WorldWideScience

Sample records for prep bridge program

  1. PREP program annual report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    A total of thirty-three 9th and 10th grade American Indian students participated in the program. Curricular focal points were environmental science, supported by courses and labs in mathematics, technical writing, and chemistry. The 1994 summer program was the second year of the environmental science focus. The environmental component covered four topics during the month-long program: drinking water, waste water, solid waste pollution, and mining reclamation. The overall goal of the project was to encourage a greater number of the targeted high school students to acquire the necessary skills to succeed in rigorous college academic programs and to enter science-based disciplines. Students participating in the program were involved in a rigorous daily academic program of formal instruction. Participants lived in the residence halls and participated in many aspects of college life, including planned recreational activities. Students were also involved in academic year activities to maintain a heightened awareness and interest in science-based fields. These goals were met and the program was judged to be a success.

  2. SKILL PREP Program for American Indian Students. Final report, 1994

    Energy Technology Data Exchange (ETDEWEB)

    McCulloh, S.; Huebner, P.

    1995-10-01

    The Scientific Knowledge for Indian Learning and Leadership (SKILL) precollege college program of the South Dakota School of Mines and Technology concluded the 1994 PREP program on July 22, 1994. The program graduated 22 students from the 4-week residential math/science program for American Indian students. Primary academic focus was physics (30 hours); each student was given a bicycle to solve problems on angular momentum and mechanical advantage. Mathematical calculations and problem solving exercises were done in mathematics class (20 hours). Preliminary results in math, physics, and geology show dramatic increases in student achievement over the 4- week period. The program paired every two students with a faculty member or research scientist, and each team completed a research project.

  3. Planning a Tech Prep Program in Hospitality. Final Report.

    Science.gov (United States)

    Chicago City Colleges, IL. Chicago City-Wide Coll.

    A project conducted to establish tech prep articulation training agreements between City Colleges of Chicago and several public secondary schools is described in this report. Project activities were as follows: (1) developed a handbook to define the tech prep experience and guide committee members on how tech prep can be a valuable asset to…

  4. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  5. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  6. How To Implement a Tech Prep Program Based on the Rhode Island Model. Tech Prep Associate Degree Program. Technical Programs. Business/Office Administration Programs. Allied Health/Dental Health Programs.

    Science.gov (United States)

    Community Coll. of Rhode Island, Warwick.

    This implementation guide contains information based on experiences that occurred during the development and implementation of the Rhode Island Tech Prep Model. It is intended to assist educators in addressing challenges and obstacles faced by the program early in the planning process. It begins with a rationale for tech prep. Rhode Island…

  7. The Bridges Program.

    Science.gov (United States)

    Bohnen, Elizabeth; Klie, Judy

    This report describes BRIDGES, an employment equity special measures training program developed by the City of Toronto (Ontario, Canada). It was designed to help women employees move from their traditional jobs into trades, technical or operation (TTO) jobs within their own organization. The program is a combination of classroom sessions, shop…

  8. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  9. Including an Exam P/1 Prep Course in a Growing Actuarial Science Program

    Science.gov (United States)

    Wakefield, Thomas P.

    2014-01-01

    The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…

  10. Final report for the Pre-Freshman Enrichment Program (PREP)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This project reflected cooperation across the disciplines in the physical sciences, engineering, mathematics and computer science. The University of the Pacific served as the center for this pre-college program. The idea was to use this link as a pilot program.

  11. Houston Pre-Freshman Enrichment Program (Houston PREP). Final report, June 9, 1997--July 25, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The 1997 Houston Pre-Freshman Enrichment Program (PREP) was conducted at the campus of the University of Houston-Downtown from June 9 to July 25, 1997. Program participants were recruited from the Greater Houston Area. All participants were identified as high-achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Clear Creek, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 194 students starting the program, 165 students were from economically and socially disadvantage groups under-represented in the engineering and science professions, and 118 of the 194 were women. Our First Year group for 1997 composed of 96% minority and women students. Second and Third Year students combined were 96% minority or women. With financial support from the Center for Computational Sciences and Advanced Distributed Simulation, the Fourth Year Program was added to PREP this year. Twelve students completed the program (83% minority or women).

  12. An Exploratory Investigation of the Promoting Responsibility through Education and Prevention (PREP) after School Program for African American At-Risk Elementary School Students

    Science.gov (United States)

    Sale, Elizabeth; Weil, Virginia; Kryah, Rachel

    2012-01-01

    The promoting responsibility through education and prevention (PREP) program is an after school substance abuse and violence prevention program for at-risk fourth and fifth grade youths in St. Louis, Missouri. Staffed by licensed clinical social workers and professional volunteers, PREP offers cultural cooking classes, yoga, and art as well as…

  13. Houston prefreshman enrichment program (Houston PREP). Final report, June 10, 1996--August 1, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The 1996 Houston Pre-freshman Enrichment Program (PREP) was conducted on the campus of the University of Houston-Downtown from June 10 to August 1, 1996. Program Participants were recruited from the Greater Houston area. All participants were identified as high achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Crockett, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 197 students starting the program, 170 completed, 142 students were from economically and socially disadvantage groups underrepresented in the engineering and science professions, and 121 of the 197 were female. Our First Year group for 1996 composed of 96% minority and women students. Our Second and Third Year students were 100% and 93.75% minority or women respectively. This gave an overall minority and female population of 93.75%. This year, special efforts were again made to recruit students from minority groups, which caused a significant increase in qualified applicants. However, due to space limitations, 140 applicants were rejected. Investigative and discovery learning were key elements of PREP. The academic components of the program included Algebraic Structures, Engineering, Introduction to Computer Science, Introduction to Physics, Logic and Its Application to Mathematics, Probability and Statistics, Problem Solving Seminar using computers and PLATO software, SAT Preparatory Seminars, and Technical Writing.

  14. Guide for the preparation of proposals for the Pre-Freshman Engineering Program: PREP-1981, (for minorities and women)

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The Pre-Freshman Engineering Program (PREP) for minorities and women (formerly PREFACE) will provide funds to colleges and universities for projects aimed at seeking out minority group individuals and women during junior high school and high school years (7th grade through the summer preceding matriculation in college) and providing them with enrichment experiences. Preparation and submission of proposals, evaluation and selection of proposals for support, and preparation of the final report are described.

  15. 49 CFR 237.33 - Content of bridge management programs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Content of bridge management programs. 237.33... Content of bridge management programs. Each bridge management program adopted in compliance with this part... spans, span lengths, and all other information necessary to provide for the management of bridge...

  16. Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.

    Science.gov (United States)

    Clayton, Amy C; Bentz, Joel S; Wasserman, Patricia G; Schwartz, Mary R; Souers, Rhona J; Chmara, Beth Anne; Laucirica, Rodolfo; Clary, Karen M; Moriarty, Ann T

    2010-08-01

    Differences in participant responses for ThinPrep (TP) and non-ThinPrep (NTP) preparations for gastrointestinal cytology challenges, which circulated in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology (CAP NGC), may help to identify performance variations between preparation types. To compare the performance of TP-prepared slides of gastrointestinal exfoliative cytology specimens to that of NTP preparations in the CAP NGC program. Participant responses between 2000 and 2007 were evaluated for esophageal wash/brush, gastric wash/brush, and biliary tract brush specimens with a reference diagnosis of adenocarcinoma, squamous cell carcinoma, carcinoid, or spindle cell neoplasm. ThinPrep challenges were compared with NTP preparations (conventional smears, cytospins) for discordant responses. In all, 6023 pathologist responses and 3825 cytotechnologist responses were reviewed. Non-ThinPrep preparations comprised 93% (n = 11 588) of the challenges, while 7% (n = 912) were TP material. A match for a "positive/suspicious" diagnosis was seen in 88.5% of NTP and 95.9% of TP preparations (P cytology specimens circulated in an interlaboratory comparison program. Performance varied by reference interpretation, with the best performance for the interpretation of adenocarcinoma. Cytotechnologists and pathologists performed at the same level overall, but with differences for the diagnosis of spindle cell neoplasm and squamous carcinoma.

  17. Guide for the preparation of proposals for the Pre-Freshman Engineering Program: PREP - 1984 (for minorities and women)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1983-08-01

    The Pre-Freshman Engineering Program (PREP) for minorities and women (formerly PREFACE) will provide funds to colleges and universities for projects aimed at seeking out minority group individuals and women during junior high school and high school years (7th grade through 12th grade) and providing them with enrichment experiences. These experiences shall consist of activities to identify, motivate and prepare students for engineering studies. Emphasis is on the individuals identified, regardless of where they may decide to matriculate for undergraduate studies. Work experience is believed to contribute to the success of these projects because it exposes students to the real world of work of the professional engineer. However, no DOE funds may be used directly to support such work experiences. Eligible organizations, limitations of funding, preparation and submission of proposals, evaluation and selection of proposals, and the final report are discussed.

  18. Do College-Prep Programs Improve Long-Term Outcomes? NBER Working Paper No. 17859

    Science.gov (United States)

    Jackson, C. Kirabo

    2012-01-01

    I analyze the longer-run effects of a college-preparatory program implemented in inner-city schools that included payments to eleventh- and twelfth- grade students and their teachers for passing scores on Advanced Placement exams. Affected students attended college in greater numbers, were more likely to remain in college beyond their first year,…

  19. PREP Program: High school urban engineering technical progress report, Summer 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The Urban Engineering Program at the New Jersey Institute of Technology which as its primary objective is to introduce the students to the excitement of science and engineering as potential career opportunities, and to encourage the youngsters to adequately prepare in high school and in college for such an attainable endeavor. Through the course work, workshops, projects, guest speakers, and laboratory experiences, the students are not only introduced to the problems in urban areas, but also are introduced to the tools and analysis available to solve such problems.

  20. Building Better Bridges: An Evaluation of The Bridge to the Ph.D. Program

    Science.gov (United States)

    Ellyn Sanderson, Robyn; Lobel, Caroline; Agueros, Marcel A.; Anderson, Vanessa; Ash, Summer; Purdie-Vaughns, Valerie; Romero-Canyas, Rainer; Walker, Erica

    2016-01-01

    Columbia University's Bridge to the Ph.D. in the Natural Sciences Program is increasing the number of underrepresented scholars entering graduate programs and equipping them to succeed in these programs. In a given year, three to five Bridge participants are hired as full-time Columbia University research assistants for up to two years. Now in its seventh year, the Program supports seven participants, and its alumni (including five astronomers) have gone on to Ph.D. programs across the country. Although to date fewer than 40 people have participated in the Program, a number too small for an exclusively statistical evaluation of its effectiveness, we are collecting invaluable longitudinal data on the career progressions of underrepresented aspiring scientists across the natural sciences. At least a dozen Bridge alumni will earn their Ph.D. in the next two-three years, and we will then learn much more about the impact that the Bridge Program has had on our participants' trajectories. Among other things, we hope to use these data to determine the Program's effectiveness in developing feelings of self-efficacy and participants' confidence in their ability to succeed in doctoral programs, to measure the rate at which Bridge alumni successfully complete doctoral programs relative to their peers, and to identify the aspects of the Program that participants find most helpful to their progress at different stages of their paths to and through doctoral programs. Here we describe the data we have already obtained as part of our on-going study, and preliminary results from our analysis.

  1. The Bridge and the Troll Underneath: Summer Bridge Programs and Degree Completion

    Science.gov (United States)

    Douglas, Daniel; Attewell, Paul

    2014-01-01

    College graduation rates in the United States are low in both real and relative terms. This has left all stakeholders looking for novel solutions while perhaps ignoring extant but underused programs. This article examines the effect of "summer bridge" programs, which have students enroll in coursework prior to beginning their first full…

  2. New Program Builds Bridges for Hearing Impaired.

    Science.gov (United States)

    Johnson, Jeannie

    1998-01-01

    Describes a new approach to teaching English-as-a-Second-Language to New Mexico elementary school students who have hearing impairments and whose dominant language is American Sign Language (ASL). These students must first acquire ASL as a bridge to learning English. Then, using the bilingual approach, they are able to focus on English literacy.…

  3. New Program Builds Bridges for Hearing Impaired.

    Science.gov (United States)

    Johnson, Jeannie

    1998-01-01

    Describes a new approach to teaching English-as-a-Second-Language to New Mexico elementary school students who have hearing impairments and whose dominant language is American Sign Language (ASL). These students must first acquire ASL as a bridge to learning English. Then, using the bilingual approach, they are able to focus on English literacy.…

  4. Bridge to Success: Insight into Summer Bridge Program Students' College Transition

    Science.gov (United States)

    Walpole, MaryBeth; Simmerman, Herb; Mack, Cathy; Mills, John T.; Scales, Michael; Albano, Donna

    2008-01-01

    This study examines the college transition of students who participated in a summer bridge program. Three surveys collected longitudinal data on these students' aspirations and academic and social activities. Data provided from institutional research on their academic progress were also analyzed. A control group composed of non-participating…

  5. NASDS- NASTRAN/DISCOS/SAMSAN DMAP BRIDGING PROGRAM

    Science.gov (United States)

    Frisch, H. P.

    1994-01-01

    The design of a controller for a flexible structure requires an ability to obtain flexible body data in a format compatible with design and performance evaluation methods. The control designer may have to work with several different programs to obtain all the data and capabilities he needs. The NASTRAN/DISCOS/SAMSAN bridging program and its associated data file processor provide the flexible structure control designer with a means of tying together the following programs: 1) the NASA Structural Analysis (NASTRAN) system which provides general finite element and matrix manipulation capabilities for the analysis of structures, 2) the Dynamic Interaction Simulation of Controls and Structure (DISCOS) program which provides for the time and frequency domain analysis of any dynamic system that can be modeled as a system of interconnected rigid and flexible bodies, and 3) the SAMSAN library which provides a self-consistent set of algorithms for the support of large-order controls system design and evaluation studies with an emphasis on sampled system analysis. The NASTRAN/DISCOS/SAMSAN bridging program allows the engineer to integrate these three programs into a complete package for the design and analysis of flexible structure controllers. The NASTRAN/DISCOS/SAMSAN bridging program and its associated data file processor may be used to obtain all of the data necessary for defining a flexible body to DISCOS or to any program developed using the SAMSAN library. The bridging program consists of a NASTRAN DMAP sequence which may be used to obtain a variety of different types of modal data including standard, Craig-Bampton, augmented body, and boundary compliance. The user may also request the generation of the following: mass, stiffness, damping, and constraint matrices; data for fine to coarse mesh mass distribution interpolation programs; modal damping, modal observability/ controllability matrices; coarse or fine mesh modal data; and an assortment of matrices useful for

  6. Review of HIV Pre exposure prophylaxis (PrEP) and example of HIV PrEP Toolkit

    Science.gov (United States)

    2017-08-28

    Interventions Aim: to reduce the efficiency of transmission or to shorten the duration of infectiousness Usexual Partners U Sharing Needles Older Age...Program HIV PrEP Portfolio - DoD-wide PrEP experience to date (Beckett, Okulicz, Blaylock/Garges, MHRP/WRAIR*) • Analysis of all DoD beneficiaries

  7. Venture Creation Programs: Bridging Entrepreneurship Education and Technology Transfer

    Science.gov (United States)

    Lackéus, Martin; Williams Middleton, Karen

    2015-01-01

    Purpose: The purpose of this paper is to explore how university-based entrepreneurship programs, incorporating real-life venture creation into educational design and delivery, can bridge the gap between entrepreneurship education and technology transfer within the university environment. Design/methodology/approach: Based on a literature review…

  8. Venture Creation Programs: Bridging Entrepreneurship Education and Technology Transfer

    Science.gov (United States)

    Lackéus, Martin; Williams Middleton, Karen

    2015-01-01

    Purpose: The purpose of this paper is to explore how university-based entrepreneurship programs, incorporating real-life venture creation into educational design and delivery, can bridge the gap between entrepreneurship education and technology transfer within the university environment. Design/methodology/approach: Based on a literature review…

  9. ACT Verbal Prep Course

    CERN Document Server

    Standridge, Nathan

    2012-01-01

    Comprehensive Prep for ACT Verbal. Every year, students pay 1,000 and more to test prep companies to prepare for the verbal sections of the ACT. Now you can get the same preparation in a book. The verbal sections are not easy. There is no quick fix that will allow you to "beat" the ACT, but it is very learnable. If you study hard and master the techniques in this book, your score will improve-significantly. The ACT cannot be "beaten." But it can be mastered-through hard work, analytical thought, and by training yourself to think like a test writer. Many of the exercises in this book are design

  10. SAT math prep course

    CERN Document Server

    Kolby, Jeff

    2011-01-01

    Comprehensive Prep for SAT Math Every year, students pay 1,000 and more to test prep companies to prepare for the math section of the new SAT. Now you can get the same preparation in a book. Features: * Comprehensive Review: Twenty-three chapters provide complete review of SAT math. * Practice: Includes 164 examples and more than 500 exercises! Arranged from easy to medium to hard to very hard. * Diagnostic Test: The diagnostic test measures your strengths and weaknesses and directs you to areas you need to study more. * Performance: If your target is a 700+ score, this is the book!

  11. 77 FR 54652 - Draft Program Comment for Common Post-1945 Concrete and Steel Bridges

    Science.gov (United States)

    2012-09-05

    ... Bridges AGENCIES: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent to issue Program Comment for Common Post-1945 Concrete and Steel Bridges; request for comments. SUMMARY: The Advisory... and steel bridges. The FHWA is requesting comments on the proposed Program Comment. DATES:...

  12. Bridging the Numeracy Gap for Students in Low SES Communities: The Power of a Whole School Approach

    Science.gov (United States)

    Gervasoni, Ann; Parish, Linda; Upton, Cait; Hadden, Teresa; Turkenburg, Kathie; Bevan, Kate; Livesey, Carole; Thompson, Deirdre; Croswell, Melissa; Southwell, Julie

    2010-01-01

    This paper explores the impact of the "Bridging the Numeracy Gap Project" on the whole-number learning of Prep and Grade 1 students living in a low Socio-Economic Status (SES) community. The findings suggest that an approach that includes a specialist mathematics teacher who provides specialised programs for mathematically vulnerable…

  13. The Puzzle of the Tacoma Narrows Bridge Collapse: An Interactive Videodisc Program for Physics Instruction.

    Science.gov (United States)

    Zollman, Dean; Fuller, Robert

    1982-01-01

    An interactive, instructional videodisc was produced using films on wave motion/vibrations and Tacoma Narrows bridge collapse. The disc is appropriate for three levels of physics (physics/algebra; physics/calculus; non-major physics). Program sections (introduction to videodisc player, bridge collapse, influence of wind, bridge properties, and…

  14. PMP exam prep

    CERN Document Server

    Mulcahy, Rita

    2013-01-01

    This book has been FULLY updated to reflect PMI's changes to the PMP exam, and should be used to prepare for all PMP exams delivered on or after July 30th of 2013. Can you imagine valuing a book so much that you send the author a Thank You letter? Hundreds of thousands of project managers know and understand why PMP Exam Prep is a worldwide best-seller. Years of PMP exam preparation experience, endless hours of ongoing research, interviews with project managers who failed the exam to identify gaps in their knowledge, and a razor-sharp focus on making sure project managers don't waste a single minute of their time studying are THE reasons this book is the best-selling PMP exam preparation guide in the world. PMP Exam Prep, Eighth Edition contains hundreds of updates and improvements from previous editions--including new exercises and sample questions never before in print. Offering hundreds of sample questions, critical time-saving tips plus games and activities available nowhere else, this book will help y...

  15. 40 CFR 745.228 - Accreditation of training programs: public and commercial buildings, bridges and superstructures...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Accreditation of training programs: public and commercial buildings, bridges and superstructures. 745.228 Section 745.228 Protection of... of training programs: public and commercial buildings, bridges and superstructures....

  16. I Knew I Would Be Safer. Experiences of Kenyan HIV Serodiscordant Couples Soon After Pre-Exposure Prophylaxis (PrEP) Initiation.

    Science.gov (United States)

    Ngure, Kenneth; Heffron, Renee; Curran, Kathyrn; Vusha, Sophie; Ngutu, Mariah; Mugo, Nelly; Celum, Connie; Baeten, Jared M

    2016-02-01

    Pre-exposure prophylaxis (PrEP) for HIV-uninfected persons is highly efficacious for HIV prevention. Understanding how people at risk for HIV will use PrEP is important to inform PrEP scale-up and implementation. We used qualitative methods to gather insights into couples' early experiences with PrEP use within the Partners Demonstration Project, an open-label implementation study evaluating integrated delivery of PrEP and antiretroviral therapy (ART). PrEP is offered to HIV uninfected partners until the HIV-infected partner initiates and sustains ART use (i.e., PrEP as a "bridge" to ART initiation and viral suppression). From August 2013 to March 2014 we conducted 20 in-depth dyadic interviews (n = 40) with heterosexual HIV serodiscordant couples participating at the Thika, Kenya study site, exploring how couples make decisions about using PrEP for HIV prevention. We developed and applied deductive and inductive codes to identify key themes related to experiences of PrEP initiation and use of time-limited PrEP. Couples reported that PrEP offered them an additional strategy to reduce the risk of HIV transmission, meet their fertility desires, and cope with HIV serodiscordance. Remaining HIV negative at follow-up visits reinforced couples' decisions and motivated continued adherence to PrEP. In addition, confidence in their provider's advice and client-friendly services were critical to their decisions to initiate and continue use of PrEP. Strategies for wide-scale PrEP delivery for HIV serodiscordant couples in low resource settings may include building capacity of health providers to counsel on PrEP adoption while addressing couples' concerns and barriers to adoption and continued use.

  17. Tech Prep and the Rural Context.

    Science.gov (United States)

    Roth, Gene L.

    1996-01-01

    Discusses implementation of tech prep in rural areas and notes that relatively little research has been done on behalf of small town schools. Teachers' comments regarding tech prep implementation provide additional insight into the situation. (JOW)

  18. Mentoring clinical ladder advancement with a facilitated prep class.

    Science.gov (United States)

    Winslow, Susan A; Blankenship, Jean

    2007-01-01

    The authors describe a strategy for encouraging participation and overcoming reluctance of staff to participate in an optional professional advancement career ladder program. A facilitated prep class in a computer skills laboratory provides nurses with the framework for completing application requirements in a casual, supportive atmosphere.

  19. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users.

    Science.gov (United States)

    Shrestha, Roman; Karki, Pramila; Altice, Frederick L; Dubov, Oleksandr; Fraenkel, Liana; Huedo-Medina, Tania; Copenhaver, Michael

    2017-07-10

    Although people who use drugs (PWUD) are one of the key risk populations who could benefit from the use of pre-exposure prophylaxis (PrEP), to date, little attention has been given to incorporating PrEP into HIV prevention approaches targeting this underserved group. This study investigated the acceptability of PrEP based on a number of known PrEP attributes among high-risk PWUD in a drug treatment setting. A total of 400 HIV-negative PWUD, who reported drug- and/or sex-related risk behaviors were recruited from a methadone clinic to complete a stated preference (full-profile conjoint) survey. Participants ranked the eight hypothetical PrEP program scenarios with varied combinations of six attributes related to PrEP (cost, dosing, efficacy, side-effects, treatment setting, and frequency of HIV testing). SPSS conjoint procedure was used to estimate the relative importance of each attribute and preferences across eight possible PrEP delivery programs. PrEP acceptability ranged from 30.6 to 86.3% with a mean acceptability of 56.2% across the eight hypothetical PrEP program scenarios. The PrEP program scenario with the highest acceptability had the following attribute levels: insurance covered, daily dosing, 95% effective, no side-effects, treatment at HIV clinic, and HIV testing needed every 6 months. The cost associated with PrEP was the most important attribute (relative importance score: RIS = 38.8), followed by efficacy (RIS = 20.5) and side effects (RIS = 11.9); other attributes had no significant effect. Our findings reported a high acceptability of PrEP in response to different PrEP program scenarios with different attribute profiles. As the result of having this information, researchers and policymakers will be better equipped for evidence informed targeting and dissemination efforts to optimize PrEP uptake among this underserved population.

  20. Community garden: A bridging program between formal and informal learning

    OpenAIRE

    Ranjan Datta

    2016-01-01

    Community garden activities can play a significant role in bridging formal and informal learning, particularly in urban children’s science and environmental education. It promotes relational methods of learning, discussing, and practicing that will integrate food security, social interactions, community development, environmental activism, and cultural integration. Throughout the last five years of my community garden activities, I have learned that community garden-based practices adhere to ...

  1. Impact of Online Summer Mathematics Bridge Program on Placement Scores and Pass Rates

    Science.gov (United States)

    Frost, Jodi L.; Dreher, J. P.

    2017-01-01

    An online four-week summer mathematics bridge program was implemented at a Midwest university with historically low pass rates in College Algebra and Remedial Mathematics. Students who completed the four week program significantly increased their mathematics placement exam scores. These students also had a higher pass rate in their initial college…

  2. Expanding Pathways: A Summer Bridge Program for Community College STEM Students

    Science.gov (United States)

    Lenaburg, Lubella; Aguirre, Ofelia; Goodchild, Fiona; Kuhn, Jens-Uwe

    2012-01-01

    This paper addresses the transition of community college students to degree programs in science, technology, engineering, and mathematics (STEM). The paper presents the results of an evaluation of a two-week residential summer bridge program that recruited community college students from a wide range of academic, ethnic, and socioeconomic…

  3. Bridging the Divide: Developing a Scholarly Habitus for Aspiring Graduate Students through Summer Bridge Programs Participation

    Science.gov (United States)

    McCoy, Dorian L.; Winkle-Wagner, Rachelle

    2015-01-01

    This multisite case study explored the role of summer institutes in preparing Students of Color for doctoral programs. Bourdieu's social reproduction theory, particularly the concept of habitus, was employed as a theoretical framework to investigate how the participants further developed habitus (their dispositions, identities, and perspectives)…

  4. Community garden: A bridging program between formal and informal learning

    Directory of Open Access Journals (Sweden)

    Ranjan Datta

    2016-12-01

    Full Text Available Community garden activities can play a significant role in bridging formal and informal learning, particularly in urban children’s science and environmental education. It promotes relational methods of learning, discussing, and practicing that will integrate food security, social interactions, community development, environmental activism, and cultural integration. Throughout the last five years of my community garden activities, I have learned that community garden-based practices adhere to particular forms of agency: embracing diversity, sharing power, and trust building as a part of everyday learning. My auto-ethnographic study provides valuable insights for environmental educators whose goals include, incorporating ethnic diversity as well as engaging children in research, ultimately leading to community action.

  5. Assessment of factors impacting success for incoming college engineering students in a summer bridge program

    Science.gov (United States)

    Reisel, John R.; Jablonski, Marissa; Hosseini, Hossein; Munson, Ethan

    2012-06-01

    A summer bridge program for incoming engineering and computer science freshmen has been used at the University of Wisconsin-Milwaukee from 2007 to 2010. The primary purpose of this program has been to improve the mathematics course placement for incoming students who initially place into a course below Calculus I on the math placement examination. The students retake the university's math placement examination after completing the bridge program to determine if they then place into a higher-level mathematics course. If the students improve their math placement, the program is considered successful for that student. The math portion of the bridge program is designed around using the ALEKS software package for targeted, self-guided learning. In the 2007 and 2008 versions of the program, both an on-line version and an on-campus version with additional instruction were offered. In 2009 and 2010, the program was exclusively in an on-campus format, and also featured a required residential component and additional engineering activities for the students. From the results of these four programs, we are able to evaluate the success of the program in its different formats. In addition, data has been collected and analysed regarding the impact of other factors on the program's success. The factors include student preparation before the beginning of the program (as measured by math ACT scores) and the amount of time the student spent working on the material during the program. Better math preparation and the amount of time spent on the program were found to be good indicators of success. Furthermore, the on-campus version of the program is more effective than the on-line version.

  6. Bridging the Scholar-Practitioner Gap: The San Antonio Export Leaders Program

    Science.gov (United States)

    Jackson, Sara C.

    2013-01-01

    Bridging the gap between theory and practice enables trade service providers to effectively reach the small business community interested in entering foreign markets. This paper describes how the award-winning San Antonio Export Leaders program is a model for applying theoretical concepts to the practice of international business.

  7. A Summer Bridge Program for Underprepared First-Year Students: Confidence, Community, and Re-Enrollment

    Science.gov (United States)

    Suzuki, Anne; Amrein-Beardsley, Audrey; Perry, Nancy J.

    2012-01-01

    This quasi-experimental, action-research study explored a five-week pre-enrollment initiative called the Pathways Summer Bridge (PSB) Program in the New College of Interdisciplinary Arts and Sciences at Arizona State University (ASU). Theoretically framed and developed using the six components of Tinto's (1993) longitudinal model of institutional…

  8. Effectiveness of University Bridging Programs in Preparing Students for University Education: A Case from East Africa

    Science.gov (United States)

    Ssempebwa, Jude; Eduan, Wilson; Mulumba, Fawz Nassir

    2012-01-01

    Study abroad brings several advantages to students, universities, countries, and academe. However, across countries with incongruent preuniversity education structures, some students are denied admission to foreign universities, due to gaps in their admissibility. Some institutions offer university bridging programs, to enhance the admissibility…

  9. Passing the Torch: Preparing Teaching Artists through a First-Year ArtsBridge Program

    Science.gov (United States)

    Kaufmann, Karen A.

    2007-01-01

    During spring, 2005 The University of Montana, Department of Drama/Dance successfully piloted a small ArtsBridge Program through a new service-learning course for advanced dance and drama students. This article describes the process of setting up the university-public school partnership; describes challenges to faculty, staff, scholars and host…

  10. Multilevel Resistance Programming in Conductive Bridge Resistive Memory

    Science.gov (United States)

    Mahalanabis, Debayan

    This work focuses on the existence of multiple resistance states in a type of emerging non-volatile resistive memory device known commonly as Programmable Metallization Cell (PMC) or Conductive Bridge Random Access Memory (CBRAM), which can be important for applications such as multi-bit memory as well as non-volatile logic and neuromorphic computing. First, experimental data from small signal, quasi-static and pulsed mode electrical characterization of such devices are presented which clearly demonstrate the inherent multi-level resistance programmability property in CBRAM devices. A physics based analytical CBRAM compact model is then presented which simulates the ion-transport dynamics and filamentary growth mechanism that causes resistance change in such devices. Simulation results from the model are fitted to experimental dynamic resistance switching characteristics. The model designed using Verilog-a language is computation-efficient and can be integrated with industry standard circuit simulation tools for design and analysis of hybrid circuits involving both CMOS and CBRAM devices. Three main circuit applications for CBRAM devices are explored in this work. Firstly, the susceptibility of CBRAM memory arrays to single event induced upsets is analyzed via compact model simulation and experimental heavy ion testing data that show possibility of both high resistance to low resistance and low resistance to high resistance transitions due to ion strikes. Next, a non-volatile sense amplifier based flip-flop architecture is proposed which can help make leakage power consumption negligible by allowing complete shutdown of power supply while retaining its output data in CBRAM devices. Reliability and energy consumption of the flip-flop circuit for different CBRAM low resistance levels and supply voltage values are analyzed and compared to CMOS designs. Possible extension of this architecture for threshold logic function computation using the CBRAM devices as re

  11. Towards Bridging the Gap Programming Language and Partial Evaluation

    DEFF Research Database (Denmark)

    Le Meur, Anne-Francoise; Lawall, Julia Laetitia; Consel, Charles

    2002-01-01

    to guide the choice of both the code to specialize and the invariants to exploit during the specialization process. To ease the use of partial evaluation, the syntax of this language is similar to the declaration syntax of the target language of the partial evaluator. To provide feedback to the programmer......, declarations are checked throughout the analyses performed by partial evaluation. The language has been successfully used by a signal-processing expert in the design of a specializable Forward Error Correction component.......Partial evaluation is a program-transformation technique that automatically specializes a program with respect to user-supplied invariants. Despite successful applications in areas such as graphics, operating systems, and software engineering, partial evaluators have yet to achieve widespread use...

  12. Columbia's Bridge to the Ph.D. Program: A research-focused initiative facilitating the transition to graduate school

    Science.gov (United States)

    Agüeros, Marcel A.

    2015-01-01

    Columbia University's Bridge to the Ph.D. in the Natural Sciences Program aims to enhance the participation of students from underrepresented groups in Ph.D. programs. To achieve this, the Bridge Program provides an intensive research, coursework, and mentoring experience to post-baccalaureates seeking to strengthen their graduate school applications and to prepare for the transition into graduate school. To date, 20 Bridge Program alumni --- including four in astronomy --- have gone on to Ph.D. programs at Columbia, the University of Michigan, Johns Hopkins, the University of Washington, Albert Einstein, Yale, and SUNY-Albany, among others. In this talk, I will touch on some of the connections between Pre-MAP and the Bridge Program, and particularly how my involvement in the former prepared me to lead the latter.

  13. Attitudes Towards PrEP and Anticipated Condom Use Among Concordant HIV-Negative and HIV-Discordant Male Couples.

    Science.gov (United States)

    Hoff, Colleen C; Chakravarty, Deepalika; Bircher, Anja E; Campbell, Chadwick K; Grisham, Kirk; Neilands, Torsten B; Wilson, Patrick A; Dworkin, Shari

    2015-07-01

    Since the July 2012 approval by the FDA of emtricitabine/ tenofovir disoproxil fumarate (Truvada) for use as pre-exposure prophylaxis (PrEP) against HIV, its feasibility and acceptability has been under study. HIV-discordant couples are likely targets for PrEP but little is known about how this new prevention tool impacts relationships. We examined, among gay male couples, the acceptability of individual and partner use of PrEP and intentions to use condoms with primary and outside partners in the context of PrEP use. Data are from two independent samples of couples recruited in the San Francisco bay area and New York City-a qualitative one (N=48 couples) between March and November, 2011, and a quantitative one (N=171 couples) between June, 2012 and May, 2013. Data were categorized by couple HIV status and general linear models; chi-square tests of independence were used to examine condom-use intentions with primary and outside partners, by sexual risk profile, and race. Almost half of the HIV-negative couples felt PrEP was a good HIV prevention strategy for themselves and their partner. Over half reported that they would not change their current condom use if they or their partner were taking PrEP. However, approximately 30% of HIV-negative couples reported that they would stop using condoms or use them less with primary and outside partners if they were on PrEP or if their partner was on PrEP. A large percentage of couples view PrEP positively. However, to ensure safety for both partners, future programing must consider those who intend not to use condoms while on PrEP.

  14. Framing HIV Pre-Exposure Prophylaxis (PrEP) for the General Public: How Inclusive Messaging May Prevent Prejudice from Diminishing Public Support.

    Science.gov (United States)

    Calabrese, Sarah K; Underhill, Kristen; Earnshaw, Valerie A; Hansen, Nathan B; Kershaw, Trace S; Magnus, Manya; Krakower, Douglas S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

    2016-07-01

    Strategic framing of public messages about HIV pre-exposure prophylaxis (PrEP) may influence public support for policies and programs affecting access. This survey study examined how public attitudes toward PrEP differed based on the social group PrEP was described as benefiting ("beneficiary") and the moderating effect of prejudice. Members of the general public (n = 154) recruited online were randomly assigned to three beneficiary conditions: general population, gay men, or Black gay men. All participants received identical PrEP background information before completing measures of PrEP attitudes (specifying beneficiary), racism, and heterosexism. Despite anticipating greater PrEP adherence among gay men and Black gay men and perceiving PrEP as especially beneficial to the latter, participants expressed lower support for policies/programs making PrEP affordable for these groups vs. the general population. This disparity in support was stronger among participants reporting greater prejudice. Inclusive framing of PrEP in public discourse may prevent prejudice from undermining implementation efforts.

  15. PrEP: controversy, agency and ownership

    National Research Council Canada - National Science Library

    Cairns, Gus P; Race, Kane; Goicochea, Pedro

    2016-01-01

    Pre‐exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need...

  16. Pre-Exposure Prophylaxis (PrEP)

    Science.gov (United States)

    ... Sites Podcasts QR Codes RSS Feeds Social Bookmarking Social Network Sites Text Messaging Twitter Video Games Video Sharing ... PrEP be considered for people who are HIV-negative and at very high risk for HIV infection . ...

  17. PrEP: controversy, agency and ownership

    OpenAIRE

    Cairns, Gus P; Kane Race; Pedro Goicochea

    2016-01-01

    Pre-exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need of it. These controversies extend beyond the intrinsically complex issues of making it available. In this commentary, some of the possible roots of the air of dissent and drama that accompanies PrEP are explored. The similarities between the controversies that dogged the earliest human tr...

  18. Computerized fracture critical and specialized bridge inspection program with NDE applications

    Science.gov (United States)

    Fish, Philip E.

