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  1. Measurement of antral follicle count in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey.

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    Christianson, Mindy S; Shoham, Gon; Tobler, Kyle J; Zhao, Yulian; Cordeiro, Christina N; Leong, Milton; Shoham, Zeev

    2015-10-01

    The purpose of the present study was to identify trends in the therapeutic approaches used to measure antral follicle count (AFC) in patients undergoing in vitro fertilization (IVF) treatment worldwide. A retrospective evaluation utilizing the results of a web-based survey, IVF-Worldwide ( www.IVF-Worldwide.com ), was performed. Responses from 796 centers representing 593,200 cycles were evaluated. The majority of respondents (71.2 %) considered antral follicle count as a mandatory part of their practice with most (69.0 %) measuring AFC in the follicular phase. Most respondents (89.7 %) reported that they would modify the IVF stimulation protocol based on the AFC. There was considerable variation regarding a limit for the number of antral follicles required to initiate an IVF cycle with 46.1 % designating three antral follicles as their limit, 39.9 % selecting either four or five follicles as their limit, and 14.0 % reporting a higher cutoff criteria. With respect to antral follicle size, 61.5 % included follicles ranging between 2 and 10 mm in the AFC. When asked to identify the best predictor of ovarian hyper-response during IVF cycles, AFC was selected most frequently (49.4 %), followed by anti-Mullerian hormone level (42.7 %). Age was selected as the best predictor of ongoing pregnancy rate in 81.7 % of respondents. While a large proportion of respondents utilized AFC as part of their daily practice and modified IVF protocol based on the measurement, the majority did not consider AFC as the best predictor of ongoing pregnancy rate.

  2. Laparoscopy-Assisted Billroth I Gastrectomy for Ectopic Pancreas in the Prepyloric Region

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    Yueh-Tsung Lee

    2012-11-01

    Full Text Available Ectopic pancreatic tissue is an uncommon developmental anomaly. The condition mostly occurs in the gastrointestinal tract and is usually asymptomatic. It rarely causes symptoms of inflammation, bleeding and perforation, and has potential for malignant change. Though it is an uncommon condition, cases of ectopic pancreas have been reported worldwide. Preoperative diagnosis of ectopic pancreas is challenging because of its nonspecific symptoms and signs. Owing to the revolution of minimally invasive surgery, submucosal tumors of the stomach can be resected by laparoscopic techniques. We have earlier reported on a case of ectopic pancreas in the stomach treated by robotics-assisted laparoscopic wedge resection. Herein, we report a case of ectopic pancreas in the prepyloric region of the stomach. A 44-year-old female presented with a two-week history of epigastralgia with radiation to the back. She received endoscopy check-up which disclosed a mass in the stomach. By endoscopic findings, a submucosal lesion in the prepyloric region with umbilical folding on the mucosa was identified. The umbilical folding on the mucosa hint the orifice of the duct of ectopic pancreas into the gastric mucosa suggestive of ectopic pancreas. Contrast-enhanced abdominal computed tomography showed a 5 cm cystic mass with heterogeneous content. To sum it up, the patient was diagnosed as ectopic pancreas in the stomach. She underwent laparoscopy-assisted antrectomy with Billroth I anastomosis (excision of the antrum and prepyloric region with reconstruction of gastrointestinal continuity by gastroduodenostomy and had an uneventful hospitalization course. The histopathology of the resected tumor demonstrated ectopic pancreatic tissue in the gastric wall. To the best of our knowledge, excision of gastric ectopic pancreas using laparoscopy-assisted antrectomy with Billroth I anastomosis has never been reported in the literature.

  3. Intrathoracic drainage of a perforated prepyloric gastric ulcer with a type II paraoesophageal hernia

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    Zonneveld Bas JGL

    2008-12-01

    Full Text Available Abstract Background With an incidence of less than 5%, type II paraesophageal hernias are one of the less common types of hiatal hernias. We report a case of a perforated prepyloric gastric ulcer which, due to a type II hiatus hernia, drained into the mediastinum. Case presentation A 61-year old Caucasian man presented with acute abdominal pain. On a conventional x-ray of the chest a large mediastinal air-fluid collection and free intra-abdominal air was seen. Additional computed tomography revealed a large intra-thoracic air-fluid collection with a type II paraesophageal hernia. An emergency upper midline laparotomy was performed and a perforated pre-pyloric gastric ulcer was treated with an omental patch repair. The patient fully recovered after 10 days and continues to do well. Conclusion Type II paraesophageal hernia is an uncommon diagnosis. The main risk is gastric volvulus and possible gastric torsion. Intrathoracic perforation of gastric ulcers due to a type II hiatus hernia is extremely rare and can be a diagnostic and treatment challenge.

  4. How Patients Experience Antral Irrigation

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    Karin Blomgren

    2015-01-01

    Full Text Available Background Antral irrigation earlier had an important role in the diagnosis and treatment of rhinosinusitis. Nowadays, it is often considered too unpleasant. However, the experience of patients of this procedure has been very seldom evaluated. Nor has the effect on pain in rhinosinusitis been evaluated. The aim of this study was to evaluate patients’ experience of discomfort and pain during antral irrigation. We also assessed facial pain caused by rhinosinusitis before the procedure and pain soon after the procedure. Methods Doctors and 121 patients completed their questionnaires independently after antral irrigation in a university clinic, in a private hospital, and at a communal health center. Results Patients experienced mild pain during antral irrigation (mean and median visual analog scale score: <3. Their experience of pain during antral irrigation was closely comparable to pain during dental calculus scaling. Facial pain assessed before antral irrigation decreased quickly after the procedure. Conclusions Antral irrigation was well tolerated as an outpatient procedure. The procedure seems to relieve facial pain caused by the disease quickly. The role of antral irrigation in the treatment of acute rhinosinusitis will need further investigation.

  5. Laparoscopic treatment of heterotopic pancreas in the prepyloric region

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    Galvez-Valdovinos R

    2006-01-01

    Full Text Available Heterotopic pancreas is a rare condition and its diagnosis is often difficult. Traditionally the condition is treated by open surgery. We report two young women with symptomatic heterotopic pancreas located in the prepyloric region. In the first patient, upper gastrointestinal endoscopy identified a round sessile lesion with a central umbilication of the mucosa without bleeding and in the second endoscopy showed a lesion with intraluminal protrusion. In both cases, a diagnostic laparoscopy identified masses amenable to laparoscopic excision. Intraoperative histology confirmed ectopic pancreatic tissue in both. In the treatment of heterotopic pancreas, laparoscopic excision provides a feasible, safe and effective treatment option.

  6. Relationship between ultrasonically detected phasic antral contractions and antral pressure.

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    Hveem, K; Sun, W M; Hebbard, G; Horowitz, M; Doran, S; Dent, J

    2001-07-01

    The relationships between gastric wall motion and intraluminal pressure are believed to be major determinants of flows within and from the stomach. Gastric antral wall motion and intraluminal pressures were monitored in five healthy subjects by concurrent antropyloroduodenal manometry and transabdominal ultrasound for 60 min after subjects drank 500 ml of clear soup. We found that 99% of antral contractions detected by ultrasound were propagated aborally, and 68% of contractions became lumen occlusive at the site of the ultrasound marker. Of the 203 contractions detected by ultrasound, 53% were associated with pressure events in the manometric reference channel; 86% of contractions had corresponding pressure events detectable somewhere in the antrum. Contractions that occluded the lumen were more likely to be associated with a pressure event in the manometric reference channel (P < 0.01) and to be of greater amplitude (P < 0.01) than non-lumen-occlusive contractions. We conclude that heterogeneous pressure event patterns in the antrum occur despite a stereotyped pattern of contraction propagation seen on ultrasound. Lumen occlusion is more likely to be associated with higher peak antral pressure events.

  7. Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles

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    Hannon, Patrick R., E-mail: phannon2@illinois.edu; Brannick, Katherine E., E-mail: kbran@illinois.edu; Wang, Wei, E-mail: Wei.Wang2@covance.com; Gupta, Rupesh K., E-mail: drrupesh@yahoo.com; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2015-04-01

    Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant found in consumer products that causes ovarian toxicity. Antral follicles are the functional ovarian units and must undergo growth, survival from atresia, and proper regulation of steroidogenesis to ovulate and produce hormones. Previous studies have determined that DEHP inhibits antral follicle growth and decreases estradiol levels in vitro; however, the mechanism by which DEHP elicits these effects is unknown. The present study tested the hypothesis that DEHP directly alters regulators of the cell cycle, apoptosis, and steroidogenesis to inhibit antral follicle functionality. Antral follicles from adult CD-1 mice were cultured with vehicle control or DEHP (1–100 μg/ml) for 24–96 h to establish the temporal effects of DEHP on the follicle. Following 24–96 h of culture, antral follicles were subjected to gene expression analysis, and media were subjected to measurements of hormone levels. DEHP increased the mRNA levels of cyclin D2, cyclin dependent kinase 4, cyclin E1, cyclin A2, and cyclin B1 and decreased the levels of cyclin-dependent kinase inhibitor 1A prior to growth inhibition. Additionally, DEHP increased the mRNA levels of BCL2-associated agonist of cell death, BCL2-associated X protein, BCL2-related ovarian killer protein, B-cell leukemia/lymphoma 2, and Bcl2-like 10, leading to an increase in atresia. Further, DEHP decreased the levels of progesterone, androstenedione, and testosterone prior to the decrease in estradiol levels, with decreased mRNA levels of side-chain cleavage, 17α-hydroxylase-17,20-desmolase, 17β-hydroxysteroid dehydrogenase, and aromatase. Collectively, DEHP directly alters antral follicle functionality by inhibiting growth, inducing atresia, and inhibiting steroidogenesis. - Highlights: • DEHP inhibits antral follicle growth by dysregulating cell cycle regulators. • DEHP induces antral follicle atresia by dysregulating apoptosis regulators. • DEHP

  8. Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles

    International Nuclear Information System (INIS)

    Hannon, Patrick R.; Brannick, Katherine E.; Wang, Wei; Gupta, Rupesh K.; Flaws, Jodi A.

    2015-01-01

    Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant found in consumer products that causes ovarian toxicity. Antral follicles are the functional ovarian units and must undergo growth, survival from atresia, and proper regulation of steroidogenesis to ovulate and produce hormones. Previous studies have determined that DEHP inhibits antral follicle growth and decreases estradiol levels in vitro; however, the mechanism by which DEHP elicits these effects is unknown. The present study tested the hypothesis that DEHP directly alters regulators of the cell cycle, apoptosis, and steroidogenesis to inhibit antral follicle functionality. Antral follicles from adult CD-1 mice were cultured with vehicle control or DEHP (1–100 μg/ml) for 24–96 h to establish the temporal effects of DEHP on the follicle. Following 24–96 h of culture, antral follicles were subjected to gene expression analysis, and media were subjected to measurements of hormone levels. DEHP increased the mRNA levels of cyclin D2, cyclin dependent kinase 4, cyclin E1, cyclin A2, and cyclin B1 and decreased the levels of cyclin-dependent kinase inhibitor 1A prior to growth inhibition. Additionally, DEHP increased the mRNA levels of BCL2-associated agonist of cell death, BCL2-associated X protein, BCL2-related ovarian killer protein, B-cell leukemia/lymphoma 2, and Bcl2-like 10, leading to an increase in atresia. Further, DEHP decreased the levels of progesterone, androstenedione, and testosterone prior to the decrease in estradiol levels, with decreased mRNA levels of side-chain cleavage, 17α-hydroxylase-17,20-desmolase, 17β-hydroxysteroid dehydrogenase, and aromatase. Collectively, DEHP directly alters antral follicle functionality by inhibiting growth, inducing atresia, and inhibiting steroidogenesis. - Highlights: • DEHP inhibits antral follicle growth by dysregulating cell cycle regulators. • DEHP induces antral follicle atresia by dysregulating apoptosis regulators. • DEHP

  9. HUBUNGAN JUMLAH FOLIKEL ANTRAL DENGAN RESPONS OVARIUM TERHADAP STIMULASI OVULASI

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    I B Putra Adnyana

    2012-11-01

    Full Text Available Penelitian-penelitian menunjukkan adanya kemungkinan untuk memprediksi respons ovarium terhadap stimulasi ovulasi. Faktor-faktor yang mungkin dijadikan prediktor mencakup umur, volume ovarium, jumlah folikel antral, aliran darah stromal ovarium, dan petanda hormonal seperti Follicle Stimulating Hormone (FSH, estradiol (E2 dan Inhibin B. Hitung folikel antral adalah salah satu cara pemeriksaan kapasitas ovarium yang sederhana. Dibandingkan pemeriksaan petanda hormonal pemeriksaan folikel antral lebih sederhana, relatif lebih murah, dan hanya memerlukan sarana berupa alat ultrasonografi yang saat ini sudah tersedia secara luas dan penilaian hasilnya dapat dilakukan secara cepat. Mengetahui hubungan antara jumlah folikel antral dengan respons stimulasi ovulasi Seluruh wanita yang menjalani program FIV dengan stimulasi short protokol antara bulan Januari 2005 ? Mei 2006 disertakan dalam penelitian. Dilakukan pengumpulan data hitung folikel antral hari kedua, jumlah folikel matur, jumlah total oosit, jumlah oosit matur, dan total dosis gonadotropin. Dilakukan analisa Kendall?s correlation test untuk menunjukkan hubungan. Pada penelitian ini didapatkan hubungan yang bermakna antara hitung folikel antral dengan hitung folikel matur (r=0,329; p=0,037, jumlah total oosit (r=0,506; p=0,001, jumlah oosit matur (r=0,492; p=0,002, dan total dosis gonadotropin (r=-0,477; p=0,002. Penelitian ini menunjukkan bahwa terdapat hubungan yang bermakna antara hitung foliekl antral dengan respons ovarium terhadap stimulasi ovulasi dan didapatkan nilai titik potong hitung folikel antral sebesar 4,5.

  10. Antral hyperplastic polyp causing intermittent gastric outlet obstruction: Case report

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    Kurtkaya-Yapicier Ozlem

    2003-06-01

    Full Text Available Abstract Background Hyperplastic polyps are the most common polypoid lesions of the stomach. Rarely, they cause gastric outlet obstruction by prolapsing through the pyloric channel, when they arise in the prepyloric antrum. Case presentation A 62-year-old woman presented with intermittent nausea and vomiting of 4 months duration. Upper gastrointestinal endoscopy revealed a 30 mm prepyloric sessile polyp causing intermittent gastric outlet obstruction. Following submucosal injection of diluted adrenaline solution, the polyp was removed with a snare. Multiple biopsies were taken from the greater curvature of the antrum and the corpus. Rapid urease test for Helicobacter pylori yielded a negative result. Histopathologic examination showed a hyperplastic polyp without any evidence of malignancy. Biopsies of the antrum and the corpus revealed gastritis with neither atrophic changes nor Helicobacter pylori infection. Follow-up endoscopy after a 12-week course of proton pomp inhibitor therapy showed a complete healing without any remnant tissue at the polypectomy site. The patient has been symptom-free during 8 months of follow-up. Conclusions Symptomatic gastric polyps should be removed preferentially when they are detected at the initial diagnostic endoscopy. Polypectomy not only provides tissue to determine the exact histopathologic type of the polyp, but also achieves radical treatment.

  11. Gastritis crónica antral por Helicobacter pylori en la infancia Chronic antral gastritis induced by Helicobacter pylori in children

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    Martha M. Gámez Escalona

    2008-03-01

    Full Text Available INTRODUCCIÓN. La investigación tiene como objetivos conocer la frecuencia de infección por Helicobacter pylori en los niños con gastritis crónica antral, estimar las diferencias en el comportamiento histológico de esta entidad en los niños con infección por Helicobacter pylori y sin ella, e identificar la posible relación entre la edad y las características histológicas de la gastritis crónica antral por Helicobacter pylori. MÉTODO. Se tomó como universo de estudio la totalidad de biopsias gástricas procesadas en el Hospital Pediátrico Provincial de Holguín, entre enero de 1991 y diciembre del 2004. Se determinó una muestra de 192 niños con diagnóstico histológico de gastritis crónica antral. Las biopsias fueron reevaluadas para detectar infección por Helicobacter pylori y su densidad de colonización junto a la actividad y la gravedad de las lesiones de la gastritis. RESULTADOS. Se encontró infección por Helicobacter pylori en el 67,7 % de los pacientes. Las formas activas predominaron en los casos con infección por Helicobacter pylori (116/130 a diferencia de quienes no tenían infección (5/62. Se identificó una relación estadísticamente significativa (p INTRODUCTION. The objective of this investigation is to know the frequency of infection caused by Helicobacter pylori in children with chronic antral gastritis, to estimate the differences in the histological behavior of this entity in children with infection due to Helicobacter pylori and without it, and to identify the possible relation existing between age and the histgological characteristics of chronic antral gastritis caused by Helicobacter pylori. METHODS. All the gastric biopsies processed in the Provincial Pediatric Hospital of Holguin from January 1991 to December 2004 were included in the study group. A sample of 192 children with histological diagnosis of chronic antral gastritis was determined. The biopsies were reevaluated to detect Helicobacter

  12. Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome.

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    Smith, Elliot; Tekola, Bezawit; Patrie, James; Cornella, Scott; Caldwell, Stephen

    2016-12-01

    Gastric antral vascular ectasia is a relatively common endoscopic finding. Past studies have shown an association of gastric antral vascular ectasia with cirrhosis and autoimmune disorders. We aimed to re-examine these associations and to investigate a possible association of gastric antral vascular ectasia with features of the metabolic syndrome. There were 135 patients with a diagnosis of gastric antral vascular ectasia from years 1995-2013 seen at the University of Virginia who were identified from a clinical data repository and age and sex matched to a cohort of patients without gastric antral vascular ectasia undergoing endoscopy within the same time frame as the index cases. The groups were compared for comorbidities including autoimmune disease, cirrhosis, vascular disease, body mass index (BMI), diabetes mellitus, and cirrhosis due to nonalcoholic steatohepatitis. Sixty-four percent of gastric antral vascular ectasia patients were cirrhotic, compared with 14% of controls (P correlation of gastric antral vascular ectasia with features of metabolic syndrome such as diabetes, BMI, vascular disease, and nonalcoholic steatohepatitis cirrhosis. The pathophysiology of gastric antral vascular ectasia remains uncertain, but we speculate that it may be a manifestation of the metabolic syndrome. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. BUCCAL ADVANCEMENT FLAP DAN ANTROSTOMI: UNTUK TERAPI ORO ANTRAL FISTULA (Laporan Kasus

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    Rizal Rivandi

    2015-08-01

    Full Text Available Buccal advancement flap is one of the many ways of treating oro antral fistula. This technique is frequently used by dentists because it is easier to do and has several advantages compared to other techniques. This paper reports a case of oro antral fistula caused by complication of a tooth extraction, with discussions about definition, ethics and other therapies of oro antral fistula.

  14. Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling.

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    Berry, Rachel; Miyagawa, Taimei; Paskaranandavadivel, Niranchan; Du, Peng; Angeli, Timothy R; Trew, Mark L; Windsor, John A; Imai, Yohsuke; O'Grady, Gregory; Cheng, Leo K

    2016-11-01

    High-resolution (HR) mapping has been used to study gastric slow-wave activation; however, the specific characteristics of antral electrophysiology remain poorly defined. This study applied HR mapping and computational modeling to define functional human antral physiology. HR mapping was performed in 10 subjects using flexible electrode arrays (128-192 electrodes; 16-24 cm 2 ) arranged from the pylorus to mid-corpus. Anatomical registration was by photographs and anatomical landmarks. Slow-wave parameters were computed, and resultant data were incorporated into a computational fluid dynamics (CFD) model of gastric flow to calculate impact on gastric mixing. In all subjects, extracellular mapping demonstrated normal aboral slow-wave propagation and a region of increased amplitude and velocity in the prepyloric antrum. On average, the high-velocity region commenced 28 mm proximal to the pylorus, and activation ceased 6 mm from the pylorus. Within this region, velocity increased 0.2 mm/s per mm of tissue, from the mean 3.3 ± 0.1 mm/s to 7.5 ± 0.6 mm/s (P human terminal antral contraction is controlled by a short region of rapid high-amplitude slow-wave activity. Distal antral wave acceleration plays a major role in antral flow and mixing, increasing particle strain and trituration. Copyright © 2016 the American Physiological Society.

  15. Novel sonographic clues for diagnosis of antral gastritis and Helicobacter pylori infection: a clinical study.

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    Cakmakci, Emin; Ucan, Berna; Colak, Bayram; Cinar, Hasibe Gokçe

    2014-09-01

    The purpose of this study was to find out whether transabdominal sonography may have a predictive role for detection of antral gastritis and Helicobacter pylori infection in the antrum. A total of 108 patients and 54 control participants were allocated into 3 groups: group 1, controls without any symptoms or findings of antral gastritis and H pylori infection; group 2, patients with symptoms and endoscopic findings consistent with gastritis in the absence of documented H pylori infection; and group 3, patients with symptoms and endoscopic findings consistent with gastritis and documented H pylori infection. These groups were compared in terms of demographics, antral wall thickness, mucosal layer (together with muscularis mucosa) thickness, and mucosal layer-to-antral wall thickness ratio. The groups had no statistically significant differences with respect to age, sex, body mass index, and smoking habits. However, it turned out that both antral walls and muscularis mucosa layers were thicker and the mucosal layer-to-antral wall thickness ratio was higher in groups 2 and 3 compared to group 1 (P > .001). In addition, group 3 had statistically significantly thicker antral walls and muscularis mucosa layers and a significantly increased mucosal layer-to-antral wall thickness ratio than group 2 (P gastritis caused by H pylori infection is associated with characteristic features such as thickening of antral walls and mucosal layers on sonography. These novel clues may be useful in the diagnosis of gastritis, and unnecessary interventions and measures can be avoided in some cases. © 2014 by the American Institute of Ultrasound in Medicine.

  16. Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

    International Nuclear Information System (INIS)

    Patel, Shreya; Peretz, Jackye; Pan, Yuan-Xiang; Helferich, William G.; Flaws, Jodi A.

    2016-01-01

    Genistein is a naturally occurring isoflavone phytoestrogen commonly found in plant products such as soybeans, lentils, and chickpeas. Genistein, like other phytoestrogens, has the potential to mimic, enhance, or impair the estradiol biosynthesis pathway, thereby potentially altering ovarian follicle growth. Previous studies have inconsistently indicated that genistein exposure may alter granulosa cell proliferation and hormone production, but no studies have examined the effects of genistein on intact antral follicles. Thus, this study was designed to test the hypothesis that genistein exposure inhibits follicle growth and steroidogenesis in intact antral follicles. To test this hypothesis, antral follicles isolated from CD-1 mice were cultured with vehicle (dimethyl sulfoxide; DMSO) or genistein (6.0 and 36 μM) for 18–96 h. Every 24 h, follicle diameters were measured to assess growth. At the end of each culture period, the media were pooled to measure hormone levels, and the cultured follicles were collected to measure expression of cell cycle regulators and steroidogenic enzymes. The results indicate that genistein (36 μM) inhibits growth of mouse antral follicles. Additionally, genistein (6.0 and 36 μM) increases progesterone, testosterone, and dehydroepiandrosterone (DHEA) levels, but decreases estrone and estradiol levels. The results also indicate that genistein alters the expression of steroidogenic enzymes at 24, 72 and 96 h, and the expression of cell cycle regulators at 18 h. These data indicate that genistein exposure inhibits antral follicle growth by inhibiting the cell cycle, alters sex steroid hormone levels, and dysregulates steroidogenic enzymes in cultured mouse antral follicles. - Highlights: • Genistein exposure inhibits antral follicle growth. • Genistein exposure alters expression of cell cycle regulators. • Genistein exposure alters sex steroid hormones. • Genistein exposure alters expression of steroidogenic enzymes.

  17. Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

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    Patel, Shreya, E-mail: Shreya.patel214@gmail.com [Department of Comparative Biosciences, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States); Peretz, Jackye, E-mail: Jackye.peretz@gmail.com [Department of Comparative Biosciences, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States); Pan, Yuan-Xiang, E-mail: yxpan@illinois.edu [Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin, Urbana, IL 61801 (United States); Helferich, William G., E-mail: helferic@illinois.edu [Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin, Urbana, IL 61801 (United States); Flaws, Jodi A., E-mail: jflaws@illinois.edu [Department of Comparative Biosciences, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States)

    2016-02-15

    Genistein is a naturally occurring isoflavone phytoestrogen commonly found in plant products such as soybeans, lentils, and chickpeas. Genistein, like other phytoestrogens, has the potential to mimic, enhance, or impair the estradiol biosynthesis pathway, thereby potentially altering ovarian follicle growth. Previous studies have inconsistently indicated that genistein exposure may alter granulosa cell proliferation and hormone production, but no studies have examined the effects of genistein on intact antral follicles. Thus, this study was designed to test the hypothesis that genistein exposure inhibits follicle growth and steroidogenesis in intact antral follicles. To test this hypothesis, antral follicles isolated from CD-1 mice were cultured with vehicle (dimethyl sulfoxide; DMSO) or genistein (6.0 and 36 μM) for 18–96 h. Every 24 h, follicle diameters were measured to assess growth. At the end of each culture period, the media were pooled to measure hormone levels, and the cultured follicles were collected to measure expression of cell cycle regulators and steroidogenic enzymes. The results indicate that genistein (36 μM) inhibits growth of mouse antral follicles. Additionally, genistein (6.0 and 36 μM) increases progesterone, testosterone, and dehydroepiandrosterone (DHEA) levels, but decreases estrone and estradiol levels. The results also indicate that genistein alters the expression of steroidogenic enzymes at 24, 72 and 96 h, and the expression of cell cycle regulators at 18 h. These data indicate that genistein exposure inhibits antral follicle growth by inhibiting the cell cycle, alters sex steroid hormone levels, and dysregulates steroidogenic enzymes in cultured mouse antral follicles. - Highlights: • Genistein exposure inhibits antral follicle growth. • Genistein exposure alters expression of cell cycle regulators. • Genistein exposure alters sex steroid hormones. • Genistein exposure alters expression of steroidogenic enzymes.

  18. Applying ultrasonographic evaluation of antral follicle count to improve reproductive management in heifers

    Science.gov (United States)

    Ultrasonography is a powerful technology that can be used to improve reproductive management in heifers. By counting the number of antral follicles observed on an ultrasound screen the practitioner can gather additional information when reproductive tract scoring, because the number of antral folli...

  19. Radiologic findings of gastric antral vascular ectasia (watermelon stomach): a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joo Chang; Park, Kil Sun; Han, Gi Seok; Cha, Sang Hoon; Kim, Sung Jin; Kim, Dae Young [Chungbuk National Univ. College of Medicine, Cheongjushi (Korea, Republic of)

    1999-01-01

    Gastric antral vascular ectasia (watermelon stomach) is characterized by a prominent longitudinal erythematous fold of gastric antrum. Because it has usually been diagnosed by gastroscopy and biopsy, its radiologic findings have not been well described. We report a case of gastric antral vascular ectasia, and describe its findings, as seen on UGIS, ultrasonography, and computed tomography.

  20. Radiologic findings of gastric antral vascular ectasia (watermelon stomach): a case report

    International Nuclear Information System (INIS)

    Kim, Joo Chang; Park, Kil Sun; Han, Gi Seok; Cha, Sang Hoon; Kim, Sung Jin; Kim, Dae Young

    1999-01-01

    Gastric antral vascular ectasia (watermelon stomach) is characterized by a prominent longitudinal erythematous fold of gastric antrum. Because it has usually been diagnosed by gastroscopy and biopsy, its radiologic findings have not been well described. We report a case of gastric antral vascular ectasia, and describe its findings, as seen on UGIS, ultrasonography, and computed tomography

  1. Zygomatic bone graft for oral-antral communication closure and implant placement.

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    Peñarrocha-Diago, Miguel; García, Berta; Gomez, Dolores; Balaguer, José

    2007-01-01

    The roots of molar and premolar maxillary teeth are often very close to the floor of the maxillary sinus. As a result, extraction of these teeth can leave an oral-antral communication or lead to a fistula that requires treatment. A woman with an oral-antral communication secondary to extraction of a maxillary molar is presented. The communication was closed by means of a bone graft harvested from the wall of the sinus (zygomatic bone). After 3 months, 2 dental implants were placed, one in the pterygoid area and the other with parasinusal angulation. Rehabilitation followed in the form of a screw-retained, fixed prosthesis 3 months after implant placement. There have been no complications after 1 year of follow-up. This surgical technique allowed closure of an oral-antral communication produced by molar extraction through placement of a zygomatic bone graft and subsequent placement of 2 dental implants.

  2. Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles.

    Science.gov (United States)

    Hernández-Coronado, C G; Guzmán, A; Espinosa-Cervantes, R; Romano, M C; Verde-Calvo, J R; Rosales-Torres, A M

    2015-02-01

    The follicle destiny towards ovulation or atresia is multi-factorial in nature and involves outcries, paracrine and endocrine factors that promote cell proliferation and survival (development) or unchain apoptosis as part of the atresia process. In several types of cells, sphingosine-1-phospate (S1P) promotes cellular proliferation and survival, whereas ceramide (CER) triggers cell death, and the S1P/CER ratio may determine the fate of the cell. The aim of present study was to quantify S1P and CER concentrations and their ratio in bovine antral follicles of 8 to 17 mm classified as healthy and atretic antral follicles. Follicles were dissected from cow ovaries collected from a local abattoir. The theca cell layer, the granulosa cells and follicular fluid were separated, and 17β-estradiol (E2) and progesterone (P4) concentrations were measured in the follicular fluid by radioimmunoassay. Based on the E2/P4 ratio, the follicles were classified as healthy (2.2±0.3) or atretic (0.2±0.3). In both follicular compartments (granulosa and theca cell layer), sphingolipids were extracted and S1P and CER concentrations were quantified by HPLC (XTerra RP18; 5 µm, 3.0×150 mm column). Results showed that in both follicular compartments, S1P concentrations were higher in healthy antral follicles than in atretic antral follicles (P<0.05). The concentration of CER in the granulosa cells was higher in atretic antral follicles than in healthy antral follicles, but no differences were observed in the theca cell layer. The S1P/CER ratio in both follicular compartments was also higher in healthy antral follicles. Interestingly, in these follicles, there was a 45-fold greater concentration of S1P than CER in the granulosa cells (P<0.05), whereas in the theca cell layer, S1P had only a 14-fold greater concentration than CER when compared with atretic antral follicles. These results suggest that S1P plays a role in follicle health, increasing cellular proliferation and survival. In

  3. Comparison of relationship between antral floor and maxillary root apex in bisecting and panoramic techniques

    International Nuclear Information System (INIS)

    You, Dong Soo; Kim, In Soo

    1986-01-01

    This study was performed to compare the difference of intraoral bisecting and panoramic techniques in evaluating the relationship of antral floor and maxillary roots. The vertical distances form maxillary root apices to antral floor were measured on both orthopantomograms and bisecting projections obtained form fifth subjects. The results were as follows: 1. Tooth lengths measured on orthopantomogram were larger than on bisecting projection and the magnification ratios were 1.08-1.17. 2. The dimensions from maxillary root apices to antral floor measured on orthopantomogram were larger than on bisecting projection. 3. The above results held true regardless of age and sex.

  4. Influence of puberty and antral follicle count on calving day in crossbred beef heifers.

    Science.gov (United States)

    McNeel, Anthony K; Cushman, Robert A

    2015-10-15

    Lifetime productivity and longevity are greater in beef cows that give birth early in their first calving season. The ability of heifers to conceive early in the breeding season is traditionally thought to be a function of pubertal status; however, recent evidence suggests that antral follicle count is positively associated with calving day in pubertal beef heifers. Additionally, there is evidence to suggest that the total number of ovarian follicles may alter response to hormonal synchronization protocols. The objectives of this study were to confirm the beneficial influence of antral follicle count on calving day in beef heifers and to determine whether response to PGF2α is associated with differences in antral follicle counts. A 2 × 2 factorial experiment was designed to investigate the interaction between calving period (early vs. late) and PGF2α (control vs. PGF) on calving day and antral follicle count in yearling beef heifers (n = 95). As intended, calving day was less in the early calving period compared to the late calving period (P 0.05). There was a significant interaction between calving period and PGF2α on age at first calving (P reproductive tract scoring for commercial production because of its association with calving day. As a prebreeding ovarian phenotype, antral follicle counts may hold additional applicability for organic beef producers looking to reduce the length of their calving season without increasing the total number of replacement heifers retained. Published by Elsevier Inc.

  5. Dopaminergic and beta-adrenergic effects on gastric antral motility

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P; Gottrup, F

    1984-01-01

    of bethanechol or pentagastrin inducing motor activity patterns as in the phase III of the MMC and the digestive state respectively. The stimulated antral motility was dose-dependently inhibited by dopamine. The effect was significantly blocked by specifically acting dopaminergic blockers, while alpha- and beta......-adrenergic blockers were without any significant effects. Dose-response experiments with bethanechol and dopamine showed inhibition of a non-competitive type. Isoprenaline was used alone and in conjunction with selective blockade of beta 1- and beta 2-receptors during infusion of bethanechol which induces a pattern...... similar to phase III in the migrating myoelectric complex. The stimulated antral motility was dose-dependently inhibited by isoprenaline. The effect could be significantly blocked by propranolol (beta 1 + beta 2-adrenoceptor blocker) and by using in conjunction the beta 1-adrenoceptor blocker practolol...

  6. Effect of sildenafil on gastric emptying and postprandial frequency of antral contractions in healthy humans

    DEFF Research Database (Denmark)

    Madsen, Jan Lysgård; Søndergaard, S B; Fuglsang, Stefan

    2004-01-01

    BACKGROUND: Sildenafil is known to block phosphodiesterase type 5, which degrades nitric oxide-stimulated cyclic guanosine monophosphate, thereby relaxing smooth muscle cells in various organs. The effect of sildenafil on gastric motor function after a meal was investigated in healthy humans...... gastric emptying and postprandial frequency of antral contractions. RESULTS: The area under the curve of gastric retention versus time of liquid or solid radiolabelled marker was not changed by sildenafil intake, nor was the postprandial frequency of antral contractions affected by sildenafil. CONCLUSION......: A single dose of 50 mg sildenafil does not change gastric emptying or postprandial frequency of antral contractions in healthy volunteers....

  7. Reconstruction of highly contracted socket after irradiation with antral mucosa

    International Nuclear Information System (INIS)

    Tanabe, Yosihiko; Masaki, Michiyosi; Kato, Hisakazu

    1999-01-01

    We have repaired 3 cases of the highly contracted socket after irradiation by lining it using antral mucosa and obtained excellent results. Although this procedure requires rhinological skill to obtain the mucosa, it has an advantage leaving no visible scar at the donor site. Usually it is not difficult to obtain a sufficient quantity of the mucous membrane to line a whole socket from one antrum. Besides, it is also easy to line its surface since the shape of antral mucosa is originally in a sac form. All we have to do is making 20 mm long incision to the mucosa, putting a silicone conformer into it, and inlaying it into the graft bed. Thus, having once obtained the mucous membrane, the surgical procedure itself is a quite simple one. (author)

  8. Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

    International Nuclear Information System (INIS)

    Mahalingam, Sharada; Gao, Liying; Gonnering, Marni; Helferich, William; Flaws, Jodi A.

    2016-01-01

    Equol is a non-steroidal estrogen metabolite produced by microbial conversion of daidzein, a major soy isoflavone, in the gut of some humans and many animal species. Isoflavones and their metabolites can affect endogenous estradiol production, action, and metabolism, potentially influencing ovarian follicle function. However, no studies have examined the effects of equol on intact ovarian antral follicles, which are responsible for sex steroid synthesis and further development into ovulatory follicles. Thus, the present study tested the hypothesis that equol inhibits antral follicle growth, increases follicle atresia, and inhibits steroidogenesis in the adult mouse ovary. To test this hypothesis, antral follicles isolated from adult CD-1 mice were cultured with vehicle control (dimethyl sulfoxide; DMSO) or equol (600 nM, 6 μM, 36 μM, and 100 μM) for 48 and 96 h. Every 24 h, follicle diameters were measured to monitor growth. At 48 and 96 h, the culture medium was subjected to measurement of hormone levels, and the cultured follicles were subjected to gene expression analysis. Additionally, follicles were histologically evaluated for signs of atresia after 96 h of culture. The results indicate that equol (100 μM) inhibited follicle growth, altered the mRNA levels of bcl2-associated X protein and B cell leukemia/lymphoma 2, and induced follicle atresia. Further, equol decreased the levels of estradiol, testosterone, androstenedione, and progesterone, and it decreased mRNA levels of cholesterol side-chain cleavage, steroid 17-α-hydroxalase, and aromatase. Collectively, these data indicate that equol inhibits growth, increases atresia, and inhibits steroidogenesis of cultured mouse antral follicles. - Highlights: • Equol exposure inhibits antral follicle growth. • Equol exposure increases follicle atresia. • Equol exposure inhibits sex steroid hormone levels. • Equol exposure inhibits mRNA levels of certain steroidogenic enzymes.

  9. Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Mahalingam, Sharada, E-mail: mahalin2@illinois.edu [Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States); Gao, Liying, E-mail: lgao@uiuc.edu [Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States); Gonnering, Marni, E-mail: mgonne2@illinois.edu [Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States); Helferich, William, E-mail: helferic@illinois.edu [Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin, Urbana, IL 61801 (United States); Flaws, Jodi A., E-mail: jflaws@illinois.edu [Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, 2001 S. Lincoln Ave, Urbana, IL 61802 (United States)

    2016-03-15

    Equol is a non-steroidal estrogen metabolite produced by microbial conversion of daidzein, a major soy isoflavone, in the gut of some humans and many animal species. Isoflavones and their metabolites can affect endogenous estradiol production, action, and metabolism, potentially influencing ovarian follicle function. However, no studies have examined the effects of equol on intact ovarian antral follicles, which are responsible for sex steroid synthesis and further development into ovulatory follicles. Thus, the present study tested the hypothesis that equol inhibits antral follicle growth, increases follicle atresia, and inhibits steroidogenesis in the adult mouse ovary. To test this hypothesis, antral follicles isolated from adult CD-1 mice were cultured with vehicle control (dimethyl sulfoxide; DMSO) or equol (600 nM, 6 μM, 36 μM, and 100 μM) for 48 and 96 h. Every 24 h, follicle diameters were measured to monitor growth. At 48 and 96 h, the culture medium was subjected to measurement of hormone levels, and the cultured follicles were subjected to gene expression analysis. Additionally, follicles were histologically evaluated for signs of atresia after 96 h of culture. The results indicate that equol (100 μM) inhibited follicle growth, altered the mRNA levels of bcl2-associated X protein and B cell leukemia/lymphoma 2, and induced follicle atresia. Further, equol decreased the levels of estradiol, testosterone, androstenedione, and progesterone, and it decreased mRNA levels of cholesterol side-chain cleavage, steroid 17-α-hydroxalase, and aromatase. Collectively, these data indicate that equol inhibits growth, increases atresia, and inhibits steroidogenesis of cultured mouse antral follicles. - Highlights: • Equol exposure inhibits antral follicle growth. • Equol exposure increases follicle atresia. • Equol exposure inhibits sex steroid hormone levels. • Equol exposure inhibits mRNA levels of certain steroidogenic enzymes.

  10. Di (2-ethylhexyl Phthalate Exposure Impairs Growth of Antral Follicle in Mice.

    Directory of Open Access Journals (Sweden)

    Lan Li

    Full Text Available Di (2-ethylhexyl phthalate (DEHP is a widely used plastic additive. As an environmental endocrine disruptor, it has been shown to be harmful to the mammalian reproductive system. Previous studies indicated that DEHP inhibited the development of mouse ovarian follicles. However, the mechanisms by which DEHP affects ovarian antral follicle development during the pre-puberty stage are poorly understand. Thus, we investigated the effects of direct DEHP exposure on antral follicle growth in pre-pubescent mice by use of intraperitoneal injection. Our results demonstrated that the percentage of large antral follicles was significantly reduced when mice were exposed to 20 or 40 μg/kg DEHP every 5 days from postnatal day 0 (0 dpp to 15 dpp. In 20 dpp, we performed microarray of these ovaries. The microarray results indicated that mRNA levels of apoptosis related genes were increased. The mRNA levels of the apoptosis and cell proliferation (negative related genes Apoe, Agt, Glo1 and Grina were increased after DEHP exposure. DEHP induced the differential gene expression of Hsp90ab1, Rhoa, Grina and Xdh which may play an important role in this process. In addition, TUNEL staining and immunofluorescence showed that DEHP exposure significantly increased the number of TUNEL, Caspase3 and γH2AX positive ovarian somatic cells within the mouse ovaries. Flow cytometer analyses of redox-sensitive probes showed that DEHP caused the accumulation of reactive oxygen species. Moreover, the mRNA expression of ovarian somatic cell antioxidative enzymes was down-regulated both in vivo and in vitro. In conclusion, our data here demonstrated that DEHP exposure induced oxidative stress and ovarian somatic cell apoptosis, and thus may impact antral follicle enlargement during the pre-pubertal stage in mice.

  11. Effect of omeprazole and sucralfate on prepyloric gastric ulcer. A double blind comparative trial and one year follow up.

    Science.gov (United States)

    Sørensen, H T; Rasmussen, H H; Balslev, I; Boesby, S; Boné, J; Kruse, A; Rasmussen, S N

    1994-01-01

    This study compared healing rates, relief of symptoms, frequency of adverse events, and proportion of patients in remission after one year follow up in 104 patients with active prepyloric ulcer during treatment with 40 mg omeprazole once daily or 2 g sucralfate twice daily, using a randomised double blind controlled trial. Healing rates after two, four, and six weeks were (omeprazole/sucralfate) 49%/23%; 83%/59%; 90%/70% respectively. After two weeks, omeprazole was more efficient than sucralfate in relief of daytime and nocturnal epigastric pain, nausea, and heartburn. The proportion of patients in remission after one year follow up was significantly higher in the omeprazole group (p < 0.01). Of the healed patients ulcers recurred in 36% in the omeprazole group and in 46% in the sucralfate group. It is concluded that the ulcer healing rate was higher and symptom relief was more pronounced in the omeprazole group compared with the sucralfate group, and that more patients were still in remission after a one year follow up period. PMID:8020815

  12. Diffuse eosinophilic gastroenteritis with antral obstruction: a case report

    International Nuclear Information System (INIS)

    Moon, Sung Hee; Kim, Young Bok; Lee, Koung Hee

    2000-01-01

    Eosinophilic gastroenteritis is a rare disease characterized by tissue eosinophilia that can involve different layers of the gut wall and cause various gastrointestinal symptoms. We describe the UGI and CT findings of a case of diffuse eosinophilic gastroenteritis with tumor-like antral obstruction due to thickening of the submucosa and muscle layer in a 21-year-old male. (author)

  13. Diffuse eosinophilic gastroenteritis with antral obstruction: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Sung Hee; Kim, Young Bok; Lee, Koung Hee [National Police Hospital, Seoul (Korea, Republic of)

    2000-02-01

    Eosinophilic gastroenteritis is a rare disease characterized by tissue eosinophilia that can involve different layers of the gut wall and cause various gastrointestinal symptoms. We describe the UGI and CT findings of a case of diffuse eosinophilic gastroenteritis with tumor-like antral obstruction due to thickening of the submucosa and muscle layer in a 21-year-old male. (author)

  14. Hallmarks of Human Small Antral Follicle Development

    DEFF Research Database (Denmark)

    Kristensen, Stine G; Mamsen, Linn S; Jeppesen, Janni V

    2018-01-01

    Regulation of human ovarian steroidogenesis differs from other species and precise knowledge on how human small antral follicles (hSAF) develop and acquire competence for continued growth and steroid output is still incomplete. The present study has characterized almost 1,000 normal hSAF collected...... increased steroid output profoundly. Furthermore, the highly significant association between FSHR and AR mRNA gene expression enforces important functions of androgens in follicular development. Collectively, these data reintroduce the understanding of the follicular phase as two parted in which regulation...

  15. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.

    Directory of Open Access Journals (Sweden)

    Katarzyna Palus

    Full Text Available This experiment was designed to establish the localization and neurochemical phenotyping of sympathetic neurons supplying prepyloric area of the porcine stomach in a physiological state and during acetylsalicylic acid (ASA induced gastritis. In order to localize the sympathetic perikarya the stomachs of both control and acetylsalicylic acid treated (ASA group animals were injected with neuronal retrograde tracer Fast Blue (FB. Seven days post FB injection, animals were divided into a control and ASA supplementation group. The ASA group was given 100 mg/kg of b.w. ASA orally for 21 days. On the 28th day all pigs were euthanized with gradual overdose of anesthetic. Then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (TH, dopamine β-hydroxylase (DβH, neuropeptide Y (NPY, galanin (GAL, neuronal nitric oxide synthase (nNOS, leu 5-enkephalin (LENK, cocaine- and amphetamine- regulated transcript peptide (CART, calcitonin gene-related peptide (CGRP, substance P (SP and vasoactive intestinal peptide (VIP. The data obtained in this study indicate that postganglionic sympathetic nerve fibers supplying prepyloric area of the porcine stomach originate from the coeliac-cranial mesenteric ganglion complex (CCMG. In control animals, the FB-labelled neurons expressed TH (94.85 ± 1.01%, DβH (97.10 ± 0.97%, NPY (46.88 ± 2.53% and GAL (8.40 ± 0.53%. In ASA group, TH- and DβH- positive nerve cells were reduced (85.78 ± 2.65% and 88.82 ± 1.63% respectively. Moreover, ASA- induced gastritis resulted in increased expression of NPY (76.59 ± 3.02% and GAL (26.45 ± 2.75% as well as the novo-synthesis of nNOS (6.13 ± 1.11% and LENK (4.77 ± 0.42% in traced CCMG neurons. Additionally, a network of CART-, CGRP-, SP-, VIP-, LENK-, nNOS- immunoreactive (IR nerve fibers encircling the FB-positive perikarya were observed in both intact and ASA

  16. Ovarian volume and antral follicle count assessed by MRI and transvaginal ultrasonography: a methodological study.

    Science.gov (United States)

    Leonhardt, Henrik; Gull, Berit; Stener-Victorin, Elisabet; Hellström, Mikael

    2014-03-01

    Ultrasonographic measurements of ovarian volume and antral follicle count are of clinical importance as diagnostic features of polycystic ovarian syndrome (PCOS), and as a parameter in estimation of ovarian follicular reserve in infertility care. To compare two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) for estimation of ovarian volume and antral follicle count, and to assess reproducibility and inter-observer agreement of MRI measurements. Volumes of 172 ovaries in 99 women aged 21-37 years were calculated (length x width x height x 0.523) with conventional 2D TVUS and 2D MRI. Semi-automatic estimates of ovarian volumes were obtained by 3D MRI. Antral follicles were counted manually on 2D MRI and automatically by 3D TVUS (SonoAVC), and stratified according to follicle size. Mean ovarian volume assessed by 2D TVUS (13.1 ± 6.4 mL) was larger than assessed by 2D MRI (9.6 ± 4.1) and 3D MRI (11.4 ± 4.5) (P 0.77. 2D MRI reveals more antral follicles, especially of small size, than 3D TVUS. Ovarian volume estimation by MRI provides smaller volumes than by the reference standard 2D TVUS. Ovarian volume estimation by 3D MRI, allowing independence of non-ellipsoid ovarian shape measurement errors, provides volumes closer to 2D TVUS values than does 2D MRI. Reproducibility and inter-observer agreement of 2D MRI measurements of ovarian volume and total follicle count are good.

  17. Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei, E-mail: weiwang2@illinois.edu; Craig, Zelieann R., E-mail: zelieann@illinois.edu; Basavarajappa, Mallikarjuna S., E-mail: mbasava2@illinois.edu; Gupta, Rupesh K., E-mail: drrupesh@yahoo.com; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2012-01-15

    Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that has been shown to inhibit growth of mouse antral follicles, however, little is known about the mechanisms by which DEHP does so. Oxidative stress has been linked to follicle growth inhibition as well as phthalate-induced toxicity in non-ovarian tissues. Thus, we hypothesized that DEHP causes oxidative stress and that this leads to inhibition of the growth of antral follicles. To test this hypothesis, antral follicles isolated from CD-1 mice (age 31–35 days) were cultured with vehicle control (dimethylsulfoxide [DMSO]) or DEHP (1–100 μg/ml) ± N-acetyl cysteine (NAC, an antioxidant at 0.25–1 mM). During culture, follicles were measured daily. At the end of culture, follicles were collected and processed for in vitro reactive oxygen species (ROS) assays to measure the presence of free radicals or for measurement of the expression and activity of various key antioxidant enzymes: Cu/Zn superoxide dismutase (SOD1), glutathione peroxidase (GPX) and catalase (CAT). The results indicate that DEHP inhibits the growth of follicles compared to DMSO control and that NAC (0.25–1 mM) blocks the ability of DEHP to inhibit follicle growth. Furthermore, DEHP (10 μg/ml) significantly increases ROS levels and reduces the expression and activity of SOD1 compared to DMSO controls, whereas NAC (0.5 mM) rescues the effects of DEHP on ROS levels and SOD1. However, the expression and activity of GPX and CAT were not affected by DEHP treatment. Collectively, these data suggest that DEHP inhibits follicle growth by inducing production of ROS and by decreasing the expression and activity of SOD1. -- Highlights: ► DEHP inhibits growth and increases reactive oxygen species in ovarian antral follicles in vitro. ► NAC rescues the effects of DEHP on the growth and reactive oxygen species levels in follicles. ► DEHP decreases the expression and activity of Cu/Zn superoxide dismutase, which can be rescued by NAC, in antral

  18. Dioxin exposure reduces the steroidogenic capacity of mouse antral follicles mainly at the level of HSD17B1 without altering atresia

    Energy Technology Data Exchange (ETDEWEB)

    Karman, Bethany N., E-mail: bklement@illinois.edu; Basavarajappa, Mallikarjuna S., E-mail: mbshivapur@gmail.com; Hannon, Patrick, E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2012-10-01

    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent ovarian toxicant. Previously, we demonstrated that in vitro TCDD (1 nM) exposure decreases production/secretion of the sex steroid hormones progesterone (P4), androstenedione (A4), testosterone (T), and 17β-estradiol (E2) in mouse antral follicles. The purpose of this study was to determine the mechanism by which TCDD inhibits steroidogenesis. Specifically, we examined the effects of TCDD on the steroidogenic enzymes, atresia, and the aryl hydrocarbon receptor (AHR) protein. TCDD exposure for 48 h increased levels of A4, without changing HSD3B1 protein, HSD17B1 protein, estrone (E1), T or E2 levels. Further, TCDD did not alter atresia ratings compared to vehicle at 48 h. TCDD, however, did down regulate the AHR protein at 48 h. TCDD exposure for 96 h decreased transcript levels for Cyp11a1, Cyp17a1, Hsd17b1, and Cyp19a1, but increased Hsd3b1 transcript. TCDD exposure particularly lowered both Hsd17b1 transcript and HSD17B1 protein. However, TCDD exposure did not affect levels of E1 in the media nor atresia ratings at 96 h. TCDD, however, decreased levels of the proapoptotic factor Bax. Collectively, these data suggest that TCDD exposure causes a major block in the steroidogenic enzyme conversion of A4 to T and E1 to E2 and that it regulates apoptotic pathways, favoring survival over death in antral follicles. Finally, the down‐regulation of the AHR protein in TCDD exposed follicles persisted at 96 h, indicating that the activation and proteasomal degradation of this receptor likely plays a central role in the impaired steroidogenic capacity and altered apoptotic pathway of exposed antral follicles. -- Highlights: ► TCDD disrupts steroidogenic enzymes in mouse antral follicles. ► TCDD particularly affects the HSD17B1 enzyme in mouse antral follicles. ► TCDD does not affect atresia ratings in mouse antral follicles. ► TCDD decreases levels of the proapoptitic factor Bax in mouse antral follicles.

  19. Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia

    Directory of Open Access Journals (Sweden)

    Desiree Ji Re Lee

    2015-09-01

    Full Text Available AbstractWe observed a case of recombinant human erythropoietin resistance caused by Gastric Antral Vascular Ectasia in a 40-year-old female with ESRD on hemodialysis. Some associated factors such as autoimmune disease, hemolysis, heart and liver disease were discarded on physical examination and complementary tests. The diagnosis is based on the clinical history and endoscopic appearance of watermelon stomach. The histologic findings are fibromuscular proliferation and capillary ectasia with microvascular thrombosis of the lamina propria. However, these histologic findings are not necessary to confirm the diagnosis. Gastric Antral Vascular Ectasia is a serious condition and should be considered in ESRD patients on hemodialysis with anemia and resistance to recombinant human erythropoietin because GAVE is potentially curable with specific endoscopic treatment method or through surgical procedure.

  20. A Rare Presentation of Odontogenic Keratocyst Mimicking an Antral Polyp

    OpenAIRE

    Sudhakar, S; Geethika, V; Ramaswamy, P; Kumar, PK; Sreenivasulu, P

    2014-01-01

    Maxillary sinus harbours many pathological lesions. Many of those presents as a sinonasal mass and are rarely symptomatic. These masses are usually an antral polyp, mucoceles or mucous retention cysts. Odontogenic keratocyst, a benign odontogenic lesion presenting within the maxillary sinus is a rare entity. We present a case of odontogenic keratocyst of the maxillary sinus in a 35 years old female.

  1. Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.

