WorldWideScience

Sample records for prep class pass

  1. Mentoring clinical ladder advancement with a facilitated prep class.

    Science.gov (United States)

    Winslow, Susan A; Blankenship, Jean

    2007-01-01

    The authors describe a strategy for encouraging participation and overcoming reluctance of staff to participate in an optional professional advancement career ladder program. A facilitated prep class in a computer skills laboratory provides nurses with the framework for completing application requirements in a casual, supportive atmosphere.

  2. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Directory of Open Access Journals (Sweden)

    Daniel A Felix

    2010-04-01

    Full Text Available Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is

  3. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Science.gov (United States)

    Felix, Daniel A; Aboobaker, A Aziz

    2010-04-22

    Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi) animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation) to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is required for

  4. 76 FR 56354 - Proposed Amendment of Class E Airspace; Anaktuvuk Pass, AK

    Science.gov (United States)

    2011-09-13

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Anaktuvuk Pass, AK...: This action proposes to revise Class E airspace at Anaktuvuk Pass, AK. The creation of two standard instrument approach procedures at the Anaktuvuk Pass Airport has made this action necessary to enhance...

  5. 76 FR 78144 - Amendment of Class E Airspace; Anaktuvuk Pass, AK

    Science.gov (United States)

    2011-12-16

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Anaktuvuk Pass, AK AGENCY... airspace at Anaktuvuk Pass Airport, Anaktuvuk Pass, AK. The creation of two standard instrument approach... Federal Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at Anaktuvuk Pass,...

  6. Improving Classroom Engagement among High School Students with Disruptive Behavior: Evaluation of the Class Pass Intervention

    Science.gov (United States)

    Collins, Tai A.; Cook, Clayton R.; Dart, Evan H.; Socie, Diana G.; Renshaw, Tyler L.; Long, Anna C.

    2016-01-01

    Off-task and disruptive classroom behaviors have a negative impact on the learning environment and present a unique challenge for teachers to address. The aim of this study was to evaluate the Class Pass Intervention (CPI) as a behavior management strategy for secondary students with disruptive classroom behavior. The CPI consists of providing…

  7. Evaluation of the Class Pass Intervention for Typically Developing Students with Hypothesized Escape-Motivated Disruptive Classroom Behavior

    Science.gov (United States)

    Cook, Clayton R.; Collins, Tai; Dart, Evan; Vance, Michael J.; McIntosh, Kent; Grady, Erin A.; DeCano, Policarpio

    2014-01-01

    The aim of this study was to evaluate the Class Pass Intervention (CPI) as a secondary intervention for typically developing students with escape-motivated disruptive classroom behavior. The CPI consists of providing students with passes that they can use to appropriately request a break from an academic task to engage in a preferred activity for…

  8. ACT Verbal Prep Course

    CERN Document Server

    Standridge, Nathan

    2012-01-01

    Comprehensive Prep for ACT Verbal. Every year, students pay 1,000 and more to test prep companies to prepare for the verbal sections of the ACT. Now you can get the same preparation in a book. The verbal sections are not easy. There is no quick fix that will allow you to "beat" the ACT, but it is very learnable. If you study hard and master the techniques in this book, your score will improve-significantly. The ACT cannot be "beaten." But it can be mastered-through hard work, analytical thought, and by training yourself to think like a test writer. Many of the exercises in this book are design

  9. SAT math prep course

    CERN Document Server

    Kolby, Jeff

    2011-01-01

    Comprehensive Prep for SAT Math Every year, students pay 1,000 and more to test prep companies to prepare for the math section of the new SAT. Now you can get the same preparation in a book. Features: * Comprehensive Review: Twenty-three chapters provide complete review of SAT math. * Practice: Includes 164 examples and more than 500 exercises! Arranged from easy to medium to hard to very hard. * Diagnostic Test: The diagnostic test measures your strengths and weaknesses and directs you to areas you need to study more. * Performance: If your target is a 700+ score, this is the book!

  10. A class of high-pass digital MTI filters with nonuniform PRF

    NARCIS (Netherlands)

    Prinsen, P.J.A.

    1973-01-01

    A class of digital feed-forward filters is developed, satisfying the requirement of a maximally flat stopband characteristic at zero frequency if the pulse-repetition frequency is modulated. A simple algorithm is given to obtain the filter coefficients. Some properties are summarized

  11. PMP exam prep

    CERN Document Server

    Mulcahy, Rita

    2013-01-01

    This book has been FULLY updated to reflect PMI's changes to the PMP exam, and should be used to prepare for all PMP exams delivered on or after July 30th of 2013. Can you imagine valuing a book so much that you send the author a Thank You letter? Hundreds of thousands of project managers know and understand why PMP Exam Prep is a worldwide best-seller. Years of PMP exam preparation experience, endless hours of ongoing research, interviews with project managers who failed the exam to identify gaps in their knowledge, and a razor-sharp focus on making sure project managers don't waste a single minute of their time studying are THE reasons this book is the best-selling PMP exam preparation guide in the world. PMP Exam Prep, Eighth Edition contains hundreds of updates and improvements from previous editions--including new exercises and sample questions never before in print. Offering hundreds of sample questions, critical time-saving tips plus games and activities available nowhere else, this book will help y...

  12. Tech Prep and the Rural Context.

    Science.gov (United States)

    Roth, Gene L.

    1996-01-01

    Discusses implementation of tech prep in rural areas and notes that relatively little research has been done on behalf of small town schools. Teachers' comments regarding tech prep implementation provide additional insight into the situation. (JOW)

  13. Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.

    Directory of Open Access Journals (Sweden)

    Elisa Bernardi

    Full Text Available Prep1 is a developmentally essential TALE class homeodomain transcription factor. In zebrafish and mouse, Prep1 is already ubiquitously expressed at the earliest stages of development, with important tissue-specific peculiarities. The Prep1 gene in mouse is developmentally essential and has haploinsufficient tumor suppressor activity [1]. We have determined the human Prep1 transcription start site (TSS by primer extension analysis and identified, within 20 bp, the transcription start region (TSR of the zebrafish Prep1.1 promoter. The functions of the zebrafish 5' upstream sequences were analyzed both by transient transfections in Hela Cells and by injection in zebrafish embryos. This analysis revealed a complex promoter with regulatory sequences extending up to -1.8, possibly -5.0 Kb, responsible for tissue specific expression. Moreover, the first intron contains a conserved tissue-specific enhancer both in zebrafish and in human cells. Finally, a two nucleotides mutation of an EGR-1 site, conserved in all species including human and zebrafish and located at a short distance from the TSS, destroyed the promoter activity of the -5.0 Kb promoter. A transgenic fish expressing GFP under the -1.8 Kb zebrafish promoter/enhancer co-expressed GFP and endogenous Prep1.1 during embryonic development. In the adult fish, GFP was expressed in hematopoietic regions like the kidney, in agreement with the essential function of Prep1 in mouse hematopoiesis. Sequence comparison showed conservation from man to fish of the sequences around the TSS, within the first intron enhancer. Moreover, about 40% of the sequences spread throughout the 5 Kbof the zebrafish promoter are concentrated in the -3 to -5 Kb of the human upstream region.

  14. An Exploratory Investigation of the Promoting Responsibility through Education and Prevention (PREP) after School Program for African American At-Risk Elementary School Students

    Science.gov (United States)

    Sale, Elizabeth; Weil, Virginia; Kryah, Rachel

    2012-01-01

    The promoting responsibility through education and prevention (PREP) program is an after school substance abuse and violence prevention program for at-risk fourth and fifth grade youths in St. Louis, Missouri. Staffed by licensed clinical social workers and professional volunteers, PREP offers cultural cooking classes, yoga, and art as well as…

  15. PrEP: controversy, agency and ownership

    National Research Council Canada - National Science Library

    Cairns, Gus P; Race, Kane; Goicochea, Pedro

    2016-01-01

    Pre‐exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need...

  16. Pre-Exposure Prophylaxis (PrEP)

    Science.gov (United States)

    ... Sites Podcasts QR Codes RSS Feeds Social Bookmarking Social Network Sites Text Messaging Twitter Video Games Video Sharing ... PrEP be considered for people who are HIV-negative and at very high risk for HIV infection . ...

  17. Prep/Tech: Volume 1, No. 1, Youth on homelessness

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    PREP/TECH is a skill development, academic enrichment program of U. of Toledo in Toledo OH and The Engineers Foundation of Ohio; it addresses the mathematics, science, language, and intellectual needs of about 100 African-American and Hispanic-American 7th, 8th, and 9th graders in Toledo. This summer, after 3 weeks of classes, the 80 students returned for a second 3 week session and were divided into two groups, one studying the growing problem of homelessness in America. This group researched and published a pamphlet on homelessness. This report is divided into: myths, causes, descriptions, and solutions. Finally, a brief account is given of the homelessness project.

  18. PrEP: controversy, agency and ownership

    OpenAIRE

    Cairns, Gus P; Kane Race; Pedro Goicochea

    2016-01-01

    Pre-exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need of it. These controversies extend beyond the intrinsically complex issues of making it available. In this commentary, some of the possible roots of the air of dissent and drama that accompanies PrEP are explored. The similarities between the controversies that dogged the earliest human tr...

  19. Planning a Tech Prep Program in Hospitality. Final Report.

    Science.gov (United States)

    Chicago City Colleges, IL. Chicago City-Wide Coll.

    A project conducted to establish tech prep articulation training agreements between City Colleges of Chicago and several public secondary schools is described in this report. Project activities were as follows: (1) developed a handbook to define the tech prep experience and guide committee members on how tech prep can be a valuable asset to…

  20. PrEP (Pre-Exposure Prophylaxis) 101

    Science.gov (United States)

    ... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

  1. Muley Pass

    OpenAIRE

    Conkey, Ross

    2013-01-01

    Muley Pass tells the story of a town that's not really a town. It was built as a live-on movie set for a western tv show fifty years ago. But, when the show left forty years ago, Slug McLeod didn't. As de facto caretaker, he has to find a way to save the town from imminent destruction in service to High Speed rail - including stepping out of the 1890s into modern day Hollywood.

  2. Information Technology Administrator’s Instruction Manual for the Personal Academic Strategies for Success (PASS) Tool, With Subcomponent Academic Class Composite Tool (AC2T)

    Science.gov (United States)

    2013-12-01

    information was generated through evidence-based research and statistical regression modeling with data from 579 68W AIT students. The same tool contains a...the best fit model of academic achievement predictor variables was identified. The final regression model then formed the basis for both the PASS and...passwords: (a) IT Admin: PassTool10!! (b) VBA Window (Code): PASStoolAdmin (c) Back End: PASStoolBE2010!! (d) First Researcher Admin: SuperAdmin12%^ 2

  3. SKILL PREP Program for American Indian Students. Final report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    McCulloh, S.; Huebner, P.

    1995-10-01

    The Scientific Knowledge for Indian Learning and Leadership (SKILL) precollege college program of the South Dakota School of Mines and Technology concluded the 1994 PREP program on July 22, 1994. The program graduated 22 students from the 4-week residential math/science program for American Indian students. Primary academic focus was physics (30 hours); each student was given a bicycle to solve problems on angular momentum and mechanical advantage. Mathematical calculations and problem solving exercises were done in mathematics class (20 hours). Preliminary results in math, physics, and geology show dramatic increases in student achievement over the 4- week period. The program paired every two students with a faculty member or research scientist, and each team completed a research project.

  4. How To Start a Prep Physics Course

    Science.gov (United States)

    Wall, Jesse D.

    1998-04-01

    At City College, we follow our mother institution, the University of California at Berkeley, in that we require high school physics as a prerequisite for general college physics and then provide a one-semester prep physics course as an alternative to meet this prerequisite. Many people have asked me how they can start such a course. In traveling about on my sabbatical, doing Physics Of Magic (1) at various schools, I have observed how various schools implement this prerequisite course. I will discuss my observations.

  5. Passing on power & voice

    DEFF Research Database (Denmark)

    Noer, Vibeke Røn; Nielsen, Cathrine Sand

    2014-01-01

    . The education lasts for 3,5 years and the landmark of the educational model is the continuously shifts between teaching in classroom and teaching in clinical practice. Clinical teaching takes place at approved clinical placement institutions in hospitals and in the social and health care services outside...... intention of gaining knowledge about other possible ways to perform the education. The class, named the E-class, followed what in the field was named ‘an experimental educational model based on experienced-based learning’ (Nielsen et al. 2011). The experiential educational model is argued as an experiment.......aspx Higher degree of student involvement in planning as well as teaching was in the field presented as a part of ‘the overall educational approach’. In the course ‘Acute, Critical Nursing & Terminal, Palliative Care’ this was transferred into an innovative pedagogy with intend to pass on power and voice...

  6. Review of HIV Pre exposure prophylaxis (PrEP) and example of HIV PrEP Toolkit

    Science.gov (United States)

    2017-08-28

    Interventions Aim: to reduce the efficiency of transmission or to shorten the duration of infectiousness Usexual Partners U Sharing Needles Older Age...Program HIV PrEP Portfolio - DoD-wide PrEP experience to date (Beckett, Okulicz, Blaylock/Garges, MHRP/WRAIR*) • Analysis of all DoD beneficiaries

  7. Distribution, nesting activities, and age-class of territorial pairs of golden eagles at the Altamont Pass Wind Resource Area, California, 2014–16

    Science.gov (United States)

    Kolar, Patrick S.; Wiens, J. David

    2017-03-22

    The substantial numbers of golden eagles (Aquila chrysaetos) killed by collisions with oldgeneration wind turbines each year at the Altamont Pass Wind Resource Area (APWRA) in California has been well documented from previous studies. Few eagle nests have been documented in the APWRA, however, and adults and subadults 3+ years of age killed by turbines were generally not associated with nearby territories. We searched a subset of randomly selected survey plots for territorial pairs of golden eagles and associated nesting attempts within the APWRA as part of a broader investigation of population dynamics in the surrounding northern Diablo Range. In contrast to limited historical observations from 1988 to 2013, our surveys documented up to 15 territorial pairs within 3.2 kilometers (km) of wind turbines at the APWRA annually, 9 of which were not previously documented or only observed intermittently during historical surveys. We found evidence of nesting activity by adult pairs at least once during our study at six of these territories. We also determined that 23–36 percent of territories identified within 3.2 km of the APWRA had a subadult pair member, but that no pairs with a subadult member attempted to nest. These data will be useful to developers, wildlife managers, and future raptor studies in the area to evaluate and minimize the potential effects of wind energy or other development activities on previously unknown territorial pairs in the area.

  8. Potential reduced exposure products (PREPs) in industry trial testimony.

    Science.gov (United States)

    Wayne, Geoffrey Ferris

    2006-12-01

    To identify patterns in trial testimony that may reflect on the intentions or expectations of tobacco manufacturers with regard to the introduction of potential reduced exposure products (PREPs). Research was conducted using the Deposition and Trial Testimony Archive (DATTA) collection of trial testimony and depositions housed online at Tobacco Documents Online (www.tobaccodocuments.org). Relevant testimony was identified through full-text searches of terms indicating PREPs or harm reduction strategies. The role and function of PREPs in testimony were classified according to common and contrasting themes. These were analysed in the context of broader trial arguments and against changes in time period and the market. Analysis of testimony suggests that the failure of PREPs in the market tempered initial industry enthusiasm and made protection of the conventional cigarette market its major priority. The "breakthrough" character of PREPs has been de-emphasised, with trial arguments instead positioning PREPs as simply another choice for consumers. This framework legitimises the sale of conventional brands, and shifts the responsibility for adoption of safer products from the manufacturer to the consumer. Likewise, testimony has abandoned earlier dramatic health claims made with regard to PREPs, which had undermined industry arguments regarding efforts to reduce harm in conventional products. More recent testimony advocates the broad acceptance of independent guidelines that would validate use of health claims and enable the industry to market PREPs to consumers. Trial testimony reflects the changing role and positioning of PREPs by the tobacco industry. The findings are of particular importance with regard to future evaluation and potential regulation of reduced harm products.

  9. The world-class Howard's Pass SEDEX Zn-Pb district, Selwyn Basin, Yukon. Part II: the roles of thermochemical and bacterial sulfate reduction in metal fixation

    Science.gov (United States)

    Gadd, Michael G.; Layton-Matthews, Daniel; Peter, Jan M.; Paradis, Suzanne; Jonasson, Ian R.

    2017-03-01

    The Howard's Pass district of sedimentary exhalative (SEDEX) Zn-Pb deposits is located in Yukon Territory and comprises 14 Zn-Pb deposits that contain an estimated 400.7 Mt of sulfide mineralization grading 4.5 % Zn and 1.5 % Pb. Mineralization is hosted in carbonaceous and calcareous and, to a lesser extent, siliceous mudstones. Pyrite is a minor but ubiquitous mineral in the host rocks stratigraphically above, within, and below mineralization. Petrographic analyses reveal that pyrite has a complex and protracted growth history, preserving multiple generations of pyrite within single grains. Sulfur isotope analysis of paragenetically complex pyrite by secondary ion mass spectrometry (SIMS) reveals that sulfur isotope compositions vary with textural zonation. Within the Zn-Pb deposits, framboidal pyrite is the earliest pyrite generation recognized, and this exclusively has negative δ34S values (mean = -16.6 ± 4.1 ‰; n = 55), whereas paragenetically later pyrite and galena possess positive δ34S values (mean = 29.1 ± 7.5 and 22.4 ± 3.0 ‰, n = 13 and 13, respectively). Previous studies found that sphalerite and galena mineral separates have exclusively positive δ34S values (mean = 16.8 ± 3.3 and 12.7 ± 2.8 ‰, respectively; Goodfellow and Jonasson 1986). These distinct sulfur isotope values are interpreted to reflect varying contributions of bacterially reduced seawater sulfate (negative; framboidal pyrite) and thermochemically reduced seawater sulfate and/or hydrothermal sulfate (positive; galena, sphalerite, later forms of pyrite). Textural evidence indicates that framboidal pyrite predates galena and sphalerite deposition. Collectively, the in situ and bulk sulfur isotope data are much more complex than δ34S values permitted by prevailing genetic models that invoke only biogenically reduced sulfur and coeval deposition of galena, sphalerite, and framboidal pyrite within a euxinic water column, and we present several lines of evidence that argue

  10. The world-class Howard's Pass SEDEX Zn-Pb district, Selwyn Basin, Yukon. Part II: the roles of thermochemical and bacterial sulfate reduction in metal fixation

    Science.gov (United States)

    Gadd, Michael G.; Layton-Matthews, Daniel; Peter, Jan M.; Paradis, Suzanne; Jonasson, Ian R.

    2016-07-01

    The Howard's Pass district of sedimentary exhalative (SEDEX) Zn-Pb deposits is located in Yukon Territory and comprises 14 Zn-Pb deposits that contain an estimated 400.7 Mt of sulfide mineralization grading 4.5 % Zn and 1.5 % Pb. Mineralization is hosted in carbonaceous and calcareous and, to a lesser extent, siliceous mudstones. Pyrite is a minor but ubiquitous mineral in the host rocks stratigraphically above, within, and below mineralization. Petrographic analyses reveal that pyrite has a complex and protracted growth history, preserving multiple generations of pyrite within single grains. Sulfur isotope analysis of paragenetically complex pyrite by secondary ion mass spectrometry (SIMS) reveals that sulfur isotope compositions vary with textural zonation. Within the Zn-Pb deposits, framboidal pyrite is the earliest pyrite generation recognized, and this exclusively has negative δ34S values (mean = -16.6 ± 4.1 ‰; n = 55), whereas paragenetically later pyrite and galena possess positive δ34S values (mean = 29.1 ± 7.5 and 22.4 ± 3.0 ‰, n = 13 and 13, respectively). Previous studies found that sphalerite and galena mineral separates have exclusively positive δ34S values (mean = 16.8 ± 3.3 and 12.7 ± 2.8 ‰, respectively; Goodfellow and Jonasson 1986). These distinct sulfur isotope values are interpreted to reflect varying contributions of bacterially reduced seawater sulfate (negative; framboidal pyrite) and thermochemically reduced seawater sulfate and/or hydrothermal sulfate (positive; galena, sphalerite, later forms of pyrite). Textural evidence indicates that framboidal pyrite predates galena and sphalerite deposition. Collectively, the in situ and bulk sulfur isotope data are much more complex than δ34S values permitted by prevailing genetic models that invoke only biogenically reduced sulfur and coeval deposition of galena, sphalerite, and framboidal pyrite within a euxinic water column, and we present several lines of evidence that argue

  11. PrEP implementation research in Africa: what is new?

    Directory of Open Access Journals (Sweden)

    Frances M Cowan

    2016-10-01

    Full Text Available Introduction: Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM, transgender women and injection drug users are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion: In each of the target populations, there are overarching issues related to (i creating demand for PrEP, (ii addressing supply-side issues and (iii providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely

  12. AirfoilPrep.py Documentation: Release 0.1.0

    Energy Technology Data Exchange (ETDEWEB)

    Ning, S. A. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-09-01

    AirfoilPrep.py provides functionality to preprocess aerodynamic airfoil data. Essentially, the module is an object oriented version of the AirfoilPrep spreadsheet with additional functionality and is written in the Python language. It allows the user to read in two-dimensional aerodynamic airfoil data, apply three-dimensional rotation corrections for wind turbine applications, and extend the datato very large angles of attack. This document discusses installation, usage, and documentation of the module.

  13. Civil & Military Operations: Evolutionary Prep Steps to Pass Smart Power Current Limitations

    Science.gov (United States)

    2011-06-01

    for learning what you needed to know to evaluate baseball players and baseball games .” (p. 68) – to look for new knowledge on the subject being...of his Ender Series of warfare and future of humanity. “The route of war might succeed for a time – and the operative word in “might,” since...unfair game . W.W. Norton & Company, Inc., New York:NY, 2003. (Mehta, 2011) – Mehta, Seema, Giffords’ surgeon trained on the battlefield. Los Angeles

  14. PREP advertisement features affect smokers' beliefs regarding potential harm.

    Science.gov (United States)

    Strasser, A A; Tang, K Z; Tuller, M D; Cappella, J N

    2008-09-01

    The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. To determine the effect of altering advertisement features on smokers' beliefs of the harm exposure from a PREP. A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a "red" condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a "no text" condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using "incorrect," "unsure" and "correct" as outcomes, and advertisement type and covariates as predictors, was used for analyses. Participants randomised to the "no text" advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, are healthier and make smoking safer. Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising.

  15. NEXT GENERATION ORAL PrEP: BEYOND TENOFOVIR

    Science.gov (United States)

    Abraham, Bisrat K.; Gulick, Roy

    2013-01-01

    Purpose Clinical trials of oral pre-exposure prophylaxis (PrEP) have focused testing on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone) and FTC may select for drug resistance. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV prevention. Recent Findings Several drug characteristics are important to consider when selecting agents for PrEP with the most critical being safety, tolerability, adequate penetration into target tissues, prevention of HIV infection, and long lasting activity with convenient dosing. With these factors in mind, we review several potentially useful agents for PrEP. The first group includes drugs that are already FDA-approved (maraviroc, raltegravir) with attributes that make them attractive for PrEP. The second groups of drugs include investigational agents with long-lasting activities that are being developed in parenteral form (rilpivirine-long acting, S/GSK 1265744, ibalizumab). Summary Current research suggests there will be a broader array of PrEP drugs to choose from in the near future, thereby giving clinicians the flexibility to select agents that best suit the needs of their patient population. PMID:23032733

  16. Passing the English as a second language (ESL) supplemental texes exam keys to certification and language proficient learners

    CERN Document Server

    Wilmore, Elaine L

    2014-01-01

    Master the TExES with down-to-earth test prep strategies ESL certification is attainable if one understands the domains and competencies represented in the test and masters test prep skills. Dr. Elaine Wilmore, known for her popular TExES preparation seminars, synthesizes her knowledge and experiences and gives readers a practical approach to passing the ESL Supplemental Exam. Written in a conversational tone, the book uses real examples to help readers connect theory with actual practice and offers: Thorough discussions of relevant concepts related to domains and competencies Tables and graph

  17. Passing the English as a second language (ESL) supplemental texes exam keys to certification and language proficient learners

    CERN Document Server

    Wilmore, Elaine L

    2014-01-01

    Master the TExES with down-to-earth test prep strategies ESL certification is attainable if one understands the domains and competencies represented in the test and masters test prep skills. Dr. Elaine Wilmore, known for her popular TExES preparation seminars, synthesizes her knowledge and experiences and gives readers a practical approach to passing the ESL Supplemental Exam. Written in a conversational tone, the book uses real examples to help readers connect theory with actual practice and offers: Thorough discussions of relevant concepts related to domains and competencies Tables and graph

  18. New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA

    Science.gov (United States)

    Zucchelli, Chiara; Ferrari, Elena; Blasi, Francesco; Musco, Giovanna; Bruckmann, Chiara

    2017-01-01

    PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA binding. The kinetic parameters for DNA binding of individual PREP1 and PBX1 HDs, and of their combination, show that isolated PREP1 and PBX1 HDs bind to DNA in a cooperative manner. A novel PREP1 motif, flanking the HD at the C-terminus, is required for cooperativity. PMID:28094776

  19. SPC-Prep. Instructor's Guide. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This instructor's guide contains materials for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform SPC…

  20. SPC-Prep 1. Participant's Manual. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This companion document to the instructor's guide for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform…

  1. TPG bus passes

    CERN Multimedia

    Staff Association

    2013-01-01

    The CERN Staff Association will stop selling TPG bus passes. All active and retired members of the CERN personnel will be able to purchase Unireso bus passes from the CERN Hostel - Building 39 (Meyrin site) from 1st February 2013. For more information: https://cds.cern.ch/journal/CERNBulletin/2013/04/Announcements/1505279?ln=en

  2. PREP advertisement features affect smokers’ beliefs regarding potential harm

    Science.gov (United States)

    Strasser, Andrew A; Tang, Kathy Z; Tuller, Michael D; Cappella, Joseph N

    2014-01-01

    Background The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. Objective To determine the effect of altering advertisement features on smokers’ beliefs of the harm exposure from a PREP. Methods A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a “red” condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a “no text” condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using “incorrect,” “unsure” and “correct” as outcomes, and advertisement type and covariates as predictors, was used for analyses. Results Participants randomised to the “no text” advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, healthier and make smoking safer. Conclusions Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising. PMID:18768457

  3. Knowledge is Power! Increased Provider Knowledge Scores Regarding Pre-exposure Prophylaxis (PrEP) are Associated with Higher Rates of PrEP Prescription and Future Intent to Prescribe PrEP.

    Science.gov (United States)

    Blumenthal, Jill; Jain, Sonia; Krakower, Douglas; Sun, Xiaoying; Young, Jason; Mayer, Kenneth; Haubrich, Richard

    2015-05-01

    The FDA approval of emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP) in 2012 has raised questions about the delivery of PrEP in a real-world setting. iPad-based questionnaires were given to providers at conferences in California and New York to assess knowledge, experience and attitudes regarding PrEP in HIV and non-HIV providers. HIV provider status was defined either by self-identification or by having greater than 5 years of HIV care experience. Knowledge scores were the sum of correct answers from five PrEP knowledge questions. Univariate analyses used t-test to compare knowledge scores and Fisher's exact test for past or future PrEP prescription between HIV and non-HIV providers. Multivariable linear or logistic regression models were used to assess factors associated with the outcomes. Of 233 respondents, the mean age was 40 years, 59 % were White, 59 % were physicians and 52 % were HIV providers. In univariate analysis, mean PrEP knowledge scores (max 5) were significantly higher for HIV providers (2.8 versus 2.2; p 41 (mean 2.8 versus 2.3; p = 0.004), White race (2.7 versus 2.2; p = 0.026) and participants in the New York region (3.0 versus 2.3; p knowledge scores, all but age remained significant. Among 201 potential prescribers, the rate of prior PrEP prescription was higher among HIV providers than non-HIV providers (34 versus 9 %; p knowledge score, but the association with provider status was no longer significant in multivariable analysis that controlled for knowledge. Intent to prescribe PrEP in the future was high for all provider types (64 %) and was associated with knowledge scores in multivariable analysis. The most common concerns about PrEP (>40 % of providers) were drug toxicities, development of resistance and patient adherence to follow-up; 32 % identified risk compensation as a concern. HIV providers had significantly greater PrEP knowledge than non-HIV providers, but differences by provider type in past PrEP

  4. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    Science.gov (United States)

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  5. Passing and Catching in Rugby.

    Science.gov (United States)

    Namudu, Mike M.

    This booklet contains the fundamentals for rugby at the primary school level. It deals primarily with passing and catching the ball. It contains instructions on (1) holding the ball for passing, (2) passing the ball to the left--standing, (3) passing the ball to the left--running, (4) making a switch pass, (5) the scrum half's normal pass, (6) the…

  6. Passing and Catching in Rugby.

    Science.gov (United States)

    Namudu, Mike M.

    This booklet contains the fundamentals for rugby at the primary school level. It deals primarily with passing and catching the ball. It contains instructions on (1) holding the ball for passing, (2) passing the ball to the left--standing, (3) passing the ball to the left--running, (4) making a switch pass, (5) the scrum half's normal pass, (6) the…

  7. PrEP in Europe – expectations, opportunities and barriers

    Science.gov (United States)

    McCormack, Sheena Mary; Noseda, Veronica; Molina, Jean-Michel

    2016-01-01

    Introduction In contrast to the global trend showing a decline in new HIV infections, the number reported in the World Health Organization (WHO) region of Europe is increasing. Health systems are disparate, but even countries with free access to screening and treatment observe continuing high rates of new infections in key populations, notably men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is only available in France. This commentary describes the European epidemics and healthcare settings where PrEP could be delivered, how need might be estimated for MSM and the residual barriers to access. Discussion Health systems and government commitment to HIV prevention and care, both financial and political, differ considerably between the countries that make up Europe. A common feature is that funds for prevention are a small fraction of funds for care. Although care is generally good, access is limited in the middle-income countries of Eastern Europe and central Asia, and only 19% of people living with HIV received antiretroviral therapy in 2014. It is challenging to motivate governments or civil society to implement PrEP in the context of this unmet treatment need, which is driven by limited national health budgets and diminishing assistance from foreign aid. The high-income countries of Western Europe have hesitated to embrace PrEP for different reasons, initially due to key gaps in the evidence. Now that PrEP has been shown to be highly effective in European MSM in two randomized controlled trials, it is clear that the major barrier is the cost of the drug which is still on patent, although inadequate health systems and diminishing investment in civil society are also key challenges to overcome. Conclusions The momentum to implement PrEP in European countries is increasing and provides a welcome opportunity to expand and improve clinical services and civil society support focused on HIV and related infections including other sexually transmitted and

  8. Instructional and Organizational Effectiveness in Selected PREPS-Identified Value Added and PREPS-Identified Value Subtracted Elementary Schools in Mississippi

    Science.gov (United States)

    Henderson, Jimmy Dale

    2011-01-01

    This study examined the perceptions of principals, teachers, and support staff at 3 PREPS-identified value added and three PREPS-identified value subtracted elementary schools in Mississippi to determine if there were "effective schools" practices in the areas of instructional and organizational systems that were unique to either group. The…

  9. Pass 390 dollari eest

    Index Scriptorium Estoniae

    2003-01-01

    Venekeelne internetilehekülg müüb võltsitud Eesti Vabariigi passe. Kodakondsus- ja migratsiooniameti pressiesindaja Heikki Kirotari ja Piirivalveameti reisidokumentide keskuse ülema kapten Veiko Kulla hinnangud

  10. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Directory of Open Access Journals (Sweden)

    Iryna Zablotska

    2016-10-01

    Full Text Available Introduction: HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM and other key populations. Pre-exposure prophylaxis (PrEP is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion: Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions: Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes.

  11. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Science.gov (United States)

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  12. Time-Dependent Effect of Chlorhexidine Surgical Prep

    Science.gov (United States)

    2011-10-15

    skin prep prior to venous puncture for blood cultures has resulted in a lower false-positive ratewhen compared to non-alcoholic povidoneeiodine.9...vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792e801. 9. Caldeira D, David C, Sampaio C. Skin antiseptics in venous puncture -site...load throughout the entire duration of the study. Regarding skin preparation prior to insertion of central venous pressure catheters, the current

  13. Meaning-making in the industrialized test prep classroom

    OpenAIRE

    2011-01-01

    Evidence for the efficacy of test-mimicking pedagogical practices anchored to "non-controversial topics" - what one researcher has referred to as the "McDonaldisation of English" and another, the "TOEFLizing of teaching" - is scarce. Though complex, the crux of the problem is 'negative washback' (the subordination of teaching to the dictates of the international proficiency assessment market) and 'test score pollution' (inflated prep-induced test results). This paper explores the issue in sev...

  14. Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

    Science.gov (United States)

    2015-10-01

    associated sepsis remains the principal lethal risk associated with platelet transfusion. Cold storage (4°C) is known to reduce post transfusion...and no residual radiation is detectable . *P-selectin samples will be prepped on end of storage day and batch tested. **Bacterial Culture sample...temperature controlled room until such time as they have no detectable residual radiation. This is generally about 3-4 months. At that point they are

  15. Entropy Message Passing Algorithm

    CERN Document Server

    Ilic, Velimir M; Branimir, Todorovic T

    2009-01-01

    Message passing over factor graph can be considered as generalization of many well known algorithms for efficient marginalization of multivariate function. A specific instance of the algorithm is obtained by choosing an appropriate commutative semiring for the range of the function to be marginalized. Some examples are Viterbi algorithm, obtained on max-product semiring and forward-backward algorithm obtained on sum-product semiring. In this paper, Entropy Message Passing algorithm (EMP) is developed. It operates over entropy semiring, previously introduced in automata theory. It is shown how EMP extends the use of message passing over factor graphs to probabilistic model algorithms such as Expectation Maximization algorithm, gradient methods and computation of model entropy, unifying the work of different authors.

  16. Allergic contact dermatitis to gamma-irradiated WEBCOL alcohol prep pads.

    Science.gov (United States)

    Firoz, Elnaz F; Turnbull, Rowena K; Loomis, Cynthia A; Brownell, Isaac

    2013-01-01

    We report a case of allergic contact dermatitis to WEBCOL(®) alcohol prep pads in a healthy 17-year-old girl who showed no reaction to the individual components of the prep pads upon provocative use testing. Although several case reports have described allergic contact dermatitis to isopropyl alcohol, there have been no reports of allergic contact dermatitis to alcohol prep pads sterilized with gamma irradiation, a common sterilization technique capable of producing volatile products in this type of alcohol prep pad.

  17. Lecture to inquiry: The transformation of a tech prep biology teacher

    Science.gov (United States)

    Haskell, Deborah Harris

    As teachers implement the National Science Education Standards (NRC, 1996) many have to reform the instructional methods they have used throughout their careers. This case study examines the transformation of Laurie, a 20-year teacher, during her first year of change from a "traditional" textbook/lecture style of teaching to a facilitator of an inquiry-based classroom. Implementing change requires not only pedagogical expertise, but also the belief that the modifications can be made and that the outcomes are significant. Using Bandura's social cognitive theory as a framework, changes in Laurie's self-efficacy, outcome expectancy, and motivation are followed throughout the transition. During her first year of change, Laurie used worksheets, small group activities, and guided inquiry activities, all strategies in which she had high self-efficacy and experienced positive student outcomes. She rarely used class forums, authentic assessment, and formative assessment. Factors that influenced her change were experiential professional development opportunities that allowed her to practice inquiry-based techniques, a change in her teaching environment from college prep chemistry to tech prep biology, autonomy regarding classroom decisions, and reflective decision making as she learned through experience. Using a standards-based biology textbook increased her self-efficacy toward using inquiry-based practices. The textbook format of embedding text in activities rather than adding activities to the text resulted in an increase of the number and frequency of activities done. Facilitating the textbook's Guided Inquiries and Extended Inquiries helped Laurie gain experience with inquiry-based methods. She also realized that when building from the students' concrete experiences, her students were able to attain higher-level thinking skills. The study revealed six factors contributing to Laurie's change process: (a) experiential professional development, (b) motivation for change

  18. Evaluating the effectiveness of PrepSTART for promoting oral language and emergent literacy skills in disadvantaged preparatory students.

    Science.gov (United States)

    Lennox, Maria; Westerveld, Marleen F; Trembath, David

    2016-09-19

    This study examined the effectiveness of a classroom-based intervention programme aimed at improving the oral language and emergent literacy skills of students from low socio-economic, culturally diverse backgrounds within their first formal year of schooling ("prep"). Data from 137 students were available for analysis. Participants were from three primary schools located in Queensland, Australia. Eight classes were allocated to intervention and two classes acted as a business as usual control. All students received literacy instruction as per the Australian Curriculum. However, the intervention group received 24 weeks of scripted, classroom-based, book-based intervention targeting code- and meaning-related emergent literacy skills. All students were assessed individually pre- and post-intervention on code-related measures (i.e. letter identification and phonological awareness) and meaning-related measures (i.e. vocabulary, oral narrative comprehension and retell). All students made significant improvement over time for all measures. Students in the intervention group showed significantly more progress than the business as usual group on all measures, except for letter identification and oral narrative comprehension. This classroom-based book-based intervention can improve the code- and meaning-related emergent literacy skills of prep students from low socio-economic backgrounds and provide these students with the building blocks for successful literacy acquisition.

  19. Multi-pass microscopy

    Science.gov (United States)

    Juffmann, Thomas; Klopfer, Brannon B.; Frankort, Timmo L. I.; Haslinger, Philipp; Kasevich, Mark A.

    2016-09-01

    Microscopy of biological specimens often requires low light levels to avoid damage. This yields images impaired by shot noise. An improved measurement accuracy at the Heisenberg limit can be achieved exploiting quantum correlations. If sample damage is the limiting resource, an equivalent limit can be reached by passing photons through a specimen multiple times sequentially. Here we use self-imaging cavities and employ a temporal post-selection scheme to present full-field multi-pass polarization and transmission micrographs with variance reductions of 4.4+/-0.8 dB (11.6+/-0.8 dB in a lossless setup) and 4.8+/-0.8 dB, respectively, compared with the single-pass shot-noise limit. If the accuracy is limited by the number of detected probe particles, our measurements show a variance reduction of 25.9+/-0.9 dB. The contrast enhancement capabilities in imaging and in diffraction studies are demonstrated with nanostructured samples and with embryonic kidney 293T cells. This approach to Heisenberg-limited microscopy does not rely on quantum state engineering.

  20. Application of the ThinPrep Imaging System in Urine Cytology A Prospective Study

    NARCIS (Netherlands)

    van Hemel, Bettien M.; Haarsma, Jolanda G.; Ruitenbeek, Teus; Groen, Henk; Suurmeijer, Albert J. H.

    2013-01-01

    BACKGROUND In this prospective study, for the first time, the authors compared the accuracy of reading urine specimens using the ThinPrep Imager System (TIS) with the accuracy of conventional screening for the detection of abnormal urine cells. METHODS ThinPrep slides were made from 1455 urine speci

  1. Charter Schools as Nation Builders: Democracy Prep and Civic Education. Policy Brief 4

    Science.gov (United States)

    Lautzenheiser, Daniel; Kelly, Andrew P.

    2013-01-01

    This policy brief is the first in a series of in-depth case studies exploring how top-performing charter schools have incorporated civic learning in their school curriculum and school culture. This paper introduces Democracy Prep, a network of seven public charter schools with a civic mission at its core. Democracy Prep's founder and…

  2. Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.

    Directory of Open Access Journals (Sweden)

    Kentaro Yoshioka

    Full Text Available Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused late embryonic lethality associated with defective hematopoiesis and angiogenesis. In the present study, we generated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence causes significant hematopoietic abnormalities in the adult bone marrow. Loss of Prep1 promotes cell cycling of hematopoietic stem/progenitor cells (HSPC, leading to the expansion of the HSPC pool. Prep1 deficiency also results in the accumulation of lineage-committed progenitors, increased monocyte/macrophage differentiation and arrested erythroid maturation. Maturation of T cells and B cells is also perturbed in Prep-deficient mice. These findings provide novel insight into the pleiotropic roles of Prep1 in adult hematopoiesis that were unrecognized in previous studies using germline Prep1 hypomorphic mice.

  3. Value passing for Communicating Piecewise Deterministic Markov Processes

    NARCIS (Netherlands)

    Strubbe, Stefan; Schaft, Arjan van der; Julius, Agung

    2006-01-01

    In this paper we extend the CPDP model, which is used for compositional specification of PDP-type stochastic hybrid systems, to the value passing CPDP model. With value passing we can express communication of values of continuous variables between CPDP components. We show that the class of value pas

  4. Logical Consequences: Using Passing Times to Prevent Misbehavior

    Science.gov (United States)

    Harriman, Dion; Pierre, Christina

    2009-01-01

    This article discusses the No Passing Plan, a no-passing policy implemented at White Bear Lake (MN) High School-North Campus in order to prevent chronic tardiness and misbehavior in the halls. The plan is an alternative consequence for administrators to use with students who are disruptive in the halls or consistently tardy to class. Suspending…

  5. Passing the baton

    CERN Multimedia

    2011-01-01

    It was not only in South Korea that batons were being passed last week. While the cream of the world’s athletes were competing in the World Athletics Championships, the cream of the world’s accelerator scientists were on their way to San Sebastian in Spain for the International Particle Accelerator Conference.  One of them was carrying a rather special baton for a handover of a different kind.   When Fermilab’s Vladimir Shiltsev handed the high-energy frontier baton to CERN’s Mike Lamont on Tuesday, it marked the end of an era: a time to look back on the phenomenal contribution the Tevatron has made to particle physics over its 25-year operational lifetime, and the great contribution Fermilab has made over that period to global collaboration in particle physics. There’s always a lot of emotion involved in passing the baton. In athletics, it’s the triumph of wining or the heartbreak of losing. But for this special baton, the...

  6. TRT Barrel milestones passed

    CERN Multimedia

    Ogren, H

    2004-01-01

    The barrel TRT detector passed three significant milestones this spring. The Barrel Support Structure (BSS) was completed and moved to the SR-1 building on February 24th. On March 12th the first module passed the quality assurance testing in Building 154 and was transported to the assembly site in the SR-1 building for barrel assembly. Then on April 21st the final production module that had been scanned at Hampton University was shipped to CERN. TRT Barrel Module Production The production of the full complement of barrel modules (96 plus 9 total spares) is now complete. This has been a five-year effort by Duke University, Hampton University, and Indiana University. Actual construction of the modules in the United States was completed in the first part of 2004. The production crews at each of the sites in the United States have now completed their missions. They are shown in the following pictures. Duke University: Production crew with the final completed module. Indiana University: Module producti...

  7. Education Bill passes

    Science.gov (United States)

    Richman, Barbara T.

    On March 2 the U.S. House of Representatives passed a bill authorizing $425 million for science and mathematics education in fiscal 1984; the authorization is $350 million more than President Ronald Reagan requested in his budget proposal (Eos, February 15, 1983, p. 65).H.R. 1310 allocates $295 million to the Department of Education not only to improve precollege instruction in science and math, but to beef up foreign language training to aid in improving international communication among scientists. The bill also allots $130 million to the National Science Foundation for a variety of programs, the lion's share of which aims to upgrade research equipment at colleges and universities. It is hoped that industry will match the $100 million targeted for this program.

  8. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi

    Science.gov (United States)

    Arnold, Trisha; Brinkley-Rubinstein, Lauren; Chan, Philip A.; Perez-Brumer, Amaya; Bologna, Estefany S.; Beauchamps, Laura; Johnson, Kendra; Mena, Leandro; Nunn, Amy

    2017-01-01

    Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi. Thirty MSM who were prescribed PrEP at an outpatient primary care clinic were interviewed and included 23 men who had been retained in PrEP care and seven who had not been retained. The mean age of participants was 26.6 years. Most (23) participants were African American. Major factors affecting PrEP use and retention in PrEP care included 1) structural factors such as cost and access to financial assistance for medications and clinical services; 2) social factors such as stigma and relationship status; 3) behavioral factors including sexual risk behaviors; and 4) clinical factors such as perceived and actual side effects. Many participants also discussed the positive spillover effects of PrEP use and reported that PrEP had a positive impact on their health. Four of the seven individuals who had not been retained re-enrolled in PrEP care after completing their interviews, suggesting that case management and ongoing outreach can enhance retention in PrEP care. Interventions to enhance retention in PrEP care among MSM in the Deep South will be most effective if they address the complex structural, social, clinical, and behavioral factors that influence PrEP uptake and retention in PrEP care. PMID:28222118

  9. Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

    Science.gov (United States)

    Oriente, Francesco; Fernandez Diaz, Luis Cesar; Miele, Claudia; Iovino, Salvatore; Mori, Silvia; Diaz, Victor Manuel; Troncone, Giancarlo; Cassese, Angela; Formisano, Pietro; Blasi, Francesco; Beguinot, Francesco

    2008-09-01

    We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by skeletal muscle. This muscle phenotype does not depend on reduced expression of the known Prep1 transcription partner, Pbx1. Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160. Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle. Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1. In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype. Finally, we show that Prep1 controls the stability of the p160 protein. We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.

  10. Efficient endotoxin removal with a new sanitizable affinity column: Affi-Prep Polymyxin.

    Science.gov (United States)

    Talmadge, K W; Siebert, C J

    1989-08-04

    A new affinity column packing for removal of endotoxins has been prepared by coupling USP drug-quality polymyxin B to Affi-Prep, a novel synthetic macroporous polymer. Affi-Prep Polymyxin binds endotoxins from a number of different strains of gram-negative bacteria. Endotoxin binding is not significantly affected by 10 mg/ml of bovine serum albumin or human immunoglobulin G, by 1 mg/ml sodium dodecyl sulphate, or by 1 mg/ml deoxycholate. Affi-Prep Polymyxin is stable to treatment with 1.0 M sodium hydroxide, an important property for sanitizing the resin. The resin shows a high ligand stability, since no leakage of polymyxin B from the packing could be detected. Affi-Prep Polymyxin exhibited the highest endotoxin binding efficiency when compared with several commercial agarose affinity packings.

  11. Preliminary investigation of the advertising and availability of PREPs, the new "safe" tobacco products.

    Science.gov (United States)

    Hickman, Norval; Klonoff, Elizabeth A; Landrine, Hope; Kashima, Kennon; Parekh, Bina; Fernandez, Senaida; Thomas, Kamala; Brouillard, Catherine; Zolezzi, Michele; Jensen, Jennifer; Weslowski, Zorahna

    2004-08-01

    The tobacco industry recently introduced a new set of "safe" cigarettes and nicotine delivery devices that purportedly entail reduced tobacco-related disease risk due to their lower level of some carcinogens and toxins. Little is know about the biological impact of these potential reduced exposure products (PREPs) and nothing is known about their advertising and availability. Hence, two pilot studies were conducted to examine the latter issues for the first time. In Study 1, we examined tobacco ads in 10 popular magazines 1998--2002 and found that only 1% of ads were for PREPs. In Study 2, we attempted to purchase PREPs in a random sample of 113 small stores and found that only 4.4% sold any PREP. These preliminary findings tentatively suggest that the industry might not yet be heavily invested in products that have the potential to increase tobacco use by decreasing its perceived harm. Studies with larger samples are recommended.

  12. Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.

    Science.gov (United States)

    Mathiasen, Lisa; Bruckmann, Chiara; Pasqualato, Sebastiano; Blasi, Francesco

    2015-01-01

    Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high instability and insufficient purity, in particular for structural studies. We cloned the cDNA of both proteins into a dicistronic vector containing an N-terminal glutathione S-transferase (GST) tag and co-expressed and co-purified a stable PBX1:PREP1 complex. For structural studies, we produced two C-terminally truncated complexes that retain their ability to bind DNA and are more stable than the full-length proteins through various purification steps. Here we report the production of large amounts of soluble and pure recombinant human PBX1:PREP1 complex in an active form capable of binding DNA.

  13. The world-class Howard's Pass SEDEX Zn-Pb district, Selwyn Basin, Yukon. Part I: trace element compositions of pyrite record input of hydrothermal, diagenetic, and metamorphic fluids to mineralization

    Science.gov (United States)

    Gadd, Michael G.; Layton-Matthews, Daniel; Peter, Jan M.; Paradis, Suzanne J.

