flow fluorescence measurements. The limiting rate constant for proline reduction of the FAD cofactor in PutA is 133 +/- 6 s(-)(1), demonstrating that FAD reduction precedes the conformational transition observed by Trp fluorescence. The nonreducing ligand l-tetrahydro-2-furoic acid mimics the decrease in Trp fluorescence induced by proline, indicating that both FAD reduction and ligand binding contribute to the observed conformational change in PutA86-601. W194 and W211, which are located in the flexible domain, were replaced by Phe in the PutA86-601 mutants W194F, W211F, and W194F/W211F to determine which residue is involved in the observed fluorescence change. Analysis of the PutA86-601 mutants indicated that W211 is the primary molecular marker of the conformational change caused by proline

  13. Amblyopia risk factor prevalence.

    Science.gov (United States)

    Arnold, Robert W

    2013-01-01

    In 2003, the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) published a set of risk factors for amblyopia. The intent was to promote uniformity of reporting and development in screening. Because this prevalence is not yet known, this meta-analysis is an attempt to estimate it. Major community preschool eye examination studies were reviewed and AAPOS cut-offs estimated. The approximate prevalence of anisometropia is 1.2%, hyperopia is 6%, astigmatism is 15%, myopia is 0.6%, strabismus is 2.5%, and visual acuity less than 20/40 is 6%. The mean combined prevalence is 21% ± 2% compared to a prevalence of amblyopia 20/40 and worse of 2.5%. Knowing risk factor prevalence simplifies validation efforts. Amblyopia screening with a risk factor sensitivity less than 100% is expected and desirable. Copyright 2013, SLACK Incorporated.

  14. The Rhizobium meliloti putA gene: its role in the establishment of the symbiotic interaction with alfalfa.

    Science.gov (United States)

    Jiménez-Zurdo, J I; García-Rodríguez, F M; Toro, N

    1997-01-01

    Little is known about the energy sources used by rhizobia during colonization, invasion and root nodule formation on leguminous plants. We have recently reported that an impaired proline metabolism in rhizobium meliloti leads to a reduced nodulation efficiency and competitiveness on alfalfa roots. In the present study we have characterized the R. meliloti proline dehydrogenase gene (putA) and addressed the question of its role in symbiosis. This rhizobial gene encodes a 1224-amino-acid-long polypeptide which is homologous to enteric bacteria, Rhodobacter capsulatus and Bradyrhizobium japonicum PutA proteins. Like the situation in these bacteria, sequence analysis identified the proline dehydrogenase (PDH) and pyrroline-5-carboxylate dehydrogenase (P5CDH) domains in the R. meliloti putA-encoded protein. Beta-galactosidase assays performed with free-living cells carrying a putA-lacZ transcriptional fusion revealed that R. meliloti putA gene expression is induced by proline, autoregulated by its encoded product, and independent of the general nitrogen regulatory system (Ntr). In addition, analysis of putA expression during the different steps of the symbiotic interaction with alfalfa showed that expression of this gene is turned on by the root exudates (RE), during root invasion and nodule formation, but not in differentiated nitrogen-fixing bacteroids. Furthermore, we show that the PutA- phenotype leads to a significant reduction of alfalfa root colonization by R. meliloti.

  15. The effect of dimple error on the horizontal launch angle and side spin of the golf ball during putting.

    Science.gov (United States)

    Richardson, Ashley K; Mitchell, Andrew C S; Hughes, Gerwyn

    2017-02-01

    This study aimed to examine the effect of the impact point on the golf ball on the horizontal launch angle and side spin during putting with a mechanical putting arm and human participants. Putts of 3.2 m were completed with a mechanical putting arm (four putter-ball combinations, total of 160 trials) and human participants (two putter-ball combinations, total of 337 trials). The centre of the dimple pattern (centroid) was located and the following variables were measured: distance and angle of the impact point from the centroid and surface area of the impact zone. Multiple regression analysis was conducted to identify whether impact variables had significant associations with ball roll variables, horizontal launch angle and side spin. Significant associations were identified between impact variables and horizontal launch angle with the mechanical putting arm but this was not replicated with human participants. The variability caused by "dimple error" was minimal with the mechanical putting arm and not evident with human participants. Differences between the mechanical putting arm and human participants may be due to the way impulse is imparted on the ball. Therefore it is concluded that variability of impact point on the golf ball has a minimal effect on putting performance.

  16. The flipped classroom, putting learning back into the hands of students

    Science.gov (United States)

    Torkelson, Virginia

    Flipping the classroom is a new style of teaching that puts learning back into the hands of the student and allows the teacher to facilitate each child's learning based on their individual needs. Three units of Chemistry were flipped to give the researcher experience and skill in this new ideology. Technology was used to create podcasts for student's to watch outside of the classroom. Student's used classroom time for problem-solving, activities, discussions and labs. From this experience as well as conferences, classroom observations of the flipping process in action and discussions with other teachers also using this new style of teaching, a handbook was written.

  17. Historical reflections on diet, exercise, and obesity: the recurring need to "put words into action".

    Science.gov (United States)

    Park, Roberta J

    2011-01-01

    According to a 2010 announcement by the Centers for Disease Control, more than one third of adults and nearly 20% of children in the United States are obese. Obesity and its attendant health issues are becoming a global problem. In spite of the fact that a monumental number of articles in important scientific and clinical journals now support what Plato and others have been setting forth for more than 2,000 years regarding proper diet and adequate exercise, far too little is being done to "put words into action." This article offers an overview of both lesser known and more familiar works that have addressed this issue.

  18. Green marketing - How to put an environmental spin on your energy product, service, program or project

    International Nuclear Information System (INIS)

    Flynn, J.

    1992-01-01

    This paper examines how some smart marketers have quickly picked up on the new consumer interest in protecting the environment, turned it into increased sales and profits and at the same time effectively increased energy conservation. They asked their product developers to improve the environmental benefits of their existing products and to design some new ones. Then they asked their advertising writers to put an environmental spin on their product advertising. Next they made frequent visits to the bank with the increased sales revenues from an expanding market share and at the same time are doing something worthwhile in energy and environmental conservation

  19. Putting the horse before the cart: a pragmatist analysis of knowledge

    Directory of Open Access Journals (Sweden)

    Luís M. Augusto

    2011-01-01

    Full Text Available The definition of knowledge as justified true belief is the best we presently have. However, the canonical tripartite analysis of knowledge does not do justice to it due to a Platonic conception of a priori truth that puts the cart before the horse. Within a pragmatic approach, I argue that by doing away with a priori truth, namely by submitting truth to justification, and by accordingly altering the canonical analysis of knowledge, this is a fruitful definition. So fruitful indeed that it renders the Gettier counterexamples vacuous, allowing positive work in epistemology and related disciplines.

  20. The innocence of carbon - the greenhouse effect put into question again

    International Nuclear Information System (INIS)

    Gervais, Francois

    2013-01-01

    The author of this book proposes an original and unusual point of view: carbon dioxide could be not so responsible of our problems. He puts into question again several issues and information dealing with various topics: the relationship between carbon level and temperature evolution, global warming, the issue of climate, renewable energies and energy efficiency, the content of the IPCC report. He states that the CO 2 greenhouse effect has reached its limits in the atmosphere, discusses the content of the 2007 IPCC report, comments the challenges for renewable energies, and the perspectives for nuclear fission and thermonuclear fusion

  1. To put nuclear technical expertise at the service of local authorities

    International Nuclear Information System (INIS)

    Laffin, R.; Domeneghetti, B.

    2016-01-01

    The MARN (Mission of support for the management of the nuclear risk) was founded in 1995 to assure the interface between the actors of the nuclear world (nuclear power plant operators, ASN and IRSN) and official bodies at the national scale (ministry of interior) or local scale (prefecture). The MARN takes part in the definition of the crisis exercises and is in charge of organizing the simulation of the media pressure during the exercise. The MARN can also intervene in a real nuclear crisis and its work consists in putting into perspective the technical appreciations and recommendations of nuclear experts and to translate them into operational options for the Prefect. (A.C.)

  2. Avulsion of the Lesser Trochanter Following a Shot Put Sport Session

    Directory of Open Access Journals (Sweden)

    Mohamed H. Grissa

    2017-03-01

    Full Text Available Avulsion of the lesser trochanter is an uncommon injury. In children and adolescents it usually occurs as a sports injury via traumatic avulsion of the psoas major tendon. In adults, isolated fractures of the lesser trochanter are most commonly pathological due to metastatic tumor invasion of the proximal femur. This case report documents how a 14-year-old boy, who presented with an avulsion of the lesser trochanter of the proximal femur following a seemingly atraumatic shot put session at a track and field event, was diagnosed and successfully treated with a conservative approach.

  3. 'Cloak' and 'Wholeness'– iconicity of the lexemes 'telo' and 'put'

    Directory of Open Access Journals (Sweden)

    Bašić Ivana

    2013-01-01

    Full Text Available Analysis of the lexemes telo and put arrives to the conclusion that the original iconicity of the lexeme telo “body” (<*tel- “a flat surface, a plank” represents the formation of the amorphous, unformed substance under a pressure, compressing, or division (a cutting off or separation and refers to the earth or tree as a form of matter. Put/plot (

  4. Practice Makes Efficient: Cortical Alpha Oscillations Are Associated With Improved Golf Putting Performance.

    Science.gov (United States)

    Gallicchio, Germano; Cooke, Andrew; Ring, Christopher

    2017-02-01

    Practice of a motor skill results in improved performance and decreased movement awareness. The psychomotor efficiency hypothesis proposes that the development of motor expertise through practice is accompanied by physiological refinements whereby irrelevant processes are suppressed and relevant processes are enhanced. The present study employed a test-retest design to evaluate the presence of greater neurophysiological efficiency with practice and mediation analyses to identify the factors accounting for performance improvements, in a golf putting task. Putting performance, movement-specific conscious processing, electroencephalographic alpha power and alpha connectivity were measured from 12 right-handed recreational golfers (age: M = 21 years; handicap: M = 23) before and after 3 practice sessions. As expected, performance improved and conscious processing decreased with training. Mediation analyses revealed that improvements in performance were partly attributable to increased regional gating of alpha power and reduced cross-regional alpha connectivity. However, changes in conscious processing were not associated with performance improvements. Increased efficiency was manifested at the neurophysiological level as selective inhibition and functional isolation of task-irrelevant cortical regions (temporal regions) and concomitant functional activation of task-relevant regions (central regions). These findings provide preliminary evidence for the development of greater psychomotor efficiency with practice in a precision aiming task.

  5. A Study of Families’ Experiences of Putting Their Elders in Nursing Homes

    Directory of Open Access Journals (Sweden)

    Farahnaz Chireh Hafshjani

    2016-11-01

    Full Text Available One of the major challenges facing society today is increasing proportion of its elderly population. Nowadays, elderliness along with its all psychological, socio-cultural, ideological and economic aspects have become a serious and challenging issue affecting families in developing and developed countries. Thus, the current study aimed to examine families’ experiences of putting their elders in nursing homes. A phenomenological research method was employed to pursue this qualitative study. The samples of the study were selected through purposive sampling method; and data collection proceeded until it reached to the data saturation within 10 participants. The instruments adopted by the researcher include note-taking and in-depth and unstructured interviews with the families of the elderly who put their elders in nursing homes. The obtained data were analyzed using Colaizzi’s seven-step process of analysis. The four general themes derived include isolation, peace, abusiveness, children’s inability to look after their elders and guilty conscience; each of which contained some sub-themes. According to the results, it is essential to take the social, economic and health support of the elderly into consideration and to provide the necessary context for improving the life quality of the elderly residing in nursing homes through formulating, planning and making appropriate policies.

  6. Putting Urban Regeneration Projects in Order: An Example of a Decision Support System

    Directory of Open Access Journals (Sweden)

    Ayşegül ALAYBEYOĞLU

    2016-12-01

    Full Text Available There is an urgent need of renewal of metropolitan cities in Turkey which heavily consist of irregular, low quality building stock which have occurred in the last 60 years. However urban regeneration projects are large and expensive construction projects. Therefore, due to technical and economic barriers, it is not possible for regeneration authorities to start the projects for the whole city in the same time. Thus they carry out projects step by step, one after another. Projects are started from the most problematic and urgent ones to the least problematic ones. However, regeneration authorities face with problems when putting regeneration projects in order, i.e. determining which neighborhood should be regenerated earlier than the other one. In addition to that, they are having difficulties when explaining their decisions to the public. At this point, a computer-based Fuzzy Logic decision support system can help them reach more convenient decisions. Also, with this way, the decisions will have a scientific basis, therefore it can be easier to announce them to the public and avoid speculation. In this paper, an example of a decision support system based on Fuzzy Logic for putting urban regeneration project areas in order was presented.

  7. Putting the Testing Effect to the Test. Why and When is Testing effective for Learning in Secondary School

    NARCIS (Netherlands)

    Dirkx, Kim

    2014-01-01

    Dirkx, K. J. H. (2014, 11 April). Putting the testing effect to the test. Why and when is testing effective for learning in secondary school. Unpublished doctoral dissertation. Heerlen: Open University of the Netherlands

  8. SHOT PUT O’BRIAN TECHNIQUE, EXTENDING THE ANALYSIS OF TECHNIQUE FROM FOUR TO SIX PHASES WITH THE DESCRIPTION

    Directory of Open Access Journals (Sweden)

    Zlatan Saračević

    2011-09-01

    Full Text Available Due to the complexity of the motion, shot put technique is described in phases for easier analysis, easer learning of technique and error correction. It is complete so that in its implementation the transition from phase to phase is not noticed. In aforementioned and described phases of O'Brian spinal shot put technique a large distance, emptiness and disconnection appear between the initial position phase and a phase of overtaking the device, which in the training methods and training technique in primary and secondary education, as well as for students and athletes beginners in shot put represents a major problem regarding connecting, training and technique advancement. Therefore, this work is aimed at facilitating the methods of training of shot put technique, extending from four to six phases, which have been described and include the complete O'Brian technique.

  9. Perceived hole size, performance, and body movement during putting in children with and without probable developmental coordination disorder.

    Science.gov (United States)

    Chen, Fu-Chen; Wu, Sheng-Kuang

    2013-10-01

    The purpose of this study was to examine the relationships between perceived hole size (perception), performance, and body movement (action) in golf putting for children with probable developmental coordination disorder (DCD) and typically developing children (TDC). Forty-eight children (24 probable DCD, 24 TDC) performed putting in easy and hard conditions. Body movement was measured during putting, performance was measured as the distance between ball and hole, and perceived hole size was recorded using a Microsoft Paint drawing exercise 1 m away from the hole. The present results revealed that perceived hole size was positively related to putting performance, body movement was negatively associated with putting performance, and that there were negative correlations between body movement and perceived hole size. While children with probable DCD tended to perceive the hole as smaller, perform worse, and show more body movement, TDC exhibited the opposite. These findings help characterize the relationships between perception, performance, and action in children with probable DCD and TDC during golf putting.

  10. Characterization of a bifunctional PutA homologue from Bradyrhizobium japonicum and identification of an active site residue that modulates proline reduction of the flavin adenine dinucleotide cofactor.

    Science.gov (United States)

    Krishnan, Navasona; Becker, Donald F

    2005-06-28

    PutA is a bifunctional flavoenzyme in bacteria that catalyzes the four-electron oxidation of proline to glutamate. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization (put) genes and thus is trifunctional. In this work, we have begun to assess differences between bifunctional and trifunctional PutA enzymes by examining the PutA protein from Bradyrhizobium japonicum (BjPutA). Primary structure analysis of BjPutA shows it lacks the DNA-binding domain of E. coli PutA (EcPutA). Consistent with this prediction, purified BjPutA does not exhibit DNA-binding activity in native gel mobility shift assays with promoter regions of the putA gene from B. japonicum. The catalytic and redox properties of BjPutA were characterized and a reduction potential (E(m)) value of -0.132 V (pH 7.5) was determined for the bound FAD/FADH(2) couple in BjPutA that is significantly more negative ( approximately 55 mV) than the E(m) for EcPutA-bound FAD. The more negative E(m) value thermodynamically limits proline reduction of the FAD cofactor in BjPutA. In the presence of phospholipids, reduction of BjPutA is stimulated, suggesting lipids influence the FAD redox environment. Accordingly, an E(m) value of -0.114 V (pH 7.5) was determined for BjPutA-bound FAD in the presence of polar lipids. The molecular basis for the lower reduction potential of FAD in BjPutA relative to EcPutA was explored by site-directed mutagenesis. Amino acid sequence alignment between BjPutA and EcPutA indicates only one difference in active site residues near the isoalloxazine ring of FAD: Val402 in EcPutA is substituted at the analogous position in BjPutA with Ala310. Replacement of A310 by Val in the BjPutA mutant A310V raised the reduction potential of bound FAD relative to wild-type BjPutA to an E(m) value of -0.09 V (pH 7.5). The >40-mV positive shift in the potential of the BjPutA mutant A310V suggests that the corresponding Val residue in EcPut

  11. Forecasting future prevalence of type 2 diabetes mellitus in Syria.

    Science.gov (United States)

    Al Ali, Radwan; Mzayek, Fawaz; Rastam, Samer; M Fouad, Fouad; O'Flaherty, Martin; Capewell, Simon; Maziak, Wasim

    2013-05-25

    Type 2 diabetes mellitus (T2DM) is increasingly becoming a major public health problem worldwide. Estimating the future burden of diabetes is instrumental to guide the public health response to the epidemic. This study aims to project the prevalence of T2DM among adults in Syria over the period 2003-2022 by applying a modelling approach to the country's own data. Future prevalence of T2DM in Syria was estimated among adults aged 25 years and older for the period 2003-2022 using the IMPACT Diabetes Model (a discrete-state Markov model). According to our model, the prevalence of T2DM in Syria is projected to double in the period between 2003 and 2022 (from 10% to 21%). The projected increase in T2DM prevalence is higher in men (148%) than in women (93%). The increase in prevalence of T2DM is expected to be most marked in people younger than 55 years especially the 25-34 years age group. The future projections of T2DM in Syria put it amongst countries with the highest levels of T2DM worldwide. It is estimated that by 2022 approximately a fifth of the Syrian population aged 25 years and older will have T2DM.

  12. Climate Wrongs and Human Rights. Putting people at the heart of climate-change policy

    Energy Technology Data Exchange (ETDEWEB)

    Raworth, K. (ed.) (and others)

    2008-09-15

    In failing to tackle climate change with urgency, rich countries are effectively violating the human rights of millions of the world's poorest people. Continued excessive greenhouse-gas emissions primarily from industrialised nations are - with scientific certainty - creating floods, droughts, hurricanes, sea-level rise, and seasonal unpredictability. The result is failed harvests, disappearing islands, destroyed homes, water scarcity, and deepening health crises, which are undermining millions of peoples' rights to life, security, food, water, health, shelter, and culture. Such rights violations could never truly be remedied in courts of law. Human-rights principles must be put at the heart of international climate-change policy making now, in order to stop this irreversible damage to humanity's future.

  13. Putting to point the production process of iodine-131 by dry distillation (Preoperational tests)

    International Nuclear Information System (INIS)

    Alanis M, J.

    2002-12-01

    With the purpose of putting to point the process of production of 131 I, one of the objectives of carrying out the realization of operational tests of the production process of iodine-131, it was of verifying the operation of each one of the following components: heating systems, vacuum system, mechanical system and peripheral equipment that are part of the production process of iodine-131, another of the objectives, was settling down the optimal parameters that were applied in each process during the obtaining of iodine-131, it is necessary to point out that this objective is very important, since the components of the equipment are new and its behavior during the process is different to the equipment where its were carried out the experimental studies. (Author)

  14. The use of pulsed high-speed liquid jet for putting out gas blow-out

    Directory of Open Access Journals (Sweden)

    A Semko

    2016-10-01

    Full Text Available The experimental analysis of putting out a gas blow-out with the help of pulse liquid flow with high velocity, which generates by powder pulse water-cannon are carried out. The flow velocity resides in range from 300 to 600 m/s in experiments depends on charge energy. Velocity of the flow head right near the gas flame determined with the help of laser contactless measuring instrument of velocity. Photography of flow was carried out. According to the preliminary test results the hydrodynamic parameters of powder pulse water-cannon for obtaining liquid flow with depend velocity are calculated. It is shown, that around the liquid flow of high velocity in air produced fine water spray with high velocity in large cross section area that effective knock down the gas blow-out at the distance 5-20 m from installation.

  15. Development of an OLAP Based Fuzzy Logic System for Supporting Put Away Decision

    Directory of Open Access Journals (Sweden)

    S.H.Chung

    2009-10-01

    Full Text Available In today`s rapidly changing and globally volatile world, manufacturers pay strong efforts on conducting lean production, outsourcing their components, and management on the complex supply chain. Warehouse management plays a vital role to be a successful player in the any kinds of industry which put-away process is a key activity that brings significant influence and challenges to warehouse performance. In this dynamic operating environment, minimizing the operation mistakes and providing accurate real time inventory information to stakeholder become the basic requirements to be an order qualifier. An OLAP based intelligent system called Fuzzy Storage Assignment System (FSAS is proposed to increase availability of decision support data and convert the human knowledge into system for tackling the storage location assignment problem (SLAP. To validate the feasibility of this proposed system, a prototype will be worked out for a third party logistics company.

  16. Protests put top job for ex-CERN boss in limbo

    Science.gov (United States)

    2008-02-01

    When Luciano Maiani was selected by the Italian government at the end of December to run the country's largest research organization, the National Research Council (CNR), his appointment seemed a formality. His nomination was warmly welcomed by Italian researchers, who believe that his scientific credentials and administrative experience make him the ideal person to try and turn round the demoralized and bureaucratic CNR, and minister for universities and research, Fabio Mussi, extolled his virtues. But as Physics World went to press, Maiani's appointment remained in limbo, with the members of parliament previously expected to rubber stamp the selection putting their decision on hold after discovering that Maiani was one of the 66 letter writers asking for the Pope's visit to be annulled.

  17. Putting Yourself on the Line: Self-Esteem and Expressing Affection in Romantic Relationships.

    Science.gov (United States)

    Luerssen, Anna; Jhita, Gugan Jote; Ayduk, Ozlem

    2017-07-01

    Although expressing affection is an important way to connect to a romantic partner, it also involves putting yourself on the line-revealing dependence on your partner. Extending the risk-regulation model, we hypothesized that individuals with lower self-esteem (SE), who are concerned about vulnerability in relationships, experience less rewarding reactions to expressing affection, and believe that their partners respond less positively to receiving affection. We assessed these predictions across two studies that measured retrospective reports, reactions to an in vivo exchange and responses in daily life. We found that participants with lower SE expressed less affection and experienced less positive emotional, cognitive, and physiological reactions when doing so. Participants with lower SE believed that their partners derived fewer benefits from their affection despite that their partners experienced normative boosts in positive emotion and relationship satisfaction during these exchanges. The consequences of these findings for relationship functioning and SE are discussed.

  18. Putting our differences to work the fastest way to innovation, leadership, and high performance

    CERN Document Server

    Kennedy, Debbe

    2008-01-01

    In this rapidly changing world, organisations of every type are finding that putting our differences to work is the most powerful accelerator for generating new levels of innovation, energy, leadership and employee engagement needed for high performance. This new book is a practical guide to the strategies and steps needed to make differences the drivers of success. Debbe Kennedy shows that leveraging all the dimensions of difference -- from thinking styles, perspectives, experience, position, goals, competencies, work habits, culture and management style to traditional diversity rubrics such as gender, race, ethnicity, physical abilities, sexual orientation and age -- can accelerate teams' and organisations' performance. Kennedy's book is a practical guide for leaders at all levels that begins with a compelling invitation to pioneer a new era leadership history. It establishes the need for change, sets the course of action, offers proof points and defines five distinctive qualities all leaders need to add to...

  19. Putting the brakes on aggression toward a romantic partner: the inhibitory influence of relationship commitment.

    Science.gov (United States)

    Slotter, Erica B; Finkel, Eli J; Dewall, C Nathan; Pond, Richard S; Lambert, Nathaniel M; Bodenhausen, Galen V; Fincham, Frank D

    2012-02-01

    Why do people behave aggressively toward romantic partners, and what can put the brakes on this aggression? Provocation robustly predicts aggression in both intimate and nonintimate relationships. Four methodologically diverse studies tested the hypothesis that provocation severity and relationship commitment interact to predict aggression toward one's romantic partner, with the aggression-promoting effects of provocation diminishing as relationship commitment increases. Across all four studies, commitment to one's romantic relationship inhibited aggression toward one's partner when individuals were severely (but not mildly) provoked. Study 4 tested the hypothesis that this Partner Provocation × Commitment interaction effect would be strong among individuals high in dispositional tendencies toward retaliation but weak (perhaps even nonexistent) among individuals low in such tendencies. Discussion emphasizes the importance of understanding instigating, impelling, and inhibiting processes in the perpetration of aggression toward intimate partners.

  20. Hit, Robbed, and Put Down (but not Bullied): Underreporting of Bullying by Minority and Male Students.

    Science.gov (United States)

    Lai, Tianjian; Kao, Grace

    2018-03-01

    To tackle adolescent bullying and identify students most vulnerable to being bullied, it is essential to examine both occurrences of bullying behaviors and students' own likelihoods of reporting bullying. This study examines ethnic and gender differences in students' odds of reporting bullying using the Education Longitudinal Study of 2002, a nationally representative study of United States high school sophomores (N = 15,362; ages 15-19; 50.2% female). Compared to White and female students, minority (particularly Black and Hispanic) and male students report comparable or greater experiences of bullying behaviors (such as being threatened, hit, put down by peers, or having belongings forced from them, stolen or damaged), but are less likely to report that they have been "bullied." These findings point to racialized and gendered differences in reporting bullying experiences such that indicators of "weakness" in peer relations may carry a greater stigma for minority and male students.

  1. Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.

    Science.gov (United States)

    Zhang, Min; White, Tommi A; Schuermann, Jonathan P; Baban, Berevan A; Becker, Donald F; Tanner, John J

    2004-10-05

    Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the flavin-dependent oxidation of proline to Delta(1)-pyrroline-5-carboxylate. Here we present a structure-based study of the PRODH active site of the multifunctional Escherichia coli proline utilization A (PutA) protein using X-ray crystallography, enzyme kinetic measurements, and site-directed mutagenesis. Structures of the PutA PRODH domain complexed with competitive inhibitors acetate (K(i) = 30 mM), L-lactate (K(i) = 1 mM), and L-tetrahydro-2-furoic acid (L-THFA, K(i) = 0.2 mM) have been determined to high-resolution limits of 2.1-2.0 A. The discovery of acetate as a competitive inhibitor suggests that the carboxyl is the minimum functional group recognized by the active site, and the structures show how the enzyme exploits hydrogen-bonding and nonpolar interactions to optimize affinity for the substrate. The PRODH/L-THFA complex is the first structure of PRODH with a five-membered ring proline analogue bound in the active site and thus provides new insights into substrate recognition and the catalytic mechanism. The ring of L-THFA is nearly parallel to the middle ring of the FAD isoalloxazine, with the inhibitor C5 atom 3.3 A from the FAD N5. This geometry suggests direct hydride transfer as a plausible mechanism. Mutation of conserved active site residue Leu432 to Pro caused a 5-fold decrease in k(cat) and a severe loss in thermostability. These changes are consistent with the location of Leu432 in the hydrophobic core near residues that directly contact FAD. Our results suggest that the molecular basis for increased plasma proline levels in schizophrenic subjects carrying the missense mutation L441P is due to decreased stability of human PRODH2.

  2. Putting the learner in the spotlight – Future directions for English teachers

    Directory of Open Access Journals (Sweden)

    Anne P A Swan

    2013-10-01

    Full Text Available This paper asserts that English teachers’ understanding of their professionalism enables them to ‘put the learner in the spotlight’ through their highly-developed awareness of local contexts of English use. Changing attitudes to English language teacher identity include a revaluation of the’ native-non-native speaker’ dichotomy which is fast becoming irrelevant as teachers assert new identities based on factors such as professional beliefs about their teaching, understanding their students’ needs and understanding the role of English in their contexts. In a globalising world, these aspects no longer require ‘so-called’ native speaker skills, such as pronunciation and knowledge of ‘English’ culture. In fact, dwelling at length on the issues surrounding native and non-native speaker teacher identity tends to cloud understanding of what qualities English teachers need. Interviews with multilingual teachers of English, working in a variety of countries, have revealed an understanding of the diminishing importance of the ‘native speaker’ and the concomitant growth in the confidence of the multilingual teacher. This confidence has been acquired through depth of linguistic knowledge, through observance of other cultures, and through resistance to the encroachment of English by finding a place for the language which satisfies the needs of multilingual users without requiring subservience. In discovering these strengths of multilingual teachers, I show how stepping outside the boundaries of one’s own limited environment allows English language teachers, wherever they come from, to develop a truly enlightened international professionalism which puts learners firmly in the spotlight.

  3. Re-establishing What Went Wrong Before: The Greenspan Put as Macroeconomic Modellers’ New Normal

    Directory of Open Access Journals (Sweden)

    Matthew Watson

    2014-06-01

    Full Text Available Almost a decade after his retirement Alan Greenspan remains the world’s most immediately recognisable and highest profile central banker. This article reviews Greenspan’s ostensible move away from efficient markets theorising as he has tried to come to terms with the patterns of ‘euphoria’ and ‘fear’ he believes explain the build-up to the global financial crisis. In truth, though, it looks much more like an attempt to rescue the reputation of his free market models in the face of an increasing number of sceptics. Greenspan’s new memoire fails to acknowledge what, in effect, was the free put option the Federal Reserve provided to Wall Street traders under his leadership. Indeed, it goes as far as to promote a visualisation technique for how macroeconomic modellers should view the basic structure of the market environment which treats the now increasingly infamous ‘Greenspan put’ as an ostensibly formal component of asset prices. The style of policymaking that helped to stoke such extreme asset price inflation prior to the crisis is now embedded:(i within the class of models that Greenspan has presented as the post-crisis antidote to efficient markets theorising; and (ii within the recent historical data being used in the calibration tests of the models’ efficacy. What macroeconomic modellers can see in the market environment when embracing the supposedly new reality of euphoria and fear is a manifestation of what the prior existence of the Greenspan put first brought into view

  4. Real-time index for predicting successful golf putting motion using multichannel EEG.

    Science.gov (United States)

    Muangjaroen, Piyachat; Wongsawat, Yodchanan

    2012-01-01

    A skill in goal-directed sport performance is an ability involving with many factors of both external and internal concernment. External factors are still developed while internal factors are challenged topic to understand for improving the performance. Internal concernment is explained an effective performance as estimation, solving strategy, planning and decision on the brain. These conjunctions are relevant to somatosensory information, focus attention and fine motor control of cortical activity. Five skilled right-handed golfers were recruited to be subjected of studying the criteria on how to predict golf putt success. Each of their putts was calculated in power spectral analysis by comparing to the pre-movement period. Successful and unsuccessful putt were classified by focusing on the frontal-midline(Fz), parietal-midline(Pz), central midline(Cz), left central(C3) and right central(C4) which supported by few consistency studies that they are related to a primary sensory motor area, focus attention and working memory processing. Results were shown that high alpha power on C4, theta power on Fz, theta power and high alpha power on Pz can be calculated to use as index of predicting golf putt success. Real-time monitoring system with friendly GUI was proposed in this study as promising preliminary study. Expected goal in the future is to apply this real-time golf putting prediction system into a biofeedback system to increase the golf putting's accuracy. However, it still needs more subjects to increase credibility and accuracy of the prediction.

  5. Myopia: Prevalence and Progression

    Science.gov (United States)

    1989-01-01

    D~ L LL Myopia Prevalence and Progression DTIC ELECTE ! SEP 19 1989 C _ _ ’ l A 9 ,3 /5i MYOPIA: PREVALENCE AND PROGRESSION Working Group on Myopia... WALLMAN , Department of Biology, City University of New York AC"esiOf) For NTtSCF& DTjC T;,jE 0 ey ____ (:3 1U: or iii COMMITTEE ON VISION ANTHONY J. ADAMS...provided by Carol Metcalf and Gora P. Lerma, for which the working group is grateful. Christine L . McShane, editor of the Commission on Behavioral and

  6. Evidence that the C-terminal domain of a type B PutA protein contributes to aldehyde dehydrogenase activity and substrate channeling.

    Science.gov (United States)

    Luo, Min; Christgen, Shelbi; Sanyal, Nikhilesh; Arentson, Benjamin W; Becker, Donald F; Tanner, John J

    2014-09-09

    Proline utilization A (PutA) is a bifunctional enzyme that catalyzes the oxidation of proline to glutamate. Structures of type A PutAs have revealed the catalytic core consisting of proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) modules connected by a substrate-channeling tunnel. Type B PutAs also have a C-terminal domain of unknown function (CTDUF) that is absent in type A PutAs. Small-angle X-ray scattering (SAXS), mutagenesis, and kinetics are used to determine the contributions of this domain to PutA structure and function. The 1127-residue Rhodobacter capsulatus PutA (RcPutA) is used as a representative CTDUF-containing type B PutA. The reaction progress curve for the coupled PRODH-P5CDH activity of RcPutA does not exhibit a time lag, implying a substrate channeling mechanism. RcPutA is monomeric in solution, which is unprecedented for PutAs. SAXS rigid body modeling with target-decoy validation is used to build a model of RcPutA. On the basis of homology to aldehyde dehydrogenases (ALDHs), the CTDUF is predicted to consist of a β-hairpin fused to a noncatalytic Rossmann fold domain. The predicted tertiary structural interactions of the CTDUF resemble the quaternary structural interactions in the type A PutA dimer interface. The model is tested by mutagenesis of the dimerization hairpin of a type A PutA and the CTDUF hairpin of RcPutA. Similar functional phenotypes are observed in the two sets of variants, supporting the hypothesis that the CTDUF mimics the type A PutA dimer interface. These results suggest annotation of the CTDUF as an ALDH superfamily domain that facilitates P5CDH activity and substrate channeling by stabilizing the aldehyde-binding site and sealing the substrate-channeling tunnel from the bulk medium.

  7. Campus Suicide Prevention and Intervention: Putting Best Practice Policy into Action

    Science.gov (United States)

    Washburn, Cheryl A.; Mandrusiak, Michael

    2010-01-01

    Findings from biannual American College Health Association-National College Health Assessment surveys have highlighted the prevalence of depression, suicidal ideation, and attempted suicides on Canadian university campuses and the need for comprehensive suicide prevention programs. This article explores how one large western Canadian university…

  8. prevalence and risk

    African Journals Online (AJOL)

    owner

    2012-12-26

    Dec 26, 2012 ... increase the frequency of occurrence of hypoglycaemia. Hypoglycaemia is a ... not only in increased frequency of falciparum malaria, but also .... of illness before presentation. Table 3: Prevalence of hypoglycaemia according to time of last meal. Table 4, shows the higher the parasite density the greater.

  9. Prevalence. Ascice. faotic dogs.

    African Journals Online (AJOL)

    BSN

    reproduction. body weight evaluation and other existing ph}siological and pathological condn1ons. REFERE:\\CES. Datong. P. G. (2003). Seasonal Prevalence of Ascites in Dogs. '\\atonal Diploma project in. Animal I lealth and production Technology. FCAHPT. I'\\\\ RI. Vom .. Plateau State Pp 1-. 28. Gourley. I. M., and Vasseur ...

  10. Prevalence of Esophageal Adenocarcinoma

    African Journals Online (AJOL)

    multiruka1

    esophagus. It is not known whether the trend is similar locally. Objective: To describe the prevalence and clinicopathological characteristics of adenocarcinoma of .... which is in keeping with trends observed in other regions of the world. Most of the patients present late with severe degrees of dysphagia, with wasting seen in.

  11. Putts that get missed on the right: investigating lateralized attentional biases and the nature of putting errors in golf.

    Science.gov (United States)

    Roberts, Ross; Turnbull, Oliver H

    2010-02-01

    Although the effects of lateral biases in visual attention ("pseudoneglect") have been examined in real-world settings, this phenomenon has yet to be considered within the realm of sporting performance. In the present study, we investigated the effects of pseudoneglect on putting errors in golf. Novice golfers (n = 30) performed 90 putting trials followed by a series of pseudoneglect tasks: requiring participants to bisect lines manually and with a biomechanical bisection tool. All pseudoneglect measures were performed with both the left and right hands. Results demonstrated a leftward bias for all the pseudoneglect tasks, and a rightward bias for putting error. Moreover, the results revealed that individuals who bisected lines to the left on the Bisection Tool (the typical class of pseudoneglect error for humans) with the left hand (the hand that typically produces the greatest pseudoneglect bias) displayed significantly smaller rightward putting errors. Moreover, these individuals also holed more putts. No other pseudoneglect tasks were shown to impact on putting performance. Our findings suggest that lateralized attentional biases have a significant effect on sport performance; they appear to influence a wide range of precision-based sports (e.g. shooting, archery). Findings are also discussed in terms of the processes that are likely to be involved in this effect.

  12. Regulation of gene expression by repressor localization: biochemical evidence that membrane and DNA binding by the PutA protein are mutually exclusive.

    OpenAIRE

    Muro-Pastor, A M; Ostrovsky, P; Maloy, S

    1997-01-01

    The PutA protein from Salmonella typhimurium is a bifunctional enzyme that catalyzes the oxidation of proline to glutamate, a reaction that is coupled to the transfer of electrons to the electron transport chain in the cytoplasmic membrane. The PutA protein is also a transcriptional repressor that regulates the expression of the put operon in response to the availability of proline. Despite extensive genetic and biochemical studies of the PutA protein, it was not known if the PutA protein car...

  13. Five styles of Customer Knowledge Management, and how smart companies put them into action

    OpenAIRE

    Gibbert, Michael; Leibold, Marius; Probst, Gilbert

    2002-01-01

    In the aftermath of the knowledge economy, smart corporations begin to realize that the proverbial "if we only know what we know" also includes "if we only knew what our customers know." In this paper, the authors discuss the concept of Customer Knowledge Management (CKM), which refers to the management of knowledge from customers, i.e. knowledge resident in customers, in contrast to knowledge about customers, e.g. customer characteristics and preferences prevalent in previous work on knowled...

  14. PREVALENCE OF VAGINITIS IN FEMALES ATTENDING NATIONAL MEDICAL COLLEGE AND TEACHING HOSPITAL, BIRGUNJ, NEPAL

    OpenAIRE

    Dipak Bhargava*, Sanjay Kar, Abhilasha Saha, Mukesha Saha

    2016-01-01

    Vaginitis which include bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis are the major gynaecological problems associated with the females of reproductive age group. In this study a sincere effort has been put to find out the prevalence of common types of vaginitis in females attending the Gynaecological outpatient Department of National medical college and teaching hospital, Birgunj from 1st January, 2016 to 30th June, 2016. A total of three hundred and thirty high vaginal sw...

  15. Disordered Gambling Prevalence

    DEFF Research Database (Denmark)

    Harrison, Glenn W.; Jessen, Lasse J.; Lau, Morten

    2018-01-01

    of detectable risk with these corrections, since gambling behavior is positively correlated with the decision to participate in gambling surveys. We also find that imposing a threshold gambling history leads to underestimation of the prevalence of gambling problems.......We study Danish adult gambling behavior with an emphasis on discovering patterns relevant to public health forecasting and economic welfare assessment of policy. Methodological innovations include measurement of formative in addition to reflective constructs, estimation of prospective risk...... for developing gambling disorder rather than risk of being falsely negatively diagnosed, analysis with attention to sample weights and correction for sample selection bias, estimation of the impact of trigger questions on prevalence estimates and sample characteristics, and distinguishing between total...