    Science.gov (United States)

    Takeuchi, Koji; Tanaka, Akiko; Nukui, Kazuo; Kojo, Azusa; Gyenge, Melinda; Amagase, Kikuko

    2011-09-01

    Recent clinical studies have suggested a risk of adverse gastric reactions from the concomitant use of selective serotonin (5-HT) reuptake inhibitors (SSRIs) with nonsteroidal anti-inflammatory drugs (NSAIDs). We examined the adverse effects of SSRIs on antral lesions produced by indomethacin in rats. Rats fasted for 24 h were refed for 1 h, then administered indomethacin (30 mg/kg s.c.) 1 h after the refeeding and killed 6 h later. Paroxetine (1-10 mg/kg) was given orally 30 min before indomethacin. Indomethacin caused antral lesions in refed rats. Paroxetine dose-dependently aggravated these lesions, despite provoking no damage by itself. Similar results were obtained when other NSAIDs such as diclofenac, flurbiprofen, and loxoprofen were coadministered with paroxetine or when indomethacin was coadministered with other antidepressants such as fluvoxamine and milnacipran, but not imipramine or maprotiline. Exogenous 5-HT also worsened the indomethacin-induced antral damage, whereas the aggravating effect of paroxetine was attenuated by ondansetron, a selective 5-HT(3) antagonist, but not antagonists for other 5-HT receptor subtypes. Indomethacin plus paroxetine had no effect on gastric secretion but significantly decreased mucosal superoxide dismutase (SOD) activity as well as GSH content. The antral damage induced by indomethacin plus paroxetine was significantly prevented by antisecretory (acid or pepsin) agents and mucosal protective agents as well as SOD and allopurinol. These results suggest that SSRIs aggravate NSAID-induced antral lesions, probably via the activation of 5HT(3) receptors, and the mechanism of aggravation may involve the corrosive action of acid/pepsin as well as an impaired antioxidative system.

  2. A Rare Presentation of Odontogenic Keratocyst Mimicking an Antral Polyp

    Directory of Open Access Journals (Sweden)

    S Sudhakar

    2014-02-01

    Full Text Available Maxillary sinus harbours many pathological lesions. Many of those presents as a sinonasal mass and are rarely symptomatic. These masses are usually an antral polyp, mucoceles or mucous retention cysts. Odontogenic keratocyst, a benign odontogenic lesion presenting within the maxillary sinus is a rare entity. We present a case of odontogenic keratocyst of the maxillary sinus in a 35 years old female.

  3. Incidence of gastroesophageal reflux disease and positive maxillary antral cultures in children with symptoms of chronic rhinosinusitis.

    Science.gov (United States)

    Nation, Javan; Kaufman, Michael; Allen, Meredith; Sheyn, Anthony; Coticchia, James

    2014-02-01

    Studies have shown that gastroesophageal reflux disease occurs more frequently than expected in children with chronic rhinosinusitis. The objective of this study is to further understand the relationship of pediatric chronic rhinosinusitis and gastroesophageal reflux disease in children with symptoms of rhinorrhea, nasal congestion, and chronic cough. A retrospective chart review of 63 children, ages 6 months to 10 years old with rhinorrhea, nasal congestion, and chronic cough. The patients underwent maxillary cultures, adenoidectomy, and distal third esophageal biopsies. Children with esophageal biopsies showing esophagitis were classified as positive for gastroesophageal reflux disease, and maxillary antral swabs growing a high density of bacteria were classified as positive for chronic rhinosinusitis. Six months to 5 years old children (n=43), 6 (14%) had simultaneous positive maxillary antral cultures and positive esophageal biopsies, 11 (26%) had positive esophageal biopsies alone, 23 (53%) had positive maxillary antral cultures alone, and 3 (7%) had neither. Six to 10 years old children (n=20), 9 (45%) had simultaneous positive maxillary antral cultures and positive esophageal biopsies, 1 (5%) patient had positive esophageal biopsies alone, 3 (15%) patients had positive maxillary antral cultures alone, and 7 (35%) patients had neither. Twenty-seven (42%) of the patients from the whole study had gastroesophageal reflux positive biopsies. The younger children were statistically likely to have chronic rhinosinusitis and gastroesophageal reflux disease independently of each other (p=0.0002). A direct group comparison found the younger group to have independent chronic rhinosinusitis and gastroesophageal reflux disease and the older group to have simultaneous chronic rhinosinusitis and gastroesophageal reflux disease (p=0.0006). In children with the presenting symptoms of rhinorrhea, nasal congestion, and chronic cough, younger children tend to have either chronic

  4. Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.

    Science.gov (United States)

    Sawabe, Yukinori; Shimamoto, Chikao; Sakai, Akiko; Kuwabara, Hiroko; Saad, Adel H; Nakano, Takashi; Takitani, Kimitaka; Tamai, Hiroshi; Mori, Hiroshi; Marunaka, Yoshinori; Nakahari, Takashi

    2010-08-01

    Indomethacin (IDM, 10 microm), not aspirin (ASA; 10 microm), enhanced the Ca(2+)-regulated exocytosis stimulated by 1 microm acetylcholine (ACh) in guinea-pig antral mucous cells. Indomethacin inhibits prostaglandin G/H (PGG/H) and 15R-hydroperoxy-eicosatetraenoic acid (15R-HPETE) production from arachidonic acid (AA), while ASA inhibits PGG/H production but accelerates 15R-HPETE production. This suggests that IDM accumulates AA. Arachidonic acid (2 microm) enhanced Ca(2+)-regulated exocytosis in antral mucous cells to a similar extent to IDM. Moreover, a stable analogue of AA, arachidonyltrifluoromethyl ketone (AACOCF(3)), also enhanced Ca(2+)-regulated exocytosis, indicating that AA, not products from AA, enhances Ca(2+)-regulated exocytosis. We hypothesized that AA activates peroxisome proliferation activation receptor alpha (PPARalpha), because AA is a natural ligand for PPARalpha. A PPARalpha agonist (WY14643; 1 microm) enhanced Ca(2+)-regulated exocytosis, and a PPARalpha blocker (MK886; 50 microm) abolished the enhancement of Ca(2+)-regulated exocytosis induced by AA, IDM, AACOCF(3) and WY14643. Western blotting and immunohistochemical examinations demonstrated that PPARalpha exists in antral mucous cells. Moreover, MK886 decreased the frequency of Ca(2+)-regulated exocytosis activated by 1 microm ACh or 2 microm thapsigargin alone by 25-30%. Thus, ACh stimulates AA accumulation via an [Ca(2+)](i) increase, which activates PPARalpha, leading to enhancement of Ca(2+)-regulated exocytosis in antral mucous cells. A novel autocrine mechanism mediated via PPARalpha enhances Ca(2+)-regulated exocytosis in guinea-pig antral mucous cells.

  5. Epithelial cell proliferation in human fundic and antral mucosae. Influence of superselective vagotomy and relationship with gastritis

    International Nuclear Information System (INIS)

    Gutierrez, O.; Lehy, T.; Rene, E.; Gres, L.; Bonfils, S.

    1985-01-01

    Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se

  6. Intra-antral application of an anti-fungal agent for recurrent maxillary fungal rhinosinusitis: a case report

    Directory of Open Access Journals (Sweden)

    Dunmade Adekunle D

    2012-08-01

    Full Text Available Abstract Introduction Fungal infection of the paranasal sinuses is an increasingly recognized entity both in immunocompetent and immunocompromised individuals. Treatment has been via use of either surgical or medical modalities, or a combination of the two. Here, we present a case of utilization of intra-antral application of an anti-fungal agent in the management of recurrent fungal sinusitis in an indigent Nigerian patient. Case presentation We present the case of a 30-year-old West African Yoruba man, an indigent Nigerian clergyman, who presented to our facility with a history of recurrent nasal discharge (about one year, recurrent nasal blockage (about five months, and right facial swelling (about one week. After intra-nasal antrostomy for debulking with a systemic anti-fungal agent, our patient had a recurrence after four months. Our patient subsequently had an intra-antral application of flumetasone and clioquinol (Locacorten®-Vioform® weekly for six weeks with improvement of symptoms and no recurrence after six months of follow-up. Conclusions We conclude that topical intra-antral application of anti-fungal agents is effective in patients with recurrent fungal maxillary sinusitis after surgical debulking.

  7. The Distribution of Stroma and Antral Follicles Differs between Insulin-Resistance and Hyperandrogenism-Related Polycystic Ovarian Syndrome

    DEFF Research Database (Denmark)

    Alviggi, Carlo; Conforti, Alessandro; De Rosa, Pasquale

    2017-01-01

    groups based on specific transvaginal ultrasound parameters: subjects with more than half of the follicles measuring between 5 and 9 mm in diameter, an ultrasonographic determined stroma/total area (S/A) > 0.34 and a "necklace" sign of antral follicles (Group A); and subjects with more than half...... of the antral follicles measuring between 2 and 4 mm in diameter, an S/A ≤ 0.34; no "necklace" sign but ubiquitously distributed follicles determined by ultrasound (Group B). The association between these ultrasound patterns and the presence of insulin resistance was also evaluated. RESULTS: Seventy...

  8. Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro

    International Nuclear Information System (INIS)

    Gupta, Rupesh K.; Singh, Jeffery M.; Leslie, Tracie C.; Meachum, Sharon; Flaws, Jodi A.; Yao, Humphrey H-C

    2010-01-01

    Any insult that affects survival of ovarian antral follicles can cause abnormal estradiol production and fertility problems. Phthalate esters (PEs) are plasticizers used in a wide range of consumer and industrial products. Exposure to these chemicals has been linked to reduced fertility in humans and animal models. Di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) decrease serum estradiol levels and aromatase (Arom) expression, prolong estrous cycles, and cause anovulation in animal and culture models. These observations suggest PEs directly target antral follicles. We therefore tested the hypothesis that DEHP (1-100 μg/ml) and MEHP (0.1-10 μg/ml) directly inhibit antral follicular growth and estradiol production. Antral follicles from adult mice were cultured with DEHP or MEHP, and/or estradiol for 96 h. During culture, follicle size was measured every 24 h as a measurement of follicle growth. After culture, media were collected for measurement of estradiol levels and follicles were subjected to measurement of cylin-D-2 (Ccnd2), cyclin-dependant-kinase-4 (Cdk4), and Arom. We found that DEHP and MEHP inhibited growth of follicles and decreased estradiol production compared to controls at the highest doses. DEHP and MEHP also decreased mRNA expression of Ccnd2, Cdk4, and Arom at the highest dose. Addition of estradiol to the culture medium prevented the follicles from DEHP- and MEHP-induced inhibition of growth, reduction in estradiol levels, and decreased Ccnd2 and Cdk4 expression. Collectively, our results indicate that DEHP and MEHP may directly inhibit antral follicle growth via a mechanism that partially includes reduction in levels of estradiol production and decreased expression of cell cycle regulators.

  9. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

    OpenAIRE

    Peretz, Jackye; Flaws, Jodi A.

    2013-01-01

    Bisphenol A (BPA) is the backbone of polycarbonate plastic products and the epoxy resin lining of aluminum cans. Previous studies have shown that exposure to BPA decreases sex steroid hormone production in mouse antral follicles. The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex s...

  10. 2,3,7,8-Tetrachlorodibenzo-p-dioxin activates the aryl hydrocarbon receptor and alters sex steroid hormone secretion without affecting growth of mouse antral follicles in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Karman, Bethany N., E-mail: bklement@illinois.edu; Basavarajappa, Mallikarjuna S., E-mail: mbshivapur@gmail.com; Craig, Zelieann R., E-mail: zelieann@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2012-05-15

    The persistent environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an ovarian toxicant. These studies were designed to characterize the actions of TCDD on steroidogenesis and growth of intact mouse antral follicles in vitro. Specifically, these studies tested the hypothesis that TCDD exposure leads to decreased sex hormone production/secretion by antral follicles as well as decreased growth of antral follicles in vitro. Since TCDD acts through binding to the aryl hydrocarbon receptor (AHR), and the AHR has been identified as an important factor in ovarian function, we also conducted experiments to confirm the presence and activation of the AHR in our tissue culture system. To do so, we exposed mouse antral follicles for 96 h to a series of TCDD doses previously shown to have effects on ovarian tissues and cells in culture, which also encompass environmentally relevant and pharmacological exposures (0.1–100 nM), to determine a dose response for TCDD in our culture system for growth, hormone production, and expression of the Ahr and Cyp1b1. The results indicate that TCDD decreases progesterone, androstenedione, testosterone, and estradiol levels in a non-monotonic dose response manner without altering growth of antral follicles. The addition of pregnenolone substrate (10 μM) restores hormone levels to control levels. Additionally, Cyp1b1 levels were increased by 3–4 fold regardless of the dose of TCDD exposure, evidence of AHR activation. Overall, these data indicate that TCDD may act prior to pregnenolone formation and through AHR transcriptional control of Cyp1b1, leading to decreased hormone levels without affecting growth of antral follicles. -- Highlights: ►TCDD disrupts sex steroid hormone levels, but not growth of antral follicles. ►Pregnenolone co-treatment by-passes TCDD-induced steroid hormone disruption. ►TCDD affects steroid hormone levels through an AHR pathway in antral follicles.

  11. Effect of isoprenaline on bethanechol-stimulated gastric antral motility in dogs with gastric fistula

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P

    1982-01-01

    The purpose of the present study was to evaluate the effect of isoprenaline on gastric antral motility in conscious dogs with gastric fistula, using intraluminal strain-gauge transducers. Infusion of bethanechol increased the motility for both frequency and strength. Isoprenaline, a beta 1...

  12. Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P; Andersen, D

    1982-01-01

    The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous...

  13. Influence of antral follicle size on oocyte characteristics and embryo development in the bovine

    DEFF Research Database (Denmark)

    Lequarre, Anne Sophie; Vigneron, Céline; Ribaucour, Fabrice

    2005-01-01

    The developmental competence of bovine oocytes isolated from antral follicles of different sizes was assessed in three European laboratories (Belgium, UCL; Denmark, DIAS; France, INRA). Using the same protocol for in vitro production of embryos, the oocytes isolated from follicles with a diameter...

  14. Effect of dopamine on bethanechol-stimulated gastric antral motility in dogs with gastric fistula

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P

    1982-01-01

    The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula, using intraluminal strain-gauge transducers. Infusion of bethanechol increased the motility with regard to both frequency and strength. Dopamine, an endogenous...

  15. Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

    Science.gov (United States)

    Malik, G. M.; Bhat, M. Youssuf; rather, Ab. Rashid; Basu, Javaid Ahmad; Qureshi, Khursheed Ahmad

    1998-01-01

    Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis. Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis). Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005). PMID:18493464

  16. Association of mast cells with helicobacter pylori infection in the antral mucosa

    Directory of Open Access Journals (Sweden)

    SR KC

    2011-03-01

    Full Text Available Background: Helicobacter pylori infection is associated with mixed inflammatory cell infiltrate consisting of neutrophils, eosinophils, lymphocytes and plasma cells. Helicobacter pylori lead to mast cell degranulation and release of active chemical compounds in in-vitro conditions. The objective of this study was to find out the association of mast cell density and Helicobacter pylori in the antral mucosa of the stomach. Materials and Methods: A total of 150 endoscopic biopsies were included in the study. In addition to routine Hematoxylin and Eosin stained slides, Giemsa stain was done in each case for the evaluation of Helicobacter pylori and mast cell density in the gastric mucosa. Results: Out of 150 gastric biopsies with histopathological diagnosis of chronic gastritis, 36 cases (24% were positive for Helicobacter pylori. In the antral mucosa, mast cell density was significantly higher in the Helicobacter pylori-positive group than in the Helicobacter pylori-negative group (P<0.01. Conclusion: Mast cells may play a role in the development of Helicobacter pylori gastritis. Keywords: Gastritis; Mast Cell; Helicobacter pylori DOI: 10.3126/jpn.v1i1.4448 Journal of Pathology of Nepal (2011 Vol.1, 34-36

  17. Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.

    Directory of Open Access Journals (Sweden)

    Milena Saqui-Salces

    Full Text Available Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻ mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and eventually antral tumors. Since Hedgehog (Hh signaling is active in gastric cancers but its role in precursor lesions is poorly understood, we examined the role of inflammation and Hh signaling in antral hyperplasia. LacZ reporter mice for Sonic hedgehog (Shh, Gli1, and Gli2 expression bred onto the Gast⁻/⁻ background revealed reduced Shh and Gli1 expression in the antra compared to wild type controls (WT. Gli2 expression in the Gast⁻/⁻ corpus was unchanged. However in the hyperplastic Gast⁻/⁻ antra, Gli2 expression increased in both the mesenchyme and epithelium, whereas expression in WT mice remained exclusively mesenchymal. These observations suggested that Gli2 is differentially regulated in the hyperplastic Gast⁻/⁻ antrum versus the corpus and by a Shh ligand-independent mechanism. Moreover, the proinflammatory cytokines Il-1β and Il-11, which promote gastric epithelial proliferation, were increased in the Gast⁻/⁻ stomach along with Infγ. To test if inflammation could account for elevated epithelial Gli2 expression in the Gast⁻/⁻ antra, the human gastric cell line AGS was treated with IL-1β and was found to increase GLI2 but decrease GLI1 levels. IL-1β also repressed human GAST gene expression. Indeed, GLI2 but not GLI1 or GLI3 expression repressed gastrin luciferase reporter activity by ∼50 percent. Moreover, chromatin immunoprecipitation of GLI2 in AGS cells confirmed that GLI2 directly binds to the GAST promoter. Using a mouse model of constitutively active epithelial GLI2 expression, we found that activated GLI2 repressed Gast expression but induced Il-1β gene expression and proliferation in the gastric antrum, along with a reduction of the number of G-cells. In summary

  18. Antral hyperplastic polyp: A rare cause of gastric outlet obstruction.

    Science.gov (United States)

    Aydin, Ibrahim; Ozer, Ender; Rakici, Halil; Sehitoglu, Ibrahim; Yucel, Ahmet Fikret; Pergel, Ahmet; Sahin, Dursun Ali

    2014-01-01

    Gastric polyps are usually found incidentally during upper gastrointestinal endoscopic examinations. These polyps are generally benign, with hyperplasia being the most common. While gastric polyps are often asymptomatic, they can cause gastric outlet obstruction. A 64 years-old female patient presented to our polyclinic with a history of approximately 2 months of weakness, occasional early nausea, vomiting after meals and epigastric pain. A polypoid lesion of approximately 25mm in diameter was detected in the antral area of the stomach, which prolapsed through the pylorus into the duodenal bulbus, and subsequently caused gastric outlet obstruction, as revealed by upper gastrointestinal endoscopy of the patient. The polyp was retrieved from the pyloric canal into the stomach with the aid of a tripod, and snare polypectomy was performed. Currently, widespread use of endoscopy has led to an increase in the frequency of detecting hyperplastic polyps. While most gastric polyps are asymptomatic, they can cause iron deficiency anemia, acute pancreatitis and more commonly, gastric outlet obstruction because of their antral location. Although there are no precise principles in the treatment of asymptomatic polyps, polyps >5mm should be removed due to the possibility of malignant transformation. According to the medical evidence, polypectomy is required for gastric hyperplastic polyps because of the risks of complication and malignancy. These cases can be successfully treated endoscopically. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  19. Radiofrequency ablation for the treatment of gastric antral vascular ectasia

    DEFF Research Database (Denmark)

    Dray, X.; Repici, A.; Gonzalez, P.

    2014-01-01

    Background and study aims: The traditional endoscopic treatment for gastric antral vascular ectasia (GAVE) is argon plasma coagulation, but results are not always positive. Radiofrequency ablation (RFA) is a new endoscopic therapy that may be an attractive option for the treatment of GAVE. The aim...... of this study was to assess the efficacy and safety of RFA for the treatment of GAVE. Patients and methods: This was an open-label, retrospective, case series study. The main outcome measures were number of red blood cell (RBC) packs transfused (transfusion requirement) and hemoglobin concentrations (g...

  20. Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro

    International Nuclear Information System (INIS)

    Basavarajappa, Mallikarjuna S.; Craig, Zelieann R.; Hernandez-Ochoa, Isabel; Paulose, Tessie; Leslie, Traci C.; Flaws, Jodi A.

    2011-01-01

    The organochlorine pesticide methoxychlor (MXC) is a known endocrine disruptor that affects adult rodent females by causing reduced fertility, persistent estrus, and ovarian atrophy. Since MXC is also known to target antral follicles, the major producer of sex steroids in the ovary, the present study was designed to test the hypothesis that MXC decreases estradiol (E 2 ) levels by altering steroidogenic and metabolic enzymes in the antral follicles. To test this hypothesis, antral follicles were isolated from CD-1 mouse ovaries and cultured with either dimethylsulfoxide (DMSO) or MXC. Follicle growth was measured every 24 h for 96 h. In addition, sex steroid hormone levels were measured using enzyme-linked immunosorbent assays (ELISA) and mRNA expression levels of steroidogenic enzymes as well as the E 2 metabolic enzyme Cyp1b1 were measured using qPCR. The results indicate that MXC decreased E 2 , testosterone, androstenedione, and progesterone (P 4 ) levels compared to DMSO. In addition, MXC decreased expression of aromatase (Cyp19a1), 17β-hydroxysteroid dehydrogenase 1 (Hsd17b1), 17α-hydroxylase/17,20-lyase (Cyp17a1), 3β hydroxysteroid dehydrogenase 1 (Hsd3b1), cholesterol side-chain cleavage (Cyp11a1), steroid acute regulatory protein (Star), and increased expression of Cyp1b1 enzyme levels. Thus, these data suggest that MXC decreases steroidogenic enzyme levels, increases metabolic enzyme expression and this in turn leads to decreased sex steroid hormone levels. - Highlights: → MXC inhibits steroidogenesis → MXC inhibits steroidogenic enzymes → MXC induces metabolic enzymes

  1. Gastric antral vascular ectasia--a cause of refractory anaemia in systemic sclerosis.

    LENUS (Irish Health Repository)

    Busteed, S

    2012-02-03

    Recurrent gastrointestinal haemorrhage is an uncommon manifestation of systemic sclerosis. We report a case of gastrointestinal bleeding due to gastric antral vascular ectasia (GAVE) in a patient with systemic sclerosis. Failure to recognise the condition as a cause of gastrointestinal bleeding may delay the instigation of appropriate treatment. GAVE should be considered in the differential diagnosis of anaemia in patients with autoimmune conditions such as systemic sclerosis and primary biliary cirrhosis.

  2. Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy

    OpenAIRE

    Ohira, Tetsuya; Hokama, Akira; Kinjo, Nagisa; Nakamoto, Manabu; Kobashigawa, Chiharu; Kise, Yuya; Yamashiro, Satoshi; Kinjo, Fukunori; Kuniyoshi, Yukio; Fujita, Jiro

    2013-01-01

    Gastric antral vascular ectasia (GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal bleeding. The diagnosis is typically made based on the characteristic endoscopic features, including longitudinal row of flat, reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a watermelon. These appearances, however, can easily be misinterpreted as moderate to severe gastritis. Although it is believed that capsule endoscopy (C...

  3. Concentrations of AMH and inhibin-B in relation to follicular diameter in normal human small antral follicles

    DEFF Research Database (Denmark)

    Andersen, Claus Yding; Schmidt, Kirsten Tryde; Kristensen, Stine Gry

    2010-01-01

    The aim of the present study was to determine the intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-B and steroids in normal human small antral follicles and to relate them to follicular size....

  4. PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis.

    Science.gov (United States)

    Tanaka, Saori; Hosogi, Shigekuni; Sawabe, Yukinori; Shimamoto, Chikao; Matsumura, Hitoshi; Inui, Toshio; Marunaka, Yoshinori; Nakahari, Takashi

    2016-01-01

    A PPARα (peroxisome proliferation activation receptor α) agonist (GW7647) activates nitric oxide synthase 1 (NOS1) to produce NO leading to cGMP accumulation in antral mucous cells. In this study, we examined how PPARα activates NOS1. The NO production stimulated by GW7647 was suppressed by inhibitors of PI3K (wortmannin) and Akt (AKT 1/2 Kinase Inhibitor, AKT-inh), although it was also suppressed by the inhibitors of PPARα (GW6471) and NOS1 (N-PLA). GW7647 enhanced the ACh (acetylcholine)-stimulated exocytosis (Ca(2+)-regulated exocytosis) mediated via NO, which was abolished by GW6471, N-PLA, wortmannin, and AKT-inh. The Western blotting revealed that GW7647 phosphorylates NOS1 via phosphorylation of PI3K/Akt in antral mucous cells. The immunofluorescence examinations demonstrated that PPARα existing with NOS1 co-localizes with PI3K and Akt in the cytoplasm of antral mucous cells. ACh alone and AACOCF3, an analogue of arachidonic acid (AA), induced the NOS1 phosphorylation via PI3K/Akt to produce NO, which was inhibited by GW6471. Since AA is a natural ligand for PPARα, ACh stimulates PPARα probably via AA. In conclusion, PPARα activates NOS1 via PI3K/Akt phosphorylation to produce NO in antral mucous cells during ACh stimulation.

  5. Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1

    DEFF Research Database (Denmark)

    Nagell, C F; Wettergren, A; Pedersen, J F

    2004-01-01

    with GLP-1 inhibits gastric emptying and the sensation of hunger in man. METHODS: Eight healthy volunteers were tested in a double-blind, placebo-controlled fashion. Antral emptying of a liquid meal and hunger ratings were determined using ultrasound technology and visual analogue scales scoring during...... infusions of saline, GLP-2 (0.5, and 1.0 pmol kg body wt(-1) min(-1)), GLP-1 (0.5 pmol kg body wt(-1) min(-1)) or GLP-1 and GLP-2 (0.5 pmol kg body wt(-1) min(-1)). RESULTS: The GLP-2 infusions resulted in a dose-dependent increase in antral emptying time (35%; ns and 75%; P = 0.049) compared to saline...

  6. Left-right differences in ovarian volume and antral follicle count in 1423 women of reproductive age

    DEFF Research Database (Denmark)

    Korsholm, Anne-Sofie; Hvidman, Helene Westring; Bentzen, Janne Gasseholm

    2017-01-01

    The aim of this cross-sectional study was to investigate side differences in antral follicle count (AFC) and ovarian volume in left versus right ovaries in relation to chronological and "biological" age, the latter estimated by anti-Müllerian hormone (AMH) levels. The cohort comprised 1423 women...... ≤ 0.003). AFC was significantly higher in the right compared to the left ovary in the three upper AMH quartiles (p ≤ 0.005). The findings were similar when stratified in age quartiles. More than half (54.8%) had polycystic ovarian (PCO) morphology in at least one ovary. Of these women, 46.3% (n = 361......: 1014 fertile and 409 infertile. All were examined by transvaginal sonography and serum AMH. Overall the right ovary contained 8.1% more antral follicles (p = 0.002) and had 10.7% larger volume compared with the left (p right ovarian volume was larger than the left (p...

  7. Comparison of total and compartmental gastric emptying and antral motility between healthy men and women

    Energy Technology Data Exchange (ETDEWEB)

    Bennink, R.; Van den Maegdenbergh, V.; Roo, M. de; Mortelmans, L. [Department of Nuclear Medicine, UZ KU Leuven (Belgium); Peeters, M.; Geypens, B.; Rutgeerts, P. [Department of Gastroenterology, UZ KU Leuven (Belgium)

    1998-09-01

    There is increasing evidence of gender-related differences in gastric emptying. The purpose of this study was first, to confirm the difference in gastric emptying for both solid and liquid test meals between healthy men and women, and secondly, to investigate the origin of this difference by studying regional gastric emptying and antral motility. A standard gastric emptying test with additional compartmental (proximal and distal) evaluation and dynamic imaging of the antrum was performed in 20 healthy women studied during the first 10 days of the menstrual cycle, and in 31 healthy age-matched men. In concordance with previous reports, women had a longer half-emptying time for solids as compared to men (86.2{+-}5.1 vs 52.2{+-}2.9 min, P<0.05). In our observations this seemed to be related to a significantly prolonged lag phase and a significant decrease in terminal slope. Dynamical antral scintigraphy did not show a significant difference. The distribution of the test meal within the stomach (proximal vs distal) showed more early proximal retention in women as compared to men. The terminal slope of the distal somach was significantly lower in women. We did not observe a significant difference in gastric emptying of the liquid test meal between men and women. Gastric emptying of solids is significantly slower in healthy women as compared to men. These findings emphasise the importance of using different normal values for clinical and research purposes in gastric emptying scintigraphy in men and women. The difference could not be explained by antral motility alone. Increased proximal retention and a lower terminal emptying rate in women are observations to be further investigated. (orig.) With 5 figs., 2 tabs., 36 refs.

  8. Transcriptome profiling of the theca interna in transition from small to large antral ovarian follicles.

    Directory of Open Access Journals (Sweden)

    Nicholas Hatzirodos

    Full Text Available The theca interna layer of the ovarian follicle forms during the antral stage of follicle development and lies adjacent to and directly outside the follicular basal lamina. It supplies androgens and communicates with the granulosa cells and the oocyte by extracellular signaling. To better understand developmental changes in the theca interna, we undertook transcriptome profiling of the theca interna from small (3-5 mm, n = 10 and large (9-12 mm, n = 5 healthy antral bovine follicles, representing a calculated >7-fold increase in the amount of thecal tissue. Principal Component Analysis and hierarchical classification of the signal intensity plots for the arrays showed no clustering of the theca interna samples into groups depending on follicle size or subcategories of small follicles. From the over 23,000 probe sets analysed, only 76 were differentially expressed between large and small healthy follicles. Some of the differentially expressed genes were associated with processes such as myoblast differentiation, protein ubiquitination, nitric oxide and transforming growth factor β signaling. The most significant pathway affected from our analyses was found to be Wnt signaling, which was suppressed in large follicles via down-regulation of WNT2B and up-regulation of the inhibitor FRZB. These changes in the transcriptional profile could have been due to changes in cellular function or alternatively since the theca interna is composed of a number of different cell types it could have been due to any systematic change in the volume density of any particular cell type. However, our study suggests that the transcriptional profile of the theca interna is relatively stable during antral follicle development unlike that of granulosa cells observed previously. Thus both the cellular composition and cellular behavior of the theca interna and its contribution to follicular development appear to be relatively constant throughout the follicle growth

  9. Gastric antral vascular ectasia causing severe anemia.

    Science.gov (United States)

    Toyota, M; Hinoda, Y; Nakagawa, N; Arimura, Y; Tokuchi, S; Takaoka, A; Kitagawa, S; Usuki, T; Yabana, T; Yachi, A; Imai, K

    1996-10-01

    Gastric antral vascular ectasia (GAVE) that caused continuous gastrointestinal bleeding is reported in a 76-year-old woman who had been treated with repeated blood transfusions because of severe anemia. Endoscopic examination was performed and diffuse speckled telangiectasia of the entire antrum was observed. Laboratory data showed SGOT > SGPT, decreased chE level and the increased levels of serum gastrin and ICG at 15 min. Anti-HCV antibody was positive. Image examination revealed splenomegaly. There was no family history of telangiectasia, and no telangiectasia was found in other organs. The diagnosis was established as GAVE with liver cirrhosis. Surgical resection of the distal stomach resulted in termination of the bleeding, and the cirrhotic changes of the surface of the liver were revealed at that time, providing further evidence of liver cirrhosis. Although the pathogenesis of GAVE is unknown, liver cirrhosis and hypergastrinemia are thought to be associated with the condition. Importantly, this condition is a cause of severe gastrointestinal bleeding in elderly patients.

  10. PPARα autocrine regulation of Ca²⁺-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation.

    Science.gov (United States)

    Tanaka, Saori; Sugiyama, Nanae; Takahashi, Yuko; Mantoku, Daiki; Sawabe, Yukinori; Kuwabara, Hiroko; Nakano, Takashi; Shimamoto, Chikao; Matsumura, Hitoshi; Marunaka, Yoshinori; Nakahari, Takashi

    2014-12-15

    In antral mucous cells, acetylcholine (ACh, 1 μM) activates Ca(2+)-regulated exocytosis, consisting of a peak in exocytotic events that declines rapidly (initial phase) followed by a second slower decline (late phase) lasting during ACh stimulation. GW7647 [a peroxisome proliferation activation receptor α (PPARα) agonist] enhanced the ACh-stimulated initial phase, and GW6471 (a PPARα antagonist) abolished the GW7647-induced enhancement. However, GW6471 produced the delayed, but transient, increase in the ACh-stimulated late phase, and it also decreased the initial phase and produced the delayed increase in the late phase during stimulation with ACh alone. A similar delayed increase in the ACh-stimulated late phase is induced by an inhibitor of the PKG, Rp8BrPETcGMPS, suggesting that GW6471 inhibits cGMP accumulation. An inhibitor of nitric oxide synthase 1 (NOS1), N(5)-[imino(propylamino)methyl]-L-ornithine hydrochloride (N-PLA), also abolished the GW7647-induced-enhancement of ACh-stimulated initial phase but produced the delayed increase in the late phase. However, in the presence of N-PLA, an NO donor or 8BrcGMP enhanced the ACh-stimulated initial phase and abolished the delayed increase in the late phase. Moreover, GW7647 and ACh stimulated NO production and cGMP accumulation in antral mucosae, which was inhibited by GW6471 or N-PLA. Western blotting and immunohistochemistry revealed that NOS1 and PPARα colocalize in antral mucous cells. In conclusion, during ACh stimulation, a PPARα autocrine mechanism, which accumulates NO via NOS1 leading to cGMP accumulation, modulates the Ca(2+)-regulated exocytosis in antral mucous cells. Copyright © 2014 the American Physiological Society.

  11. Diagnosis and staging of carcinoma localized in the antral part of the stomach with spiral CT

    International Nuclear Information System (INIS)

    Pomakov, P.; Grudeva, V.; Mlachkova, D.

    2009-01-01

    The aim of the study was to characterize CT images and stages of carcinomas localized in the antral part of the stomach obtained with spiral CT. Seven men aged from 54 years old to 81 years old inclusive, with subjective complaints and clinical suspicion of a neoplasm in the upper gastrointestinal tract were examine Examinations were performed following stomach wall re relaxation with Buscolysin.The stomach is distended by drinking 600 ml of water. Upper abdomen scans were performed with spiral CT/e General Electric with the following parameters: slice thickness 3-5 mm, spacing 3 mm, pitch 1,5, reconstruction index 3 mm. After the pre-contrast scans, 100 ml of non-ionic contrast media is administered intravenously with an injection rate of 30 ml/sec. Scan delay time - 30 seconds after start of injection. Exposition data-120 kV, 180 mAs. Carcinoma localized in the antral part of the stomach was demonstrated in 7 patients. The staging showed: I stage - one patient, II stage - 2, III stage - 1 and IV stage - three patients. According to the macro morphological characteristic: exophytic type - 4, endophytic tumor - 1, ulcerous tumor - 1 and early carcinoma - 1 patient. In our material only male patients were present. Early carcinoma was demonstrated in a male patient at an age of 80 years old. An enhancing nodular local thickness was visualized. Differential diagnosis between malignant and benign ulcer is necessary in certain cases. It is performed on the contrast scans, the malignant process enhances twice its density, When performing a purposive CT examination it is possible to diagnose neoplasms in the antral part of the stomach, from stage i to IV with different macro morphologic characteristic

  12. The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count

    NARCIS (Netherlands)

    Broer, Simone L.; Mol, Ben Willem J.; Hendriks, Dave; Broekmans, Frank J. M.

    2009-01-01

    Objective: To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after lVF and to compare it with the performance of the antral follicle count (AFC). Design: A systematic review of existing literature and a meta-analysis were carried

  13. Comparison between manual and automated techniques for assessment of data from dynamic antral scintigraphy

    International Nuclear Information System (INIS)

    Misiara, Gustavo P.; Troncon, Luiz E.A.; Secaf, Marie; Moraes, Eder R.

    2008-01-01

    This work aimed at determining whether data from dynamic antral scintigraphy (DAS) yielded by a simple, manual technique are as accurate as those generated by a conventional automated technique (fast Fourier transform) for assessing gastric contractility. Seventy-one stretches (4 min) of 'activity versus time' curves obtained by DAS from 10 healthy volunteers and 11 functional dyspepsia patients, after ingesting a liquid meal (320 ml, 437 kcal) labeled with technetium-99m ( 99m Tc)-phytate, were independently analyzed by manual and automated techniques. Data obtained by both techniques for the frequency of antral contractions were similar. Contraction amplitude determined by the manual technique was significantly higher than that estimated by the automated method, in both patients and controls. The contraction frequency 30 min post-meal was significantly lower in patients than in controls, which was correctly shown by both techniques. A manual technique using ordinary resources of the gamma camera workstation, despite yielding higher figures for the amplitude of gastric contractions, is as accurate as the conventional automated technique of DAS analysis. These findings may favor a more intensive use of DAS coupled to gastric emptying studies, which would provide a more comprehensive assessment of gastric motor function in disease. (author)

  14. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

    International Nuclear Information System (INIS)

    Peretz, Jackye; Flaws, Jodi A.

    2013-01-01

    Bisphenol A (BPA) is the backbone of polycarbonate plastic products and the epoxy resin lining of aluminum cans. Previous studies have shown that exposure to BPA decreases sex steroid hormone production in mouse antral follicles. The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex steroid hormone production in vitro. Further, the current study tests the hypothesis that these effects are acute and reversible after removal of BPA. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased expression of Cyp11a1 and StAR beginning at 18 h and 72 h, respectively, compared to controls. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased progesterone levels beginning at 24 h and decreased androstenedione, testosterone, and estradiol levels at 72 h and 96 h compared to controls. Further, after removing BPA from the culture media at 20 h, expression of Cyp11a1 and progesterone levels were restored to control levels by 48 h and 72 h, respectively. Additionally, expression of StAR and levels of androstenedione, testosterone, and estradiol never decreased compared to controls. These data suggest that BPA acutely decreases expression of Cyp11a1 as early as 18 h and this reduction in Cyp11a1 may lead to a decrease in progesterone production by 24 h, followed by a decrease in androstenedione, testosterone, and estradiol production and expression of StAR at 72 h. Therefore, BPA exposure likely targets Cyp11a1 and steroidogenesis, but these effects are reversible with removal of BPA exposure. - Highlights: • BPA may target Cyp11a1 to inhibit steroidogenesis in antral follicles. • BPA may decrease the expression of Cyp11a1 prior to inhibiting steroidogenesis. • The adverse effects of BPA on steroidogenesis in antral follicles are reversible

  15. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

    Energy Technology Data Exchange (ETDEWEB)

    Peretz, Jackye, E-mail: peretz@illinois.edu [2001 South Lincoln Ave, 3211 VMBSB, University of Illinois, Urbana, IL 61802 (United States); Flaws, Jodi A., E-mail: jflaws@illinois.edu [2001 South Lincoln Ave, 3223 VMBSB, University of Illinois, Urbana, IL 61802 (United States)

    2013-09-01

    Bisphenol A (BPA) is the backbone of polycarbonate plastic products and the epoxy resin lining of aluminum cans. Previous studies have shown that exposure to BPA decreases sex steroid hormone production in mouse antral follicles. The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex steroid hormone production in vitro. Further, the current study tests the hypothesis that these effects are acute and reversible after removal of BPA. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased expression of Cyp11a1 and StAR beginning at 18 h and 72 h, respectively, compared to controls. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased progesterone levels beginning at 24 h and decreased androstenedione, testosterone, and estradiol levels at 72 h and 96 h compared to controls. Further, after removing BPA from the culture media at 20 h, expression of Cyp11a1 and progesterone levels were restored to control levels by 48 h and 72 h, respectively. Additionally, expression of StAR and levels of androstenedione, testosterone, and estradiol never decreased compared to controls. These data suggest that BPA acutely decreases expression of Cyp11a1 as early as 18 h and this reduction in Cyp11a1 may lead to a decrease in progesterone production by 24 h, followed by a decrease in androstenedione, testosterone, and estradiol production and expression of StAR at 72 h. Therefore, BPA exposure likely targets Cyp11a1 and steroidogenesis, but these effects are reversible with removal of BPA exposure. - Highlights: • BPA may target Cyp11a1 to inhibit steroidogenesis in antral follicles. • BPA may decrease the expression of Cyp11a1 prior to inhibiting steroidogenesis. • The adverse effects of BPA on steroidogenesis in antral follicles are reversible.

  16. Composite three-layer closure of oral antral communication with 10 months follow-up-a case study.

    Science.gov (United States)

    Weinstock, Robert J; Nikoyan, Levon; Dym, Harry

    2014-02-01

    We propose a 3-layer composite closure technique for an oral antral communication (OAC) while avoiding secondary donor site morbidity. A patient had developed a 1-cm OAC after extraction of right maxillary first molar. The patient subsequently developed acute maxillary sinusitis. The patient was taken to the operating room, and a Caldwell-Luc procedure was performed. The bony window from the Caldwell-Luc was "press fit" over the bony OAC defect. Soft tissue closure was then achieved with a buccal fat pad flap and a buccal mucosal advancement flap. The patient was examined on postoperative day 5 and 1, 2, 3, 6, and 10 months postoperatively. The acute sinusitis had resolved. The soft tissue closure was successful. The bone graft remained intact, prevented sinus pneumatization, and restored continuity to the floor of the maxillary sinus. The presented technique for 3-layer closure of OACs allows for the stability of a double-layer closure of OAC with the added benefit of bone grafting from single operative site, achieving stable oral antral closure, bone grafting, and the avoidance of secondary donor site morbidity. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  17. Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles.

    Science.gov (United States)

    Veiga-Lopez, Almudena; Ye, Wen; Padmanabhan, Vasantha

    2012-03-01

    To investigate the impact of prenatal T excess on the expression of key ovarian regulators implicated in follicular recruitment and persistence using a large animal model of polycystic ovarian syndrome (PCOS). Interventional, animal model study. Academic research unit. A total of 25 female fetuses, 14 prepubertal female, and 24 adult female Suffolk sheep. Prenatal T treatment. Immunohistochemical determination of expression of anti-Müllerian hormone (AMH), kit ligand, and growth differentiation factor 9 (GDF9) in fetal, prepubertal, and adult ovarian tissues. Prenatal T treatment reduced the AMH protein expression in granulosa cells (GC) of preantral follicles and increased its expression in antral follicles compared with age-matched adult controls. These differences were not evident in prepubertal animals. Protein expression of GDF9 and kit ligand was not altered at any of the developmental time points studied. Prenatal T exposure is associated with changes in AMH expression in preantral and antral follicles in adult ovaries, similar to findings in women with PCOS. These findings indicate that abnormal folliculogenesis in PCOS may be at least in part mediated by changes in AMH expression. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  18. The association of protein intake (amount and type) with ovarian antral follicle counts among infertile women: results from the EARTH prospective study cohort.

    Science.gov (United States)

    Souter, I; Chiu, Y-H; Batsis, M; Afeiche, M C; Williams, P L; Hauser, R; Chavarro, J E

    2017-09-01

    To evaluate the association between protein intake (amount and type) and antral follicle count (AFC). Prospective cohort. Academic fertility centre. Two hundred and sixty-five women undergoing fertility treatments at an academic fertility centre and participating in an ongoing study on environment and reproductive health. We measured AFC in ultrasonographic evaluation among women undergoing infertility treatments. Women completed a previously validated semi-quantitative food frequency questionnaire. We used Poisson regression to evaluate the relation between protein intake and AFC while adjusting for age, body mass index, race, smoking status, and total energy intake. Antral follicle count. Among 265 women (mean age: 35.0 ± 3.9 years, 85% Caucasian), total protein intake (% energy) was unrelated to AFC. When protein from different food sources was considered separately, we found a negative association between dairy protein intake and AFC. The mean AFC was 14.4% (3.9-23.7%) lower for women in the highest quintile of dairy protein intake than for women in the bottom quintile after adjusting for potential confounders (P-trend = 0.04). This association was stronger among women who had never smoked (P-trend = 0.002) but was not observed among previous smokers (P-trend = 0.36). There were no associations between protein intake from either non-dairy animal or vegetable sources and AFC. Higher dairy protein intake (≥5.24% of energy) was associated with lower antral follicle counts among women presenting for infertility treatment. These findings should be further investigated in prospective studies also designed to clarify the biology underlying the observed associations. Higher dairy protein intake was associated with lower antral follicle counts in an infertile population. © 2017 Royal College of Obstetricians and Gynaecologists.

  19. Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

    OpenAIRE

    Gh. Jeelani Romshoo; G. M. Malik; M. Youssuf Bhat; Ab. Rashid rather; Javaid Ahmad Basu; Khursheed Ahmad Qureshi

    1998-01-01

    Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric...

  20. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    International Nuclear Information System (INIS)

    Craig, Zelieann R.; Hannon, Patrick R.; Flaws, Jodi A.

    2013-01-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P 4 ) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P 4 , androstenedione (A), testosterone (T), estrone (E 1 ), and 17β-estradiol (E 2 ) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E 2 . Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P 4 , A, T, and E 1 that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis in mono-OH MXC

  1. Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

    Energy Technology Data Exchange (ETDEWEB)

    Craig, Zelieann R., E-mail: zelieann@illinois.edu; Hannon, Patrick R., E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

    2013-11-01

    Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P{sub 4}) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P{sub 4}, androstenedione (A), testosterone (T), estrone (E{sub 1}), and 17β-estradiol (E{sub 2}) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E{sub 2}. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P{sub 4}, A, T, and E{sub 1} that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis

  2. In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA

    DEFF Research Database (Denmark)

    Nielsen, M. E.; Rasmussen, I. A.; Kristensen, S. G.

    2011-01-01

    significantly with the expression of AMHRII, but did not correlate with any of the hormones in the follicular fluid. These data demonstrate an intimate association between AR expression in immature granulosa cells, and the expression of FSHR in normal small human antral follicles and between the follicular......Human small antral follicles (diameter 3-9 mm) were obtained from ovaries surgically removed for fertility preservation. From the individual aspirated follicles, granulosa cells and the corresponding follicular fluid were isolated in 64 follicles, of which 55 were available for mRNA analysis (24...... and to the follicular fluid concentrations of AMH, inhibin-B, progesterone and estradiol. AR mRNA expression in granulosa cells and the follicular fluid content of androgens both showed a highly significant positive association with the expression of FSHR mRNA in granulosa cells. AR mRNA expression also correlated...

  3. Sodium pertechnetate Tc 99m antral scan in the diagnosis of retained gastric antrum

    International Nuclear Information System (INIS)

    Lee, C.H.; P'eng, F.K.; Yeh, P.H.

    1984-01-01

    Retained gastric antrum (RGA) is a major factor in recurrent peptic ulcer. We studied 121 patients with proven anastomotic ulcers following subtotal gastrectomy and Billroth II reconstruction with sodium pertechnetate Tc 99m to determine the presence of RGA. Of the patients, 59 required surgery, 22 had RGA, and 16 had a positive scan for RGA. This noninvasive examination has 100% specificity. If RGA is identified before operation, minimal time is wasted in exploration of the abdomen, which is especially important in dealing with emergency cases. When an antral scan is negative for RGA, the surgeon is still advised to search for this condition

  4. The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR -29G > A Affects Androgen Production in Normal Human Small Antral Follicles

    DEFF Research Database (Denmark)

    Borgbo, Tanni; Klučková, Hana; Macek, Milan

    2017-01-01

    ) FSHR -29G > A (rs1394205) on hormonal conditions in humsan small antral follicles (hSAFs) obtained from women in the natural menstrual cycle. This study investigated the follicle fluid (FF) concentrations of anti-Müllerian hormone, estradiol, progesterone, androstenedione, and testosterone in h...

  5. Comparison of anti-mullerian hormone and antral follicle count for assessment of ovarian reserve

    Directory of Open Access Journals (Sweden)

    Sonal Panchal

    2012-01-01

    Full Text Available Aim: This study aims to compare the efficacy of AFC and AMH, as markers for ovarian reserve. Materials and Methods: 75 patients with PCO (polycystic ovaries undergoing IVF were randomized with 75 non-PCO patients. On day 3, volume of ovary was acquired, ovarian volume was defined by VOCAL, and Sono AVC was used to count the number of antral follicles. Sum total of antral follicles in both ovaries was taken as total antral follicle count (AFC. AMH was measured on the same day. Long agonist protocol with recombinant FSH (rFSH was used for IVF stimulation till at least two follicles of 18 mm were seen. hCG 10,000 iu was given and ovum pick up was done after 34-35 h. Primary end point was number of follicles >12 mm seen on day of hCG. Final end point was number of ova retrieved on ovum pick up. Correlation of AFC and AMH was checked for both end points and with each other. Results: Correlation of AFC and follicles >12 mm on day of hCG in PCO group is 0.56 and non-PCO group is 0.63, 1 and for AMH and follicles >12 mm on day of hCG in PCO group is 0.42 and non-PCO group is 0.47. Correlation of AFC with number of ova retrieved on OPU in PCO group is 0.44 and for non-PCO group is 0.50. The value for AMH is 0.39 in PCO and 0.43 for non-PCO group. Comparing correlation of AFC and AMH for primary end point in PCO group has ′z′ value 1.11(onetailed significance 0.1335, twotailed significance 0.267 and in non-PCO group comparison shows a ′z′ value of 1.39 (one tailed significance 0.0823, two-tailed significance 0.1645. Therefore in both groups, AFC and AMH correlates with total number of follicles >12 mm on day of hCG, but both AFC and AMH have independent significance. Comparing correlation of AFC and AMH with number of ova retrieved on OPU, in non-PCO group has ′z′ value of 0.54(one tailed 0.2946, two-tailed 0. 5892. In PCO group, this comparison shows, ′z′ value of 0.36(one tailed 0.3594, two tailed 0.7188. Conclusion: AFC and AMH

  6. Production of the first offspring from oocytes derived from fresh and cryopreserved pre-antral follicles of adult mice

    DEFF Research Database (Denmark)

    Kagawa, Norika; Kuwayama, Masashige; Nakata, Kumiko

    2007-01-01

    transplanted beneath the kidney capsule of severe combined immunodeficient (SCID) mice. Within 10 days of in-vivo culture, 138 full size oocytes developed from the 456 transplanted pre-antral follicles. In-vivo growth of follicles was followed by in-vitro oocyte maturation, in-vitro fertilization...... and subsequent embryo transfer, leading to the birth of 10 healthy pups. These results may lead to increasing the availability and cryopreservation possibilities for the preservation of fertility using ovarian tissue...

  7. Effect of sildenafil on gastric emptying and postprandial frequency of antral contractions in healthy humans

    DEFF Research Database (Denmark)

    Madsen, J L; Søndergaard, S B; Fuglsang, S

    2004-01-01

    BACKGROUND: Sildenafil is known to block phosphodiesterase type 5, which degrades nitric oxide-stimulated cyclic guanosine monophosphate, thereby relaxing smooth muscle cells in various organs. The effect of sildenafil on gastric motor function after a meal was investigated in healthy humans....... METHODS: Ten healthy male volunteers (21-28 years) participated in a placebo-controlled, double-blind, cross-over study. In random order and on two separate days each volunteer ingested either 50 mg sildenafil (Viagra, Pfizer, New York, N.Y., USA) or placebo. A gamma camera technique was used to measure......: A single dose of 50 mg sildenafil does not change gastric emptying or postprandial frequency of antral contractions in healthy volunteers....

  8. Antral atrophy, intestinal metaplasia, and pre-neoplastic markers in Mexican children with Helicobacter pylori-positive and negative gastritis

    Science.gov (United States)

    Villarreal-Calderon, Rodolfo; Luévano-González, Arturo; Aragón-Flores, Mariana; Zhu, Hongtu; Yuan, Ying; Xiang, Qun; Yan, Benjamin; Stoll, Kathryn Anne; Cross, Janet V.; Iczkowski, Kenneth A.; Mackinnon, Alexander Craig

    2015-01-01

    Chronic inflammation and infection are major risk factors for gastric carcinogenesis in adults. As chronic gastritis is common in Mexican children, diagnosis of Helicobacter pylori and other causes of gastritis are critical for the identification of children who would benefit from closer surveillance. Antral biopsies from 82 Mexican children (mean age 8.3±4.8y) with chronic gastritis (36 H. pylori +, 46 H. pylori -) were examined for gastritis activity, atrophy, intestinal metaplasia, and immunohistochemical expression of gastric carcinogenesis biomarkers CDX2, ephrin type-B receptor 4, matrix metalloproteinase 3 (MMP3), macrophage migration inhibitory factor (MIF), p53, β-catenin, and E-cadherin. Atrophy was diagnosed in 7/82 (9%) and intestinal metaplasia in 5/82 (6%) by routine histology, while 6 (7%) additional children (3 H. pylori +) exhibited aberrant CDX2 expression without intestinal metaplasia. Significant positive correlations were seen between EphB4, MMP3, and MIF (p<0.0001). Atrophy and follicular pathology were more frequent in H. pylori + biopsies (p<0.0001), while intestinal metaplasia and CDX2 expression showed no significant correlation with H. pylori status. Antral biopsies demonstrating atrophy, intestinal metaplasia, and/or aberrant CDX2 expression were seen in 21.95 % (18/82) of the children, potentially identifying those who would benefit from closer surveillance and preventive dietary strategies. Biomarkers CDX2, EphB4, MMP3, and MIF may be useful in the work-up of pediatric gastritis. PMID:24656654

  9. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization

    Directory of Open Access Journals (Sweden)

    Elting Mariet E

    2007-03-01

    Full Text Available Abstract Background The current study was designed to compare antral follicle count (AFC and basal ovarian volume (BOV, the exogenous FSH ovarian reserve test (EFORT and the clomiphene citrate challenge test (CCCT, with respect to their ability to predict poor and hyper responders. Methods One hundred and ten regularly menstruating patients, aged 18–39 years, participated in this prospective study, randomized, by a computer designed 4-blocks system study into two groups. Fifty six patients underwent a CCCT, and 54 patients underwent an EFORT. All patients underwent a transvaginal sonography to measure the basal ovarian volume and count of basal antral follicle. In all patients, the test was followed by a standard IVF treatment. The result of ovarian hyperstimulation during IVF treatment, expressed by the total number of follicles, was used as gold standard. Results The best prediction of ovarian reserve (Y was seen in a multiple regression prediction model that included, AFC, Inhibin B-increment in the EFORT and BOV simultaneously (Y = -3.161 + 0.805 × AFC (0.258-1.352 + 0.034 × Inh. B-incr. (0.007-0.601 + 0.511 BOV (0.480-0.974 (r = 0.848, p Conclusion In conclusion AFC performs well as a test for ovarian response being superior or at least similar to complex expensive and time consuming endocrine tests. It is therefore likely to be the test for general practise.