    1998-03-01

    Wisconsin Department of Transportation implemented a Fracture Critical & Specialized Inspection Program in 1987. The program has a strong emphasis on Nondestructive Testing (NDT). The program is also completely computerized, using laptop computers to gather field data, digital cameras for pictures, and testing equipment with download features. Final inspection reports with detailed information can be delivered within days of the inspection. The program requires an experienced inspection team and qualified personnel. Individuals performing testing must be licensed ASNT (American Society for Nondestructive Testing) Level III and must be licensed Certified Weld Inspectors (American Welding Society). Several critical steps have been developed to assure that each inspection identifies all possible deficiencies that may be possible on a Fracture Critical or Unique Bridge. They include; review of all existing plans and maintenance history; identification of fracture critical members, identification of critical connection details, welds, & fatigue prone details, development of visual and NDE inspection plan; field inspection procedures; and a detailed formal report. The program has found several bridges with critical fatigue conditions which have resulted in replacement or major rehabilitation. In addition, remote monitoring systems have been installed on structures with serious cracking to monitor for changing conditions.

  19. Bridging the Gap Between Theory and Practice in a B.A. Program in EFL

    Directory of Open Access Journals (Sweden)

    Julia Zoraida Posada Ortiz

    2014-04-01

    Full Text Available This article describes the theoretical principles underlying the research component of the Bachelor’s program of Basic Education with an Emphasis in English at a public university in Bogotá (Colombia, and an exercise of syllabus revision that served to link theory and practice through the research component of the program. The aim of the exercise was to reflect upon the syllabus and discuss how, from the different components of the program, student-teachers can understand research as the bridge to link what they learn in class and their practice in school contexts. A group of teachers revised the theoretical foundations as well as their practice in each cycle of the program, using the main tenets of critical pedagogy, teacher research, reflective teaching, and case study.

  20. Gifted Students' Views about First Stage of the Education Program for the Gifted Students' Bridge with University (EPGBU)

    Science.gov (United States)

    Tortop, Hasan Said

    2014-01-01

    All over the world, studies related to design of appropriate educational programs for gifted students are continuing. It is also important that these programs should be adapted to developing educational technologies. In Turkey, the structure of the Education Program for the Gifted Students' Bridge with University (EPGBU) which has been prepared…

  1. Urban Climate Change Resilience as a Teaching Tool for a STEM Summer Bridge Program

    Science.gov (United States)

    Rosenzweig, B.; Vorosmarty, C. J.; Socha, A.; Corsi, F.

    2015-12-01

    Community colleges have been identified as important gateways for the United States' scientific workforce development. However, students who begin their higher education at community colleges often face barriers to developing the skills needed for higher-level STEM careers, including basic training in mathematics, programming, analytical problem solving, and cross-disciplinary communication. As part of the Business Higher Education Forum's Undergraduate STEM Interventions in Industry (USI2) Consortium, we are developing a summer bridge program for students in STEM fields transferring from community college to senior (4-year) colleges at the City University of New York. Our scientific research on New York City climate change resilience will serve as the foundation for the bridge program curriculum. Students will be introduced to systems thinking and improve their analytical skills through guided problem-solving exercises using the New York City Climate Change Resilience Indicators Database currently being developed by the CUNY Environmental Crossroads Initiative. Students will also be supported in conducting an introductory, independent research project using the database. The interdisciplinary nature of climate change resilience assessment will allow students to explore topics related to their STEM field of interest (i.e. engineering, chemistry, and health science), while working collaboratively across disciplines with their peers. We hope that students that participate in the bridge program will continue with their research projects through their tenure at senior colleges, further enhancing their academic training, while actively contributing to the study of urban climate change resilience. The effectiveness of this approach will be independently evaluated by NORC at the University of Chicago, as well as through internal surveying and long-term tracking of participating student cohorts.

  2. Bridging Differences -- how Social Relationships and Racial Diversity Matter in a Girls' Technology Program

    Science.gov (United States)

    Kekelis, Linda S.; Ancheta, Rebecca Wepsic; Heber, Etta; Countryman, Jeri

    In this article, we explore an understudied dimension of girls' single-sex education - how social relationships and racial diversity impact the educational environment for girls, and how teachers may best address these concerns. Findings are presented from a 3-year qualitative study of girls' experiences in a single-sex technology program. Girls valued the all-girls aspect of the programs, and friendships formed the foundation of their social experiences. Girls' friendship groups influenced their experiences and eventually their success in the after school technology programs. When friendship groups were observed to be racially homogeneous, they created challenges for including and supporting a racially diverse student membership. Our responses to the challenges that cultural differences and tensions present are outlined, along with recommendations for helping girls bridge these differences.

  3. Prep/Tech: Volume 1, No. 1, Youth on homelessness

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    PREP/TECH is a skill development, academic enrichment program of U. of Toledo in Toledo OH and The Engineers Foundation of Ohio; it addresses the mathematics, science, language, and intellectual needs of about 100 African-American and Hispanic-American 7th, 8th, and 9th graders in Toledo. This summer, after 3 weeks of classes, the 80 students returned for a second 3 week session and were divided into two groups, one studying the growing problem of homelessness in America. This group researched and published a pamphlet on homelessness. This report is divided into: myths, causes, descriptions, and solutions. Finally, a brief account is given of the homelessness project.

  4. A New Model Program for Academically Gifted Students in Turkey: Overview of the Education Program for the Gifted Students' Bridge with University (EPGBU)

    Science.gov (United States)

    Tortop, Hasan Said

    2013-01-01

    All over the world, studies related to design of appropriate educational programs for gifted students have been continuing. It is also important that these programs should be adapted to both realities of countries and developing educational technologies. In Turkey, the structure of The Education Program for the Gifted Students' Bridge with…

  5. PrEP (Pre-Exposure Prophylaxis) 101

    Science.gov (United States)

    ... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

  6. Summer Professional Development in Chemistry for Inservice Teachers Using OWL Quick Prep

    Science.gov (United States)

    Powell, Cynthia B.; Pamplin, Kim L.; Blake, Robert E.; Mason, Diana S.

    2010-01-01

    Secondary teachers participating in summer professional development chemistry workshops in Texas used an online chemistry tutoring program, OWL Quick Prep (Day et al. in OWL: Online Web-based Learning, Brooks-Cole Cengage Learning, Florence, KY, 1997) as a part of the inservice training. Self-reported demographic data were used to identify factors…

  7. Bridging the Gap between NASA Earth Observations and Decision Makers through the NASA DEVELOP National Program

    Science.gov (United States)

    Favors, J. E.; Childs-Gleason, L. M.; Ross, K. W.; Rogers, L.; Allsbrook, K. N.; Ruiz, M. L.; Miller, T. N.; Crepps, G.

    2015-12-01

    The NASA DEVELOP National Program bridges the gap between NASA Earth Science and society by building capacity in both participants and partner organizations who collaborate to conduct projects. These rapid feasibility projects highlight the capabilities of satellite and aerial Earth observations to enhance decision making on a local level. DEVELOP partners with a wide variety of organizations, including state and local governments, federal agencies, regional entities, tribal governments, international organizations and governments, NGOs and private companies. Immersion of decision and policy makers in these feasibility projects increases awareness of the capabilities of Earth observations, and contributes to the tools and resources available to support enhanced decision making. This presentation will highlight best practices, feedback from project end-users, and case studies of successful adoption of methods in the decision making process.

  8. Bridging the Gap Between NASA Earth Observations and Decision Makers Through the NASA Develop National Program

    Science.gov (United States)

    Remillard, C. M.; Madden, M.; Favors, J.; Childs-Gleason, L.; Ross, K. W.; Rogers, L.; Ruiz, M. L.

    2016-06-01

    The NASA DEVELOP National Program bridges the gap between NASA Earth Science and society by building capacity in both participants and partner organizations that collaborate to conduct projects. These rapid feasibility projects highlight the capabilities of satellite and aerial Earth observations. Immersion of decision and policy makers in these feasibility projects increases awareness of the capabilities of Earth observations and contributes to the tools and resources available to support enhanced decision making. This paper will present the DEVELOP model, best practices, and two case studies, the Colombia Ecological Forecasting project and the Miami-Dade County Ecological Forecasting project, that showcase the successful adoption of tools and methods for decision making. Through over 90 projects each year, DEVELOP is always striving for the innovative, practical, and beneficial use of NASA Earth science data.

  9. NDE applications in an anchor bolt and sign bridge inspection program

    Science.gov (United States)

    Fish, Philip E.

    1998-03-01

    Wisconsin Department of Transportation implemented an Anchor Bolt Inspection Program and Sign Bridge Inspection Program in 1990 for cantilever & overhead sign structures, high mast light towers, interstate light towers, and signal masts. All cantilever & overhead sign structures and high mast light towers have been inspected in-depth 'hands on' during this time period while implementation of inspection continues for interstate light towers and signal masts. The program requires an experienced inspection team and a practical inspection approach. Inspection preparation includes review of all background information such as design plans, design computations, construction plans, shop plans, and maintenance history. An inspection plan is developed. Special emphasis is placed on determining type of structure, type of material, welding details. For anchor bolts, type of material, cut or rolled threads, type of coating, and method of placement are important issues. Inspection emphasis are on 'hands on' and Nondestructive evaluation. Special emphasis is placed visual conditions of sign structures and anchor bolts (cut or rolled threads, straightness, corrosion, nut tension, etc.) along with ultrasonic inspection. This program places a strong emphasis on Non Destructive Testing (NDT), especially ultrasonic. Procedures and inspection calibrations for anchor bolts, are developed from similar anchor bolt geometry and material type. Cut notches are placed in the anchor bolts at locations of possible failure. NDT inspection calibrations are performed from these bolts. Report documentation includes all design plans, pictorial documentation of structural deficiencies, sketches, nondestructive evaluation reports, conclusions, and recommendations. This program has been successful in locating critical cracks and failed members on existing sign structures and new sign structures less than six months old. Also, failed anchor bolts and critical cracks have been located on high mast light

  10. Bridges self-management program for people with stroke in the community: A feasibility randomized controlled trial.

    Science.gov (United States)

    McKenna, Suzanne; Jones, Fiona; Glenfield, Pauline; Lennon, Sheila

    2015-07-01

    Enabling self-management behaviors is considered important in order to develop coping strategies and confidence for managing life with a long-term condition. However, there is limited research into stroke-specific self-management interventions. The aim of this randomized controlled trial was to evaluate the feasibility of delivering the Bridges stroke self-management program in addition to usual stroke rehabilitation compared with usual rehabilitation only. Participants recruited from the referrals to a community stroke team were randomly allocated to the Bridges stroke self-management program, receiving either one session of up to one-hour per week over a six-week period in addition to usual stroke rehabilitation, or usual rehabilitation only. Feasibility was measured using a range of methods to determine recruitment and retention; adherence to the program; suitability and variability of outcome measures used; application and fidelity of the program; and acceptability of the program to patients, carers and professionals. Twenty-five people were recruited to the study over a 13-month period. Eight out of the 12 participants in the Bridges stroke self-management program received all six sessions; there was one withdrawal from the study. There were changes in outcomes between the two groups. Participants who received the Bridges stroke self-management program appeared to have a greater change in self-efficacy, functional activity, social integration and quality of life over the six-week intervention period and showed less decline in mood and quality of life at the three-month follow-up. Professionals found the program acceptable to use in practice, and feedback from participants was broadly positive. The findings from this study appear promising, but questions remain regarding the feasibility of delivering the Bridges stroke self-management program in addition to usual rehabilitation. The dose response of receiving the program cannot be ruled out, and the next stage

  11. The Cal-Bridge Program: Increasing the Gender and Ethnic Diversity of Astrophysics Students in Southern California

    Science.gov (United States)

    Smecker-Hane, Tammy A.; Rudolph, Alexander L.

    2016-06-01

    The mission of the Cal-Bridge program is to increase the number of underrepresented minority and women students completing a bachelor’s degree and entering a PhD program in astronomy, physics, or closely-related fields. The program has created a network of faculty at diverse higher education institutions, including 5 University of California (UC) campuses, 9 California State Universities (CSUs), and 10 community colleges in southern California, dedicated to this goal. Students selected for the program are know as “Cal-Bridge Scholars” and they are given a wide variety of support: (1) scholarships in their junior/senior years at CSU and their first year of graduate school at a UC, (2) intensive mentoring by a pair of CSU and UC faculty members, (3) tutoring, when needed, (4) professional development workshops, (5) exposure to research opportunities at various universities, and (6) membership in a growing cohort of like-minded students. We report on the structure of our program, lessons learned with our current 12 Cal-Bridge scholars, and the results of our first two years of operation. Funding for this program is provided by NSF-SSTEM Grant #1356133.

  12. The BRIGHTEN Program: Implementation and Evaluation of a Program to Bridge Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking

    Science.gov (United States)

    Emery, Erin E.; Lapidos, Stan; Eisenstein, Amy R.; Ivan, Iulia I.; Golden, Robyn L.

    2012-01-01

    Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually"…

  13. The BRIGHTEN Program: Implementation and Evaluation of a Program to Bridge Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking

    Science.gov (United States)

    Emery, Erin E.; Lapidos, Stan; Eisenstein, Amy R.; Ivan, Iulia I.; Golden, Robyn L.

    2012-01-01

    Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually"…

  14. Program on Promoting Climate Change Adaptation Technologies Bridging Policy Making and Science Research in Taiwan

    Science.gov (United States)

    Chiang, Y.; Chiang, W.; Sui, C.; Tung, C.; Ho, H.; Li, M.; Chan, S.; Climate Change Adaptation Technologies Program, National Science Council, Taiwan

    2010-12-01

    Climate changes adaptation needs innovative technological revolution on demand for transdisciplinary studies in various temporal and spatial scales. In our proposed program, a systematic and scientific framework will be developed to promote innovative adaptation technologies with respect to providing decision making information for government sectors, enhancing applicability of scientific research output, strengthening national research capabilities, and integrating both academic and non-academic resources. The objectives of this program are to identify key issues, required technologies, and scientific knowledge for climate change adaptations, and to build a transdisciplinary platform bridging science-supported technologies required by government sectors and demand-oriented scientific research conducted by academic communities. The approach proposed herein will be practiced in vulnerable regions, such as urban, rural, mountain, river basin, and coastal areas, which are particularly sensitive to climate change. The first phase of 3-year (2011~2013) work is to deploy framework and strategies of climate change impact assessment and adaptation measures between related government sectors and researchers from academic communities. The proposed framework involves three principle research groups, namely Environmental System, Vulnerability Assessment, and Risk Management and Adaptation Technology. The goal of the first group, Environmental System, is to combine climate change projections with enhanced scientific and environmental monitoring technologies for better adaptations to future scenarios in different social, economic, and environmental sectors to support adaptation measures planning and to reduce uncertainties on assessing vulnerability. The goal of the second group, Vulnerability Assessment, is to identify interfaces and information structures of climate change vulnerably issues and to develop protocol, models, and indices for vulnerability assessment. The goal of

  15. How To Start a Prep Physics Course

    Science.gov (United States)

    Wall, Jesse D.

    1998-04-01

    At City College, we follow our mother institution, the University of California at Berkeley, in that we require high school physics as a prerequisite for general college physics and then provide a one-semester prep physics course as an alternative to meet this prerequisite. Many people have asked me how they can start such a course. In traveling about on my sabbatical, doing Physics Of Magic (1) at various schools, I have observed how various schools implement this prerequisite course. I will discuss my observations.

  16. PreP+07: improvements of a user friendly tool to preprocess and analyse microarray data

    Directory of Open Access Journals (Sweden)

    Claros M Gonzalo

    2009-01-01

    Full Text Available Abstract Background Nowadays, microarray gene expression analysis is a widely used technology that scientists handle but whose final interpretation usually requires the participation of a specialist. The need for this participation is due to the requirement of some background in statistics that most users lack or have a very vague notion of. Moreover, programming skills could also be essential to analyse these data. An interactive, easy to use application seems therefore necessary to help researchers to extract full information from data and analyse them in a simple, powerful and confident way. Results PreP+07 is a standalone Windows XP application that presents a friendly interface for spot filtration, inter- and intra-slide normalization, duplicate resolution, dye-swapping, error removal and statistical analyses. Additionally, it contains two unique implementation of the procedures – double scan and Supervised Lowess-, a complete set of graphical representations – MA plot, RG plot, QQ plot, PP plot, PN plot – and can deal with many data formats, such as tabulated text, GenePix GPR and ArrayPRO. PreP+07 performance has been compared with the equivalent functions in Bioconductor using a tomato chip with 13056 spots. The number of differentially expressed genes considering p-values coming from the PreP+07 and Bioconductor Limma packages were statistically identical when the data set was only normalized; however, a slight variability was appreciated when the data was both normalized and scaled. Conclusion PreP+07 implementation provides a high degree of freedom in selecting and organizing a small set of widely used data processing protocols, and can handle many data formats. Its reliability has been proven so that a laboratory researcher can afford a statistical pre-processing of his/her microarray results and obtain a list of differentially expressed genes using PreP+07 without any programming skills. All of this gives support to scientists

  17. Potential reduced exposure products (PREPs) in industry trial testimony.

    Science.gov (United States)

    Wayne, Geoffrey Ferris

    2006-12-01

    To identify patterns in trial testimony that may reflect on the intentions or expectations of tobacco manufacturers with regard to the introduction of potential reduced exposure products (PREPs). Research was conducted using the Deposition and Trial Testimony Archive (DATTA) collection of trial testimony and depositions housed online at Tobacco Documents Online (www.tobaccodocuments.org). Relevant testimony was identified through full-text searches of terms indicating PREPs or harm reduction strategies. The role and function of PREPs in testimony were classified according to common and contrasting themes. These were analysed in the context of broader trial arguments and against changes in time period and the market. Analysis of testimony suggests that the failure of PREPs in the market tempered initial industry enthusiasm and made protection of the conventional cigarette market its major priority. The "breakthrough" character of PREPs has been de-emphasised, with trial arguments instead positioning PREPs as simply another choice for consumers. This framework legitimises the sale of conventional brands, and shifts the responsibility for adoption of safer products from the manufacturer to the consumer. Likewise, testimony has abandoned earlier dramatic health claims made with regard to PREPs, which had undermined industry arguments regarding efforts to reduce harm in conventional products. More recent testimony advocates the broad acceptance of independent guidelines that would validate use of health claims and enable the industry to market PREPs to consumers. Trial testimony reflects the changing role and positioning of PREPs by the tobacco industry. The findings are of particular importance with regard to future evaluation and potential regulation of reduced harm products.

  18. Tailored combination prevention packages and PrEP for young key populations

    Directory of Open Access Journals (Sweden)

    Audrey Pettifor

    2015-02-01

    discrimination, and fostering community empowerment. PrEP could offer a highly effective, time-limited primary prevention for young key populations if it is implemented in combination with other programs to increase access to health services and encourage the reliable use of PrEP while at risk of HIV exposure. Conclusions: Reductions in HIV incidence will only be achieved through the implementation of combinations of interventions that include biomedical and behavioural interventions, as well as components that address social, economic and other structural factors that influence HIV prevention and transmission.

  19. Bridging Bilingual and Special Education: Opportunities for Transformative Change in Teacher Preparation Programs

    Science.gov (United States)

    Ochoa, Alberto M.; Brandon, Regina R.; Cadiero-Kaplan, Karen; Ramírez, Pablo C.

    2014-01-01

    This article reports on the design and performance of ALAS (Acquisition of Language Skills and Academic Literacy) Teacher Education Project designed to bridge Biliteracy and Special Education teacher preparation. ALAS was designed by faculty in two higher education departments engaged in teacher preparation to respond to California's need for…

  20. Simple Program to Investigate Hysteresis Damping Effect of Cross-Ties on Cables Vibration of Cable-Stayed Bridges

    Directory of Open Access Journals (Sweden)

    Panagis G. Papadopoulos

    2012-01-01

    Full Text Available A short computer program, fully documented, is presented, for the step-by-step dynamic analysis of isolated cables or couples of parallel cables of a cable-stayed bridge, connected to each other and possibly with the deck of the bridge, by very thin pretensioned wires (cross-ties and subjected to variation of their axial forces due to traffic or to successive pulses of a wind drag force. A simplified SDOF model, approximating the fundamental vibration mode, is adopted for every individual cable. The geometric nonlinearity of the cables is taken into account by their geometric stiffness, whereas the material nonlinearities of the cross-ties include compressive loosening, tensile yielding, and hysteresis stress-strain loops. Seven numerical experiments are performed. Based on them, it is observed that if two interconnected parallel cables have different dynamic characteristics, for example different lengths, thus different masses, weights, and geometric stiffnesses, too, or if one of them has a small additional mass, then a single pretensioned very thin wire, connecting them to each other and possibly with the deck of the bridge, proves effective in suppressing, by its hysteresis damping, the vibrations of the cables.

  1. Increasing Diversity in STEM through Ka Hikina O Ka Lā Summer Bridge Program for Native Hawaiian Students

    Science.gov (United States)

    Coopersmith, A.; Cie, D. K.; Calder, S.; Naho`olewa, D.; Rai, B.

    2014-12-01

    The Advanced Technology Solar Telescope (ATST) Mitigation Initiative and the Kahikina O Ka Lā Program are NSF-funded projects at the University of Hawai`i Maui College. These projects offer instruction and activities intended to increase diversity in STEM careers. Ke Alahaka, the 2014 summer bridge program, was offered to Native Hawaiian high-school students who indicated an interest in STEM areas. Content workshops were offered in Marine Science, Physics, Biotechnology, and Computer Science and Engineering as well as a Hawaiian Studies course designed to provide a cultural context for the STEM instruction. Focus groups and other program assessments indicate that 50% of the students attending the workshops intend to pursue a STEM major during their undergraduate studies.

  2. PrEP implementation research in Africa: what is new?

    Directory of Open Access Journals (Sweden)

    Frances M Cowan

    2016-10-01

    Full Text Available Introduction: Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM, transgender women and injection drug users are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion: In each of the target populations, there are overarching issues related to (i creating demand for PrEP, (ii addressing supply-side issues and (iii providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely

  3. Plastic Bridge

    Institute of Scientific and Technical Information of China (English)

    履之

    1994-01-01

    Already ubiquitous in homes and cars, plastic is now appearing inbridges. An academic-industrial consortium based at the University ofCalifornia in San Diego is launching a three-year research program aimed atdeveloping the world’s first plastic highway bridge, a 450-foot span madeentirely from glass-,carbon,and polymer-fiber-reinforced composite mate-rials, the stuff of military aircraft. It will cross Interstate 5 to connect thetwo sides of the school’s campus.

  4. AirfoilPrep.py Documentation: Release 0.1.0

    Energy Technology Data Exchange (ETDEWEB)

    Ning, S. A. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-09-01

    AirfoilPrep.py provides functionality to preprocess aerodynamic airfoil data. Essentially, the module is an object oriented version of the AirfoilPrep spreadsheet with additional functionality and is written in the Python language. It allows the user to read in two-dimensional aerodynamic airfoil data, apply three-dimensional rotation corrections for wind turbine applications, and extend the datato very large angles of attack. This document discusses installation, usage, and documentation of the module.

  5. The effects of a prenatal course including PREP for effective family living on self-esteem and parenting attitudes of adolescents: a brief report.

    Science.gov (United States)

    Emmons, R D; Nystul, M S

    1994-01-01

    Nine adolescent females were enrolled in a prenatal course that included the PREP for Effective Family Living Program (the treatment group). Two comparison groups were utilized in this study; one attended the prenatal group without the PREP program, and the second did not attend either the prenatal course or the PREP program. The Coopersmith Self-Esteem Inventory and the Attitude Toward the Freedom of Children Scale (a parental attitude scale) was administered to all participants. No significant difference was found among the three groups in terms of self-concept. A significant difference was found among the three groups in terms of parental attitudes, with the treatment group scoring higher on democratic parenting attitudes than did the two comparison groups.

  6. Marketing a Wellness Program: A Case Study in Bridging the Gap between Academic and Student Affairs.

    Science.gov (United States)

    Dod, Glenna A.; Earwood-Smith, Glenda

    1988-01-01

    Reports on a collaborative effort between a student services division and a classroom instructor aimed at increasing student involvement in marketing a wellness program for college students. Claims program was successful in improving attendance at the wellness program and changing attitudes towards this type of programing. (Author/ABL)

  7. Pedagogy and Processes for a Computer Programming Outreach Workshop--The Bridge to College Model

    Science.gov (United States)

    Tangney, Brendan; Oldham, Elizabeth; Conneely, Claire; Barrett, Stephen; Lawlor, John

    2010-01-01

    This paper describes a model for computer programming outreach workshops aimed at second-level students (ages 15-16). Participants engage in a series of programming activities based on the Scratch visual programming language, and a very strong group-based pedagogy is followed. Participants are not required to have any prior programming experience.…

  8. MARS therapy, the bridging to liver retransplantation – Three cases from the Hungarian liver transplant program

    Science.gov (United States)

    Fazakas, János; Zádori, Gergely; Görög, Dénes; Kóbori, László; Dabasi, Eszter; Mándli, Tamás; Piros, László; Smudla, Anikó; Szabó, Tamás; Toronyi, Éva; Tóth, Szabolcs; Tőzsér, Gellért; Végső, Gyula; Doros, Attila; Nemes, Balázs

    2013-01-01

    Besides orthotopic liver transplantation (OLT) there is no long-term and effective replacement therapy for severe liver failure. Artificial extracorporeal liver supply devices are able to reduce blood toxin levels, but do not replace any synthetic function of the liver. Molecular adsorbent recirculating system (MARS) is one of the methods that can be used to treat fulminant acute liver failure (ALF) or acute on chronic liver failure (AoCLF). The primary non-function (PNF) of the newly transplanted liver manifests in the clinical settings exactly like acute liver failure. MARS treatment can reduce the severity of complications by eliminating blood toxins, so that it can help hepatic encephalopathy (HE), hepatorenal syndrome (HRS), and the high rate mortality of cerebral herniation. This might serve as a bridging therapy before orthotopic liver retransplantation (reOLT). Three patients after a first liver transplantation became candidate for urgent MARS treatment as a bridging solution prior to reOLT in our center. Authors report these three cases, fo-cusing on indications, MARS sessions, clinical courses, and final outcomes. PMID:24265893

  9. Using a visual programming language to bridge the cognitive gap between a novice's mental model and program code

    Science.gov (United States)

    Smith, Bryan J.

    Current research suggests that many students do not know how to program very well at the conclusion of their introductory programming course. We believe that a reason novices have such difficulties learning programming is because engineering novices often learn through a lecture format where someone with programming knowledge lectures to novices, the novices attempt to absorb the content, and then reproduce it during exams. By primarily appealing to programming novices who prefer to understand visually, we research whether programming novices understand programming better if computer science concepts are presented using a visual programming language than if these programs are presented using a text-based programming language. This method builds upon previous research that suggests that most engineering students are visual learners, and we propose that using a flow-based visual programming language will address some of the most important and difficult topics to novices of programming. We use an existing flow-model tool, RAPTOR, to test this method, and share the program understanding results using this theory.

  10. PREP advertisement features affect smokers' beliefs regarding potential harm.

    Science.gov (United States)

    Strasser, A A; Tang, K Z; Tuller, M D; Cappella, J N

    2008-09-01

    The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. To determine the effect of altering advertisement features on smokers' beliefs of the harm exposure from a PREP. A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a "red" condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a "no text" condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using "incorrect," "unsure" and "correct" as outcomes, and advertisement type and covariates as predictors, was used for analyses. Participants randomised to the "no text" advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, are healthier and make smoking safer. Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising.

  11. NEXT GENERATION ORAL PrEP: BEYOND TENOFOVIR

    Science.gov (United States)

    Abraham, Bisrat K.; Gulick, Roy

    2013-01-01

    Purpose Clinical trials of oral pre-exposure prophylaxis (PrEP) have focused testing on regimens of tenofovir (TDF) with or without emtricitabine (FTC). However, TDF may be associated with toxicities (renal, bone) and FTC may select for drug resistance. In this review, we discuss agents that might serve as alternatives to TDF/FTC for HIV prevention. Recent Findings Several drug characteristics are important to consider when selecting agents for PrEP with the most critical being safety, tolerability, adequate penetration into target tissues, prevention of HIV infection, and long lasting activity with convenient dosing. With these factors in mind, we review several potentially useful agents for PrEP. The first group includes drugs that are already FDA-approved (maraviroc, raltegravir) with attributes that make them attractive for PrEP. The second groups of drugs include investigational agents with long-lasting activities that are being developed in parenteral form (rilpivirine-long acting, S/GSK 1265744, ibalizumab). Summary Current research suggests there will be a broader array of PrEP drugs to choose from in the near future, thereby giving clinicians the flexibility to select agents that best suit the needs of their patient population. PMID:23032733

  12. Railroad Bridges

    Data.gov (United States)

    Department of Homeland Security — Bridges-Rail in the United States According to The National Bridge Inspection Standards published in the Code of Federal Regulations (23 CFR 650.3), a bridge isA...

  13. Building on the Success of Increasing Diversity in the Geosciences: A Bridging Program From Middle School to College

    Science.gov (United States)

    Kovacs, T.; Robinson, D.; Suleiman, A.; Maggi, B.

    2004-12-01

    A bridging program to increase the diversity in the geosciences was created at Hampton University (HU) to inspire underrepresented minorities to pursue an educational path that advances them towards careers in the geosciences. Three objectives were met to achieve this goal. First, we inspired a diverse population of middle and high school students outside of the classroom by providing an after school geoscience club, a middle school geoscience summer enrichment camp, and a research/mentorship program for high school students. Second, we helped fill the need for geoscience curriculum content requested of science teachers who work primarily with underrepresented middle school populations by providing a professional development workshop at HU led by geoscience professors, teachers, and science educators. Third, we built on the successful atmospheric sciences research and active Ph.D. program by developing our geoscience curriculum including the formation of a new space, earth, and atmospheric sciences minor. All workshops, camps, and clubs have been full or nearly full each year despite restrictions on participants repeating any of the programs. The new minor has 11 registered undergraduates and the total number of students in these classes has been increasing. Participants of all programs gave the quality of the program good ratings and participant perceptions and knowledge improved throughout the programs based on pre-, formative, and summative assessments. The ultimate goal is to increase the number of degrees granted to underrepresented minorities in the geosciences. We have built a solid foundation with our minor that prepares students for graduate degrees in the geosciences and offer a graduate degree in physics with a concentration in the atmospheric sciences. However, it's from the geoscience pipeline that students will come into our academic programs. We expect to continue to develop these formal and informal education programs to increase our reputation and

  14. Bridging the Generation Gap: A Rapid Early Career Hire Training Program

    Science.gov (United States)

    Rieber, Richard R.; Coffee, Thomas; Dong, Shuonan; Infield, Samantha I.; Kilbride, Kendra B.; Seibert, Michael A.; Solish, Benjamin S.

    2008-01-01

    This paper describes a training program to provide Early Career Hires (ECHs) in the aerospace industry with real, rapid, hands-on exposure to multiple phases and multiple disciplines of flight project development. Such a program has become necessary to close the Generation Gap and ensure that aerospace organizations maintain a highly skilled workforce as experienced personnel begin to retire. This paper discusses the specific motivations for and implementation of such a program at the Jet Propulsion Laboratory. However, the essential features are widely applicable to other NASA centers and organizations delivering large llight systems. This paper details the overall program concept, stages of participation by an ECH, oversight and mentoring, program assessment, training project selection, and facilities requirements.

  15. The Marriott Foundation's "Bridges...from School to Work" Program--A Framework for Successful Employment Outcomes for People with Disabilities.

    Science.gov (United States)

    Donovan, Mark R.; Tilson, George P., Jr.

    1998-01-01

    The Marriott Foundation's "Bridges" program is a transitional model designed to help people with disabilities find employment by matching skills with employer needs and creating a welcoming environment. Competitive paid work experience has a significant effect on vocational outcomes, and lasting relationships grow from complementary needs. (SK)

  16. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  17. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates

    NARCIS (Netherlands)

    K. Rozemeijer (Kirsten); C. Penning (Corine); A.G. Siebers (Albertus); S.K. Naber (Steffie); S.M. Matthijsse (Suzette); M. van Ballegooijen (Marjolein); F.J. van Kemenade (Folkert); I.M.C.M. de Kok (Inge)

    2016-01-01

    textabstractPurpose: Within the last decade, SurePath and ThinPrep [both liquid-based cytology (LBC) tests] have replaced conventional cytology (CC) as primary test method in cervical cancer screening programs of multiple countries. The aim of our study was to examine the effect in the Dutch screeni

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Resources in Surgical Education ACS Fundamentals of Surgery Curriculum Transition to Practice Program ACS/APDS Surgery Resident Skills Curriculum ACS/APDS/ASE Resident Prep Curriculum ACS/ASE ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... SESAP SESAP Sampler SRGS ACS Fundamentals of Surgery Curriculum Transition to Practice Program ACS/APDS Surgery Resident Skills Curriculum ACS/APDS/ASE Resident Prep Curriculum Medical Student ...

  20. New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA

    Science.gov (United States)

    Zucchelli, Chiara; Ferrari, Elena; Blasi, Francesco; Musco, Giovanna; Bruckmann, Chiara

    2017-01-01

    PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA binding. The kinetic parameters for DNA binding of individual PREP1 and PBX1 HDs, and of their combination, show that isolated PREP1 and PBX1 HDs bind to DNA in a cooperative manner. A novel PREP1 motif, flanking the HD at the C-terminus, is required for cooperativity. PMID:28094776

  1. Bridging the Otolaryngology Peer Review Knowledge Gap: A Call for a Residency Development Program.

    Science.gov (United States)

    Schmalbach, Cecelia E

    2016-07-01

    Current otolaryngology literature and future scientific direction rely heavily on a rigorous peer review process. Just as manuscripts warrant thoughtful review with constructive feedback to the authors, the same can be said for critiques written by novice peer reviewers. Formal scientific peer review training programs are lacking. Recognizing this knowledge gap, Otolaryngology-Head and Neck Surgery is excited to offer its new Resident Reviewer Development Program. All otolaryngology residents who are postgraduate year 2 and above and in excellent academic standing are eligible to participate in this mentored program, during which they will conduct 6 manuscript reviews under the direction of a seasoned reviewer in his or her subspecialty area of interest. By completing reviews alongside a mentor, participants gain the required skills to master the peer review process-a first step that often leads to journal editorial board and associate editor invitations.

  2. SPC-Prep. Instructor's Guide. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This instructor's guide contains materials for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform SPC…

  3. SPC-Prep 1. Participant's Manual. Workplace Education. Project ALERT.

    Science.gov (United States)

    Ruetz, Nancy

    This companion document to the instructor's guide for a course designed to prepare employees for statistical process control (SPC) training given at their workplace by refreshing math skills and building the concepts and vocabulary necessary to understand SPC in manufacturing environments. SPC-Prep 1 addresses the math skills necessary to perform…

  4. PREP advertisement features affect smokers’ beliefs regarding potential harm

    Science.gov (United States)

    Strasser, Andrew A; Tang, Kathy Z; Tuller, Michael D; Cappella, Joseph N

    2014-01-01

    Background The Institute of Medicine report on potential reduced exposure products (PREPs) recommends that advertising and labelling be regulated to prevent explicitly or implicitly false or misleading claims. Belief that a product is less harmful may increase use or prevent smoking cessation. Objective To determine the effect of altering advertisement features on smokers’ beliefs of the harm exposure from a PREP. Methods A Quest advertisement was digitally altered using computer software and presented to participants using web-based television recruitment contracted through a survey company. 500 current smokers completed demographic and smoking history questions, were randomised to view one of three advertisement conditions, then completed eight items assessing their beliefs of the harmfulness of the product. Advertisement conditions included the original, unaltered advertisement; a “red” condition where the cigarette packages were digitally altered to the colour red, implying increased harm potential; and a “no text” condition where all text was removed to reduce explicit product information. Polytomous logistic regression, using “incorrect,” “unsure” and “correct” as outcomes, and advertisement type and covariates as predictors, was used for analyses. Results Participants randomised to the “no text” advertisement were less likely to be incorrect in their beliefs that Quest cigarettes are lower in tar, less addictive, less likely to cause cancer, have fewer chemicals, healthier and make smoking safer. Conclusions Smokers can form false beliefs about the harmfulness of PREP products based on how the PREPs are marketed. Careful examination must be undertaken to provide empirical evidence to better formulate regulatory principles of PREP advertising. PMID:18768457

  5. Knowledge is Power! Increased Provider Knowledge Scores Regarding Pre-exposure Prophylaxis (PrEP) are Associated with Higher Rates of PrEP Prescription and Future Intent to Prescribe PrEP.