  16. Putting social impact assessment to the test as a method for implementing responsible tourism practice

    Energy Technology Data Exchange (ETDEWEB)

    McCombes, Lucy, E-mail: l.mccombes@leedsbeckett.ac.uk [International Centre for Research in Events, Tourism and Hospitality (ICRETH), Leeds Beckett University, Headingley Campus, Macaulay Hall 103, Leeds LS6 3QS (United Kingdom); Vanclay, Frank, E-mail: frank.vanclay@rug.nl [Professor of Cultural Geography, Faculty of Spatial Sciences, University of Groningen, PO Box 800, 9700AV Groningen (Netherlands); Evers, Yvette, E-mail: y.evers@tft-earth.org [The Forest Trust, Chemin de Chantavril 2, 1260 Nyon (Switzerland)

    2015-11-15

    The discourse on the social impacts of tourism needs to shift from the current descriptive critique of tourism to considering what can be done in actual practice to embed the management of tourism's social impacts into the existing planning, product development and operational processes of tourism businesses. A pragmatic approach for designing research methodologies, social management systems and initial actions, which is shaped by the real world operational constraints and existing systems used in the tourism industry, is needed. Our pilot study with a small Bulgarian travel company put social impact assessment (SIA) to the test to see if it could provide this desired approach and assist in implementing responsible tourism development practice, especially in small tourism businesses. Our findings showed that our adapted SIA method has value as a practical method for embedding a responsible tourism approach. While there were some challenges, SIA proved to be effective in assisting the staff of our test case tourism business to better understand their social impacts on their local communities and to identify actions to take. - Highlights: • Pragmatic approach is needed for the responsible management of social impacts of tourism. • Our adapted Social impact Assessment (SIA) method has value as a practical method. • SIA can be embedded into tourism businesses existing ‘ways of doing things’. • We identified challenges and ways to improve our method to better suit small tourism business context.

  17. Putting social impact assessment to the test as a method for implementing responsible tourism practice

    International Nuclear Information System (INIS)

    McCombes, Lucy; Vanclay, Frank; Evers, Yvette

    2015-01-01

    The discourse on the social impacts of tourism needs to shift from the current descriptive critique of tourism to considering what can be done in actual practice to embed the management of tourism's social impacts into the existing planning, product development and operational processes of tourism businesses. A pragmatic approach for designing research methodologies, social management systems and initial actions, which is shaped by the real world operational constraints and existing systems used in the tourism industry, is needed. Our pilot study with a small Bulgarian travel company put social impact assessment (SIA) to the test to see if it could provide this desired approach and assist in implementing responsible tourism development practice, especially in small tourism businesses. Our findings showed that our adapted SIA method has value as a practical method for embedding a responsible tourism approach. While there were some challenges, SIA proved to be effective in assisting the staff of our test case tourism business to better understand their social impacts on their local communities and to identify actions to take. - Highlights: • Pragmatic approach is needed for the responsible management of social impacts of tourism. • Our adapted Social impact Assessment (SIA) method has value as a practical method. • SIA can be embedded into tourism businesses existing ‘ways of doing things’. • We identified challenges and ways to improve our method to better suit small tourism business context

  18. Teach Like a Champion: 49 Techniques That Put Students on the Path to College, Doug Lemov

    Directory of Open Access Journals (Sweden)

    Jaliene Hollabaugh

    2011-01-01

    Full Text Available Doug Lemov collected and compiled approximately ten years of field notes on the teaching techniques of effective teachers in Teach Like A Champion: 49 Techniques That Put Students On The Path To College. Effective teachers were classified as those whose students excelled on state standardised tests. Lemov’s text addresses the topics of high student academic expectations, teacher planning, lesson organisation and delivery, student engagement, classroom culture, student behavioural expectations, the building of character and trust, teacher pacing, and critical thinking. In addition to the forty-nine techniques, Lemov argues in the latter half of the textbook that all teachers need to be “Reading” teachers. This textbook could be considered a proficiency-based educational model resource; examples of teachers who plan their objectives, formative assessments, and individualised learning opportunities in a way that achieves high student standardised test scores is a focus of the text. Teach Like A Champion is written for mass audiences and its content is applicable for teachers, preservice teachers, and those who hire and/or provide professional development for educators.

  19. Harnessing the uncertainty monster: Putting quantitative constraints on the intergenerational social discount rate

    Science.gov (United States)

    Lewandowsky, Stephan; Freeman, Mark C.; Mann, Michael E.

    2017-09-01

    There is broad consensus among economists that unmitigated climate change will ultimately have adverse global economic consequences, that the costs of inaction will likely outweigh the cost of taking action, and that social planners should therefore put a price on carbon. However, there is considerable debate and uncertainty about the appropriate value of the social discount rate, that is the extent to which future damages should be discounted relative to mitigation costs incurred now. We briefly review the ethical issues surrounding the social discount rate and then report a simulation experiment that constrains the value of the discount rate by considering 4 sources of uncertainty and ambiguity: Scientific uncertainty about the extent of future warming, social uncertainty about future population and future economic development, political uncertainty about future mitigation trajectories, and ethical ambiguity about how much the welfare of future generations should be valued today. We compute a certainty-equivalent declining discount rate that accommodates all those sources of uncertainty and ambiguity. The forward (instantaneous) discount rate converges to a value near 0% by century's end and the spot (horizon) discount rate drops below 2% by 2100 and drops below previous estimates by 2070.

  20. VALUATION OF OPEN SOURCE SOFTWARE: HOW DO YOU PUT A VALUE ON FREE?

    Directory of Open Access Journals (Sweden)

    Jesús García-García

    2013-04-01

    Full Text Available The aim of this study is to assess the financial reporting framework applied to open source software. Open sourcing software developments means sharing technology and resources with communities worldwide to help eliminate the digital divide, create economic opportunity, and support equal access to technology. Therefore, a methodological approach is needed to assess properly the performance and the value generation potential and to put such measure into organizational reports. International financial reporting framework is checked over conditions to allow value recognition of open sourced assets. Linux kernel development value is estimated to reflect worth of open source developments despite absence of book value due to inexistence of a single cost source. Several attempts to estimate a valuation of open source software have been performed previously. However, this study is the first to judge suitability of accounting framework to report on this value. The main finding is that open sourced assets do not fully accomplish conditions to be included in financial reports. We seek to stimulate academic and professional debate about the pursuit of valuation of a large and efficient ecosystem of software innovation, freely available to society.

  1. Re-energising Europe. Putting the EU on track for 100% renewable energy

    Energy Technology Data Exchange (ETDEWEB)

    White, A.; Anderson, J. [WWF European Policy Office, Brussels (Belgium)

    2013-02-15

    The report shows where Europe needs to be by 2030 in order to reach a fully renewable energy system by 2050. The key findings are that Europe has significant untapped potential for cutting energy use and maximising indigenous power sources that could deliver cheaper and more secure energy. However, this potential is at risk because of a lack of political ambition. There is a particular need for greater clarity on policy frameworks for renewable energy and energy efficiency after 2020 just one investment cycle away. Based on recent research by ECOFYS for WWF, by 2030, the EU: (a) could be using at least 38% less energy (compared to a business as usual projection; (b) could be generating more than 40% of its energy from renewable sources, and (c), by doing both, could reduce its energy related greenhouse emissions by 50% compared to 1990 levels. Achieving such levels would put the EU on track to delivering a 100% renewably powered energy system by 2050 at the latest. It should be noted that while biomass use has been assessed based on the global model, a more detailed sustainability vision for biomass use in Europe is needed.

  2. Putting students in charge: a symposium on student-centered learning.

    Science.gov (United States)

    Rangachari, P K

    2010-04-01

    Many symposia and workshops are held to discuss issues of student-centered learning, but few put students in charge. An international meeting was held at McMaster University, Hamilton, Ontario, Canada, to discuss Student-Centered Learning in the Life and Health Sciences where there were no plenary, oral, or poster presentations. Sessions were run in a problem-based, small-group format. Educational problems written specifically for the symposium served as springboards for learning. Undergraduate and graduate science students took center stage by taking an active role in the planning and organization of the event and serving as chairs and facilitators for the sessions. In addition, they summarized the sessions in written reports, which thus enabled their opinions to be documented. Eminent educators from several countries (Australia, Denmark, Spain, Portugal, Finland, the UK, and the United States) participated in these sessions as both learners and content experts. A questionnaire as well as comments suggested that the participants enjoyed the learning experience, which gave faculty, staff, and students opportunity to discuss in-depth educational issues related to process, content, and delivery of curricula.

  3. Nitrogen Assimilation in Escherichia coli: Putting Molecular Data into a Systems Perspective

    Science.gov (United States)

    van Heeswijk, Wally C.; Westerhoff, Hans V.

    2013-01-01

    SUMMARY We present a comprehensive overview of the hierarchical network of intracellular processes revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines transport, metabolism, signaling leading to posttranslational modification, and transcription. The protein components of the network include an ammonium transporter (AmtB), a glutamine transporter (GlnHPQ), two ammonium assimilation pathways (glutamine synthetase [GS]-glutamate synthase [glutamine 2-oxoglutarate amidotransferase {GOGAT}] and glutamate dehydrogenase [GDH]), the two bifunctional enzymes adenylyl transferase/adenylyl-removing enzyme (ATase) and uridylyl transferase/uridylyl-removing enzyme (UTase), the two trimeric signal transduction proteins (GlnB and GlnK), the two-component regulatory system composed of the histidine protein kinase nitrogen regulator II (NRII) and the response nitrogen regulator I (NRI), three global transcriptional regulators called nitrogen assimilation control (Nac) protein, leucine-responsive regulatory protein (Lrp), and cyclic AMP (cAMP) receptor protein (Crp), the glutaminases, and the nitrogen-phosphotransferase system. First, the structural and molecular knowledge on these proteins is reviewed. Thereafter, the activities of the components as they engage together in transport, metabolism, signal transduction, and transcription and their regulation are discussed. Next, old and new molecular data and physiological data are put into a common perspective on integral cellular functioning, especially with the aim of resolving counterintuitive or paradoxical processes featured in nitrogen assimilation. Finally, we articulate what still remains to be discovered and what general lessons can be learned from the vast amounts of data that are available now. PMID:24296575

  4. Ability to Cope with Pain Puts Migraine Surgery Patients in Perspective.

    Science.gov (United States)

    Gfrerer, Lisa; Lans, Jonathan; Faulkner, Heather R; Nota, Sjoerd; Bot, Arjan G J; Austen, William Gerald

    2018-01-01

    Candidates for migraine surgery are chronic pain patients with significant disability. Currently, migraine-specific questionnaires are used to evaluate these patients. Analysis tools widely used in evaluation of better understood pain conditions are not typically applied. This is the first study to include a commonly used pain questionnaire, the Pain Self-Efficacy Questionnaire (PSEQ) that is used to determine patients' pain coping abilities and function. It is an important predictor of pain intensity/disability in patients with musculoskeletal pain, as low scores have been associated with poor outcome. Ninety patients were enrolled prospectively and completed the Migraine Headache Index and PSEQ preoperatively and at 12 months postoperatively. Scores were evaluated using paired t tests and Pearson correlation. Representative PSEQ scores for other pain conditions were chosen for score comparison. All scores improved significantly from baseline (p migraine surgery was higher than seen in other pain conditions after treatment (112 percent). Preoperative PSEQ scores did not influence postoperative outcome. The PSEQ successfully demonstrates the extent of debility in migraine surgery patients by putting migraine pain in perspective with other known pain conditions. It further evaluates functional status, rather than improvement in migraine characteristics, which significantly adds to our understanding of outcome. Poor preoperative PSEQ scores do not influence outcome and should not be used to determine eligibility for migraine surgery. Therapeutic, IV.

  5. Will the Convention on Biological Diversity put an end to biological control?

    Directory of Open Access Journals (Sweden)

    Joop C. van Lenteren

    2011-03-01

    Full Text Available Will the Convention on Biological Diversity put an end to biological control? Under the Convention on Biological Diversity countries have sovereign rights over their genetic resources. Agreements governing the access to these resources and the sharing of the benefits arising from their use need to be established between involved parties. This also applies to species collected for potential use in biological control. Recent applications of access and benefit sharing principles have already made it difficult or impossible to collect and export natural enemies for biological control research in several countries. If such an approach is widely applied it would impede this very successful and environmentally safe pest management method based on the use of biological diversity. The International Organization for Biological Control of Noxious Animals and Plants has, therefore, created the "Commission on Biological Control and Access and Benefit Sharing". This commission is carrying out national and international activities to make clear how a benefit sharing regime might seriously frustrate the future of biological control. In addition, the IOBC Commission members published information on current regulations and perceptions concerning exploration for natural enemies and drafted some 30 case studies selected to illustrate a variety of points relevant to access and benefit sharing. In this article, we summarize our concern about the effects of access and benefit sharing systems on the future of biological control.

  6. Putting all your eggs in one basket: life-history strategies, bet hedging, and diversification.

    Science.gov (United States)

    White, Andrew Edward; Li, Yexin Jessica; Griskevicius, Vladas; Neuberg, Steven L; Kenrick, Douglas T

    2013-05-01

    Diversification of resources is a strategy found everywhere from the level of microorganisms to that of giant Wall Street investment firms. We examine the functional nature of diversification using life-history theory-a framework for understanding how organisms navigate resource-allocation trade-offs. This framework suggests that diversification may be adaptive or maladaptive depending on one's life-history strategy and that these differences should be observed under conditions of threat. In three studies, we found that cues of mortality threat interact with one index of life-history strategy, childhood socioeconomic status (SES), to affect diversification. Among those from low-SES backgrounds, mortality threat increased preferences for diversification. However, among those from high-SES backgrounds, mortality threat had the opposite effect, inclining people to put all their eggs in one basket. The same interaction pattern emerged with a potential biomarker of life-history strategy, oxidative stress. These findings highlight when, and for whom, different diversification strategies can be advantageous.

  7. Effect of preparation duration diminution in shot put through neurovegetative activity

    Directory of Open Access Journals (Sweden)

    A Dittmar

    2003-12-01

    Full Text Available Recently, time allocated to athletes concentration has been reduced to 1 minute. Increased activation and focused attention are thought to be important operations which influence performance during preparation. The aim of the study was to test whether reducing preparation time has an effect on subjects’ mental activity and consequently on performance. Ten subjects took part in the experiment. Each subject had to perform 14 throws: a 7 with preparation b 7 with no preparation. Autonomic nervous system activity was continuously recorded through six variables (2 electrodermal, 2 thermovascular and 2 cardiorespiratory variables. Performance was comparable in preparation and non-preparation modalities. Subjects increase their activation before throwing, however more rapidly without preparation time. Thus, performance was obtained through the same activation level whatever the time allocated to prepare. Shot-put performance seems to be dependent upon execution quality but also on reaching an optimal activation level. Phasic autonomic responses (related to focused attention and movement programming were recorded during preparation and execution. Only a weak relationship was evidenced between vegetative responses in preparation and execution phases. Thus, vegetative responses during the preparation phase did not attest mental operations such as focusing attention on a technical aspect.

  8. Putting people on the map through an approach that integrates social data in conservation planning.

    Science.gov (United States)

    Stephanson, Sheri L; Mascia, Michael B

    2014-10-01

    Conservation planning is integral to strategic and effective operations of conservation organizations. Drawing upon biological sciences, conservation planning has historically made limited use of social data. We offer an approach for integrating data on social well-being into conservation planning that captures and places into context the spatial patterns and trends in human needs and capacities. This hierarchical approach provides a nested framework for characterizing and mapping data on social well-being in 5 domains: economic well-being, health, political empowerment, education, and culture. These 5 domains each have multiple attributes; each attribute may be characterized by one or more indicators. Through existing or novel data that display spatial and temporal heterogeneity in social well-being, conservation scientists, planners, and decision makers may measure, benchmark, map, and integrate these data within conservation planning processes. Selecting indicators and integrating these data into conservation planning is an iterative, participatory process tailored to the local context and planning goals. Social well-being data complement biophysical and threat-oriented social data within conservation planning processes to inform decisions regarding where and how to conserve biodiversity, provide a structure for exploring socioecological relationships, and to foster adaptive management. Building upon existing conservation planning methods and insights from multiple disciplines, this approach to putting people on the map can readily merge with current planning practices to facilitate more rigorous decision making. © 2014 Society for Conservation Biology.

  9. Expression of the putA gene encoding proline dehydrogenase from Rhodobacter capsulatus is independent of NtrC regulation but requires an Lrp-like activator protein.

    Science.gov (United States)

    Keuntje, B; Masepohl, B; Klipp, W

    1995-11-01

    Four Rhodobacter capsulatus mutants unable to grow with proline as the sole nitrogen source were isolated by random Tn5 mutagenesis. The Tn5 insertions were mapped within two adjacent chromosomal EcoRI fragments. DNA sequence analysis of this region revealed three open reading frames designated selD, putR, and putA. The putA gene codes for a protein of 1,127 amino acid residues which is homologous to PutA of Salmonella typhimurium and Escherichia coli. The central part of R. capsulatus PutA showed homology to proline dehydrogenase of Saccharomyces cerevisiae (Put1) and Drosophila melanogaster (SlgA). The C-terminal part of PutA exhibited homology to Put2 (pyrroline-5-carboxylate dehydrogenase) of S. cerevisiae and to aldehyde dehydrogenases from different organisms. Therefore, it seems likely that in R. capsulatus, as in enteric bacteria, both enzymatic steps for proline degradation are catalyzed by a single polypeptide (PutA). The deduced amino acid sequence of PutR (154 amino acid residues) showed homology to the small regulatory proteins Lrp, BkdR, and AsnC. The putR gene, which is divergently transcribed from putA, is essential for proline utilization and codes for an activator of putA expression. The expression of putA was induced by proline and was not affected by ammonia or other amino acids. In addition, putA expression was autoregulated by PutA itself. Mutations in glnB, nifR1 (ntrC), and NifR4 (ntrA encoding sigma 54) had no influence on put gene expression. The open reading frame located downstream of R. capsulatus putR exhibited strong homology to the E. coli selD gene, which is involved in selenium metabolism. R. capsulatus selD mutants exhibited a Put+ phenotype, demonstrating that selD is required neither for viability nor for proline utilization.

  10. Prevalence of Dermatoses in Tribal Population of Kalrayan Hill (South Arcot District

    Directory of Open Access Journals (Sweden)

    C Mahalingam

    1986-01-01

    Full Text Available A sample survey was conducted to find out the prevalence of dermatoses among the tribal population of Kalrayan hill in South Arcot district who were recently found out .from the hidden spots of the hill. The prevalence of dermatoses was 40% among the 242 screened. Scabies had a prevalence of 22.7% and was more among the tribal s chool children put in huts, emphasizing the need for adequate shelter and health education. The low frequency of nutritional dermatoses 3.7% is attributed to the implementation of the noon-meal scheme. Surprising low prevalence rate for leprosy (1.7% in this highly endemic district of South Arcot needs further probing to find out some clues for protection from leprosy.

  11. [Monitoring the prevalence of obesity

    DEFF Research Database (Denmark)

    Sørensen, Thorkild I.A.; Due, P.; Hansen, B.

    2008-01-01

    The Danish Fitness and Nutrition Council has proposed a model to monitor the prevalence of overweight and obesity in Denmark. The model should make it possible to assess whether different initiatives reduce the prevalence of obesity and to gain knowledge on how to prevent obesity. The prevalence...

  12. Regulation of gene expression by repressor localization: biochemical evidence that membrane and DNA binding by the PutA protein are mutually exclusive.

    Science.gov (United States)

    Muro-Pastor, A M; Ostrovsky, P; Maloy, S

    1997-04-01

    The PutA protein from Salmonella typhimurium is a bifunctional enzyme that catalyzes the oxidation of proline to glutamate, a reaction that is coupled to the transfer of electrons to the electron transport chain in the cytoplasmic membrane. The PutA protein is also a transcriptional repressor that regulates the expression of the put operon in response to the availability of proline. Despite extensive genetic and biochemical studies of the PutA protein, it was not known if the PutA protein carries out both of these two opposing functions while membrane associated or if instead it carries them out in different cellular compartments. To distinguish between these alternatives, we directly assayed the binding of purified PutA protein to DNA and membranes in vitro. The results indicate that wild-type PutA does not simultaneously associate with DNA and membranes. In addition, PutA superrepressor mutants that exhibit increased repression of the put genes show a direct correlation between decreased membrane binding and increased DNA binding. These results support a model in which the PutA protein shuttles between the membrane (where it acts as an enzyme but lacks access to DNA-binding sites) and the cytoplasm (where it binds DNA and acts as a transcriptional repressor), depending on the availability of proline.

  13. Putting Muscle Into Sports Analytics: Strength, Conditioning, and Ice Hockey Performance.

    Science.gov (United States)

    Kniffin, Kevin M; Howley, Thomas; Bardreau, Cole

    2017-12-01

    Kniffin, KM, Howley, T, and Bardreau, C. Putting muscle into sports analytics: strength, conditioning, and ice hockey performance. J Strength Cond Res 31(12): 3253-3259, 2017-Sports analytics is best known as the field of research that focuses on discovering slight but significant improvements within competitions; however, broader sets of athlete- and team-level data from outside competitions (e.g., strength and conditioning metrics) have been typically left out from such analyses. Given that strength and conditioning programs are perhaps the most common avenue through which people expect extra-competition progress to translate into within-competition performance, it is clear that strength and conditioning metrics warrant closer analytic attention. To illustrate this approach, we present a study of National Collegiate Athletic Association (NCAA) Division 1 Men's Ice Hockey players that integrates both (a) strength and conditioning metrics and (b) in-game performance measurements. Bivariate analyses show a significant positive correlation between bench press performance and points scored (r = 0.15), although multivariate analyses point to positive relationships between strength and conditioning measures and playing time as the more important finding. Although within-competition data are increasingly accessible for analytics research, the basic approach that we develop highlights the importance of considering extra-competition variables such as strength and conditioning metrics for understanding both coaching decisions regarding playing time and within-competition performance. We also discuss ways in which the integrated approach that we present offers potential applications for strength and conditioning professionals as well as players, coaches, and team managers.

  14. Burying nuclear trash where it will stay put. Second of four articles

    International Nuclear Information System (INIS)

    Faltermayer, E.

    1979-01-01

    The issue of radioactive waste disposal threatening the growth of fission power is discussed. The challenge of burying such waste material has turned into an emotional debate by alarmists and it is feared that the government, which is responsible for waste disposal, may foul the job; e.g., the burial of wastes from atomic weapons programs has been postponed, and wastes have leaked into the ground from poorly designed temporary storage tanks. California, Maine, Wisconsin, and Iowa have imposed moratoria on new reactor starts until a satisfactory method of waste disposal has been demonstrated. The first demonstration of deep burial is scheduled for the mid- or late 1980s in a salt deposit near Carlsbad, New Mexico. The Federal government will then have to decide where to put permanent repositories, and 9 states have prohibited the burial of radioactive wastes within their borders. It takes centuries for radioactives wastes to decay, but they do decay. The industrial world routinely uses hundreds of dangerous materials (mercury, arsenic, etc.) that stay at full strength forever. These are usually dumped carelessly. Radioactive waste disposal will be far underground and sites carefully chosen. Some opponents of fission power agree that radioactive wastes can be interred safely. The only reason for hurrying a demonstration burial of reactor wastes is political. It would undercut the moratorium movement, and it will be at least 10 years before the results can be appraised. Various rock formations for storage have been assessed, with emphasis on the thick, flat beds of salt in Southwest US. Muchenergy remains in radioactive wastes, leading the author to say that burying fuel is foolish, since it may later have to be exhumed

  15. Putting the pieces together: teaching undergraduate research from a theoretical perspective.

    Science.gov (United States)

    Dobratz, Marjorie C

    2003-02-01

    PROBLEM/PURPOSE: Baccalaureate graduates are expected to utilize research across a wide variety of practice settings. While the literature reports a variety of teaching approaches, few studies examine baccalaureate students' comprehension of research content. Teaching techniques that focus on a conceptual or theoretical approach may foster research comprehension. Therefore, the purpose of this paper is to evaluate teaching/learning outcomes of an undergraduate nursing research course designed from a conceptual or theoretical approach. Two classes of senior baccalaureate nursing students (n = 47) at a private institution, whose curriculum was based on the Roy adaptation model, were surveyed in 1990 and 1991 at the end of their undergraduate research course. The survey tool consisted of seven three-point Likert scale questions, four open-ended questions, and one unstructured comment. Findings showed that 72% strongly agreed that they would continue to read nursing articles in their practice field, 57% disagreed that they were intimidated by research language, and 55% agreed that they trusted their ability to use and utilize nursing research in practice. The most helpful learning activity was the research critique (34%) followed by group work (28%). The support of the teacher and Instructor's use of own research examples was also seen as most helpful (36%), while abstract cards (8%) were least helpful. Nonetheless, 23% requested more group activities, 13% wanted more class examples, and 11% asked for more time to comprehend definitions. Students who approached research from the perspective of a nursing conceptual framework indicated that they put the pieces of the research puzzle together by working in groups, being supported by the Instructor, and learning from a variety of teaching methods.

  16. Premonitory Urge for Tics Scale (PUTS): replication and extension of psychometric properties in youth with chronic tic disorders (CTDs).

    Science.gov (United States)

    Raines, Jeremy M; Edwards, Kimberly R; Sherman, Martin F; Higginson, Christopher I; Winnick, Joel B; Navin, Kelly; Gettings, Julie M; Conteh, Fatmata; Bennett, Shannon M; Specht, Matthew W

    2018-04-01

    Individuals with chronic tic disorders (CTDs) frequently describe aversive subjective sensory sensations that precede their tics. The first aim of the present study was to explore the psychometric properties of a standardized self-report measure to assess premonitory urges in CTDs, The Premonitory Urge for Tics Scale (PUTS), by replicating the analyses of Woods et al. (J Dev Behav Pediatr 26:397-403, 2005) using a sample twice the size of theirs. The second aim was to conduct an exploratory factor analysis of the PUTS. Eighty-four youth with CTDs, recruited from a pediatric OCD and tic specialty clinic, completed the PUTS while their caregivers completed The Parent Tic Questionnaire (PTQ) and a demographic measure. Consistent with (Woods et al. J Dev Behav Pediatr 26:397-403, 2005), the PUTS was found to be internally consistent (α = 0.82) and significantly correlated with overall tic severity as measured by the PTQ (r = 0.24, p tics than the frequency or intensity of tics.

  17. Unwanted effects in aiming actions: The relationship between gaze behavior and performance in a golf putting task

    NARCIS (Netherlands)

    Binsch, O.; Oudejans, R.R.D.; Bakker, F.C.; Savelsbergh, G.J.P.

    2009-01-01

    Objectives Instructions to avoid an action may increase the tendency to engage in the action (ironic effects) or cause an undesirable increase in the opposing action (overcompensation). The aim of the study was to examine the relationship between gaze behavior and performance in a golf putting task

  18. Prevalence of Congenital Malformations

    Directory of Open Access Journals (Sweden)

    Akhavan Karbasi Sedighah

    2009-05-01

    Full Text Available Congenital malformation (CM will begin to emerge as one of the major childhood health problems .Treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. The aim of this study was to determine frequency of CM in Yazd central city of the Islamic Republic of Iran to find out if there has been any difference in the rate and types of CM in this area. This descriptive-observational study carried on 4800 births delivered at all maternity hospitals in Yazd from October 2003 to June 2004. Prevalence of CM was 2.83% (2.86 % in male and 2.68 % in female out of the 136 cases 69(51.88% were males and 64 (48.12% were females and 3 with ambiguous genitalia. Positive family history of CM in sibling was in only 6 cases (4.41%.Overall, musculoskeletal (0.83%, central nerv-ous system (0.47% and genital system (0.37% were accounted as the most common. Frequency of CM was more seen in still birth (12.5% as in comparison to live birth (2.71%. There was not statistical difference be-tween prevalence of CM and neonatal's gender, gestational age, birth order and mother's age, drug ingestion, illness and parental consanguinity. In this study the overall prevalence of congenital malformation among the newborn was higher than those previous reported in Iran and determining the causes of this difference needs more extensive studies.

  19. Prevalence of congenital amusia.

    Science.gov (United States)

    Peretz, Isabelle; Vuvan, Dominique T

    2017-05-01

    Congenital amusia (commonly known as tone deafness) is a lifelong musical disorder that affects 4% of the population according to a single estimate based on a single test from 1980. Here we present the first large-based measure of prevalence with a sample of 20 000 participants, which does not rely on self-referral. On the basis of three objective tests and a questionnaire, we show that (a) the prevalence of congenital amusia is only 1.5%, with slightly more females than males, unlike other developmental disorders where males often predominate; (b) self-disclosure is a reliable index of congenital amusia, which suggests that congenital amusia is hereditary, with 46% first-degree relatives similarly affected; (c) the deficit is not attenuated by musical training and (d) it emerges in relative isolation from other cognitive disorder, except for spatial orientation problems. Hence, we suggest that congenital amusia is likely to result from genetic variations that affect musical abilities specifically.

  20. The 'Kinderkrebs in der Umgebung von Kernkraftwerken' study: Results put into perspective

    International Nuclear Information System (INIS)

    Grosche, B.

    2008-01-01

    A German case-control study on leukaemia in children below 5 y of age near nuclear installations showed a trend of increasing risk with decreasing distance of place of residence from the sites. The radiation exposure from the sites is considered as being too low by a factor of at least 1000 to explain the observed effect, but little is known about radiation effects from pre- or postnatal exposures on the leukaemia risk for ages up to 4 y. Within the study, it was shown that the observed trend in risk decreases over time. That could be indicative of some agent being involved for which the prevalence is reduced over time. Previous ecological studies showed increased risks among the youngest age groups in the closest vicinity of the sites, but no elevated risks for children of all ages (0-14). This could implicate a shift towards an earlier onset of the disease. (authors)

  1. Put listening to the test: An aid to decision making in language placement

    Directory of Open Access Journals (Sweden)

    Marais, Fiona

    2010-12-01

    Full Text Available Universities and other higher education establishments throughout the world, including South Africa, have become concerned about the academic literacy levels of the students they enrol. The problem at most South African tertiary education institutions, which is in line with global trends, is certainly considerable, with almost a third of the students identified as being at risk. A lack of ability in academic discourse is seen as a major cause of students' failure to complete their courses within the given period. In 2006, as part of a nationwide attempt to remedy the academic literacy crisis, Stellenbosch University, along with other academic establishments, officially decided to implement a test of academic literacy in both English and Afrikaans. At Stellenbosch University, the English version of this test is known as TALL (Test of Academic Literacy Levels. It was developed to assess reading and writing abilities in an academic context. The results are used to ‘stream’ students into programmes which assist them in acquiring the various skills deemed necessary for their academic success. Students are sorted according to their TALL results into 'high risk' and 'low to no risk' categories, however, a need has been identified for further screening of the borderline students whose performance in the test falls between these two groups. Administrative and logistical limitations have, thus far, prevented listening skills from being included in the construct of TALL, but there is general consensus that listening is an important skill, particularly at university level. The focus of the research project, reported on in this article, was to design, and put into practice, an academic listening test (ALT to assist in decision making regarding the placement of first-year students in approved language courses at Stellenbosch University. The qualitative and quantitative results obtained from the various administrations of ALT were analysed to determine the

  2. Putting agricultural equipment and digital technologies at the cutting edge of agroecology

    Directory of Open Access Journals (Sweden)

    Bellon Maurel Véronique

    2017-05-01

    Full Text Available The agro-ecological transition is an ambitious challenge. It can be met by implementing the fundamentals of agroecology (use of biodiversity, integration of agriculture in landscapes, closure of flow loops in the context of a broad and renewed offer of technologies: agro-equipment, biotechnology, digital technologies… This article explores the role that agro-equipment and digital services can play in this transition. These technologies contribute through various levers to the agro-ecological transition: by improving farming efficiency (more service rendered for the same environmental impact, by precision farming (adaptation of the operations to the needs of the plant or the animal based on a monitoring–diagnosis–recommendation cycle and by the development of specialized machinery helping the farmer to achieve “flow loop-closing” (at the plot level, by maintaining the soil quality, or at the farm level, with the recycling of organic effluents or to take advantage of biodiversity (e.g., with agro-equipment adapted to mixed crops. The technological bricks that are requested and for which advances are expected are: sensors (to measure plant or animal needs and associated digital technologies (information transfer, data processing, precision technologies for input application, robotics, specialized machines to manage soil cover and weeds, or for agroforestry. The brakes and engines for innovation in agro-equipment are studied. The brakes are the generally small structure of the farm manufacturing companies, the deficit of the demand from farmers and the complexity − either real or perceived − of these equipments. To encourage innovation, several levers are to be used: involving users in the design of agro-equipments, creating financial incentives for innovative equipment purchase, and training end-users, prescribers and dealers to the high potential of these new technologies. In conclusion, putting agro-equipment and digital technology

  3. Regulatory region with putA gene of proline dehydrogenase that links to the lum and the lux operons in Photobacterium leiognathi.

    Science.gov (United States)

    Lin, J W; Yu, K Y; Chen, H Y; Weng, S F

    1996-02-27

    Nucleotide sequence of regulatory region (R & R) with putA gene (EMBL Accession No. U39227) from Photobacterium leiognathi PL741 has been determined, and the putA gene encoded amino acid sequence of proline dehydrogenase is deduced. Alignment and comparison of proline dehydrogenase of P. leiognathi with the proline dehydrogenase domain in the PutA protein of Escherichia coli and Salmonella typhimurium show that they are homologous. Nucleotide sequence reveals that regulatory region with the putA gene is linked to the lum and lux operons in genome; the gene order is putA--R & R(I) (R & R: regulatory region; ter:transcriptional terminator), whereas the R & R is the regulatory region for the lum and the lux operons, ter is the transcriptional terminator for the lum operon, and R & R(I) apparently is the regulatory region for the putA and related genes. Nucleotide sequence analysis illustrates the specific inverted repeat (SIR), cAMP-CRP consensus sequence, canonical -10/-35 promoter, putative operator and Shine-Dalgarno (SD) sequence on the regulatory region R & R(I) for the putA and related genes; it suggests that the putA and related genes are simply linked to the lum and the lux operons in genome, the regulatory region R & R(I) is independent for the putA and related genes.

  4. Competitive state anxiety and self-confidence: intensity and direction as relative predictors of performance on a golf putting task.

    Science.gov (United States)

    Chamberlain, Sean T; Hale, Bruce D

    2007-06-01

    This study considered relationships between the intensity and directional aspects of competitive state anxiety as measured by the modified Competitive Sport Anxiety Inventory-2(D) (Jones & Swain, 1992) in a sample of 12 experienced male golfers. Anxiety and performance scores from identical putting tasks performed under three different anxiety-manipulated competitive conditions were used to assess both the predictions of Multidimensional Anxiety Theory (MAT; Martens et al., 1990) and the relative value of intensity and direction in explaining performance variance. A within-subjects regression analysis of the intra-individual data showed partial support for the three MAT hypotheses. Cognitive anxiety intensity demonstrated a negative linear relationship with performance, somatic anxiety intensity showed a curvilinear relationship with performance, and self-confidence intensity revealed a positive linear relation. Cognitive directional anxiety illustrated a positive linear relationship with putting performance. Multiple regression analyses indicated that direction (42% of variance) was a better predictor of performance than intensity (22%).

  5. How a Guaranteed Annual Income Could Put Food Banks Out of Business

    Directory of Open Access Journals (Sweden)

    J.C. Herbert Emery

    2013-12-01

    the burden on the public health-care system. Canadian governments already spend billions of dollars on the downstream effects of poverty, but scant emphasis is put on programs targeting poverty’s roots. There is no evidence, where smaller-scale experiments have been tried, to show that a guaranteed income program creates a serious problem with negative incentives and discourages people from working who otherwise might. But because this is a common worry with working-age guaranteed income eligibility, phasing in the program gradually, by lowering eligibility a few years at a time, will allow ongoing investigation and analysis of the effects, before the program is rolled out on a large scale. The tremendous impact that guaranteed incomes have had on reducing poverty and improving health among seniors is something for which Canadians can be rightly proud. So much so that it is incumbent upon us to investigate whether Canada could use the same policy tools to drastically reduce poverty and improve health among Canadians of all ages.

  6. Unhealthy Pressure: How Physician Pay Demands Put the Squeeze on Provincial Health-Care Budgets

    Directory of Open Access Journals (Sweden)

    Hugh M. Grant

    2013-07-01

    were successful in holding back the growth in doctors’ fees, to the point where physicians saw their purchasing power shrink. If Canadians are now questioning where the priorities of doctors truly lie — whether its preserving health care or enriching themselves — the provinces can only gain more leverage in future negotiations with doctors. Physicians in the Canadian health-care system are entrusted with a special and protected role, and it behooves medical associations to bear in mind their additional responsibility to promote public health-care objectives. The current collective bargaining model has resulted in provinces pressured into buying healthcare peace by agreeing to continually ratchet up doctors’ pay. It is difficult to see how that can continue. It is time that doctors began working with policy-makers on a new model, one that puts less emphasis on profiting doctors, and more emphasis on promoting a sustainable health-care system for everyone.

  7. [Strabismus Sursoabductorius (put into the Context of eighteen Years of Strabismus Surgery Analysis)].

    Science.gov (United States)

    Krásný, J

    To familiarize with the form of combined horizontal and vertical deviations and its development and put it into the context of eighteen years of strabismus surgery analysis. During the period from 1996 to 2014, there were at the Department of Ophthalmology, 2nd Medical Faculty, Charles University and Faculty Hospital Královské Vinohrady, Prague, Czech Republic, E.U., operated on 2 248 patients due to the eye position misalignment. The surgery of dynamic (comitant) strabismus (esotropia, exotropia, vertical deviations and their combinations) was altogether performed in 81.7 % of patients. Out of them, horizontal-vertical deviations comprised 12.9 % - it was the strabismus sursoadductorius in 211 patients. Strabismus sursoabductorius (SAB) comprised 3.5 %; the initial type without excess of divergence (I-SAB) was established in 39 patients, and in other 43 patients it was the type already with the excess of divergence (E-SAB). The remaining surgeries were dealing with paralytic strabismus (14.7 %), and torticollis due to horizontal and torsional nystagmus (3.6 %). In the clinical picture of SAB dominated the elevation of the eyeball in abduction as well as in adduction, which was at the same time insufficient, negatively influencing the second phase of convergence. The divergent part of the deviation for far vision was on average in I-SAB 12 prisms (prism diopters)(), and in E-SAB 30 . The age of the patients at the time of the surgery was on average 12 years in I-SAB and 19.5 years in E-SAB. The difference between both evaluations was significant (p extorsion, but excluded incomitant relationship as well. This sursoabduction includes in itself some separate signs of dissociated vertical deviation (DVD), and adduction activity of overactioning inferior rectus muscle (IOOA), but does not represent either of these clinical entities. Recession of the inferior oblique muscle with its eventual simultaneous resection (anteposition) of the insertion at the level of

  8. Development Model of Basic Technique Skills Training Shot-Put Obrien Style Based Biomechanics Review

    Directory of Open Access Journals (Sweden)

    danang rohmat hidayanto

    2018-03-01

    Full Text Available The background of this research is the unavailability of learning model of basic technique technique of O'Brien style force that integrated in skill program based on biomechanics study which is used as a reference to build the basic technique skill of the O'Brien style force among students. The purpose of this study is to develop a model of basic-style technique of rejecting the O'Brien-style shot put based on biomechanical studies for beginner levels, including basic prefix technique, glide, final stage, repulsion, further motion and repulsion performance of O'Brien style, all of which arranged in a medium that is easily accessible whenever, by anyone and anywhere, especially in SMK Negeri 1 Kalijambe Sragen . The research method used is "Reasearch and Developement" approach. "Preliminary studies show that 43.0% of respondents considered that the O'Brien style was very important to be developed with a model of skill-based exercise based on biomechanics, as many as 40.0% ressponden stated that it is important to be developed with biomechanics based learning media. Therefore, it is deemed necessary to develop the learning media of the O'Brien style-based training skills based on biomechanical studies. Development of media starts from the design of the storyboard and script form that will be used as media. The design of this model is called the draft model. Draft models that have been prepared are reviewed by the multimedia expert and the O'Brien style expert to get the product's validity. A total of 78.24% of experts declare a viable product with some input. In small groups with n = 6, earned value 72.2% was obtained or valid enough to be tested in large groups. In the large group test with n = 12,values obtained 70.83% or quite feasible to be tested in the field. In the field test, experimental group was prepared with treatment according to media and control group with free treatment. From result of counting of significance test can be

  9. Putting politics into perspective. A Study of the Implementation of EU public utilities directives

    International Nuclear Information System (INIS)

    Berglund, S.K.