  10. Each small antral follicle in ovaries of women with polycystic ovary syndrome produces more antimüllerian hormone than its counterpart in a normal ovary: an observational cross-sectional study.

    Science.gov (United States)

    Bhide, Priya; Dilgil, Merve; Gudi, Anil; Shah, Amit; Akwaa, Charity; Homburg, Roy

    2015-02-01

    To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women. Observational cross-sectional study. Fertility clinic. A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013. Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria. The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control. The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status. Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  11. Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress

    International Nuclear Information System (INIS)

    Sobinoff, A.P.; Beckett, E.L.; Jarnicki, A.G.; Sutherland, J.M.; McCluskey, A.; Hansbro, P.M.; McLaughlin, E.A.

    2013-01-01

    Cigarette smoke is a reproductive hazard associated with pre-mature reproductive senescence and reduced clinical pregnancy rates in female smokers. Despite an increased awareness of the adverse effects of cigarette smoke exposure on systemic health, many women remain unaware of the adverse effects of cigarette smoke on female fertility. This issue is compounded by our limited understanding of the molecular mechanisms behind cigarette smoke induced infertility. In this study we used a direct nasal exposure mouse model of cigarette smoke-induced chronic obstructive pulmonary disease to characterise mechanisms of cigarette-smoke induced ovotoxicity. Cigarette smoke exposure caused increased levels of primordial follicle depletion, antral follicle oocyte apoptosis and oxidative stress in exposed ovaries, resulting in fewer follicles available for ovulation. Evidence of oxidative stress also persisted in ovulated oocytes which escaped destruction, with increased levels of mitochondrial ROS and lipid peroxidation resulting in reduced fertilisation potential. Microarray analysis of ovarian tissue correlated these insults with a complex mechanism of ovotoxicity involving genes associated with detoxification, inflammation, follicular activation, immune cell mediated apoptosis and membrane organisation. In particular, the phase I detoxifying enzyme cyp2e1 was found to be significantly up-regulated in developing oocytes; an enzyme known to cause molecular bioactivation resulting in oxidative stress. Our results provide a preliminary model of cigarette smoke induced sub-fertility through cyp2e1 bioactivation and oxidative stress, resulting in developing follicle depletion and oocyte dysfunction. - Highlights: • Cigarette smoke exposure targets developing follicle oocytes. • The antral follicle oocyte is a primary site of ovarian cigarette smoke metabolism. • Cyp2e1 is a major enzyme involved in ameliorating smoke-induced ovotoxicity. • Cigarette smoke causes oocyte

  12. Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Sobinoff, A.P. [Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308 (Australia); Priority Research Centre for Chemical Biology, University of Newcastle, Callaghan, NSW 2308 (Australia); Beckett, E.L.; Jarnicki, A.G. [Centre for Asthma and Respiratory Disease, The University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308 (Australia); Sutherland, J.M. [Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308 (Australia); Priority Research Centre for Chemical Biology, University of Newcastle, Callaghan, NSW 2308 (Australia); McCluskey, A. [Priority Research Centre for Chemical Biology, University of Newcastle, Callaghan, NSW 2308 (Australia); Hansbro, P.M. [Centre for Asthma and Respiratory Disease, The University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308 (Australia); McLaughlin, E.A., E-mail: eileen.mclaughlin@newcastle.edu.au [Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308 (Australia); Priority Research Centre for Chemical Biology, University of Newcastle, Callaghan, NSW 2308 (Australia)

    2013-09-01

    Cigarette smoke is a reproductive hazard associated with pre-mature reproductive senescence and reduced clinical pregnancy rates in female smokers. Despite an increased awareness of the adverse effects of cigarette smoke exposure on systemic health, many women remain unaware of the adverse effects of cigarette smoke on female fertility. This issue is compounded by our limited understanding of the molecular mechanisms behind cigarette smoke induced infertility. In this study we used a direct nasal exposure mouse model of cigarette smoke-induced chronic obstructive pulmonary disease to characterise mechanisms of cigarette-smoke induced ovotoxicity. Cigarette smoke exposure caused increased levels of primordial follicle depletion, antral follicle oocyte apoptosis and oxidative stress in exposed ovaries, resulting in fewer follicles available for ovulation. Evidence of oxidative stress also persisted in ovulated oocytes which escaped destruction, with increased levels of mitochondrial ROS and lipid peroxidation resulting in reduced fertilisation potential. Microarray analysis of ovarian tissue correlated these insults with a complex mechanism of ovotoxicity involving genes associated with detoxification, inflammation, follicular activation, immune cell mediated apoptosis and membrane organisation. In particular, the phase I detoxifying enzyme cyp2e1 was found to be significantly up-regulated in developing oocytes; an enzyme known to cause molecular bioactivation resulting in oxidative stress. Our results provide a preliminary model of cigarette smoke induced sub-fertility through cyp2e1 bioactivation and oxidative stress, resulting in developing follicle depletion and oocyte dysfunction. - Highlights: • Cigarette smoke exposure targets developing follicle oocytes. • The antral follicle oocyte is a primary site of ovarian cigarette smoke metabolism. • Cyp2e1 is a major enzyme involved in ameliorating smoke-induced ovotoxicity. • Cigarette smoke causes oocyte

  13. Anti-Müllerian hormone, follicle stimulating hormone, antral follicle count, and risk of menopause within 5 years.

    Science.gov (United States)

    Kim, Catherine; Slaughter, James C; Wang, Erica T; Appiah, Duke; Schreiner, Pamela; Leader, Benjamin; Calderon-Margalit, Ronit; Sternfeld, Barbara; Siscovick, David; Wellons, Melissa

    2017-08-01

    To evaluate the ability of concentration of anti-Müllerian hormone (AMH), antral follicle count (AFC), and concentration of follicle stimulating hormone (FSH) to predict the onset of menopause. The Coronary Artery Risk Development in Young Adults Study (CARDIA) Women's Study was an ancillary study to CARDIA, a population-based study of adults aged 18-30 years followed for 3 decades. For this report, participants were women (n=426) who had attended the CARDIA year 15-16 (2000-2001) examination, had at least one ovary, were not pregnant, and underwent serum AMH and FSH measurement and transvaginal ultrasonography in 2002-2003. The probability of menopause in 5 years based upon AMH, FSH, and AFC. The mean age of the women at the time of AMH, FSH, and AFC assessment was 43 years. The cumulative incidence of menopause at 25 years (or follow-up) was 27% (n=426), and the incidence within 5 years was 13% (n=55). Among women aged 45-49 years, undetectable AMH concentrations were associated with a greater than 60% probability of menopause within 5 years, whereas approximately 1/3 of women with no or just one antral follicle experienced menopause within 5 years. Both low and high concentrations of FSH were associated with greater odds of menopause than intermediate concentrations. Models with multiple markers did not improve the prediction of menopause over that afforded by models with single markers. The ability to predict onset of menopause was improved with any of the three menopausal markers in addition to age. AMH concentrations were more closely associated with menopause than AFC or FSH. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. [Gastric vascular lesions in cirrhosis: gastropathy and antral vascular ectasia].

    Science.gov (United States)

    Casas, Meritxell; Calvet, Xavier; Vergara, Mercedes; Bella, Maria Rosa; Junquera, Félix; Martinez-Bauer, Eva; Campo, Rafael

    2015-02-01

    Portal hypertensive gastropathy (GHP) is a complication of portal hypertension usually associated with liver cirrhosis. The pathogenesis is unclear but the presence of portal hypertension is an essential factor for its development. GHP may be asymptomatic or present as gastrointestinal bleeding or iron deficiency anemia. Endoscopic lesions vary from a mosaic pattern to diffuse red spots; the most common location is the fundus. Treatment is indicated when there is acute or chronic bleeding, as secondary prophylaxis. There is insufficient evidence to recommend primary prophylaxis in patients who have never bled. Drugs that decrease portal pressure, such as non-cardioselective beta-blockers, and/or endoscopic ablative treatments, such as argon-beam coagulation, may be used. The role of transarterial intrahepatic portosystemic shunt) or bypass surgery has been insufficiently analyzed. Antral vascular ectasia (EVA) is a rare entity in liver cirrhosis, whose pathophysiology is still unknown. Clinical presentation is similar to that of GHP and endoscopy usually shows red spots in the antrum. Biopsy is often required to differentiate EVA from GHP. There is no effective medical therapy, so endoscopic ablative therapy and, in severe cases, antrectomy are recommended. Copyright © 2014 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  15. A Case of Gastric Antral Vascular Ectasia Which Was Aggravated by Acid Reducer

    Directory of Open Access Journals (Sweden)

    Yukiomi Nakade

    2017-02-01

    Full Text Available Gastric antral vascular ectasia (GAVE is known to be characterized by red patches or spots in a diffuse or linear array in the antrum of the stomach. The precise etiology of GAVE remains to be elucidated. Argon plasma laser coagulation (APC has been used to control oozing from GAVE; however, there is no satisfactory long-term effect of APC in the control of oozing from GAVE. An acid reducer is used after APC because even physiological acid exposure might delay post-APC ulcer healing. We describe the case of a patient who had used an acid reducer and experienced repeated gastrointestinal hemorrhage due to GAVE. After ceasing to administer the acid reducer, incidences of hospitalization due to oozing from GAVE stopped. After the administration of the acid reducer was restarted, the patient had tarry stool, and diffuse oozing of blood was seen again. We report a first case of GAVE which was aggravated by acid reducer.

  16. Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy

    Science.gov (United States)

    Ohira, Tetsuya; Hokama, Akira; Kinjo, Nagisa; Nakamoto, Manabu; Kobashigawa, Chiharu; Kise, Yuya; Yamashiro, Satoshi; Kinjo, Fukunori; Kuniyoshi, Yukio; Fujita, Jiro

    2013-01-01

    Gastric antral vascular ectasia (GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal bleeding. The diagnosis is typically made based on the characteristic endoscopic features, including longitudinal row of flat, reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a watermelon. These appearances, however, can easily be misinterpreted as moderate to severe gastritis. Although it is believed that capsule endoscopy (CE) is not helpful for the study of the stomach with its large lumen, GAVE can be more likely to be detected at CE rather than conventional endoscopy. CE can be regarded as “physiologic” endoscopy, without the need for gastric inflation and subsequent compression of the vasculature. The blood flow of the ecstatic vessels may be diminished in an inflated stomach. Therefore, GAVE may be prominent in CE. We herein describe a case of active bleeding from GAVE detected by CE and would like to emphasize a possibility that CE can improve diagnostic yields for GAVE. PMID:23515703

  17. Survival and growth of isolated pre-antral follicles from human ovarian medulla tissue during long-term 3D culture

    DEFF Research Database (Denmark)

    Yin, H L; Kristensen, S G; Jiang, H

    2016-01-01

    during long-term culture has received only little attention. STUDY DESIGN, SIZE, DURATION: Two to ten human pre-antral follicles were encapsulated together within an alginate bead and cultured with or without ovarian interstitial tissue for either 7 days or >30 days. Follicles were cultured in either 20...... interregional project ReproHigh are thanked for having funded this study; and the Key Program of Medical Science and Technology Innovation of Nanjing Military Area Command in China (14ZX06; 11Z010). They had no role in the study design, collection and analysis of data, data interpretation or in writing...

  18. The Common Follicle-Stimulating Hormone Receptor (FSHR Promoter Polymorphism FSHR −29G > A Affects Androgen Production in Normal Human Small Antral Follicles

    Directory of Open Access Journals (Sweden)

    Tanni Borgbo

    2017-06-01

    Full Text Available Follicle-stimulating hormone receptors (FSHRs are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP FSHR −29G > A (rs1394205 on hormonal conditions in humsan small antral follicles (hSAFs obtained from women in the natural menstrual cycle. This study investigated the follicle fluid (FF concentrations of anti-Müllerian hormone, estradiol, progesterone, androstenedione, and testosterone in hSAF in relation to the different genotypes of FSHR −29G > A. FF from 362 follicles was collected in 95 women undergoing fertility preservation, who did not suffer from a disease that directly affected ovarian function. The testosterone levels of the minor A/A genotype were significantly increased compared to the A/G and the G/G genotype. Furthermore, significantly reduced androstenedione levels were observed for the G/G genotype, as compared to the A/G genotype, while the other hormones did not show statistical significant differences. In conclusion, the androgen levels of hSAF were significantly elevated in the minor SNP genotype in the FSHR promoter polymorphism FSHR −29G > A.

  19. The Distribution of Stroma and Antral Follicles Differs between Insulin-Resistance and Hyperandrogenism-Related Polycystic Ovarian Syndrome

    Directory of Open Access Journals (Sweden)

    Carlo Alviggi

    2017-05-01

    Full Text Available IntroductionAlthough insulin resistance plays an important pathogenetic role in polycystic ovary syndrome (PCOS, no correlation between ultrasound PCOS pattern and insulin resistance has yet been reported. The aim of this retrospective observational study was to assess whether the ovarian ultrasonographic parameter differed between PCOS women with insulin resistance and those with a hyperandrogenic profile.Materials and methodsWomen who fulfilled the Rotterdam criteria for PCOS were retrospectively studied. Anthropometric, biochemical, and clinical data were recorded. Women were divided into two groups based on specific transvaginal ultrasound parameters: subjects with more than half of the follicles measuring between 5 and 9 mm in diameter, an ultrasonographic determined stroma/total area (S/A > 0.34 and a “necklace” sign of antral follicles (Group A; and subjects with more than half of the antral follicles measuring between 2 and 4 mm in diameter, an S/A ≤ 0.34; no “necklace” sign but ubiquitously distributed follicles determined by ultrasound (Group B. The association between these ultrasound patterns and the presence of insulin resistance was also evaluated.ResultsSeventy-eight patients were enrolled: 33 with ultrasound sound pattern A and 45 with pattern B. The latter pattern had a sensitivity of 88% and a specificity of 78% in predicting PCOS women with insulin resistance. There were no differences in age, Ferriman–Gallwey score, and serum gonadotropin or androgen levels between the two groups. Body mass index, the waist-to-hip ratio, and homeostasis model assessment were significantly higher in group B than in group A (p < 0.05. Conversely, sex hormone binding globulin levels and ovarian volume were significantly higher in group A (p < 0.05. Insulin resistance was more frequent in group B than in group A (36/41, 87.8% versus 7/32, 21.8%; p < 0.05.ConclusionThese results suggest that insulin resistance

  20. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles.

    Science.gov (United States)

    Peretz, Jackye; Flaws, Jodi A

    2013-09-01

    Bisphenol A (BPA) is the backbone of polycarbonate plastic products and the epoxy resin lining of aluminum cans. Previous studies have shown that exposure to BPA decreases sex steroid hormone production in mouse antral follicles. The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex steroid hormone production in vitro. Further, the current study tests the hypothesis that these effects are acute and reversible after removal of BPA. Exposure to BPA (10μg/mL and 100μg/mL) significantly decreased expression of Cyp11a1 and StAR beginning at 18h and 72h, respectively, compared to controls. Exposure to BPA (10μg/mL and 100μg/mL) significantly decreased progesterone levels beginning at 24h and decreased androstenedione, testosterone, and estradiol levels at 72h and 96h compared to controls. Further, after removing BPA from the culture media at 20h, expression of Cyp11a1 and progesterone levels were restored to control levels by 48h and 72h, respectively. Additionally, expression of StAR and levels of androstenedione, testosterone, and estradiol never decreased compared to controls. These data suggest that BPA acutely decreases expression of Cyp11a1 as early as 18h and this reduction in Cyp11a1 may lead to a decrease in progesterone production by 24h, followed by a decrease in androstenedione, testosterone, and estradiol production and expression of StAR at 72h. Therefore, BPA exposure likely targets Cyp11a1 and steroidogenesis, but these effects are reversible with removal of BPA exposure. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Infertile women below the age of 40 have similar anti-Müllerian hormone levels and antral follicle count compared with women of the same age with no history of infertility

    DEFF Research Database (Denmark)

    Hvidman, H. W.; Bentzen, J. G.; Thuesen, L. L.

    2016-01-01

    STUDY QUESTION: Do infertile patients below the age of 40 years have a lower ovarian reserve, estimated by anti-Müllerian hormone (AMH) and total antral follicle count (AFC), than women of the same age with no history of infertility? SUMMARY ANSWER: Serum AMH and AFC were not lower in infertile p...

  2. Effect of pregnancy-associated plasma protein-A (PAPP-A) single-nucleotide polymorphisms on the level and activity of PAPP-A and the hormone profile in fluid from normal human small antral follicles

    DEFF Research Database (Denmark)

    Bøtkjær, Jane Alrø; Borgbo, Tanni; Kløverpris, Søren

    2016-01-01

    Objective: To reveal a possible relationship between two single nucleotide polymorphisms (SNPs) in PAPP-A—1224 (rs7020782) and 327 (rs12375498)—and the level and activity of PAPP-A in follicular fluid (FF) of human small antral follicles, and to analyze the intrafollicular hormone levels. Design:...

  3. Antral follicle count in normal (fertility-proven) and infertile Indian women.

    Science.gov (United States)

    Agarwal, Arjit; Verma, Ashish; Agarwal, Shubhra; Shukla, Ram Chandra; Jain, Madhu; Srivastava, Arvind

    2014-07-01

    Antral follicle count (AFC) has been labeled as the most accurate biomarker to assess female fecundity. Unfortunately, no baseline Indian data exists, and we continue using surrogate values from the Western literature (inferred from studies on women, grossly different than Indian women in morphology and genetic makeup). (1) To establish the role of AFC as a function of ovarian reserve in fertility-proven and in subfertile Indian women. (2) To establish baseline cut-off AFC values for Indian women. Prospective observational case-control study. Thirty patients undergoing workup for infertility were included and compared to equal number of controls (women with proven fertility). The basal ovarian volume and AFC were measured by endovaginal. USG the relevant clinical data and hormonal assays were charted for every patient. SPSS platform was used to perform the Student's t-test and Mann-Whitney U-test for intergroup comparisons. Correlations were determined by Pearson's ranked correlation coefficient. Regression analysis revealed the highest correlation of AFC and age in fertile and infertile patients with difference in mean AFC of both the groups. Comparison of the data recorded for cases and controls showed no significant difference in the mean ovarian volume. AFC has the closest association with chronological age in normal and infertile Indian women. The same is lower in infertile women than in matched controls. Baseline and cut-off values in Indian women are lower than that mentioned in the Western literature.

  4. Ultrasonographic gastric antral area and gastric contents volume in children.

    Science.gov (United States)

    Schmitz, Achim; Thomas, Schraner; Melanie, Fruehauf; Rabia, Liamlahi; Klaghofer, Richard; Weiss, Markus; Kellenberger, Christian

    2012-02-01

    Cross-sectional gastric antral area (GAA) measurements by ultrasonography (US) have been proposed for preoperative assessment of gastric volume in adults but not been validated in children. This study investigates whether in children gastric volumes can be predicted by US performed in different patient positions. Gastric fluid and air volumes were examined by magnetic resonance imaging before or up to 120 min after ingestion of 7 ml·kg(-1) diluted raspberry syrup in healthy volunteers who had fasted overnight. GAA was measured with US three times each in supine (SUP), elevated 45° degree supine (E45) and right decubital (RDC) position using imaging planes defined by vascular landmarks. Correlation coefficients (Pearson) between GAA and gastric volumes were calculated and Bland-Altman analysis performed. Sixteen children aged from 6.4 to 12.8 (9.2) years were included in 23 examinations: 6 after overnight fasting, 3 directly after, and 14 with a delay of 74 ± 35 min after fluid intake. GAA was 221 ± 116, 218 ± 112, and 347 ± 188 mm(2) for SUP, E45, and RDC position, respectively. The best correlation between body weight corrected total gastric/gastric fluid volume (TGV(w)/GFV(w)) with GAA was found for RDC position (R = 0.79; P < 0.01/R = 0.78; P < 0.01). Bias and precision of calculated and measured GFV(w) was 0 ± 2.8 ml·kg(-1). Correlations between GAA and TGV(w) or GFV(w) in children are best in the RDC position, but not sufficient to predict GFV(w) with a given GAA. Interpretation of isolated GAA values may be misleading. © 2011 Blackwell Publishing Ltd.

  5. Association between antral follicle count and reproductive measures in New Zealand lactating dairy cows maintained in a pasture-based production system.

    Science.gov (United States)

    Martinez, Marcelo F; Sanderson, Neil; Quirke, Laurel D; Lawrence, Stephen B; Juengel, Jennifer L

    2016-02-01

    The antral follicle count (AFC) in cattle is consistent throughout the estrous cycle of individual cows, and cows with a lower AFC have lower fertility. We assessed the AFC at random stages of the estrous cycle, examined the correlation between AFC classifications, and determined the relationship between the most rapid and practical laboratory-based AFC classification (AFC of follicles of ≥ 2 mm in diameter) and fertility measures in New Zealand lactating dairy cows. Cows detected in estrus (n = 202) or not (n = 239) during the first 4 weeks of the breeding season were subjected to ultrasonography and classified as having a high, medium, or low AFC at the time of scanning (on-site classification). Images from ultrasound scanning were recorded onto video for accurate follicle counting in an imaging laboratory. A strong association (P Cows with a high AFC had a shorter (P cows with a low AFC. The AFC was positively associated (P cows (7.6 ± 0.3 ng/mL) than in low-AFC cows (6.5 ± 0.3 ng/mL), whether these were pregnant (7.7 ± 0.3 ng/mL) or not (6.3 ± 0.2 ng/mL). A rapid on-site scoring system determined that cows classified as having a high AFC had a shorter (P cows with a low on-site AFC. Collectively, we have confirmed an association between AFC2 and fertility, and these results support the hypothesis that cows with a greater number of antral follicles are more fertile than cows with a lesser number of follicles. Although the on-site classification was related to resumption of estrous cycles after calving, associations with other fertility measurements could not be observed, highlighting a need for further refinement of the on-site classification system for rapid phenotyping of the AFC. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Classification of the maxillary sinus according to area of the medial antral wall: a comparison of two ethnic groups.

    Science.gov (United States)

    Lee, Fernandes Carmen; Fernandes, C M C; Murrell, H C

    2009-06-01

    This study is an anatomical study designed to benefit surgeons working in the region of the maxillary sinus. This paper investigates ethnic and gender variations in the shape of the maxillary sinus in dried crania from the Raymond Dart collection of human skeletons. The paper claims that an estimate of the area of the medial antral wall of the maxillary sinus is one of the best ethnic/gender group predictors. Helical, multislice computed tomography was performed using 1mm coronal slices length, depth, width and volume measurements for each sinus were taken. Classification by shape and estimated area of medial wall was attempted. Shape classification was found to be unsuccessful whilst medial wall classification into ethnic/gender groupings gave encouraging results. The area of the medial wall is related to ethnic/gender groups.

  7. Age-related changes in luteal dynamics: preliminary associations with antral follicular dynamics and hormone production during the human menstrual cycle.

    Science.gov (United States)

    Baerwald, Angela; Vanden Brink, Heidi; Hunter, Caitlin; Beuker, Denae; Lim, Hyun; Lee, Chel Hee; Chizen, Donna

    2018-04-01

    The aim of the study was to test the hypothesis that the development of luteal phase dominant follicles (LPDFs) as women age is associated with abnormal luteal function. Luteal and antral follicle diameter were quantified in ovulatory women of midreproductive age (MRA; 18-35 y; n = 9) and advanced reproductive age (ARA; 45-55 y; n = 16) every 1 to 3 days during one complete interovulatory interval. Blood was drawn at each visit and assayed for progesterone, estradiol, inhibin A, follicle-stimulating hormone, and luteinizing hormone. Luteal diameter and hormone profiles were compared within MRA and ARA women with versus without LPDFs. Luteal growth and regression profiles were similar in MRA women with typical versus no LPDFs (13.9, 14.8 mm; P > 0.1); however, luteal phase estradiol and progesterone were greater in MRA women with typical (91.1 ng/L, 8.81 μg/L) versus no (48.8 ng/L, 7.32 μg/L) LPDFs, respectively (LPDF effect, P < 0.1). In the ARA group, mean luteal diameter was lowest in women with atypical LPDFs (12.3 mm), greatest in those with typical LPDFs (16.0 mm), and moderate in those with no LPDFs (13.6 mm), (P < 0.1). Reduced luteal growth in ARA women with atypical versus typical and/or no LPDFs occurred simultaneously to greater luteal phase estradiol (199 vs 69.0, 78.4 ng/L) lower progesterone (7.38 vs 10.7, 13.8 ug/L), and lower inhibin A (36.3, 35.6, 51.2) (P < 0.1). The development of LPDFs as women age was associated with reduced luteal growth, greater estradiol, lower progesterone, and lower inhibin A. These findings provide preliminary evidence that variations in antral folliculogenesis contribute to luteal insufficiency during the menopausal transition.

  8. Web Page Recommendation Using Web Mining

    OpenAIRE

    Modraj Bhavsar; Mrs. P. M. Chavan

    2014-01-01

    On World Wide Web various kind of content are generated in huge amount, so to give relevant result to user web recommendation become important part of web application. On web different kind of web recommendation are made available to user every day that includes Image, Video, Audio, query suggestion and web page. In this paper we are aiming at providing framework for web page recommendation. 1) First we describe the basics of web mining, types of web mining. 2) Details of each...

  9. Antral localization worsens the efficacy of enteral stents in malignant digestive tumors.

    Science.gov (United States)

    Dolz, Carlos; Vilella, Àngels; González Carro, Pedro; González Huix, Ferran; Espinós, Juan Carlos; Santolaria, Santos; Pérez Roldán, Francisco; Figa, Montserrat; Loras, Carmen; Andreu, Hernán

    2011-02-01

    Malignant gastric outlet obstruction can be treated by means of enteral stenting or surgical gastrojejunalanatomosis. We evaluated in a prospective and multicentre study the efficacy of the enteral stent on food intake, the quality of life impact, and the relationship between efficacy and determined clinical and technical parameters. Seventy one patients affected by symptoms arising from gastroduodenal obstruction due to malignant tumors, with criteria of irresecability, metastatic disease or very high surgical risk, were treated by means of self expanding metal stents. We used the GOOSS index to evaluate efficacy, and the Euro Qol-5D index to evaluate quality of life. Before stenting patients with GOOSS 0 and 1 were 68 (98.5%). After stenting patients with GOOSS 2 and 3 (semisolid and solid food) were 58 (84,1%) (P<.0001). The Euro Qol-5D index measured before and a month after stenting were 10.17 and 10.04 respectively (P=.6). The median survival was 91 days (9-552). The enteral stents for localised tumors in the duodenum and the gastrojejunalanastomosis were effective in 26 patients (70.2%) and 13 patients respectively (86.6%), while the enteral stents of tumors in the antrum were effective in only 5 patients (29.4%). The palliative treatment of malignant gastric outlet obstruction with a uncovered metal stent produces a significant improvement of oral food intake and maintains the overall quality of life index. The antral localization is associated with a lower efficacy of the procedure. Copyright © 2010 Elsevier España, S.L. All rights reserved.

  10. Web components and the semantic web

    OpenAIRE

    Casey, Maire; Pahl, Claus

    2003-01-01

    Component-based software engineering on the Web differs from traditional component and software engineering. We investigate Web component engineering activites that are crucial for the development,com position, and deployment of components on the Web. The current Web Services and Semantic Web initiatives strongly influence our work. Focussing on Web component composition we develop description and reasoning techniques that support a component developer in the composition activities,fo cussing...

  11. WebVis: a hierarchical web homepage visualizer

    Science.gov (United States)

    Renteria, Jose C.; Lodha, Suresh K.

    2000-02-01

    WebVis, the Hierarchical Web Home Page Visualizer, is a tool for managing home web pages. The user can access this tool via the WWW and obtain a hierarchical visualization of one's home web pages. WebVis is a real time interactive tool that supports many different queries on the statistics of internal files such as sizes, age, and type. In addition, statistics on embedded information such as VRML files, Java applets, images and sound files can be extracted and queried. Results of these queries are visualized using color, shape and size of different nodes of the hierarchy. The visualization assists the user in a variety of task, such as quickly finding outdated information or locate large files. WebVIs is one solution to the growing web space maintenance problem. Implementation of WebVis is realized with Perl and Java. Perl pattern matching and file handling routines are used to collect and process web space linkage information and web document information. Java utilizes the collected information to produce visualization of the web space. Java also provides WebVis with real time interactivity, while running off the WWW. Some WebVis examples of home web page visualization are presented.

  12. Relationship of antral follicular blood flow velocity to superovulatory responses in ewes.

    Science.gov (United States)

    Oliveira, M E F; Bartlewski, P M; Jankowski, N; Padilha-Nakaghi, L C; Oliveira, L G; Bicudo, S D; Fonseca, J F; Vicente, W R R

    2017-07-01

    The aim of this study was to examine the association between antral follicular blood flow velocity and the response of ewes to hormonal ovarian superstimulation. Ten Santa Inês ewes were subjected to a short- (7days; Group 1) or long-term (13days; Group 2) progesterone (CIDR ® ; InterAg, Hamilton, New Zealand) priming, and a superovulatory treatment with porcine follicle-stimulating hormone (pFSH; Folltropin ® -V; Bioniche Animal Health, Belleville, ON, Canada), given twice daily for four consecutive days in decreasing doses and initiated four or ten days after CIDR insertion, respectively. Embryos were recovered surgically seven days after the last pFSH dose. From one day prior to until the end of the pFSH regimen (Days -1 to 3), all ewes underwent daily transrectal ultrasonography of ovaries. The number of high-velocity pixels (HVPs; 0.055-0.11m/s or upper 50% of recordable velocities) on Day 1 correlated directly with the number of corpora lutea (CL; r=0.92, P=0.0002) and of viable embryos (r=0.77, P=0.01). Correlations were also recorded between the number of HVPs on Day 3 and the recovery rate (r=-0.69, P=0.03), viability rate (r=-0.64, P=0.05), and percentage of degenerated embryos (r=0.65, P=0.04). The percentage of HVPs relative to the total area of ovarian cross section on Day 1 was correlated with the number of CL (r=0.95, Pflow has the makings of a useful non-invasive method to predict the outcome of the superovulatory treatment in ewes. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Web-based control application using WebSocket

    International Nuclear Information System (INIS)

    Furukawa, Y.

    2012-01-01

    The WebSocket allows asynchronous full-duplex communication between a Web-based (i.e. Java Script-based) application and a Web-server. WebSocket started as a part of HTML5 standardization but has now been separated from HTML5 and has been developed independently. Using WebSocket, it becomes easy to develop platform independent presentation layer applications for accelerator and beamline control software. In addition, a Web browser is the only application program that needs to be installed on client computer. The WebSocket-based applications communicate with the WebSocket server using simple text-based messages, so WebSocket is applicable message-based control system like MADOCA, which was developed for the SPring-8 control system. A simple WebSocket server for the MADOCA control system and a simple motor control application were successfully made as a first trial of the WebSocket control application. Using Google-Chrome (version 13.0) on Debian/Linux and Windows 7, Opera (version 11.0) on Debian/Linux and Safari (version 5.0.3) on Mac OS X as clients, the motors can be controlled using a WebSocket-based Web-application. Diffractometer control application use in synchrotron radiation diffraction experiment was also developed. (author)

  14. Age, anti-müllerian hormone, antral follicles count to predict amenorrhea or oligomenorrhea after chemotherapy with cyclophosphamide.

    Science.gov (United States)

    D'Avila, Ângela Marcon; Biolchi, Vanderlei; Capp, Edison; Corleta, Helena von Eye

    2015-12-14

    A cohort study was performed to identify ovarian reserve markers (ORM) that predicts amenorrhea or oligomenorrhea 6 months after cyclophosphamide CTX in women with breast cancer. 52 eumenorrheic patients with breast cancer were enrolled. FSH, anti-Müllerian hormone (AMH), antral follicles count (AFC) were measured before and 6 months after CTX. A logistic regression for independent samples and determination of the ROC curve were performed. The age of 32 years presented 96 % of sensitivity and 39 % of specificity to predict amenorrhea or oligomenorrhea with ROC area under the curve (AUC) of 0.77. ovarian reserve marker (ORM) with power to predict amenorrhea or oligomenorrhea in women after CTX were AMH amenorrhea was 1.87 ng/mL (sensitivity 82 %, specificity 83 %, AUC 0.84) and AFC cutoff was 9 follicles (sensitivity 71 %, specificity 78 %, AUC 0.73). ≥32-years-old women, AMH amenorrhea or oligomenorrhea after CTX with cyclophosphamide. The ORM age (≥32 years) analyzed together with AMH or AFC increases sensitivity and specificity in predicting amenorrhea or oligomenorrhea.

  15. Beginning ASPNET Web Pages with WebMatrix

    CERN Document Server

    Brind, Mike

    2011-01-01

    Learn to build dynamic web sites with Microsoft WebMatrix Microsoft WebMatrix is designed to make developing dynamic ASP.NET web sites much easier. This complete Wrox guide shows you what it is, how it works, and how to get the best from it right away. It covers all the basic foundations and also introduces HTML, CSS, and Ajax using jQuery, giving beginning programmers a firm foundation for building dynamic web sites.Examines how WebMatrix is expected to become the new recommended entry-level tool for developing web sites using ASP.NETArms beginning programmers, students, and educators with al

  16. Non-visual Web Browsing: Beyond Web Accessibility.

    Science.gov (United States)

    Ramakrishnan, I V; Ashok, Vikas; Billah, Syed Masum

    2017-07-01

    People with vision impairments typically use screen readers to browse the Web. To facilitate non-visual browsing, web sites must be made accessible to screen readers, i.e., all the visible elements in the web site must be readable by the screen reader. But even if web sites are accessible, screen-reader users may not find them easy to use and/or easy to navigate. For example, they may not be able to locate the desired information without having to listen to a lot of irrelevant contents. These issues go beyond web accessibility and directly impact web usability. Several techniques have been reported in the accessibility literature for making the Web usable for screen reading. This paper is a review of these techniques. Interestingly, the review reveals that understanding the semantics of the web content is the overarching theme that drives these techniques for improving web usability.

  17. Challenges in biotechnology of reproduction in dairy cattle: the antral follicle counting as a fertility parameter

    Directory of Open Access Journals (Sweden)

    Zangirolamo AF

    2017-08-01

    Full Text Available Dairy farming plays an important role in the socioeconomic scenario, and several characteristics point to an enormous potential for growth in the productivity of the herd. This is a complex activity that needs to be carried out efficiently in all the links that integrate it. Moreover, due to the physiological and metabolic aspects of the animals with the aptitude for the milk production, several challenges arise, especially in the reproductive scope. In this context, breeding biotechniques appear as a good alternative to the increase in reproductive rates and genetic improvement of dairy cattle. In addition, ovarian antral follicle counts (AFC have been studied as a way to improve the selection of females to compose reproductive programs, because it has been shown to be a factor of high repeatability over the reproductive life in the same animal. Although studies have shown controversial results regarding the relationship between AFC and fertility, it is still necessary to investigate the possible variables that may interfere with the performance of donors in each biotechnology used. Thus, this review intends to gather and discuss the relationship of AFC with physiological aspects of dairy cows, its application as a parameter of selection of animals with good fertility and, the challenges for the application of reproductive biotechniques in dairy cattle.

  18. Web Caching

    Indian Academy of Sciences (India)

    leveraged through Web caching technology. Specifically, Web caching becomes an ... Web routing can improve the overall performance of the Internet. Web caching is similar to memory system caching - a Web cache stores Web resources in ...

  19. WebSelF: A Web Scraping Framework

    DEFF Research Database (Denmark)

    Thomsen, Jakob; Ernst, Erik; Brabrand, Claus

    2012-01-01

    We present, WebSelF, a framework for web scraping which models the process of web scraping and decomposes it into four conceptually independent, reusable, and composable constituents. We have validated our framework through a full parameterized implementation that is flexible enough to capture...... previous work on web scraping. We have experimentally evaluated our framework and implementation in an experiment that evaluated several qualitatively different web scraping constituents (including previous work and combinations hereof) on about 11,000 HTML pages on daily versions of 17 web sites over...... a period of more than one year. Our framework solves three concrete problems with current web scraping and our experimental results indicate that com- position of previous and our new techniques achieve a higher degree of accuracy, precision and specificity than existing techniques alone....

  20. Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis.

    Science.gov (United States)

    Villarreal-Calderon, Rodolfo; Luévano-González, Arturo; Aragón-Flores, Mariana; Zhu, Hongtu; Yuan, Ying; Xiang, Qun; Yan, Benjamin; Stoll, Kathryn Anne; Cross, Janet V; Iczkowski, Kenneth A; Mackinnon, Alexander Craig

    2014-06-01

    Chronic inflammation and infection are major risk factors for gastric carcinogenesis in adults. As chronic gastritis is common in Mexican children, diagnosis of Helicobacter pylori and other causes of gastritis are critical for the identification of children who would benefit from closer surveillance. Antral biopsies from 82 Mexican children (mean age, 8.3 ± 4.8 years) with chronic gastritis (36 H pylori+, 46 H pylori-) were examined for gastritis activity, atrophy, intestinal metaplasia (IM), and immunohistochemical expression of gastric carcinogenesis biomarkers caudal type homeobox 2 (CDX2), ephrin type-B receptor 4 (EphB4), matrix metalloproteinase 3 (MMP3), macrophage migration inhibitory factor (MIF), p53, β-catenin, and E-cadherin. Atrophy was diagnosed in 7 (9%) of 82, and IM, in 5 (6%) of 82 by routine histology, whereas 6 additional children (7%) (3 H pylori+) exhibited aberrant CDX2 expression without IM. Significant positive correlations were seen between EphB4, MMP3, and MIF (Pgastritis. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. 07051 Executive Summary -- Programming Paradigms for the Web: Web Programming and Web Services

    OpenAIRE

    Hull, Richard; Thiemann, Peter; Wadler, Philip

    2007-01-01

    The world-wide web raises a variety of new programming challenges. To name a few: programming at the level of the web browser, data-centric approaches, and attempts to automatically discover and compose web services. This seminar brought together researchers from the web programming and web services communities and strove to engage them in communication with each other. The seminar was held in an unusual style, in a mixture of short presentations and in-depth discussio...

  2. Semantic Web Requirements through Web Mining Techniques

    OpenAIRE

    Hassanzadeh, Hamed; Keyvanpour, Mohammad Reza

    2012-01-01

    In recent years, Semantic web has become a topic of active research in several fields of computer science and has applied in a wide range of domains such as bioinformatics, life sciences, and knowledge management. The two fast-developing research areas semantic web and web mining can complement each other and their different techniques can be used jointly or separately to solve the issues in both areas. In addition, since shifting from current web to semantic web mainly depends on the enhance...

  3. Prey interception drives web invasion and spider size determines successful web takeover in nocturnal orb-web spiders.

    Science.gov (United States)

    Gan, Wenjin; Liu, Shengjie; Yang, Xiaodong; Li, Daiqin; Lei, Chaoliang

    2015-09-24

    A striking feature of web-building spiders is the use of silk to make webs, mainly for prey capture. However, building a web is energetically expensive and increases the risk of predation. To reduce such costs and still have access to abundant prey, some web-building spiders have evolved web invasion behaviour. In general, no consistent patterns of web invasion have emerged and the factors determining web invasion remain largely unexplored. Here we report web invasion among conspecifics in seven nocturnal species of orb-web spiders, and examined the factors determining the probability of webs that could be invaded and taken over by conspecifics. About 36% of webs were invaded by conspecifics, and 25% of invaded webs were taken over by the invaders. A web that was built higher and intercepted more prey was more likely to be invaded. Once a web was invaded, the smaller the size of the resident spider, the more likely its web would be taken over by the invader. This study suggests that web invasion, as a possible way of reducing costs, may be widespread in nocturnal orb-web spiders. © 2015. Published by The Company of Biologists Ltd.

  4. Prey interception drives web invasion and spider size determines successful web takeover in nocturnal orb-web spiders

    Directory of Open Access Journals (Sweden)

    Wenjin Gan

    2015-10-01

    Full Text Available A striking feature of web-building spiders is the use of silk to make webs, mainly for prey capture. However, building a web is energetically expensive and increases the risk of predation. To reduce such costs and still have access to abundant prey, some web-building spiders have evolved web invasion behaviour. In general, no consistent patterns of web invasion have emerged and the factors determining web invasion remain largely unexplored. Here we report web invasion among conspecifics in seven nocturnal species of orb-web spiders, and examined the factors determining the probability of webs that could be invaded and taken over by conspecifics. About 36% of webs were invaded by conspecifics, and 25% of invaded webs were taken over by the invaders. A web that was built higher and intercepted more prey was more likely to be invaded. Once a web was invaded, the smaller the size of the resident spider, the more likely its web would be taken over by the invader. This study suggests that web invasion, as a possible way of reducing costs, may be widespread in nocturnal orb-web spiders.

  5. Using Open Web APIs in Teaching Web Mining

    Science.gov (United States)

    Chen, Hsinchun; Li, Xin; Chau, M.; Ho, Yi-Jen; Tseng, Chunju

    2009-01-01

    With the advent of the World Wide Web, many business applications that utilize data mining and text mining techniques to extract useful business information on the Web have evolved from Web searching to Web mining. It is important for students to acquire knowledge and hands-on experience in Web mining during their education in information systems…

  6. Correct software in web applications and web services

    CERN Document Server

    Thalheim, Bernhard; Prinz, Andreas; Buchberger, Bruno

    2015-01-01

    The papers in this volume aim at obtaining a common understanding of the challenging research questions in web applications comprising web information systems, web services, and web interoperability; obtaining a common understanding of verification needs in web applications; achieving a common understanding of the available rigorous approaches to system development, and the cases in which they have succeeded; identifying how rigorous software engineering methods can be exploited to develop suitable web applications; and at developing a European-scale research agenda combining theory, methods a

  7. Semantic Web Technologies for the Adaptive Web

    DEFF Research Database (Denmark)

    Dolog, Peter; Nejdl, Wolfgang

    2007-01-01

    Ontologies and reasoning are the key terms brought into focus by the semantic web community. Formal representation of ontologies in a common data model on the web can be taken as a foundation for adaptive web technologies as well. This chapter describes how ontologies shared on the semantic web...... provide conceptualization for the links which are a main vehicle to access information on the web. The subject domain ontologies serve as constraints for generating only those links which are relevant for the domain a user is currently interested in. Furthermore, user model ontologies provide additional...... means for deciding which links to show, annotate, hide, generate, and reorder. The semantic web technologies provide means to formalize the domain ontologies and metadata created from them. The formalization enables reasoning for personalization decisions. This chapter describes which components...

  8. Usare WebDewey

    OpenAIRE

    Baldi, Paolo

    2016-01-01

    This presentation shows how to use the WebDewey tool. Features of WebDewey. Italian WebDewey compared with American WebDewey. Querying Italian WebDewey. Italian WebDewey and MARC21. Italian WebDewey and UNIMARC. Numbers, captions, "equivalente verbale": Dewey decimal classification in Italian catalogues. Italian WebDewey and Nuovo soggettario. Italian WebDewey and LCSH. Italian WebDewey compared with printed version of Italian Dewey Classification (22. edition): advantages and disadvantages o...

  9. A morphometric study of antral G-cell density in a sample of adult general population: comparison of three different methods and correlation with patient demography, helicobacter pylori infection, histomorphology and circulating gastrin levels

    DEFF Research Database (Denmark)

    Petersson, Fredrik; Borch, Kurt; Rehfeld, Jens F

    2008-01-01

    whether these methods are intercorrelated and the relation of these methods to plasma gastrin concentrations, demography, the occurrence of H. pylori infection and chronic gastritis. Gastric antral mucosal biopsy sections from 273 adults (188 with and 85 without H pylori infection) from a general...... population sample were examined immunohistochemically for G-cells using cell counting, stereology (point counting) and computerized image analysis. Gastritis was scored according to the updated Sydney system. Basal plasma gastrin concentrations were measured by radioimmunoassay. The three methods for G...

  10. Web TA Production (WebTA)

    Data.gov (United States)

    US Agency for International Development — WebTA is a web-based time and attendance system that supports USAID payroll administration functions, and is designed to capture hours worked, leave used and...

  11. Politiken, Alt om Ikast Brande (web), Lemvig Folkeblad (Web), Politiken (web), Dabladet Ringkjøbing Skjern (web)

    DEFF Research Database (Denmark)

    Lauritsen, Jens

    2014-01-01

    Politiken 01.01.2014 14:16 Danskerne skød nytåret ind med et brag, men for enkeltes vedkommende gik det galt, da nytårskrudtet blev tændt. Skadestuerne har behandlet 73 personer for fyrværkeriskader mellem klokken 18 i aftes og klokken 06 i morges. Det viser en optælling, som Politiken har...... foretaget på baggrund af tal fra Ulykkes Analyse Gruppen på Odense Universitetshospital. Artiklen er også bragt i: Alt om Ikast Brande (web), Lemvig Folkeblad (web), Politiken (web), Dagbladet Ringkjøbing Skjern (web)....

  12. Using Web Server Logs in Evaluating Instructional Web Sites.

    Science.gov (United States)

    Ingram, Albert L.

    2000-01-01

    Web server logs contain a great deal of information about who uses a Web site and how they use it. This article discusses the analysis of Web logs for instructional Web sites; reviews the data stored in most Web server logs; demonstrates what further information can be gleaned from the logs; and discusses analyzing that information for the…

  13. WEB STRUCTURE MINING

    Directory of Open Access Journals (Sweden)

    CLAUDIA ELENA DINUCĂ

    2011-01-01

    Full Text Available The World Wide Web became one of the most valuable resources for information retrievals and knowledge discoveries due to the permanent increasing of the amount of data available online. Taking into consideration the web dimension, the users get easily lost in the web’s rich hyper structure. Application of data mining methods is the right solution for knowledge discovery on the Web. The knowledge extracted from the Web can be used to raise the performances for Web information retrievals, question answering and Web based data warehousing. In this paper, I provide an introduction of Web mining categories and I focus on one of these categories: the Web structure mining. Web structure mining, one of three categories of web mining for data, is a tool used to identify the relationship between Web pages linked by information or direct link connection. It offers information about how different pages are linked together to form this huge web. Web Structure Mining finds hidden basic structures and uses hyperlinks for more web applications such as web search.

  14. Web Engineering

    Energy Technology Data Exchange (ETDEWEB)

    White, Bebo

    2003-06-23

    Web Engineering is the application of systematic, disciplined and quantifiable approaches to development, operation, and maintenance of Web-based applications. It is both a pro-active approach and a growing collection of theoretical and empirical research in Web application development. This paper gives an overview of Web Engineering by addressing the questions: (a) why is it needed? (b) what is its domain of operation? (c) how does it help and what should it do to improve Web application development? and (d) how should it be incorporated in education and training? The paper discusses the significant differences that exist between Web applications and conventional software, the taxonomy of Web applications, the progress made so far and the research issues and experience of creating a specialization at the master's level. The paper reaches a conclusion that Web Engineering at this stage is a moving target since Web technologies are constantly evolving, making new types of applications possible, which in turn may require innovations in how they are built, deployed and maintained.

  15. Web Accessibility in Romania: The Conformance of Municipal Web Sites to Web Content Accessibility Guidelines

    OpenAIRE

    Costin PRIBEANU; Ruxandra-Dora MARINESCU; Paul FOGARASSY-NESZLY; Maria GHEORGHE-MOISII

    2012-01-01

    The accessibility of public administration web sites is a key quality attribute for the successful implementation of the Information Society. The purpose of this paper is to present a second review of municipal web sites in Romania that is based on automated accessibility checking. A number of 60 web sites were evaluated against WCAG 2.0 recommendations. The analysis of results reveals a relatively low web accessibility of municipal web sites and highlights several aspects. Firstly, a slight ...

  16. 07051 Working Group Outcomes -- Programming Paradigms for the Web: Web Programming and Web Services

    OpenAIRE

    Hull, Richard; Thiemann, Peter; Wadler, Philip

    2007-01-01

    Participants in the seminar broke into groups on ``Patterns and Paradigms'' for web programming, ``Web Services,'' ``Data on the Web,'' ``Software Engineering'' and ``Security.'' Here we give the raw notes recorded during these sessions.

  17. Concentration of activin A and follistatin in follicular fluid from human small antral follicles associated to gene expression of the corresponding granulosa cells

    DEFF Research Database (Denmark)

    Jeppesen, J V; Nielsen, M E; Kristensen, S G

    2012-01-01

    The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-receptor (FSHR), LH-receptor (LHR), AMH-receptor2 (AMHR2), CYP19...... activin A levels increased in follicles exceeding 10 mm in diameter. Levels of activin A and inhibin B showed a highly significant inverse association. Follistatin showed highly significant positive associations with AMH and inhibin B levels and with FSHR and AR gene expression in GC. This study revealed......a, and androgen-receptor (AR) in the corresponding granulosa cells (GC). FF from 144 follicles (3-12 mm in diameter) was included whereas mRNA expression profiles were established in GC from 66 of the 144 follicles. Levels of follistatin remained constant in relation to follicular diameter, whereas...

  18. Antral follicles population in heifers and cows of Nelore and Girolando breeds

    Directory of Open Access Journals (Sweden)

    Jair Sábio de Oliveira Junior

    2015-12-01

    Full Text Available The aim of this study was to evaluate ovarian antral follicle populations (OAFP of Nelore and Girolando breed heifers (12–18 months old and cows (24–60 months old. Animals were assigned to four groups: (1 Nelore cows (n = 18, (2 Girolando cows (n = 20, (3 Nelore heifers (n = 7, and (4 Girolando heifers (n = 7. Cows were treated to synchronize follicular wave emergence by implantation of an intravaginal device containing 1.9 g of progesterone, as well as intramuscular administration of 2 mg of estradiol benzoate and 25 mg of dinoprost. This synchronization treatment was administered at a random day of the estrous cycle of each cow, designated D0. Intravaginal devices were removed on D7, and on D11, OAFP counts were performed by transvaginal ovarian ultrasound. For each cow, all follicles ?3 mm in diameter were counted in both ovaries and counts were performed three times at 35-day intervals. Counts were also obtained from heifers, but these animals were not treated for synchronization of follicular wave emergence. Analysis of variance (ANOVA with Tukey’s test and Pearson’s correlation test were used to compare mean OAFPs between counts as well as mean OAFPs between breed and age groups. No differences were observed in mean OAFPs between Nelore and Girolando cows (30.9 vs. 26.7, respectively; P > 0.05 or heifers (16.2 vs. 18.1, respectively; P > 0.05. However, within each breed, there were differences in mean OAFPs between heifers and cows (for Nelore cattle: 16.2 and 30.9, respectively; for Girolando cattle: 18.1 and 26.7, respectively; both P < 0.05. In conclusion, OAFPs were similar between Nelore and Girolando breeds and were influenced by age. Furthermore, we observed a high correlation for individual animals between the mean numbers of follicles counted in both ovaries and total number of follicles counted in either the right or left ovary, indicating that the evaluation of a single ovary is sufficient to estimate the OAFP of an

  19. Web-ADARE: A Web-Aided Data Repairing System

    KAUST Repository

    Gu, Binbin

    2017-03-08

    Data repairing aims at discovering and correcting erroneous data in databases. In this paper, we develop Web-ADARE, an end-to-end web-aided data repairing system, to provide a feasible way to involve the vast data sources on the Web in data repairing. Our main attention in developing Web-ADARE is paid on the interaction problem between web-aided repairing and rule-based repairing, in order to minimize the Web consultation cost while reaching predefined quality requirements. The same interaction problem also exists in crowd-based methods but this is not yet formally defined and addressed. We first prove in theory that the optimal interaction scheme is not feasible to be achieved, and then propose an algorithm to identify a scheme for efficient interaction by investigating the inconsistencies and the dependencies between values in the repairing process. Extensive experiments on three data collections demonstrate the high repairing precision and recall of Web-ADARE, and the efficiency of the generated interaction scheme over several baseline ones.

  20. Web-ADARE: A Web-Aided Data Repairing System

    KAUST Repository

    Gu, Binbin; Li, Zhixu; Yang, Qiang; Xie, Qing; Liu, An; Liu, Guanfeng; Zheng, Kai; Zhang, Xiangliang

    2017-01-01

    Data repairing aims at discovering and correcting erroneous data in databases. In this paper, we develop Web-ADARE, an end-to-end web-aided data repairing system, to provide a feasible way to involve the vast data sources on the Web in data repairing. Our main attention in developing Web-ADARE is paid on the interaction problem between web-aided repairing and rule-based repairing, in order to minimize the Web consultation cost while reaching predefined quality requirements. The same interaction problem also exists in crowd-based methods but this is not yet formally defined and addressed. We first prove in theory that the optimal interaction scheme is not feasible to be achieved, and then propose an algorithm to identify a scheme for efficient interaction by investigating the inconsistencies and the dependencies between values in the repairing process. Extensive experiments on three data collections demonstrate the high repairing precision and recall of Web-ADARE, and the efficiency of the generated interaction scheme over several baseline ones.

  1. Web Mining

    Science.gov (United States)

    Fürnkranz, Johannes

    The World-Wide Web provides every internet citizen with access to an abundance of information, but it becomes increasingly difficult to identify the relevant pieces of information. Research in web mining tries to address this problem by applying techniques from data mining and machine learning to Web data and documents. This chapter provides a brief overview of web mining techniques and research areas, most notably hypertext classification, wrapper induction, recommender systems and web usage mining.