    Science.gov (United States)

    Blumenthal, Jill; Jain, Sonia; Krakower, Douglas; Sun, Xiaoying; Young, Jason; Mayer, Kenneth; Haubrich, Richard

    2015-05-01

    The FDA approval of emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP) in 2012 has raised questions about the delivery of PrEP in a real-world setting. iPad-based questionnaires were given to providers at conferences in California and New York to assess knowledge, experience and attitudes regarding PrEP in HIV and non-HIV providers. HIV provider status was defined either by self-identification or by having greater than 5 years of HIV care experience. Knowledge scores were the sum of correct answers from five PrEP knowledge questions. Univariate analyses used t-test to compare knowledge scores and Fisher's exact test for past or future PrEP prescription between HIV and non-HIV providers. Multivariable linear or logistic regression models were used to assess factors associated with the outcomes. Of 233 respondents, the mean age was 40 years, 59 % were White, 59 % were physicians and 52 % were HIV providers. In univariate analysis, mean PrEP knowledge scores (max 5) were significantly higher for HIV providers (2.8 versus 2.2; p 41 (mean 2.8 versus 2.3; p = 0.004), White race (2.7 versus 2.2; p = 0.026) and participants in the New York region (3.0 versus 2.3; p knowledge scores, all but age remained significant. Among 201 potential prescribers, the rate of prior PrEP prescription was higher among HIV providers than non-HIV providers (34 versus 9 %; p knowledge score, but the association with provider status was no longer significant in multivariable analysis that controlled for knowledge. Intent to prescribe PrEP in the future was high for all provider types (64 %) and was associated with knowledge scores in multivariable analysis. The most common concerns about PrEP (>40 % of providers) were drug toxicities, development of resistance and patient adherence to follow-up; 32 % identified risk compensation as a concern. HIV providers had significantly greater PrEP knowledge than non-HIV providers, but differences by provider type in past PrEP

  6. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    Science.gov (United States)

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  7. Bridging the Gap Between Scientists and Classrooms: Scientist Engagement in the Expedition Earth and Beyond Program

    Science.gov (United States)

    Graff, P. V.; Stefanov, W. L.; Willis, K. J.; Runco, S.

    2012-01-01

    Teachers in today s classrooms need to find creative ways to connect students with science, technology, engineering, mathematics (STEM) experts. These STEM experts can serve as role models and help students think about potential future STEM careers. They can also help reinforce academic knowledge and skills. The cost of transportation restricts teachers ability to take students on field trips exposing them to outside experts and unique learning environments. Additionally, arranging to bring in guest speakers to the classroom seems to happen infrequently, especially in schools in rural areas. The Expedition Earth and Beyond (EEAB) Program [1], facilitated by the Astromaterials Research and Exploration Science (ARES) Directorate Education Program at the NASA Johnson Space Center has created a way to enable teachers to connect their students with STEM experts virtually. These virtual connections not only help engage students with role models, but are also designed to help teachers address concepts and content standards they are required to teach. Through EEAB, scientists are able to actively engage with students across the nation in multiple ways. They can work with student teams as mentors, participate in virtual student team science presentations, or connect with students through Classroom Connection Distance Learning (DL) Events.

  8. The Summer Treatment Program Meets the South Side of Chicago: Bridging Science and Service in Urban After-School Programs.

    Science.gov (United States)

    Frazier, Stacy L; Chacko, Anil; Van Gessel, Christine; O'Boyle, Caroline; Pelham, William E

    2012-05-01

    BACKGROUND: This paper describes efforts to apply the principles and strategies of an empirically-supported treatment for children with disruptive behaviour problems to a park after-school program serving children in urban poverty. METHOD: Collaboration with staff proceeded in stages: (1) relationship building, needs assessment, and resource mapping; (2) intervention adaptation and implementation; and (3) implementation support, problem-solving, and sustainability. RESULTS: Four tools capitalised on inherent strengths of the parks, accommodated child and staff needs, and emerged as feasible and effective: Group Discussion, Good Behaviour Game, Peers as Leaders, and Good News Notes. CONCLUSIONS: Recreational settings offer opportunities for mental health promotion for children in urban poverty.

  9. Bridging the gap between empirical results, actual strategies, and developmental programs in soccer.

    Science.gov (United States)

    Figueiredo, António J; Gonçalves, Carlos E; Tessitore, Antonio

    2014-05-01

    Being one of the most prominent globalized sports, soccer played at club, national, and continental levels has a relevant societal role. At present, the specific competencies, interests, and languages of the different actors involved in the selection, development, and support of long-lasting careers of players might limit opportunities for potential talented players. Unless the cultural environment of soccer resolves the gaps between empirical results and actual soccer strategies, scientific discussion relating to the effectiveness of talent selection and development remains limited. This commentary is intended to highlight the need for developmental programs to prepare soccer personnel for a transdisciplinary dialogue, which could foster a future development of this sport. Finally, in considering the wide soccer-related employment opportunities at local, national, and international levels, the need for a clear qualification framework is crucial.

  10. Skin and surface lead contamination, hygiene programs, and work practices of bridge surface preparation and painting contractors.

    Science.gov (United States)

    Virji, M Abbas; Woskie, Susan R; Pepper, Lewis D

    2009-02-01

    A 2005 regulatory review of the lead in construction standard by the Occupational Safety and Health Administration (OSHA) noted that alternative pathways of exposure can be as significant as inhalation exposure and that noncompliance with the standard pertaining to hygiene facilities and practices was the second most commonly violated section of the standard. Noncompliance with provisions of the standard and unhealthy work and hygiene practices likely increase the likelihood of take-home lead via contaminated clothing, automobiles, and skin, thus contributing to elevated blood lead levels (BLL) among construction workers and their family members. We performed a cross-sectional study of bridge painters working for small contractors in Massachusetts to investigate causes of persistent elevated BLLs and to assess lead exposures. Thirteen work sites were evaluated for a 2-week period during which surface and skin wipe samples were collected and qualitative information was obtained on personal hygiene practices, decontamination and hand wash facilities, and respiratory protection programs. Results showed lead contamination on workers' skin, respirators, personal automobiles, and the decontamination unit, indicating a significant potential for take-home lead exposure. Overall, the geometric mean (GM) skin lead levels ranged from 373 microg on workers' faces at end of shift to 814 microg on hands at break time. The overall GM lead level inside respirators was 143 microg before work and 286 microg after work. Lead contamination was also present inside workers' personal vehicles as well as on surfaces inside the clean side of the decontamination unit. Review of the respiratory protection programs, work site decontamination and hand wash facilities, and personal hygiene practices indicated that these factors had significant impact on skin and surface contamination levels and identified significant opportunities for improving work site facilities and personal practices

  11. PrEP in Europe – expectations, opportunities and barriers

    Science.gov (United States)

    McCormack, Sheena Mary; Noseda, Veronica; Molina, Jean-Michel

    2016-01-01

    Introduction In contrast to the global trend showing a decline in new HIV infections, the number reported in the World Health Organization (WHO) region of Europe is increasing. Health systems are disparate, but even countries with free access to screening and treatment observe continuing high rates of new infections in key populations, notably men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is only available in France. This commentary describes the European epidemics and healthcare settings where PrEP could be delivered, how need might be estimated for MSM and the residual barriers to access. Discussion Health systems and government commitment to HIV prevention and care, both financial and political, differ considerably between the countries that make up Europe. A common feature is that funds for prevention are a small fraction of funds for care. Although care is generally good, access is limited in the middle-income countries of Eastern Europe and central Asia, and only 19% of people living with HIV received antiretroviral therapy in 2014. It is challenging to motivate governments or civil society to implement PrEP in the context of this unmet treatment need, which is driven by limited national health budgets and diminishing assistance from foreign aid. The high-income countries of Western Europe have hesitated to embrace PrEP for different reasons, initially due to key gaps in the evidence. Now that PrEP has been shown to be highly effective in European MSM in two randomized controlled trials, it is clear that the major barrier is the cost of the drug which is still on patent, although inadequate health systems and diminishing investment in civil society are also key challenges to overcome. Conclusions The momentum to implement PrEP in European countries is increasing and provides a welcome opportunity to expand and improve clinical services and civil society support focused on HIV and related infections including other sexually transmitted and

  12. Instructional and Organizational Effectiveness in Selected PREPS-Identified Value Added and PREPS-Identified Value Subtracted Elementary Schools in Mississippi

    Science.gov (United States)

    Henderson, Jimmy Dale

    2011-01-01

    This study examined the perceptions of principals, teachers, and support staff at 3 PREPS-identified value added and three PREPS-identified value subtracted elementary schools in Mississippi to determine if there were "effective schools" practices in the areas of instructional and organizational systems that were unique to either group. The…

  13. Teacher Development Program for ATP 2000. Project Report.

    Science.gov (United States)

    Sutphin, Dean; And Others

    Agri Tech Prep 2000 (ATP 2000) is a 4-year tech prep program linking high school and postsecondary curricula designed to prepare New York students for careers in agriculture or acceptance into a college program in agriculture. Because teacher development was designated an integral project component for fiscal year 1991-1992, a weeklong teacher…

  14. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Directory of Open Access Journals (Sweden)

    Iryna Zablotska

    2016-10-01

    Full Text Available Introduction: HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM and other key populations. Pre-exposure prophylaxis (PrEP is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion: Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions: Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes.

  15. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    Science.gov (United States)

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  16. Time-Dependent Effect of Chlorhexidine Surgical Prep

    Science.gov (United States)

    2011-10-15

    skin prep prior to venous puncture for blood cultures has resulted in a lower false-positive ratewhen compared to non-alcoholic povidoneeiodine.9...vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792e801. 9. Caldeira D, David C, Sampaio C. Skin antiseptics in venous puncture -site...load throughout the entire duration of the study. Regarding skin preparation prior to insertion of central venous pressure catheters, the current

  17. Meaning-making in the industrialized test prep classroom

    OpenAIRE

    2011-01-01

    Evidence for the efficacy of test-mimicking pedagogical practices anchored to "non-controversial topics" - what one researcher has referred to as the "McDonaldisation of English" and another, the "TOEFLizing of teaching" - is scarce. Though complex, the crux of the problem is 'negative washback' (the subordination of teaching to the dictates of the international proficiency assessment market) and 'test score pollution' (inflated prep-induced test results). This paper explores the issue in sev...

  18. Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

    Science.gov (United States)

    2015-10-01

    associated sepsis remains the principal lethal risk associated with platelet transfusion. Cold storage (4°C) is known to reduce post transfusion...and no residual radiation is detectable . *P-selectin samples will be prepped on end of storage day and batch tested. **Bacterial Culture sample...temperature controlled room until such time as they have no detectable residual radiation. This is generally about 3-4 months. At that point they are

  19. Research on Double-Dummy Bridge Playing Cards-Assisted Analysis Program%双明手桥牌打牌辅助分析程序研究

    Institute of Scientific and Technical Information of China (English)

    张志刚

    2015-01-01

    The key problem of design and implementation of the computer automatically playing the Bridge Game lies in the search space, and bridge game's search space is very large, and the traditional brute-force search method cannot easily solve it, and therefore proposes to solve double dummy bridge the depth-first alpha-beta search algorithm, uses C++ Builder programming language to implement the algo-rithm, the experiments show that the algorithm has in-depth study of value. It is a fundamental study for the intelligent computer bridge game.%桥牌计算机自动打牌程序的设计与实现关键在于问题空间的搜索,而桥牌的搜索空间非常大,而对于传统的蛮力搜索则面临较大困难,因此提出解决双明手桥牌的深度优先的alpha-beta搜索算法,并采用C++Builder程序设计语言加以实现. 实验证明,该算法具有深入研究的价值,同时为计算机桥牌游戏智能化研究打下理论基础.

  20. Pikes Peak Community College Deaf Prep Program Study Skills Curriculum.

    Science.gov (United States)

    George, Paula

    This study skills curriculum is designed to assist students who are deaf or hearing impaired to prepare for college life. It presents lesson plans and activities that address the following topics: (1) effective school tools; (2) effective school attitudes; (3) effective school behaviors; (4) time management and goal settings, including keeping…

  1. Allergic contact dermatitis to gamma-irradiated WEBCOL alcohol prep pads.

    Science.gov (United States)

    Firoz, Elnaz F; Turnbull, Rowena K; Loomis, Cynthia A; Brownell, Isaac

    2013-01-01

    We report a case of allergic contact dermatitis to WEBCOL(®) alcohol prep pads in a healthy 17-year-old girl who showed no reaction to the individual components of the prep pads upon provocative use testing. Although several case reports have described allergic contact dermatitis to isopropyl alcohol, there have been no reports of allergic contact dermatitis to alcohol prep pads sterilized with gamma irradiation, a common sterilization technique capable of producing volatile products in this type of alcohol prep pad.

  2. Myocardial Bridging

    Directory of Open Access Journals (Sweden)

    Shi-Min Yuan

    2016-02-01

    Full Text Available Abstract Myocardial bridging is rare. Myocardial bridges are most commonly localized in the middle segment of the left anterior descending coronary artery. The anatomic features of the bridges vary significantly. Alterations of the endothelial morphology and the vasoactive agents impact on the progression of atherosclerosis of myocardial bridging. Patients may present with chest pain, myocardial infarction, arrhythmia and even sudden death. Patients who respond poorly to the medical treatment with β-blockers warrant a surgical intervention. Myotomy is a preferred surgical procedure for the symptomatic patients. Coronary stent deployment has been in limited use due to the unsatisfactory long-term results.

  3. Scientific Growth and Identity Development during a Postbaccalaureate Program: Results from a Multisite Qualitative Study.

    Science.gov (United States)

    Remich, Robin; Naffziger-Hirsch, Michelle E; Gazley, J Lynn; McGee, Richard

    2016-01-01

    This report builds upon our previous study, which described five patterns of why college graduates join National Institutes of Health (NIH)-funded diversity-focused Postbaccalaureate Research Education Programs (PREP). A 2015 report from the NIH showed that a high fraction of PREP participants matriculate into PhD and MD/PhD programs. This current study reveals how participants change during PREP, the program elements that facilitate change, and how identity as a graduate student and future scientist develops. Data come from in-depth interviews done at the beginning and end of PREP with 48 individuals from seven PREP programs. Results reveal three domains of development: academics, research, and presentation of oneself; each domain contains a developmental continuum. Key attributes of PREP enabling development include opportunities to attend graduate-level classes and seminars; time to practice reading literature; extended lab time with one's own project; high and explicit expectations from mentors; and multiple opportunities to talk about science and improve communication skills. PREP enabled participants to develop their identities as graduate students and to anticipate being seen by others as highly prepared for PhD training. After PREP, 85% (n = 41) started the PhD or MD/PhD, making PREP an intervention approach with great potential to broaden participation in biomedical PhD programs.

  4. Application of the ThinPrep Imaging System in Urine Cytology A Prospective Study

    NARCIS (Netherlands)

    van Hemel, Bettien M.; Haarsma, Jolanda G.; Ruitenbeek, Teus; Groen, Henk; Suurmeijer, Albert J. H.

    2013-01-01

    BACKGROUND In this prospective study, for the first time, the authors compared the accuracy of reading urine specimens using the ThinPrep Imager System (TIS) with the accuracy of conventional screening for the detection of abnormal urine cells. METHODS ThinPrep slides were made from 1455 urine speci

  5. Charter Schools as Nation Builders: Democracy Prep and Civic Education. Policy Brief 4

    Science.gov (United States)

    Lautzenheiser, Daniel; Kelly, Andrew P.

    2013-01-01

    This policy brief is the first in a series of in-depth case studies exploring how top-performing charter schools have incorporated civic learning in their school curriculum and school culture. This paper introduces Democracy Prep, a network of seven public charter schools with a civic mission at its core. Democracy Prep's founder and…

  6. Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.

    Directory of Open Access Journals (Sweden)

    Kentaro Yoshioka

    Full Text Available Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused late embryonic lethality associated with defective hematopoiesis and angiogenesis. In the present study, we generated hematopoietic- and endothelial cell-specific Prep1-deficient mice and demonstrated that expression of Prep1 in the hematopoietic cell compartment is not essential for either embryonic or adult hematopoiesis, although its absence causes significant hematopoietic abnormalities in the adult bone marrow. Loss of Prep1 promotes cell cycling of hematopoietic stem/progenitor cells (HSPC, leading to the expansion of the HSPC pool. Prep1 deficiency also results in the accumulation of lineage-committed progenitors, increased monocyte/macrophage differentiation and arrested erythroid maturation. Maturation of T cells and B cells is also perturbed in Prep-deficient mice. These findings provide novel insight into the pleiotropic roles of Prep1 in adult hematopoiesis that were unrecognized in previous studies using germline Prep1 hypomorphic mice.

  7. Bridging science to service: using Rehabilitation Research and Training Center program to ensure that research-based knowledge makes a difference.

    Science.gov (United States)

    Farkas, Marianne; Anthony, William A

    2007-01-01

    The challenge of bridging science to service is increasingly visible in the healthcare field, with emphasis on the influence of evidence-based knowledge on both policy and practice. Since its inception more than 40 years ago, the Rehabilitation Research and Training Center (RRTC) program has provided grants for both research and training activities designed to ensure that research knowledge is translated into practice. The RRTC program is unique in that its mission and funding have always required that both time and money be invested in the translation and dissemination of research-generated knowledge to users in the field, i.e., decision makers and practitioners. Boston University's Center for Psychiatric Rehabilitation has been an RRTC for more than 25 years and provides an example of the effect of the RRTC program in bridging science to service. The Center's mission as an RRTC has been to develop and transfer research knowledge to decision makers and practitioners who can then inform change and promote progress in mental health disability policy and practice. This article reviews five basic dissemination and utilization principles for overcoming the most common barriers to effective dissemination of evidence-based knowledge and provides examples of the Center's activities related to each principle. In addition, a knowledge-transfer framework developed by the Center to organize dissemination and utilization efforts is described.

  8. Bridge Management Systems

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper bridge management systems are discussed with special emphasis on management systems for reinforced concrete bridges. Management systems for prestressed concrete bridges, steel bridges, or composite bridges can be developed in a similar way....

  9. Mapping the Beat: A History and Geography through Music Curriculum at the University of California San Diego, ArtsBridge America Program - United States History from 1776-1865 for 5th Grade

    OpenAIRE

    Scholl, Jennifer Coordinator; Baker, James; Boyer, William; Eidsheim, Nina

    2002-01-01

    In 2002, the University of California San Diego ArtsBridge America program initiated a project, funded by the National Geographic Society Education Foundation, that was designed to address the lack of standards-based geography content and culture-based arts instruction within San Diego elementary schools. Representatives from host ArtsBridge institutions identified the following factors contributing to this deficiency: • a perceived lack of arts and geography competence amongst elementary ...

  10. National Bridge Inventory (NBI) Bridges

    Data.gov (United States)

    Department of Homeland Security — The NBI is a collection of information (database) describing the more than 600,000 of the Nation's bridges located on public roads, including Interstate Highways,...

  11. Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.

    Directory of Open Access Journals (Sweden)

    Elisa Bernardi

    Full Text Available Prep1 is a developmentally essential TALE class homeodomain transcription factor. In zebrafish and mouse, Prep1 is already ubiquitously expressed at the earliest stages of development, with important tissue-specific peculiarities. The Prep1 gene in mouse is developmentally essential and has haploinsufficient tumor suppressor activity [1]. We have determined the human Prep1 transcription start site (TSS by primer extension analysis and identified, within 20 bp, the transcription start region (TSR of the zebrafish Prep1.1 promoter. The functions of the zebrafish 5' upstream sequences were analyzed both by transient transfections in Hela Cells and by injection in zebrafish embryos. This analysis revealed a complex promoter with regulatory sequences extending up to -1.8, possibly -5.0 Kb, responsible for tissue specific expression. Moreover, the first intron contains a conserved tissue-specific enhancer both in zebrafish and in human cells. Finally, a two nucleotides mutation of an EGR-1 site, conserved in all species including human and zebrafish and located at a short distance from the TSS, destroyed the promoter activity of the -5.0 Kb promoter. A transgenic fish expressing GFP under the -1.8 Kb zebrafish promoter/enhancer co-expressed GFP and endogenous Prep1.1 during embryonic development. In the adult fish, GFP was expressed in hematopoietic regions like the kidney, in agreement with the essential function of Prep1 in mouse hematopoiesis. Sequence comparison showed conservation from man to fish of the sequences around the TSS, within the first intron enhancer. Moreover, about 40% of the sequences spread throughout the 5 Kbof the zebrafish promoter are concentrated in the -3 to -5 Kb of the human upstream region.

  12. Social, structural, behavioral and clinical factors influencing retention in Pre-Exposure Prophylaxis (PrEP) care in Mississippi

    Science.gov (United States)

    Arnold, Trisha; Brinkley-Rubinstein, Lauren; Chan, Philip A.; Perez-Brumer, Amaya; Bologna, Estefany S.; Beauchamps, Laura; Johnson, Kendra; Mena, Leandro; Nunn, Amy

    2017-01-01

    Pre-exposure prophylaxis (PrEP) is a biomedical intervention that can reduce rates of HIV transmission when taken once daily by HIV-negative individuals. Little is understood about PrEP uptake and retention in care among the populations most heavily impacted by the HIV epidemic, particularly among young men who have sex with men (YMSM) in the Deep South. Therefore, this study explored the structural, social, behavioral, and clinical factors that affect PrEP use and retention in care among YMSM in Jackson, Mississippi. Thirty MSM who were prescribed PrEP at an outpatient primary care clinic were interviewed and included 23 men who had been retained in PrEP care and seven who had not been retained. The mean age of participants was 26.6 years. Most (23) participants were African American. Major factors affecting PrEP use and retention in PrEP care included 1) structural factors such as cost and access to financial assistance for medications and clinical services; 2) social factors such as stigma and relationship status; 3) behavioral factors including sexual risk behaviors; and 4) clinical factors such as perceived and actual side effects. Many participants also discussed the positive spillover effects of PrEP use and reported that PrEP had a positive impact on their health. Four of the seven individuals who had not been retained re-enrolled in PrEP care after completing their interviews, suggesting that case management and ongoing outreach can enhance retention in PrEP care. Interventions to enhance retention in PrEP care among MSM in the Deep South will be most effective if they address the complex structural, social, clinical, and behavioral factors that influence PrEP uptake and retention in PrEP care. PMID:28222118

  13. Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

    Science.gov (United States)

    Oriente, Francesco; Fernandez Diaz, Luis Cesar; Miele, Claudia; Iovino, Salvatore; Mori, Silvia; Diaz, Victor Manuel; Troncone, Giancarlo; Cassese, Angela; Formisano, Pietro; Blasi, Francesco; Beguinot, Francesco

    2008-09-01

    We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by skeletal muscle. This muscle phenotype does not depend on reduced expression of the known Prep1 transcription partner, Pbx1. Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160. Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle. Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1. In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype. Finally, we show that Prep1 controls the stability of the p160 protein. We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.

  14. Efficient endotoxin removal with a new sanitizable affinity column: Affi-Prep Polymyxin.

    Science.gov (United States)

    Talmadge, K W; Siebert, C J

    1989-08-04

    A new affinity column packing for removal of endotoxins has been prepared by coupling USP drug-quality polymyxin B to Affi-Prep, a novel synthetic macroporous polymer. Affi-Prep Polymyxin binds endotoxins from a number of different strains of gram-negative bacteria. Endotoxin binding is not significantly affected by 10 mg/ml of bovine serum albumin or human immunoglobulin G, by 1 mg/ml sodium dodecyl sulphate, or by 1 mg/ml deoxycholate. Affi-Prep Polymyxin is stable to treatment with 1.0 M sodium hydroxide, an important property for sanitizing the resin. The resin shows a high ligand stability, since no leakage of polymyxin B from the packing could be detected. Affi-Prep Polymyxin exhibited the highest endotoxin binding efficiency when compared with several commercial agarose affinity packings.

  15. Preliminary investigation of the advertising and availability of PREPs, the new "safe" tobacco products.

    Science.gov (United States)

    Hickman, Norval; Klonoff, Elizabeth A; Landrine, Hope; Kashima, Kennon; Parekh, Bina; Fernandez, Senaida; Thomas, Kamala; Brouillard, Catherine; Zolezzi, Michele; Jensen, Jennifer; Weslowski, Zorahna

    2004-08-01

    The tobacco industry recently introduced a new set of "safe" cigarettes and nicotine delivery devices that purportedly entail reduced tobacco-related disease risk due to their lower level of some carcinogens and toxins. Little is know about the biological impact of these potential reduced exposure products (PREPs) and nothing is known about their advertising and availability. Hence, two pilot studies were conducted to examine the latter issues for the first time. In Study 1, we examined tobacco ads in 10 popular magazines 1998--2002 and found that only 1% of ads were for PREPs. In Study 2, we attempted to purchase PREPs in a random sample of 113 small stores and found that only 4.4% sold any PREP. These preliminary findings tentatively suggest that the industry might not yet be heavily invested in products that have the potential to increase tobacco use by decreasing its perceived harm. Studies with larger samples are recommended.

  16. Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.

    Science.gov (United States)

    Mathiasen, Lisa; Bruckmann, Chiara; Pasqualato, Sebastiano; Blasi, Francesco

    2015-01-01

    Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high instability and insufficient purity, in particular for structural studies. We cloned the cDNA of both proteins into a dicistronic vector containing an N-terminal glutathione S-transferase (GST) tag and co-expressed and co-purified a stable PBX1:PREP1 complex. For structural studies, we produced two C-terminally truncated complexes that retain their ability to bind DNA and are more stable than the full-length proteins through various purification steps. Here we report the production of large amounts of soluble and pure recombinant human PBX1:PREP1 complex in an active form capable of binding DNA.

  17. The Use of REACT Strategy for the Incorporation of the Context of Physics into the Teaching English to the Physics English Prep Students

    Directory of Open Access Journals (Sweden)

    ALİ SÜKRÜ ÖZBAY

    2015-12-01

    Full Text Available The Use of REACT Strategy for the Incorporation of the Context of Physics into the Teaching English to the Physics English Prep Students Abstract  The present study explores department of Physics prep students’ (department of Physics students attending English preparatory program relative performance in English grammar by the use of contextual learning materials in the actual classroom instruction based on the contextual learning theory. Thus, the purpose of this study is to investigate the effect of teaching grammar in physics context for the physics prep students to increase their interests in learning English. Another primary goal of the study is to evaluate the teaching activities which are developed in accordance with the REACT (relating, experiencing, applying, cooperating and transferring strategy in context based approach. The study was with 25 students of Physics at an English prep-school in Turkey. With the aim of determining the effect of contextual teaching materials, sample lessons based on the contextual knowledge and the target grammar points were made. Following the lessons, a structured interview was delivered to the five of the participants. One result is that the incorporation of REACT strategy into the teaching of English to the Physics students proved to be useful for the learners who took part in the study, adding that relating, experiencing, applying, cooperating and transferring the knowledge respectively helped them use and retain the knowledge far more than the traditional classroom teaching methods in grammar teaching. Another specific outcome of the overall findings is that students were able to establish connections between what they learn and how that knowledge can be utilized in physics, which, in turn, has increased their motivation to a higher level.

  18. Bridged graphite oxide materials

    Science.gov (United States)

    Herrera-Alonso, Margarita (Inventor); McAllister, Michael J. (Inventor); Aksay, Ilhan A. (Inventor); Prud'homme, Robert K. (Inventor)

    2010-01-01

    Bridged graphite oxide material comprising graphite sheets bridged by at least one diamine bridging group. The bridged graphite oxide material may be incorporated in polymer composites or used in adsorption media.

  19. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Directory of Open Access Journals (Sweden)

    Daniel A Felix

    2010-04-01

    Full Text Available Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is

  20. The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration.

    Science.gov (United States)

    Felix, Daniel A; Aboobaker, A Aziz

    2010-04-22

    Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi) animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation) to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is required for

  1. Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.

    Science.gov (United States)

    Longobardi, E; Penkov, D; Mateos, D; De Florian, G; Torres, M; Blasi, Francesco

    2014-01-01

    TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction surfaces. Members of the three sets of protein form dimers in which the common partner is PBX but they can also directly interact with other proteins forming higher-order complexes, in particular HOX. Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed. These studies have generated a few general rules that can be applied to all members of the three gene families. PREP and MEIS recognize slightly different consensus sequences: PREP prefers to bind to promoters and to have PBX as a DNA-binding partner; MEIS prefers HOX as partner, and both PREP and MEIS drive PBX to their own binding sites. This outlines the clear individuality of the PREP and MEIS proteins, the former mostly devoted to basic cellular functions, the latter more to developmental functions.

  2. Preferences for HIV pre-exposure prophylaxis (PrEP) information among men-who-have-sex-with-men (MSM) at community outreach settings

    Science.gov (United States)

    Merchant, Roland C.; Corner, David; Garza, Eduardo; Guan, Wentao; Mayer, Kenneth H.; Brown, Larry; Chan, Philip A

    2016-01-01

    Community outreach efforts to increase HIV pre-exposure prophylaxis (PrEP) utilization by at risk men-who-have-sex-with-men (MSM) first need to elucidate preferences for learning about PrEP and linking to PrEP resources. In this pilot study, we observed that among MSM recruited through community outreach, HIV sexual risk-taking was significant, yet self-perceived PrEP knowledge was low and interest in learning more about PrEP was moderate. Most preferred learning about PrEP and being provided local PrEP clinic information through electronic media. However, receipt of PrEP information alone did not appear to motivate these men into presenting to a local clinic for PrEP evaluation. PMID:27076865

  3. Moving evidence-based drug abuse prevention programs from basic science to practice: "bridging the efficacy-effectiveness interface".

    Science.gov (United States)

    August, Gerald J; Winters, Ken C; Realmuto, George M; Tarter, Ralph; Perry, Cheryl; Hektner, Joel M

    2004-01-01

    This article examines the challenges faced by developers of youth drug abuse prevention programs in transporting scientifically proven or evidence-based programs into natural community practice systems. Models for research on the transfer of prevention technology are described with specific emphasis given to the relationship between efficacy and effectiveness studies. Barriers that impede the successful integration of efficacy methods within effectiveness studies (e.g., client factors, practitioner factors, intervention structure characteristics, and environmental and organizational factors) are discussed. We present a modified model for program development and evaluation that includes a new type of research design, the hybrid efficacy-effectiveness study that addresses program transportability. The utility of the hybrid study is illustrated in the evaluation of the Early Risers "Skills for Success" prevention program.

  4. Did we get our money's worth? Bridging economic and behavioral measures of program success in adolescent drug prevention.

    Science.gov (United States)

    Griffith, Kevin N; Scheier, Lawrence M

    2013-11-08

    The recent U.S. Congressional mandate for creating drug-free learning environments in elementary and secondary schools stipulates that education reform rely on accountability, parental and community involvement, local decision making, and use of evidence-based drug prevention programs. By necessity, this charge has been paralleled by increased interest in demonstrating that drug prevention programs net tangible benefits to society. One pressing concern is precisely how to integrate traditional scientific methods of program evaluation with economic measures of "cost efficiency". The languages and methods of each respective discipline don't necessarily converge on how to establish the true benefits of drug prevention. This article serves as a primer for conducting economic analyses of school-based drug prevention programs. The article provides the reader with a foundation in the relevant principles, methodologies, and benefits related to conducting economic analysis. Discussion revolves around how economists value the potential costs and benefits, both financial and personal, from implementing school-based drug prevention programs targeting youth. Application of heterogeneous costing methods coupled with widely divergent program evaluation findings influences the feasibility of these techniques and may hinder utilization of these practices. Determination of cost-efficiency should undoubtedly become one of several markers of program success and contribute to the ongoing debate over health policy.

  5. Did We Get Our Money’s Worth? Bridging Economic and Behavioral Measures of Program Success in Adolescent Drug Prevention

    Directory of Open Access Journals (Sweden)

    Lawrence M. Scheier

    2013-11-01

    Full Text Available The recent U.S. Congressional mandate for creating drug-free learning environments in elementary and secondary schools stipulates that education reform rely on accountability, parental and community involvement, local decision making, and use of evidence-based drug prevention programs. By necessity, this charge has been paralleled by increased interest in demonstrating that drug prevention programs net tangible benefits to society. One pressing concern is precisely how to integrate traditional scientific methods of program evaluation with economic measures of “cost efficiency”. The languages and methods of each respective discipline don’t necessarily converge on how to establish the true benefits of drug prevention. This article serves as a primer for conducting economic analyses of school-based drug prevention programs. The article provides the reader with a foundation in the relevant principles, methodologies, and benefits related to conducting economic analysis. Discussion revolves around how economists value the potential costs and benefits, both financial and personal, from implementing school-based drug prevention programs targeting youth. Application of heterogeneous costing methods coupled with widely divergent program evaluation findings influences the feasibility of these techniques and may hinder utilization of these practices. Determination of cost-efficiency should undoubtedly become one of several markers of program success and contribute to the ongoing debate over health policy.

  6. STEM Beyond The Classroom: Creating Authentic Outreach Programs That Build Bridges Between The Classroom And Real World Challenges

    Science.gov (United States)

    Ibarra, D. L.; Forder, S. E.; Pritchard, M.

    2014-12-01

    The ISF Academy was founded by Charles Kao, a Nobel Prize laureate. In 2011, the Shuyuan programs were established at The ISF Academy to operate both as a "school within a school" and as a "school outside the classroom." The Shuyuan programs work together with the IBO Science and Technology subject areas to develop comprehensive and challenging opportunities that address the 14 Grand Engineering Challenges. The goal is to establish co-curricular programs that go beyond the taught curriculum and support STEM curricula. Several programs outside of the classroom include an onsite robotics researcher, underwater and land based robotics programs, field trips, whole school food waste composting and the implementation of an energy tracking system. Relationships with several local universities allow students to work closely with professors in research settings and, annually, a leading researcher gives a keynote speech to our students. Other signature Shuyuan programs have developed international strategic relationships with the NRI at Cambridge University, where students spend several weeks studying science and civilization in China using primary source materials. Additionally, Shuyuan has supported extension opportunities for classroom teachers with institutional partnerships that include the British Council, governmental organizations, local universities, corporations, and NGOs. In conclusion, the overall goal of the Shuyuan Programs is to provide experiential learning opportunities that challenge conventional curriculum design in a manner that is supportive and innovative!

  7. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...... in the Media”, “Audience Interactivity and Participation”, “The Role of Media and ICT Use for Evolving Social Relationships” and “Audience Transformations and Social Integration”. Building Bridges is the result of an ongoing dialogue between the Action and non-academic stakeholders in the field of audience...... Belgrade), Leo Pekkala (Finnish Centre for Media Education and Audiovisual Media/MEKU), Julie Uldam (Network on Civic Engagement and Social Innovation) and Gabriella Velics (Community Media Forum Europe)....

  8. Mathematical bridges

    CERN Document Server

    Andreescu, Titu; Tetiva, Marian

    2017-01-01

    Building bridges between classical results and contemporary nonstandard problems, Mathematical Bridges embraces important topics in analysis and algebra from a problem-solving perspective. Blending old and new techniques, tactics and strategies used in solving challenging mathematical problems, readers will discover numerous genuine mathematical gems throughout that will heighten their appreciation of the inherent beauty of mathematics. Most of the problems are original to the authors and are intertwined in a well-motivated exposition driven by representative examples. The book is structured to assist the reader in formulating and proving conjectures, as well as devising solutions to important mathematical problems by making connections between various concepts and ideas from different areas of mathematics. Instructors and educators teaching problem-solving courses or organizing mathematics clubs, as well as motivated mathematics students from high school juniors to college seniors, will find Mathematical Bri...

  9. Role of the pharmacist in pre-exposure chemoprophylaxis (PrEP) therapy for HIV prevention.

    Science.gov (United States)

    Clauson, Kevin A; Polen, Hyla H; Joseph, Shine A; Zapantis, Antonia

    2009-01-01

    With a global estimate of 2.5 million new infections of HIV occurring yearly, discovering novel methods to help stem the spread of the virus is critical. The use of antiretroviral chemoprophylaxis for preventing HIV after accidental or occupational exposure and in maternal to fetal transmission has become a widely accepted method to combat HIV. Based on this success, pre-exposure chemoprophylaxis (PrEP) is being explored in at-risk patient populations such as injecting drug users, female sex workers and men who have sex with men. This off-label and unmonitored use has created a need for education and intervention by pharmacists and other healthcare professionals. Pharmacists should educate themselves on PrEP and be prepared to counsel patients about their means of obtaining it (e.g. borrowing or sharing medications and ordering from disreputable Internet pharmacies). They should also be proactive about medication therapy management in these patients due to clinically important drug interactions with PrEP medications. Only one trial exploring the safety and efficacy of tenofovir as PrEP has been completed thus far. However, five ongoing trials are in various stages and two additional studies are scheduled for the near future. Unfortunately, studies in this arena have met with many challenges that have threatened to derail progress. Ethical controversy surrounding post-trial care of participants who seroconvert during studies, as well as concerns over emerging viral resistance and logistical site problems, have already halted several PrEP trials. Information about these early trials has already filtered down to affected individuals who are experimenting with this unproven therapy as an "evening before pill". The potential for PrEP is promising; however, more extensive trials are necessary to establish its safety and efficacy. Pharmacists are well-positioned to play a key role in helping patients make choices about PrEP, managing their therapy, and developing policy

  10. Bridging the gap: an innovative dementia learning program for healthcare assistants in hospital wards using facilitator-led discussions.

    Science.gov (United States)

    Chapman, Alan; Law, Shirley

    2009-04-01

    Nursing a person with dementia in a ward setting can be stressful and a challenge for staff and patients alike. Healthcare assistants are identified as requiring a specific training program. They form part of the front-line workforce and yet have the least access to training but often most contact with patients. The program in this study focused on person-centered care and used six self-study workbooks. Experienced registered nurses are trained to be facilitators of 12 group discussions in the ward setting. The training program viewed the facilitator as playing a key role in empowering the healthcare assistant but also in promoting reflective practice. The outcomes to date have been positive and showed a development in confidence and competence of the healthcare assistants involved.