    2009-01-01

    , administrative, and legal character are of crucial importance for their effect. Such variables consequently cannot be ignored in an analysis of transposition. Applying implementation theory to transposition is a useful approach as it clarifies how a combination of variables affects transposition delay. The analysis is also relevant for three of the most prominent theoretical concepts put forward in the literature on transposition, namely the number of 'veto points' or 'veto players', 'misfit', and the 'worlds of compliance'. Regarding 'veto points', the current book shows that access to the process that does not involve a veto is also of key relevance, and that this access matters only in combination with other variables. It is also shown that while a high level of 'misfit' does lead to political resistance, the concept is too simplistic to be used directly as an explanatory variable. Finally, it is shown that a theoretical framework that combines different types of variables can serve as an alternative to dividing the member states into different 'worlds of compliance' in which different variables are of importance.

  10. Characterization of a Helicobacter hepaticus putA Mutant Strain in Host Colonization and Oxidative Stress ▿ †

    OpenAIRE

    Krishnan, Navasona; Doster, Alan R.; Duhamel, Gerald E.; Becker, Donald F.

    2008-01-01

    Helicobacter hepaticus is a gram-negative, spiral-shaped microaerophilic bacterium associated with chronic intestinal infection leading to hepatitis and colonic and hepatic carcinomas in susceptible strains of mice. In the closely related human pathogen Helicobacter pylori, l-proline is a preferred respiratory substrate and is found at significantly high levels in the gastric juice of infected patients. A previous study of the proline catabolic PutA flavoenzymes from H. pylori and H. hepaticu...

  11. On perpetual American put valuation and first-passage in a regime-switching model with jumps

    OpenAIRE

    Jiang, Z.; Pistorius, M. R.

    2008-01-01

    In this paper we consider the problem of pricing a perpetual American put option in an exponential regime-switching L\\'{e}vy model. For the case of the (dense) class of phase-type jumps and finitely many regimes we derive an explicit expression for the value function. The solution of the corresponding first passage problem under a state-dependent level rests on a path transformation and a new matrix Wiener-Hopf factorization result for this class of processes.

  12. EDTA sample contamination is common and often undetected, putting patients at unnecessary risk of harm.

    Science.gov (United States)

    Sharratt, C L; Gilbert, C J; Cornes, M C; Ford, C; Gama, R

    2009-08-01

    Potassium ethylenediaminetetraacetic acid (EDTA) is a sample tube anticoagulant used for many laboratory analyses. Gross potassium EDTA contamination of blood samples is easily recognised by marked hyperkalaemia and hypocalcaemia. However, subtle contamination is a relatively common, often unrecognised erroneous cause of spurious hyperkalaemia. Potassium EDTA contamination may also cause hypomagnesaemia and hypozincaemia. There are, however, no data on the prevalence of EDTA contamination as a cause of hypocalcaemia, hypomagnesaemia and hypozincaemia. Following a recent service evaluation, we measure EDTA in serum samples from patients with unexplained hyperkalaemia (serum potassium > 6.0 mmol/l). In addition, over a 1-month period EDTA concentrations were measured in hypocalcaemic (serum adjusted calcium samples. Ethylenediaminetetraacetic acid contamination was detected in 31 samples, nine of which were detected by our routine screening programme. The remaining 22 samples represented 14.3% (19/133) of hypocalcaemic samples, 4.8% (5/104) of hypomagnesaemic samples and 1.4% (2/139) of hypozincaemic samples. A total of 25/31 (80.6%) of patients were re-bled, of which 23/25 (92%) results normalised. Factitious hyperkalaemia, hypocalcaemia and hypomagnesaemia caused by potassium EDTA contamination in our studies are relatively common, and if unrecognised may adversely affect patient care and waste scarce healthcare resources. Correct order of draw of blood samples, improved education and routine laboratory screening of EDTA are necessary to prevent and identify EDTA contamination.

  13. IAEA puts cyber security in focus for nuclear facilities in 2015

    International Nuclear Information System (INIS)

    Shepherd, John

    2015-01-01

    Later in 2015 the International Atomic Energy Agency (IAEA) will convene a special conference to discuss computer security, in the wake of cyber attacks on global financial institutions and government agencies that were increasingly in the news. According to the IAEA, the prevalence of IT security incidents in recent years involving the Stuxnet malware 'demonstrated that nuclear facilities can be susceptible to cyber attack'. The IAEA said this and other events have significantly raised global concerns over potential vulnerabilities and the possibility of a cyber attack, or a joint cyber-physical attack, that could impact on nuclear security. The IAEA has correctly identified that the use of computers and other digital electronic equipment in physical protection systems at nuclear facilities, as well as in facility safety systems, instrumentation, information processing and communication, 'continues to grow and presents an ever more likely target for cyber attack'. The agency's Vienna conference, to be held in June, will review emerging trends in computer security and areas that may still need to be addressed. The meeting follows a declaration of ministers of IAEA member states in 2013 that called on the agency to help raise awareness of the growing threat of cyber attacks and their potential impact on nuclear security. The conference is being organised 'to foster international cooperation in computer security as an essential element of nuclear security', the IAEA said. Details of the IAEA's 'International Conference on Computer Security in a Nuclear World: Expert Discussion and Exchange' are on the 'meetings' section of the agency's web site.

  14. 12 CFR 220.128 - Treatment of simultaneous long and short positions in the same margin account when put or call...

    Science.gov (United States)

    2010-01-01

    ... positions in the same margin account when put or call options or combinations thereof on such stock are also...) Interpretations § 220.128 Treatment of simultaneous long and short positions in the same margin account when put...), if there are simultaneous long and short positions in the same security in the same margin account...

  15. IAEA puts cyber security in focus for nuclear facilities in 2015

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-01-15

    Later in 2015 the International Atomic Energy Agency (IAEA) will convene a special conference to discuss computer security, in the wake of cyber attacks on global financial institutions and government agencies that were increasingly in the news. According to the IAEA, the prevalence of IT security incidents in recent years involving the Stuxnet malware 'demonstrated that nuclear facilities can be susceptible to cyber attack'. The IAEA said this and other events have significantly raised global concerns over potential vulnerabilities and the possibility of a cyber attack, or a joint cyber-physical attack, that could impact on nuclear security. The IAEA has correctly identified that the use of computers and other digital electronic equipment in physical protection systems at nuclear facilities, as well as in facility safety systems, instrumentation, information processing and communication, 'continues to grow and presents an ever more likely target for cyber attack'. The agency's Vienna conference, to be held in June, will review emerging trends in computer security and areas that may still need to be addressed. The meeting follows a declaration of ministers of IAEA member states in 2013 that called on the agency to help raise awareness of the growing threat of cyber attacks and their potential impact on nuclear security. The conference is being organised 'to foster international cooperation in computer security as an essential element of nuclear security', the IAEA said. Details of the IAEA's 'International Conference on Computer Security in a Nuclear World: Expert Discussion and Exchange' are on the 'meetings' section of the agency's web site.

  16. Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources

    Science.gov (United States)

    Beeler, Jeff A.; Frazier, Cristianne R. M.; Zhuang, Xiaoxi

    2012-01-01

    . We propose that dopamine, by facilitating energy expenditure, should be protective against obesity. We suggest the apparent failure of this protective mechanism in Western societies with high prevalence of obesity arises as a consequence of sedentary lifestyles that thwart energy expenditure. PMID:22833718

  17. Putting Adolescents at Risk: Riding With Drinking Drivers Who Are Adults in the Home.

    Science.gov (United States)

    Harris, Sion K; Johnson, Julie K; Sherritt, Lon; Copelas, Sarah; Rappo, Melissa A; Wilson, Celeste R

    2017-01-01

    Alcohol-related car crashes are a leading cause of adolescent death, and one in five U.S. adolescents reports recent riding in a car with a drinking driver. How often the driver is an adult in the home (e.g., parent) is unknown. Pediatric visits offer an opportunity to counsel families to reduce this risk. Our study aim was to determine the prevalence of recent riding with a drinking driver (RWDD) who was an adult in the home among adolescent primary care patients and to identify the demographic and environmental (substance use among family members) profiles of those at increased risk. We recruited 12- to 18-year-olds arriving for routine medical care between 11/2005 and 10/2008 from nine practices in New England. Computer self-administered questionnaires assessed demographics, past-3-month RWDD, driver characteristics, and parent/sibling substance use. We computed adjusted relative risk ratios using multiple logistic regression modeling. Among 2,096 adolescents (86% participation rate; mean age = 15.8 years, SD = 2.0; 58% girls; 65% White non-Hispanic), 8.2% reported past-3-month RWDD who was an adult in the home (36.6% of those reporting any past-3-month RWDD). Risk was higher for girls, younger adolescents (<17 year olds), White non-Hispanic and Hispanic versus Black youth, those with non-college-graduate parents, and those with substance-involved parents. For a substantial proportion of adolescent primary care patients RWDD, the driver is a parent or other household adult, suggesting an important target for screening and counseling.

  18. Prevalence of schizophrenia: recent developments

    African Journals Online (AJOL)

    The long held view that schizophrenia affects about 1% of the population has been shown to be an overestimate and in fact derived from incorrect data.1 Also, for many years, it was believed that the prevalence of schizophrenia varied little between sites.2,3 It is in fact the case that the estimates of the prevalence of ...

  19. Prevalence of COPD in Copenhagen

    DEFF Research Database (Denmark)

    Fabricius, Peder; Løkke, Anders; Marott, Jacob Louis

    2011-01-01

    INTRODUCTION: COPD is a leading cause of death worldwide; however, prevalence estimates have varied considerably in previous studies. This study aimed to determine the prevalence and severity of COPD in Copenhagen using data from the 4th examination of The Copenhagen City Heart Study, to investig...

  20. Prevalence of COPD in Copenhagen

    DEFF Research Database (Denmark)

    Fabricius, Peder; Løkke, Anders; Marott, Jacob Louis

    2011-01-01

    COPD is a leading cause of death worldwide; however, prevalence estimates have varied considerably in previous studies. This study aimed to determine the prevalence and severity of COPD in Copenhagen using data from the 4th examination of The Copenhagen City Heart Study, to investigate...

  1. Prevalence of Food Additive Intolerance

    DEFF Research Database (Denmark)

    Madsen, Charlotte Bernhard

    1994-01-01

    1 The existing prevalence estimates of food additive intolerance(1-4) are being reviewed. 2 In the EEC report the estimated frequency of food additive intolerance is 0.03% to 0.15% based on data from patient groups. 3 The British population study results in a prevalence estimate of 0...... The prevalence estimates vary with a factor 100. As the results vary so do the study populations. 6 If the different study populations are accounted for, a common conclusion can be drawn: Food additive intolerance is found in adults with atopic symptoms from the respiratory tract and skin. The prevalence...... estimates are questionable but may be less than 0.15%. In adults and children with reproducible, and with more subjective symptoms, such as headache and behavioural/mood change the prevalence is even lower (0.026%). Food additive intolerance is primarily found in atopic children with cutaneous symptoms...

  2. How prevalent is 'food addiction'?

    Directory of Open Access Journals (Sweden)

    Adrian eMeule

    2011-11-01

    Full Text Available Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevalence of food addiction are rare. Few recent studies investigated addictive eating in children, adolescents, and adults. This mini-review presents these first attempts to assess addictive eating and how prevalent addictive eating patterns were in the respective studies. It is concluded that the prevalence of food addiction is increased in obese individuals and even more so in obese patients with binge eating disorder. However, prevalence of food addiction is not sufficient to account for the obesity epidemic. Conversely, an arguably high prevalence of food addiction can also be found in under-, normal-, and overweight individuals. Future studies may investigate which factors are associated with addictive eating in non-obese individuals.

  3. Prevalence of ataxia in children

    Science.gov (United States)

    Stoyanov, Cristina T.; Marasigan, Rhul; Jenkins, Mary E.; Konczak, Jürgen; Morton, Susanne M.; Bastian, Amy J.

    2014-01-01

    Objective: To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. Methods: A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measure (e.g., prevalence, incidence) of ataxia in children. Included articles were first grouped according to the World Health Organization (WHO) regions and subsequently classified according to etiology (genetic, acquired, or mixed). Each article was assessed for its risk of bias on the domains of sampling, measurement, and analysis. Incidence values were converted to prevalence estimates whenever possible. European prevalence estimates for different etiologies of ataxia were summed to gauge the overall prevalence of childhood ataxia. Results: One hundred fifteen articles were included in the review. More than 50% of the data originated from the Europe WHO region. Data from this region also showed the least susceptibility to bias. Little data were available for Africa and Southeast Asia. The prevalence of acquired ataxias was found to vary more greatly across regions than the genetic ataxias. Ataxic cerebral palsy was found to be a significant contributor to the overall prevalence of childhood ataxia across WHO regions. The prevalence of childhood ataxias in Europe was estimated to be ∼26/100,000 children and likely reflects a minimum prevalence worldwide. Conclusions: The findings show that ataxia is a common childhood motor disorder with a higher prevalence than previously assumed. More research concerning the epidemiology, assessment, and treatment of childhood ataxia is warranted. PMID:24285620

  4. Not just a pretty face: putting the learning into the Learning Commons

    Directory of Open Access Journals (Sweden)

    Rosie Jones

    2013-12-01

    Full Text Available The newly opened Alan Gilbert Learning Commons (AGLC provides a flexible learning space catering to students from across the University of Manchester With over 1000 study spaces, ranging from informal to formal, enclosed to open, complimented by state of the art innovative technology, the AGLC is an attractive central hub for students to visit anytime of the day and night. However, the Library's vision for the AGLC travels far beyond the physical space and seeks to engage with students at a much deeper level enhancing and developing their learning. To this end, the AGLC was a driver for the library to deliver its own unique training programme and open learning materials in support of the learning and development needs of all students, irrespective of academic discipline. This is achieved through collaboration and partnership between the current providers across campus, with the Learning Commons providing a central focus for a wide range of activity, to exemplify the best of what the University of Manchester can offer to enhance the student learning experience. This paper describes the development of the Learning Commons, from planning to launch, in particular highlighting how ‘the learning' was put into the learning commons. It will illustrate some of the ways in which the Learning Commons joins up existing and newly developed activity from across the campus to proactively encourage and support engagement with learning as well as providing a physical space that students really want to learn in. It will describe the current open training programme and this is now being developed further from a pedagogic perspective and through partnerships with other skills providers across the University to enhance the AGLC offer and to ensure effective integration of student skills provision. The Alan Gilbert Learning Commons (AGLC is the newest library service at the University of Manchester and opened in October 2012. The £24 million investment in the

  5. Expression, Purification and Characterization of the Proline Dehydrogenase Domain of PutA from Pseudomonas putida POS-F84.

    Science.gov (United States)

    Omidinia, Eskandar; Mahdizadehdehosta, Rahman; Mohammadi, Hamid Shahbaz

    2013-09-01

    The objective of the present work was to express a truncated form of Pseudomonas putida PutA that shows proline dehydrogenase (ProDH) activity. The putA gene encoding ProDH enzyme was cloned into pET23a vector and expressed in Escherichia coli strain BL-21 (DE3) plysS. The recombinant P. putida enzyme was biochemically characterized and its three dimensional structure was also predicted. ProDH encoding sequence showed an open reading frame of 1,035-bp encoding a 345 amino acid residues polypeptide chain. Purified His-tagged enzyme gave a single band with a molecular mass of 40 kDa on SDS-PAGE. The molecular mass of the isolated enzyme was found to be about 40 kDa by gel filtration. This suggested that the enzyme of interest consists of one subunit. The K m and V max values of recombinant P. putida ProDH were estimated to be 31 mM and 132 μmol/min, respectively. The optimum pH and temperature for the catalytic activity of the enzyme was about pH 8.5 and 30 °C. The modeling analysis of the three dimensional structure elucidated that Ser-165, Lys-195 and Ala-252 were key residues for the ProDH activity. This study provides data on the cloning, sequencing and recombinant expression of PutA ProDH domain from P. putida POS-F84.

  6. Pricing of American Put Option under a Jump Diffusion Process with Stochastic Volatility in an Incomplete Market

    Directory of Open Access Journals (Sweden)

    Shuang Li

    2014-01-01

    Full Text Available We study the pricing of American options in an incomplete market in which the dynamics of the underlying risky asset is driven by a jump diffusion process with stochastic volatility. By employing a risk-minimization criterion, we obtain the Radon-Nikodym derivative for the minimal martingale measure and consequently a linear complementarity problem (LCP for American option price. An iterative method is then established to solve the LCP problem for American put option price. Our numerical results show that the model and numerical scheme are robust in capturing the feature of incomplete finance market, particularly the influence of market volatility on the price of American options.

  7. Hepatitis B prevalence in Denmark

    DEFF Research Database (Denmark)

    Hansen, N; Hay, G; Cowan, S

    2013-01-01

    The prevalence of chronic hepatitis B virus (HBV) infection in Denmark is not clear. The primary aim of this study was to estimate the prevalence of chronic HBV infection in Denmark. The capture–recapture method was used to estimate the total population diagnosed with chronic HBV infection...... in Denmark using four nationwide registers. The population with undiagnosed chronic HBV infection was estimated by incorporating data from a two-year nationwide HBsAg screening programme in pregnant women. We identified 4,466 individuals with chronic HBV infection in the four registers until the end of 2007...... alive with HBV infection was 10,668 (95% CI: 10,224–16,164), corresponding to a prevalence of 0.24% (95% CI: 0.23–0.37%) in the Danish population older than 15 years. The estimated prevalence of chronic HBV infection among adults in Denmark was lower than reported from other northern European countries...

  8. Prevalence of Food Additive Intolerance

    DEFF Research Database (Denmark)

    Madsen, Charlotte Bernhard

    1994-01-01

    estimates are questionable but may be less than 0.15%. In adults and children with reproducible, and with more subjective symptoms, such as headache and behavioural/mood change the prevalence is even lower (0.026%). Food additive intolerance is primarily found in atopic children with cutaneous symptoms......1 The existing prevalence estimates of food additive intolerance(1-4) are being reviewed. 2 In the EEC report the estimated frequency of food additive intolerance is 0.03% to 0.15% based on data from patient groups. 3 The British population study results in a prevalence estimate of 0.......026%. The challenged population is 81 children and adults with a history of reproducible clinical symptoms after ingestion of food additives. 4 In the Danish population study a prevalence of 1-2% is found in children age 5-16. In this study a total of 606 children mainly with atopic disease have been challenged. 5...

  9. Prevalence of COPD in Copenhagen

    DEFF Research Database (Denmark)

    Fabricius, Peder; Løkke, Anders; Marott, Jacob Louis

    2011-01-01

    COPD is a leading cause of death worldwide; however, prevalence estimates have varied considerably in previous studies. This study aimed to determine the prevalence and severity of COPD in Copenhagen using data from the 4th examination of The Copenhagen City Heart Study, to investigate...... the relationship between tobacco consumption and COPD, and to characterize the subjects with COPD with regard to BMI, dyspnoea, treatment with respiratory medication and co-morbidities....

  10. Prevalence and pattern of asymptomatic bacteriuria among ...

    African Journals Online (AJOL)

    Most of the cultured organism (89%) were sensitive to Nitrofurantoin. Conclusion: The prevalence of asymptomatic bacteriuria among pregnant women at the UPTH is high. The most prevalent organism was Klebsiella. Keywords: Asymptomatic bacteriuria, Prevalence, Pattern, Klebsiella, Nitrofurantion, Morbidity ...

  11. Effects of subsurface aeration and trinexapac-ethyl application on soil microbial communities in a creeping bentgrass putting green

    Science.gov (United States)

    Feng, Y.; Stoeckel, D.M.; Van Santen, E.; Walker, R.H.

    2002-01-01

    The sensitivity of creeping bentgrass (Agrostis palustris Huds.) to the extreme heat found in the southeastern United States has led to the development of new greens-management methods. The purpose of this study was to examine the effects of subsurface aeration and growth regulator applications on soil microbial communities and mycorrhizal colonization rates in a creeping bentgrass putting green. Two cultivars (Crenshaw and Penncross), a growth regulator (trinexapacethyl), and subsurface aeration were evaluated in cool and warm seasons. Total bacterial counts were higher in whole (unsieved) soils than in sieved soils, indicating a richer rhizosphere soil environment. Mycorrhizal infection rates were higher in trinexapac-ethyl (TE) treated plants. High levels of hyphal colonization and relatively low arbuscule and vesicle occurrence were observed. Principal components analysis of whole-soil fatty acid methyl ester (FAME) profiles indicated that warm-season microbial populations in whole and sieved soils had similar constituents, but the populations differed in the cool season. FAME profiles did not indicate that subsurface aeration and TE application affected soil microbial community structure. This is the first reported study investigating the influences of subsurface aeration and TE application on soil microorganisms in a turfgrass putting green soil.

  12. Proposal of thinking process model based on putting a question to oneself for problem solving by skilled engineers

    International Nuclear Information System (INIS)

    Fukumoto, Toshihiko; Kishi, Yoshiki

    2007-01-01

    The retirement of the skilled engineers and researchers, who have been working in the field of water chemistry of BWRs since the establishment of Japanese BWRs, has been accelerating so that it is necessary to preserve and share the knowledge and know-how of these skilled engineers and to effectively and securely inherit them to the following generations. Moreover, in order for other engineers to share knowledge, including the tacit knowledge of a skilled engineer, it is necessary not only to understand the knowledge obtained as the results of the thinking of the skilled engineers but also to externalize and experience their thinking processes as the processes of problem solving that produced the results. The target of this research is to build a new thinking process model that can externalize thinking processes effectively by analyzing the knowledge and thinking contents of the skilled engineers for investigating causes of changes in the quality of reactor water in boiling water reactor type power plants. As part of this research, we found out a new metacognitive activity, Putting a Question to Oneself, which plays a large role in the thinking process structure. In addition, we developed a new fundamental thinking process model, which can externalize thinking processes effectively by integrating the concept of Putting a Question to Oneself into the thinking process model. (author)

  13. EFFECT OF TRAINING INFORMATION TECHNOLOGY AND COMMUNICATION DRIVING SCHOOL Case of the teaching of O'Brien shot put style

    Directory of Open Access Journals (Sweden)

    Aymen Hawani

    2015-04-01

    Full Text Available The purpose of this study was to compare three different pedagogical approaches to training of complex motor skill: shot put style translation (O'Brien. The first is to introduce learning situations using an 'Audiovisual Projection' '(APA. The second is essentially based on demonstration of gesture, supported by verbal instructions (ADG. The third is based exclusively on verbal instructions (ACV. To do this, a group of 87 trainees from three classes of 7th base year participated in this study. Their average age was between 12 and 14 years, an average height of about ± 1.60m and a weight of 55 kg ±. All they had no practical experience in athletic activity, specifically in Shot Put. To each of three classes one of the three approaches was applied as well as 8 sessions alternating with three assessment sessions. The results showed that performance of trainees after using of the first approach (APA was relatively better than that was achieved with using of other two approaches, especially when training of complex motor tasks, specific to the chosen style of throwing. This allows to deduce the existence of a relationship between complexity of the motor action to be reproduce and interpretation of audiovisual messages, presented by the coach in the middle of training cycle.

  14. EFFECT OF TRAINING INFORMATION TECHNOLOGY AND COMMUNICATION DRIVING SCHOOL Case of the teaching of O'Brien shot put style

    Directory of Open Access Journals (Sweden)

    Hawani Aymen

    2015-05-01

    Full Text Available The purpose of this study was to compare three different pedagogical approaches to training of complex motor skill: shot put style translation (O'Brien. The first is to introduce learning situations using an 'Audiovisual Projection' '(APA. The second is essentially based on demonstration of gesture, supported by verbal instructions (ADG. The third is based exclusively on verbal instructions (ACV. To do this, a group of 87 trainees from three classes of 7th base year participated in this study. Their average age was between 12 and 14 years, an average height of about ± 1.60m and a weight of 55 kg ±. All they had no practical experience in athletic activity, specifically in Shot Put. To each of three classes one of the three approaches was applied as well as 8 sessions alternating with three assessment sessions. The results showed that performance of trainees after using of the first approach (APA was relatively better than that was achieved with using of other two approaches, especially when training of complex motor tasks, specific to the chosen style of throwing. This allows to deduce the existence of a relationship between complexity of the motor action to be reproduce and interpretation of audiovisual messages, presented by the coach in the middle of training cycle.

  15. Workplace violence towards nurses in Hong Kong: prevalence and correlates.

    Science.gov (United States)

    Cheung, Teris; Yip, Paul S F

    2017-02-14

    Nurses are especially vulnerable to violent and other forms of aggression in the workplace. Nonetheless, few population-based studies of workplace violence have been undertaken among working-age nurse professionals in Hong Kong in the last decade. The study estimates the prevalence and examines the socio-economic and psychological correlates of workplace violence (WPV) among professional nurses in Hong Kong. The study uses a cross-sectional survey design. Multivariate logistic regression examines the weighted prevalence rates of WPV and its associated factors for a population of nurses. A total of 850 nurses participated in the study. 44.6% had experienced WPV in the preceding year. Male nurses reported more WPV than their female counterparts. The most common forms of WPV were verbal abuse/bullying (39.2%), then physical assault (22.7%) and sexual harassment (1.1%). The most common perpetrators of WPV were patients (36.6%) and their relatives (17.5%), followed by colleagues (7.7%) and supervisors (6.3%). Clinical position, shift work, job satisfaction, recent disturbances with colleagues, deliberate self-harm (DSH) and symptoms of anxiety were significantly correlated with WPV for nurses. WPV remains a significant concern for healthcare worldwide. Hong Kong's local health authority should put in place a raft of zero-tolerance measures to prevent WPV in healthcare settings.

  16. Workplace violence towards nurses in Hong Kong: prevalence and correlates

    Directory of Open Access Journals (Sweden)

    Teris Cheung

    2017-02-01

    Full Text Available Abstract Background Nurses are especially vulnerable to violent and other forms of aggression in the workplace. Nonetheless, few population-based studies of workplace violence have been undertaken among working-age nurse professionals in Hong Kong in the last decade. Methods The study estimates the prevalence and examines the socio-economic and psychological correlates of workplace violence (WPV among professional nurses in Hong Kong. The study uses a cross-sectional survey design. Multivariate logistic regression examines the weighted prevalence rates of WPV and its associated factors for a population of nurses. Results A total of 850 nurses participated in the study. 44.6% had experienced WPV in the preceding year. Male nurses reported more WPV than their female counterparts. The most common forms of WPV were verbal abuse/bullying (39.2%, then physical assault (22.7% and sexual harassment (1.1%. The most common perpetrators of WPV were patients (36.6% and their relatives (17.5%, followed by colleagues (7.7% and supervisors (6.3%. Clinical position, shift work, job satisfaction, recent disturbances with colleagues, deliberate self-harm (DSH and symptoms of anxiety were significantly correlated with WPV for nurses. Conclusions WPV remains a significant concern for healthcare worldwide. Hong Kong’s local health authority should put in place a raft of zero-tolerance measures to prevent WPV in healthcare settings.

  17. Redox induced changes in flavin structure and the roles of the flavin N(5) and ribityl 2′-OH in regulating PutA-membrane binding†

    Science.gov (United States)

    Zhang, Weimin; Zhang, Min; Zhu, Weidong; Zhou, Yuzhen; Wanduragala, Srimevan; Rewinkel, Dustin; Tanner, John J.; Becker, Donald F.

    2008-01-01

    PutA is a novel flavoprotein in Escherichia coli that switches from a transcriptional repressor to a membrane-bound proline catabolic enzyme. Previous crystallographic studies of the PutA proline dehydrogenase (PRODH) domain under oxidizing conditions revealed that the FAD N(5) and ribityl 2′- OH form hydrogen bonds with Arg431 and Arg556, respectively. Here we identify molecular interactions in the PutA PRODH active site that underlie redox-dependent functional switching of PutA. We report that reduction of the PRODH domain induces major structural changes in the FAD cofactor, including a 22° bend of the isoalloxazine ring along the N(5)-N(10) axis, crankshaft rotation of the upper part of the ribityl chain, and formation of a new hydrogen bond network involving the ribityl 2′- OH, FAD N(1) atom, and Gly435. The roles of the FAD 2′-OH group and the FAD N(5)-Arg431 hydrogen bond pair in regulating redox-dependent PutA-membrane associations were tested using FAD analogues and site-directed mutagenesis. Kinetic membrane-binding measurements and cell-based reporter gene assays of modified PutA proteins show that disrupting the FAD N(5)-Arg431 interaction impairs reductive activation of PutA-membrane binding. We also show that the FAD-2′-OH acts as a redox-sensitive toggle switch that controls PutA-membrane binding. These results illustrate a new versatility of the ribityl chain in flavoprotein mechanisms. PMID:17209558

  18. Redox-induced changes in flavin structure and roles of flavin N(5) and the ribityl 2'-OH group in regulating PutA--membrane binding.

    Science.gov (United States)

    Zhang, Weimin; Zhang, Min; Zhu, Weidong; Zhou, Yuzhen; Wanduragala, Srimevan; Rewinkel, Dustin; Tanner, John J; Becker, Donald F

    2007-01-16

    PutA is a novel flavoprotein in Escherichia coli that switches from a transcriptional repressor to a membrane-bound proline catabolic enzyme. Previous crystallographic studies of the PutA proline dehydrogenase (PRODH) domain under oxidizing conditions revealed that FAD N(5) and the ribityl 2'-OH group form hydrogen bonds with Arg431 and Arg556, respectively. Here we identify molecular interactions in the PutA PRODH active site that underlie redox-dependent functional switching of PutA. We report that reduction of the PRODH domain induces major structural changes in the FAD cofactor, including a 22 degrees bend of the isoalloxazine ring along the N(5)-N(10) axis, crankshaft rotation of the upper part of the ribityl chain, and formation of a new hydrogen bond network involving the ribityl 2'-OH group, FAD N(1), and Gly435. The roles of the FAD 2'-OH group and the FAD N(5)-Arg431 hydrogen bond pair in regulating redox-dependent PutA-membrane associations were tested using FAD analogues and site-directed mutagenesis. Kinetic membrane binding measurements and cell-based reporter gene assays of modified PutA proteins show that disrupting the FAD N(5)-Arg431 interaction impairs the reductive activation of PutA-membrane binding. We also show that the FAD 2'-OH group acts as a redox-sensitive toggle switch that controls PutA-membrane binding. These results illustrate a new versatility of the ribityl chain in flavoprotein mechanisms.

  19. Urbanization and prevalence of type 2 diabetes in Southern Asia: A systematic analysis

    Science.gov (United States)

    Cheema, Arsalan; Adeloye, Davies; Sidhu, Simrita; Sridhar, Devi; Chan, Kit Yee

    2014-01-01

    Background Diabetes mellitus is one of the diseases considered to be the main constituents of the global non–communicable disease (NCD) pandemic. Despite the large impact that NCDs are predicted to have, particularly in developing countries, estimates of disease burden are sparse and inconsistent. This systematic review transparently estimates prevalence of type 2 diabetes mellitus in Southern Asia, its association with urbanization and provides insight into the policy challenges facing the region. Methods The databases Medline and PubMed were searched for population–based studies providing estimates of diabetes prevalence in the Southern Asia region. Studies using WHO diagnostic criteria of fasting plasma glucose (FPG) ≥7.0mmol/L and/or 2h–plasma glucose (2hPG) ≥11.1mmol/L were included. Data from eligible studies was extracted into bubble graphs, and trend lines were applied to UNPD figures to estimate age–specific prevalence in the regional population. Estimates specific to sex, area of residency, and diagnostic method were compared and trends analysed. Results A total of 151 age–specific prevalence estimates were extracted from 39 studies. Diabetes prevalence was estimated to be 7.47% for 2005 and 7.60% for 2010. Prevalence was strongly associated with increased age, male gender and urban residency (P Diabetes prevalence in Southern Asia is high and predicted to increase in the future as life expectancy rises and the region continues to urbanise. Countries in this region need to improve NCD surveillance and monitoring so policies can be informed with the best evidence. Programs for prevention need to be put in place, and health system capacity and access needs to be assessed and increased to deal with the predicted rise in NCD prevalence. PMID:24976963

  20. Prevalence of Listeria monocytogenes in raw bovine milk and milk products from central highlands of Ethiopia.

    Science.gov (United States)

    Seyoum, Eyasu Tigabu; Woldetsadik, Daniel Asrat; Mekonen, Tesfu Kassa; Gezahegn, Haile Alemayehu; Gebreyes, Wondwossen Abebe

    2015-11-30

    Listeria monocytogenes is of major significance in human and veterinary medicine. Most human Listeria infections are foodborne and the association of contaminated milk and dairy produce consumption with human listeriosis is noteworthy. In Ethiopia, there is limited data regarding the prevalence of L. monocytogenes in raw bovine milk and dairy products. The aim of this study was, therefore, to determine the prevalence of L. monocytogenes in raw bovine milk and dairy produce. A total of 443 milk and milk product samples were microbiologically analyzed following methods recommended by the U.S. Food and Drug Administration Bacteriological Analytical Manual to isolate Listeria spp. The overall prevalence of Listeria spp. was 28.4% and specifically that of L. monocytogenes was 5.6%. Taking the prevalence of Listeria spp. into consideration, cheese was found to be highly contaminated at 60%, followed by pasteurized milk samples (40%), raw milk (18.9%) and yoghurt (5%). Considering the prevalence of Listeria monocytogenes only, raw milk had the lowest contamination while cheese had the highest, followed by pasteurized milk and yoghurt. Raw milk and milk products produced in urban and peri-urban areas of central Ethiopia were contaminated with pathogenic bacteria, L. monocytogenes. The detection of this pathogen in raw milk and milk products warrants an urgent regulatory mechanism to be put in place and also the potential role of milk processing plants in the contamination of dairy products should be investigated.

  1. Prevalence of microcephaly in Europe

    DEFF Research Database (Denmark)

    Morris, Joan K; Rankin, Judith; Garne, Ester

    2016-01-01

    OBJECTIVES: To provide contemporary estimates of the prevalence of microcephaly in Europe, determine if the diagnosis of microcephaly is consistent across Europe, and evaluate whether changes in prevalence would be detected using the current European surveillance performed by EUROCAT (the European...... Surveillance of Congenital Anomalies). DESIGN: Questionnaire and population based observational study. SETTING: 24 EUROCAT registries covering 570 000 births annually in 15 countries. PARTICIPANTS: Cases of microcephaly not associated with a genetic condition among live births, fetal deaths from 20 weeks......' gestation, and terminations of pregnancy for fetal anomaly at any gestation. MAIN OUTCOME MEASURES: Prevalence of microcephaly (1 Jan 2003-31 Dec 2012) analysed with random effects Poisson regression models to account for heterogeneity across registries. RESULTS: 16 registries responded to the questionnaire...

  2. The prevalence of sick leave

    DEFF Research Database (Denmark)

    Backhausen, Mette; Damm, Peter; Bendix, Jane

    2018-01-01

    Objective We aimed to investigate the prevalence of sick leave and self-reported reasons given for sick leave during pregnancy. Furthermore, we aimed to estimate the frequency of long-term sick leave during pregnancy in relation to pre-baseline maternal characteristics and to identify predictors...... on sick leave and the associated reasons. Descriptive statistics and logistic regression analysis were applied. Results The prevalence of sick leave was 56% of employed pregnant women in the first 32 weeks of gestation and more than one in four reported long-term sick leave (>20 days, continuous...... was a negative predictor. Conclusions The prevalence of sick leave was 56% in the first 32 weeks of gestation and more than one in four women reported long-term sick leave. The majority of reasons for sick leave were pregnancy-related and low back pain was the most frequently given reason....

  3. Airport baggage handling--where do human factors fit in the challenges that airports put on a baggage system?

    Science.gov (United States)

    Lenior, O N M

    2012-01-01

    The challenges put on large baggage systems by airports can be summarized as: handling a high number of bags in a short period of time, in a limited space, with all sorts of disruptions, whilst complying with stringent regulation upon security, sustainability and health and safety. The aim of this company case study is to show in the different project phases--as indicated in the system ergonomic approach--how the human factors specialist can play a major part in tackling these challenges. By describing different projects in terms of scope, organization, human factors topics covered, phases and lessons learned, the importance of Human-Computer Interaction, automation as well as manual handling and work organization in baggage is addressed.

  4. Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate*

    Science.gov (United States)

    Knihtila, Ryan; Holzapfel, Genevieve; Weiss, Kevin; Meilleur, Flora; Mattos, Carla

    2015-01-01

    RAS GTPase is a prototype for nucleotide-binding proteins that function by cycling between GTP and GDP, with hydrogen atoms playing an important role in the GTP hydrolysis mechanism. It is one of the most well studied proteins in the superfamily of small GTPases, which has representatives in a wide range of cellular functions. These proteins share a GTP-binding pocket with highly conserved motifs that promote hydrolysis to GDP. The neutron crystal structure of RAS presented here strongly supports a protonated γ-phosphate at physiological pH. This counters the notion that the phosphate groups of GTP are fully deprotonated at the start of the hydrolysis reaction, which has colored the interpretation of experimental and computational data in studies of the hydrolysis mechanism. The neutron crystal structure presented here puts in question our understanding of the pre-catalytic state associated with the hydrolysis reaction central to the function of RAS and other GTPases. PMID:26515069

  5. Putting Out Fires: Understanding the Developmental Nature and Roles of Inmate Gangs in the Philippine Overcrowded Jails.

    Science.gov (United States)

    Narag, Raymund E; Lee, Sou

    2017-12-01

    Utilizing intensive interview data from inmates in one of the most overcrowded and underresourced jails in Metro Manila, Philippines, this article explores the origins and roles of inmate pangkats (a derivative of gangs) in jail management. Responding to institutional deficiencies, such as police misconduct and court case delays, and structural shortages, such as lack of space, operational resources, and personnel, this article investigates how the pangkats supplement jail management and help keep the jail operations afloat. Specifically, this article documents how the pangkats put out fires: their intricate roles in mitigating pains of imprisonment, conflict mediation, order maintenance, and instilling discipline among their members. This article also details the emergence of a give-and-take relationship that develops between and among the pangkats and jail officials that are reflective of the Philippine sociocultural realities. Implications to theory on prison community and policy on gang management in a developing country context are discussed.