    2016-03-01

    The Howard's Pass district, located in Yukon Territory, comprises 14 Zn-Pb sedimentary exhalative (SEDEX) deposits that collectively contain approximately 400.7 Mt grading at 4.5 % Zn and 1.5 % Pb. Sulfide mineralization is hosted in carbonaceous and calcareous to siliceous mudstones. Pyrite is a minor but ubiquitous component. Detailed petrographic analyses reveal that pyrite has a complex and protracted growth history, and multiple generations of pyrite are preserved in single grains. Combined electron probe microanalysis (EPMA) and laser ablation-inductively coupled mass plasma-mass spectrometry (LA-ICP-MS) of paragenetically complex pyrite reveal minor and trace element zonation that mimic textural features. These data provide information on the relative timing and cation content of depositional (i.e., ambient marine), hydrothermal, and metamorphic fluids. These data also identify a suite of nonore elements (Mn, As, Ag, Sb, and Tl) associated with the Zn-Pb mineralizing hydrothermal fluids. Lithogeochemical data and statistical results corroborate the microanalytical findings. These elements are associated with both syngenetic to earliest diagenetic pyrite and later diagenetic pyrite overgrowths, suggesting that SEDEX mineralization was not only the product of hydrothermal precipitates that settled on the seafloor, but also dense metalliferous brine also settled on, and percolated through, unconsolidated carbonaceous muds and precipitated metals. This genetic model is similar to that proposed for the Paleoproterozoic HYC Zn-Pb-Ag SEDEX deposit in northern Australia, and it is likely that common processes and ambient conditions led to the formation and preservation of both of these large SEDEX districts.

  14. Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.

    Science.gov (United States)

    Longobardi, E; Penkov, D; Mateos, D; De Florian, G; Torres, M; Blasi, Francesco

    2014-01-01

    TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction surfaces. Members of the three sets of protein form dimers in which the common partner is PBX but they can also directly interact with other proteins forming higher-order complexes, in particular HOX. Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed. These studies have generated a few general rules that can be applied to all members of the three gene families. PREP and MEIS recognize slightly different consensus sequences: PREP prefers to bind to promoters and to have PBX as a DNA-binding partner; MEIS prefers HOX as partner, and both PREP and MEIS drive PBX to their own binding sites. This outlines the clear individuality of the PREP and MEIS proteins, the former mostly devoted to basic cellular functions, the latter more to developmental functions.

  15. Preferences for HIV pre-exposure prophylaxis (PrEP) information among men-who-have-sex-with-men (MSM) at community outreach settings

    Science.gov (United States)

    Merchant, Roland C.; Corner, David; Garza, Eduardo; Guan, Wentao; Mayer, Kenneth H.; Brown, Larry; Chan, Philip A

    2016-01-01

    Community outreach efforts to increase HIV pre-exposure prophylaxis (PrEP) utilization by at risk men-who-have-sex-with-men (MSM) first need to elucidate preferences for learning about PrEP and linking to PrEP resources. In this pilot study, we observed that among MSM recruited through community outreach, HIV sexual risk-taking was significant, yet self-perceived PrEP knowledge was low and interest in learning more about PrEP was moderate. Most preferred learning about PrEP and being provided local PrEP clinic information through electronic media. However, receipt of PrEP information alone did not appear to motivate these men into presenting to a local clinic for PrEP evaluation. PMID:27076865

  16. Multiple pass laser amplifier system

    Science.gov (United States)

    Brueckner, Keith A.; Jorna, Siebe; Moncur, N. Kent

    1977-01-01

    A laser amplification method for increasing the energy extraction efficiency from laser amplifiers while reducing the energy flux that passes through a flux limited system which includes apparatus for decomposing a linearly polarized light beam into multiple components, passing the components through an amplifier in delayed time sequence and recombining the amplified components into an in phase linearly polarized beam.

  17. Role of the pharmacist in pre-exposure chemoprophylaxis (PrEP) therapy for HIV prevention.

    Science.gov (United States)

    Clauson, Kevin A; Polen, Hyla H; Joseph, Shine A; Zapantis, Antonia

    2009-01-01

    With a global estimate of 2.5 million new infections of HIV occurring yearly, discovering novel methods to help stem the spread of the virus is critical. The use of antiretroviral chemoprophylaxis for preventing HIV after accidental or occupational exposure and in maternal to fetal transmission has become a widely accepted method to combat HIV. Based on this success, pre-exposure chemoprophylaxis (PrEP) is being explored in at-risk patient populations such as injecting drug users, female sex workers and men who have sex with men. This off-label and unmonitored use has created a need for education and intervention by pharmacists and other healthcare professionals. Pharmacists should educate themselves on PrEP and be prepared to counsel patients about their means of obtaining it (e.g. borrowing or sharing medications and ordering from disreputable Internet pharmacies). They should also be proactive about medication therapy management in these patients due to clinically important drug interactions with PrEP medications. Only one trial exploring the safety and efficacy of tenofovir as PrEP has been completed thus far. However, five ongoing trials are in various stages and two additional studies are scheduled for the near future. Unfortunately, studies in this arena have met with many challenges that have threatened to derail progress. Ethical controversy surrounding post-trial care of participants who seroconvert during studies, as well as concerns over emerging viral resistance and logistical site problems, have already halted several PrEP trials. Information about these early trials has already filtered down to affected individuals who are experimenting with this unproven therapy as an "evening before pill". The potential for PrEP is promising; however, more extensive trials are necessary to establish its safety and efficacy. Pharmacists are well-positioned to play a key role in helping patients make choices about PrEP, managing their therapy, and developing policy

  18. WebPASS PP (HR Personnel Management)

    Data.gov (United States)

    US Agency for International Development — WebPass Explorer (WebPASS Framework): USAID is partnering with DoS in the implementation of their WebPass Post Personnel (PS) Module. WebPassPS does not replace...

  19. WebPASS Explorer (HR Personnel Management)

    Data.gov (United States)

    US Agency for International Development — WebPass Explorer (WebPASS Framework): USAID is partnering with DoS in the implementation of their WebPass Post Personnel (PS) Module. WebPassPS does not replace...

  20. Multi-pass spectroscopic ellipsometry

    Energy Technology Data Exchange (ETDEWEB)

    Stehle, Jean-Louis [Sopralab, 7 rue du Moulin des Bruyeres, 92400 Courbevoie (France); Samartzis, Peter C., E-mail: sama@iesl.forth.gr [Institute of Electronic Structure and Laser, Foundation of Research and Technology-Hellas, Vassilika Vouton 71110, Heraklion Crete (Greece); Stamataki, Katerina [Institute of Electronic Structure and Laser, Foundation of Research and Technology-Hellas, Vassilika Vouton 71110, Heraklion Crete (Greece); Department of Chemistry, University of Crete, Voutes, 71003, Heraklion (Greece); Piel, Jean-Philippe [Sopralab, 7 rue du Moulin des Bruyeres, 92400 Courbevoie (France); Katsoprinakis, George E.; Papadakis, Vassilis [Institute of Electronic Structure and Laser, Foundation of Research and Technology-Hellas, Vassilika Vouton 71110, Heraklion Crete (Greece); Schimowski, Xavier [Sopralab, 7 rue du Moulin des Bruyeres, 92400 Courbevoie (France); Rakitzis, T. Peter [Institute of Electronic Structure and Laser, Foundation of Research and Technology-Hellas, Vassilika Vouton 71110, Heraklion Crete (Greece); Department of Physics, University of Crete, Voutes, 71003, Heraklion (Greece); Loppinet, Benoit [Institute of Electronic Structure and Laser, Foundation of Research and Technology-Hellas, Vassilika Vouton 71110, Heraklion Crete (Greece)

    2014-03-31

    Spectroscopic ellipsometry is an established technique, particularly useful for thickness measurements of thin films. It measures polarization rotation after a single reflection of a beam of light on the measured substrate at a given incidence angle. In this paper, we report the development of multi-pass spectroscopic ellipsometry where the light beam reflects multiple times on the sample. We have investigated both theoretically and experimentally the effect of sample reflectivity, number of reflections (passes), angles of incidence and detector dynamic range on ellipsometric observables tanΨ and cosΔ. The multiple pass approach provides increased sensitivity to small changes in Ψ and Δ, opening the way for single measurement determination of optical thickness T, refractive index n and absorption coefficient k of thin films, a significant improvement over the existing techniques. Based on our results, we discuss the strengths, the weaknesses and possible applications of this technique. - Highlights: • We present multi-pass spectroscopic ellipsometry (MPSE), a multi-pass approach to ellipsometry. • Different detectors, samples, angles of incidence and number of passes were tested. • N passes improve polarization ratio sensitivity to the power of N. • N reflections improve phase shift sensitivity by a factor of N. • MPSE can significantly improve thickness measurements in thin films.

  1. Rethinking HIV prevention to prepare for oral PrEP implementation for young African women

    Directory of Open Access Journals (Sweden)

    Connie L Celum

    2015-07-01

    Full Text Available Introduction: HIV incidence remains high among young women in sub-Saharan Africa in spite of scale-up of HIV testing, behavioural interventions, antiretroviral treatment and medical male circumcision. There is a critical need to critique past approaches and learn about the most effective implementation of evidence-based HIV prevention strategies, particularly emerging interventions such as pre-exposure prophylaxis (PrEP. Discussion: Women in sub-Saharan Africa are at increased risk of HIV during adolescence and into their 20s, in part due to contextual factors including gender norms and relationship dynamics, and limited access to reproductive and sexual health services. We reviewed behavioural, behavioural economic and biomedical approaches to HIV prevention for young African women, with a particular focus on the barriers, opportunities and implications for implementing PrEP in this group. Behavioural interventions have had limited impact in part due to not effectively addressing the context, broader sexual norms and expectations, and structural factors that increase risk and vulnerability. Of biomedical HIV prevention strategies that have been tested, daily oral PrEP has the greatest evidence for protection, although adherence was low in two placebo-controlled trials in young African women. Given high efficacy and effectiveness in other populations, demonstration projects of open-label PrEP in young African women are needed to determine the most effective delivery models and whether women at substantial risk are motivated and able to use oral PrEP with sufficient adherence to achieve HIV prevention benefits. Conclusions: Social marketing, adherence support and behavioural economic interventions should be evaluated as part of PrEP demonstration projects among young African women in terms of their effectiveness in increasing demand and optimizing uptake and effective use of PrEP. Lessons learned through evaluations of implementation strategies

  2. PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study.

    Science.gov (United States)

    Cremin, Ide; McKinnon, Lyle; Kimani, Joshua; Cherutich, Peter; Gakii, Gloria; Muriuki, Festus; Kripke, Katharine; Hecht, Robert; Kiragu, Michael; Smith, Jennifer; Hinsley, Wes; Gelmon, Lawrence; Hallett, Timothy B

    2017-05-01

    The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget and to identify the circumstances in which pre-exposure prophylaxis (PrEP) could be used in Nairobi, Kenya. A mathematical model was developed to represent HIV transmission in specific key populations (female sex workers, male sex workers, and men who have sex with men [MSM]) and among the wider population of Nairobi. The scale-up of existing interventions (condom promotion, antiretroviral therapy, and male circumcision) for key populations and the wider population as have occurred in Nairobi is represented. The model includes a detailed representation of a PrEP intervention and is calibrated to prevalence and incidence estimates specific to key populations and the wider population. In the context of a declining epidemic overall but with a large sub-epidemic in MSM and male sex workers, an optimal prevention portfolio for Nairobi should focus on condom promotion for male sex workers and MSM in particular, followed by improved antiretroviral therapy retention, earlier antiretroviral therapy, and male circumcision as the budget allows. PrEP for male sex workers could enter an optimal portfolio at similar levels of spending to when earlier antiretroviral therapy is included; however, PrEP for MSM and female sex workers would be included only at much higher budgets. If PrEP for male sex workers cost as much as US$500, average annual spending on the interventions modelled would need to be less than $3·27 million for PrEP for male sex workers to be excluded from an optimal portfolio. Estimated costs per infection averted when providing PrEP to all female sex workers regardless of their risk of infection, and to high-risk female sex workers only, are $65 160 (95% credible interval [CrI] $43 520-$90 250) and $10 920 (95% CrI $4700

  3. Surveillance indicators for potential reduced exposure products (PREPs: developing survey items to measure awareness

    Directory of Open Access Journals (Sweden)

    McNeill Ann

    2009-10-01

    Full Text Available Abstract Background Over the past decade, tobacco companies have introduced cigarettes and smokeless tobacco products (known as Potential Reduced Exposure Products, PREPs with purportedly lower levels of some toxins than conventional cigarettes and smokeless products. It is essential that public health agencies monitor awareness, interest, use, and perceptions of these products so that their impact on population health can be detected at the earliest stages. Methods This paper reviews and critiques existing strategies for measuring awareness of PREPs from 16 published and unpublished studies. From these measures, we developed new surveillance items and subjected them to two rounds of cognitive testing, a common and accepted method for evaluating questionnaire wording. Results Our review suggests that high levels of awareness of PREPs reported in some studies are likely to be inaccurate. Two likely sources of inaccuracy in awareness measures were identified: 1 the tendency of respondents to misclassify "no additive" and "natural" cigarettes as PREPs and 2 the tendency of respondents to mistakenly report awareness as a result of confusion between PREPs brands and similarly named familiar products, for example, Eclipse chewing gum and Accord automobiles. Conclusion After evaluating new measures with cognitive interviews, we conclude that as of winter 2006, awareness of reduced exposure products among U.S. smokers was likely to be between 1% and 8%, with the higher estimates for some products occurring in test markets. Recommended measurement strategies for future surveys are presented.

  4. Head First PMP A Brain-Friendly Guide to Passing the Project Management Professional Exam

    CERN Document Server

    Stellman, Andrew

    2008-01-01

    Media Reviews "I have been doing project management for over 30 years and am considered a subject matter expert in the PMBOK(r) Guide -Third Edition primarily because I am the Project Manager who led the team that developed this edition. As a consultant I was hired to review and evaluate eight of the top selling PMP Exam Preparation books for their accuracy in following the PMBOK® Guide - Third Edition. I have developed and taught a PMP Exam Prep course for a leading R.E.P., and taught PMP Exam preparation classes for PMI Chapters. I can honestly say that Head First PMP is by far the best P

  5. How To Implement a Tech Prep Program Based on the Rhode Island Model. Tech Prep Associate Degree Program. Technical Programs. Business/Office Administration Programs. Allied Health/Dental Health Programs.

    Science.gov (United States)

    Community Coll. of Rhode Island, Warwick.

    This implementation guide contains information based on experiences that occurred during the development and implementation of the Rhode Island Tech Prep Model. It is intended to assist educators in addressing challenges and obstacles faced by the program early in the planning process. It begins with a rationale for tech prep. Rhode Island…

  6. PREP-kurser for soldater, veteraner og deres partnere - en procesevaluering

    DEFF Research Database (Denmark)

    Pollmann, Jeanette Bonde; Hartmann-Madsen, Anne; Vedtofte, Mia Sadowa

    2016-01-01

    Formålet med procesevalueringen er at evaluere, hvordan implementeringen af initiativet PREP-kurser for soldater, veteraner og deres partnere er forløbet. PREP-kurserne tilbydes gratis i en projektperiode fra 2015-2017 i anerkendelsen af at udsendelser kan påvirke parforholdet og kommunikationen...... at evalueringsprocessen er hensigtsmæssig. Det kan ud fra procesevalueringen konkluderes at PREP for soldater, veteraner og deres partnere er blevet implementeret med succes, men at det bør sikres at rapportens anbefalinger implementeres. Vi anbefaler på baggrund af ovenstående at dette initiativ gøres til et permanent...... tilbud for soldater, veteraner og deres pårørende....

  7. Influence of Processing Parameters on Granularity Distribution of Superalloy Powders during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming CHEN; Benfu HU; Yiwen ZHANG; Huiying LI; Quanmao YU

    2003-01-01

    In order to investigate the influence of processing parameters on the granularity distribution of superalloy powders during the atomization of plasma rotating electrode processing (PREP), in this paper FGH95 superalloy powders is prepared under different processing conditions by PREP and the influence of PREP processing parameters on the granularity distribution of FGH95 superalloy powders is discussed based on fractal geometry theory. The results show that with the increase of rotating velocity of the self-consuming electrode, the fractal dimension of the granularity distribution increases linearly, which results in the increase of the proportion of smaller powders. The change of interval between plasma gun and the self-consuming electrode has a little effect on the granularity distribution, also the fractal dimension of the granularity distribution changed a little correspondingly.

  8. Potential Interventions to Support Adherence to HIV Preexposure Prophylaxis (PrEP): A Systematic Review

    Science.gov (United States)

    Marcus, Julia L.; Buisker, Timothy; Horvath, Tara; Amico, K. Rivet; Fuchs, Jonathan D.; Buchbinder, Susan P.; Grant, Robert M.; Liu, Albert Y.

    2014-01-01

    Objectives Adherence is critical for maximizing the effectiveness of preexposure prophylaxis (PrEP) in preventing HIV infection. Strategies for promoting adherence to HIV treatment, and their potential application to PrEP adherence, have received considerable attention. However, adherence promotion strategies for prevention medications have not been well characterized and may be more applicable to PrEP. We aimed to identify adherence support interventions that have been effective in other prevention fields and could be applied in the HIV prevention context to support pill taking among PrEP users. Methods To identify adherence support interventions that could be evaluated and applied in the PrEP context, we conducted a systematic review across the following prevention fields: hypertension, latent tuberculosis infection, hyperlipidemia, oral contraceptives, osteoporosis, malaria prophylaxis, and post-exposure prophylaxis for HIV infection. We included randomized controlled trials that evaluated the efficacy of interventions to improve adherence to daily oral medications prescribed for primary prevention in healthy individuals or for secondary prevention in asymptomatic individuals. Results Our searches identified 585 studies, of which 48 studies met the eligibility criteria and were included in the review; nine evaluated multiple strategies, yielding 64 separately tested interventions. Interventions with the strongest evidence for improving adherence included complex, resource-intensive interventions, which combined multiple adherence support approaches, and low-cost, low-intensity interventions that provided education or telephone calls for adherence support. Conclusions Our review identified adherence interventions with strong evidence of efficacy across prevention fields and provides recommendations for evaluating these interventions in upcoming PrEP studies. PMID:24580813

  9. Views of policymakers, healthcare workers and NGOs on HIV pre-exposure prophylaxis (PrEP): a multinational qualitative study.

    Science.gov (United States)

    Wheelock, Ana; Eisingerich, Andreas B; Gomez, Gabriela B; Gray, Emily; Dybul, Mark R; Piot, Peter

    2012-01-01

    To examine policymakers and providers' views on pre-exposure prophylaxis (PrEP) and their willingness to support its introduction, to inform policy and practice in this emerging field. Semistructured qualitative interview study. Peru, Ukraine, India, Kenya, Uganda, Botswana and South Africa. 35 policymakers, 35 healthcare workers and 21 non-governmental organisation representatives involved in HIV prevention. Six themes emerged from the data: (1) perceived HIV prevention landscape: prevention initiatives needed to be improved and expanded; (2) PrEP awareness: 50 of 91 participants had heard of PrEP; (3) benefits of PrEP: one component of the combination prevention arsenal that could help prioritise HIV prevention, empower key populations and result in economic gains; (4) challenges of PrEP: regimen complexity, cost and cost-effectiveness, risk compensation, efficacy and effectiveness, stigmatisation and criminalisation, information and training and healthcare system capacity; (5) programmatic considerations: user eligibility, communication strategy, cost, distribution, medication and HIV testing compliance and (6) early versus late implementation: participants were divided as to whether they would support an early introduction of PrEP in their country or would prefer to wait until it has been successfully implemented in other countries, with around half of those we spoke to supporting each option. Very few said they would not support PrEP at all. Despite the multiple challenges identified, there was general willingness to support the introduction of PrEP. Yet, strengthening existing HIV prevention efforts was also deemed necessary. Our results suggest that an effective PrEP programme would be delivered in healthcare facilities and involve non-governmental organisations and the community and consider the needs of mobile populations. Comprehensive information packages and training for users and providers would be critical. The cost of PrEP would be affordable and

  10. Attitudes Towards PrEP and Anticipated Condom Use Among Concordant HIV-Negative and HIV-Discordant Male Couples.

    Science.gov (United States)

    Hoff, Colleen C; Chakravarty, Deepalika; Bircher, Anja E; Campbell, Chadwick K; Grisham, Kirk; Neilands, Torsten B; Wilson, Patrick A; Dworkin, Shari

    2015-07-01

    Since the July 2012 approval by the FDA of emtricitabine/ tenofovir disoproxil fumarate (Truvada) for use as pre-exposure prophylaxis (PrEP) against HIV, its feasibility and acceptability has been under study. HIV-discordant couples are likely targets for PrEP but little is known about how this new prevention tool impacts relationships. We examined, among gay male couples, the acceptability of individual and partner use of PrEP and intentions to use condoms with primary and outside partners in the context of PrEP use. Data are from two independent samples of couples recruited in the San Francisco bay area and New York City-a qualitative one (N=48 couples) between March and November, 2011, and a quantitative one (N=171 couples) between June, 2012 and May, 2013. Data were categorized by couple HIV status and general linear models; chi-square tests of independence were used to examine condom-use intentions with primary and outside partners, by sexual risk profile, and race. Almost half of the HIV-negative couples felt PrEP was a good HIV prevention strategy for themselves and their partner. Over half reported that they would not change their current condom use if they or their partner were taking PrEP. However, approximately 30% of HIV-negative couples reported that they would stop using condoms or use them less with primary and outside partners if they were on PrEP or if their partner was on PrEP. A large percentage of couples view PrEP positively. However, to ensure safety for both partners, future programing must consider those who intend not to use condoms while on PrEP.

  11. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Directory of Open Access Journals (Sweden)

    Jae M Sevelius

    2016-10-01

    Full Text Available Introduction: Globally, transgender (“trans” women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods: Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results: To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions: In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators

  12. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Science.gov (United States)

    Sevelius, Jae M; Deutsch, Madeline B; Grant, Robert

    2016-01-01

    Introduction Globally, transgender (“trans”) women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators to uptake and

  13. Neuberger's double-pass algorithm

    Science.gov (United States)

    Chiu, Ting-Wai; Hsieh, Tung-Han

    2003-12-01

    We analyze Neuberger’s double-pass algorithm for the matrix-vector multiplication R(H)ṡY [where R(H) is (n-1,n)th degree rational polynomial of positive definite operator H], and show that the number of floating-point operations is independent of the degree n, provided that the number of sites is much larger than the number of iterations in the conjugate gradient. This implies that the matrix-vector product (H)-1/2Y≃R(n-1,n)(H)ṡY can be approximated to very high precision with sufficiently large n, without noticeably extra costs. Further, we show that there exists a threshold nT such that the double-pass is faster than the single pass for n>nT, where nT≃12 25 for most platforms.

  14. I Knew I Would Be Safer. Experiences of Kenyan HIV Serodiscordant Couples Soon After Pre-Exposure Prophylaxis (PrEP) Initiation.

    Science.gov (United States)

    Ngure, Kenneth; Heffron, Renee; Curran, Kathyrn; Vusha, Sophie; Ngutu, Mariah; Mugo, Nelly; Celum, Connie; Baeten, Jared M

    2016-02-01

    Pre-exposure prophylaxis (PrEP) for HIV-uninfected persons is highly efficacious for HIV prevention. Understanding how people at risk for HIV will use PrEP is important to inform PrEP scale-up and implementation. We used qualitative methods to gather insights into couples' early experiences with PrEP use within the Partners Demonstration Project, an open-label implementation study evaluating integrated delivery of PrEP and antiretroviral therapy (ART). PrEP is offered to HIV uninfected partners until the HIV-infected partner initiates and sustains ART use (i.e., PrEP as a "bridge" to ART initiation and viral suppression). From August 2013 to March 2014 we conducted 20 in-depth dyadic interviews (n = 40) with heterosexual HIV serodiscordant couples participating at the Thika, Kenya study site, exploring how couples make decisions about using PrEP for HIV prevention. We developed and applied deductive and inductive codes to identify key themes related to experiences of PrEP initiation and use of time-limited PrEP. Couples reported that PrEP offered them an additional strategy to reduce the risk of HIV transmission, meet their fertility desires, and cope with HIV serodiscordance. Remaining HIV negative at follow-up visits reinforced couples' decisions and motivated continued adherence to PrEP. In addition, confidence in their provider's advice and client-friendly services were critical to their decisions to initiate and continue use of PrEP. Strategies for wide-scale PrEP delivery for HIV serodiscordant couples in low resource settings may include building capacity of health providers to counsel on PrEP adoption while addressing couples' concerns and barriers to adoption and continued use.

  15. Multiple-pass water reuse

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharyya, D.; Farthing, S.S.; Cheng, C.S.

    1982-02-01

    Low-pressure membranes have definite advantages for the treatment of metal-processing wastewaters and acid mine water. The membrane processes are evaluated in terms of obtaining maximum water recovery (greater than 90%), proper ultrafiltrate quality, multiple-pass water reuse, and concentrate recycle. Various multi-salt solutions containing heavy metals (including cyanide complexes), and acid mine waters have been extensively investigated with a bench-scale unit, and a computer simulation model has been used to scale-up from the laboratory data. Water reuse models are presented for multiple passes. 9 references, 12 figures, 3 tables. (JMT)

  16. The promise and peril of pre-exposure prophylaxis (PrEP): using social science to inform prep interventions among female sex workers.

    Science.gov (United States)

    Syvertsen, Jennifer L; Robertson Bazzi, Angela M; Scheibe, Andrew; Adebajo, Sylvia; Strathdee, Steffanie A; Wechsberg, Wendee M

    2014-09-01

    Advances in biomedical interventions to prevent HIV offer great promise in reducing the number of new infections across sub- Saharan Africa, particularly among vulnerable populations such as female sex workers. Several recent trials testing pre-exposure prophylaxis (PrEP) have demonstrated efficacy, although others have been stopped early for futility. Given the importance and complexities of social and behavioural factors that influence biomedical approaches to prevention, we discuss several key areas of consideration moving forward, including trial participation, adherence strategies, social relationships, and the structural factors that shape PrEP interest, use, and potential effectiveness among female sex workers in sub-Saharan Africa. Our review highlights the importance of involving social scientists in clinical and community-based research on PrEP. We advocate for a shift away from a singular "re-medicalization" of the HIV epidemic to that of a "reintegration" of interdisciplinary approaches to prevention that could benefit female sex workers and other key populations at risk of acquiring HIV.

  17. Feasibility study: PASS computer environment

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-03-10

    The Policy Analysis Screening System (PASS) is a computerized information-retrieval system designed to provide analysts in the Department of Energy, Assistant Secretary for Environment, Office of Technology Impacts (DOE-ASEV-OTI) with automated access to articles, computer simulation outputs, energy-environmental statistics, and graphics. Although it is essential that PASS respond quickly to user queries, problems at the computer facility where it was originally installed seriously slowed PASS's operations. Users attempting to access the computer by telephone repeatedly encountered busy signals and, once logged on, experienced unsatisfactory delays in response to commands. Many of the problems stemmed from the system's facility manager having brought another large user onto the system shortly after PASS was implemented, thereby significantly oversubscribing the facility. Although in March 1980 Energy Information Administration (EIA) transferred operations to its own computer facility, OTI has expressed concern that any improvement in computer access time and response time may not be sufficient or permanent. Consequently, a study was undertaken to assess the current status of the system, to identify alternative computer environments, and to evaluate the feasibility of each alternative in terms of its cost and its ability to alleviate current problems.

  18. Summer Professional Development in Chemistry for Inservice Teachers Using OWL Quick Prep

    Science.gov (United States)

    Powell, Cynthia B.; Pamplin, Kim L.; Blake, Robert E.; Mason, Diana S.

    2010-01-01

    Secondary teachers participating in summer professional development chemistry workshops in Texas used an online chemistry tutoring program, OWL Quick Prep (Day et al. in OWL: Online Web-based Learning, Brooks-Cole Cengage Learning, Florence, KY, 1997) as a part of the inservice training. Self-reported demographic data were used to identify factors…

  19. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  20. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  1. High Schools that Work and Tech Prep: Improving Student Performance in Basic Skills.

    Science.gov (United States)

    Flowers, Jim

    2000-01-01

    Test results for 244 agricultural education students in High Schools that Work (HSTW) sites in North Carolina indicated that, compared to all students at HSTW sites and to college-prep students, they failed to meet HSTW goals in math, reading, and science but were making progress. Their math and science performance was higher than other vocational…

  2. Quality improvement: single-field sterile scrub, prep, and dwell for laparoscopic hysterectomy.

    Science.gov (United States)

    O'Hanlan, Katherine A; McCutcheon, Stacey Paris; McCutcheon, John G; Charvonia, Beth E

    2013-05-01

    The vulva and vaginal interior are considered a contaminated surgical area, and current OR guidelines require surgeons who are gloved and gowned at the abdominal field to avoid contact with the urethral catheter, the uterine manipulator, and the introitus or to change their gloves and even regown if contact occurs. It is our belief that the perception of the vaginal field as contaminated reflects a lack of specific standards for the preoperative cleansing of the deeper vagina and a lack of preoperative prep instructions for the combined fields. We developed a comprehensive single-field prep technique designed to improve surgical efficiency and prevent contamination of the sterile field. Combining a methodical scrub, prep, and dwell, this technique allows the entire abdomino-perineovaginal field to be treated as a single sterile field for laparoscopic procedures. Our surgical site infection rate of 1.8% when using this single-field prep technique and the subsequent surgical treatment of the abdominal, vaginal, and perineal fields as a single sterile field is well within reported norms.

  3. Moving beyond Test-Prep Pedagogy: Dialoguing with Multicultural Preservice Teachers for a Quality Education

    Science.gov (United States)

    Rodríguez, Louie F.

    2013-01-01

    In a "post-NCLB era," the schooling experiences of mostly low-income students of color continue to be consumed by a test-prep pedagogy--narrowed curriculum, low expectations, and ignored relationships. In this article the author describes a pedagogical approach using educational dialogues to engage preservice teachers to critically…

  4. Restructuring Student Experiences Using Tech Prep Mapping To Integrate Vocational and Academic Curriculum.

    Science.gov (United States)

    Pirozzoli, Don

    The growing emphasis on accountability and the demand for better prepared students is pressing institutions of higher education to examine restructuring. Student experiences represent an important arena for school restructuring, and a useful approach to changing student experiences is the Tech Prep Mapping (TPM) process. The TPM process requires…

  5. An Investigation of Craniocervical Posture in Class II & Class III Skeletal Patients

    Directory of Open Access Journals (Sweden)

    T. HoseinZadeh-Nik

    2005-02-01

    Full Text Available Statement of Problem: Craniocervical Posture is a factor in the development and function of Craniofacial Structure. Previous studies of different samples have demonstrated associations between craniocervical posture and craniofacial morphology.Purpose: This study aimed lo examine whether any significant association is evident or not between craniocervical posture and the occurrence of Class il & Class III skeletal malocclusions.Materials and Methods: A sample of 76 subjects with Class II & Class III skeletal malocclusion aged 9-i 1 and>18 years were selected. None of them had received orthodontic treatment. Lateral cephalometric radiographs were taken in natural head position (NHP, and craniocervical and craniohorizental angels were traced and determined for analysis of craniocervical posture. Results: According to the craniocervical posture, most class II skeletal patients have flexed heads and class MI skeletal patients have extended heads, as a result malocclusion in these patients seems to become more severe. With increase in age. class II skeletal patients have more flexed their heads and malocclusion become more severe, while with increase in age in class ill skeletal patients, their heads become extended and once again malocclusion thought lo be more severe. In class II skeletal patients, craniocervical posture has a significant correlation with the vertical growth pattern, but shows little correlation with the horizontal growth pattern. In class 111 skeletal patients, craniocervical posture shows no correlation to any of the vertical & horizontal growth patterns, of course the mean of vertical angles is less in these patients and probably in order to make these relation significant in Class III skeletal patients there is need for more samples, in class II & class III skeletal patients, the amount of Na.prep-point A and pog-Na.prep with craniocervical posture shows a significant correlation. Conclusion: Consideration of craniocervical

  6. Using L1 to Enhance the Grammar Learning and Having Only English Policy in EFL Classes

    Science.gov (United States)

    Uyar, Yusuf

    2012-01-01

    The purpose of this study is to determine the differences of grammar learning, if any, between the EFL classes in which native language (L1) is sometimes used and only target language (L2) is used. Participants were 42 prep year students from one of the universities in Turkey. They have been studying English for 9 months, and now they are in level…

  7. Message-Passing Estimation from Quantized Samples

    CERN Document Server

    Kamilov, Ulugbek; Rangan, Sundeep

    2011-01-01

    Estimation of a vector from quantized linear measurements is a common problem for which simple linear techniques are suboptimal -- sometimes greatly so. This paper develops generalized approximate message passing (GAMP) algorithms for minimum mean-squared error estimation of a random vector from quantized linear measurements, notably allowing the linear expansion to be overcomplete or undercomplete and the scalar quantization to be regular or non-regular. GAMP is a recently-developed class of algorithms that uses Gaussian approximations in belief propagation and allows arbitrary separable input and output channels. Scalar quantization of measurements is incorporated into the output channel formalism, leading to the first tractable and effective method for high-dimensional estimation problems involving non-regular scalar quantization. Non-regular quantization is empirically demonstrated to greatly improve rate--distortion performance in some problems with oversampling or with undersampling combined with a spar...

  8. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users.

    Science.gov (United States)

    Shrestha, Roman; Karki, Pramila; Altice, Frederick L; Dubov, Oleksandr; Fraenkel, Liana; Huedo-Medina, Tania; Copenhaver, Michael

    2017-07-10

    Although people who use drugs (PWUD) are one of the key risk populations who could benefit from the use of pre-exposure prophylaxis (PrEP), to date, little attention has been given to incorporating PrEP into HIV prevention approaches targeting this underserved group. This study investigated the acceptability of PrEP based on a number of known PrEP attributes among high-risk PWUD in a drug treatment setting. A total of 400 HIV-negative PWUD, who reported drug- and/or sex-related risk behaviors were recruited from a methadone clinic to complete a stated preference (full-profile conjoint) survey. Participants ranked the eight hypothetical PrEP program scenarios with varied combinations of six attributes related to PrEP (cost, dosing, efficacy, side-effects, treatment setting, and frequency of HIV testing). SPSS conjoint procedure was used to estimate the relative importance of each attribute and preferences across eight possible PrEP delivery programs. PrEP acceptability ranged from 30.6 to 86.3% with a mean acceptability of 56.2% across the eight hypothetical PrEP program scenarios. The PrEP program scenario with the highest acceptability had the following attribute levels: insurance covered, daily dosing, 95% effective, no side-effects, treatment at HIV clinic, and HIV testing needed every 6 months. The cost associated with PrEP was the most important attribute (relative importance score: RIS = 38.8), followed by efficacy (RIS = 20.5) and side effects (RIS = 11.9); other attributes had no significant effect. Our findings reported a high acceptability of PrEP in response to different PrEP program scenarios with different attribute profiles. As the result of having this information, researchers and policymakers will be better equipped for evidence informed targeting and dissemination efforts to optimize PrEP uptake among this underserved population.

  9. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Science.gov (United States)

    Ravasi, Giovanni; Grinsztejn, Beatriz; Baruch, Ricardo; Guanira, Juan Vicente; Luque, Ricardo; Cáceres, Carlos F; Ghidinelli, Massimo

    2016-01-01

    Introduction Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP) is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint negotiation and

  10. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Directory of Open Access Journals (Sweden)

    Giovanni Ravasi

    2016-10-01

    Full Text Available Introduction: Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion: Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint

  11. Supercomputing "Grid" passes latest test

    CERN Multimedia

    Dumé, Belle

    2005-01-01

    When the Large Hadron Collider (LHC) comes online at the CERN in 2007, it will produce more data than any other experiment in the history of physics. Particle physicists have now passed another milestone in their preparations for the LHC by sustaining a continuous flow of 600 megabytes of dat per second (MB/s) for 10 days from the Geneva laboratory to seven sites in Europe and the US (1/2 page)

  12. 27 CFR 9.88 - Pacheco Pass.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Pacheco Pass. 9.88 Section... Pass. (a) Name. The name of the viticultural area described in this section is “Pacheco Pass.” (b) Approved maps. The appropriate maps for determining the boundaries of Pacheco Pass viticultural area...

  13. Tailored combination prevention packages and PrEP for young key populations

    Directory of Open Access Journals (Sweden)

    Audrey Pettifor

    2015-02-01

    Full Text Available Introduction: Young key populations, defined in this article as men who have sex with men, transgender persons, people who sell sex and people who inject drugs, are at particularly high risk for HIV. Due to the often marginalized and sometimes criminalized status of young people who identify as members of key populations, there is a need for HIV prevention packages that account for the unique and challenging circumstances they face. Pre-exposure prophylaxis (PrEP is likely to become an important element of combination prevention for many young key populations. Objective: In this paper, we discuss important challenges to HIV prevention among young key populations, identify key components of a tailored combination prevention package for this population and examine the role of PrEP in these prevention packages. Methods: We conducted a comprehensive review of the evidence to date on prevention strategies, challenges to prevention and combination prevention packages for young key populations. We focused specifically on the role of PrEP in these prevention packages and on young people under the age of 24, and 18 in particular. Results and discussion: Combination prevention packages that include effective, acceptable and scalable behavioural, structural and biologic interventions are needed for all key populations to prevent new HIV infections. Interventions in these packages should meaningfully involve beneficiaries in the design and implementation of the intervention, and take into account the context in which the intervention is being delivered to thoughtfully address issues of stigma and discrimination. These interventions will likely be most effective if implemented in conjunction with strategies to facilitate an enabling environment, including increasing access to HIV testing and health services for PrEP and other prevention strategies, decriminalizing key populations’ practices, increasing access to prevention and care, reducing stigma and

  14. PreP+07: improvements of a user friendly tool to preprocess and analyse microarray data

    Directory of Open Access Journals (Sweden)

    Claros M Gonzalo

    2009-01-01

    Full Text Available Abstract Background Nowadays, microarray gene expression analysis is a widely used technology that scientists handle but whose final interpretation usually requires the participation of a specialist. The need for this participation is due to the requirement of some background in statistics that most users lack or have a very vague notion of. Moreover, programming skills could also be essential to analyse these data. An interactive, easy to use application seems therefore necessary to help researchers to extract full information from data and analyse them in a simple, powerful and confident way. Results PreP+07 is a standalone Windows XP application that presents a friendly interface for spot filtration, inter- and intra-slide normalization, duplicate resolution, dye-swapping, error removal and statistical analyses. Additionally, it contains two unique implementation of the procedures – double scan and Supervised Lowess-, a complete set of graphical representations – MA plot, RG plot, QQ plot, PP plot, PN plot – and can deal with many data formats, such as tabulated text, GenePix GPR and ArrayPRO. PreP+07 performance has been compared with the equivalent functions in Bioconductor using a tomato chip with 13056 spots. The number of differentially expressed genes considering p-values coming from the PreP+07 and Bioconductor Limma packages were statistically identical when the data set was only normalized; however, a slight variability was appreciated when the data was both normalized and scaled. Conclusion PreP+07 implementation provides a high degree of freedom in selecting and organizing a small set of widely used data processing protocols, and can handle many data formats. Its reliability has been proven so that a laboratory researcher can afford a statistical pre-processing of his/her microarray results and obtain a list of differentially expressed genes using PreP+07 without any programming skills. All of this gives support to scientists

  15. Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.

    Science.gov (United States)

    Risolino, Maurizio; Mandia, Nadia; Iavarone, Francescopaolo; Dardaei, Leila; Longobardi, Elena; Fernandez, Serena; Talotta, Francesco; Bianchi, Fabrizio; Pisati, Federica; Spaggiari, Lorenzo; Harter, Patrick N; Mittelbronn, Michel; Schulte, Dorothea; Incoronato, Mariarosaria; Di Fiore, Pier Paolo; Blasi, Francesco; Verde, Pasquale

    2014-09-01

    Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis. Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplastic transformation by competing with myeloid ecotropic integration site 1 for binding to the common heterodimeric partner Pbx1. Epithelial-mesenchymal transition (EMT) is controlled by complex networks of proinvasive transcription factors responsive to paracrine factors such as TGF-β. Here we show that, in addition to inhibiting primary tumor growth, PREP1 is a novel EMT inducer and prometastatic transcription factor. In human non-small cell lung cancer (NSCLC) cells, PREP1 overexpression is sufficient to trigger EMT, whereas PREP1 down-regulation inhibits the induction of EMT in response to TGF-β. PREP1 modulates the cellular sensitivity to TGF-β by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation through mechanisms dependent, at least in part, on PREP1-mediated transactivation of a regulatory element in the SMAD3 first intron. Along with the stabilization and accumulation of PBX1, PREP1 induces the expression of multiple activator protein 1 components including the proinvasive Fos-related antigen 1 (FRA-1) oncoprotein. Both FRA-1 and PBX1 are required for the mesenchymal changes triggered by PREP1 in lung tumor cells. Finally, we show that the PREP1-induced mesenchymal transformation correlates with significantly increased lung colonization by cells overexpressing PREP1. Accordingly, we have detected PREP1 accumulation in a large number of human brain metastases of various solid tumors, including NSCLC. These findings point to a novel role of the PREP1 homeoprotein in the control of the TGF-β pathway, EMT, and metastasis in NSCLC.

  16. "Support Your Client at the Space That They're in": HIV Pre-Exposure Prophylaxis (PrEP) Prescribers' Perspectives on PrEP-Related Risk Compensation.

    Science.gov (United States)

    Calabrese, Sarah K; Magnus, Manya; Mayer, Kenneth H; Krakower, Douglas S; Eldahan, Adam I; Hawkins, Lauren A Gaston; Underhill, Kristen; Hansen, Nathan B; Kershaw, Trace S; Betancourt, Joseph R; Dovidio, John F

    2017-04-01

    Despite the demonstrated effectiveness of HIV pre-exposure prophylaxis (PrEP) and evidence that most PrEP users do not engage in risk compensation (i.e., increased risk behavior due to a perceived decrease in HIV susceptibility), some healthcare providers report patient risk compensation to be a deterrent to prescribing PrEP. Overcoming this barrier is essential to supporting PrEP access and uptake among people at risk for HIV. To inform such efforts, this qualitative study explored PrEP-related risk compensation attitudes among providers with firsthand experience prescribing PrEP. US-based PrEP providers (n = 18), most of whom were HIV specialists, were recruited through direct outreach and referral from colleagues and other participants. Individual 90-min semistructured interviews were conducted by phone or in person from September 2014 through February 2015, transcribed, and thematically analyzed. Three attitudinal themes emerged: (1) providers' role is to support patients in making informed decisions, (2) risk behavior while taking PrEP does not fully offset PrEP's protective benefit (i.e., PrEP confers net protection, even with added behavioral risk), and (3) PrEP-related risk compensation is unduly stigmatized within and beyond the healthcare community. Participants were critical of other healthcare providers' negative judgment of patients and reluctance to prescribe PrEP due to anticipated risk compensation. Several providers also acknowledged an evolution in their thinking from initial ambivalence toward greater acceptance of PrEP and PrEP-related behavior change. PrEP providers' insights about risk compensation may help to address unsubstantiated concerns about PrEP-related risk compensation and challenge the acceptability of withholding PrEP on these grounds.

  17. Are we PREPared? Quality of information available to patients in the UK about PREP on the internet

    Directory of Open Access Journals (Sweden)

    S Duncan

    2012-11-01

    Full Text Available Professional bodies in the UK (BASHH/BHIVA do not currently recommended pre-exposure prophylaxis (PREP to prevent HIV aquisition for men who have sex with men (MSM [1]. Conversely, although Federal Drug Administration approval is awaited, the Centers for Disease Control (CDC have issued clinicians in the USA with interim guidance to facilitate PREP prescriptions [2]. Increasingly patients search the internet for information on HIV treatment, but disparate international policy can lead to confusing patient messages. This study was conducted to systematically assess the quality of internet information available to patients in the UK about PREP. More than 90% of internet searches in the UK are performed using ‘Google.co.uk’ and ‘Bing’ [3]. Using pre-specified criteria, we reviewed the first 100 hits retrieved from each search engine when the following searches were performed: [“HIV pre-exposure prophylaxis”]; [“HIV PREP”]; [“HIV PREP guidelines”]; [“HIV PREP guidelines UK”]; [“truvada prophylaxis HIV”]. Of 172 unique websites identified, 124 websites were active at the time of the review (July 2012. 33 websites were links to academic journals including commentaries and clinical trials, not intended to specifically provide patient information; 5 were internet portals directing users to alternative sites and 10 websites contained no information about PREP. Of the remaining 76 websites, 28 were written by medical professionals and 48 were written by journalists, where 7/48 (15% were individual blogs. 64/76 (84% contained a definition of PREP; 63/76 (83% discussed the rationale and 58/76 (76% reported efficacy data. Advantages and disadvantages of PREP were presented in 56/76 (74% and 41/76 (54% of websites respectively. Only 21/76 (28% of sites referenced existing national guidelines (CDC/BASHH. A minority of sites described the current clinical practice in the UK (7/76, 9% with an even smaller number presenting the

  18. Are Thai MSM willing to take PrEP for HIV prevention? An analysis of attitudes, preferences and acceptance.

    Directory of Open Access Journals (Sweden)

    Ana Wheelock

    Full Text Available OBJECTIVE: We aimed to understand the attitudes, preferences and acceptance of oral and parenteral PrEP among men who have sex with men (MSM in Thailand. BACKGROUND: Pre-exposure prophylaxis (PrEP, the use of antiretrovirals to prevent HIV acquisition, has shown promising results in recent trials. To assess the potential impact of this new HIV prevention method, in addition to efficacy data, we need to understand which psychosocial factors are likely to determine its uptake among members of potential user groups. METHODS AND FINDINGS: Surveys of willingness to use PrEP products were administered to MSM. Spearman's rank tests were used to uncover associations between questionnaire items. Mann-Whitney tests were performed to ascertain differences between groups. Conjoint analysis was used to examine the attitudes and preferences of MSM towards PrEP attributes. Most participants were willing to consider taking PrEP (39.2% "yes, definitely" and 49.2% "yes, probably" and perceived PrEP as giving them new possibilities in their lives (38.5% "a lot of hope" and 55.8% "some hope", even after being instructed of potential side effects and costs. HIV testing was considered the most important attribute and a daily pill and longer lasting injection in the arm were the preferred routes of administration. CONCLUSIONS: Despite its multiple challenges, MSM in Thailand would be willing to take PrEP, even if they had to experience inconvenience and expense. If PrEP were to be implemented in Thailand, our findings show that its uptake could be considerable.

  19. PREPARATIVE ISOLATION AND PURIFICATION OF CHEMICAL CONSTITUENTS OF BELAMCANDA BY MPLC, HSCCC AND PREP-HPLC

    Science.gov (United States)

    Wang, Xiaohong; Liang, Yong; Peng, Cuilin; Xie, Huichun; Pan, Man; Zhang, Tianyou; Ito, Yoichiro

    2010-01-01

    Combined with medium-pressure liquid chromatography (MPLC) and preparative high-pressure liquid chromatography (Prep-HPLC), high-speed countercurrent chromatography (HSCCC) was successfully applied for separation and purification of isoflavonoids from the extract of belamcanda. HSCCC separation was performed on a two-phase solvent system composed of methyl tert-butyl ether -ethyl acetate - n-butyl alcohol – acetonitrile −0.1% aqueous trifluoroacetic acid at a volume radio of 1:2:1:1:5. Semi-purified peak fractions from HSCCC separation were further purified by Prep-HPLC. Nine well-separated fractions were analyzed by HPLC-UV absorption spectrometry to determine their purities and characterized with ESI-MSn. Except for peaksland VII (unknown) seven compounds were identified as apocynin (peak II), mangiferin (peak III), 7-O-methylmangiferin (peak IV), hispidulin (peak V), 3′-hydroxyltectoridin (peak VI), iristectorin B (peak VII), isoiridin (peak IX). PMID:21552369

  20. Swords, Shields, and the Fight for Our Children: Lessons from Urban Prep

    Science.gov (United States)

    King, Tim

    2011-01-01

    The grim statistics are well known, but bear repeating: in Chicago, close to 60% of Black boys do not graduate from high school, and only one in forty receive a bachelor's degree by age 25. In the fall of 2006, Urban Prep Charter Academy for Young Men-Englewood Campus, the nation's first all-male charter public high school, was opened. In 2010 and…

  1. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    OpenAIRE

    Arcelino Farias-Neto; Edna Maria da Cunha Ferreira Gomes; Alfonso Sánchez-Ayala; Alejandro Sánchez-Ayala; Larissa Soares Reis Vilanova

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents e...