  11. Teaching English Language Arts to Francophone Program Students, Grades 3 to 9: Bridging the Francais and English Language Arts (ELA) Programs of Study.

    Science.gov (United States)

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This document is the first in a 3-part collection titled "Teaching English Language Arts (ELA) to Francophone Program Students" to be used primarily by ELA teachers in their efforts to ensure that francophone program students build on their established French language skills when learning English. It is designed to show that a strong correlation…

  12. 某钢箱人行天桥动力特性及广告牌加设方案分析%The Dynamic Characteristics of a Steel - box Pedestrian Bridge and Program Analysis of Pedestrian Bridge Installed with Billboard

    Institute of Scientific and Technical Information of China (English)

    杨洋; 丁瑞瑞

    2015-01-01

    As a result of own merit of high strength and light weight, the steel structure, matched the development of cities, obtained the widespread application in recent ten years. However, the pedestrian bridges' burthen has been gradually in-creasing because of rapid development of urban construction and steady expanding of population, together with people's aesthetic requirements, therefore, it is urgent to analyse the reliability of the existing steel pedestrian bridges. In view of the existing situ-ation, with the pedestrian bridge of jinxin plaza in FuGu county, Shaanxi, for example, to ensure the safety of installing bill-boards on the pedestrian bridge, a site loading test has been done, and briefly analyse the static and dynamic characteristics of the pedestrian bridge. Through the analysis of the natural fre-quencies and the displacement time history of the pedestrian bridge, pointed out the existing problems about the billboard on the bridge, and proposed corresponding measures about reinfor-cing and reforming the billboards. It can serve as references for the design, construction and maintenance of the similar pedestri-an bridge structure.%由于钢结构强度高、自重轻的优点,并且能适应城市的发展需要,在近十多年来得到了很大应用。然而,随着城市建设的大力发展和人口的日益增长,加之人们对美学的要求,钢结构人行天桥的负荷程度日益增加,因此,对现有钢结构人行天桥进行可靠性分析是十分重要的。本文针对这一现状,以陕西省府谷县金信广场人行天桥为例,为使该人行天桥安全的加装广告牌,对其进行了现场荷载试验,简要分析了人行天桥静力,动力特性,通过分析该人行天桥的自振频率和位移时程,指出了广告牌在该桥中存在的问题,并提出了相应广告牌加固改造措施,可为类似结构的人行天桥设计、施工及维修养护提供参考。

  13. Rethinking HIV prevention to prepare for oral PrEP implementation for young African women

    Directory of Open Access Journals (Sweden)

    Connie L Celum

    2015-07-01

    Full Text Available Introduction: HIV incidence remains high among young women in sub-Saharan Africa in spite of scale-up of HIV testing, behavioural interventions, antiretroviral treatment and medical male circumcision. There is a critical need to critique past approaches and learn about the most effective implementation of evidence-based HIV prevention strategies, particularly emerging interventions such as pre-exposure prophylaxis (PrEP. Discussion: Women in sub-Saharan Africa are at increased risk of HIV during adolescence and into their 20s, in part due to contextual factors including gender norms and relationship dynamics, and limited access to reproductive and sexual health services. We reviewed behavioural, behavioural economic and biomedical approaches to HIV prevention for young African women, with a particular focus on the barriers, opportunities and implications for implementing PrEP in this group. Behavioural interventions have had limited impact in part due to not effectively addressing the context, broader sexual norms and expectations, and structural factors that increase risk and vulnerability. Of biomedical HIV prevention strategies that have been tested, daily oral PrEP has the greatest evidence for protection, although adherence was low in two placebo-controlled trials in young African women. Given high efficacy and effectiveness in other populations, demonstration projects of open-label PrEP in young African women are needed to determine the most effective delivery models and whether women at substantial risk are motivated and able to use oral PrEP with sufficient adherence to achieve HIV prevention benefits. Conclusions: Social marketing, adherence support and behavioural economic interventions should be evaluated as part of PrEP demonstration projects among young African women in terms of their effectiveness in increasing demand and optimizing uptake and effective use of PrEP. Lessons learned through evaluations of implementation strategies

  14. PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study.

    Science.gov (United States)

    Cremin, Ide; McKinnon, Lyle; Kimani, Joshua; Cherutich, Peter; Gakii, Gloria; Muriuki, Festus; Kripke, Katharine; Hecht, Robert; Kiragu, Michael; Smith, Jennifer; Hinsley, Wes; Gelmon, Lawrence; Hallett, Timothy B

    2017-05-01

    The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget and to identify the circumstances in which pre-exposure prophylaxis (PrEP) could be used in Nairobi, Kenya. A mathematical model was developed to represent HIV transmission in specific key populations (female sex workers, male sex workers, and men who have sex with men [MSM]) and among the wider population of Nairobi. The scale-up of existing interventions (condom promotion, antiretroviral therapy, and male circumcision) for key populations and the wider population as have occurred in Nairobi is represented. The model includes a detailed representation of a PrEP intervention and is calibrated to prevalence and incidence estimates specific to key populations and the wider population. In the context of a declining epidemic overall but with a large sub-epidemic in MSM and male sex workers, an optimal prevention portfolio for Nairobi should focus on condom promotion for male sex workers and MSM in particular, followed by improved antiretroviral therapy retention, earlier antiretroviral therapy, and male circumcision as the budget allows. PrEP for male sex workers could enter an optimal portfolio at similar levels of spending to when earlier antiretroviral therapy is included; however, PrEP for MSM and female sex workers would be included only at much higher budgets. If PrEP for male sex workers cost as much as US$500, average annual spending on the interventions modelled would need to be less than $3·27 million for PrEP for male sex workers to be excluded from an optimal portfolio. Estimated costs per infection averted when providing PrEP to all female sex workers regardless of their risk of infection, and to high-risk female sex workers only, are $65 160 (95% credible interval [CrI] $43 520-$90 250) and $10 920 (95% CrI $4700

  15. Building bridges: qualitative assessment of a clinical faculty exchange between a naturopathic and an allopathic medical training program.

    Science.gov (United States)

    McCarty, Rachelle L; Fenn, Robin; Gaster, Barak; Weber, Wendy; Guiltinan, Jane

    2011-01-01

    What are the perceived benefits of a clinical exchange experience designed as part of a program to promote acceptance and use of evidence-based medicine (EBM) in naturopathic clinical practice? Nine faculty members participated in a focus group (n = 6) or a structured interview (n = 3) to assess experience in the program. Investigators independently analyzed transcribed notes for common experience themes. ANALYSIS AND INTERPRETATION: Six major themes emerged: integrating EBM into naturopathic clinical teaching, strengthening of professional relationships, exposure to clinical experiences outside the usual naturopathic scope, reaffirmation of naturopathic training and profession, observation of clinical and administrative resources and practices, and recommendations for future clinical exchanges. A clinical exchange experience was viewed as a favorable way to promote EBM appreciation within the complementary and alternative medicine educational community and to foster improved clinical experiences for faculty and their students and patients. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Surveillance indicators for potential reduced exposure products (PREPs: developing survey items to measure awareness

    Directory of Open Access Journals (Sweden)

    McNeill Ann

    2009-10-01

    Full Text Available Abstract Background Over the past decade, tobacco companies have introduced cigarettes and smokeless tobacco products (known as Potential Reduced Exposure Products, PREPs with purportedly lower levels of some toxins than conventional cigarettes and smokeless products. It is essential that public health agencies monitor awareness, interest, use, and perceptions of these products so that their impact on population health can be detected at the earliest stages. Methods This paper reviews and critiques existing strategies for measuring awareness of PREPs from 16 published and unpublished studies. From these measures, we developed new surveillance items and subjected them to two rounds of cognitive testing, a common and accepted method for evaluating questionnaire wording. Results Our review suggests that high levels of awareness of PREPs reported in some studies are likely to be inaccurate. Two likely sources of inaccuracy in awareness measures were identified: 1 the tendency of respondents to misclassify "no additive" and "natural" cigarettes as PREPs and 2 the tendency of respondents to mistakenly report awareness as a result of confusion between PREPs brands and similarly named familiar products, for example, Eclipse chewing gum and Accord automobiles. Conclusion After evaluating new measures with cognitive interviews, we conclude that as of winter 2006, awareness of reduced exposure products among U.S. smokers was likely to be between 1% and 8%, with the higher estimates for some products occurring in test markets. Recommended measurement strategies for future surveys are presented.

  17. Cost-effectiveness of pre-exposure prophylaxis targeted to high-risk serodiscordant couples as a bridge to sustained ART use in Kampala, Uganda

    Directory of Open Access Journals (Sweden)

    Roger Ying

    2015-07-01

    Full Text Available Introduction: Despite scale-up of antiretroviral therapy (ART for treating HIV-positive persons, HIV incidence remains elevated among those at high risk such as persons in serodiscordant partnerships. Antiretrovirals taken by HIV-negative persons as pre-exposure prophylaxis (PrEP has the potential to avert infections in individuals in serodiscordant partnerships. Evaluating the cost-effectiveness of implementing time-limited PrEP as a short-term bridge during the first six months of ART for the HIV-positive partner to prevent HIV transmission compared to increasing ART coverage is crucial to informing policy-makers considering PrEP implementation. Methods: To estimate the real world delivery costs of PrEP, we conducted micro-costing and time and motion analyses in an open-label prospective study of PrEP and ART delivery targeted to high-risk serodiscordant couples in Uganda (the Partners Demonstration Project. The cost (in USD, in 2012 of PrEP and ART for serodiscordant couples was assessed, with and without research components, in the study setting. Using Ministry of Health costs, the cost of PrEP and ART provision within a government programme was estimated, as was the cost of providing PrEP in addition to ART. We parameterized an HIV transmission model to estimate the health and economic impacts of 1 PrEP and ART targeted to high-risk serodiscordant couples in the context of current ART use and 2 increasing ART coverage to 55% of HIV-positive persons with CD4 ≤500 cells/µL without PrEP. The incremental cost-effectiveness ratios (ICERs per HIV infection and disability-adjusted life year (DALY averted were calculated over 10 years. Results: The annual cost of PrEP and ART delivery for serodiscordant couples was $1058 per couple in the study setting and $453 in the government setting. The portion of the programme cost due to PrEP was $408 and $92 per couple per year in the study and government settings, respectively. Over 10 years, a

  18. PREP-kurser for soldater, veteraner og deres partnere - en procesevaluering

    DEFF Research Database (Denmark)

    Pollmann, Jeanette Bonde; Hartmann-Madsen, Anne; Vedtofte, Mia Sadowa

    2016-01-01

    Formålet med procesevalueringen er at evaluere, hvordan implementeringen af initiativet PREP-kurser for soldater, veteraner og deres partnere er forløbet. PREP-kurserne tilbydes gratis i en projektperiode fra 2015-2017 i anerkendelsen af at udsendelser kan påvirke parforholdet og kommunikationen...... at evalueringsprocessen er hensigtsmæssig. Det kan ud fra procesevalueringen konkluderes at PREP for soldater, veteraner og deres partnere er blevet implementeret med succes, men at det bør sikres at rapportens anbefalinger implementeres. Vi anbefaler på baggrund af ovenstående at dette initiativ gøres til et permanent...... tilbud for soldater, veteraner og deres pårørende....

  19. Influence of Processing Parameters on Granularity Distribution of Superalloy Powders during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming CHEN; Benfu HU; Yiwen ZHANG; Huiying LI; Quanmao YU

    2003-01-01

    In order to investigate the influence of processing parameters on the granularity distribution of superalloy powders during the atomization of plasma rotating electrode processing (PREP), in this paper FGH95 superalloy powders is prepared under different processing conditions by PREP and the influence of PREP processing parameters on the granularity distribution of FGH95 superalloy powders is discussed based on fractal geometry theory. The results show that with the increase of rotating velocity of the self-consuming electrode, the fractal dimension of the granularity distribution increases linearly, which results in the increase of the proportion of smaller powders. The change of interval between plasma gun and the self-consuming electrode has a little effect on the granularity distribution, also the fractal dimension of the granularity distribution changed a little correspondingly.

  20. Potential Interventions to Support Adherence to HIV Preexposure Prophylaxis (PrEP): A Systematic Review

    Science.gov (United States)

    Marcus, Julia L.; Buisker, Timothy; Horvath, Tara; Amico, K. Rivet; Fuchs, Jonathan D.; Buchbinder, Susan P.; Grant, Robert M.; Liu, Albert Y.

    2014-01-01

    Objectives Adherence is critical for maximizing the effectiveness of preexposure prophylaxis (PrEP) in preventing HIV infection. Strategies for promoting adherence to HIV treatment, and their potential application to PrEP adherence, have received considerable attention. However, adherence promotion strategies for prevention medications have not been well characterized and may be more applicable to PrEP. We aimed to identify adherence support interventions that have been effective in other prevention fields and could be applied in the HIV prevention context to support pill taking among PrEP users. Methods To identify adherence support interventions that could be evaluated and applied in the PrEP context, we conducted a systematic review across the following prevention fields: hypertension, latent tuberculosis infection, hyperlipidemia, oral contraceptives, osteoporosis, malaria prophylaxis, and post-exposure prophylaxis for HIV infection. We included randomized controlled trials that evaluated the efficacy of interventions to improve adherence to daily oral medications prescribed for primary prevention in healthy individuals or for secondary prevention in asymptomatic individuals. Results Our searches identified 585 studies, of which 48 studies met the eligibility criteria and were included in the review; nine evaluated multiple strategies, yielding 64 separately tested interventions. Interventions with the strongest evidence for improving adherence included complex, resource-intensive interventions, which combined multiple adherence support approaches, and low-cost, low-intensity interventions that provided education or telephone calls for adherence support. Conclusions Our review identified adherence interventions with strong evidence of efficacy across prevention fields and provides recommendations for evaluating these interventions in upcoming PrEP studies. PMID:24580813

  1. Views of policymakers, healthcare workers and NGOs on HIV pre-exposure prophylaxis (PrEP): a multinational qualitative study.

    Science.gov (United States)

    Wheelock, Ana; Eisingerich, Andreas B; Gomez, Gabriela B; Gray, Emily; Dybul, Mark R; Piot, Peter

    2012-01-01

    To examine policymakers and providers' views on pre-exposure prophylaxis (PrEP) and their willingness to support its introduction, to inform policy and practice in this emerging field. Semistructured qualitative interview study. Peru, Ukraine, India, Kenya, Uganda, Botswana and South Africa. 35 policymakers, 35 healthcare workers and 21 non-governmental organisation representatives involved in HIV prevention. Six themes emerged from the data: (1) perceived HIV prevention landscape: prevention initiatives needed to be improved and expanded; (2) PrEP awareness: 50 of 91 participants had heard of PrEP; (3) benefits of PrEP: one component of the combination prevention arsenal that could help prioritise HIV prevention, empower key populations and result in economic gains; (4) challenges of PrEP: regimen complexity, cost and cost-effectiveness, risk compensation, efficacy and effectiveness, stigmatisation and criminalisation, information and training and healthcare system capacity; (5) programmatic considerations: user eligibility, communication strategy, cost, distribution, medication and HIV testing compliance and (6) early versus late implementation: participants were divided as to whether they would support an early introduction of PrEP in their country or would prefer to wait until it has been successfully implemented in other countries, with around half of those we spoke to supporting each option. Very few said they would not support PrEP at all. Despite the multiple challenges identified, there was general willingness to support the introduction of PrEP. Yet, strengthening existing HIV prevention efforts was also deemed necessary. Our results suggest that an effective PrEP programme would be delivered in healthcare facilities and involve non-governmental organisations and the community and consider the needs of mobile populations. Comprehensive information packages and training for users and providers would be critical. The cost of PrEP would be affordable and

  2. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Directory of Open Access Journals (Sweden)

    Jae M Sevelius

    2016-10-01

    Full Text Available Introduction: Globally, transgender (“trans” women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods: Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results: To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions: In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators

  3. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices

    Science.gov (United States)

    Sevelius, Jae M; Deutsch, Madeline B; Grant, Robert

    2016-01-01

    Introduction Globally, transgender (“trans”) women are one of the key populations most disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is the newest and most promising biomedical HIV prevention intervention to date. This paper reviews relevant literature to describe the current state of the science and describes the potential role of PrEP among trans women, including a discussion of unique considerations for maximizing the impact of PrEP for this vulnerable population. Methods Available information, including but not limited to existing scientific literature, about trans women and PrEP was reviewed and critiqued based on author expertise, including PrEP clinical trials and rollout. Results To date, PrEP demonstration projects and clinical trials have largely excluded trans women, or have not included them in a meaningful way. Data collection strategies that fail to identify trans women in clinical trials and research further limit the ability to draw conclusions about trans women's unique needs and devise strategies to meet them. Gender-affirming providers and clinic environments are essential components of any sexual health programme that aims to serve trans women, as they will largely avoid settings that may result in stigmatizing encounters and threats to their identities. While there is currently no evidence to suggest drug-drug interactions between PrEP and commonly used feminizing hormone regimens, community concerns about potential interactions may limit interest in and uptake of PrEP among trans women. Conclusions In scaling up PrEP for trans women, it is essential to engage trans communities, utilize trans-inclusive research and marketing strategies and identify and/or train healthcare providers to provide gender-affirming healthcare to trans women, including transition-related care such as hormone provision. PrEP implementation guidelines must consider and address trans women's unique barriers and facilitators to uptake and

  4. Bridging the Gap Between Innovation and ELSA: The TA Program in the Dutch Nano-R&D Program NanoNed

    NARCIS (Netherlands)

    Rip, A.; Lente, H. van

    2013-01-01

    The Technology Assessment (TA) Program established in 2003 as part of the Dutch R&D consortium NanoNed is interesting for what it did, but also as an indication that there are changes in how new science and technology are pursued: the nanotechnologists felt it necessary to spend part of their fundin

  5. Bridging the Gap Between Innovation and ELSA: The TA Program in the Dutch Nano-R&D Program NanoNed

    NARCIS (Netherlands)

    Rip, A.; Lente, H. van

    2013-01-01

    The Technology Assessment (TA) Program established in 2003 as part of the Dutch R&D consortium NanoNed is interesting for what it did, but also as an indication that there are changes in how new science and technology are pursued: the nanotechnologists felt it necessary to spend part of their

  6. The promise and peril of pre-exposure prophylaxis (PrEP): using social science to inform prep interventions among female sex workers.

    Science.gov (United States)

    Syvertsen, Jennifer L; Robertson Bazzi, Angela M; Scheibe, Andrew; Adebajo, Sylvia; Strathdee, Steffanie A; Wechsberg, Wendee M

    2014-09-01

    Advances in biomedical interventions to prevent HIV offer great promise in reducing the number of new infections across sub- Saharan Africa, particularly among vulnerable populations such as female sex workers. Several recent trials testing pre-exposure prophylaxis (PrEP) have demonstrated efficacy, although others have been stopped early for futility. Given the importance and complexities of social and behavioural factors that influence biomedical approaches to prevention, we discuss several key areas of consideration moving forward, including trial participation, adherence strategies, social relationships, and the structural factors that shape PrEP interest, use, and potential effectiveness among female sex workers in sub-Saharan Africa. Our review highlights the importance of involving social scientists in clinical and community-based research on PrEP. We advocate for a shift away from a singular "re-medicalization" of the HIV epidemic to that of a "reintegration" of interdisciplinary approaches to prevention that could benefit female sex workers and other key populations at risk of acquiring HIV.

  7. Cable Supported Bridges

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    Cable supported bridges in the form of suspension bridges and cable-stayed bridges are distinguished by their ability to overcome large spans.The book concentrates on the synthesis of cable supported bridges, covering both design and construction aspects. The analytical part covers simple methods...

  8. Optimum Maintenance Strategies for Highway Bridges

    DEFF Research Database (Denmark)

    Frangopol, Dan M.; Thoft-Christensen, Palle; Das, Parag C.;

    As bridges become older and maintenance costs become higher, transportation agencies are facing challenges related to implementation of optimal bridge management programs based on life cycle cost considerations. A reliability-based approach is necessary to find optimal solutions based on minimum...... expected life-cycle costs or maximum life-cycle benefits. This is because many maintenance activities can be associated with significant costs, but their effects on bridge safety can be minor. In this paper, the program of an investigation on optimum maintenance strategies for different bridge types...... is described. The end result of this investigation will be a general reliability-based framework to be used by the UK Highways Agency in order to plan optimal strategies for the maintenance of its bridge network so as to optimize whole-life costs....

  9. High Schools that Work and Tech Prep: Improving Student Performance in Basic Skills.

    Science.gov (United States)

    Flowers, Jim

    2000-01-01

    Test results for 244 agricultural education students in High Schools that Work (HSTW) sites in North Carolina indicated that, compared to all students at HSTW sites and to college-prep students, they failed to meet HSTW goals in math, reading, and science but were making progress. Their math and science performance was higher than other vocational…

  10. Quality improvement: single-field sterile scrub, prep, and dwell for laparoscopic hysterectomy.

    Science.gov (United States)

    O'Hanlan, Katherine A; McCutcheon, Stacey Paris; McCutcheon, John G; Charvonia, Beth E

    2013-05-01

    The vulva and vaginal interior are considered a contaminated surgical area, and current OR guidelines require surgeons who are gloved and gowned at the abdominal field to avoid contact with the urethral catheter, the uterine manipulator, and the introitus or to change their gloves and even regown if contact occurs. It is our belief that the perception of the vaginal field as contaminated reflects a lack of specific standards for the preoperative cleansing of the deeper vagina and a lack of preoperative prep instructions for the combined fields. We developed a comprehensive single-field prep technique designed to improve surgical efficiency and prevent contamination of the sterile field. Combining a methodical scrub, prep, and dwell, this technique allows the entire abdomino-perineovaginal field to be treated as a single sterile field for laparoscopic procedures. Our surgical site infection rate of 1.8% when using this single-field prep technique and the subsequent surgical treatment of the abdominal, vaginal, and perineal fields as a single sterile field is well within reported norms.

  11. Moving beyond Test-Prep Pedagogy: Dialoguing with Multicultural Preservice Teachers for a Quality Education

    Science.gov (United States)

    Rodríguez, Louie F.

    2013-01-01

    In a "post-NCLB era," the schooling experiences of mostly low-income students of color continue to be consumed by a test-prep pedagogy--narrowed curriculum, low expectations, and ignored relationships. In this article the author describes a pedagogical approach using educational dialogues to engage preservice teachers to critically…

  12. Restructuring Student Experiences Using Tech Prep Mapping To Integrate Vocational and Academic Curriculum.

    Science.gov (United States)

    Pirozzoli, Don

    The growing emphasis on accountability and the demand for better prepared students is pressing institutions of higher education to examine restructuring. Student experiences represent an important arena for school restructuring, and a useful approach to changing student experiences is the Tech Prep Mapping (TPM) process. The TPM process requires…

  13. 75 FR 34148 - Voluntary Private Sector Accreditation and Certification Preparedness Program

    Science.gov (United States)

    2010-06-16

    ... requesting recommendations for standards that DHS should consider. See 73 FR 79140. After reviewing the... the adoption of three standards for use in the PS-Prep Program and sought public comment. See 74...

  14. Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP.

    Directory of Open Access Journals (Sweden)

    Albert Y Liu

    facilitate adherence measurement in real-world settings and merit further investigation in upcoming PrEP implementation studies and programs.ClinicalTrials.gov NCT00903084.

  15. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Science.gov (United States)

    Ravasi, Giovanni; Grinsztejn, Beatriz; Baruch, Ricardo; Guanira, Juan Vicente; Luque, Ricardo; Cáceres, Carlos F; Ghidinelli, Massimo

    2016-01-01

    Introduction Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP) is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint negotiation and

  16. Towards a fair consideration of PrEP as part of combination HIV prevention in Latin America

    Directory of Open Access Journals (Sweden)

    Giovanni Ravasi

    2016-10-01

    Full Text Available Introduction: Despite progress in scaling up antiretroviral treatment, HIV prevention strategies have not been successful in significantly curbing HIV incidence in Latin America. HIV prevention interventions need to be expanded to target the most affected key populations with a combination approach, including new high impact technologies. Oral pre-exposure prophylaxis (PrEP is recommended as additional prevention choice for individuals at higher risk of infection and could become a cost-effective prevention tool. We discuss the barriers and solutions for a fair consideration of PrEP as part of combination HIV prevention strategies in Latin America. Discussion: Although demonstration projects are ongoing or being planned in a number of countries, to date no Latin American country has implemented a public PrEP programme. The knowledge of policymakers about PrEP implementation needs to be strengthened, and programmatic guidance and cost estimate tools need to be developed to support adequate planning. Despite high levels of awareness among health providers, especially if engaged in HIV or key population care, willingness to prescribe PrEP is still low due to the lack of national policies and guidelines. Key populations, especially men who have sex with men, transgender women and sex workers, have been engaged in demonstration projects, and qualitative research shows high awareness and willingness to use PrEP, especially if accessible in the public sector for free or at affordable price. Concerns of safety, adherence, effectiveness and risk compensation need to be addressed through targeted social communication strategies to improve PrEP knowledge and stimulate demand. Alliance among policymakers, civil society and representatives from key populations, healthcare providers and researchers will be critical for the design and successful implementation of PrEP demonstration projects of locally adapted delivery models. The use of mechanisms of joint

  17. Bridges in Complex Networks

    CERN Document Server

    Wu, Ang-Kun; Liu, Yang-Yu

    2016-01-01

    A bridge in a graph is an edge whose removal disconnects the graph and increases the number of connected components. We calculate the fraction of bridges in a wide range of real-world networks and their randomized counterparts. We find that real networks typically have more bridges than their completely randomized counterparts, but very similar fraction of bridges as their degree-preserving randomizations. We define a new edge centrality measure, called bridgeness, to differentiate the importance of a bridge in damaging a network. We find that certain real networks have very large average and variance of bridgeness compared to their degree-preserving randomizations and other real networks. Finally, we offer an analytical framework to calculate the bridge fraction and average bridgeness for uncorrelated random networks with arbitrary degree distributions.

  18. Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.

    Science.gov (United States)

    Risolino, Maurizio; Mandia, Nadia; Iavarone, Francescopaolo; Dardaei, Leila; Longobardi, Elena; Fernandez, Serena; Talotta, Francesco; Bianchi, Fabrizio; Pisati, Federica; Spaggiari, Lorenzo; Harter, Patrick N; Mittelbronn, Michel; Schulte, Dorothea; Incoronato, Mariarosaria; Di Fiore, Pier Paolo; Blasi, Francesco; Verde, Pasquale

    2014-09-01

    Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis. Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplastic transformation by competing with myeloid ecotropic integration site 1 for binding to the common heterodimeric partner Pbx1. Epithelial-mesenchymal transition (EMT) is controlled by complex networks of proinvasive transcription factors responsive to paracrine factors such as TGF-β. Here we show that, in addition to inhibiting primary tumor growth, PREP1 is a novel EMT inducer and prometastatic transcription factor. In human non-small cell lung cancer (NSCLC) cells, PREP1 overexpression is sufficient to trigger EMT, whereas PREP1 down-regulation inhibits the induction of EMT in response to TGF-β. PREP1 modulates the cellular sensitivity to TGF-β by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation through mechanisms dependent, at least in part, on PREP1-mediated transactivation of a regulatory element in the SMAD3 first intron. Along with the stabilization and accumulation of PBX1, PREP1 induces the expression of multiple activator protein 1 components including the proinvasive Fos-related antigen 1 (FRA-1) oncoprotein. Both FRA-1 and PBX1 are required for the mesenchymal changes triggered by PREP1 in lung tumor cells. Finally, we show that the PREP1-induced mesenchymal transformation correlates with significantly increased lung colonization by cells overexpressing PREP1. Accordingly, we have detected PREP1 accumulation in a large number of human brain metastases of various solid tumors, including NSCLC. These findings point to a novel role of the PREP1 homeoprotein in the control of the TGF-β pathway, EMT, and metastasis in NSCLC.

  19. "Support Your Client at the Space That They're in": HIV Pre-Exposure Prophylaxis (PrEP) Prescribers' Perspectives on PrEP-Related Risk Compensation.

    Science.gov (United States)

    Calabrese, Sarah K; Magnus, Manya; Mayer, Kenneth H; Krakower, Douglas S; Eldahan, Adam I; Hawkins, Lauren A Gaston; Underhill, Kristen; Hansen, Nathan B; Kershaw, Trace S; Betancourt, Joseph R; Dovidio, John F

    2017-04-01

    Despite the demonstrated effectiveness of HIV pre-exposure prophylaxis (PrEP) and evidence that most PrEP users do not engage in risk compensation (i.e., increased risk behavior due to a perceived decrease in HIV susceptibility), some healthcare providers report patient risk compensation to be a deterrent to prescribing PrEP. Overcoming this barrier is essential to supporting PrEP access and uptake among people at risk for HIV. To inform such efforts, this qualitative study explored PrEP-related risk compensation attitudes among providers with firsthand experience prescribing PrEP. US-based PrEP providers (n = 18), most of whom were HIV specialists, were recruited through direct outreach and referral from colleagues and other participants. Individual 90-min semistructured interviews were conducted by phone or in person from September 2014 through February 2015, transcribed, and thematically analyzed. Three attitudinal themes emerged: (1) providers' role is to support patients in making informed decisions, (2) risk behavior while taking PrEP does not fully offset PrEP's protective benefit (i.e., PrEP confers net protection, even with added behavioral risk), and (3) PrEP-related risk compensation is unduly stigmatized within and beyond the healthcare community. Participants were critical of other healthcare providers' negative judgment of patients and reluctance to prescribe PrEP due to anticipated risk compensation. Several providers also acknowledged an evolution in their thinking from initial ambivalence toward greater acceptance of PrEP and PrEP-related behavior change. PrEP providers' insights about risk compensation may help to address unsubstantiated concerns about PrEP-related risk compensation and challenge the acceptability of withholding PrEP on these grounds.

  20. Are we PREPared? Quality of information available to patients in the UK about PREP on the internet

    Directory of Open Access Journals (Sweden)

    S Duncan

    2012-11-01

    Full Text Available Professional bodies in the UK (BASHH/BHIVA do not currently recommended pre-exposure prophylaxis (PREP to prevent HIV aquisition for men who have sex with men (MSM [1]. Conversely, although Federal Drug Administration approval is awaited, the Centers for Disease Control (CDC have issued clinicians in the USA with interim guidance to facilitate PREP prescriptions [2]. Increasingly patients search the internet for information on HIV treatment, but disparate international policy can lead to confusing patient messages. This study was conducted to systematically assess the quality of internet information available to patients in the UK about PREP. More than 90% of internet searches in the UK are performed using ‘Google.co.uk’ and ‘Bing’ [3]. Using pre-specified criteria, we reviewed the first 100 hits retrieved from each search engine when the following searches were performed: [“HIV pre-exposure prophylaxis”]; [“HIV PREP”]; [“HIV PREP guidelines”]; [“HIV PREP guidelines UK”]; [“truvada prophylaxis HIV”]. Of 172 unique websites identified, 124 websites were active at the time of the review (July 2012. 33 websites were links to academic journals including commentaries and clinical trials, not intended to specifically provide patient information; 5 were internet portals directing users to alternative sites and 10 websites contained no information about PREP. Of the remaining 76 websites, 28 were written by medical professionals and 48 were written by journalists, where 7/48 (15% were individual blogs. 64/76 (84% contained a definition of PREP; 63/76 (83% discussed the rationale and 58/76 (76% reported efficacy data. Advantages and disadvantages of PREP were presented in 56/76 (74% and 41/76 (54% of websites respectively. Only 21/76 (28% of sites referenced existing national guidelines (CDC/BASHH. A minority of sites described the current clinical practice in the UK (7/76, 9% with an even smaller number presenting the

  1. Are Thai MSM willing to take PrEP for HIV prevention? An analysis of attitudes, preferences and acceptance.

    Directory of Open Access Journals (Sweden)

    Ana Wheelock

    Full Text Available OBJECTIVE: We aimed to understand the attitudes, preferences and acceptance of oral and parenteral PrEP among men who have sex with men (MSM in Thailand. BACKGROUND: Pre-exposure prophylaxis (PrEP, the use of antiretrovirals to prevent HIV acquisition, has shown promising results in recent trials. To assess the potential impact of this new HIV prevention method, in addition to efficacy data, we need to understand which psychosocial factors are likely to determine its uptake among members of potential user groups. METHODS AND FINDINGS: Surveys of willingness to use PrEP products were administered to MSM. Spearman's rank tests were used to uncover associations between questionnaire items. Mann-Whitney tests were performed to ascertain differences between groups. Conjoint analysis was used to examine the attitudes and preferences of MSM towards PrEP attributes. Most participants were willing to consider taking PrEP (39.2% "yes, definitely" and 49.2% "yes, probably" and perceived PrEP as giving them new possibilities in their lives (38.5% "a lot of hope" and 55.8% "some hope", even after being instructed of potential side effects and costs. HIV testing was considered the most important attribute and a daily pill and longer lasting injection in the arm were the preferred routes of administration. CONCLUSIONS: Despite its multiple challenges, MSM in Thailand would be willing to take PrEP, even if they had to experience inconvenience and expense. If PrEP were to be implemented in Thailand, our findings show that its uptake could be considerable.

  2. 23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR...

  3. 23 CFR 661.57 - How is a list of deficient bridges to be generated?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How is a list of deficient bridges to be generated? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.57 How is a list of deficient bridges to be generated? (a) In consultation with the BIA, a list of deficient BIA IRR bridges will...

  4. PREPARATIVE ISOLATION AND PURIFICATION OF CHEMICAL CONSTITUENTS OF BELAMCANDA BY MPLC, HSCCC AND PREP-HPLC

    Science.gov (United States)

    Wang, Xiaohong; Liang, Yong; Peng, Cuilin; Xie, Huichun; Pan, Man; Zhang, Tianyou; Ito, Yoichiro

    2010-01-01

    Combined with medium-pressure liquid chromatography (MPLC) and preparative high-pressure liquid chromatography (Prep-HPLC), high-speed countercurrent chromatography (HSCCC) was successfully applied for separation and purification of isoflavonoids from the extract of belamcanda. HSCCC separation was performed on a two-phase solvent system composed of methyl tert-butyl ether -ethyl acetate - n-butyl alcohol – acetonitrile −0.1% aqueous trifluoroacetic acid at a volume radio of 1:2:1:1:5. Semi-purified peak fractions from HSCCC separation were further purified by Prep-HPLC. Nine well-separated fractions were analyzed by HPLC-UV absorption spectrometry to determine their purities and characterized with ESI-MSn. Except for peaksland VII (unknown) seven compounds were identified as apocynin (peak II), mangiferin (peak III), 7-O-methylmangiferin (peak IV), hispidulin (peak V), 3′-hydroxyltectoridin (peak VI), iristectorin B (peak VII), isoiridin (peak IX). PMID:21552369

  5. Swords, Shields, and the Fight for Our Children: Lessons from Urban Prep

    Science.gov (United States)

    King, Tim

    2011-01-01

    The grim statistics are well known, but bear repeating: in Chicago, close to 60% of Black boys do not graduate from high school, and only one in forty receive a bachelor's degree by age 25. In the fall of 2006, Urban Prep Charter Academy for Young Men-Englewood Campus, the nation's first all-male charter public high school, was opened. In 2010 and…

  6. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    OpenAIRE

    Arcelino Farias-Neto; Edna Maria da Cunha Ferreira Gomes; Alfonso Sánchez-Ayala; Alejandro Sánchez-Ayala; Larissa Soares Reis Vilanova

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents e...

  7. Taizhou Yangtze River Bridge

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Taizhou Bridge lies between Taizhou, Zhenjiang and Changzhou City in Jiangsu Province. The total length of Taizhou Bridge is 62.088 kin. The whole line is designed by freeway codes with six lanes in two directions. The wholeinvestment is 9.37 billion RMB and the planned construction duration is 5.5 years. The main bridge crossing the Yangtze River is a continuous three-pylon two-span suspension bridge with the main span of 1 080 m. The bridge system is realized for the first time and ranks first in the world until now.

  8. Secrecy, empowerment and protection: positioning PrEP in KwaZulu-Natal, South Africa.

    Science.gov (United States)

    Govender, Eliza; Mansoor, Leila; MacQueen, Kate; Abdool Karim, Quarraisha

    2017-11-01

    The release of World Health Organisation guidelines recommending the prophylactic use of daily Truvada(®) for all populations at high risk of acquiring HIV opens the way for implementation of oral pre-exposure prophylaxis (PrEP). The impact of new prevention technologies is, however, dependent on demand creation strategies such as user awareness, acceptability and access, which in turn are influenced by sociocultural and gender norms. This study was conducted in three locations in KwaZulu-Natal, urban, rural and peri-urban, with six participatory workshops. Knowledge, desirable features of a product and demand positioning for PrEP were assessed using a participatory action media research process which included art-based activities and group discussion using a semi-structured interview schedule. The data were analysed using thematic analysis. The key themes that emerged in relation to product adoption were: ability to maintain secrecy of product use; the need for agency with personal choices around HIV prevention; and an increased desire for HIV protection. Findings reaffirm the influence of user engagement in understanding the sociocultural dynamics that influence demand creation for PrEP adoption.