  2. Band ligation of gastric antral vascular ectasia is a safe and effective endoscopic treatment.

    Science.gov (United States)

    Keohane, John; Berro, Wael; Harewood, Gavin C; Murray, Frank E; Patchett, Stephen E

    2013-07-01

    Gastric antral vascular ectasia (GAVE) or 'watermelon stomach' is a rare and often misdiagnosed cause of occult upper gastrointestinal bleeding. Treatment includes conservative measures such as transfusion and endoscopic therapy. A recent report suggests that endoscopic band ligation (EBL) offers an effective alternative treatment. The aim of the present study is to demonstrate our experiences with this novel technique, and to compare argon plasma coagulation (APC) with EBL in terms of safety and efficacy. A retrospective analysis of all endoscopies with a diagnosis of GAVE was carried out between 2004 and 2010. Case records were examined for information pertaining to the number of procedures carried out, mean blood transfusions, mean hemoglobin, and complications. A total of 23 cases of GAVE were treated. The mean age was 73.9 (55-89) years. Female to male ratio was 17:6 and mean follow up was 26 months. Eight patients were treated with EBL with a mean number of treatments of 2.5 (1-5). This resulted in a statistically significant improvement in the endoscopic appearance and a trend towards fewer transfusions. Of the eight patients treated with EBL, six (75%) patients had previously failed APC treatment despite having a mean of 4.7 sessions. Band ligation was not associated with any short- or medium-term complications. The 15 patients who had APC alone had a mean of four (1-11) treatments. Only seven (46.7%) of these patients had any endoscopic improvement with a mean of four sessions. EBL represents a safe and effective treatment for GAVE. © 2012 The Authors. Digestive Endoscopy © 2012 Japan Gastroenterological Endoscopy Society.

  3. Understanding User-Web Interactions via Web Analytics

    CERN Document Server

    Jansen, Bernard J

    2009-01-01

    This lecture presents an overview of the Web analytics process, with a focus on providing insight and actionable outcomes from collecting and analyzing Internet data. The lecture first provides an overview of Web analytics, providing in essence, a condensed version of the entire lecture. The lecture then outlines the theoretical and methodological foundations of Web analytics in order to make obvious the strengths and shortcomings of Web analytics as an approach. These foundational elements include the psychological basis in behaviorism and methodological underpinning of trace data as an empir

  4. The design and implementation of web mining in web sites security

    Science.gov (United States)

    Li, Jian; Zhang, Guo-Yin; Gu, Guo-Chang; Li, Jian-Li

    2003-06-01

    The backdoor or information leak of Web servers can be detected by using Web Mining techniques on some abnormal Web log and Web application log data. The security of Web servers can be enhanced and the damage of illegal access can be avoided. Firstly, the system for discovering the patterns of information leakages in CGI scripts from Web log data was proposed. Secondly, those patterns for system administrators to modify their codes and enhance their Web site security were provided. The following aspects were described: one is to combine web application log with web log to extract more information, so web data mining could be used to mine web log for discovering the information that firewall and Information Detection System cannot find. Another approach is to propose an operation module of web site to enhance Web site security. In cluster server session, Density-Based Clustering technique is used to reduce resource cost and obtain better efficiency.

  5. Web archives

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2018-01-01

    This article deals with general web archives and the principles for selection of materials to be preserved. It opens with a brief overview of reasons why general web archives are needed. Section two and three present major, long termed web archive initiatives and discuss the purposes and possible...... values of web archives and asks how to meet unknown future needs, demands and concerns. Section four analyses three main principles in contemporary web archiving strategies, topic centric, domain centric and time-centric archiving strategies and section five discuss how to combine these to provide...... a broad and rich archive. Section six is concerned with inherent limitations and why web archives are always flawed. The last sections deal with the question how web archives may fit into the rapidly expanding, but fragmented landscape of digital repositories taking care of various parts...

  6. Infantile myofibromatosis: a most unusual cause of gastric outlet obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Rohrer, Kellie; Murphy, Robyn; Thresher, Caroline; Jacir, Nabil; Bergman, Kerry [Morristown Memorial Hospital, Department of Radiology, Morristown, NJ (United States)

    2005-08-01

    Non-bilious vomiting in the newborn is common. Etiologies include both surgical and medical conditions. Gastroesophageal reflux, soy or milk protein allergy, and prostaglandin-induced foveolar hyperplasia are among the medical causes. Surgical entities include gastric antral webs, pre-ampullary duodenal and pyloric atresia, and hypertrophic pyloric stenosis. We report the unique case of an 8-day-old girl who presented with gastric outlet obstruction secondary to infantile myofibromatosis. (orig.)

  7. Individualization of the FSH starting dose in IVF/ICSI cycles using the antral follicle count

    Directory of Open Access Journals (Sweden)

    La Marca Antonio

    2013-02-01

    Full Text Available Abstract Background The FSH starting dose is usually chosen according to women’s age, anamnesis, clinical criteria and markers of ovarian reserve. Currently used markers include antral follicle count (AFC, which is considered to have a very high performance in predicting ovarian response to FSH. The objective of the present study to elaborate a nomogram based on AFC for the calculation of the appropriate FSH starting dose in IVF cycles. Methods This is a retrospective study performed at the Mother-Infant Department of Modena University Hospital. IVF patients (n=505 were subjected to blood sampling and transvaginal ultrasound for measurement of serum day3 FSH, estradiol and AFC. The variables predictive of the number of retrieved oocytes were assessed by backwards stepwise multiple regression. The variables reaching the statistical significance were then used in the calculation for the final predictive model. Results A model based on age, AFC and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting dose lower than 225 IU in 50.2% and 18.1% of patients younger and older than 35 years, respectively. Conclusions The daily FSH dose may be calculated on the basis of age and two markers of ovarian reserve, namely AFC and FSH, with the last two variables being the most significant predictors. The nomogram seems easily applicable during the daily clinical practice.

  8. Even Faster Web Sites Performance Best Practices for Web Developers

    CERN Document Server

    Souders, Steve

    2009-01-01

    Performance is critical to the success of any web site, and yet today's web applications push browsers to their limits with increasing amounts of rich content and heavy use of Ajax. In this book, Steve Souders, web performance evangelist at Google and former Chief Performance Yahoo!, provides valuable techniques to help you optimize your site's performance. Souders' previous book, the bestselling High Performance Web Sites, shocked the web development world by revealing that 80% of the time it takes for a web page to load is on the client side. In Even Faster Web Sites, Souders and eight exp

  9. Efficient Web Harvesting Strategies for Monitoring Deep Web Content

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; Hiemstra, Djoerd; van Keulen, Maurice

    2016-01-01

    The change of the web content is rapid. In Focused Web Harvesting [?], which aims at achieving a complete harvest for a given topic, this dynamic nature of the web creates problems for users who need to access a complete set of related web data to their interesting topics. Whether you are a fan

  10. [Effect of Different Stimulating Strength of Electroacupuncture on Gastrointestinal Motility and RhoA/ROCK Signaling in Gastric Antral Smooth Muscle in Diabetic Gastroparesis Rats].

    Science.gov (United States)

    Wu, Xue-Fen; Chen, Xiao-Li; Zheng, Xue-Na; Guo, Xin; Xie, Zhi-Qiang; Liu, Li; Wei, Xin-Ran; Yue, Zeng-Hui

    2018-03-25

    To observe the effect of different strength of electroacupuncture (EA) stimulation on gastrointestinal motility and Ras homolog gene family member (RhoA)/Rho associated coiled-coil forming protein kinase (ROCK) signaling in diabetic gastroparesis (DGP) rats, so as to reveal the underlying mechanisms of EA for improving DGP. Sixty SD rats were randomly and equally divided into blank control, DGP model, weak EA, medium EA, and strong EA groups ( n =12 rats in each). The DGP model was established by intraperitoneal injection of streptozotocin (STZ, 55 mmol/kg, 2%) and high-sugar and high-fat fodder feeding for 8 weeks. EA (0.12, 0.24, 0.36 mA, 20 Hz/100 Hz) was applied to "Zusanli" (ST 36), "Sanyinjiao" (SP 6) and "Liangmen" (ST 21) for 20 min, once daily for 15 successive days. Blood glucose levels were measured weekly with blood glucose meter and blood glucose test paper. Fecal phenol red excretion method was used to display gastric emptying and small intestinal propulsion function. The expression of RhoA protein in the gastric antral smooth muscle tissue was detected by immunohistochemistry and Western blot (WB), separately, and that of ROCK, myosin phosphatase target subunit 1 (MYPT 1) and phosphorylated (p)-MYPT 1 proteins in gastric antrum detected by WB. Compared with the blank control group, the gastric emptying rate and small intestine propulsion rate of the model group were significantly decreased ( P ROCK, MYPT 1 and p-MYPT 1 proteins in the gastric antrum were significantly down-regulated relevant to the control group ( P ROCK, MYPT 1 and p-MYPT 1 proteins were significantly increased in the strong, medium and weak EA stimulation groups ( P ROCK, MYPT 1 and p-MYPT 1 proteins, and obviously superior to the medium stimulation in up-regulating RhoA and MYPT 1 protein levels ( P ROCK, MYPT 1 and p-MYPT 1 proteins ( P ROCK and p-MYPT 1 proteins ( P >0.05). Electroacupuncture stimulation of ST 36-SP 6-ST 21 at 0.12, 0.24 and 0.36 mA can promote the

  11. Web2Quests: Updating a Popular Web-Based Inquiry-Oriented Activity

    Science.gov (United States)

    Kurt, Serhat

    2009-01-01

    WebQuest is a popular inquiry-oriented activity in which learners use Web resources. Since the creation of the innovation, almost 15 years ago, the Web has changed significantly, while the WebQuest technique has changed little. This article examines possible applications of new Web trends on WebQuest instructional strategy. Some possible…

  12. Integration of Web mining and web crawler: Relevance and State of Art

    OpenAIRE

    Subhendu kumar pani; Deepak Mohapatra,; Bikram Keshari Ratha

    2010-01-01

    This study presents the role of web crawler in web mining environment. As the growth of the World Wide Web exceeded all expectations,the research on Web mining is growing more and more.web mining research topic which combines two of the activated research areas: Data Mining and World Wide Web .So, the World Wide Web is a very advanced area for data mining research. Search engines that are based on web crawling framework also used in web mining to find theinteracted web pages. This paper discu...

  13. Efficient Web Harvesting Strategies for Monitoring Deep Web Content

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; Hiemstra, Djoerd; van Keulen, Maurice

    2016-01-01

    Web content changes rapidly [18]. In Focused Web Harvesting [17] which aim it is to achieve a complete harvest for a given topic, this dynamic nature of the web creates problems for users who need to access a set of all the relevant web data to their topics of interest. Whether you are a fan

  14. Dynamic Web Pages: Performance Impact on Web Servers.

    Science.gov (United States)

    Kothari, Bhupesh; Claypool, Mark

    2001-01-01

    Discussion of Web servers and requests for dynamic pages focuses on experimentally measuring and analyzing the performance of the three dynamic Web page generation technologies: CGI, FastCGI, and Servlets. Develops a multivariate linear regression model and predicts Web server performance under some typical dynamic requests. (Author/LRW)

  15. Applying semantic web services to enterprise web

    OpenAIRE

    Hu, Y; Yang, Q P; Sun, X; Wei, P

    2008-01-01

    Enterprise Web provides a convenient, extendable, integrated platform for information sharing and knowledge management. However, it still has many drawbacks due to complexity and increasing information glut, as well as the heterogeneity of the information processed. Research in the field of Semantic Web Services has shown the possibility of adding higher level of semantic functionality onto the top of current Enterprise Web, enhancing usability and usefulness of resource, enabling decision su...

  16. WebVR: an interactive web browser for virtual environments

    Science.gov (United States)

    Barsoum, Emad; Kuester, Falko

    2005-03-01

    The pervasive nature of web-based content has lead to the development of applications and user interfaces that port between a broad range of operating systems and databases, while providing intuitive access to static and time-varying information. However, the integration of this vast resource into virtual environments has remained elusive. In this paper we present an implementation of a 3D Web Browser (WebVR) that enables the user to search the internet for arbitrary information and to seamlessly augment this information into virtual environments. WebVR provides access to the standard data input and query mechanisms offered by conventional web browsers, with the difference that it generates active texture-skins of the web contents that can be mapped onto arbitrary surfaces within the environment. Once mapped, the corresponding texture functions as a fully integrated web-browser that will respond to traditional events such as the selection of links or text input. As a result, any surface within the environment can be turned into a web-enabled resource that provides access to user-definable data. In order to leverage from the continuous advancement of browser technology and to support both static as well as streamed content, WebVR uses ActiveX controls to extract the desired texture skin from industry strength browsers, providing a unique mechanism for data fusion and extensibility.

  17. FatalCapnocyfophaga septicaemia

    African Journals Online (AJOL)

    Constipation. an~ rectal diseases. NY Med J 1897; ... 5. Southwort~ TS. The causes and treatment of habitual constipation in infancy. ... Operation for chronic obstruction produced by .... unchanged. The central venous pressure was 10 mmHg, ... superficial ulcer was present in the prepyloric posterior wall of the stomach.

  18. Download this PDF file

    African Journals Online (AJOL)

    reconstruction is the most preferred method following distal gastrectomy for Type I pyloric stricture.1. Conventionally, the Billroth I reconstruction is done by carrying out a limited resection of pre-pyloric stricture with the pylorus followed by gastroduodenal hand-sewn anastomosis. Although staplers have widely replaced.

  19. Designing Effective Web Forms for Older Web Users

    Science.gov (United States)

    Li, Hui; Rau, Pei-Luen Patrick; Fujimura, Kaori; Gao, Qin; Wang, Lin

    2012-01-01

    This research aims to provide insight for web form design for older users. The effects of task complexity and information structure of web forms on older users' performance were examined. Forty-eight older participants with abundant computer and web experience were recruited. The results showed significant differences in task time and error rate…

  20. Accuracy of a rapid 10-minute carbon-14 urea breath test for the diagnosis of Helicobacter pylori-associated peptic ulcer disease

    Energy Technology Data Exchange (ETDEWEB)

    Chiahung, Kao [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Nuclear Medicine; Shyhjen, Wang [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Nuclear Medicine; Chungyuan, Hsu [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Nuclear Medicine; Wanyu, Lin [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Nuclear Medicine; Chihkua, Huang [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Gastroenterology; Granhum, Chen [Taichung Veterans General Hospital (Taiwan, Province of China). Dept. of Gastroenterology

    1993-08-01

    Urease in the human gastric mucosa is a marker for infection with Helicobacter pylori (HP), an organism which is associated with peptic ulcer disease. To detect gastric urease, we examined 184 patients (144 males, 40 females; mean age: 49.8[+-]15.6 years) with suspected peptic ulcer disease. Fasting patients were given orally 5 [mu]Ci of carbon-14 labelled urea. For each patient only one breath sample was collected in hyamine at 10 min. The amount of [sup 14]C collected at 10 min was expressed as follows: (DPM/mmol CO[sub 2] collected)/(DPM administered)x100xbody weight (kg). The presence of HP colonization was determined by examination of multiple endoscopic prepyloric antral biopsy specimens subjected to culture or a rapid urease test. For the purpose of this study, HP-positive patients were defined as those with characteristic bacteria as indicated by a positive result of either the culture or the rapid urease test; HP-negative patients were defined as those with negative findings on both the culture and the rapid urease test. Of the 184 cases, 99 (53.8%) were positive for HP infection, and 85 (46.2%), negative. The sensitivity and specificity of the rapid 10 min [sup 14]C-urea breath test for the diagnosis of HP-associated peptic ulcer disease were evaluated by a receiver operating characteristic (ROC) curve with a variable cut-off value from 1.5 to 4.5. When a cut-off value of 1.5 was selected, the sensitivity was 100% and the specificity, 83.5%; when a cut-off value of 4.5 was selected, the sensitivity was 54.5% and the specificity, 97.6%. (orig.)

  1. Accuracy of a rapid 10-minute carbon-14 urea breath test for the diagnosis of Helicobacter pylori-associated peptic ulcer disease

    International Nuclear Information System (INIS)

    Kao Chiahung; Wang Shyhjen; Hsu Chungyuan; Lin Wanyu; Huang Chihkua; Chen Granhum

    1993-01-01

    Urease in the human gastric mucosa is a marker for infection with Helicobacter pylori (HP), an organism which is associated with peptic ulcer disease. To detect gastric urease, we examined 184 patients (144 males, 40 females; mean age: 49.8±15.6 years) with suspected peptic ulcer disease. Fasting patients were given orally 5 μCi of carbon-14 labelled urea. For each patient only one breath sample was collected in hyamine at 10 min. The amount of 14 C collected at 10 min was expressed as follows: [(DPM/mmol CO 2 collected)/(DPM administered)]x100xbody weight (kg). The presence of HP colonization was determined by examination of multiple endoscopic prepyloric antral biopsy specimens subjected to culture or a rapid urease test. For the purpose of this study, HP-positive patients were defined as those with characteristic bacteria as indicated by a positive result of either the culture or the rapid urease test; HP-negative patients were defined as those with negative findings on both the culture and the rapid urease test. Of the 184 cases, 99 (53.8%) were positive for HP infection, and 85 (46.2%), negative. The sensitivity and specificity of the rapid 10 min 14 C-urea breath test for the diagnosis of HP-associated peptic ulcer disease were evaluated by a receiver operating characteristic (ROC) curve with a variable cut-off value from 1.5 to 4.5. When a cut-off value of 1.5 was selected, the sensitivity was 100% and the specificity, 83.5%; when a cut-off value of 4.5 was selected, the sensitivity was 54.5% and the specificity, 97.6%. (orig.)

  2. 75 FR 27986 - Electronic Filing System-Web (EFS-Web) Contingency Option

    Science.gov (United States)

    2010-05-19

    ...] Electronic Filing System--Web (EFS-Web) Contingency Option AGENCY: United States Patent and Trademark Office... contingency option when the primary portal to EFS-Web has an unscheduled outage. Previously, the entire EFS-Web system is not available to the users during such an outage. The contingency option in EFS-Web will...

  3. Geospatial semantic web

    CERN Document Server

    Zhang, Chuanrong; Li, Weidong

    2015-01-01

    This book covers key issues related to Geospatial Semantic Web, including geospatial web services for spatial data interoperability; geospatial ontology for semantic interoperability; ontology creation, sharing, and integration; querying knowledge and information from heterogeneous data source; interfaces for Geospatial Semantic Web, VGI (Volunteered Geographic Information) and Geospatial Semantic Web; challenges of Geospatial Semantic Web; and development of Geospatial Semantic Web applications. This book also describes state-of-the-art technologies that attempt to solve these problems such as WFS, WMS, RDF, OWL, and GeoSPARQL, and demonstrates how to use the Geospatial Semantic Web technologies to solve practical real-world problems such as spatial data interoperability.

  4. 3D Web-based HMI with WebGL Rendering Performance

    Directory of Open Access Journals (Sweden)

    Muennoi Atitayaporn

    2016-01-01

    Full Text Available An HMI, or Human-Machine Interface, is a software allowing users to communicate with a machine or automation system. It usually serves as a display section in SCADA (Supervisory Control and Data Acquisition system for device monitoring and control. In this papper, a 3D Web-based HMI with WebGL (Web-based Graphics Library rendering performance is presented. The main purpose of this work is to attempt to reduce the limitations of traditional 3D web HMI using the advantage of WebGL. To evaluate the performance, frame rate and frame time metrics were used. The results showed 3D Web-based HMI can maintain the frame rate 60FPS for #cube=0.5K/0.8K, 30FPS for #cube=1.1K/1.6K when it was run on Internet Explorer and Chrome respectively. Moreover, the study found that 3D Web-based HMI using WebGL contains similar frame time in each frame even though the numbers of cubes are up to 5K. This indicated stuttering incurred less in the proposed 3D Web-based HMI compared to the chosen commercial HMI product.

  5. 07051 Abstracts Collection -- Programming Paradigms for the Web: Web Programming and Web Services

    OpenAIRE

    Hull, Richard; Thiemann, Peter; Wadler, Philip

    2007-01-01

    From 28.01. to 02.02.2007, the Dagstuhl Seminar 07051 ``Programming Paradigms for the Web: Web Programming and Web Services'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The firs...

  6. Flow Webs: Mechanism and Architecture for the Implementation of Sensor Webs

    Science.gov (United States)

    Gorlick, M. M.; Peng, G. S.; Gasster, S. D.; McAtee, M. D.

    2006-12-01

    The sensor web is a distributed, federated infrastructure much like its predecessors, the internet and the world wide web. It will be a federation of many sensor webs, large and small, under many distinct spans of control, that loosely cooperates and share information for many purposes. Realistically, it will grow piecemeal as distinct, individual systems are developed and deployed, some expressly built for a sensor web while many others were created for other purposes. Therefore, the architecture of the sensor web is of fundamental import and architectural strictures that inhibit innovation, experimentation, sharing or scaling may prove fatal. Drawing upon the architectural lessons of the world wide web, we offer a novel system architecture, the flow web, that elevates flows, sequences of messages over a domain of interest and constrained in both time and space, to a position of primacy as a dynamic, real-time, medium of information exchange for computational services. The flow web captures; in a single, uniform architectural style; the conflicting demands of the sensor web including dynamic adaptations to changing conditions, ease of experimentation, rapid recovery from the failures of sensors and models, automated command and control, incremental development and deployment, and integration at multiple levels—in many cases, at different times. Our conception of sensor webs—dynamic amalgamations of sensor webs each constructed within a flow web infrastructure—holds substantial promise for earth science missions in general, and of weather, air quality, and disaster management in particular. Flow webs, are by philosophy, design and implementation a dynamic infrastructure that permits massive adaptation in real-time. Flows may be attached to and detached from services at will, even while information is in transit through the flow. This concept, flow mobility, permits dynamic integration of earth science products and modeling resources in response to real

  7. The Semantic Web: opportunities and challenges for next-generation Web applications

    Directory of Open Access Journals (Sweden)

    2002-01-01

    Full Text Available Recently there has been a growing interest in the investigation and development of the next generation web - the Semantic Web. While most of the current forms of web content are designed to be presented to humans, but are barely understandable by computers, the content of the Semantic Web is structured in a semantic way so that it is meaningful to computers as well as to humans. In this paper, we report a survey of recent research on the Semantic Web. In particular, we present the opportunities that this revolution will bring to us: web-services, agent-based distributed computing, semantics-based web search engines, and semantics-based digital libraries. We also discuss the technical and cultural challenges of realizing the Semantic Web: the development of ontologies, formal semantics of Semantic Web languages, and trust and proof models. We hope that this will shed some light on the direction of future work on this field.

  8. Working with WebQuests: Making the Web Accessible to Students with Disabilities.

    Science.gov (United States)

    Kelly, Rebecca

    2000-01-01

    This article describes how students with disabilities in regular classes are using the WebQuest lesson format to access the Internet. It explains essential WebQuest principles, creating a draft Web page, and WebQuest components. It offers an example of a WebQuest about salvaging the sunken ships, Titanic and Lusitania. A WebQuest planning form is…

  9. WebGIS based on semantic grid model and web services

    Science.gov (United States)

    Zhang, WangFei; Yue, CaiRong; Gao, JianGuo

    2009-10-01

    As the combination point of the network technology and GIS technology, WebGIS has got the fast development in recent years. With the restriction of Web and the characteristics of GIS, traditional WebGIS has some prominent problems existing in development. For example, it can't accomplish the interoperability of heterogeneous spatial databases; it can't accomplish the data access of cross-platform. With the appearance of Web Service and Grid technology, there appeared great change in field of WebGIS. Web Service provided an interface which can give information of different site the ability of data sharing and inter communication. The goal of Grid technology was to make the internet to a large and super computer, with this computer we can efficiently implement the overall sharing of computing resources, storage resource, data resource, information resource, knowledge resources and experts resources. But to WebGIS, we only implement the physically connection of data and information and these is far from the enough. Because of the different understanding of the world, following different professional regulations, different policies and different habits, the experts in different field will get different end when they observed the same geographic phenomenon and the semantic heterogeneity produced. Since these there are large differences to the same concept in different field. If we use the WebGIS without considering of the semantic heterogeneity, we will answer the questions users proposed wrongly or we can't answer the questions users proposed. To solve this problem, this paper put forward and experienced an effective method of combing semantic grid and Web Services technology to develop WebGIS. In this paper, we studied the method to construct ontology and the method to combine Grid technology and Web Services and with the detailed analysis of computing characteristics and application model in the distribution of data, we designed the WebGIS query system driven by

  10. Cytoplasmic movement profiles of mouse surrounding nucleolus and not-surrounding nucleolus antral oocytes during meiotic resumption.

    Science.gov (United States)

    Bui, Thi Thu Hien; Belli, Martina; Fassina, Lorenzo; Vigone, Giulia; Merico, Valeria; Garagna, Silvia; Zuccotti, Maurizio

    2017-05-01

    Full-grown mouse antral oocytes are classified as surrounding nucleolus (SN) or not-surrounding nucleolus (NSN), depending on the respective presence or absence of a ring of Hoechst-positive chromatin surrounding the nucleolus. In culture, both types of oocytes resume meiosis and reach the metaphase II (MII) stage, but following insemination, NSN oocytes arrest at the two-cell stage whereas SN oocytes may develop to term. By coupling time-lapse bright-field microscopy with image analysis based on particle image velocimetry, we provide the first systematic measure of the changes to the cytoplasmic movement velocity (CMV) occurring during the germinal vesicle-to-MII (GV-to-MII) transition of these two types of oocytes. Compared to SN oocytes, NSN oocytes display a delayed GV-to-MII transition, which can be mostly explained by retarded germinal vesicle break down and first polar body extrusion. SN and NSN oocytes also exhibit significantly different CMV profiles at four main time-lapse intervals, although this difference was not predictive of SN or NSN oocyte origin because of the high variability in CMV. When CMV profile was analyzed through a trained artificial neural network, however, each single SN or NSN oocyte was blindly identified with a probability of 92.2% and 88.7%, respectively. Thus, the CMV profile recorded during meiotic resumption may be exploited as a cytological signature for the non-invasive assessment of the oocyte developmental potential, and could be informative for the analysis of the GV-to-MII transition of oocytes of other species. © 2017 Wiley Periodicals, Inc.

  11. Web Project Management

    OpenAIRE

    Suralkar, Sunita; Joshi, Nilambari; Meshram, B B

    2013-01-01

    This paper describes about the need for Web project management, fundamentals of project management for web projects: what it is, why projects go wrong, and what's different about web projects. We also discuss Cost Estimation Techniques based on Size Metrics. Though Web project development is similar to traditional software development applications, the special characteristics of Web Application development requires adaption of many software engineering approaches or even development of comple...

  12. Promoting Teachers' Positive Attitude towards Web Use: A Study in Web Site Development

    Science.gov (United States)

    Akpinar, Yavuz; Bayramoglu, Yusuf

    2008-01-01

    The purpose of the study was to examine effects of a compact training for developing web sites on teachers' web attitude, as composed of: web self efficacy, perceived web enjoyment, perceived web usefulness and behavioral intention to use the web. To measure the related constructs, the Web Attitude Scale was adapted into Turkish and tested with a…

  13. Web wisdom how to evaluate and create information quality on the Web

    CERN Document Server

    Alexander, Janet E

    1999-01-01

    Web Wisdom is an essential reference for anyone needing to evaluate or establish information quality on the World Wide Web. The book includes easy to use checklists for step-by-step quality evaluations of virtually any Web page. The checklists can also be used by Web authors to help them ensure quality information on their pages. In addition, Web Wisdom addresses other important issues, such as understanding the ways that advertising and sponsorship may affect the quality of Web information. It features: * a detailed discussion of the items involved in evaluating Web information; * checklists

  14. Professional WebGL Programming Developing 3D Graphics for the Web

    CERN Document Server

    Anyuru, Andreas

    2012-01-01

    Everything you need to know about developing hardware-accelerated 3D graphics with WebGL! As the newest technology for creating 3D graphics on the web, in both games, applications, and on regular websites, WebGL gives web developers the capability to produce eye-popping graphics. This book teaches you how to use WebGL to create stunning cross-platform apps. The book features several detailed examples that show you how to develop 3D graphics with WebGL, including explanations of code snippets that help you understand the why behind the how. You will also develop a stronger understanding of W

  15. WebCom: A Model for Understanding Web Site Communication

    DEFF Research Database (Denmark)

    Godsk, Mikkel; Petersen, Anja Bechmann

    2008-01-01

    of the approaches' strengths. Furthermore, it is discussed and shortly demonstrated how WebCom can be used for analytical and design purposes with YouTube as an example. The chapter concludes that WebCom is able to serve as a theoretically-based model for understanding complex Web site communication situations...

  16. SELECTION OF ONTOLOGY FOR WEB SERVICE DESCRIPTION LANGUAGE TO ONTOLOGY WEB LANGUAGE CONVERSION

    OpenAIRE

    J. Mannar Mannan; M. Sundarambal; S. Raghul

    2014-01-01

    Semantic web is to extend the current human readable web to encoding some of the semantic of resources in a machine processing form. As a Semantic web component, Semantic Web Services (SWS) uses a mark-up that makes the data into detailed and sophisticated machine readable way. One such language is Ontology Web Language (OWL). Existing conventional web service annotation can be changed to semantic web service by mapping Web Service Description Language (WSDL) with the semantic annotation of O...

  17. Virtual Web Services

    OpenAIRE

    Rykowski, Jarogniew

    2007-01-01

    In this paper we propose an application of software agents to provide Virtual Web Services. A Virtual Web Service is a linked collection of several real and/or virtual Web Services, and public and private agents, accessed by the user in the same way as a single real Web Service. A Virtual Web Service allows unrestricted comparison, information merging, pipelining, etc., of data coming from different sources and in different forms. Detailed architecture and functionality of a single Virtual We...

  18. WebScore: An Effective Page Scoring Approach for Uncertain Web Social Networks

    Directory of Open Access Journals (Sweden)

    Shaojie Qiao

    2011-10-01

    Full Text Available To effectively score pages with uncertainty in web social networks, we first proposed a new concept called transition probability matrix and formally defined the uncertainty in web social networks. Second, we proposed a hybrid page scoring algorithm, called WebScore, based on the PageRank algorithm and three centrality measures including degree, betweenness, and closeness. Particularly,WebScore takes into a full consideration of the uncertainty of web social networks by computing the transition probability from one page to another. The basic idea ofWebScore is to: (1 integrate uncertainty into PageRank in order to accurately rank pages, and (2 apply the centrality measures to calculate the importance of pages in web social networks. In order to verify the performance of WebScore, we developed a web social network analysis system which can partition web pages into distinct groups and score them in an effective fashion. Finally, we conducted extensive experiments on real data and the results show that WebScore is effective at scoring uncertain pages with less time deficiency than PageRank and centrality measures based page scoring algorithms.

  19. Responsive web design workflow

    OpenAIRE

    LAAK, TIMO

    2013-01-01

    Responsive Web Design Workflow is a literature review about Responsive Web Design, a web standards based modern web design paradigm. The goals of this research were to define what responsive web design is, determine its importance in building modern websites and describe a workflow for responsive web design projects. Responsive web design is a paradigm to create adaptive websites, which respond to the properties of the media that is used to render them. The three key elements of responsi...

  20. Web services foundations

    CERN Document Server

    Bouguettaya, Athman; Daniel, Florian

    2013-01-01

    Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet.Web Services Foundations is the first installment of a two-book collection coverin

  1. Semantic web for dummies

    CERN Document Server

    Pollock, Jeffrey T

    2009-01-01

    Semantic Web technology is already changing how we interact with data on the Web. By connecting random information on the Internet in new ways, Web 3.0, as it is sometimes called, represents an exciting online evolution. Whether you're a consumer doing research online, a business owner who wants to offer your customers the most useful Web site, or an IT manager eager to understand Semantic Web solutions, Semantic Web For Dummies is the place to start! It will help you:Know how the typical Internet user will recognize the effects of the Semantic WebExplore all the benefits the data Web offers t

  2. Building web information systems using web services

    NARCIS (Netherlands)

    Frasincar, F.; Houben, G.J.P.M.; Barna, P.; Vasilecas, O.; Eder, J.; Caplinskas, A.

    2006-01-01

    Hera is a model-driven methodology for designing Web information systems. In the past a CASE tool for the Hera methodology was implemented. This software had different components that together form one centralized application. In this paper, we present a distributed Web service-oriented architecture

  3. Development and Evaluation of an Interactive WebQuest Environment: "Web Macerasi"

    Science.gov (United States)

    Gulbahar, Yasemin; Madran, R. Orcun; Kalelioglu, Filiz

    2010-01-01

    This study was conducted to develop a web-based interactive system, Web Macerasi, for teaching-learning and evaluation purposes, and to find out the possible effects of this system. The study has two stages. In the first stage, a WebQuest site was designed as an interactive system in which various Internet and web technologies were used for…

  4. Web Analytics: A Picture of the Academic Library Web Site User

    Science.gov (United States)

    Black, Elizabeth L.

    2009-01-01

    This article describes the usefulness of Web analytics for understanding the users of an academic library Web site. Using a case study, the analysis describes how Web analytics can answer questions about Web site user behavior, including when visitors come, the duration of the visit, how they get there, the technology they use, and the most…

  5. Web Mining and Social Networking

    DEFF Research Database (Denmark)

    Xu, Guandong; Zhang, Yanchun; Li, Lin

    This book examines the techniques and applications involved in the Web Mining, Web Personalization and Recommendation and Web Community Analysis domains, including a detailed presentation of the principles, developed algorithms, and systems of the research in these areas. The applications of web ...... sense of individuals or communities. The volume will benefit both academic and industry communities interested in the techniques and applications of web search, web data management, web mining and web knowledge discovery, as well as web community and social network analysis.......This book examines the techniques and applications involved in the Web Mining, Web Personalization and Recommendation and Web Community Analysis domains, including a detailed presentation of the principles, developed algorithms, and systems of the research in these areas. The applications of web...... mining, and the issue of how to incorporate web mining into web personalization and recommendation systems are also reviewed. Additionally, the volume explores web community mining and analysis to find the structural, organizational and temporal developments of web communities and reveal the societal...

  6. Web API Fragility : How Robust is Your Web API Client

    NARCIS (Netherlands)

    Espinha, T.; Zaidman, A.; Gross, H.G.

    2014-01-01

    Web APIs provide a systematic and extensible approach for application-to-application interaction. A large number of mobile applications makes use of web APIs to integrate services into apps. Each Web API’s evolution pace is determined by their respective developer and mobile application developers

  7. Sounds of Web Advertising

    DEFF Research Database (Denmark)

    Jessen, Iben Bredahl; Graakjær, Nicolai Jørgensgaard

    2010-01-01

    Sound seems to be a neglected issue in the study of web ads. Web advertising is predominantly regarded as visual phenomena–commercial messages, as for instance banner ads that we watch, read, and eventually click on–but only rarely as something that we listen to. The present chapter presents...... an overview of the auditory dimensions in web advertising: Which kinds of sounds do we hear in web ads? What are the conditions and functions of sound in web ads? Moreover, the chapter proposes a theoretical framework in order to analyse the communicative functions of sound in web advertising. The main...... argument is that an understanding of the auditory dimensions in web advertising must include a reflection on the hypertextual settings of the web ad as well as a perspective on how users engage with web content....

  8. Web analytics tools and web metrics tools: An overview and comparative analysis

    Directory of Open Access Journals (Sweden)

    Ivan Bekavac

    2015-10-01

    Full Text Available The aim of the paper is to compare and analyze the impact of web analytics tools for measuring the performance of a business model. Accordingly, an overview of web analytics and web metrics tools is given, including their characteristics, main functionalities and available types. The data acquisition approaches and proper choice of web tools for particular business models are also reviewed. The research is divided in two sections. First, a qualitative focus is placed on reviewing web analytics tools to exploring their functionalities and ability to be integrated into the respective business model. Web analytics tools support the business analyst’s efforts in obtaining useful and relevant insights into market dynamics. Thus, generally speaking, selecting a web analytics and web metrics tool should be based on an investigative approach, not a random decision. The second section is a quantitative focus shifting from theory to an empirical approach, and which subsequently presents output data resulting from a study based on perceived user satisfaction of web analytics tools. The empirical study was carried out on employees from 200 Croatian firms from either an either IT or marketing branch. The paper contributes to highlighting the support for management that available web analytics and web metrics tools available on the market have to offer, and based on the growing needs of understanding and predicting global market trends.

  9. Web server attack analyzer

    OpenAIRE

    Mižišin, Michal

    2013-01-01

    Web server attack analyzer - Abstract The goal of this work was to create prototype of analyzer of injection flaws attacks on web server. Proposed solution combines capabilities of web application firewall and web server log analyzer. Analysis is based on configurable signatures defined by regular expressions. This paper begins with summary of web attacks, followed by detection techniques analysis on web servers, description and justification of selected implementation. In the end are charact...

  10. Engineering Web Applications

    DEFF Research Database (Denmark)

    Casteleyn, Sven; Daniel, Florian; Dolog, Peter

    Nowadays, Web applications are almost omnipresent. The Web has become a platform not only for information delivery, but also for eCommerce systems, social networks, mobile services, and distributed learning environments. Engineering Web applications involves many intrinsic challenges due...... to their distributed nature, content orientation, and the requirement to make them available to a wide spectrum of users who are unknown in advance. The authors discuss these challenges in the context of well-established engineering processes, covering the whole product lifecycle from requirements engineering through...... design and implementation to deployment and maintenance. They stress the importance of models in Web application development, and they compare well-known Web-specific development processes like WebML, WSDM and OOHDM to traditional software development approaches like the waterfall model and the spiral...

  11. Web Application Vulnerabilities

    OpenAIRE

    Yadav, Bhanu

    2014-01-01

    Web application security has been a major issue in information technology since the evolvement of dynamic web application. The main objective of this project was to carry out a detailed study on the top three web application vulnerabilities such as injection, cross site scripting, broken authentication and session management, present the situation where an application can be vulnerable to these web threats and finally provide preventative measures against them. ...

  12. WebMGA: a customizable web server for fast metagenomic sequence analysis.

    Science.gov (United States)

    Wu, Sitao; Zhu, Zhengwei; Fu, Liming; Niu, Beifang; Li, Weizhong

    2011-09-07

    The new field of metagenomics studies microorganism communities by culture-independent sequencing. With the advances in next-generation sequencing techniques, researchers are facing tremendous challenges in metagenomic data analysis due to huge quantity and high complexity of sequence data. Analyzing large datasets is extremely time-consuming; also metagenomic annotation involves a wide range of computational tools, which are difficult to be installed and maintained by common users. The tools provided by the few available web servers are also limited and have various constraints such as login requirement, long waiting time, inability to configure pipelines etc. We developed WebMGA, a customizable web server for fast metagenomic analysis. WebMGA includes over 20 commonly used tools such as ORF calling, sequence clustering, quality control of raw reads, removal of sequencing artifacts and contaminations, taxonomic analysis, functional annotation etc. WebMGA provides users with rapid metagenomic data analysis using fast and effective tools, which have been implemented to run in parallel on our local computer cluster. Users can access WebMGA through web browsers or programming scripts to perform individual analysis or to configure and run customized pipelines. WebMGA is freely available at http://weizhongli-lab.org/metagenomic-analysis. WebMGA offers to researchers many fast and unique tools and great flexibility for complex metagenomic data analysis.

  13. WebMGA: a customizable web server for fast metagenomic sequence analysis

    Directory of Open Access Journals (Sweden)

    Niu Beifang

    2011-09-01

    Full Text Available Abstract Background The new field of metagenomics studies microorganism communities by culture-independent sequencing. With the advances in next-generation sequencing techniques, researchers are facing tremendous challenges in metagenomic data analysis due to huge quantity and high complexity of sequence data. Analyzing large datasets is extremely time-consuming; also metagenomic annotation involves a wide range of computational tools, which are difficult to be installed and maintained by common users. The tools provided by the few available web servers are also limited and have various constraints such as login requirement, long waiting time, inability to configure pipelines etc. Results We developed WebMGA, a customizable web server for fast metagenomic analysis. WebMGA includes over 20 commonly used tools such as ORF calling, sequence clustering, quality control of raw reads, removal of sequencing artifacts and contaminations, taxonomic analysis, functional annotation etc. WebMGA provides users with rapid metagenomic data analysis using fast and effective tools, which have been implemented to run in parallel on our local computer cluster. Users can access WebMGA through web browsers or programming scripts to perform individual analysis or to configure and run customized pipelines. WebMGA is freely available at http://weizhongli-lab.org/metagenomic-analysis. Conclusions WebMGA offers to researchers many fast and unique tools and great flexibility for complex metagenomic data analysis.

  14. Web party effect: a cocktail party effect in the web environment.

    Science.gov (United States)

    Rigutti, Sara; Fantoni, Carlo; Gerbino, Walter

    2015-01-01

    In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all) web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots) on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search). Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment): users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others.

  15. WEB LOG EXPLORER – CONTROL OF MULTIDIMENSIONAL DYNAMICS OF WEB PAGES

    Directory of Open Access Journals (Sweden)

    Mislav Šimunić

    2012-07-01

    Full Text Available Demand markets dictate and pose increasingly more requirements to the supplymarket that are not easily satisfied. The supply market presenting its web pages to thedemand market should find the best and quickest ways to respond promptly to the changesdictated by the demand market. The question is how to do that in the most efficient andquickest way. The data on the usage of web pages on a specific web site are recorded in alog file. The data in a log file are stochastic and unordered and require systematicmonitoring, categorization, analyses, and weighing. From the data processed in this way, itis necessary to single out and sort the data by their importance that would be a basis for acontinuous generation of dynamics/changes to the web site pages in line with the criterionchosen. To perform those tasks successfully, a new software solution is required. For thatpurpose, the authors have developed the first version of the WLE (WebLogExplorersoftware solution, which is actually realization of web page multidimensionality and theweb site as a whole. The WebLogExplorer enables statistical and semantic analysis of a logfile and on the basis thereof, multidimensional control of the web page dynamics. Theexperimental part of the work was done within the web site of HTZ (Croatian NationalTourist Board being the main portal of the global tourist supply in the Republic of Croatia(on average, daily "log" consists of c. 600,000 sets, average size of log file is 127 Mb, andc. 7000-8000 daily visitors on the web site.

  16. Web-Based Course Management and Web Services

    Science.gov (United States)

    Mandal, Chittaranjan; Sinha, Vijay Luxmi; Reade, Christopher M. P.

    2004-01-01

    The architecture of a web-based course management tool that has been developed at IIT [Indian Institute of Technology], Kharagpur and which manages the submission of assignments is discussed. Both the distributed architecture used for data storage and the client-server architecture supporting the web interface are described. Further developments…

  17. Web-page Prediction for Domain Specific Web-search using Boolean Bit Mask

    OpenAIRE

    Sinha, Sukanta; Duttagupta, Rana; Mukhopadhyay, Debajyoti

    2012-01-01

    Search Engine is a Web-page retrieval tool. Nowadays Web searchers utilize their time using an efficient search engine. To improve the performance of the search engine, we are introducing a unique mechanism which will give Web searchers more prominent search results. In this paper, we are going to discuss a domain specific Web search prototype which will generate the predicted Web-page list for user given search string using Boolean bit mask.

  18. Web X-Ray: Developing and Adopting Web Best Practices in Enterprises

    Directory of Open Access Journals (Sweden)

    Reinaldo Ferreira

    2016-12-01

    Full Text Available The adoption of Semantic Web technologies constitutes a promising approach to data structuring and integration, both for public and private usage. While these technologies have been around for some time, their adoption is behind overall expectations, particularly in the case of Enterprises. Having that in mind, we developed a Semantic Web Implementation Model that measures and facilitates the implementation of the technology. The advantages of using the model proposed are two-fold: the model serves as a guide for driving the implementation of the Semantic Web as well as it helps to evaluate the impact of the introduction of the technology. The model was adopted by 19 enterprises in an Action Research intervention of one year with promising results: according to the model's scale, in average, all enterprises evolved from a 6% evaluation to 46% during that period. Furthermore, practical implementation recommendations, a typical consulting tool, were developed and adopted during the project by all enterprises, providing important guidelines for the identification of a development path that may be adopted on a larger scale. Meanwhile, the project also outlined that most enterprises were interested in an even broader scope of the Implementation Model and the ambition of a "All Web Technologies" approach arose. One model that could embrace the observable overlapping of different Web generations, namely the Web of Documents, the Social Web, the Web of Data and, ultimately, the Web of Context. One model that could combine the evaluation and guidance for all enterprises to follow. That's the goal of the undergoing "Project Web X-ray" that aims to involve 200 enterprises in the adoption of best practices that may lead to their business development based on Web technologies. This paper presents a case of how Action Research promoted the simultaneous advancement of academic research and enterprise development and introduces the framework and opportunities

  19. Global Web Accessibility Analysis of National Government Portals and Ministry Web Sites

    DEFF Research Database (Denmark)

    Goodwin, Morten; Susar, Deniz; Nietzio, Annika

    2011-01-01

    Equal access to public information and services for all is an essential part of the United Nations (UN) Declaration of Human Rights. Today, the Web plays an important role in providing information and services to citizens. Unfortunately, many government Web sites are poorly designed and have...... accessibility barriers that prevent people with disabilities from using them. This article combines current Web accessibility benchmarking methodologies with a sound strategy for comparing Web accessibility among countries and continents. Furthermore, the article presents the first global analysis of the Web...... accessibility of 192 United Nation Member States made publically available. The article also identifies common properties of Member States that have accessible and inaccessible Web sites and shows that implementing antidisability discrimination laws is highly beneficial for the accessibility of Web sites, while...

  20. Effect of the FSH receptor single nucleotide polymorphisms (FSHR 307/680) on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles

    DEFF Research Database (Denmark)

    Borgbo, Tanni Kjær; Jeppesen, J V; Lindgren, I

    2014-01-01

    ), by evaluating the hormone and gene expression profiles of human small antral follicles collected under physiological conditions in connection with fertility preservation. In total 69 women at various time during the menstrual cycle were included in this study. The intrafollicular hormone content of 179...... was significantly increased, whereas AMH gene expression was significantly reduced for the G/G genotype. In follicles >6 mm, estradiol and CYP19A1 gene expression levels were significantly higher for the G/G genotype. In conclusion, significant changes were observed between the FSHR 307/680 polymorphisms in human......The most pronounced effects of FSH signalling are potentially displayed in the follicle fluid, which acts as a reservoir for FSH-induced granulosa cell (GC) secreted hormones. This study investigates the effects of two common polymorphisms of FSHR, FSHR 307 (rs6165) and FSHR 680 (rs6166...

  1. Writing for the web composing, coding, and constructing web sites

    CERN Document Server

    Applen, JD

    2013-01-01

    Writing for the Web unites theory, technology, and practice to explore writing and hypertext for website creation. It integrates such key topics as XHTML/CSS coding, writing (prose) for the Web, the rhetorical needs of the audience, theories of hypertext, usability and architecture, and the basics of web site design and technology. Presenting information in digestible parts, this text enables students to write and construct realistic and manageable Web sites with a strong theoretical understanding of how online texts communicate to audiences. Key features of the book

  2. The Role of the Web Server in a Capstone Web Application Course

    Science.gov (United States)

    Umapathy, Karthikeyan; Wallace, F. Layne

    2010-01-01

    Web applications have become commonplace in the Information Systems curriculum. Much of the discussion about Web development for capstone courses has centered on the scripting tools. Very little has been discussed about different ways to incorporate the Web server into Web application development courses. In this paper, three different ways of…

  3. Web party effect: a cocktail party effect in the web environment

    Directory of Open Access Journals (Sweden)

    Sara Rigutti

    2015-03-01

    Full Text Available In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search. Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment: users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others.

  4. Web party effect: a cocktail party effect in the web environment

    Science.gov (United States)

    Gerbino, Walter

    2015-01-01

    In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all) web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots) on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search). Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment): users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others. PMID:25802803

  5. Embedded Web Technology: Applying World Wide Web Standards to Embedded Systems

    Science.gov (United States)

    Ponyik, Joseph G.; York, David W.

    2002-01-01

    Embedded Systems have traditionally been developed in a highly customized manner. The user interface hardware and software along with the interface to the embedded system are typically unique to the system for which they are built, resulting in extra cost to the system in terms of development time and maintenance effort. World Wide Web standards have been developed in the passed ten years with the goal of allowing servers and clients to intemperate seamlessly. The client and server systems can consist of differing hardware and software platforms but the World Wide Web standards allow them to interface without knowing about the details of system at the other end of the interface. Embedded Web Technology is the merging of Embedded Systems with the World Wide Web. Embedded Web Technology decreases the cost of developing and maintaining the user interface by allowing the user to interface to the embedded system through a web browser running on a standard personal computer. Embedded Web Technology can also be used to simplify an Embedded System's internal network.

  6. Web service composition: a semantic web and automated planning technique application

    Directory of Open Access Journals (Sweden)

    Jaime Alberto Guzmán Luna

    2008-09-01

    Full Text Available This article proposes applying semantic web and artificial intelligence planning techniques to a web services composition model dealing with problems of ambiguity in web service description and handling incomplete web information. The model uses an OWL-S services and implements a planning technique which handles open world semantics in its reasoning process to resolve these problems. This resulted in a web services composition system incorporating a module for interpreting OWL-S services and converting them into a planning problem in PDDL (a planning module handling incomplete information and an execution service module concurrently interacting with the planner for executing each composition plan service.

  7. Learning from WebQuests

    Science.gov (United States)

    Gaskill, Martonia; McNulty, Anastasia; Brooks, David W.

    2006-04-01

    WebQuests are activities in which students use Web resources to learn about school topics. WebQuests are advocated as constructivist activities and ones generally well regarded by students. Two experiments were conducted in school settings to compare learning using WebQuests versus conventional instruction. Students and teachers both enjoyed WebQuest instruction and spoke highly of it. In one experiment, however, conventional instruction led to significantly greater student learning. In the other, there were no significant differences in the learning outcomes between conventional versus WebQuest-based instruction.

  8. WebEase: Development of a Web-Based Epilepsy Self-Management Intervention

    OpenAIRE

    DiIorio, Colleen; Escoffery, Cam; Yeager, Katherine A.; Koganti, Archana; Reisinger, Elizabeth; Koganti, Archana; McCarty, Frances; Henry, Thomas R.; Robinson, Elise; Kobau, Rosemarie; Price, Patricia

    2008-01-01

    People with epilepsy must adopt many self-management behaviors, especially regarding medication adherence, stress management, and sleep quality. In response to the need for theory-based self-management programs that people with epilepsy can easily access, the WebEase Web site was created and tested for feasibility, acceptability, and usability. This article discusses the theoretical background and developmental phases of WebEase and lessons learned throughout the development process. The WebE...

  9. A Web System Trace Model and Its Application to Web Design

    OpenAIRE

    Kong, Xiaoying; Liu, Li; Lowe, David

    2007-01-01

    Traceability analysis is crucial to the development of web-centric systems, particularly those with frequent system changes, fine-grained evolution and maintenance, and high level of requirements uncertainty. A trace model at the level of the web system architecture is presented in this paper to address the specific challenges of developing web-centric systems. The trace model separates the concerns of different stakeholders in the web development life cycle into viewpoints; and c...

  10. Take control of iWeb

    CERN Document Server

    Sande, Steve

    2009-01-01

    Learn how to make useful, attractive Web sites with iWeb! Apple's iWeb aims to help you build an attractive Web site quickly and easily, but not all of iWeb's features are fully explained. If you want step-by-step instructions and plenty of time-saving tips, Web pro Steve Sande can help. In Take Control of iWeb, Steve walks you through all the steps for building an iWeb site and uploading it to .Mac or to another Web host. You can look over his shoulder as he enhances iWeb's templates with a designer's eye, using tools like masks, reflections, and Instant Alpha.Steve teaches you the best ways

  11. Het WEB leert begrijpen

    CERN Multimedia

    Stroeykens, Steven

    2004-01-01

    The WEB could be much more useful if the computers understood something of information on the Web pages. That explains the goal of the "semantic Web", a project in which takes part, amongst others, Tim Berners Lee, the inventor of the original WEB

  12. WebFTS: File Transfer Web Interface for FTS3

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    WebFTS is a web-delivered file transfer and management solution which allows users to invoke reliable, managed data transfers on distributed infrastructures. The fully open source solution offers a simple graphical interface through which the power of the FTS3 service can be accessed without the installation of any special grid tools. Created following simplicity and efficiency criteria, WebFTS allows the user to access and interact with multiple grid and cloud storage. The “transfer engine” used is FTS3, the service responsible for distributing the majority of LHC data across WLCG infrastructure. This provides WebFTS with reliable, multi-protocol, adaptively optimised data transfers.The talk will focus on the recent development which allows transfers from/to Dropbox and CERNBox (CERN ownCloud deployment)

  13. Web Search Engines

    OpenAIRE

    Rajashekar, TB

    1998-01-01

    The World Wide Web is emerging as an all-in-one information source. Tools for searching Web-based information include search engines, subject directories and meta search tools. We take a look at key features of these tools and suggest practical hints for effective Web searching.

  14. WebSpy: An Architecture for Monitoring Web Server Availability in a Multi-Platform Environment

    Directory of Open Access Journals (Sweden)

    Madhan Mohan Thirukonda

    2002-01-01

    Full Text Available For an electronic business (e-business, customer satisfaction can be the difference between long-term success and short-term failure. Customer satisfaction is highly impacted by Web server availability, as customers expect a Web site to be available twenty-four hours a day and seven days a week. Unfortunately, unscheduled Web server downtime is often beyond the control of the organization. What is needed is an effective means of identifying and recovering from Web server downtime in order to minimize the negative impact on the customer. An automated architecture, called WebSpy, has been developed to notify administration and to take immediate action when Web server downtime is detected. This paper describes the WebSpy architecture and differentiates it from other popular Web monitoring tools. The results of a case study are presented as a means of demonstrating WebSpy's effectiveness in monitoring Web server availability.