  6. Some particular problems put by operating experimental reactors; Quelques problemes particuliers poses par le fonctionnement des piles laboratoires

    Energy Technology Data Exchange (ETDEWEB)

    Candiotti, C.; Mabeix, R.; Uguen, R. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [French] Les redacteurs se basant sur six annees d'experience dans l'exploitation de reacteurs de recherche, exposent tout d'abord les differences d'utilisation entre ces engins et d'autres appareils fonctionnellement similaires et font ressortir, par voie de consequence, les servitudes correspondantes. Ces servitudes posent des problemes tres particuliers dans les domaines de l'exploitation proprement dite, de l'entretien, des modifications ou adjonctions apportees a l'ensemble. (auteur)

  7. Identification and Pathogenicity of Bacteria Associated with Etiolation and Decline of Creeping Bentgrass Golf Course Putting Greens.

    Science.gov (United States)

    Roberts, Joseph A; Ma, Bangya; Tredway, Lane P; Ritchie, David F; Kerns, James P

    2018-01-01

    Bacterial etiolation and decline has developed into a widespread issue with creeping bentgrass (CBG) (Agrostis stolonifera) putting green turf. The condition is characterized by an abnormal elongation of turfgrass stems and leaves that in rare cases progresses into a rapid and widespread necrosis and decline. Recent reports have cited bacteria, Acidovorax avenae and Xanthomonas translucens, as causal agents; however, few cases exist where either bacterium were isolated in conjunction with turf exhibiting bacterial disease symptoms. From 2010 to 2014, turfgrass from 62 locations submitted to the NC State Turf Diagnostic Clinic exhibiting bacterial etiolation and/or decline symptoms were sampled for the presence of bacterial pathogens. Isolated bacteria were identified using rRNA sequencing of the 16S subunit and internal transcribed spacer region (16S-23S or ITS). Results showed diverse bacteria isolated from symptomatic turf and A. avenae and X. translucens were only isolated in 26% of samples. Frequently isolated bacterial species were examined for pathogenicity to 4-week-old 'G2' CBG seedlings and 8-week-old 'A-1' CBG turfgrass stands in the greenhouse. While results confirmed pathogenicity of A. avenae and X. translucens, Pantoea ananatis was also shown to infect CBG turf; although pathogenicity varied among isolated strains. These results illustrate that multiple bacteria are associated with bacterial disease and shed new light on culturable bacteria living in CBG turfgrass putting greens. Future research to evaluate additional microorganisms (i.e., bacteria and fungi) could provide new information on host-microbe interactions and possibly develop ideas for management tactics to reduce turfgrass pests.

  8. Optimizing Search Patterns for Multiple Searchers Prosecuting a Single Contact In the South China Sea

    Science.gov (United States)

    2016-09-01

    detected, the event is recorded, and that particular run is terminated . Thismeans that over time, the number of runs decreases. Over time, the detection...of the two factors were large enough, the results converged to a probability of detection of 1, and this fact is noted by a vertical line terminating ...Applying the math that sank U-boats to today’s intel problems. Defense News. [Online]. Available: http: //www.defensenews.com/article/20130705

  9. 4-10 December's Young searchers' meeting days

    International Nuclear Information System (INIS)

    Besse, Adrien; Abdel Khalek, Samah; Basara, Laurent; Schwoerer, Maud; Bernard, Guilhem; Martin-Burtart, Nicolas; Bouhou, Boutayeb; Zidi, Mohamed Sadok; Cellier-Holzem, Flora; Sanselme, Lilian; Leong, Lou Sai; Bonnand, Romain; Sounalet, Thomas; Marchand, Benoit; David, Sabes; Coste, Benoit; Dbeyssi, Alaa; Bertella, Claudia; Biteau, Jonathan; Zabi, Alexandre; Ponthieu, Nicolas; Heller, Matthieu; Hadjidakis, Cynthia; Chabod, Sebastien; Valencia Palomo, Lizardo; Bernat, Pauline; Da Silva, Jonathan; Louedec, Karim; Roa Romero, Diego Alejandro; Amouroux, Charlotte; Tartare, Mathieu; Daci, Nadir; Nguyen, Chi Linh; Espitalier, Gregory; Guilbaud, Maxime; Barrillon, Pierre; Khelifi, Bruno; Chabert, Eric; Clement, Emmanuel; Bongard, Sebastien; Ferrero, Andrea; Cossin, Isabelle; Torres Machado, Diego; Blondel, Sophie; Beaupere, Nicolas; Akar, Simon; Teinturier, Marthe; Davignon, Olivier; Paredes, Daniela; Hurier, Guillaume; Zambelli, Laura; Martin Sanchez, Alexandra; Rigault, Mickael

    2011-12-01

    This publication gathers 51 contributions made by PhD students and session coordinators on traditional topics (astro-particles, cosmology, standard model) and on instrumentation, neutrinos, nuclear physics and hadronics. As far as astro-particles are concerned, the subjects were: Life and work of astro-particles; Alpha Magnetic Spectrometer 02, a particle sensor on the International Space Station; Anisotropy of cosmic radiation between 10 GeV and 100 TeV; H.E.S.S. and the cosmic accelerators called blazars; Ultra-high energy neutrinos at the Pierre Auger Laboratory; Autonomous radio-detection of high-energy cosmic rays with Codalema. The second theme was 'Beyond the standard model': Physics beyond the standard model; Probing the photon helicity: from BABAR to LHCb; The search for a new physics in the t t invariant mass spectrum with the CMS experiment; To connect supersymmetry and dark matter; Fine tuning in the NMSSM according to the results at 1fb -1 of the LHC; Search for new physics in events with 4 top quarks in the ATLAS experiment. For cosmology: Cosmological context; Physical properties of type Ia supernovae, the contribution of SNLS and SNFactory experiments; Reconstruction and analysis of the Sungaev-Zel'dovich effect with Planck; Local host galaxy properties of type Ia supernovae from the Nearby SuperNovae Factory; Observational cosmology with the Planck satellite: the re-ionization. For instrumentation: Introduction to instrumentation; ALFA, Absolute Luminosity For Atlas; Development of the mirrors for the second generation gravitational waves detector Advanced Virgo; EASIER, a radio detector at the Pierre Auger Laboratory; Spectral analysis algorithms in on-board gamma spectrometry; For the Standard Model: Introduction to the session; Triggering optimisation on electrons in CMS; The search for the Higgs boson in the process of vector boson fusion production and study of photon trigger with ATLAS at the LHC; Analysis of the Charmless decay B 0 → ρπ in the LHCb experiment; Correction of radiations in the final state in H → ZZ * → 4I; Towards a measurement of the γ angle of the CKM theory via the B 0 → D 0 K +0 disintegration with the LHCb detector; Measurement of the photon pair production cross section in the LHC with the ATLAS detector; The search for the Higgs in the 4-electron channel in ATLAS; Search for the Higgs boson in the H → γγ decay channel with the ATLAS detector. For neutrinos: Neutrino physics; The search for the double β disintegration without neutrino emission in the NEMO experiments; Coincident searches between gravitational waves and high-energy neutrinos with the ANTARES and LIGO/Virgo detectors; Use of the NA61-SHINE data to improve the prediction of the neutrino beam at T2K. For hadronic physics: A phenomenological study of helicity amplitudes of high energy exclusive lepto-production of the ρ-meson; Proton antiproton annihilation into heavy leptons at PANDA experiment; Study of the density of particles charged in collisions of heavy ions in the ALICE experiment at the LHC; Photon + heavy-flavor jet production at Tevatron and LHC; Quarkonium production in ultra-relativistic heavy-ion collisions with the ALICE experiment at the LHC; Loop calculations in gage theories. The last theme was nuclear physics and applications: Introduction to the session; Measurement of mass yields of the reaction 241 Am(2n,f) at the Lohengrin spectrometer; Xenon mobility in uranium dioxide; Ga-Ni coating obtained by electrodeposition in chloride environment

  10. The IBM PC as an Online Search Machine--Part 2: Physiology for Searchers.

    Science.gov (United States)

    Kolner, Stuart J.

    1985-01-01

    Enumerates "hardware problems" associated with use of the IBM personal computer as an online search machine: purchase of machinery, unpacking of parts, and assembly into a properly functioning computer. Components that allow transformations of computer into a search machine (combination boards, printer, modem) and diagnostics software…

  11. STRESS FRACTURE PREVALENCE IN ELITE FIGURE SKATERS

    Directory of Open Access Journals (Sweden)

    Sanda Dubravcic-Simunjak

    2008-09-01

    Full Text Available Figure skating is a physically demanding sport that requires a unique combination of artistic ability, speed, agility, flexibility and power. During the last decades not only the competitive schedule has become tougher, but after introduction of the new judging system in 2003, also more emphasis is put on difficult technical elements, jumps, steps and spins (ISU Rules, 2006. More studies about possible increasing prevalence of stress fractures in figure skaters and contributing factors are lacking (Dubravcic-Simunjak et al., 2003; Moran, 2000; Pecina et al., 1990. Therefore the aim of this study was to obtain data about the current stress fracture cumulative risk among elite junior and senior figure skaters, as well as possible factors that may contribute to stress fracture incidence. An anonymous questionnaire, divided into 5 sections, inquired about the prevalence of stress fracture were mailed and distributed to all 62 International Skating Union (ISU members by the ISU headquarters in Lausanne, Switzerland. The guidelines of the Helsinki declaration 2004 were followed. From the 644 skaters who received the questionnaire, 412 completed ones were returned from 110 female juniors (78 single skaters, 12 pair skaters and 20 ice dancers and 135 female seniors (97 single skaters, 16 pair skaters and 22 ice dancers and from 79 male juniors (47 single skaters, 12 pair skaters and 20 ice dancers and 88 male seniors (50 single skaters, 16 pair skaters and 22 ice dancers, coming from different ISU members. The response rate was 62% in females and 67% in males. The median age for female skaters was 16 years and for males 18 years (range 12-25 years. All participants started to skate between 3 and 6 years of age and started to compete in national and international competitions when they were between 5 and 7 years old. At the time of this analysis, they had been skating between 9 and 20 years.In females 41 (16.7%, and in males 25 (13.8% figure skaters

  12. Prevalence and obstetric risk factors

    African Journals Online (AJOL)

    suggest that obstetric factors increase the risk of damage to the anal sphincter and subsequent development of AI.[4-6] These ... variations may impact on obstetric risk factors and AI prevalence. We therefore performed a study in our population, which .... Regulatory approvals. Institutional and hospital ethical approval were ...

  13. EAMJ October prevalence.indd

    African Journals Online (AJOL)

    2008-10-10

    Oct 10, 2008 ... All the children were from a low socio-economic community with little access to proper medical/dental health care. The prevalence ... young patient and lead to difficulties in behaviour management during a dental visit. ... education, parental profession and the number of siblings in the family was sent to and ...

  14. PREVALENCE OF ACCOMMODATIVE INSUFFICIENCY AND ...

    African Journals Online (AJOL)

    PUBLICATIONS1

    Department of Optometry and Visual Sciences. KNUST, Kumasi. ABSTRACT. This study sought to determine the prevalence of accommodative dysfunctions among Junior. High School students in the Sunyani Municipality in the Brong Ahafo region of Ghana. All the. 204 students who were present in the randomly selected ...

  15. Put Theory into Practice

    Science.gov (United States)

    Jaeger, Audrey J.; Dunstan, Stephany; Thornton, Courtney; Rockenbach, Alyssa B.; Gayles, Joy G.; Haley, Karen J.

    2013-01-01

    When making decisions that impact student learning, college educators often consider previous experiences, precedent, common sense, and advice from colleagues. But how often do they consider theory? At a recent state-level educators' meeting, the authors of this article asked 50 student affairs educators about the use of theory in their practice.…

  16. Putting it in Perspective

    DEFF Research Database (Denmark)

    Jensen, Kasper Løvborg; Winschiers-Theophilus, Heike; Rodil, Kasper

    2012-01-01

    As part of a long-term research and co-design project we are creating a 3D visualization interface for an indigenous knowledge (IK) management system with rural dwellers of the Herero tribe in Namibia. Evaluations of earlier prototypes and theories on cultural differences in perception led us...... to further investigate the suitability of different perspectives of view for the given user group. Through a combination of drawing sessions, design discussions and a high-fidelity technology probe we explored the visual perceptions and preferences of community members; specifically focusing...... on representation and recognition of objects and places in their everyday environment. We report how the findings from the study have informed design decisions for our particular system while also suggesting that certain viewing angles for 3D visualizations could be more suitable for the Herero and similar rural...

  17. Putting tumours in context

    Energy Technology Data Exchange (ETDEWEB)

    Bissell, Mina J.; Radisky, Derek

    2001-10-01

    The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumor growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets. Under normal conditions, ORGANS are made up of TISSUES that exchange information with other cell types via cell-cell contact, cytokines and the EXTRACELLULAR MATRIX (ECM). The ECM, which is produced by collaboration between STROMAL fibroblasts and EPITHELIAL cells, provides structural scaffolding for cells, as well as contextual information. The endothelial vasculature provides nutrients and oxygen, and cells of the immune system combat pathogens and remove apoptotic cells. Epithelial cells associate into intact, polarized sheets. These tissues communicate through a complex network of interactions: physically, through direct contact or through the intervening ECM, and biochemically, through both soluble and insoluble signalling molecules. In combination, these interactions provide the information that is necessary to maintain cellular differentiation and to create complex tissue structures. Occasionally, the intercellular signals that define the normal context become disrupted. Alterations in epithelial tissues can lead to movement of epithelial sheets and proliferation - for example, after activation of mesenchymal fibroblasts due to wounding.Normally, these conditions are temporary and reversible, but when inflammation is sustained, an escalating feedback loop ensues.Under persistent inflammatory conditions, continual upregulation of enzymes such as matrix metalloproteinases (MMPs) by stromal fibroblasts can disrupt the ECM, and invading immune cells can overproduce factors that promote abnormal proliferation. As this process progresses, the normal organization of the organ is replaced by a functional disorder. If there are pre-existing epithelial cells within this changing context that possess tumorigenic potential, they can start to proliferate. Alternatively, the abnormal interactions might lead to genomic instability within the epithelial cells and the acquisition of tumorigenic potential. The proliferating cancer cells can then interact with their microenvironment and enhance the abnormal interactions. At this point, the tumor has become its own organ, with a distinct context that now defines all its cellular responses. Here, we will examine how the mechanisms that contribute to the normal context also act to suppress developing tumors, how disruption of this context initiates and supports the process of tumorigenicity, and how some cells with a tumorigenic genotype can become phenotypically normal if the context is appropriately manipulated.

  18. Putting Foundations Into Mathematics

    Science.gov (United States)

    Hubbard, G. L.

    1972-01-01

    For meaningful learning of mathematics, a learning set is required which demands that all things accepted as true should be demonstrable in terms of a paradigm appropriate to the child's cognitive development: preparatory, concrete-particular, concrete-general, formal-abstract. Future teachers should experience all paradigms to become aware that…

  19. Putting Veterans to Work

    Science.gov (United States)

    2012-02-13

    provide veteran benefits without sharing information or tying benefits usage to employment success. The VA does not provide benefits usage ...1965-1976) and Millennials (born 1977- 1994), the two generations heavily affected by rising unemployment, derive their information from print...second only to the internet .68 Mrs. Obama announced at the Chamber of Commerce event of December 2011 that the International Franchising Association

  20. I Put That There

    Science.gov (United States)

    Morley

    2013-01-01

    Street artist Morley describes how his perspective on graffiti changed when more cosmopolitan art school peers introduced him to what at the time was being redefined from "vandalism" to "street art." Morley explains that, as fascinated as he was, his untrained suburban eyes couldn't make out the words or their meaning in…

  1. Putting PSA to work

    International Nuclear Information System (INIS)

    Gubler, R.; Gomez-Cobo, A.

    1998-01-01

    The IAEA has, during the last three years, been working intensively on PSA applications. The draft TECDOC prepared during these activities, ''PSA Applications'' is summarized in this paper. Actual events at nuclear facilities provide an important basis to compare PSAs with reality. PSA based operational event analysis therefore can be used to evaluate the importance of operational events from a risk perspective but also can contribute to validating and enhancing PSAs and to continuously check whether or not the PSA models are adequate, appropriate and complete. The work of the IAEA in this area is therefore summarized as well. In a companion paper, titled ''Towards a credible PSA fit for applications'', two specific aspects regarding the quality of the PSA to be used are discussed in detail, namely the Living PSA concept, which ensures that the PSA reflects actual design and operational features and Quality Assurance for PSA. (author)

  2. Putting it together.

    Science.gov (United States)

    Hughes, J

    1977-05-01

    Canadian Health and Welfare Minister Marc Lalonde announced major family planning changes in federal policy at a conference of leaders of major women's organizations. Matching funds are to be made available to the provinces for the universal promotion of family planning information at no cost to the public, and the provinces will be pressed to improve their abortion services. The 1st federal attempt to promote family planning is to be a pamphlet mailed to those receiving family allowance checks.

  3. Putting nuclear in perspective

    International Nuclear Information System (INIS)

    Ekengren, Lars

    2002-01-01

    The film is made to create an open platform for discussion around energy and nuclear in specific. By bringing up many difficult issues in the film you broaden the perspective. The advantages and disadvantages of energy production is shown for the main energy sources and nuclear is more likely to be dealt with as any other industry activity with its benefits to society. When you have nuclear in a large picture the discussion or your point will be favoured by the more complete message. The industry is good at discussing nuclear from a defence perspective. We have more than 20 years of practice. It has been essential for us and the public to understand the negative effects from nuclear but the debate has been unbalanced for many years. There is a risk that we be routine start defending our self with out being asked to do so. The film is a tool to avoid us getting stuck in the old trenches. Many young people who don't have any experience from TMI and Chernobyl are not particularly interested in hearing us defend it. We are now an institutionalised part of the society with again, its advantages and disadvantages. If you are 15 years old you were not born by the time of Chernobyl. For young people in special it is essential to be open and inform. Not pushing ideas. If we like to be a part of the solution we must focus on how to use nuclear as a good part of the solution. (author)

  4. Putting it into Practice

    CERN Document Server

    Burnet, J-P

    2015-01-01

    This paper presents the latest trends in the powering of particle accelerators. A series of solutions is proposed for responding to the challenges of high performance machines. This paper covers the domains of magnetic field uncertainty, power converter control, and energy saving. This list is not exhaustive, but it does correspond to the latest innovations in the field of powering particle accelerators.

  5. Putting out to sea

    International Nuclear Information System (INIS)

    1970-01-01

    Reactor design generally has undergone development, and a considerable number of marine reactors have been built. It is now possible to say that it appears a sound technological basis exists for embarking on the design and construction of new ships particularly suited for nuclear propulsion, including large submerged tankers and cargo ships to serve special routes and to carry out special missions. But if nuclear power is to be widely used for ship propulsion much more work remains to be done - in relation both to technical aspects of reactor and ship design, and to the economics of nuclear propulsion, insurance, and the all-important question of ensuring safety. All this will require a great deal of international co-operation and agreement: a nuclear-powered cargo ship would be useless if it were not allowed to enter the ports it was intended to serve. A new symposium on nuclear ships is therefore to be held, in Hamburg from 10-15 May next year. The object of this meeting will be to review the current status of and projected developments in technical and economic aspects of nuclear ships, and the special problems associated with their safety regulation and liability. The symposium could not only provide an opportunity for exchange of the latest information in the field, but pave the way for faster development of nuclear ships in co-operation between countries which are interested in the possibilities they offer. This second symposium on nuclear ships is being organized by the IAEA, IMCO and the Government of the Federal Republic of Germany, in co-operation with the Studiengesellschaft zur Forderung der Kernenergieverwertung in Schiffbau und Schiffahrt e. V. (KEST), and the Gesellschaft fur Kernenergieverwertung in Schiffbau und Schiffahrt mbH (GKSS). The topics to be discussed include a review of national programmes and plans; special problems of nuclear ship design; criteria and special features for power reactors for nuclear ships; actual experience gained in the construction and operation of nuclear ships; safety and the question of entry into ports; liability for and financial cover of nuclear ships; and economics. In connection with the symposium a visit to the NS Otto Hahn, and a visit to the reactor centre at Geesthacht near Hamburg, are planned. It is hoped that the symposium will be reviewed in a later issue of the Bulletin. (author)

  6. Putting politics aside.

    Science.gov (United States)

    2010-06-01

    At the time of writing, voters in the UK were going to the polls for the general election. Promises have been made about meeting the needs of the ageing society and rhetoric about dignity for older people has been heard, but it is nurses who actually deliver results in these areas.

  7. Putting Research to Work

    Science.gov (United States)

    Patschke, Melissa D.

    2012-01-01

    Every principal and teacher in every K-8 school in the country knows that children who struggle with difficult social, emotional, or behavioral issues also have difficulty learning. What educators do not always know is how to help these students. What are best practices in this area, and how can a principal and his or her staff implement them? As…

  8. Putting Diversity to Work

    DEFF Research Database (Denmark)

    Holck, Lotte

    2016-01-01

    Purpose: The purpose of this article is to critically explore why a diversity agenda in favor of equal opportunities failed despite apparent organizational support and commitment to diversity. Design/methodology/approach: Drawing on data from a municipal center, this study inquires into how....... Accordingly, change efforts must necessarily address diversity in a situated perspective and as intersecting with key organizational power dynamics gaining impetus from macro discourses on diversity and difference. Originality/value: Few critical diversity scholars engage with practitioners and reflect...... organizational dynamics of power and hierarchy influence change efforts to alter practices of inequality. The study is positioned within critical diversity research and structured around an analysis of the researcher’s fieldwork experiences. Findings: The analysis examines into why change efforts failed despite...

  9. Put on My Shoes

    Centers for Disease Control (CDC) Podcasts

    2007-11-01

    This podcast encourages increased physical activity to the tune of original music.  Created: 11/1/2007 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 11/29/2007.

  10. Putting Law into Ethics.

    Science.gov (United States)

    Lieberman, Jethro K.

    1979-01-01

    The evolution of ethics in law is followed from the harshness of caveat emptor to the humanistic ethics of the 1970s, including a renewal of formal ethics in the post-Watergate era. The impact on universities and individual disciplines of legalizing ethical conduct is examined cautiously. (JMF)

  11. Put to the test

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    This summer, the HiRadMat (High Radiation to Materials) facility began testing the first HL-LHC collimator jaw prototypes. How they perform when bombarded with high-energy, high-intensity beams will go on to shape the particle accelerators of the future...   The three collimator jaws prior to installation in the HiRadMat facility. Preliminary results have found that molybdenum-graphite is by far the most robust of the novel materials. As copper-diamond is denser and more electrically conductive, it may have applications in the HL-LHC collimation system locations less exposed to beam accidents.   The HiRadMat facility uses SPS beams to test materials and accelerator components in extreme conditions. As accelerators grow more powerful, they require materials that can withstand extreme conditions of temperature and pressure as well as high levels of radiation. In 2012, in a HiRadMat experiment, six different materials were probed for possible use in collimators and absorbers. The re...

  12. Putting research to work

    International Development Research Centre (IDRC) Digital Library (Canada)

    2013-03-31

    Mar 31, 2013 ... Food Security. Research Fund. • Collaborative. Adaptation. Research Initiative in Africa and Asia. • Climate. Change and environmental economics. • ecosystems and ..... IDRC supports Canada's goal of increasing food security through ... As part of Canada's commitment to fast-start financing for.

  13. Prevalence of Myopia in France

    Science.gov (United States)

    Matamoros, Emilie; Ingrand, Pierre; Pelen, François; Bentaleb, Yacine; Weber, Michel; Korobelnik, Jean-François; Souied, Eric; Leveziel, Nicolas

    2015-01-01

    Abstract Refractive error (RE), particularly myopia, is the first cause of visual impairment throughout the world. This study aimed to depict the prevalence of myopia in a multicentric series of French individuals. This cross-sectional analysis was carried out between January 2012 and November 2013 in eye clinics dedicated to REs. Data collection included age, gender, best-corrected visual acuity, RE, and any relevant medical history involving laser refractive surgery and cataract surgery. Exclusion criteria consisted of monophthalm patients or those with incomplete demographic data. Prevalences in the overall population, by gender and by age groups were reported for mild myopia (−0.50 to −2.75 diopter [D]), moderate myopia (−3 to −5.75 D), high myopia (less than −6 D), and very high myopia (less than −10 D). The analysis included 100,429 individuals, mean age 38.5 years (± 16.9). Overall prevalence of myopia was 39.1% (95% CI 38.8-39.4). Prevalences of mild, moderate, high and very high myopia were respectively 25.1% (95% CI 25.4-24.9), 10.6% (95% CI 10.4-10.8), 3.4% (95% CI 3.3-3.5) and 0.5% (95% CI 0.48-0.57). Even if possible bias occurred in recruitment, our results are similar to RE data collected in nationally representative samples of Caucasians in other studies. This is to our knowledge, one of the largest European series of individuals dedicated to myopia prevalences in different age groups. These results confirm the importance of myopia as a major health issue in Western countries. PMID:26559276

  14. Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli.

    Science.gov (United States)

    Moxley, Michael A; Tanner, John J; Becker, Donald F

    2011-12-15

    The multifunctional proline utilization A (PutA) flavoenzyme from Escherichia coli performs the oxidation of proline to glutamate in two catalytic steps using separate proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate (P5C) dehydrogenase domains. In the first reaction, the oxidation of proline is coupled to the reduction of ubiquinone (CoQ) by the PRODH domain, which has a β(8)α(8)-barrel structure that is conserved in bacterial and eukaryotic PRODH enzymes. The structural requirements of the benzoquinone moiety were examined by steady-state kinetics using CoQ analogs. PutA displayed activity with all the analogs tested; the highest k(cat)/K(m) was obtained with CoQ(2). The kinetic mechanism of the PRODH reaction was investigated use a variety of steady-state approaches. Initial velocity patterns measured using proline and CoQ(1), combined with dead-end and product inhibition studies, suggested a two-site ping-pong mechanism for PutA. The kinetic parameters for PutA were not strongly influenced by solvent viscosity suggesting that diffusive steps do not significantly limit the overall reaction rate. In summary, the kinetic data reported here, along with analysis of the crystal structure data for the PRODH domain, suggest that the proline:ubiquinone oxidoreductase reaction of PutA occurs via a rapid equilibrium ping-pong mechanism with proline and ubiquinone binding at two distinct sites. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Pain prevalence in hospitalized children

    DEFF Research Database (Denmark)

    Walther-Larsen, S; Pedersen, M T; Friis, S M

    2017-01-01

    BACKGROUND: Pain management in hospitalized children is often inadequate. The prevalence and main sources of pain in Danish university hospitals is unknown. METHODS: This prospective mixed-method cross-sectional survey took place at four university hospitals in Denmark. We enrolled 570 pediatric...... patients who we asked to report their pain experience and its management during the previous 24 hours. For patients identified as having moderate to severe pain, patient characteristics and analgesia regimes were reviewed. RESULTS: Two hundred and thirteen children (37%) responded that they had experienced...... pain in the previous 24 hours. One hundred and thirty four (24%) indicated moderate to severe pain and 43% would have preferred an intervention to alleviate the pain. In children hospitalized for more than 24 hours, the prevalence of moderate/severe pain was significantly higher compared to children...

  16. Prevalent knee pain and sport

    DEFF Research Database (Denmark)

    Hahn, Thomas; Foldspang, Anders

    1998-01-01

    and with weekly hours of participation in competitive gymnastics but negatively with weekly hours of tennis. Constant or recurrent knee pain was positively associated with years of swimming. Absence from sport due to knee pain was positively associated with weekly hours of soccer participation. CONCLUSIONS: Knee...... pain is a common symptom in athletes. The prevalence is associated with the type, amount and duration of sports participation....

  17. Insomnia: prevalence and associated factors

    OpenAIRE

    Lopes, Cátia; Lopes, Daniela; Ferreira, Sofia; Correia, Teresa; Pinto, Isabel C.

    2014-01-01

    Nowadays sleep disorders are very common and affect most of the population, the most common may be insomnia. Insomnia is defined as the difficulty of initiating or maintaining sleep it, may also be reflected in an early wake up and by the presence of a non-restful sleep and it is associated with impairment in social and occupational functioning of the individual. Knowing the prevalence and the associated factors of insomnia. This is a cross-sectional epidemiological study. The pop...

  18. Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site.

    Science.gov (United States)

    Singh, Harkewal; Arentson, Benjamin W; Becker, Donald F; Tanner, John J

    2014-03-04

    Proline utilization A (PutA) proteins are bifunctional peripheral membrane flavoenzymes that catalyze the oxidation of L-proline to L-glutamate by the sequential activities of proline dehydrogenase and aldehyde dehydrogenase domains. Located at the inner membrane of Gram-negative bacteria, PutAs play a major role in energy metabolism by coupling the oxidation of proline imported from the environment to the reduction of membrane-associated quinones. Here, we report seven crystal structures of the 1,004-residue PutA from Geobacter sulfurreducens, along with determination of the protein oligomeric state by small-angle X-ray scattering and kinetic characterization of substrate channeling and quinone reduction. The structures reveal an elaborate and dynamic tunnel system featuring a 75-Å-long tunnel that links the two active sites and six smaller tunnels that connect the main tunnel to the bulk medium. The locations of these tunnels and their responses to ligand binding and flavin reduction suggest hypotheses about how proline, water, and quinones enter the tunnel system and where L-glutamate exits. Kinetic measurements show that glutamate production from proline occurs without a lag phase, consistent with substrate channeling and implying that the observed tunnel is functionally relevant. Furthermore, the structure of reduced PutA complexed with menadione bisulfite reveals the elusive quinone-binding site. The benzoquinone binds within 4.0 Å of the flavin si face, consistent with direct electron transfer. The location of the quinone site implies that the concave surface of the PutA dimer approaches the membrane. Altogether, these results provide insight into how PutAs couple proline oxidation to quinone reduction.

  19. Putting the Deep Biosphere on the Map for Oceanography Courses: Gas Hydrates As a Case Study for the Deep Biosphere

    Science.gov (United States)

    Sikorski, J. J.; Briggs, B. R.

    2014-12-01

    The ocean is essential for life on our planet. It covers 71% of the Earth's surface, is the source of the water we drink, the air we breathe, and the food we eat. Yet, the exponential growth in human population is putting the ocean and thus life on our planet at risk. However, based on student evaluations from our introductory oceanography course it is clear that our students have deficiencies in ocean literacy that impact their ability to recognize that the ocean and humans are inextricably connected. Furthermore, life present in deep subsurface marine environments is also interconnected to the study of the ocean, yet the deep biosphere is not typically covered in undergraduate oceanography courses. In an effort to improve student ocean literacy we developed an instructional module on the deep biosphere focused on gas hydrate deposits. Specifically, our module utilizes Google Earth and cutting edge research about microbial life in the ocean to support three inquiry-based activities that each explore different facets of gas hydrates (i.e. environmental controls, biologic controls, and societal implications). The relevant nature of the proposed module also makes it possible for instructors of introductory geology courses to modify module components to discuss related topics, such as climate, energy, and geologic hazards. This work, which will be available online as a free download, is a solid contribution toward increasing the available teaching resources focused on the deep biosphere for geoscience educators.

  20. Effect of a Sinorhizobium meliloti strain with a modified putA gene on the rhizosphere microbial community of alfalfa.

    Science.gov (United States)

    van Dillewijn, Pieter; Villadas, Pablo J; Toro, Nicolás

    2002-09-01

    The success of a rhizobial inoculant in the soil depends to a large extent on its capacity to compete against indigenous strains. M403, a Sinorhizobium meliloti strain with enhanced competitiveness for nodule occupancy, was recently constructed by introducing a plasmid containing an extra copy of a modified putA (proline dehydrogenase) gene. This strain and M401, a control strain carrying the same plasmid without the modified gene, were used as soil inoculants for alfalfa in a contained field release experiment at León, Spain. In this study, we determined the effects of these two strains on the indigenous microbial community. 16S rRNA genes were obtained from the rhizosphere of alfalfa inoculated with strain M403 or strain M401 or from noninoculated plants by amplification of DNA from soil with bacterial group-specific primers. These genes were analyzed and compared by restriction fragment length polymorphism and temperature gradient gel electrophoresis. The results allowed us to differentiate between alterations in the microbial community apparently caused by inoculation and by the rhizosphere effect and seasonal fluctuations induced by the alfalfa plants and by the environment. Only moderate inoculation-dependent effects could be detected, while the alfalfa plants appeared to have a much stronger influence on the microbial community.

  1. Equity reporting: a framework for putting knowledge mobilization and health equity at the core of population health status reporting.

    Science.gov (United States)

    Dyck, Lesley Ann; Snelling, Susan; Morrison, Val; Haworth-Brockman, Margaret; Atkinson, Donna

    2018-03-01

    The National Collaborating Centres for Public Health (NCCPH) collaborated on the development of an action framework for integrating equity into population health status reporting. This framework integrates the research literature with on-the-ground experience collected using a unique collaborative learning approach with public health practitioners from across Canada. This article introduces the Action Framework, describes the learning process, and then situates population health status reporting (PHSR) in the current work of the public health sector. This is followed by a discussion of the nature of evidence related to the social determinants of health as a key aspect of deciding what and how to report. Finally, the connection is made between data and implementation by exploring the concept of actionable information and detailing the Action Framework for equity-integrated population health status reporting. The article concludes with a discussion of the importance of putting knowledge mobilization at the core of the PHSR process and makes suggestions for next steps. The purpose of the article is to encourage practitioners to use, discuss, and ultimately strengthen the framework.

  2. Putting solid household waste to sustainable use: a case study in the city of Rio de Janeiro, Brazil.

    Science.gov (United States)

    Carvalho, Márcia da Silva; Rosa, Luiz Pinguelli; Bufoni, André Luiz; Oliveira, Luciano Basto

    2012-12-01

    The management of solid residues has, in recent decades, been a source of concern for public administrators the world over. Experiments in the sustainable use of such residues are highly relevant in social and environmental terms, stimulating widespread interest and debate, with considerable research going into sustainability projects. In many areas, however, adequate public funding for sustainable-use projects is hard to come by. One of the major reasons for this is that public authorities, particularly in times of financial constraints, are reluctant to invest in undertakings in which the economic returns are difficult to quantify. Official scrutiny of the expenditures of public authorities is also normally heavily influenced by cost-benefit analyses. The specific objective of this article is to show that putting solid domestic residue (household solid waste) to sustainable use is capable of generating economic returns, as well as environmental benefits for society as a whole. These economic returns can be set out in financial statements, which may, in turn, be used to justify expenditures by public authorities on sustainable-use projects and as a basis for further investment in such incentives. We drew on the findings of existing research into sustainable use, undertaken by the Municipal Urban Cleaning Company in the city of Rio de Janeiro, Brazil, to establish a conceptual framework for setting out the economic results of the collection of household solid waste.

  3. Working with bacteria and putting bacteria to work: The biopolitics of synthetic biology for energy in the United Kingdom.

    Science.gov (United States)

    McLeod, Carmen; Nerlich, Brigitte; Mohr, Alison

    2017-08-01

    The UK government has made significant investment into so called 'fourth-generation' biofuel technologies. These biofuels are based on engineering the metabolic pathways of bacteria in order to create products compatible with existing infrastructure. Bacteria play an important role in what is promoted as a potentially new biological industrial revolution, which could address some of the negative environmental legacies of the last. This article presents results from ethnographic research with synthetic biologists who are challenged with balancing the curiosity-driven and intrinsically fulfilling scientific task of working with bacteria, alongside the policy-driven task of putting bacteria to work for extrinsic economic gains. In addition, the scientists also have to balance these demands with a new research governance framework, Responsible Research and Innovation, which envisions technoscientific innovation will be responsive to societal concerns and work in collaboration with stakeholders and members of the public. Major themes emerging from the ethnographic research revolve around stewardship, care, responsibility and agency. An overall conflict surfaces between individual agents assuming responsibility for 'stewarding' bacteria, against funding systems and structures imposing responsibility for economic growth. We discuss these findings against the theoretical backdrop of a new concept of 'energopolitics' and an anthropology of ethics and responsibility.

  4. Putting Corporate Social Responsibility to Work in Mining Communities: Exploring Community Needs for Central Appalachian Wastewater Treatment

    Directory of Open Access Journals (Sweden)

    Nicholas Cook

    2015-04-01

    Full Text Available Due to the finite nature of non-renewable mineral and energy resources such as coal, resource extraction is inherently unsustainable; however, mining and related activities can contribute to sustainable development. Indeed, the principles of corporate social responsibility (CSR require that mine operators design and conduct their activities in ways that provide for net positive impacts on surrounding communities and environments. In Central Appalachia, there appears to be a particularly ripe opportunity for the coal industry to put CSR to work: participation in sustainable solutions to the long-standing problem of inadequately treated wastewater discharges—which not only represent a potential human health hazard, but also contribute to the relatively high incidence of bacterial impairments in surface waters in the region. In this paper, we outline the underlying factors of this problem and the advantages of industry-aided solutions in a region where limited economic and technical resources are not always aligned with social and environmental needs. We also suggest a framework for problem-solving, which necessarily involves all interested stakeholders, and identify the primary challenges that must be overcome in pursuit of sustainable solutions.

  5. Age effects shrink when motor learning is predominantly supported by nondeclarative, automatic memory processes: evidence from golf putting.

    Science.gov (United States)

    Chauvel, Guillaume; Maquestiaux, François; Hartley, Alan A; Joubert, Sven; Didierjean, André; Masters, Rich S W

    2012-01-01

    Can motor learning be equivalent in younger and older adults? To address this question, 48 younger (M = 23.5 years) and 48 older (M = 65.0 years) participants learned to perform a golf-putting task in two different motor learning situations: one that resulted in infrequent errors or one that resulted in frequent errors. The results demonstrated that infrequent-error learning predominantly relied on nondeclarative, automatic memory processes whereas frequent-error learning predominantly relied on declarative, effortful memory processes: After learning, infrequent-error learners verbalized fewer strategies than frequent-error learners; at transfer, a concurrent, attention-demanding secondary task (tone counting) left motor performance of infrequent-error learners unaffected but impaired that of frequent-error learners. The results showed age-equivalent motor performance in infrequent-error learning but age deficits in frequent-error learning. Motor performance of frequent-error learners required more attention with age, as evidenced by an age deficit on the attention-demanding secondary task. The disappearance of age effects when nondeclarative, automatic memory processes predominated suggests that these processes are preserved with age and are available even early in motor learning.

  6. National prevalence of respiratory allergic disorders

    NARCIS (Netherlands)

    Dahl, R; Andersen, PS; Chivato, T; Valovirta, E; De Monchy, J

    Background: Many epidemiological studies have assessed the prevalence of respiratory allergic disorders in confined geographical locations. However, no study has yet established nationally prevalence data in a uniform manner representing whole countries and, thus, enabling cross-national

  7. Prevalence Of Intestinal Helminths infections among schooling ...

    African Journals Online (AJOL)

    Central Schoo, Ovoko had the highest percent prevalence for Ascaris lumbricoides (9.3 %), hookworm (6.0 %) and Trichuris trichiura (2.3 %). The least per cent prevalence of A. lumbricoides was recorded in Community Primary School, Iheakpu-Awka (2.3 %), while the least per cent prevalence of hookworm occurred in ...