  9. No association between the PREP gene and lithium responsive bipolar disorder

    Directory of Open Access Journals (Sweden)

    Grof Paul

    2007-02-01

    Full Text Available Abstract Background Bipolar disorder (BD is a major psychiatric condition that commonly requires prophylactic and episodic treatment. Lithium (Li has been used for over 40 years now as an effective prophylactic agent. Response to Li treatment seems to be, at least in part, genetically determined. Although we ignore how Li specifically prevents mood episodes, it has previously been suggested that Li exerts an effect on the phosphoinositide pathway, and more recently, it has been proposed that Li may modulate prolyl endopeptidase (PREP. Methods In this study we carried out an association study looking at the PREP gene, located on ch 6q22. Five intronic single nucleotide polymorphisms (SNP, three coding SNPs and one SNP in the 5' UTR were investigated for their frequency in a BD sample of 180 excellent Li responders, 69 Li nonresponders and 126 controls. Genotyping was carried out using the SNaPshot reaction from Applied Biosystems, which is a modified fluorescent single base pair extension procedure. Results Following correction for multiple testing, no significant genotypic, allelic or estimated haplotypic differences were found between responders and nonresponders or between BD patients and controls. Conclusion PREP is an interesting candidate gene to investigate in genetic studies of BD, but our findings do not support the hypothesis that genetic variation in this gene plays a major role in the etiology of BD or Li response.

  10. Building the clinical bridge: an Australian success.

    Science.gov (United States)

    Wallis, Marianne; Chaboyer, Wendy

    2012-01-01

    Nursing effectiveness science includes primary, secondary, and translational, clinically focused research activities which aim to improve patient or client outcomes. It is imperative, for the successful conduct of a program of nursing effectiveness science, that a clinical bridge is established between academic and healthcare service facilities. An Australian example of the development of a robust clinical bridge through the use of jointly funded positions at the professorial level is outlined. In addition, an analysis of the practical application of Lewin's model of change management and the contribution of both servant and transformational leadership styles to the bridge building process is provided.

  11. Building the Clinical Bridge: An Australian Success

    Directory of Open Access Journals (Sweden)

    Marianne Wallis

    2012-01-01

    Full Text Available Nursing effectiveness science includes primary, secondary, and translational, clinically focused research activities which aim to improve patient or client outcomes. It is imperative, for the successful conduct of a program of nursing effectiveness science, that a clinical bridge is established between academic and healthcare service facilities. An Australian example of the development of a robust clinical bridge through the use of jointly funded positions at the professorial level is outlined. In addition, an analysis of the practical application of Lewin’s model of change management and the contribution of both servant and transformational leadership styles to the bridge building process is provided.

  12. Dynamics and statics of nonaxisymmetric and symmetric liquid bridges

    Science.gov (United States)

    Alexander, J. Iwan D.; Resnick, Andrew H.; Kaukler, William F.; Zhang, Yiqiang

    1994-01-01

    This program of theoretical and experimental ground-based research focuses on the understanding of the dynamics and stability limits of nonaxisymmetric and symmetric liquid bridges. There are three basic objectives: First, to determine the stability limits of nonaxisymmetric liquid bridges held between non-coaxial parallel disks, Second, to examine the dynamics of nonaxisymmetric bridges and nonaxisymmetric oscillations of initially axisymmetric bridges. The third objective is to experimentally investigate the vibration sensitivity of liquid bridges under terrestrial and low gravity conditions. Some of these experiments will require a low gravity environment and the ground-based research will culminate in a definitive flight experiment.

  13. LPN/ADN Bridge Course. Instructor's Guide.

    Science.gov (United States)

    Barrett, Jan; And Others

    This curriculum guide has been constructed in order to bridge the skills gap between licensed practical nursing (LPN) programs and associate degree nursing (ADN) programs in Missouri. The curriculum was developed through a cooperative effort by persons from both sectors. The curriculum contains four major units, each consisting of several lessons,…

  14. Building Bridges to Better Bilingual Education.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Bilingual Education.

    This information dissemination report presents a brief introduction to the Building Bridges to Better Bilingual Education Program of the Central Board of Education of the City of New York. The primary aim of the program is to promote the linguistic and academic progress of those Title I eligible Spanish-speaking children whose achievement levels…

  15. International Contribution to the Highway Agency's Bridge Related Research

    DEFF Research Database (Denmark)

    Nowak, A. S.; Thoft-Christensen, Palle

    The objective of this paper is to summarize recent contributions of international experts to the research program sponsored by the Highways Agency. An efficient management of existing bridges requires methodology for an accurate evaluation of the actual loads and load carrying capacity and predic......The objective of this paper is to summarize recent contributions of international experts to the research program sponsored by the Highways Agency. An efficient management of existing bridges requires methodology for an accurate evaluation of the actual loads and load carrying capacity...... of reliability models for analysis of bridges subjected to corrosion and fatigue, and reliability-based optimization of maintenance strategies for bridges....

  16. Study and Application of Highway Bridge-erecting Machine JQC40A%JQC40A型公路架桥机的研究与应用

    Institute of Scientific and Technical Information of China (English)

    党春太; 叶文

    2000-01-01

    This paper introduces advanced bridge-erecting structure with taking beam laterally,bridge-erecting program and the work situation.Development trend of highway bridge-erecting machine in the future in China is predicted.

  17. Bridge Crossing Simulator

    Science.gov (United States)

    2014-10-07

    Requirement BCS Computer-controlled hydraulic actuation system to impart simulated crossing loads on an entire bridge structure undergoing fatigue test ...structure. Bridge test site with prepared embankments corresponding to the span and bank condition requirements of the bridge under test Conduct real...Center (AEC). (5) Sample size and number of crossings required. The number of required simulated crossings to conduct fatigue testing per the

  18. Acceptability of HIV Pre-Exposure Prophylaxis (PrEP) and Implementation Challenges Among Men Who Have Sex with Men in India: A Qualitative Investigation.

    Science.gov (United States)

    Chakrapani, Venkatesan; Newman, Peter A; Shunmugam, Murali; Mengle, Shruta; Varghese, Jarvis; Nelson, Ruban; Bharat, Shalini

    2015-10-01

    This qualitative study explored the acceptability of HIV pre-exposure prophylaxis (PrEP) among MSM in India, and identified facilitators and barriers to future PrEP uptake. In 2014, we conducted 10 focus groups (n=61) among a purposive sample of diverse MSM recruited through community-based organizations in Chennai and Mumbai, and 10 key informant interviews with community leaders and health care providers. Participants' mean age was 26.1 years (SD 4.8); 62% completed secondary education, and 42% engaged in sex work. No focus group participants had heard of PrEP, but once explained, most reported they would likely use it. PrEP was alternately perceived as a 'back-up plan', a condom substitute, or a burden with concurrent condom use. Facilitators were potential for covert use, sex without condoms, and anxiety-less sex. Potential barriers emerged around stigma associated with PrEP use, fear of disclosures to one's family, wife, or male steady partner, and being labeled as HIV-positive or promiscuous by peers. Preferences emerged for intermittent rather than daily PrEP use, injectable PrEP, and free or subsidized access through community organizations or government hospitals. Key informants expressed additional concerns about risk compensation, non-adherence, and impact on ART availability for treatment. Demonstration projects are needed in India to support PrEP implementation tailored for at-risk MSM. Educational interventions for MSM should address concerns about PrEP effectiveness, side effects, and mitigate risk compensation. Community engagement may facilitate broad acceptability and challenge stigma around PrEP use. Importantly, provision of free or subsidized PrEP is necessary to making implementation feasible among low socioeconomic status MSM in India.

  19. Semiconductor bridge (SCB) detonator

    Science.gov (United States)

    Bickes, Jr., Robert W.; Grubelich, Mark C.

    1999-01-01

    The present invention is a low-energy detonator for high-density secondary-explosive materials initiated by a semiconductor bridge igniter that comprises a pair of electrically conductive lands connected by a semiconductor bridge. The semiconductor bridge is in operational or direct contact with the explosive material, whereby current flowing through the semiconductor bridge causes initiation of the explosive material. Header wires connected to the electrically-conductive lands and electrical feed-throughs of the header posts of explosive devices, are substantially coaxial to the direction of current flow through the SCB, i.e., substantially coaxial to the SCB length.

  20. Bridging the Gap

    OpenAIRE

    Kramer Overgaard, Majken; Broeng, Jes; Jensen, Monika Luniewska; Murdock, Karen; Schmidt, Iben Julie

    2015-01-01

    Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures. Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ve...

  1. Bridging the Gap

    DEFF Research Database (Denmark)

    Kramer Overgaard, Majken; Broeng, Jes; Jensen, Monika Luniewska;

    Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures.......Bridging the Gap (BtG) is a 2-year project funded by The Danish Industry Foundation. The goal of Bridging the Gap has been to create a new innovation model which will increase the rate at which Danish universities can spinout new technology ventures....

  2. 23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

    Science.gov (United States)

    2010-04-01

    ... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available...

  3. Global Bridges: building an international network for tobacco dependence treatment

    Directory of Open Access Journals (Sweden)

    Katie Kemper

    2016-03-01

    Full Text Available Global Bridges, hosted at Mayo Clinic, is the most diverse international network of healthcare professionals dedicated to tobacco dependence treatment. Global Bridges works with grantees and partners in all six WHO regions to educate healthcare providers on evidence-based treatment and advocate for effective tobacco policy. This session will describe accomplishments and lessons learned in the Global Bridges program over nearly six years, and opportunities to better integrate cessation support into comprehensive tobacco control.

  4. The Process of Retirement Planning Scale (PRePS): development and validation.

    Science.gov (United States)

    Noone, Jack H; Stephens, Christine; Alpass, Fiona

    2010-09-01

    Although a substantial proportion of the western population is approaching retirement age, little is known about how they are preparing for the future. Much attention has been paid to the consumption of educational material and retirement wealth in the present literature, but the process of retirement planning has been ignored. S. L. Friedman and E. K. Scholnick's (1997) theoretical model provided the basis for a comprehensive measure of retirement planning. According to their process theory, individuals develop an understanding of the problem, set goals, make a decision to start preparing, and finally undertake the behaviors needed to fulfill their goals. Fifty-two items were developed to assess each stage of the planning process for financial, health, lifestyle, and psychosocial retirement planning. These were tested on a population sample of 1,449 New Zealanders aged 49-60. Confirmatory factor analysis, bivariate correlations, and hierarchical regression provided support for the valid use of the measure. Necessary antecedents, such as the tendency to look to the future, and locus of control were significantly related to the Process of Retirement Planning Scale (PRePS). The PRePS also outperformed retirement planning measures used in the Health and Retirement Study (F. T. Juster & R. Suzman, 1995) after controlling for socioeconomic and psychological variables. This measure will enable social policy makers to determine which stages of retirement planning require support and intervention. The PRePS will also help to determine which domains of retirement planning predict well-being in later life and the factors which differentiate those who are planning from those who are not.

  5. Sexual Behavior, Risk Compensation, and HIV Prevention Strategies Among Participants in the San Francisco PrEP Demonstration Project: A Qualitative Analysis of Counseling Notes.

    Science.gov (United States)

    Carlo Hojilla, J; Koester, Kimberly A; Cohen, Stephanie E; Buchbinder, Susan; Ladzekpo, Deawodi; Matheson, Tim; Liu, Albert Y

    2016-07-01

    Pre-exposure prophylaxis (PrEP) is a viable HIV prevention strategy but risk compensation could undermine potential benefits. There are limited data that examine this phenomenon outside of clinical trials. We conducted a qualitative analysis of counseling notes from the San Francisco site of the US PrEP demonstration project to assess how men who have sex with men used PrEP as a prevention strategy and its impact on their sexual practices. Four major themes emerged from our analysis of 130 distinct notes associated with 26 participants. Prevention strategy decision-making was dynamic, often influenced by the context and perceived risk of a sexual encounter. Counselors noted that participants used PrEP in conjunction with other health promotion strategies like condoms, asking about HIV status of their sex partners, and seroadaptation. With few exceptions, existing risk reduction strategies were not abandoned upon initiation of PrEP. Risk-taking behavior was 'seasonal' and fluctuations were influenced by various personal, psychosocial, and health-related factors. PrEP also helped relieve anxiety regarding sex and HIV, particularly among serodiscordant partners. Understanding sexual decision-making and how PrEP is incorporated into existing prevention strategies can help inform future PrEP implementation efforts.

  6. Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study

    DEFF Research Database (Denmark)

    Schledermann, Doris; Hyldebrandt, Tina; Ejersbo, Dorthe;

    2007-01-01

    The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening ...

  7. Oral pre-exposure prophylaxis (PrEP) for prevention of HIV in serodiscordant heterosexual couples in the United States: opportunities and challenges.

    Science.gov (United States)

    McMahon, James M; Myers, Julie E; Kurth, Ann E; Cohen, Stephanie E; Mannheimer, Sharon B; Simmons, Janie; Pouget, Enrique R; Trabold, Nicole; Haberer, Jessica E

    2014-09-01

    Oral HIV pre-exposure prophylaxis (PrEP) is a promising new biomedical prevention approach in which HIV-negative individuals are provided with daily oral antiretroviral medication for the primary prevention of HIV-1. Several clinical trials have demonstrated efficacy of oral PrEP for HIV prevention among groups at high risk for HIV, with adherence closely associated with level of risk reduction. In the United States (US), three groups have been prioritized for initial implementation of PrEP-injection drug users, men who have sex with men at substantial risk for HIV, and HIV-negative partners within serodiscordant heterosexual couples. Numerous demonstration projects involving PrEP implementation among MSM are underway, but relatively little research has been devoted to study PrEP implementation in HIV-serodiscordant heterosexual couples in the US. Such couples face a unique set of challenges to PrEP implementation at the individual, couple, and provider level with regard to PrEP uptake and maintenance, adherence, safety and toxicity, clinical monitoring, and sexual risk behavior. Oral PrEP also provides new opportunities for serodiscordant couples and healthcare providers for primary prevention and reproductive health. This article provides a review of the critical issues, challenges, and opportunities involved in the implementation of oral PrEP among HIV-serodiscordant heterosexual couples in the US.

  8. Numerical analysis on solidification process and heat transfer of FGH95 superalloy droplets during PREP

    Institute of Scientific and Technical Information of China (English)

    Huanming Chen; Benfu Hu; Yiwen Zhang; Quanmao Yu; Huiying Li

    2003-01-01

    In order to understand the relation between microstructure of superalloy powders and its solidification progress, the processing parameters are optimized during plasma rotating electrode processing (PREP). It was predicted from the results that the droplet velocities, droplet temperature, and fractional solidification with flight time about FGH95 superalloy droplet have been carried out based on Newtonian heat transfer formulation coupled with the classical heterogeneous nucleation and the specific solidification process. It has been found that the droplet dynamic and thermal behavior is strongly affected by the distribution of droplet diameters,the proportion of cooling atmosphere, but is relatively unaffected by the droplet superheat.

  9. Sustainable Bridge Infrastructure Procurement

    DEFF Research Database (Denmark)

    Safi, Mohammed; Du, Guangli; Simonsson, Peter

    2016-01-01

    The lack of a flexible but systematic approach for integrating lifecycle aspects into bridge investment decisions is a major obstacle hindering the procurement of sustainable bridge infrastructures. This paper addresses this obstacle by introducing a holistic approach that agencies could use...

  10. Principles of Bridge Reliability

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Nowak, Andrzej S.

    The paper gives a brief introduction to the basic principles of structural reliability theory and its application to bridge engineering. Fundamental concepts like failure probability and reliability index are introduced. Ultimate as well as serviceability limit states for bridges are formulated...

  11. Bridge the Gap

    DEFF Research Database (Denmark)

    Marselis, Randi Lorenz

    2017-01-01

    This article focuses on photo projects organised for teenage refugees by the Society for Humanistic Photography (Berlin, Germany). These projects, named Bridge the Gap I (2015), and Bridge the Gap II (2016), were carried out in Berlin and brought together teenagers with refugee and German...

  12. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Directory of Open Access Journals (Sweden)

    Luís Miguel Rocha

    2014-11-01

    Full Text Available Introduction: Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013 were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods: A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results: A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%; those that were aware, had heard of it trough CheckpointLx (31%, internet (22% or health professionals (20%. 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%. Type of PrEP preferred was oral, a pill a day (43%, followed by oral, intermittent intake (32%. Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions: In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP, according to MSM Risk Index

  13. Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair

    Science.gov (United States)

    Miguel Rocha, Luís; José Campos, Maria; Brito, João; Fuertes, Ricardo; Rojas, Jesus; Pinto, Nuno; Mendão, Luís; Esteves, Julio

    2014-01-01

    Introduction Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], according to the 2014 USA PrEP guidelines [3]. Studies about PrEP acceptability and implementation support policies aimed at increasing and rolling out its use. Hence, the exploratory study about PrEP acceptability in MSM at Lisbon. Materials and Methods A street-based intercept survey, adapted from Mantell et al. study [4], was the one used on MSM attending the 2014 Lisbon pride fair. The survey included socio-demographic data, PrEP awareness and readiness to use it, probability of MSM's social network to also use it, promptness to join PrEP-related studies, type of PrEP warranted and condomless anal sex practice in the last six months. Results A total of 110 HIV negative Portuguese MSM responded, with a median age of 33% and 84% of them identified themselves as gay. A majority of MSM were unaware of PrEP (59%); those that were aware, had heard of it trough CheckpointLx (31%), internet (22%) or health professionals (20%). 66% were likely or very likely to participate in PrEP-related studies. 57% of MSM were likely or very likely to use PrEP if available and reported that some, if not almost all of their social network, will do it too (70%). Type of PrEP preferred was oral, a pill a day (43%), followed by oral, intermittent intake (32%). Overall 41% of MSM had condomless anal sex practice in the last six months. Conclusions In this MSM Portuguese sample, a general willingness to adopt PrEP was predominant, specially the oral daily intake. Forty-one percent of participants had had condomless anal sex practice in the last six months and therefore fitted within the criteria to be on Pre-Exposure Prophylaxis (PrEP), according to MSM Risk Index in 2014 USA PrEP

  14. 桥梁加铺结构层方案研究%Research for the Overlay Structure Layer Program of Bridges

    Institute of Scientific and Technical Information of China (English)

    王婷宇

    2014-01-01

    Engineering background with a bridge span of 8 m which need top up 30.5 cm,this pa-per intends to use the way that directly paving the structural layer instead of jacking,make it contact with the road surface.By theoretical calculations verified that the scheme is feasible,provide reference for simi-lar projects.%以耒宜高速公路需顶升30.5 cm 且跨径为8 m的桥梁为工程背景,拟采用不顶升,直接加铺结构层方式,使之与路面顺接。通过理论计算验证了该方案切实可行,为类似工程提供参考。

  15. Alcohol based surgical prep solution and the risk of fire in the operating room: a case report

    Directory of Open Access Journals (Sweden)

    Gupta Rajiv

    2008-04-01

    Full Text Available Abstract A few cases of fire in the operating room are reported in the literature. The factors that may initiate these fires are many and include alcohol based surgical prep solutions, electrosurgical equipment, flammable drapes etc. We are reporting a case of fire in the operating room while operating on a patient with burst fracture C6 vertebra with quadriplegia. The cause of the fire was due to incomplete drying of the covering drapes with an alcohol based surgical prep solution. This paper discusses potential preventive measures to minimize the incidence of fire in the operating room.

  16. Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature.

    Science.gov (United States)

    Koechlin, Florence M; Fonner, Virginia A; Dalglish, Sarah L; O'Reilly, Kevin R; Baggaley, Rachel; Grant, Robert M; Rodolph, Michelle; Hodges-Mameletzis, Ioannis; Kennedy, Caitlin E

    2016-11-29

    Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP. A comprehensive search strategy reviewed three electronic databases of articles and HIV-related conference abstracts (January 1990-April 2015). Data abstraction used standardised forms to categorise by population groups and relevant themes. Of 3068 citations screened, 76 peer-reviewed articles and 28 conference abstracts were included. Geographic coverage was global. Most studies (N = 78) evaluated hypothetical use of PrEP, while 26 studies included individuals who actually took PrEP or placebo. Awareness of PrEP was low, but once participants were presented with information about PrEP, the majority said they would consider using it. Concerns about safety, side effects, cost and effectiveness were the most frequently cited barriers to use. There was little indication of risk compensation. Healthcare providers would consider prescribing PrEP, but need more information before doing so. Findings from a rapidly expanding evidence base suggest that the majority of populations most likely to benefit from PrEP feel positively towards it. These same populations would benefit from overcoming current implementation challenges with the shortest possible delay.

  17. Complex and Conflicting Social Norms: Implications for Implementation of Future HIV Pre-Exposure Prophylaxis (PrEP Interventions in Vancouver, Canada.

    Directory of Open Access Journals (Sweden)

    Rod Knight

    Full Text Available HIV Pre-Exposure Prophylaxis (PrEP has been found to be efficacious in preventing HIV acquisition among seronegative individuals in a variety of risk groups, including men who have sex with men and people who inject drugs. To date, however, it remains unclear how socio-cultural norms (e.g., attitudes towards HIV; social understandings regarding HIV risk practices may influence the scalability of future PrEP interventions. The objective of this study is to assess how socio-cultural norms may influence the implementation and scalability of future HIV PrEP interventions in Vancouver, Canada.We conducted 50 interviews with young men (ages 18-24 with a variety of HIV risk behavioural profiles (e.g., young men who inject drugs; MSM. Interviews focused on participants' experiences and perceptions with various HIV interventions and policies, including PrEP.While awareness of PrEP was generally low, perceptions about the potential personal and public health gains associated with PrEP were interconnected with expressions of complex and sometimes conflicting social norms. Some accounts characterized PrEP as a convenient form of reliable protection against HIV, likening it to the female birth control pill. Other accounts cast PrEP as a means to facilitate 'socially unacceptable' behaviour (e.g., promiscuity. Stigmatizing rhetoric was used to position PrEP as a tool that could promote some groups' proclivities to take 'risks'.Stigma regarding 'risky' behaviour and PrEP should not be underestimated as a serious implementation challenge. Pre-implementation strategies that concomitantly aim to improve knowledge about PrEP, while addressing associated social prejudices, may be key to effective implementation and scale-up.

  18. Eco prep: the economical preparation of ceramic bodies; Ecoprep: la preparacion rentable de masas ceramicas

    Energy Technology Data Exchange (ETDEWEB)

    Luders, M.; Walter, H. J.; Nold, P.; Lobe, R.; Muller, M.; Gerl, S.

    2012-07-01

    Eco prep (Economic Preparation) is the sustainable technology for preparing ceramic bodies with a minimum consumption of resources. It has a huge impact on the energy balance and eliminates the need for additives to generate a high-quality slip to make granules. In consequence Eco prep delivers a significant reduction in production costs, bringing an investment in this technology to the break-even point after a very short time. Reduction in water consumption and additives and the use of new raw materials are other advantages that impulse the implementation of this production technology, as well as important reduction of CO{sub 2} emissions, contributing to meeting the goals of the Kyoto Protocol. In short: A technology already successfully applied in different industries for decades, that includes a compendium of measures based on saving reductions in a range from 66% (energy, water,) and 100% (additives, deflocculants, etc.) and will mark the future in micro granulation processes also in the ceramic industry. (Author)

  19. The PREP pipeline: standardized preprocessing for large-scale EEG analysis.

    Science.gov (United States)

    Bigdely-Shamlo, Nima; Mullen, Tim; Kothe, Christian; Su, Kyung-Min; Robbins, Kay A

    2015-01-01

    The technology to collect brain imaging and physiological measures has become portable and ubiquitous, opening the possibility of large-scale analysis of real-world human imaging. By its nature, such data is large and complex, making automated processing essential. This paper shows how lack of attention to the very early stages of an EEG preprocessing pipeline can reduce the signal-to-noise ratio and introduce unwanted artifacts into the data, particularly for computations done in single precision. We demonstrate that ordinary average referencing improves the signal-to-noise ratio, but that noisy channels can contaminate the results. We also show that identification of noisy channels depends on the reference and examine the complex interaction of filtering, noisy channel identification, and referencing. We introduce a multi-stage robust referencing scheme to deal with the noisy channel-reference interaction. We propose a standardized early-stage EEG processing pipeline (PREP) and discuss the application of the pipeline to more than 600 EEG datasets. The pipeline includes an automatically generated report for each dataset processed. Users can download the PREP pipeline as a freely available MATLAB library from http://eegstudy.org/prepcode.

  20. Bridge technology report

    CERN Document Server

    2013-01-01

    Please note this is a Short Discount publication. As LANs have proliferated, new technologies and system concepts have come to the fore. One of the key issues is how to interconnect networks. One means of interconnection is to use a 'bridge'. Other competing technologies are repeaters, routers, and gateways. Bridges permit traffic isolation, connect network segments together and operate at the MAC layer. Further, because they operate at the MAC layer, they can handle a variety of protocols such as TCP/IP, SNA, and X.25. This report focuses on the specific technology of bridging two netw

  1. Evaluative Assessment for NASA/GSFC Equal Opportunity Programs Office Sponsored Programs

    Science.gov (United States)

    Jarrell, H. Judith

    1995-01-01

    The purpose of PREP (Pre-College Minority Engineering Program) is to upgrade skills of minority students who have shown an interest in pursuing academic degrees in electrical engineering. The goal is to upgrade skills needed for successful completion of the rigorous curriculum leading to a Bachelor of Science degree in engineering through a comprehensive upgrade of academic, study and interpersonal skills.

  2. Bridges analysis, design, structural health monitoring, and rehabilitation

    CERN Document Server

    Bakht, Baidar

    2015-01-01

    This book offers a valuable guide for practicing bridge engineers and graduate students in structural engineering; its main purpose is to present the latest concepts in bridge engineering in fairly easy-to-follow terms. The book provides details of easy-to-use computer programs for: ·      Analysing slab-on-girder bridges for live load distribution. ·      Analysing slab and other solid bridge components for live load distribution. ·      Analysing and designing concrete deck slab overhangs of girder bridges under vehicular loads. ·      Determining the failure loads of concrete deck slabs of girder bridges under concentrated wheel loads. In addition, the book includes extensive chapters dealing with the design of wood bridges and soil-steel bridges. Further, a unique chapter on structural health monitoring (SHM) will help bridge engineers determine the actual load carrying capacities of bridges, as opposed to their perceived analytical capacities. The chapter addressing structures...

  3. Detection of Subsurface Defects in Concrete Bridge Deck Joints

    Directory of Open Access Journals (Sweden)

    Wonchang Choi

    2011-01-01

    Full Text Available Problem statement: The integrity of deck joints in highway bridges plays a major role to determine overall performance of bridge system. As the bridge maintenance program, the defects in deck joints have historically been detected by conventional non-destructive testing and evaluation methods such as visual inspection, chain-dragging and by the detecting sounds under the traffic. Future bridge maintenance challenges will demand the development of techniques and procedures to detect and monitor such defects before they become apparent. Approach: Two non-destructive methods; namely Ground Penetration Radar (GPR and Seismic Properties Analyzer (SPA were employed to assess the integrity of deck joins installed in North Carolina bridges. Results: The results obtained with the GPR and SPA allows to quantify the subsurface defects in bridge deck joints. Conclusion: The practical application and limitations of each method are discussed in this study.

  4. 77 FR 10542 - Revision of the National Preparedness for Response Exercise Program (PREP) Guidelines

    Science.gov (United States)

    2012-02-22

    ... Federal Register (73 FR 3316). Public meeting: After considering public comments and developing a revised... the Coast Guard's Salvage and Marine Firefighting regulations. We invite public comment on what..., Commercial Regulations and Standards U.S. Coast Guard. BILLING CODE 9110-04-P...

  5. Proliferation resistance design of a plutonium cycle (Proliferation Resistance Engineering Program: PREP)

    Energy Technology Data Exchange (ETDEWEB)

    Sorenson, R.J.; Roberts, F.P.; Clark, R.G.

    1979-01-19

    This document describes the proliferation resistance engineering concepts developed to counter the threat of proliferation of nuclear weapons in an International Fuel Service Center (IFSC). The basic elements of an International Fuel Service Center are described. Possible methods for resisting proliferation such as processing alternatives, close-coupling of facilities, process equipment layout, maintenance philosophy, process control, and process monitoring are discussed. Political and institutional issues in providing proliferation resistance for an International Fuel Service Center are analyzed. The conclusions drawn are (1) use-denial can provide time for international response in the event of a host nation takeover. Passive use-denial is more acceptable than active use-denial, and acceptability of active-denial concepts is highly dependent on sovereignty, energy dependence and economic considerations; (2) multinational presence can enhance proliferation resistance; and (3) use-denial must be nonprejudicial with balanced interests for governments and/or private corporations being served. Comparisons between an IFSC as a national facility, an IFSC with minimum multinational effect, and an IFSC with maximum multinational effect show incremental design costs to be less than 2% of total cost of the baseline non-PRE concept facility. The total equipment acquisition cost increment is estimated to be less than 2% of total baseline facility costs. Personnel costs are estimated to increase by less than 10% due to maximum international presence. 46 figures, 9 tables.

  6. Identifying hidden sexual bridging communities in Chicago.

    Science.gov (United States)

    Youm, Yoosik; Mackesy-Amiti, Mary Ellen; Williams, Chyvette T; Ouellet, Lawrence J

    2009-07-01

    Bridge populations can play a central role in the spread of human immunodeficiency virus (HIV) by providing transmission links between higher and lower prevalence populations. While social network methods are well suited to the study of bridge populations, analyses tend to focus on dyads (i.e., risk between drug and/or sex partners) and ignore bridges between distinct subpopulations. This study takes initial steps toward moving the analysis of sexual network linkages beyond individual and risk group levels to a community level in which Chicago's 77 community areas are examined as subpopulations for the purpose of identifying potential bridging communities. Of particular interest are "hidden" bridging communities; that is, areas with above-average levels of sexual ties with other areas but whose below-average AIDS prevalence may hide their potential importance for HIV prevention. Data for this analysis came from the first wave of recruiting at the Chicago Sexual Acquisition and Transmission of HIV Cooperative Agreement Program site. Between August 2005 through October 2006, respondent-driven sampling was used to recruit users of heroin, cocaine, or methamphetamine, men who have sex with men regardless of drug use, the sex partners of these two groups, and sex partners of the sex partners. In this cross-sectional study of the sexual transmission of HIV, participants completed a network-focused computer-assisted self-administered interview, which included questions about the geographic locations of sexual contacts with up to six recent partners. Bridging scores for each area were determined using a matrix representing Chicago's 77 community areas and were assessed using two measures: non-redundant ties and flow betweenness. Bridging measures and acquired immunodeficiency syndrome (AIDS) case prevalence rates were plotted for each community area on charts representing four conditions: below-average bridging and AIDS prevalence, below-average bridging and above

  7. Bridging Humanism and Behaviorism.

    Science.gov (United States)

    Chu, Lily

    1980-01-01

    Humanistic behaviorism may provide the necessary bridge between behaviorism and humanism. Perhaps the most humanistic approach to teaching is to learn how certain changes will help students and how these changes can be accomplished. (Author/MLF)

  8. State's First Bridge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Article with details on the state's first bridge that crossed the Noxubee River adjacent to the Noxubee National Wildlife Refuge Boundary. Details also included...

  9. Bridged Race Population Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — Population estimates from "bridging" the 31 race categories used in Census 2000, as specified in the 1997 Office of Management and Budget (OMB) race and ethnicity...

  10. Cost-effectiveness of PrEP in HIV/AIDS control in Zambia: a stochastic league approach

    NARCIS (Netherlands)

    Nichols, B.E.; Baltussen, R.M.; Dijk, J.H. van; Thuma, P.E.; Nouwen, J.L.; Boucher, C.A.B.; Vijver, D.A. van de

    2014-01-01

    BACKGROUND: Earlier antiretroviral therapy initiation and pre-exposure prophylaxis (PrEP) prevent HIV, although at a substantial cost. We use mathematical modeling to compare the cost-effectiveness and economic affordability of antiretroviral-based prevention strategies in rural Macha, Zambia.

  11. Vulnerable infected populations and street markets for ARVs: Potential implications for PrEP rollout in the USA.

    Science.gov (United States)

    Kurtz, Steven P; Buttram, Mance E; Surratt, Hilary L

    2014-04-01

    Widespread diversion of antiretroviral (ARV) medications to illicit markets has recently been documented among indigent patients in South Florida. The recent approval of ARVs for pre-exposure prophylaxis (PrEP) has the potential to broaden these illicit markets, as high-risk individuals seek ARVs without a prescription or medical supervision. Nonadherence among diverters and unsupervised use of ARVs for treatment or PrEP increase risks of treatment failure, drug resistance, and disease transmission. We report the scope of ARV diversion among substance-using men who have sex with men in South Florida. Structured interviews (N = 515) queried demographics, HIV status, mental distress, substance dependence, and sexual risks. HIV-positive participants answered questions about medical care, treatment, and ARV adherence and diversion. Median age was 39. Of 46.4% who were HIV-positive, 79.1% were prescribed ARVs. Of these, 27% reported selling/trading ARVs. Reasons for diversion were sharing/trading with friends, sale/trade for money/drugs, and sale/trade of unused medications. ARV diverters, compared to nondiverters, were more likely to be substance dependent (74.5% vs. 58.7%, p = 0.046) and have traded sex for money/drugs (60.8% vs. 32.6%, p system. The implications of diversion for increased risks of treatment failure, disease transmission, and PrEP failure should be carefully considered in developing policy and behavioral supports to scaling up treatment as prevention and PrEP.

  12. Saying 'No' to PrEP research in Malawi: what constitutes 'failure' in offshored HIV prevention research?

    Science.gov (United States)

    Peterson, Kristin; Folayan, Morenike Oluwatoyin; Chigwedere, Edward; Nthete, Evaristo

    2015-12-01

    Between 2004 and 2005, the first multi-sited clinical trial tested whether an existing, marketed antiretroviral drug, Tenofovir (TDF), could prevent HIV transmission. Referred to as pre-exposure prophylaxis (PrEP), most of these trial sites prematurely closed down. Two sites located in Cambodia and Cameroon received international media attention. But little attention was drawn to sites in Malawi and Nigeria, where university ethicists and research scientists extensively debated PrEP. This article focuses on events that took place in Malawi where there was a prolonged dispute over the scientific rationales of PrEP and not trial specific ethics referred to as 'bioethics'. Specifically, the article discusses debates pertaining to three PrEP trial protocols that were refused ethics approval in Malawi between 2004 and 2009. It is argued that HIV science debates in Malawi are embedded in postcolonial politics--geopolitical histories and state and household economic dispossessions that have created the structural possibilities for Malawi to become an offshore destination for HIV clinical research. As such, ethics in this case does not pertain to trial or bioethical 'failures'. Rather, ethics is located at the scale of imperial relations that give rise to multiple, often invisible, research concerns and constraints.

  13. Germ Cell Intercellular Bridges

    Science.gov (United States)

    Greenbaum, Michael P.; Iwamori, Tokuko; Buchold, Gregory M.; Matzuk, Martin M.

    2011-01-01

    Stable intercellular bridges are a conserved feature of gametogenesis in multicellular animals observed more than 100 years ago, but their function was unknown. Many of the components necessary for this structure have been identified through the study of cytokinesis in Drosophila; however, mammalian intercellular bridges have distinct properties from those of insects. Mammalian germ cell intercellular bridges are composed of general cytokinesis components with additional germ cell–specific factors including TEX14. TEX14 is an inactive kinase essential for the maintenance of stable intercellular bridges in gametes of both sexes but whose loss specifically impairs male meiosis. TEX14 acts to impede the terminal steps of abscission by competing for essential component CEP55, blocking its interaction in nongerm cells with ALIX and TSG101. Additionally, TEX14-interacting protein RBM44, whose localization in stabile intercellular bridges is limited to pachytene and secondary spermatocytes, may participate in processes such as RNA transport but is nonessential to the maintenance of intercellular bridge stability. PMID:21669984

  14. Long Span Bridges in Scandinavia

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1998-01-01

    The first Scandinavian bridge with a span of more than 500 m was the Lillebælt Suspension Bridge opened to traffic in 1970.Art the end of the 20th century the longest span of any European bridge is found in the Storebælt East Bridge with a main span of 1624 m. Also the third longest span in Europe...... is found in Scandinavia - the 1210 m span of the Höga Kusten Bridge in Sweden.The Kvarnsund Bridge in Norway was at the completion in 1991 the longest cable-stayed bridge in the world, and the span of 530 m is still thge longest for cable-stayed bridges in concrete. The Øresund Bridge with its sapn of 490...... m is the longest among cable-stayed bridges for both road and railway traffic....

  15. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP in clinical settings to prevent HIV infection.