  15. Maximum Spanning Tree Model on Personalized Web Based Collaborative Learning in Web 3.0

    OpenAIRE

    Padma, S.; Seshasaayee, Ananthi

    2012-01-01

    Web 3.0 is an evolving extension of the current web environme bnt. Information in web 3.0 can be collaborated and communicated when queried. Web 3.0 architecture provides an excellent learning experience to the students. Web 3.0 is 3D, media centric and semantic. Web based learning has been on high in recent days. Web 3.0 has intelligent agents as tutors to collect and disseminate the answers to the queries by the students. Completely Interactive learner's query determine the customization of...

  16. Web Mining and Social Networking

    CERN Document Server

    Xu, Guandong; Li, Lin

    2011-01-01

    This book examines the techniques and applications involved in the Web Mining, Web Personalization and Recommendation and Web Community Analysis domains, including a detailed presentation of the principles, developed algorithms, and systems of the research in these areas. The applications of web mining, and the issue of how to incorporate web mining into web personalization and recommendation systems are also reviewed. Additionally, the volume explores web community mining and analysis to find the structural, organizational and temporal developments of web communities and reveal the societal s

  17. Semantic Web Primer

    NARCIS (Netherlands)

    Antoniou, Grigoris; Harmelen, Frank van

    2004-01-01

    The development of the Semantic Web, with machine-readable content, has the potential to revolutionize the World Wide Web and its use. A Semantic Web Primer provides an introduction and guide to this still emerging field, describing its key ideas, languages, and technologies. Suitable for use as a

  18. CSAR-web: a web server of contig scaffolding using algebraic rearrangements.

    Science.gov (United States)

    Chen, Kun-Tze; Lu, Chin Lung

    2018-05-04

    CSAR-web is a web-based tool that allows the users to efficiently and accurately scaffold (i.e. order and orient) the contigs of a target draft genome based on a complete or incomplete reference genome from a related organism. It takes as input a target genome in multi-FASTA format and a reference genome in FASTA or multi-FASTA format, depending on whether the reference genome is complete or incomplete, respectively. In addition, it requires the users to choose either 'NUCmer on nucleotides' or 'PROmer on translated amino acids' for CSAR-web to identify conserved genomic markers (i.e. matched sequence regions) between the target and reference genomes, which are used by the rearrangement-based scaffolding algorithm in CSAR-web to order and orient the contigs of the target genome based on the reference genome. In the output page, CSAR-web displays its scaffolding result in a graphical mode (i.e. scalable dotplot) allowing the users to visually validate the correctness of scaffolded contigs and in a tabular mode allowing the users to view the details of scaffolds. CSAR-web is available online at http://genome.cs.nthu.edu.tw/CSAR-web.

  19. Going, going, still there: using the WebCite service to permanently archive cited web pages.

    Science.gov (United States)

    Eysenbach, Gunther; Trudel, Mathieu

    2005-12-30

    Scholars are increasingly citing electronic "web references" which are not preserved in libraries or full text archives. WebCite is a new standard for citing web references. To "webcite" a document involves archiving the cited Web page through www.webcitation.org and citing the WebCite permalink instead of (or in addition to) the unstable live Web page. This journal has amended its "instructions for authors" accordingly, asking authors to archive cited Web pages before submitting a manuscript. Almost 200 other journals are already using the system. We discuss the rationale for WebCite, its technology, and how scholars, editors, and publishers can benefit from the service. Citing scholars initiate an archiving process of all cited Web references, ideally before they submit a manuscript. Authors of online documents and websites which are expected to be cited by others can ensure that their work is permanently available by creating an archived copy using WebCite and providing the citation information including the WebCite link on their Web document(s). Editors should ask their authors to cache all cited Web addresses (Uniform Resource Locators, or URLs) "prospectively" before submitting their manuscripts to their journal. Editors and publishers should also instruct their copyeditors to cache cited Web material if the author has not done so already. Finally, WebCite can process publisher submitted "citing articles" (submitted for example as eXtensible Markup Language [XML] documents) to automatically archive all cited Web pages shortly before or on publication. Finally, WebCite can act as a focussed crawler, caching retrospectively references of already published articles. Copyright issues are addressed by honouring respective Internet standards (robot exclusion files, no-cache and no-archive tags). Long-term preservation is ensured by agreements with libraries and digital preservation organizations. The resulting WebCite Index may also have applications for research

  20. WebGL and web audio software lightweight components for multimedia education

    Science.gov (United States)

    Chang, Xin; Yuksel, Kivanc; Skarbek, Władysław

    2017-08-01

    The paper presents the results of our recent work on development of contemporary computing platform DC2 for multimedia education usingWebGL andWeb Audio { the W3C standards. Using literate programming paradigm the WEBSA educational tools were developed. It offers for a user (student), the access to expandable collection of WEBGL Shaders and web Audio scripts. The unique feature of DC2 is the option of literate programming, offered for both, the author and the reader in order to improve interactivity to lightweightWebGL andWeb Audio components. For instance users can define: source audio nodes including synthetic sources, destination audio nodes, and nodes for audio processing such as: sound wave shaping, spectral band filtering, convolution based modification, etc. In case of WebGL beside of classic graphics effects based on mesh and fractal definitions, the novel image processing analysis by shaders is offered like nonlinear filtering, histogram of gradients, and Bayesian classifiers.

  1. Applying Web usage mining for personalizing hyperlinks in Web-based adaptive educational systems

    NARCIS (Netherlands)

    Romero, C.; Ventura, S.; Zafra, A.; Bra, de P.M.E.

    2009-01-01

    Nowadays, the application of Web mining techniques in e-learning and Web-based adaptive educational systems is increasing exponentially. In this paper, we propose an advanced architecture for a personalization system to facilitate Web mining. A specific Web mining tool is developed and a recommender

  2. The Semantic Web Revisited

    OpenAIRE

    Shadbolt, Nigel; Berners-Lee, Tim; Hall, Wendy

    2006-01-01

    The original Scientific American article on the Semantic Web appeared in 2001. It described the evolution of a Web that consisted largely of documents for humans to read to one that included data and information for computers to manipulate. The Semantic Web is a Web of actionable information--information derived from data through a semantic theory for interpreting the symbols.This simple idea, however, remains largely unrealized. Shopbots and auction bots abound on the Web, but these are esse...

  3. Advanced web services

    CERN Document Server

    Bouguettaya, Athman; Daniel, Florian

    2013-01-01

    Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet. This book is the second installment of a two-book collection covering the state-o

  4. Web-sovelluskehityksen tekniikat

    OpenAIRE

    Kettunen, Werner

    2015-01-01

    Web-sovelluskehitykseen käytettäviä tekniikoita, työkaluja ja ohjelmakirjastoja on olemassa useita erilaisia ja niiden lähestymistapa web-sovelluskehitykseen poikkeaa jonkin verran toisistaan. Opinnäytetyössä selvitetään teoriassa ja käytännön esimerkkiprojektin avulla yleisimmin web-sovelluskehityksessä käytettyjä tekniikoita ja kirjastoja. Työssä esimerkkinä luodussa web-sovelluksessa käytettiin Laravel-ohjelmakehystä ja alkuosassa käsiteltyjä työkaluja ja kirjastoja, kuten Bootstrap ja ...

  5. Learning from WebQuests

    Science.gov (United States)

    Gaskill, Martonia; McNulty, Anastasia; Brooks, David W.

    2006-01-01

    WebQuests are activities in which students use Web resources to learn about school topics. WebQuests are advocated as constructivist activities and ones generally well regarded by students. Two experiments were conducted in school settings to compare learning using WebQuests versus conventional instruction. Students and teachers both enjoyed…

  6. Evaluating Web Usability

    Science.gov (United States)

    Snider, Jean; Martin, Florence

    2012-01-01

    Web usability focuses on design elements and processes that make web pages easy to use. A website for college students was evaluated for underutilization. One-on-one testing, focus groups, web analytics, peer university review and marketing focus group and demographic data were utilized to conduct usability evaluation. The results indicated that…

  7. FedWeb Greatest Hits: Presenting the New Test Collection for Federated Web Search

    NARCIS (Netherlands)

    Demeester, Thomas; Trieschnigg, Rudolf Berend; Zhou, Ke; Nguyen, Dong-Phuong; Hiemstra, Djoerd

    This paper presents 'FedWeb Greatest Hits', a large new test collection for research in web information retrieval. As a combination and extension of the datasets used in the TREC Federated Web Search Track, this collection opens up new research possibilities on federated web search challenges, as

  8. Antral Follicle Count Predicts Natural Menopause in a Population-Based Sample: The CARDIA Women’s Study

    Science.gov (United States)

    Wellons, Melissa F.; Bates, Gordon Wright; Schreiner, Pamela J.; Siscovick, David S.; Sternfeld, Barbara; Lewis, Cora E.

    2013-01-01

    Objective The timing of menopause is associated with multiple chronic diseases. Tools to predict this milestone have relevance for clinical and research purposes. Among infertile women, a positive relationship exists between antral follicle count (AFC) and response to controlled ovarian hyperstimulation, a marker of ovarian reserve. However, a relationship between AFC and menopause that is age-independent has not been demonstrated. Thus, our objective was to evaluate the relationship between AFC measured in women at ages 34–49 and incident natural menopause over 7-years of follow-up. Methods The Coronary Artery Risk Development in Young Adults (CARDIA) study is a longitudinal community-based study (Chicago, Illinois; Birmingham, Alabama; Minneapolis, Minnesota; and Oakland, California) begun in 1985–1986. In 2002–03, the CARDIA Women’s Study measured FSH levels and performed a transvaginal ultrasound protocol that included AFC (2mm–10mm follicles on both ovaries). Incident natural menopause was assessed by survey in 2005–06 and 2009–10. Results In our sample (n=456), median AFC and FSH were 5 (IQR 2–9) and 7.8 mIU/mL (IQR 5.6–11.0), respectively, at a mean age of 42 (range 34–49) in 2002–03. 101 women reported natural menopause by 2009–10. In Cox models, current smoking, stable menses, FSH>13, and AFC ≤4 were independently associated with incident natural menopause. Compared to AFC >4, those with AFC ≤4 were nearly twice as likely to have undergone menopause over 7-years of follow-up (HR 1.89, 95% CI 1.19–3.02) after adjustment for covariates. Conclusion AFC is independently associated with natural menopause over 7-years of follow-up after controlling for other markers of ovarian aging. PMID:23422869

  9. Evidence for alternative pathways of granulosa cell death in healthy and slightly atretic bovine antral follicles.

    Science.gov (United States)

    Van Wezel, I L; Dharmarajan, A M; Lavranos, T C; Rodgers, R J

    1999-06-01

    Granulosa cell death is an early feature of atresia; however, there are many apparent contradictions in the literature concerning the mode of granulosa cell death. We have therefore examined this process in bovine healthy and atretic antral follicles, using a variety of established techniques. Light and electron microscopic observations indicated the presence of pyknotic or shrunken nuclei in both the membrana granulosa and the antrum. In the membrana granulosa, these nuclei were frequently crescent shaped and uniformly electron dense and were approximately the same size as healthy nuclei, all of which are typical of early apoptosis. However, these nuclei were within the membranes of a healthy granulosa cell, suggesting that phagocytosis by a neighboring granulosa cell is an unusually early event in the apoptotic pathway of granulosa cells. In the membrana granulosa, pyknotic nuclei stained intensely with hematoxylin but weakly with the DNA-intercalating stain propidium iodide. A percentage of these pyknotic nuclei stained by TUNEL (terminal deoxy-UTP nick end-labeling). However, in the antrum, the pyknotic nuclei and larger globules of DNA stained intensely with both hematoxylin and propidium iodide, but were not TUNEL positive. The comet assay of cell death produced a streak tail of randomly nicked DNA, rather than the plume of low mol wt apoptotic DNA. Globules collected from fresh follicular fluid stained intensely with propidium iodide and were shown by PAGE to contain DNA, the majority of which was high mol wt. In conclusion, granulosa cells within the membrana granulosa die by apoptosis, with phagocytosis by a neighboring cell preceding any potential budding of the nucleus or cell itself. Granulosa cells near the antrum are sloughed off into the antrum, and their death has features more consistent with that of other cell types that undergo death as a result of terminal differentiation.

  10. The use of web ontology languages and other semantic web tools in drug discovery.

    Science.gov (United States)

    Chen, Huajun; Xie, Guotong

    2010-05-01

    To optimize drug development processes, pharmaceutical companies require principled approaches to integrate disparate data on a unified infrastructure, such as the web. The semantic web, developed on the web technology, provides a common, open framework capable of harmonizing diversified resources to enable networked and collaborative drug discovery. We survey the state of art of utilizing web ontologies and other semantic web technologies to interlink both data and people to support integrated drug discovery across domains and multiple disciplines. Particularly, the survey covers three major application categories including: i) semantic integration and open data linking; ii) semantic web service and scientific collaboration and iii) semantic data mining and integrative network analysis. The reader will gain: i) basic knowledge of the semantic web technologies; ii) an overview of the web ontology landscape for drug discovery and iii) a basic understanding of the values and benefits of utilizing the web ontologies in drug discovery. i) The semantic web enables a network effect for linking open data for integrated drug discovery; ii) The semantic web service technology can support instant ad hoc collaboration to improve pipeline productivity and iii) The semantic web encourages publishing data in a semantic way such as resource description framework attributes and thus helps move away from a reliance on pure textual content analysis toward more efficient semantic data mining.

  11. Web 3.0 Emerging

    Energy Technology Data Exchange (ETDEWEB)

    Hendler, James [Rensselaer Polytechnic Institute

    2012-02-22

    As more and more data and information becomes available on the Web, new technologies that use explicit semantics for information organization are becoming desirable. New terms such as Linked Data, Semantic Web and Web 3.0 are used more and more, although there is increasing confusion as to what each means. In this talk, I will describe how different sorts of models can be used to link data in different ways. I will particularly explore different kinds of Web applications, from Enterprise Data Integration to Web 3.0 startups, government data release, the different needs of Web 2.0 and 3.0, the growing interest in “semantic search”, and the underlying technologies that power these new approaches.

  12. Web Server Embedded System

    Directory of Open Access Journals (Sweden)

    Adharul Muttaqin

    2014-07-01

    Full Text Available Abstrak Embedded sistem saat ini menjadi perhatian khusus pada teknologi komputer, beberapa sistem operasi linux dan web server yang beraneka ragam juga sudah dipersiapkan untuk mendukung sistem embedded, salah satu aplikasi yang dapat digunakan dalam operasi pada sistem embedded adalah web server. Pemilihan web server pada lingkungan embedded saat ini masih jarang dilakukan, oleh karena itu penelitian ini dilakukan dengan menitik beratkan pada dua buah aplikasi web server yang tergolong memiliki fitur utama yang menawarkan “keringanan” pada konsumsi CPU maupun memori seperti Light HTTPD dan Tiny HTTPD. Dengan menggunakan parameter thread (users, ramp-up periods, dan loop count pada stress test embedded system, penelitian ini menawarkan solusi web server manakah diantara Light HTTPD dan Tiny HTTPD yang memiliki kecocokan fitur dalam penggunaan embedded sistem menggunakan beagleboard ditinjau dari konsumsi CPU dan memori. Hasil penelitian menunjukkan bahwa dalam hal konsumsi CPU pada beagleboard embedded system lebih disarankan penggunaan Light HTTPD dibandingkan dengan tiny HTTPD dikarenakan terdapat perbedaan CPU load yang sangat signifikan antar kedua layanan web tersebut Kata kunci: embedded system, web server Abstract Embedded systems are currently of particular concern in computer technology, some of the linux operating system and web server variegated also prepared to support the embedded system, one of the applications that can be used in embedded systems are operating on the web server. Selection of embedded web server on the environment is still rarely done, therefore this study was conducted with a focus on two web application servers belonging to the main features that offer a "lightness" to the CPU and memory consumption as Light HTTPD and Tiny HTTPD. By using the parameters of the thread (users, ramp-up periods, and loop count on a stress test embedded systems, this study offers a solution of web server which between the Light

  13. Applying Web Usage Mining for Personalizing Hyperlinks in Web-Based Adaptive Educational Systems

    Science.gov (United States)

    Romero, Cristobal; Ventura, Sebastian; Zafra, Amelia; de Bra, Paul

    2009-01-01

    Nowadays, the application of Web mining techniques in e-learning and Web-based adaptive educational systems is increasing exponentially. In this paper, we propose an advanced architecture for a personalization system to facilitate Web mining. A specific Web mining tool is developed and a recommender engine is integrated into the AHA! system in…

  14. Comparison of argon plasma coagulation in management of upper gastrointestinal angiodysplasia and gastric antral vascular ectasia hemorrhage.

    Science.gov (United States)

    Chiu, Yi-Chun; Lu, Lung-Sheng; Wu, Keng-Liang; Tam, William; Hu, Ming-Luen; Tai, Wei-Chen; Chiu, King-Wah; Chuah, Seng-Kee

    2012-06-09

    Vascular ectasias, including gastric antral vascular ectasia (GAVE) and angiodysplasia, are increasingly recognized as important sources of gastrointestinal bleeding. This study investigated and compared the efficacies and outcomes of treatment of upper gastrointestinal (UGI) angiodysplasia and GAVE hemorrhage by endoscopic argon plasma coagulation (APC). From January 2006 to December 2009, 46 patients diagnosed with upper GI bleeding caused by angiodysplasia or GAVE at a tertiary hospital were recruited into this study. They included 26 males and 20 females with an average age of 65.6 years (range, 45-90 years). All patients underwent APC for hemostasis during an endoscopic procedure. Parameters such as underlying co-morbidities, number of endoscopic treatment sessions, recurrent bleeding, and clinical outcomes during follow-up were analyzed. The 46 patients with UGI vascular ectasia hemorrhage included 27 patients with angiodysplasia and 19 with GAVE. The patients with angiodysplasia were older than those with GAVE (71.6 ± 10.2 years versus 61.8 ± 11.9 years, P = 0.005). More GAVE patients than angiodysplasia patients had co-existing liver cirrhosis (63.2% versus 25.9%, P = 0.012). The patients with GAVE had a higher rate of recurrent bleeding (78.9% versus 7.4%, P bleeding. Further multivariate analysis revealed that GAVE was the only independent risk factor for recurrent bleeding after APC treatment (OR = 0.027, P bleeding. The efficacy of APC treatment is greater for angiodysplasia than for vascular ectasia bleeding. GAVE patients have a higher recurrent bleeding rate and may require multiple treatment sessions for sustained hemostasis.

  15. An Automatic Web Service Composition Framework Using QoS-Based Web Service Ranking Algorithm.

    Science.gov (United States)

    Mallayya, Deivamani; Ramachandran, Baskaran; Viswanathan, Suganya

    2015-01-01

    Web service has become the technology of choice for service oriented computing to meet the interoperability demands in web applications. In the Internet era, the exponential addition of web services nominates the "quality of service" as essential parameter in discriminating the web services. In this paper, a user preference based web service ranking (UPWSR) algorithm is proposed to rank web services based on user preferences and QoS aspect of the web service. When the user's request cannot be fulfilled by a single atomic service, several existing services should be composed and delivered as a composition. The proposed framework allows the user to specify the local and global constraints for composite web services which improves flexibility. UPWSR algorithm identifies best fit services for each task in the user request and, by choosing the number of candidate services for each task, reduces the time to generate the composition plans. To tackle the problem of web service composition, QoS aware automatic web service composition (QAWSC) algorithm proposed in this paper is based on the QoS aspects of the web services and user preferences. The proposed framework allows user to provide feedback about the composite service which improves the reputation of the services.

  16. RS-WebPredictor

    DEFF Research Database (Denmark)

    Zaretzki, J.; Bergeron, C.; Huang, T.-W.

    2013-01-01

    Regioselectivity-WebPredictor (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOMs) on drug-like molecules. Predictions may be made for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19 and 2E1....... RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects.......Availability: RS-WebPredictor is accessible for free use at http://reccr.chem.rpi.edu/ Software/RS-WebPredictor....

  17. IL web tutorials

    DEFF Research Database (Denmark)

    Hyldegård, Jette; Lund, Haakon

    2012-01-01

    The paper presents the results from a study on information literacy in a higher education (HE) context based on a larger research project evaluating 3 Norwegian IL web tutorials at 6 universities and colleges in Norway. The aim was to evaluate how the 3 web tutorials served students’ information...... seeking and writing process in an study context and to identify barriers to the employment and use of the IL web tutorials, hence to the underlying information literacy intentions by the developer. Both qualitative and quantitative methods were employed. A clear mismatch was found between intention...... and use of the web tutorials. In addition, usability only played a minor role compared to relevance. It is concluded that the positive expectations of the IL web tutorials tend to be overrated by the developers. Suggestions for further research are presented....

  18. A development process meta-model for Web based expert systems: The Web engineering point of view

    DEFF Research Database (Denmark)

    Dokas, I.M.; Alapetite, Alexandre

    2006-01-01

    raised their complexity. Unfortunately, there is so far no clear answer to the question: How may the methods and experience of Web engineering and expert systems be combined and applied in order todevelop effective and successful Web based expert systems? In an attempt to answer this question...... on Web based expert systems – will be presented. The idea behind the presentation of theaccessibility evaluation and its conclusions is to show to Web based expert system developers, who typically have little Web engineering background, that Web engineering issues must be considered when developing Web......Similar to many legacy computer systems, expert systems can be accessed via the Web, forming a set of Web applications known as Web based expert systems. The tough Web competition, the way people and organizations rely on Web applications and theincreasing user requirements for better services have...

  19. Programming Web services with Perl

    CERN Document Server

    Ray, Randy J

    2003-01-01

    Given Perl's natural fit for web applications development, it's no surprise that Perl is also a natural choice for web services development. It's the most popular web programming language, with strong implementations of both SOAP and XML-RPC, the leading ways to distribute applications using web services. But books on web services focus on writing these applications in Java or Visual Basic, leaving Perl programmers with few resources to get them started. Programming Web Services with Perl changes that, bringing Perl users all the information they need to create web services using their favori

  20. Cooperative Mobile Web Browsing

    DEFF Research Database (Denmark)

    Perrucci, GP; Fitzek, FHP; Zhang, Qi

    2009-01-01

    This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data......-range links can then be used for cooperative mobile web browsing. By implementing the cooperative web browsing on commercial mobile phones, it will be shown that better performance is achieved in terms of increased data rate and therefore reduced access times, resulting in a significantly enhanced web...

  1. Web Portal Design, Execution and Sustainability for Naval Websites and Web Services

    National Research Council Canada - National Science Library

    Amsden, Saundra

    2003-01-01

    .... The newest Web Service is the development of Web Portals. Portals allow the design of Web Services in such a way as to allow users to define their own needs and create a home of their own within a site...

  2. Instant responsive web design

    CERN Document Server

    Simmons, Cory

    2013-01-01

    A step-by-step tutorial approach which will teach the readers what responsive web design is and how it is used in designing a responsive web page.If you are a web-designer looking to expand your skill set by learning the quickly growing industry standard of responsive web design, this book is ideal for you. Knowledge of CSS is assumed.

  3. SVG-Based Web Publishing

    Science.gov (United States)

    Gao, Jerry Z.; Zhu, Eugene; Shim, Simon

    2003-01-01

    With the increasing applications of the Web in e-commerce, advertising, and publication, new technologies are needed to improve Web graphics technology due to the current limitation of technology. The SVG (Scalable Vector Graphics) technology is a new revolutionary solution to overcome the existing problems in the current web technology. It provides precise and high-resolution web graphics using plain text format commands. It sets a new standard for web graphic format to allow us to present complicated graphics with rich test fonts and colors, high printing quality, and dynamic layout capabilities. This paper provides a tutorial overview about SVG technology and its essential features, capability, and advantages. The reports a comparison studies between SVG and other web graphics technologies.

  4. Sensor web

    Science.gov (United States)

    Delin, Kevin A. (Inventor); Jackson, Shannon P. (Inventor)

    2011-01-01

    A Sensor Web formed of a number of different sensor pods. Each of the sensor pods include a clock which is synchronized with a master clock so that all of the sensor pods in the Web have a synchronized clock. The synchronization is carried out by first using a coarse synchronization which takes less power, and subsequently carrying out a fine synchronization to make a fine sync of all the pods on the Web. After the synchronization, the pods ping their neighbors to determine which pods are listening and responded, and then only listen during time slots corresponding to those pods which respond.

  5. A Sensor Web and Web Service-Based Approach for Active Hydrological Disaster Monitoring

    Directory of Open Access Journals (Sweden)

    Xi Zhai

    2016-09-01

    Full Text Available Rapid advancements in Earth-observing sensor systems have led to the generation of large amounts of remote sensing data that can be used for the dynamic monitoring and analysis of hydrological disasters. The management and analysis of these data could take advantage of distributed information infrastructure technologies such as Web service and Sensor Web technologies, which have shown great potential in facilitating the use of observed big data in an interoperable, flexible and on-demand way. However, it remains a challenge to achieve timely response to hydrological disaster events and to automate the geoprocessing of hydrological disaster observations. This article proposes a Sensor Web and Web service-based approach to support active hydrological disaster monitoring. This approach integrates an event-driven mechanism, Web services, and a Sensor Web and coordinates them using workflow technologies to facilitate the Web-based sharing and processing of hydrological hazard information. The design and implementation of hydrological Web services for conducting various hydrological analysis tasks on the Web using dynamically updating sensor observation data are presented. An application example is provided to demonstrate the benefits of the proposed approach over the traditional approach. The results confirm the effectiveness and practicality of the proposed approach in cases of hydrological disaster.

  6. WebRTC using JSON via XMLHttpRequest and SIP over WebSocket: initial signalling overhead findings

    CSIR Research Space (South Africa)

    Adeyeye, M

    2013-08-01

    Full Text Available Web Real-Time Communication (WebRTC) introduces real-time multimedia communication as native capabilities of Web browsers. With the adoption of WebRTC the Web browsers will be able to use WebRTC to communicate with one another (peer...

  7. Webs and posets

    International Nuclear Information System (INIS)

    Dukes, M.; Gardi, E.; McAslan, H.; Scott, D.J.; White, C.D.

    2014-01-01

    The non-Abelian exponentiation theorem has recently been generalised to correlators of multiple Wilson line operators. The perturbative expansions of these correlators exponentiate in terms of sets of diagrams called webs, which together give rise to colour factors corresponding to connected graphs. The colour and kinematic degrees of freedom of individual diagrams in a web are entangled by mixing matrices of purely combinatorial origin. In this paper we relate the combinatorial study of these matrices to properties of partially ordered sets (posets), and hence obtain explicit solutions for certain families of web-mixing matrix, at arbitrary order in perturbation theory. We also provide a general expression for the rank of a general class of mixing matrices, which governs the number of independent colour factors arising from such webs. Finally, we use the poset language to examine a previously conjectured sum rule for the columns of web-mixing matrices which governs the cancellation of the leading subdivergences between diagrams in the web. Our results, when combined with parallel developments in the evaluation of kinematic integrals, offer new insights into the all-order structure of infrared singularities in non-Abelian gauge theories

  8. Advanced Techniques in Web Intelligence-2 Web User Browsing Behaviour and Preference Analysis

    CERN Document Server

    Palade, Vasile; Jain, Lakhmi

    2013-01-01

    This research volume focuses on analyzing the web user browsing behaviour and preferences in traditional web-based environments, social  networks and web 2.0 applications,  by using advanced  techniques in data acquisition, data processing, pattern extraction and  cognitive science for modeling the human actions.  The book is directed to  graduate students, researchers/scientists and engineers  interested in updating their knowledge with the recent trends in web user analysis, for developing the next generation of web-based systems and applications.

  9. Moving toward a universally accessible web: Web accessibility and education.

    Science.gov (United States)

    Kurt, Serhat

    2017-12-08

    The World Wide Web is an extremely powerful source of information, inspiration, ideas, and opportunities. As such, it has become an integral part of daily life for a great majority of people. Yet, for a significant number of others, the internet offers only limited value due to the existence of barriers which make accessing the Web difficult, if not impossible. This article illustrates some of the reasons that achieving equality of access to the online world of education is so critical, explores the current status of Web accessibility, discusses evaluative tools and methods that can help identify accessibility issues in educational websites, and provides practical recommendations and guidelines for resolving some of the obstacles that currently hinder the achievability of the goal of universal Web access.

  10. A demanding web-based PACS supported by web services technology

    Science.gov (United States)

    Costa, Carlos M. A.; Silva, Augusto; Oliveira, José L.; Ribeiro, Vasco G.; Ribeiro, José

    2006-03-01

    During the last years, the ubiquity of web interfaces have pushed practically all PACS suppliers to develop client applications in which clinical practitioners can receive and analyze medical images, using conventional personal computers and Web browsers. However, due to security and performance issues, the utilization of these software packages has been restricted to Intranets. Paradigmatically, one of the most important advantages of digital image systems is to simplify the widespread sharing and remote access of medical data between healthcare institutions. This paper analyses the traditional PACS drawbacks that contribute to their reduced usage in the Internet and describes a PACS based on Web Services technology that supports a customized DICOM encoding syntax and a specific compression scheme providing all historical patient data in a unique Web interface.

  11. BOWS (bioinformatics open web services) to centralize bioinformatics tools in web services.

    Science.gov (United States)

    Velloso, Henrique; Vialle, Ricardo A; Ortega, J Miguel

    2015-06-02

    Bioinformaticians face a range of difficulties to get locally-installed tools running and producing results; they would greatly benefit from a system that could centralize most of the tools, using an easy interface for input and output. Web services, due to their universal nature and widely known interface, constitute a very good option to achieve this goal. Bioinformatics open web services (BOWS) is a system based on generic web services produced to allow programmatic access to applications running on high-performance computing (HPC) clusters. BOWS intermediates the access to registered tools by providing front-end and back-end web services. Programmers can install applications in HPC clusters in any programming language and use the back-end service to check for new jobs and their parameters, and then to send the results to BOWS. Programs running in simple computers consume the BOWS front-end service to submit new processes and read results. BOWS compiles Java clients, which encapsulate the front-end web service requisitions, and automatically creates a web page that disposes the registered applications and clients. Bioinformatics open web services registered applications can be accessed from virtually any programming language through web services, or using standard java clients. The back-end can run in HPC clusters, allowing bioinformaticians to remotely run high-processing demand applications directly from their machines.

  12. Web Security, Privacy & Commerce

    CERN Document Server

    Garfinkel, Simson

    2011-01-01

    Since the first edition of this classic reference was published, World Wide Web use has exploded and e-commerce has become a daily part of business and personal life. As Web use has grown, so have the threats to our security and privacy--from credit card fraud to routine invasions of privacy by marketers to web site defacements to attacks that shut down popular web sites. Web Security, Privacy & Commerce goes behind the headlines, examines the major security risks facing us today, and explains how we can minimize them. It describes risks for Windows and Unix, Microsoft Internet Exp

  13. Funnel-web spider bite

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002844.htm Funnel-web spider bite To use the sharing features on ... the effects of a bite from the funnel-web spider. Male funnel-web spiders are more poisonous ...

  14. The polymorphic insertion of the luteinizing hormone receptor "insLQ" show a negative association to LHR gene expression and to the follicular fluid hormonal profile in human small antral follicles

    DEFF Research Database (Denmark)

    Borgbo, T; Chrudimska, J; Macek, M

    2018-01-01

    (AMHR2) and LHCGR, respectively, were observed for insLQ/insLQ compared to -/insLQ and the -/- genotypes. Moreover, LHCGR and CYP19a1 together with oestradiol and inhibin-B were significantly increased in -/insLQ compared to the -/- genotype. The homozygous insLQ genotype showed strong significant......The luteinizing hormone receptor (LHCGR) has a little studied polymorphic 6 bp insertion (rs4539842/insLQ). This study has evaluated the insLQ polymorphism in relation to potential associations with hormonal characteristics of human small antral follicles (hSAFs). In total, 310 hSAFs were collected...... from 86 women undergoing fertility preservation. Analysis included hormonal profile of 297 follicular fluid (FF) samples and 148 corresponding granulosa cells samples were evaluated by qPCR for selected genes. Significantly reduced and non-detectable mRNA levels of anti-Müllerian hormone receptor II...

  15. THE IMPORTANCE OF WEB DESIGN: VISUAL DESIGN EVALUATION OF DESTINATION WEB SITES

    OpenAIRE

    Fırlar, Belma; Okat Özdem, Özen

    2013-01-01

    As in the literature, the researchs about web site efficiency are mostly about site context. The analysis about function are mostly superficial. Whereas, controlling every little part of a web site respective is a necessity to show its efficiency. Here in this context in the study of perception and response event web sites that play an important role in visual design criteria are below the lens as featured and the web sites evaulated by heuristic evaluation method.The research focus of this s...

  16. Web Apollo: a web-based genomic annotation editing platform.

    Science.gov (United States)

    Lee, Eduardo; Helt, Gregg A; Reese, Justin T; Munoz-Torres, Monica C; Childers, Chris P; Buels, Robert M; Stein, Lincoln; Holmes, Ian H; Elsik, Christine G; Lewis, Suzanna E

    2013-08-30

    Web Apollo is the first instantaneous, collaborative genomic annotation editor available on the web. One of the natural consequences following from current advances in sequencing technology is that there are more and more researchers sequencing new genomes. These researchers require tools to describe the functional features of their newly sequenced genomes. With Web Apollo researchers can use any of the common browsers (for example, Chrome or Firefox) to jointly analyze and precisely describe the features of a genome in real time, whether they are in the same room or working from opposite sides of the world.

  17. Helicobacter pylori and precancerous conditions of the stomach: the frequency of infection in a cross-sectional study of 79 consecutive patients with chronic antral gastritis in Yaoundé, Cameroon.

    Science.gov (United States)

    Ankouane, Firmin; Noah, Dominique Noah; Enyime, Félicien Ntoné; Ndjollé, Carole Menzy; Djapa, Roger Nsenga; Nonga, Bernadette Ngo; Njoya, Oudou; Ndam, Elie Claude Ndjitoyap

    2015-01-01

    The study aimed at determining the different types of precancerous conditions of the stomach and searches the frequency of Helicobacter pylori in these lesions in patients with chronic antral gastritis in Yaounde, Cameroon. Five gastric biopsies were performed during upper gastrointestinal endoscopy for pathology and fixed in formol 10% before being coated in paraffin. Both the modified Giemsa and Periodic acid of Shift - Alkaline blue stains were used for the histological diagnosis of Helicobacter pylori infection. Hematoxylyn and eosin stain was used to determine the activity of gastritis, atrophic gastritis and intestinal metaplasia in accordance to the Sydney's classification of gastritis. Data were analysed using both the Epi info 6.04 and Excel 2007 softwares. Means and their standard deviations, medians and their interquartiles (IQR) were calculated. Proportions were established for qualitative variables and chi square analysis done in this study with a p value set at 0.05. Seventy-nine patients with chronic antral gastritis were enrolled, of which 43 (54.4%) were male, median age: 43 years (range from 21 to 70 years). The rate of atrophic gastritis was 74.7% (59/79). The activity of atrophic gastritis was mild in 47.5% (28/59) of cases, moderate in 47.5% (28/59) and severe in 5% (5/59). Intestinal metaplasia and follicular gastritis were present in 6.3% (5/79), and 10.1% (8/79), respectively. Concerning Helicobacter pylori infection, 71.2% (42/59) of patients with atrophic gastritis tested positive against 28.8% (17/59) who tested negative (p=0.00003). Helicobacter pylori infection was related to the severity of gastric atrophy (p=0.0001). Among patients with intestinal metaplasia and follicular gastritis, the proportion of those who tested positive for Helicobacter pylori infection was 80% (4/5), and 75% (6/8), respectively. There were no significant differences in the occurrence of atrophic gastritis according to age groups (p=0.908). This study concludes

  18. Teaching Web 2.0 technologies using Web 2.0 technologies.

    Science.gov (United States)

    Rethlefsen, Melissa L; Piorun, Mary; Prince, J Dale

    2009-10-01

    The research evaluated participant satisfaction with the content and format of the "Web 2.0 101: Introduction to Second Generation Web Tools" course and measured the impact of the course on participants' self-evaluated knowledge of Web 2.0 tools. The "Web 2.0 101" online course was based loosely on the Learning 2.0 model. Content was provided through a course blog and covered a wide range of Web 2.0 tools. All Medical Library Association members were invited to participate. Participants were asked to complete a post-course survey. Respondents who completed the entire course or who completed part of the course self-evaluated their knowledge of nine social software tools and concepts prior to and after the course using a Likert scale. Additional qualitative information about course strengths and weaknesses was also gathered. Respondents' self-ratings showed a significant change in perceived knowledge for each tool, using a matched pair Wilcoxon signed rank analysis (P<0.0001 for each tool/concept). Overall satisfaction with the course appeared high. Hands-on exercises were the most frequently identified strength of the course; the length and time-consuming nature of the course were considered weaknesses by some. Learning 2.0-style courses, though demanding time and self-motivation from participants, can increase knowledge of Web 2.0 tools.

  19. Uses and Gratifications of the World Wide Web: From Couch Potato to Web Potato.

    Science.gov (United States)

    Kaye, Barbara K.

    1998-01-01

    Investigates uses and gratifications of the World Wide Web and its impact on traditional mass media, especially television. Identifies six Web use motivations: entertainment, social interaction, passing of time, escape, information, and Web site preference. Examines relationships between each use motivation and Web affinity, perceived realism, and…

  20. The RCSB Protein Data Bank: redesigned web site and web services.

    Science.gov (United States)

    Rose, Peter W; Beran, Bojan; Bi, Chunxiao; Bluhm, Wolfgang F; Dimitropoulos, Dimitris; Goodsell, David S; Prlic, Andreas; Quesada, Martha; Quinn, Gregory B; Westbrook, John D; Young, Jasmine; Yukich, Benjamin; Zardecki, Christine; Berman, Helen M; Bourne, Philip E

    2011-01-01

    The RCSB Protein Data Bank (RCSB PDB) web site (http://www.pdb.org) has been redesigned to increase usability and to cater to a larger and more diverse user base. This article describes key enhancements and new features that fall into the following categories: (i) query and analysis tools for chemical structure searching, query refinement, tabulation and export of query results; (ii) web site customization and new structure alerts; (iii) pair-wise and representative protein structure alignments; (iv) visualization of large assemblies; (v) integration of structural data with the open access literature and binding affinity data; and (vi) web services and web widgets to facilitate integration of PDB data and tools with other resources. These improvements enable a range of new possibilities to analyze and understand structure data. The next generation of the RCSB PDB web site, as described here, provides a rich resource for research and education.

  1. WebQuests in special primary education: Learning in a web-based environment

    NARCIS (Netherlands)

    Kleemans, M.A.J.; Segers, P.C.J.; Droop, W.; Wentink, W.M.J.

    2011-01-01

    The present study investigated the differences in learning gain when performing a WebQuest with a well-defined versus an ill-defined assignment. Twenty boys and twenty girls (mean age 11; 10), attending a special primary education school, performed two WebQuests. In each WebQuest, they performed

  2. Web Science emerges

    OpenAIRE

    Shadbolt, Nigel; Berners-Lee, Tim

    2008-01-01

    The relentless rise in Web pages and links is creating emergent properties, from social networks to virtual identity theft, that are transforming society. A new discipline, Web Science, aims to discover how Web traits arise and how they can be harnessed or held in check to benefit society. Important advances are beginning to be made; more work can solve major issues such as securing privacy and conveying trust.

  3. Web Accessibility and Guidelines

    Science.gov (United States)

    Harper, Simon; Yesilada, Yeliz

    Access to, and movement around, complex online environments, of which the World Wide Web (Web) is the most popular example, has long been considered an important and major issue in the Web design and usability field. The commonly used slang phrase ‘surfing the Web’ implies rapid and free access, pointing to its importance among designers and users alike. It has also been long established that this potentially complex and difficult access is further complicated, and becomes neither rapid nor free, if the user is disabled. There are millions of people who have disabilities that affect their use of the Web. Web accessibility aims to help these people to perceive, understand, navigate, and interact with, as well as contribute to, the Web, and thereby the society in general. This accessibility is, in part, facilitated by the Web Content Accessibility Guidelines (WCAG) currently moving from version one to two. These guidelines are intended to encourage designers to make sure their sites conform to specifications, and in that conformance enable the assistive technologies of disabled users to better interact with the page content. In this way, it was hoped that accessibility could be supported. While this is in part true, guidelines do not solve all problems and the new WCAG version two guidelines are surrounded by controversy and intrigue. This chapter aims to establish the published literature related to Web accessibility and Web accessibility guidelines, and discuss limitations of the current guidelines and future directions.

  4. WebViz: A web browser based application for collaborative analysis of 3D data

    Science.gov (United States)

    Ruegg, C. S.

    2011-12-01

    In the age of high speed Internet where people can interact instantly, scientific tools have lacked technology which can incorporate this concept of communication using the web. To solve this issue a web application for geological studies has been created, tentatively titled WebViz. This web application utilizes tools provided by Google Web Toolkit to create an AJAX web application capable of features found in non web based software. Using these tools, a web application can be created to act as piece of software from anywhere in the globe with a reasonably speedy Internet connection. An application of this technology can be seen with data regarding the recent tsunami from the major japan earthquakes. After constructing the appropriate data to fit a computer render software called HVR, WebViz can request images of the tsunami data and display it to anyone who has access to the application. This convenience alone makes WebViz a viable solution, but the option to interact with this data with others around the world causes WebViz to be taken as a serious computational tool. WebViz also can be used on any javascript enabled browser such as those found on modern tablets and smart phones over a fast wireless connection. Due to the fact that WebViz's current state is built using Google Web Toolkit the portability of the application is in it's most efficient form. Though many developers have been involved with the project, each person has contributed to increase the usability and speed of the application. In the project's most recent form a dramatic speed increase has been designed as well as a more efficient user interface. The speed increase has been informally noticed in recent uses of the application in China and Australia with the hosting server being located at the University of Minnesota. The user interface has been improved to not only look better but the functionality has been improved. Major functions of the application are rotating the 3D object using buttons

  5. Web thickness determines the therapeutic effect of endoscopic keel placement on anterior glottic web.

    Science.gov (United States)

    Chen, Jian; Shi, Fang; Chen, Min; Yang, Yue; Cheng, Lei; Wu, Haitao

    2017-10-01

    This work is a retrospective analysis to investigate the critical risk factor for the therapeutic effect of endoscopic keel placement on anterior glottic web. Altogether, 36 patients with anterior glottic web undergoing endoscopic lysis and silicone keel placement were enrolled. Their voice qualities were evaluated using the voice handicap index-10 (VHI-10) questionnaire, and improved significantly 3 months after surgery (21.53 ± 3.89 vs 9.81 ± 6.68, P web recurrence during the at least 1-year follow-up. Therefore, patients were classified according to the Cohen classification or web thickness, and the recurrence rates were compared. The distribution of recurrence rates for Cohen type 1 ~ 4 were 28.6, 16.7, 33.3, and 40%, respectively. The difference was not statistically significant (P = 0.461). When classified by web thickness, only 2 of 27 (7.41%) thin type cases relapsed whereas 8 of 9 (88.9%) cases in the thick group reformed webs (P web thickness rather than the Cohen grades. Endoscopic lysis and keel placement is only effective for cases with thin glottic webs. Patients with thick webs should be treated by other means.

  6. Web cache location

    Directory of Open Access Journals (Sweden)

    Boffey Brian

    2004-01-01

    Full Text Available Stress placed on network infrastructure by the popularity of the World Wide Web may be partially relieved by keeping multiple copies of Web documents at geographically dispersed locations. In particular, use of proxy caches and replication provide a means of storing information 'nearer to end users'. This paper concentrates on the locational aspects of Web caching giving both an overview, from an operational research point of view, of existing research and putting forward avenues for possible further research. This area of research is in its infancy and the emphasis will be on themes and trends rather than on algorithm construction. Finally, Web caching problems are briefly related to referral systems more generally.

  7. Reactivity on the Web

    OpenAIRE

    Bailey, James; Bry, François; Eckert, Michael; Patrânjan, Paula Lavinia

    2005-01-01

    Reactivity, the ability to detect simple and composite events and respond in a timely manner, is an essential requirement in many present-day information systems. With the emergence of new, dynamic Web applications, reactivity on the Web is receiving increasing attention. Reactive Web-based systems need to detect and react not only to simple events but also to complex, real-life situations. This paper introduces XChange, a language for programming reactive behaviour on the Web,...

  8. Semantic Web status model

    CSIR Research Space (South Africa)

    Gerber, AJ

    2006-06-01

    Full Text Available Semantic Web application areas are experiencing intensified interest due to the rapid growth in the use of the Web, together with the innovation and renovation of information content technologies. The Semantic Web is regarded as an integrator across...

  9. Your Life in Web Apps

    CERN Document Server

    Turnbull, Giles

    2008-01-01

    What is a web app? It's software that you use right in your web browser. Rather than installing an application on your computer, you visit a web site and sign up as a new user of its software. Instead of storing your files on your own hard disk, the web app stores them for you, online. Is it possible to switch entirely to web apps? To run nothing but a browser for an entire day? In this PDF we'll take you through one day in the life of a web apps-only user and chronicle the pros and cons of living by browser. And if the idea of switching, fully or partially, to web apps sounds appealing to

  10. Web 25

    DEFF Research Database (Denmark)

    the reader on an exciting time travel journey to learn more about the prehistory of the hyperlink, the birth of the Web, the spread of the early Web, and the Web’s introduction to the general public in mainstream media. Fur- thermore, case studies of blogs, literature, and traditional media going online...

  11. Survey of Techniques for Deep Web Source Selection and Surfacing the Hidden Web Content

    OpenAIRE

    Khushboo Khurana; M.B. Chandak

    2016-01-01

    Large and continuously growing dynamic web content has created new opportunities for large-scale data analysis in the recent years. There is huge amount of information that the traditional web crawlers cannot access, since they use link analysis technique by which only the surface web can be accessed. Traditional search engine crawlers require the web pages to be linked to other pages via hyperlinks causing large amount of web data to be hidden from the crawlers. Enormous data is available in...

  12. Web 1.0 to Web 3.0 Evolution: Reviewing the Impacts on Tourism Development and Opportunities

    Science.gov (United States)

    Eftekhari, M. Hossein; Barzegar, Zeynab; Isaai, M. T.

    The most important event following the establishmenet of the Internet network was the Web introduced by Tim Berners-Lee. Websites give their owners features that allow sharing with which they can publish their content with users and visitors. In the last 5 years, we have seen some changes in the use of web. Users want to participate in content sharing and they like to interact with each other. This is known as Web 2.0. In the last year, Web 2.0 has reached maturity and now we need a smart web which will be accordingly be called Web 3.0. Web 3.0 is based on semantic web definition. Changing the way of using the web has had a clear impact on E-Tourism and its development and also on business models. In this paper, we review the definitions and describe the impacts of web evolution on E-Tourism.

  13. Working without a Crystal Ball: Predicting Web Trends for Web Services Librarians

    Science.gov (United States)

    Ovadia, Steven

    2008-01-01

    User-centered design is a principle stating that electronic resources, like library Web sites, should be built around the needs of the users. This article interviews Web developers of library and non-library-related Web sites, determining how they assess user needs and how they decide to adapt certain technologies for users. According to the…

  14. Private Web Browsing

    National Research Council Canada - National Science Library

    Syverson, Paul F; Reed, Michael G; Goldschlag, David M

    1997-01-01

    .... These are both kept confidential from network elements as well as external observers. Private Web browsing is achieved by unmodified Web browsers using anonymous connections by means of HTTP proxies...

  15. Microsoft Expression Web for dummies

    CERN Document Server

    Hefferman, Linda

    2013-01-01

    Expression Web is Microsoft's newest tool for creating and maintaining dynamic Web sites. This FrontPage replacement offers all the simple ""what-you-see-is-what-you-get"" tools for creating a Web site along with some pumped up new features for working with Cascading Style Sheets and other design options. Microsoft Expression Web For Dummies arrives in time for early adopters to get a feel for how to build an attractive Web site. Author Linda Hefferman teams up with longtime FrontPage For Dummies author Asha Dornfest to show the easy way for first-time Web designers, FrontPage ve

  16. SEMANTIC WEB MINING: ISSUES AND CHALLENGES

    OpenAIRE

    Karan Singh*, Anil kumar, Arun Kumar Yadav

    2016-01-01

    The combination of the two fast evolving scientific research areas “Semantic Web” and “Web Mining” are well-known as “Semantic Web Mining” in computer science. These two areas cover way for the mining of related and meaningful information from the web, by this means giving growth to the term “Semantic Web Mining”. The “Semantic Web” makes mining easy and “Web Mining” can construct new structure of Web. Web Mining applies Data Mining technique on web content, Structure and Usage. This paper gi...

  17. WebQuests in Special Primary Education: Learning in a Web-Based Environment

    Science.gov (United States)

    Kleemans, Tijs; Segers, Eliane; Droop, Mienke; Wentink, Hanneke

    2011-01-01

    The present study investigated the differences in learning gain when performing a WebQuest with a well-defined versus an ill-defined assignment. Twenty boys and twenty girls (mean age 11; 10), attending a special primary education school, performed two WebQuests. In each WebQuest, they performed either a well-defined or an ill-defined assignment.…

  18. TMFoldWeb: a web server for predicting transmembrane protein fold class.

    Science.gov (United States)

    Kozma, Dániel; Tusnády, Gábor E

    2015-09-17

    Here we present TMFoldWeb, the web server implementation of TMFoldRec, a transmembrane protein fold recognition algorithm. TMFoldRec uses statistical potentials and utilizes topology filtering and a gapless threading algorithm. It ranks template structures and selects the most likely candidates and estimates the reliability of the obtained lowest energy model. The statistical potential was developed in a maximum likelihood framework on a representative set of the PDBTM database. According to the benchmark test the performance of TMFoldRec is about 77 % in correctly predicting fold class for a given transmembrane protein sequence. An intuitive web interface has been developed for the recently published TMFoldRec algorithm. The query sequence goes through a pipeline of topology prediction and a systematic sequence to structure alignment (threading). Resulting templates are ordered by energy and reliability values and are colored according to their significance level. Besides the graphical interface, a programmatic access is available as well, via a direct interface for developers or for submitting genome-wide data sets. The TMFoldWeb web server is unique and currently the only web server that is able to predict the fold class of transmembrane proteins while assigning reliability scores for the prediction. This method is prepared for genome-wide analysis with its easy-to-use interface, informative result page and programmatic access. Considering the info-communication evolution in the last few years, the developed web server, as well as the molecule viewer, is responsive and fully compatible with the prevalent tablets and mobile devices.

  19. Measurment of Web Usability: Web Page of Hacettepe University Department of Information Management

    OpenAIRE

    Nazan Özenç Uçak; Tolga Çakmak

    2009-01-01

    Today, information is produced increasingly in electronic form and retrieval of information is provided via web pages. As a result of the rise of the number of web pages, many of them seem to comprise similar contents but different designs. In this respect, presenting information over the web pages according to user expectations and specifications is important in terms of effective usage of information. This study provides an insight about web usability studies that are executed for measuring...

  20. Effect of bovine pellucid zone 3 monoclonal antibodies on B cell lymphoma 2 expressions of granulosa cell and mice (Mus musculus follicle diameter

    Directory of Open Access Journals (Sweden)

    Heti Ira Ayue

    2017-01-01

    Full Text Available Objective: To evaluate the effects of pellucid zone 3 monoclonal antibodies against B-cell lymphoma 2 (BCL-2 expression and mice follicle diameter at various time periods.Methods: The animal model of this study was 36 Balb/c mice (Mus musculus. A true experimental design was used with a post-test only control group approach. BCL-2 expression was observed using immunohistochemistry, while the follicle diameter was observed by haematoxylin-eosin staining. The data was analyzed using nested ANOVA to compare the results of the mean expression of BCL-2 on the 5th and 20th day of observation in the pre-antral and antral follicle between the control and treatment groups.Results: No significant differences were found in BCL-2 gene expression. There were also no significant differences in BCL-2 expression on the 10th day of pre-antral follicle analysis. Moreover, there were no significant differences between the mean follicle diameter on the 5th, 10th, and 20th day of pre-antral and antral follicle development between the control and treatment groups. The addition of bovine pellucid zone 3 (bZP3 monoclonal antibodies on the 5th and 20th day of observation did not decrease the expression of BCL-2 gene in the pre-antral and antral follicle of mice. Administering bZP3 monoclonal antibodies on the 10th day of observation did not affect BCL-2 expression in the pre-antral follicle but did decrease BCL-2 expression in the antral follicle. Supplying bZP3 monoclonal antibodies on the 5th, 10th and 20th day did not affect the diameter of pre-antral and antral follicles of the mice.Conclusion: The monoclonal antibodies bovine zona pelusida 3 has the potential to be developed as a safe immunocontraception preparation.

  1. EPA Web Taxonomy

    Data.gov (United States)

    U.S. Environmental Protection Agency — EPA's Web Taxonomy is a faceted hierarchical vocabulary used to tag web pages with terms from a controlled vocabulary. Tagging enables search and discovery of EPA's...

  2. WebTag: Web browsing into sensor tags over NFC.

    Science.gov (United States)

    Echevarria, Juan Jose; Ruiz-de-Garibay, Jonathan; Legarda, Jon; Alvarez, Maite; Ayerbe, Ana; Vazquez, Juan Ignacio

    2012-01-01

    Information and Communication Technologies (ICTs) continue to overcome many of the challenges related to wireless sensor monitoring, such as for example the design of smarter embedded processors, the improvement of the network architectures, the development of efficient communication protocols or the maximization of the life cycle autonomy. This work tries to improve the communication link of the data transmission in wireless sensor monitoring. The upstream communication link is usually based on standard IP technologies, but the downstream side is always masked with the proprietary protocols used for the wireless link (like ZigBee, Bluetooth, RFID, etc.). This work presents a novel solution (WebTag) for a direct IP based access to a sensor tag over the Near Field Communication (NFC) technology for secure applications. WebTag allows a direct web access to the sensor tag by means of a standard web browser, it reads the sensor data, configures the sampling rate and implements IP based security policies. It is, definitely, a new step towards the evolution of the Internet of Things paradigm.