  2. 78 FR 62344 - Sabine Pass Liquefaction Expansion, LLC, Sabine Pass Liquefaction, LLC, and Sabine Pass LNG, L.P...

    Science.gov (United States)

    2013-10-18

    ... Sabine Pass LNG, L.P., Cheniere Creole Trail Pipeline, L.P.; Notice of Application Take notice that on... LNG, L.P. (collectively referred to as Sabine Pass) filed with the Federal Energy Regulatory..., construct, and operate additional liquefied natural gas (LNG) export facilities at the Sabine Pass...

  3. Vehicle dynamic effects in the course of passing over turnouts

    Directory of Open Access Journals (Sweden)

    Zelenka J.

    2007-11-01

    Full Text Available For the quantification of vehicle dynamic effects at passing over turnouts at a higher speed there was developed a methodology for evaluating of acceleration measured on vehicle axle boxes in the year 2003. The methodology is based on statistical evaluation of lateral and vertical acceleration measured values at passing over both critical parts of a turnout (tongue, frog. The created methodology was used for investigation of vehicle dynamic effects by running at speed up to 230 km/h in the year 2004 in terms of high speed tests of tilting-body unit class 680 CD. There was found relatively high values of dynamic effects already at a speed 160 km/h. In terms of tilting-body unit class 680 tests at a higher speed in curves of chosen track lines of 1st and 2nd corridor of Czech Railways there was carried out also verification of curved turnouts state according to methodology mentioned above with a view to possibility of speed increasing at curved throats of chosen stations. Lateral vehicle dynamic effects at passing over a curved turnout frog area were evaluated. There were carried out simulation calculations of vehicle passing over a turnout based on measured geometric parameters of wheelset as well as chosen turnouts. Results of the calculations were compared with measurements. The increased vehicle dynamic effects found in pulsed beats character influence negatively the turnouts part (not only wheel contacting parts as well as operating life all unsuspended parts of vehicles.

  4. Secrecy, empowerment and protection: positioning PrEP in KwaZulu-Natal, South Africa.

    Science.gov (United States)

    Govender, Eliza; Mansoor, Leila; MacQueen, Kate; Abdool Karim, Quarraisha

    2017-11-01

    The release of World Health Organisation guidelines recommending the prophylactic use of daily Truvada(®) for all populations at high risk of acquiring HIV opens the way for implementation of oral pre-exposure prophylaxis (PrEP). The impact of new prevention technologies is, however, dependent on demand creation strategies such as user awareness, acceptability and access, which in turn are influenced by sociocultural and gender norms. This study was conducted in three locations in KwaZulu-Natal, urban, rural and peri-urban, with six participatory workshops. Knowledge, desirable features of a product and demand positioning for PrEP were assessed using a participatory action media research process which included art-based activities and group discussion using a semi-structured interview schedule. The data were analysed using thematic analysis. The key themes that emerged in relation to product adoption were: ability to maintain secrecy of product use; the need for agency with personal choices around HIV prevention; and an increased desire for HIV protection. Findings reaffirm the influence of user engagement in understanding the sociocultural dynamics that influence demand creation for PrEP adoption.

  5. No association between the PREP gene and lithium responsive bipolar disorder

    Directory of Open Access Journals (Sweden)

    Grof Paul

    2007-02-01

    Full Text Available Abstract Background Bipolar disorder (BD is a major psychiatric condition that commonly requires prophylactic and episodic treatment. Lithium (Li has been used for over 40 years now as an effective prophylactic agent. Response to Li treatment seems to be, at least in part, genetically determined. Although we ignore how Li specifically prevents mood episodes, it has previously been suggested that Li exerts an effect on the phosphoinositide pathway, and more recently, it has been proposed that Li may modulate prolyl endopeptidase (PREP. Methods In this study we carried out an association study looking at the PREP gene, located on ch 6q22. Five intronic single nucleotide polymorphisms (SNP, three coding SNPs and one SNP in the 5' UTR were investigated for their frequency in a BD sample of 180 excellent Li responders, 69 Li nonresponders and 126 controls. Genotyping was carried out using the SNaPshot reaction from Applied Biosystems, which is a modified fluorescent single base pair extension procedure. Results Following correction for multiple testing, no significant genotypic, allelic or estimated haplotypic differences were found between responders and nonresponders or between BD patients and controls. Conclusion PREP is an interesting candidate gene to investigate in genetic studies of BD, but our findings do not support the hypothesis that genetic variation in this gene plays a major role in the etiology of BD or Li response.

  6. WebPASS ICASS (HR Personnel Management)

    Data.gov (United States)

    US Agency for International Development — WebPASS Joint Administrative Support Platforms Post Administrative Software Suite - U.S. Department of State Executive Officers application suite. Web.PASS is the...

  7. When you pass your due date

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000515.htm When you pass your due date To use the sharing features ... link between you and your baby. As you pass your due date, the placenta may not work ...

  8. Senate passes clean air bill

    Science.gov (United States)

    In an 89 to 11 vote the Senate passed a clean air bill aimed at reducing pollution by the turn of the century by imposing tougher controls on American industry. The bill is the first revision of the Clean Air Act of 1970 in 13 years and calls for new limits on auto pollution to clean up smog in most U.S. cities, decreasing by half emissions by power plants that cause acid rain to protect the ecology, and increasing technological controls on factories to protect against cancer-causing and toxic substances. The bill will add about $20 billion per year to the estimated $33 billion cost of complying with current pollution laws.

  9. A Latent Class Analysis of Risk Factors for Acquiring HIV Among Men Who Have Sex with Men: Implications for Implementing Pre-Exposure Prophylaxis Programs.

    Science.gov (United States)

    Chan, Philip A; Rose, Jennifer; Maher, Justine; Benben, Stacey; Pfeiffer, Kristen; Almonte, Alexi; Poceta, Joanna; Oldenburg, Catherine E; Parker, Sharon; Marshall, Brandon Dl; Lally, Mickey; Mayer, Kenneth; Mena, Leandro; Patel, Rupa; Nunn, Amy S

    2015-11-01

    Current Centers for Disease Control and Prevention (CDC) guidelines for prescribing pre-exposure prophylaxis (PrEP) to prevent HIV transmission are broad. In order to better characterize groups who may benefit most from PrEP, we reviewed demographics, behaviors, and clinical outcomes for individuals presenting to a publicly-funded sexually transmitted diseases (STD) clinic in Providence, Rhode Island, from 2012 to 2014. Latent class analysis (LCA) was used to identify subgroups of men who have sex with men (MSM) at highest risk for contracting HIV. A total of 1723 individuals presented for testing (75% male; 31% MSM). MSM were more likely to test HIV positive than heterosexual men or women. Among 538 MSM, we identified four latent classes. Class 1 had the highest rates of incarceration (33%), forced sex (24%), but had no HIV infections. Class 2 had 10 anal sex partners in the previous 12 months (69%), anonymous partners (100%), drug/alcohol use during sex (76%), and prior STDs (40%). Class 4 had similar characteristics and HIV prevalence as Class 2. In this population, MSM who may benefit most from PrEP include those who have >10 sexual partners per year, anonymous partners, drug/alcohol use during sex and prior STDs. LCA is a useful tool for identifying clusters of characteristics that may place individuals at higher risk for HIV infection and who may benefit most from PrEP in clinical practice.

  10. Precision Assembly of Systems on Surfaces (PASS)

    Science.gov (United States)

    2015-02-06

    Precision Assembly of Systems on Surfaces ( PASS ) This program was directed at generating functionalized surfaces and assemblies for electronic and...journals: Number of Papers published in non peer-reviewed journals: Final Report: Precision Assembly of Systems on Surfaces ( PASS ) Report Title This...PRECISION ASSEMBLY OF SYSTEMS ON SURFACES ( PASS ) PI: Timothy M. Swager Massachusetts Institute of Technology Final Report: DARPA, Defense

  11. 33 CFR 117.311 - New Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false New Pass. 117.311 Section 117.311... REGULATIONS Specific Requirements Florida § 117.311 New Pass. The drawspan for the State Road 789 Drawbridge... must be passed at anytime....

  12. Framing HIV Pre-Exposure Prophylaxis (PrEP) for the General Public: How Inclusive Messaging May Prevent Prejudice from Diminishing Public Support.

    Science.gov (United States)

    Calabrese, Sarah K; Underhill, Kristen; Earnshaw, Valerie A; Hansen, Nathan B; Kershaw, Trace S; Magnus, Manya; Krakower, Douglas S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

    2016-07-01

    Strategic framing of public messages about HIV pre-exposure prophylaxis (PrEP) may influence public support for policies and programs affecting access. This survey study examined how public attitudes toward PrEP differed based on the social group PrEP was described as benefiting ("beneficiary") and the moderating effect of prejudice. Members of the general public (n = 154) recruited online were randomly assigned to three beneficiary conditions: general population, gay men, or Black gay men. All participants received identical PrEP background information before completing measures of PrEP attitudes (specifying beneficiary), racism, and heterosexism. Despite anticipating greater PrEP adherence among gay men and Black gay men and perceiving PrEP as especially beneficial to the latter, participants expressed lower support for policies/programs making PrEP affordable for these groups vs. the general population. This disparity in support was stronger among participants reporting greater prejudice. Inclusive framing of PrEP in public discourse may prevent prejudice from undermining implementation efforts.

  13. Tracking particles by passing messages between images

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Laboratory; Kroc, Lukas [Los Alamos National Laboratory; Zdeborova, Lenka [Los Alamos National Laboratory; Krakala, Florent [ESPCI; Vergassola, M [CNRS

    2009-01-01

    Methods to extract information from the tracking of mobile objects/particles have broad interest in biological and physical sciences. Techniques based on the simple criterion of proximity in time-consecutive snapshots are useful to identify the trajectories of the particles. However, they become problematic as the motility and/or the density of the particles increases because of the uncertainties on the trajectories that particles have followed during the acquisition time of the images. Here, we report efficient methods for learning parameters of the dynamics of the particles from their positions in time-consecutive images. Our algorithm belongs to the class of message-passing algorithms, also known in computer science, information theory and statistical physics under the name of Belief Propagation (BP). The algorithm is distributed, thus allowing parallel implementation suitable for computations on multiple machines without significant inter-machine overhead. We test our method on the model example of particle tracking in turbulent flows, which is particularly challenging due to the strong transport that those flows produce. Our numerical experiments show that the BP algorithm compares in quality with exact Markov Chain Monte-Carlo algorithms, yet BP is far superior in speed. We also suggest and analyze a random-distance model that provides theoretical justification for BP accuracy. Methods developed here systematically formulate the problem of particle tracking and provide fast and reliable tools for its extensive range of applications.

  14. Tracking particles by passing messages between images

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Laboratory; Kroc, Lukas [Los Alamos National Laboratory; Zdeborova, Lenka [Los Alamos National Laboratory; Krakala, Florent [ESPCI; Vergassola, M [CNRS

    2009-01-01

    Methods to extract information from the tracking of mobile objects/particles have broad interest in biological and physical sciences. Techniques based on the simple criterion of proximity in time-consecutive snapshots are useful to identify the trajectories of the particles. However, they become problematic as the motility and/or the density of the particles increases because of the uncertainties on the trajectories that particles have followed during the acquisition time of the images. Here, we report efficient methods for learning parameters of the dynamics of the particles from their positions in time-consecutive images. Our algorithm belongs to the class of message-passing algorithms, also known in computer science, information theory and statistical physics under the name of Belief Propagation (BP). The algorithm is distributed, thus allowing parallel implementation suitable for computations on multiple machines without significant inter-machine overhead. We test our method on the model example of particle tracking in turbulent flows, which is particularly challenging due to the strong transport that those flows produce. Our numerical experiments show that the BP algorithm compares in quality with exact Markov Chain Monte-Carlo algorithms, yet BP is far superior in speed. We also suggest and analyze a random-distance model that provides theoretical justification for BP accuracy. Methods developed here systematically formulate the problem of particle tracking and provide fast and reliable tools for its extensive range of applications.

  15. Triplets pass their pressure test

    CERN Multimedia

    2007-01-01

    All the LHC inner triplets have now been repaired and are in position. The first ones have passed their pressure tests with flying colours. The repaired inner triplet at LHC Point 1, right side (1R). Ranko Ostojic (on the right), who headed the team responsible for repairing the triplets, shows the magnet to Robert Zimmer, President of the University of Chicago and of Fermi Research Alliance, who visited CERN on 20th August.Three cheers for the triplets! All the LHC inner triplets have now been repaired and are in position in the tunnel. Thanks to the mobilisation of a multidisciplinary team from CERN and Fermilab, assisted by the KEK Laboratory and the Lawrence Berkeley National Laboratory (LBNL), a solution has been found, tested, validated and applied. At the end of March this year, one of the inner triplets at Point 5 failed to withstand a pressure test. A fault was identified in the supports of two out of the three quadruple magne...

  16. Pass-by-Subclass Parameters

    DEFF Research Database (Denmark)

    Madsen, Anders Bach; Ernst, Erik

    2010-01-01

    on the local context as well as more remote declarations for the raw material to build these expressions. We consider these issues in context of an imperative language, and hence we need to obtain immutable references to entities accessible via mutable references. This is crucial when those entities are used...... as first class packages, i.e., when lookups into these entities are used to obtain types. The combination of these two features---the ability to obtain an immutable reference from a mutable reference, and the ability to perform computations on types---give rise to a surprisingly complex computational...

  17. 33 CFR 110.196 - Sabine Pass Channel, Sabine Pass, Tex.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sabine Pass Channel, Sabine Pass, Tex. 110.196 Section 110.196 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.196 Sabine Pass Channel, Sabine Pass,...

  18. 78 FR 62657 - Proposed Information Collection; The Interagency Access Pass and Senior Pass Application Processes

    Science.gov (United States)

    2013-10-22

    ... National Park Service Proposed Information Collection; The Interagency Access Pass and Senior Pass... Parks and Federal Recreation Lands Pass Program covers recreation opportunities on public lands managed... U.S. Forest Service. The passes provide U.S. citizens and visitors an affordable and convenient...

  19. Acceptability of HIV Pre-Exposure Prophylaxis (PrEP) and Implementation Challenges Among Men Who Have Sex with Men in India: A Qualitative Investigation.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Mengle, Shruta; Varghese, Jarvis; Nelson, Ruban; Bharat, Shalini

    2015-10-01

    This qualitative study explored the acceptability of HIV pre-exposure prophylaxis (PrEP) among MSM in India, and identified facilitators and barriers to future PrEP uptake. In 2014, we conducted 10 focus groups (n=61) among a purposive sample of diverse MSM recruited through community-based organizations in Chennai and Mumbai, and 10 key informant interviews with community leaders and health care providers. Participants' mean age was 26.1 years (SD 4.8); 62% completed secondary education, and 42% engaged in sex work. No focus group participants had heard of PrEP, but once explained, most reported they would likely use it. PrEP was alternately perceived as a 'back-up plan', a condom substitute, or a burden with concurrent condom use. Facilitators were potential for covert use, sex without condoms, and anxiety-less sex. Potential barriers emerged around stigma associated with PrEP use, fear of disclosures to one's family, wife, or male steady partner, and being labeled as HIV-positive or promiscuous by peers. Preferences emerged for intermittent rather than daily PrEP use, injectable PrEP, and free or subsidized access through community organizations or government hospitals. Key informants expressed additional concerns about risk compensation, non-adherence, and impact on ART availability for treatment. Demonstration projects are needed in India to support PrEP implementation tailored for at-risk MSM. Educational interventions for MSM should address concerns about PrEP effectiveness, side effects, and mitigate risk compensation. Community engagement may facilitate broad acceptability and challenge stigma around PrEP use. Importantly, provision of free or subsidized PrEP is necessary to making implementation feasible among low socioeconomic status MSM in India.

  20. Comparison of Dental Students' Academic Performance Using Honors/Pass/Fail and Letter Grades.

    Science.gov (United States)

    Leske, Gary S.; Ripa, Louis

    1985-01-01

    Performance in a second-year course in pedodontics/orthodontics for three classes at the State University of New York at Stony Brook School of Dental Medicine who received grades under an honors/pass/fail system was compared to that of three academically comparable classes that received letter grades. (Author/MLW)

  1. Comparison of Dental Students' Academic Performance Using Honors/Pass/Fail and Letter Grades.

    Science.gov (United States)

    Leske, Gary S.; Ripa, Louis

    1985-01-01

    Performance in a second-year course in pedodontics/orthodontics for three classes at the State University of New York at Stony Brook School of Dental Medicine who received grades under an honors/pass/fail system was compared to that of three academically comparable classes that received letter grades. (Author/MLW)

  2. The Process of Retirement Planning Scale (PRePS): development and validation.

    Science.gov (United States)

    Noone, Jack H; Stephens, Christine; Alpass, Fiona

    2010-09-01

    Although a substantial proportion of the western population is approaching retirement age, little is known about how they are preparing for the future. Much attention has been paid to the consumption of educational material and retirement wealth in the present literature, but the process of retirement planning has been ignored. S. L. Friedman and E. K. Scholnick's (1997) theoretical model provided the basis for a comprehensive measure of retirement planning. According to their process theory, individuals develop an understanding of the problem, set goals, make a decision to start preparing, and finally undertake the behaviors needed to fulfill their goals. Fifty-two items were developed to assess each stage of the planning process for financial, health, lifestyle, and psychosocial retirement planning. These were tested on a population sample of 1,449 New Zealanders aged 49-60. Confirmatory factor analysis, bivariate correlations, and hierarchical regression provided support for the valid use of the measure. Necessary antecedents, such as the tendency to look to the future, and locus of control were significantly related to the Process of Retirement Planning Scale (PRePS). The PRePS also outperformed retirement planning measures used in the Health and Retirement Study (F. T. Juster & R. Suzman, 1995) after controlling for socioeconomic and psychological variables. This measure will enable social policy makers to determine which stages of retirement planning require support and intervention. The PRePS will also help to determine which domains of retirement planning predict well-being in later life and the factors which differentiate those who are planning from those who are not.

  3. Sexual Behavior, Risk Compensation, and HIV Prevention Strategies Among Participants in the San Francisco PrEP Demonstration Project: A Qualitative Analysis of Counseling Notes.

    Science.gov (United States)

    Carlo Hojilla, J; Koester, Kimberly A; Cohen, Stephanie E; Buchbinder, Susan; Ladzekpo, Deawodi; Matheson, Tim; Liu, Albert Y

    2016-07-01

    Pre-exposure prophylaxis (PrEP) is a viable HIV prevention strategy but risk compensation could undermine potential benefits. There are limited data that examine this phenomenon outside of clinical trials. We conducted a qualitative analysis of counseling notes from the San Francisco site of the US PrEP demonstration project to assess how men who have sex with men used PrEP as a prevention strategy and its impact on their sexual practices. Four major themes emerged from our analysis of 130 distinct notes associated with 26 participants. Prevention strategy decision-making was dynamic, often influenced by the context and perceived risk of a sexual encounter. Counselors noted that participants used PrEP in conjunction with other health promotion strategies like condoms, asking about HIV status of their sex partners, and seroadaptation. With few exceptions, existing risk reduction strategies were not abandoned upon initiation of PrEP. Risk-taking behavior was 'seasonal' and fluctuations were influenced by various personal, psychosocial, and health-related factors. PrEP also helped relieve anxiety regarding sex and HIV, particularly among serodiscordant partners. Understanding sexual decision-making and how PrEP is incorporated into existing prevention strategies can help inform future PrEP implementation efforts.

  4. Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study

    DEFF Research Database (Denmark)

    Schledermann, Doris; Hyldebrandt, Tina; Ejersbo, Dorthe;

    2007-01-01

    The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening ...

  5. Oral pre-exposure prophylaxis (PrEP) for prevention of HIV in serodiscordant heterosexual couples in the United States: opportunities and challenges.

    Science.gov (United States)

    McMahon, James M; Myers, Julie E; Kurth, Ann E; Cohen, Stephanie E; Mannheimer, Sharon B; Simmons, Janie; Pouget, Enrique R; Trabold, Nicole; Haberer, Jessica E

    2014-09-01

    Oral HIV pre-exposure prophylaxis (PrEP) is a promising new biomedical prevention approach in which HIV-negative individuals are provided with daily oral antiretroviral medication for the primary prevention of HIV-1. Several clinical trials have demonstrated efficacy of oral PrEP for HIV prevention among groups at high risk for HIV, with adherence closely associated with level of risk reduction. In the United States (US), three groups have been prioritized for initial implementation of PrEP-injection drug users, men who have sex with men at substantial risk for HIV, and HIV-negative partners within serodiscordant heterosexual couples. Numerous demonstration projects involving PrEP implementation among MSM are underway, but relatively little research has been devoted to study PrEP implementation in HIV-serodiscordant heterosexual couples in the US. Such couples face a unique set of challenges to PrEP implementation at the individual, couple, and provider level with regard to PrEP uptake and maintenance, adherence, safety and toxicity, clinical monitoring, and sexual risk behavior. Oral PrEP also provides new opportunities for serodiscordant couples and healthcare providers for primary prevention and reproductive health. This article provides a review of the critical issues, challenges, and opportunities involved in the implementation of oral PrEP among HIV-serodiscordant heterosexual couples in the US.

  6. Numerical analysis on solidification process and heat transfer of FGH95 superalloy droplets during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming Chen; Benfu Hu; Yiwen Zhang; Quanmao Yu; Huiying Li

    2003-01-01

    In order to understand the relation between microstructure of superalloy powders and its solidification progress, the processing parameters are optimized during plasma rotating electrode processing (PREP). It was predicted from the results that the droplet velocities, droplet temperature, and fractional solidification with flight time about FGH95 superalloy droplet have been carried out based on Newtonian heat transfer formulation coupled with the classical heterogeneous nucleation and the specific solidification process. It has been found that the droplet dynamic and thermal behavior is strongly affected by the distribution of droplet diameters,the proportion of cooling atmosphere, but is relatively unaffected by the droplet superheat.

  7. Photoacoustic Soot Spectrometer (PASS) Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Dubey, M [Los Alamos National Laboratory; Springston, S [Brookhaven National Laboratory; Koontz, A [Pacific Northwest National Laboratory; Aiken, A [Los Alamos National Laboratory

    2013-01-17

    The photoacoustic soot spectrometer (PASS) measures light absorption by aerosol particles. As the particles pass through a laser beam, the absorbed energy heats the particles and in turn the surrounding air, which sets off a pressure wave that can be detected by a microphone. The PASS instruments deployed by ARM can also simultaneously measure the scattered laser light at three wavelengths and therefore provide a direct measure of the single-scattering albedo. The Operator Manual for the PASS-3100 is included here with the permission of Droplet Measurement Technologies, the instrument’s manufacturer.

  8. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Directory of Open Access Journals (Sweden)

    Luís Miguel Rocha

    2014-11-01

    Full Text Available Introduction: Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013 were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods: A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results: A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%; those that were aware, had heard of it trough CheckpointLx (31%, internet (22% or health professionals (20%. 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%. Type of PrEP preferred was oral, a pill a day (43%, followed by oral, intermittent intake (32%. Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions: In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP, according to MSM Risk Index

  9. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Science.gov (United States)

    Miguel Rocha, Luís; José Campos, Maria; Brito, João; Fuertes, Ricardo; Rojas, Jesus; Pinto, Nuno; Mendão, Luís; Esteves, Julio

    2014-01-01

    Introduction Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%); those that were aware, had heard of it trough CheckpointLx (31%), internet (22%) or health professionals (20%). 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%). Type of PrEP preferred was oral, a pill a day (43%), followed by oral, intermittent intake (32%). Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP), according to MSM Risk Index in 2014 USA PrEP

  10. Alcohol based surgical prep solution and the risk of fire in the operating room: a case report

    Directory of Open Access Journals (Sweden)

    Gupta Rajiv

    2008-04-01

    Full Text Available Abstract A few cases of fire in the operating room are reported in the literature. The factors that may initiate these fires are many and include alcohol based surgical prep solutions, electrosurgical equipment, flammable drapes etc. We are reporting a case of fire in the operating room while operating on a patient with burst fracture C6 vertebra with quadriplegia. The cause of the fire was due to incomplete drying of the covering drapes with an alcohol based surgical prep solution. This paper discusses potential preventive measures to minimize the incidence of fire in the operating room.

  11. 78 FR 25432 - Sabine Pass LNG, L.P., Sabine Pass Liquefaction, LLC; Notice of Availability of the Environmental...

    Science.gov (United States)

    2013-05-01

    ... Energy Regulatory Commission Sabine Pass LNG, L.P., Sabine Pass Liquefaction, LLC; Notice of Availability... Sabine Pass Sabine Pass LNG, L.P. and Sabine Pass Liquefaction, LLC (Sabine Pass) in the above-referenced... construction at the existing Sabine Pass LNG terminal in Cameron Parish, Louisiana. The EA assesses...

  12. Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature.

    Science.gov (United States)

    Koechlin, Florence M; Fonner, Virginia A; Dalglish, Sarah L; O'Reilly, Kevin R; Baggaley, Rachel; Grant, Robert M; Rodolph, Michelle; Hodges-Mameletzis, Ioannis; Kennedy, Caitlin E

    2016-11-29

    Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP. A comprehensive search strategy reviewed three electronic databases of articles and HIV-related conference abstracts (January 1990-April 2015). Data abstraction used standardised forms to categorise by population groups and relevant themes. Of 3068 citations screened, 76 peer-reviewed articles and 28 conference abstracts were included. Geographic coverage was global. Most studies (N = 78) evaluated hypothetical use of PrEP, while 26 studies included individuals who actually took PrEP or placebo. Awareness of PrEP was low, but once participants were presented with information about PrEP, the majority said they would consider using it. Concerns about safety, side effects, cost and effectiveness were the most frequently cited barriers to use. There was little indication of risk compensation. Healthcare providers would consider prescribing PrEP, but need more information before doing so. Findings from a rapidly expanding evidence base suggest that the majority of populations most likely to benefit from PrEP feel positively towards it. These same populations would benefit from overcoming current implementation challenges with the shortest possible delay.

  13. Complex and Conflicting Social Norms: Implications for Implementation of Future HIV Pre-Exposure Prophylaxis (PrEP Interventions in Vancouver, Canada.

    Directory of Open Access Journals (Sweden)

    Rod Knight

    Full Text Available HIV Pre-Exposure Prophylaxis (PrEP has been found to be efficacious in preventing HIV acquisition among seronegative individuals in a variety of risk groups, including men who have sex with men and people who inject drugs. To date, however, it remains unclear how socio-cultural norms (e.g., attitudes towards HIV; social understandings regarding HIV risk practices may influence the scalability of future PrEP interventions. The objective of this study is to assess how socio-cultural norms may influence the implementation and scalability of future HIV PrEP interventions in Vancouver, Canada.We conducted 50 interviews with young men (ages 18-24 with a variety of HIV risk behavioural profiles (e.g., young men who inject drugs; MSM. Interviews focused on participants' experiences and perceptions with various HIV interventions and policies, including PrEP.While awareness of PrEP was generally low, perceptions about the potential personal and public health gains associated with PrEP were interconnected with expressions of complex and sometimes conflicting social norms. Some accounts characterized PrEP as a convenient form of reliable protection against HIV, likening it to the female birth control pill. Other accounts cast PrEP as a means to facilitate 'socially unacceptable' behaviour (e.g., promiscuity. Stigmatizing rhetoric was used to position PrEP as a tool that could promote some groups' proclivities to take 'risks'.Stigma regarding 'risky' behaviour and PrEP should not be underestimated as a serious implementation challenge. Pre-implementation strategies that concomitantly aim to improve knowledge about PrEP, while addressing associated social prejudices, may be key to effective implementation and scale-up.

  14. One pass learning for generalized classifier neural network.

    Science.gov (United States)

    Ozyildirim, Buse Melis; Avci, Mutlu

    2016-01-01

    Generalized classifier neural network introduced as a kind of radial basis function neural network, uses gradient descent based optimized smoothing parameter value to provide efficient classification. However, optimization consumes quite a long time and may cause a drawback. In this work, one pass learning for generalized classifier neural network is proposed to overcome this disadvantage. Proposed method utilizes standard deviation of each class to calculate corresponding smoothing parameter. Since different datasets may have different standard deviations and data distributions, proposed method tries to handle these differences by defining two functions for smoothing parameter calculation. Thresholding is applied to determine which function will be used. One of these functions is defined for datasets having different range of values. It provides balanced smoothing parameters for these datasets through logarithmic function and changing the operation range to lower boundary. On the other hand, the other function calculates smoothing parameter value for classes having standard deviation smaller than the threshold value. Proposed method is tested on 14 datasets and performance of one pass learning generalized classifier neural network is compared with that of probabilistic neural network, radial basis function neural network, extreme learning machines, and standard and logarithmic learning generalized classifier neural network in MATLAB environment. One pass learning generalized classifier neural network provides more than a thousand times faster classification than standard and logarithmic generalized classifier neural network. Due to its classification accuracy and speed, one pass generalized classifier neural network can be considered as an efficient alternative to probabilistic neural network. Test results show that proposed method overcomes computational drawback of generalized classifier neural network and may increase the classification performance. Copyright

  15. 33 CFR 117.487 - Pierre Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pierre Pass. 117.487 Section 117.487 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.487 Pierre Pass. The draw of the S70...

  16. Ulysses Passes South Pole of Sun

    Institute of Scientific and Technical Information of China (English)

    程林

    1995-01-01

    On the 14th of September,1994, the fastest scientific instrument in space passed the south pole of the Sun,a place where no human-made object has been before. A spaceprobe called Ulysses made the polar pass at about midday as it continued to collect data on the solar wind,a stream of high-energy sub-atomic

  17. 33 CFR 117.484 - Pass Manchac.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pass Manchac. 117.484 Section 117.484 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.484 Pass Manchac. The draw of the...

  18. 33 CFR 117.303 - Matlacha Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Matlacha Pass. 117.303 Section 117.303 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.303 Matlacha Pass. The draw of the...

  19. Eco prep: the economical preparation of ceramic bodies; Ecoprep: la preparacion rentable de masas ceramicas

    Energy Technology Data Exchange (ETDEWEB)

    Luders, M.; Walter, H. J.; Nold, P.; Lobe, R.; Muller, M.; Gerl, S.

    2012-07-01

    Eco prep (Economic Preparation) is the sustainable technology for preparing ceramic bodies with a minimum consumption of resources. It has a huge impact on the energy balance and eliminates the need for additives to generate a high-quality slip to make granules. In consequence Eco prep delivers a significant reduction in production costs, bringing an investment in this technology to the break-even point after a very short time. Reduction in water consumption and additives and the use of new raw materials are other advantages that impulse the implementation of this production technology, as well as important reduction of CO{sub 2} emissions, contributing to meeting the goals of the Kyoto Protocol. In short: A technology already successfully applied in different industries for decades, that includes a compendium of measures based on saving reductions in a range from 66% (energy, water,) and 100% (additives, deflocculants, etc.) and will mark the future in micro granulation processes also in the ceramic industry. (Author)

  20. The PREP pipeline: standardized preprocessing for large-scale EEG analysis.

    Science.gov (United States)

    Bigdely-Shamlo, Nima; Mullen, Tim; Kothe, Christian; Su, Kyung-Min; Robbins, Kay A

    2015-01-01

    The technology to collect brain imaging and physiological measures has become portable and ubiquitous, opening the possibility of large-scale analysis of real-world human imaging. By its nature, such data is large and complex, making automated processing essential. This paper shows how lack of attention to the very early stages of an EEG preprocessing pipeline can reduce the signal-to-noise ratio and introduce unwanted artifacts into the data, particularly for computations done in single precision. We demonstrate that ordinary average referencing improves the signal-to-noise ratio, but that noisy channels can contaminate the results. We also show that identification of noisy channels depends on the reference and examine the complex interaction of filtering, noisy channel identification, and referencing. We introduce a multi-stage robust referencing scheme to deal with the noisy channel-reference interaction. We propose a standardized early-stage EEG processing pipeline (PREP) and discuss the application of the pipeline to more than 600 EEG datasets. The pipeline includes an automatically generated report for each dataset processed. Users can download the PREP pipeline as a freely available MATLAB library from http://eegstudy.org/prepcode.

  1. Houston Pre-Freshman Enrichment Program (Houston PREP). Final report, June 9, 1997--July 25, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The 1997 Houston Pre-Freshman Enrichment Program (PREP) was conducted at the campus of the University of Houston-Downtown from June 9 to July 25, 1997. Program participants were recruited from the Greater Houston Area. All participants were identified as high-achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Clear Creek, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 194 students starting the program, 165 students were from economically and socially disadvantage groups under-represented in the engineering and science professions, and 118 of the 194 were women. Our First Year group for 1997 composed of 96% minority and women students. Second and Third Year students combined were 96% minority or women. With financial support from the Center for Computational Sciences and Advanced Distributed Simulation, the Fourth Year Program was added to PREP this year. Twelve students completed the program (83% minority or women).

  2. "Racializing" Class

    Science.gov (United States)

    Hatt-Echeverria, Beth; Urrieta, Luis, Jr.

    2003-01-01

    In an effort to explore how racial and class oppressions intersect, the authors use their autobiographical narratives to depict cultural and experiential continuity and discontinuity in growing up white working class versus Chicano working class. They specifically focus on "racializing class" due to the ways class is often used as a copout by…

  3. Verification of Faulty Message Passing Systems with Continuous State Space in PVS

    Science.gov (United States)

    Pilotto, Concetta; White, Jerome

    2010-01-01

    We present a library of Prototype Verification System (PVS) meta-theories that verifies a class of distributed systems in which agent commu nication is through message-passing. The theoretic work, outlined in, consists of iterative schemes for solving systems of linear equations , such as message-passing extensions of the Gauss and Gauss-Seidel me thods. We briefly review that work and discuss the challenges in formally verifying it.

  4. Message Passing Algorithms for Compressed Sensing: I. Motivation and Construction

    CERN Document Server

    Donoho, David L; Montanari, Andrea

    2009-01-01

    In a recent paper, the authors proposed a new class of low-complexity iterative thresholding algorithms for reconstructing sparse signals from a small set of linear measurements \\cite{DMM}. The new algorithms are broadly referred to as AMP, for approximate message passing. This is the first of two conference papers describing the derivation of these algorithms, connection with the related literature, extensions of the original framework, and new empirical evidence. In particular, the present paper outlines the derivation of AMP from standard sum-product belief propagation, and its extension in several directions. We also discuss relations with formal calculations based on statistical mechanics methods.

  5. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  6. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  7. Cost-effectiveness of PrEP in HIV/AIDS control in Zambia: a stochastic league approach

    NARCIS (Netherlands)

    Nichols, B.E.; Baltussen, R.M.; Dijk, J.H. van; Thuma, P.E.; Nouwen, J.L.; Boucher, C.A.B.; Vijver, D.A. van de

    2014-01-01

    BACKGROUND: Earlier antiretroviral therapy initiation and pre-exposure prophylaxis (PrEP) prevent HIV, although at a substantial cost. We use mathematical modeling to compare the cost-effectiveness and economic affordability of antiretroviral-based prevention strategies in rural Macha, Zambia.

  8. Vulnerable infected populations and street markets for ARVs: Potential implications for PrEP rollout in the USA.

    Science.gov (United States)

    Kurtz, Steven P; Buttram, Mance E; Surratt, Hilary L

    2014-04-01

    Widespread diversion of antiretroviral (ARV) medications to illicit markets has recently been documented among indigent patients in South Florida. The recent approval of ARVs for pre-exposure prophylaxis (PrEP) has the potential to broaden these illicit markets, as high-risk individuals seek ARVs without a prescription or medical supervision. Nonadherence among diverters and unsupervised use of ARVs for treatment or PrEP increase risks of treatment failure, drug resistance, and disease transmission. We report the scope of ARV diversion among substance-using men who have sex with men in South Florida. Structured interviews (N = 515) queried demographics, HIV status, mental distress, substance dependence, and sexual risks. HIV-positive participants answered questions about medical care, treatment, and ARV adherence and diversion. Median age was 39. Of 46.4% who were HIV-positive, 79.1% were prescribed ARVs. Of these, 27% reported selling/trading ARVs. Reasons for diversion were sharing/trading with friends, sale/trade for money/drugs, and sale/trade of unused medications. ARV diverters, compared to nondiverters, were more likely to be substance dependent (74.5% vs. 58.7%, p = 0.046) and have traded sex for money/drugs (60.8% vs. 32.6%, p system. The implications of diversion for increased risks of treatment failure, disease transmission, and PrEP failure should be carefully considered in developing policy and behavioral supports to scaling up treatment as prevention and PrEP.

  9. Saying 'No' to PrEP research in Malawi: what constitutes 'failure' in offshored HIV prevention research?

    Science.gov (United States)

    Peterson, Kristin; Folayan, Morenike Oluwatoyin; Chigwedere, Edward; Nthete, Evaristo

    2015-12-01

    Between 2004 and 2005, the first multi-sited clinical trial tested whether an existing, marketed antiretroviral drug, Tenofovir (TDF), could prevent HIV transmission. Referred to as pre-exposure prophylaxis (PrEP), most of these trial sites prematurely closed down. Two sites located in Cambodia and Cameroon received international media attention. But little attention was drawn to sites in Malawi and Nigeria, where university ethicists and research scientists extensively debated PrEP. This article focuses on events that took place in Malawi where there was a prolonged dispute over the scientific rationales of PrEP and not trial specific ethics referred to as 'bioethics'. Specifically, the article discusses debates pertaining to three PrEP trial protocols that were refused ethics approval in Malawi between 2004 and 2009. It is argued that HIV science debates in Malawi are embedded in postcolonial politics--geopolitical histories and state and household economic dispossessions that have created the structural possibilities for Malawi to become an offshore destination for HIV clinical research. As such, ethics in this case does not pertain to trial or bioethical 'failures'. Rather, ethics is located at the scale of imperial relations that give rise to multiple, often invisible, research concerns and constraints.

  10. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP in clinical settings to prevent HIV infection.

    Directory of Open Access Journals (Sweden)

    Emily A Arnold

    Full Text Available BACKGROUND: A recent clinical trial demonstrated that a daily dose tenofovir disoproxil fumarate and emtricitabrine (TDF-FTC can reduce HIV acquisition among men who have sex with men (MSM and transgender (TG women by 44%, and up to 90% if taken daily. We explored how medical and service providers understand research results and plan to develop clinical protocols to prescribe, support and monitor adherence for patients on PrEP in the United States. METHODS: Using referrals from our community collaborators and snowball sampling, we recruited 22 healthcare providers in San Francisco, Oakland, and Los Angeles for in-depth interviews from May-December 2011. The providers included primary care physicians seeing high numbers of MSM and TG women, HIV specialists, community health clinic providers, and public health officials. We analyzed interviews thematically to produce recommendations for setting policy around implementing PrEP. Interview topics included: assessing clinician impressions of PrEP and CDC guidance, considerations of cost, office capacity, dosing schedules, and following patients over time. RESULTS: Little or no demand for PrEP from patients was reported at the time of the interviews. Providers did not agree on the most appropriate patients for PrEP and believed that current models of care, which do not involve routine frequent office visits, were not well suited for prescribing PrEP. Providers detailed the need to build capacity and were concerned about monitoring side effects and adherence. PrEP was seen as potentially having impact on the epidemic but providers also noted that community education campaigns needed to be tailored to effectively reach specific vulnerable populations. CONCLUSIONS: While PrEP may be a novel and clinically compelling prevention intervention for MSM and TG women, it raises a number of important implementation challenges that would need to be addressed. Nonetheless, most providers expressed optimism that

  11. Introduction of the Thin Prep Imaging System™ (TIS: experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-02-01

    Full Text Available Abstract Objective Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women's Hospital. We introduced the TIS in December 2004. Methods The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003–November 2004 are taken as the historic control group for our study. Results The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022. The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  12. 77 FR 65546 - Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P.; Notice of Petition To Amend Authorizations...

    Science.gov (United States)

    2012-10-29

    ... Energy Regulatory Commission Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P.; Notice of Petition To... Pass Liquefaction, LLC and Sabine Pass LNG, L.P. (collectively, Sabine Pass), 700 Milam Street, Suite... and operate certain related facilities (Modification Project) at the existing Sabine Pass LNG...

  13. 78 FR 62319 - Golden Pass Products, LLC, Golden Pass Pipeline, LLC; Notice of Intent To Prepare an...

    Science.gov (United States)

    2013-10-16

    ... Energy Regulatory Commission Golden Pass Products, LLC, Golden Pass Pipeline, LLC; Notice of Intent To Prepare an Environmental Assessment for the Planned Golden Pass LNG Export Project and Golden Pass Export... operation of the Golden Pass Liquefied Natural Gas (LNG) Project and Golden Pass Export Pipeline...

  14. 78 FR 66909 - Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P.; Notice of Application to Amend...

    Science.gov (United States)

    2013-11-07

    ... Energy Regulatory Commission Sabine Pass Liquefaction, LLC; Sabine Pass LNG, L.P.; Notice of Application... Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P. (collectively, Sabine Pass), 700 Milam Street...,006 Bcf per year). Sabine Pass' requested increase in authorized capacity is an increase from...

  15. Incentive Pass-through for Residential Solar Systems in California

    Energy Technology Data Exchange (ETDEWEB)

    Dong, C. G. [Univ. of Texas, Austin, TX (United States); Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rai, Varun [Univ. of Texas, Austin, TX (United States)

    2014-10-01

    The deployment of solar photovoltaic (PV) systems has grown rapidly over the last decade, partly because of various government incentives. In the United States, among the largest and longest-running incentives have been those established in California. Building on past research, this report addresses the still-unanswered question: to what degree have the direct PV incentives in California been passed through from installers to consumers? This report helps address this question by carefully examining the residential PV market in California (excluding a certain class of third-party-owned PV systems) and applying both a structural-modeling approach and a reduced-form regression analysis to estimate the incentive pass-through rate. The results suggest an average pass-through rate of direct incentives of nearly 100%, though with regional differences among California counties. While these results could have multiple explanations, they suggest a relatively competitive market and well-functioning subsidy program. Further analysis is required to determine whether similar results broadly apply to other states, to other customer segments, to all third-party-owned PV systems, or to all forms of financial incentives for solar (considering not only direct state subsidies, but also utility electric bill savings and federal tax incentives).

  16. PENGATURAN PASSING OFF DALAM PENGGUNAAN DOMAIN NAME TERKAIT DENGAN MEREK

    Directory of Open Access Journals (Sweden)

    Herti Yunita Putri

    2016-09-01

    Full Text Available In cyber world we often hear about domain name’s term. Domain name is a unique name to identify the server computer’s name like a web server or email server on a computer network or Internet. Passing off also make causes confusion in using merk from a famous brand or merk on the goods and services. Selected domain name in the internet media often creates the similar domain name with the other parties. This similar domain name are often used by people who are not responsible to take advantages of the domain name for themself. This can be caused by the presence of competition from Internet media business. This things called passing off. This research is a normative juridical research with a qualitative analysis. The legal materials include primary legal, secondary law and tertiary legal materials. Collection technique applied is literary study. Legal materials were analyzed to see the argument implementation of the definition of merk, the definition of domain name, definition of passing off, passing off in use related by merk and domain name and the rules of law in Indonesia related by merk, domain name and passing off. Big wishes in the future it can assist as a basic reference and legal considerations which are useful in Indonesian law practice. There are two passing off related to the merk and domain name, called Crybersquatting and Tiposquatting. Domain name rules are not regulated clearly in merk regulation named Act No. 15 of 2001. It regulated in PP 24 Year 1993 about The Class List of Goods or Services In Merk, Telecommunications are included in the goods or services in merk. Domain name are regulated in UDRP (Uniform Dispute Resolution Policy with competent institutions called ICANN (Internet Corporation for Assigned Names and Numbers. Dalam dunia maya (cyber world, kita sering mendengar istilah domain name. Domain name adalah nama unik yang diberikan untuk mengidentifikasi nama server komputer seperti web server atau email server di

  17. Message passing for quantified Boolean formulas

    CERN Document Server

    Zhang, Pan; Zdeborová, Lenka; Zecchina, Riccardo

    2012-01-01

    We introduce two types of message passing algorithms for quantified Boolean formulas (QBF). The first type is a message passing based heuristics that can prove unsatisfiability of the QBF by assigning the universal variables in such a way that the remaining formula is unsatisfiable. In the second type, we use message passing to guide branching heuristics of a Davis-Putnam Logemann-Loveland (DPLL) complete solver. Numerical experiments show that on random QBFs our branching heuristics gives robust exponential efficiency gain with respect to the state-of-art solvers. We also manage to solve some previously unsolved benchmarks from the QBFLIB library. Apart from this our study sheds light on using message passing in small systems and as subroutines in complete solvers.

  18. How to pass higher English colour

    CERN Document Server

    Bridges, Ann

    2009-01-01

    How to Pass is the Number 1 revision series for Scottish qualifications across the three examination levels of Standard Grade, Intermediate and Higher! Second editions of the books present all of the material in full colour for the first time.

  19. Automated Procedure for Roll Pass Design

    Science.gov (United States)

    Lambiase, F.; Langella, A.

    2009-04-01

    The aim of this work has been to develop an automatic roll pass design method, capable of minimizing the number of roll passes. The adoption of artificial intelligence technologies, particularly expert systems, and a hybrid model for the surface profile evaluation of rolled bars, has allowed us to model the search for the minimal sequence with a tree path search. This approach permitted a geometrical optimization of roll passes while allowing automation of the roll pass design process. Moreover, the heuristic nature of the inferential engine contributes a great deal toward reducing search time, thus allowing such a system to be employed for industrial purposes. Finally, this new approach was compared with other recently developed automatic systems to validate and measure possible improvements among them.

  20. Torch Relay:Love Is Passing on

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ May is not an ordinary month for the whole China, as the 8.0-magnitude earthquake hit sonthwest of China and shocked thc whole nation. And now, the torch relay in China is endowed with more responsibility and significance: to pass on the passion, also the compassion. No matter the torch relay is paused or going on, Olym-pic spirit is passing on. So is the love.

  1. SCALAR MULTI-PASS ATOMIC MAGNETOMETER

    Science.gov (United States)

    2017-08-01

    active volume including relaxation on cell walls. 4 Approved for public release; distribution is unlimited. Fig. 6...measurements, and suppression of spin-exchange relaxation to achieve the highest sensitivity per unit volume. We developed a new multi-pass cell geometry...suppression of spin-exchange relaxation to achieve the highest sensitivity per unit volume. During the project we developed a new multi-pass cell geometry

  2. Willingness to use pre-exposure prophylaxis (PrEP for HIV prevention among men who have sex with men (MSM in Malaysia: findings from a qualitative study

    Directory of Open Access Journals (Sweden)

    Adam Bourne

    2017-01-01

    Conclusions: This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those taking it may be stigmatized, it is crucial that the use of PrEP is presented as a responsible course of action, and one of a range of strategies that men can use to keep themselves safe from HIV.

  3. Message Passing Framework for Globally Interconnected Clusters

    Science.gov (United States)

    Hafeez, M.; Asghar, S.; Malik, U. A.; Rehman, A.; Riaz, N.