    Directory of Open Access Journals (Sweden)

    Emily A Arnold

    Full Text Available BACKGROUND: A recent clinical trial demonstrated that a daily dose tenofovir disoproxil fumarate and emtricitabrine (TDF-FTC can reduce HIV acquisition among men who have sex with men (MSM and transgender (TG women by 44%, and up to 90% if taken daily. We explored how medical and service providers understand research results and plan to develop clinical protocols to prescribe, support and monitor adherence for patients on PrEP in the United States. METHODS: Using referrals from our community collaborators and snowball sampling, we recruited 22 healthcare providers in San Francisco, Oakland, and Los Angeles for in-depth interviews from May-December 2011. The providers included primary care physicians seeing high numbers of MSM and TG women, HIV specialists, community health clinic providers, and public health officials. We analyzed interviews thematically to produce recommendations for setting policy around implementing PrEP. Interview topics included: assessing clinician impressions of PrEP and CDC guidance, considerations of cost, office capacity, dosing schedules, and following patients over time. RESULTS: Little or no demand for PrEP from patients was reported at the time of the interviews. Providers did not agree on the most appropriate patients for PrEP and believed that current models of care, which do not involve routine frequent office visits, were not well suited for prescribing PrEP. Providers detailed the need to build capacity and were concerned about monitoring side effects and adherence. PrEP was seen as potentially having impact on the epidemic but providers also noted that community education campaigns needed to be tailored to effectively reach specific vulnerable populations. CONCLUSIONS: While PrEP may be a novel and clinically compelling prevention intervention for MSM and TG women, it raises a number of important implementation challenges that would need to be addressed. Nonetheless, most providers expressed optimism that

  16. Introduction of the Thin Prep Imaging System™ (TIS: experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-02-01

    Full Text Available Abstract Objective Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women's Hospital. We introduced the TIS in December 2004. Methods The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003–November 2004 are taken as the historic control group for our study. Results The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022. The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  17. Willingness to use pre-exposure prophylaxis (PrEP for HIV prevention among men who have sex with men (MSM in Malaysia: findings from a qualitative study

    Directory of Open Access Journals (Sweden)

    Adam Bourne

    2017-01-01

    Conclusions: This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those taking it may be stigmatized, it is crucial that the use of PrEP is presented as a responsible course of action, and one of a range of strategies that men can use to keep themselves safe from HIV.

  18. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers

    Directory of Open Access Journals (Sweden)

    Arcelino Farias-Neto

    2015-01-01

    Full Text Available Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  19. Esthetic Rehabilitation of the Smile with No-Prep Porcelain Laminates and Partial Veneers.

    Science.gov (United States)

    Farias-Neto, Arcelino; Gomes, Edna Maria da Cunha Ferreira; Sánchez-Ayala, Alfonso; Sánchez-Ayala, Alejandro; Vilanova, Larissa Soares Reis

    2015-01-01

    Rehabilitation of patients with anterior conoid teeth may present a challenge for the clinician, especially when trying to mimic the nature with composite resins. This clinical report exemplifies how a patient with conoid upper lateral incisors was rehabilitated with minimally invasive adhesive restorations. Following diagnostic wax-up and cosmetic mock-up, no-prep veneers and ceramic fragments (partial veneers) were constructed with feldspathic porcelain. This restorative material presents excellent reproduction of the optical properties of the dental structure, especially at minimal thicknesses. In this paper, the details about the treatment are described. A very pleasing outcome was achieved, confirming that minimally invasive adhesive restorations are an excellent option for situations in which the dental elements are healthy, and can be modified exclusively by adding material and the patient does not want to suffer any wear on the teeth.

  20. Mars Atmosphere and Volatile EvolutioN (MAVEN) mission's Red Planet program: Bridging the gap in elementary school science through climate studies of Mars

    Science.gov (United States)

    Wood, E. L.

    2012-12-01

    Although reading, writing, and math examinations are often conducted early in elementary school, science is not typically tested until 4th or 5th grade. The result is a refocus on the tested topics at the expense of the untested ones, despite that standards exist for each topic at all grades. On a national level, science instruction is relegated to a matter of a few hours per week. A 2007 Education Policy study states that elementary school students spend an average of 178 minutes a week on science while spending 500 minutes on literacy. A recent NSTA report in July of 2011 of elementary and middle school teachers confirms that teachers feel pressured to teach math and literacy at the expense of other programs. In our interaction with elementary teachers, it is also apparent that many are uncomfortable with science concepts. In order for us to successfully address the Next Generation Science Standards, teachers must be able to reconcile all of the different requirements placed on them in a given school day and in a given school environment. A unique way to combat the lack of science instruction at elementary grades is to combine literacy into an integrated science program, thereby increasing the number of science contact hours. The Red Planet: Read, Write, Explore program, developed for the MAVEN mission, is a science, art, and literacy program designed to easily fit into a typical 3rd-5th grade instructional day. Red Planet tackles climate change through Mars' geologic history and makes Mars-Earth comparisons, while encouraging students to reflect on the environmental requirements needed to keep a biological organisms (including humans) happy, healthy, and alive. The Red Planet program is currently being pilot tested at Acres Green Elementary School in Colorado.

  1. Lecture to inquiry: The transformation of a tech prep biology teacher

    Science.gov (United States)

    Haskell, Deborah Harris

    As teachers implement the National Science Education Standards (NRC, 1996) many have to reform the instructional methods they have used throughout their careers. This case study examines the transformation of Laurie, a 20-year teacher, during her first year of change from a "traditional" textbook/lecture style of teaching to a facilitator of an inquiry-based classroom. Implementing change requires not only pedagogical expertise, but also the belief that the modifications can be made and that the outcomes are significant. Using Bandura's social cognitive theory as a framework, changes in Laurie's self-efficacy, outcome expectancy, and motivation are followed throughout the transition. During her first year of change, Laurie used worksheets, small group activities, and guided inquiry activities, all strategies in which she had high self-efficacy and experienced positive student outcomes. She rarely used class forums, authentic assessment, and formative assessment. Factors that influenced her change were experiential professional development opportunities that allowed her to practice inquiry-based techniques, a change in her teaching environment from college prep chemistry to tech prep biology, autonomy regarding classroom decisions, and reflective decision making as she learned through experience. Using a standards-based biology textbook increased her self-efficacy toward using inquiry-based practices. The textbook format of embedding text in activities rather than adding activities to the text resulted in an increase of the number and frequency of activities done. Facilitating the textbook's Guided Inquiries and Extended Inquiries helped Laurie gain experience with inquiry-based methods. She also realized that when building from the students' concrete experiences, her students were able to attain higher-level thinking skills. The study revealed six factors contributing to Laurie's change process: (a) experiential professional development, (b) motivation for change

  2. Who should be offered HIV pre-exposure prophylaxis (PrEP)?: A secondary analysis of a Phase 3 PrEP efficacy trial in men who have sex with men and transgender women

    Science.gov (United States)

    Buchbinder, Susan P; Glidden, David V.; Liu, Albert Y.; McMahan, Vanessa; Guanira, Juan V.; Mayer, Kenneth H.; Goicochea, Pedro; Grant, Robert M.

    2014-01-01

    Background Pre-exposure prophylaxis (PrEP) has been proven to reduce HIV acquisition in men who have sex with men and transgender women (MSM/TGW). For maximal impact, PrEP should be targeted to subpopulations accounting for the largest proportion of infections (population attributable fraction, PAF) and for whom the number needed to treat (NNT) to prevent infection is lowest. Methods The iPrEx study was a randomized controlled efficacy trial of tenofovir-disoproxil-fumarate/emtricitabine PrEP in 2499 MSM/TGW on 4 continents. We calculated the association between demographic and risk behavior during screening with subsequent seroconversion among placebo recipients using a Poisson model, and the PAF and NNT for risk behavior subgroups. Findings Of 1248 placebo participants enrolled, 83 became HIV infected in follow-up. Participants reporting non-condom receptive anal intercourse (ncRAI) seroconverted significantly more often than MSM/TGW reporting no condomless anal sex (adjusted hazard ratio (AHR) 5·11, 95% CI 1·55-16·79). The overall PAF for MSM/TGW reporting ncRAI was 64% (prevalence=60%). Most of this risk came from ncRAI with unknown serostatus partners (PAF 53%, prevalence=54%, AHR 4·76); in contrast, the PAF for ncRAI with an HIV positive partner, an uncommon practice, was only 1% (prevalence 1%, AHR=7·11). The overall NNT per year for the cohort was 62 (95% CI 44-147). NNTs were lower for MSM/TGW self-reporting ncRAI, cocaine use, or a sexually transmitted infection (NNT= 36, 12, and 41 respectively). Having a single partner or non-condom insertive anal sex had the highest NNTs. Interpretation PrEP may be most effective at a population level if targeted toward MSM/TGW reporting ncRAI, even with partners perceived to be HIV negative. Substance use history and testing for STIs may also inform individual decisions to start PrEP. Considering PAF and NNT can aid in discussing the benefits and risks of PrEP with MSM/TGW. Funding Funded by the National

  3. Optimization Analysis of Stayed-buckle Cable Forces of a Oversized Bridge Construction Based on the Linear Programming%基于线性规划的某特大桥施工扣索索力优选分析

    Institute of Scientific and Technical Information of China (English)

    张耀庭; 颜燕祥; 张正哲; 李艳芳; 张敏

    2014-01-01

    With the development of the large-span bridge engineering, the affirmance of the wire rope cable forces of the connection between the bridge superstructure and piers ( Abutment) has become a key technical problem in bridge design and construction process. The design of cable force is directly related to safety issues and the normal use in the construction and operational stage. Combined with the construction of a Bridge,the article presents the principle of linear programming to optimize cable force. The optimal method of cable force uses the cable dosage minimum as an objective function and the pre-tension force as optimal variables, and then uses the stress in key sections and the deflection in end of cantilever as constraint conditions. With the help of ANSYS software and MATLAB tools,the optimization of construction ( temporary) buckle cable tension of stage of the structure of linear work is achieved. Compared with the existing cable force methods, the method proposed in this paper to determine cable force can reduce the number of tune cable construction process and improve the accuracy of the design of cable force. For similar projects, it provides a new way of thinking to determine the steel cables of the relative optimum tensile force.%随着斜拉桥等大跨度桥梁工程的发展,桥梁上部结构与桥墩(台)之间连接的钢索索力的确定已成为桥梁设计与施工过程中的关键技术问题,索力取值合理与否直接关系到结构施工及运营阶段的安全与正常使用问题。本文结合某特大桥的施工,将线性规划原理引入到该桥的施工索力优化当中,以扣索用量最少为目标函数,以拉索索力大小为控制变量,以关键截面应力和悬臂端点挠度为约束条件;借助ANSYS软件和MATLAB工具,实现了结构线性工作阶段的施工(临时)扣索索力的优选分析。与已有的索力确定方法相比,本文提出的确定索力方法可减少施工过程

  4. Bridging the Participation Gap with Government-sponsored Neighborhood Development Programs: Can Civic Skills Be Taught? El Uso de Programas de Desarrollo Social para Fomentar el Civismo

    Directory of Open Access Journals (Sweden)

    Katsuo A. Nishikawa

    2012-01-01

    Full Text Available I argue that innovative development programs that require citizen participation in the production of public goods can have unexpected bene-fits for individuals’ dispositions toward democracy. In particular, I explore the effect of taking part in state-sponsored neighborhood development programs – direct-democracy type programs that require individuals to organize within their community as a precondition for state help – on participant dispositions toward democracy and willingness to take part in politics. To test this hypothesis, I use original survey data collected in the Mexican state of Baja California. To measure the effect of participation in neighborhood development programs, I conduct a quasi experiment via propensity score matching. I find robust evidence suggesting that participating in such programs correlates with higher levels of political participation, a better sense of community, more positive retrospective evaluations of the economy (according to both pocketbook and sociotropic measures, and overall higher support for the government.En este estudio, propongo que programas innovadores de desarrollo social que requieren de la participación ciudadana para crear bienes públicos pueden, inesperadamente, fomentar actitudes favorables para la democracia. Específicamente, analizo como las disposiciones democráticas y el interés por participar en la vida política de sus comunidades cambia entre beneficiarios y no beneficiarios del programa. Dicho programa posee un estilo de democracia directa, en donde se requiere que los beneficiarios se organicen a nivel colonia como condición de implementación del programa. Para probar esta hipótesis, realicé una encuesta en el estado de Baja California, México. Para medir el efecto de participación en programas de desarrollo social, hice uso del método estadístico conocido en inglés como “propensity score matching” para llevar a cabo un cuasi experimento. Al final, encuentro

  5. The aesthetic composite bridge.

    Science.gov (United States)

    Feinman, R A

    1997-01-01

    New developments are constantly introduced in the search for the optimal treatment modality to restore a single anterior tooth. The patient attention has shifted to aesthetics of the restoration, biocompatibility of the dental materials utilized, conservative preparation of the teeth to be restored, and the retention of intact adjacent dentition. The learning objective of this article is to review the methods currently utilized and to present a recently introduced treatment modality--the two-component bridge, which combines the strength and resiliency of composite resin with the aesthetic advantages of porcelain. The technology of the material is reviewed, the predominantly lingual tooth preparation procedures are outlined, and the bridge try-in is described. The advantages of the two-component bridge are presented along with the contraindications and suggestions of careful case selection. Three cases with congenitally missing maxillary lateral incisors in youthful patients are presented to supplement the theoretical outline and to describe and illustrate the clinical procedure.

  6. Istanbul Bridge Conference 2014

    CERN Document Server

    Gülkan, Polat; Mahmoud, Khaled

    2016-01-01

      The book includes peer-reviewed contributions selected from presentations given at the Istanbul Bridge Conference 2014, held from August 11 – 13 in Istanbul, Turkey. It reports on the current challenges in bridge engineering faced by professionals around the globe, giving a special emphasis to recently developed techniques, innovations and opportunities. The book covers key topics in the field, including modeling and analysis methods; construction and erection techniques; design for extreme events and condition assessment and structural health monitoring. There is a balanced presentation of theory, research and practice. This book, which provides the readers with a comprehensive and timely reference guide on current practices in bridge engineering, is intended for professionals, academic researchers and students alike.

  7. Active Control of Suspension Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper some recent research on active control of very long suspension bridges, is presented. The presentation is based on research work at Aalborg University, Denmark. The active control system is based on movable flaps attached to the bridge girder. Wind load on bridges with or without...... flaps attached to the girder is briefly presented. A simple active control system is discussed. Results from wind tunnel experiments with a bridge section show that flaps can be used effectively to control bridge girder vibrations. Flutter conditions for suspension bridges with and without flaps...

  8. GE Smart Prep半自动监控软件的应用要点%Application Keypoints of GE Light Speed 8 Smart Prep Semiautomatic Monitoring Software

    Institute of Scientific and Technical Information of China (English)

    肖建明

    2011-01-01

    目的 探讨GE light speed 8 smart Prep技术在CT血管造影中的准确应用.方法 采用GE light speed 8 Smart Pmp软件对35例患者进行颅脑CTA检查.结果 总结出GE light speed 8运用smart prep 的技术要点.%Objective To investigate the application of the GE light speed 8 smart prep technique in CT angiography. Methods Used GE light speed 8 Smart Prep software to assist the check of cerebral CTA in 35 patients. Results Summarized the application keypoints of CE light speed 8 smart prep technique.

  9. Prevalence and characteristics of users of pre-exposure prophylaxis (PrEP) among men who have sex with men, San Francisco, 2014 in a cross-sectional survey: implications for disparities.

    Science.gov (United States)

    Snowden, Jonathan M; Chen, Yea-Hung; McFarland, Willi; Raymond, Henry F

    2017-02-01

    Pre-exposure prophylaxis (PrEP) has gained a central role in prevention of HIV infection among men who have sex with men (MSM), particularly in San Francisco, California, USA. Programmes to enrol men in PrEP are being undertaken by a range of public and private organisations. PrEP will have the largest population impact if it reaches men who are most at risk for HIV infection, and is used in a manner that enables maximal efficacy. Access to PrEP also needs to be equitable. We report on the characteristics of men eligible for and using PrEP. Data were from the 2014 implementation of National HIV Behavioural Surveillance (NHBS) among MSM in San Francisco. NHBS uses venue-based sampling as the national standard for sampling MSM. We compare proportions of demographic characteristics of MSM using versus not using PrEP who are HIV-negative and meet Centers for Disease Control and Prevention guidelines to recommend PrEP. Overall, 64.1% of HIV-negative MSM in San Francisco would meet guidelines for PrEP use, while 9.2% of MSM overall and 14.5% of MSM eligible were using PrEP as of 2014. Men using PrEP are more likely to be white and of older age. There were no differences between men using and not using PrEP in terms of education, income and health insurance. PrEP roll-out efforts should attempt to increase reach for young, black and Hispanic MSM. Failure to equitably provide access to PrEP could exacerbate the US disparity in new HIV infections for men of colour. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. Pre-exposure Prophylaxis (PrEP) Use, Seroadaptation, and Sexual Behavior Among Men Who Have Sex with Men, San Francisco, 2004-2014.

    Science.gov (United States)

    Chen, Yea-Hung; Snowden, Jonathan M; McFarland, Willi; Raymond, H Fisher

    2016-12-01

    The Food and Drug Administration approved pre-exposure prophylaxis (PrEP) to prevent HIV infection, and the Centers for Disease Control and Prevention has presented PrEP as a prevention option for groups at high risk such as men who have sex with men (MSM). Intervention data provide some information on how PrEP affects sexual behavior of MSM in trials, open label extensions, or clinics. However, it is unclear whether sexual risk and preventive behavioral patterns are changing in the population as a whole as PrEP becomes more widely available, whether due to PrEP use or other factors. We examined trends in PrEP use, numbers of condomless anal sex partners, consistent condom use, and seroadaptive strategies in San Francisco-a city which has actively promoted PrEP-using data from National HIV Behavioral Surveillance (NHBS). NHBS recruited 1211, 383, 373, and 268 HIV-negative MSM in 2004, 2008, 2011, and 2014, respectively. PrEP use increased from zero in 2004, 2008, and 2011 to 9.6 % in 2014. The proportion of men with no condomless anal sex partners dropped from 60.6 % in 2004, to 58.2 % in 2008, to 54.2 % in 2011, to 40.2 % in 2014. Consistent condom use decreased from 36.8 % in 2004, and 30.5 % in 2008 and 2011, to 18.3 % in 2014. PrEP's introduction and scale-up enters in a pre-existing trend of decreasing condom use and increasing sexually transmitted infections among MSM which may be accelerating in recent years. While PrEP use should be scaled up as a prevention option among those who would benefit most, we believe that public health officials need to be realistic about the possibility that condom use could very well continue to decline as PrEP use increases, and to an extent that may not be directly or indirectly offset by PrEP.

  11. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    OpenAIRE

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R. (Rainer); Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D; Rouzioux, C

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  12. Evaluation of an Upgraded Version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test for HIV-1 Load Quantification▿

    Science.gov (United States)

    Damond, F.; Avettand-Fenoel, V.; Collin, G.; Roquebert, B.; Plantier, J. C.; Ganon, A.; Sizmann, D.; Babiel, R.; Glaubitz, J.; Chaix, M. L.; Brun-Vezinet, F.; Descamps, D.; Rouzioux, C.

    2010-01-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated. PMID:20129964

  13. Evaluation of an upgraded version of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test for HIV-1 load quantification.

    Science.gov (United States)

    Damond, F; Avettand-Fenoel, V; Collin, G; Roquebert, B; Plantier, J C; Ganon, A; Sizmann, D; Babiel, R; Glaubitz, J; Chaix, M L; Brun-Vezinet, F; Descamps, D; Rouzioux, C

    2010-04-01

    We evaluated the performance of the prototype Cobas AmpliPrep/Cobas TaqMan HIV-1 test, version 2.0, using prospective and archived clinical samples initially underquantitated by the Cobas AmpliPrep/Cobas TaqMan HIV-1 test. The performance of the new test was significantly improved, and the majority of the underquantitation observed with the first-version test was eliminated.

  14. When are declines in condom use while using PrEP a concern? Modelling insights from a Hillbrow, South Africa case study

    Directory of Open Access Journals (Sweden)

    Hannah Grant

    2017-01-01

    Full Text Available Introduction: Oral pre-exposure prophylaxis (PrEP is a promising new prevention approach for those most at risk of HIV infection. However, there are concerns that behavioural disinhibition, specifically reductions in condom use, might limit PrEP’s protective effect. This study uses the case of female sex workers (FSWs in Johannesburg, South Africa, to assess whether decreased levels of condom use following the introduction of PrEP may limit HIV risk reduction.Methods: We developed a static model of HIV risk and compared HIV-risk estimates before and after the introduction of PrEP to determine the maximum tolerated reductions in condom use with regular partners and clients for HIV risk not to change. The model incorporated the effects of increased STI exposure owing to decreased condom use. Noting that condom use with regular partners is generally low, we also estimated the change in condom use tolerated with clients only, to still achieve 50 and 90% risk reduction on PrEP. The model was parameterized using data from Hillbrow, Johannesburg. Sensitivity analyses were performed to ascertain the robustness of our results.Results: Reductions in condom use could be tolerated by FSWs with lower baseline condom use (65%. For scenarios where 75% PrEP effectiveness is attained, 50% HIV-risk reduction on PrEP would be possible even with 100% reduction in condom use from consistent condom use as high as 70% with clients. Increased exposure to STIs through reductions in condom use had limited effect on the reductions in condom use tolerated for HIV risk not to increase on PrEP.Conclusions: PrEP is likely to be of benefit in reducing HIV risk, even if reductions in condom use do occur. Efforts to promote consistent condom use will be critical for FSWs with high initial levels of condom use, but with challenges in adhering to PrEP.

  15. Comparing the impact of increasing condom use or HIV pre-exposure prophylaxis (PrEP use among female sex workers

    Directory of Open Access Journals (Sweden)

    Zindoga Mukandavire

    2016-03-01

    Full Text Available In many settings, interventions targeting female sex workers (FSWs could significantly reduce the overall transmission of HIV. To understand the role HIV pre-exposure prophylaxis (PrEP could play in controlling HIV transmission amongst FSWs, it is important to understand how its impact compares with scaling-up condom use—one of the proven HIV prevention strategies for FSWs. It is important to remember that condoms also have other benefits such as reducing the incidence of sexually transmitted infections and preventing pregnancy. A dynamic deterministic model of HIV transmission amongst FSWs, their clients and other male partners (termed ‘pimps’ was used to compare the protection provided by PrEP for HIV-negative FSWs with FSWs increasing their condom use with clients and/or pimps. For different HIV prevalence scenarios, levels of pimp interaction, and baseline condom use, we estimated the coverage of PrEP that gives the same reduction in endemic FSW HIV prevalence or HIV infections averted as different increases in condom use. To achieve the same impact on FSW HIV prevalence as increasing condom use by 1%, the coverage of PrEP has to increase by >2%. The relative impact of PrEP increases for scenarios where pimps contribute to HIV transmission, but not greatly, and decreases with higher baseline condom use. In terms of HIV infections averted over 10 years, the relative impact of PrEP compared to condoms was reduced, with a >3% increase in PrEP coverage achieving the same impact as a 1% increase in condom use. Condom promotion interventions should remain the mainstay HIV prevention strategy for FSWs, with PrEP only being implemented once condom interventions have been maximised or to fill prevention gaps where condoms cannot be used.

  16. Computation simulation of the nonlinear response of suspension bridges

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, D.B.; Astaneh-Asl, A.

    1997-10-01

    Accurate computational simulation of the dynamic response of long- span bridges presents one of the greatest challenges facing the earthquake engineering community The size of these structures, in terms of physical dimensions and number of main load bearing members, makes computational simulation of transient response an arduous task. Discretization of a large bridge with general purpose finite element software often results in a computational model of such size that excessive computational effort is required for three dimensional nonlinear analyses. The aim of the current study was the development of efficient, computationally based methodologies for the nonlinear analysis of cable supported bridge systems which would allow accurate characterization of a bridge with a relatively small number of degrees of freedom. This work has lead to the development of a special purpose software program for the nonlinear analysis of cable supported bridges and the methodologies and software are described and illustrated in this paper.

  17. Willingness to use short-term oral pre-exposure prophylaxis (PrEP) by migrant miners and female partners of migrant miners in Mozambique.

    Science.gov (United States)

    Falcao, Joana; Ahoua, Laurence; Zerbe, Allison; di Mattei, Pietro; Baggaley, Rachel; Chivurre, Victor; Mulondo, Prince; Ramiro, Isaias; Dalal, Shona; Morales, Fernando; O'Reilly, Kevin; El-Sadr, Wafaa

    2017-05-04

    Migrant miners from Mozambique who work in South Africa and their partners are at substantial risk for HIV infection. We conducted a cross-sectional study to assess the willingness of migrant miners and female partners of miners to take short-term pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition. The study was conducted in Gaza Province, Mozambique, between September and October 2015. A total of 131 male miners and female partners of male miners completed a questionnaire. Subsequently, 48 in-depth interviews among male miners and female partners of miners and 3 focus-group discussions (6 participants each) among female partners of miners were conducted. Quantitative data were tabulated using Stata. A structured coding scheme was developed and qualitative data were analysed using Atlas.ti. Most participants (94%) were willing to take PrEP for short-term use. Facilitating factors for willingness to use PrEP were concerns about partner's sexual behaviour, desire for pregnancy and one's own sexual behaviour. The main barriers to PrEP use were concerns regarding side-effects, perceived difficulty adhering to daily pill taking and concern about partner/family disapproval. Overall, participants saw potential barriers for PrEP as minor obstacles that could be overcome. The male partner's influence on PrEP use was significant.

  18. Existing Steel Railway Bridges Evaluation

    Science.gov (United States)

    Vičan, Josef; Gocál, Jozef; Odrobiňák, Jaroslav; Koteš, Peter

    2016-12-01

    The article describes general principles and basis of evaluation of existing railway bridges based on the concept of load-carrying capacity determination. Compared to the design of a new bridge, the modified reliability level for existing bridges evaluation should be considered due to implementation of the additional data related to bridge condition and behaviour obtained from regular inspections. Based on those data respecting the bridge remaining lifetime, a modification of partial safety factors for actions and materials could be respected in the bridge evaluation process. A great attention is also paid to the specific problems of determination of load-caring capacity of steel railway bridges in service. Recommendation for global analysis and methodology for existing steel bridge superstructure load-carrying capacity determination are described too.

  19. BUILDING "BRIDGES" WITH QUALITY ASSURANCE

    Science.gov (United States)

    The papr describes how, rather than building "bridges" across centuries, quality assurance (QA) personnel have the opportunity to build bridges across technical disciplines, between public and private organizations, and between different QA groups. As reviewers and auditors of a...

  20. Bridging a Cultural Gap

    Science.gov (United States)

    Leviatan, Talma

    2008-01-01

    There has been a broad wave of change in tertiary calculus courses in the past decade. However, the much-needed change in tertiary pre-calculus programmes--aimed at bridging the gap between high-school mathematics and tertiary mathematics--is happening at a far slower pace. Following a discussion on the nature of the gap and the objectives of a…

  1. Building a Straw Bridge

    Science.gov (United States)

    Teaching Science, 2015

    2015-01-01

    This project is for a team of students (groups of two or three are ideal) to design and construct a model of a single-span bridge, using plastic drinking straws as the building material. All steps of the design, construction, testing and critiquing stages should be recorded by students in a journal. Students may like to include labelled diagrams,…

  2. DOE Information Bridge

    CERN Document Server

    United States. Department of Energy. Office of Scientific and Technical Information

    DOE Information Bridge, a component of EnergyFiles, provides free, convenient, and quick access to full-text DOE research and development reports in physics, chemistry, materials, biology, environmental sciences, energy technologies, engineering, computer and information science, renewable energy, and other topics. This vast collection includes over 43,000 reports that have been received and processed by OSTI since January 1995.

  3. Bridge over troubled water?

    DEFF Research Database (Denmark)

    Svendsen, Gunnar Lind Haase; Nannestad, Peter; Svendsen, Gert Tinggaard

    2008-01-01

    The problem of integrating non-Western immigrants into Western welfare states is the focus of this paper. To address this issue, we suggest a social capital approach in which we apply the conceptual pair of bridging social capital (BR), which connects an individual to the broader social structure...

  4. Looking Beyond the Bridge

    DEFF Research Database (Denmark)

    Jahn, Elke; Rosholm, Michael

    We perform a comprehensive analysis of the stepping-stone effect of temporary agency employment on unemployed workers. Using the timing-of-events approach, we not only investigate whether agency employment is a bridge into regular employment but also analyze its effect on post-unemployment wages...

  5. Bridging the Technological Gap.

    Science.gov (United States)

    Lazow, Robert; And Others

    The aim of "Bridging the Technological Gap" (BTG), a federally funded demonstration project, is to use microcomputer technology in the rehabilitation of the psychiatrically disabled. Through the use of a custom designed microcomputer software package, clients receive remediation in areas of specific cognitive and behavioral deficits. The project…

  6. Building Bridges to China.

    Science.gov (United States)

    Wasta, Stephanie; Scott, Margaret

    1998-01-01

    Describes a theme cycle called "Building Bridges to China" developed for third grade students that focuses on the similarities between the lives of children and families in China and the United States. Explains that the theme cycle addresses the National Geography Standards and three of the National Council for the Social Studies standards. (CMK)

  7. Partial-prep bonded restorations in the anterior dentition: Long-term gingival health and predictability. A case report.

    Science.gov (United States)

    Molina, Ivan Contreras; Molina, Gil Contreras; Stanley, Kyle; Lago, Carlo; Xavier, Clessius Ferreira; Volpato, Claudia Angela Maziero

    2016-01-01

    Bonded porcelain restorations are a predictable and durable treatment option that can restore not only the strength and function of the teeth but also the esthetic appearance. One important issue in adhesive dentistry is the preservation of sound enamel. Following biomimetic principles, employing minimally invasive applications and adhesive technologies is of paramount importance for successful restorations. While it is widely accepted that minimally invasive restorative techniques should be favored, there is still some controversy over the noninvasive approaches. The purpose of this article is to question the complete "no-prep veneer" concept due to the possible negative effects on periodontal health caused by excessive contour and overhangs of the ceramic restoration, and to propose a new method to assess the quality and longevity of veneers with a partial-prep concept.

  8. Revised Rules for Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Jensen, F. M.; Middleton, C.;

    This paper is based on research performed for the Highway Agency, London, UK under the project DPU/9/44 "Revision of Bridge Assessment Rules Based on Whole Life Performance: Concrete Bridges" It contains details of a methodology which can be used to generate Whole Life (WL) reliability profiles....... These WL reliability profiles may be used to establish revised rules for Concrete Bridges....

  9. The Bridges of Taishun County

    Institute of Scientific and Technical Information of China (English)

    MaJianhe

    2003-01-01

    The American film The Bridges of Madison County captured the imagination of many Chinese moviegoers with its bittersweet love story and scenes of rustic covered bridges. But the U.S. can't lay sole claim to such spectacular rural sights:China has its own county worldrenowned for unforgettable bridges.

  10. Vibration analysis of medium and small span bridges subjected to mixed marshalling freight trains

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    It has been reported several times that train derailment occurs when mixed marshalling freight trains traverse bridges at high speeds in China.This study aims to explain this phenomenon numerically based on the train-bridge coupling vibration theory and its associated computer program.The train-bridge vibration characteristic is analyzed by a computer program when mixed marshalling freight trains traverse 32-meter-span prestressed concrete simple beam bridges.The mechanism that dynamic responses of the bridges are prominent and that empty trains are inclined to derail are derived from the dynamic responses analysis.The analysis indicates that the significant differences of axle loads between heavy vehicles and empty vehicles produce periodic forced loadings of large amplitudes.These periodic loadings cause severe vibration of bridges.In turn,severe vibration of the bridges produces intensive counteraction to empty vehicles.

  11. Dynamic Bridge Response for a Bridge-friendly Truck

    Directory of Open Access Journals (Sweden)

    V. Šmilauer

    2004-01-01

    Full Text Available A truck with controlled semi-active suspensions traversing a bridge is examined for benefits to the bridge structure. The original concept of a road-friendly truck was extended to a bridge-friendly vehicle, using the same optimization tools. A half-car model with two independently driven axles is coupled with simply supported bridges (beam, slab model with the span range from 5 m to 50 m. Surface profile of the bridge deck is either stochastic or in the shape of a bump or a pot in the mid-span. Numerical integration in the MATLAB/SIMULINK environment solves coupled dynamic equations of motion with optimized truck suspensions. The rear axle generates the prevailing load and to a great extent determines the bridge response. A significant decrease in contact road-tire forces is observed and the mid-span bridge deflections are on average smaller, when compared to commercial passive suspensions. 

  12. Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology

    DEFF Research Database (Denmark)

    Rozemeijer, Kirsten; Naber, Steffie K; Penning, Corine

    2017-01-01

    Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry...... of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Women with 5 924 474 normal screening samples (23 833 123 person years).Exposure Use of SurePath or ThinPrep versus conventional cytology as screening test.Main outcome measure 72 month cumulative incidence...... was 58.5 (95% confidence interval 54.6 to 62.7) per 100 000 normal conventional cytology samples, compared with 66.8 (56.7 to 78.7) for ThinPrep and 44.6 (37.8 to 52.6) for SurePath. Compared with conventional cytology, the hazard of invasive cancer was 19% lower (hazard ratio 0.81, 95% confidence...

  13. Willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in Malaysia: findings from a qualitative study.

    Science.gov (United States)

    Bourne, Adam; Cassolato, Matteo; Thuan Wei, Clayton Koh; Wang, Bangyuan; Pang, Joselyn; Lim, Sin How; Azwa, Iskandar; Yee, Ilias; Mburu, Gitau

    2017-08-02

    Men who have sex with men (MSM) continue to be disproportionately affected by HIV in Malaysia. Recent success has been observed within demonstration projects examining the efficacy of HIV pre-exposure prophylaxis (PrEP), an antiretroviral -based medication taken by HIV-negative men to prevent sero-conversion. In order for such promising findings to be translated in real-world settings, it is important to understand the acceptability of PrEP, including perceived barriers to access or uptake. As part of a larger mixed-methods study exploring acceptability and willingness to use PrEP among MSM in Malaysia, 19 men took part in audio-recorded focus group discussions hosted by a community-based HIV organization and facilitated by a trained researcher. Discussions focussed on awareness and potential information management, general perceptions of PrEP and potential motivations or barriers to the use of PrEP, including those at the personal, social, health system or structural level. Data were transcribed verbatim and underwent a detailed thematic analysis. Rather than perceiving PrEP as a replacement for condoms in terms of having safer sex, many participants viewed it as an additional layer protection, serving as a crucial barrier to infection on occasions where condom use was intended, but did not occur. It was also perceived as more valuable to "at-risk" men, such as those in HIV sero-discordant relationships or those with a higher number of sexual partners. Elements of discussion tended to suggest that some men taking PrEP may be subject to stigma from others, on the assumption they may be promiscuous or engage in high-risk sexual behaviours. This qualitative study indicates that, broadly speaking, PrEP may be acceptable to MSM in Malaysia. However, in order for its potential to be realized, and uptake achieved, educative interventions are required to inform the target population as to the efficacy and potential, positive impact of PrEP. Given concerns for how those

  14. Simulation of multivariate diffusion bridges

    DEFF Research Database (Denmark)

    Bladt, Mogens; Finch, Samuel; Sørensen, Michael

    We propose simple methods for multivariate diffusion bridge simulation, which plays a fundamental role in simulation-based likelihood and Bayesian inference for stochastic differential equations. By a novel application of classical coupling methods, the new approach generalizes a previously...... proposed simulation method for one-dimensional bridges to the mulit-variate setting. First a method of simulating approzimate, but often very accurate, diffusion bridges is proposed. These approximate bridges are used as proposal for easily implementable MCMC algorithms that produce exact diffusion bridges...

  15. Numerical analysis of dynamic response of vehicle–bridge coupled system on long-span continuous girder bridge

    Directory of Open Access Journals (Sweden)

    Lipeng An

    2016-07-01

    Full Text Available To systematically study the vehicle–bridge coupled dynamic response and its change rule with different parameters, a vehicle model with seven degrees of freedom was built and the total potential energy of vehicle space vibration system was deduced. Considering the stimulation of road roughness, the dynamic response equation of vehicle–bridge coupled system was established in accordance with the elastic system principle of total potential energy with stationary value and the “set-in-right-position” rule. On the basis of the self-compiled Fortran program and bridge engineering, the dynamic response of long-span continuous girder bridge under vehicle load was studied. This study also included the calculation of vehicle impact coefficient, evaluation of vibration comfort, and analysis of dynamic response parameters. Results show the impact coefficient changes with lane number and is larger than the value calculated by the “general code for design of highway bridges and culverts (China”. The Dieckmann index of bridge vibration is also related to lane number, and the vibration comfort evaluation is good in normal conditions. The relevant conclusions from parametric analyses have practical significance to dynamic design and daily operation of long-span continuous girder bridges in expressways. Safety and comfort are expected to improve significantly with further control of the vibration of vehicle–bridge system.

  16. Study of Nonlinear Seismic Response and TMD Primary Control of the Cable-Stayed Bridge Section of the Third Macao-Taipa Bridge

    Institute of Scientific and Technical Information of China (English)

    Long Xiaohong; Li Li

    2004-01-01

    The practical design of the cable-stayed bridge of the 3rd Macao-Taipa bridge is investigated by the finite element analysis program ANSYS, and 3-D elements BEAM188 and BEAM4 are adopted to create a dynamic calculation model. In order to analyze the material nonlinear seismic response of the cable-stayed bridge, the nonlinear behaviors of the ductile plastic hinges of the bridge towers are taken into account by employing the nonlinear rotational spring element COMBIN40. To simulate a major earthquake, three earthquake records were chosen using a wave-choosing program and input into the bridge structure along longitudinal and transversal directions. Comparisons of the linear and nonlinear seismic responses of the cable-stayed bridge are performed. In addition, a study of TMD primary control is carried out using element MASS21 and element COMBIN14, and it is indicated that the effects of mitigation monitoring are evident.