  8. Increasing Autism Prevalence in Metropolitan New Jersey

    Science.gov (United States)

    Zahorodny, Walter; Shenouda, Josephine; Howell, Sandra; Rosato, Nancy Scotto; Peng, Bo; Mehta, Uday

    2014-01-01

    High baseline autism spectrum disorder prevalence estimates in New Jersey led to a follow-up surveillance. The objectives were to determine autism spectrum disorder prevalence in the year 2006 in New Jersey and to identify changes in the prevalence of autism spectrum disorder or in the characteristics of the children with autism spectrum disorder,…

  9. Prevalence and socioeconomic factors in schistosoma ...

    African Journals Online (AJOL)

    Prevalence of Schistosoma haematobium infections was assessed among 160 students of Twohofo Holy International School. Cape Coast, Ghana. Overall prevalence was 34.4%, with males and females having prevalence of 32.3% and 35.8% respectively. Ago group 6-B years had 30%, while 24.2% were infected in age ...

  10. Antibiotic susceptibilities and prevalence of Methicillin resistant Staphylococcus aureus (MRSA) isolated from bovine milk in Pakistan.

    Science.gov (United States)

    Aqib, Amjad Islam; Ijaz, Muhammad; Anjum, Aftab Ahmad; Malik, Muhammad Abdul Rauf; Mehmood, Khalid; Farooqi, Shahid Hussain; Hussain, Kashif

    2017-12-01

    The study was designed to investigate bovine milk for prevalence of an emerging zoonotic pathogen Methicillin resistant Staphylococcus aureus (MRSA), and in-vitro therapeutic response of various antibiotics against MRSA. Nine hundred (900) milk samples were collected (half from cattle and half from buffalo) from private and public farms located in various tehsils of district Faisalabad, using the convenient sampling method. Milk samples were put to biochemical identification of Staphylococcus aureus and later oxacilline disk sensitivity testing for confirmation of MRSA. The MRSA isolates were confirmed by PCR targeting mecA gene in Staphylococcus aureus. The study found 34% prevalence of MRSA in overall bovine milk from district Faisalabad with 30% and 38% prevalence in cattle and buffalo, respectively. Tehsil Samundari presented comparatively higher MRSA prevalence followed by tehsil Jaranwala and tehsil Faisalabad. However, there was non-significant difference of MRSA prevalence between cattle and buffalo, and among different tehsils. All assumed risk factors except specie were significantly associated with mastitis spread. The in-vitro drug trial against MRSA from buffalo milk presented 100% efficacy of Ciprofloxcin, Moxifloxacin, Linezolid, and Trimethoprim plus Sulphamethoxazole combination, followed by Gentamicin and Levofloxacin presenting 90%, and Amikacin becoming 80% efficacious against MRSA from buffalo milk. The MRSA isolates of cattle milk presented similar pattern with some variations of higher susceptibility against Oxytetracycline, and Fusidic acid. The conclusion of the study states uniform prevalence of MRSA in cattle and buffalo milk in study area having assumed risk factors positively associated with disease spread, while Ciprofloxcin, Moxifloxacin, Linezolid, and Trimethoprim plus Sulphamethoxazole drugs showed the highest efficacy to combat this pathogen. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Brucellosis and bovine tuberculosis prevalence in livestock from pastoralist communities adjacent to Awash National Park, Ethiopia.

    Science.gov (United States)

    Tschopp, Rea; Bekele, Shiferaw; Moti, Tesfaye; Young, Douglas; Aseffa, Abraham

    2015-06-15

    This cross-sectional study investigated the prevalence of brucellosis and bovine tuberculosis (BTB) in local cattle and goat breeds of Oromo and Afar pastoralist communities living in two distinct parts around the Awash National Park. A questionnaire survey was carried out to assess information on husbandry, milk consumption habits, and on knowledge-attitude-practice regarding both diseases. Among a total of 771 animals from all sites tested by comparative intradermal tuberculin test (CIDT) none were BTB reactors with the >4mm cut-off. Using the >2mm cut-off, individual apparent prevalence was 0.9% (95%CI: 0.23-3.56%) in cattle and 0.7% (95%CI: 0.12-3.45%) in goats. Herd prevalence in Oromia and Afar sites was 0% and 66.7% respectively in goats and 16.7% and 50% in cattle. Among the 327 animals tested by enzyme linked immunoassay for brucellosis, 4.8% (95%CI: 1.2-17.1%) of cattle and 22.8% (95%CI: 5.98-29.5%) of goats were reactors. Highest individual prevalence of both diseases was found in Afar settlements with brucellosis being as high as 50%. Respondent ethnicity was the only risk factor for brucellosis positivity in goats in the univariable risk factor analysis. Knowledge about the diseases was poor. Raw goat milk was regularly consumed by women and children, putting them at risk for brucellosis. This study highlighted an increased prevalence gradient of BTB and brucellosis from West to East along the study sites with high brucellosis individual prevalence and abortion rates among Afar settlements in particular. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Putting Order into Our Universe: The Concept of Blended Learning—A Methodology within the Concept-based Terminology Framework

    Directory of Open Access Journals (Sweden)

    Joana Fernandes

    2016-06-01

    Full Text Available This paper aims at discussing the advantages of a methodology design grounded on a concept-based approach to Terminology applied to the most prominent scenario of current Higher Education: blended learning. Terminology is a discipline that aims at representing, describing and defining specialized knowledge through language, putting order into our universe (Nuopponen, 2011. Concepts, as elements of the structure of knowledge (Sager, 1990 emerge as a complex research object. Can they be found in language? A concept-based approach to Terminology implies a clear-cut view of the role of language in terminological work: though language is postulated as being a fundamental tool to grasp, describe and organize knowledge, an isomorphic relationship between language and knowledge cannot be taken for granted. In other words, the foundational premise of a concept-based approach is that there is no one-to-one correspondence between atomic elements of knowledge and atomic elements of linguistic expression. This is why a methodological approach to Terminology merely based upon specialized text research is regarded as biased (Costa, 2013. As a consequence, we argue that interactional strategies between terminologist and domain expert deserve particular research attention. To our mind, the key to concept-based terminological work is to carry out a concept analysis of data gathered from a specialised text corpora combined with an elicitation process of the tacit knowledge and concept-oriented discursive negotiation. Following such view, we put forward a methodology to answer the question: how is blended learning defined in the Post-Bologna scenario? Even though there are numerous high-quality models and practical descriptions for its implementation (similarly to other concepts related to distance learning, the need to understand, demarcate and harmonize the concept of blended learning against the current Higher Education background results from the premise that

  13. Putting newborn hearing screening on the political agenda in Belgium: local initiatives toward a community programme - a qualitative study.

    Science.gov (United States)

    Vos, Bénédicte; Lagasse, Raphaël; Levêque, Alain

    2014-07-01

    The Kingdon model, based on the convergence of three streams (problem, policy, and politics) and the opening of a policy window, analyses the process by which a health issue is placed on the political agenda. We used this model to document the political agenda-setting process of the newborn hearing screening programme in Belgium. A qualitative study based on a document review and on semi-directed interviews was carried out. The interviews were conducted with nine people who had played a role in putting the issue in question on the political agenda, and the documents reviewed included scientific literature and internal reports and publications from the newborn hearing screening programme. The thematic analysis of the data collected was carried out on the basis of the Kingdon model's three streams. The political agenda-setting of this screening programme was based on many factors. The problem stream included factors external to the context under study, such as the technological developments and the contribution of the scientific literature which led to the recommendation to provide newborn hearing screening. The two other streams (policy and politics) covered factors internal to the Belgian context. The fact that it was locally feasible with financial support, the network of doctors convinced of the need for newborn hearing screening, the drafting of various proposals, and the search for financing were all part of the policy stream. The Belgian political context and the policy opportunities concerning preventive medicine were identified as significant factors in the third stream. When these three streams converged, a policy window opened, allowing newborn hearing screening onto the political agenda and enabling the policy decision for its introduction. The advantage of applying the Kingdon model in our approach was the ability to demonstrate the political agenda-setting process, using the three streams. This made it possible to identify the many factors involved in

  14. Why a Paradigm Shift of "More than Human Ontologies" Is Needed: Putting to Work Poststructural and Posthuman Theories in Writers' Studio

    Science.gov (United States)

    Kuby, Candace R.

    2017-01-01

    This manuscript puts to work "more than human ontologies" drawing on poststructural (rhizomatic) and posthumanist (intra-active) theories by plugging-in concepts with data produced in a second grade Writers' Studio to illustrate why a paradigm shift of "more than human ontologies" is needed. Specifically, how ways of…

  15. Prevalence of obesity in Denmark

    DEFF Research Database (Denmark)

    Due, P; Heitmann, B L; Sørensen, T I A

    2007-01-01

    There has been a pronounced, distinctive increase of the prevalence of obesity within almost all age groups of the Danish population, during the last 25-30 years. The largest increase has been documented in studies based on objective data from total populations and the latest data show the increase...... will continue. The Danish studies show heterogeneity in the development of the obesity epidemic. A close association with birth cohorts indicates a need for further aetiological research, not only into behavioural factors, but also into early life factors that may explain some of this developmental pattern....

  16. [Pedophilia. Prevalence, etiology, and diagnostics].

    Science.gov (United States)

    Mokros, A; Osterheider, M; Nitschke, J

    2012-03-01

    Pedophilia is a disorder of sexual preference that increases the risk for committing sexual offenses against children. Consequently, pedophilia is not only relevant in psychiatric therapy and prognostics, but also greatly influences the public attitude towards criminality. Public opinion seems to equate pedophilia with child sexual abuse and vice versa which leads to stigmatization of patients and may impede treatment. The present paper provides information on recent studies on the potential origins of the disorder and introduces new diagnostic methods. Moreover, the article presents estimates on the prevalence of pedophilic sexual interest.

  17. Probing a hydrogen bond pair and the FAD redox properties in the proline dehydrogenase domain of Escherichia coli PutA.

    Science.gov (United States)

    Baban, Berevan A; Vinod, Madhavan P; Tanner, John J; Becker, Donald F

    2004-09-01

    The PutA flavoprotein from Escherichia coli combines DNA-binding, proline dehydrogenase (PRODH), and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) activities onto a single polypeptide. Recently, an X-ray crystal structure of PutA residues 87-612 was solved which identified a D370-Y540 hydrogen bond pair in the PRODH active site that appears to have an important role in shaping proline binding and the FAD redox environment. To examine the role of D370-Y540 in the PRODH active site, mutants D370A, Y540F, and D370A/Y540F were characterized in a form of PutA containing only residues 86-601 (PutA86-601) designed to mimic the known structural region of PutA (87-612). Disruption of the D370-Y540 pair only slightly diminished k(cat), while more noticeable affects were observed in K(m). The mutant D370A/Y540F showed the most significant changes in the pH dependence of k(cat)/K(m) and K(m) relative to wild-type PutA86-601 with an apparent pK(a) value of about 8.2 for the pH-dependent decrease in K(m). From the pH profile of D370A/Y540F inhibition by l-tetrahydro-2-furoic acid (l-THFA), the pH dependency of K(m) in D370A/Y540F is interpreted as resulting from the deprotonation of the proline amine in the E-S complex. Replacement of D370 and Y540 produces divergent effects on the E(m) for bound FAD. At pH 7.0, E(m) values of -0.026, -0.089 and -0.042 V were determined for the two-electron reduction of bound FAD in D370A, Y540F and D370A/Y540F, respectively. The 40-mV positive shift in E(m) determined for D370A relative to wild-type PutA86-601 (E(m)=-0.066 V, pH 7.0) indicates D370 has a key role in modulating the FAD redox environment.

  18. Evidence for Hysteretic Substrate Channeling in the Proline Dehydrogenase and Δ1-Pyrroline-5-carboxylate Dehydrogenase Coupled Reaction of Proline Utilization A (PutA)*

    Science.gov (United States)

    Moxley, Michael A.; Sanyal, Nikhilesh; Krishnan, Navasona; Tanner, John J.; Becker, Donald F.

    2014-01-01

    PutA (proline utilization A) is a large bifunctional flavoenzyme with proline dehydrogenase (PRODH) and Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains that catalyze the oxidation of l-proline to l-glutamate in two successive reactions. In the PRODH active site, proline undergoes a two-electron oxidation to Δ1-pyrroline-5-carboxlylate, and the FAD cofactor is reduced. In the P5CDH active site, l-glutamate-γ-semialdehyde (the hydrolyzed form of Δ1-pyrroline-5-carboxylate) undergoes a two-electron oxidation in which a hydride is transferred to NAD+-producing NADH and glutamate. Here we report the first kinetic model for the overall PRODH-P5CDH reaction of a PutA enzyme. Global analysis of steady-state and transient kinetic data for the PRODH, P5CDH, and coupled PRODH-P5CDH reactions was used to test various models describing the conversion of proline to glutamate by Escherichia coli PutA. The coupled PRODH-P5CDH activity of PutA is best described by a mechanism in which the intermediate is not released into the bulk medium, i.e., substrate channeling. Unexpectedly, single-turnover kinetic experiments of the coupled PRODH-P5CDH reaction revealed that the rate of NADH formation is 20-fold slower than the steady-state turnover number for the overall reaction, implying that catalytic cycling speeds up throughput. We show that the limiting rate constant observed for NADH formation in the first turnover increases by almost 40-fold after multiple turnovers, achieving half of the steady-state value after 15 turnovers. These results suggest that EcPutA achieves an activated channeling state during the approach to steady state and is thus a new example of a hysteretic enzyme. Potential underlying causes of activation of channeling are discussed. PMID:24352662

  19. Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA).

    Science.gov (United States)

    Moxley, Michael A; Sanyal, Nikhilesh; Krishnan, Navasona; Tanner, John J; Becker, Donald F

    2014-02-07

    PutA (proline utilization A) is a large bifunctional flavoenzyme with proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains that catalyze the oxidation of l-proline to l-glutamate in two successive reactions. In the PRODH active site, proline undergoes a two-electron oxidation to Δ(1)-pyrroline-5-carboxlylate, and the FAD cofactor is reduced. In the P5CDH active site, l-glutamate-γ-semialdehyde (the hydrolyzed form of Δ(1)-pyrroline-5-carboxylate) undergoes a two-electron oxidation in which a hydride is transferred to NAD(+)-producing NADH and glutamate. Here we report the first kinetic model for the overall PRODH-P5CDH reaction of a PutA enzyme. Global analysis of steady-state and transient kinetic data for the PRODH, P5CDH, and coupled PRODH-P5CDH reactions was used to test various models describing the conversion of proline to glutamate by Escherichia coli PutA. The coupled PRODH-P5CDH activity of PutA is best described by a mechanism in which the intermediate is not released into the bulk medium, i.e., substrate channeling. Unexpectedly, single-turnover kinetic experiments of the coupled PRODH-P5CDH reaction revealed that the rate of NADH formation is 20-fold slower than the steady-state turnover number for the overall reaction, implying that catalytic cycling speeds up throughput. We show that the limiting rate constant observed for NADH formation in the first turnover increases by almost 40-fold after multiple turnovers, achieving half of the steady-state value after 15 turnovers. These results suggest that EcPutA achieves an activated channeling state during the approach to steady state and is thus a new example of a hysteretic enzyme. Potential underlying causes of activation of channeling are discussed.

  20. Small-angle X-ray scattering studies of the oligomeric state and quaternary structure of the trifunctional proline utilization A (PutA) flavoprotein from Escherichia coli.

    Science.gov (United States)

    Singh, Ranjan K; Larson, John D; Zhu, Weidong; Rambo, Robert P; Hura, Greg L; Becker, Donald F; Tanner, John J

    2011-12-16

    The trifunctional flavoprotein proline utilization A (PutA) links metabolism and gene regulation in Gram-negative bacteria by catalyzing the two-step oxidation of proline to glutamate and repressing transcription of the proline utilization regulon. Small-angle x-ray scattering (SAXS) and domain deletion analysis were used to obtain solution structural information for the 1320-residue PutA from Escherichia coli. Shape reconstructions show that PutA is a symmetric V-shaped dimer having dimensions of 205 × 85 × 55 Å. The particle consists of two large lobes connected by a 30-Å diameter cylinder. Domain deletion analysis shows that the N-terminal DNA-binding domain mediates dimerization. Rigid body modeling was performed using the crystal structure of the DNA-binding domain and a hybrid x-ray/homology model of residues 87-1113. The calculations suggest that the DNA-binding domain is located in the connecting cylinder, whereas residues 87-1113, which contain the two catalytic active sites, reside in the large lobes. The SAXS data and amino acid sequence analysis suggest that the Δ(1)-pyrroline-5-carboxylate dehydrogenase domains lack the conventional oligomerization flap, which is unprecedented for the aldehyde dehydrogenase superfamily. The data also provide insight into the function of the 200-residue C-terminal domain. It is proposed that this domain serves as a lid that covers the internal substrate channeling cavity, thus preventing escape of the catalytic intermediate into the bulk medium. Finally, the SAXS model is consistent with a cloaking mechanism of gene regulation whereby interaction of PutA with the membrane hides the DNA-binding surface from the put regulon thereby activating transcription.

  1. Small-angle X-ray Scattering Studies of the Oligomeric State and Quaternary Structure of the Trifunctional Proline Utilization A (PutA) Flavoprotein from Escherichia coli*

    Science.gov (United States)

    Singh, Ranjan K.; Larson, John D.; Zhu, Weidong; Rambo, Robert P.; Hura, Greg L.; Becker, Donald F.; Tanner, John J.

    2011-01-01

    The trifunctional flavoprotein proline utilization A (PutA) links metabolism and gene regulation in Gram-negative bacteria by catalyzing the two-step oxidation of proline to glutamate and repressing transcription of the proline utilization regulon. Small-angle x-ray scattering (SAXS) and domain deletion analysis were used to obtain solution structural information for the 1320-residue PutA from Escherichia coli. Shape reconstructions show that PutA is a symmetric V-shaped dimer having dimensions of 205 × 85 × 55 Å. The particle consists of two large lobes connected by a 30-Å diameter cylinder. Domain deletion analysis shows that the N-terminal DNA-binding domain mediates dimerization. Rigid body modeling was performed using the crystal structure of the DNA-binding domain and a hybrid x-ray/homology model of residues 87–1113. The calculations suggest that the DNA-binding domain is located in the connecting cylinder, whereas residues 87–1113, which contain the two catalytic active sites, reside in the large lobes. The SAXS data and amino acid sequence analysis suggest that the Δ1-pyrroline-5-carboxylate dehydrogenase domains lack the conventional oligomerization flap, which is unprecedented for the aldehyde dehydrogenase superfamily. The data also provide insight into the function of the 200-residue C-terminal domain. It is proposed that this domain serves as a lid that covers the internal substrate channeling cavity, thus preventing escape of the catalytic intermediate into the bulk medium. Finally, the SAXS model is consistent with a cloaking mechanism of gene regulation whereby interaction of PutA with the membrane hides the DNA-binding surface from the put regulon thereby activating transcription. PMID:22013066

  2. Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function*

    Science.gov (United States)

    Luo, Min; Gamage, Thameesha T.; Arentson, Benjamin W.; Schlasner, Katherine N.; Becker, Donald F.; Tanner, John J.

    2016-01-01

    Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+-dependent oxidation of aldehydes to carboxylic acids and are important for metabolism and detoxification. Although the ALDH superfamily fold is well established, some ALDHs contain an uncharacterized domain of unknown function (DUF) near the C terminus of the polypeptide chain. Herein, we report the first structure of a protein containing the ALDH superfamily DUF. Proline utilization A from Sinorhizobium meliloti (SmPutA) is a 1233-residue bifunctional enzyme that contains the DUF in addition to proline dehydrogenase and l-glutamate-γ-semialdehyde dehydrogenase catalytic modules. Structures of SmPutA with a proline analog bound to the proline dehydrogenase site and NAD+ bound to the ALDH site were determined in two space groups at 1.7–1.9 Å resolution. The DUF consists of a Rossmann dinucleotide-binding fold fused to a three-stranded β-flap. The Rossmann domain resembles the classic ALDH superfamily NAD+-binding domain, whereas the flap is strikingly similar to the ALDH superfamily dimerization domain. Paradoxically, neither structural element performs its implied function. Electron density maps show that NAD+ does not bind to the DUF Rossmann fold, and small-angle X-ray scattering reveals a novel dimer that has never been seen in the ALDH superfamily. The structure suggests that the DUF is an adapter domain that stabilizes the aldehyde substrate binding loop and seals the substrate-channeling tunnel via tertiary structural interactions that mimic the quaternary structural interactions found in non-DUF PutAs. Kinetic data for SmPutA indicate a substrate-channeling mechanism, in agreement with previous studies of other PutAs. PMID:27679491

  3. Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function.

    Science.gov (United States)

    Luo, Min; Gamage, Thameesha T; Arentson, Benjamin W; Schlasner, Katherine N; Becker, Donald F; Tanner, John J

    2016-11-11

    Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P) + -dependent oxidation of aldehydes to carboxylic acids and are important for metabolism and detoxification. Although the ALDH superfamily fold is well established, some ALDHs contain an uncharacterized domain of unknown function (DUF) near the C terminus of the polypeptide chain. Herein, we report the first structure of a protein containing the ALDH superfamily DUF. Proline utilization A from Sinorhizobium meliloti (SmPutA) is a 1233-residue bifunctional enzyme that contains the DUF in addition to proline dehydrogenase and l-glutamate-γ-semialdehyde dehydrogenase catalytic modules. Structures of SmPutA with a proline analog bound to the proline dehydrogenase site and NAD + bound to the ALDH site were determined in two space groups at 1.7-1.9 Å resolution. The DUF consists of a Rossmann dinucleotide-binding fold fused to a three-stranded β-flap. The Rossmann domain resembles the classic ALDH superfamily NAD + -binding domain, whereas the flap is strikingly similar to the ALDH superfamily dimerization domain. Paradoxically, neither structural element performs its implied function. Electron density maps show that NAD + does not bind to the DUF Rossmann fold, and small-angle X-ray scattering reveals a novel dimer that has never been seen in the ALDH superfamily. The structure suggests that the DUF is an adapter domain that stabilizes the aldehyde substrate binding loop and seals the substrate-channeling tunnel via tertiary structural interactions that mimic the quaternary structural interactions found in non-DUF PutAs. Kinetic data for SmPutA indicate a substrate-channeling mechanism, in agreement with previous studies of other PutAs. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Lifetime prevalence of suicidal ideation among men who have sex with men: a meta-analysis.

    Science.gov (United States)

    Luo, Zhenzhou; Feng, Tiejian; Fu, Hanlin; Yang, Tubao

    2017-12-21

    Suicide is a leading cause of death among men who have sex with men (MSM) and suicidal ideation may put individuals at higher risk of suicide. A great disparity of lifetime prevalence of suicidal ideation among MSM was observed across studies, indicating the importance of a reliable estimation of the pooled lifetime prevalence. However, the only one published meta-analysis estimating the pooled lifetime prevalence of suicidal ideation among MSM was conducted in 2008 with only 2 eligible studies. Subsequently, there was a rapid increase of publications about lifetime suicidal ideation among MSM, suggesting that an update on the pooled lifetime prevalence of suicidal ideation among MSM was necessary. Therefore, this study aimed to update the estimation of the pooled lifetime prevalence of suicidal ideation among MSM. Electronic databases of PubMed, CINAHL, Scopus (social science), Embase and PsycInfo were searched until September 2017 to identify relevant studies. Cross-sectional studies exploring the lifetime prevalence of suicidal ideation among MSM were enrolled. Heterogeneity was evaluated using the Cochran Q test and quantified using the I 2 statistic. The possibility of publication bias was assessed using both Begg's rank test and Egger's linear test, and an Egger's funnel plot for asymmetry was presented. Subgroup analyses were performed according to the geographic area, sample source and HIV status. Nineteen studies with a total of 26,667 MSM were included, of which 9374 were identified with suicidal ideation. A high degree of heterogeneity (P ≤ 0.001, I 2 =99.2%) was observed among the eligible studies, with the reported prevalence ranging from 13.18 to 55.80%. The pooled lifetime prevalence of suicidal ideation among MSM by a random effects model was 34.97% (95% confidence interval: 28.35%-41.90%). Both the Begg's rank test and Egger's linear test indicated low possibility of publication bias. Subgroup analyses showed that the lifetime prevalence of

  5. A case for tolerance in marine ecology: let us not put out the baby with the bathwater

    Directory of Open Access Journals (Sweden)

    Wolf E. Arntz

    2001-12-01

    of science history as well. So tolerance should be the motto: let us not put out the baby with the bathwater! Give the old concepts their credit, look eagerly for alternatives and try to provide the best possible evidence for your results, but be modest. There may be various solutions to one ecological problem, and the way to handle this situation is differentiation, not abolishment.

  6. Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy.

    Science.gov (United States)

    Özdemir, Vural; Kolker, Eugene; Hotez, Peter J; Mohin, Sophie; Prainsack, Barbara; Wynne, Brian; Vayena, Effy; Coşkun, Yavuz; Dereli, Türkay; Huzair, Farah; Borda-Rodriguez, Alexander; Bragazzi, Nicola Luigi; Faris, Jack; Ramesar, Raj; Wonkam, Ambroise; Dandara, Collet; Nair, Bipin; Llerena, Adrián; Kılıç, Koray; Jain, Rekha; Reddy, Panga Jaipal; Gollapalli, Kishore; Srivastava, Sanjeeva; Kickbusch, Ilona

    2014-01-01

    Metadata refer to descriptions about data or as some put it, "data about data." Metadata capture what happens on the backstage of science, on the trajectory from study conception, design, funding, implementation, and analysis to reporting. Definitions of metadata vary, but they can include the context information surrounding the practice of science, or data generated as one uses a technology, including transactional information about the user. As the pursuit of knowledge broadens in the 21(st) century from traditional "science of whats" (data) to include "science of hows" (metadata), we analyze the ways in which metadata serve as a catalyst for responsible and open innovation, and by extension, science diplomacy. In 2015, the United Nations Millennium Development Goals (MDGs) will formally come to an end. Therefore, we propose that metadata, as an ingredient of responsible innovation, can help achieve the Sustainable Development Goals (SDGs) on the post-2015 agenda. Such responsible innovation, as a collective learning process, has become a key component, for example, of the European Union's 80 billion Euro Horizon 2020 R&D Program from 2014-2020. Looking ahead, OMICS: A Journal of Integrative Biology, is launching an initiative for a multi-omics metadata checklist that is flexible yet comprehensive, and will enable more complete utilization of single and multi-omics data sets through data harmonization and greater visibility and accessibility. The generation of metadata that shed light on how omics research is carried out, by whom and under what circumstances, will create an "intervention space" for integration of science with its socio-technical context. This will go a long way to addressing responsible innovation for a fairer and more transparent society. If we believe in science, then such reflexive qualities and commitments attained by availability of omics metadata are preconditions for a robust and socially attuned science, which can then remain broadly

  7. Prevalence of smoking in Cambodia.

    Science.gov (United States)

    Smith, M; Umenai, T; Radford, C

    1998-06-01

    To evaluate the prevalence of cigarette smoking in Cambodia and identify prevailing knowledge, attitudes and practices (KAP). Information on tobacco smoking and KAP was collected using the 30-cluster survey design wherein 10-15 males (age over 15 years) were interviewed from each of 30 randomly-selected population clusters in Phnom Penh (herein referred to as 'urban') and Siem Reap (herein referred to as 'rural') for a total of 601 interviews. Findings show that 65% of urban respondents and 86% of rural respondents smoke. Rural men start smoking at an earlier age, but the average urban smoker spends more. 17% of an urban smoker's personal cash income is spent on tobacco, whereas his rural counterpart spends 8%. This discrepancy is partly due to extensive tobacco brandname promotion in urban areas which has resulted in the average price of a pack of cigarettes being four times higher than that of rural. Other findings show an inverse correlation between incidence of smoking and levels of education/income. Concerning smoking cessation, 66% of urban smokers and 86% of rural smokers interviewed indicated they would attend a program in their area to stop smoking if such a program were available. The high prevalence of smoking in Cambodia, and the health impact it has and will increasingly have on its people is significant. The high cash expenditure for tobacco, especially in urban, is an important factor contributing to Cambodia's impoverished economy. Education, regulatory policies, and smoking cessation are important measures to be considered for effective tobacco control planning and implementation.

  8. [Prevalence of teenage sleeping disorders].

    Science.gov (United States)

    Perdereau-Noël, M; Saliou, P; Vic, P

    2017-04-01

    Teenage sleeping disorders can have short- and long-term consequences such as learning disorders, accidents, depression, and type 2 diabetes. To assess the prevalence of sleeping disorders in high school students in the southwest of Brittany (Finistère), France. To search for family and social factors causing these disorders and drug use. Observational multicenter study that took place in May, 2015, asking high school students to anonymously complete a questionnaire during school time. A variable was created: sleep disorders (TrS+) when teenagers responded "often" or "very often" to at least one of the six questions concerning sleeping disorders. The prevalence of TrS+ was 73 % (4170/5556). These teenagers had difficulty falling asleep (36 %), woke up during the night (33 %), or had nightmares (10 %). Their sleep routine was disrupted (35 %), they did not feel rested the following day (49 %): 9 % were late for class related to their sleeping disorders. TrS+ were more recurrent among females (OR: 2.64; P10 cigarettes per a day) (OR: 2.39; P8h per a day; OR: 2.7; Psleep quality. Ten percent of TrS+ individuals consume medications and 9 % cannabis to help them fall asleep. Technology, drugs, and well-being at school have an impact on sleep quality. Screening of teenagers with sleeping disorders and information programs for teenagers must be provided by the teaching and medical staff. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  9. High Prevalence and Low Awareness of Hypertension in a Market Population in Enugu, Nigeria

    Directory of Open Access Journals (Sweden)

    Ifeoma I. Ulasi

    2011-01-01

    Full Text Available Background. A community-based study put the prevalence of hypertension in Nigeria at 32.8%. Market workers in Nigeria lead sedentary life style and often depend on salt-laden fast food while at work. Method. An unselected population of market workers were screened for hypertension and its risk factors by a pretested, structured questionnaire, clinical examination, and laboratory investigation. Hypertension was defined as BP ≥ 140 and/or ≥ 90 mmHg or being on drug therapy. Results. Forty-two percent of the screened population were hypertensive. Of this number, 70.6% did not know they were hypertensive before the screening. More males than females (=.022 were hypertensive. Prevalence of hypertension increased with age from 5.4% in the age group <20 years to 80% in the age group ≥70 years. Conclusion. The prevalence of hypertension in market workers in this study was 42%, and the majority of them were unaware of their disease.

  10. Interaction between HIV awareness, knowledge, safe sex practice and HIV prevalence: evidence from Botswana.

    Science.gov (United States)

    Ray, Ranjan; Sinha, Kompal

    2012-05-01

    This paper makes methodological and empirical contributions to the study of HIV in the context of Botswana, a country with high HIV prevalence. Comparable evidence is presented from India to put the Botswana results in perspective. The results point to the strong role played by affluence and education in increasing HIV knowledge, promoting safe sex and reducing HIV prevalence. The study presents African evidence on the role played by the empowerment of women in promoting safe sex practices such as condom use. The lack of significant association between HIV prevalence and safe sex practice points to the danger of HIV-infected individuals spreading the disease through multiple sex partners and unprotected sex. This danger is underlined by the finding that females with multiple sex partners are at higher risk of being infected with HIV. These results take on special policy significance in the context of Botswana, where the issue of multiple sex partners has not been adequately addressed in the programme to contain the spread of HIV.

  11. Workplace Violence toward Physicians and Nurses: Prevalence and Correlates in Macau.

    Science.gov (United States)

    Cheung, Teris; Lee, Paul H; Yip, Paul S F

    2017-08-04

    This paper sets out to estimate the prevalence of workplace violence in relation to socio-demographic characteristics of physicians and nurses working in healthcare settings in Macau. Background : Concerted efforts worldwide to reduce workplace violence (WPV) have not yet removed medical-related professionals from the threat of patients', family members', and colleagues' physical and other assaults in Southeast Asia. Methods : The study employs a cross-sectional design to estimate the prevalence and examines the socio-economic and psychological correlates of WPV among medical doctors and nurses in Macau. The data collection period spanned from August to December 2014. Multiple logistic regression examines the prevalence rates of WPV and its associated factors in doctors and nurses. Results : A total of 107 doctors (14.9%) and 613 nurses (85.1%) participated in the study; 57.2% had suffered WPV in the preceding year. The most common forms of workplace violence were verbal abuse (53.4%), physical assault (16.1%), bullying/harassment (14.2%), sexual harassment (4.6%), and racial harassment (2.6%). Most violence was perpetrated by patients and their relatives, colleagues, and supervisors. Conclusions: WPV remains a significant concern in healthcare settings in Macau. Macau's local health authority should consider putting in place a raft of zero-tolerance policies designed to prevent it.

  12. Prevalence and risk factors of child maltreatment among migrant families in China.

    Science.gov (United States)

    Gao, Yunjiao; Atkinson-Sheppard, Sally; Liu, Xing

    2017-03-01

    Although cases of child abuse among migrant families are often reported by social media, the issue of child maltreatment among migrant families in China has received little empirical attention. This study investigated both the prevalence of child maltreatment by parents among migrant families, and the individual, family and community-level risk factors associated with child abuse in this context. A survey was conducted with 667 migrant and 496 local adolescents in Shenzhen, South China, with a stratified two-stage cluster sampling design. Logistic regression analysis was conducted to compare the prevalence of maltreatment between migrant and local adolescents, and also to explore risk factors associated with the psychological and physical maltreatment in both groups. The results showed that parent-to-child abuse was more prevalent among migrant than local adolescents, with migrant adolescents 1.490 and 1.425 times more likely to be psychologically and physically abused by their parents than their local counterparts. Low academic performance, delinquent behavior, family economic adversity and low parent attachment put migrant adolescents at increased risk of both psychological and physical maltreatment, and neighborhood disorganization was significantly related to psychological aggression among migrant adolescents. The findings confirm that child abuse perpetuated by parents is a serious problem in Mainland China, especially among migrant families, and implications for policy and practice are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Valuing call options on single stock futures: Does the put-call parity relationship hold in the South African derivatives market?

    Directory of Open Access Journals (Sweden)

    Biebuyck, A.

    2014-09-01

    Full Text Available Research has shown that violations of put-call parity do occur and that these violations present an investor with opportunities to profit from arbitrage deals. Mispricing may lead to significant superior returns and maximisation of shareholders’ wealth if found and acted upon in a timely manner. This study attempts to determine whether this mispricing of financial derivatives is present in the South African derivatives market. This will be achieved through the valuation of options on single stock futures using the put-call parity relationship. The theoretical fair values obtained, is compared to the actual market values over a period of three years, that is, from 2009 to 2011. The results show that arbitrage opportunities do present themselves for the chosen shares. Further research may involve more shares over a longer period to determine whether any pattern may exist which may form the basis of an arbitrage trading strategy

  14. Analysis of myopia prevalence and influencing factors among primary school students in the urban area of Lanzhou city

    Directory of Open Access Journals (Sweden)

    Ran Zhou

    2014-05-01

    Full Text Available AIM: To understand the prevalence of myopia and to analyze the influencing factors among primary school students in urban area of Lanzhou city, and to provide evidence for prevention and control of myopia. METHODS: Using the cluster random sampling method, 823 students of two primary schools were selected in urban area of Lanzhou city, which were subsequently performed visual and optometry examination and were asked to fill in questionnaires.RESULTS: The prevalence rate of myopia in urban area of Lanzhou city was 41.8%. Individual behavior, the time spent on near-work and outdoor activities were the main influencing factors.CONCLUSION: Primary school should put emphasis on the education of eye caring, and parents should help children distribute the time to reading, entertainment and outdoor activities reasonably, to prevent and slow down the occurrence of myopia.

  15. Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food".

    Science.gov (United States)

    Needham, David; Arslanagic, Amina; Glud, Kasper; Hervella, Pablo; Karimi, Leena; Høeilund-Carlsen, Poul-Flemming; Kinoshita, Koji; Mollenhauer, Jan; Parra, Elisa; Utoft, Anders; Walke, Prasad

    2016-11-01

    The story starts in Basel at CLINAM in 2013, when I asked Pieter about making nanoparticles and he advised me to "try this solvent-exchange method we have developed for making limit sized particles". We are particularly interested in what are "limit size materials" because we want to test the feasibility of an idea: could we design, make, develop, and test the concept for treating metastatic cancer by, "Putting the Drug in the Cancer's Food? "Limit size" is the size of the cancer's food, ? the common Low Density Lipoprotein, (LDL) ~20 nm diameter. In this contribution to Pieter's LTAA we focus on the "bottom" (nucleation) and the "up" (growth) of "bottom-up design" as it applies to homogeneous nucleation of especially, hydrophobic drugs and the 8 physico-chemical stages and associated parameters that determine the initial size, and any subsequent coarsening, of a nanoparticle suspension. We show that, when made by the rapid solvent-exchange method, the same sized particles can be obtained without phospholipid. Furthermore, the obtained size follows the predictions of classic nucleation theory when the appropriate values for the parameters (surface tension and supersaturation) at nucleation are included. Calculations on dissolution time for nanoparticles reveal that a typical fewmicromolar-solubility, hydrophobic, anti-cancer drug (like Lapatinib, Niclosamide, Abiraterone, and Fulvestrant) of 500 nm diameter would take between 3?7 s to dissolve in an infinite sink like the blood stream; and a 50 nm particle would dissolve in less than a second! And so the nanoparticle design requires a highly water-insoluble drug, and a tight, encapsulating, impermeable lipid:cholesterol monolayer. While the "Y" junction can be used to mix an ethanolic solution with anti-solvent, we find that a "no-junction" can give equally good results. A series of nanoparticles (DiI-fluorescently labeled Triolein-cored and drug-cored nanoparticles of Orlistat) were then tested in well

  16. Narrative Review: Sexually Transmitted Diseases and Homeless Youth—What Do We Know About Sexually Transmitted Disease Prevalence and Risk?

    Science.gov (United States)

    Caccamo, Alexandra; Kachur, Rachel; Williams, Samantha P.

    2018-01-01

    Background Homelessness affects an estimated 1.6 million US youth annually. Compared with housed youth, homeless youth are more likely to engage in high-risk behaviors, including inconsistent condom use, multiple sex partners, survival sex, and alcohol/drug use, putting them at increased sexually transmitted disease (STD) risk. However, there is no national estimate of STD prevalence among this population. Methods We identified 10 peer-reviewed articles (9 unique studies) reporting STD prevalence among homeless US youth (2000–2015). Descriptive and qualitative analyses identified STD prevalence ranges and risk factors among youth. Results Eight studies reported specific STD prevalence estimates, mainly chlamydia, gonorrhea, and syphilis. Overall STD prevalence among homeless youth ranged from 6% to 32%. STD rates for girls varied from 16.7% to 46%, and from 9% to 13.1% in boys. Most studies were conducted in the Western United States, with no studies from the Southeast or Northeast. Youths who experienced longer periods of homelessness were more likely to engage in high-risk sexual behaviors. Girls had lower rates of condom use and higher rates of STDs; boys were more likely to engage in anal and anonymous sex. Additionally, peer social networks contributed to protective effects on individual sexual risk behavior. Conclusions Sexually transmitted disease prevalence estimates among homeless youth fluctuated greatly by study. Sexually transmitted disease risk behaviors are associated with unmet survival needs, length of homelessness, and influence of social networks. To promote sexual health and reduce STD rates, we need better estimates of STD prevalence, more geographic diversity of studies, and interventions addressing the behavioral associations identified in our review. PMID:28703725

  17. Narrative Review: Sexually Transmitted Diseases and Homeless Youth-What Do We Know About Sexually Transmitted Disease Prevalence and Risk?