  3. From Web accessibility to Web adaptability.

    Science.gov (United States)

    Kelly, Brian; Nevile, Liddy; Sloan, David; Fanou, Sotiris; Ellison, Ruth; Herrod, Lisa

    2009-07-01

    This article asserts that current approaches to enhance the accessibility of Web resources fail to provide a solid foundation for the development of a robust and future-proofed framework. In particular, they fail to take advantage of new technologies and technological practices. The article introduces a framework for Web adaptability, which encourages the development of Web-based services that can be resilient to the diversity of uses of such services, the target audience, available resources, technical innovations, organisational policies and relevant definitions of 'accessibility'. The article refers to a series of author-focussed approaches to accessibility through which the authors and others have struggled to find ways to promote accessibility for people with disabilities. These approaches depend upon the resource author's determination of the anticipated users' needs and their provision. Through approaches labelled as 1.0, 2.0 and 3.0, the authors have widened their focus to account for contexts and individual differences in target audiences. Now, the authors want to recognise the role of users in determining their engagement with resources (including services). To distinguish this new approach, the term 'adaptability' has been used to replace 'accessibility'; new definitions of accessibility have been adopted, and the authors have reviewed their previous work to clarify how it is relevant to the new approach. Accessibility 1.0 is here characterised as a technical approach in which authors are told how to construct resources for a broadly defined audience. This is known as universal design. Accessibility 2.0 was introduced to point to the need to account for the context in which resources would be used, to help overcome inadequacies identified in the purely technical approach. Accessibility 3.0 moved the focus on users from a homogenised universal definition to recognition of the idiosyncratic needs and preferences of individuals and to cater for them. All of

  4. Web-based interventions in nursing.

    Science.gov (United States)

    Im, Eun-Ok; Chang, Sun Ju

    2013-02-01

    With recent advances in computer and Internet technologies and high funding priority on technological aspects of nursing research, researchers at the field level began to develop, use, and test various types of Web-based interventions. Despite high potential impacts of Web-based interventions, little is still known about Web-based interventions in nursing. In this article, to identify strengths and weaknesses of Web-based nursing interventions, a literature review was conducted using multiple databases with combined keywords of "online," "Internet" or "Web," "intervention," and "nursing." A total of 95 articles were retrieved through the databases and sorted by research topics. These articles were then analyzed to identify strengths and weaknesses of Web-based interventions in nursing. A strength of the Web-based interventions was their coverage of various content areas. In addition, many of them were theory-driven. They had advantages in their flexibility and comfort. They could provide consistency in interventions and require less cost in the intervention implementation. However, Web-based intervention studies had selected participants. They lacked controllability and had high dropouts. They required technical expertise and high development costs. Based on these findings, directions for future Web-based intervention research were provided.

  5. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial.

    Science.gov (United States)

    Hung, Emily W; Mayes, Maureen D; Sharif, Roozbeh; Assassi, Shervin; Machicao, Victor I; Hosing, Chitra; St Clair, E William; Furst, Daniel E; Khanna, Dinesh; Forman, Stephen; Mineishi, Shin; Phillips, Kristine; Seibold, James R; Bredeson, Christopher; Csuka, Mary Ellen; Nash, Richard A; Wener, Mark H; Simms, Robert; Ballen, Karen; Leclercq, Sharon; Storek, Jan; Goldmuntz, Ellen; Welch, Beverly; Keyes-Elstein, Lynette; Castina, Sharon; Crofford, Leslie J; Mcsweeney, Peter; Sullivan, Keith M

    2013-04-01

    To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic sclerosis (SSc). Subjects with early, diffuse SSc and evidence of specific internal organ involvement were considered for the Scleroderma: Cyclophosphamide Or Transplant (SCOT) trial. In the screening procedures, all patients underwent upper gastrointestinal endoscopy. Patients were then categorized into those with or without endoscopic evidence of GAVE. Demographic data, clinical disease characteristics, and autoantibody data were compared using Pearson chi-square or Student t tests. Twenty-three of 103 (22.3%) individuals were found to have GAVE on endoscopy. Although not statistically significant, anti-topoisomerase I (anti-Scl70) was detected less frequently among those with GAVE (18.8% vs 44.7%; p = 0.071). Similarly, anti-RNP antibodies (anti-U1 RNP) showed a trend to a negative association with GAVE (0 vs 18.4%; p = 0.066). There was no association between anti-RNA polymerase III and GAVE. Patients with GAVE had significantly more erythema or vascular ectasias in other parts of the stomach (26.1% vs 5.0%; p = 0.003). Endoscopic GAVE was present on screening in almost one-fourth of these highly selected patients with early and severe diffuse SSc. While anti-Scl70 and anti-U1 RNP trended toward a negative association with GAVE, there was no correlation between anti-RNA Pol III and GAVE. Patients with GAVE had a higher frequency of other gastric vascular ectasias outside the antrum, suggesting that GAVE may represent part of the spectrum of the vasculopathy in SSc.

  6. UrbanWeb: a Platform for Mobile, Context-aware Web Services

    DEFF Research Database (Denmark)

    Hansen, Frank Allan; Grønbæk, Kaj

    2011-01-01

    much benefit from being informed about the user’s context and tailored to the user’s location or the activities the user is engaged in. In this article we focus on the definition of context and context-awareness for mobile Web 2.0 services and we present a framework, UrbanWeb, which has been designed......’s context from sensors in today mobile phones, ranging from GPS data, to 2D visual barcodes, and manual entry of context information and how to utilize this information in Web applications. Finally a number of applications built with the framework are presented.......Faster Internet connections on the mobile Internet and new advanced mobile terminals make it possible to use Web 2.0 applications and service beyond the desktop wherever and whenever you want. However, even though some service may scale in their current form to the mobile Internet, others will very...

  7. Web party effect: a cocktail party effect in the web environment

    OpenAIRE

    Sara Rigutti; Carlo Fantoni; Walter Gerbino

    2015-01-01

    In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of ...

  8. Designing usable web forms- Empirical evaluation of web form improvement guidelines

    DEFF Research Database (Denmark)

    Seckler, Mirjam; Heinz, Silvia; Bargas-Avila, Javier A.

    2014-01-01

    This study reports a controlled eye tracking experiment (N = 65) that shows the combined effectiveness of 20 guidelines to improve interactive online forms when applied to forms found on real company websites. Results indicate that improved web forms lead to faster completion times, fewer form...... submission trials, and fewer eye movements. Data from subjective questionnaires and interviews further show increased user satisfaction. Overall, our findings highlight the importance for web designers to improve their web forms using UX guidelines....

  9. River food webs: an integrative approach to bottom-up flow webs, top-down impact webs, and trophic position.

    Science.gov (United States)

    Benke, Arthur C

    2018-03-31

    The majority of food web studies are based on connectivity, top-down impacts, bottom-up flows, or trophic position (TP), and ecologists have argued for decades which is best. Rarely have any two been considered simultaneously. The present study uses a procedure that integrates the last three approaches based on taxon-specific secondary production and gut analyses. Ingestion flows are quantified to create a flow web and the same data are used to quantify TP for all taxa. An individual predator's impacts also are estimated using the ratio of its ingestion (I) of each prey to prey production (P) to create an I/P web. This procedure was applied to 41 invertebrate taxa inhabiting submerged woody habitat in a southeastern U.S. river. A complex flow web starting with five basal food resources had 462 flows >1 mg·m -2 ·yr -1 , providing far more information than a connectivity web. Total flows from basal resources to primary consumers/omnivores were dominated by allochthonous amorphous detritus and ranged from 1 to >50,000 mg·m -2 ·yr -1 . Most predator-prey flows were much lower (1,000  mg·m -2 ·yr -1 . The I/P web showed that 83% of individual predator impacts were weak (90%). Quantitative estimates of TP ranged from 2 to 3.7, contrasting sharply with seven integer-based trophic levels based on longest feeding chain. Traditional omnivores (TP = 2.4-2.9) played an important role by consuming more prey and exerting higher impacts on primary consumers than strict predators (TP ≥ 3). This study illustrates how simultaneous quantification of flow pathways, predator impacts, and TP together provide an integrated characterization of natural food webs. © 2018 by the Ecological Society of America.

  10. Practical web development

    CERN Document Server

    Wellens, Paul

    2015-01-01

    This book is perfect for beginners who want to get started and learn the web development basics, but also offers experienced developers a web development roadmap that will help them to extend their capabilities.

  11. An Efficient Approach for Web Indexing of Big Data through Hyperlinks in Web Crawling

    Science.gov (United States)

    Devi, R. Suganya; Manjula, D.; Siddharth, R. K.

    2015-01-01

    Web Crawling has acquired tremendous significance in recent times and it is aptly associated with the substantial development of the World Wide Web. Web Search Engines face new challenges due to the availability of vast amounts of web documents, thus making the retrieved results less applicable to the analysers. However, recently, Web Crawling solely focuses on obtaining the links of the corresponding documents. Today, there exist various algorithms and software which are used to crawl links from the web which has to be further processed for future use, thereby increasing the overload of the analyser. This paper concentrates on crawling the links and retrieving all information associated with them to facilitate easy processing for other uses. In this paper, firstly the links are crawled from the specified uniform resource locator (URL) using a modified version of Depth First Search Algorithm which allows for complete hierarchical scanning of corresponding web links. The links are then accessed via the source code and its metadata such as title, keywords, and description are extracted. This content is very essential for any type of analyser work to be carried on the Big Data obtained as a result of Web Crawling. PMID:26137592

  12. Architecture and the Web.

    Science.gov (United States)

    Money, William H.

    Instructors should be concerned with how to incorporate the World Wide Web into an information systems (IS) curriculum organized across three areas of knowledge: information technology, organizational and management concepts, and theory and development of systems. The Web fits broadly into the information technology component. For the Web to be…

  13. SaaS ve web designu

    OpenAIRE

    Míka, Filip

    2011-01-01

    This thesis is aimed to evaluate if the current SaaS market is able to meet functional re-quirements of web design in order to appropriately support web design's activities. The theoretical part introduces the web design model which describes web design's functional requirements. The next section presents a research concept that describes model assessment (i.e. solutions delivered as SaaS that support web design) and evaluation process. The results show that the current SaaS market is able to...

  14. Programming the semantic web

    CERN Document Server

    Segaran, Toby; Taylor, Jamie

    2009-01-01

    With this book, the promise of the Semantic Web -- in which machines can find, share, and combine data on the Web -- is not just a technical possibility, but a practical reality Programming the Semantic Web demonstrates several ways to implement semantic web applications, using current and emerging standards and technologies. You'll learn how to incorporate existing data sources into semantically aware applications and publish rich semantic data. Each chapter walks you through a single piece of semantic technology and explains how you can use it to solve real problems. Whether you're writing

  15. RESTful Web Services Cookbook

    CERN Document Server

    Allamaraju, Subbu

    2010-01-01

    While the REST design philosophy has captured the imagination of web and enterprise developers alike, using this approach to develop real web services is no picnic. This cookbook includes more than 100 recipes to help you take advantage of REST, HTTP, and the infrastructure of the Web. You'll learn ways to design RESTful web services for client and server applications that meet performance, scalability, reliability, and security goals, no matter what programming language and development framework you use. Each recipe includes one or two problem statements, with easy-to-follow, step-by-step i

  16. SPARQLGraph: a web-based platform for graphically querying biological Semantic Web databases.

    Science.gov (United States)

    Schweiger, Dominik; Trajanoski, Zlatko; Pabinger, Stephan

    2014-08-15

    Semantic Web has established itself as a framework for using and sharing data across applications and database boundaries. Here, we present a web-based platform for querying biological Semantic Web databases in a graphical way. SPARQLGraph offers an intuitive drag & drop query builder, which converts the visual graph into a query and executes it on a public endpoint. The tool integrates several publicly available Semantic Web databases, including the databases of the just recently released EBI RDF platform. Furthermore, it provides several predefined template queries for answering biological questions. Users can easily create and save new query graphs, which can also be shared with other researchers. This new graphical way of creating queries for biological Semantic Web databases considerably facilitates usability as it removes the requirement of knowing specific query languages and database structures. The system is freely available at http://sparqlgraph.i-med.ac.at.

  17. Chemistry WebBook

    Science.gov (United States)

    SRD 69 NIST Chemistry WebBook (Web, free access)   The NIST Chemistry WebBook contains: Thermochemical data for over 7000 organic and small inorganic compounds; thermochemistry data for over 8000 reactions; IR spectra for over 16,000 compounds; mass spectra for over 33,000 compounds; UV/Vis spectra for over 1600 compounds; electronic and vibrational spectra for over 5000 compounds; constants of diatomic molecules(spectroscopic data) for over 600 compounds; ion energetics data for over 16,000 compounds; thermophysical property data for 74 fluids.

  18. PERBANDINGAN ANTARA “BIG” WEB SERVICE DENGAN RESTFUL WEB SERVICE UNTUK INTEGRASI DATA BERFORMAT GML

    Directory of Open Access Journals (Sweden)

    Adi Nugroho

    2012-01-01

    Full Text Available Web Service with Java: SOAP (JAX-WS/Java API for XML Web Services and Java RESTful Web Service (JAX-RS/Java RESTful API for XML Web Services are now a technology competing with each other in terms of their use for integrates data residing in different systems. Both Web Service technologies, of course, have advantages and disadvantages. In this paper, we discuss the comparison of the two technologies is a Java Web Service in relation to the development of GIS application (Geographic Information System integrates the use of data-formatted GML (Geography Markup Language, which is stored in the system database XML (eXtensible Markup Language.

  19. MR imaging of carotid webs

    International Nuclear Information System (INIS)

    Boesen, Mari E.; Eswaradass, Prasanna Venkatesan; Singh, Dilip; Mitha, Alim P.; Menon, Bijoy K.; Goyal, Mayank; Frayne, Richard

    2017-01-01

    We propose a magnetic resonance (MR) imaging protocol for the characterization of carotid web morphology, composition, and vessel wall dynamics. The purpose of this case series was to determine the feasibility of imaging carotid webs with MR imaging. Five patients diagnosed with carotid web on CT angiography were recruited to undergo a 30-min MR imaging session. MR angiography (MRA) images of the carotid artery bifurcation were acquired. Multi-contrast fast spin echo (FSE) images were acquired axially about the level of the carotid web. Two types of cardiac phase resolved sequences (cineFSE and cine phase contrast) were acquired to visualize the elasticity of the vessel wall affected by the web. Carotid webs were identified on MRA in 5/5 (100%) patients. Multi-contrast FSE revealed vessel wall thickening and cineFSE demonstrated regional changes in distensibility surrounding the webs in these patients. Our MR imaging protocol enables an in-depth evaluation of patients with carotid webs: morphology (by MRA), composition (by multi-contrast FSE), and wall dynamics (by cineFSE). (orig.)

  20. MR imaging of carotid webs

    Energy Technology Data Exchange (ETDEWEB)

    Boesen, Mari E. [University of Calgary, Department of Biomedical Engineering, Calgary (Canada); Foothills Medical Centre, Seaman Family MR Research Centre, Calgary (Canada); Eswaradass, Prasanna Venkatesan; Singh, Dilip; Mitha, Alim P.; Menon, Bijoy K. [University of Calgary, Department of Clinical Neurosciences, Calgary (Canada); Foothills Medical Centre, Calgary Stroke Program, Calgary (Canada); Goyal, Mayank [Foothills Medical Centre, Calgary Stroke Program, Calgary (Canada); University of Calgary, Department of Radiology, Calgary (Canada); Frayne, Richard [Foothills Medical Centre, Seaman Family MR Research Centre, Calgary (Canada); University of Calgary, Hotchkiss Brain Institute, Calgary (Canada)

    2017-04-15

    We propose a magnetic resonance (MR) imaging protocol for the characterization of carotid web morphology, composition, and vessel wall dynamics. The purpose of this case series was to determine the feasibility of imaging carotid webs with MR imaging. Five patients diagnosed with carotid web on CT angiography were recruited to undergo a 30-min MR imaging session. MR angiography (MRA) images of the carotid artery bifurcation were acquired. Multi-contrast fast spin echo (FSE) images were acquired axially about the level of the carotid web. Two types of cardiac phase resolved sequences (cineFSE and cine phase contrast) were acquired to visualize the elasticity of the vessel wall affected by the web. Carotid webs were identified on MRA in 5/5 (100%) patients. Multi-contrast FSE revealed vessel wall thickening and cineFSE demonstrated regional changes in distensibility surrounding the webs in these patients. Our MR imaging protocol enables an in-depth evaluation of patients with carotid webs: morphology (by MRA), composition (by multi-contrast FSE), and wall dynamics (by cineFSE). (orig.)

  1. A survey on web modeling approaches for ubiquitous web applications

    NARCIS (Netherlands)

    Schwinger, W.; Retschitzegger, W.; Schauerhuber, A.; Kappel, G.; Wimmer, M.; Pröll, B.; Cachero Castro, C.; Casteleyn, S.; De Troyer, O.; Fraternali, P.; Garrigos, I.; Garzotto, F.; Ginige, A.; Houben, G.J.P.M.; Koch, N.; Moreno, N.; Pastor, O.; Paolini, P.; Pelechano Ferragud, V.; Rossi, G.; Schwabe, D.; Tisi, M.; Vallecillo, A.; Sluijs, van der K.A.M.; Zhang, G.

    2008-01-01

    Purpose – Ubiquitous web applications (UWA) are a new type of web applications which are accessed in various contexts, i.e. through different devices, by users with various interests, at anytime from anyplace around the globe. For such full-fledged, complex software systems, a methodologically sound

  2. Classification of the web

    DEFF Research Database (Denmark)

    Mai, Jens Erik

    2004-01-01

    This paper discusses the challenges faced by investigations into the classification of the Web and outlines inquiries that are needed to use principles for bibliographic classification to construct classifications of the Web. This paper suggests that the classification of the Web meets challenges...... that call for inquiries into the theoretical foundation of bibliographic classification theory....

  3. Maintenance-Ready Web Application Development

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2016-01-01

    Full Text Available The current paper tackles the subject of developing maintenance-ready web applications. Maintenance is presented as a core stage in a web application’s lifecycle. The concept of maintenance-ready is defined in the context of web application development. Web application maintenance tasks types are enunciated and suitable task types are identified for further analysis. The research hypothesis is formulated based on a direct link between tackling maintenance in the development stage and reducing overall maintenance costs. A live maintenance-ready web application is presented and maintenance related aspects are highlighted. The web application’s features, that render it maintenance-ready, are emphasize. The cost of designing and building the web-application to be maintenance-ready are disclosed. The savings in maintenance development effort facilitated by maintenance ready features are also disclosed. Maintenance data is collected from 40 projects implemented by a web development company. Homogeneity and diversity of collected data is evaluated. A data sample is presented and the size and comprehensive nature of the entire dataset is depicted. Research hypothesis are validated and conclusions are formulated on the topic of developing maintenance-ready web applications. The limits of the research process which represented the basis for the current paper are enunciated. Future research topics are submitted for debate.

  4. Personalized Metaheuristic Clustering Onto Web Documents

    Institute of Scientific and Technical Information of China (English)

    Wookey Lee

    2004-01-01

    Optimal clustering for the web documents is known to complicated cornbinatorial Optimization problem and it is hard to develop a generally applicable oplimal algorithm. An accelerated simuIated arlneaIing aIgorithm is developed for automatic web document classification. The web document classification problem is addressed as the problem of best describing a match between a web query and a hypothesized web object. The normalized term frequency and inverse document frequency coefficient is used as a measure of the match. Test beds are generated on - line during the search by transforming model web sites. As a result, web sites can be clustered optimally in terms of keyword vectofs of corresponding web documents.

  5. Designing a WebQuest

    Science.gov (United States)

    Salsovic, Annette R.

    2009-01-01

    A WebQuest is an inquiry-based lesson plan that uses the Internet. This article explains what a WebQuest is, shows how to create one, and provides an example. When engaged in a WebQuest, students use technology to experience cooperative learning and discovery learning while honing their research, writing, and presentation skills. It has been found…

  6. Web-Based Inquiry Learning: Facilitating Thoughtful Literacy with WebQuests

    Science.gov (United States)

    Ikpeze, Chinwe H.; Boyd, Fenice B.

    2007-01-01

    An action research study investigated how the multiple tasks found in WebQuests facilitate fifth-grade students' literacy skills and higher order thinking. Findings indicate that WebQuests are most successful when activities are carefully selected and systematically delivered. Implications for teaching include the necessity for adequate planning,…

  7. Work of the Web Weavers: Web Development in Academic Libraries

    Science.gov (United States)

    Bundza, Maira; Vander Meer, Patricia Fravel; Perez-Stable, Maria A.

    2009-01-01

    Although the library's Web site has become a standard tool for seeking information and conducting research in academic institutions, there are a variety of ways libraries approach the often challenging--and sometimes daunting--process of Web site development and maintenance. Three librarians at Western Michigan University explored issues related…

  8. Web 2.0 i undervisningen

    DEFF Research Database (Denmark)

    Liburd, Janne J.; Christensen, Inger-Marie F.

    2011-01-01

    Temahæfte om web 2.0, der formidler viden om og inspiration til at arbejde med web 2.0 teknologier i videregående uddannelser. Hæftet introducerer sociale medier og web 2.0, og der redegøres for teoretisk funderede læreprocesser med web 2.0, og hvorledes disse kan indtænkes i undervisningsforløb....... Hæftet præsenterer endvidere en metode til design af læringsaktiviteter med web 2.0, og giver en række eksempler på konkrete forløb....

  9. Historical Quantitative Reasoning on the Web

    NARCIS (Netherlands)

    Meroño-Peñuela, A.; Ashkpour, A.

    2016-01-01

    The Semantic Web is an extension of the Web through standards by the World Wide Web Consortium (W3C) [4]. These standards promote common data formats and exchange protocols on the Web, most fundamentally the Resource Description Framework (RDF). Its ultimate goal is to make the Web a suitable data

  10. Building Social Web Applications

    CERN Document Server

    Bell, Gavin

    2009-01-01

    Building a web application that attracts and retains regular visitors is tricky enough, but creating a social application that encourages visitors to interact with one another requires careful planning. This book provides practical solutions to the tough questions you'll face when building an effective community site -- one that makes visitors feel like they've found a new home on the Web. If your company is ready to take part in the social web, this book will help you get started. Whether you're creating a new site from scratch or reworking an existing site, Building Social Web Applications

  11. The Creative Web.

    Science.gov (United States)

    Yudess, Jo

    2003-01-01

    This article lists the Web sites of 12 international not-for-profit creativity associations designed to trigger more creative thought and research possibilities. Along with Web addresses, the entries include telephone contact information and a brief description of the organization. (CR)

  12. Engineering Adaptive Web Applications

    DEFF Research Database (Denmark)

    Dolog, Peter

    2007-01-01

    suit the user profile the most. This paper summarizes the domain engineering framework for such adaptive web applications. The framework provides guidelines to develop adaptive web applications as members of a family. It suggests how to utilize the design artifacts as knowledge which can be used......Information and services on the web are accessible for everyone. Users of the web differ in their background, culture, political and social environment, interests and so on. Ambient intelligence was envisioned as a concept for systems which are able to adapt to user actions and needs....... With the growing amount of information and services, the web applications become natural candidates to adopt the concepts of ambient intelligence. Such applications can deal with divers user intentions and actions based on the user profile and can suggest the combination of information content and services which...

  13. Physician training protocol within the WEB Intrasaccular Therapy (WEB-IT) study.

    Science.gov (United States)

    Arthur, Adam; Hoit, Daniel; Coon, Alexander; Delgado Almandoz, Josser E; Elijovich, Lucas; Cekirge, Saruhan; Fiorella, David

    2018-05-01

    The WEB Intra-saccular Therapy (WEB-IT) trial is an investigational device exemption study to demonstrate the safety and effectiveness of the WEB device for the treatment of wide-neck bifurcation aneurysms. The neurovascular replicator (Vascular Simulations, Stony Brook, New York, USA) creates a physical environment that replicates patient-specific neurovascular anatomy and hemodynamic physiology, and allows devices to be implanted under fluoroscopic guidance. To report the results of a unique neurovascular replicator-based training program, which was incorporated into the WEB-IT study to optimize technical performance and patient safety. US investigators participated in a new training program that incorporated full surgical rehearsals on a neurovascular replicator. No roll-in cases were permitted within the trial. Custom replicas of patient-specific neurovascular anatomy were created for the initial cases treated at each center, as well as for cases expected to be challenging. On-site surgical rehearsals were performed before these procedures. A total of 48 participating investigators at 25 US centers trained using the replicator. Sessions included centralized introductory training, on-site training, and patient-specific full surgical rehearsal. Fluoroscopy and procedure times in the WEB-IT study were not significantly different from those seen in two European trials where participating physicians had significant WEB procedure experience before study initiation. A new program of neurovascular-replicator-based physician training was employed within the WEB-IT study. This represents a new methodology for education and training that may be an effective means to optimize technical success and patient safety during the introduction of a new technology. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Stochastic analysis of web page ranking

    NARCIS (Netherlands)

    Volkovich, Y.

    2009-01-01

    Today, the study of the World Wide Web is one of the most challenging subjects. In this work we consider the Web from a probabilistic point of view. We analyze the relations between various characteristics of the Web. In particular, we are interested in the Web properties that affect the Web page

  15. Life Cycle Project Plan Outline: Web Sites and Web-based Applications

    Science.gov (United States)

    This tool is a guideline for planning and checking for 508 compliance on web sites and web based applications. Determine which EIT components are covered or excepted, which 508 standards and requirements apply, and how to implement them.

  16. Pembuatan Aplikasi Web Manajemen Laundry dan Integrasi Data dengan Web Service

    Directory of Open Access Journals (Sweden)

    Refika Khoirunnisa

    2016-01-01

    Full Text Available Selama ini banyak dari perusahaan di bidang jasa laundry masih menggunakan pencatatan secara manual seperti menggunakan buku, sehingga setiap data tidak terintegrasi secara waktu-nyata. Oleh sebab itu, perlu dibuat penelitian untuk merancang sebuah sistem terkomputerisasi yang dapat mempermudah pencatatan dan pengolahan data keuangan laundry. Pembuatan Aplikasi Web Manajemen Laundry menggunakan bahasa pemrograman PHP, HTML, CSS, JavaScript dan basisdata MySQL sebagai tempat penyimpanan data. Aplikasi ini merupakan aplikasi yang terintegrasi dengan aplikasi melalui sebuah teknologi yang disebut web service. Aplikasi Web Manajemen Laundry dikembangkan dengan menggunakan metode RAD (Rapid Application Development yang terdiri dari tahap perencanaan kebutuhan, proses perancangan, implementasi, dan tahap pengujian. Dari hasil penelitian dapat disimpulkan bahwa Aplikasi Web Manajemen Laundry memiliki fitur yang berfungsi untuk mempermudah pencatatan dan pengolahan data secara akurat dan waktu-nyata. Fitur-fitur utama dari aplikasi ini diantaranya adalah pengolahan data transaksi, pengeluaran, dan laporan laba/rugi. Dalam menunjang fitur-fitur utama agar dapat bekerja dengan baik maka terdapat fitur pendukung yaitu pengolahan data pelanggan dan data pengguna aplikasi. Berdasarkan pengujian dengan menggunakan metode black-box, seluruh fungsi menu yang ada dalam aplikasi web telah berhasil dan berjalan sesuai dengan kebutuhan.

  17. Antral follicle counts are strongly associated with live-birth rates after assisted reproduction, with superior treatment outcome in women with polycystic ovaries.

    Science.gov (United States)

    Holte, Jan; Brodin, Thomas; Berglund, Lars; Hadziosmanovic, Nermin; Olovsson, Matts; Bergh, Torbjörn

    2011-09-01

    To evaluate the association of antral follicle count (AFC) with in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) outcome in a large unselected cohort of patients covering the entire range of AFC. Prospective observational study. University-affiliated private infertility center. 2,092 women undergoing 4,308 IVF-ICSI cycles. AFC analyzed for associations with treatment outcome and statistically adjusted for repeated treatments and age. Pregnancy rate, live-birth rate, and stimulation outcome parameters. The AFC was log-normally distributed. Pregnancy rates and live-birth rates were positively associated with AFC in a log-linear way, leveling out above AFC ∼30. Treatment outcome was superior among women with polycystic ovaries, independent from ovulatory status. The findings were significant also after adjustment for age and number of oocytes retrieved. Pregnancy and live-birth rates are log-linearly related to AFC. Polycystic ovaries, most often excluded from studies on ovarian reserve, fit as one extreme in the spectrum of AFC; a low count constitutes the other extreme, with the lowest ovarian reserve and poor treatment outcome. The findings remained statistically significant also after adjustment for the number of oocytes retrieved, suggesting this measure of ovarian reserve comprises information on oocyte quality and not only quantity. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  18. Web Literacy, Web Literacies or Just Literacies on the Web? Reflections from a Study of Personal Homepages.

    Science.gov (United States)

    Karlsson, Anna-Malin

    2002-01-01

    Discusses the question of whether there is such a thing as web literacy. Perspectives from media studies, literacy studies, and the study of multimodal texts are used to find the main contextual parameters involved in what might be classed as web literacy. The parameters suggested are material conditions, domain, power or ideology, and semiotic…

  19. Finding Web-Based Anxiety Interventions on the World Wide Web: A Scoping Review.

    Science.gov (United States)

    Ashford, Miriam Thiel; Olander, Ellinor K; Ayers, Susan

    2016-06-01

    One relatively new and increasingly popular approach of increasing access to treatment is Web-based intervention programs. The advantage of Web-based approaches is the accessibility, affordability, and anonymity of potentially evidence-based treatment. Despite much research evidence on the effectiveness of Web-based interventions for anxiety found in the literature, little is known about what is publically available for potential consumers on the Web. Our aim was to explore what a consumer searching the Web for Web-based intervention options for anxiety-related issues might find. The objectives were to identify currently publically available Web-based intervention programs for anxiety and to synthesize and review these in terms of (1) website characteristics such as credibility and accessibility; (2) intervention program characteristics such as intervention focus, design, and presentation modes; (3) therapeutic elements employed; and (4) published evidence of efficacy. Web keyword searches were carried out on three major search engines (Google, Bing, and Yahoo-UK platforms). For each search, the first 25 hyperlinks were screened for eligible programs. Included were programs that were designed for anxiety symptoms, currently publically accessible on the Web, had an online component, a structured treatment plan, and were available in English. Data were extracted for website characteristics, program characteristics, therapeutic characteristics, as well as empirical evidence. Programs were also evaluated using a 16-point rating tool. The search resulted in 34 programs that were eligible for review. A wide variety of programs for anxiety, including specific anxiety disorders, and anxiety in combination with stress, depression, or anger were identified and based predominantly on cognitive behavioral therapy techniques. The majority of websites were rated as credible, secure, and free of advertisement. The majority required users to register and/or to pay a program access

  20. Web Dynpro ABAP for practitioners

    CERN Document Server

    Gellert, Ulrich

    2013-01-01

    Web Dynpro ABAP, a NetWeaver web application user interface tool from SAP, enables web programming connected to SAP Systems. The authors' main focus was to create a book based on their own practical experience. Each chapter includes examples which lead through the content step-by-step and enable the reader to gradually explore and grasp the Web Dynpro ABAP process. The authors explain in particular how to design Web Dynpro components, the data binding and interface methods, and the view controller methods. They also describe the other SAP NetWeaver Elements (ABAP Dictionary, Authorization) and

  1. Introduction to the world wide web.

    Science.gov (United States)

    Downes, P K

    2007-05-12

    The World Wide Web used to be nicknamed the 'World Wide Wait'. Now, thanks to high speed broadband connections, browsing the web has become a much more enjoyable and productive activity. Computers need to know where web pages are stored on the Internet, in just the same way as we need to know where someone lives in order to post them a letter. This section explains how the World Wide Web works and how web pages can be viewed using a web browser.

  2. Web traffic and firm performance

    DEFF Research Database (Denmark)

    Farooq, Omar; Aguenaou, Samir

    2013-01-01

    Does the traffic generated by websites of firms signal anything to stock market participants? Does higher web-traffic translate into availability of more information and therefore lower agency problems? And if answers to above questions are in affirmative, does higher web-traffic traffic translate...... into better firm performance? This paper aims to answer these questions by documenting a positive relationship between the extent of web-traffic and firm performance in the MENA region during the 2010. We argue that higher web-traffic lowers the agency problems in firms by disseminating more information...... to stock market participants. Consequently, lower agency problems translate into better performance. Furthermore, we also show that agency reducing role of web-traffic is more pronounced in regimes where information environment is already bad. For example, our results show stronger impact of web...

  3. Characterizing web heuristics

    NARCIS (Netherlands)

    de Jong, Menno D.T.; van der Geest, Thea

    2000-01-01

    This article is intended to make Web designers more aware of the qualities of heuristics by presenting a framework for analyzing the characteristics of heuristics. The framework is meant to support Web designers in choosing among alternative heuristics. We hope that better knowledge of the

  4. Web Publishing Schedule

    Science.gov (United States)

    Section 207(f)(2) of the E-Gov Act requires federal agencies to develop an inventory and establish a schedule of information to be published on their Web sites, make those schedules available for public comment. To post the schedules on the web site.

  5. WebPASS Explorer (HR Personnel Management)

    Data.gov (United States)

    US Agency for International Development — WebPass Explorer (WebPASS Framework): USAID is partnering with DoS in the implementation of their WebPass Post Personnel (PS) Module. WebPassPS does not replace...

  6. Programming the Mobile Web

    CERN Document Server

    Firtman, Maximiliano

    2010-01-01

    Today's market for mobile apps goes beyond the iPhone to include BlackBerry, Nokia, Windows Phone, and smartphones powered by Android, webOS, and other platforms. If you're an experienced web developer, this book shows you how to build a standard app core that you can extend to work with specific devices. You'll learn the particulars and pitfalls of building mobile apps with HTML, CSS, and other standard web tools. You'll also explore platform variations, finicky mobile browsers, Ajax design patterns for mobile, and much more. Before you know it, you'll be able to create mashups using Web 2.

  7. Creating Web Pages Simplified

    CERN Document Server

    Wooldridge, Mike

    2011-01-01

    The easiest way to learn how to create a Web page for your family or organization Do you want to share photos and family lore with relatives far away? Have you been put in charge of communication for your neighborhood group or nonprofit organization? A Web page is the way to get the word out, and Creating Web Pages Simplified offers an easy, visual way to learn how to build one. Full-color illustrations and concise instructions take you through all phases of Web publishing, from laying out and formatting text to enlivening pages with graphics and animation. This easy-to-follow visual guide sho

  8. SSWAP: A Simple Semantic Web Architecture and Protocol for semantic web services.

    Science.gov (United States)

    Gessler, Damian D G; Schiltz, Gary S; May, Greg D; Avraham, Shulamit; Town, Christopher D; Grant, David; Nelson, Rex T

    2009-09-23

    SSWAP (Simple Semantic Web Architecture and Protocol; pronounced "swap") is an architecture, protocol, and platform for using reasoning to semantically integrate heterogeneous disparate data and services on the web. SSWAP was developed as a hybrid semantic web services technology to overcome limitations found in both pure web service technologies and pure semantic web technologies. There are currently over 2400 resources published in SSWAP. Approximately two dozen are custom-written services for QTL (Quantitative Trait Loci) and mapping data for legumes and grasses (grains). The remaining are wrappers to Nucleic Acids Research Database and Web Server entries. As an architecture, SSWAP establishes how clients (users of data, services, and ontologies), providers (suppliers of data, services, and ontologies), and discovery servers (semantic search engines) interact to allow for the description, querying, discovery, invocation, and response of semantic web services. As a protocol, SSWAP provides the vocabulary and semantics to allow clients, providers, and discovery servers to engage in semantic web services. The protocol is based on the W3C-sanctioned first-order description logic language OWL DL. As an open source platform, a discovery server running at http://sswap.info (as in to "swap info") uses the description logic reasoner Pellet to integrate semantic resources. The platform hosts an interactive guide to the protocol at http://sswap.info/protocol.jsp, developer tools at http://sswap.info/developer.jsp, and a portal to third-party ontologies at http://sswapmeet.sswap.info (a "swap meet"). SSWAP addresses the three basic requirements of a semantic web services architecture (i.e., a common syntax, shared semantic, and semantic discovery) while addressing three technology limitations common in distributed service systems: i.e., i) the fatal mutability of traditional interfaces, ii) the rigidity and fragility of static subsumption hierarchies, and iii) the

  9. Web 2.1 : Toward a large and qualitative participation on the Web

    Directory of Open Access Journals (Sweden)

    Boubker Sbihi

    2009-06-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 This article presents the results of research done on Web 2.0 within the School of Information Sciences ESI. It aims to study the behavior of different academic actors who deal with information, among whom we cite teachers, students of masters and students of information sciences in Morocco, face to Web 2.0’s services. Firstly, it aims to evaluate the use and production of information in the context of Web 2.0. Then, it   attempts to assess those rates, to identify and analyze the causes of eventual problems and obstacles that academic actors face.  In fact, we intend to understand why information actors in the academic world use often Web 2.0’s services but do rarely produce qualitative content. To achieve the objectives set, we used the on-site survey method, which was based on an electronic questionnaire administered directly to our people via the Internet. We chose the electronic version of questionnaire in order to make an optimal use in terms of new technologies, to gain time and to reduce cost. Then, in order to deepen the understanding of the data collected, we complete the data collected by the questionnaire by an ongoing discussions with actors. Finally, to overcome the problems already identified, we intend to propose the elements of a new version of the Web called Web 2.1 offering new concepts   in order to encourage users to produce information of quality and make the Web more open to a larger community. This version maintains the current contents of   Web 2.0 and adds more value to it. Indeed, the content will be monitored, evaluated and validated before being published. In order to target valuable information, the new version of Web 2.1 proposes to categorize users into three groups: users who just use the contents, producers who use and produce content, and  validators  who validate the content in order to  target information that is validated and of good

  10. Desarrollo de aplicaciones web

    OpenAIRE

    Luján Mora, Sergio

    2010-01-01

    Agradecimientos 1. Introducción a las aplicaciones web 2. Instalación del servidor 3. Diseño de páginas web 4. Formato estructurado de texto: XML 5. Contenido dinámico 6. Acceso a bases de datos: JDBC 7. Servicios web 8. Utilización y mantenimiento 9. Monitorización y análisis Bibliografía GNU Free Documentation License

  11. Evaluation of WebEase: An Epilepsy Self-Management Web Site

    Science.gov (United States)

    DiIorio, Colleen; Escoffery, Cam; McCarty, Frances; Yeager, Katherine A.; Henry, Thomas R.; Koganti, Archana; Reisinger, Elizabeth L.; Wexler, Bethany

    2009-01-01

    People with epilepsy have various education needs and must adopt many self-management behaviors in order to control their condition. This study evaluates WebEase, an Internet-based, theory-driven, self-management program for adults with epilepsy. Thirty-five participants took part in a 6-week pilot implementation of WebEase. The main components of…

  12. RESTful web services with Dropwizard

    CERN Document Server

    Dallas, Alexandros

    2014-01-01

    A hands-on focused step-by-step tutorial to help you create Web Service applications using Dropwizard. If you are a software engineer or a web developer and want to learn more about building your own Web Service application, then this is the book for you. Basic knowledge of Java and RESTful Web Service concepts is assumed and familiarity with SQL/MySQL and command-line scripting would be helpful.

  13. Segmenting The Web 2.0 Market: Behavioural And Usage Patterns Of Social Web Consumers

    NARCIS (Netherlands)

    Lorenzo Romero, Carlota; Constantinides, Efthymios; Alarcon-del-Amo, Maria-del-Carmen

    2010-01-01

    The evolution of the commercial Internet to the current phase, commonly called Web 2.0 (or Social Web) has firmly positioned the web not only as a commercial but also as a social communication platform: an online environment facilitating peer-to-peer interaction, socialization, co-operation and

  14. System configuration on Web with mashup.

    OpenAIRE

    清水, 宏泰; SHIMIZU, Hiroyasu

    2014-01-01

    Mashup become trend for create Web service due to popularizing cloud service. Mashup is method for create Web service from several Web services and API. Mashup has a few problems. One of the problem is deference of data format and label. Semantic Web can solve it. This paper propose method of building a system on Web with mashup using semantic Web. Mashup system configuration can express as URL. So, editing URL for mashup is editing system configuration. And any device can use this system on ...

  15. Trust estimation of the semantic web using semantic web clustering

    Science.gov (United States)

    Shirgahi, Hossein; Mohsenzadeh, Mehran; Haj Seyyed Javadi, Hamid

    2017-05-01

    Development of semantic web and social network is undeniable in the Internet world these days. Widespread nature of semantic web has been very challenging to assess the trust in this field. In recent years, extensive researches have been done to estimate the trust of semantic web. Since trust of semantic web is a multidimensional problem, in this paper, we used parameters of social network authority, the value of pages links authority and semantic authority to assess the trust. Due to the large space of semantic network, we considered the problem scope to the clusters of semantic subnetworks and obtained the trust of each cluster elements as local and calculated the trust of outside resources according to their local trusts and trust of clusters to each other. According to the experimental result, the proposed method shows more than 79% Fscore that is about 11.9% in average more than Eigen, Tidal and centralised trust methods. Mean of error in this proposed method is 12.936, that is 9.75% in average less than Eigen and Tidal trust methods.

  16. MedlinePlus Connect: Web Service

    Science.gov (United States)

    ... MedlinePlus Connect → Web Service URL of this page: https://medlineplus.gov/connect/service.html MedlinePlus Connect: Web ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

  17. MedlinePlus Connect: Web Application

    Science.gov (United States)

    ... MedlinePlus Connect → Web Application URL of this page: https://medlineplus.gov/connect/application.html MedlinePlus Connect: Web ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

  18. SPADOCK: Adaptive Pipeline Technology for Web System using WebSocket

    Directory of Open Access Journals (Sweden)

    Aries RICHI

    2013-01-01

    Full Text Available As information technology grows to the era of IoT(Internet of Things and cloud computing, the performance ofweb application and web service which acts as the informationgateway becomes an issue. Horizontal quality of serviceimprovement through system performance escalation becomesan issue pursued by engineers and scientists, giving birth toBigPipe pipeline technology which was developed by Facebook.We make SPADOCK, an adaptive pipeline system which is builtunder distributed system architecture with the utilization ofHTML5 WebSocket, then measure its performance. Parametersused for the measurement includes latency, workload, andbandwidth. The result shows that SPADOCK could reduceserving latency by 68.28% compared with the conventional web,and it is 20.63% faster than BigPipe.

  19. WebQuest y anotaciones semánticas WebQuest and semantic annotations

    Directory of Open Access Journals (Sweden)

    Santiago Blanco Suárez

    2007-03-01

    Full Text Available En este artículo se presenta un sistema de búsqueda y recuperación de metadatos de actividades educativas que siguen el modelo WebQuest. Se trata de una base de datos relacional, accesible a través del web, que se complementa con un módulo que permite realizar anotaciones semánticas y cuyo objetivo es capturar y enriquecer el conocimiento acerca del uso de dichos ejercicios por parte de la comunidad de docentes que experimentan con ellos, así como documentar los recursos o sitios web de interés didáctico buscando construir un repositorio de enlaces educativos de calidad. This paper presents a system of searching and recovering educational activities that follow the Web-Quest model through the web, complemented with a module to make semantic annotations aimed at getting and enriching the knowledge on the use of these exercises by the teaching community. It also tries to document the resources or websites with didactic interest in order to build a qualified account of educational links.

  20. Historical Network Analysis of the Web

    DEFF Research Database (Denmark)

    Brügger, Niels

    2013-01-01

    This article discusses some of the fundamental methodological challenges related to doing historical network analyses of the web based on material in web archives. Since the late 1990s many countries have established extensive national web archives, and software supported network analysis...... of the online web has for a number of years gained currency within Internet studies. However, the combination of these two phenomena—historical network analysis of material in web archives—can at best be characterized as an emerging new area of study. Most of the methodological challenges within this new area...... revolve around the specific nature of archived web material. On the basis of an introduction to the processes involved in web archiving as well as of the characteristics of archived web material, the article outlines and scrutinizes some of the major challenges which may arise when doing network analysis...

  1. Web corpus construction

    CERN Document Server

    Schafer, Roland

    2013-01-01

    The World Wide Web constitutes the largest existing source of texts written in a great variety of languages. A feasible and sound way of exploiting this data for linguistic research is to compile a static corpus for a given language. There are several adavantages of this approach: (i) Working with such corpora obviates the problems encountered when using Internet search engines in quantitative linguistic research (such as non-transparent ranking algorithms). (ii) Creating a corpus from web data is virtually free. (iii) The size of corpora compiled from the WWW may exceed by several orders of magnitudes the size of language resources offered elsewhere. (iv) The data is locally available to the user, and it can be linguistically post-processed and queried with the tools preferred by her/him. This book addresses the main practical tasks in the creation of web corpora up to giga-token size. Among these tasks are the sampling process (i.e., web crawling) and the usual cleanups including boilerplate removal and rem...

  2. Hera : Development of semantic web information systems

    NARCIS (Netherlands)

    Houben, G.J.P.M.; Barna, P.; Frasincar, F.; Vdovják, R.; Cuella Lovelle, J.M.; et al., xx

    2003-01-01

    As a consequence of the success of the Web, methodologies for information system development need to consider systems that use the Web paradigm. These Web Information Systems (WIS) use Web technologies to retrieve information from the Web and to deliver information in a Web presentation to the

  3. Answering the Call of the Web: UVA Crafts a Innovative Web Certification Program for Its Staff.

    Science.gov (United States)

    Lee, Sandra T.

    2000-01-01

    Describes the development of a Web Certification Program at the University of Virginia. This program offers certificates at three levels: Web Basics, Web Designer, and Web Master. The paper focuses on: determination of criteria for awarding certificates; program status; program evaluation and program effectiveness; and future plans for the Web…

  4. WebCN: A web-based computation tool for in situ-produced cosmogenic nuclides

    Energy Technology Data Exchange (ETDEWEB)

    Ma Xiuzeng [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States)]. E-mail: hongju@purdue.edu; Li Yingkui [Department of Geography, University of Missouri-Columbia, Columbia, MO 65211 (United States); Bourgeois, Mike [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Caffee, Marc [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Elmore, David [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Granger, Darryl [Department of Earth and Atmospheric Sciences, Purdue University, West Lafayette, IN 47907 (United States); Muzikar, Paul [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Smith, Preston [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States)

    2007-06-15

    Cosmogenic nuclide techniques are increasingly being utilized in geoscience research. For this it is critical to establish an effective, easily accessible and well defined tool for cosmogenic nuclide computations. We have been developing a web-based tool (WebCN) to calculate surface exposure ages and erosion rates based on the nuclide concentrations measured by the accelerator mass spectrometry. WebCN for {sup 10}Be and {sup 26}Al has been finished and published at http://www.physics.purdue.edu/primelab/for{sub u}sers/rockage.html. WebCN for {sup 36}Cl is under construction. WebCN is designed as a three-tier client/server model and uses the open source PostgreSQL for the database management and PHP for the interface design and calculations. On the client side, an internet browser and Microsoft Access are used as application interfaces to access the system. Open Database Connectivity is used to link PostgreSQL and Microsoft Access. WebCN accounts for both spatial and temporal distributions of the cosmic ray flux to calculate the production rates of in situ-produced cosmogenic nuclides at the Earth's surface.

  5. Web 3.0: implicaciones educativas

    OpenAIRE

    Grupo TACE. Tecnologías Aplicadas a las Ciencias de la Educación

    2012-01-01

    La Web 3.0 se considera la etapa que sigue a la Web 2.0 o Web social. Todavía no es un término unívoco y suele aparecer unido con la web semántica. Es una extensión del World Wide Web, que permite expresar el lenguaje natural y también utilizar un lenguaje que se puede entender, interpretar y utilizar por agentes software, permitiendo encontrar, compartir e integrar la información más fácilmente. Se trata de un nuevo ciclo en el que la inteligencia artificial se combina con la capacidad de l...

  6. Arrangement for selectively irradiating webs

    International Nuclear Information System (INIS)

    Ihme, B.

    1975-01-01

    The arrangement for selectively irradiating a web includes a perforated band of a radiation impermeable substance which is guided in an endless path via a pair of guide rollers and has two juxtaposed runs in this path. A take-up roller conveys a web of material past one of the runs at a side thereof remote from the other run, the direction of movement of the web being other than parallel to that of the band and, preferably, normal thereto. An electron accelerator is provided at the far side of the run remote from the web and is effective for directing a radiation beam at the web through the perforations

  7. Determining the signalling overhead of two common WebRTC methods:JSON via XMLHttpRequest and SIP over WebSocket

    CSIR Research Space (South Africa)

    Adeyeye, M

    2013-09-01

    Full Text Available Web Real-Time Communication (WebRTC) introduces real-time multimedia communication as native capabilities of Web browsers. With the adoption of WebRTC the Web browsers will be able to use WebRTC to communicate with one another (peer...

  8. Anonymous Web Browsing and Hosting

    OpenAIRE

    MANOJ KUMAR; ANUJ RANI

    2013-01-01

    In today’s high tech environment every organization, individual computer users use internet for accessing web data. To maintain high confidentiality and security of the data secure web solutions are required. In this paper we described dedicated anonymous web browsing solutions which makes our browsing faster and secure. Web application which play important role for transferring our secret information including like email need more and more security concerns. This paper also describes that ho...

  9. EuroGOV: Engineering a Multilingual Web Corpus

    NARCIS (Netherlands)

    Sigurbjörnsson, B.; Kamps, J.; de Rijke, M.

    2005-01-01

    EuroGOV is a multilingual web corpus that was created to serve as the document collection for WebCLEF, the CLEF 2005 web retrieval task. EuroGOV is a collection of web pages crawled from the European Union portal, European Union member state governmental web sites, and Russian government web sites.

  10. Data management on the spatial web

    DEFF Research Database (Denmark)

    Jensen, Christian S.

    2012-01-01

    Due in part to the increasing mobile use of the web and the proliferation of geo-positioning, the web is fast acquiring a significant spatial aspect. Content and users are being augmented with locations that are used increasingly by location-based services. Studies suggest that each week, several...... billion web queries are issued that have local intent and target spatial web objects. These are points of interest with a web presence, and they thus have locations as well as textual descriptions. This development has given prominence to spatial web data management, an area ripe with new and exciting...... opportunities and challenges. The research community has embarked on inventing and supporting new query functionality for the spatial web. Different kinds of spatial web queries return objects that are near a location argument and are relevant to a text argument. To support such queries, it is important...

  11. APFEL Web a web-based application for the graphical visualization of parton distribution functions

    CERN Document Server

    Carrazza, Stefano; Palazzo, Daniele; Rojo, Juan

    2015-01-01

    We present APFEL Web, a web-based application designed to provide a flexible user-friendly tool for the graphical visualization of parton distribution functions (PDFs). In this note we describe the technical design of the APFEL Web application, motivating the choices and the framework used for the development of this project. We document the basic usage of APFEL Web and show how it can be used to provide useful input for a variety of collider phenomenological studies. Finally we provide some examples showing the output generated by the application.

  12. APFEL Web: a web-based application for the graphical visualization of parton distribution functions

    International Nuclear Information System (INIS)

    Carrazza, Stefano; Ferrara, Alfio; Palazzo, Daniele; Rojo, Juan

    2015-01-01

    We present APFEL Web, a Web-based application designed to provide a flexible user-friendly tool for the graphical visualization of parton distribution functions. In this note we describe the technical design of the APFEL Web application, motivating the choices and the framework used for the development of this project. We document the basic usage of APFEL Web and show how it can be used to provide useful input for a variety of collider phenomenological studies. Finally we provide some examples showing the output generated by the application. (note)

  13. The Evolution of Web Searching.

    Science.gov (United States)

    Green, David

    2000-01-01

    Explores the interrelation between Web publishing and information retrieval technologies and lists new approaches to Web indexing and searching. Highlights include Web directories; search engines; portalisation; Internet service providers; browser providers; meta search engines; popularity based analysis; natural language searching; links-based…

  14. WebPresent: a World Wide Web-based telepresentation tool for physicians

    Science.gov (United States)

    Sampath-Kumar, Srihari; Banerjea, Anindo; Moshfeghi, Mehran

    1997-05-01

    In this paper, we present the design architecture and the implementation status of WebPresent - a world wide web based tele-presentation tool. This tool allows a physician to use a conference server workstation and make a presentation of patient cases to a geographically distributed audience. The audience consists of other physicians collaborating on patients' health care management and physicians participating in continuing medical education. These physicians are at several locations with networks of different bandwidth and capabilities connecting them. Audiences also receive the patient case information on different computers ranging form high-end display workstations to laptops with low-resolution displays. WebPresent is a scalable networked multimedia tool which supports the presentation of hypertext, images, audio, video, and a white-board to remote physicians with hospital Intranet access. WebPresent allows the audience to receive customized information. The data received can differ in resolution and bandwidth, depending on the availability of resources such as display resolution and network bandwidth.

  15. Elements of a Spatial Web

    DEFF Research Database (Denmark)

    Jensen, Christian S.

    2010-01-01

    Driven by factors such as the increasingly mobile use of the web and the proliferation of geo-positioning technologies, the web is rapidly acquiring a spatial aspect. Specifically, content and users are being geo-tagged, and services are being developed that exploit these tags. The research...... community is hard at work inventing means of efficiently supporting new spatial query functionality. Points of interest with a web presence, called spatial web objects, have a location as well as a textual description. Spatio-textual queries return such objects that are near a location argument...... and are relevant to a text argument. An important element in enabling such queries is to be able to rank spatial web objects. Another is to be able to determine the relevance of an object to a query. Yet another is to enable the efficient processing of such queries. The talk covers recent results on spatial web...