  17. 23 CFR 650.411 - Procedures for bridge replacement and rehabilitation projects.

    Science.gov (United States)

    2010-04-01

    ... Rehabilitation Program § 650.411 Procedures for bridge replacement and rehabilitation projects. (a) Consideration... the State to the Secretary in accordance with 23 CFR part 630, subpart A Federal-Aid Programs... 23 Highways 1 2010-04-01 2010-04-01 false Procedures for bridge replacement and...

  18. Bridging as Coercive Accommodation

    CERN Document Server

    Bos, J W; Mineur, A M; Bos, Johan; Buitelaar, Paul; Mineur, Anne-Marie

    1995-01-01

    In this paper we discuss the notion of "bridging" in Discourse Representation Theory as a tool to account for discourse referents that have only been established implicitly, through the lexical semantics of other referents. In doing so, we use ideas from Generative Lexicon theory, to introduce antecedents for anaphoric expressions that cannot be "linked" to a proper antecedent, but that do not need to be "accommodated" because they have some connection to the network of discourse referents that is already established.

  19. Bridging Classroom Language Ethnography

    OpenAIRE

    GRENFELL, MICHAEL JAMES

    2012-01-01

    PUBLISHED Paper #5: Bridging Classroom Language Ethnography, New Literacy Studies and Bourdieu?s Social Philosophy: Principles and Practice The purpose of this paper is to analyze and synthesize the various ways that classroom language ethnography, NLS, and Bourdieu?s social philosophy, were integrated. The goal of the analysis and synthesis is to provide a fresh perspective and fruitful insights on literacy in all its manifestations that provides the foundations for a more robust...

  20. Temperature profile data collected using XBTs from the GOLDEN GATE BRIDGE from the Pacific Ocean during the Thermal Structure Monitoring Program in the Pacific (TRANSPAC) project, 1977-02-22 to 1977-03-01 (NCEI Accession 8100293)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using bathythermograph (BT/XBT) casts from GOLDEN GATE BRIDGE in the Pacific Ocean from February 22, 1977 to March 1, 1977....

  1. Temperature profile data collected using XBTs from the GOLDEN GATE BRIDGE from the Pacific Ocean during the Thermal Structure Monitoring Program in the Pacific (TRANSPAC) project, 1977-04-09 to 1977-04-17 (NCEI Accession 8100290)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using bathythermograph (BT/XBT) casts from GOLDEN GATE BRIDGE in the Pacific Ocean from April 9, 1977 to April 17, 1977. Data...

  2. Quantitative Detection of Screening for Cervical Lesions with ThinPrep Cytology Test

    Institute of Scientific and Technical Information of China (English)

    Hong-xin ZHANG; Yi-min SONG; Su-hong LI; Yu-hui YIN; Dong-ling GAO; Kui-sheng CHEN

    2010-01-01

    OBJECTIVE To investigate the available parameters in gynecological screening for cervical lesions by liquid-based cytology technology (ThinPrep Cytology Test, TCT) and The Bethesda System (TBS), also with computer image analysis. METHODS With application of the image analysis system, all grades of cervical lesion cells were detected quantitatively and sorted in atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells-cannot exclude HSIL (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma (SCC) with the mean optical density (MOD), average grey (AG), positive units (PU), and nucleus to cytoplasmic ratio (N:C). Differences between each group of cells were compared and analyzed statistically.RESULTS Apart from four stereologic parameters in LSIL and HSIL groups there were no differences among them, in the other groups, there was statistically significant in differences between MOD, AG and PU values. Differences between them in the ratio of nucleus to cytoplasm were highly statistically signifi cant. CONCLUSION Stereological indexes may serve as a screening tool for cervical lesions. The image analysis system is expected to become a new means of cytological assisted diagnosis.

  3. Morphologic features of prostatic adenocarcinoma on ThinPrep® urinary cytology.

    Science.gov (United States)

    Tyler, Kevin L; Selvaggi, Suzanne M

    2011-02-01

    Malignant cells of prostatic adenocarcinoma are rarely identified in urine. In most cases, this finding is associated with high stage tumor. Numerous descriptions of the morphology of prostatic adenocarcinoma have been reported using cytocentrifugated specimens. However, no specific morphologic description of prostatic adenocarcinoma in urine using liquid-based cytology has been previously described. Four cases of prostatic adenocarcinoma in urine using ThinPrep® liquid-based preparations were identified between 2002 and 2009 at the University of Wisconsin Hospital and Clinics. Three patients had either high stage tumor or metastatic disease at the time of diagnosis, while the remaining patient had low stage tumor. The morphology of each case was evaluated with specific attention to cell size, nuclear characteristics, nuclear to cytoplasmic ratio, and cytoplasmic characteristics. The resulting key features for prostatic adenocarcinoma in urine are clustering, increased nuclear to cytoplasmic ratio, and prominent nucleoli. Though typically the presence of prostatic adenocarcinoma in urine implies high stage tumor, cells of lower stage tumors may be seen in urine as well.

  4. Environmental life cycle assessment comparison between two bridge types: reinforced concrete bridge and steel composite bridge

    DEFF Research Database (Denmark)

    Du, Guangli; Karoumi, Raid

    2013-01-01

    not been integrated into the decision-making process. This paper presents a systematic LCA method for quantifying the environmental impacts for bridges. The comparison study is performed between a reinforced concrete bridge and a steel bridge as an alternative design, with several key maintenance and EOL......The concept of sustainable construction has attracted an increased attention. Bridge infrastructures and their belonged construction activities consume considerable material and energy, which is responsible for large environmental burdens. However, the environmental assessment of bridges has...

  5. Effectiveness and cost effectiveness of oral pre-exposure prophylaxis in a portfolio of prevention programs for injection drug users in mixed HIV epidemics.

    Directory of Open Access Journals (Sweden)

    Sabina S Alistar

    Full Text Available BACKGROUND: Pre-exposure prophylaxis with oral antiretroviral treatment (oral PrEP for HIV-uninfected injection drug users (IDUs is potentially useful in controlling HIV epidemics with a significant injection drug use component. We estimated the effectiveness and cost effectiveness of strategies for using oral PrEP in various combinations with methadone maintenance treatment (MMT and antiretroviral treatment (ART in Ukraine, a representative case for mixed HIV epidemics. METHODS AND FINDINGS: We developed a dynamic compartmental model of the HIV epidemic in a population of non-IDUs, IDUs who inject opiates, and IDUs in MMT, adding an oral PrEP program (tenofovir/emtricitabine, 49% susceptibility reduction for uninfected IDUs. We analyzed intervention portfolios consisting of oral PrEP (25% or 50% of uninfected IDUs, MMT (25% of IDUs, and ART (80% of all eligible patients. We measured health care costs, quality-adjusted life years (QALYs, HIV prevalence, HIV infections averted, and incremental cost effectiveness. A combination of PrEP for 50% of IDUs and MMT lowered HIV prevalence the most in both IDUs and the general population. ART combined with MMT and PrEP (50% access averted the most infections (14,267. For a PrEP cost of $950, the most cost-effective strategy was MMT, at $520/QALY gained versus no intervention. The next most cost-effective strategy consisted of MMT and ART, costing $1,000/QALY gained compared to MMT alone. Further adding PrEP (25% access was also cost effective by World Health Organization standards, at $1,700/QALY gained. PrEP alone became as cost effective as MMT at a cost of $650, and cost saving at $370 or less. CONCLUSIONS: Oral PrEP for IDUs can be part of an effective and cost-effective strategy to control HIV in regions where injection drug use is a significant driver of the epidemic. Where budgets are limited, focusing on MMT and ART access should be the priority, unless PrEP has low cost.

  6. Preliminary Investigation of the Systematic Approach to the Repair Versus Replacement Decision-Making Process for Deteriorated Concrete Bridge Decks.

    Science.gov (United States)

    1986-06-26

    Developing State Transportation Programs.............. 161 6.3 Bridge Management System ................... 163 6.4 Components of the Systematic Decision...144 Figure 6-1 Schematic of State Transportation Management and Bridge Management System .................................... 160 Figure 6-2...briefly highlights the general concepts associated with an overall bridge management system . Specifically, the chap- ter identifies the components or the

  7. 23 CFR 661.49 - Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges?

    Science.gov (United States)

    2010-04-01

    ..., and Toll Road IRR bridges? 661.49 Section 661.49 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.49 Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges? Yes....

  8. The active-bridge oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Wessendorf, K.O.

    1998-07-01

    This paper describes the Active-Bridge Oscillator (ABO), a new concept in high-stability oscillator design. The ABO is ab ridge-type oscillator design that is easly to design and overcomes many of the operational and design difficulties associated with standard bridge oscillator designs. The ABO will oscillate with a very stable output amplitude over a wide range of operating conditions without the use of an automatic-level-control (ALC). A standard bridge oscillator design requires an ALC to maintain the desired amplitude of oscillation. for this and other reasons, bridge oscilaltors are not used in mainstream designs. Bridge oscillators are generally relegated to relatively low-volume, high-performance applications. The Colpitts and Pierce designs are the most popular oscillators but are typically less stable than a bridge-type oscillator.

  9. Vulnerability of bridges to fire

    DEFF Research Database (Denmark)

    Giuliani, Luisa; Crosti, C.; Gentili, F.

    2012-01-01

    Even if recent effort in developing methodology and measures for design structures against fire and explosions has been mostly focused on buildings, bridges can also be very sensitive to those actions, as witnesses by some recent bridge accidents, which caused major economic losses and also...... endangered people safety in few cases. Purpose of this paper is making a focus on the state of the art of the research and current regulations concerning the response of bridges to fire. Several cases of bridge fires are reported and a focus is made on the occurrence and consequence of bridge fires......, considering both the costs deriving by structural damages and by limited serviceability and other indirect societal aspects. Few cases of recent bridge fire are reviewed in detail and structural consequences are highlighted, distinguishing between damages directly induced by fire and damages induced by local...

  10. Bridge Aesthetics and Structural Honesty

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    In bridges the overall form must be chosen with due respect to the transmission of forces if efficient structures shall be created, The design must therefore be governed by experienced structural engineers - in some cases assisted by aesthetic advisers on specific issues. Some basic requirements...... decisive for choosing the form of trusses, arches and cable-stayed bridges are outlined, and several examples show bridges designed without giving priority to the structural aspects....

  11. Morphological aspects of myocardial bridges.

    Science.gov (United States)

    Lujinović, Almira; Kulenović, Amela; Kapur, Eldan; Gojak, Refet

    2013-11-01

    Although some myocardial bridges can be asymptomatic, their presence often causes coronary disease either through direct compression of the "tunnel" segment or through stimulation and accelerated development of atherosclerosis in the segment proximally to the myocardial bridge. The studied material contained 30 human hearts received from the Department of Anatomy. The hearts were preserved 3 to 5 days in 10% formalin solution. Thereafter, the fatty tissue was removed and arterial blood vessels prepared by careful dissection with special reference to the presence of the myocardial bridges. Length and thickness of the bridges were measured by the precise electronic caliper. The angle between the myocardial bridge fibre axis and other axis of the crossed blood vessel was measured by a goniometer. The presence of the bridges was confirmed in 53.33% of the researched material, most frequently (43.33%) above the anterior interventricular branch. The mean length of the bridges was 14.64 ± 9.03 mm and the mean thickness was 1.23 ± 1.32 mm. Myocardial bridge fibres pass over the descending blood vessel at the angle of 10-90 degrees. The results obtained on a limited sample suggest that the muscular index of myocardial bridge is the highest for bridges located on RIA, but that the difference is not significant in relation to bridges located on other branches. The results obtained suggest that bridges located on other branches, not only those on RIA, could have a great contractive power and, consequently, a great compressive force, which would be exerted on the wall of a crossed blood vessel.

  12. Modular FRP Composite Bridge Deck

    OpenAIRE

    ECT Team, Purdue

    2007-01-01

    The bridge infrastructure of the United States is in constant need of repair and rehabilitation. It is reported that 43% of the bridges in the USA have been identified as being structurally deficient or functionally obsolete due to corrosion. SuperdeckTM, a non-corrosive fiber reinforced polymer (FRP) composite bridge deck. The Deck is designed and engineered into a lightweight, strong and rigid structure that will not corrode. The deck sections, composed of hexagon and double-trapezoid profi...

  13. Bridging Literature and Linguistics

    Directory of Open Access Journals (Sweden)

    Abdul Wahab

    2002-01-01

    Full Text Available Abstract: Two majors linguistics and literature in the schools of letters both in the state and private universities throughout Indonesia are commonly separated sharply. Courses of literature in the Department of Linguistics are offered minimally, such that the students of linguistics are not given a conducive atmosphere to express their literary appreciation. Likewise, courses of linguistics in the Department of Literature are very restricted, so that the students of literature are unable to analyze literary works from the points of linguistic view. This paper tries to bridge linguistics and literature. The attempt to bridge linguistics and literature is based on three postulates: (I literature consists of linguistic objects designed with an artistic end, (2 linguistic objects are formal objects, and (3 a formal account of linguistic object designed with an artistic end approximates a formal account of that artistic design. Two major directions in the approaches and emphases will be presented in the paper exogenous and endogenous. Exogenous approach tries to search for adequate description of (1 poetic language as contrasted with ordinary language, (2 language of a particular author contrasted with that of other authors, and (3 a particular literary work contrasted with other works of the same author. This part touches upon three areas of exogenous approach isolation, description, and characterization. Endogenous, on the hand, is based upon an assumption that a writer exhibits, probably without realizing it, certain systematic preferences for particular aspects of linguistic patterns. Planning a bridge between linguistics and literature is by no means without problems. Therefore, this paper also presents some possible solutions.

  14. Bridging Literature and Linguistics

    Directory of Open Access Journals (Sweden)

    Abdul Wahab

    2003-01-01

    Full Text Available Two majors linguistics and literature in the schools of letters both in the state and private universities throughout Indonesia are commonly separated sharply. Courses of literature in the Department of Linguistics are offered minimally, such that the students of linguistics are not given a conducive atmosphere to express their literary appreciation. Likewise, courses of linguistics in the Department of Literature are very restricted, so that the students of literature are unable to analyze literary works from the points of linguistic view. This paper tries to bridge linguistics and literature. The attempt to bridge linguistics and literature is based on three postulates: (1 literature consists of linguistic objects designed with an artistic end, (2 linguistic objects are formal objects, and (3 a formal account of linguistic object designed with an artistic end approximates a formal account of that artistic design. Two major directions in the approaches and emphases will be presented in the paper exogenous and endogenous. Exogenous approach tries to search for adequate description of (1 poetic language as contrasted with ordinary language, (2 language of a particular author contrasted with that of other authors, and (3 a particular literary work contrasted with other works of the same author. This part touches upon three areas of exogenous approach isolation, description, and characterization. Endogenous, on the hand, is based upon an assumption that a writer exhibits, probably without realizing it, certain systematic preferences for particular aspects of linguistic patterns. Planning a bridge between linguistics and literature is by no means without problems. Therefore, this paper also presents some possible solutions.

  15. Linguistic Barriers and Bridges

    DEFF Research Database (Denmark)

    Thuesen, Frederik

    2016-01-01

    The influence of language on social capital in low-skill and ethnically diverse workplaces has thus far received very limited attention within the sociology of work. As the ethnically diverse workplace is an important social space for the construction of social relations bridging different social...... and intercultural communication, this article analyses interviews with 31 employees from two highly ethnically diverse Danish workplaces. The article shows how linguistic barriers such as different levels of majority language competence and their consequent misunderstandings breed mistrust and hostility, whilst...

  16. Bridging The Inferential Gap

    Science.gov (United States)

    Stewart, Walter F.; Shah, Nirav R.; Selna, Mark J.; Paulus, Ronald A.; Walker, James M.

    2009-01-01

    Most clinical decisions involve bridging the inferential gap: Clinicians are required to “fill in” where they lack knowledge or where no knowledge yet exists. In this context we consider how the inferential gap is a product, in part, of how knowledge is created, the limits to gaining access to such knowledge, and the variable ways in which knowledge is translated into decisions. We consider how electronic health records (EHRs) will help narrow this gap by accelerating the creation of evidence relevant to everyday practice needs and facilitating real-time use of knowledge in practice. PMID:17259202

  17. Thermal bridges of modern windows

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

    2013-01-01

    With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even if the wi......With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even...

  18. Modelling railway bridge asset management

    OpenAIRE

    Le, Bryant Linh Hai

    2014-01-01

    The UK has a long history in the railway industry with a large number of railway assets. Railway bridges form one of the major asset groups with more than 35,000 bridges. The majority of the bridge population are old being constructed over 100 years ago. Many of the bridges were not designed to meet the current network demand. With an expected increasing rate of deterioration due to the increasing traffic loads and intensities, the management authorities are faced with the difficult task of k...

  19. Chem-Prep PZT 95/5 for neutron generator applications : development of laboratory-scale powder processing operations.

    Energy Technology Data Exchange (ETDEWEB)

    Montoya, Ted V.; Moore, Roger Howard; Spindle, Thomas Lewis Jr.

    2003-12-01

    Chemical synthesis methods are being developed as a future source of PZT 95/5 powder for neutron generator voltage bar applications. Laboratory-scale powder processes were established to produce PZT billets from these powders. The interactions between calcining temperature, sintering temperature, and pore former content were studied to identify the conditions necessary to produce PZT billets of the desired density and grain size. Several binder systems and pressing aids were evaluated for producing uniform sintered billets with low open porosity. The development of these processes supported the powder synthesis efforts and enabled comparisons between different chem-prep routes.

  20. OligoPrep PVA support for oligonucleotide synthesis in columns on a scale up to 10 micromol.

    Science.gov (United States)

    Aitken, Sheena; Anderson, Emma

    2007-01-01

    OligoPrep is a macroporous polyvinylacetate (PVA) biodegradable support that has been designed for cost-effective automated synthesis of oligonucleotides using standard phosphoramidite chemistry. Originally developed for large-scale oligonucleotide synthesis in beds and reactors, we present here its utility for medium-scale work of 1-10 micromol in column syntheses on standard DNA synthesizers. We show how an increase in scale, and, therefore, yield, can be achieved without significant increase in reagent quantity. Additional deblock and oxidation cycles can provide high coupling yields, and the use of concentrated ammonia in aqueous methylamine (AMA) for oligonucleotide cleavage and deprotection results in excellent recovery.

  1. Efectos de una dosis baja de bisfenol A sobre el eje reproductor de ratas machos prepúberes

    OpenAIRE

    Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Ponzo, Osvaldo Juan; Carbone, Silvia Elena; Pandolfi, Matias; Scacchi, Pablo; Reynoso, Roxana María

    2015-01-01

    El objetivo del presente trabajo fue estudiar el efecto de una dosis baja de bisfenol A (BPA) sobre el eje reproductor de ratas macho prepúberes, expuestas durante la gestación y la lactancia. Se trató a ratas hembra preñadas con una dosis aproximada de exposición de BPA de 3 mg, administrado en el agua de bebida, y el tratamiento continuó durante la lactancia. Las crías macho fueron sacrificadas a los 35 días de vida, etapa prepuberal. Se evaluó el peso corporal durante el desarrollo de las...

  2. Evaluation of Existing Bridge Maintenance Management Practices for Application to the Army.

    Science.gov (United States)

    1987-09-01

    This element of a bridge management system provides the raw information used to determine the M&R requirements and to prioritize and program projects...Current Practice Most states use the Federal Sufficiency Rating (FSR) or a variant of it as the analysis element of their network level bridge management system . The...the function of a network level bridge management system , which is to give administrators and engineers greater flexibility in making tradeoffs

  3. Evaluation Behavior of Qing Shan Concrete Bridge under Static Load Test

    Directory of Open Access Journals (Sweden)

    Haleem K. Hussain

    2011-07-01

    Full Text Available This study describes and evaluates the state of Qing Shang Bridge. The deterioration of bridge can be summarized due to increased internal forces may be a result of higher loading or due to the sever climatic and environmental weathers changes, bridges need reinforcement because damage due to external factors which reduced the cross-sectional resistance to external loads. The assessment of traffic loading on bridges is subject to large levels of uncertainty. While some allowance is provided in design codes for variable traffic conditions, they are conservative to allow for generalization at a safe level. Also this article identify the design demands of Qing Shan bridge which is located in China/ Heilongjiang Province, He gang - Nen Jiang Road 303 provincial highway, Wu Da Lian Chi area, is an important bridge in the urban areas. The investigation program was include the observation and evaluate the damage in T-section concrete beams , box girder bridges section in additional evaluate the whole state of bridges under static load test, the use of Finite Element Analysis was preferred method to study the behavior of concrete. Furthermore the load test program includes the main beams of bridge. The test results show that the bridge in general structural condition is good. T beam girder of the span No. 10 was tested for static load and need to be strengthening. The concrete box girder shows good state of condition, and no seriously damage effects.

  4. "I did not want to give birth to a child who has HIV": Experiences using PrEP during pregnancy among HIV-uninfected Kenyan women in HIV-serodiscordant couples.

    Science.gov (United States)

    Pintye, Jillian; Beima-Sofie, Kristin M; Kimemia, Grace; Ngure, Kenneth; Trinidad, Susan Brown; Heffron, Renee; Baeten, Jared; Odoyo, Josephine; Mugo, Nelly; Bukusi, Elizabeth A; Kelley, Maureen C; John-Stewart, Grace C

    2017-07-31

    The perceptions, motivations, and beliefs of HIV-uninfected women about PrEP use during pregnancy can influence its uptake and adherence. This study elicited the views of HIV-uninfected women with personal experience taking PrEP during pregnancy. Qualitative interviews were conducted with HIV-uninfected women who had personal experience taking PrEP while pregnant. Semi-structured interviews were conducted with 21 HIV-uninfected Kenyan women in HIV-serodiscordant couples enrolled in an open-label PrEP demonstration project who became pregnant while using PrEP and continued PrEP through their pregnancy. Interviews were audio-recorded and transcribed into English. A qualitative descriptive analysis was performed, using a constant comparison approach to identify key themes related to PrEP use in pregnancy. Desire to remain HIV-uninfected and have an HIV-free infant were strong motivators influencing continued use of PrEP during pregnancy. Supporting HIV-infected partners and childbearing within an HIV-serodiscordant relationship were also motivators. Women had challenges distinguishing normal pregnancy symptoms from PrEP side effects and were concerned that observed side effects could be signs of danger for the infant related to PrEP exposure. Healthcare providers were important conduits of knowledge about PrEP, and continuity of PrEP providers throughout pregnancy facilitated adherence. HIV-uninfected women in HIV-serodiscordant couples were motivated to use PrEP during pregnancy to remain HIV-uninfected and to have an HIV-free child, but had concerns about side effects. Healthcare providers will be important for PrEP messaging and adherence support in this unique population.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without

  5. Intimate Partner Violence and Adherence to HIV Pre-exposure Prophylaxis (PrEP) in African Women in HIV Serodiscordant Relationships: A Prospective Cohort Study.

    Science.gov (United States)

    Roberts, Sarah T; Haberer, Jessica; Celum, Connie; Mugo, Nelly; Ware, Norma C; Cohen, Craig R; Tappero, Jordan W; Kiarie, James; Ronald, Allan; Mujugira, Andrew; Tumwesigye, Elioda; Were, Edwin; Irungu, Elizabeth; Baeten, Jared M

    2016-11-01

    Intimate partner violence (IPV) is associated with higher HIV incidence, reduced condom use, and poor adherence to antiretroviral therapy and other medications. IPV may also affect adherence to pre-exposure prophylaxis (PrEP). We analyzed data from 1785 HIV-uninfected women enrolled in a clinical trial of PrEP among African HIV serodiscordant couples. Experience of verbal, physical, or economic IPV was assessed at monthly visits by face-to-face interviews. Low PrEP adherence was defined as clinic-based pill count coverage <80% or plasma tenofovir levels <40 ng/mL. The association between IPV and low adherence was analyzed using generalized estimating equations, adjusting for potential confounders. In-depth interview transcripts were examined to explain how IPV could impact adherence. Sixteen percent of women reported IPV during a median of 34.8 months of follow-up (interquartile range 27.0-35.0). Overall, 7% of visits had pill count coverage <80%, and 32% had plasma tenofovir <40 ng/mL. Women reporting IPV in the past 3 months had increased risk of low adherence by pill count (adjusted risk ratio 1.49, 95% confidence interval: 1.17 to 1.89) and by plasma tenofovir (adjusted risk ratio 1.51, 95% confidence interval: 1.06 to 2.15). Verbal, economic, and physical IPV were all associated with low adherence. However, the impact of IPV diminished and was not statistically significant 3 months after the reported exposure. In qualitative interviews, women identified several ways in which IPV affected adherence, including stress and forgetting, leaving home without pills, and partners throwing pills away. Women who reported recent IPV in the Partners PrEP Study were at increased risk of low PrEP adherence. Strategies to mitigate PrEP nonadherence in the context of IPV should be evaluated.

  6. 75 FR 67992 - Voluntary Private Sector Accreditation and Certification Preparedness Program

    Science.gov (United States)

    2010-11-04

    ... [Federal Register Volume 75, Number 213 (Thursday, November 4, 2010)] [Notices] [Page 67992] [FR... 75 FR 60773 announcing an initial plan to address small business concerns in the PS-Prep Program.... W. Craig Fugate, Administrator, Federal Emergency Management Agency. [FR Doc. 2010-27828 Filed...

  7. 75 FR 60773 - Voluntary Private Sector Accreditation and Certification Preparedness Program

    Science.gov (United States)

    2010-10-01

    ... Preparedness Program AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of PS-Prep Small Business... conformity process. Recommendations for: Information to include in the guidance for small business support... plan to address small business concerns in the Voluntary Private Sector Accreditation and Certification...

  8. Fatigue tests on aluminium bridges

    NARCIS (Netherlands)

    Maljaars, J.; Soetens, F.; Straalen, IJ.J. van

    2004-01-01

    Traffic bridges are subjected to variable loads and should therefore be checked on fatigue. Especially low weight materials, like aluminium, are sensitive to fatigue, because the variable load is a substantial part of the total load. This paper shows the structural design of an aluminium bridge load

  9. Fatigue tests on aluminium bridges

    NARCIS (Netherlands)

    Maljaars, J.; Soetens, F.; Straalen, IJ.J. van

    2005-01-01

    Traffic bridges are subjected to variable loads and should therefore be checked on fatigue. Especially low weight materials, like aluminium, are sensitive to fatigue, because the variable load is a substantial part of the total load. This paper shows the structural design of an aluminium bridge load

  10. London Bridge Is Shaking Funny

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Bridges generally don’t fall down without warning;they crack first. Searching for cracks is a tedious business,though, and bridge inspectors bave been known to miss them. Charles Farrar,a civil engineer at Los Alamos Na-

  11. The Cobas AmpliPrep/Cobas TaqMan HCV Test, Version 2.0, Real-Time PCR Assay Accurately Quantifies Hepatitis C Virus Genotype 4 RNA

    OpenAIRE

    Chevaliez, Stéphane; Bouvier-Alias, Magali; Rodriguez, Christophe; Soulier, Alexandre; Poveda, Jean-Dominique; Pawlotsky, Jean-Michel

    2013-01-01

    Accurate hepatitis C virus (HCV) RNA quantification is mandatory for the management of chronic hepatitis C therapy. The first-generation Cobas AmpliPrep/Cobas TaqMan HCV test (CAP/CTM HCV) underestimated HCV RNA levels by >1-log10 international units/ml in a number of patients infected with HCV genotype 4 and occasionally failed to detect it. The aim of this study was to evaluate the ability of the Cobas AmpliPrep/Cobas TaqMan HCV test, version 2.0 (CAP/CTM HCV v2.0), to accurately quantify H...

  12. Development of cooperative system bridges

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhe; WAN Qi-bai; SHI Lei

    2008-01-01

    Cooperative system bridges comprise several basic structures that act jointly to improve structural characteristics. We delved into the historical development of cooperative system bridges. Cooperative systems are classified as different-load cooperative systems and same-load cooperative systems by distinguishing the modes of load distribution. For different-load cooperation, individual basic structures are at different positions in the direction along bridge axis and carry the loads separately. While for same-load cooperation, all basic structures overlap in geometrical locations and support the entire loads conjointly. The choosing of span ratios between basic structures, the design of connections of different-load cooperative systems were discussed as well as optimizations of relative rigidity for same-load cooperative systems which greatly influence structural characteristics. The general situation and several structural measurements of several cooperative bridges were demonstrated. This information can assist engineers in developing their concepts in cooperative systems and can lead to more efficient and economical cooperative bridges.

  13. Linguistic Barriers and Bridges

    DEFF Research Database (Denmark)

    Thuesen, Frederik

    2016-01-01

    and intercultural communication, this article analyses interviews with 31 employees from two highly ethnically diverse Danish workplaces. The article shows how linguistic barriers such as different levels of majority language competence and their consequent misunderstandings breed mistrust and hostility, whilst......The influence of language on social capital in low-skill and ethnically diverse workplaces has thus far received very limited attention within the sociology of work. As the ethnically diverse workplace is an important social space for the construction of social relations bridging different social...... groups, the sociology of work needs to develop a better understanding of the way in which linguistic diversity influences the formation of social capital, i.e. resources such as the trust and reciprocity inherent in social relations in such workplaces. Drawing on theories about intergroup contact...

  14. Electrothermally Tunable Bridge Resonator

    KAUST Repository

    Hajjaj, Amal Z.

    2016-12-05

    This paper demonstrates experimentally, theoretically, and numerically a wide-range tunability of an in-plane clamped-clamped microbeam, bridge, and resonator compressed by a force due to electrothermal actuation. We demonstrate that a single resonator can be operated at a wide range of frequencies. The microbeam is actuated electrothermally, by passing a DC current through it. We show that when increasing the electrothermal voltage, the compressive stress inside the microbeam increases, which leads eventually to its buckling. Before buckling, the fundamental frequency decreases until it drops to very low values, almost to zero. After buckling, the fundamental frequency increases, which is shown to be as high as twice the original resonance frequency. Analytical results based on the Galerkin discretization of the Euler Bernoulli beam theory are generated and compared to the experimental data and to simulation results of a multi-physics finite-element model. A good agreement is found among all the results.

  15. Cascaded resonant bridge converters

    Science.gov (United States)

    Stuart, Thomas A. (Inventor)

    1989-01-01

    A converter for converting a low voltage direct current power source to a higher voltage, high frequency alternating current output for use in an electrical system where it is desired to use low weight cables and other circuit elements. The converter has a first stage series resonant (Schwarz) converter which converts the direct current power source to an alternating current by means of switching elements that are operated by a variable frequency voltage regulator, a transformer to step up the voltage of the alternating current, and a rectifier bridge to convert the alternating current to a direct current first stage output. The converter further has a second stage series resonant (Schwarz) converter which is connected in series to the first stage converter to receive its direct current output and convert it to a second stage high frequency alternating current output by means of switching elements that are operated by a fixed frequency oscillator. The voltage of the second stage output is controlled at a relatively constant value by controlling the first stage output voltage, which is accomplished by controlling the frequency of the first stage variable frequency voltage controller in response to second stage voltage. Fault tolerance in the event of a load short circuit is provided by making the operation of the first stage variable frequency voltage controller responsive to first and second stage current limiting devices. The second stage output is connected to a rectifier bridge whose output is connected to the input of the second stage to provide good regulation of output voltage wave form at low system loads.

  16. Evaluating the effectiveness of PrepSTART for promoting oral language and emergent literacy skills in disadvantaged preparatory students.

    Science.gov (United States)

    Lennox, Maria; Westerveld, Marleen F; Trembath, David

    2016-09-19

    This study examined the effectiveness of a classroom-based intervention programme aimed at improving the oral language and emergent literacy skills of students from low socio-economic, culturally diverse backgrounds within their first formal year of schooling ("prep"). Data from 137 students were available for analysis. Participants were from three primary schools located in Queensland, Australia. Eight classes were allocated to intervention and two classes acted as a business as usual control. All students received literacy instruction as per the Australian Curriculum. However, the intervention group received 24 weeks of scripted, classroom-based, book-based intervention targeting code- and meaning-related emergent literacy skills. All students were assessed individually pre- and post-intervention on code-related measures (i.e. letter identification and phonological awareness) and meaning-related measures (i.e. vocabulary, oral narrative comprehension and retell). All students made significant improvement over time for all measures. Students in the intervention group showed significantly more progress than the business as usual group on all measures, except for letter identification and oral narrative comprehension. This classroom-based book-based intervention can improve the code- and meaning-related emergent literacy skills of prep students from low socio-economic backgrounds and provide these students with the building blocks for successful literacy acquisition.

  17. Percentage recovery of dioxin homologue through power-prep according to the eluting solvents and their amounts

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Tae-Uk [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science]|[National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Kim, Dong-Gyu [National Veterinary Research and Quarantine Service (Korea). Seoul Regional Office; Choi, Si-Weon [National Veterinary Research and Quarantine Service (Korea). Busan Regional Office; Seo, Dong-Cheol; Jeo, Jong-Soo [Gyeongsang National Univ., Jinju (Korea). Division of Applied Life Science; Lee, Hong-Jae [Jinju National Univ. (Korea). Dept. of Environmental Engineering

    2004-09-15

    Because of the persistence and accumulation of polychlorinated dibenzo dioxins(PCDDs) and polychlorinated dibenzo furans(PCDFs) in the environment, dioxins contamination is regarded as a global issue. And various methods for analyzing PCDDs and PCDFs have been developed and improved. According to US EPA method, cleanup method was very various. Conventional cleanup methods are very dependable, but are time consuming and use large volumes of organic solvents. To increase the efficiency of cleanup for the analysis of PCDDs and PCDFs, we used high speed automated sample cleanup system for dioxins which is called Power-Prep trademark (Fluid Management System Inc., USA). Power- Prep trademark gave us swift analysis of dioxin and its precision and accuracy. This system was designed to cleanup of toxic compound such as dioxins, PCBs, pesticides and PAHs using silica, alumina and carbon column. Using this system, it is possible to conduct several samples in less than 1.5 hours, thereby, achieving high recoveries and excellent precision and accuracy for all dioxin congeners. In this experiment, we carried out PCDDs and PCDFs analysis by FMS(Fluid Management System Inc.) with 3 eluting solvents such as toluene, hexane and dichloromethane to find out the best eluting solvent and its amounts.

  18. Torsional instability in suspension bridges: The Tacoma Narrows Bridge case

    Science.gov (United States)

    Arioli, Gianni; Gazzola, Filippo

    2017-01-01

    All attempts of aeroelastic explanations for the torsional instability of suspension bridges have been somehow criticised and none of them is unanimously accepted by the scientific community. We suggest a new nonlinear model for a suspension bridge and we perform numerical experiments with the parameters corresponding to the collapsed Tacoma Narrows Bridge. We show that the thresholds of instability are in line with those observed the day of the collapse. Our analysis enables us to give a new explanation for the torsional instability, only based on the nonlinear behavior of the structure.

  19. 23 CFR 650.407 - Application for bridge replacement or rehabilitation.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Application for bridge replacement or rehabilitation. 650.407 Section 650.407 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Rehabilitation Program § 650.407 Application for bridge replacement or rehabilitation. (a) Agencies...

  20. Fatigue crack identification and lifetime prediction for steel bridge deck structures

    NARCIS (Netherlands)

    Pahlavan, P.L.; Pijpers, R.J.M.; Hakkesteegt, H.C.; Jansen, T.H.; Peelen, W.H.A.

    2015-01-01

    Fatigue, as the governing degradation mechanism in steel bridge decks, can lead to non-inspectable cracks under the welded intersections of stiffeners to the deck plate. As a result, estimation of the remaining service life and optimization of the maintenance program of steel bridge decks become a g

  1. 23 CFR 973.210 - Indian lands bridge management system (BMS).

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Indian lands bridge management system (BMS). 973.210 Section 973.210 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS... PROGRAM Bureau of Indian Affairs Management Systems § 973.210 Indian lands bridge management system...

  2. Behavior of FRP Link Slabs in Jointless Bridge Decks

    Directory of Open Access Journals (Sweden)

    Aziz Saber

    2012-01-01

    Full Text Available The paper investigated the use of fiberglass-reinforced plastic (FRP grid for reinforcement in link slabs for jointless bridge decks. The design concept of link slab was examined based on the ductility of the fiberglass-reinforced plastic grid to accommodate bridge deck deformations. The implementation of hybrid simulation assisted in combining the experimental results and the theoretical work. The numerical analyses and the experimental work investigated the behavior of the link slab and confirmed its feasibility. The results indicated that the technique would allow simultaneous achievement of structural need, lower flexural stiffness of the link slab approaching the behavior of a hinge, and sustainability need of the link slab. The outcome of the study supports the contention that jointless concrete bridge decks may be designed and constructed with fiberglass-reinforced plastic grid link slabs. This concept would also provide a solution to a number of deterioration problems associated with bridge deck joints and can be used during new construction of bridge decks. The federal highway administration provided funds to Louisiana Department of Transportation through the innovative bridge research and development program to implement the use of FRP grid as link slab.