    Science.gov (United States)

    Caccamo, Alexandra; Kachur, Rachel; Williams, Samantha P

    2017-08-01

    Homelessness affects an estimated 1.6 million US youth annually. Compared with housed youth, homeless youth are more likely to engage in high-risk behaviors, including inconsistent condom use, multiple sex partners, survival sex, and alcohol/drug use, putting them at increased sexually transmitted disease (STD) risk. However, there is no national estimate of STD prevalence among this population. We identified 10 peer-reviewed articles (9 unique studies) reporting STD prevalence among homeless US youth (2000-2015). Descriptive and qualitative analyses identified STD prevalence ranges and risk factors among youth. Eight studies reported specific STD prevalence estimates, mainly chlamydia, gonorrhea, and syphilis. Overall STD prevalence among homeless youth ranged from 6% to 32%. STD rates for girls varied from 16.7% to 46%, and from 9% to 13.1% in boys. Most studies were conducted in the Western United States, with no studies from the Southeast or Northeast. Youths who experienced longer periods of homelessness were more likely to engage in high-risk sexual behaviors. Girls had lower rates of condom use and higher rates of STDs; boys were more likely to engage in anal and anonymous sex. Additionally, peer social networks contributed to protective effects on individual sexual risk behavior. Sexually transmitted disease prevalence estimates among homeless youth fluctuated greatly by study. Sexually transmitted disease risk behaviors are associated with unmet survival needs, length of homelessness, and influence of social networks. To promote sexual health and reduce STD rates, we need better estimates of STD prevalence, more geographic diversity of studies, and interventions addressing the behavioral associations identified in our review.

  18. The prevalence of thrombocytopenia in plasmodium falciparum ...

    African Journals Online (AJOL)

    Their platelet counts were evaluated using the auto-analyser Sysmex KX-21N. Results: The overall prevalence of thrombocytopenia was 5.0%, but it was higher in children with severe malaria. None of the children in the control group had thrombocytopenia. Conclusion: The prevalence of thrombocytopenia in falciparum ...

  19. Prevalence of gestrointestinal symptoms in pregnancy | Audu ...

    African Journals Online (AJOL)

    Prevalence of gestrointestinal symptoms in pregnancy. BM Audu, SK Mustapha. Abstract. Objectives: This study is aimed at determining the prevalence of gastrointestinal symptoms among healthy pregnant women attending antenatal clinic at the University of Maiduguri Teaching Hospital. Methods: Questionnaires were ...

  20. Dutch diabetes prevalence estimates (DUDE-1)

    NARCIS (Netherlands)

    Kleefstra, Nanne; Landman, Gijsw. D.; Van Hateren, Kornelis J. J.; Meulepas, Marianne; Romeijnders, Arnold; Rutten, Guy E. H.; Klomp, Maarten; Houweling, Sebastiaan T.; Bilo, Henk J. G.

    2016-01-01

    Background: Recent decades have seen a constant upward projection in the prevalence of diabetes. Attempts to estimate diabetes prevalence rates based on relatively small population samples quite often result in underestimation. The aim of the present study was to investigate whether the Dutch

  1. PREVALENCE AND PREDICTORS OF PREDIABETES AMONG ...

    African Journals Online (AJOL)

    The aim of this study was to find the prevalence of prediabetes and to determine its predictors among administrative staff of ... Conclusion: There was a high prevalence of prediabetes among the administrative staff of University College ..... Riddell M, Fowles J. How to treat prediabetes with exercise effectively. Diabetes 2010 ...

  2. The prevalence of metabolic syndrome components, individually ...

    African Journals Online (AJOL)

    2013-03-19

    Mar 19, 2013 ... 2005; 112: e297 and Circulation. 2005; 112: e298). Circulation. 2005; 112: 2735Б52. 19. Al-Lawati JA, Mohammed AJ, Al-Hinai HQ, Jousilahti P. Prevalence of the metabolic syndrome among Omani adults. Diabetes Care. 2003; 26: 1781Б5. 20. Al-Qahtani DA, Imtiaz ML. Prevalence of metabolic syndrome.

  3. Contraceptive prevalence amongst women attending infant welfare ...

    African Journals Online (AJOL)

    Contraceptive prevalence amongst women attending infant welfare clinic at the University of Port Harcourt Teaching Hospital. ... Abstract. Background: Low contraceptive prevalence in Sub-Sahara Africa has increased the burden of unwanted pregnancies and continued population explosion thus hampering the economic ...

  4. Increased prevalence of migraine in Marfan syndrome

    NARCIS (Netherlands)

    Vis, Jeroen C.; Timmermans, Janneke; Post, Martijn C.; Budts, Werner; Schepens, Marc A. A. M.; Thijs, Vincent; Schonewille, Wouter J.; de Bie, Rob M. A.; Plokker, Herbert W. M.; Tijssen, Jan G. P.; Mulder, Barbara J. M.

    2009-01-01

    OBJECTIVE: A high prevalence of migraine has been described in various forms of congenital heart disease, with and without shunt. In this study we investigated the prevalence of migraine in patients with Marfan syndrome (MFS). METHODS: All 457 adult patients with MFS from the participating centres

  5. Increased prevalence of migraine in Marfan syndrome.

    NARCIS (Netherlands)

    Vis, J.C.; Timmermans, J.; Post, M.C.; Budts, W.; Schepens, M.A.; Thijs, V.; Schonewille, W.J.; Bie, R.M. de; Plokker, H.W.M.; Tijssen, J.G.P.; Mulder, B.J.

    2009-01-01

    OBJECTIVE: A high prevalence of migraine has been described in various forms of congenital heart disease, with and without shunt. In this study we investigated the prevalence of migraine in patients with Marfan syndrome (MFS). METHODS: All 457 adult patients with MFS from the participating centres

  6. Prevalence of Bird Louse, Menacanthus Cornutus (Pthiraptera ...

    African Journals Online (AJOL)

    Study on the prevalence of bird lice in four selected farms in Kano metropolis was conducted to determine the lice species richness, lice abundance and percent prevalence in the four poultry farms. Two hundred and forty (240) birds were examined from four poultry farms within Kano in Tofa, Fagge, Brigade and Gwarzo ...

  7. Prevalence and distribution of Schistosoma haematobium infection ...

    African Journals Online (AJOL)

    Prevalence and distribution of Schistosoma haematobium infection among school children living in southwestern shores of Lake Malawi. ... Methods: This prospective cross-sectional study was conducted in primary schools. School ... Consistent and uniform interventions can reduce prevalence further and sustain control.

  8. Species and prevalence determination of Human Intestinal ...

    African Journals Online (AJOL)

    Intestinal parasitic infections constitute a global health burden causing clinical morbidity. Parasitic protozoa and helminthes are responsible for some of the most devastating and prevalent diseases of human. The study was conducted to determine the prevalence of intestinal parasites among patients attending Federal ...

  9. Prevalence, Progression and Associated Risk Factors of ...

    African Journals Online (AJOL)

    Introduction: The prevalence of peripheral arterial disease (PAD) ranges between 4.5% and 57% and is independently associated with cardiovascular disease burden irrespective of symptoms. Two thirds of cases are thought to be asymptomatic and may go unrecognised. Local prevalence and natural progression of ...

  10. Species and prevalence determination of Human Intestinal ...

    African Journals Online (AJOL)

    ADOWIE PERE

    ABSTRACT: Intestinal parasitic infections constitute a global health burden causing clinical morbidity. Parasitic protozoa and helminthes are responsible for some of the most devastating and prevalent diseases of human. The study was conducted to determine the prevalence of intestinal parasites among patients attending ...

  11. Prevalence of problematic internet use in Slovenia

    Directory of Open Access Journals (Sweden)

    Macur Mirna

    2016-09-01

    Full Text Available Internet use is an integral part of our everyday activities; however, Internet use may become problematic and harmful in a minority of cases. The majority of reported prevalence rates of problematic Internet use refer to adolescent samples, whereas epidemiological studies on representative adult populations are lacking. This study aimed to reveal the prevalence and characteristics of problematic Internet use in Slovenia.

  12. community perceptions of schistosomiasis transmission, prevalence

    African Journals Online (AJOL)

    91 No. 7 July 2014. COMMUNITY PERCEPTIONS OF SCHISTOSOMIASIS TRANSMISSION, PREVALENCE AND CONTROL IN RELATION ... prevalence, transmission and control in relation to aquatic habitats in the Lake Victoria basin of Kenya. .... for Windows software version 12.0 ( SPSS, Atlanta. GA, USA ) for statistical ...

  13. Increased prevalence of hypertension in haemophilia patients

    NARCIS (Netherlands)

    van de Putte, Dietje E. Fransen; Fischer, Kathelijn; Makris, Michael; Tait, R. Campbell; Collins, Peter W.; Meijer, Karina; Roosendaal, Goris; Chowdary, Pratima; Schutgens, Roger E. G.; Mauser-Bunschoten, Eveline P.

    2012-01-01

    An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements

  14. Prevalence of Helicobacter Pylori Infection Among Patients ...

    African Journals Online (AJOL)

    Background: Helicobacter pylori related gastritis is a major health ailment in developing nations. There is high morbidity and mortality ranging from chronic gastritis to gastric malignancies. Prevalence of H. pylori infection varies markedly from country to country and in a country, region to region. Aim: To study the prevalence ...

  15. The Prevalence of Intraventricular Haemorrhage and Associated ...

    African Journals Online (AJOL)

    The Prevalence of Intraventricular Haemorrhage and Associated Risk Factors in Preterm Neonates in the Neonatal Intensive Care Unit at the University Teaching ... any-IVH generated at the time of analysis was used in determining the prevalence of IVH and also as the dependent variable in multivariate logistic regression.

  16. Prevalence of Schistosomiasis in Wurukum, Makurdi Local ...

    African Journals Online (AJOL)

    prevalence 43.3%), while none of those who use pipe borne and bore-hole water exclusively was infected (p < 0.05). Key words: urinary schistosomiasis, prevalence, water sources. Journal of Medical Laboratory Science Vol.12(2) 2003: 47 - 51 ...

  17. Prevalence of Esophageal Adenocarcinoma | Ojuka | Annals of ...

    African Journals Online (AJOL)

    Background: There has been a marked increase of the prevalence of adenocarcinoma of the esophagus across the globe, with the risk factors including gastroesophageal reflux disease (GERD) and Barrett's esophagus. It is not known whether the trend is similar locally. Objective: To describe the prevalence and ...

  18. The prevalence of stalking in the Netherlands

    NARCIS (Netherlands)

    van der Aa, S.; Kunst, M.J.J.

    2009-01-01

    Over eight years after the enactment of the Dutch anti-stalking provisions there are still no figures detailing the prevalence of stalking in The Netherlands. This article aims to estimate the lifetime and annual prevalence of this form of victimization within the Dutch population. Questionnaires

  19. Des tranchées au NSDAP. Culture de guerre et politisation des députés nazis

    Directory of Open Access Journals (Sweden)

    Nicolas Patin

    2011-05-01

    Full Text Available Quel fut le facteur décisif dans l’engagement politique des nazis ? Dans la littérature concernant la Grande Guerre, le conflit est dépeint comme un facteur essentiel : il aurait été créateur d’une “culture de guerre” qui expliquerait en grande partie la mobilisation de beaucoup de nazis. L’analyse de la fraction nationale-socialiste du Reichstag entre 1919 et 1933 ne dément pas ce résultat : elle comptait 80% d’anciens-combattants. Cependant, les autres partis, eux aussi, rassemblaient une proportion énorme de vétérans. Il est possible d’isoler un certain nombre d’attributs spécifiques aux parlementaires nazis, qui, combinées entre eux et avec le poids de l’héritage guerrier, donne une vision plus complexe : si la fraction du NSDAP avait un monopole, ce n’était pas celui de l’expérience guerrière, mais bien de la jeunesse et de l’expérience du front. Ses députés avaient dix ans de moins que les autres parlementaires. Par ailleurs, elle comptait dans ses rangs une proportion plus élevée de militaires de carrière, ou de fils de militaires, ainsi qu’un nombre important d’hommes attachés au monde rural, que ce soit par leur naissance, la profession de leur père ou les études qu’ils choisirent. Tous ces critères permettent de relativiser le poids de la guerre pour établir des profils plus diversifiés d’engagement politique.What was the main reason for German people to join the Nazi Party? In historical literature, First World War has been often depicted as a major explanation: the conflict is supposed to have created a “war culture” that would have led to the political mobilization of many Nazis. An analyze of the national-socialist members of the Reichstag between 1919 and 1933 does not contradict this hypothesis. Indeed, 80% of NSDAP MP’s were war veterans. Nevertheless, in other parties too, an enormous proportion of delegates were veterans. Actually other particularities can

  20. Constipation prevalence in diabetic patients

    Directory of Open Access Journals (Sweden)

    Manoel Álvaro de Freitas Lins Neto

    2014-04-01

    Full Text Available Objective: the aim of this study was to identify the prevalence of constipation in diabetic patients treated at the endocrinology outpatient clinic at Hospital Universitário Professor Alberto Antunes and PAM Salgadinho, from April to August 2013. Methods: a descriptive and cross-sectional study, carried out through a questionnaire using the Rome III criteria in 372 patients treated at the outpatient endocrinology clinic. Results: of 372 patients evaluated, the frequency of constipation found was 31.2% among diabetic patients. Females predominated in the sample (72.8% as well as for the frequency of constipation (80.2%. The incidence of type II diabetes was 97.3% and it was observed that 80.2% of the sample was older than 50 years. One hundred and twelve patients with inadequate glycemic control (HgA1c ≥ 7 had an association with constipation. Conclusion: there was an increased frequency of constipation in patients with diabetes mellitus according to the Rome III criteria, in relation to the general population. The inadequate glycemic control in patients with diabetes mellitus increases the frequency of constipation and it is necessary to perform studies that allow the confirmation of this association to demonstrate this hypothesis. Resumo: Objetivo: analisar a prevalência da constipação intestinal em pacientes diabéticos atendidos no ambulatório de endocrinologia do Hospital Universitário Professor Alberto Antunes e no PAM Salgadinho (HUPAA, de abril de 2013 a agosto 2013. Método: estudo descritivo e transversal, realizado através da aplicação de um questionário com os critérios de Roma III no ambulatório de endocrinologia do HUPAA. Resultado: em 372 pacientes, 271 feminino, 101 masculino, 162 de etnia branca, 55 negros e 155 pardos, 297 pacientes estavam acima de 50 anos, houve uma frequência de constipação de 31,2% nos pacientes diabéticos. O gênero feminino prevaleceu na amostra (73% assim como no índice de frequ

  1. HBV and HIV co-infection: Prevalence and clinical outcomes in tertiary care hospital Malaysia.

    Science.gov (United States)

    Akhtar, Ali; Khan, Amer Hayat; Sulaiman, Syed Azhar Syed; Soo, Chow Ting; Khan, Kashifullah

    2016-03-01

    According to WHO, Malaysia has been classified as a concentrated epidemic country due to progression of HIV infection in the population of injecting drug users. The main objectives of current study are to determine the prevalence of HBV among HIV-positive individuals in a tertiary care hospital of Malaysia and to assess the predictors involved in the outcomes of HIV-HBV co-infected patients. A retrospective, cross-sectional study is conducted at Hospital Palau Pinang, Malaysia. The collection of socio-demographic data as well as clinical data is done with the help of data collection form. Data were analyzed after putting the collected values of required data by using statistical software SPSS version 20.0 and P > 0.05 is considered as significant. Results show that the overall prevalence of HBV was 86 (13%) including 495 (74.5%) males and 169 (25.5%) females among a total of 664 HIV-infected patients. It was observed that there is a high prevalence of HIV-HBV co-infection in males 76 (11.4%) as compared to females 10 (1.5%) (P = 0.002). The median age of the study population was 39 years. The statistical significant risk factors involved in the outcomes of HIV-HBV co-infected patients were observed in the variables of gender, age groups, and injecting drug users. The findings of the present study shows that the prevalence of HBV infection among HIV-positive patients was 13% and the risk factors involved in the outcomes of HIV-HBV co-infected patients were gender, age, and intravenous drug users. © 2015 Wiley Periodicals, Inc.

  2. Intimate partner violence among female drug users admitted to the general hospital: screening and prevalence.

    Science.gov (United States)

    Caldentey, Clara; Tirado Muñoz, Judit; Ferrer, Tessie; Fonseca Casals, Francina; Rossi, Paola; Mestre-Pintó, Juan Ignacio; Torrens Melich, Marta

    2017-06-28

    Intimate partner violence (IPV) is a public health problem worldwide. Several factors have been found to be associated with an increased prevalence of IPV, such as substance use. A cross-sectional study was conducted with the aim of determining the prevalence of IPV among women entering Hospital del Mar (Barcelona) for any medical/surgical reason, and who had a diagnosis of substance use disorder. Secondly, it was intended to psychometrically validate the Spanish version of the Hurt, Insulted, Threatened with Harm, Screamed (HITS) questionnaire. All patients were assessed by two IPV questionnaires, the Composite Abuse Scale (CAS) and HITS. Out of 52 patients interviewed, 46 answered both questionnaires. According to the CAS questionnaire, 23 patients (50%) experienced IPV at some point in their lives and 11 (23.9%) in the last year. Cannabis consumption was also associated with an increased severity of IPV (95% CI 3.5-28.9, p = .013).According to the HITS questionnaire, there was a prevalence of 39.1% (18 patients) in the last 12 months. HITS had a specificity of 100% and a sensitivity of 78% relative to the CAS questionnaire. A cut-off score x∈ [6.7], derived through ROC analysis, correctly discriminated 91% of the victims and 100% of the non-victims. The results obtained showed that the prevalence of IPV was very high among women who suffered from more than one substance use disorder. Therefore, it is highly recommended to systematically screen for IPV victimization by putting the HITS questionnaire into practice.

  3. [Prevalence of malnutrition in Spanish schoolchildren].

    Science.gov (United States)

    Pérez-Ríos, Mónica; Santiago-Pérez, María I; Leis, Rosaura; Malvar, Alberto; Suanzes, Jorge; Hervada, Xurxo

    2017-11-01

    The term malnutrition includes malnutrition due to excess or obesity, underweight as well as stunted growth. Its prevalence in a population can be estimated using anthropometric variables. The aim of this study is to estimate the prevalence of malnutrition in Galician schoolchildren aged 6 to 15years in the school year 2013-2014. A cross-sectional study was conducted on a representative sample by gender and age of the Galician population of 6 to 15years old. The prevalence of obesity, underweight, and short stature was estimated by age and gender using the reference standards proposed by the World Health Organisation. Of the total of 7,438 schoolchildren weighed and measured, 16.4% had malnutrition. The prevalence of obesity was 14.8%, underweight was 0.7%, and short stature for age was estimated at 1%. Obesity was more prevalent among boys. As regards underweight and short stature, when there were differences, prevalence was higher among girls. In Galicia, 16 out of every 100 schoolchildren aged 6 to 15years had malnutrition, with that due to excess or obesity being the most frequent. Prevalence of underweight and short stature did not exceed 1%. This data shows that primary prevention measures should be promoted at an early age to reduce malnutrition due to excess or adiposity, in particular. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  4. Prevalence of fibromyalgia: literature review update.

    Science.gov (United States)

    Marques, Amelia Pasqual; Santo, Adriana de Sousa do Espírito; Berssaneti, Ana Assumpção; Matsutani, Luciana Akemi; Yuan, Susan Lee King

    The present study aimed to update the literature review on the prevalence of fibromyalgia published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of fibromyalgia. Fibromyalgia studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: (A) prevalence of fibromyalgia in the general population; (B) prevalence of fibromyalgia in women; (C) prevalence of fibromyalgia in rural and urban areas; (D) prevalence of fibromyalgia in special populations. The literature shows values of fibromyalgia prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in fibromyalgia prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general. Copyright © 2017 Elsevier Editora Ltda. All rights reserved.

  5. Prevalence of fibromyalgia: literature review update.

    Science.gov (United States)

    Marques, Amelia Pasqual; Santo, Adriana de Sousa do Espírito; Berssaneti, Ana Assumpção; Matsutani, Luciana Akemi; Yuan, Susan Lee King

    2016-12-18

    The present study aimed to update the literature review on the prevalence of fibromyalgia (FM) published in 2006. A bibliographical survey was carried out from 2005 to 2014 in the MEDLINE, Web of Science, Embase, LILACS and SciELO databases and 3274 records were identified. Five researchers selected the studies, following the inclusion criteria: studies that obtained the prevalence of FM. FM studies in associated diseases were excluded. When screening by title and abstract, 2073 irrelevant articles were excluded. The full texts of 210 articles were evaluated for eligibility and this review included 39 studies, described in 41 articles. The selected studies were grouped into four categories: a) prevalence of FM in the general population; B) prevalence of FM in women; C) prevalence of FM in rural and urban areas; D) prevalence of FM in special populations. The literature shows values of FM prevalence in the general population between 0.2 and 6.6%, in women between 2.4 and 6.8%, in urban areas between 0.7 and 11.4%, in rural areas between 0.1 and 5.2%, and in special populations values between 0.6 and 15%. This literature review update shows a significant increase in FM prevalence studies in the world. The new 2010 American College of Rheumatology criteria have not been widely used yet and the COPCORD (Community-oriented program for control of Rheumatic Diseases) methodology has increased the quality of studies on the prevalence of rheumatic diseases in general. Copyright © 2016. Published by Elsevier Editora Ltda.

  6. Childhood obesity, prevalence and prevention

    Directory of Open Access Journals (Sweden)

    Merchant Anwar T

    2005-09-01

    Full Text Available Abstract Childhood obesity has reached epidemic levels in developed countries. Twenty five percent of children in the US are overweight and 11% are obese. Overweight and obesity in childhood are known to have significant impact on both physical and psychological health. The mechanism of obesity development is not fully understood and it is believed to be a disorder with multiple causes. Environmental factors, lifestyle preferences, and cultural environment play pivotal roles in the rising prevalence of obesity worldwide. In general, overweight and obesity are assumed to be the results of an increase in caloric and fat intake. On the other hand, there are supporting evidence that excessive sugar intake by soft drink, increased portion size, and steady decline in physical activity have been playing major roles in the rising rates of obesity all around the world. Consequently, both over-consumption of calories and reduced physical activity are involved in childhood obesity. Almost all researchers agree that prevention could be the key strategy for controlling the current epidemic of obesity. Prevention may include primary prevention of overweight or obesity, secondary prevention or prevention of weight regains following weight loss, and avoidance of more weight increase in obese persons unable to lose weight. Until now, most approaches have focused on changing the behaviour of individuals in diet and exercise. It seems, however, that these strategies have had little impact on the growing increase of the obesity epidemic. While about 50% of the adults are overweight and obese in many countries, it is difficult to reduce excessive weight once it becomes established. Children should therefore be considered the priority population for intervention strategies. Prevention may be achieved through a variety of interventions targeting built environment, physical activity, and diet. Some of these potential strategies for intervention in children can be

  7. Prevalence of workplace bullying and risk groups

    DEFF Research Database (Denmark)

    Ortega, Adriana; Høgh, Annie; Pejtersen, Jan Hyld

    2009-01-01

    OBJECTIVES: To estimate the prevalence of bullying and to identify risk groups in a representative population sample. METHODS: The data for this study was taken from the second Danish Psychosocial Work Environment Study (DPWES). The sample consisted of 3,429 employees between 20 and 59-years....../supervisors the lowest prevalence. People working with things (male-dominated occupations) and people working with clients/patients (female-dominated occupations) reported higher prevalence of bullying than people working with symbols or customers. No significant gender or age differences were found. CONCLUSIONS...

  8. Prevalence and course of pseudothrombocytopenia in outpatients.

    Science.gov (United States)

    Froom, Paul; Barak, Mira

    2011-01-01

    The prevalence and course of pseudothrombocytopenia in outpatients is uncertain. In a cohort study of 687,955 members of a health maintenance organization, we extracted 36,780 consecutive automated complete blood count test results and determined the point prevalence of pseudothrombocytopenia during a one-month period. We also calculated a retrospective cumulative prevalence over the past 5 years. There were 1105 (2.7%) patients with platelet counts of 100-149×10(9)/L and 304 (0.8%) with counts values, or the reference limit value should be lowered to 100×10(9)/L.

  9. “Baba gljive brala” – međimurska svadbena dramska igra kao izvor i put do svetosti praslavenskoga obreda

    OpenAIRE

    Vince Pallua, Jelka

    2013-01-01

    Simbolika rodnosti i plodnosti dobro je poznata i široko rasprostranjena u svadbenim običajima. Cilj je ovog priloga međimursku svadbenu dramsku igru “Baba gljive brala” sagledati u potpuno novome istraživačkom kontekstu u kojemu ta scenska igra nije još bila postavljena – upotrijebiti ju kao dokument agrafi čne kulture, izvor i put prema rekonstrukciji krhotina starijih vjerskih sustava, dotično prema tragovima praslavenske sakralnosti na temelju kojih bi se međimurska svadba mogla povezati ...

  10. Effects of raising frogs and putting pest-killing lamps in paddy fields on the prevention of rice pests and diseases

    Science.gov (United States)

    Teng, Qing; Hu, Xue-Feng; Luo, Fan; Cao, Ming-Yang

    2014-05-01

    Frogs in paddy fields become less and less due to applying large amounts of pesticides and human hunting for a long time, which causes the aggravation of rice pests and diseases. A field experiment was carried out in the suburb of Shanghai to study the effects of artificially raising frogs and putting frequency oscillation pest-killing lamps in paddy fields on the prevention of rice pests and diseases. The field experiment includes three treatments. Treatment I: 150 frogs, each 20 g in weight, per 100 m2 were put in the fields; Treatment II: a frequency oscillation pest-killing lamp was put in the fields; Treatment III: no frogs and pest-killing lamps were put in the fields. All the experimental fields were operated based on the organic faming system. The amount of organic manure, 7500 kg/hm2, was applied to the fields as base fertilizer before sowing in early June, 2013. No any chemical fertilizers and pesticides were used during the entire period of rice growth. Each treatment is in triplicate and each plot is 67 m2 in area. The results are as follows: (1) During the entire growth period, the incidences of rice pests and diseases with Treatment I and II are significantly lower than those with CK (Treatment III). The incidence of chilo suppressalis with Treatment I, II and III is 0, 0.46% and 1.69%, respectively; that of cnaphalocrocis medinalis is 7.67%, 6.62% and 10.10%, respectively; that of rice sheath blight is 0, 11.11% and 5.43%, respectively; that of rice planthopper is 4.25 per hill, 5.75 per hill and 11 per hill, respectively. (2) The grain yield of the three treatments is significantly different. That of Treatment I, II and III is 5157.73 kg/hm2, 4761.60 kg/hm2 and 3645.14kg/hm2 on average, respectively. (3) Affected by frog activities, the contents of NH4-N, available P and available K in the soil with Treatment I are significantly raised. All the above suggest that artificially raising frogs in paddy fields could effectively prevent rice pests and

  11. Prevalence of posttraumatic stress disorder among road traffic accident survivors: A PRISMA-compliant meta-analysis.

    Science.gov (United States)

    Lin, Wanli; Gong, Lina; Xia, Miaojuan; Dai, Wenjie

    2018-01-01

    Involvement in road traffic accidents (RTAs) may put individuals at increased risk for a wide range of psychiatric disorders, among which posttraumatic stress disorder (PTSD) presents a public health issue. However, a great disparity was observed among studies exploring the prevalence of PTSD among RTA survivors. This meta-analysis aimed to explore the pooled prevalence of PTSD among RTA survivors. Electronic databases of PubMed, Embase, Web of Science, PsycARTICLES, PsycINFO, and CINAHL were searched to identify relevant studies. Study selection and data extraction were conducted independently by 2 investigators, and a meta-analysis was performed to synthesize the data. Heterogeneity among studies was evaluated using the Cochran Q test and quantified using the I statistic. Subgroup analyses were performed to identify the source of the heterogeneity. The possibility of publication bias was assessed using Egger linear test. Fifteen eligible studies containing 6804 RTA survivors were identified in this meta-analysis, of which 1489 were identified with PTSD. The pooled prevalence of PTSD among RTA survivors was 22.25% (95% confidence interval: 16.71%-28.33%). A high degree of heterogeneity was observed across studies (I = 97.1%, P < .001), with reported PTSD prevalence ranging from 6.3% to 58.3%. Subgroup analyses found that the prevalence of PTSD among RTA survivors varied significantly across studies in relation to the instrument used to assess PTSD, country, race, gender, and education level (P < .05). The high pooled prevalence of PTSD among RTA survivors found in this study significantly underscores the need for providing timely and effective intervention strategies for RTA survivors. Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

  12. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country

    Directory of Open Access Journals (Sweden)

    Shamlaye C

    2004-03-01

    Full Text Available Abstract Background The prevalence of hyperuricemia has rarely been investigated in developing countries. The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between uric acid levels and the various cardiovascular risk factors in a developing country with high average blood pressures (the Seychelles, Indian Ocean, population mainly of African origin. Methods This cross-sectional health examination survey was based on a population random sample from the Seychelles. It included 1011 subjects aged 25 to 64 years. Blood pressure (BP, body mass index (BMI, waist circumference, waist-to-hip ratio, total and HDL cholesterol, serum triglycerides and serum uric acid were measured. Data were analyzed using scatterplot smoothing techniques and gender-specific linear regression models. Results The prevalence of a serum uric acid level >420 μmol/L in men was 35.2% and the prevalence of a serum uric acid level >360 μmol/L was 8.7% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.73 in men and r = 0.59 in women, p Conclusions This study shows that the prevalence of hyperuricemia can be high in a developing country such as the Seychelles. Besides alcohol consumption and the use of antihypertensive therapy, mainly diuretics, serum uric acid is markedly associated with parameters of the metabolic syndrome, in particular serum triglycerides. Considering the growing incidence of obesity and metabolic syndrome worldwide and the potential link between hyperuricemia and cardiovascular complications, more emphasis should be put on the evolving prevalence of hyperuricemia in developing countries.

  13. Prevalence of urinary schistosomiasis amongst primary school ...

    African Journals Online (AJOL)

    , southwestern Nigeria. ... International Journal of Natural and Applied Sciences ... This investigation was carried out to determine the prevalence of urinary schistosomiasis in selected primary schools in Ado-Ekiti, between June and August ...

  14. Prevalence and characteristics of prostate cancer among ...

    African Journals Online (AJOL)

    Prevalence and characteristics of prostate cancer among participants of a communitybased screening in Nigeria using serum prostate specific antigen and digital rectal examination. SO Ikuerowo, OA Omisanjo, MJ Bioku, MO Ajala, VPN Mordi, JO Esho ...

  15. Prevalence of Helicobacter Pylori Infection Among Patients ...

    African Journals Online (AJOL)

    Conclusion: The prevalence of H. pylori infection is significantly high in rural and suburban population of Ernakulam district, Kerala. Early detection and prompt treatment are essential for prevention of serious complications. Keywords: Gastrointestinal complications, Helicobacter pylori infection, Histopathological ...

  16. Prevalence of Entamoeba histolytica , Giardia lamblia , and ...

    African Journals Online (AJOL)

    Introduction: The intestinal protozoa Entamoeba histolytica, Giardia lamblia, and Cryptosporidium spp. are the causative agents of giardiasis, amebiasis, and cryptosporidiosis, respectively. Adequate knowledge of the geographical distribution of parasites and the demographic variables that influence their prevalence is ...

  17. Investigation into the prevalence and antibacterial susceptibility ...

    African Journals Online (AJOL)

    Investigation into the prevalence and antibacterial susceptibility patterns of aeromonas and plesiomonas species isolated from children with diarrhoea in Amuwo-Odofin and Surulere Local Government areas of Lagos, Nigeria.

  18. Prevalence of Chlamydia Trachomatis Infection among Female ...

    African Journals Online (AJOL)

    Alasia Datonye

    . Nigeria. The aim of this research is to determine the prevalence of and predictive risk factors for Chlamydia trachomatis infection among female undergraduate students of the University of Port Harcourt. Methods: Four hundred undergraduate ...

  19. Prevalence of hyponatremia in palliative care patients

    Directory of Open Access Journals (Sweden)

    Shoba Nair

    2016-01-01

    Conclusions: Prevalence of hyponatremia is significant in palliative care patients. A prospective study looking at the causes and clinical outcomes associated with hyponatremia in palliative care patients is needed.

  20. Prevalence of Brown Dog Tick ( Rhipicephalus Sanguineus ...

    African Journals Online (AJOL)

    79.69%) and young dogs (73.02%) were the least infested animals. The relatively high prevalence of Rhipicephalus sanguineus in the present study suggested that dogs in Lokoja metropolis were of veterinary and public health significance ...

  1. Prevalence of hypertension and prehypertension among children ...

    African Journals Online (AJOL)

    Prevalence of hypertension and prehypertension among children and adolescents in a semi-urban area of Uyo Metropolis, Nigeria. Frances Sam Okpokowuruk, Mkpouto Udeme Akpan, Enobong Emmanuel Ikpeme ...

  2. Dental caries prevalence of medieval Korean people.

    Science.gov (United States)

    Han, Sun Sook; Baek, Kyung-won; Shin, Myung Ho; Kim, Jaehyup; Oh, Chang Seok; Lee, Sang Jun; Shin, Dong Hoon

    2010-07-01

    Prevalence and distribution of dental caries in medieval Korean society were evaluated. Two thousand and nine hundred teeth samples of 126 individuals collected from 16th to 18th century Korean tombs. Preservation status of sample was good. The prevalence of ante- and postmortem tooth loss was 4.4% and 14.2%, respectively. The total caries prevalence was 3.9%. The tooth surface most frequently affected by dental caries was occlusal (4.5%), followed by approximal (2.1%), buccal (1.5%), and lingual (1.1%) surfaces. The prevalence of dental caries in Joseon Dynasty skeleton collection was lower than have been found in other collections of similar chronology. The low consumption of refined sugar in medieval Korean society might be a possible explanation, though the technical limitations inherent in such comparison studies preclude definitive conclusions. 2010 Elsevier Ltd. All rights reserved.

  3. Factors influencing the prevalence of primary dysmenorrhoea ...

    African Journals Online (AJOL)

    2012-02-06

    Factors influencing the prevalence of primary dysmenorrhoea amongst Abia State university medical students, South Eastern Nigeria. ... From February 6, 2012 to February 12, 2012, 132 consenting female medical students completed an anonymous questionnaire administered by research assistants at the hostels.

  4. Prevalence of dementia in Colombian populations

    Directory of Open Access Journals (Sweden)

    Efraín Amaya Vargas

    Full Text Available With the gradual increase in the life expectancy of the population due to scientific progress and public health at the service of society, the prevalence of dementia has been increasing at different rates worldwide. Currently, the prevalence rates range between 5% and 7% (6.4% in the U.S. and up to 8.5 % in Latin America in subjects older than 60 years. The lowest prevalence rate (2.1% has been reported from sub-Saharan Africa, probably due to selective mortality under 60 years of age. By contrast, a very high prevalence of dementia (23.6% dementia in individuals ≥60 years was observed in the city of Neiva, Southern Colombia. We believe that this high rate could be explained by the presence of several risk factors such as very low schooling, low socio-economic strata, chronic diseases, the inclusion of geriatric homes among others, and additional unknown factors.

  5. The localised aggressive periodontitis prevalence in Morocco.

    Science.gov (United States)

    Belhaissi, F E; Cherkaoui, A; Laporte, C; Miquel, J L

    2004-03-01

    This work concerns a retrospective study of prevalence records and the clinical characteristics of localised aggressive periodontitis in the breast of consultants in the periodontitis service in Dental Medicine Faculty of Rabat (Morocco) from 1997 to 1999.

  6. prevalence & characteristics of mothers with multiple pregnancies ...

    African Journals Online (AJOL)

    Vihar

    PREGNANCIES AND ASSOCIATED LABOUR COMPLICATIONS AT. MUHIMBILI NATIONAL HOSPITAL, SEPTEMBER 2005. BY SIKOSANA, MAJID. L. ( MD 4 – 2005/2006). ABSTRACT. Objective: To determine the prevalence & characteristics of mothers with multiple pregnancies and associated labour complications at.

  7. Anthropometric measurements and prevalence of underweight ...

    African Journals Online (AJOL)

    Anthropometric measurements and prevalence of underweight, overweight and obesity in adult Malawians: nationwide population based NCD STEPS survey. ... Introduction: Overweight and obesity are significant causes of increased morbidity and premature mortality from non-communicable diseases, particularly in ...

  8. Prevalence of Wheat Allergy in Japanese Adults

    Directory of Open Access Journals (Sweden)

    Eishin Morita

    2012-01-01

    Conclusions: The prevalence of wheat allergy in Japanese adults was found to be 0.21% by using a combination of questionnaire-based examination, skin prick test and serum omega-5 gliadin-specific IgE test.

  9. Prevalence of vernal keratoconjunctivitis: a rare disease?

    Science.gov (United States)

    Bremond-Gignac, D; Donadieu, J; Leonardi, A; Pouliquen, P; Doan, S; Chiambarretta, F; Montan, P; Milazzo, S; Hoang-Xuan, T; Baudouin, C; Aymé, S

    2008-08-01

    To determine the prevalence of vernal keratoconjuntivitis (VKC) in Europe. A cross-sectional survey was mailed to 3003 ophthalmologists from six countries (Finland, France, Italy, The Netherlands, Norway and Sweden) representing 151.9 million inhabitants. Results were analysed per country, and VKC prevalence for the 15 European member states in 2002 was extrapolated. Six hypotheses were used: disease duration (4 or 8 years) combined with three prevalence hypotheses for non-responding ophthalmologists. The response rate to the survey was 29.5%. The estimates of VKC prevalence in Western Europe (per 10,000 inhabitants) ranged from 1.16 to 10.55. The prevalence of VKC with corneal complications ranged from 0.30 to 2.26. The VKC prevalences per country were in the following ranges: Italy 2.4-27.8, Finland, 0.7-8.4, Sweden 1.2-8.7, The Netherlands 0.6-4.6, France 0.7-3.3 and Norway 0.3-1.9. VKC with corneal complications were: Italy 0.4-4.8, Sweden 0.3-2.4, Finland 0.2-2.8, The Netherlands 0.2-1.6, France 0.3-1.4 and Norway 0.1-1.0. Based on the most likely hypotheses concerning disease duration and non-responding ophthalmologists' VKC case rate, the best estimate of VKC prevalence in Western Europe is 3.2/10,000 inhabitants. The prevalence of VKC with corneal complications is 0.8/10,000 inhabitants.

  10. Diagnosis and prevalence of bacterial vaginosis.

    Directory of Open Access Journals (Sweden)

    Saharan S

    1993-04-01

    Full Text Available A prospective study of 80 women was undertaken to estimate the prevalence of bacterial vaginosis, and to compare two methods of diagnosing the condition. Bacterial Vaginosis was detected by both Gram stain and compound criteria in 30 women. The prevalence was 37.5%. Gram stain provides a simple and inexpensive method for laboratory confirmation of bacterial vaginosis where facilities for using the compound criteria are not available.