    2011-12-01

    In prevailing technology trends it is apparent that the network requirements and technologies will advance in future. Therefore the need of High Performance Computing (HPC) based implementation for interconnecting clusters is comprehensible for scalability of clusters. Grid computing provides global infrastructure of interconnecting clusters consisting of dispersed computing resources over Internet. On the other hand the leading model for HPC programming is Message Passing Interface (MPI). As compared to Grid computing, MPI is better suited for solving most of the complex computational problems. MPI itself is restricted to a single cluster. It does not support message passing over the internet to use the computing resources of different clusters in an optimal way. We propose a model that provides message passing capabilities between parallel applications over the internet. The proposed model is based on Architecture for Java Universal Message Passing (A-JUMP) framework and Enterprise Service Bus (ESB) named as High Performance Computing Bus. The HPC Bus is built using ActiveMQ. HPC Bus is responsible for communication and message passing in an asynchronous manner. Asynchronous mode of communication offers an assurance for message delivery as well as a fault tolerance mechanism for message passing. The idea presented in this paper effectively utilizes wide-area intercluster networks. It also provides scheduling, dynamic resource discovery and allocation, and sub-clustering of resources for different jobs. Performance analysis and comparison study of the proposed framework with P2P-MPI are also presented in this paper.

  4. Dependent Classes

    DEFF Research Database (Denmark)

    Gasiunas, Vaidas; Mezini, Mira; Ostermann, Klaus

    2007-01-01

    Virtual classes allow nested classes to be refined in subclasses. In this way nested classes can be seen as dependent abstractions of the objects of the enclosing classes. Expressing dependency via nesting, however, has two limitations: Abstractions that depend on more than one object cannot...... be modeled and a class must know all classes that depend on its objects. This paper presents dependent classes, a generalization of virtual classes that expresses similar semantics by parameterization rather than by nesting. This increases expressivity of class variations as well as the flexibility...... of their modularization. Besides, dependent classes complement multi-methods in scenarios where multi-dispatched abstractions rather than multi-dispatched method are needed. They can also be used to express more precise signatures of multi-methods and even extend their dispatch semantics. We present a formal semantics...

  5. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    Directory of Open Access Journals (Sweden)

    Arcelino Farias-Neto

    2015-01-01

    Full Text Available Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  6. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers.

    Science.gov (United States)

    Farias-Neto, Arcelino; Gomes, Edna Maria da Cunha Ferreira; Sánchez-Ayala, Alfonso; Sánchez-Ayala, Alejandro; Vilanova, Larissa Soares Reis

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  7. Houston prefreshman enrichment program (Houston PREP). Final report, June 10, 1996--August 1, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The 1996 Houston Pre-freshman Enrichment Program (PREP) was conducted on the campus of the University of Houston-Downtown from June 10 to August 1, 1996. Program Participants were recruited from the Greater Houston area. All participants were identified as high achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Crockett, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 197 students starting the program, 170 completed, 142 students were from economically and socially disadvantage groups underrepresented in the engineering and science professions, and 121 of the 197 were female. Our First Year group for 1996 composed of 96% minority and women students. Our Second and Third Year students were 100% and 93.75% minority or women respectively. This gave an overall minority and female population of 93.75%. This year, special efforts were again made to recruit students from minority groups, which caused a significant increase in qualified applicants. However, due to space limitations, 140 applicants were rejected. Investigative and discovery learning were key elements of PREP. The academic components of the program included Algebraic Structures, Engineering, Introduction to Computer Science, Introduction to Physics, Logic and Its Application to Mathematics, Probability and Statistics, Problem Solving Seminar using computers and PLATO software, SAT Preparatory Seminars, and Technical Writing.

  8. Who should be offered HIV pre-exposure prophylaxis (PrEP)?: A secondary analysis of a Phase 3 PrEP efficacy trial in men who have sex with men and transgender women

    Science.gov (United States)

    Buchbinder, Susan P; Glidden, David V.; Liu, Albert Y.; McMahan, Vanessa; Guanira, Juan V.; Mayer, Kenneth H.; Goicochea, Pedro; Grant, Robert M.

    2014-01-01

    Background Pre-exposure prophylaxis (PrEP) has been proven to reduce HIV acquisition in men who have sex with men and transgender women (MSM/TGW). For maximal impact, PrEP should be targeted to subpopulations accounting for the largest proportion of infections (population attributable fraction, PAF) and for whom the number needed to treat (NNT) to prevent infection is lowest. Methods The iPrEx study was a randomized controlled efficacy trial of tenofovir-disoproxil-fumarate/emtricitabine PrEP in 2499 MSM/TGW on 4 continents. We calculated the association between demographic and risk behavior during screening with subsequent seroconversion among placebo recipients using a Poisson model, and the PAF and NNT for risk behavior subgroups. Findings Of 1248 placebo participants enrolled, 83 became HIV infected in follow-up. Participants reporting non-condom receptive anal intercourse (ncRAI) seroconverted significantly more often than MSM/TGW reporting no condomless anal sex (adjusted hazard ratio (AHR) 5·11, 95% CI 1·55-16·79). The overall PAF for MSM/TGW reporting ncRAI was 64% (prevalence=60%). Most of this risk came from ncRAI with unknown serostatus partners (PAF 53%, prevalence=54%, AHR 4·76); in contrast, the PAF for ncRAI with an HIV positive partner, an uncommon practice, was only 1% (prevalence 1%, AHR=7·11). The overall NNT per year for the cohort was 62 (95% CI 44-147). NNTs were lower for MSM/TGW self-reporting ncRAI, cocaine use, or a sexually transmitted infection (NNT= 36, 12, and 41 respectively). Having a single partner or non-condom insertive anal sex had the highest NNTs. Interpretation PrEP may be most effective at a population level if targeted toward MSM/TGW reporting ncRAI, even with partners perceived to be HIV negative. Substance use history and testing for STIs may also inform individual decisions to start PrEP. Considering PAF and NNT can aid in discussing the benefits and risks of PrEP with MSM/TGW. Funding Funded by the National

  9. Statistics of Epidemics in Networks by Passing Messages

    Science.gov (United States)

    Shrestha, Munik Kumar

    financial contagion gets worse with too much diversification. We also predict that financial system exhibits "robust yet fragile" behavior, with regions of the parameter space where contagion is rare but catastrophic whenever it occurs. In further results, we develop a message-passing approach to recurrent state epidemics like susceptible-infectious-susceptible and susceptible-infectious-recovered-susceptible where nodes can return to previously inhabited states and multiple waves of infection can pass through the population. Given that message-passing has been applied exclusively to models with one-way state changes like susceptible-infectious and susceptible-infectious-recovered, we develop message-passing for recurrent epidemics based on a new class of differential equations and demonstrate that our approach is simple and efficiently approximates results obtained from Monte Carlo simulation, and that the accuracy of message-passing is often superior to the pair approximation (which also takes second-order correlations into account).

  10. GE Smart Prep半自动监控软件的应用要点%Application Keypoints of GE Light Speed 8 Smart Prep Semiautomatic Monitoring Software

    Institute of Scientific and Technical Information of China (English)

    肖建明

    2011-01-01

    目的 探讨GE light speed 8 smart Prep技术在CT血管造影中的准确应用.方法 采用GE light speed 8 Smart Pmp软件对35例患者进行颅脑CTA检查.结果 总结出GE light speed 8运用smart prep 的技术要点.%Objective To investigate the application of the GE light speed 8 smart prep technique in CT angiography. Methods Used GE light speed 8 Smart Prep software to assist the check of cerebral CTA in 35 patients. Results Summarized the application keypoints of CE light speed 8 smart prep technique.

  11. Prevalence and characteristics of users of pre-exposure prophylaxis (PrEP) among men who have sex with men, San Francisco, 2014 in a cross-sectional survey: implications for disparities.

    Science.gov (United States)

    Snowden, Jonathan M; Chen, Yea-Hung; McFarland, Willi; Raymond, Henry F

    2017-02-01

    Pre-exposure prophylaxis (PrEP) has gained a central role in prevention of HIV infection among men who have sex with men (MSM), particularly in San Francisco, California, USA. Programmes to enrol men in PrEP are being undertaken by a range of public and private organisations. PrEP will have the largest population impact if it reaches men who are most at risk for HIV infection, and is used in a manner that enables maximal efficacy. Access to PrEP also needs to be equitable. We report on the characteristics of men eligible for and using PrEP. Data were from the 2014 implementation of National HIV Behavioural Surveillance (NHBS) among MSM in San Francisco. NHBS uses venue-based sampling as the national standard for sampling MSM. We compare proportions of demographic characteristics of MSM using versus not using PrEP who are HIV-negative and meet Centers for Disease Control and Prevention guidelines to recommend PrEP. Overall, 64.1% of HIV-negative MSM in San Francisco would meet guidelines for PrEP use, while 9.2% of MSM overall and 14.5% of MSM eligible were using PrEP as of 2014. Men using PrEP are more likely to be white and of older age. There were no differences between men using and not using PrEP in terms of education, income and health insurance. PrEP roll-out efforts should attempt to increase reach for young, black and Hispanic MSM. Failure to equitably provide access to PrEP could exacerbate the US disparity in new HIV infections for men of colour. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Pre-exposure Prophylaxis (PrEP) Use, Seroadaptation, and Sexual Behavior Among Men Who Have Sex with Men, San Francisco, 2004-2014.

    Science.gov (United States)

    Chen, Yea-Hung; Snowden, Jonathan M; McFarland, Willi; Raymond, H Fisher

    2016-12-01

    The Food and Drug Administration approved pre-exposure prophylaxis (PrEP) to prevent HIV infection, and the Centers for Disease Control and Prevention has presented PrEP as a prevention option for groups at high risk such as men who have sex with men (MSM). Intervention data provide some information on how PrEP affects sexual behavior of MSM in trials, open label extensions, or clinics. However, it is unclear whether sexual risk and preventive behavioral patterns are changing in the population as a whole as PrEP becomes more widely available, whether due to PrEP use or other factors. We examined trends in PrEP use, numbers of condomless anal sex partners, consistent condom use, and seroadaptive strategies in San Francisco-a city which has actively promoted PrEP-using data from National HIV Behavioral Surveillance (NHBS). NHBS recruited 1211, 383, 373, and 268 HIV-negative MSM in 2004, 2008, 2011, and 2014, respectively. PrEP use increased from zero in 2004, 2008, and 2011 to 9.6 % in 2014. The proportion of men with no condomless anal sex partners dropped from 60.6 % in 2004, to 58.2 % in 2008, to 54.2 % in 2011, to 40.2 % in 2014. Consistent condom use decreased from 36.8 % in 2004, and 30.5 % in 2008 and 2011, to 18.3 % in 2014. PrEP's introduction and scale-up enters in a pre-existing trend of decreasing condom use and increasing sexually transmitted infections among MSM which may be accelerating in recent years. While PrEP use should be scaled up as a prevention option among those who would benefit most, we believe that public health officials need to be realistic about the possibility that condom use could very well continue to decline as PrEP use increases, and to an extent that may not be directly or indirectly offset by PrEP.

  13. MAP Estimation, Message Passing, and Perfect Graphs

    CERN Document Server

    Jebara, Tony S

    2012-01-01

    Efficiently finding the maximum a posteriori (MAP) configuration of a graphical model is an important problem which is often implemented using message passing algorithms. The optimality of such algorithms is only well established for singly-connected graphs and other limited settings. This article extends the set of graphs where MAP estimation is in P and where message passing recovers the exact solution to so-called perfect graphs. This result leverages recent progress in defining perfect graphs (the strong perfect graph theorem), linear programming relaxations of MAP estimation and recent convergent message passing schemes. The article converts graphical models into nand Markov random fields which are straightforward to relax into linear programs. Therein, integrality can be established in general by testing for graph perfection. This perfection test is performed efficiently using a polynomial time algorithm. Alternatively, known decomposition tools from perfect graph theory may be used to prove perfection ...

  14. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    OpenAIRE

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R. (Rainer); Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D; Rouzioux, C

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  15. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    Science.gov (United States)

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R.; Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D.; Rouzioux, C.

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated. PMID:20129964

  16. Evaluation of an upgraded version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test for HIV-1 load quantification.

    Science.gov (United States)

    Damond, F; Avettand-Fenoel, V; Collin, G; Roquebert, B; Plantier, J C; Ganon, A; Sizmann, D; Babiel, R; Glaubitz, J; Chaix, M L; Brun-Vezinet, F; Descamps, D; Rouzioux, C

    2010-04-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  17. When are declines in condom use while using PrEP a concern? Modelling insights from a Hillbrow, South Africa case study

    Directory of Open Access Journals (Sweden)

    Hannah Grant

    2017-01-01

    Full Text Available Introduction: Oral pre-exposure prophylaxis (PrEP is a promising new prevention approach for those most at risk of HIV infection. However, there are concerns that behavioural disinhibition, specifically reductions in condom use, might limit PrEP’s protective effect. This study uses the case of female sex workers (FSWs in Johannesburg, South Africa, to assess whether decreased levels of condom use following the introduction of PrEP may limit HIV risk reduction.Methods: We developed a static model of HIV risk and compared HIV-risk estimates before and after the introduction of PrEP to determine the maximum tolerated reductions in condom use with regular partners and clients for HIV risk not to change. The model incorporated the effects of increased STI exposure owing to decreased condom use. Noting that condom use with regular partners is generally low, we also estimated the change in condom use tolerated with clients only, to still achieve 50 and 90% risk reduction on PrEP. The model was parameterized using data from Hillbrow, Johannesburg. Sensitivity analyses were performed to ascertain the robustness of our results.Results: Reductions in condom use could be tolerated by FSWs with lower baseline condom use (65%. For scenarios where 75% PrEP effectiveness is attained, 50% HIV-risk reduction on PrEP would be possible even with 100% reduction in condom use from consistent condom use as high as 70% with clients. Increased exposure to STIs through reductions in condom use had limited effect on the reductions in condom use tolerated for HIV risk not to increase on PrEP.Conclusions: PrEP is likely to be of benefit in reducing HIV risk, even if reductions in condom use do occur. Efforts to promote consistent condom use will be critical for FSWs with high initial levels of condom use, but with challenges in adhering to PrEP.

  18. Comparing the impact of increasing condom use or HIV pre-exposure prophylaxis (PrEP use among female sex workers

    Directory of Open Access Journals (Sweden)

    Zindoga Mukandavire

    2016-03-01

    Full Text Available In many settings, interventions targeting female sex workers (FSWs could significantly reduce the overall transmission of HIV. To understand the role HIV pre-exposure prophylaxis (PrEP could play in controlling HIV transmission amongst FSWs, it is important to understand how its impact compares with scaling-up condom use—one of the proven HIV prevention strategies for FSWs. It is important to remember that condoms also have other benefits such as reducing the incidence of sexually transmitted infections and preventing pregnancy. A dynamic deterministic model of HIV transmission amongst FSWs, their clients and other male partners (termed ‘pimps’ was used to compare the protection provided by PrEP for HIV-negative FSWs with FSWs increasing their condom use with clients and/or pimps. For different HIV prevalence scenarios, levels of pimp interaction, and baseline condom use, we estimated the coverage of PrEP that gives the same reduction in endemic FSW HIV prevalence or HIV infections averted as different increases in condom use. To achieve the same impact on FSW HIV prevalence as increasing condom use by 1%, the coverage of PrEP has to increase by >2%. The relative impact of PrEP increases for scenarios where pimps contribute to HIV transmission, but not greatly, and decreases with higher baseline condom use. In terms of HIV infections averted over 10 years, the relative impact of PrEP compared to condoms was reduced, with a >3% increase in PrEP coverage achieving the same impact as a 1% increase in condom use. Condom promotion interventions should remain the mainstay HIV prevention strategy for FSWs, with PrEP only being implemented once condom interventions have been maximised or to fill prevention gaps where condoms cannot be used.

  19. Birthing Classes

    Science.gov (United States)

    ... first birth and hope to have a vaginal delivery this time, there is a class for that, too. Choose ... t covered in your birthing class, it’s a good idea to take an individual class on it, especially if you are a first-time mother. The health benefits of breastfeeding your baby ...

  20. PENN PASS: a program for graduates of foreign dental schools.

    Science.gov (United States)

    Berthold, P; Lopez, N

    1994-01-01

    An increasing number of graduates of foreign dental schools who enroll in advanced standing programs to qualify for licensure calls for dental schools to be prepared to handle not only the curricular demands but also the growing cultural diversity among its student population. The "reeducation" of this student group not only meets the need of foreign dentists for an American degree but may also provide health professionals to service various ethnic populations whose language and culture they are able to understand and identify with. A survey of students and graduates of a two-year Program for Advanced Standing Students (PASS) for graduates of foreign dental schools representing 34 countries aimed to arrive at an understanding of this student group through characterization of the foreign dentists and identification of their attitudes and feelings toward various aspects of the program, the school and faculty and their experience of stress. This report includes description of the distinctive features of the program which cater to specific needs and concerns of this non-traditional group of dental students. PASS students are accepted on the basis of their grades in dental school in home country, scores in the National Dental Board Examination Part I, Test of English as Foreign Language (TOEFL), and ratings in personal interviews. They complete an intensive summer program consisting of didactic and laboratory courses which prepares them for integration with four-year students for the last two years of didactic and clinical curriculum. Cultural diversity seminars, a special English class, PASS class meetings and seminars are unique additions to their program and aim to assist them adjust to the educational, social and cultural systems in an American school. Results of the survey show a majority of the PASS students feel that they are part of the school and that there is someone in the school whom they can approach for problems. An understanding of their ethnic and

  1. Efficient, Narrow-Pass-Band Optical Filters

    Science.gov (United States)

    Sandford, Stephen P.

    1996-01-01

    Optical filters with both narrow pass bands and high efficiencies fabricated to design specifications. Offer tremendous improvements in performance for number of optical (including infrared) systems. In fiber-optic and free-space communication systems, precise frequency discrimination afforded by narrow pass bands of filters provide higher channel capacities. In active and passive remote sensors like lidar and gas-filter-correlation radiometers, increased efficiencies afforded by filters enhance detection of small signals against large background noise. In addition, sizes, weights, and power requirements of many optical and infrared systems reduced by taking advantage of gains in signal-to-noise ratios delivered by filters.

  2. Contact conditions in skin-pass rolling

    DEFF Research Database (Denmark)

    Kijima, Hideo; Bay, Niels

    2007-01-01

    The special contact conditions in skin-pass rolling of steel strip is analysed by studying plane strain upsetting of thin sheet with low reduction applying long narrow tools and dry friction conditions. An extended sticking region is estimated by an elasto-plastic FEM analysis of the plane strain...... upsetting. This sticking region causes a highly inhomogeneous elasto-plastic deformation with large influence of work-hardening and friction. A numerical analysis of skin-pass rolling shows the same contact conditions, i.e. an extended sticking region around the center of the contact zone. The calculated...

  3. All Pass Network Based MSO Using OTRA

    Directory of Open Access Journals (Sweden)

    Rajeshwari Pandey

    2015-01-01

    Full Text Available This paper presents multiphase sinusoidal oscillators (MSOs using operational transresistance amplifier (OTRA based all pass networks. Both even and odd phase oscillations of equal amplitudes which are equally spaced in phase can be produced using single all pass section per phase. The proposed MSOs provide voltage output and can readily be used for driving voltage input circuits without increasing component count. The effect of nonideality of OTRA on the circuit performance is also analysed. The functionality of the proposed circuit is verified through PSPICE simulations.

  4. Willingness to use short-term oral pre-exposure prophylaxis (PrEP) by migrant miners and female partners of migrant miners in Mozambique.

    Science.gov (United States)

    Falcao, Joana; Ahoua, Laurence; Zerbe, Allison; di Mattei, Pietro; Baggaley, Rachel; Chivurre, Victor; Mulondo, Prince; Ramiro, Isaias; Dalal, Shona; Morales, Fernando; O'Reilly, Kevin; El-Sadr, Wafaa

    2017-05-04

    Migrant miners from Mozambique who work in South Africa and their partners are at substantial risk for HIV infection. We conducted a cross-sectional study to assess the willingness of migrant miners and female partners of miners to take short-term pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition. The study was conducted in Gaza Province, Mozambique, between September and October 2015. A total of 131 male miners and female partners of male miners completed a questionnaire. Subsequently, 48 in-depth interviews among male miners and female partners of miners and 3 focus-group discussions (6 participants each) among female partners of miners were conducted. Quantitative data were tabulated using Stata. A structured coding scheme was developed and qualitative data were analysed using Atlas.ti. Most participants (94%) were willing to take PrEP for short-term use. Facilitating factors for willingness to use PrEP were concerns about partner's sexual behaviour, desire for pregnancy and one's own sexual behaviour. The main barriers to PrEP use were concerns regarding side-effects, perceived difficulty adhering to daily pill taking and concern about partner/family disapproval. Overall, participants saw potential barriers for PrEP as minor obstacles that could be overcome. The male partner's influence on PrEP use was significant.

  5. The Impact of a Pass/Fail Option on Negotiation Course Performance.

    Science.gov (United States)

    Craver, Charles B.

    1998-01-01

    A law school professor analyzed data on pass/fail grading and conventional grading in his legal negotiation class over 11 years to determine statistically significant differences in performance of the two groups of students. Grades for both negotiation simulation exercises and written papers were analyzed. Results showed differences between the…

  6. 76 FR 9573 - Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P.; Notice of Application

    Science.gov (United States)

    2011-02-18

    ... Energy Regulatory Commission Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P.; Notice of Application Take notice that on January 31, 2011, Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P... (Liquefaction Project) at the existing Sabine Pass LNG Terminal, located in Cameron Parish, Louisiana....

  7. 33 CFR 401.31 - Meeting and passing.

    Science.gov (United States)

    2010-07-01

    ..., no vessel shall overtake and pass or attempt to overtake and pass another vessel— (1) In any canal; (2) Within 600 m of a canal or lock entrance; or (3) After the order of passing through has...

  8. Modeling drivers' passing duration and distance in a virtual environment

    Directory of Open Access Journals (Sweden)

    Haneen Farah

    2013-07-01

    The main contribution of this paper is in the empirical models developed for passing duration and distance which highlights the factors that affect drivers' passing behavior and can be used to enhance the passing models in simulation programs.

  9. Partial-prep bonded restorations in the anterior dentition: Long-term gingival health and predictability. A case report.

    Science.gov (United States)

    Molina, Ivan Contreras; Molina, Gil Contreras; Stanley, Kyle; Lago, Carlo; Xavier, Clessius Ferreira; Volpato, Claudia Angela Maziero

    2016-01-01

    Bonded porcelain restorations are a predictable and durable treatment option that can restore not only the strength and function of the teeth but also the esthetic appearance. One important issue in adhesive dentistry is the preservation of sound enamel. Following biomimetic principles, employing minimally invasive applications and adhesive technologies is of paramount importance for successful restorations. While it is widely accepted that minimally invasive restorative techniques should be favored, there is still some controversy over the noninvasive approaches. The purpose of this article is to question the complete "no-prep veneer" concept due to the possible negative effects on periodontal health caused by excessive contour and overhangs of the ceramic restoration, and to propose a new method to assess the quality and longevity of veneers with a partial-prep concept.

  10. Guide for the preparation of proposals for the Pre-Freshman Engineering Program: PREP-1981, (for minorities and women)

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The Pre-Freshman Engineering Program (PREP) for minorities and women (formerly PREFACE) will provide funds to colleges and universities for projects aimed at seeking out minority group individuals and women during junior high school and high school years (7th grade through the summer preceding matriculation in college) and providing them with enrichment experiences. Preparation and submission of proposals, evaluation and selection of proposals for support, and preparation of the final report are described.

  11. Generalizing Galileo's passé-dix game

    Science.gov (United States)

    Hombas, Vassilios

    2012-07-01

    This article shows a generalization of Galileo's 'passé-dix' game. The game was born following one of Galileo's [G. Galileo, Sopra le Scoperte dei Dadi (Galileo, Opere, Firenze, Barbera, Vol. 8). Translated by E.H. Thorne, 1898, pp. 591-594] explanations on a paradox that occurred in the experiment of tossing three fair 'six-sided' dice.

  12. The Physics of "String Passing through Ice"

    Science.gov (United States)

    Mohazzabi, Pirooz

    2011-01-01

    One of the oldest yet interesting experiments related to heat and thermodynamics is placing a string on a block of ice and hanging two masses from the ends of the string. Sometime later, it is discovered that the string has passed through the ice without cutting it in half. A simple explanation of this effect is that the pressure caused by the…

  13. Clandestine Message Passing in Virtual Environments

    Science.gov (United States)

    2008-09-01

    Steganography Hiding messages in pictures, audio , packets Place messages in clothing textures, object files Bots Automate the logic and control of...information will be developed along with proof of concepts. Visual cues, steganography and autonomous bots will be examined. Monitoring techniques are...14. SUBJECT TERMS Message Passing, Virtual Environments, Steganography , Second Life, Internet Terrorism, Honeyworld, Sun MPK20, Clandestine Messages

  14. PASS: Creating Physically Active School Systems

    Science.gov (United States)

    Ciotto, Carol M.; Fede, Marybeth H.

    2014-01-01

    PASS, a Physically Active School System, is a program by which school districts and schools utilize opportunities for school-based physical activity that enhance overall fitness and cognition, which can be broken down into four integral parts consisting of connecting, communicating, collaborating, and cooperating. There needs to be an…

  15. A characterization of attribute evaluation in passes

    NARCIS (Netherlands)

    Alblas, Henk

    1981-01-01

    This paper describes the evaluation of semantic attributes in a bounded number of passes from left-to-right and/or from right-to-left over the derivation tree of a program. Evaluation strategies where different instances of the same attribute in any derivation tree are restricted to be evaluated in

  16. Generalizing Galileo's Passe-Dix Game

    Science.gov (United States)

    Hombas, Vassilios

    2012-01-01

    This article shows a generalization of Galileo's "passe-dix" game. The game was born following one of Galileo's [G. Galileo, "Sopra le Scoperte dei Dadi" (Galileo, Opere, Firenze, Barbera, Vol. 8). Translated by E.H. Thorne, 1898, pp. 591-594] explanations on a paradox that occurred in the experiment of tossing three fair "six-sided" dice.…

  17. Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology

    DEFF Research Database (Denmark)

    Rozemeijer, Kirsten; Naber, Steffie K; Penning, Corine

    2017-01-01

    Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry...... of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 normal screening samples (23 833 123 person years).Exposure Use of SurePath or ThinPrep versus conventional cytology as screening test.Main outcome measure 72 month cumulative incidence...... was 58.5 (95% confidence interval 54.6 to 62.7) per 100 000 normal conventional cytology samples, compared with 66.8 (56.7 to 78.7) for ThinPrep and 44.6 (37.8 to 52.6) for SurePath. Compared with conventional cytology, the hazard of invasive cancer was 19% lower (hazard ratio 0.81, 95% confidence...

  18. The benefits of pass-fail grading on stress, mood, and group cohesion in medical students.

    Science.gov (United States)

    Rohe, Daniel E; Barrier, Patricia A; Clark, Matthew M; Cook, David A; Vickers, Kristin S; Decker, Paul A

    2006-11-01

    To objectively measure the effect of a pass-fail grading system on stress, mood, group cohesion, and test anxiety in medical students. Beginning with the class of 2006, the Mayo Medical School, Rochester, Minn, changed the grading system for first-year courses from a 5-interval grading system to a pass-fail grading system. Students in the previous class of 2005, who were graded using a 5-interval system during their first year of medical school, were compared with students in the class of 2006. Using a prospective study design, the 2 groups were compared at the end of both the first year and the second year of medical school on the Perceived Stress Scale, Profile of Mood States, Perceived Cohesion Scale, Test Anxiety Inventory, and (after year 2) the United States Medical Licensing Examination Step 1. Data collection occurred in 2002 and 2003 with the class of 2005 and in 2003 and 2004 with the class of 2006. Students graded with the pass-fail system had less perceived stress (median, 15.0 vs 21.0; P-.01) and greater group cohesion (median, 34.5 vs 30.0; P=.02) at the end of their second year of coursework than their 5-interval graded peers. The pass-fail group had better mood (median, 46.5) than the graded group (median, 64.0), but this difference was not statistically significant (P=.07). No significant differences were found between the 2 groups in test-taking anxiety or in United States Medical Licensing Examination Step 1 board scores. Pass-fail grading may reduce stress and increase group cohesion in medical students compared with traditional 5-interval grading.

  19. Willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in Malaysia: findings from a qualitative study.

    Science.gov (United States)

    Bourne, Adam; Cassolato, Matteo; Thuan Wei, Clayton Koh; Wang, Bangyuan; Pang, Joselyn; Lim, Sin How; Azwa, Iskandar; Yee, Ilias; Mburu, Gitau

    2017-08-02

    Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake. As part of a larger mixed-methods study exploring acceptability and willingness to use PrEP among MSM in Malaysia, 19 men took part in audio-recorded focus group discussions hosted by a community-based HIV organization and facilitated by a trained researcher. Discussions focussed on awareness and potential information management, general perceptions of PrEP and potential motivations or barriers to the use of PrEP, including those at the personal, social, health system or structural level. Data were transcribed verbatim and underwent a detailed thematic analysis. Rather than perceiving PrEP as a replacement for condoms in terms of having safer sex, many participants viewed it as an additional layer protection, serving as a crucial barrier to infection on occasions where condom use was intended, but did not occur. It was also perceived as more valuable to "at-risk" men, such as those in HIV sero-discordant relationships or those with a higher number of sexual partners. Elements of discussion tended to suggest that some men taking PrEP may be subject to stigma from others, on the assumption they may be promiscuous or engage in high-risk sexual behaviours. This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those

  20. CⅡEngineering Project Passed Completion Acceptance

    Institute of Scientific and Technical Information of China (English)

    LI; Zhen-yi; LI; Song; XUE; Sui-zhi; LI; Yan; CHENG; Ming

    2013-01-01

    CⅡengineering project involves the design and technical services of a reactor electric power supply system,which responds to the requirement of foreign client.The content of this project mainly covers three aspects including Class 1E Low Voltage AC System,Class 1E Low Voltage DC System,

  1. Quantitative Detection of Screening for Cervical Lesions with ThinPrep Cytology Test

    Institute of Scientific and Technical Information of China (English)

    Hong-xin ZHANG; Yi-min SONG; Su-hong LI; Yu-hui YIN; Dong-ling GAO; Kui-sheng CHEN

    2010-01-01

    OBJECTIVE To investigate the available parameters in gynecological screening for cervical lesions by liquid-based cytology technology (ThinPrep Cytology Test, TCT) and The Bethesda System (TBS), also with computer image analysis. METHODS With application of the image analysis system, all grades of cervical lesion cells were detected quantitatively and sorted in atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells-cannot exclude HSIL (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma (SCC) with the mean optical density (MOD), average grey (AG), positive units (PU), and nucleus to cytoplasmic ratio (N:C). Differences between each group of cells were compared and analyzed statistically.RESULTS Apart from four stereologic parameters in LSIL and HSIL groups there were no differences among them, in the other groups, there was statistically significant in differences between MOD, AG and PU values. Differences between them in the ratio of nucleus to cytoplasm were highly statistically signifi cant. CONCLUSION Stereological indexes may serve as a screening tool for cervical lesions. The image analysis system is expected to become a new means of cytological assisted diagnosis.

  2. Morphologic features of prostatic adenocarcinoma on ThinPrep® urinary cytology.

    Science.gov (United States)

    Tyler, Kevin L; Selvaggi, Suzanne M

    2011-02-01

    Malignant cells of prostatic adenocarcinoma are rarely identified in urine. In most cases, this finding is associated with high stage tumor. Numerous descriptions of the morphology of prostatic adenocarcinoma have been reported using cytocentrifugated specimens. However, no specific morphologic description of prostatic adenocarcinoma in urine using liquid-based cytology has been previously described. Four cases of prostatic adenocarcinoma in urine using ThinPrep® liquid-based preparations were identified between 2002 and 2009 at the University of Wisconsin Hospital and Clinics. Three patients had either high stage tumor or metastatic disease at the time of diagnosis, while the remaining patient had low stage tumor. The morphology of each case was evaluated with specific attention to cell size, nuclear characteristics, nuclear to cytoplasmic ratio, and cytoplasmic characteristics. The resulting key features for prostatic adenocarcinoma in urine are clustering, increased nuclear to cytoplasmic ratio, and prominent nucleoli. Though typically the presence of prostatic adenocarcinoma in urine implies high stage tumor, cells of lower stage tumors may be seen in urine as well.

  3. HyperPASS, a New Aeroassist Tool

    Science.gov (United States)

    Gates, Kristin; McRonald, Angus; Nock, Kerry

    2005-01-01

    A new software tool designed to perform aeroassist studies has been developed by Global Aerospace Corporation (GAC). The Hypersonic Planetary Aeroassist Simulation System (HyperPASS) [1] enables users to perform guided aerocapture, guided ballute aerocapture, aerobraking, orbit decay, or unguided entry simulations at any of six target bodies (Venus, Earth, Mars, Jupiter, Titan, or Neptune). HyperPASS is currently being used for trade studies to investigate (1) aerocapture performance with alternate aeroshell types, varying flight path angle and entry velocity, different gload and heating limits, and angle of attack and angle of bank variations; (2) variable, attached ballute geometry; (3) railgun launched projectile trajectories, and (4) preliminary orbit decay evolution. After completing a simulation, there are numerous visualization options in which data can be plotted, saved, or exported to various formats. Several analysis examples will be described.

  4. UN-aided Project Passing Final Assessment

    Institute of Scientific and Technical Information of China (English)

    Wang Anfang

    1995-01-01

    @@ A number of projects funded by the United Nations Development Program passed final examination and assessment in April 1994.They are the well-completion technical center project of the Southwest Petroleum Institute with a fund of 1.27 million US dollars and the acidizing and fracturing technical service center of Wanzhuang Branch Research Institute of Petroleum Exploration and Development (RIPED) with a fund of 1.41 million US dollars.

  5. Low Pass Filters with Linear Phase.

    Science.gov (United States)

    1985-12-12

    DISCUSSION OF RESULTS............................... 35 LIST OF ILLUSTRATIONS Figure page 1. Template applicable to single stage linear phase filter .................. 2...technology suggests examination of the low-pass lin- ear phase filter as a means of prefiltering such data before, or concurrently with, sam- pling. Today, a...stage low passlinear phase filter . Here, M is the number of "main poles". A linear phase design alsorequires a minimum overhead of two "corrector poles

  6. Price pass-through and minimum wages

    OpenAIRE

    Daniel Aaronson

    1997-01-01

    A textbook consequence of competitive markets is that an industry-wide increase in the price of inputs will be passed on to consumers through an increase in prices. This fundamental implication has been explored by researchers interested in who bears the burden of taxation and exchange rate fluctuations. However, little attention has focused on the price implications of minimum wage hikes. From a policy perspective, this is an oversight. Welfare analysis of minimum wage laws should not ignore...

  7. 30 CFR 57.19018 - Overtravel by-pass switches.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Overtravel by-pass switches. 57.19018 Section... Hoisting Hoists § 57.19018 Overtravel by-pass switches. When an overtravel by-pass switch is installed, the... switch is held in the closed position by the hoistman. The overtravel by-pass switch shall...

  8. 30 CFR 56.19018 - Overtravel by-pass switches.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Overtravel by-pass switches. 56.19018 Section... Hoisting Hoists § 56.19018 Overtravel by-pass switches. When an overtravel by-pass switch is installed, the... switch is held in the closed position by the hoistman. The overtravel by-pass switch shall...

  9. 20 CFR 416.2099 - Compliance with pass-along.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Compliance with pass-along. 416.2099 Section... pass-along. (a) Information regarding compliance. Any State required to enter into a pass-along... Commissioner's satisfaction that the State is meeting the pass-along requirements. The information...

  10. Effect of Ball Mass on Dribble, Pass, and Pass Reception in 9-11-Year-Old Boys' Basketball

    Science.gov (United States)

    Arias, Jose L.; Argudo, Francisco M.; Alonso, Jose I.

    2012-01-01

    The objective of the study was to analyze the effect of ball mass on dribble, pass, and pass reception in real game situations in 9-11-year-old boys' basketball. Participants were 54 boys identified from six federated teams. The independent variable was ball mass, and dependent variables were number of dribbles, passes, and pass receptions. Three…

  11. 78 FR 1851 - Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P.; Notice of Intent To Prepare an...

    Science.gov (United States)

    2013-01-09

    ... Energy Regulatory Commission Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Proposed Sabine Pass Liquefaction Modification Project and... impacts of the Sabine Pass Liquefaction Modification Project (Project) involving the modification...

  12. 75 FR 68347 - Sabine Pass Liquefaction LLC, and Sabine Pass LNG, L.P.; Notice of Intent To Prepare an...

    Science.gov (United States)

    2010-11-05

    ... Energy Regulatory Commission Sabine Pass Liquefaction LLC, and Sabine Pass LNG, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned Sabine Pass Liquefaction Project and Request for... impacts of the Sabine Pass Liquefaction Project (Project) involving construction and operation...

  13. Word classes

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2007-01-01

    This article provides an overview of recent literature and research on word classes, focusing in particular on typological approaches to word classification. The cross-linguistic classification of word class systems (or parts-of-speech systems) presented in this article is based on statements found...... a parts-of-speech system that includes the categories Verb, Noun, Adjective and Adverb, other languages may use only a subset of these four lexical categories. Furthermore, quite a few languages have a major word class whose members cannot be classified in terms of the categories Verb – Noun – Adjective...

  14. Polymorphic Endpoint Types for Copyless Message Passing

    Directory of Open Access Journals (Sweden)

    Viviana Bono

    2011-07-01

    Full Text Available We present PolySing#, a calculus that models process interaction based on copyless message passing, in the style of Singularity OS. We equip the calculus with a type system that accommodates polymorphic endpoint types, which are a variant of polymorphic session types, and we show that well-typed processes are free from faults, leaks, and communication errors. The type system is essentially linear, although linearity alone may leave room for scenarios where well-typed processes leak memory. We identify a condition on endpoint types that prevents these leaks from occurring.

  15. Electronically Tunable Fractional Order All Pass Filter

    Science.gov (United States)

    Verma, Rakesh; Pandey, Neeta; Pandey, Rajeshwari

    2017-08-01

    In this paper, an electronically tunable fractional order all pass filter (FOAPF) based on operational transconductance amplifier (OTA) is presented. It uses two OTAs and single fractional order capacitor (FC) of non-integer order α to provide FOAPF of α order. Two different values of α, in particular 0.5 and 0.9, for FC are taken for investigation. The functionality of the proposal is verified through SPICE simulations using TSMC 0.18 μm Complementary Metal Oxide Semiconductor (CMOS) process parameters. Simulated and theoretical frequency and time domain responses are found to be in close agreement.

  16. Compressive Imaging via Approximate Message Passing

    Science.gov (United States)

    2015-09-04

    20] uses an adaptive Wiener filter [21] for 2D denoising. Another option is to use a more sophisticated image 2D denoiser such as BM3D [22] within AMP... filtering ,” IEEE Trans. Image Process ., vol. 16, no. 8, pp. 2080–2095, Aug. 2007. [23] J. Tan, Y. Ma, H. Rueda, D. Baron, and G. Arce, “Application of...JOURNAL OF SELECTED TOPICS IN in Signal Processing , (06 2015): 1. doi: Jin Tan, Yanting Ma, Dror Baron. Compressive Imaging via Approximate MessagePassing

  17. An experimental evaluation of multi-pass solar air heaters

    Energy Technology Data Exchange (ETDEWEB)

    Satcunanathan, S.; Persad, P.

    1980-12-01

    Three collectors of identical dimensions but operating in the single-pass, two-pass and three-pass modes were tested simultaneously under ambient conditions. It was found that the two-pass air heater was consistently better than the single-pass air heater over the day for the range of mass flow rates considered. It was also found that at a mass flow rate of 0.0095 kg s/sup -1/ m/sup -2/, the thermal performances of the two-pass and three-pass collectors were identical, but at higher flow rates the two-pass collector was superior to the three-pass collector, the superiority decreasing with increasing mass flow rate.

  18. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... bias from omitted variables, the preferred IV results indicate considerable negative effects due to larger class sizes and larger numbers of overage-for-grade peers. The latter, driven by the highly prevalent practices of grade repetition and academic redshirting, should be considered an important...

  19. ABM Drag_Pass Report Generator

    Science.gov (United States)

    Fisher, Forest; Gladden, Roy; Khanampornpan, Teerapat

    2008-01-01

    dragREPORT software was developed in parallel with abmREPORT, which is described in the preceding article. Both programs were built on the capabilities created during that process. This tool generates a drag_pass report that summarizes vital information from the MRO aerobreaking drag_pass build process to facilitate both sequence reviews and provide a high-level summarization of the sequence for mission management. The script extracts information from the ENV, SSF, FRF, SCMFmax, and OPTG files, presenting them in a single, easy-to-check report providing the majority of parameters needed for cross check and verification as part of the sequence review process. Prior to dragReport, all the needed information was spread across a number of different files, each in a different format. This software is a Perl script that extracts vital summarization information and build-process details from a number of source files into a single, concise report format used to aid the MPST sequence review process and to provide a high-level summarization of the sequence for mission management reference. This software could be adapted for future aerobraking missions to provide similar reports, review and summarization information.

  20. PASSING STANDARDIZED ASSESSMENTS WITH FADING PROMPTS

    Directory of Open Access Journals (Sweden)

    Amy Marie GREENE

    2015-11-01

    Full Text Available Introduction: No Child Left Behind Act of 2001 mandates that all students perform at a level of proficient on state assessments. This includes students with learning and intellectual disabilities who are inherently performing below grade level. Given that schools are held accountable for meeting these goals and some states are not allowing students to graduate if they do not pass the assessments, this is a large concern for students, parents, teachers, and administration Method: Forty-five students with a disability in writing or an intellectual disability participated in this quasi-experimental, single-group, pretest-posttest design that evaluated the effectiveness of the Fading Prompts through Graphic Organizers method for students with learning and intellectual disabilities in written expression as measured according to the Pennsylvania System of School Assessment. Results: Data analyses were conducted through the use of four dichotomies for percent differences, which compared teacher administered pretests and posttests, pretests and the state administered PSSA, teacher administered posttests and the PSSA, and the participants’ PSSA and the average state PSSA score. All forty-five students performed at a below basic level during baseline and a proficient level on the posttest. The learned skills generalized to the PSSA with forty-three students earning a passing score of proficient, while two students advanced to basic. Conclusion: Based on the outcomes of this study, it is highly recommended that this program be utilized at least for students with learning and intellectual disabilities until further research can be done.

  1. The effects of a prenatal course including PREP for effective family living on self-esteem and parenting attitudes of adolescents: a brief report.

    Science.gov (United States)

    Emmons, R D; Nystul, M S

    1994-01-01

    Nine adolescent females were enrolled in a prenatal course that included the PREP for Effective Family Living Program (the treatment group). Two comparison groups were utilized in this study; one attended the prenatal group without the PREP program, and the second did not attend either the prenatal course or the PREP program. The Coopersmith Self-Esteem Inventory and the Attitude Toward the Freedom of Children Scale (a parental attitude scale) was administered to all participants. No significant difference was found among the three groups in terms of self-concept. A significant difference was found among the three groups in terms of parental attitudes, with the treatment group scoring higher on democratic parenting attitudes than did the two comparison groups.

  2. Chem-Prep PZT 95/5 for neutron generator applications : development of laboratory-scale powder processing operations.

    Energy Technology Data Exchange (ETDEWEB)

    Montoya, Ted V.; Moore, Roger Howard; Spindle, Thomas Lewis Jr.

    2003-12-01

    Chemical synthesis methods are being developed as a future source of PZT 95/5 powder for neutron generator voltage bar applications. Laboratory-scale powder processes were established to produce PZT billets from these powders. The interactions between calcining temperature, sintering temperature, and pore former content were studied to identify the conditions necessary to produce PZT billets of the desired density and grain size. Several binder systems and pressing aids were evaluated for producing uniform sintered billets with low open porosity. The development of these processes supported the powder synthesis efforts and enabled comparisons between different chem-prep routes.

  3. OligoPrep PVA support for oligonucleotide synthesis in columns on a scale up to 10 micromol.

    Science.gov (United States)

    Aitken, Sheena; Anderson, Emma

    2007-01-01

    OligoPrep is a macroporous polyvinylacetate (PVA) biodegradable support that has been designed for cost-effective automated synthesis of oligonucleotides using standard phosphoramidite chemistry. Originally developed for large-scale oligonucleotide synthesis in beds and reactors, we present here its utility for medium-scale work of 1-10 micromol in column syntheses on standard DNA synthesizers. We show how an increase in scale, and, therefore, yield, can be achieved without significant increase in reagent quantity. Additional deblock and oxidation cycles can provide high coupling yields, and the use of concentrated ammonia in aqueous methylamine (AMA) for oligonucleotide cleavage and deprotection results in excellent recovery.

  4. Efectos de una dosis baja de bisfenol A sobre el eje reproductor de ratas machos prepúberes

    OpenAIRE

    Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Ponzo, Osvaldo Juan; Carbone, Silvia Elena; Pandolfi, Matias; Scacchi, Pablo; Reynoso, Roxana María

    2015-01-01

    El objetivo del presente trabajo fue estudiar el efecto de una dosis baja de bisfenol A (BPA) sobre el eje reproductor de ratas macho prepúberes, expuestas durante la gestación y la lactancia. Se trató a ratas hembra preñadas con una dosis aproximada de exposición de BPA de 3 mg, administrado en el agua de bebida, y el tratamiento continuó durante la lactancia. Las crías macho fueron sacrificadas a los 35 días de vida, etapa prepuberal. Se evaluó el peso corporal durante el desarrollo de las...

  5. "I did not want to give birth to a child who has HIV": Experiences using PrEP during pregnancy among HIV-uninfected Kenyan women in HIV-serodiscordant couples.

    Science.gov (United States)

    Pintye, Jillian; Beima-Sofie, Kristin M; Kimemia, Grace; Ngure, Kenneth; Trinidad, Susan Brown; Heffron, Renee; Baeten, Jared; Odoyo, Josephine; Mugo, Nelly; Bukusi, Elizabeth A; Kelley, Maureen C; John-Stewart, Grace C

    2017-07-31

    The perceptions, motivations, and beliefs of HIV-uninfected women about PrEP use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. Semi-structured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy. Interviews were audio-recorded and transcribed into English. A qualitative descriptive analysis was performed, using a constant comparison approach to identify key themes related to PrEP use in pregnancy. Desire to remain HIV-uninfected and have an HIV-free infant were strong motivators influencing continued use of PrEP during pregnancy. Supporting HIV-infected partners and childbearing within an HIV-serodiscordant relationship were also motivators. Women had challenges distinguishing normal pregnancy symptoms from PrEP side effects and were concerned that observed side effects could be signs of danger for the infant related to PrEP exposure. Healthcare providers were important conduits of knowledge about PrEP, and continuity of PrEP providers throughout pregnancy facilitated adherence. HIV-uninfected women in HIV-serodiscordant couples were motivated to use PrEP during pregnancy to remain HIV-uninfected and to have an HIV-free child, but had concerns about side effects. Healthcare providers will be important for PrEP messaging and adherence support in this unique population.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without

  6. Intimate Partner Violence and Adherence to HIV Pre-exposure Prophylaxis (PrEP) in African Women in HIV Serodiscordant Relationships: A Prospective Cohort Study.

    Science.gov (United States)

    Roberts, Sarah T; Haberer, Jessica; Celum, Connie; Mugo, Nelly; Ware, Norma C; Cohen, Craig R; Tappero, Jordan W; Kiarie, James; Ronald, Allan; Mujugira, Andrew; Tumwesigye, Elioda; Were, Edwin; Irungu, Elizabeth; Baeten, Jared M

    2016-11-01

    Intimate partner violence (IPV) is associated with higher HIV incidence, reduced condom use, and poor adherence to antiretroviral therapy and other medications. IPV may also affect adherence to pre-exposure prophylaxis (PrEP). We analyzed data from 1785 HIV-uninfected women enrolled in a clinical trial of PrEP among African HIV serodiscordant couples. Experience of verbal, physical, or economic IPV was assessed at monthly visits by face-to-face interviews. Low PrEP adherence was defined as clinic-based pill count coverage <80% or plasma tenofovir levels <40 ng/mL. The association between IPV and low adherence was analyzed using generalized estimating equations, adjusting for potential confounders. In-depth interview transcripts were examined to explain how IPV could impact adherence. Sixteen percent of women reported IPV during a median of 34.8 months of follow-up (interquartile range 27.0-35.0). Overall, 7% of visits had pill count coverage <80%, and 32% had plasma tenofovir <40 ng/mL. Women reporting IPV in the past 3 months had increased risk of low adherence by pill count (adjusted risk ratio 1.49, 95% confidence interval: 1.17 to 1.89) and by plasma tenofovir (adjusted risk ratio 1.51, 95% confidence interval: 1.06 to 2.15). Verbal, economic, and physical IPV were all associated with low adherence. However, the impact of IPV diminished and was not statistically significant 3 months after the reported exposure. In qualitative interviews, women identified several ways in which IPV affected adherence, including stress and forgetting, leaving home without pills, and partners throwing pills away. Women who reported recent IPV in the Partners PrEP Study were at increased risk of low PrEP adherence. Strategies to mitigate PrEP nonadherence in the context of IPV should be evaluated.