  16. WEB-IS2: Next Generation Web Services Using Amira Visualization Package

    Science.gov (United States)

    Yang, X.; Wang, Y.; Bollig, E. F.; Kadlec, B. J.; Garbow, Z. A.; Yuen, D. A.; Erlebacher, G.

    2003-12-01

    Amira (www.amiravis.com) is a powerful 3-D visualization package and has been employed recently by the science and engineering communities to gain insight into their data. We present a new web-based interface to Amira, packaged in a Java applet. We have developed a module called WEB-IS/Amira (WEB-IS2), which provides web-based access to Amira. This tool allows earth scientists to manipulate Amira controls remotely and to analyze, render and view large datasets over the internet, without regard for time or location. This could have important ramifications for GRID computing. The design of our implementation will soon allow multiple users to visually collaborate by manipulating a single dataset through a variety of client devices. These clients will only require a browser capable of displaying Java applets. As the deluge of data continues, innovative solutions that maximize ease of use without sacrificing efficiency or flexibility will continue to gain in importance, particularly in the Earth sciences. Major initiatives, such as Earthscope (http://www.earthscope.org), which will generate at least a terabyte of data daily, stand to profit enormously by a system such as WEB-IS/Amira (WEB-IS2). We discuss our use of SOAP (Livingston, D., Advanced SOAP for Web development, Prentice Hall, 2002), a novel 2-way communication protocol, as a means of providing remote commands, and efficient point-to-point transfer of binary image data. We will present our initial experiences with the use of Naradabrokering (www.naradabrokering.org) as a means to decouple clients and servers. Information is submitted to the system as a published item, while it is retrieved through a subscription mechanisms, via what is known as "topics". These topic headers, their contents, and the list of subscribers are automatically tracked by Naradabrokering. This novel approach promises a high degree of fault tolerance, flexibility with respect to client diversity, and language independence for the

  17. WebDMS: A Web-Based Data Management System for Environmental Data

    Science.gov (United States)

    Ekstrand, A. L.; Haderman, M.; Chan, A.; Dye, T.; White, J. E.; Parajon, G.

    2015-12-01

    DMS is an environmental Data Management System to manage, quality-control (QC), summarize, document chain-of-custody, and disseminate data from networks ranging in size from a few sites to thousands of sites, instruments, and sensors. The server-client desktop version of DMS is used by local and regional air quality agencies (including the Bay Area Air Quality Management District, the South Coast Air Quality Management District, and the California Air Resources Board), the EPA's AirNow Program, and the EPA's AirNow-International (AirNow-I) program, which offers countries the ability to run an AirNow-like system. As AirNow's core data processing engine, DMS ingests, QCs, and stores real-time data from over 30,000 active sensors at over 5,280 air quality and meteorological sites from over 130 air quality agencies across the United States. As part of the AirNow-I program, several instances of DMS are deployed in China, Mexico, and Taiwan. The U.S. Department of State's StateAir Program also uses DMS for five regions in China and plans to expand to other countries in the future. Recent development has begun to migrate DMS from an onsite desktop application to WebDMS, a web-based application designed to take advantage of cloud hosting and computing services to increase scalability and lower costs. WebDMS will continue to provide easy-to-use data analysis tools, such as time-series graphs, scatterplots, and wind- or pollution-rose diagrams, as well as allowing data to be exported to external systems such as the EPA's Air Quality System (AQS). WebDMS will also provide new GIS analysis features and a suite of web services through a RESTful web API. These changes will better meet air agency needs and allow for broader national and international use (for example, by the AirNow-I partners). We will talk about the challenges and advantages of migrating DMS to the web, modernizing the DMS user interface, and making it more cost-effective to enhance and maintain over time.

  18. Security scanning of Web sites at CERN

    CERN Multimedia

    IT Department

    2010-01-01

    As of early 2010, the CERN Computer Security Team will start regular scanning of all Web sites and Web applications at CERN, visible on the Internet, or on the General Purpose Network (office network). The goal of this scanning is to improve the quality of CERN Web sites. All deficits found will be reported by e-mail to the relevant Web site owners, and must be fixed in a timely manner. Web site owners may also request one-off scans of their Web site or Web application, by sending an e-mail to Computer.Security@cern.ch. These Web scans are designed to limit the impact on the scanned Web sites. Nevertheless, in very rare cases scans may cause undesired side-effects, e.g. generate a large number of log entries, or cause particularly badly designed or less robust Web applications to crash. If a Web site is affected by these security scans, it will also be susceptible to any more aggressive scan that can be performed any time by a malicious attacker. Such Web applications should be fixed, and also additionally...

  19. XML databases and the semantic web

    CERN Document Server

    Thuraisingham, Bhavani

    2002-01-01

    Efficient access to data, sharing data, extracting information from data, and making use of the information have become urgent needs for today''s corporations. With so much data on the Web, managing it with conventional tools is becoming almost impossible. New tools and techniques are necessary to provide interoperability as well as warehousing between multiple data sources and systems, and to extract information from the databases. XML Databases and the Semantic Web focuses on critical and new Web technologies needed for organizations to carry out transactions on the Web, to understand how to use the Web effectively, and to exchange complex documents on the Web.This reference for database administrators, database designers, and Web designers working in tandem with database technologists covers three emerging technologies of significant impact for electronic business: Extensible Markup Language (XML), semi-structured databases, and the semantic Web. The first two parts of the book explore these emerging techn...

  20. Exploring the academic invisible web

    OpenAIRE

    Lewandowski, Dirk; Mayr, Philipp

    2006-01-01

    Purpose: To provide a critical review of Bergman’s 2001 study on the Deep Web. In addition, we bring a new concept into the discussion, the Academic Invisible Web (AIW). We define the Academic Invisible Web as consisting of all databases and collections relevant to academia but not searchable by the general-purpose internet search engines. Indexing this part of the Invisible Web is central to scientific search engines. We provide an overview of approaches followed thus far. Design/methodol...

  1. Web Team Development

    Science.gov (United States)

    Church, Jennifer; Felker, Kyle

    2005-01-01

    The dynamic world of the Web has provided libraries with a wealth of opportunities, including new approaches to the provision of information and varied internal staffing structures. The development of self-managed Web teams, endowed with authority and resources, can create an adaptable and responsive culture within libraries. This new working team…

  2. Augmenting the Web through Open Hypermedia

    DEFF Research Database (Denmark)

    Bouvin, N.O.

    2003-01-01

    Based on an overview of Web augmentation and detailing the three basic approaches to extend the hypermedia functionality of the Web, the author presents a general open hypermedia framework (the Arakne framework) to augment the Web. The aim is to provide users with the ability to link, annotate, a......, and otherwise structure Web pages, as they see fit. The paper further discusses the possibilities of the concept through the description of various experiments performed with an implementation of the framework, the Arakne Environment......Based on an overview of Web augmentation and detailing the three basic approaches to extend the hypermedia functionality of the Web, the author presents a general open hypermedia framework (the Arakne framework) to augment the Web. The aim is to provide users with the ability to link, annotate...

  3. Personalization of Rule-based Web Services.

    Science.gov (United States)

    Choi, Okkyung; Han, Sang Yong

    2008-04-04

    Nowadays Web users have clearly expressed their wishes to receive personalized services directly. Personalization is the way to tailor services directly to the immediate requirements of the user. However, the current Web Services System does not provide any features supporting this such as consideration of personalization of services and intelligent matchmaking. In this research a flexible, personalized Rule-based Web Services System to address these problems and to enable efficient search, discovery and construction across general Web documents and Semantic Web documents in a Web Services System is proposed. This system utilizes matchmaking among service requesters', service providers' and users' preferences using a Rule-based Search Method, and subsequently ranks search results. A prototype of efficient Web Services search and construction for the suggested system is developed based on the current work.

  4. Web Services--A Buzz Word with Potentials

    Science.gov (United States)

    János T. Füstös

    2006-01-01

    The simplest definition of a web service is an application that provides a web API. The web API exposes the functionality of the solution to other applications. The web API relies on other Internet-based technologies to manage communications. The resulting web services are pervasive, vendor-independent, language-neutral, and very low-cost. The main purpose of a web API...

  5. Web-based Surveys: Changing the Survey Process

    OpenAIRE

    Gunn, Holly

    2002-01-01

    Web-based surveys are having a profound influence on the survey process. Unlike other types of surveys, Web page design skills and computer programming expertise play a significant role in the design of Web-based surveys. Survey respondents face new and different challenges in completing a Web-based survey. This paper examines the different types of Web-based surveys, the advantages and challenges of using Web-based surveys, the design of Web-based surveys, and the issues of validity, error, ...

  6. A Runtime System for Interactive Web Services

    DEFF Research Database (Denmark)

    Brabrand, Claus; Møller, Anders; Sandholm, Anders

    1999-01-01

    Interactive web services are increasingly replacing traditional static web pages. Producing web services seems to require a tremendous amount of laborious low-level coding due to the primitive nature of CGI programming. We present ideas for an improved runtime system for interactive web services ...... built on top of CGI running on virtually every combination of browser and HTTP/CGI server. The runtime system has been implemented and used extensively in , a tool for producing interactive web services.......Interactive web services are increasingly replacing traditional static web pages. Producing web services seems to require a tremendous amount of laborious low-level coding due to the primitive nature of CGI programming. We present ideas for an improved runtime system for interactive web services...

  7. Extracting Macroscopic Information from Web Links.

    Science.gov (United States)

    Thelwall, Mike

    2001-01-01

    Discussion of Web-based link analysis focuses on an evaluation of Ingversen's proposed external Web Impact Factor for the original use of the Web, namely the interlinking of academic research. Studies relationships between academic hyperlinks and research activities for British universities and discusses the use of search engines for Web link…

  8. The Semantic Web in Teacher Education

    Science.gov (United States)

    Czerkawski, Betül Özkan

    2014-01-01

    The Semantic Web enables increased collaboration among computers and people by organizing unstructured data on the World Wide Web. Rather than a separate body, the Semantic Web is a functional extension of the current Web made possible by defining relationships among websites and other online content. When explicitly defined, these relationships…

  9. Hacking web intelligence open source intelligence and web reconnaissance concepts and techniques

    CERN Document Server

    Chauhan, Sudhanshu

    2015-01-01

    Open source intelligence (OSINT) and web reconnaissance are rich topics for infosec professionals looking for the best ways to sift through the abundance of information widely available online. In many cases, the first stage of any security assessment-that is, reconnaissance-is not given enough attention by security professionals, hackers, and penetration testers. Often, the information openly present is as critical as the confidential data. Hacking Web Intelligence shows you how to dig into the Web and uncover the information many don't even know exists. The book takes a holistic approach

  10. Designing a responsive web site

    OpenAIRE

    Fejzić , Diana

    2016-01-01

    Due to the increasing prevalence of smartphones and tablet computers design became a crucial part of web design. For a user, responsive web design enables the best user experience, regardless of whether a user is visiting the site via a mobile phone, a tablet or a computer. This thesis covers the process of planning, designing and responsive web site development, for a fictitious company named “Creative Design d.o.o.”, with the help of web technologies. In the initial part of the thesis, w...

  11. WebBio, a web-based management and analysis system for patient data of biological products in hospital.

    Science.gov (United States)

    Lu, Ying-Hao; Kuo, Chen-Chun; Huang, Yaw-Bin

    2011-08-01

    We selected HTML, PHP and JavaScript as the programming languages to build "WebBio", a web-based system for patient data of biological products and used MySQL as database. WebBio is based on the PHP-MySQL suite and is run by Apache server on Linux machine. WebBio provides the functions of data management, searching function and data analysis for 20 kinds of biological products (plasma expanders, human immunoglobulin and hematological products). There are two particular features in WebBio: (1) pharmacists can rapidly find out whose patients used contaminated products for medication safety, and (2) the statistics charts for a specific product can be automatically generated to reduce pharmacist's work loading. WebBio has successfully turned traditional paper work into web-based data management.

  12. A Semantically Automated Protocol Adapter for Mapping SOAP Web Services to RESTful HTTP Format to Enable the Web Infrastructure, Enhance Web Service Interoperability and Ease Web Service Migration

    Directory of Open Access Journals (Sweden)

    Frank Doheny

    2012-04-01

    Full Text Available Semantic Web Services (SWS are Web Service (WS descriptions augmented with semantic information. SWS enable intelligent reasoning and automation in areas such as service discovery, composition, mediation, ranking and invocation. This paper applies SWS to a previous protocol adapter which, operating within clearly defined constraints, maps SOAP Web Services to RESTful HTTP format. However, in the previous adapter, the configuration element is manual and the latency implications are locally based. This paper applies SWS technologies to automate the configuration element and the latency tests are conducted in a more realistic Internet based setting.

  13. USING WEB MINING IN E-COMMERCE APPLICATIONS

    Directory of Open Access Journals (Sweden)

    Claudia Elena Dinucă

    2011-09-01

    Full Text Available Nowadays, the web is an important part of our daily life. The web is now the best medium of doing business. Large companies rethink their business strategy using the web to improve business. Business carried on the Web offers the opportunity to potential customers or partners where their products and specific business can be found. Business presence through a company web site has several advantages as it breaks the barrier of time and space compared with the existence of a physical office. To differentiate through the Internet economy, winning companies have realized that e-commerce transactions is more than just buying / selling, appropriate strategies are key to improve competitive power. One effective technique used for this purpose is data mining. Data mining is the process of extracting interesting knowledge from data. Web mining is the use of data mining techniques to extract information from web data. This article presents the three components of web mining: web usage mining, web structure mining and web content mining.

  14. A Typology for Web 2.0

    DEFF Research Database (Denmark)

    Dalsgaard, Christian; Sorensen, Elsebeth Korsgaard

    2008-01-01

    of a learning environment: 1) organizing communicative processes and 2) organizing resources. Organizing communicative processes is supported by Web 2.0’s ability to provide a range of communicative tools that can be organized flexibly by students. Web 2.0 provides opportunities for communities and groups...... to organize their own communicative processes. Further, Web 2.0 supports organization of resources by empowering students to create, construct, manage and share content themselves. However, the main potential lies within collaborative creation and sharing in networks. Potentially, networking tools......Web 2.0 is a term used to describe recent developments on the World Wide Web. The term is often used to describe the increased use of the web for user-generated content, collaboration, and social networking. However, Web 2.0 is a weakly defined concept, and it is unclear exactly what kind...

  15. Sensor system for web inspection

    Science.gov (United States)

    Sleefe, Gerard E.; Rudnick, Thomas J.; Novak, James L.

    2002-01-01

    A system for electrically measuring variations over a flexible web has a capacitive sensor including spaced electrically conductive, transmit and receive electrodes mounted on a flexible substrate. The sensor is held against a flexible web with sufficient force to deflect the path of the web, which moves relative to the sensor.

  16. Chemical Search Web Utility

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Chemical Search Web Utility is an intuitive web application that allows the public to easily find the chemical that they are interested in using, and which...

  17. Nuclear expert web search and crawler algorithm

    International Nuclear Information System (INIS)

    Reis, Thiago; Barroso, Antonio C.O.; Baptista, Benedito Filho D.

    2013-01-01

    In this paper we present preliminary research on web search and crawling algorithm applied specifically to nuclear-related web information. We designed a web-based nuclear-oriented expert system guided by a web crawler algorithm and a neural network able to search and retrieve nuclear-related hyper textual web information in autonomous and massive fashion. Preliminary experimental results shows a retrieval precision of 80% for web pages related to any nuclear theme and a retrieval precision of 72% for web pages related only to nuclear power theme. (author)

  18. Nuclear expert web search and crawler algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Thiago; Barroso, Antonio C.O.; Baptista, Benedito Filho D., E-mail: thiagoreis@usp.br, E-mail: barroso@ipen.br, E-mail: bdbfilho@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In this paper we present preliminary research on web search and crawling algorithm applied specifically to nuclear-related web information. We designed a web-based nuclear-oriented expert system guided by a web crawler algorithm and a neural network able to search and retrieve nuclear-related hyper textual web information in autonomous and massive fashion. Preliminary experimental results shows a retrieval precision of 80% for web pages related to any nuclear theme and a retrieval precision of 72% for web pages related only to nuclear power theme. (author)

  19. Collaborative web hosting challenges and research directions

    CERN Document Server

    Ahmed, Reaz

    2014-01-01

    This brief presents a peer-to-peer (P2P) web-hosting infrastructure (named pWeb) that can transform networked, home-entertainment devices into lightweight collaborating Web servers for persistently storing and serving multimedia and web content. The issues addressed include ensuring content availability, Plexus routing and indexing, naming schemes, web ID, collaborative web search, network architecture and content indexing. In pWeb, user-generated voluminous multimedia content is proactively uploaded to a nearby network location (preferably within the same LAN or at least, within the same ISP)

  20. Web Design Matters

    Science.gov (United States)

    Mathews, Brian

    2009-01-01

    The web site is a library's most important feature. Patrons use the web site for numerous functions, such as renewing materials, placing holds, requesting information, and accessing databases. The homepage is the place they turn to look up the hours, branch locations, policies, and events. Whether users are at work, at home, in a building, or on…

  1. Editorial for the special issue on "The Semantic Web for all" of the Semantic Web Journal (SWJ)

    NARCIS (Netherlands)

    Guéret, Christophe; Boyera, Stephane; Powell, Mike; Murillo, Martin

    2014-01-01

    Over the past few years Semantic Web technologies have brought significant changes in the way structured data is published, shared and consumed on the Web. Emerging online applications based on the Web of Objects or Linked Open Data can use the Web as a platform to exchange and reason over

  2. Web metrics for library and information professionals

    CERN Document Server

    Stuart, David

    2014-01-01

    This is a practical guide to using web metrics to measure impact and demonstrate value. The web provides an opportunity to collect a host of different metrics, from those associated with social media accounts and websites to more traditional research outputs. This book is a clear guide for library and information professionals as to what web metrics are available and how to assess and use them to make informed decisions and demonstrate value. As individuals and organizations increasingly use the web in addition to traditional publishing avenues and formats, this book provides the tools to unlock web metrics and evaluate the impact of this content. The key topics covered include: bibliometrics, webometrics and web metrics; data collection tools; evaluating impact on the web; evaluating social media impact; investigating relationships between actors; exploring traditional publications in a new environment; web metrics and the web of data; the future of web metrics and the library and information professional.Th...

  3. SproutCore web application development

    CERN Document Server

    Keating, Tyler

    2013-01-01

    Written as a practical, step-by-step tutorial, Creating HTML5 Apps with SproutCore is full of engaging examples to help you learn in a practical context.This book is for any person looking to write software for the Web or already writing software for the Web. Whether your background is in web development or in software development, Creating HTML5 Apps with SproutCore will help you expand your skills so that you will be ready to apply the software development principles in the web development space.

  4. Vibration transmission through sheet webs of hobo spiders (Eratigena agrestis) and tangle webs of western black widow spiders (Latrodectus hesperus).

    Science.gov (United States)

    Vibert, Samantha; Scott, Catherine; Gries, Gerhard

    2016-11-01

    Web-building spiders construct their own vibratory signaling environments. Web architecture should affect signal design, and vice versa, such that vibratory signals are transmitted with a minimum of attenuation and degradation. However, the web is the medium through which a spider senses both vibratory signals from courting males and cues produced by captured prey. Moreover, webs function not only in vibration transmission, but also in defense from predators and the elements. These multiple functions may impose conflicting selection pressures on web design. We investigated vibration transmission efficiency and accuracy through two web types with contrasting architectures: sheet webs of Eratigena agrestis (Agelenidae) and tangle webs of Latrodectus hesperus (Theridiidae). We measured vibration transmission efficiencies by playing frequency sweeps through webs with a piezoelectric vibrator and a loudspeaker, recording the resulting web vibrations at several locations on each web using a laser Doppler vibrometer. Transmission efficiencies through both web types were highly variable, with within-web variation greater than among-web variation. There was little difference in transmission efficiencies of longitudinal and transverse vibrations. The inconsistent transmission of specific frequencies through webs suggests that parameters other than frequency are most important in allowing these spiders to distinguish between vibrations of prey and courting males.

  5. Process-aware web programming with Jolie

    DEFF Research Database (Denmark)

    Montesi, F.

    2016-01-01

    We extend the Jolie programming language to capture the native modelling of process-aware web information systems, i.e., web information systems based upon the execution of business processes. Our main contribution is to offer a unifying approach for the programming of distributed architectures...... on the web, which can capture web servers, stateful process execution, and the composition of services via mediation. We discuss applications of this approach through a series of examples that cover, e.g., static content serving, multiparty sessions, and the evolution of web systems. Finally, we present...... a performance evaluation that includes a comparison of Jolie-based web systems to other frameworks and a measurement of its scalability. © 2016 Elsevier B.V....

  6. Delivering Electronic Resources with Web OPACs and Other Web-based Tools: Needs of Reference Librarians.

    Science.gov (United States)

    Bordeianu, Sever; Carter, Christina E.; Dennis, Nancy K.

    2000-01-01

    Describes Web-based online public access catalogs (Web OPACs) and other Web-based tools as gateway methods for providing access to library collections. Addresses solutions for overcoming barriers to information, such as through the implementation of proxy servers and other authentication tools for remote users. (Contains 18 references.)…

  7. WebViz:A Web-based Collaborative Interactive Visualization System for large-Scale Data Sets

    Science.gov (United States)

    Yuen, D. A.; McArthur, E.; Weiss, R. M.; Zhou, J.; Yao, B.

    2010-12-01

    WebViz is a web-based application designed to conduct collaborative, interactive visualizations of large data sets for multiple users, allowing researchers situated all over the world to utilize the visualization services offered by the University of Minnesota’s Laboratory for Computational Sciences and Engineering (LCSE). This ongoing project has been built upon over the last 3 1/2 years .The motivation behind WebViz lies primarily with the need to parse through an increasing amount of data produced by the scientific community as a result of larger and faster multicore and massively parallel computers coming to the market, including the use of general purpose GPU computing. WebViz allows these large data sets to be visualized online by anyone with an account. The application allows users to save time and resources by visualizing data ‘on the fly’, wherever he or she may be located. By leveraging AJAX via the Google Web Toolkit (http://code.google.com/webtoolkit/), we are able to provide users with a remote, web portal to LCSE's (http://www.lcse.umn.edu) large-scale interactive visualization system already in place at the University of Minnesota. LCSE’s custom hierarchical volume rendering software provides high resolution visualizations on the order of 15 million pixels and has been employed for visualizing data primarily from simulations in astrophysics to geophysical fluid dynamics . In the current version of WebViz, we have implemented a highly extensible back-end framework built around HTTP "server push" technology. The web application is accessible via a variety of devices including netbooks, iPhones, and other web and javascript-enabled cell phones. Features in the current version include the ability for users to (1) securely login (2) launch multiple visualizations (3) conduct collaborative visualization sessions (4) delegate control aspects of a visualization to others and (5) engage in collaborative chats with other users within the user interface

  8. Emergent web intelligence advanced information retrieval

    CERN Document Server

    Badr, Youakim; Abraham, Ajith; Hassanien, Aboul-Ella

    2010-01-01

    Web Intelligence explores the impact of artificial intelligence and advanced information technologies representing the next generation of Web-based systems, services, and environments, and designing hybrid web systems that serve wired and wireless users more efficiently. Multimedia and XML-based data are produced regularly and in increasing way in our daily digital activities, and their retrieval must be explored and studied in this emergent web-based era. 'Emergent Web Intelligence: Advanced information retrieval, provides reviews of the related cutting-edge technologies and insights. It is v

  9. Readability of the web: a study on 1 billion web pages

    NARCIS (Netherlands)

    de Heus, Marije; Hiemstra, Djoerd

    We have performed a readability study on more than 1 billion web pages. The Automated Readability Index was used to determine the average grade level required to easily comprehend a website. Some of the results are that a 16-year-old can easily understand 50% of the web and an 18-year old can easily

  10. web cellHTS2: A web-application for the analysis of high-throughput screening data

    Directory of Open Access Journals (Sweden)

    Boutros Michael

    2010-04-01

    Full Text Available Abstract Background The analysis of high-throughput screening data sets is an expanding field in bioinformatics. High-throughput screens by RNAi generate large primary data sets which need to be analyzed and annotated to identify relevant phenotypic hits. Large-scale RNAi screens are frequently used to identify novel factors that influence a broad range of cellular processes, including signaling pathway activity, cell proliferation, and host cell infection. Here, we present a web-based application utility for the end-to-end analysis of large cell-based screening experiments by cellHTS2. Results The software guides the user through the configuration steps that are required for the analysis of single or multi-channel experiments. The web-application provides options for various standardization and normalization methods, annotation of data sets and a comprehensive HTML report of the screening data analysis, including a ranked hit list. Sessions can be saved and restored for later re-analysis. The web frontend for the cellHTS2 R/Bioconductor package interacts with it through an R-server implementation that enables highly parallel analysis of screening data sets. web cellHTS2 further provides a file import and configuration module for common file formats. Conclusions The implemented web-application facilitates the analysis of high-throughput data sets and provides a user-friendly interface. web cellHTS2 is accessible online at http://web-cellHTS2.dkfz.de. A standalone version as a virtual appliance and source code for platforms supporting Java 1.5.0 can be downloaded from the web cellHTS2 page. web cellHTS2 is freely distributed under GPL.

  11. The Semantic Web in Education

    Science.gov (United States)

    Ohler, Jason

    2008-01-01

    The semantic web or Web 3.0 makes information more meaningful to people by making it more understandable to machines. In this article, the author examines the implications of Web 3.0 for education. The author considers three areas of impact: knowledge construction, personal learning network maintenance, and personal educational administration.…

  12. XML and Better Web Searching.

    Science.gov (United States)

    Jackson, Joe; Gilstrap, Donald L.

    1999-01-01

    Addresses the implications of the new Web metalanguage XML for searching on the World Wide Web and considers the future of XML on the Web. Compared to HTML, XML is more concerned with structure of data than documents, and these data structures should prove conducive to precise, context rich searching. (Author/LRW)

  13. KeyPathwayMinerWeb

    DEFF Research Database (Denmark)

    List, Markus; Alcaraz, Nicolas; Dissing-Hansen, Martin

    2016-01-01

    , for instance), KeyPathwayMiner extracts connected sub-networks containing a high number of active or differentially regulated genes (proteins, metabolites) in the molecular profiles. The web interface at (http://keypathwayminer.compbio.sdu.dk) implements all core functionalities of the KeyPathwayMiner tool set......We present KeyPathwayMinerWeb, the first online platform for de novo pathway enrichment analysis directly in the browser. Given a biological interaction network (e.g. protein-protein interactions) and a series of molecular profiles derived from one or multiple OMICS studies (gene expression...... such as data integration, input of background knowledge, batch runs for parameter optimization and visualization of extracted pathways. In addition to an intuitive web interface, we also implemented a RESTful API that now enables other online developers to integrate network enrichment as a web service...

  14. CAMINO HACIA LA WEB SEMÁNTICA

    Directory of Open Access Journals (Sweden)

    Jorge Alejandro Castillo Morales

    2006-01-01

    Full Text Available El rápido crecimiento de la Word Wide Web ocasiona que sea cada vez más difícil buscar, extraer, interpretar y procesar información de la Web. Como una alternativa a este problema se está desarrollando la Web Semántica - una nueva tecnología que hace que el contenido de la Web sea más significativo a las aplicaciones de software. En la Web Semántica se aumentan anotaciones que expresan el significado de los datos en las páginas Web. Para que estas anotaciones sean útiles, es necesario un entendimiento compartido (entre sus creadores y los usuarios de anotaciones precisamente definidas. Con este propósito se utilizan ontologías – definición de conceptos importantes en un dominio de conocimiento y de las propiedades de cada concepto. Las ontologías permiten definir terminologías y expresar propiedades semánticas. Como resultado, la Web Semántica promete proveer un nivel de automatización e integración que es imposible para la Web actual. Asimismo, la Web Semántica va a poder ejecutar consultas avanzadas que requieren conocimiento de soporte para su resolución.

  15. Public health and Web 2.0.

    Science.gov (United States)

    Hardey, Michael

    2008-07-01

    This article examines the nature and role of Web 2.0 resources and their impact on health information made available though the Internet. The transition of the Web from version one to Web 2.0 is described and the main features of the new Web examined. Two characteristic Web 2.0 resources are explored and the implications for the public and practitioners examined. First, what are known as 'user reviews' or 'user testimonials', which allow people to comment on the health services delivered to them, are described. Second, new mapping applications that take advantage of the interactive potential of Web 2.0 and provide tools to visualize complex data are examined. Following a discussion of the potential of Web 2.0, it is concluded that it offers considerable opportunities for disseminating health information and creating new sources of data, as well as generating new questions and dilemmas.

  16. Engineering semantic web information systems in Hera

    NARCIS (Netherlands)

    Vdovják, R.; Frasincar, F.; Houben, G.J.P.M.; Barna, P.

    2003-01-01

    The success of the World Wide Web has caused the concept of information system to change. Web Information Systems (WIS) use from the Web its paradigm and technologies in order to retrieve information from sources on the Web, and to present the information in terms of a Web or hypermedia

  17. Adaptive web data extraction policies

    Directory of Open Access Journals (Sweden)

    Provetti, Alessandro

    2008-12-01

    Full Text Available Web data extraction is concerned, among other things, with routine data accessing and downloading from continuously-updated dynamic Web pages. There is a relevant trade-off between the rate at which the external Web sites are accessed and the computational burden on the accessing client. We address the problem by proposing a predictive model, typical of the Operating Systems literature, of the rate-of-update of each Web source. The presented model has been implemented into a new version of the Dynamo project: a middleware that assists in generating informative RSS feeds out of traditional HTML Web sites. To be effective, i.e., make RSS feeds be timely and informative and to be scalable, Dynamo needs a careful tuning and customization of its polling policies, which are described in detail.

  18. The EMBRACE web service collection

    DEFF Research Database (Denmark)

    Pettifer, S.; Ison, J.; Kalas, M.

    2010-01-01

    The EMBRACE (European Model for Bioinformatics Research and Community Education) web service collection is the culmination of a 5-year project that set out to investigate issues involved in developing and deploying web services for use in the life sciences. The project concluded that in order...... for web services to achieve widespread adoption, standards must be defined for the choice of web service technology, for semantically annotating both service function and the data exchanged, and a mechanism for discovering services must be provided. Building on this, the project developed: EDAM......, an ontology for describing life science web services; BioXSD, a schema for exchanging data between services; and a centralized registry (http://www.embraceregistry.net) that collects together around 1000 services developed by the consortium partners. This article presents the current status of the collection...

  19. Comparison: Mediation Solutions of WSMOLX and WebML/WebRatio

    Science.gov (United States)

    Zaremba, Maciej; Zaharia, Raluca; Turati, Andrea; Brambilla, Marco; Vitvar, Tomas; Ceri, Stefano

    In this chapter we compare the WSMO/WSML/WSMX andWebML/WebRatio approaches to the SWS-Challenge workshop mediation scenario in terms of the utilized underlying technologies and delivered solutions. In the mediation scenario one partner uses Roset-taNet to define its B2B protocol while the other one operates on a proprietary solution. Both teams shown how these partners could be semantically integrated.

  20. Technical Note: On The Usage and Development of the AWAKE Web Server and Web Applications

    CERN Document Server

    Berger, Dillon Tanner

    2017-01-01

    The purpose of this technical note is to give a brief explanation of the AWAKE Web Server, the current web applications it serves, and how to edit, maintain, and update the source code. The majority of this paper is dedicated to the development of the server and its web applications.

  1. Information Diversity in Web Search

    Science.gov (United States)

    Liu, Jiahui

    2009-01-01

    The web is a rich and diverse information source with incredible amounts of information about all kinds of subjects in various forms. This information source affords great opportunity to build systems that support users in their work and everyday lives. To help users explore information on the web, web search systems should find information that…

  2. Web Service Architecture for e-Learning

    Directory of Open Access Journals (Sweden)

    Xiaohong Qiu

    2005-10-01

    Full Text Available Message-based Web Service architecture provides a unified approach to applications and Web Services that incorporates the flexibility of messaging and distributed components. We propose SMMV and MMMV collaboration as the general architecture of collaboration based on a Web service model, which accommodates both instructor-led learning and participatory learning. This approach derives from our message-based Model-View-Controller (M-MVC architecture of Web applications, comprises an event-driven Publish/Subscribe scheme, and provides effective collaboration with high interactivity of rich Web content for diverse clients over heterogeneous network environments.

  3. Wordpress web application development

    CERN Document Server

    Ratnayake, Rakhitha Nimesh

    2015-01-01

    This book is intended for WordPress developers and designers who want to develop quality web applications within a limited time frame and for maximum profit. Prior knowledge of basic web development and design is assumed.

  4. Using EMBL-EBI Services via Web Interface and Programmatically via Web Services.

    Science.gov (United States)

    Lopez, Rodrigo; Cowley, Andrew; Li, Weizhong; McWilliam, Hamish

    2014-12-12

    The European Bioinformatics Institute (EMBL-EBI) provides access to a wide range of databases and analysis tools that are of key importance in bioinformatics. As well as providing Web interfaces to these resources, Web Services are available using SOAP and REST protocols that enable programmatic access to our resources and allow their integration into other applications and analytical workflows. This unit describes the various options available to a typical researcher or bioinformatician who wishes to use our resources via Web interface or programmatically via a range of programming languages. Copyright © 2014 John Wiley & Sons, Inc.

  5. Benchmarking semantic web technology

    CERN Document Server

    García-Castro, R

    2009-01-01

    This book addresses the problem of benchmarking Semantic Web Technologies; first, from a methodological point of view, proposing a general methodology to follow in benchmarking activities over Semantic Web Technologies and, second, from a practical point of view, presenting two international benchmarking activities that involved benchmarking the interoperability of Semantic Web technologies using RDF(S) as the interchange language in one activity and OWL in the other.The book presents in detail how the different resources needed for these interoperability benchmarking activities were defined:

  6. Express web application development

    CERN Document Server

    Yaapa, Hage

    2013-01-01

    Express Web Application Development is a practical introduction to learning about Express. Each chapter introduces you to a different area of Express, using screenshots and examples to get you up and running as quickly as possible.If you are looking to use Express to build your next web application, ""Express Web Application Development"" will help you get started and take you right through to Express' advanced features. You will need to have an intermediate knowledge of JavaScript to get the most out of this book.

  7. Web Services Integration on the Fly

    National Research Council Canada - National Science Library

    Leong, Hoe W

    2008-01-01

    .... Given data, software agents and supporting software infrastructure, web services integration on the fly means that human coding is not required to integrate web services into a Web Service Architecture...

  8. Node web development

    CERN Document Server

    Herron, David

    2013-01-01

    Presented in a simple, step-by-step format, this book is an introduction to web development with Node.This book is for anybody looking for an alternative to the ""P"" languages (Perl, PHP, Python), or anyone looking for a new paradigm of server-side application development.The reader should have at least a rudimentary understanding of JavaScript and web application development.

  9. Unit 148 - World Wide Web Basics

    OpenAIRE

    148, CC in GIScience; Yeung, Albert K.

    2000-01-01

    This unit explains the characteristics and the working principles of the World Wide Web as the most important protocol of the Internet. Topics covered in this unit include characteristics of the World Wide Web; using the World Wide Web for the dissemination of information on the Internet; and using the World Wide Web for the retrieval of information from the Internet.

  10. Pharyngo-oesophageal webs in dysphageal patients

    International Nuclear Information System (INIS)

    Ekberg, O.; Malmquist, J.; Lindgren, S.

    1986-01-01

    Among 1134 patients, cineradiologically examined because of dysphagia, 85 (7.5%) had webs in the pharyngo-oesophageal segment. Webs were more common in women (10%) compared to men (5%). Radiologic characteristics of the webs such as precise location, multiplicity, circumferential extension, thickness, accompanying streamline phenomenon and encroachment on the lumen, were compared to the presence of concomitant anaemia, thyroid disease, neoplasm, as well as the age and sex of the patients. Webs were regularly deeper in women compared to men. Patients with iron deficiency anaemia had thicker webs compared to patients without such anaemia. No other radiologic characteristics were found that could be used for distinguished these potentially more significant webs from those in patients without such concomitant diseases. (orig.)

  11. Recommender Systems for the Social Web

    CERN Document Server

    Pazos Arias, José J; Díaz Redondo, Rebeca P

    2012-01-01

    The recommendation of products, content and services cannot be considered newly born, although its widespread application is still in full swing. While its growing success in numerous sectors, the progress of the  Social Web has revolutionized the architecture of participation and relationship in the Web, making it necessary to restate recommendation and reconciling it with Collaborative Tagging, as the popularization of authoring in the Web, and  Social Networking, as the translation of personal relationships to the Web. Precisely, the convergence of recommendation with the above Social Web pillars is what motivates this book, which has collected contributions from well-known experts in the academy and the industry to provide a broader view of the problems that Social Recommenders might face with.  If recommender systems have proven their key role in facilitating the user access to resources on the Web, when sharing resources has become social, it is natural for recommendation strategies in the Social Web...

  12. WAPTT - Web Application Penetration Testing Tool

    Directory of Open Access Journals (Sweden)

    DURIC, Z.

    2014-02-01

    Full Text Available Web applications vulnerabilities allow attackers to perform malicious actions that range from gaining unauthorized account access to obtaining sensitive data. The number of reported web application vulnerabilities in last decade is increasing dramatically. The most of vulnerabilities result from improper input validation and sanitization. The most important of these vulnerabilities based on improper input validation and sanitization are: SQL injection (SQLI, Cross-Site Scripting (XSS and Buffer Overflow (BOF. In order to address these vulnerabilities we designed and developed the WAPTT (Web Application Penetration Testing Tool tool - web application penetration testing tool. Unlike other web application penetration testing tools, this tool is modular, and can be easily extended by end-user. In order to improve efficiency of SQLI vulnerability detection, WAPTT uses an efficient algorithm for page similarity detection. The proposed tool showed promising results as compared to six well-known web application scanners in detecting various web application vulnerabilities.

  13. A Typology for Web 2.0

    DEFF Research Database (Denmark)

    Dalsgaard, Christian; Sorensen, Elsebeth Korsgaard

    2008-01-01

    Web 2.0 is a term used to describe recent developments on the World Wide Web. The term is often used to describe the increased use of the web for user-generated content, collaboration, and social networking. However, Web 2.0 is a weakly defined concept, and it is unclear exactly what kind...... of technologies it covers. The objective of the paper is to develop a typology that can be used to categorize Web 2.0 technologies. Further, the paper will discuss which of these technologies are unique to Web 2.0. Often, Web 2.0 is described by way of different kinds of software; for instance, blogs, wikis......, podcasts, RSS, and social networking sites. The problem with this type of description is that it fails to distinguish between different types or categories of technologies. As an alternative, the typology developed in the paper distinguishes between technologies on basis of, how - and in which contexts...

  14. CMS offline web tools

    International Nuclear Information System (INIS)

    Metson, S; Newbold, D; Belforte, S; Kavka, C; Bockelman, B; Dziedziniewicz, K; Egeland, R; Elmer, P; Eulisse, G; Tuura, L; Evans, D; Fanfani, A; Feichtinger, D; Kuznetsov, V; Lingen, F van; Wakefield, S

    2008-01-01

    We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments. The CMS collaboration comprises of nearly 3000 people from all over the world. As well as its collaborators, its computing resources are spread all over globe and are accessed via the LHC grid to run analysis, large scale production and data transfer tasks. Due to the distributed nature of collaborators effective provision of collaborative tools is essential to maximise physics exploitation of the CMS experiment, especially when the size of the CMS data set is considered. CMS has chosen to provide such tools over the world wide web as a top level service, enabling all members of the collaboration to interact with the various offline computing components. Traditionally web interfaces have been added in HEP experiments as an afterthought. In the CMS offline we have decided to put web interfaces, and the development of a common CMS web framework, on an equal footing with the rest of the offline development. Tools exist within CMS to transfer and catalogue data (PhEDEx and DBS/DLS), run Monte Carlo production (ProdAgent) and submit analysis (CRAB). Effective human interfaces to these systems are required for users with different agendas and practical knowledge of the systems to effectively use the CMS computing system. The CMS web tools project aims to provide a consistent interface to all these tools

  15. CMS offline web tools

    Energy Technology Data Exchange (ETDEWEB)

    Metson, S; Newbold, D [H.H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL (United Kingdom); Belforte, S; Kavka, C [INFN, Sezione di Trieste (Italy); Bockelman, B [University of Nebraska Lincoln, Lincoln, NE (United States); Dziedziniewicz, K [CERN, Geneva (Switzerland); Egeland, R [University of Minnesota Twin Cities, Minneapolis, MN (United States); Elmer, P [Princeton (United States); Eulisse, G; Tuura, L [Northeastern University, Boston, MA (United States); Evans, D [Fermilab MS234, Batavia, IL (United States); Fanfani, A [Universita degli Studi di Bologna (Italy); Feichtinger, D [PSI, Villigen (Switzerland); Kuznetsov, V [Cornell University, Ithaca, NY (United States); Lingen, F van [California Institute of Technology, Pasedena, CA (United States); Wakefield, S [Blackett Laboratory, Imperial College, London (United Kingdom)

    2008-07-15

    We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments. The CMS collaboration comprises of nearly 3000 people from all over the world. As well as its collaborators, its computing resources are spread all over globe and are accessed via the LHC grid to run analysis, large scale production and data transfer tasks. Due to the distributed nature of collaborators effective provision of collaborative tools is essential to maximise physics exploitation of the CMS experiment, especially when the size of the CMS data set is considered. CMS has chosen to provide such tools over the world wide web as a top level service, enabling all members of the collaboration to interact with the various offline computing components. Traditionally web interfaces have been added in HEP experiments as an afterthought. In the CMS offline we have decided to put web interfaces, and the development of a common CMS web framework, on an equal footing with the rest of the offline development. Tools exist within CMS to transfer and catalogue data (PhEDEx and DBS/DLS), run Monte Carlo production (ProdAgent) and submit analysis (CRAB). Effective human interfaces to these systems are required for users with different agendas and practical knowledge of the systems to effectively use the CMS computing system. The CMS web tools project aims to provide a consistent interface to all these tools.

  16. Tracing the cosmic web

    Science.gov (United States)

    Libeskind, Noam I.; van de Weygaert, Rien; Cautun, Marius; Falck, Bridget; Tempel, Elmo; Abel, Tom; Alpaslan, Mehmet; Aragón-Calvo, Miguel A.; Forero-Romero, Jaime E.; Gonzalez, Roberto; Gottlöber, Stefan; Hahn, Oliver; Hellwing, Wojciech A.; Hoffman, Yehuda; Jones, Bernard J. T.; Kitaura, Francisco; Knebe, Alexander; Manti, Serena; Neyrinck, Mark; Nuza, Sebastián E.; Padilla, Nelson; Platen, Erwin; Ramachandra, Nesar; Robotham, Aaron; Saar, Enn; Shandarin, Sergei; Steinmetz, Matthias; Stoica, Radu S.; Sousbie, Thierry; Yepes, Gustavo

    2018-01-01

    The cosmic web is one of the most striking features of the distribution of galaxies and dark matter on the largest scales in the Universe. It is composed of dense regions packed full of galaxies, long filamentary bridges, flattened sheets and vast low-density voids. The study of the cosmic web has focused primarily on the identification of such features, and on understanding the environmental effects on galaxy formation and halo assembly. As such, a variety of different methods have been devised to classify the cosmic web - depending on the data at hand, be it numerical simulations, large sky surveys or other. In this paper, we bring 12 of these methods together and apply them to the same data set in order to understand how they compare. In general, these cosmic-web classifiers have been designed with different cosmological goals in mind, and to study different questions. Therefore, one would not a priori expect agreement between different techniques; however, many of these methods do converge on the identification of specific features. In this paper, we study the agreements and disparities of the different methods. For example, each method finds that knots inhabit higher density regions than filaments, etc. and that voids have the lowest densities. For a given web environment, we find a substantial overlap in the density range assigned by each web classification scheme. We also compare classifications on a halo-by-halo basis; for example, we find that 9 of 12 methods classify around a third of group-mass haloes (i.e. Mhalo ∼ 1013.5 h-1 M⊙) as being in filaments. Lastly, so that any future cosmic-web classification scheme can be compared to the 12 methods used here, we have made all the data used in this paper public.

  17. Promoting Your Web Site.

    Science.gov (United States)

    Raeder, Aggi

    1997-01-01

    Discussion of ways to promote sites on the World Wide Web focuses on how search engines work and how they retrieve and identify sites. Appropriate Web links for submitting new sites and for Internet marketing are included. (LRW)

  18. Web Extensible Display Manager

    Energy Technology Data Exchange (ETDEWEB)

    Slominski, Ryan [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Larrieu, Theodore L. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2018-02-01

    Jefferson Lab's Web Extensible Display Manager (WEDM) allows staff to access EDM control system screens from a web browser in remote offices and from mobile devices. Native browser technologies are leveraged to avoid installing and managing software on remote clients such as browser plugins, tunnel applications, or an EDM environment. Since standard network ports are used firewall exceptions are minimized. To avoid security concerns from remote users modifying a control system, WEDM exposes read-only access and basic web authentication can be used to further restrict access. Updates of monitored EPICS channels are delivered via a Web Socket using a web gateway. The software translates EDM description files (denoted with the edl suffix) to HTML with Scalable Vector Graphics (SVG) following the EDM's edl file vector drawing rules to create faithful screen renderings. The WEDM server parses edl files and creates the HTML equivalent in real-time allowing existing screens to work without modification. Alternatively, the familiar drag and drop EDM screen creation tool can be used to create optimized screens sized specifically for smart phones and then rendered by WEDM.

  19. Process-oriented semantic web search

    CERN Document Server

    Tran, DT

    2011-01-01

    The book is composed of two main parts. The first part is a general study of Semantic Web Search. The second part specifically focuses on the use of semantics throughout the search process, compiling a big picture of Process-oriented Semantic Web Search from different pieces of work that target specific aspects of the process.In particular, this book provides a rigorous account of the concepts and technologies proposed for searching resources and semantic data on the Semantic Web. To collate the various approaches and to better understand what the notion of Semantic Web Search entails, this bo

  20. Bringing the Web to America

    CERN Multimedia

    Kunz, P F

    1999-01-01

    On 12 December 1991, Dr. Kunz installed the first Web server outside of Europe at the Stanford Linear Accelerator Center. Today, if you do not have access to the Web you are considered disadvantaged. Before it made sense for Tim Berners-Lee to invent the Web at CERN, there had to a number of ingredients in place. Dr. Kunz will present a history of how these ingredients developed and the role the academic research community had in forming them. In particular, the role that big science, such as high energy physics, played in giving us the Web we have today...

  1. ASH External Web Portal (External Portal) -

    Data.gov (United States)

    Department of Transportation — The ASH External Web Portal is a web-based portal that provides single sign-on functionality, making the web portal a single location from which to be authenticated...

  2. Space Physics Data Facility Web Services

    Science.gov (United States)

    Candey, Robert M.; Harris, Bernard T.; Chimiak, Reine A.

    2005-01-01

    The Space Physics Data Facility (SPDF) Web services provides a distributed programming interface to a portion of the SPDF software. (A general description of Web services is available at http://www.w3.org/ and in many current software-engineering texts and articles focused on distributed programming.) The SPDF Web services distributed programming interface enables additional collaboration and integration of the SPDF software system with other software systems, in furtherance of the SPDF mission to lead collaborative efforts in the collection and utilization of space physics data and mathematical models. This programming interface conforms to all applicable Web services specifications of the World Wide Web Consortium. The interface is specified by a Web Services Description Language (WSDL) file. The SPDF Web services software consists of the following components: 1) A server program for implementation of the Web services; and 2) A software developer s kit that consists of a WSDL file, a less formal description of the interface, a Java class library (which further eases development of Java-based client software), and Java source code for an example client program that illustrates the use of the interface.

  3. Development, implementation and pilot evaluation of a Web-based Virtual Patient Case Simulation environment--Web-SP.

    Science.gov (United States)

    Zary, Nabil; Johnson, Gunilla; Boberg, Jonas; Fors, Uno G H

    2006-02-21

    The Web-based Simulation of Patients (Web-SP) project was initiated in order to facilitate the use of realistic and interactive virtual patients (VP) in medicine and healthcare education. Web-SP focuses on moving beyond the technology savvy teachers, when integrating simulation-based education into health sciences curricula, by making the creation and use of virtual patients easier. The project strives to provide a common generic platform for design/creation, management, evaluation and sharing of web-based virtual patients. The aim of this study was to evaluate if it was possible to develop a web-based virtual patient case simulation environment where the entire case authoring process might be handled by teachers and which would be flexible enough to be used in different healthcare disciplines. The Web-SP system was constructed to support easy authoring, management and presentation of virtual patient cases. The case authoring environment was found to facilitate for teachers to create full-fledged patient cases without the assistance of computer specialists. Web-SP was successfully implemented at several universities by taking into account key factors such as cost, access, security, scalability and flexibility. Pilot evaluations in medical, dentistry and pharmacy courses shows that students regarded Web-SP as easy to use, engaging and to be of educational value. Cases adapted for all three disciplines were judged to be of significant educational value by the course leaders. The Web-SP system seems to fulfil the aim of providing a common generic platform for creation, management and evaluation of web-based virtual patient cases. The responses regarding the authoring environment indicated that the system might be user-friendly enough to appeal to a majority of the academic staff. In terms of implementation strengths, Web-SP seems to fulfil most needs from course directors and teachers from various educational institutions and disciplines. The system is currently in

  4. Prediction value of anti-Mullerian hormone (AMH) serum levels and antral follicle count (AFC) in hormonal contraceptive (HC) users and non-HC users undergoing IVF-PGD treatment.

    Science.gov (United States)

    Bas-Lando, Maayan; Rabinowitz, Ron; Farkash, Rivka; Algur, Nurit; Rubinstein, Esther; Schonberger, Oshrat; Eldar-Geva, Talia

    2017-10-01

    Use of hormone contraceptives (HC) is very popular in the reproductive age and, therefore, evaluation of ovarian reserve would be a useful tool to accurately evaluate the reproductive potential in HC users. We conducted a retrospective cohort study of 41 HC users compared to 57 non-HC users undergoing IVF-preimplantation genetic diagnosis (PGD) aiming to evaluate the effect of HC on the levels of anti-Mullerian hormone (AMH), small (2-5 mm), large (6-10 mm) and total antral follicle count (AFC) and the ability of these markers to predict IVF outcome. Significant differences in large AFC (p = 0.04) and ovarian volume (p users (p users these correlations were weaker. In HC users, the significant predictors of achieving 18 oocytes were AFC (ROC-AUC; 0.958, p = 0.001 and 0.883, p = 0.001) and AMH (ROC-AUC-0.858, p = 0.01 and 0.878, p = 0.001), respectively. The predictive values were less significant in non-HC users. These findings are important in women treated for PGD, in ovum donors and for assessing the fertility prognosis in women using HC and wishing to postpone pregnancy.

  5. WebGeoOlap: Multidimensional geographic data visualization for web environments

    Directory of Open Access Journals (Sweden)

    SILVA, R. O. L.

    2008-06-01

    Full Text Available As the web is continuously maturing platform, a growing number of technology is leading Geographic Information Systems (GIS and Analytical (OLAP closer to being developed for the web environment. The great challenge of this work is to integrate these technologies, OLAP and GIS, in a single application, using Ajax, so that the user can perform the analysis of analytical data and view data geographic in the map, using Google Maps.

  6. Instant Flask web development

    CERN Document Server

    DuPlain, Ron

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. The book uses a bottom-up approach to help you build applications, and is full of step-by-step instructions and practical examples to help you improve your knowledge.Instant Flask Web Development is for developers who are new to web programming, or are familiar with web programming but new to Flask. This book gives you a head start if you have some beginner experience with Python and HTML, or are willing to learn.

  7. Portal Web 2.0

    OpenAIRE

    Barba Hidalgo, José Manuel

    2008-01-01

    El tema que es tracta en aquest projecte gira al voltant del concepte Web 2.0. Després d’una introducció on es comenten les principals característiques que defineixen el conjunt d’aplicacions agrupades al voltant d’aquesta filosofia, s’analitzen diferents entorns de desenvolupament d’aplicacions Web, amb l’objectiu de crear un portal que segueixi els principis Web 2.0. El resultat de l’estudi presenta a Ruby on Rails com un ferm candidat, això fa que es procedeixi a estudiar aq...

  8. Programming NET Web Services

    CERN Document Server

    Ferrara, Alex

    2007-01-01

    Web services are poised to become a key technology for a wide range of Internet-enabled applications, spanning everything from straight B2B systems to mobile devices and proprietary in-house software. While there are several tools and platforms that can be used for building web services, developers are finding a powerful tool in Microsoft's .NET Framework and Visual Studio .NET. Designed from scratch to support the development of web services, the .NET Framework simplifies the process--programmers find that tasks that took an hour using the SOAP Toolkit take just minutes. Programming .NET

  9. Applied Semantic Web Technologies

    CERN Document Server

    Sugumaran, Vijayan

    2011-01-01

    The rapid advancement of semantic web technologies, along with the fact that they are at various levels of maturity, has left many practitioners confused about the current state of these technologies. Focusing on the most mature technologies, Applied Semantic Web Technologies integrates theory with case studies to illustrate the history, current state, and future direction of the semantic web. It maintains an emphasis on real-world applications and examines the technical and practical issues related to the use of semantic technologies in intelligent information management. The book starts with

  10. The RNAsnp web server

    DEFF Research Database (Denmark)

    Radhakrishnan, Sabarinathan; Tafer, Hakim; Seemann, Ernst Stefan

    2013-01-01

    , are derived from extensive pre-computed tables of distributions of substitution effects as a function of gene length and GC content. Here, we present a web service that not only provides an interface for RNAsnp but also features a graphical output representation. In addition, the web server is connected...... to a local mirror of the UCSC genome browser database that enables the users to select the genomic sequences for analysis and visualize the results directly in the UCSC genome browser. The RNAsnp web server is freely available at: http://rth.dk/resources/rnasnp/....