  11. Renal Failure Prevalence in Poisoned Patients

    OpenAIRE

    Arefi, Mohammad; Taghaddosinejad, Fakhroddin; Salamaty, Peyman; Soroosh, Davood; Ashraf, Hami; Ebrahimi, Mohsen

    2014-01-01

    Background: Renal failure is an important adverse effect of drug poisoning. Determining the prevalence and etiology of this serious side effect could help us find appropriate strategies for the prevention of renal failure in most affected patients. Objectives: The present study is aimed to identify drugs that induce renal failure and also to find the prevalence of renal failure in patients referred to emergency departments with the chief complaint of drug poisoning, in order to plan better th...

  12. Malaria prevalence in endemic districts of Bangladesh.

    Directory of Open Access Journals (Sweden)

    Ubydul Haque

    Full Text Available BACKGROUND: Following the 1971 ban of DDT in Bangladesh, malaria cases have increased steadily. Malaria persists as a major health problem in the thirteen south-eastern and north-eastern districts of Bangladesh. At present the national malaria control program, largely supported by the Global Fund for AIDS, Tuberculosis and Malaria (GFATM, provides interventions including advocacy at community level, Insecticide Treated Net (ITN distribution, introduction of Rapid Diagnostic Tests (RDT and combination therapy with Coartem. It is imperative, therefore, that baseline data on malaria prevalence and other malaria indicators are collected to assess the effectiveness of the interventions and rationalize the prevention and control efforts. The objective of this study was to obtain this baseline on the prevalence of malaria and bed net use in the thirteen malaria endemic districts of Bangladesh. METHODS AND PRINCIPAL FINDINGS: In 2007, BRAC and ICDDR,B carried out a malaria prevalence survey in thirteen malaria endemic districts of Bangladesh. A multi-stage cluster sampling technique was used and 9750 blood samples were collected. Rapid Diagnostic Tests (RDT were used for the diagnosis of malaria. The weighted average malaria prevalence in the thirteen endemic districts was 3.97%. In five south-eastern districts weighted average malaria prevalence rate was 6.00% and in the eight north-eastern districts weighted average malaria prevalence rate was (0.40%. The highest malaria prevalence was observed in Khagrachari district. The majority of the cases (90.18% were P. falciparum infections. Malaria morbidity rates in five south-eastern districts was 2.94%. In eight north-eastern districts, morbidity was 0.07%. CONCLUSION AND SIGNIFICANCE: Bangladesh has hypoendemic malaria with P. falciparum the dominant parasite species. The malaria situation in the five north-eastern districts of Bangladesh in particular warrants urgent attention. Detailed maps of the

  13. Prevalence of visual impairment in El Salvador: inequalities in educational level and occupational status.

    Science.gov (United States)

    Rius, Anna; Guisasola, Laura; Sabidó, Meritxell; Leasher, Janet L; Moriña, David; Villalobos, Astrid; Lansingh, Van C; Mujica, Oscar J; Rivera-Handal, José Eduardo; Silva, Juan Casrlos

    2014-11-01

    To examine the prevalence of blindness, visual impairment, and related eye diseases and conditions among adults in El Salvador, and to explore socioeconomic inequalities in their prevalence by education level and occupational status, stratified by sex. Based upon the Rapid Assessment of Avoidable Blindness (RAAB) methodology, this nationwide sample comprised 3 800 participants (3 399 examined) ≥ 50 years old from 76 randomly selected clusters of 50 persons each. The prevalence of blindness, visual impairment and related eye diseases and conditions, including uncorrected refractive error (URE), was calculated for categories of education level and occupational status. Multiple logistic regression models were fitted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) and stratified by sex. Age-adjusted prevalence was 2.4% (95% CI: 2.2-2.6) for blindness (men: 2.8% (95% CI: 2.5-3.1); women: 2.2% (95% CI: 1.9-2.5)) and 11.8% (95% CI: 11.6-12.0) for moderate visual impairment (men: 10.8% (95% CI: 10.5-11.1); women: 12.6% (95% CI: 12.4-12.8)). The proportion of visual impairment due to cataract was 43.8% in men and 33.5% in women. Inverse gradients of socioeconomic inequalities were observed in the prevalence of visual impairment. For example, the age-adjusted OR (AOR) was 3.4 (95% CI: 2.0-6.4) for visual impairment and 4.3 (95% CI: 2.1-10.4) for related URE in illiterate women compared to those with secondary education, and 1.9 (95% CI: 1.1-3.1) in cataract in unemployed men. Blindness and visual impairment prevalence is high in the El Salvador adult population. The main associated conditions are cataract and URE, two treatable conditions. As socioeconomic and gender inequalities in ocular health may herald discrimination and important barriers to accessing affordable, good-quality, and timely health care services, prioritization of public eye health care and disability policies should be put in place, particularly among women, the unemployed, and

  14. Prevalence of visual impairment in El Salvador: inequalities in educational level and occupational status

    Directory of Open Access Journals (Sweden)

    Anna Rius

    2014-11-01

    Full Text Available OBJECTIVE: To examine the prevalence of blindness, visual impairment, and related eye diseases and conditions among adults in El Salvador, and to explore socioeconomic inequalities in their prevalence by education level and occupational status, stratified by sex. METHODS: Based upon the Rapid Assessment of Avoidable Blindness (RAAB methodology, this nationwide sample comprised 3 800 participants (3 399 examined ≥ 50 years old from 76 randomly selected clusters of 50 persons each. The prevalence of blindness, visual impairment and related eye diseases and conditions, including uncorrected refractive error (URE, was calculated for categories of education level and occupational status. Multiple logistic regression models were fitted to calculate odds ratios (ORs and 95% confidence intervals (CIs and stratified by sex. RESULTS: Age-adjusted prevalence was 2.4% (95% CI: 2.2-2.6 for blindness (men: 2.8% (95% CI: 2.5-3.1; women: 2.2% (95% CI: 1.9-2.5 and 11.8% (95% CI: 11.6-12.0 for moderate visual impairment (men: 10.8% (95% CI: 10.5-11.1; women: 12.6% (95% CI: 12.4-12.8. The proportion of visual impairment due to cataract was 43.8% in men and 33.5% in women. Inverse gradients of socioeconomic inequalities were observed in the prevalence of visual impairment. For example, the age-adjusted OR (AOR was 3.4 (95% CI: 2.0-6.4 for visual impairment and 4.3 (95% CI: 2.1-10.4 for related URE in illiterate women compared to those with secondary education, and 1.9 (95% CI: 1.1-3.1 in cataract in unemployed men. CONCLUSIONS: Blindness and visual impairment prevalence is high in the El Salvador adult population. The main associated conditions are cataract and URE, two treatable conditions. As socioeconomic and gender inequalities in ocular health may herald discrimination and important barriers to accessing affordable, good-quality, and timely health care services, prioritization of public eye health care and disability policies should be put in place

  15. Increasing Prevalence, Changes in Diagnostic Criteria, and Nutritional Risk Factors for Autism Spectrum Disorders

    Science.gov (United States)

    Neggers, Yasmin H.

    2014-01-01

    The frequency of autism spectrum disorders (ASD) diagnoses has been increasing for decades, but researchers cannot agree on whether the trend is a result of increased awareness, improved detection, expanding definition, or an actual increase in incidence or a combination of these factors. Though both genetic and multiple environmental risk factors have been studied extensively, many potentially modifiable risk factors including nutritional and immune function related risk factors such as vitamin D, folic acid, and metabolic syndrome have not received sufficient attention. Several recent studies have put forward hypotheses to explain the mechanism of association between both folic acid and vitamin D and autism. A continuous rise in the prevalence of autism in the USA has coincided with a significant enhancement of maternal folate status with FDA mandated folic acid fortification of certain foods starting in 1998. There is also a growing body of research that suggests that vitamin D status either in utero or early in life may be a risk for autism. In this communication, controversies regarding increase in estimate of prevalence, implications of changes in definition, and possible association between some modifiable nutritional risk factors such as folic acid and vitamin D and ASD will be discussed. PMID:24967269

  16. Prevalence of oppositional defiant disorder in Spain.

    Science.gov (United States)

    López-Villalobos, José Antonio; Andrés-De Llano, Jesús María; Rodríguez-Molinero, Luis; Garrido-Redondo, Mercedes; Sacristán-Martín, Ana María; Martínez-Rivera, María Teresa; Alberola-López, Susana; Sánchez-Azón, María Isabel

    2014-01-01

    Oppositional defiant disorder (ODD) is characterized by a pattern of negative, defiant, disobedient and hostile behavior toward authority figures. ODD is one of the most frequent reasons for clinical consultation on mental health during childhood and adolescence. ODD has a high morbidity and dysfunction, and has important implications for the future if not treated early. To determine the prevalence of ODD in schoolchildren aged 6-16 years in Castile and Leon (Spain). Population study with a stratified multistage sample, and a proportional cluster design. Sample analyzed: 1,049. Cases were defined according to DSM-IV criteria. An overall prevalence rate of 5.6% was found (95% CI: 4.2%-7%). Male gender prevalence=6.8%; female=4.3%. Prevalence in secondary education=6.2%; primary education=5.3%. No significant differences by gender, age, grade, type of school, or demographic area were found. ODD prevalence without considering functional impairment, such as is performed in some research, would increase the prevalence to 7.4%. ODD cases have significantly worse academic outcomes (overall academic performance, reading, maths and writing), and worse classroom behavior (relationship with peers, respect for rules, organizational skills, academic tasks, and disruption of the class). Castile and Leon has a prevalence rate of ODD slightly higher to that observed in international publications. Depending on the distribution by age, morbidity and clinical dysfunctional impact, an early diagnosis and a preventive intervention are required for health planning. Copyright © 2013 SEP y SEPB. Published by Elsevier España. All rights reserved.

  17. Back pain prevalence in adolescent athletes.

    Science.gov (United States)

    Müller, J; Müller, S; Stoll, J; Fröhlich, K; Otto, C; Mayer, F

    2017-04-01

    The research aimed to investigate back pain (BP) prevalence in a large cohort of young athletes with respect to age, gender, and sport discipline. BP (within the last 7 days) was assessed with a face scale (face 1-2 = no pain; face 3-5 = pain) in 2116 athletes (m/f 61%/39%; 13.3 ± 1.7 years; 163.0 ± 11.8 cm; 52.6 ± 13.9 kg; 4.9 ± 2.7 training years; 8.4 ± 5.7 training h/week). Four different sports categories were devised (a: combat sports, b: game sports; c: explosive strength sport; d: endurance sport). Analysis was described descriptively, regarding age, gender, and sport. In addition, 95% confidence intervals (CI) were calculated. About 168 (8%) athletes were allocated into the BP group. About 9% of females and 7% of males reported BP. Athletes, 11-13 years, showed a prevalence of 2-4%; while prevalence increased to 12-20% in 14- to 17-year olds. Considering sport discipline, prevalence ranged from 3% (soccer) to 14% (canoeing). Prevalences in weight lifting, judo, wrestling, rowing, and shooting were ≥10%; in boxing, soccer, handball, cycling, and horse riding, ≤6%. 95% CI ranged between 0.08-0.11. BP exists in adolescent athletes, but is uncommon and shows no gender differences. A prevalence increase after age 14 is obvious. Differentiated prevention programs in daily training routines might address sport discipline-specific BP prevalence. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Prevalence of asthma in college student population

    Directory of Open Access Journals (Sweden)

    Stojanović-Ristić Snežana

    2006-01-01

    Full Text Available Introduction: Bronchial asthma is common chronic disease among young people and prevalence of this condition has been constantly growing over past two decades throughout the world. Objective: To establish the prevalence of asthma in student population of Belgrade University and to determine the frequency distribution in regard to their permanent residence. Method: Data obtained from annual physical examinations of 118 342 students (age 19-23 years treated at the Student’s Health Care Institute between 1996-2001 were analyzed. Affirmative answer to the question: "Are you currently treated", or "Have you ever been treated for asthma" indicated diagnosis of asthma. Data on student’s age, gender, permanent residence, and smoking habits were collected. Results: The prevalence of asthma was 3680/100.000 and mildly growing trend was noted over the last several years (from 2.96% to 4.05% (F=42.427; df=4; p<0.01. Asthma was more prevalent in females (57% than among males (43% (χ2=91.189; df=1; p<0.01. Several regions with increased asthma incidence were identified and the causes of such findings still need to be clarified. Cigarette smoking was common in students (χ2=236.781; df=1; p<0.01, but also among asthmatics [one out of three students was a smoker (χ2=8.141; df=1; p<0.01]. Conclusion: The prevalence of asthma in student population is 3.68% with mildly growing trend over the last years. The disease is more prevalent in females. Cigarette smoking is common in students as well as among asthmatics. To our knowledge, this is the first study on prevalence of asthma in young adult population in our country.

  19. Prevalence of hyperhidrosis among medical students.

    Science.gov (United States)

    Westphal, Fernando Luiz; de Carvalho, Maria Auxiliadora Neves; Lima, Luiz Carlos; de Carvalho, Bruna Cecília Neves; Padilla, Rodrigo; Araújo, Katiúscia Karla Lêdo

    2011-01-01

    To identify the prevalence of hyperhidrosis among medical students of Manaus, State of Amazonas, Brazil. We conducted an observational, transversal, survey which examined the prevalence of primary hyperhidrosis among medical students of the Federal University of Amazonas and its relation to body mass index (BMI) and stress. Students were weighed and interviewed. We used questionnaires with questions recommended by the International Hyperhidrosis Society to relate hyperhidrosis to the daily activities of each person. Results were given by calculating the prevalence ratios and confidence intervals. Among the 293 students examined, it was found that a total of 16 (5.5%) students had barely tolerable or intolerable excessive sweating, interfering with daily activities. None had known causes of hyperhidrosis and 50% had family history. In all suffering from the condition the disease was bilateral, the mainly affected locations being: hands (35.7%), legs (21.4%), axilla (17.9), face (10 7%), back (7.1%), chest (3.6%) and abdomen (3.6%). There was no predominance regarding gender, age or BMI. We found a positive relationship with BMI and observed a prevalence ratio of 2.48 higher in overweight students than in normal weight or underweight ones. The prevalence of primary hyperhidrosis among medical students of Manaus was 5.5%. There is a positive non-statistical relationship with overweight and obesity. It was further noted an observational relationship with stress.

  20. [Prevalence of metabolic syndrome in elderly patients].

    Science.gov (United States)

    Castro Vilela, María Elena; Quílez Pina, Raquel María; Bonafonte Marteles, José Luis; Morlanes Navarro, Teresa; Calvo Gracia, Fernando

    2014-01-01

    To determine the prevalence of metabolic syndrome (MS) according to the definitions of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation (IDF) and its relation to cardiovascular disease (CVD) in hospitalized elderly patients. This descriptive and prospective study (February-March 2011) included 200 consecutive patients hospitalized in a Geriatric Department. Sociodemographic, clinical and biochemical data was collected. The prevalence of MS was 65% (NCEP-ATP III) and 67.5% (IDF) and was greater in women (NCEP-ATP III=72.8%, IDF=73.6%) than in men (NCEP-ATP III=50.7%; IDF=56.3%). The mean age of patients diagnosed with MS by both diagnostic criteria were similar: 84.7 years. MS was not associated with an increased prevalence of CVD. MS is highly prevalent in elderly hospitalized patients, being higher in women, with both diagnostic criteria (NCEP- ATP III and IDF). In our population the MS was not associated with an increased prevalence of CVD. Copyright © 2013 SEGG. Published by Elsevier Espana. All rights reserved.

  1. Prevalence of hyperhomocysteinemia in healthy Indian doctors

    Science.gov (United States)

    Kamdi, Sandesh P; Palkar, Prashant

    2013-01-01

    Currently, hyperhomocysteinemia is a well-known risk factor for variety of vascular diseases. Prevalence of hyperhomocysteinemia increases with age. Hence, the present study was aimed to investigate the prevalence of hyperhomocysteinemia in healthy upper socio-economic class population in India. Total homocysteine (tHcy) concentration was determined in 1243 (906 men & 337 women) healthy Indian doctors with different age group. Using Third National Health and Nutrition Examination Survey (NHANES III) study criteria, the prevalence of hyperhomocysteinemia was 92.85% among men (>11.4 µmol/L) and 81.60% among women (>10.4 µmol/L). The prevalence of hyperhomocysteinemia was higher among men with mean tHcy concentration (21.96 ± 0.38 µmol/L) significantly higher (P<0.0001) than women (15.90 ± 0.39 µmol/L) (95% CI, 4.733- 7.376). Our study showed very high prevalence of hyperhomocysteinemia which may point to the future risk for various pathologies in the present subset of population. Further studies to look at the plasma levels of homocysteine lowering vitamins are warranted to prevent the future risk of vascular diseases. PMID:23519236

  2. Prevalence of Listeria monocytogenes in European cheeses

    DEFF Research Database (Denmark)

    Martinez Rios, Veronica; Dalgaard, Paw

    2017-01-01

    Both in Europe and worldwide cheese has caused important outbreaks of listeriosis and can be a vehicle for transmission of Listeria monocytogenes to consumers. A systematic review and meta-analysis were conducted using scientific literature and European Food Safety Authority (EFSA) reports...... to summarize available data on the prevalence of L. monocytogenes in different types of cheeses produced in Europe. Meta-analysis models were used to estimate mean prevalence of the pathogen and to compare prevalence among types of cheeses (fresh, ripened, veined, smear and brined) and cheeses produced using.......5-1.1%). The prevalence differed among types of cheeses including fresh (0.8%; CI: 0.3-1.9%), ripened (2.0%; CI: 0.8-4.9%), veined (2.4%; CI: 0.9-6.3%), smear (5.1%; CI: 1.9-13.1%) and brined (11.8%; CI: 3.5-33.3%). Mean prevalence of L. monocytogenes in soft/semi-soft cheeses were not significantly different (P > 0...

  3. Prevalence of genetic renal disease in children.

    Science.gov (United States)

    Fletcher, Jeffery; McDonald, Stephen; Alexander, Stephen I

    2013-02-01

    Genetic etiology comprises a significant proportion of renal disease in childhood. Completion of the Human Genome Project and increased genetic testing has assisted with the increased recognition of a genetic basis to many renal disorders. Australia and New Zealand have a relatively stable but diverse population, with eight major pediatric nephrology referral centers, which allow ascertainment of disease frequency. To determine prevalence, pediatric nephrologists at the eight centers in Australia and New Zealand were surveyed on their estimated number of patients with renal disease of genetic etiology over a 10-year period. Disease prevalence was calculated using combined national population data. The overall prevalence of genetic kidney disease in children in Australia and New Zealand is 70.6 children per million age-representative population. Congenital anomalies of the kidney and urinary tract (CAKUT) and steroid-resistant nephrotic syndrome (SRNS) are the most frequent, with a prevalence of 16.3 and 10.7, respectively, per million children. We find a similar prevalence of genetic renal disorders in Australia and New Zealand to those reported in other countries. This is likely to be due to inclusion of children with all forms of renal disease rather than being limited to those with renal impairment.

  4. Prevalence of food allergies in South Asia.

    Science.gov (United States)

    Arakali, Schweta R; Green, Todd D; Dinakar, Chitra

    2017-01-01

    To evaluate the published medical literature on the prevalence and types of food allergies in South Asia. A PubMed search was performed using the keywords India and food allergy, Asia and food allergy, and South Asia and food allergy for any period. Articles cited in selected studies were reviewed for their appropriateness of inclusion into this review. Publications were included that were original research and fit the topic of food allergy and South Asia. South Asia is defined as region inclusive of India, Pakistan, Bangladesh, and Sri Lanka. A total of 169 articles were initially identified, and 47 were reviewed in detail for inclusion in this review. The primary focus was placed on 10 studies that consisted of case reports of newly reported or documented food allergy, survey studies that investigated food allergy prevalence in specific demographics, and prospective and cross-sectional studies with case controls, all of which investigated food allergy prevalence by allergy testing in a selected population. The medical literature on the prevalence and types of food allergy in South Asia indicates that there is a variety of unusual and unique allergens and an overall low incidence of food allergy. There is also an association of increased food allergy prevalence in individuals who live in metropolitan regions or who migrate to communities that have adopted westernization. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  5. Prevalence and Risk Factors of Caregiver Dependence among Older Adults in a Southeast Asian Population.

    Science.gov (United States)

    Picco, Louisa; Abdin, Edimansyah; Vaingankar, Janhavi A; Pang, Shirlene; Shafie, Saleha; Sambasivam, Rajeswari; Chong, Siow Ann; Subramaniam, Mythily

    2016-11-01

    Currently very little is known about the prevalence or magnitude of caregiver dependence in Singapore and thus, there is a need to fill this gap in this multiethnic ageing population. This study aims to determine the prevalence and risk factors of caregiver dependence among older adults in Singapore. Data were used from the Well-being of the Singapore Elderly (WiSE) study, a nationally representative, cross-sectional survey among Singapore residents aged 60 years and above. Caregiver dependence was ascertained by asking the informant (the person who knows the older person best) a series of open-ended questions about the older person's care needs. The older adult sample comprised 57.1% females and the majority were aged 60 to 74 years (74.8%), while 19.5% were 75 to 84 years, and 5.7% were 85 years and above. The prevalence of caregiver dependence was 17.2% among older adults. Significant sociodemographic risk factors of caregiver dependence included older age (75 to 84 years, and 85 years and above, P dementia ( P cough ( P = 0.016), paralysis ( P <0.001), asthma ( P = 0.016) and cancer ( P = 0.026) were significantly associated with caregiver dependence. Various sociodemographic and health-related conditions were significantly associated with caregiver dependence. Dependent older adults will put greater demands on health and social services, resulting in greater healthcare expenditures. Hence, effective planning, services and support are crucial to meet the needs of dependent older adults and their caregivers.

  6. A comparative study of the spatial distribution of HIV prevalence in the metropolis of Kermanshah, Iran, in 1996-2014 using geographical information systems.

    Science.gov (United States)

    Khademi, N; Reshadat, S; Zangeneh, A; Saeidi, S; Ghasemi, S R; Rajabi-Gilan, N; Zakiei, A

    2017-03-01

    Geographical information systems (GISs) have made spatiotemporal understanding of geographical patterns possible and have contributed to the identification and analysis of factors relating to health care behaviours and outcomes. The present study is the first to examine the spatial distribution of HIV prevalence in the metropolis of Kermanshah, Iran, using GISs. The research methods were descriptive, analytical and comparative. Additionally, data recorded for HIV-infected patients in 1996-2014 were used and then the loci of HIV infection in the metropolis of Kermanshah were identified and analysed spatially using ArcGIS (Esri, New York, NY, USA). HIV prevalence in the metropolis of Kermanshah increased from 1996 to 2014. Analysis of the spatial distribution of the prevalence of HIV using ArcGIS indicated the presence of clusters of HIV infection. The findings demonstrate that there were many clusters of high HIV prevalence throughout the city of Kermanshah and that these clusters increased in size during the study period. Furthermore, the statistics are indicative of a growing number of HIV-infected women as well as a significant reduction in the mean age of the HIV-infected female population. The spatial differences in HIV prevalence across the city of Kermanshah, as well as the identification of the resulting spatial clusters in different parts of the city, suggest that measures should be put in place to prevent the growth of these clusters and to reduce the number of women being infected with HIV. © 2016 British HIV Association.

  7. Prevalence of maternal chronic diseases during pregnancy

    DEFF Research Database (Denmark)

    Jølving, Line Riis; Nielsen, Jan; Kesmodel, Ulrik Schiøler

    2016-01-01

    INTRODUCTION: There is substantial evidence of a negative impact of maternal chronic disease during pregnancy on reproductive outcomes. Knowledge of the prevalence of chronic diseases during pregnancy is limited, but essential for a focused preventive effort regarding optimal disease control during...... pregnancy. We aimed to analyze the prevalence of chronic diseases during pregnancy. MATERIAL AND METHODS: This register-based cohort study included all women giving birth in Denmark between 1989 and 2013 based on data from Danish health registers. Maternal chronic diseases included 23 disease categories...... of both physical and mental health conditions recorded within a period of 10 years before childbirth. RESULTS: We included 1 362 200 childbirths during the study period. The overall prevalence of maternal chronic disease increased from 3.71% in 1989 to 15.76% in 2013. The most frequently registered...

  8. Prevalence of generalized retinal dystrophy in Denmark

    DEFF Research Database (Denmark)

    Bertelsen, Mette; Jensen, Hanne; Bregnhøj, Jesper F

    2014-01-01

    of this study was to examine the prevalence and diagnostic spectrum of generalized retinal dystrophy in the Danish population. METHODS: A population-based cross-sectional study with data from the Danish Retinitis Pigmentosa Registry that comprises all patients in Denmark with generalized retinal....... RESULTS: Of the 5,602,628 Danish citizens on January 1, 2013, 1622 patients were registered as having a generalized retinal dystrophy and were alive and living in Denmark, corresponding to a prevalence of 1:3,454. In 28% of cases the eye condition was part of a syndrome, while the remaining 72% had eye...... disease only. Aside from simplex cases (45%), the most common hereditary pattern was autosomal recessive (23%). CONCLUSION: This epidemiological survey demonstrates that the prevalence of generalized retinal dystrophy in the Danish population is 1:3454. Many of the dystrophies are the subjects of clinical...

  9. Prevalence of burnout among musculoskeletal radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Chew, Felix S.; Porrino, Jack A.; Mulcahy, Hyojeong; Relyea-Chew, Annemarie [University of Washington, Department of Radiology, Seattle, WA (United States); Mulcahy, Michael J. [Central Washington University, Department of Sociology, Ellensburg, WA (United States)

    2017-04-15

    Burnout is a job-related psychological syndrome with three aspects: emotional exhaustion, depersonalization, and perceived lack of personal accomplishment. Burnout is associated with deleterious effects on both workers and their work. When burnout affects physicians, their well-being, longevity, and care of patients are at risk. Recent studies concerning physician burnout treat specialists such as radiologists as one group. We studied burnout in musculoskeletal (MSK) subspecialist radiologists. An institutional review board exemption was obtained. Society of Skeletal Radiology members received invitations to an anonymous survey that included questions from the Maslach Burnout Inventory trademark (MBI) measuring all three aspects of burnout. The response rate was 36.4% (433/1190). The prevalence of emotional exhaustion was 61.7% (255/413), of depersonalization 53.3% (219/411), and of perceived lack of personal accomplishment 39.6% (161/407). Only 19.5% (79/405) of MSK radiologists reported no burnout, while 80.5% (326/405) reported burnout along one or more dimensions. For all three dimensions, the prevalence was higher and the mean severity was worse for private practice compared with academic practice. The prevalence of burnout was affected more by practice setting than by gender. Burnout prevalence and severity also varied systematically with years since completion of training. Among MSK radiologists, we found a much higher prevalence and greater severity of burnout than has been previously reported for radiologists and other physicians. There were differences in prevalence and severity of burnout among practice settings, genders, and longevity cohorts. (orig.)

  10. Prevalence of burnout among musculoskeletal radiologists

    International Nuclear Information System (INIS)

    Chew, Felix S.; Porrino, Jack A.; Mulcahy, Hyojeong; Relyea-Chew, Annemarie; Mulcahy, Michael J.

    2017-01-01

    Burnout is a job-related psychological syndrome with three aspects: emotional exhaustion, depersonalization, and perceived lack of personal accomplishment. Burnout is associated with deleterious effects on both workers and their work. When burnout affects physicians, their well-being, longevity, and care of patients are at risk. Recent studies concerning physician burnout treat specialists such as radiologists as one group. We studied burnout in musculoskeletal (MSK) subspecialist radiologists. An institutional review board exemption was obtained. Society of Skeletal Radiology members received invitations to an anonymous survey that included questions from the Maslach Burnout Inventory trademark (MBI) measuring all three aspects of burnout. The response rate was 36.4% (433/1190). The prevalence of emotional exhaustion was 61.7% (255/413), of depersonalization 53.3% (219/411), and of perceived lack of personal accomplishment 39.6% (161/407). Only 19.5% (79/405) of MSK radiologists reported no burnout, while 80.5% (326/405) reported burnout along one or more dimensions. For all three dimensions, the prevalence was higher and the mean severity was worse for private practice compared with academic practice. The prevalence of burnout was affected more by practice setting than by gender. Burnout prevalence and severity also varied systematically with years since completion of training. Among MSK radiologists, we found a much higher prevalence and greater severity of burnout than has been previously reported for radiologists and other physicians. There were differences in prevalence and severity of burnout among practice settings, genders, and longevity cohorts. (orig.)

  11. [Prevalence of arterial hypertension in Cushing's syndrome].

    Science.gov (United States)

    Rodrigues, D; Barros, L; Ruas, L; Gomes, L; Geraldes, E; Ruas, M C

    1997-11-01

    To determine the prevalence of hypertension (HT) in patients with Cushing's syndrome. We studied 23 patients with Cushing's syndrome, 17 women (mean +/- SD age = 42.8 +/- 15.6 years) and 6 men (mean +/- SD age = 34.8 +/- 10.2 years). The etiologies were: 16-Cushing's disease, 3-suprarenal adenoma, 2-suprarenal carcinoma and 2-iatrogenic. Blood pressure (BP) was measured at least three times and we consider hypertension when systolic BP > or = 140 mmHg and/or diastolic BP > or = 90 mmHg. The prevalence of HT, at diagnosis, was 73.9% (64.7% in women and 100% in men) and the mean BP was 163 +/- 25/100 +/- 16 mmHg (158 +/- 26/97 +/- 15 mmHg in women and 182 +/- 5/114 +/- 10 mmHg in men). From the 16 patients with Cushing's disease, 13 (81%) had HT; all the patients (n = 3) with suprarenal adenoma had HT; none with suprarenal carcinoma (n = 2) had HT and only 1 of the 2 patients with iatrogenic Cushing's syndrome had HT. After treatment, 14 patients entered remission, 6 persisted with active disease and 1 was missed during the follow-up. In the group of patients that entered remission, the prevalence of HT at diagnosis was 78.5% (n = 11), 57.1% (n = 8) being after treatment. In this study, we found a high prevalence of HT at diagnosis (73.9%). After treatment and in the patients that entered remission, the prevalence of HT remained high (78.5% vs 57.1%). The high prevalence of HT in Cushing's syndrome, suggests its importance as a morbidity factor and also as an important diagnostic indicator, when present.

  12. Report of the work group on modalities of selling and putting up for auction CO2 emission permits in France. Elements related to phase 3

    International Nuclear Information System (INIS)

    2009-01-01

    The first part of this report shows that, despite recurring critics on the current emission permit price, the European market kept on maturing and proved its ability to reflect the evolution of fundamentals into prices. The second part shows that recent foreign experiences in putting up for auction CO 2 emission permits revealed convergencies as far as auction formats are concerned. The third part shows that the economic theory and these empirical experimental results support the idea of uniform auctions with a unique price accompanied with a reserved price. It discusses the evolution perspectives of these sales by auction, outlines that access to auctions should be opened to all industrial and financial actors, and the importance of the modalities of control and regulation of the emission permit market. It finally outlines and discusses the role France could play in the building up of a European platform and in the promotion of strictly harmonised rules

  13. NASA puts JWST Back on Track, but ExoMars Collaboration Looks Unlikely; Marsquakes happening yesterday, geologically; UFOs from black holes control shape of galaxies

    Science.gov (United States)

    2012-04-01

    NASA's funding plans put the James Webb Space Telescope firmly on track for a launch in 2018, to widespread relief, but the essentially flat funding settlement for 2013 overall means something has to go. Planetary science seems hardest hit, with the especial blow for European planetary scientists of NASA pulling out of ExoMars, the ESA-led mission to look for signs of life on Mars. Images from the High Resolution Imaging Science Experiment have shown boulders displaced by seismic activity on Mars in the past few million years, and possibly much more recently than that. The bigger the supermassive black hole at the centre of a galaxy, the faster the stars in the galactic bulge rotate. Why this should be so has been something of a puzzle, but now a mechanism that is both powerful and common enough to do the job has been identified.

  14. News and Views: NASA puts JWST back on track, but ExoMars collaboration looks unlikely; Marsquakes happening yesterday, geologically; UFOs from black holes control shape of galaxies

    Science.gov (United States)

    2012-04-01

    NASA's funding plans put the James Webb Space Telescope firmly on track for a launch in 2018, to widespread relief, but the essentially flat funding settlement for 2013 overall means something has to go. Planetary science seems hardest hit, with the especial blow for European planetary scientists of NASA pulling out of ExoMars, the ESA-led mission to look for signs of life on Mars. Images from the High Resolution Imaging Science Experiment have shown boulders displaced by seismic activity on Mars in the past few million years, and possibly much more recently than that. The bigger the supermassive black hole at the centre of a galaxy, the faster the stars in the galactic bulge rotate. Why this should be so has been something of a puzzle, but now a mechanism that is both powerful and common enough to do the job has been identified.

  15. Prevalence of raised body mass indices and the association with ...

    African Journals Online (AJOL)

    2013-06-11

    Jun 11, 2013 ... prevalence rate from age < 20 to the age group 50-59 year-olds. High BP prevalence rates remained high when overweight and hyperglycaemia prevalence rates decreased from the age of 60. Prevalence rate relationships between age, obesity, total high BP and hyperglycaemia for females are indicated ...

  16. Prevalence and factors associated with smoking intentions among non-smoking and smoking adolescents in Kota Tinggi, Johor, Malaysia.

    Science.gov (United States)

    Hock, Lim Kuang; Ghazali, Sumarni Mohamad; Cheong, Kee Chee; Kuay, Lim Kuang; Li, Lim Hui; Huey, Teh Chien; Ying, Chan Ying; Yen, Yeo Lay; Ching, Fiona Goh Swee; Yi, Khoo Yi; Lin, Chong Zhuo; Ibrahim, Normala; Mustafa, Amal Nasir

    2014-01-01

    Intention to smoke is a valid and reliable factor for predicting future smoking habits among adolescents. This factor, however, has received inadequate attention in Malaysia. The present paper elaborates the prevalence and factors associated with intent to initiate or to cease smoking, among adolescent nonsmokers and smokers in Kota Tinggi, Johor, Malaysia. A total of 2,300 secondary school students aged 13-16 years were selected through a two-stage stratified sampling method. A set of standardized questionnaires was used to assess the smoking behavior among adolescents and the inter-personal and intra-personal factors associated with smoking intention (intention to initiate smoking or to cease smoking). Multivariable logistic regression was used to identify factors related to smoking intention. The prevalence of intention to smoke in the future or to cease smoking among non- smoking adolescents and current smokers were 10.7% and 61.7% respectively. Having friends who smoke, social influence, and poor knowledge about the ill effects on health due to smoking showed significant relationships with intention to smoke in the future among non-smokers. Conversely, perceived lower prevalence of smoking among peers, weak contributory social influence, and greater awareness of the ill effects of smoking are factors associated with the intention to cease smoking sometime in the future. The study found that prevalence of intention to initiate smoking is low among non-smokers while the majority of current smokers intended to cease smoking in the future. Existing anti-smoking programmes that integrate the factors that have been identified in the current study should be put in motion to reduce the prevalence of intention to initiate smoking and increase the intention to cease smoking among adolescents.

  17. Prevalence and genetic basis of tooth agenesis

    Directory of Open Access Journals (Sweden)

    Takehiko Shimizu

    2009-05-01

    Full Text Available Tooth agenesis or hypodontia is one of the most common anomalies of the human dentition, characterized by the developmental absence of one or more teeth. Many studies have reported that the prevalence of congenital absence of permanent teeth varies from 3% to 11% among European and Asian populations. Recent advances in the fields of molecular biology and human genetics have improved our understanding of the cause of tooth agenesis. In this review, we assess the previous literature on prevalence of tooth agenesis comparing the Japanese with other racial populations, and describe the recent genetic studies associated with hypodontia in human and mouse models.

  18. Prevalence of health risk factors among fishermen

    DEFF Research Database (Denmark)

    Frantzeskou, Elpida; Jensen, Olaf; Linos, Athena

    2014-01-01

    AND fisherman OR fishing and only those with precise prevalence estimation were included. Results One Turkish, Scottish, Spanish, Greek and a Danish study were found. The prevalence rate for current smoking varied from 40 % - 82 % in the countries. Daily alcohol use also varied with 80%, 78% and 68 % among...... and accompanied by moderate–high alcohol consumption. On many vessels, food was limited to coffee, sandwiches and occasionally fruit on board. 66% of the Greek fishing workers did not perform any kind of exercise outside work. Obesity (Body mass index > 30.0) was found for 33 % of the Greek fishermen...

  19. Bochdalek hernia: prevalence and CT characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Gale, M.E.

    1985-08-01

    The chest and abdominal computed tomography (CT) scans of 940 patients were reviewed to determine the prevalence of Bochdalek hernias and to evaluate the widely held concept that left-sided hernias occur more than nine times as often as right-sided hernias. Sixty Bochdalek hernias were identified in 52 patients, a prevalence of 6%, which is more than 100 times more frequent than previously reported. Left-sided hernias were found approximately twice as often as right-sided hernias. The Bochdalek hernia is a much more common congenital anomaly in the asymptomatic adult than previously thought and frequently can be identified on routine chest and abdominal CT images.

  20. Prevalent mutations in fatty acid oxidation disorders

    DEFF Research Database (Denmark)

    Gregersen, N; Andresen, B S; Bross, P

    2000-01-01

    : the medium-chain acyl-CoA dehydrogenase (MCAD) gene; the short-chain acyl-CoA dehydrogenase (SCAD) gene; the long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) gene and the carnitine-palmitoyl-CoA transferase II (CPT II) gene. In MCAD deficiency the analysis confirms the conventional wisdom that individuals...... carrying the prevalent 985A > G mutation are at risk of developing life-threatening attacks. In SCAD/ethylmalonic aciduria, on the other hand, the presence of the prevalent susceptibility variations, 625A and 511T, in the SCAD gene seems to require additional genetic and cellular factors to be present...

  1. The prevalence of congenital anomalies in Europe

    DEFF Research Database (Denmark)

    Dolk, Helen; Loane, Maria; Garne, Ester

    2010-01-01

    EUROCAT (European Surveillance of Congenital Anomalies) is the network of population-based registers of congenital anomaly in Europe, with a common protocol and data quality review, covering 1.5 million annual births in 22 countries. EUROCAT recorded a total prevalence of major congenital anomalies...... anomalies overwhelmingly concern children surviving the early neonatal period, who have important medical, social or educational needs. The prevalence of chromosomal anomalies was 3.6 per 1,000 births, contributing 28% of stillbirths/fetal deaths from 20 weeks gestation with congenital anomaly, and 48...

  2. Promoting Policy, Systems, and Environment Change to Prevent Chronic Disease: Lessons Learned From the King County Communities Putting Prevention to Work Initiative.