  7. A Multifunction Filter for Realizing Gain Variable Low-Pass and Band-Pass Responses

    Directory of Open Access Journals (Sweden)

    Halil ALPASLAN

    2010-02-01

    Full Text Available The second generation current conveyors (CCIIs as active circuit devices are widely used for designing current-mode (CM filters. In this paper, a single input multi output filter employing only plus-type CCIIs (CCII+s and grounded capacitors, and for providing variable gain low-pass and band-pass responses, is suggested. The proposed filter is free from critical passive component matching conditions. Therefore, it is suitable for integrated circuit (IC technology. Further, developed filter configuration can be easily realized with commercially available active devices such as AD844s. The circuit performance is demonstrated by means of SPICE simulation and experimental test results.

  8. Do College-Prep Programs Improve Long-Term Outcomes? NBER Working Paper No. 17859

    Science.gov (United States)

    Jackson, C. Kirabo

    2012-01-01

    I analyze the longer-run effects of a college-preparatory program implemented in inner-city schools that included payments to eleventh- and twelfth- grade students and their teachers for passing scores on Advanced Placement exams. Affected students attended college in greater numbers, were more likely to remain in college beyond their first year,…

  9. The Cobas AmpliPrep/Cobas TaqMan HCV Test, Version 2.0, Real-Time PCR Assay Accurately Quantifies Hepatitis C Virus Genotype 4 RNA

    OpenAIRE

    Chevaliez, Stéphane; Bouvier-Alias, Magali; Rodriguez, Christophe; Soulier, Alexandre; Poveda, Jean-Dominique; Pawlotsky, Jean-Michel

    2013-01-01

    Accurate hepatitis C virus (HCV) RNA quantification is mandatory for the management of chronic hepatitis C therapy. The first-generation Cobas AmpliPrep/Cobas TaqMan HCV test (CAP/CTM HCV) underestimated HCV RNA levels by >1-log10 international units/ml in a number of patients infected with HCV genotype 4 and occasionally failed to detect it. The aim of this study was to evaluate the ability of the Cobas AmpliPrep/Cobas TaqMan HCV test, version 2.0 (CAP/CTM HCV v2.0), to accurately quantify H...

  10. Zika May Be Passed on Through Tears, Sweat: Report

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161204.html Zika May Be Passed on Through Tears, Sweat: Report ... 2016 WEDNESDAY, Sept. 28, 2016 (HealthDay News) -- The Zika virus might be able to pass from person ...

  11. Enhanced transmittance of a dual pass-band metamaterial filter

    Science.gov (United States)

    Wang, XiaoZhi; Zhu, Honghui; Liu, Zhigang

    2017-03-01

    A broad pass-band metamaterial-based optical filter is experimentally and numerically studied. The designed structure consists of periodically arranged composite metallic arrays and dielectric layer that exhibits transmission responses composed of two flat pass-bands. The coupling of localized surface plasmon (LSP) modes results in the low-frequency pass-band, while the internal surface plasmon polaritons (ISPPs) between the upper and lower metal layers leads to the high-frequency pass-band. Structural parameters (L and R) are experimentally considered from the viewpoint of exploiting their effects on the pass-bands and resonance frequencies. The bandwidths of these pass-bands both can reach to maximums by optimization of these structural parameters. In addition, the two pass-bands can be modulated to be a single pass-band with a bandwidth of 10.7 THz by optimizing L and R simultaneously.

  12. The baton passes to the LHC

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Held in the picturesque mountain setting of La Thuile in the Italian Alps, the international conference “Rencontres de Moriond” showed how the baton of discovery in the field of high-energy physics is definitely passing to the LHC experiments. In the well-known spirit of Moriond, the conference was an important platform for young students to present their latest results. The Higgs boson might well be within reach this year and the jet-quenching phenomenon might reveal new things soon…   New physics discussed over the Italian Alps during the "Les rencontres de Moriond" conference.  (Photographer: Paul Gerritsen. Adapted by Katarina Anthony) Known by physicists as one of the most important winter conferences, “Les rencontres de Moriond” are actually a series of conferences spread over two weeks covering the main themes of electroweak interactions, QCD and high-energy interactions, cosmology, gravitation, astropar...

  13. The Pension Fund passes important milestones

    CERN Multimedia

    2012-01-01

    In this column, the Chairman of the Pension Fund Governing Board (PFGB) presents the Board's latest main decisions, initiatives and accomplishments to the Fund's members and beneficiaries.   Since my last report in October, the PFGB has passed several milestones in actuarial, technical and investment matters. The PFGB has completed an analysis of a request by the European Organisation for Astronomical Research in the Southern Hemisphere (ESO) to reduce the increased cost of pension insurance for new ESO recruits that has been caused by the increased CHF/€ exchange ratio. Currently the staff of ESO are admitted to the CERN Pension Fund, pursuant to a co-operation agreement between CERN and ESO dating back to 1968. This analysis assessed the actuarial, financial, administrative and legal implications, and is scheduled to be presented to the CERN Council and the Finance Committee in December. After an open tendering process the PFGB has selected Buck Consultants Limited...

  14. Message Passing for Dynamic Network Energy Management

    CERN Document Server

    Kraning, Matt; Lavaei, Javad; Boyd, Stephen

    2012-01-01

    We consider a network of devices, such as generators, fixed loads, deferrable loads, and storage devices, each with its own dynamic constraints and objective, connected by lossy capacitated lines. The problem is to minimize the total network objective subject to the device and line constraints, over a given time horizon. This is a large optimization problem, with variables for consumption or generation in each time period for each device. In this paper we develop a decentralized method for solving this problem. The method is iterative: At each step, each device exchanges simple messages with its neighbors in the network and then solves its own optimization problem, minimizing its own objective function, augmented by a term determined by the messages it has received. We show that this message passing method converges to a solution when the device objective and constraints are convex. The method is completely decentralized, and needs no global coordination other than synchronizing iterations; the problems to be...

  15. L'avenir au passé

    Directory of Open Access Journals (Sweden)

    Lionel Acher

    2000-05-01

    Full Text Available Il n'y a, bien évidemment, aucun mérite dans un roman historique à faire prédire par un personnage ou par le narrateur lui-même quels seront les événements du futur. Ce type de roman étant, par définition, consacré à la narration d'une intrigue située dans le passé et à la recons­titution d'une époque révolue (quelquefois, comme c'est le cas dans notre corpus de romans, depuis près de vingt siècles, point n'est besoin d'être grand clerc pour annoncer un avenir que l'historiographie a ampleme...

  16. An Active Tracking Band-Pass Filter,

    Science.gov (United States)

    1985-05-01

    Cette boucle comporte un amplificateur i commande automatique de gain et un convertisseur de fr~quence A tension rapides ainsi qu’un filtre passe-bas...attenuates the DC voltage and low-frequency fluctuations that accompany the output. 3.4 Frequency-to-Voltage Converter and Voltage Adaptor The output of the...m 0..’C X dC ., m o) ICU...C X CC. a,.. a V1 CCr.4 CC - CC 4 0 0 oC w4 rCC 6~..I 0 =1I .X C .C 0 C cC ’ C.C E.0 0 C o z .oo. o o .V o r C0 CC w0I vr 0

  17. 34 CFR 300.190 - By-pass-general.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false By-pass-general. 300.190 Section 300.190 Education... DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.190 By-pass—general. (a) If, on... Secretary implements a by-pass. (Authority: 20 U.S.C. 1412(f)(1))...

  18. 75 FR 62690 - Radio Broadcasting Services; Grants Pass, Oregon

    Science.gov (United States)

    2010-10-13

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Grants Pass, Oregon AGENCY: Federal Communications..., allots FM Channel 257A at Grants Pass, Oregon, as the community's second commercial FM transmission service. Channel 257A can be allotted at Grants Pass, consistent with the minimum distance...

  19. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2001-01-01

    We present a new transformation of λ-terms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Previous CPS transformations only enjoyed two out of the three properties of being first-order, one-pass, and compositional...

  20. 47 CFR 7.9 - Information pass through.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Information pass through. 7.9 Section 7.9... EQUIPMENT BY PEOPLE WITH DISABILITIES Obligations-What Must Covered Entities Do? § 7.9 Information pass through. Telecommunications equipment and customer premises equipment shall pass through...

  1. 47 CFR 6.9 - Information pass through.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Information pass through. 6.9 Section 6.9... Entities Do? § 6.9 Information pass through. Telecommunications equipment and customer premises equipment shall pass through cross-manufacturer, non-proprietary, industry-standard codes, translation...

  2. 75 FR 43897 - FM TABLE OF ALLOTMENTS, GRANTS PASS, OREGON

    Science.gov (United States)

    2010-07-27

    ... COMMISSION 47 CFR Part 73 FM TABLE OF ALLOTMENTS, GRANTS PASS, OREGON AGENCY: Federal Communications... the allotment of FM Channel 257A as the second commercial allotment at Grants Pass, Oregon. The channel can be allotted at Grants Pass in compliance with the Commission's minimum distance...

  3. 78 FR 18479 - Drawbridge Operation Regulations; Pass Manchac, LA

    Science.gov (United States)

    2013-03-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Pass Manchac, LA AGENCY: Coast Guard... automated bascule span drawbridge across Pass Manchac, mile 6.7, at Manchac, between St. John and Tangipahoa... Pass Manchac, mile 6.7, at Manchac, between St. John and Tangipahoa Parishes, Louisiana. The bridge...

  4. 20 CFR 631.18 - Federal by-pass authority.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Federal by-pass authority. 631.18 Section 631... Procedures § 631.18 Federal by-pass authority. (a) In the event that a State fails to submit a biennial State... Secretary's intent to exercise by-pass authority and an opportunity to request and to receive a...

  5. 48 CFR 652.237-71 - Identification/Building Pass.

    Science.gov (United States)

    2010-10-01

    ... Pass. 652.237-71 Section 652.237-71 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES... Identification/Building Pass. As prescribed in 637.110(b), insert the following clause. Identification/Building Pass (APR 2004) (a) Contractors working in domestic facilities who already possess a security...

  6. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2002-01-01

    We present a new transformation of call-by-value lambdaterms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Because it operates in one pass, it directly yields compact CPS programs that are comparable to what one would...

  7. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2003-01-01

    We present a new transformation of λ-terms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Previous CPS transformations only enjoyed two out of the three properties of being first-order, one-pass, and compositional...

  8. Ningwu——An Ancient Pass On The Plateau

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Ningwu situated on the Loess Plateau in north of Shanxi Province is one of the three passes along the Great Wall. The other two are the Pian Pass in the west and the Yanmen Pass in the east. In the ancient times, it had been a key military town in the northern Chinese borders.

  9. 36 CFR 1193.37 - Information pass through.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Information pass through... § 1193.37 Information pass through. Telecommunications equipment and customer premises equipment shall pass through cross-manufacturer, non-proprietary, industry-standard codes, translation...

  10. Percentage recovery of dioxin homologue through power-prep according to the eluting solvents and their amounts

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Tae-Uk [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science]|[National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Kim, Dong-Gyu [National Veterinary Research and Quarantine Service (Korea). Seoul Regional Office; Choi, Si-Weon [National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Seo, Dong-Cheol; Jeo, Jong-Soo [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science; Lee, Hong-Jae [Jinju National Univ. (Korea). Dept. of Environmental Engineering

    2004-09-15

    Because of the persistence and accumulation of polychlorinated dibenzo dioxins(PCDDs) and polychlorinated dibenzo furans(PCDFs) in the environment, dioxins contamination is regarded as a global issue. And various methods for analyzing PCDDs and PCDFs have been developed and improved. According to US EPA method, cleanup method was very various. Conventional cleanup methods are very dependable, but are time consuming and use large volumes of organic solvents. To increase the efficiency of cleanup for the analysis of PCDDs and PCDFs, we used high speed automated sample cleanup system for dioxins which is called Power-Prep trademark (Fluid Management System Inc., USA). Power- Prep trademark gave us swift analysis of dioxin and its precision and accuracy. This system was designed to cleanup of toxic compound such as dioxins, PCBs, pesticides and PAHs using silica, alumina and carbon column. Using this system, it is possible to conduct several samples in less than 1.5 hours, thereby, achieving high recoveries and excellent precision and accuracy for all dioxin congeners. In this experiment, we carried out PCDDs and PCDFs analysis by FMS(Fluid Management System Inc.) with 3 eluting solvents such as toluene, hexane and dichloromethane to find out the best eluting solvent and its amounts.

  11. The Poetry Asks for Passing... at School

    Directory of Open Access Journals (Sweden)

    Esméria de Lourdes Saveli

    2007-06-01

    Full Text Available The article presents the results of a research about the space that the poetry occupies in the school context. It was verified the frequency that the poetical texts are worked, their receptivity among the pupils, the type of activities teachers propose, the difficulties found by them and the conditions offered by the school for the development of these activities. It searched, still, to identify the students’ preference in relation to the authors which are presented by the teachers in their classes. The data was gotten by a questionnaire, with half-structuralized questions related to the teachers practicing with the poetical text. This questionnaire was applied, in 2005, in six State schools, in Ponta Grossa, PR. It evidenced that the poetry occupies a shy place in the didactic books that have been the pedagogical support in the Portuguese Language classes and, as a result, it is not much present in the classroom.

  12. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... outcomes. This study uses new microdata from East Africa, incorporating test score data for over 250,000 children, to compare the likely efficacy of these two types of interventions. Endogeneity bias is addressed via fixed effects and instrumental variables techniques. Although these may not fully mitigate...

  13. Nanomechanical characterization by double-pass force-distance mapping

    Energy Technology Data Exchange (ETDEWEB)

    Dagdas, Yavuz S; Tekinay, Ayse B; Guler, Mustafa O; Dana, Aykutlu [UNAM Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara (Turkey); Necip Aslan, M, E-mail: aykutlu@unam.bilkent.edu.tr [Department of Physics, Istanbul Technical University, Istanbul (Turkey)

    2011-07-22

    We demonstrate high speed force-distance mapping using a double-pass scheme. The topography is measured in tapping mode in the first pass and this information is used in the second pass to move the tip over the sample. In the second pass, the cantilever dither signal is turned off and the sample is vibrated. Rapid (few kHz frequency) force-distance curves can be recorded with small peak interaction force, and can be processed into an image. Such a double-pass measurement eliminates the need for feedback during force-distance measurements. The method is demonstrated on self-assembled peptidic nanofibers.

  14. Astor Pass Seismic Surveys Preliminary Report

    Energy Technology Data Exchange (ETDEWEB)

    Louie, John [UNR; Pullammanappallil, Satish [Optim; Faulds, James; Eisses, Amy; Kell, Annie; Frary, Roxanna; Kent, Graham

    2011-08-05

    In collaboration with the Pyramid Lake Paiute Tribe (PLPT), the University of Nevada, Reno (UNR) and Optim re-processed, or collected and processed, over 24 miles of 2d seismic-reflection data near the northwest corner of Pyramid Lake, Nevada. The network of 2d land surveys achieved a near-3d density at the Astor Pass geothermal prospect that the PLPT drilled during Nov. 2010 to Feb. 2011. The Bureau of Indian Affairs funded additional seismic work around the Lake, and an extensive, detailed single-channel marine survey producing more than 300 miles of section, imaging more than 120 ft below the Lake bottom. Optim’s land data collection utilized multiple heavy vibrators and recorded over 200 channels live, providing a state-of-the-art reflection-refraction data set. After advanced seismic analysis including first-arrival velocity optimization and prestack depth migration, the 2d sections show clear fault-plane reflections, in some areas as deep as 4000 ft, tying to distinct terminations of the mostly volcanic stratigraphy. Some lines achieved velocity control to 3000 ft depth; all lines show reflections and terminations to 5000 ft depth. Three separate sets of normal faults appear in an initial interpretation of fault reflections and stratigraphic terminations, after loading the data into the OpendTect 3d seismic visualization system. Each preliminary fault set includes a continuous trace more than 3000 ft long, and a swarm of short fault strands. The three preliminary normal-fault sets strike northerly with westward dip, northwesterly with northeast dip, and easterly with north dip. An intersection of all three fault systems documented in the seismic sections at the end of Phase I helped to locate the APS-2 and APS-3 slimholes. The seismic sections do not show the faults connected to the Astor Pass tufa spire, suggesting that we have imaged mostly Tertiary-aged faults. We hypothesize that the Recent, active faults that produced the tufa through hotspring

  15. Multi-Pass Quadrupole Mass Analyzer

    Science.gov (United States)

    Prestage, John D.

    2013-01-01

    Analysis of the composition of planetary atmospheres is one of the most important and fundamental measurements in planetary robotic exploration. Quadrupole mass analyzers (QMAs) are the primary tool used to execute these investigations, but reductions in size of these instruments has sacrificed mass resolving power so that the best present-day QMA devices are still large, expensive, and do not deliver performance of laboratory instruments. An ultra-high-resolution QMA was developed to resolve N2 +/CO+ by trapping ions in a linear trap quadrupole filter. Because N2 and CO are resolved, gas chromatography columns used to separate species before analysis are eliminated, greatly simplifying gas analysis instrumentation. For highest performance, the ion trap mode is used. High-resolution (or narrow-band) mass selection is carried out in the central region, but near the DC electrodes at each end, RF/DC field settings are adjusted to allow broadband ion passage. This is to prevent ion loss during ion reflection at each end. Ions are created inside the trap so that low-energy particles are selected by low-voltage settings on the end electrodes. This is beneficial to good mass resolution since low-energy particles traverse many cycles of the RF filtering fields. Through Monte Carlo simulations, it is shown that ions are reflected at each end many tens of times, each time being sent back through the central section of the quadrupole where ultrahigh mass filtering is carried out. An analyzer was produced with electrical length orders of magnitude longer than its physical length. Since the selector fields are sized as in conventional devices, the loss of sensitivity inherent in miniaturizing quadrupole instruments is avoided. The no-loss, multi-pass QMA architecture will improve mass resolution of planetary QMA instruments while reducing demands on the RF electronics for high-voltage/high-frequency production since ion transit time is no longer limited to a single pass. The

  16. Containing epidemic outbreaks by message-passing techniques

    CERN Document Server

    Altarelli, F; Dall'Asta, L; Wakeling, J R; Zecchina, R

    2013-01-01

    The problem of targeted network immunization can be defined as the one of finding a subset of nodes in a network to immunize or vaccinate in order to minimize a tradeoff between the cost of vaccination and the final (stationary) expected infection under a given epidemic model. Although computing the expected infection is a hard computational problem, simple and efficient mean-field approximations have been put forward in the literature in recent years. The optimization problem can be recast into a constrained one in which the constraints enforce local mean-field equations describing the average stationary state of the epidemic process. For a wide class of epidemic models, including the susceptible-infected-removed and the susceptible-infected-susceptible models, we define a message-passing approach to network immunization that allows us to study the statistical properties of epidemic outbreaks in the presence of immunized nodes as well as to find (nearly) optimal immunization sets for a given choice of parame...

  17. Algorithmic Verification of Single-Pass List Processing Programs

    CERN Document Server

    Alur, Rajeev

    2010-01-01

    We identify a class of programs manipulating lists of data items for which checking functional equivalence and pre/post verification conditions is decidable. Lists are modeled as data words, (unbounded) sequences of data values, tagged with symbols from a finite set, over a potentially infinite data domain that supports only the operations of equality and ordering. First, we introduce streaming data-word transducers that map input data words to output data words in a single left-to-right pass in linear time. The transducer uses a finite set of states, a finite set of variables ranging over data domain, and a finite set of variables ranging over data words. At every step, it can make decisions based on the next input symbol, updating its state, remembering the input data value in its data variables, and updating data-word variables by concatenating data-word variables and new symbols formed from data variables, while avoiding duplication. Second, we establish Pspace bounds for the problems of checking function...

  18. Distributed Programming via Safe Closure Passing

    Directory of Open Access Journals (Sweden)

    Philipp Haller

    2016-02-01

    Full Text Available Programming systems incorporating aspects of functional programming, e.g., higher-order functions, are becoming increasingly popular for large-scale distributed programming. New frameworks such as Apache Spark leverage functional techniques to provide high-level, declarative APIs for in-memory data analytics, often outperforming traditional "big data" frameworks like Hadoop MapReduce. However, widely-used programming models remain rather ad-hoc; aspects such as implementation trade-offs, static typing, and semantics are not yet well-understood. We present a new asynchronous programming model that has at its core several principles facilitating functional processing of distributed data. The emphasis of our model is on simplicity, performance, and expressiveness. The primary means of communication is by passing functions (closures to distributed, immutable data. To ensure safe and efficient distribution of closures, our model leverages both syntactic and type-based restrictions. We report on a prototype implementation in Scala. Finally, we present preliminary experimental results evaluating the performance impact of a static, type-based optimization of serialization.

  19. Airborne Radar Interferometric Repeat-Pass Processing

    Science.gov (United States)

    Hensley, Scott; Michel, Thierry R.; Jones, Cathleen E.; Muellerschoen, Ronald J.; Chapman, Bruce D.; Fore, Alexander; Simard, Marc; Zebker, Howard A.

    2011-01-01

    Earth science research often requires crustal deformation measurements at a variety of time scales, from seconds to decades. Although satellites have been used for repeat-track interferometric (RTI) synthetic-aperture-radar (SAR) mapping for close to 20 years, RTI is much more difficult to implement from an airborne platform owing to the irregular trajectory of the aircraft compared with microwave imaging radar wavelengths. Two basic requirements for robust airborne repeat-pass radar interferometry include the ability to fly the platform to a desired trajectory within a narrow tube and the ability to have the radar beam pointed in a desired direction to a fraction of a beam width. Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) is equipped with a precision auto pilot developed by NASA Dryden that allows the platform, a Gulfstream III, to nominally fly within a 5 m diameter tube and with an electronically scanned antenna to position the radar beam to a fraction of a beam width based on INU (inertial navigation unit) attitude angle measurements.

  20. Single Pass Multi-component Harvester

    Energy Technology Data Exchange (ETDEWEB)

    Reed Hoskinson; J. Richard Hess

    2004-08-01

    Abstract. In order to meet the U. S. government’s goal of supplementing the energy available from petroleum by increasing the production of energy from renewable resources, increased production of bioenergy has become one of the new goals of the United States government and our society. U.S. Executive Orders and new Federal Legislation have mandated changes in government procedures and caused reorganizations within the government to support these goals. The Biomass Research and Development Initiative is a multi-agency effort to coordinate and accelerate all U.S. Federal biobased products and bioenergy research and development. The Initiative is managed by the National Biomass Coordination Office, which is staffed by both the DOE and the USDA. One of the most readily available sources of biomass from which to produce bioenergy is an agricultural crop residue, of which straw from small grains is the most feasible residue with which to start. For the straw residue to be used its collection must be energy efficient and its removal must not impact the sustainability of the growing environment. In addition, its collection must be economically advantageous to the producer. To do all that, a single pass multi-component harvester system is most desirable. Results from our first prototype suggest that current combines probably do adequate threshing and that a separate chassis can be developed that does additional separation and that is economically feasible.

  1. How My Program Passed the Turing Test

    Science.gov (United States)

    Humphrys, Mark

    In 1989, the author put an ELIZA-like chatbot on the Internet. The conversations this program had can be seen - depending on how one defines the rules (and how seriously one takes the idea of the test itself) - as a passing of the Turing Test. This is the first time this event has been properly written. This chatbot succeeded due to profanity, relentless aggression, prurient queries about the user, and implying that they were a liar when they responded. The element of surprise was also crucial. Most chatbots exist in an environment where people expectto find some bots among the humans. Not this one. What was also novel was the onlineelement. This was certainly one of the first AI programs online. It seems to have been the first (a) AI real-time chat program, which (b) had the element of surprise, and (c) was on the Internet. We conclude with some speculation that the future of all of AI is on the Internet, and a description of the "World- Wide-Mind" project that aims to bring this about.

  2. Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.

    Science.gov (United States)

    Clayton, Amy C; Bentz, Joel S; Wasserman, Patricia G; Schwartz, Mary R; Souers, Rhona J; Chmara, Beth Anne; Laucirica, Rodolfo; Clary, Karen M; Moriarty, Ann T

    2010-08-01

    Differences in participant responses for ThinPrep (TP) and non-ThinPrep (NTP) preparations for gastrointestinal cytology challenges, which circulated in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology (CAP NGC), may help to identify performance variations between preparation types. To compare the performance of TP-prepared slides of gastrointestinal exfoliative cytology specimens to that of NTP preparations in the CAP NGC program. Participant responses between 2000 and 2007 were evaluated for esophageal wash/brush, gastric wash/brush, and biliary tract brush specimens with a reference diagnosis of adenocarcinoma, squamous cell carcinoma, carcinoid, or spindle cell neoplasm. ThinPrep challenges were compared with NTP preparations (conventional smears, cytospins) for discordant responses. In all, 6023 pathologist responses and 3825 cytotechnologist responses were reviewed. Non-ThinPrep preparations comprised 93% (n = 11 588) of the challenges, while 7% (n = 912) were TP material. A match for a "positive/suspicious" diagnosis was seen in 88.5% of NTP and 95.9% of TP preparations (P cytology specimens circulated in an interlaboratory comparison program. Performance varied by reference interpretation, with the best performance for the interpretation of adenocarcinoma. Cytotechnologists and pathologists performed at the same level overall, but with differences for the diagnosis of spindle cell neoplasm and squamous carcinoma.

  3. Access to Basic HIV-Related Services and PrEP Acceptability among Men Who Have sex with Men Worldwide: Barriers, Facilitators, and Implications for Combination Prevention

    Directory of Open Access Journals (Sweden)

    George Ayala

    2013-01-01

    Full Text Available Introduction. Men who have sex with men (MSM are disproportionately impacted by HIV globally. Easily accessible combination HIV prevention strategies, tailored to the needs of MSM, are needed to effectively address the AIDS pandemic. Methods and Materials. We conducted a cross-sectional study among MSM (n=3748 from 145 countries from April to August 2012. Using multivariable random effects models, we examined factors associated with acceptability of preexposure prophylaxis (PrEP and access to condoms, lubricants, HIV testing, and HIV treatment. Results. Condoms and lubricants were accessible to 35% and 22% of all respondents, respectively. HIV testing was accessible to 35% of HIV-negative respondents. Forty-three percent of all HIV-positive respondents reported that antiretroviral therapy was easily accessible. Homophobia, outness, and service provider stigma were significantly associated with reduced access to services. Conversely, community engagement, connection to gay community, and comfort with service providers were associated with increased access. PrEP acceptability was associated with lower PrEP-related stigma, less knowledge about PrEP, less outness, higher service provider stigma, and having experienced violence for being MSM. Conclusions. Ensuring HIV service access among MSM will be critical in maximizing the potential effectiveness of combination approaches, especially given the interdependence of both basic and newer interventions like PrEP. Barriers and facilitators of HIV service access for MSM should be better understood and addressed.

  4. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  5. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  6. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  7. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

    Science.gov (United States)

    Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein; Kirschner, Benny; Rozemeijer, Kirsten; Bonde, Jesper; Rygaard, Carsten; Lynge, Elsebeth

    2015-01-01

    Background: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories. Methods: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity. Results: At 23–29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30–44 years, the increase with SurePath/FocalPoint was 58% the 16% increase with ThinPrep was not significant. At 45–59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23–29 years, but decreased by two-thirds at 45–59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen. Conclusions: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent. PMID:26448176

  8. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  9. The Effect of Metacognitive Strategy Training on Science Process Skills and Science Self Efficacy among First Year Prep Students with Learning Disabilities

    Science.gov (United States)

    Gomaa, Omema Mostafa Kamel

    2016-01-01

    This study investigated the effect of using metacognitive strategy training on science process skills and science self efficacy in learning disabled first year prep students. A total of 60 students identified with LD were invited to participate. The sample was randomly divided into two groups; experimental (n = 30 boys) and control (n = 30 boys ).…

  10. The Effectiveness of Heat Exchangers with One Shell Pass and Three Tube Passes.

    Science.gov (United States)

    1985-06-01

    Yorf, NY, 1973. 14. Chapra , S. C. and Canale, R. P., Numerical Methods for Engineers with Personal Computer Applications, "Mcraw-Hill Book Company, New...Effectiveness Ntu Method Three Tube Passes 20. ABSTRACT eConrnue an rere aid4eIf nocesey and Identify by block m bi6e r .Heat exchangers with one shell...THE DEVELOPMENT OF THE EFFECTIVENESS METHOD . . .. 20 A. LITERATURE SURVEY . . . . . . .......... 20 B. FISCHER’S WORK . . . . . . . . ......... 23

  11. Nursing students' attendance at learning activities in relation to attainment and passing courses: A prospective quantitative study.

    Science.gov (United States)

    Rejnö, Åsa; Nordin, Per; Forsgren, Susanne; Sundell, Yvonne; Rudolfsson, Gudrun

    2017-03-01

    Students' motivation and ways of engaging in their schoolwork are important for their performance, including passing exams. Attendance at learning activities has also been argued to be of major importance, although no causal relationship with passing exams has been established in nursing education. The aim of this study was to describe the impact of attendance at nonmandatory learning activities on attainment, in terms of passing or failing of exams, in nursing education courses including both mandatory and non-mandatory activities. A prospective quantitative design. The nursing education programme at a Swedish university. Nursing students (n=361) from two courses and four classes within the nursing programme. Attendance was registered at every non-mandatory teaching activity by asking the students to note their attendance on a list. Data such as sex, age, and whether the students had passed the exam were also collected for each course and each semester separately. Increased participation was associated with an increasing proportion of students passing the exam. The chance of passing the exam increased by 13% for every additional learning occasion attended. Logistic regression showed an OR of 5.4 for an attendance of 100%. An increase in attendance gave a higher proportion of exam passes. Encouraging students to attend non-mandatory learning activities could be of value, and potentially contribute to an increased graduation rate for nursing students. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Introduction of the Thin Prep Imaging System™ (TIS: Experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-01-01

    Full Text Available Objective: Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women′s Hospital. We introduced the TIS in December 2004. Methods: The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003-November 2004 are taken as the historic control group for our study. Results :The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022 . The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion :The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  13. Acceptability of an open-label wait-listed trial design: Experiences from the PROUD PrEP study

    Science.gov (United States)

    Brodnicki, Elizabeth; Desai, Monica; McCormack, Sheena; Nutland, Will; Wayal, Sonali; White, Ellen; Wood, Gemma; Barber, Tristan; Bell, Gill; Clarke, Amanda; Dolling, David; Dunn, David; Fox, Julie; Haddow, Lewis; Lacey, Charles; Nardone, Anthony; Quinn, Killian; Rae, Caroline; Reeves, Iain; Rayment, Michael; White, David; Apea, Vanessa; Ayap, Wilbert; Dewsnap, Claire; Collaco-Moraes, Yolanda; Schembri, Gabriel; Sowunmi, Yinka; Horne, Rob

    2017-01-01

    Background PROUD participants were randomly assigned to receive pre-exposure prophylaxis (PrEP) immediately or after a deferred period of one-year. We report on the acceptability of this open-label wait-listed trial design. Methods Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. We also conducted in-depth interviews (IDI) with a purposely selected sub-sample of participants. Results Acceptability questionnaires were completed by 76% (415/544) of participants. After controlling for age, immediate-group participants were almost twice as likely as deferred-group participants to complete the questionnaire (AOR:1.86;95%CI:1.24,2.81). In quantitative data, the majority of participants in both groups found the wait-listed design acceptable when measured by satisfaction of joining the study, intention to remain in the study, and interest in joining a subsequent study. However, three-quarters thought that the chance of being in the deferred-group might put other volunteers off joining the study. In free-text responses, data collection tools were the most frequently reported least liked aspect of the study. A fifth of deferred participants reported ‘being deferred’ as the thing they least liked about the study. However, more deferred participants disliked the data collection tools than the fact that they had to wait a year to access PrEP. Participants in the IDIs had a good understanding of the rationale for the open-label wait-listed study design. Most accepted the design but acknowledged they were, or would have been, disappointed to be randomised to the deferred group. Five of the 25 participants interviewed reported some objection to the wait-listed design. Conclusion The quantitative and qualitative findings suggest that in an environment where PrEP was not available, the rationale for the wait-listed trial design was well understood and

  14. Evaluation of the Illumina(®) Beta Version ForenSeq™ DNA Signature Prep Kit for use in genetic profiling.

    Science.gov (United States)

    Churchill, Jennifer D; Schmedes, Sarah E; King, Jonathan L; Budowle, Bruce

    2016-01-01

    While capillary electrophoresis-based technologies have been the mainstay for human identity typing applications, there are limitations with this methodology's resolution, scalability, and throughput. Massively parallel sequencing (MPS) offers the capability to multiplex multiple types of forensically-relevant markers and multiple samples together in one run all at an overall lower cost per nucleotide than traditional capillary electrophoresis-based methods; thus, addressing some of these limitations. MPS also is poised to expand forensic typing capabilities by providing new strategies for mixture deconvolution with the identification of intra-STR allele sequence variants and the potential to generate new types of investigative leads with an increase in the overall number and types of genetic markers being analyzed. The beta version of the Illumina ForenSeq DNA Signature Prep Kit is a MPS library preparation method with a streamlined workflow that allows for targeted amplification and sequencing of 63 STRs and 95 identity SNPs, with the option to include an additional 56 ancestry SNPs and 22 phenotypic SNPs depending on the primer mix chosen for amplification, on the MiSeq desktop sequencer (Illumina). This study was divided into a series of experiments that evaluated reliability, sensitivity of detection, mixture analysis, concordance, and the ability to analyze challenged samples. Genotype accuracy, depth of coverage, and allele balance were used as informative metrics for the quality of the data produced. The ForenSeq DNA Signature Prep Kit produced reliable, reproducible results and obtained full profiles with DNA input amounts of 1ng. Data were found to be concordant with current capillary electrophoresis methods, and mixtures at a 1:19 ratio were resolved accurately. Data from the challenged samples showed concordant results with current DNA typing methods with markers in common and minimal allele drop out from the large number of markers typed on these

  15. Single pass kernel -means clustering method

    Indian Academy of Sciences (India)

    T Hitendra Sarma; P Viswanath; B Eswara Reddy

    2013-06-01

    In unsupervised classification, kernel -means clustering method has been shown to perform better than conventional -means clustering method in identifying non-isotropic clusters in a data set. The space and time requirements of this method are $O(n^2)$, where is the data set size. Because of this quadratic time complexity, the kernel -means method is not applicable to work with large data sets. The paper proposes a simple and faster version of the kernel -means clustering method, called single pass kernel k-means clustering method. The proposed method works as follows. First, a random sample $\\mathcal{S}$ is selected from the data set $\\mathcal{D}$. A partition $\\Pi_{\\mathcal{S}}$ is obtained by applying the conventional kernel -means method on the random sample $\\mathcal{S}$. The novelty of the paper is, for each cluster in $\\Pi_{\\mathcal{S}}$, the exact cluster center in the input space is obtained using the gradient descent approach. Finally, each unsampled pattern is assigned to its closest exact cluster center to get a partition of the entire data set. The proposed method needs to scan the data set only once and it is much faster than the conventional kernel -means method. The time complexity of this method is $O(s^2+t+nk)$ where is the size of the random sample $\\mathcal{S}$, is the number of clusters required, and is the time taken by the gradient descent method (to find exact cluster centers). The space complexity of the method is $O(s^2)$. The proposed method can be easily implemented and is suitable for large data sets, like those in data mining applications. Experimental results show that, with a small loss of quality, the proposed method can significantly reduce the time taken than the conventional kernel -means clustering method. The proposed method is also compared with other recent similar methods.

  16. Self-Esteem and Hopelessness Levels of Grade-Passing and Class-Repeating Students

    Science.gov (United States)

    Sezer, Ozcan

    2007-01-01

    An analysis of the relevant literature reveals that most studies on self-esteem and hopelessness levels of repeating students examine levels of success and failure among students from various educational stages, with demographic variables such as socioeconomic characteristics, race, sex, and self-concept. There are few previous studies about the…

  17. Class distinction

    Science.gov (United States)

    White, M. Catherine

    Typical 101 courses discourage many students from pursuing higher level science and math courses. Introductory classes in science and math serve largely as a filter, screening out all but the most promising students, and leaving the majority of college graduates—including most prospective teachers—with little understanding of how science works, according to a study conducted for the National Science Foundation. Because few teachers, particularly at the elementary level, experience any collegiate science teaching that stresses skills of inquiry and investigation, they simply never learn to use those methods in their teaching, the report states.

  18. Class Dismissed? Historical Materialism and the Politics of "Difference"

    Science.gov (United States)

    Scatamburlo-D'Annibale, Valerie; McLaren, Peter

    2004-01-01

    Perhaps one of the most taken-for-granted features of contemporary social theory is the ritual and increasingly generic critique of Marxism in terms of its alleged failure to address forms of oppression other than that of "class." Marxism is considered to be theoretically bankrupt and intellectually passe, and class analysis is often savagely…

  19. A semantic theory for value-passing processes based on the late approach

    DEFF Research Database (Denmark)

    Ingolfsdottir, Anna

    2003-01-01

    class of denotational models for the late semantics is defined. A denotational model for the concrete language is given as an instantiation of the general class. Two equationally based proof systems are defined. The first one, which is value-finitary, i. e. only reasons about a finite number of values...... at each time, is shown to be sound and complete with respect to this model. The second proof system, a value-infinitary one, is shown to be sound with respect to the model, whereas the completeness is proven later. The operational and the denotational semantics are compared and it is shown......A general class of languages for value-passing calculi based on the late semantic approach is defined and a concrete instantiation of the general syntax is given. This is a modification of the standard CCS according to the late approach. Three kinds of semantics are given for this language. First...

  20. Fine-needle aspiration cytology of mammary fibroadenoma: a comparison of ThinPrep® and cytospin preparations.

    Science.gov (United States)

    Ly, Thai Yen; Barnes, Penny J; Macintosh, Rebecca F

    2011-03-01

    Mammary fibroadenoma (FA) is a lesion frequently sampled and diagnosed by fine-needle aspiration (FNA). Accurate cytologic diagnosis of this common benign lesion is important as this can lead to non-surgical, conservative management when breast imaging and clinical examination are concordant. In most instances, a confident diagnosis of FA is possible because of a characteristic cytologic appearance that includes hypercellularity, large epithelial cell groups, staghorn epithelial configurations, stromal fragments, and numerous background stripped nuclei. Nevertheless, FAs can be diagnostically challenging because of shared cytomorphologic features with other benign lesions and low-grade carcinoma. As such, FA is a well-recognized source of false results on FNA cytology. Furthermore, there are reports that newer thin layer cytopreparatory techniques, including the ThinPrep® (TP) system (Hologic Corp., Bedford, MA), alter the appearance of FA on FNA compared to conventional preparations and may compromise accurate cytologic diagnosis. Copyright © 2010 Wiley-Liss, Inc.

  1. Guide for the preparation of proposals for the Pre-Freshman Engineering Program: PREP - 1984 (for minorities and women)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1983-08-01

    The Pre-Freshman Engineering Program (PREP) for minorities and women (formerly PREFACE) will provide funds to colleges and universities for projects aimed at seeking out minority group individuals and women during junior high school and high school years (7th grade through 12th grade) and providing them with enrichment experiences. These experiences shall consist of activities to identify, motivate and prepare students for engineering studies. Emphasis is on the individuals identified, regardless of where they may decide to matriculate for undergraduate studies. Work experience is believed to contribute to the success of these projects because it exposes students to the real world of work of the professional engineer. However, no DOE funds may be used directly to support such work experiences. Eligible organizations, limitations of funding, preparation and submission of proposals, evaluation and selection of proposals, and the final report are discussed.

  2. Distribution of Longitudinal Inherent Strains in Multiple-passes Welding

    Institute of Scientific and Technical Information of China (English)

    Peng HE; Jiuhai ZHANG; Toshio Terasaki; Testuya Akiyama

    2001-01-01

    A fundamental theory for the analysis of residual welding stresses and deformation based on the inherent strain distribution along the welded joint is introduced. The computing method of distribution of longitudinal inherent strains in multiple-passes welding in heavy plate weldment is proposed. Distribution of longitudinal inherent strains in one-pass welding and two-passes welding are compared and analyzed. The effect of cutting on inherent strain is discussed.

  3. Calculation of trajectory parameters of long pass in basketball.

    Directory of Open Access Journals (Sweden)

    Charikova K.M.

    2011-08-01

    Full Text Available Values of a ball's flight trajectory parameters depending on a distance of long pass, a corner of a ball's start and height of a throwing point are submitted in article. Coordinates of reference points installation for training to long pass with an optimum trajectory of a ball's flight are designed. Requirements to simulators design are determined. Corners of ball's long pass performance in various game situations are recommended.

  4. The Single Pass Multi-component Harvester

    Energy Technology Data Exchange (ETDEWEB)

    Reed Hoskinson; John R. Hess

    2004-08-01

    collection must be economically advantageous to the producer. To do all that, a single pass multi-component harvester system is most desirable. Results from our first prototype suggest that current combines probably do adequate threshing and that a separate chassis can be developed that does additional separation and that is economically feasible.

  5. Chelyabinsk fireball and Dyatlov pass tragedy

    Science.gov (United States)

    Kochemasov, G. G.

    2013-09-01

    The Chelyabinsk bolide as well as the Kunashak meteorite in 1949 (Fig. 3, black square) hit ground in ectonically peculiar place in the Ural Mountains. The main explosion was followed by a series of weaker bangs. The long Uralian fold belt (Pz) separates two subsectors (1 & 2, Fig. 1) of the Eurasian sector (1+2) of the Eastern hemisphere sectoral structure (Fig. 1). At the Pamirs-Hindukush massif (the "Pamirs' cross") meet four tectonic sectors of this structure: two opposite differently uplifted (Africa-Mediterranean ++ and Asian +) and separating them two opposite differently subsided (Eurasian - and Indooceanic - -). Tectonic bisectors divide the sectors into two differently tectonically elevated subsectors. The Ural Mountains is one of these bisectors dividing the somewhat risen East-European subsector and the relatively fallen West-Siberian one. Even more important is the sharp tectonic boundary between subsided Eurasian sector and uplifted Asian one (between 2 and 3, Fig. 1). Fig. 3 shows distribution of electrophonic bolides over USSR [1]. Observations numbers are in circles. The total of 343 observations is distributed at relevant districts; accompanied meteorites were found only in 23-24 cases; in the chart are excluded background values of 1-2 observations per district. Two areas are obviously anomalous. These of the Urals, and the Eurasia-Asia sectoral contact (Novosibirsk - Yenisei R. - Tunguska). A location in the long Uralian belt is determined by its intersection with the Timan fold belt coming from the northwest (Fig. 3). The catastrophic Dyatlov pass where nine people mysteriously died at once occurs there (triangle in Fig. 3). Mancy aborigines know this place as deadly where killing white shining spheres appear. Moreover this belt intersection is well known among hunters for UFO as the Permian triangle (Fig. 2). They meet there to observe unusual atmospheric shining and other anomalous phenomena. In the Yenisei-Tunguska-Baikal region lightning

  6. Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.

    Directory of Open Access Journals (Sweden)

    Sebastiaan M Bol

    Full Text Available BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD. While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocognitive disorders persist with a high prevalence. To identify additional therapeutic targets for treating HIV-associated neurocognitive disorders, several candidate gene polymorphisms have been evaluated, but few have been replicated across multiple studies. METHODS: We here tested 7 candidate gene polymorphisms for association with HAD in a case-control study consisting of 86 HAD cases and 246 non-HAD AIDS patients as controls. Since infected monocytes and macrophages are thought to play an important role in the infection of the brain, 5 recently identified single nucleotide polymorphisms (SNPs affecting HIV-1 replication in macrophages in vitro were also tested. RESULTS: The CCR5 wt/Δ32 genotype was only associated with HAD in individuals who developed AIDS prior to 1991, in agreement with the observed fading effect of this genotype on viral load set point. A significant difference in genotype distribution among all cases and controls irrespective of year of AIDS diagnosis was found only for a SNP in candidate gene PREP1 (p = 1.2 × 10(-5. Prep1 has recently been identified as a transcription factor preferentially binding the -2,518 G allele in the promoter of the gene encoding MCP-1, a protein with a well established role in the etiology of HAD. CONCLUSION: These results support previous findings suggesting an important role for MCP-1 in the onset of HIV-1-associated neurocognitive disorders.

  7. Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study

    Science.gov (United States)

    d'Assuncao, Jefferson; Irwig, Les; Macaskill, Petra; Chan, Siew F; Richards, Adele; Farnsworth, Annabelle

    2007-01-01

    Objective To compare the accuracy of liquid based cytology using the computerised ThinPrep Imager with that of manually read conventional cytology. Design Prospective study. Setting Pathology laboratory in Sydney, Australia. Participants 55 164 split sample pairs (liquid based sample collected after conventional sample from one collection) from consecutive samples of women choosing both types of cytology and whose specimens were examined between August 2004 and June 2005. Main outcome measures Primary outcome was accuracy of slides for detecting squamous lesions. Secondary outcomes were rate of unsatisfactory slides, distribution of squamous cytological classifications, and accuracy of detecting glandular lesions. Results Fewer unsatisfactory slides were found for imager read cytology than for conventional cytology (1.8% v 3.1%; Pcytology (7.4% v 6.0% overall and 2.8% v 2.2% for cervical intraepithelial neoplasia of grade 1 or higher). Among 550 patients in whom imager read cytology was cervical intraepithelial neoplasia grade 1 or higher and conventional cytology was less severe than grade 1, 133 of 380 biopsy samples taken were high grade histology. Among 294 patients in whom imager read cytology was less severe than cervical intraepithelial neoplasia grade 1 and conventional cytology was grade 1 or higher, 62 of 210 biopsy samples taken were high grade histology. Imager read cytology therefore detected 71 more cases of high grade histology than did conventional cytology, resulting from 170 more biopsies. Similar results were found when one pathologist reread the slides, masked to cytology results. Conclusion The ThinPrep Imager detects 1.29 more cases of histological high grade squamous disease per 1000 women screened than conventional cytology, with cervical intraepithelial neoplasia grade 1 as the threshold for referral to colposcopy. More imager read slides than conventional slides were satisfactory for examination and more contained low grade cytological

  8. The design of thin disk laser multi-pass amplifier

    Science.gov (United States)

    Song, Enmao; Zhu, Guangzhi; Zhu, Xiao; Yu, Jinbo; Zhao, Wenguang

    2016-11-01

    In this paper, a thin disk multi-pass amplification system is designed based on the conjugated double parabolic mirror pumping thin disk laser module, which realizes 20 passes transmitting through the thin disk crystal. The light transmission matrix is used to optimize optical mode matching of seed laser spot size and pumping spot size during the multi-pass transmission. At the same time, anti-misalignment stability of the thin disk multi-pass amplification system and the aberration of output laser beam are analyzed in deeply.