  11. Silicon web process development

    Science.gov (United States)

    Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Skutch, M. E.; Driggers, J. M.; Hopkins, R. H.

    1981-01-01

    The silicon web process takes advantage of natural crystallographic stabilizing forces to grow long, thin single crystal ribbons directly from liquid silicon. The ribbon, or web, is formed by the solidification of a liquid film supported by surface tension between two silicon filaments, called dendrites, which border the edges of the growing strip. The ribbon can be propagated indefinitely by replenishing the liquid silicon as it is transformed to crystal. The dendritic web process has several advantages for achieving low cost, high efficiency solar cells. These advantages are discussed.

  12. Building Web Reputation Systems

    CERN Document Server

    Farmer, Randy

    2010-01-01

    What do Amazon's product reviews, eBay's feedback score system, Slashdot's Karma System, and Xbox Live's Achievements have in common? They're all examples of successful reputation systems that enable consumer websites to manage and present user contributions most effectively. This book shows you how to design and develop reputation systems for your own sites or web applications, written by experts who have designed web communities for Yahoo! and other prominent sites. Building Web Reputation Systems helps you ask the hard questions about these underlying mechanisms, and why they're critical

  13. Development of a laboratory niche Web site.

    Science.gov (United States)

    Dimenstein, Izak B; Dimenstein, Simon I

    2013-10-01

    This technical note presents the development of a methodological laboratory niche Web site. The "Grossing Technology in Surgical Pathology" (www.grossing-technology.com) Web site is used as an example. Although common steps in creation of most Web sites are followed, there are particular requirements for structuring the template's menu on methodological laboratory Web sites. The "nested doll principle," in which one object is placed inside another, most adequately describes the methodological approach to laboratory Web site design. Fragmentation in presenting the Web site's material highlights the discrete parts of the laboratory procedure. An optimally minimal triad of components can be recommended for the creation of a laboratory niche Web site: a main set of media, a blog, and an ancillary component (host, contact, and links). The inclusion of a blog makes the Web site a dynamic forum for professional communication. By forming links and portals, cloud computing opens opportunities for connecting a niche Web site with other Web sites and professional organizations. As an additional source of information exchange, methodological laboratory niche Web sites are destined to parallel both traditional and new forms, such as books, journals, seminars, webinars, and internal educational materials. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles.

    Directory of Open Access Journals (Sweden)

    Nicholas Hatzirodos

    Full Text Available In studies using isolated ovarian granulosa and thecal cells it is important to assess the degree of cross contamination. Marker genes commonly used for granulosa cells include FSHR, CYP19A1 and AMH while CYP17A1 and INSL3 are used for thecal cells. To increase the number of marker genes available we compared expression microarray data from isolated theca interna with that from granulosa cells of bovine small (n = 10 for both theca and granulosa cells; 3-5 mm and large (n = 4 for both theca and granulosa cells, > 9 mm antral follicles. Validation was conducted by qRT-PCR analyses. Known markers such as CYP19A1, FSHR and NR5A2 and another 11 genes (LOC404103, MGARP, GLDC, CHST8, CSN2, GPX3, SLC35G1, CA8, CLGN, FAM78A, SLC16A3 were common to the lists of the 50 most up regulated genes in granulosa cells from both follicle sizes. The expression in theca interna was more consistent than in granulosa cells between the two follicle sizes. Many genes up regulated in theca interna were common to both sizes of follicles (MGP, DCN, ASPN, ALDH1A1, COL1A2, FN1, COL3A1, OGN, APOD, COL5A2, IGF2, NID1, LHFP, ACTA2, DUSP12, ACTG2, SPARCL1, FILIP1L, EGFLAM, ADAMDEC1, HPGD, COL12A1, FBLN5, RAMP2, COL15A1, PLK2, COL6A3, LOXL1, RARRES1, FLI1, LAMA2. Many of these were stromal extracellular matrix genes. MGARP, GLDC, CHST8, GPX3 were identified as new potential markers for granulosa cells, while FBLN5, OGN, RAMP2 were significantly elevated in the theca interna.

  15. The definitive guide to HTML5 WebSocket

    CERN Document Server

    Wang, Vanessa; Moskovits, Peter

    2013-01-01

    The Definitive Guide to HTML5 WebSocket is the ultimate insider's WebSocket resource. This revolutionary new web technology enables you to harness the power of true real-time connectivity and build responsive, modern web applications.   This book contains everything web developers and architects need to know about WebSocket. It discusses how WebSocket-based architectures provide a dramatic reduction in unnecessary network overhead and latency compared to older HTTP (Ajax) architectures, how to layer widely used protocols such as XMPP and STOMP on top of WebSocket, and how to secure WebSocket c

  16. The real business of web design

    CERN Document Server

    Waters, John

    2004-01-01

    Written by a veteran Web designer, The Real Business of Web Design goes beyond the usual philosophy of simply creating a better customer experience online. Instead, it provides an array of visual design practices and tested business principles for clarifying and simplifying the Web development process and making a Website more customer friendly. Filled with anecdotes from the author's own experiences in the web design trenches, this guide shows readers how to use the Web in crucial ways to streamline communications, speed up transactions, boost profits, and much more. Anyone who wants to use t

  17. Creating Web Sites The Missing Manual

    CERN Document Server

    MacDonald, Matthew

    2006-01-01

    Think you have to be a technical wizard to build a great web site? Think again. For anyone who wants to create an engaging web site--for either personal or business purposes--Creating Web Sites: The Missing Manual demystifies the process and provides tools, techniques, and expert guidance for developing a professional and reliable web presence. Like every Missing Manual, you can count on Creating Web Sites: The Missing Manual to be entertaining and insightful and complete with all the vital information, clear-headed advice, and detailed instructions you need to master the task at hand. Autho

  18. Caching web service for TICF project

    International Nuclear Information System (INIS)

    Pais, V.F.; Stancalie, V.

    2008-01-01

    A caching web service was developed to allow caching of any object to a network cache, presented in the form of a web service. This application was used to increase the speed of previously implemented web services and for new ones. Various tests were conducted to determine the impact of using this caching web service in the existing network environment and where it should be placed in order to achieve the greatest increase in performance. Since the cache is presented to applications as a web service, it can also be used for remote access to stored data and data sharing between applications

  19. Office 2010 Web Apps For Dummies

    CERN Document Server

    Weverka, Peter

    2010-01-01

    Enhance your Microsoft Office 2010 experience with Office 2010 Web Apps!. Office Web Apps complement Office, making it easy to access and edit files from anywhere. It also simplifies collaboration with those who don't have Microsoft Office on their computers. This helpful book shows you the optimum ways you can use Office Web Apps to save time and streamline your work. Veteran For Dummies author Peter Weverka begins with an introduction to Office Web Apps and then goes on to clearly explain how Office Web Apps provide you with easier, faster, more flexible ways to get things done.: Walks you t

  20. Building Web Apps for Google TV

    CERN Document Server

    Ferrate, Andres; Lee, Daniels; Ohye, Maile; Carff, Paul; Shen, Shawn; Hines, Steven

    2011-01-01

    By integrating the Web with traditional TV, Google TV offers developers an important new channel for content. But creating apps for Google TV requires learning some new skills-in fact, what you may already know about mobile or desktop web apps isn't entirely applicable. Building Web Apps for Google TV will help you make the transition to Google TV as you learn the tools and techniques necessary to build sophisticated web apps for this platform. This book shows you how Google TV works, how it fits into the web ecosystem, and what the opportunities are for delivering rich content to millions o

  1. EPA Web Training Classes

    Science.gov (United States)

    Scheduled webinars can help you better manage EPA web content. Class topics include Drupal basics, creating different types of pages in the WebCMS such as document pages and forms, using Google Analytics, and best practices for metadata and accessibility.

  2. WebGimm: An integrated web-based platform for cluster analysis, functional analysis, and interactive visualization of results.

    Science.gov (United States)

    Joshi, Vineet K; Freudenberg, Johannes M; Hu, Zhen; Medvedovic, Mario

    2011-01-17

    Cluster analysis methods have been extensively researched, but the adoption of new methods is often hindered by technical barriers in their implementation and use. WebGimm is a free cluster analysis web-service, and an open source general purpose clustering web-server infrastructure designed to facilitate easy deployment of integrated cluster analysis servers based on clustering and functional annotation algorithms implemented in R. Integrated functional analyses and interactive browsing of both, clustering structure and functional annotations provides a complete analytical environment for cluster analysis and interpretation of results. The Java Web Start client-based interface is modeled after the familiar cluster/treeview packages making its use intuitive to a wide array of biomedical researchers. For biomedical researchers, WebGimm provides an avenue to access state of the art clustering procedures. For Bioinformatics methods developers, WebGimm offers a convenient avenue to deploy their newly developed clustering methods. WebGimm server, software and manuals can be freely accessed at http://ClusterAnalysis.org/.

  3. Pedagogy for teaching and learning cooperatively on the Web: a Web-based pharmacology course.

    Science.gov (United States)

    Tse, Mimi M Y; Pun, Sandra P Y; Chan, Moon Fai

    2007-02-01

    The Internet is becoming a preferred place to find information. Millions of people go online in the search of health and medical information. Likewise, the demand for Web-based courses grows. This article presents the development, utilization and evaluation of a web-based pharmacology course for nursing students. The course was developed based on 150 commonly used drugs. There were 110 year 1 nursing students took part in the course. After attending six hours face to face lecture of pharmacology over three weeks, students were invited to complete a questionnaire (pre-test) about learning pharmacology. The course materials were then uploaded to a WebCT for student's self-directed learning and attempts to pass two scheduled online quizzes. At the end of the semester, students were given the same questionnaire (post-test). There were a significant increase in the understanding compared with memorizing the subject content, the development of problem solving ability in learning pharmacology and becoming an independent learner (p ,0.05). Online quizzes yielded satisfactory results. In the focused group interview, students appreciated the time flexibility and convenience associated with web-based learning, also, they had made good suggestions in enhancing web-based learning. Web-based approach is promising for teaching and learning pharmacology for nurses and other health-care professionals.

  4. Materializing the web of linked data

    CERN Document Server

    Konstantinou, Nikolaos

    2015-01-01

    This book explains the Linked Data domain by adopting a bottom-up approach: it introduces the fundamental Semantic Web technologies and building blocks, which are then combined into methodologies and end-to-end examples for publishing datasets as Linked Data, and use cases that harness scholarly information and sensor data. It presents how Linked Data is used for web-scale data integration, information management and search. Special emphasis is given to the publication of Linked Data from relational databases as well as from real-time sensor data streams. The authors also trace the transformation from the document-based World Wide Web into a Web of Data. Materializing the Web of Linked Data is addressed to researchers and professionals studying software technologies, tools and approaches that drive the Linked Data ecosystem, and the Web in general.

  5. EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data.

    Science.gov (United States)

    Koulouras, Grigorios; Panagopoulos, Andreas; Rapsomaniki, Maria A; Giakoumakis, Nickolaos N; Taraviras, Stavros; Lygerou, Zoi

    2018-06-13

    Understanding protein dynamics is crucial in order to elucidate protein function and interactions. Advances in modern microscopy facilitate the exploration of the mobility of fluorescently tagged proteins within living cells. Fluorescence recovery after photobleaching (FRAP) is an increasingly popular functional live-cell imaging technique which enables the study of the dynamic properties of proteins at a single-cell level. As an increasing number of labs generate FRAP datasets, there is a need for fast, interactive and user-friendly applications that analyze the resulting data. Here we present easyFRAP-web, a web application that simplifies the qualitative and quantitative analysis of FRAP datasets. EasyFRAP-web permits quick analysis of FRAP datasets through an intuitive web interface with interconnected analysis steps (experimental data assessment, different types of normalization and estimation of curve-derived quantitative parameters). In addition, easyFRAP-web provides dynamic and interactive data visualization and data and figure export for further analysis after every step. We test easyFRAP-web by analyzing FRAP datasets capturing the mobility of the cell cycle regulator Cdt2 in the presence and absence of DNA damage in cultured cells. We show that easyFRAP-web yields results consistent with previous studies and highlights cell-to-cell heterogeneity in the estimated kinetic parameters. EasyFRAP-web is platform-independent and is freely accessible at: https://easyfrap.vmnet.upatras.gr/.

  6. Theoretical Foundations of the Web: Cognition, Communication, and Co-Operation. Towards an Understanding of Web 1.0, 2.0, 3.0

    Directory of Open Access Journals (Sweden)

    Robert Bichler

    2010-02-01

    Full Text Available Currently, there is much talk of Web 2.0 and Social Software. A common understanding of these notions is not yet in existence. The question of what makes Social Software social has thus far also remained unacknowledged. In this paper we provide a theoretical understanding of these notions by outlining a model of the Web as a techno-social system that enhances human cognition towards communication and co-operation. According to this understanding, we identify three qualities of the Web, namely Web 1.0 as a Web of cognition, Web 2.0 as a Web of human communication, and Web 3.0 as a Web of co-operation. We use the terms Web 1.0, Web 2.0, Web 3.0 not in a technical sense, but for describing and characterizing the social dynamics and information processes that are part of the Internet.

  7. OneWeb: plataforma de adaptación de contenidos web basada en las recomendaciones del W3C Mobile Web Initiative

    Directory of Open Access Journals (Sweden)

    Francisco O. Martínez P.

    2011-01-01

    Full Text Available Las limitaciones con respecto a la experiencia de navegabilidad y facilidad de uso constituyen los principales obstáculos que enfrenta la web móvil para lograr una amplia aceptación mundial. Recientemente el W3C ha desarrollado una iniciativa conocida como Mobile Web Initiative (MWI, la cual define un conjunto de directrices para el diseño y presentación adecuada de interfaces web dirigidas a dispositivos móviles. El presente artículo describe las principales características y los módulos funcionales de OneWeb, una plataforma de adaptación de contenidos basada en las recomendaciones de MWI, desarrollada por el Grupo de Interés en el Desarrollo de Aplicaciones Móviles para Dispositivos Móviles - W@PColombia, adscrito al Grupo de Ingeniería Telemática de la Universidad del Cauca. Adicionalmente se presentan medidas de rendimiento y una comparación con sistemas de adaptación de contenido que operan actualmente. De manera experimental se obtuvieron tiempos de respuesta satisfactorios para entornos web móviles y se logró el cumplimiento de las recomendaciones de MWI sobre un conjunto de veinte páginas de prueba.

  8. Association and Sequence Mining in Web Usage

    Directory of Open Access Journals (Sweden)

    Claudia Elena DINUCA

    2011-06-01

    Full Text Available Web servers worldwide generate a vast amount of information on web users’ browsing activities. Several researchers have studied these so-called clickstream or web access log data to better understand and characterize web users. Clickstream data can be enriched with information about the content of visited pages and the origin (e.g., geographic, organizational of the requests. The goal of this project is to analyse user behaviour by mining enriched web access log data. With the continued growth and proliferation of e-commerce, Web services, and Web-based information systems, the volumes of click stream and user data collected by Web-based organizations in their daily operations has reached astronomical proportions. This information can be exploited in various ways, such as enhancing the effectiveness of websites or developing directed web marketing campaigns. The discovered patterns are usually represented as collections of pages, objects, or re-sources that are frequently accessed by groups of users with common needs or interests. The focus of this paper is to provide an overview how to use frequent pattern techniques for discovering different types of patterns in a Web log database. In this paper we will focus on finding association as a data mining technique to extract potentially useful knowledge from web usage data. I implemented in Java, using NetBeans IDE, a program for identification of pages’ association from sessions. For exemplification, we used the log files from a commercial web site.

  9. Sexual information seeking on web search engines.

    Science.gov (United States)

    Spink, Amanda; Koricich, Andrew; Jansen, B J; Cole, Charles

    2004-02-01

    Sexual information seeking is an important element within human information behavior. Seeking sexually related information on the Internet takes many forms and channels, including chat rooms discussions, accessing Websites or searching Web search engines for sexual materials. The study of sexual Web queries provides insight into sexually-related information-seeking behavior, of value to Web users and providers alike. We qualitatively analyzed queries from logs of 1,025,910 Alta Vista and AlltheWeb.com Web user queries from 2001. We compared the differences in sexually-related Web searching between Alta Vista and AlltheWeb.com users. Differences were found in session duration, query outcomes, and search term choices. Implications of the findings for sexual information seeking are discussed.

  10. Web-enabling technologies for the factory floor: a web-enabling strategy for emanufacturing

    Science.gov (United States)

    Velez, Ricardo; Lastra, Jose L. M.; Tuokko, Reijo O.

    2001-10-01

    This paper is intended to address the different technologies available for Web-enabling of the factory floor. It will give an overview of the importance of Web-enabling of the factory floor, in the application of the concepts of flexible and intelligent manufacturing, in conjunction with e-commerce. As a last section, it will try to define a Web-enabling strategy for the application in eManufacturing. This is made under the scope of the electronics manufacturing industry, so every application, technology or related matter is presented under such scope.

  11. Using Web 2.0 for health promotion and social marketing efforts: lessons learned from Web 2.0 experts.

    Science.gov (United States)

    Dooley, Jennifer Allyson; Jones, Sandra C; Iverson, Don

    2014-01-01

    Web 2.0 experts working in social marketing participated in qualitative in-depth interviews. The research aimed to document the current state of Web 2.0 practice. Perceived strengths (such as the viral nature of Web 2.0) and weaknesses (such as the time consuming effort it took to learn new Web 2.0 platforms) existed when using Web 2.0 platforms for campaigns. Lessons learned were identified--namely, suggestions for engaging in specific types of content creation strategies (such as plain language and transparent communication practices). Findings present originality and value to practitioners working in social marketing who want to effectively use Web 2.0.

  12. WebAL Comes of Age: A review of the first 21 years of Artificial Life on the Web

    DEFF Research Database (Denmark)

    Taylor, Tim; Auerbach, Joshua E; Bongard, Josh

    2016-01-01

    We present a survey of the first 21 years of web-based artificial life (WebAL) research and applications, broadly construed to include the many different ways in which artificial life and web technologies might intersect. Our survey covers the period from 1994—when the first WebAL work appeared...

  13. Deep Web and Dark Web: Deep World of the Internet

    OpenAIRE

    Çelik, Emine

    2018-01-01

    The Internet is undoubtedly still a revolutionary breakthrough in the history of humanity. Many people use the internet for communication, social media, shopping, political and social agenda, and more. Deep Web and Dark Web concepts not only handled by computer, software engineers but also handled by social siciensists because of the role of internet for the States in international arenas, public institutions and human life. By the moving point that very importantrole of internet for social s...

  14. Gender and web design software

    Directory of Open Access Journals (Sweden)

    Gabor Horvath

    2007-12-01

    Full Text Available There are several studies dealing with the differences between sites originated by men and women. However, these references are mainly related to the "output", the final web site. In our research we examined the input side of web designing. We thoroughly analysed a number of randomly selected web designer softwares to see, whether and to what extent the templates they offer determine the final look of an individual's website. We have found that most of them are typical masculine templates, which makes it difficult to any women to design a feminine looking website. It can be one of the reasons of the masculine website hegemony on the web.

  15. Beyond Web 2.0 … and Beyond the Semantic Web

    Science.gov (United States)

    Bénel, Aurélien; Zhou, Chao; Cahier, Jean-Pierre

    Tim O'Reilly, the famous technology book publisher, changed the life of many of us when he coined the name "Web 2.0" (O' Reilly 2005). Our research topics suddenly became subjects for open discussion in various cultural formats such as radio and TV, while at the same time they became part of an inappropriate marketing discourse according to several scientific reviewers. Indeed Tim O'Reilly's initial thoughts were about economic consequence, since it was about the resurrection of the Web after the bursting of the dot-com bubble. Some opponents of the concept do not think the term should be used at all since it is underpinned by no technological revolution. In contrast, we think that there was a paradigm shift when several sites based on user-generated content became some of the most visited Web sites and massive adoption of that kind is worthy of researchers' attention.

  16. Web-Beagle: a web server for the alignment of RNA secondary structures.

    Science.gov (United States)

    Mattei, Eugenio; Pietrosanto, Marco; Ferrè, Fabrizio; Helmer-Citterich, Manuela

    2015-07-01

    Web-Beagle (http://beagle.bio.uniroma2.it) is a web server for the pairwise global or local alignment of RNA secondary structures. The server exploits a new encoding for RNA secondary structure and a substitution matrix of RNA structural elements to perform RNA structural alignments. The web server allows the user to compute up to 10 000 alignments in a single run, taking as input sets of RNA sequences and structures or primary sequences alone. In the latter case, the server computes the secondary structure prediction for the RNAs on-the-fly using RNAfold (free energy minimization). The user can also compare a set of input RNAs to one of five pre-compiled RNA datasets including lncRNAs and 3' UTRs. All types of comparison produce in output the pairwise alignments along with structural similarity and statistical significance measures for each resulting alignment. A graphical color-coded representation of the alignments allows the user to easily identify structural similarities between RNAs. Web-Beagle can be used for finding structurally related regions in two or more RNAs, for the identification of homologous regions or for functional annotation. Benchmark tests show that Web-Beagle has lower computational complexity, running time and better performances than other available methods. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. The DIRAC Web Portal 2.0

    Science.gov (United States)

    Mathe, Z.; Casajus Ramo, A.; Lazovsky, N.; Stagni, F.

    2015-12-01

    For many years the DIRAC interware (Distributed Infrastructure with Remote Agent Control) has had a web interface, allowing the users to monitor DIRAC activities and also interact with the system. Since then many new web technologies have emerged, therefore a redesign and a new implementation of the DIRAC Web portal were necessary, taking into account the lessons learnt using the old portal. These new technologies allowed to build a more compact, robust and responsive web interface that enables users to have better control over the whole system while keeping a simple interface. The web framework provides a large set of “applications”, each of which can be used for interacting with various parts of the system. Communities can also create their own set of personalised web applications, and can easily extend already existing ones with a minimal effort. Each user can configure and personalise the view for each application and save it using the DIRAC User Profile service as RESTful state provider, instead of using cookies. The owner of a view can share it with other users or within a user community. Compatibility between different browsers is assured, as well as with mobile versions. In this paper, we present the new DIRAC Web framework as well as the LHCb extension of the DIRAC Web portal.

  18. Ten years for the public Web

    CERN Multimedia

    2003-01-01

    Ten years ago, CERN issued a statement declaring that a little known piece of software called the World Wide Web was in the public domain. Nowadays, the Web is an indispensable part of modern communications. The idea for the Web goes back to March 1989 when CERN Computer scientist Tim Berners-Lee wrote a proposal for a 'Distributed Information Management System' for the high-energy physics community. The Web was originaly conceived and developed to meet the demand for information sharing between scientists working all over the world. There were many obstacles in the 1980s to the effective exchange of information. There was, for example a great variety of computer and network systems, with hardly any common features. The main purpose of the web was to allow scientists to access information from any source in a consistent and simple way. By Christmas 1990, Berners-Lee's idea had become the World Wide Web, with its first server and browser running at CERN. Through 1991, the Web spread to other particle physics ...

  19. Consistency in the World Wide Web

    DEFF Research Database (Denmark)

    Thomsen, Jakob Grauenkjær

    Tim Berners-Lee envisioned that computers will behave as agents of humans on the World Wide Web, where they will retrieve, extract, and interact with information from the World Wide Web. A step towards this vision is to make computers capable of extracting this information in a reliable...... and consistent way. In this dissertation we study steps towards this vision by showing techniques for the specication, the verication and the evaluation of the consistency of information in the World Wide Web. We show how to detect certain classes of errors in a specication of information, and we show how...... the World Wide Web, in order to help perform consistent evaluations of web extraction techniques. These contributions are steps towards having computers reliable and consistently extract information from the World Wide Web, which in turn are steps towards achieving Tim Berners-Lee's vision. ii...

  20. Pro JavaScript for web apps

    CERN Document Server

    Freeman, Adam

    2012-01-01

    JavaScript is the engine behind every web app, and a solid knowledge of it is essential for all modern web developers. Pro JavaScript for Web Apps gives you all of the information that you need to create professional, optimized, and efficient JavaScript applications that will run across all devices. It takes you through all aspects of modern JavaScript application creation, showing you how to combine JavaScript with the new features of HTML5 and CSS3 to make the most of the new web technologies. The focus of the book is on creating professional web applications, ensuring that your app provides

  1. 8th Chinese Conference on The Semantic Web and Web Science

    CERN Document Server

    Du, Jianfeng; Wang, Haofen; Wang, Peng; Ji, Donghong; Pan, Jeff Z; CSWS 2014

    2014-01-01

    This book constitutes the thoroughly refereed papers of the 8th Chinese Conference on The Semantic Web and Web Science, CSWS 2014, held in Wuhan, China, in August 2014. The 22 research papers presented were carefully reviewed and selected from 61 submissions. The papers are organized in topical sections such as ontology reasoning and learning; semantic data generation and management; and semantic technology and applications.

  2. Web 2.0: A Strategy Guide

    CERN Document Server

    Shuen, Amy

    2008-01-01

    Web 2.0 makes headlines, but how does it make money? This concise guide explains what's different about Web 2.0 and how those differences can improve the bottom line. Whether you're an executive, a small business owner, or an entrepreneur, Web 2.0: A Strategy Guide illustrates through real life examples how various businesses are creating new opportunities on today's Web. This book is about strategy rather than the technology itself.

  3. A reasonable Semantic Web

    NARCIS (Netherlands)

    Hitzler, Pascal; Van Harmelen, Frank

    2010-01-01

    The realization of Semantic Web reasoning is central to substantiating the Semantic Web vision. However, current mainstream research on this topic faces serious challenges, which forces us to question established lines of research and to rethink the underlying approaches. We argue that reasoning for

  4. Head First Web Design

    CERN Document Server

    Watrall, Ethan

    2008-01-01

    Want to know how to make your pages look beautiful, communicate your message effectively, guide visitors through your website with ease, and get everything approved by the accessibility and usability police at the same time? Head First Web Design is your ticket to mastering all of these complex topics, and understanding what's really going on in the world of web design. Whether you're building a personal blog or a corporate website, there's a lot more to web design than div's and CSS selectors, but what do you really need to know? With this book, you'll learn the secrets of designing effecti

  5. Models and methods for building web recommendation systems

    OpenAIRE

    Stekh, Yu.; Artsibasov, V.

    2012-01-01

    Modern Word Wide Web contains a large number of Web sites and pages in each Web site. Web recommendation system (recommendation system for web pages) are typically implemented on web servers and use the data obtained from the collection viewed web templates (implicit data) or user registration data (explicit data). In article considering methods and algorithms of web recommendation system based on the technology of data mining (web mining). Сучасна мережа Інтернет містить велику кількість веб...

  6. A Web Service Framework for Economic Applications

    Directory of Open Access Journals (Sweden)

    Dan BENTA

    2010-01-01

    Full Text Available The Internet offers multiple solutions to linkcompanies with their partners, customers or suppliersusing IT solutions, including a special focus on Webservices. Web services are able to solve the problem relatedto the exchange of data between business partners, marketsthat can use each other's services, problems ofincompatibility between IT applications. As web servicesare described, discovered and accessed programs based onXML vocabularies and Web protocols, Web servicesrepresents solutions for Web-based technologies for smalland medium-sized enterprises (SMEs. This paper presentsa web service framework for economic applications. Also, aprototype of this IT solution using web services waspresented and implemented in a few companies from IT,commerce and consulting fields measuring the impact ofthe solution in the business environment development.

  7. Configuration of Web services as parametric design

    NARCIS (Netherlands)

    Ten Teije, Annette; Van Harmelen, Frank; Wielinga, Bob

    2004-01-01

    The configuration of Web services is particularly hard given the heterogeneous, unreliable and open nature of the Web. Furthermore, such composite Web services are likely to be complex services, that will require adaptation for each specific use. Current approaches to Web service configuration are

  8. Web-based tailored intervention for preparation of parents and children for outpatient surgery (WebTIPS): development.

    Science.gov (United States)

    Kain, Zeev N; Fortier, Michelle A; Chorney, Jill MacLaren; Mayes, Linda

    2015-04-01

    As a result of cost-containment efforts, preparation programs for outpatient surgery are currently not available to the majority of children and parents. The recent dramatic growth in the Internet presents a unique opportunity to transform how children and their parents are prepared for surgery. In this article, we describe the development of a Web-based Tailored Intervention for Preparation of parents and children undergoing Surgery (WebTIPS). A multidisciplinary taskforce agreed that a Web-based tailored intervention consisting of intake, matrix, and output modules was the preferred approach. Next, the content of the various intake variables, the matrix logic, and the output content was developed. The output product has a parent component and a child component and is described in http://surgerywebtips.com/about.php. The child component makes use of preparation strategies such as information provision, modeling, play, and coping skills training. The parent component of WebTIPS includes strategies such as information provision, coping skills training, and relaxation and distraction techniques. A reputable animation and Web design company developed a secured Web-based product based on the above description. In this article, we describe the development of a Web-based tailored preoperative preparation program that can be accessed by children and parents multiple times before and after surgery. A follow-up article in this issue of Anesthesia & Analgesia describes formative evaluation and preliminary efficacy testing of this Web-based tailored preoperative preparation program.

  9. Creating a web site the missing manual

    CERN Document Server

    MacDonald, Matthew

    2008-01-01

    Think you have to be a technical wizard to build a great web site? Think again. If you want to create an engaging web site, this thoroughly revised, completely updated edition of Creating a Web Site: The Missing Manual demystifies the process and provides tools, techniques, and expert guidance for developing a professional and reliable web presence. Whether you want to build a personal web site, an e-commerce site, a blog, or a web site for a specific occasion or promotion, this book gives you detailed instructions and clear-headed advice for: Everything from planning to launching. From pi

  10. Capturing Trust in Social Web Applications

    Science.gov (United States)

    O'Donovan, John

    The Social Web constitutes a shift in information flow from the traditional Web. Previously, content was provided by the owners of a website, for consumption by the end-user. Nowadays, these websites are being replaced by Social Web applications which are frameworks for the publication of user-provided content. Traditionally, Web content could be `trusted' to some extent based on the site it originated from. Algorithms such as Google's PageRank were (and still are) used to compute the importance of a website, based on analysis of underlying link topology. In the Social Web, analysis of link topology merely tells us about the importance of the information framework which hosts the content. Consumers of information still need to know about the importance/reliability of the content they are reading, and therefore about the reliability of the producers of that content. Research into trust and reputation of the producers of information in the Social Web is still very much in its infancy. Every day, people are forced to make trusting decisions about strangers on the Web based on a very limited amount of information. For example, purchasing a product from an eBay seller with a `reputation' of 99%, downloading a file from a peer-to-peer application such as Bit-Torrent, or allowing Amazon.com tell you what products you will like. Even something as simple as reading comments on a Web-blog requires the consumer to make a trusting decision about the quality of that information. In all of these example cases, and indeed throughout the Social Web, there is a pressing demand for increased information upon which we can make trusting decisions. This chapter examines the diversity of sources from which trust information can be harnessed within Social Web applications and discusses a high level classification of those sources. Three different techniques for harnessing and using trust from a range of sources are presented. These techniques are deployed in two sample Social Web

  11. Web-Based Distributed XML Query Processing

    NARCIS (Netherlands)

    Smiljanic, M.; Feng, L.; Jonker, Willem; Blanken, Henk; Grabs, T.; Schek, H-J.; Schenkel, R.; Weikum, G.

    2003-01-01

    Web-based distributed XML query processing has gained in importance in recent years due to the widespread popularity of XML on the Web. Unlike centralized and tightly coupled distributed systems, Web-based distributed database systems are highly unpredictable and uncontrollable, with a rather

  12. Link invariant and $G_2$ web space

    OpenAIRE

    Sakamoto, Takuro; Yonezawa, Yasuyoshi

    2017-01-01

    In this paper, we reconstruct Kuperberg’s $G_2$ web space [5, 6]. We introduce a new web diagram (a trivalent graph with only double edges) and new relations between Kuperberg’s web diagrams and the new web diagram. Using the web diagrams, we give crossing formulas for the $R$-matrices associated to some irreducible representations of $U_q(G_2)$ and calculate $G_2$ quantum link invariants for generalized twist links.

  13. Geospatial Semantics and the Semantic Web

    CERN Document Server

    Ashish, Naveen

    2011-01-01

    The availability of geographic and geospatial information and services, especially on the open Web has become abundant in the last several years with the proliferation of online maps, geo-coding services, geospatial Web services and geospatially enabled applications. The need for geospatial reasoning has significantly increased in many everyday applications including personal digital assistants, Web search applications, local aware mobile services, specialized systems for emergency response, medical triaging, intelligence analysis and more. Geospatial Semantics and the Semantic Web: Foundation

  14. Responsive web design with jQuery

    CERN Document Server

    Carlos, Gilberto

    2013-01-01

    Responsive Web Design with jQuery follows a standard tutorial-based approach, covering various aspects of responsive web design by building a comprehensive website.""Responsive Web Design with jQuery"" is aimed at web designers who are interested in building device-agnostic websites. You should have a grasp of standard HTML, CSS, and JavaScript development, and have a familiarity with graphic design. Some exposure to jQuery and HTML5 will be beneficial but isn't essential.

  15. A Two-Tiered Model for Analyzing Library Web Site Usage Statistics, Part 1: Web Server Logs.

    Science.gov (United States)

    Cohen, Laura B.

    2003-01-01

    Proposes a two-tiered model for analyzing web site usage statistics for academic libraries: one tier for library administrators that analyzes measures indicating library use, and a second tier for web site managers that analyzes measures aiding in server maintenance and site design. Discusses the technology of web site usage statistics, and…

  16. Fuzzy Clustering: An Approachfor Mining Usage Profilesfrom Web

    OpenAIRE

    Ms.Archana N. Boob; Prof. D. M. Dakhane

    2012-01-01

    Web usage mining is an application of data mining technology to mining the data of the web server log file. It can discover the browsing patterns of user and some kind of correlations between the web pages. Web usage mining provides the support for the web site design, providing personalization server and other business making decision, etc. Web mining applies the data mining, the artificial intelligence and the chart technology and so on to the web data and traces users' visiting characteris...

  17. Web sites that work secrets from winning web sites

    CERN Document Server

    Smith, Jon

    2012-01-01

    Leading web site entrepreneur Jon Smith has condensed the secrets of his success into 52 inspiring ideas that even the most hopeless technophobe can implement. The brilliant tips and practical advice in Web sites that work will uplift and transform any website, from the simplest to the most complicated. It deals with everything from fundamentals such as how to assess the effectiveness of a website and how to get a site listed on the most popular search engines to more sophisticated challenges like creating a community and dealing with legal requirements. Straight-talking, practical and humorou

  18. Customisable Scientific Web Portal for Fusion Research

    Energy Technology Data Exchange (ETDEWEB)

    Abla, G; Kim, E; Schissel, D; Flannagan, S [General Atomics, San Diego (United States)

    2009-07-01

    The Web browser has become one of the major application interfaces for remotely participating in magnetic fusion. Web portals are used to present very diverse sources of information in a unified way. While a web portal has several benefits over other software interfaces, such as providing single point of access for multiple computational services, and eliminating the need for client software installation, the design and development of a web portal has unique challenges. One of the challenges is that a web portal needs to be fast and interactive despite a high volume of tools and information that it presents. Another challenge is the visual output on the web portal often is overwhelming due to the high volume of data generated by complex scientific instruments and experiments; therefore the applications and information should be customizable depending on the needs of users. An appropriate software architecture and web technologies can meet these problems. A web-portal has been designed to support the experimental activities of DIII-D researchers worldwide. It utilizes a multi-tier software architecture, and web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services for users to select. Customizable services are: real-time experiment status monitoring, diagnostic data access, interactive data visualization. The web-portal also supports interactive collaborations by providing collaborative logbook, shared visualization and online instant message services. Furthermore, the web portal will provide a mechanism to allow users to create their own applications on the web portal as well as bridging capabilities to external applications such as Twitter and other social networks. In this series of slides, we describe the software architecture of this scientific web portal and our experiences in utilizing web 2.0 technologies. A

  19. Estimating Maintenance Cost for Web Applications

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2016-01-01

    Full Text Available The current paper tackles the issue of determining a method for estimating maintenance costs for web applications. The current state of research in the field of web application maintenance is summarized and leading theories and results are highlighted. The cost of web maintenance is determined by the number of man-hours invested in maintenance tasks. Web maintenance tasks are categorized into content maintenance and technical maintenance. Research is centered on analyzing technical maintenance tasks. The research hypothesis is formulated on the assumption that the number of man-hours invested in maintenance tasks can be assessed based on the web application’s user interaction level, complexity and content update effort. Data regarding the costs of maintenance tasks is collected from 24 maintenance projects implemented by a web development company that tackles a wide area of web applications. Homogeneity and diversity of collected data is submitted for debate by presenting a sample of the data and depicting the overall size and comprehensive nature of the entire dataset. A set of metrics dedicated to estimating maintenance costs in web applications is defined based on conclusions formulated by analyzing the collected data and the theories and practices dominating the current state of research. Metrics are validated with regards to the initial research hypothesis. Research hypothesis are validated and conclusions are formulated on the topic of estimating the maintenance cost of web applications. The limits of the research process which represented the basis for the current paper are enunciated. Future research topics are submitted for debate.

  20. Does AMH Reflect Follicle Number Similarly in Women with and without PCOS?

    Directory of Open Access Journals (Sweden)

    Sverre C Christiansen

    Full Text Available Increased Anti-Mullerian Hormone in polycystic ovary syndrome, may be due to overactive follicles rather than reflect antral follicle count.Does Anti-Mullerian Hormone reflect antral follicle count similarly in women with or without polycystic ovary syndrome or polycystic ovarian morphology?Cross-sectional, case-control.Women who delivered preterm in 1999-2006. For each index woman, a woman with a term delivery was identified.Participation rate was 69%. Between 2006-2008, 262 women were included, and diagnosed to have polycystic ovary syndrome, polycystic ovarian morphology or to be normal controls.Blood tests, a clinical examination and vaginal ultrasound.Anti-Mullerian Hormone/antral follicle count-ratio, SHBG, androstenedione and insulin, to test potential influence on the Anti-Mullerian Hormone/antral follicle count -ratio.Mean Anti-Mullerian Hormone/antral follicle count ratio in women with polycystic ovary syndrome or polycystic ovarian morphology was similar to that of the controls (polycystic ovary syndrome: 1,2 p = 0,10 polycystic ovarian morphology: 1,2, p = 0,27 Controls 1,3. Anti-Mullerian Hormone showed a positive linear correlation to antral follicle count in all groups. Multivariate analysis did not change the results.We confirmed the positive correlation between AMH and follicle count. Anti-Mullerian Hormone seems to be a reliable predictor of antral follicle count, independent of polycystic ovary syndrome diagnosis or ovarian morphology.

  1. Is nursing ready for WebQuests?

    Science.gov (United States)

    Lahaie, Ulysses David

    2008-12-01

    Based on an inquiry-oriented framework, WebQuests facilitate the construction of effective learning activities. Developed by Bernie Dodge and Tom March in 1995 at the San Diego State University, WebQuests have gained worldwide popularity among educators in the kindergarten through grade 12 educational sector. However, their application at the college and university levels is not well documented. WebQuests enhance and promote higher order-thinking skills, are consistent with Bloom's Taxonomy, and reflect a learner-centered instructional methodology (constructivism). They are based on solid theoretical foundations and promote critical thinking, inquiry, and problem solving. There is a role for WebQuests in nursing education. A WebQuest example is described in this article.

  2. The WebQuest: constructing creative learning.

    Science.gov (United States)

    Sanford, Julie; Townsend-Rocchiccioli, Judith; Trimm, Donna; Jacobs, Mike

    2010-10-01

    An exciting expansion of online educational opportunities is occurring in nursing. The use of a WebQuest as an inquiry-based learning activity can offer considerable opportunity for nurses to learn how to analyze and synthesize critical information. A WebQuest, as a constructivist, inquiry-oriented strategy, requires learners to use higher levels of thinking as a means to analyze and apply complex information, providing an exciting online teaching and learning strategy. A WebQuest is an inquiry-oriented lesson format in which most or all of the information learners work with comes from the web. This article provides an overview of the WebQuest as a teaching strategy and provides examples of its use. Copyright 2010, SLACK Incorporated.

  3. Distributed Management of Concurrent Web Service Transactions

    DEFF Research Database (Denmark)

    Alrifai, Mohammad; Dolog, Peter; Balke, Wolf-Tilo

    2009-01-01

    Business processes involve dynamic compositions of interleaved tasks. Therefore, ensuring reliable transactional processing of Web services is crucial for the success of Web service-based B2B and B2C applications. But the inherent autonomy and heterogeneity of Web services render the applicability...... of conventional ACID transaction models for Web services far from being straightforward. Current Web service transaction models relax the isolation property and rely on compensation mechanisms to ensure atomicity of business transactions in the presence of service failures. However, ensuring consistency...... in the open and dynamic environment of Web services, where interleaving business transactions enter and exit the system independently, remains an open issue. In this paper, we address this problem and propose an architecture that supports concurrency control on the Web services level. An extension...

  4. Penilaian Risiko Aplikasi Web Menggunakan Model DREAD

    Directory of Open Access Journals (Sweden)

    Didit Suprihanto

    2016-01-01

    Full Text Available Application that  is developed by web based, beside has surplus in WWW technology, it has susceptibility side that can be threat too. Susceptibility generate risk and can bring out big trouble even effect big disadvantage. The goal of this research is design and build document risk assessment system of threat level and prevention advice. It use DREAD model as method to solve trouble by giving qualified information. This information are used to produce risk level in web application. The result of this research is web application risk assessment system by using DREAD model to know risk threat level and equate perception of web threat risk to application developer, minimize of threat risk and maximize performance of web application.   Keywords : DREAD model, web threat risk, web risk assessment system

  5. Responsive web design with AngularJS

    CERN Document Server

    Patel, Sandeep Kumar

    2014-01-01

    If you are an AngularJS developer who wants to learn about responsive web application development, this book is ideal for you. Responsive Web Design with AngularJS is intended for web developers or designers with a basic knowledge of HTML, CSS, and JavaScript.

  6. Finding pages on the unarchived Web

    NARCIS (Netherlands)

    J. Kamps; A. Ben-David; H.C. Huurdeman; A.P. de Vries (Arjen); T. Samar (Thaer)

    2014-01-01

    htmlabstractWeb archives preserve the fast changing Web, yet are highly incomplete due to crawling restrictions, crawling depth and frequency, or restrictive selection policies-most of the Web is unarchived and therefore lost to posterity. In this paper, we propose an approach to recover significant

  7. Web 2.0 in e-Learning

    Directory of Open Access Journals (Sweden)

    M. Tariq Banday

    2013-10-01

    Full Text Available Web 2.0 tools have created fresh opportunities for governments, education, businesses and individuals to enhance efficiency and improve effectiveness while executing respective professional duties. The key features of these tools include online character and access through a web browser, supportive for open content licenses, open sharing and social interaction, and often free to use or support free features. These have created novel prospects for teachers to combine face-to-face teaching and online materials via social media such as discussion forums, blogs and wikis. The web 2.0 educational design is based on socio-cultural learning theories such as interaction, joint creation of content, critical thinking, learning by doing and collaboration. This paper makes an appraisal of ICT adoption in education, emergence of Web, improvements in Web and its effect on the e-Learning. It explains gradual integration of ICT into education through various stages. The paper presents the content and communication dimensions of e-learning for its classification. It discusses various opportunities created by Web 2.0 tools in education for effective teacher-learner, learner-learner and teacher-teacher communication, interaction and collaboration. It presents various cases and projects involving use of some Web 2.0 tools for enhancing learning. Furthermore, it lists some challenges for successful implementation of e-learning through Web 2.0 tools and discusses some possible solutions for its control.

  8. Web-Based Learning Support System

    Science.gov (United States)

    Fan, Lisa

    Web-based learning support system offers many benefits over traditional learning environments and has become very popular. The Web is a powerful environment for distributing information and delivering knowledge to an increasingly wide and diverse audience. Typical Web-based learning environments, such as Web-CT, Blackboard, include course content delivery tools, quiz modules, grade reporting systems, assignment submission components, etc. They are powerful integrated learning management systems (LMS) that support a number of activities performed by teachers and students during the learning process [1]. However, students who study a course on the Internet tend to be more heterogeneously distributed than those found in a traditional classroom situation. In order to achieve optimal efficiency in a learning process, an individual learner needs his or her own personalized assistance. For a web-based open and dynamic learning environment, personalized support for learners becomes more important. This chapter demonstrates how to realize personalized learning support in dynamic and heterogeneous learning environments by utilizing Adaptive Web technologies. It focuses on course personalization in terms of contents and teaching materials that is according to each student's needs and capabilities. An example of using Rough Set to analyze student personal information to assist students with effective learning and predict student performance is presented.

  9. Development, implementation and pilot evaluation of a Web-based Virtual Patient Case Simulation environment – Web-SP

    Directory of Open Access Journals (Sweden)

    Boberg Jonas

    2006-02-01

    Full Text Available Abstract Background The Web-based Simulation of Patients (Web-SP project was initiated in order to facilitate the use of realistic and interactive virtual patients (VP in medicine and healthcare education. Web-SP focuses on moving beyond the technology savvy teachers, when integrating simulation-based education into health sciences curricula, by making the creation and use of virtual patients easier. The project strives to provide a common generic platform for design/creation, management, evaluation and sharing of web-based virtual patients. The aim of this study was to evaluate if it was possible to develop a web-based virtual patient case simulation environment where the entire case authoring process might be handled by teachers and which would be flexible enough to be used in different healthcare disciplines. Results The Web-SP system was constructed to support easy authoring, management and presentation of virtual patient cases. The case authoring environment was found to facilitate for teachers to create full-fledged patient cases without the assistance of computer specialists. Web-SP was successfully implemented at several universities by taking into account key factors such as cost, access, security, scalability and flexibility. Pilot evaluations in medical, dentistry and pharmacy courses shows that students regarded Web-SP as easy to use, engaging and to be of educational value. Cases adapted for all three disciplines were judged to be of significant educational value by the course leaders. Conclusion The Web-SP system seems to fulfil the aim of providing a common generic platform for creation, management and evaluation of web-based virtual patient cases. The responses regarding the authoring environment indicated that the system might be user-friendly enough to appeal to a majority of the academic staff. In terms of implementation strengths, Web-SP seems to fulfil most needs from course directors and teachers from various educational

  10. Web Auctions in Europe

    NARCIS (Netherlands)

    A. Pouloudi; J. Paarlberg; H.W.G.M. van Heck (Eric)

    2001-01-01

    textabstractThis paper argues that a better understanding of the business model of web auctions can be reached if we adopt a broader view and provide empirical research from different sites. In this paper the business model of web auctions is refined into four dimensions. These are auction model,

  11. Here be web proxies

    DEFF Research Database (Denmark)

    Weaver, Nicholas; Kreibich, Christian; Dam, Martin

    2014-01-01

    ,000 clients that include a novel proxy location technique based on traceroutes of the responses to TCP connection establishment requests, which provides additional clues regarding the purpose of the identified web proxies. Overall, we see 14% of Netalyzr-analyzed clients with results that suggest the presence...... of web proxies....

  12. Info.cern.ch returns to the Web

    CERN Document Server

    2006-01-01

    First web address is reincarnated as a historical reference on the birth of the Web. Tim Berners-Lee, inventor of the Web, with one of the first Web pages on his computer. CERN invites you to take a virtual trip back in time and have a look at what the very first URL, which led to a revolution of the way we communicate and share information, was all about. The original web server, whose address was info.cern.ch, centred on information regarding the WorldWideWeb (WWW) project. Visitors could learn more about hypertext, technical details for creating one's own webpage, and even an explanation on how to search the Web for information-something 5 year-olds of today have mastered since it all started 17 years ago. Now info.cern.ch has been re-launched with a much brighter façade and a focus on the ideas that inspired this new wave of technology. The first browser created by Tim Berners-Lee, inventor of the Web, contained just about everything we see today on a web browser, including graphics, menus, layouts and...

  13. A Runtime System for Interactive Web Services

    DEFF Research Database (Denmark)

    Brabrand, Claus; Møller, Anders; Sandholm, Anders

    1999-01-01

    Interactive web services are increasingly replacing traditional static web pages. Producing web services seems to require a tremendous amount of laborious low-level coding due to the primitive nature of CGI programming. We present ideas for an improved runtime system for interactive web services...... built on top of CGI running on virtually every combination of browser and HTTP/CGI server. The runtime system has been implemented and used extensively in , a tool for producing interactive web services....

  14. Discovering More Accurate Frequent Web Usage Patterns

    OpenAIRE

    Bayir, Murat Ali; Toroslu, Ismail Hakki; Cosar, Ahmet; Fidan, Guven

    2008-01-01

    Web usage mining is a type of web mining, which exploits data mining techniques to discover valuable information from navigation behavior of World Wide Web users. As in classical data mining, data preparation and pattern discovery are the main issues in web usage mining. The first phase of web usage mining is the data processing phase, which includes the session reconstruction operation from server logs. Session reconstruction success directly affects the quality of the frequent patterns disc...

  15. Context Aware Concurrent Execution Framework for Web Browser

    DEFF Research Database (Denmark)

    Saeed, Aamir; Erbad, Aiman Mahmood; Olsen, Rasmus Løvenstein

    Computing hungry multimedia web applications need to efficiently utilize the device resources. HTML5 web workers is a non-sharing concurrency platform that enables multimedia web application to utilize the available multi-core hardware. HTML5 web workers are implemented by major browser vendors...... to facilitate concurrent execution in web clients and enhance the quality of ambitious web applications. The concurrent execution in web workers allows parallel processing using available cores at the expense of communication overhead and extra computation. The benefits of concurrent execution can be maximized...... by balancing load across workers/CPU cores. This work presents load-balancing algorithms between web workers using parameters such as scheduler throughput, computation priority and game entity locality. An award-winning web-based multimedia game (raptjs.com) is used to test the performance of the load balance...

  16. The Spine of the Cosmic Web

    NARCIS (Netherlands)

    Aragón-Calvo, Miguel A.; Platen, Erwin; van de Weijgaert, Rien; Szalay, Alexander S.

    2010-01-01

    We present the SpineWeb framework for the topological analysis of the Cosmic Web and the identification of its walls, filaments, and cluster nodes. Based on the watershed segmentation of the cosmic density field, the SpineWeb method invokes the local adjacency properties of the boundaries between

  17. The Spine of the Cosmic Web

    NARCIS (Netherlands)

    Aragón-Calvo, Miguel A.; Platen, Erwin; van de Weijgaert, Rien; Szalay, Alexander S.

    We present the SpineWeb framework for the topological analysis of the Cosmic Web and the identification of its walls, filaments, and cluster nodes. Based on the watershed segmentation of the cosmic density field, the SpineWeb method invokes the local adjacency properties of the boundaries between

  18. Using centrality to rank web snippets

    NARCIS (Netherlands)

    Jijkoun, V.; de Rijke, M.; Peters, C.; Jijkoun, V.; Mandl, T.; Müller, H.; Oard, D.W.; Peñas, A.; Petras, V.; Santos, D.

    2008-01-01

    We describe our participation in the WebCLEF 2007 task, targeted at snippet retrieval from web data. Our system ranks snippets based on a simple similarity-based centrality, inspired by the web page ranking algorithms. We experimented with retrieval units (sentences and paragraphs) and with the

  19. Community food webs data and theory

    CERN Document Server

    Cohen, Joel E; Newman, Charles M

    1990-01-01

    Food webs hold a central place in ecology. They describe which organisms feed on which others in natural habitats. This book describes recently discovered empirical regularities in real food webs: it proposes a novel theory unifying many of these regularities, as well as extensive empirical data. After a general introduction, reviewing the empirical and theoretical discoveries about food webs, the second portion of the book shows that community food webs obey several striking phenomenological regularities. Some of these unify, regardless of habitat. Others differentiate, showing that habitat significantly influences structure. The third portion of the book presents a theoretical analysis of some of the unifying empirical regularities. The fourth portion of the book presents 13 community food webs. Collected from scattered sources and carefully edited, they are the empirical basis for the results in the volume. The largest available set of data on community food webs provides a valuable foundation for future s...

  20. Caught in the Web

    Energy Technology Data Exchange (ETDEWEB)

    Gillies, James

    1995-06-15

    The World-Wide Web may have taken the Internet by storm, but many people would be surprised to learn that it owes its existence to CERN. Around half the world's particle physicists come to CERN for their experiments, and the Web is the result of their need to share information quickly and easily on a global scale. Six years after Tim Berners-Lee's inspired idea to marry hypertext to the Internet in 1989, CERN is handing over future Web development to the World-Wide Web Consortium, run by the French National Institute for Research in Computer Science and Control, INRIA, and the Laboratory for Computer Science of the Massachusetts Institute of Technology, MIT, leaving itself free to concentrate on physics. The Laboratory marked this transition with a conference designed to give a taste of what the Web can do, whilst firmly stamping it with the label ''Made in CERN''. Over 200 European journalists and educationalists came to CERN on 8 - 9 March for the World-Wide Web Days, resulting in wide media coverage. The conference was opened by UK Science Minister David Hunt who stressed the importance of fundamental research in generating new ideas. ''Who could have guessed 10 years ago'', he said, ''that particle physics research would lead to a communication system which would allow every school to have the biggest library in the world in a single computer?''. In his introduction, the Minister also pointed out that ''CERN and other basic research laboratories help to break new technological ground and sow the seeds of what will become mainstream manufacturing in the future.'' Learning the jargon is often the hardest part of coming to grips with any new invention, so CERN put it at the top of the agenda. Jacques Altaber, who helped introduce the Internet to CERN in the early 1980s, explained that without the Internet, the Web couldn't exist. The Internet began as a US Defense Department research project in the 1970s and has grown into a global network-ofnetworks linking some