    Science.gov (United States)

    Cheadle, Allen; Cromp, DeAnn; Krieger, James W; Chan, Nadine; McNees, Molly; Ross-Viles, Sarah; Kellogg, Ryan; Rahimian, Afsaneh; MacDougall, Erin

    2016-01-01

    Initiatives that convene community stakeholders to implement policy, systems, environment, and infrastructure (PSEI) change have become a standard approach for promoting community health. To assess the PSEI changes brought about by the King County, Washington, Communities Putting Prevention to Work initiative and describe how initiative structures and processes contributed to making changes. The impact evaluation used a logic model design, linking PSEI changes to longer-term behavioral impacts in healthy eating active living and tobacco use and exposure. Qualitative methods, including stakeholder interviews and surveys, were used to identify initiative success factors. Communities Putting Prevention to Work activities occurred throughout King County, with a focus on 7 low-income communities in South Seattle/King County. The focus communities had a combined population of 652 000, or 35% of the county total, with lower incomes and higher rates of physical inactivity, tobacco use, poor diet, and chronic disease. Twenty-four PSEI strategies were pursued by organizations in sectors including schools, local governments, and community organizations, supported by the public health department. There were 17 healthy eating active living strategies (eg, enhancements to school menus, city planning policies) and 7 tobacco strategies (eg, smoke-free policies in schools, housing, and hospitals). PSEI changes made and numbers of residents reached. Twenty-two of the 24 strategies achieved significant progress toward implementing PSEI changes. The most common success factor was a "dyad" consisting of a dedicated technical assistance provider-either an outside consultant or public health department staff-working closely with a champion from the participating organizations to bring about PSEI changes. An initiative structure that creates and supports external consultant/internal organizational champion dyads in key community sectors offers a promising approach that may be adopted by

  3. Relationship between blood group, packed cell volume, knowledge and practices of adults to malaria prevalence in Lagos Island, Nigeria

    Directory of Open Access Journals (Sweden)

    Bamidele Akinsanya

    2016-10-01

    Full Text Available Objective: To determine malaria prevalence, knowledge, attitude and practices at residents of Lagos Island Local Government. Methods: Two hundred blood samples were collected from adults attending the General Hospital, Marina while 100 questionnaires were administered to individuals still in the same hospital. Majority of the respondents were between the ages of 18 and 30 years (44%, while the age group 60 and above had the lowest population (9%. Results: More than half of the respondents (68% were employed and engaged in different occupations such as entrepreneur (32%, students (31%, trader (24%, and civil servant (10%. Stratification of the respondents by income revealed that 71% earned above the minimum wage, while 29% earned below. The prevalence of malaria by microscopy method was 10.5%. Malaria parasite had significant effect on the packed cell volume of infected individuals (P < 0.05. Preventive measures employed by the respondents were majorly insecticide (72.2%, while some others (5.6% used mosquito net. Majority of the respondents (98% believed that malaria was caused by mosquito. Conclusions: Therefore, it is appropriate to put in place preventive measures against malaria to avoid high prevalence of the number one killer in tropical Africa.

  4. Prevalence and risk factors of anaemia among children aged between 6 months and 14 years in Kenya.

    Directory of Open Access Journals (Sweden)

    Oscar Ngesa

    Full Text Available Anaemia is one of the significant public health problems among children in the world. Understanding risk factors of anaemia provides more insight to the nature and types of policies that can be put up to fight anaemia. We estimated the prevalence and risk factors of anaemia in a population-based, cross-sectional survey.Blood samples from 11,711 children aged between 6 months and 14 years were collected using a single-use, spring-loaded, sterile lancet to make a finger prick. Anaemia was measured based on haemoglobin concentration level. The generalized linear model framework was used to analyse the data, in which the response variable was either a child was anemic or not anemic.The overall prevalence of anaemia among the children in Kenya was estimated to be 28.8%. Across each band of age within which the definition of anaemia remained constant (0–4, 5–11, and 12–14 years old, the prevalence of anaemia declined with each year of age. [corrected]. The risk of anaemia was significantly higher in male than female children. Mothers with secondary and above education had a protective effect on the risk of anaemia on their children. Malaria diagnosis status of a child was positively associated with risk anaemia.Controlling co-morbidity of malaria and improving maternal knowledge are potential options for reducing the burden of anaemia.

  5. Prevalence and risk factors of anaemia among children aged between 6 months and 14 years in Kenya.

    Science.gov (United States)

    Ngesa, Oscar; Mwambi, Henry

    2014-01-01

    Anaemia is one of the significant public health problems among children in the world. Understanding risk factors of anaemia provides more insight to the nature and types of policies that can be put up to fight anaemia. We estimated the prevalence and risk factors of anaemia in a population-based, cross-sectional survey. Blood samples from 11,711 children aged between 6 months and 14 years were collected using a single-use, spring-loaded, sterile lancet to make a finger prick. Anaemia was measured based on haemoglobin concentration level. The generalized linear model framework was used to analyse the data, in which the response variable was either a child was anemic or not anemic. The overall prevalence of anaemia among the children in Kenya was estimated to be 28.8%. Across each band of age within which the definition of anaemia remained constant (0–4, 5–11, and 12–14 years old), the prevalence of anaemia declined with each year of age. [corrected]. The risk of anaemia was significantly higher in male than female children. Mothers with secondary and above education had a protective effect on the risk of anaemia on their children. Malaria diagnosis status of a child was positively associated with risk anaemia. Controlling co-morbidity of malaria and improving maternal knowledge are potential options for reducing the burden of anaemia.

  6. Estimation of HPV prevalence in young women in Scotland; monitoring of future vaccine impact

    Science.gov (United States)

    2013-01-01

    Background Estimation of pre-immunisation prevalence of HPV and distribution of HPV types is fundamental to understanding the subsequent impact of HPV vaccination. We describe the type specific prevalence of HPV in females aged 20–21 in Scotland who attended or defaulted from cervical screening using three specimen types; from attenders liquid based cytology and from defaulters urine or self-taken swabs. Methods Residual liquid based cytology samples (n = 2148), collected from women aged 20–21 attending for their first smear were genotyped for HPV. A sample (n = 709) from women who had defaulted from screening was also made available for HPV testing through the use of postal testing kits (either urine samples (n = 378) or self-taken swabs (n = 331)). Estimates of prevalence weighted by deprivation, and for the postal testing kit, also by reminder status and specimen type were calculated for each HPV type. The distribution of HPV types were compared between specimen types and the occurrence of multiple high-risk infections examined. The influence of demographic factors on high-risk HPV positivity and multiple infections was examined via logistic regression. Results The prevalence of any HPV in young women aged 20–21 was 32.2% for urine, 39.5% for self-taken swab, and 49.4% for LBC specimens. Infection with vaccine specific types (HPV 16, 18) or those associated with cross-protection (HPV 31, 33, 45, 51) was common. Individuals were more likely to test positive for high-risk HPV if they resided in an area of high deprivation or in a rural area. The overall distribution of HPV types did not vary between defaulters and attenders. Multiple infections occurred in 48.1% of high-risk HPV positive individuals. Excluding vaccine types the most common pairing was HPV 56 and 66. Conclusions Understanding of the pre-immunisation prevalence of HPV in young women puts Scotland in a prime position to assess the early effect of vaccination as the first highly

  7. 4 Prevalence of Snail.cdr

    African Journals Online (AJOL)

    Administrator

    to infection (Webbe, 1981) and about 131 million infected in Sub-Saharan Africa alone. The disease is endemic in Ghana and its public health importance was reported by. McCullough (1954), who noted then that approximately 20% of the total population of. Prevalence of Snail Vectors of Schistosomiasis in the Kpong.

  8. Prevalence of Depression in Postmenopausal Women

    OpenAIRE

    Afshari; Manochehri; Tadayon; Kianfar; Haghighizade

    2015-01-01

    Background Every woman during different stages of her growth faces various crises, and one of these crises, menopause, may create different problems. In modern societies, psychological disorders and particularly depression is one of the problems of menopausal women. Objectives This study aimed to evaluate the prevalence of depression in postmenopausal women referred to selected health centers of Ahvaz in 2014. ...

  9. SHORT COMMUNICATION Prevalence of hypertension and ...

    African Journals Online (AJOL)

    2. SHORT COMMUNICATION. Prevalence of hypertension and variation of blood pressure with age among adolescents in ... The mean diastolic blood pressure increased by 1.55 mmHg and 1.42mmHg per year, respectively. The age ... and increased expectation of life, non-communicable life style related diseases are.

  10. Relative prevalences of Ascaris lumbricoides and Entamoeba ...

    African Journals Online (AJOL)

    A study was conducted among school children in Yauri Emirate of Nigeria to determine the relative prevalences of Ascaris lumbricoides and Entamoeba histolytica infections. Between May and September 2005 a total of 327 faecal samples from children were collected and examined using formal-ether concentration ...

  11. SACHET WATER: PREVALENCE OF USE, PERCEPTION AND ...

    African Journals Online (AJOL)

    Zamzar

    ABSTRACT. Background: Sachet water is a phenomenon that has gained widespread use as an alternative to the insufficient provision of potable water. It is an alternative that is readily available, affordable but not without concerns about its purity. The objective of this study is to determine the prevalence of use, perception ...

  12. Prevalence, histopathological findings and aerobic bacteria flora ...

    African Journals Online (AJOL)

    Aerobic bacteria isolated from the lungs with pneumopathies were E. coli, Klebsiella pneumoniae, Mannheimia haemolytica, Streptococcus pyogenes, Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris and Pasteurella multocida. E. coli with a prevalence rate of 73.5% was the most predominant isolate. There was ...

  13. Anaemia prevalence and factors associated with haemoglobin ...

    African Journals Online (AJOL)

    Information on social-clinical characteristics, cancer type and associated factors as well as haemoglobin level before and after radiation were obtained. The prevalence of anaemia was determined as a proportion and linear regression was used to determine factors associated with haemoglobin change. Results: A total of ...

  14. Prevalence of nutrient deficiencies in bariatric patients.

    Science.gov (United States)

    Toh, Seok Yee; Zarshenas, Nazy; Jorgensen, John

    2009-01-01

    The aims of this study were to determine the prevalence of nutrient deficiencies in patients who present for bariatric surgery, assess nutritional status after surgery, and compare these with preoperative levels. A retrospective study was conducted to identify preoperative and 1-year postoperative nutrition deficiencies in patients undergoing bariatric surgery. The screening included serum ferritin, vitamin D, vitamin B(12), homocysteine, folate, red blood cell folate, and hemoglobin. Results were available for 232 patients preoperatively and 149 patients postoperatively. Two-tailed chi(2) tests and paired-sample t tests were used. Preoperatively, vitamin D deficiency was noted at 57%. The prevalence of abnormalities 1 year after roux-en-Y gastric bypass was higher compared with preoperative levels (P surgery, anemia was detected in 17%, elevated homocysteine levels (women only) in 29%, low ferritin in 15%, low vitamin B(12) in 11%, and low RBC folate in 12%. Mean hemoglobin, ferritin, and RBC folate levels deteriorated significantly but remained well within normal ranges. The prevalence of vitamin D deficiencies decreased, but not significantly. In sleeve gastrectomy patients, mean ferritin levels decreased (P deficiency. Vitamin D deficiency is common among morbidly obese patients seeking bariatric surgery. Because the prevalence of micronutrient deficiencies persists or worsens postoperatively, routine nutrition screening, recommendation of appropriate supplements, and monitoring adherence are imperative in this population.

  15. Prevalence of nutrition associated ponderal outcomes among ...

    African Journals Online (AJOL)

    ... and 7.6%, respectively, in the urban subjects and 1.5%, 2.3% and 20.3%, respectively, in the rural subjects. Conclusion: The prevalence of underweight among rural school children and adolescents is high, thus a need for nutritional intervention. Keywords: Ebonyi state, nutritional, obesity, overweight, South‑East Nigeria, ...

  16. High prevalence of osteoporosis in Saudi men

    International Nuclear Information System (INIS)

    El-Desouki, Mahmoud I.; Sulimani, Riyadh A.

    2007-01-01

    Objective was to determine the prevalence of osteoporosis in healthy Saudi men. We randomly recruited 429 Saudi men from the community. The recruited Saudi men were subjected to an interview to reveal their lifestyle parameters, calcium intake and level of activity. Bone densitometry was assessed at lumbar spine (L-4) and the femoral neck. The dual x-ray absorptiometry (DXA) scan was carried out in the Nuclear Medicine at King Khalid University Hospital, Riyadh, Saudi Arabia from September 2002 to December 2004. The World Health Organization definition of low bone mineral density was used. Poor oral calcium intake and low level of daily activity were noted. The overall prevalence of osteopenia for the lumbar spine in the whole group was 35.7% while osteoporosis was present in 21.4% of the subjects. In the femoral neck, osteopenia was noted in 38% and osteoporosis in 11.4%. When either lumbar spine or femoral neck osteoporosis is used for diagnosis, the prevalence of osteoporosis rises to 23.5%. Within the whole group, osteopenia and osteoporosis were more common in individuals above the age of 50 than those below 50 years old. Low bone mineral density occurs with high frequency in Saudi men. Lumbar spine appears to be affected to a higher degree. The reason for the high prevalence of osteoporosis in Saudi men is unclear. Possible underlying causes include nutritional, life style and genetic factors. (author)

  17. The Prevalence of Inflammatory and Developmental Odontogenic ...

    African Journals Online (AJOL)

    Objective: The aim of this study was to determine the prevalence of odontogenic jaw cysts in a Libyan population and to compare the data with previously published ... cysts in different ethno-geographic backgrounds is essential for the early diagnosis and management of these benign yet potentially destructive lesions.

  18. Prevalence of stuttering in African American preschoolers.

    Science.gov (United States)

    Proctor, Adele; Yairi, Ehud; Duff, Melissa C; Zhang, Jie

    2008-12-01

    In this study, the authors sought to determine the prevalence of stuttering in African American (AA) 2- to 5-year-olds as compared with same-age European Americans (EAs). A total of 3,164 children participated: 2,223 AAs and 941 EAs. Data were collected using a 3-pronged approach that included investigators' individual interactions with each child, teacher identification, and parent identification of stuttering. No statistically significant difference for stuttering was found between AA and EA children. Using the investigator and teacher method of identification, the prevalence of stuttering was 2.52% for the entire sample. For both racial groups, boys exhibited a higher prevalence of stuttering than girls. Of the 3 predictors (age, race, sex) of stuttering, only sex was a significant predictor. AA 2- to 5-year-olds are not overrepresented in the stuttering population for this age group. When data are combined for both racial groups, the prevalence of stuttering is 2.52%. More boys than girls stuttered in this sample of preschoolers.

  19. Prevalence of Physical, Verbal and Nonverbal

    African Journals Online (AJOL)

    GB

    90.4% and 80.0%, respectively, while the prevalence rate of psychological distress among students who ... A survey study in a school in America revealed that more than 80%. 1Department of Psychology, College of Education and Behavioral Sciences, Jimma University, ... 52(13.5%) from Social Science and Law, 38.

  20. Factors Associated with Prevalent Tuberculosis Among Patients ...

    African Journals Online (AJOL)

    Abstract. Background: Tuberculosis (TB) causes significant morbidity/mortality among human immunodeficiency virus‑infected individuals in Africa. Reducing TB burden in the era of highly active antiretroviral therapy (HAART) is a public health priority. Aim: We determined the factors associated with prevalent TB among ...

  1. Neonatal hypoglycaemia: prevalence and clinical manifestations in ...

    African Journals Online (AJOL)

    Background: Neonatal hypoglycaemia is associated with significant long term neuro-developmental sequelae. The signs and symptoms are often non-specific. Some are completely asymptomatic. Many cases therefore remain undiagnosed. This study was therefore designed to determine the prevalence, obstetric and ...

  2. Antisocial personalities: Measuring prevalence among offenders in ...

    African Journals Online (AJOL)

    The identification of offenders who meet the criteria for psychopathy, antisocial personality disorder or dissocial personality disorder could be of significant value to help address the violent crime crisis in South Africa. A sample of 500 male maximum security offenders was selected to determine the prevalence of these ...

  3. immunological arthritis Prevalence of biochemical and abnormalities ...

    African Journals Online (AJOL)

    1991-02-02

    Feb 2, 1991 ... Tile prevalence of biochemical and immunological abnormali- ties was studied in a group of 256 patients with rheumatoid arthritis (104 coloureds, 100 whites and 52 blacks). The most common biochemical abnormalities detected were a reduction in the serum creatinine value (43,4%), raised globulins (39 ...

  4. Prevalence, types and factors associated with echocardiographic ...

    African Journals Online (AJOL)

    Non invasive identification of cardiac abnormalities, such as Left Ventricular Hypertrophy (LVH), diastolic and systolic dysfunction, is not part of diabetes complications surveillance programs in Uganda and there is limited data on this problem. This study sought to determine the prevalence, types and factors associated with ...

  5. Risk assessment: Prevalent occupational hazards in Nigerian ...

    African Journals Online (AJOL)

    Background: In terms of human suffering and related economic costs, the magnitude of global impact of occupational accidents and diseases, as well as major industrial disasters, has been a long-standing source of concern at the international, national, and workplace level. Objective: To define the prevalent hazards in the ...

  6. Prevalence of Psychiatric Disorders in Preschoolers

    Science.gov (United States)

    Wichstrom, Lars; Berg-Nielsen, Turid Suzanne; Angold, Adrian; Egger, Helen Link; Solheim, Elisabet; Sveen, Trude Hamre

    2012-01-01

    Background: Many disorders in childhood and adolescence were already present in the preschool years. However, there is little empirical research on the prevalence of psychiatric disorders in young children. A true community study using structured diagnostic tools has yet to be published. Methods: All children born in 2003 or 2004 in the city of…

  7. Prevalence, types and psychopathologic consequences of female ...

    African Journals Online (AJOL)

    Using GHQ-12, Psychopathologic consequence of FGC was assessed among those who underwent FGC. Results: The prevalence of FGC among respondents in this study was 22.5%. Type 2a (removal of labia minora only) was the predominant type of FGC among respondents accounting for 64.6%; this was followed by ...

  8. Prevalence of Helicobacter Pylori Infection Among Patients ...

    African Journals Online (AJOL)

    was seen. Conclusion: The prevalence of H. pylori infection is significantly high in rural and suburban population of Ernakulam district, Kerala. Early detection and prompt treatment are essential for prevention of serious complications. Keywords: Gastrointestinal complications, Helicobacter pylori infection, Histopathological ...

  9. Upper gastrointestinal endoscopic findings and prevalence of ...

    African Journals Online (AJOL)

    Upper gastrointestinal endoscopic findings and prevalence of Helicobacter pylori infection among adult patients with dyspepsia in northern Tanzania. ... Endoscopy (EGD) for initial work up. Study on antimicrobial susceptibility pattern of H. pylori is recommended to guide choices for evidence based treatment option.

  10. Prevalence of hepatitis B virus among immunocompromised ...

    African Journals Online (AJOL)

    Hepatitis B is an infectious inflammatory illness of the liver caused by the hepatitis B virus (HBV) which is transmitted to a large population through blood transfusion or by exposure to other body fluids. HBV is a member of the family Hepadnaviridae and also a DNA virus. In this study, the prevalence of hepatitis B infection ...

  11. Prevalence of hypocalcaemia and maternal complications among ...

    African Journals Online (AJOL)

    Background: Plasma Calcium level is not a routine laboratory test conducted during pregnancy. The role of calcium supplementation to prevent maternal complications of pregnancy such as pre-eclampsia and pregnancy induced leg cramps is conflicting. Objective: To determine the prevalence of hypocalcaemia and ...

  12. Prevalence of Human Immunodeficiency Virus Transmission among ...

    African Journals Online (AJOL)

    for transfusion at the UNTH blood bank alone where a higher standard of ensuring safe blood transfusions is expected. Sexually active adults were included in the Lagos study and this may mean an additional risk factor for HIV transmission through sex. In contrast, the 1.6% sero-prevalence among the control group in this ...

  13. Prevalence and Antifungal Susceptibility of Candida Species ...

    African Journals Online (AJOL)

    Candidal vulvovaginitis causes extreme discomfort and affects the well being of women. The aim of this study was to determine the prevalence of Candida infections among women attending gynaecological clinic at the Komfo Anokye Teaching Hospital (KATH) in Kumasi and the antifungal susceptibility patterns of the ...

  14. Original Paper Prevalence of Arcobacter, Escherichia coli ...

    African Journals Online (AJOL)

    2011-04-12

    Apr 12, 2011 ... Prevalence of Arcobacter, Escherichia coli, Staphylococcus aureus and ... species by selective cultural procedures and for Escherichia coli, Salmonella species and Staphylococcus aureus enriched ... Point System monitoring of critical contamination points used in meat production to ensure food safety in.

  15. Prevalence and associated characteristics of cytomegalovirus (CMV ...

    African Journals Online (AJOL)

    Background: The screening for cytomegalovirus (CMV) specific antibodies is not routine in our setting, thus the transfusion of blood portends high risk for susceptible individuals. Objective: To determine the prevalence of IgG and IgM specific antibodies and associated characteristics in blood donors seen at a referral ...

  16. Prevalence of accommodative insufficiency and accommodative ...

    African Journals Online (AJOL)

    This study sought to determine the prevalence of accommodative dysfunctions among Junior High School students in the Sunyani Municipality in the Brong Ahafo region of Ghana. All the 204 students who were present in the randomly selected Junior High School on the day of the data collection participated in the study.

  17. Prevalence of musculoskeletal injuries among adolescent squash ...

    African Journals Online (AJOL)

    Objective. To determine the prevalence of musculoskeletal injuries among adolescent squash players in the Western Cape. Design. A retrospective descriptive survey was conducted during the first week of May 2006. Three schools were randomly selected from a list of the top 10 schools in the. Western Cape high school ...

  18. Prevalence of Cryptosporidium species and Giardia intestinalis ...

    African Journals Online (AJOL)

    Cryptosporidium species and Giardia intestinalis cause diarrheal infections in humans and other vertebrate animals globally and are considered to be of great public health importance. The study was conducted to determine the prevalence Cryptosporidium species and G. intestinalis infections among patients attending ...

  19. Prevalence of Campylobacter foetus and Trichomonas foetus ...

    African Journals Online (AJOL)

    Administrator

    2011-09-05

    Sep 5, 2011 ... 2Zoonotic Diseases Section, Agricultural Research Council-Onderstepoort Veterinary Institute (ARC-OVI), 100 Old. Soutpan Road ... abortion. The aim of this retrospective study was to estimate the prevalence of C. foetus and T. foetus .... These include Brucella spp, Listeria monocytogenes,. Leptospira spp.

  20. Prevalence of biochemical and immunological abnormalities in ...

    African Journals Online (AJOL)

    Tile prevalence of biochemical and immunological abnormalities was studied in a group of 256 patients with rheumatoid arthritis (104 coloureds, 100 whites and 52 blacks). The most common biochemical abnormalities detected were a reduction in the serum creatinine value (43,4%), raised globulins (39,7%), raised serum ...

  1. Prevalence factors associated with Hypertension in Rukungiri ...

    African Journals Online (AJOL)

    Background: Hypertension is a growing public health problem in Uganda and Africa as a whole. We conducted a study to determine the prevalence and identify factors associated withy hypertension among residents of the rural district of Rukungiri, Uganda. Methods: A community-based cross-sectional study design was ...

  2. Prevalence of Autism Spectrum Disorders: data review

    Directory of Open Access Journals (Sweden)

    Francisco ALCANTUD MARÍN

    2017-10-01

    Full Text Available Published data on the prevalence of autism spectrum disorders point to a significant increase in this indicator. This increase is being studied in numerous publications of analysis, meta-analysis and systematic reviews. The prevalence indicates the proportion of people who suffer at a given time or are diagnosed with a disease. The consequences of the increasing prevalence are relevant from the point of health, social and educational, but especially relevant when as is the case, the cause of the disorder is unknown. It is in this sense that the prevalence study gains importance in order to delimit various circumstances that may give clues to the possible cause or causes that generate disorder. This article reviews studies, summarizes the last data, and reflects on them and possible causes that justify the increased reporting. It looks like these epidemiological indicators can or are influenced by possible methodological flaws behind, which can explain the variations between studies and others. It concludes by stating the need population studies and monitoring that allows us to know the reality of the evolution of these disorders in order to provide reliable information to those responsible for the institutions involved in the detection and treatment of ASD.

  3. Prevalence and Correlates of Psychiatric Disorders among ...

    African Journals Online (AJOL)

    This study aims to determine the pattern, prevalence and correlates of psychiatric disorders among the residents of a juvenile justice facility in Nigeria and to speculate appropriate policy responses. METHODS: Using a cross-sectional comparative study design, 60 consecutive residents of the Ibadan juvenile Remand home ...

  4. Prevalence and characterization of verotocytoxin producing ...

    African Journals Online (AJOL)

    Escherichia coli O157:H7 is an important agent of haemorrhagic colitis and haemolytic uraemic syndrome in children less than five years old and elderly people. The objective of this study was to investigate the prevalence of verotocytoxin producing E. coli 0157 (VTEC O157) among human patients with diarrhoea in ...

  5. Prevalence and temporal distribution of Schistosoma haematobium ...

    African Journals Online (AJOL)

    Jane

    2010-10-18

    Oct 18, 2010 ... (2003 and 2004). Occurrence of S. haematobium among hospital patients, university students and primary school children. The analysis of the urine samples collected from the hospitals indicated even higher prevalence of schisto- somiasis among out-patients visiting the hospitals for urinary tract infections.

  6. SEROEPIDEMIOLOGICAL STUDY OF PREVALENCE OF MALARIA ...

    African Journals Online (AJOL)

    The roles of causative factors responsible for prevalence of malaria in the village of Solana, India, were studied. Mosquitoes and larvae density in and around the area were measured by process of random sampling and counting their numbers under microscopy. Malaria in population of the village was diagnosed by ...

  7. The prevalence of electroencephalographic abnormalities and ...

    African Journals Online (AJOL)

    Adele

    2004-05-20

    May 20, 2004 ... South African studies. There is little South African data examining either prevalence or usefulness of EEG abnormalities among adult psychiatric patients. Some work has been done in adolescents. Szabo1 reviewed all admissions to the adolescent inpatient unit at Tara. Hospital between 1990 and 1995.

  8. TABLE PREVALENCE OF GIT NEMATODES IN CATTLE

    African Journals Online (AJOL)

    User

    A study was carried out on the prevalence of gastrointestinal (GI) nematodes infection in naturally infected cattle in Ogbomoso area of Oyo State using standard parasitological techniques. The results indicated that out of the 1000 cattle examined, 30(3%) were infected and parasites identified were Haemonchus contortus.

  9. Prevalence, knowledge attitude and practices associated with ...

    African Journals Online (AJOL)

    In this survey, the Knowledge, Attitude and Practice (KAP) and prevalence of onchocerciasis were evaluated. For the KAP aspect of this survey, Interviewers administered questionnaire was used as instrument for collecting information from Respondents who participated in the skin snipping exercise. Skin snips were ...

  10. Prevalence and Susceptibility of extended spectrum beta ...

    African Journals Online (AJOL)

    Extended spectrum beta – lactamases (ESBLs) are on the rise in hospital settings across the globe. The presence of ESBLs significantly affects the outcome of an infection and poses a challenge to the management of infection worldwide. Therefore, the aim of the present study is to determine the prevalence and ...

  11. Prevalence, aetiology and antibiotic sensitivity profile of ...

    African Journals Online (AJOL)

    Escherichia coli were the common organism isolated at 38.8%. The majority of the organisms were sensitive to imipenem and gentamycin. Conclusion: There is a high prevalence of ASB among pregnant women included in the study from the Nairobi county clinics. Therefore, routine ASB screening of pregnant women is ...

  12. Prevalence of parasitic gastrointestinal nematodes of small ...

    African Journals Online (AJOL)

    A cross-sectional study was conducted from December, 2014 to May, 2015 on 914 animals (345 sheep and 569 goats) at Jalingo abattoir, Taraba State, Nigeria based on faecal examination. The objective of the study was to determine the prevalence rate of parasitic gastrointestinal nematodes in slaughtered small ...

  13. Bullying in Academe: Prevalent, Significant, and Incessant

    Science.gov (United States)

    Cassell, Macgorine A.

    2011-01-01

    This paper examines the top-down perspective of bullying and mobbing of professors by analyzing why it is prevalent, significant, and incessant and then proposes a framework to produce a caring, respectful, and safe environment for professors to engage in their teaching, scholarship, and service. The author suggests that the failure of…

  14. Prevalence of keratoconus in an adolescent population

    Directory of Open Access Journals (Sweden)

    Jorge E. Valdez-García

    2014-07-01

    Conclusion: Through this study, we found that our statistics matched those of internationally published reports concerning the early age of onset of the disease and its corresponding bilateralism. However, contrary to the international reports, it was evident that this condition was more prevalent among the females in our study sample, and no other associated pathologies were found.

  15. Cofactors Influencing Prevalence and Intensity of Schistosoma ...

    African Journals Online (AJOL)

    Urine samples were collected from 657 individuals and analyzed by centrifugation, and the number of ova was determined by microscopy. ... Cattle rearing (OR=9.01; CI=4.00-20.75; P=0.00) and farming (OR=3.14; CI=1.82-5.43; P=0.00) showed significant association with the prevalence and intensity of the disease.

  16. Prevalence And Factors Associated With Chronic Diabetic ...

    African Journals Online (AJOL)

    Background: A substantial proportion of patients with diabetes develop long-term macrovascular and microvascular complications. Many risk factors have identified for development and progression of these complications. Objectives: The aim of the present study was to determine the prevalence of these complications ...

  17. Prevalence of musculoskeletal injuries among young squash ...

    African Journals Online (AJOL)

    The aim of the study was to investigate the prevalence of musculoskeletal injuries sustained by young squash players in Malaysia. This study was conducted retrospectively by using. Standardized Nordic Questionnaire (NSQ) during SUKMA 2016 at Kuching, Sarawak, Malaysia. The questionnaires were distributed to the ...

  18. Prevalence and determinants of cigarette smoking among ...

    African Journals Online (AJOL)

    Tobacco smoking is a major risk factor for non-communicable diseases such as ischaemic heart disease, stroke, chronic obstructive airways disease and several cancers. There is little data about the prevalence and determinants of smoking among adolescents in southern Africa. This study aimed to determine the ...

  19. PREVALENCE OF BIRD LOUSE, MENACANTHUS CORNUTUS ...

    African Journals Online (AJOL)

    ADMIN

    2014-06-01

    Jun 1, 2014 ... Keywords: Bird Louse, Kano Sub-urb areas, Menacanthus cornutus, Poultry, Prevalence ... including retarded growth, low egg production and ..... Bush, S. E. and Clayton, D. H.. (2005). Correlated evolution of host and parasite body size: Tests of Harrison's rule using birds and lice. Evolution, 59: 1744-.

  20. Prevalence of behavioral changes in senile dogs

    Directory of Open Access Journals (Sweden)

    Denis Jeronimo Svicero

    Full Text Available ABSTRACT: Owing to improvements in animal welfare, such as in nutrition, preventive medicine, and diagnostic tools, older dogs have become increasingly more prevalent than before. Unfortunately, there is an increasing number of dogs presenting behavioral changes correlated with this growth in the geriatric population. However, many of these owners consider these signs as normal for old age. This study aimed to determine the prevalence of clinical signs related with behavioral changes in the canine geriatric population admitted to the Veterinary Hospital of the Veterinary Medicine and Animal Science College of Universidade Estadual Paulista. The owners of 800 old dogs completed a questionnaire about disorientation, changes in social interaction, loss of training (house soiling, changes in the wake-sleep cycle, physical activity, memory, learning, consciousness, and perception. The results showed that the prevalence of behavioral changes in the canine geriatric population was 90.7% of dogs that presented at least one of these behavioral changes, and 22.3% with at least six changes, and with changes in physical activity (58.5% and loss of acquired training (30.2% being the highest percentage groups that were reported by the owners. We concluded that the prevalence of behavioral changes related with aging in the canine geriatric population was high, and that it was important to include questions about behavioral changes during regular veterinary clinical appointments to identify these clinical signs earlier and investigate the possible causes of the cognitive impairment, including neurological diseases, such as Canine Cognitive Dysfunction Syndrome.

  1. Prevalence and antibiotic susceptibility pattern of methicillin ...

    African Journals Online (AJOL)

    Methicillin resistant Staphylococcus aureus (MRSA) is a multidrug resistant bacterium that threatens the continued effectiveness of antibiotics worldwide. The objective of this study was to investigate the prevalence of MRSA and its antibiotic susceptibility pattern in patients with burns and bedsore. This was a cross- sectional ...

  2. Prevalence of methicillin resistant Staphylococcus aureus and ...

    African Journals Online (AJOL)

    Staphylococcus aureus is the leading overall cause otf nosocomial infections with increasing resistance to β lactam antibiotics. This study was carried out to study the current resistant/susceptibility pattern of S. aureus to β lactam antibiotics and prevalence of Methicillin Resistant S. aureus (MRSA) in the studied population.

  3. Prevalence of obesity, diabetes mellitus, hypertension and ...

    African Journals Online (AJOL)

    Prevalence of ODH increased with age, professional grade, nature of work, gender and reported alcohol use. Smoking 10 or more cigarettes per day increased risk of ... biomedical and behavioral risk factors. A NCD prevention program and close monitoring of disease and risk factors trends are needed in this population.

  4. The prevalence of metabolic syndrome components, individually ...

    African Journals Online (AJOL)

    The prevalence of metabolic syndrome components, individually and in combination, in male patients admitted with acute coronary syndrome, without previous diagnosis of diabetes mellitus. ... They were categorized according to the specific criteria stated in the latest joint statement for the global definition of MS. Results: ...

  5. Prevalence Of Sleep Disturbances Among Primary Informal ...

    African Journals Online (AJOL)

    Conclusion: Caregivers are at almost thrice the risk of sleep disturbances than the noncaregivers (OR = 2.7, CI= 1.26-1.74). Periodic screening of caregivers should be done with specific sleep instruments especially for those of them who operate dangerous machinery and commercial vehicles. Keywords: Prevalence, Sleep ...

  6. Prevalence of Chlamydia trachomatis infections in symptomatic ...

    African Journals Online (AJOL)

    Jane

    2011-07-11

    Jul 11, 2011 ... Chlamydia trachomatis is a ubiquitous human pathogen that is responsible for the most prevalent bacterial sexually transmitted disease worldwide. Studies show that polymerase chain reaction (PCR) is more sensitive than cellular culture for detection of C. trachomatis infections. The aim of this study is to.

  7. Prevalence of anxiety and depressive erectile dysfunction

    African Journals Online (AJOL)

    The primary illness is that of depression, with ED a symptom of the depressive disorder. Prevalence of anxiety and depressive symptoms in men with erectile dysfunction. K Pankhurst, MB ChB. G Joubert, BA, MSc. P J Pretorius, MB ChB, MMed (Psych). Departments of Psychiatry and Biostatistics,. University of the Free State ...

  8. Prevalence and Predictors of Hypertension History among ...

    African Journals Online (AJOL)

    Background: Hypertension is one of the leading causes of mortality and morbidity around the world and has become a public health problem. Meanwhile, information on predictors of hypertension in Ghana seldom focuses on men. This study, therefore, sought to determine the prevalence and predictors of hypertension ...

  9. THE PREVALENCE OF CHILD ABUSE AMONG UNIVERSITY ...

    African Journals Online (AJOL)

    This is an investigation into the prevalence of child psychological, physical, emotional, and ritualistic abuse among a sample of university students. A retrospective self-rating questionnaire was completed by 722 University of the North undergraduate students (South Africa) in a classroom setting. The questionnaire ...

  10. Prevalence of naevi in school children

    OpenAIRE

    Sharma N; Sharma R

    1991-01-01

    The prevalence of naevi in general and pigmented (melanocytic) naevi in particular was studied in school children. Naevi were seen in 73.6% of the examined children, while 73.1% of them had pigmented naevi. The average number of naevi was 5.4 per child with slight male preponderance. There was complete absence of naevi over palms and soles.

  11. Prevalence and susceptibility pattern of methicillinresistant ...

    African Journals Online (AJOL)

    Multi-resistant methicillin-resistant Staphylococcus aureus (MMRSA) has been commonly reported to be one of the commonest causes of nosocomial infections worldwide. Also, recent reports describe methicillin-resistant S. aureus (MRSA) carriage in persons in the community. The study investigated its prevalence in urine ...

  12. Prevalence of Malnutrition and Associated Factors among ...

    African Journals Online (AJOL)

    BACKGROUND: HIV/AIDS predisposes to malnutrition. Malnutrition exacerbates HIV/AIDS progression resulting in increased morbidity and mortality. The magnitude of malnutrition in HIV/AIDS patients has not been well studied in Ethiopian setup. Our objective was to assess the prevalence of malnutrition and associated ...

  13. Prevalence and factors associated with anthropometric failure ...

    African Journals Online (AJOL)

    Background: Under nutrition is a problem of severe magnitude in low income countries like Nigeria. Adolescent school children might also be vulnerable. The dearth of data hinders planning of school health and nutrition programmes for school children. Objective: To determine the prevalence of stunting, thinness; vitamin A ...

  14. Prevalence of sleepwalking in an adult population

    African Journals Online (AJOL)

    2010-01-07

    Jan 7, 2010 ... Prevalence of sleepwalking in an adult population. Celestine Okorome Mume*. Department of Mental Health, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Osun. State, Nigeria. Background: Sleepwalking consists of a series of behavioral activities that occur during sleep. These activities.

  15. Prevalence of Microalbuminuria among secondary school children ...

    African Journals Online (AJOL)

    ... DM and in one subject with sickle cell anemia. Conclusion: The prevalence of microalbuminuria in Nigerian adolescents is high. We recommend routine screening for microalbuminuria in adolescents for early detection and prevention of renal damage. Key words: microalbuminuria, obesity, hypertension, children, Nigeria ...

  16. Depression and anxiety in multisomatoform disorder: Prevalence ...

    African Journals Online (AJOL)

    Objective. Multisomatoform disorder (MSD) is characterised by ≥3 medically inexplicable, troublesome physical symptoms, together with a ≥2-year history of somatisation. The aim of this study was to evaluate the prevalence of depressive and anxiety disorders in a South African sample MSD, and to compare demographic ...

  17. Prevalence of Work Related Musculoskeletal Disorders Among ...

    African Journals Online (AJOL)

    Self‑reporting work related questionnaire on MSDs were distributed, including information on the location of MSD symptoms in the past 12 months and the pain experienced. Results: Musculoskeletal pain was most prevalent among dentists 61% (61/100), followed by surgeons 37% (37/100) and physicians 20% (20/100).

  18. Prevalence And Antimicrobial Susceptibility Pattern Of Methicillin ...

    African Journals Online (AJOL)

    Methicillin resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. We report the prevalence and antibiotic susceptibility pattern of MRSA in Amravati, Maharashtra state (India). A total of 150 healthcare-associated (HA) sources (doctors mobiles phone and wound/pus swabs), and 160 ...

  19. Obsessive compulsive disorder- prevalence in Xhosaspeaking ...

    African Journals Online (AJOL)

    Obsessive compulsive disorder- prevalence in Xhosaspeaking schizophrenia patients. ... No concordance for OCD was noted in the sibship group. Our findings differ from those in other parts of the world, and if replicated, might suggest unique protective environmental or genetic factors for OCD in certain ethnic groups.

  20. prevalence of schistosomiasis among secondary school boarding

    African Journals Online (AJOL)

    emmy

    the study area. Keywords: Prevalence, Schistosomiasis, Boarding students, Potiskum, North-Eastern Nigeria. INTRODUCTION. Schistosomiasis is the most common parasite transmitted through contact with fresh water. It is endemic in more than 70 low income countries where it occurs in rural areas and the fringes of cities.