  9. Railroad Pass Evaluation Nevada-Utah Siting Area.

    Science.gov (United States)

    1979-11-16

    Pass, Snake & Spring. NV. Curves Mining Claims Moderate Numero GOLDFIELD HILLS Gradual Mines Low to 3 (b) 8 5600 N-S Curves at Moderate Numeroo Big... Numero Milford & Wah Wah. UT. Curves HALFWAY SUMMIT One or Two 8 (a) 2 6250 NE-SW Sharp At Pass, Roae Moderate Severs Pine & Snake. UT. Curves HANCOCK...At Pass, Road Moderate Numero Stone Cabin & Ralston. NV. Curves MELOY SUMMIT One or Lak & M IT 4 (a) 6 6800 E-W Two Sharp At Pass Moderate Numeroe

  10. An area efficient low noise 100 Hz low-pass filter

    DEFF Research Database (Denmark)

    Ølgaard, Christian; Sassene, Haoues; Perch-Nielsen, Ivan R.

    1996-01-01

    scaling technique. The two filters utilize approximately the same silicon area. The scaled filter implements the scaling by use of a MOS based current conveyor type CCII. Measurements indicate that the current scaled filter results in a noise improvement of approximately 5.5 dB over the reference filter......A technique based on scaling a filter's capacitor currents to improve the noise performance of low frequency continuous-time filters is presented. Two 100 Hz low-pass filters have been implemented: a traditional low pass filter (as reference), and a filter utilizing the above mentioned current...... when a class A/B biasing scheme is used in the current divider. Obtaining identical noise performance from the reference filter would require a 3.6 times larger filter capacitor. This would increase the reference filter's die area by 100%. Therefore, the current scaling technique allows filters...

  11. Second Order Low-Pass and High-Pass Filter Designs Using Method of Synthetic Immitance Elements

    Directory of Open Access Journals (Sweden)

    Pavel Brandstetter

    2013-01-01

    Full Text Available The paper briefly describes the basics of frequency filter design method using synthetic immittance elements with current conveyors. An introduction of the paper explains the advantages and also disadvantages of using this method. Other chapters briefly introduce a design process of simple second order low-pass and high-pass filter. A theory of current conveyors is discussed too, because they are the basic building blocs of proposed synthetic element and also active frequency filters. Finally, the particular solutions of low-pass and high-pass filters are given and verified by OrCAD PSpice simulations.

  12. Class size reduction in the second language classroom

    OpenAIRE

    García Bayonas, Mariche; Gottschall, Holli

    2008-01-01

    In this study, class size reduction (CSR) was implemented in six sections of second semester, university level Spanish classes in which the enrollment cap was lowered from 27 to 20 students. The methodology for the study included a student opinion questionnaire, classroom observations, and student course grades. The study aimed at finding the effect of CSR on student participation, motivation, passing rates and dropout rates. Results showed that students in smaller classes have a higher numbe...

  13. Safety analysis of passing maneuvers using extreme value theory

    Directory of Open Access Journals (Sweden)

    Haneen Farah

    2017-04-01

    The results indicate that this is a promising approach for safety evaluation. On-going work of the authors will attempt to generalize this method to other safety measures related to passing maneuvers, test it for the detailed analysis of the effect of demographic factors on passing maneuvers' crash probability and for its usefulness in a traffic simulation environment.

  14. 33 CFR 117.436 - Chef Menteur Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Chef Menteur Pass. 117.436 Section 117.436 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.436 Chef Menteur Pass. The draw of...

  15. 20 CFR 631.38 - State by-pass authority.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State by-pass authority. 631.38 Section 631.38 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE III OF THE JOB TRAINING PARTNERSHIP ACT State Administration § 631.38 State by-pass authority....

  16. 33 CFR 117.267 - Big Carlos Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Big Carlos Pass. 117.267 Section 117.267 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.267 Big Carlos Pass. The draw of...

  17. 24 CFR 3286.509 - Reinspection upon failure to pass.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Reinspection upon failure to pass. 3286.509 Section 3286.509 Housing and Urban Development Regulations Relating to Housing and Urban...-Administered States § 3286.509 Reinspection upon failure to pass. (a) Procedures for failed inspection. If...

  18. 33 CFR 117.499 - Tante Phine Pass.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Tante Phine Pass. 117.499 Section 117.499 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.499 Tante Phine Pass. The draw of...

  19. Variation of rolling noise during train pass-bys

    NARCIS (Netherlands)

    Dittrich, M.G.

    2013-01-01

    Railway pass-by noise measurements on different types of tracks sometimes display a significant difference between the rise and decrease in rolling noise at the front and the back of the train. This can potentially have different causes. Whilst this may not necessarily be relevant for the total pass

  20. Teaching Strategies for the Forearm Pass in Volleyball

    Science.gov (United States)

    Casebolt, Kevin; Zhang, Peng; Brett, Christine

    2014-01-01

    This article shares teaching strategies for the forearm pass in the game of volleyball and identifies how they will help students improve their performance and development of forearm passing skills. The article also provides an assessment rubric to facilitate student understanding of the skill.

  1. Teaching Strategies for the Forearm Pass in Volleyball

    Science.gov (United States)

    Casebolt, Kevin; Zhang, Peng; Brett, Christine

    2014-01-01

    This article shares teaching strategies for the forearm pass in the game of volleyball and identifies how they will help students improve their performance and development of forearm passing skills. The article also provides an assessment rubric to facilitate student understanding of the skill.

  2. Effect of Thin Prep® imaging system on laboratory rate and relative sensitivity of atypical squamous cells, high-grade squamous intraepithelial lesion not excluded and high-grade squamous intraepithelial lesion interpretations

    OpenAIRE

    Brooke R Koltz; Russell, Donna K; Naiji Lu; Bonfiglio, Thomas A.; Sharlin Varghese

    2013-01-01

    Introduction: Automated screening of Thin Prep ® Papanicolaou Tests has become increasingly common in clinical practice. Increased productivity has initiated laboratory use of the Thin Prep ® Imaging System (TIS). Increased sensitivity is a potential additional benefit of TIS. Published studies have shown an increase in discovery of dysplastic cells. This study evaluates the effect of TIS on the incidence of atypical squamous cells high-grade squamous intraepithelial lesion not excluded (ASC-...

  3. Performance evaluation of the new Roche cobas AmpliPrep/cobas TaqMan HCV test, version 2.0, for detection and quantification of hepatitis C virus RNA

    NARCIS (Netherlands)

    S.D. Pas (Suzan); R. Molenkamp (Richard); J. Schinkel (Janke); S. Rebers; C. Copra (Cederick); S. Seven-Deniz; D. Thamke (Diana); R.J. de Knegt (Robert); B.L. Haagmans (Bart); M. Schutten (Martin)

    2013-01-01

    textabstractTo evaluate the analytical performance and explore the clinical applicability of the new Roche cobas AmpliPrep/cobas TaqMan HCV test, v2.0 (CAP/CTM v2.0), a platform comparison was performed on panels and diagnostic samples with the Roche cobas AmpliPrep/cobas TaqMan HCV test (CAP/CTM v1

  4. Correlates of Awareness of and Willingness to Use Pre-exposure Prophylaxis (PrEP) in Gay, Bisexual, and Other Men Who Have Sex with Men Who Use Geosocial-Networking Smartphone Applications in New York City.

    Science.gov (United States)

    Goedel, William C; Halkitis, Perry N; Greene, Richard E; Duncan, Dustin T

    2016-07-01

    Geosocial-networking smartphone applications are commonly used by gay, bisexual, and other men who have sex with men (MSM) to meet sexual partners. The purpose of the current study was to evaluate awareness of and willingness to use pre-exposure prophylaxis (PrEP) among MSM who use geosocial-networking smartphone applications residing in New York City. Recruitment utilizing broadcast advertisements on a popular smartphone application for MSM yielded a sample of 152 HIV-uninfected MSM. Multivariable models were used to assess demographic and behavioral correlates of awareness of and willingness to use PrEP. Most participants (85.5 %) had heard about PrEP but few (9.2 %) reported current use. Unwillingness to use PrEP was associated with concerns about side effects (PR = 0.303; 95 % CI 0.130, 0.708; p = 0.006). Given that more than half (57.6 %) of participants were willing to use PrEP, future research is needed to elucidate both individual and structural barriers to PrEP use among MSM.

  5. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein;

    2015-01-01

    BACKGROUND: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories. METHODS: Using data from five...... nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests...... an indicator of relative specificity. RESULTS: At 23-29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30-44 years, the increase with Sure...

  6. Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study.

    Science.gov (United States)

    Schledermann, Doris; Hyldebrandt, Tina; Ejersbo, Dorthe; Hoelund, Berit

    2007-06-01

    The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening procedure was timed for each of the 11,354 slides included. In every slide 22 fields of view were reviewed, and the samples that contained potentially abnormal cells were fully screened. The screening time was reduced by 42% (mean) (p < 0.001). By manual rescreening of the negative TIS samples, abnormal cells were found in 10 samples (false negative rate 0.14%). In every case the abnormal cells had been identified by the scanner, but misinterpreted by the cytotechnologist. These findings stressed the importance of carefulness in the interpretation of the marked fields and beyond that helped the cytotechnologists and pathologists to have more confidence in the automated system.

  7. A case study of chewed Truvada(®) for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

    Science.gov (United States)

    Lalley-Chareczko, Linden; Clark, Devon; Zuppa, Athena F; Moorthy, Ganesh; Conyngham, Caitlin; Mounzer, Karam; Koenig, Helen

    2017-03-06

    FTC/TDF (Truvada®) given as pre-exposure prophylaxis (PrEP) successfully blocks HIV when taken once daily prior to potential HIV exposure. A 22 year old male reported difficulty swallowing FTC/TDF for PrEP and subsequently began chewing the FTC/TDF tablets. Monthly urine samples assessed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) indicated tenofovir levels >1000 ng/mL, indicative of protection from HIV acquisition, over a 48 week period. Data from observational studies of HIV positive patients details the successful treatment of HIV using crushed FTC/TDF delivered via feeding and gastronomy tubes while small, randomized trials of healthy volunteers demonstrate bioequivalence between whole and crushed FTC/TDF.

  8. The Use of REACT Strategy for the Incorporation of the Context of Physics into the Teaching English to the Physics English Prep Students

    Directory of Open Access Journals (Sweden)

    ALİ SÜKRÜ ÖZBAY

    2015-12-01

    Full Text Available The Use of REACT Strategy for the Incorporation of the Context of Physics into the Teaching English to the Physics English Prep Students Abstract  The present study explores department of Physics prep students’ (department of Physics students attending English preparatory program relative performance in English grammar by the use of contextual learning materials in the actual classroom instruction based on the contextual learning theory. Thus, the purpose of this study is to investigate the effect of teaching grammar in physics context for the physics prep students to increase their interests in learning English. Another primary goal of the study is to evaluate the teaching activities which are developed in accordance with the REACT (relating, experiencing, applying, cooperating and transferring strategy in context based approach. The study was with 25 students of Physics at an English prep-school in Turkey. With the aim of determining the effect of contextual teaching materials, sample lessons based on the contextual knowledge and the target grammar points were made. Following the lessons, a structured interview was delivered to the five of the participants. One result is that the incorporation of REACT strategy into the teaching of English to the Physics students proved to be useful for the learners who took part in the study, adding that relating, experiencing, applying, cooperating and transferring the knowledge respectively helped them use and retain the knowledge far more than the traditional classroom teaching methods in grammar teaching. Another specific outcome of the overall findings is that students were able to establish connections between what they learn and how that knowledge can be utilized in physics, which, in turn, has increased their motivation to a higher level.

  9. The Safety of Tenofovir-Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B.

    Science.gov (United States)

    Solomon, Marc M; Schechter, Mauro; Liu, Albert Y; McManhan, Vanessa M; Guanira, Juan V; Hance, Robert J; Chariyalertsak, Suwat; Mayer, Kenneth H; Grant, Robert M

    2016-03-01

    Pre-exposure prophylaxis (PrEP) with daily oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) prevents HIV infection. The safety and feasibility of HIV PrEP in the setting of hepatitis B virus (HBV) infection were evaluated. The Iniciativa Profilaxis Pre-Exposición study randomized 2499 HIV-negative men and transgender women who have sex with men to once-daily oral FTC/TDF versus placebo. Hepatitis serologies and transaminases were obtained at screening and at the time PrEP was discontinued. HBV DNA was assessed by polymerase chain reaction, and drug resistance was assessed by population sequencing. Vaccination was offered to individuals susceptible to HBV infection. Of the 2499 participants, 12 (0.5%; including 6 randomized to FTC/TDF) had chronic HBV infection. After stopping FTC/TDF, 5 of the 6 participants in the active arm had liver function tests performed at follow-up. Liver function tests remained within normal limits at post-stop visits except for a grade 1 elevation in 1 participant at post-stop week 12 (alanine aminotransferase = 90, aspartate aminotransferase = 61). There was no evidence of hepatic flares. Polymerase chain reaction of stored samples showed that 2 participants in the active arm had evidence of acute HBV infection at enrollment. Both had evidence of grade 4 transaminase elevations with subsequent resolution. Overall, there was no evidence of TDF or FTC resistance among tested genotypes. Of 1633 eligible for vaccination, 1587 (97.2%) received at least 1 vaccine; 1383 (84.7%) completed the series. PrEP can be safely provided to individuals with HBV infection if there is no evidence of cirrhosis or substantial transaminase elevation. HBV vaccination rates at screening were low globally, despite recommendations for its use, yet uptake and efficacy were high when offered.

  10. The Safety of Tenofovir–Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B

    Science.gov (United States)

    Schechter, Mauro; Liu, Albert Y.; McManhan, Vanessa M.; Guanira, Juan V.; Hance, Robert J.; Chariyalertsak, Suwat; Mayer, Kenneth H.; Grant, Robert M.

    2016-01-01

    Background: Pre-exposure prophylaxis (PrEP) with daily oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) prevents HIV infection. The safety and feasibility of HIV PrEP in the setting of hepatitis B virus (HBV) infection were evaluated. Methods: The Iniciativa Profilaxis Pre-Exposición study randomized 2499 HIV-negative men and transgender women who have sex with men to once-daily oral FTC/TDF versus placebo. Hepatitis serologies and transaminases were obtained at screening and at the time PrEP was discontinued. HBV DNA was assessed by polymerase chain reaction, and drug resistance was assessed by population sequencing. Vaccination was offered to individuals susceptible to HBV infection. Results: Of the 2499 participants, 12 (0.5%; including 6 randomized to FTC/TDF) had chronic HBV infection. After stopping FTC/TDF, 5 of the 6 participants in the active arm had liver function tests performed at follow-up. Liver function tests remained within normal limits at post-stop visits except for a grade 1 elevation in 1 participant at post-stop week 12 (alanine aminotransferase = 90, aspartate aminotransferase = 61). There was no evidence of hepatic flares. Polymerase chain reaction of stored samples showed that 2 participants in the active arm had evidence of acute HBV infection at enrollment. Both had evidence of grade 4 transaminase elevations with subsequent resolution. Overall, there was no evidence of TDF or FTC resistance among tested genotypes. Of 1633 eligible for vaccination, 1587 (97.2%) received at least 1 vaccine; 1383 (84.7%) completed the series. Conclusions: PrEP can be safely provided to individuals with HBV infection if there is no evidence of cirrhosis or substantial transaminase elevation. HBV vaccination rates at screening were low globally, despite recommendations for its use, yet uptake and efficacy were high when offered. PMID:26413853

  11. Evaluation of a new preparative supercritical fluid chromatography system for compound library purification: the TharSFC SFC-MS Prep-100 system.

    Science.gov (United States)

    Ebinger, Katalin; Weller, Harold N; Kiplinger, Jeffrey; Lefebvre, Paul

    2011-06-01

    Preparative HPLC-MS is often the method of choice for purification of small amounts (<100mg) of diverse new molecules, such as compound libraries for drug discovery. The method is robust, well proven, and widely applicable. In contrast, preparative supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) has seen only slow acceptance for the same application--despite some potential scientific and economic advantages. One of the reasons for slow adoption of SFC-MS is the lack of well-proven, robust, and commercially available instrumentation. In early 2009, TharSFC (a Waters Company, Pittsburgh, PA) introduced a new fully integrated system for preparative SFC-MS: The SFC-MS Prep-100. We report herein an objective evaluation of the SFC-MS Prep-100, including tests for pump and autosampler performance, sample recovery, sample carryover, fraction triggering, detector/fraction collector synchronization, and overall robustness. Our results suggest that the SFC-MS Prep-100 represents a significant advance over previous generation instrumentation.

  12. Clinton and the Process to Pass NAFTA: Making Sausage

    Science.gov (United States)

    2002-01-01

    NATIONAL DEFENSE UNIVERSITY NATIONAL WAR COLLEGE CLINTON AND THE PROCESS TO PASS NAFTA : MAKING SAUSAGE LtCol CHRIS D. McMENOMY, USMC...00-00-2002 to 00-00-2002 4. TITLE AND SUBTITLE Clinton and the Process to Pass NAFTA : Making Sausage 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 CLINTON AND THE PROCESS TO PASS NAFTA : MAKING SAUSAGE President

  13. An Electrostatically Actuated MEMS Arch Band-Pass Filter

    Directory of Open Access Journals (Sweden)

    Hassen M. Ouakad

    2013-01-01

    Full Text Available This work presents an investigation of the dynamics of micromachined arches resonators and their potential to be utilized as band-pass filters. The arches are actuated by a DC electrostatic load superimposed to an AC harmonic load. The dynamic response of the arch is studied analytically using a Galerkin-based reduced-order model when excited near its fundamental and third natural frequencies. Several simulation results are presented demonstrating interesting jumps and snap-through behavior of the arches and their attractive features for uses as band-pass filters, such as their sharp roll-off from pass bands to stop bands and their flat response.

  14. Colour atlas of first pass functional imaging of the heart

    Energy Technology Data Exchange (ETDEWEB)

    Schad, N.; Andrews, E.J.; Fleming, J.W.

    1985-01-01

    This book contains 21 chapters. Some of the titles are: Functional imaging; Fist pass radionuclide studies in evaluation of mitral valve replacement in chronic insufficiency using Bjork-Shiley tilting disc valves; First pass radionuclide studies in evaluation of left and right ventricular function in patients with bioprosthetic mitral valve replacement after 9-11 years; and First pass radionuclide studies in the evaluation of long term (up to about 15 years) follow up of aortic valve replacement using Starr-Edwards ball prosthesis.

  15. On the expressiveness of single-pass instruction sequences

    CERN Document Server

    Bergstra, J A

    2008-01-01

    We perceive programs as single-pass instruction sequences. A single-pass instruction sequence under execution is considered to produce a behaviour to be controlled by some execution environment. Threads as considered in basic thread algebra model such behaviours. We show that all regular threads, i.e. threads that can only be in a finite number of states, can be produced by single-pass instruction sequences without jump instructions if use can be made of Boolean registers. We also show that, in the case where goto instructions are used instead of jump instructions, a bound to the number of labels restricts the expressiveness.

  16. Does the endolymph pass through the base of the cupula?

    Science.gov (United States)

    Jijiwa, H.; Watanabe, N.; Hattori, T.; Matuda, F.; Hashiba, M.; Mizuno, Y.; Shindo, M.; Watanabe, S.

    2001-08-01

    Whether the endolymph of the semicircular canal passes the cupular partition or not was examined using the lateral semicircular canal system of adult pigeons (Columba livia). By applying various pressures by means of injection of a dye solution through the membranous canal, it was found that the dye solution was seen to pass the cupula even under very low pressures when the pressure was increased gradually. When pulled by a magnet, the ultrafine particles of the dextran magnetite contained in the injected fluid were found to pass through the subcupular space without evident increase of the ampullary pressure.

  17. Does the endolymph pass through the base of the cupula?

    Science.gov (United States)

    Jijiwa, H; Watanabe, N; Hattori, T; Matuda, F; Hashiba, M; Mizuno, Y; Shindo, M; Watanabe, S

    2001-01-01

    Whether the endolymph of the semicircular canal passes the cupular partition or not was examined using the lateral semicircular canal system of adult pigeons (Columba livia). By applying various pressures by means of injection of a dye solution through the membranous canal, it was found that the dye solution, was seen to pass the cupula even under very low pressures when the pressure was increased gradually. When pulled by a magnet, the ultrafine particles of the dextran magnetite contained in the injected fluid were found to pass through the subcupular space without evident increase of the ampullary pressure.

  18. Validation of Cobas AmpliPrep/Cobas TaqMan HIV-1 Test on dried blood spots

    Directory of Open Access Journals (Sweden)

    N Ruiz

    2012-11-01

    Full Text Available The plasma specimen is the gold standard for viral load monitoring, the key method to assess the effect of antiviral chemotherapy and to monitor progression of the disease toward AIDS. Nevertheless, several works endorse the use of dried blood spots (DBS on filter paper for the reliable quantification of the levels needed to take therapeutic decisions, detect of treatment failure and monitor the occurrence of drug resistance. The purpose of this study was to validate the use of Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0, with DBS. To evaluate the performance of the above mentioned kit, three stages were involved: 1- Standardization of DBS working conditions, 2- Stability studies at three temperature conditions and 3- Performance evaluation of the kit using this alternative specimen. Additionally, the viral load was quantified in parallel (plasma and DBS to 43 genetically characterized samples, with different levels of viral load. The Pearson correlation coefficient was calculated and the prediction of the value of RNA in plasma starting from the obtained value in DBS was made. Linear regression analysis was performed and coefficients of variation in precision assays were calculated. The best conditions pickups to the work with DBS were: 100 µL of blood (2 spots/50 µl, dried time between 16 and 18 hours at room temperature and, elution of the blood, 2 hours, between 2 and 8°C; in TRIS-EDTA buffer. The samples on DBS proved to be stable during the study periods. A strong correlation was attained between the measurements of viral load in plasma and DBS samples (r=0.96. The detection rate was 90.7 and the coefficient of variation between the values obtained in plasma-DBS sample pairs averaged 3.42%. The CAP/CTM HIV-1 test provided a linear response in DBS, from 330 copies/mL to 420 000 copies/mL. Overall, coefficients of variation in precision tests were below 10%. Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0 had a good

  19. High pre-exposure prophylaxis uptake and early adherence among men who have sex with men and transgender women at risk for HIV Infection: the PrEP Brasil demonstration project.

    Science.gov (United States)

    Hoagland, Brenda; Moreira, Ronaldo I; De Boni, Raquel B; Kallas, Esper G; Madruga, José Valdez; Vasconcelos, Ricardo; Goulart, Silvia; Torres, Thiago S; Marins, Luana M S; Anderson, Peter L; Luz, Paula M; Costa Leite, Iuri da; Liu, Albert Y; Veloso, Valdilea G; Grinsztejn, Beatriz

    2017-04-06

    The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System. HIV-uninfected MSM and TGW in 3 referral centres in Rio de Janeiro and São Paulo were evaluated for eligibility and offered 48 weeks of daily emtricitabine/tenofovir for PrEP. Concentrations of tenofovir diphosphate in dried blood spot samples (DBS) at week 4 after enrolment (early adherence) were measured. Predictors of drug levels were assessed using ordinal logistic regression models considering the DBS drug level as a 3 level variable (<350 fmol/punch, ≥350-699 fmol/punch and ≥700 fmol/punch). 1,270 individuals were assessed for participation; n = 738 were potentially eligible and n = 450 were offered PrEP (PrEP uptake was 60.9%). Eligible but not enrolled individuals were younger, had lower HIV risk perception and had lower PrEP awareness. At week 4, 424 participants (of the 450 enrolled) had DBS TFV-DP concentrations, 94.1% in the protective range (≥350 fmol/punch, consistent with ≥2 pills per week), and 78% were in the highly protective range (≥700 fmol/punch, ≥4 pills per week). Participants with ≥12 years of schooling had 1.9 times the odds (95%CI 1.10-3.29) of a higher versus lower drug level than participants with <12 years of schooling. Condomless receptive anal intercourse in the prior 3 months was also associated with higher drug levels (adjusted OR = 1.78; 95% CI 1.08-2.94). The high uptake and early adherence indicate that PrEP for high-risk MSM and TGW can be successfully delivered in the context of the Brazilian Public Health System. Interventions to

  20. Interest rate pass-through in the Dominican Republic

    National Research Council Canada - National Science Library

    Grigoli, Francesco; Mota, José M

    2017-01-01

    ... rates, to eventually influence aggregate demand and inflation. This paper estimates the interest rate pass-through of the monetary policy rate to retail rates and explores asymmetries in the adjustment...

  1. Number of Migration Scenarios Passing through each HUC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Forest dwelling neotropical migratory birds require intact forested stopovers during migration. The number of paths that pass through a HUC highlight that huc's...

  2. Band pass filters. Citations from the NTIS data base

    Science.gov (United States)

    Reed, W. E.

    1980-04-01

    A bibliography containing 242 abstracts addressing the design, fabrication, characterization, and application of band pass filters is presented. Radiofrequency, digital, acoustic surface wave, and X-ray filters are included.

  3. NMFS Prioritization, Allocation & Scheduling System (NMFS Asset PASS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NMFS Asset PASS is a web-based enterprise application and ORACLE database that collects research platform requests. The first release initially focused on line...

  4. Chaotic jam and phase transition in traffic flow with passing.

    Science.gov (United States)

    Nagatani, T

    1999-08-01

    The lattice hydrodynamic model is presented to take into account the passing effect in one-dimensional traffic flow. When the passing constant gamma is small, the conventional jamming transition occurs between the uniform traffic and kink density wave flows. When passing constant gamma is larger than the critical value, the jamming transitions occur from the uniform traffic flow, through the chaotic density wave flow, to the kink density wave flow, with an increasing delay time. The chaotic region increases with passing constant gamma. The neutral stability line is derived from the linear stability analysis. The neutral stability line coincides with the transition line between the uniform traffic and density wave flows. The modified Korteweg-de Vries equation describing the kink jam is derived for small values of gamma by use of a nonlinear analysis.

  5. Number of Migration Scenarios Passing through each HUC (future)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Forest dwelling neotropical migratory birds require intact forested stopovers during migration. The number of paths that pass through a HUC highlight that huc's...

  6. Direct Deposit -- When Message Passing Meets Shared Memory

    Science.gov (United States)

    2000-05-19

    by H. Karl in [64]. The paper implements the pure DSM code, the pure message passing code and a few intermediate forms on the Charlotte DSM system [8...ASPLOS VI), pages 51–60, San Jose, October 1994. ACM. [64] H. Karl . Bridging the gap between distributed shared memory and message passing. Concurrency...pages 94 – 101, 1988. [73] P.N. Loewenstein and D.L. Dill. Verification of a multiprocessor cache protocol using simulation relations and higher-order

  7. Data Handover: Reconciling Message Passing and Shared Memory

    OpenAIRE

    Gustedt, Jens

    2004-01-01

    Data Handover (DHO) is a programming paradigm and interface that aims to handle data between parallel or distributed processes that mixes aspects of message passing and shared memory. It is designed to overcome the potential problems in terms of efficiency of both: (1) memory blowup and forced copies for message passing and (2) data consistency and latency problems for shared memory. Our approach attempts to be simple and easy to understand. It content...

  8. River Dart Weir and fish pass survey 1992

    OpenAIRE

    Maslin, M

    1992-01-01

    This is the River Dart, Weir and Fish Pass Survey 1992 report produced by the National Rivers Authority. It goes through the general condition of Weirs and fish passes to determine the extent of problems associated with the upstream and downstream migration of salmonids. It considers solutions where problems exist and investigates the exact use of the resource. It looks at the following Weirs: Totnes, Staverton, Hood, Kilbury, Buckfast, Holne, Mardle (River Mardle), Holybrook (Holybrook), ...

  9. Terrorismihirm sunnib muretsema kalleid mikrokiibiga passe / Andrus Karnau

    Index Scriptorium Estoniae

    Karnau, Andrus

    2005-01-01

    Alates 1. septembrist 2006 peavad kõik EL-i liikmesriigid hakkama väljastama mikrokiibiga varustatud passe, mille hinnaks võib kujuneda kuni 1000 krooni ja kehtivus lüheneb viiele aastale. Mikrokiip sisaldab inimese biomeetrilisi andmeid - esialgu vaid näokujutist, alates 2008. aastast näpujälgi ning hiljem ka andmeid silmaiirise ja juuksevärvi kohta. Lisa: Biomeetriline pass peidab intiimseid isikuandmeid. Kommenteerib Kohtuekspertiisi ja Kriminalistika Keskuse infojuht Aivar Pau

  10. Gestalt-like representations hijack Chunk-and-Pass processing.

    Science.gov (United States)

    Dumitru, Magda L

    2016-01-01

    Christiansen & Chater (C&C) make two related and somewhat contradictory claims, namely that the ever abstract language representations built during Chunk-and-Pass processing allow for ever greater interference from extra-linguistic information, and that it is nevertheless the language system that re-codes incoming information into abstract representations. I analyse these claims and discuss evidence suggesting that Gestalt-like representations hijack Chunk-and-Pass processing.

  11. BIOTECON diagnostics foodproof Listeria monocytogenes Detection Kit, 5' nuclease in combination with the foodproof ShortPrep II Kit.

    Science.gov (United States)

    Junge, Benjamin; Grönewald, Cordt; Berghof-Jäger, Kornelia

    2012-01-01

    A method was developed for the detection of Listeria monocytogenes in food. The method is based on real-time PCR using hydrolysis probes (5' Nuclease). This advanced PCR method was designed to reduce the time necessary to achieve results from PCR reactions and to enable the user to monitor the amplification of the PCR product simultaneously, in real-time. After DNA isolation using the BIOTECON foodproof ShortPrep II Kit designed for the rapid preparation of L. monocytogenes DNA for direct use in PCR, the real-time detection of L. monocytogenes DNA is carried out using the foodproof Listeria monocytogenes Detection Kit. The kit provides primers and hydrolysis probes for sequence-specific detection, convenient premixed reagents, and controls for reliable interpretation of results. For the internal comparison study, three different foods (soft cheese, coalfish, and smoked ham) were analyzed, chosen from the 15 food groups recommended by the AOAC Research Institute for detection of L. monocytogenes. From each food, 20 samples were inoculated with a low level (1-10 CFU/25 g) and 20 samples with a high level (10-50 CFU/25 g) of L. monocytogenes. Additionally, five nonspiked samples were prepared from each food. Depending on the matrix, the food samples were examined with the test kits and compared with the cultural methods according to the U.S. Food and Drug Administration's Bacteriological Analytical Manual or the U.S. Department of Agriculture/Food Safety and Inspection Service Microbiology Laboratory Guidebook.

  12. Has the ThinPrep method of cervical screening maintained its improvement over conventional smears in terms of specimen adequacy?

    LENUS (Irish Health Repository)

    Treacy, A

    2009-04-01

    Liquid-based cytology (LBC) has replaced conventional smear assessment in many centers over recent years. In our laboratory this transfer took place in 1999. At that time we performed a split sample study comparing the conventional method of cervical smear evaluation with the ThinPrep system. This split sample study identified a dramatic improvement in specimen adequacy with LBC. While 11% of conventional preparations were reported as unsatisfactory and almost 9% were reported as suboptimal, evaluation of the same cases using LBC saw this combined figure reduced to 2.3%. AIM: To evaluate whether this dramatic fall in unsatisfactory smears has been maintained with the use of LBC. The database for all smears reported for 2005 (100% LBC) was interrogated. The number of unsatisfactory reports was calculated. The reason for an unsatisfactory report was recorded for each case. The overall unsatisfactory rate was compared with that reported in the 1999 split sample study. A total of 41,312 smear tests were reported in 2005. 1,342 (3.25%) were reported as unsatisfactory. Our findings support the ongoing value of LBC in a routine cervical screening laboratory in terms of continuing to maintain a low rate of unsatisfactory smears.

  13. Preliminary study of a new, fully automated system for liquid-based cytology: the NovaPrep® processor system.

    Science.gov (United States)

    Esquivias López-Cuervo, Javier; Montalbán Beltran, Estanislao; Cuadros Lopez, Jose Luis; Alonso Castillo, Angeles; Nieto Sanchez, Teresa

    2011-01-01

    To evaluate a fully automated system for liquid-based cytology (LBC): the NovaPrep® Processor System (NPS), which is based on the new concept of double decantation, versus conventional cytology (CC), the gold standard for cytology. We performed a preliminary comparative study involving 1,129 female patients who underwent sampling for a Pap test; the sample was first smeared for CC and then, using the remaining specimen on the brush, for LBC with the NPS. The performances of CC and NPS were evaluated for accuracy and compared using the gold standard of a combination of one of the two methods of pathological cytology with screening for positive human papilloma virus, quantification of cells (normal and pathological), and improvement in the quality of samples and reading time. The results showed improvement in sensitivity (3.81% for CC vs. 4.52% for NPS) with a specificity superior to 90% for both, a markedly decreased number of unsatisfactory specimens, notably samples containing too many inflamed cells (7.4% for CC vs. 0.5% for NPS), and a shortening of the reading time, which was three times less using NPS. This preliminary study showed a gain in sensitivity, a drop in the number of unsatisfactory specimens and a reduction in reading time with NPS. The results achieved using this fully automated LBC procedure are very promising and will hopefully reduce the overall cost of cervical cancer screening in the future. Copyright © 2011 S. Karger AG, Basel.

  14. Protocol for an open-label, single-arm trial of HIV pre-exposure prophylaxis (PrEP) among people at high risk of HIV infection: the NSW Demonstration Project PRELUDE

    Science.gov (United States)

    Vaccher, S; Grulich, A; McAllister, J; Templeton, D J; Bloch, M; McNulty, A; Holden, J; Poynten, I M; Prestage, G; Zablotska, I

    2016-01-01

    Introduction Despite a number of HIV prevention strategies, the number of new HIV infections remains high. In Australia, over three-quarters of new HIV diagnoses are in gay and bisexual men (GBM). Pre-exposure prophylaxis (PrEP) has been shown to be effective at preventing new HIV infections in several randomised trials. The PRELUDE study aims to evaluate the implementation of PrEP in healthcare settings in New South Wales (NSW), Australia, among a sample of high-risk adults. Methods and analysis PRELUDE is an ongoing open-label, single-arm demonstration project, conducted in public and private clinics across NSW, Australia. Enrolment began in November 2014. The study is designed for 300 high-risk participants—mainly GBM and heterosexual women. Participants receive daily oral PrEP, composed of emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF), for up to 2.5 years. Quarterly study visits include testing for HIV and sexually transmitted infections (STIs), assessment of ongoing eligibility and side effects, and self-reported adherence. Following each study visit, online behavioural surveys are administered to collect information on medication adherence, risk behaviours and attitudes. Blood samples will be collected in a subset of patients 1, 6 and 12 months after PrEP initiation to measure FTC/TDF concentrations. Analyses using longitudinal regression models will focus on feasibility, adherence, safety, tolerability and effects of PrEP on behaviour. This study will inform PrEP policy and guide the implementation of PrEP in Australia in people at high risk of HIV. Ethics and dissemination The study will be conducted in accordance with the Declaration of Helsinki. All patients will provide written informed consent prior to participation in the study. Publications relating to each of the primary end points will be gradually released after 12 months of follow-up is complete. Trial registration number NCT02206555; Pre-results. PMID:27324719

  15. 2006 United States Army Corps of Engineers (USACE) Post Hurricane Wilma Lidar: Hurricane Pass to Big Hickory Pass, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data contained in these files contain hydrographic and topographic data collected by the CHARTS system along the west coast of Florida from Hurricane Pass to Big...

  16. Teachers in Class

    Science.gov (United States)

    Van Galen, Jane

    2008-01-01

    In this article, I argue for a closer read of the daily "class work" of teachers, as posited by Reay, 1998. In developing exploratory class portraits of four teachers who occupy distinctive social positions (two from working-class homes now teaching upper-middle-class children and two from upper-middle-class homes now teaching poor children), I…

  17. Error Comparison and Analysis of the Two-pass and Three-pass Approaches in Airborne D-InSAR

    OpenAIRE

    Li Yan-lei; Liang Xing-dong; Ding Chi-biao

    2013-01-01

    Airborne differential synthetic aperture radar interferometry (D-InSAR) is a kind of potential technology to survey the surface deformation. In this paper, the errors of two usually used modes of this technology, namely, two-pass and three-pass approaches, are compared and analyzed. In the analysis, all the errors are decomposed and sorted according to the principle of independence, and the coupling between motion error and other errors is considered. Based on the analysis, analytical express...

  18. Error Comparison and Analysis of the Two-pass and Three-pass Approaches in Airborne D-InSAR

    Directory of Open Access Journals (Sweden)

    Li Yan-lei

    2013-09-01

    Full Text Available Airborne differential synthetic aperture radar interferometry (D-InSAR is a kind of potential technology to survey the surface deformation. In this paper, the errors of two usually used modes of this technology, namely, two-pass and three-pass approaches, are compared and analyzed. In the analysis, all the errors are decomposed and sorted according to the principle of independence, and the coupling between motion error and other errors is considered. Based on the analysis, analytical expressions are derived for the deformation measurement errors in the two modes. The results demonstrate that when the amplitude of the motion error is small, the three-pass approach can reduce the requirement on the precision of the external topography data, so it distinctly outperforms the two-pass approach; when the amplitude of the motion error is large, high-precision topography data are needed in the three-pass approach, and as a result, its advantage over the two-pass approach is not distinct any more.

  19. 77 FR 31725 - Safety Zone; Belle Pass Dredge Operations, Belle Pass, Mile Marker 1.0 to Mile Marker (−0.2...

    Science.gov (United States)

    2012-05-30

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Belle Pass Dredge Operations, Belle Pass... operations in specified waters of Belle Pass, Port Fourchon, Louisiana. This action is necessary for the... pipelines along the Gulf Shoreline of Belle Pass. In addition to the dredging equipment described...

  20. Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk

    Directory of Open Access Journals (Sweden)

    James Wilton

    2016-06-01

    Full Text Available Introduction: Identifying appropriate pre-exposure prophylaxis (PrEP candidates is a challenge in planning for the safe and effective roll-out of this strategy. We explored the use of a validated HIV risk screening tool, HIV Incidence Risk Index for Men who have Sex with Men (HIRI-MSM, to identify “optimal” candidates among MSM testing at a busy sexual health clinic's community testing sites in Toronto, Canada. Methods: Between November 2014 and April 2015, we surveyed MSM undergoing anonymous HIV testing at community testing sites in Toronto, Canada, to quantify “optimal” candidates for scaling up PrEP roll-out, defined as being at high objective HIV risk (scoring ≥10 on the HIRI-MSM, perceiving oneself at moderate-to-high HIV risk and being willing to use PrEP. Cascades were constructed to identify barriers to broader PrEP uptake. The association between HIRI-MSM score and both willingness to use PrEP and perceived HIV risk were explored in separate multivariable logistic regression analyses. Results: Of 420 respondents, 64.4% were objectively at high risk, 52.5% were willing to use PrEP and 27.2% perceived themselves at moderate-to-high HIV risk. Only 16.4% were “optimal” candidates. Higher HIRI-MSM scores were positively associated with both willingness to use PrEP (aOR=1.7 per 10 score increase, 95%CI=1.3–2.2 and moderate-to-high perceived HIV risk (aOR=1.7 per 10 score increase, 95%CI=1.2–2.3. The proportion of men who were “optimal” candidates increased to 42.9% when the objective HIV risk cut-off was changed to top quartile of HIRI-MSM scores (≥26. In our full cascade, a very low proportion (5.3% of MSM surveyed could potentially benefit from PrEP under current conditions. The greatest barrier in the cascade was low perception of HIV risk among high-risk men, but considerable numbers were also lost in downstream cascade steps. Of men at high objective HIV risk, 68.3% did not perceive themselves to be at moderate

  1. Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk.

    Science.gov (United States)

    Wilton, James; Kain, Taylor; Fowler, Shawn; Hart, Trevor A; Grennan, Troy; Maxwell, John; Tan, Darrell Hs

    2016-01-01

    Identifying appropriate pre-exposure prophylaxis (PrEP) candidates is a challenge in planning for the safe and effective roll-out of this strategy. We explored the use of a validated HIV risk screening tool, HIV Incidence Risk Index for Men who have Sex with Men (HIRI-MSM), to identify "optimal" candidates among MSM testing at a busy sexual health clinic's community testing sites in Toronto, Canada. Between November 2014 and April 2015, we surveyed MSM undergoing anonymous HIV testing at community testing sites in Toronto, Canada, to quantify "optimal" candidates for scaling up PrEP roll-out, defined as being at high objective HIV risk (scoring ≥10 on the HIRI-MSM), perceiving oneself at moderate-to-high HIV risk and being willing to use PrEP. Cascades were constructed to identify barriers to broader PrEP uptake. The association between HIRI-MSM score and both willingness to use PrEP and perceived HIV risk were explored in separate multivariable logistic regression analyses. Of 420 respondents, 64.4% were objectively at high risk, 52.5% were willing to use PrEP and 27.2% perceived themselves at moderate-to-high HIV risk. Only 16.4% were "optimal" candidates. Higher HIRI-MSM scores were positively associated with both willingness to use PrEP (aOR=1.7 per 10 score increase, 95%CI=1.3-2.2) and moderate-to-high perceived HIV risk (aOR=1.7 per 10 score increase, 95%CI=1.2-2.3). The proportion of men who were "optimal" candidates increased to 42.9% when the objective HIV risk cut-off was changed to top quartile of HIRI-MSM scores (≥26). In our full cascade, a very low proportion (5.3%) of MSM surveyed could potentially benefit from PrEP under current conditions. The greatest barrier in the cascade was low perception of HIV risk among high-risk men, but considerable numbers were also lost in downstream cascade steps. Of men at high objective HIV risk, 68.3% did not perceive themselves to be at moderate-to-high HIV risk, 23.6% were unaware of PrEP, 40.1% were not

  2. RxClass

    Data.gov (United States)

    U.S. Department of Health & Human Services — The RxClass Browser is a web application for exploring and navigating through the class hierarchies to find the RxNorm drug members associated with each class....

  3. A prototype for the PASS Permanent All Sky Survey

    Science.gov (United States)

    Deeg, H. J.; Alonso, R.; Belmonte, J. A.; Horne, K.; Alsubai, K.; Collier Cameron, A.; Doyle, L. R.

    2004-10-01

    A prototype system for the Permanent All Sky Survey (PASS) project is presented. PASS is a continuous photometric survey of the entire celestial sphere with a high temporal resolution. Its major objectives are the detection of all giant-planet transits (with periods up to some weeks) across stars up to mag 10.5, and to deliver continuously photometry that is useful for the study of any variable stars. The prototype is based on CCD cameras with short focal length optics on a fixed mount. A small dome to house it at Teide Observatory, Tenerife, is currently being constructed. A placement at the antarctic Dome C is also being considered. The prototype will be used for a feasibility study of PASS, to define the best observing strategies, and to perform a detailed characterization of the capabilities and scope of the survey. Afterwards, a first partial sky surveying will be started with it. That first survey may be able to detect transiting planets during its first few hundred hours of operation. It will also deliver a data set around which software modules dealing with the various scientific objectives of PASS will be developed. The PASS project is still in its early phase and teams interested in specific scientific objectives, in providing technical expertise, or in participating with own observations are invited to collaborate.

  4. Validation of the G-PASS code : status report.

    Energy Technology Data Exchange (ETDEWEB)

    Vilim, R. B.; Nuclear Engineering Division

    2009-03-12

    Validation is the process of determining whether the models in a computer code can describe the important phenomena in applications of interest. This report describes past work and proposed future work for validating the Gas Plant Analyzer and System Simulator (G-PASS) code. The G-PASS code was developed for simulating gas reactor and chemical plant system behavior during operational transients and upset events. Results are presented comparing code properties, individual component models, and integrated system behavior against results from four other computer codes. Also identified are two experiment facilities nearing completion that will provide additional data for individual component and integrated system model validation. The main goal of the validation exercise is to ready a version of G-PASS for use as a tool in evaluating vendor designs and providing guidance to vendors on design directions in nuclear-hydrogen applications.

  5. Efficiently passing messages in distributed spiking neural network simulation.

    Science.gov (United States)

    Thibeault, Corey M; Minkovich, Kirill; O'Brien, Michael J; Harris, Frederick C; Srinivasa, Narayan

    2013-01-01

    Efficiently passing spiking messages in a neural model is an important aspect of high-performance simulation. As the scale of networks has increased so has the size of the computing systems required to simulate them. In addition, the information exchange of these resources has become more of an impediment to performance. In this paper we explore spike message passing using different mechanisms provided by the Message Passing Interface (MPI). A specific implementation, MVAPICH, designed for high-performance clusters with Infiniband hardware is employed. The focus is on providing information about these mechanisms for users of commodity high-performance spiking simulators. In addition, a novel hybrid method for spike exchange was implemented and benchmarked.

  6. Stable ring resonator with bidirectional passes through the gain medium

    Science.gov (United States)

    Paxton, Alan H.; Miller, Harold C.

    2014-03-01

    Ring resonators have unique properties that are sometimes desirable. Spatial hole burning is eliminated. Beam transformation, such as image rotation which may reduce the magnitude of certain aberrations, can be implemented in a traveling-wave region. There is a drawback, however. As usually constructed, a ring resonator has half as many passes through the gain medium as can be achieved with a standing-wave resonator. This may have a detrimental effect on laser efficiency. We have constructed a type of ring resonator that allows counterpropagating collinear passes through the gain medium, while there is also a section with a unidirectional beam. The resonator includes a polarizing beam splitter. The linear polarization is transformed to the orthogonal state by optical elements at the two ends of the region with counter-propagating beams. The beams passing through the gain medium in opposite directions are linearly polarized with orthogonal states.

  7. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2002-01-01

    We present a new transformation of call-by-value lambdaterms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Because it operates in one pass, it directly yields compact CPS programs that are comparable to what one would...... write by hand. Because it is compositional, it allows proofs by structural induction. Because it is first-order, reasoning about it does not require the use of a logical relation. This new CPS transformation connects two separate lines of research. It has already been used to state a new and simpler...... correctness proof of a direct-style transformation, and to develop a new and simpler CPS transformation of control-flow information....

  8. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2001-01-01

    We present a new transformation of λ-terms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Previous CPS transformations only enjoyed two out of the three properties of being first-order, one-pass, and compositional......, but the new transformation enjoys all three properties. It is proved correct directly by structural induction over source terms instead of indirectly with a colon translation, as in Plotkin's original proof. Similarly, it makes it possible to reason about CPS-transformed terms by structural induction over...... source terms, directly.The new CPS transformation connects separately published approaches to the CPS transformation. It has already been used to state a new and simpler correctness proof of a direct-style transformation, and to develop a new and simpler CPS transformation of control-flow information....

  9. A First-Order One-Pass CPS Transformation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2003-01-01

    We present a new transformation of λ-terms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and first-order. Previous CPS transformations only enjoyed two out of the three properties of being first-order, one-pass, and compositional......, but the new transformation enjoys all three properties. It is proved correct directly by structural induction over source terms instead of indirectly with a colon translation, as in Plotkin's original proof. Similarly, it makes it possible to reason about CPS-transformed terms by structural induction over...... source terms, directly.The new CPS transformation connects separately published approaches to the CPS transformation. It has already been used to state a new and simpler correctness proof of a direct-style transformation, and to develop a new and simpler CPS transformation of control-flow information....

  10. Efficiently passing messages in distributed spiking neural network simulation

    Directory of Open Access Journals (Sweden)

    Corey Michael Thibeault

    2013-06-01

    Full Text Available Efficiently passing spiking messages in a neural model is an important aspect of high-performance simulation. As the scale of networks has increased so has the size of the computing systems required to simulate them. In addition, the information exchange of these resources has become more of an impediment to performance. In this paper we explore spike message passing using different mechanisms provided by the Message Passing Interface (MPI. A specific implementation, MVAPICH, designed for high-performance clusters with Infiniband hardware is employed. The focus is on providing information about these mechanisms for users of commodity high-performance spiking simulators. In addition, a novel hybrid-method for spike exchange was implemented and benchmarked.

  11. Future-based Static Analysis of Message Passing Programs

    Directory of Open Access Journals (Sweden)

    Wytse Oortwijn

    2016-06-01

    Full Text Available Message passing is widely used in industry to develop programs consisting of several distributed communicating components. Developing functionally correct message passing software is very challenging due to the concurrent nature of message exchanges. Nonetheless, many safety-critical applications rely on the message passing paradigm, including air traffic control systems and emergency services, which makes proving their correctness crucial. We focus on the modular verification of MPI programs by statically verifying concrete Java code. We use separation logic to reason about local correctness and define abstractions of the communication protocol in the process algebra used by mCRL2. We call these abstractions futures as they predict how components will interact during program execution. We establish a provable link between futures and program code and analyse the abstract futures via model checking to prove global correctness. Finally, we verify a leader election protocol to demonstrate our approach.

  12. Etiologic factors related to unsatisfactory ThinPrep® cervical cytology: Evaluation and potential solutions to improve

    Directory of Open Access Journals (Sweden)

    Tatyana Kalinicheva

    2015-01-01

    Full Text Available Background: In cervical cytology, the unsatisfactory rates for ThinPrep (TP are slightly higher compared to SurePath. We examined various causes and explored potential for resolution of this discrepancy. Materials and Methods: Totally, 19,422 cases were reviewed and 1000 unsatisfactory specimens were selected and analyzed. 531 specimens were available for wash protocol. Out of 114 unsatisfactory specimens associated with atrophic cellular changes (ACC, 48 were resubmitted by provider and reevaluated. Results: Lubricant and lubricant-like debris/contamination (LUBE was the most common cause of unsatisfactory specimens (68%; 681/1000 followed by blood (7.5%; ACC only (without other interfering factors (2.4%; inflammation (3.0%; and combinations thereof (1.9%. 11.5% showed scant cellularity without an identifiable cause. 3.3% were virtually acellular. Wash protocol improved cellularity in 48% (256/531 of cases. However, only 29% (73/256 of those were satisfactory (with more than 5000 cells. Quantitative reduction in LUBE after wash protocol varied with different morphological subtypes. Interpretation patterns on satisfactory specimens after wash protocol were comparable to the results on selected cohort of specimens during the same study period. Out of 114 ACC, wash protocol was performed on 68 ACC specimens leading to satisfactory TP in 24% (16/68. Totally, 48 cases reported as unsatisfactory with ACC, were resubmitted by the providers between 2 weeks and 2 years. 44 (92% showed increased cellularity, out of which 52% (23/44 did not show ACC. Conclusion: LUBE was the most common cause of unsatisfactory TP in addition to interference by blood and association with atrophic changes. Knowing the morphological spectrum of LUBE would help to identify it as the cause of "unsatisfactory" TP. Communicating the cause of unsatisfactory TP such as LUBE, ACC, and blood would hint the provider to take appropriate precaution during submission of the repeat

  13. Flanking region variation of ForenSeq™ DNA Signature Prep Kit STR and SNP loci in Yavapai Native Americans.

    Science.gov (United States)

    Wendt, Frank R; King, Jonathan L; Novroski, Nicole M M; Churchill, Jennifer D; Ng, Jillian; Oldt, Robert F; McCulloh, Kelly L; Weise, Jessica A; Smith, David Glenn; Kanthaswamy, Sreetharan; Budowle, Bruce

    2017-02-27

    Massively parallel sequencing (MPS) offers advantages over current capillary electrophoresis-based analysis of short tandem repeat (STR) loci for human identification testing. In particular STR repeat motif sequence information can be obtained, thereby increasing the discrimination power of some loci. While sequence variation within the repeat region is observed relatively frequently in some of the commonly used STRs, there is an additional degree of variation found in the flanking regions adjacent to the repeat motif. Repeat motif and flanking region sequence variation have been described for major population groups, however, not for more isolated populations. Flanking region sequence variation in STR and single nucleotide polymorphism (SNP) loci in the Yavapai population was analyzed using the ForenSeq™ DNA Signature Prep Kit and STRait Razor v2s. Seven and 14 autosomal STRs and identity-informative single nucleotide polymorphisms (iiSNPs), respectively, had some degree of flanking region variation. Three and four of these identity-informative loci, respectively, showed ≥5% increase in expected heterozygosity. The combined length- and sequence-based random match probabilities (RMPs) for 27 autosomal STRs were 6.11×10(-26) and 2.79×10(-29), respectively. When combined with 94 iiSNPs (a subset of which became microhaplotypes) the combined RMP was 5.49×10(-63). Analysis of length-based and sequence-based autosomal STRs in STRUCTURE indicated that the Yavapai are most similar to the Hispanic population. While producing minimal increase in X- and Y-STR discrimination potential, access to flanking region data enabled identification of one novel X-STR and three Y-STR alleles relative to previous reports. Five ancestry-informative SNPs (aiSNPs) and two phenotype-informative SNPs (piSNPs) exhibited notable flanking region variation.

  14. Application of ThinPrep Bronchial Brushing Cytology in the Early Diagnosis of Lung Cancer: A Retrospective Study

    Science.gov (United States)

    Liu, Chaoying; Wen, Zhongmei; Li, Yang; Peng, Liping

    2014-01-01

    The majority of lung cancer patients are diagnosed at advanced stages of disease. This study evaluated the diagnostic value of ThinPrep (TP) bronchial brushing cytology in lung cancer. A total of 595 patients with suspicious lung cancer were enrolled in this study. The bronchial brushing samples were prepared by TP. The data were then compared to histology of lung tissue samples. Histologically, 479 of these 595 patients were diagnosed with lung cancer, including 223 cases of lung squamous cell carcinoma (SCC), 77 cases of lung adenocarcinoma (ADC), and 152 cases of small cell lung carcinoma (SCLC). The TP cytology revealed a total of 460 cases of lung cancer (including 232 SCCs, 91 ADCs, and 108 SCLCs). The TP cytological technique had 87.06% sensitivity and 62.93% specificity in the diagnosis of lung cancer. Specifically, TP cytology confirmed 195 of 223 SCCs, 47 of 77 ADCs, and 94 of 152 SCLCs. The TP cytology showed 87.44% sensitivity and 90.05% specificity for the diagnosis of SCC, with a Matthew's correlation coefficient (MCC) of 0.820; while the sensitivity was reduced to 61.04% and the specificity was 90.93% for the diagnosis of ADC, with a MCC of 0.464. For the diagnosis of SCLC, the sensitivity was 61.84% and the specificity was 96.84%, with a MCC of 0.648. Thus, this study demonstrated the usefulness of TP bronchial brushing cytology in the early diagnosis of lung cancer, especially the early stage of lung SCC. A prospective clinical trial will verify these data before being translated into the clinic. PMID:24759600

  15. Does Inflation Targeting Reduce Pass-Through Effect?

    Directory of Open Access Journals (Sweden)

    Murat Karagoz

    2012-10-01

    Full Text Available There is a common academic opinion that the dollarization caused by the increasing inflation rates, particularly in the emerging market economies since 1990s also increases the pass-through effects in such countries. Yet another opinion suggests that the decrease in the inflation rates thanks to inflation targeting causes a reversal in the dollarization and a decrease in the pass-through effect. The aim of this study is to evaluate both opinions for the selected emerging market economies. Six different emerging market economies have been tested via Panel VAR approach. The findings of the study seem to support the latter.

  16. Does Inflation Targeting Reduce Pass-Through Effect?

    Directory of Open Access Journals (Sweden)

    Murat Karagoz

    2016-02-01

    Full Text Available There is a common academic opinion that the dollarization caused by the increasing inflation rates, particularly in the emerging market economies since 1990s also increases the pass-through effects in such countries. Yet another opinion suggests that the decrease in the inflation rates thanks to inflation targeting causes a reversal in the dollarization and a decrease in the pass-through effect. The aim of this study is to evaluate both opinions for the selected emerging market economies. Six different emerging market economies have been tested via Panel VAR approach. The findings of the study seem to support the latter.

  17. Message-Passing Interface - Selected Topics and Best Practices

    OpenAIRE

    Janetzko, Florian

    2013-01-01

    The Message-Passing Interface (MPI) is a widely-used standard library for programming parallel applications using the distributed-memory model. In the first part of this talk we will give a short overview over concepts and properties of modern HPC hardware architectures as well as basic programming concepts. A brief introduction into a design strategy for parallel algorithms is presented.The focus of the second part will be on the Message-Passing interface. After a short overview over general...

  18. EXIT Chart Analysis of Binary Message-Passing Decoders

    DEFF Research Database (Denmark)

    Lechner, Gottfried; Pedersen, Troels; Kramer, Gerhard

    2007-01-01

    Binary message-passing decoders for LDPC codes are analyzed using EXIT charts. For the analysis, the variable node decoder performs all computations in the L-value domain. For the special case of a hard decision channel, this leads to the well know Gallager B algorithm, while the analysis can...... be extended to channels with larger output alphabets. By increasing the output alphabet from hard decisions to four symbols, a gain of more than 1.0 dB is achieved using optimized codes. For this code optimization, the mixing property of EXIT functions has to be modified to the case of binary message-passing...

  19. Loss of European silver eel passing a hydropower station

    DEFF Research Database (Denmark)

    Pedersen, Michael Ingemann; Jepsen, Niels; Aarestrup, Kim

    2012-01-01

    The aim of this study was to assess escapement success of silver eels, Anguilla anguilla (L.), in a lowland river while passing a reservoir and a hydropower station. It was hypothesized that passage success would be lowest at the hydropower station and that survival and migration speed would...... that within the study period, only 23% of the tagged eels reached the tidal limit, mainly due to difficulties in passing the hydropower dam. With such high loss-rates, the escapement goals set in the management plan cannot be achieved...

  20. Continuum Mechanical Modelling of Skin-pass Rolling

    DEFF Research Database (Denmark)

    Kijima, Hideo; Bay, Niels

    2007-01-01

    The special contact conditions in skin-pass rolling of steel strip is analyzed by studying plane strain upsetting of thin sheet with low reduction applying long narrow tools and dry friction conditions. An extended sticking region is estimated by an elasto-plastic FEM analysis of the plane strain...... upsetting. This sticking region causes a highly inhomogeneous elasto-plastic deformation with large influence of work-hardening and friction. A numerical analysis of skin-pass rolling shows the same contact conditions, i.e. an extended sticking region around the center of the contact zone. The calculated...

  1. Analysis and Design of Binary Message-Passing Decoders

    DEFF Research Database (Denmark)

    Lechner, Gottfried; Pedersen, Troels; Kramer, Gerhard

    2012-01-01

    Binary message-passing decoders for low-density parity-check (LDPC) codes are studied by using extrinsic information transfer (EXIT) charts. The channel delivers hard or soft decisions and the variable node decoder performs all computations in the L-value domain. A hard decision channel results...... message-passing decoders. Finally, it is shown that errors on cycles consisting only of degree two and three variable nodes cannot be corrected and a necessary and sufficient condition for the existence of a cycle-free subgraph is derived....

  2. Personal Access Satellite System (PASS) study. Fiscal year 1989 results

    Science.gov (United States)

    Sue, Miles K. (Editor)

    1990-01-01

    The Jet Propulsion Laboratory is exploring the potential and feasibility of a personal access satellite system (PASS) that will offer the user greater freedom and mobility than existing or currently planned communications systems. Studies performed in prior years resulted in a strawman design and the identification of technologies that are critical to the successful implementation of PASS. The study efforts in FY-89 were directed towards alternative design options with the objective of either improving the system performance or alleviating the constraints on the user terminal. The various design options and system issues studied this year and the results of the study are presented.

  3. Algorithm on robot soccer pass and shoot a ball

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Introduces of robot soccer's competition software of Harbin Institute of Technology(HIT), the con cept of running range and the method of calculating the running range for both the opponent and our teammates according to the distances Between the ball and robot soccers, and therefore the method of calculating the angle that the robot passes or shoots the ball according to the running ranges of both sides. And gives the examples of passing the ball when the ball's position is in the backcourt and shooting the ball when the ball's position is in the frontcourt.

  4. Magnetically Tunable Terahertz Switch and Band-Pass Filter

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hui; GUO Peng; CHANG Sheng-Jiang; YUAN Jing-He

    2008-01-01

    A novel design of a tunable terahertz switch and band-pass filter using liquid-crystal-filled photonic crystal waveguide is demonstrated. The effects of magnetic field on the photonic bandgaps and transmitting properties of a THz wave are investigated by using the plane wave expansion method and finite difference time domain method. The efficient photonic bandgap tuning is predicted such that the two-dimensional liquid-crystal-filled photonic crystal waveguide can serve as a switch and continuously tunable band-pass filter with controlling of the magnetic field.

  5. Delay Bound: Fractal Traffic Passes through Network Servers

    Directory of Open Access Journals (Sweden)

    Ming Li

    2013-01-01

    Full Text Available Delay analysis plays a role in real-time systems in computer communication networks. This paper gives our results in the aspect of delay analysis of fractal traffic passing through servers. There are three contributions presented in this paper. First, we will explain the reasons why conventional theory of queuing systems ceases in the general sense when arrival traffic is fractal. Then, we will propose a concise method of delay computation for hard real-time systems as shown in this paper. Finally, the delay computation of fractal traffic passing through severs is presented.

  6. Liquid-based cervical cytology using ThinPrep technology: weighing the pros and cons in a cost-effectiveness analysis.

    Science.gov (United States)

    de Bekker-Grob, Esther W; de Kok, Inge M C M; Bulten, Johan; van Rosmalen, Joost; Vedder, Judith E M; Arbyn, Marc; Klinkhamer, Paul J J M; Siebers, Albertus G; van Ballegooijen, Marjolein

    2012-08-01

    Cervical cancer screening with liquid-based cytology (LBC) has been developed as an alternative to the conventional Papanicolaou (CP) smear. Cost-effectiveness is one of the issues when evaluating LBC. Based on the results of a Dutch randomised controlled trial, we conducted cost-effectiveness threshold analyses to investigate under what circumstances manually screened ThinPrep LBC is cost-effective for screening. The MISCAN-Cervix microsimulation model and data from the Dutch NETHCON trial (including 89,784 women) were used to estimate the costs and (quality-adjusted) life years ((QA)LYs) gained for EU screening schedules, varying cost-effectiveness threshold values. Screening strategies were primary cytological screening with LBC or CP, and triage with human papillomavirus (HPV) testing. Threshold analyses showed that screening with LBC as a primary test can be cost-effective if LBC is less than 3.2 more costly per test than CP, if the sensitivity of LBC is at least 3-5 % points higher than CP, if the quality of life for women in triage follow-up is only 0.39, or if the rate of inadequate CP smears is at least 16.2 %. Regarding test characteristics and costs of LBC and CP, only under certain conditions will a change from CP to manually screened ThinPrep LBC be cost-effective. If none of these conditions are met, implementation of manually screened ThinPrep LBC seems warranted only if there are advantages other than cost-effectiveness. Further research is needed to establish whether other LBC systems will be more favorable with regard to cost-effectiveness.

  7. Effect of glacial acetic acid treatment of cervical ThinPrep specimens on HPV DNA detection with the cobas 4800 HPV test.

    Science.gov (United States)

    McMenamin, M; McKenna, M

    2013-10-01

    Cytology laboratories in the UK routinely treat unsatisfactory cervical liquid-based cytology (LBC) specimens with glacial acetic acid (GAA) to reduce the unsatisfactory rate. However, there is limited published data on the effect of GAA reprocessing on the molecular detection of human papillomavirus (HPV). The aim of this study was to assess the impact of GAA treatment of cervical ThinPrep(®) samples on HPV detection with the cobas(®) 4800 HPV Test (Roche Molecular Systems, Pleasanton, CA, USA). Residual ThinPrep samples (n = 121) were selected to provide a range of typical cytology results and enrich the study samples for HPV positivity. Specimens were equally split into two fractions: one part treated with 10% GAA and the other part left untreated. All samples were HPV tested using the cobas 4800 HPV Test, which simultaneously detects a total of 14 high-risk HPV (hrHPV) genotypes and individually identifies HPV16 and HPV18. The HPV positive/negative status of tested samples determined the level of agreement between treated and untreated fractions; one sample failed owing to detection of a clot by the instrument during pipetting, leaving 120 samples in the study. Statistical analysis was performed using an unweighted kappa. Analysis of overall HPV positivity showed 97.5% (117/120) agreement between the treated and untreated fractions with a kappa value of 0.95. There were 63/65 (96.9%) concordant HPV positive and 54/55 (98.2%) concordant HPV negative results. In addition to the three discordant results for overall HPV positivity, there were three HPV type-specific discrepancies giving a total of 114/120 concordant HPV results (95% agreement). Glacial acetic acid (GAA) treatment of cervical ThinPrep specimens does not have significant adverse affects on HPV detection with the cobas 4800 HPV Test. © 2013 John Wiley & Sons Ltd.

  8. A COMPARISON OF THE CLASS ACTION FOR DAMAGES IN THE AMERICAN JUDICIAL SYSTEM TO THE BRAZILIAN CLASS ACTION: THE REQUIREMENTS OF ADMISSIBILITY

    Directory of Open Access Journals (Sweden)

    A. P. Grinover

    2015-01-01

    Full Text Available After describing the class action for damages in the American judicial system, with the requisites of ‘prevalence’ and ‘superiority,’ the study passes to the examiner of the requirements of the admissibility of the Brazilian class action for damages, concluding on the existence of the same requisites, even in a civil law system.

  9. 78 FR 50405 - Amended Application for Presidential Permit; Northern Pass Transmission LLC

    Science.gov (United States)

    2013-08-19

    ... Application for Presidential Permit; Northern Pass Transmission LLC AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of Amended Application. SUMMARY: Northern Pass Transmission LLC (Northern Pass) has submitted an amended application for a Presidential permit to construct,...

  10. Zero transmission of HIV– “Still a long way to go” An Update on TasP : PrEP and PEP of HIV infection

    OpenAIRE

    Hiremath, Ravishekar N; Kamble, Manjunath; Bhalla, Sandeep; Ghodke, Sandhya; R K Chaudhary

    2014-01-01

    AIDS emerged as one of the most important public health issues of the late twentieth and early twenty-first centuries and is now one of the leading causes of global morbidity and mortality. The AIDS epidemic has prompted wide-reaching changes in public health, clinical practice, and scientific research, and has had a great impact upon societies throughout the world. This review article gives an in site into updates on TasP (Treatment as prevention), PrEP (pre-exposure prophylaxis) and PEP (Po...

  11. Lactacidemia en el umbral anaeróbico. Estudio en varones prepúberes de escuelas deportivas de fútbol.

    OpenAIRE

    2004-01-01

    RESUMEN El objetivo principal es conocer la conducta del lactato en sangre. Situación bibliográfica. Estructurada en cinco apartados: reservas energéticas y límites metabólicos, la regulación ácido-base, el metabolismo del lactato, el umbral anaeróbico y las diferencias existentes entre niños y adultos. Nos centramos en los menores niveles de lacticemia en los niños, el mayor umbral anaeróbico en prepúberes frente a adultos y las diferencias de adaptación del metabolismo glucolítico....

  12. Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP.

    Directory of Open Access Journals (Sweden)

    Albert Y Liu

    Full Text Available Pre-exposure prophylaxis (PrEP trials using tenofovir-based regimens have demonstrated that high levels of adherence are required to evaluate efficacy; the incorporation of objective biomarkers of adherence in trial design has been essential to interpretation, given the inaccuracy of self-report. Antiretroviral measurements in scalp hair have been useful as a marker of long-term exposure in the HIV treatment setting, and hair samples are relatively easy and inexpensive to collect, transport, and store for analysis. To evaluate the relationship between dose and tenofovir concentrations in hair, we examined the dose proportionality of tenofovir in hair in healthy, HIV-uninfected adults.A phase I, crossover pharmacokinetic study was performed in 24 HIV-negative adults receiving directly-observed oral tenofovir tablets administered 2, 4, and 7 doses/week for 6 weeks, with a ≥3-week break between periods. Small samples of hair were collected after each six-week period and analyzed for tenofovir concentrations. Geometric-mean-ratios compared levels between each pair of dosing conditions. Intensive plasma pharmacokinetic studies were performed during the daily-dosing period to calculate areas-under-the-time-concentration curves (AUCs.Over 90% of doses were observed per protocol. Median tenofovir concentrations in hair increased monotonically with dose. A log-linear relationship was seen between dose and hair levels, with an estimated 76% (95% CI 60-93% increase in hair level per 2-fold dose increase. Tenofovir plasma AUCs modestly predicted drug concentrations in hair.This study found a strong linear relationship between frequency of dosing and tenofovir levels in scalp hair. The analysis of quantitative drug levels in hair has the potential to improve adherence measurement in the PrEP field and may be helpful in determining exposure thresholds for protection and explaining failures in PrEP trials. Hair measures for adherence monitoring may also

  13. A Dynamic Continuation-Passing Style for Dynamic Delimited Continuations

    DEFF Research Database (Denmark)

    Biernacki, Dariusz; Danvy, Olivier; Millikin, Kevin Scott

    2005-01-01

    -passing style.' We show that the new machine operates more efficiently than the definitional one and that the notion of computation induced by the corresponding evaluator takes the form of a monad. We also present new examples and a new simulation of dynamic delimited continuations in terms of static ones....

  14. Single Pass Collider Memo: Gradient Perturbations of the SLC arc

    Energy Technology Data Exchange (ETDEWEB)

    Weng, W T

    2016-12-16

    As the beam passes through the arcs, the gradient it encounters at each magnet differs from the design value. This deviation may be in part random and in part systematic. In this note we make estimates of the effects to be expected from both kinds of errors.

  15. Polarization for the by-pass SLAC/PEP collider

    Energy Technology Data Exchange (ETDEWEB)

    Chao, A.W.

    1980-06-01

    It was suggested that one can collide the store e/sup +/ beam in PEP with the e/sup /minus// beam from SLAC to reach a center-of-mass energy higher than that achieved by the PEP colliding beams. Although the future of this PEP/SLAC collider is not yet certain, it is useful to first explore its physics possibilities. One possible version of the SLAC/PEP collider utilizes a by-pass at the interaction point; the stored beam is displaced vertically by a set of vertical bending magnets every time the linac beam arrives. One feature of this by-pass scheme that makes it attractive is that the amount of the vertical displacement of the by-pass can be chosen so that the spin polarization of the stored beam is made longitudinal at the point of interaction. In this note, we have studied the various depolarization effects of the stored e/sup +/ beam due to the perturbation of the by-pass magnets. 1 fig.

  16. Thin-disk laser multi-pass amplifier

    CERN Document Server

    Schuhmann, K; Graf, T; Hänsch, T W; Kirch, K; Kottmann, F; Pohl, R; Taqqu, D; Voß, A; Weichelt, B; Antognini, A

    2015-01-01

    In the context of the Lamb shift measurement in muonic helium we developed a thin-disk laser composed of a Q-switched oscillator and a multi-pass amplifier delivering pulses of 150 mJ at a pulse duration of 100 ns. Its peculiar requirements are stochastic trigger and short delay time (< 500 ns) between trigger and optical output. The concept of the thin-disk laser allows for energy and power scaling with high efficiency. However the single pass gain is small (about 1.2). Hence a multi-pass scheme with precise mode matching for large beam waists (w = 2 mm) is required. Instead of using the standard 4f design, we have developed a multi-pass amplifier with a beam propagation insensitive to thermal lens effects and misalignments. The beam propagation is equivalent to multiple roundtrips in an optically stable resonator. To support the propagation we used an array of 2 x 8 individually adjustable plane mirrors. Astigmatism has been minimized by a compact mirror placement. Precise alignment of the kinematic arra...

  17. Historical events: Single pass reactors and fuels fabrication

    Energy Technology Data Exchange (ETDEWEB)

    DeNeal, D.L.

    1970-04-10

    The intent of this report is to record, in one place, the significant historical events associated with the Single Pass Reactors from initial startup through December 1969. Significant events are chronologically listed in Section 1 and specific programs are summarized in Section 2.

  18. 33 CFR 401.42 - Passing hand lines.

    Science.gov (United States)

    2010-07-01

    ... behind the splice of the eye; (3) At Iroquois Lock and Lock 8, Welland Canal, both upbound and downbound... vessels of overall length in excess of 218 m in Locks 4 and 5, Welland Canal, shall secure the hand lien... lines. (a) At locks, hand lines shall be secured to the mooring lines and passed as follows: (1)...

  19. Iteration of transformation passes over attributed program trees

    NARCIS (Netherlands)

    Alblas, Henk

    1989-01-01

    Transformations of attributed program trees form an essential part of compiler optimizations. A strategy of repeatedly applying alternate attribute evaluation and tree transformation phases is discussed. An attribute evaluation phase consists of a sequence of passes over the tree. A tree transformat

  20. Morphologic Examination of the Stability of Pass Cavallo, Texas

    Science.gov (United States)

    2008-05-01

    inlet is approximately 145.7 m wider in 2007. Pass Cavallo Inlet Width Year 1860 1880 1900 1920 1940 1960 1980 2000 2020 In le t W id th , m 0 1000...Autónoma de México , San Antonio, TX, 171–189. Brouwer, R. L. 2006. Equilibrium and stability of a double inlet system. MS thesis, Department of

  1. Complete genes may pass from food to human blood

    DEFF Research Database (Denmark)

    Spisák, Sándor; Solymosi, Norbert; Ittzés, Péter

    2013-01-01

    Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded...

  2. Modelling of a one pass smoke tube boiler

    DEFF Research Database (Denmark)

    Karstensen, Claus M. S.; Sørensen, Kim

    2004-01-01

    A nonlinear state-space model with five states describing a one pass smoke tube boiler has been formulated. By means of mass- and energy-balance the model describes the dynamics of the Furnace, the Convection Zone and the Water/Steam Part and the three sub models are merged into an overall model...

  3. Message Passing on a Time-predictable Multicore Processor

    DEFF Research Database (Denmark)

    Sørensen, Rasmus Bo; Puffitsch, Wolfgang; Schoeberl, Martin

    2015-01-01

    Real-time systems need time-predictable computing platforms. For a multicore processor to be time-predictable, communication between processor cores needs to be time-predictable as well. This paper presents a time-predictable message-passing library for such a platform. We show how to build up...

  4. A New One-Pass Transformation into Monadic Normal Form

    DEFF Research Database (Denmark)

    Danvy, Olivier

    2003-01-01

    We present a translation from the call-by-value λ-calculus to monadic normal forms that includes short-cut boolean evaluation. The translation is higher-order, operates in one pass, duplicates no code, generates no chains of thunks, and is properly tail recursive. It makes a crucial use of symbolic...

  5. The ISO 5-pass authentication in χ-Spaces

    DEFF Research Database (Denmark)

    Cáccamo, Mario J.; Crazzolara, Federico; Milicia, Giuseppe

    2002-01-01

    We implement the ISO 5-pass authentication protocol and study its correctness using the χ-Space framework. χ-Spaces is a novel domain specific programming language designed for developing protocols and in particular security protocols. χ-Spaces programming language is an implementation of SPL...

  6. A Calculus of Communicating Systems with Label Passing

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik; Nielsen, Mogens

    Milner's Calculus of Communicating Systems (CCS) is extended with a mechanism for label passing - as an attempt to remedy some of the shortcomings of CCS w.r.t. dynamic change of agent interconnections. In the extended calculus, restriction is viewed formally as a binder, and the calculus allows...

  7. Establishing Pass/Fail Criteria for Bronchoscopy Performance

    DEFF Research Database (Denmark)

    Konge, Lars; Clementsen, Paul; Larsen, Klaus Richter;

    2012-01-01

    Background: Several tools have been created to assess competence in bronchoscopy. However, educational guidelines still use an arbitrary number of performed procedures to decide when basic competency is acquired. Objectives: The purpose of this study was to define pass/fail scores for two...

  8. The ISO 5-pass authentication in χ-Spaces

    DEFF Research Database (Denmark)

    Cáccamo, Mario J.; Crazzolara, Federico; Milicia, Giuseppe

    2002-01-01

    We implement the ISO 5-pass authentication protocol and study its correctness using the χ-Space framework. χ-Spaces is a novel domain specific programming language designed for developing protocols and in particular security protocols. χ-Spaces programming language is an implementation of SPL...

  9. Modelling of a one pass smoke tube boiler

    DEFF Research Database (Denmark)

    Karstensen, Claus M. S.; Sørensen, Kim

    2004-01-01

    A nonlinear state-space model with five states describing a one pass smoke tube boiler has been formulated. By means of mass- and energy-balance the model describes the dynamics of the Furnace, the Convection Zone and the Water/Steam Part and the three sub models are merged into an overall model...

  10. Protocol-Based Verification of Message-Passing Parallel Programs

    DEFF Research Database (Denmark)

    López-Acosta, Hugo-Andrés; Eduardo R. B. Marques, Eduardo R. B.; Martins, Francisco;

    2015-01-01

    a protocol language based on a dependent type system for message-passing parallel programs, which includes various communication operators, such as point-to-point messages, broadcast, reduce, array scatter and gather. For the verification of a program against a given protocol, the protocol is first...

  11. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  12. 36 CFR 72.37 - Pass-through funding.

    Science.gov (United States)

    2010-07-01

    ... is charged or is required for the services resulting through the Rehabilitation or Innovation grant... Section 72.37 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN... and Innovation § 72.37 Pass-through funding. Section 1006(a)(1) of the Act states that at the...

  13. On differential characteristic classes

    OpenAIRE

    Ho, Man-Ho

    2013-01-01

    In this paper we give explicit formulas of differential characteristic classes of principal $G$-bundles with connections and prove their expected properties. In particular, we obtain explicit formulas for differential Chern classes, differential Pontryagin classes and differential Euler class. Furthermore, we show that the differential Chern class is the unique natural transformation from (Simons-Sullivan) differential $K$-theory to (Cheeger-Simons) differential characters that is compatible ...

  14. Loosely coupled class families

    DEFF Research Database (Denmark)

    Ernst, Erik

    2001-01-01

    are expressed using virtual classes seem to be very tightly coupled internally. While clients have achieved the freedom to dynamically use one or the other family, it seems that any given family contains a xed set of classes and we will need to create an entire family of its own just in order to replace one......Families of mutually dependent classes that may be accessed polymor- phically provide an advanced tool for separation of concerns, in that it enables client code to use a group of instances of related classes safely without depending on the exact classes involved. However, class families which...... of the members with another class. This paper shows how to express class families in such a manner that the classes in these families can be used in many dierent combinations, still enabling family polymorphism and ensuring type safety....

  15. 77 FR 277 - Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P; Notice of Availability of the...

    Science.gov (United States)

    2012-01-04

    ... the liquefaction trains, flares, recycle boil-off gas compressors, potable water, service water, and... Availability of the Environmental Assessment for the Proposed Sabine Pass Liquefaction Project The staff of the... pipeline quality natural gas from the Creole Trail Pipeline, which interconnects with the SPLNG Terminal...

  16. Influence of welding passes on grain orientation - The example of a multi-pass V-weld

    Energy Technology Data Exchange (ETDEWEB)

    Ye, Jing, E-mail: yejing@skku.edu [School of Mechanical Engineering, Sungkyunkwan University, 300 Chunchun-dong, Jangan-gu 440-746 (Korea, Republic of); Moysan, Joseph, E-mail: joseph.moysan@univmed.fr [Aix-Marseille Universite, Laboratoire de Mecanique et d' Acoustique, site du LCND, Av. Gaston Berger, 13625 Aix en Provence (France); Song, Sung-Jin, E-mail: sjsong@skku.edu [School of Mechanical Engineering, Sungkyunkwan University, 300 Chunchun-dong, Jangan-gu 440-746 (Korea, Republic of); Kim, Hak-Joon, E-mail: hjkim21c@skku.edu [School of Mechanical Engineering, Sungkyunkwan University, 300 Chunchun-dong, Jangan-gu 440-746 (Korea, Republic of); Chassignole, Bertrand, E-mail: bertrand.chassignole@edf.fr [Departement MMC, EDF R and D, Site des Renardieres, 77818 Moret-sur-Loing (France); Gueudre, Cecile, E-mail: cecile.gueudre@univ-amu.fr [Aix-Marseille Universite, Laboratoire de Mecanique et d' Acoustique, site du LCND, Av. Gaston Berger, 13625 Aix en Provence (France); Dupond, Olivier, E-mail: olivier.dupond@edf.fr [Departement MMC, EDF R and D, Site des Renardieres, 77818 Moret-sur-Loing (France)

    2012-05-15

    The accurate modelling of grain orientations in a weld is important, when accurate ultrasonic test predictions of a welded assembly are needed. To achieve this objective, Electricite de France (EDF) and the Laboratoire de Caracterisation Non Destructive (LCND) have developed a dedicated code, which makes use of information recorded in the welding procedure. Among the welding parameters recorded, although the order in which the welding passes are made is of primary importance in the welding process, this information is not always well known or accurately described. In the present paper we analyse in greater detail the influence of the order of welding passes, using data obtained from the Centre for Advanced Non Destructive Evaluation (CANDE), derived from a dissimilar metal weld (DMW) with buttering. Comparisons are made using grain orientation measurements on a macrograph. - Highlights: Black-Right-Pointing-Pointer Influence of welding process on grain structure is studied using the MINA model. Black-Right-Pointing-Pointer For the first time the importance of a slight slope of the layers is evaluated. Black-Right-Pointing-Pointer Two orders of passes are compared for the modelling approach. Black-Right-Pointing-Pointer A major effect is observed due to a change in the order of passes.

  17. To Pass or Not to Pass: Modeling the Movement and Affordance Dynamics of a Pick and Place Task

    Directory of Open Access Journals (Sweden)

    Maurice Lamb

    2017-06-01

    Full Text Available Humans commonly engage in tasks that require or are made more efficient by coordinating with other humans. In this paper we introduce a task dynamics approach for modeling multi-agent interaction and decision making in a pick and place task where an agent must move an object from one location to another and decide whether to act alone or with a partner. Our aims were to identify and model (1 the affordance related dynamics that define an actor's choice to move an object alone or to pass it to their co-actor and (2 the trajectory dynamics of an actor's hand movements when moving to grasp, relocate, or pass the object. Using a virtual reality pick and place task, we demonstrate that both the decision to pass or not pass an object and the movement trajectories of the participants can be characterized in terms of a behavioral dynamics model. Simulations suggest that the proposed behavioral dynamics model exhibits features observed in human participants including hysteresis in decision making, non-straight line trajectories, and non-constant velocity profiles. The proposed model highlights how the same low-dimensional behavioral dynamics can operate to constrain multiple (and often nested levels of human activity and suggests that knowledge of what, when, where and how to move or act during pick and place behavior may be defined by these low dimensional task dynamics and, thus, can emerge spontaneously and in real-time with little a priori planning.

  18. ECRH scenarios with selective heating of trapped/passing electrons in the W7-X Stellarator

    Directory of Open Access Journals (Sweden)

    Marushchenko N.B.

    2015-01-01

    Full Text Available Using specific features of the magnetic equilibrium in the W7-X stellarator, the ECRH scenarios with combined X2 and X3 modes are discussed. The RF beams for operation with X2 and X3 modes need to be launched from low- and, via the remote steering launcher, high-field-side, respectivaly, in the different crosssections of the device where the maximum and minimum of the magnetic field located. The aim is to explore the possibility of selective heating of the different classes of electrons, passing and trapped, by changing direction of the beam for X3 or switching between the beams for X2 and X3 launched from the different ports. The numerical predictions for this kind of experiments in W7-X are performed by coupled transport and ray tracing codes

  19. ER@CEBAF: A test of 5-pass energy recovery at CEBAF

    Energy Technology Data Exchange (ETDEWEB)

    Bogacz, S. A. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Douglas, D. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Dubbe, C. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Hutton, A. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Michalski, T. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Pilat, F. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Roblin, Y. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Satogata, T. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Spata, M. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Tennant, C. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Tiefenback, M. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Ben-Zvi, I. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hao, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Korysko, P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Liu, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Minty, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Robert-Demolaize, G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Roser, T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Thieberger, P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tsoupas, N. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-06-06

    Jefferson Lab personnel have broad expertise in the design, commissioning, and operation of multiple energy recovery linacs (ERLs): the CEBAF Front-End Test (early 1990s), CEBAF-ER (2003), the IR Free Electron Laser (FEL) Demo, the IR FEL Upgrade, and the UV FEL Driver (1997-2014). Continued development of this core competency has led to this collaborative proposal to explore the forefronts of ERL technology at high energy in a unique expansion of CEBAF capability to a 5-pass ERL with negligible switchover time and programmatic impact to the CEBAF physics program. Such a capability would enable world-class studies of open issues in high-energy ERL beam dynamics that are relevant to future facilities such as electron-ion colliders (EICs). This proposal requests support from the CEBAF Program Advisory Committee to seek funding for hardware installation, and a prospective 12 days of beam time circa Fall 2018 for commissioning this high-energy multi-pass ERL experiment in CEBAF.

  20. Li-Ion Battery By-Pass Removal Qualification

    Science.gov (United States)

    Borthomieu, Y.; Pasquier, E.

    2005-05-01

    The reasons of the by-pass use on Space batteries is to avoid open circuit, short-circuit and dramatic performances drift on the power system. By-pass diodes are currently used in NiH2 batteries due to the high probability of open circuit at cell level. This probability is mainly linked to the possibility to have a hydrogen leak within the pressure vessel due to the high operating pressure (70 bars) that can induce cell open circuit. For the Lithium-Ion batteries, first items had bypass implemented by similarity, but: All the cell failure cases have been analyzed at battery level: - Cell Open circuit: In contrast to NiCd and NiH2 cells, Li-Ion cells can be put in parallel due to the fact the open circuit voltage (OCV) is linked to the State Of Charge (SOC). With cells in parallel, a battery open circuit failure can never be encountered even with a cell in open circuit. - Cell Short circuit: In case of cell short, the entire cells within the module will be shorted. - Cell capacity spread: If the capacities of cells in series are strongly diverging, the worst module limits the battery. In case the battery is no more able to deliver the requested power for which it was designed, the worst module has to be reversed. In reversal, a Li-Ion cell is self-shorted. So, the strong capacity decrease in one module leads to the short of this module. These three failure cases cover all the possible Li-Ion failure root causes. Considering these three events, the analysis demonstrates that the Li-Ion battery still functions in any case without any by-pass system because the design of the battery size always takes into account the loss of one module. Nevertheless, the by-pass removal should allow to: - Improve the battery reliability as each bypass unit represents a single - Reduce by at least 30 % of the total price of the battery, - Reduce significant weight at battery level, - Shorten the battery manufacturing lead time (at least 8 months for by-pass purchasing), - Avoid US

  1. Parallel Array Classes and Lightweight Sharing Mechanisms

    Directory of Open Access Journals (Sweden)

    Steve W. Otto

    1993-01-01

    Full Text Available We discuss a set of parallel array classes, MetaMP, for distributed-memory architectures. The classes are implemented in C++ and interface to the PVM or Intel NX message-passing systems. An array class implements a partitioned array as a set of objects distributed across the nodes – a "collective" object. Object methods hide the low-level message-passing and implement meaningful array operations. These include transparent guard strips (or sharing regions that support finite-difference stencils, reductions and multibroadcasts for support of pivoting and row operations, and interpolation/contraction operations for support of multigrid algorithms. The concept of guard strips is generalized to an object implementation of lightweight sharing mechanisms for finite element method (FEM and particle-in-cell (PIC algorithms. The sharing is accomplished through the mechanism of weak memory coherence and can be efficiently implemented. The price of the efficient implementation is memory usage and the need to explicitly specify the coherence operations. An intriguing feature of this programming model is that it maps well to both distributed-memory and shared-memory architectures.

  2. Improving Laboratory Efficiency by Automation of Preanalytic Processing of ThinPrep Specimens for Real-Time PCR High-Risk HPV Testing.

    Science.gov (United States)

    Barbieri, Daniela; Venturoli, Simona; Costa, Silvano; Landini, Maria Paola

    2016-06-01

    Cervical specimens collected in liquid-based cytology (LBC) media are the most common sample type used for high-risk human papillomavirus (HPV) testing. Since preanalytic steps such as vortexing and decapping vials, liquid transfer to a sample input tube with matching unique identifier, and recapping the original vials are required for processing LBC samples prior to running the Abbott RealTime High Risk HPV assay (Abbott, Wiesbaden, Germany), a full manual execution can be complicated, especially in high-throughput diagnostic contexts. Here, a custom-configured worktable setup for the Tecan Freedom EVO (Tecan, Männedorf, Switzerland) designed to automate and control preanalytic steps for ThinPrep (Hologic, Marlborough, MA) samples was used to evaluate the impact of automated versus manual preanalytics. Archival results for manual processing of 226 samples were compared with those obtained with the Tecan protocol, observing a very good overall concordance for final assay interpretation (95.6%). High overall agreement (100%) resulted also from retesting 99 samples by both the preanalytical protocols. High reproducibility was observed analyzing 23 randomly selected samples by automated preprocessing in triplicate. Hence, the new configuration of the Tecan platform translates the manual steps required to process ThinPrep specimens into automated operations, controls sample identification, and allows for saving hands-on time, while maintaining assay reproducibility and ensuring reliability of results, making it suitable for screening settings.

  3. Evaluation of the Illumina ForenSeq™ DNA Signature Prep Kit - MPS forensic application for the MiSeq FGx™ benchtop sequencer.

    Science.gov (United States)

    Xavier, Catarina; Parson, Walther

    2017-05-01

    Massively Parallel (Next Generation) Sequencing (MPS) technologies have recently been proven useful and successful in typing various markers relevant in forensic genetics, such as STRs, SNPs and mitochondrial genomes. Early studies investigated self-developed DNA libraries, commercially supplied kits are currently being made available to allow a smoother and gradual implementation of such technologies in forensic laboratories. The ForenSeq™ DNA Signature Prep Kit (Illumina, CA) is the first commercially available STR kit that can be used on the MiSeq FGx™ (Illumina, CA) benchtop high-throughput sequencer. This kit allows the simultaneous typing of 59 STRs and up to 172 SNPs in a single reaction and presents a short library preparation protocol adapted to contemporary forensic requirements. In this study, we evaluated the beta version of the ForenSeq DNA Signature Prep Kit MiSeq FGx system by investigating reproducibility, sensitivity, mixtures, concordance, casework-type and aDNA samples and found it to perform successfully, proving to be a robust method for future forensic applications. MPS brings the possibility of complex multiplexing, high sensitivity and sequencing resolution to forensics; however, the need for consensual directions on databasing, data storage and nomenclature must be taken into consideration. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Belief propagation decoding of quantum channels by passing quantum messages

    Science.gov (United States)

    Renes, Joseph M.

    2017-07-01

    The belief propagation (BP) algorithm is a powerful tool in a wide range of disciplines from statistical physics to machine learning to computational biology, and is ubiquitous in decoding classical error-correcting codes. The algorithm works by passing messages between nodes of the factor graph associated with the code and enables efficient decoding of the channel, in some cases even up to the Shannon capacity. Here we construct the first BP algorithm which passes quantum messages on the factor graph and is capable of decoding the classical-quantum channel with pure state outputs. This gives explicit decoding circuits whose number of gates is quadratic in the code length. We also show that this decoder can be modified to work with polar codes for the pure state channel and as part of a decoder for transmitting quantum information over the amplitude damping channel. These represent the first explicit capacity-achieving decoders for non-Pauli channels.

  5. Single pass sparsification in the streaming model with edge deletions

    CERN Document Server

    Goel, Ashish; Post, Ian

    2012-01-01

    In this paper we give a construction of cut sparsifiers of Benczur and Karger in the {\\em dynamic} streaming setting in a single pass over the data stream. Previous constructions either required multiple passes or were unable to handle edge deletions. We use $\\tilde{O}(1/\\e^2)$ time for each stream update and $\\tilde{O}(n/\\e^2)$ time to construct a sparsifier. Our $\\e$-sparsifiers have $O(n\\log^3 n/\\e^2)$ edges. The main tools behind our result are an application of sketching techniques of Ahn et al.[SODA'12] to estimate edge connectivity together with a novel application of sampling with limited independence and sparse recovery to produce the edges of the sparsifier.

  6. Testing the Turing Test — do Men Pass It?

    Science.gov (United States)

    Adam, Ruth; Hershberg, Uri; Schul, Yaacov; Solomon, Sorin

    We are fascinated by the idea of giving life to the inanimate. The fields of Artificial Life and Artificial Intelligence (AI) attempt to use a scientific approach to pursue this desire. The first steps on this approach hark back to Turing and his suggestion of an imitation game as an alternative answer to the question "can machines think?".1 To test his hypothesis, Turing formulated the Turing test1 to detect human behavior in computers. But how do humans pass such a test? What would you say if you would learn that they do not pass it well? What would it mean for our understanding of human behavior? What would it mean for our design of tests of the success of artificial life? We report below an experiment in which men consistently failed the Turing test.

  7. Beam dynamics simulation of a double pass proton linear accelerator

    Science.gov (United States)

    Hwang, Kilean; Qiang, Ji

    2017-04-01

    A recirculating superconducting linear accelerator with the advantage of both straight and circular accelerator has been demonstrated with relativistic electron beams. The acceleration concept of a recirculating proton beam was recently proposed [J. Qiang, Nucl. Instrum. Methods Phys. Res., Sect. A 795, 77 (2015, 10.1016/j.nima.2015.05.056)] and is currently under study. In order to further support the concept, the beam dynamics study on a recirculating proton linear accelerator has to be carried out. In this paper, we study the feasibility of a two-pass recirculating proton linear accelerator through the direct numerical beam dynamics design optimization and the start-to-end simulation. This study shows that the two-pass simultaneous focusing without particle losses is attainable including fully 3D space-charge effects through the entire accelerator system.

  8. PASS Syndrome: An IL-1-Driven Autoinflammatory Disease.

    Science.gov (United States)

    Leuenberger, Mathieu; Berner, Jeanne; Di Lucca, Julie; Fischer, Lara; Kaparos, Nikolaos; Conrad, Curdin; Hohl, Daniel; So, Alexander; Gilliet, Michel

    2016-01-01

    PASS syndrome is a rare inflammatory disease characterized by a chronic-relapsing course of pyoderma gangrenosum, acne vulgaris, hidradenitis suppurativa and ankylosing spondylitis. Here, we describe a case of a patient with spontaneously recurrent purulent skin lesions along with seronegative spondylarthritis consistent with the PASS syndrome. During his disease exacerbation, the patient displayed episodes of fever along with elevated serum levels of interleukin (IL)-1β. Skin lesions were characterized by sterile neutrophilic infiltrates and showed a rapid response to the IL-1 receptor antagonist anakinra (Kineret®) consistent with the autoinflammatory nature of this disease. However, unlike other autoinflammatory diseases such as PAPA and PAPASH, we did not find mutations in the gene PSTPIP1, raising the possibility that other specific mutations in the IL-1 pathway may be involved.

  9. Les représentations du passé

    Directory of Open Access Journals (Sweden)

    Mélissa S.-Morin

    2011-04-01

    Full Text Available Complétementaires et antagonistes, les relations entre histoire et mémoire en tant qu’appropriations du passé sont une question à la fois épistémique, politique et éthique. Elles sont intimement liées à la connaissance et aux usages sociaux du passé. Si la question ne date pas d’hier, elle a pris une importance nouvelle depuis les trente dernières années sous l’impulsion de ce que les historiens Pierre Nora, François Hartog et Allan Megill ont aptement et respectivement nommé le « moment-mémo...

  10. Model Checking Real-Time Value-Passing Systems

    Institute of Scientific and Technical Information of China (English)

    Jing Chen; Zio-Ning Cao

    2004-01-01

    In this paper,to model check real-time value-passing systems,a formal language Timed Symbolic Transition Graph and a logic system named Timed Predicate μ-Calculus are proposed.An algorithm is presented which is local in that it generates and investigates the reachable state space in top-down fashion and maintains the partition for time evaluations as coarse as possible while on-the-fly instantiating data variables.It can deal with not only data variables with finite value domain,but also the so called data independent variables with infinite value domain.To authors knowledge,this is the first algorithm for model checking timed systems containing value-passing features.

  11. Proposal of a sluice-type fish pass

    Directory of Open Access Journals (Sweden)

    Matthias A. Haselbauer

    Full Text Available One-dimensional design of fish passes often leads to an unsatisfying solution. The problems are due to insufficient, if not completely missing, collaboration between biologists and civil engineers. In the present paper, a new type of fish pass is presented. A labyrinth flux develops in a system of sequential sluices and baffles in between, which uncouple the supercritical flow of the single sluices. A series of biological, hydraulic and numerical experiments was carried out in order to investigate the optimum configuration in terms of geometric issues, regarding the biological needs and performances of organisms to be transported. Following this optimization, fish can control the prevailing flow conditions quite well. Because the air entrainment into the water is avoided, fish perception is not affected. A geometric extension regarding the needs of small fish, bottom fish, and macrozoobenthos decreases the selectivity and predation pressure on them.

  12. Regulation of information passing by synaptic transmission: a short review.

    Science.gov (United States)

    Di Maio, Vito

    2008-08-15

    The largest part of information passed among neurons in the brain occurs by the means of chemical synapses connecting the axons of presynaptic neurons to the dendritic tree of the postsynaptic ones. In the present paper, the most relevant open problems related to the mechanisms of control of the information passing among neurons by synaptic transmission will be shortly reviewed. The "cross talking" between synapses, their mutual interactions and the control of the information flow between different areas of the dendritic tree will be also considered. The threshold mechanism based on the "reversal potential" will be considered for its role in the control of information transfer among neurons and also for its contribution to the information flow among different areas of the dendritic tree and to the computational ability of the single neuron. The concept of "competition for plasticity" will be proposed as a mechanism of competition based on the synaptic activation time.

  13. Denoising Message Passing for X-ray Computed Tomography Reconstruction

    CERN Document Server

    Perelli, Alessandro; Can, Ali; Davies, Mike E

    2016-01-01

    X-ray Computed Tomography (CT) reconstruction from sparse number of views is becoming a powerful way to reduce either the radiation dose or the acquisition time in CT systems but still requires a huge computational time. This paper introduces an approximate Bayesian inference framework for CT reconstruction based on a family of denoising approximate message passing (DCT-AMP) algorithms able to improve both the convergence speed and the reconstruction quality. Approximate Message Passing for Compressed Sensing has been extensively analysed for random linear measurements but there are still not clear solutions on how AMP should be modified and how it performs with real world problems. In particular to overcome the convergence issues of DCT-AMP with structured measurement matrices, we propose a disjoint preconditioned version of the algorithm tailored for both the geometric system model and the noise model. In addition the Bayesian DCT-AMP formulation allows to measure how the current estimate is close to the pr...

  14. What We Have Learned about Class Size Reduction in California. Capstone Report.

    Science.gov (United States)

    Bohrnstedt, George W., Ed.; Stecher, Brian M., Ed.

    This final report on the California Class Size Reduction (CSR) initiative summarizes findings from three earlier reports dating back to 1997. Chapter 1 recaps the history of California's CSR initiative and includes a discussion of what state leaders' expectations were when CSR was passed. The chapter also describes research on class-size reduction…

  15. Compressive Imaging via Approximate Message Passing with Image Denoising

    OpenAIRE

    Tan, Jin; Ma, Yanting; Baron, Dror

    2014-01-01

    We consider compressive imaging problems, where images are reconstructed from a reduced number of linear measurements. Our objective is to improve over existing compressive imaging algorithms in terms of both reconstruction error and runtime. To pursue our objective, we propose compressive imaging algorithms that employ the approximate message passing (AMP) framework. AMP is an iterative signal reconstruction algorithm that performs scalar denoising at each iteration; in order for AMP to reco...

  16. Verification-Based Interval-Passing Algorithm for Compressed Sensing

    OpenAIRE

    Wu, Xiaofu; Yang, Zhen

    2013-01-01

    We propose a verification-based Interval-Passing (IP) algorithm for iteratively reconstruction of nonnegative sparse signals using parity check matrices of low-density parity check (LDPC) codes as measurement matrices. The proposed algorithm can be considered as an improved IP algorithm by further incorporation of the mechanism of verification algorithm. It is proved that the proposed algorithm performs always better than either the IP algorithm or the verification algorithm. Simulation resul...

  17. An adaptive algorithm for pass adaptation in plate rolling

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new algorithm for pass adaptation in plate rolling is developed to improve thickness accuracy of plate products. The feature of the algorithm is that it uses the measured data rather than the schedule calculated data in adaptation, which leads to notable improvementin prediction accuracy of the rolling parameters and thickness accuracy of products can be improved accordingly. Results show that this adaptive algorithm is effective in practice.

  18. An adaptive algorithm for pass adaptation in plate rolling

    Institute of Scientific and Technical Information of China (English)

    ZhichunMu; WeimingLi; 等

    2002-01-01

    A new algorithm for pass adaptation in plate rolling is developed to improve thickness accuracy of plate products.The feature of the algorithm is that it uses the measured data rather than the schedule calculated data in adaptation,which leads to notable improvement in prediction accuracy of the rolling parmeters and thickness accuracy of products can be improved accordingly.Results show that this adaptive algorithm is effective in practice.

  19. Family networks and material inheritances: passing on the testimony

    Directory of Open Access Journals (Sweden)

    Marta Faria Patrão

    2012-11-01

    Full Text Available This study aims to deepen the knowledge about the process of material inheritance transmission in later life families, by studying the profiles of transmission of material legacy (what is transmitted, to whom, when and how?, the dynamics of support between donors and heirs and their influence on family satisfaction. Main results suggest that material inheritance is a normative process in later life families, involving the reorganization of the management of families’ material property and its transmission (passing on financial testimony.

  20. Quantitative modelling in cognitive ergonomics: predicting signals passed at danger

    OpenAIRE

    Moray, Neville; Groeger, John; Stanton, Neville

    2016-01-01

    This paper shows how to combine field observations, experimental data, and mathematical modeling to produce quantitative explanations and predictions of complex events in human-machine interaction. As an example we consider a major railway accident. In 1999 a commuter train passed a red signal near Ladbroke Grove, UK, into the path of an express. We use the Public Inquiry Report, "black box" data, and accident and engineering reports, to construct a case history of the accident. We show how t...

  1. Physics/computer science. Passing messages between disciplines.

    Science.gov (United States)

    Mézard, Marc

    2003-09-19

    Problems in computer science, such as error correction in information transfer and "satisfiability" in optimization, show phase transitions familiar from solid-state physics. In his Perspective, Mézard explains how recent advances in these three fields originate in similar "message passing" procedures. The exchange of elaborate messages between different variables and constraints, used in the study of phase transitions in physical systems, helps to make error correction and satisfiability codes more efficient.

  2. Interest Rate Pass-through in Sri Lanka

    OpenAIRE

    Amarasekara, Chandranath

    2005-01-01

    The Central Bank of Sri Lanka has increasingly been relying on interest rates as the instrument for conducting monetary policy. Changes to the key monetary policy variables, the Repo and the Reverse Repo rates, are initially expected to be reflected in the OMO rates and the call money market rates, before being passedthrough to commercial bank retail interest rates. It is important to obtain a good understanding of the speed and magnitude of the interest rate pass-through to make timely monet...

  3. Crossing and Passing: Discursive Borders in Off Shoring

    Directory of Open Access Journals (Sweden)

    Sanae Elmoudden

    2009-01-01

    Full Text Available As a term in popular discourse, globalisation marks a celebrated openness of global spaces. Critics of globalisation argue that a global economy creates borders that are more discursive than territorial. A current challenge to globalisation scholars is reaching an understanding of how the many configurations of context, space, time and place created by globalisation result in new ways of organizing space and identity. Based on rich ethnographic data from an off shore call centre in Morocco and informed by interdisciplinary research on space, this paper bridges the links between territorial and discursive borders in the global social network of off shoring. Metaphorical spaces come about when dynamic configurations of contexts at territorial borders relate or are made to relate. Call centre agents use metaphorical spaces to fix the meaning of space. In this article, I identify two different metaphorical spaces: crossing and passing that help agents organize and negotiate their spaces and subsequently their identities and power relations. I suggest that agents negotiate place through space. This crossing takes place as they imbricate the Moroccan context of “L’hrig” within the continuum of the call centre. I also suggest that agents negotiate space through place. This passing occurs via the imbrication of metaphorical space of polyvalence. Crossing and passing inscribe not only a literal meaning of “movement” and “disembodiment”, but also the nuanced meaning of “movement and staying” and “disembodiment and re-embodiment” in a place where conjunctions of space, time, place and context collide. The creation of metaphorical spaces of crossing and passing suggests modification of our understanding of diaspora: attaining the diasporic space can no longer depend on physical borders alone; it must also rely on discursive borders.

  4. The Project of Medical IR Materials Passed Argumentation

    Institute of Scientific and Technical Information of China (English)

    Qian Bozhang

    2012-01-01

    Research Project on the Key Technologies for Medical IR Materials and Products declared by Puyang Linshi Chemical New Materials Co., Ltd. passed the expert argumentation organized by Henan Science and Technology Department in April 2012, and was listed in the significant scientific and technological special projects of Henan Province. This project, with the re- search basis of medical IR development, will form the production capacity of 150 million pairs of medical IR surgical gloves after achieving the designed capacity.

  5. PRCR Classes and Activities

    Data.gov (United States)

    Town of Cary, North Carolina — This data is specific to Parks and Recreation classes, workshops, and activities within the course catalog. It contains an entry for upcoming classes.*This data set...

  6. Class 1 Areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — A "Class 1" area is a geographic area recognized by the EPA as being of the highest environmental quality and requiring maximum protection. Class I areas are areas...

  7. Doodling in Math Class

    National Research Council Canada - National Science Library

    Arkenberg, Rebecca

    2013-01-01

      Arkenberg reviews Doodling in Math Class, an Internet resource available at www.youtube.com. Both math and art teachers have recommended the series of YouTube videos "Doodling in Math Class with Vihart...

  8. Re-evaluating the NCLEX-RN passing standard.

    Science.gov (United States)

    O'Neill, Thomas R; Marks, Casey M; Reynolds, Michelle

    2005-01-01

    Setting passing standards is a critical component of the NCLEX examination process. This research was conducted to provide sufficient information to the National Council of State Boards of Nursing's (NCSBN) Board of Directors to,make a decision regarding the passing standard of the NCLEX-RN. This article illustrates the standard setting process that NCSBN uses. Surveys of educators and employers, a modified Angoff procedure, the Beuk compromise, and global assessments by content experts were methods used. The Rasch model and a presumed ability distribution were used as the framework to integrate these diverse perspectives regarding minimal competence. The revised passing standard was -0.28 logits. For many of the minimal competence estimates, the author did not have authorization to release the information. In those instances, estimates and results were fabricated to be similar to the actual results, yet different enough as to not disclose confidential information. The fabricated results are clearly marked. In conclusion, a variety of approaches, sources, and perspectives are necessary for the establishment of fair and appropriate standards on the NCLEX-RN.

  9. Feedback Message Passing for Inference in Gaussian Graphical Models

    CERN Document Server

    Liu, Ying; Anandkumar, Animashree; Willsky, Alan S

    2011-01-01

    While loopy belief propagation (LBP) performs reasonably well for inference in some Gaussian graphical models with cycles, its performance is unsatisfactory for many others. In particular for some models LBP does not converge, and in general when it does converge, the computed variances are incorrect (except for cycle-free graphs for which belief propagation (BP) is non-iterative and exact). In this paper we propose {\\em feedback message passing} (FMP), a message-passing algorithm that makes use of a special set of vertices (called a {\\em feedback vertex set} or {\\em FVS}) whose removal results in a cycle-free graph. In FMP, standard BP is employed several times on the cycle-free subgraph excluding the FVS while a special message-passing scheme is used for the nodes in the FVS. The computational complexity of exact inference is $O(k^2n)$, where $k$ is the number of feedback nodes, and $n$ is the total number of nodes. When the size of the FVS is very large, FMP is intractable. Hence we propose {\\em approximat...

  10. A Prototype for the PASS Permanent All Sky Survey

    CERN Document Server

    Deeg, H J; Belmonte, J A; Horne, K; Alsubai, K; Cameron, A C; Doyle, L R; Horne, Keith

    2004-01-01

    A prototype system for the Permanent All Sky Survey (PASS) project is presented. PASS is a continuous photometric survey of the entire celestial sphere with a high temporal resolution. Its major objectives are the detection of all giant-planet transits (with periods up to some weeks) across stars up to mag 10.5, and to deliver continuously photometry that is useful for the study of any variable stars. The prototype is based on CCD cameras with short focal length optics on a fixed mount. A small dome to house it at Teide Observatory, Tenerife, is currently being constructed. A placement at the antarctic Dome C is also being considered. The prototype will be used for a feasibility study of PASS, to define the best observing strategies, and to perform a detailed characterization of the capabilities and scope of the survey. Afterwards, a first partial sky surveying will be started with it. That first survey may be able to detect transiting planets during its first few hundred hours of operation. It will also deli...

  11. An Improved Three-Weight Message-Passing Algorithm

    CERN Document Server

    Derbinsky, Nate; Elser, Veit; Yedidia, Jonathan S

    2013-01-01

    We describe how the powerful "Divide and Concur" algorithm for constraint satisfaction can be derived as a special case of a message-passing version of the Alternating Direction Method of Multipliers (ADMM) algorithm for convex optimization, and introduce an improved message-passing algorithm based on ADMM/DC by introducing three distinct weights for messages, with "certain" and "no opinion" weights, as well as the standard weight used in ADMM/DC. The "certain" messages allow our improved algorithm to implement constraint propagation as a special case, while the "no opinion" messages speed convergence for some problems by making the algorithm focus only on active constraints. We describe how our three-weight version of ADMM/DC can give greatly improved performance for non-convex problems such as circle packing and solving large Sudoku puzzles, while retaining the exact performance of ADMM for convex problems. We also describe the advantages of our algorithm compared to other message-passing algorithms based u...

  12. 75 FR 74029 - Sabine Pass LNG, L.P.; Notice of Application

    Science.gov (United States)

    2010-11-30

    ... Energy Regulatory Commission Sabine Pass LNG, L.P.; Notice of Application November 22, 2010. Take notice that on November 12, 2010, Sabine Pass LNG, L.P. (Sabine Pass), 700 Milam Street, Suite 800, Houston... a redundant high pressure boil off gas compressor at its existing Sabine Pass LNG Terminal,...

  13. 40 CFR 205.171-8 - Passing or failing under SEA.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Passing or failing under SEA. 205.171... Passing or failing under SEA. (a) A failing exhaust system is one which, when installed on any motorcycle... equal to the number in Column A, the sample passes. (c) Pass or failure of a SEA takes place when...

  14. 34 CFR 300.198 - Continuation of a by-pass.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Continuation of a by-pass. 300.198 Section 300.198... CHILDREN WITH DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.198 Continuation of a by-pass. The Secretary continues a by-pass until the Secretary determines that the SEA, LEA...

  15. 34 CFR 300.192 - Notice of intent to implement a by-pass.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Notice of intent to implement a by-pass. 300.192... EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.192 Notice of intent to implement a by-pass. (a) Before taking any final action to implement a by-pass,...

  16. 20 CFR 416.1226 - What is a plan to achieve self-support (PASS)?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What is a plan to achieve self-support (PASS... self-support (PASS)? (a) A PASS must— (1) Be designed especially for you; (2) Be in writing; (3) Be...: A Substantial Reduction Exists. Your SSI monthly payment amount is $101 and your PASS...

  17. 20 CFR 416.1181 - What is a plan to achieve self-support (PASS)?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What is a plan to achieve self-support (PASS... Self-Support § 416.1181 What is a plan to achieve self-support (PASS)? (a) A PASS must— (1) Be designed... Exists. Your SSI monthly payment amount is $101 and your PASS employment goal earnings will reduce...

  18. 34 CFR 300.191 - Provisions for services under a by-pass.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Provisions for services under a by-pass. 300.191... EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.191 Provisions for services under a by-pass. (a) Before implementing a by-pass, the Secretary consults...

  19. 26 CFR 301.6223(h)-1 - Responsibilities of pass-thru partner.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Responsibilities of pass-thru partner. 301.6223... Responsibilities of pass-thru partner. (a) In general. The pass-thru partner shall, within 30 days of receiving... tax matters partner, or another pass-thru partner, forward a copy of that notice or information to...

  20. 33 CFR 80.840 - Sabine Pass, TX to Galveston, TX.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sabine Pass, TX to Galveston, TX... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.840 Sabine Pass, TX to Galveston, TX. (a) A line drawn from the Sabine Pass East Jetty Light to the seaward end of the Sabine Pass...

  1. A Virtual Class Calculus

    DEFF Research Database (Denmark)

    Ernst, Erik; Ostermann, Klaus; Cook, William Randall

    2006-01-01

    model for virtual classes has been a long-standing open question. This paper presents a virtual class calculus, vc, that captures the essence of virtual classes in these full-fledged programming languages. The key contributions of the paper are a formalization of the dynamic and static semantics of vc...

  2. Education and Class.

    Science.gov (United States)

    Van Galen, Jane A.

    2000-01-01

    The working class is nearly invisible in multicultural education literature. Examines the possibilities of a more careful foregrounding of the complexities of social class in shaping life chances, focusing on the educational experiences of working class students and discussing the poor in order to promote understanding of the potential of teacher…

  3. Class `E` protective headwear: electric arc exposure

    Energy Technology Data Exchange (ETDEWEB)

    Jones, E.

    1997-04-01

    A series of tests were conducted using electric arcs under laboratory conditions to determine what, if any, damages can be inflicted upon class `E` hard hats. Ten hard hats were subjected to different levels of arc exposure to see if the hat would ignite, melt, drip, stick to the head, etc. It was noted that there is no standard on hard hat exposure to an electric arc. It was recommended that the CSA committee revise the protective headwear standard to include a requirement for flame/arc resistance, including specification of pass/fail criteria. 1 tab., 3 figs.

  4. Do single-sex classes affect exam scores? An experiment in a coeducational university

    OpenAIRE

    2013-01-01

    We examine the effect of single-sex classes on the pass rates, grades, and course choices of students in a coeducational university. We randomly assign students to all-female, all-male, and coed classes and, therefore, get around the selection issues present in other studies on single-sex education. We find that one hour a week of single-sex education benefits females: females are 7% more likely to pass their first year courses and score 10% higher in their required second year classes than t...

  5. Do Single-Sex Classes Affect Achievement? A Study in a Coeducational University

    OpenAIRE

    2013-01-01

    We examine the effect of single-sex classes on the pass rates, grades, and course choices of students in a coeducational university. We randomly assign students to all-female, all-male, and coed classes and, therefore, get around the selection issues present in other studies on single-sex education. We find that one hour a week of single-sex education benefits females: females are 7.5% more likely to pass their first year courses and score 10% higher in their required second year classes than...

  6. Research on Using PASS System in Clinical Pharmacology Teaching%PASS系统在临床药理学教学中的应用探索

    Institute of Scientific and Technical Information of China (English)

    雷力力; 王凤芝; 季方茹; 荆洪英; 李艳翠

    2011-01-01

    目的 探索临床药理学教学新的方法和形式.方法 在循环系统、消化系统、呼吸系统用药为主,理论课教学中对部分学生引进并应用PASS系统软件,同时以同年级的其它学生为对照.结果 实验班较对照班的成绩平均高出7分,实验班的合格率高出对照班2倍之多.PASS系统的应用有助于培养学生和提高在自学、分析问题和解决问题等多方面能力,为学生将来进入临床合理用药奠定了基础.结论 临床药理学的教学引进PASS系统软件可行,值得推广使用.%Objective To find a better method and style of clinical pharm acology teaching . Methods In theory course teachig of circulatory system ,digestive system and respiratory system ,the teaching method of applying PASS softw are system was used to teach apart of students and compared with the students those who without applying PASS softw are system in the same grade . Results The average score of experim ental class was seven points more than comparative class. The pass rate of experimental class was 2 times higher than comparative class. T he method of applying PASS softw are system contributes to improve student's self-educated ability, analyzing and abilities of solving problem . Conclusion It is feasible to apply PASS system in clinical pharmacology teaching .

  7. Numerical analysis of gain and noise figure in different configurations of single-pass and double-pass EDFA

    Science.gov (United States)

    Parali, Ufuk; Pınar, Cahit

    2016-04-01

    In this study our main objective is to design new Erbium-doped fiber amplifier (EDFA) configurations to obtain higher gain and lower noise figure (NF) values using an input signal -35 dBm at the wavelength of 1550 nm and the pump power 14 mW at the wavelength of 1480 nm. Utilizing Giles and Desurvire model, we proposed miscellaneous Single Pass (SP) and Double Pass (DP) EDFA configurations different in the means of pump signal direction where the two level system model equations are solved numerically in Matlab. The physical properties of the simulated EDFA configurations such as gain, noise factor, population density and amplified spontaneous emission were studied under various pumping directions.

  8. Analysis of CAB/UTIL & IFE/PASS SEAT Switch%浅谈CAB/UTIL和IFE/PASS SEAT电门

    Institute of Scientific and Technical Information of China (English)

    郭佳

    2015-01-01

    B737NG飞机P5-13电源面板存在两种构型,“CAB/UTIL”和“IFE/PASS SEAT”属于新构型中的两个电门,本文在结合手册与实际现象的基础上,分析了这两个电门的功用,避免在将来的排故过程中走弯路。%There are two configurations of B737NG aircraft P5-13 power supply panel, the"CAB/UTIL" and"IFE/PASS SEAT"belong to the two switches in the new configuration, based on the combination of manual and actual phenomena, this paper analyzes the function of these switches, to avoid detours during troubleshooting in the future.

  9. Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men.

    Science.gov (United States)

    Underhill, Kristen; Morrow, Kathleen M; Colleran, Christopher; Calabrese, Sarah K; Operario, Don; Salovey, Peter; Mayer, Kenneth H

    2016-07-01

    We investigated message comprehension and message framing preferences for communicating about PrEP efficacy with US MSM. We conducted eight focus groups (n = 38) and n = 56 individual interviews with MSM in Providence, RI. Facilitators probed comprehension, credibility, and acceptability of efficacy messages, including percentages, non-numerical paraphrases, efficacy ranges versus point estimates, and success- versus failure-framed messages. Our findings indicated a range of comprehension and operational understandings of efficacy messages. Participants tended to prefer percentage-based and success-framed messages, although preferences varied for communicating about efficacy using a single percentage versus a range. Participants reported uncertainty about how to interpret numerical estimates, and many questioned whether trial results would predict personal effectiveness. These results suggest that providers and researchers implementing PrEP may face challenges in communicating with users about efficacy. Efforts to educate MSM about PrEP should incorporate percentage-based information, and message framing decisions may influence message credibility and overall PrEP acceptability.

  10. Persian Preposition Classes

    Directory of Open Access Journals (Sweden)

    Marina Pantcheva

    2007-01-01

    Full Text Available In this paper I present the prepositional system in Persian. I show that Persian prepositions can be divided into three classes (Class 1, Class 2a and Class 2b which exhibit distinct syntactic behavior. Then I examine the question of the categorial status of Class 2 prepositions and demonstrate that they are not to be regarded as nouns. Finally I present the extended PP projection of Persian spatial prepositions and argue for a feature-based analysis of the properties they manifest.

  11. Class, Culture and Politics

    DEFF Research Database (Denmark)

    Harrits, Gitte Sommer

    2013-01-01

    Even though contemporary discussions of class have moved forward towards recognizing a multidimensional concept of class, empirical analyses tend to focus on cultural practices in a rather narrow sense, that is, as practices of cultural consumption or practices of education. As a result......, discussions within political sociology have not yet utilized the merits of a multidimensional conception of class. In light of this, the article suggests a comprehensive Bourdieusian framework for class analysis, integrating culture as both a structural phenomenon co-constitutive of class and as symbolic...

  12. A1. Course Prep.

    OpenAIRE

    2014-01-01

    Cualquier entidad que pretenda desarrollar iniciativas de formación en modalidad de eLearning se enfrenta a una serie de decisiones estratégicas que van desde la dotación de una infraestructura tecnológica (tanto software como hardware) hasta el establecimiento de un marco de evaluación o reconocimiento del aprendizaje, pasando por la definición de un modelo de eLearning para la entidad, un catálogo de competencias, etc. En este patrón de arquitectura se definen los elementos críticos que ...

  13. MIA: Accuplacer Prep

    Science.gov (United States)

    Kaplan, Gary

    2014-01-01

    Accuplacer is, like the SAT, a suite of tests. It assesses concrete English and math skills--things like decimals, percents, equations, reading comprehension and basic writing skills. Accuplacer tests are used by community colleges, state colleges and public universities in all New England states to place incoming students in the right courses.…

  14. Formalizing Implementation Strategies for First-Class Continuations

    DEFF Research Database (Denmark)

    Danvy, Olivier

    1999-01-01

    We present the first formalization of implementation strategies for first-class continuations. The formalization hinges on abstract machines for continuation-passing style (CPS) programs with a special treatment for the current continuation, accounting for the essence of first-class continuations....... These abstract machines are proven equivalent to a standard, substitution-based abstract machine. The proof techniques work uniformly for various representations of continuations. As a byproduct, we also present a formal proof of the two folklore theorems that one continuation identifier is enough for second......-class continuations and that second-class continuations are stackable. A large body of work exists on implementing continuations, but it is predominantly empirical and implementation-oriented. In contrast, our formalization abstracts the essence of first-class continuations and provides a uniform setting...

  15. Formalizing Implementation Strategies for First-Class Continuations

    DEFF Research Database (Denmark)

    Danvy, Olivier

    2000-01-01

    We present the first formalization of implementation strategies for first-class continuations. The formalization hinges on abstract machines for continuation-passing style (CPS) programs with a special treatment for the current continuation, accounting for the essence of first-class continuations....... These abstract machines are proven equivalent to a standard, substitution-based abstract machine. The proof techniques work uniformly for various representations of continuations. As a byproduct, we also present a formal proof of the two folklore theorems that one continuation identifier is enough for second......-class continuations and that second-class continuations are stackable. A large body of work exists on implementing continuations, but it is predominantly empirical and implementation-oriented. In contrast, our formalization abstracts the essence of first-class continuations and provides a uniform setting...

  16. Testing automated liquid-based cytology samples with a manual liquid-based cytology method using residual cell suspensions from 500 ThinPrep cases.

    Science.gov (United States)

    Maksem, John A; Dhanwada, Vijaya; Trueblood, Joy E; Weidmann, James; Kane, Bruce; Bolick, David R; Bedrossian, Carlos W M; Kurtycz, Daniel F I; Stewart, Jim

    2006-06-01

    We report a technical improvement upon a previously disclosed manual liquid-based cytology (MLBC) method; and, we use the improved method to prepare slides from residual ThinPrep specimens in order to see how often ThinPrep diagnoses correspond to diagnoses derived from exhaustive examination of their parent sample suspensions. Residual cell suspensions from 500 ThinPrep cases comprising (1) 20 low-grade squamous intraepithelial lesions (LSILs); (2) 200 high risk (HR) negatives and 20 ASC-US; and (3) 260 screening cytology specimens were studied. Institutional review committee guidelines allowed us to know diagnoses by groups of specimens, but did not allow us to know individual patient diagnoses, so we could not perform case-by-case matched outcome-comparisons. Cells were concentrated by conventional centrifugation and sedimented into a polymer gel that was then vortex-mixed and converted into a viscous cell-rich suspension. The cell suspension was smeared between two clean glass slides, which were air-dried and stained with the Papanicolaou stain. Two study-sets were created, comprising one slide from each case. Each of the two study sets was examined by two cytopathologists, and discordant diagnoses were adjudicated. Because of the ambiguity involved in the "atypical" (ASC-US, ASC-H, AGC) diagnosis categories, only outcomes at the level of LSIL or greater were recorded. All MLBC SILs were digitally imaged and abnormal slides plus digital images were sent to the laboratory that provided the residual automated liquid-based cytology (ALBC) suspensions. The final diagnoses were confirmed by the laboratory that provided the residual ALBC specimens. MLBC slides of the 20 LSIL cases afforded 2 high-grade squamous intraepithelial lesions (HSILs) and 18 LSILs. Those of the 200 HR-Negatives showed 3 HSILs and 30 LSILs; and those of the 20 HR-ASC-US showed 3 HSILs and 9 LSILs. MLBC slides of the 260 screening cytology specimens showed 1 Carcinoma, 3 HSILs and 20 LSILs

  17. 爱护佳手消毒液不同消毒方法在术前应用的比较分析%Comparative research about application effects of different hand prepping by avagard before the operation

    Institute of Scientific and Technical Information of China (English)

    刘艳玲; 杨绮莉; 王耀兰; 黎穗

    2010-01-01

    Objective To know the application effects of two different hand prepping by avagard before the operation.Methods Divided operation-actors into the experimental group (121 cases) and the control group (116 cases)randomly.Kneading hand prepping by 9200 and 9230 avagard was used in the experimental group, while the brushing by 9241- D and 9250 was used in the control group.Compared the effects between the two groups.Results There was no significant difference about disinfection effects between the two groups, while the compliance of kneading hand prepping was more better than the other hand prepping method.Condusions Kneading hand prepping by avagard 9200 should be used before surgical operation.%目的 比较3M公司生产的2种爱护佳手消毒液在外科手消毒中的应用效果.方法 将参加手术的医护人员随机分为实验组121例和对照组116例.实验组的手消毒采用揉搓法,手消毒液为9200+9230.对照组的手消毒采用刷手法,消毒液为9241-D+9250.比较2组手消毒效果.结果 2组手消毒效果比较无显著差异,但揉搓法更加人性化,操作者的依从性更高.结论 在外科手消毒时建议使用9200+9230手消毒液揉搓消毒的方法.

  18. Line-item veto may pass this month

    Science.gov (United States)

    U.S. House and Senate Republicans have cleared the way for legislation to give the President the power of a line-item-veto in time for the 1998 budget season.The line-item veto, as proposed, would allow the President to remove from appropriations bills selected appropriations items, new entitlement spending, or narrowly targeted tax breaks. Once a line item is cut from the budget, Congress would have to pass a separate appropriations bill for that individual item; that new, separate bill would then be subject to the traditional Presidential veto.

  19. Forgotten Kirschner wire passing across the sigmoid colon.

    Science.gov (United States)

    Matsumoto, Hiroshi; Yo, Shogen; Fukushima, Shinya; Osawa, Motoyasu; Murao, Takahiro; Ishii, Manabu; Fujita, Minoru; Shiotani, Akiko

    2017-04-01

    The Kirschner wire (K-wire) is used in the treatment of hip fractures, and migration of a K-wire into the pelvis with resultant colon injury is a very rare complication. We report a case in which a forgotten K-wire passing across the sigmoid colon was accidentally found by screening colonoscopy in a patient with no abdominal symptoms. Surgery was performed to remove the K-wire. Although the migration of a K-wire is extremely rare, it is important for it to be considered in patients with a history of orthopedic surgery.

  20. Band-pass filtered velocity statistics in decaying turbulent box

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    For homogeneous isotropic turbulence study,the acquisition of band-pass filtered velocity increments(FVI) in a non-forced turbulent box is still a challenge both experimentally and numerically.Turbulence and associated physical processes,at a given instant,are permanently contaminated by a forcing process which can seldom be universal.The situation tends to be the origin of intermittency and the non-Gaussian probability density distribution for acceleration and velocity gradients.To reveal implied mechanism...

  1. UAVSAR: Airborne L-band Radar for Repeat Pass Interferometry

    Science.gov (United States)

    Moes, Timothy R.

    2009-01-01

    The primary objectives of the UAVSAR Project were to: a) develop a miniaturized polarimetric L-band synthetic aperture radar (SAR) for use on an unmanned aerial vehicle (UAV) or piloted vehicle. b) develop the associated processing algorithms for repeat-pass differential interferometric measurements using a single antenna. c) conduct measurements of geophysical interest, particularly changes of rapidly deforming surfaces such as volcanoes or earthquakes. Two complete systems were developed. Operational Science Missions began on February 18, 2009 ... concurrent development and testing of the radar system continues.

  2. Battle of Kasserine Pass: Defeat is a Matter of Scale

    Science.gov (United States)

    2016-05-26

    America’s First Battles, 247. 7 Ernest Harmon, Combat Commander: Autobiography of a Soldier (New Jersey: Prentice- Hall , 1970), 146. 5 ENGIMA. The...Armored Division on February 14. The 10th Panzer Division quickly destroyed the ten M3 Stuart tanks of the 2nd Battalion, 168th Regimental Combat Team...Kasserine Pass.44 He is correct if he is comparing the diminutive M3 Stuart or the cobbled together M3 Grant/Lee to the German Panzer IV. The M4 Sherman

  3. Time Really Passes, Science Can't Deny That

    CERN Document Server

    Gisin, Nicolas

    2016-01-01

    Today's science provides quite a lean picture of time as a mere geometric evolution parameter. I argue that time is much richer. In particular, I argue that besides the geometric time, there is creative time, when objective chance events happen. The existence of the latter follows straight from the existence of free-will. Following the french philosopher Lequyer, I argue that free-will is a prerequisite for the possibility to have rational argumentations, hence can't be denied. Consequently, science can't deny the existence of creative time and thus that time really passes.

  4. Double passing the Kitt Peak 1-m Fourier transform spectrometer

    Science.gov (United States)

    Jennings, D. E.; Hubbard, R.; Brault, J. W.

    1985-01-01

    Attention is given to a simple technique for performing the conversion of the Kitt Peak 1-m Fourier transform spectrometer's dual input/output optical configuration to a double pass configuration that improves spectral resolution by a factor of 2. The modification is made by placing a flat mirror in the output beam from each cat's eye, retroreflecting the beams back through the cat's eyes to the first beam splitter. A single detector is placed at the second input port, which then becomes the instrument's output.

  5. Single pass Doppler positioning for Search and Rescue satellite missions

    Science.gov (United States)

    Schmid, P. E.; Vonbun, F. O.; Lynn, J. J.

    1976-01-01

    This paper describes the implementation of beacon location experiments involving the NASA Nimbus-6 and the Amateur Satellite Corporation (AMSAT) Oscar-6 and Oscar-7 spacecraft. The purpose of these experiments is to demonstrate the feasibility of determining the geographical location of a low power VHF 'distress beacon' via satellite. Doppler data collected during satellite passes is reduced in a mini-computer by means of a simple algorithm resulting in the simultaneous recovery of the unknown receiver coordinates and the unknown Doppler bias frequency. Results indicate point positioning to within a few kilometers - which is within the required accuracies for the positioning of downed aircraft for Search/Rescue missions.

  6. Vehicle passes detector based on multi-sensor analysis

    Science.gov (United States)

    Bocharov, D.; Sidorchuk, D.; Konovalenko, I.; Koptelov, I.

    2015-02-01

    The study concerned deals with a new approach to the problem of detecting vehicle passes in vision-based automatic vehicle classification system. Essential non-affinity image variations and signals from induction loop are the events that can be considered as detectors of an object presence. We propose several vehicle detection techniques based on image processing and induction loop signal analysis. Also we suggest a combined method based on multi-sensor analysis to improve vehicle detection performance. Experimental results in complex outdoor environments show that the proposed multi-sensor algorithm is effective for vehicles detection.

  7. Low-pass sequencing for microbial comparative genomics

    Directory of Open Access Journals (Sweden)

    Kennedy Sean

    2004-01-01

    Full Text Available Abstract Background We studied four extremely halophilic archaea by low-pass shotgun sequencing: (1 the metabolically versatile Haloarcula marismortui; (2 the non-pigmented Natrialba asiatica; (3 the psychrophile Halorubrum lacusprofundi and (4 the Dead Sea isolate Halobaculum gomorrense. Approximately one thousand single pass genomic sequences per genome were obtained. The data were analyzed by comparative genomic analyses using the completed Halobacterium sp. NRC-1 genome as a reference. Low-pass shotgun sequencing is a simple, inexpensive, and rapid approach that can readily be performed on any cultured microbe. Results As expected, the four archaeal halophiles analyzed exhibit both bacterial and eukaryotic characteristics as well as uniquely archaeal traits. All five halophiles exhibit greater than sixty percent GC content and low isoelectric points (pI for their predicted proteins. Multiple insertion sequence (IS elements, often involved in genome rearrangements, were identified in H. lacusprofundi and H. marismortui. The core biological functions that govern cellular and genetic mechanisms of H. sp. NRC-1 appear to be conserved in these four other halophiles. Multiple TATA box binding protein (TBP and transcription factor IIB (TFB homologs were identified from most of the four shotgunned halophiles. The reconstructed molecular tree of all five halophiles shows a large divergence between these species, but with the closest relationship being between H. sp. NRC-1 and H. lacusprofundi. Conclusion Despite the diverse habitats of these species, all five halophiles share (1 high GC content and (2 low protein isoelectric points, which are characteristics associated with environmental exposure to UV radiation and hypersalinity, respectively. Identification of multiple IS elements in the genome of H. lacusprofundi and H. marismortui suggest that genome structure and dynamic genome reorganization might be similar to that previously observed in the

  8. Fault-tolerant Agreement in Synchronous Message-passing Systems

    CERN Document Server

    Raynal, Michel

    2010-01-01

    The present book focuses on the way to cope with the uncertainty created by process failures (crash, omission failures and Byzantine behavior) in synchronous message-passing systems (i.e., systems whose progress is governed by the passage of time). To that end, the book considers fundamental problems that distributed synchronous processes have to solve. These fundamental problems concern agreement among processes (if processes are unable to agree in one way or another in presence of failures, no non-trivial problem can be solved). They are consensus, interactive consistency, k-set agreement an

  9. Class network routing

    Science.gov (United States)

    Bhanot, Gyan; Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Takken, Todd E.; Vranas, Pavlos M.

    2009-09-08

    Class network routing is implemented in a network such as a computer network comprising a plurality of parallel compute processors at nodes thereof. Class network routing allows a compute processor to broadcast a message to a range (one or more) of other compute processors in the computer network, such as processors in a column or a row. Normally this type of operation requires a separate message to be sent to each processor. With class network routing pursuant to the invention, a single message is sufficient, which generally reduces the total number of messages in the network as well as the latency to do a broadcast. Class network routing is also applied to dense matrix inversion algorithms on distributed memory parallel supercomputers with hardware class function (multicast) capability. This is achieved by exploiting the fact that the communication patterns of dense matrix inversion can be served by hardware class functions, which results in faster execution times.

  10. Culture and social class.

    Science.gov (United States)

    Miyamoto, Yuri

    2017-08-08

    A large body of research in Western cultures has demonstrated the psychological and health effects of social class. This review outlines a cultural psychological approach to social stratification by comparing psychological and health manifestations of social class across Western and East Asian cultures. These comparisons suggest that cultural meaning systems shape how people make meaning and respond to material/structural conditions associated with social class, thereby leading to culturally divergent manifestations of social class. Specifically, unlike their counterparts in Western cultures, individuals of high social class in East Asian cultures tend to show high conformity and other-orientated psychological attributes. In addition, cultures differ in how social class impacts health (i.e. on which bases, through which pathways, and to what extent). Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. How Bioethics is Complementing Human Rights in Realizing Health Access for Clinical Trial Participants: The Case of Formative PrEP Access in South Africa.

    Science.gov (United States)

    Singh, Jerome

    2015-06-11

    Following the demise of apartheid, human rights in South Africa are now constitutionally enshrined.The right to health in South Africa's Constitution has been credited with transforming the lives of millions of people by triggering programmatic reforms in HIV treatment and the prevention of mother to child transmission (MTCT) of HIV.However, a constitutionally enshrined right to health offers no guarantee that clinical trial participants will enjoy post-trial access to beneficial interventions. Using access to HIV pre-exposure prophylaxis (PrEP) in South Africa as an example, this paper argues that adherence to bioethics norms could realize the right to health for trial participants following the end of a clinical trial.

  12. Comparison of two different deposition methods of 3-aminopropyltriethoxysilane on glass slides and their application in the ThinPrep cytologic test.

    Science.gov (United States)

    Xiang, Sen; Xing, Gaowa; Xue, Wei; Lu, Chao; Lin, Jin-Ming

    2012-04-07

    In this work, two different deposition methods of 3-aminopropyltriethoxysilane (APTES) on glass slides were compared in order to study the adhesion effect of cervical exfoliated cells on smear slides. Glass slides were modified by vapor-phase deposition (V-D) and liquid-phase deposition (L-D), respectively. The topographic images and amine density of the modified slides were investigated by using atomic force microscopy, UV-vis spectroscopy and X-ray photoelectron spectroscopy. The numbers of cells adhered on the slides functionalized by V-D and L-D were counted and compared under the microscope. The data showed significant differences between the two methods (t-test: P < 0.05). The results presented here have made it theoretically possible to produce amine slides by V-D method for the ThinPrep cytologic test.

  13. PREP-CHEM-SRC – 1.0: a preprocessor of trace gas and aerosol emission fields for regional and global atmospheric chemistry models

    Directory of Open Access Journals (Sweden)

    S. R. Freitas

    2011-05-01

    Full Text Available The preprocessor PREP-CHEM-SRC presented in the paper is a comprehensive tool aiming at preparing emission fields of trace gases and aerosols for use in atmospheric-chemistry transport models. The considered emissions are from the most recent databases of urban/industrial, biogenic, biomass burning, volcanic, biofuel use and burning from agricultural waste sources. For biomass burning, emissions can be also estimated directly from satellite fire detections using a fire emission model included in the tool. The preprocessor provides emission fields interpolated onto the transport model grid. Several map projections can be chosen. The inclusion of these emissions in transport models is also presented. The preprocessor is coded using Fortran90 and C and is driven by a namelist allowing the user to choose the type of emissions and the databases.

  14. The exploitation of "Exploitation" in the tenofovir prep trial in Cameroon: Lessons learned from media coverage of an HIV prevention trial.

    Science.gov (United States)

    Mack, Natasha; Robinson, Elizabeth T; MacQueen, Kathleen M; Moffett, Jill; Johnson, Laura M

    2010-06-01

    media coverage influences how clinical trials are perceived internationally and in communities where trials occur, affecting recruitment, retention, and political support for research. We conducted a discourse analysis of news coverage from 2004-2005 of a trial in Cameroon on oral PrEP for HIV prevention, to identify messages, communication techniques, and sources of messages that were amplified via media. We identified two parallel discourses: one on ethical concerns about the Cameroon trial, and a second, more general "science exploitation" discourse concerned with the potential for trials with vulnerable participant populations to be conducted unethically, benefiting only wealthy populations. Researchers should overtly address exploitation as an integral, ongoing component of research, particularly where historical or cultural conditions set the stage for controversy to emerge.

  15. Fostering a Middle Class

    Institute of Scientific and Technical Information of China (English)

    YAO BIN

    2011-01-01

    Though there is no official definition of "middle class" in China,the tag has become one few Chinese people believe they deserve anyway.In early August,the Chinese Academy of Social Sciences released a report on China's urban development,saying China had a middle-class population of 230 million in 2009,or 37 percent of its urban residents.It also forecast half of city dwellers in China would be part of the middle class by 2023.

  16. Ring formation by tidal disruption of a passing body

    Science.gov (United States)

    Hyodo, Ryuki; Charnoz, Sébastien; Genda, Hidenori; Ohtsuki, Keiji

    2016-10-01

    The origin of rings around giant planets remains elusive. Here we investigate the tidal disruption of a passing object and the subsequent formation of planetary rings. First, we perform SPH simulations of the tidal destruction of differentiated objects with the mass of M~1022kg that experience close encounters with Saturn or Uranus. We find that about 0.1-10% of the mass of the passing body is gravitationally captured around the planet. However, these fragments are initially big chunks and have highly eccentric orbits around the planet. Therefore, in order to see their long-term evolution, we perform N-body simulations including the planet's oblateness up to J4 starting with data obtained from the SPH simulations. Our N-body simulations show that the chunks are tidally destructed during their next several orbits and become collections of smaller particles. Their individual orbits then start to precess incoherently around the planet's equator, which enhances their encounter velocities on longer-term evolution, resulting in more destructive impacts. These collisions would damp their eccentricities resulting in a progressive collapse of the debris cloud into a thin equatorial and low-eccentricity ring.

  17. Quantitative modelling in cognitive ergonomics: predicting signals passed at danger.

    Science.gov (United States)

    Moray, Neville; Groeger, John; Stanton, Neville

    2017-02-01

    This paper shows how to combine field observations, experimental data and mathematical modelling to produce quantitative explanations and predictions of complex events in human-machine interaction. As an example, we consider a major railway accident. In 1999, a commuter train passed a red signal near Ladbroke Grove, UK, into the path of an express. We use the Public Inquiry Report, 'black box' data, and accident and engineering reports to construct a case history of the accident. We show how to combine field data with mathematical modelling to estimate the probability that the driver observed and identified the state of the signals, and checked their status. Our methodology can explain the SPAD ('Signal Passed At Danger'), generate recommendations about signal design and placement and provide quantitative guidance for the design of safer railway systems' speed limits and the location of signals. Practitioner Summary: Detailed ergonomic analysis of railway signals and rail infrastructure reveals problems of signal identification at this location. A record of driver eye movements measures attention, from which a quantitative model for out signal placement and permitted speeds can be derived. The paper is an example of how to combine field data, basic research and mathematical modelling to solve ergonomic design problems.

  18. Passing messages between biological networks to refine predicted interactions.

    Directory of Open Access Journals (Sweden)

    Kimberly Glass

    Full Text Available Regulatory network reconstruction is a fundamental problem in computational biology. There are significant limitations to such reconstruction using individual datasets, and increasingly people attempt to construct networks using multiple, independent datasets obtained from complementary sources, but methods for this integration are lacking. We developed PANDA (Passing Attributes between Networks for Data Assimilation, a message-passing model using multiple sources of information to predict regulatory relationships, and used it to integrate protein-protein interaction, gene expression, and sequence motif data to reconstruct genome-wide, condition-specific regulatory networks in yeast as a model. The resulting networks were not only more accurate than those produced using individual data sets and other existing methods, but they also captured information regarding specific biological mechanisms and pathways that were missed using other methodologies. PANDA is scalable to higher eukaryotes, applicable to specific tissue or cell type data and conceptually generalizable to include a variety of regulatory, interaction, expression, and other genome-scale data. An implementation of the PANDA algorithm is available at www.sourceforge.net/projects/panda-net.

  19. Passing messages between biological networks to refine predicted interactions.

    Science.gov (United States)

    Glass, Kimberly; Huttenhower, Curtis; Quackenbush, John; Yuan, Guo-Cheng

    2013-01-01

    Regulatory network reconstruction is a fundamental problem in computational biology. There are significant limitations to such reconstruction using individual datasets, and increasingly people attempt to construct networks using multiple, independent datasets obtained from complementary sources, but methods for this integration are lacking. We developed PANDA (Passing Attributes between Networks for Data Assimilation), a message-passing model using multiple sources of information to predict regulatory relationships, and used it to integrate protein-protein interaction, gene expression, and sequence motif data to reconstruct genome-wide, condition-specific regulatory networks in yeast as a model. The resulting networks were not only more accurate than those produced using individual data sets and other existing methods, but they also captured information regarding specific biological mechanisms and pathways that were missed using other methodologies. PANDA is scalable to higher eukaryotes, applicable to specific tissue or cell type data and conceptually generalizable to include a variety of regulatory, interaction, expression, and other genome-scale data. An implementation of the PANDA algorithm is available at www.sourceforge.net/projects/panda-net.

  20. A cryogenic circulating advective multi-pass absorption cell

    Science.gov (United States)

    Stockett, M. H.; Lawler, J. E.

    2012-03-01

    A novel absorption cell has been developed to enable a spectroscopic survey of a broad range of polycyclic aromatic hydrocarbons (PAH) under astrophysically relevant conditions and utilizing a synchrotron radiation continuum to test the still controversial hypothesis that these molecules or their ions could be carriers of the diffuse interstellar bands. The cryogenic circulating advective multi-pass absorption cell resembles a wind tunnel; molecules evaporated from a crucible or injected using a custom gas feedthrough are entrained in a laminar flow of cryogenically cooled buffer gas and advected into the path of the synchrotron beam. This system includes a multi-pass optical White cell enabling absorption path lengths of hundreds of meters and a detection sensitivity to molecular densities on the order of 107 cm-3. A capacitively coupled radio frequency dielectric barrier discharge provides ionized and metastable buffer gas atoms for ionizing the candidate molecules via charge exchange and the Penning effect. Stronger than expected clustering of PAH molecules has slowed efforts to record gas phase PAH spectra at cryogenic temperatures, though such clusters may play a role in other interstellar phenomena.