  3. A Decision Support System for Concrete Bridge Maintenance

    Science.gov (United States)

    Rashidi, Maria; Lemass, Brett; Gibson, Peter

    2010-05-01

    The maintenance of bridges as a key element in transportation infrastructure has become a major concern for asset managers and society due to increasing traffic volumes, deterioration of existing bridges and well-publicised bridge failures. A pivotal responsibility for asset managers in charge of bridge remediation is to identify the risks and assess the consequences of remediation programs to ensure that the decisions are transparent and lead to the lowest predicted losses in recognized constraint areas. The ranking of bridge remediation treatments can be quantitatively assessed using a weighted constraint approach to structure the otherwise ill-structured phases of problem definition, conceptualization and embodiment [1]. This Decision Support System helps asset managers in making the best decision with regards to financial limitations and other dominant constraints imposed upon the problem at hand. The risk management framework in this paper deals with the development of a quantitative intelligent decision support system for bridge maintenance which has the ability to provide a source for consistent decisions through selecting appropriate remediation treatments based upon cost, service life, product durability/sustainability, client preferences, legal and environmental constraints. Model verification and validation through industry case studies is ongoing.

  4. Incorporation of nondestructive evaluation in Pontis Bridge Management System

    Science.gov (United States)

    Hadavi, Ahmad

    1998-03-01

    The highway system in the United States includes nearly 577,000 bridges, the majority of which were built during two major bridge building periods -- just before World War II (1930s) and in the first two decades of the Cold War (1950s and 1960s). Given the age and increased usage of these bridges over the years, many now require substantial maintenance to satisfy their desired level of service. The complex task of allocating scarce funds for the repair, maintenance, and rehabilitation of this large number of bridges led to the development of several optimization studies and two major bridge management system, namely BRIDGIT and Pontis. Pontis has emerged as the system of choice for all states in the Nation. At this time over 40 highway agencies continue to license, evaluate and implement the current AASHTOWARE Program, Pontis V. 3.2. However, all data currently required by Pontis to assess the structural stability and resulting suggestions for repair and maintenance of bridges are based on visual inspection and judgement. Consequently, all suggestions are based on that visual inspection. This paper discusses development of a plan for how non-destructive evaluation (NDE) data can be used to provide more information than visual inspection.

  5. National Bridge Inventory - National Geospatial Data Asset (NGDA) Bridges

    Data.gov (United States)

    Department of Transportation — The NBI (NTAD 2015) is a collection of information (database) describing the more than 610,000 of the Nation's bridges located on public roads, including Interstate...

  6. Bridge Creek IMW database - Bridge Creek Restoration and Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The incised and degraded habitat of Bridge Creek is thought to be limiting a population of ESA-listed steelhead (Oncorhynchus mykiss). A logical restoration approach...

  7. Reliability Assessment of Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle; Middleton, C. R.

    This paper is partly based on research performed for the Highways Agency, London, UK under the project DPU/9/44 "Revision of Bridge Assessment Rules Based on Whole Life Performance: concrete bridges". It contains the details of a methodology which can be used to generate Whole Life (WL) reliability...... profiles. These WL reliability profiles may be used to establish revised rules for concrete bridges. This paper is to some extend based on Thoft-Christensen et. al. [1996], Thoft-Christensen [1996] et. al. and Thoft-Christensen [1996]....

  8. General design of Sutong Bridge

    Institute of Scientific and Technical Information of China (English)

    Zhang Xigang; Yuan Hong; Pei Minshan; Dai Jie; Xu Lin

    2009-01-01

    The main span of Sutong Bridge is a double-pylon, double-plane cable-stayed bridge with steel box girder, which has the world's longest central span of 1 088 m within cable-stayed bridges. To overcome problems caused by severe meteorological conditions, perplexing hydrological conditions, deep buried bedrock and higher navigation level, many new technics and methods were created. Keys including structural system, steel box girder, stayed cable, tower, pier, tower foundation, collision avoidance system, wind-resistance, seismic-resistance, structural nonlinear response and structural static stability were presented individually in this paper.

  9. Hydraulic and geomorphic monitoring of experimental bridge scour mitigation at selected bridges in Utah, 2003-05

    Science.gov (United States)

    Kenney, Terry A.; McKinney, Tim S.

    2006-01-01

    Unique bridge scour mitigation designs using concrete A-Jacks were developed by the Utah Department of Transportation and installed at the Colorado River Bridge at State Road 191 and the Green River Bridge at State Road 19. The U.S. Geological Survey monitored stream reaches at these sites by collecting streambed-topography and water-velocity data from 2003 through 2005. These data were acquired annually from a moving boat with an acoustic Doppler current profiler and a differential global positioning system. Raw unordered data were processed and readied for interpolation into organized datasets with DopplerMacros, a set of computer programs. Processed streambed topography data were geostatistically interpolated by using Ordinary Kriging, and inverse distance weighting interpolation was used in the development of the two-dimensional velocity datasets. These organized datasets of topography and velocity were developed for each survey of the two bridge sites. A comparison of the riverbed topography data for each survey was done. An increase in bed elevation related to the installation of the A-Jacks scour countermeasures is evident at the Colorado River Bridge at State Road 191. The three topographic datasets acquired after the installation at the Green River Bridge at State Road 19 show few changes.

  10. FBG application in bridge health monitoring system of Wuhan Yangtze River 2nd Bridge

    Science.gov (United States)

    Liu, Jun

    2009-10-01

    For the traditional resistance strain sensor's shortage,for example,their stability,durability and monitoring scorpe could not satisfied the requirement of bridge monitoring system,put forward to adopt advanced fiber-optic bragg grating sensor and its technology to build up the bridge health monitoring system.Analysed the application scope and aim of difference kinds of fiber bragg grating sensors used, including stress strain sensors,temperature sensors,crack sensors and testing force ring sensors.According to the key construction sections as the project designed,expatiated their specific installation methods and construction craftwork in Wuhan Yangtze River 2th bridge.It formed distributed fiber sensing network of bridge with large-scale located fiber-optic bragg grating sensors, and pointed out the becareful prodeeding when to link no more than twenty sensors to one fiber for the demodulator precision.Discussed how to construct the data acquisition system and its function via the sensors and their demodulator.One fiber of the linked sensors connected to one channel of the demodulator and all together reached sixteen channels.The demodulator were connected to the switch through rj45 interface and communicated with the acquisition server.Designed the software program of data acquisition software system and the database,which used the Sqlite of the embed database to storage the configure information and receive the data through the TCP/IP protocol.It has been build a bridge health monitoring system base on fiber bragg grating technology.

  11. Access to Basic HIV-Related Services and PrEP Acceptability among Men Who Have sex with Men Worldwide: Barriers, Facilitators, and Implications for Combination Prevention

    Directory of Open Access Journals (Sweden)

    George Ayala

    2013-01-01

    Full Text Available Introduction. Men who have sex with men (MSM are disproportionately impacted by HIV globally. Easily accessible combination HIV prevention strategies, tailored to the needs of MSM, are needed to effectively address the AIDS pandemic. Methods and Materials. We conducted a cross-sectional study among MSM (n=3748 from 145 countries from April to August 2012. Using multivariable random effects models, we examined factors associated with acceptability of preexposure prophylaxis (PrEP and access to condoms, lubricants, HIV testing, and HIV treatment. Results. Condoms and lubricants were accessible to 35% and 22% of all respondents, respectively. HIV testing was accessible to 35% of HIV-negative respondents. Forty-three percent of all HIV-positive respondents reported that antiretroviral therapy was easily accessible. Homophobia, outness, and service provider stigma were significantly associated with reduced access to services. Conversely, community engagement, connection to gay community, and comfort with service providers were associated with increased access. PrEP acceptability was associated with lower PrEP-related stigma, less knowledge about PrEP, less outness, higher service provider stigma, and having experienced violence for being MSM. Conclusions. Ensuring HIV service access among MSM will be critical in maximizing the potential effectiveness of combination approaches, especially given the interdependence of both basic and newer interventions like PrEP. Barriers and facilitators of HIV service access for MSM should be better understood and addressed.

  12. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  13. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

    Science.gov (United States)

    Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein; Kirschner, Benny; Rozemeijer, Kirsten; Bonde, Jesper; Rygaard, Carsten; Lynge, Elsebeth

    2015-01-01

    Background: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories. Methods: Using data from five nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests an indicator of relative specificity. Results: At 23–29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30–44 years, the increase with SurePath/FocalPoint was 58% the 16% increase with ThinPrep was not significant. At 45–59 years, both technologies led to nonsignificant decreases in the detection. SurePath/FocalPoint doubled the frequency of false-positive tests at any age. With ThinPrep, these proportions remained the same at 23–29 years, but decreased by two-thirds at 45–59 years. In a fourth laboratory with continuous use of manually read conventional cytology, no such trends were seen. Conclusions: The sensitivity and specificity of modern LBC and computer-assisted reading technologies may be brand- and age-dependent. PMID:26448176

  14. "Get a Blue and You Will See Your Money Back Again": Staffing and Marketing the English Prep School, 1890-1912

    Science.gov (United States)

    Benson, John

    2014-01-01

    This article explores the ways in which English prep schools were staffed and marketed in the years before the First World War. Its aim more specifically is to employ a biographical approach to consider the emphasis that the schools placed upon sport, and in particular the extent to which they recruited Oxford and Cambridge Blues as teachers…

  15. The Effect of Metacognitive Strategy Training on Science Process Skills and Science Self Efficacy among First Year Prep Students with Learning Disabilities

    Science.gov (United States)

    Gomaa, Omema Mostafa Kamel

    2016-01-01

    This study investigated the effect of using metacognitive strategy training on science process skills and science self efficacy in learning disabled first year prep students. A total of 60 students identified with LD were invited to participate. The sample was randomly divided into two groups; experimental (n = 30 boys) and control (n = 30 boys ).…

  16. Bridge for the Xs: A New Career Services Model.

    Science.gov (United States)

    Murray, Neil

    1993-01-01

    Examines whether career services professionals are keeping in touch with the attitudes of the new generation of college students and are filling their needs and desires. Explores what it is that these new clients want from career services and suggests a variety of bridging programs that will help students move from school to work. (NB)

  17. The Higgs Bridge

    CERN Document Server

    Allen, Roland E

    2013-01-01

    The particle recently discovered at the Large Hadron Collider near Geneva is almost certainly a Higgs boson, the long-sought completion of the Standard Model of particle physics. But this discovery, an achievement by more than six thousand scientists (including students), is actually much more than a mere capstone of the Standard Model. It instead represents a bridge from the Standard Model to exciting discoveries of the future, at higher energies or in other experiments, and to the properties of matter at very low temperatures. The mere existence of a particle with zero spin implies a need for new physics, with the most likely candidate being supersymmetry, which requires that every known particle has a superpartner yet to be discovered. And phenomena similar to the Higgs are seen in superconducting metals and superfluid gases at low temperatures, which extend down to a millionth or even a billionth of a degree Kelvin. So the discovery of a Higgs boson has a central place in our attempts both to achieve a tr...

  18. Mineral bridges in nacre revisited

    CERN Document Server

    Checa, Antonio G; Willinger, Marc-Georg

    2012-01-01

    We confirm with high-resolution techniques the existence of mineral bridges between superposed nacre tablets. In the towered nacre of both gastropods and the cephalopod Nautilus there are large bridges aligned along the tower axes, corresponding to gaps (150-200 nm) in the interlamellar membranes. Gaps are produced by the interaction of the nascent tablets with a surface membrane that covers the nacre compartment. In the terraced nacre of bivalves bridges associated with elongated gaps in the interlamellar membrane (> 100 nm) have mainly been found at or close to the edges of superposed parental tablets. To explain this placement, we hypothesize that the interlamellar membrane breaks due to differences in osmotic pressure across it when the interlamellar space below becomes reduced at an advanced stage of calcification. In no cases are the minor connections between superimposed tablets (< 60 nm), earlier reported to be mineral bridges, found to be such.

  19. The stories of two bridges in Ghana

    DEFF Research Database (Denmark)

    Andreasen, Jørgen

    2004-01-01

    Public participation in bridge building was promoted by un habitat in the village of Mankrong. The neighbouring village did not participate in the construction of their bridge. The first flooding washed the second bridge down while the "participative bridge" stood up....

  20. Nonlinear programming analysis and methods

    CERN Document Server

    Avriel, Mordecai

    2012-01-01

    This text provides an excellent bridge between principal theories and concepts and their practical implementation. Topics include convex programming, duality, generalized convexity, analysis of selected nonlinear programs, techniques for numerical solutions, and unconstrained optimization methods.

  1. Introduction of the Thin Prep Imaging System™ (TIS: Experience in a high volume academic practice

    Directory of Open Access Journals (Sweden)

    Chivukula Mamatha

    2007-01-01

    Full Text Available Objective: Since the introduction of the liquid-based ThinPrep testing in 1996, most cytology laboratories across the country have adopted the liquid-based cytology (LBC for Pap test screening. Subsequent to wide-spread adoption of the ThinPrep Pap test, the ThinPrep Imaging System (TIS Cytyc Corp, Marlborough, MA was introduced to improve the accuracy and efficiency of screening interpretation. We report our initial experience with the TIS at Magee Women′s Hospital. We introduced the TIS in December 2004. Methods: The imager assisted Pap test results over the first 12 months (December 2004 to December 2005 of implementation were reviewed and analyzed. Our implementation protocol included each cytotechnologist manually prescreening 200 negative slides to gain experience with the imager slides and serve as a quality check for the TIS. We re-screened 3400 slides (200 slides each for 17 cytotechnologists manually which were initially determined to be negative using the TIS. 104,457 Pap tests were imaged on the TIS. 95,899 manually screened Pap tests, 12 months prior to the introduction of the TIS (December 2003-November 2004 are taken as the historic control group for our study. Results :The mean ASC-US rate employing the automated imager was 8.70% [9088/104,457]. The mean LSIL detection rate was 4.22% [4409/104,457]. The imager did not miss any detectible high-grade lesions during these months, with a HSIL (+ detection rate of 0.68% in comparison to 0.60% by manual screening confirmed by follow-up biopsies. The difference is statistically significant with a p value of 0.022 . The definition of false negative rate for purposes of this study is calculated as the number of false negative cases identified out of number of negatives re-screened. The TIS false negative rate was estimated at 0.012% [4/3400]. Conclusion :The overall performance of the TIS in our lab appears to be highly satisfactory in terms of improving sensitivity in screening

  2. Acceptability of an open-label wait-listed trial design: Experiences from the PROUD PrEP study

    Science.gov (United States)

    Brodnicki, Elizabeth; Desai, Monica; McCormack, Sheena; Nutland, Will; Wayal, Sonali; White, Ellen; Wood, Gemma; Barber, Tristan; Bell, Gill; Clarke, Amanda; Dolling, David; Dunn, David; Fox, Julie; Haddow, Lewis; Lacey, Charles; Nardone, Anthony; Quinn, Killian; Rae, Caroline; Reeves, Iain; Rayment, Michael; White, David; Apea, Vanessa; Ayap, Wilbert; Dewsnap, Claire; Collaco-Moraes, Yolanda; Schembri, Gabriel; Sowunmi, Yinka; Horne, Rob

    2017-01-01

    Background PROUD participants were randomly assigned to receive pre-exposure prophylaxis (PrEP) immediately or after a deferred period of one-year. We report on the acceptability of this open-label wait-listed trial design. Methods Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. We also conducted in-depth interviews (IDI) with a purposely selected sub-sample of participants. Results Acceptability questionnaires were completed by 76% (415/544) of participants. After controlling for age, immediate-group participants were almost twice as likely as deferred-group participants to complete the questionnaire (AOR:1.86;95%CI:1.24,2.81). In quantitative data, the majority of participants in both groups found the wait-listed design acceptable when measured by satisfaction of joining the study, intention to remain in the study, and interest in joining a subsequent study. However, three-quarters thought that the chance of being in the deferred-group might put other volunteers off joining the study. In free-text responses, data collection tools were the most frequently reported least liked aspect of the study. A fifth of deferred participants reported ‘being deferred’ as the thing they least liked about the study. However, more deferred participants disliked the data collection tools than the fact that they had to wait a year to access PrEP. Participants in the IDIs had a good understanding of the rationale for the open-label wait-listed study design. Most accepted the design but acknowledged they were, or would have been, disappointed to be randomised to the deferred group. Five of the 25 participants interviewed reported some objection to the wait-listed design. Conclusion The quantitative and qualitative findings suggest that in an environment where PrEP was not available, the rationale for the wait-listed trial design was well understood and

  3. Evaluation of the Illumina(®) Beta Version ForenSeq™ DNA Signature Prep Kit for use in genetic profiling.

    Science.gov (United States)

    Churchill, Jennifer D; Schmedes, Sarah E; King, Jonathan L; Budowle, Bruce

    2016-01-01

    While capillary electrophoresis-based technologies have been the mainstay for human identity typing applications, there are limitations with this methodology's resolution, scalability, and throughput. Massively parallel sequencing (MPS) offers the capability to multiplex multiple types of forensically-relevant markers and multiple samples together in one run all at an overall lower cost per nucleotide than traditional capillary electrophoresis-based methods; thus, addressing some of these limitations. MPS also is poised to expand forensic typing capabilities by providing new strategies for mixture deconvolution with the identification of intra-STR allele sequence variants and the potential to generate new types of investigative leads with an increase in the overall number and types of genetic markers being analyzed. The beta version of the Illumina ForenSeq DNA Signature Prep Kit is a MPS library preparation method with a streamlined workflow that allows for targeted amplification and sequencing of 63 STRs and 95 identity SNPs, with the option to include an additional 56 ancestry SNPs and 22 phenotypic SNPs depending on the primer mix chosen for amplification, on the MiSeq desktop sequencer (Illumina). This study was divided into a series of experiments that evaluated reliability, sensitivity of detection, mixture analysis, concordance, and the ability to analyze challenged samples. Genotype accuracy, depth of coverage, and allele balance were used as informative metrics for the quality of the data produced. The ForenSeq DNA Signature Prep Kit produced reliable, reproducible results and obtained full profiles with DNA input amounts of 1ng. Data were found to be concordant with current capillary electrophoresis methods, and mixtures at a 1:19 ratio were resolved accurately. Data from the challenged samples showed concordant results with current DNA typing methods with markers in common and minimal allele drop out from the large number of markers typed on these

  4. A Program Based on English Digital Stories to Develop the Writing Performance and Reflective Thinking of Preparatory School Pupils

    Science.gov (United States)

    Hassan Seifeddin, Ahmed; Zakareya Ahmed, Samah; Yahia Mohammed Ebrahim, Eman

    2015-01-01

    This study aimed to investigate the effect of a program based on English digital stories on second-year preparatory pupils' writing performance and reflective thinking. Two writing performance tests (pretest and posttest) as well as a reflective thinking test were prepared by the researchers. Two 2nd-year intact classes from El Sadat Prep School…

  5. SURGERY OF SYMPTOMATIC MYOCARDIAL BRIDGING

    Directory of Open Access Journals (Sweden)

    N. Maghamipour N. Safaei

    2007-06-01

    Full Text Available Myocardial bridging with systolic compression of the left anterior descending coronary artery (LAD may be associated with myocardial ischemia. In symptomatic myocardial bridging unresponsive to medical treatment, surgical unroofing of the left LAD can be performed. Little information is available about the long-term prognosis of patients with this coronary anomaly after the surgical unroofing, so we decided to evaluate the result of this operation. A total of 26 patients underwent surgical unroofing of myocardial bridging. Patients had a myocardial bridge of at least 3 cm in length in the middle of LAD and with more than 70% compression during systole. Unroofing was performed with cardiopulmonary bypass in 16 and with off pump technique in 10 patients. In 6 patients repeat angiographies for control of myotomy were done. In one of them a nonsignificant 20% narrowing was seen. Postoperative scintigraphic and angiographic studies demonstrated restoration of coronary flow and myocardial perfusion without residual myocardial bridges under beta-stimulation in 24 patients. Two patients had residual narrowing. With off pump technique, 1 patient had perforation of the right ventricle and 1 patient underwent reoperation because of incomplete unroofing during the first operation. None of the patients with cardiopulmonary bypass technique had residual chest pain or other complications. Surgical unroofing of myocardial bridging with the aid of cardiopulmonary bypass is a safe and easy procedure with low operative risk and with excellent functional results.

  6. Redundancy Evaluation of Fracture Critical Bridges

    OpenAIRE

    Bapat, Amey Vivek

    2014-01-01

    Cases of brittle fractures in major bridges prompted AASHTO to publish its first fracture control plan in 1978. It focused on material and fabrication standards, and required periodic 24-month hands-on inspection of bridges with fracture critical members. The practical result of this plan was to significantly increase the life cycle cost of these bridges, rendering them uneconomical. Apart from the Point Pleasant Bridge that failed in 1967, no other bridge has collapsed in the USA following a...

  7. Building Bridges: Experiential and Integrative Learning in a Canadian Women's Prison

    Science.gov (United States)

    Pollack, Shoshana

    2016-01-01

    This article reports on a study of student experiences of a Walls to Bridges (W2B) class taught by Faculty of Social Work instructors in a Canadian women's prison. The Walls to Bridges (W2B) program is based on the U. S. Inside-Out Prison Exchange Program and brings students from the university together with students from the prison to study for a…

  8. Fine-needle aspiration cytology of mammary fibroadenoma: a comparison of ThinPrep® and cytospin preparations.

    Science.gov (United States)

    Ly, Thai Yen; Barnes, Penny J; Macintosh, Rebecca F

    2011-03-01

    Mammary fibroadenoma (FA) is a lesion frequently sampled and diagnosed by fine-needle aspiration (FNA). Accurate cytologic diagnosis of this common benign lesion is important as this can lead to non-surgical, conservative management when breast imaging and clinical examination are concordant. In most instances, a confident diagnosis of FA is possible because of a characteristic cytologic appearance that includes hypercellularity, large epithelial cell groups, staghorn epithelial configurations, stromal fragments, and numerous background stripped nuclei. Nevertheless, FAs can be diagnostically challenging because of shared cytomorphologic features with other benign lesions and low-grade carcinoma. As such, FA is a well-recognized source of false results on FNA cytology. Furthermore, there are reports that newer thin layer cytopreparatory techniques, including the ThinPrep® (TP) system (Hologic Corp., Bedford, MA), alter the appearance of FA on FNA compared to conventional preparations and may compromise accurate cytologic diagnosis. Copyright © 2010 Wiley-Liss, Inc.

  9. Probabilistic model for bridge structural evaluation using nondestructive inspection data

    Science.gov (United States)

    Carrion, Francisco; Lopez, Jose Alfredo; Balankin, Alexander

    2005-05-01

    A bridge management system developed for the Mexican toll highway network applies a probabilistic-reliability model to estimate load capacity and structural residual life. Basic inputs for the system are the global inspection data (visual inspections and vibration testing), and the information from the environment conditions (weather, traffic, loads, earthquakes); although, the model takes account for additional non-destructive testing or permanent monitoring data. Main outputs are the periodic maintenance, rehabilitation and replacement program, and the updated inspection program. Both programs are custom-made to available funds and scheduled according to a priority assignation criterion. The probabilistic model, tailored to typical bridges, accounts for the size, age, material and structure type. Special bridges in size or type may be included, while in these cases finite element deterministic models are also possible. Key feature is that structural qualification is given in terms of the probability of failure, calculated considering fundamental degradation mechanisms and from actual direct observations and measurements, such as crack distribution and size, materials properties, bridge dimensions, load deflections, and parameters for corrosion evaluation. Vibration measurements are basically used to infer structural resistance and to monitor long term degradation.

  10. Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.

    Directory of Open Access Journals (Sweden)

    Sebastiaan M Bol

    Full Text Available BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD. While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocognitive disorders persist with a high prevalence. To identify additional therapeutic targets for treating HIV-associated neurocognitive disorders, several candidate gene polymorphisms have been evaluated, but few have been replicated across multiple studies. METHODS: We here tested 7 candidate gene polymorphisms for association with HAD in a case-control study consisting of 86 HAD cases and 246 non-HAD AIDS patients as controls. Since infected monocytes and macrophages are thought to play an important role in the infection of the brain, 5 recently identified single nucleotide polymorphisms (SNPs affecting HIV-1 replication in macrophages in vitro were also tested. RESULTS: The CCR5 wt/Δ32 genotype was only associated with HAD in individuals who developed AIDS prior to 1991, in agreement with the observed fading effect of this genotype on viral load set point. A significant difference in genotype distribution among all cases and controls irrespective of year of AIDS diagnosis was found only for a SNP in candidate gene PREP1 (p = 1.2 × 10(-5. Prep1 has recently been identified as a transcription factor preferentially binding the -2,518 G allele in the promoter of the gene encoding MCP-1, a protein with a well established role in the etiology of HAD. CONCLUSION: These results support previous findings suggesting an important role for MCP-1 in the onset of HIV-1-associated neurocognitive disorders.

  11. Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study

    Science.gov (United States)

    d'Assuncao, Jefferson; Irwig, Les; Macaskill, Petra; Chan, Siew F; Richards, Adele; Farnsworth, Annabelle

    2007-01-01

    Objective To compare the accuracy of liquid based cytology using the computerised ThinPrep Imager with that of manually read conventional cytology. Design Prospective study. Setting Pathology laboratory in Sydney, Australia. Participants 55 164 split sample pairs (liquid based sample collected after conventional sample from one collection) from consecutive samples of women choosing both types of cytology and whose specimens were examined between August 2004 and June 2005. Main outcome measures Primary outcome was accuracy of slides for detecting squamous lesions. Secondary outcomes were rate of unsatisfactory slides, distribution of squamous cytological classifications, and accuracy of detecting glandular lesions. Results Fewer unsatisfactory slides were found for imager read cytology than for conventional cytology (1.8% v 3.1%; Pcytology (7.4% v 6.0% overall and 2.8% v 2.2% for cervical intraepithelial neoplasia of grade 1 or higher). Among 550 patients in whom imager read cytology was cervical intraepithelial neoplasia grade 1 or higher and conventional cytology was less severe than grade 1, 133 of 380 biopsy samples taken were high grade histology. Among 294 patients in whom imager read cytology was less severe than cervical intraepithelial neoplasia grade 1 and conventional cytology was grade 1 or higher, 62 of 210 biopsy samples taken were high grade histology. Imager read cytology therefore detected 71 more cases of high grade histology than did conventional cytology, resulting from 170 more biopsies. Similar results were found when one pathologist reread the slides, masked to cytology results. Conclusion The ThinPrep Imager detects 1.29 more cases of histological high grade squamous disease per 1000 women screened than conventional cytology, with cervical intraepithelial neoplasia grade 1 as the threshold for referral to colposcopy. More imager read slides than conventional slides were satisfactory for examination and more contained low grade cytological

  12. Optimization Analysis Model of Self-Anchored Suspension Bridge

    Directory of Open Access Journals (Sweden)

    Pengzhen Lu

    2014-01-01

    Full Text Available The hangers of self-anchored suspension bridge need to be tensioned suitably during construction. In view of this point, a simplified optimization calculation method of cable force for self-anchored suspension bridge has been developed based on optimization theories, such as minimum bending energy method, and internal force balanced method, influence matrix method. Meanwhile, combined with the weak coherence of main cable and the adjacently interaction of hanger forces, a simplified analysis method is developed using MATLAB, which is then compared with the optimization method that consider the main cable's geometric nonlinearity with software ANSYS in an actual example bridge calculation. This contrast proves the weak coherence of main cable displacement and the limitation of the adjacent cable force influence. Furthermore, a tension program that is of great reference value has been developed; some important conclusions, advices, and attention points have been summarized.

  13. Thermal Effect of the Cable-Stayed Bridge Tower

    Institute of Scientific and Technical Information of China (English)

    Zhang Hai-long; Li Jun; Liu Chang-guo; Jiang Tian-hua; Wei jun

    2003-01-01

    This paper studies the thermal effect of the cable-stayed bridge tower based on full time accurate measurement and finite element analysis on Xiantao Hanjiang River Highway Bridge. The measured results and the displacement variation of top tower show that the tower rotates periodically when it is exposed in sunshine. But the tower column will not decline when there is no sunshine. In spite of in winter or in summer, the period when the tower column changed smallest is from 0∶00 am to 5∶00 am. The time period when the tower column has maximum deviation lags behind the time when the tower column has maximum temperature difference, and this phenomenon is obvious in winter. The conclusions also have directive value in predicting the tower deformations and their directions in construction control of cable-stayed bridge, and in verifying the finite element program.

  14. The Akashi Kaikyo Bridge and the Storebælt Bridge

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    With the completion of the Akashi Kaikyo Bridge and the Storebælt East Bridge the development of the suspension bridge technology in the 20th century has manifested itself in two impressive structures. With the present echnology may bridges of similar (and also more modest) dimensions...... will undoubtedly be built far into the next century. For bridges going beyond the spans of existing bridges it is, however, likely that new concepts will be developed....

  15. Weigh-in-motion and smart bridges

    Science.gov (United States)

    Lai, Leon L.

    1997-05-01

    The bridge Weigh-In-Motion (WIM) system uses bridge structures as weigh scales to measure axle and gross vehicle weights and vehicle configurations without stopping or detouring the vehicles. Because the system is mobile and is almost invisible to the truck drivers, it can be used to collect unbiased traffic data for transportation and loadometer study. The WIM + RESPONSE system, which is an expansion of the original WIM system, was developed to collect additional bridge response data and perform bridge structural evaluation. These additional bridge response data provide bridge engineers with information necessary for improving bridge design and evaluation procedures. Bridge health monitoring and damage detection may also be conducted with long term installation of the WIM + RESPONSE system. This paper discusses what has been achieved by the WIM + RESPONSE system and how the system can be further improved to enhance its functions in a smart bridge.

  16. A strange bridge by Leonardo

    CERN Document Server

    Huylebrouck, Dirk

    2013-01-01

    On folio 855 recto of the Codex Atlanticus, Leonardo da Vinci drew three 'easily movable' bridges, but one of them is enigmatic: all 'replicas' in Leonardo museums and exhibitions come as a surprise, to say the least, to any engineer or architect whose attention is drawn to it. This is the case for models in Amboise (France), Chicago and Portland (USA), Florence (Italy) and for the one of the traveling exhibition by the Australian company 'Grande Exhibitions' that already visited 40 major cities in the world. All 'replicas' of the bridge model attributed to Leonardo have pillars standing on the deck of the bridge, while the deck is suspended by cables attached on these pillars. At first sight this problem does not catch the attention of the observer, as the bridge seems to be a mixed form of a beam and a suspension bridge, but it was not overlooked by my colleague architect-engineer Dr. Laurens Luyten (Gent, Belgium). Yet, after a TV-interview in Brussels so much pressure was exerted by some of the museum col...

  17. River ice jams at bridges

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, D. [New Brunswick Dept. of Transportation, Fredericton, NB (Canada); Beltaos, S. [National Water Research Institute, Burlington, ON (Canada)

    2000-12-01

    Ice jamming, known to cause high water levels at even moderate river flows, is described as both the main and least understood source of ice-related bridge damages. This paper describes a joint study by the New Brunswick Department of Transportation, the Department of the Environment, local governments, and the National Water Research Institute, designed to address problems associated with the interaction of ice jams and bridges. The study consists of collecting information at each of four sites in New Brunswick including: historical data on ice jam locations, causes, and water levels; channel bathymetry, width and slope within each study centred at the respective bridge; and documentation of ice conditions throughout the ice season, including measurement of ice cover thickness, observation of breakup mechanisms, times, causes, characteristics and possible impacts of ice jam release. Data analysis will include determination of high stages due to ice jams or surges caused by upstream ice jam releases, scour potential of surges, and quantification of the structure's capacity to restrain ice movement and to cause jams. The principal objective of the study is to advance beyond empiricism and to develop rational design criteria for bridges by anticipating the effects of climate changes and by incorporating local meteorological and hydrometric records into bridge design for added safety.

  18. Floating liquid bridge charge dynamics

    Science.gov (United States)

    Teschke, Omar; Soares, David Mendez; Gomes, Whyllerson Evaristo; Valente Filho, Juracyr Ferraz

    2016-01-01

    The interaction of liquid with electric fields is investigated in a configuration where up to 13 kV are applied between electrodes resulting in a 106 V/m electric field in the capillaries and where there is the formation of a free-standing fluid bridge in the interelectrode gap. The Mott-Gurney equation was fitted to the measured ionization current vs applied voltage curve which indicates that the ionization rate at the high-voltage anode electrode dimethylsulfoxide (DMSO) interface and space charging in the interelectrode gap determine the floating liquid bridge current for a given cathode-to-anode voltage. Space charge effects were measured in the cathode becker and also at the liquid bridge since the ionized charges at the anode migrate to the bridge outer surface and decrease the interfacial tension from 43 mJ/m2 to 29 mJ/m2. Two distinct structural regions then form the bridge, a charged plastic (bulk modulus ˜100 MPa) conducting outer layer with a surface conductivity of ˜10-9 Ω-1, which shapes and supports the floating fluid structure, and an inner liquid cylinder, where DMSO molecules flow.

  19. A Case Study in Effectively Bridging the Business Skills Gap for the Information Technology Professional

    Science.gov (United States)

    Gorman, Michael F.

    2011-01-01

    A longitudinal study of information technology (IT) managers at a Fortune 200 company in the Southwest United States was conducted to assess the effectiveness of a training program at bridging the perceived business skills gap for IT employees. A needs assessment was carried out, resulting in a 4-module training program. The program was evaluated…

  20. A Case Study in Effectively Bridging the Business Skills Gap for the Information Technology Professional

    Science.gov (United States)

    Gorman, Michael F.

    2011-01-01

    A longitudinal study of information technology (IT) managers at a Fortune 200 company in the Southwest United States was conducted to assess the effectiveness of a training program at bridging the perceived business skills gap for IT employees. A needs assessment was carried out, resulting in a 4-module training program. The program was evaluated…

  1. Thermal bridges of modern windows

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

    2013-01-01

    With its focus on reduced energy consumption, contemporary housing construction requires a highly insulated and airtight building envelope with as few thermal bridges as possible.Windows must be carefully designed, as thermal bridges can lead to surface condensation or mold growth, even...... if the window has an U-factor of 1 W/(m2·K) or lower. This paper describes the development of modern, energy efficient Danish windows with reduced thermal bridges. It focuses on materials, geometry, and sealing of window panes based on a literature review. Examples of modern windows are presented. Experience...... with the minimum acceptable surface temperature regarding surface condensation or mold growth, implemented in the Danish Building Regulations in 2010, and the calculation method for this temperature based on international standards is discussed. The introduction of the minimum acceptable surface temperature has...

  2. Contactless Bridge Weigh-in-Motion

    OpenAIRE

    Ojio, T.; Carey, Ciaran; O'Brien, Eugene J.; Doherty, C; Taylor, S E

    2016-01-01

    Bridge weigh-in-motion (WIM) uses existing bridges to find the weights of vehicles that pass overhead. Contactless bridge weigh-in-motion (cBWIM) uses bridges to weigh vehicles without the need for any sensors to be attached to the bridge. A camera is mounted on the back of a telescope, which magnifies the image to the extent that submillimeter bridge deflections can be measured accurately. A second camera is used to monitor traffic and to determine axle spacings. The two cameras are synchron...

  3. Bridging faults in BiCMOS circuits

    Science.gov (United States)

    Menon, Sankaran M.; Malaiya, Yashwant K.; Jayasumana, Anura P.

    1993-01-01

    Combining the advantages of CMOS and bipolar, BiCMOS is emerging as a major technology for many high performance digital and mixed signal applications. Recent investigations revealed that bridging faults can be a major failure mode in IC's. Effects of bridging faults in BiCMOS circuits are presented. Bridging faults between logical units without feedback and logical units with feedback are considered. Several bridging faults can be detected by monitoring the power supply current (I(sub DDQ) monitoring). Effects of bridging faults and bridging resistance on output logic levels were examined along with their effects on noise immunity.

  4. An Expert System for Concrete Bridge Management

    DEFF Research Database (Denmark)

    Brito, J. de; Branco, F. A.; Thoft-Christensen, Palle

    1997-01-01

    management systems are presently being implemented by bridge authorities in several countries. The prototype of an expert system for concrete bridge management is presented in this paper, with its functionality relying on two modules. The inspection module relies on a periodic acquisition of field......The importance of bridge repair versus new bridge construction has risen in recent decades due to high deterioration rates that have been observed in these structures. Budgets both for building new bridges and keeping the existing ones are always limited. To help rational decision-making, bridge...

  5. Effect of Thin Prep® imaging system on laboratory rate and relative sensitivity of atypical squamous cells, high-grade squamous intraepithelial lesion not excluded and high-grade squamous intraepithelial lesion interpretations

    OpenAIRE

    Brooke R Koltz; Russell, Donna K; Naiji Lu; Bonfiglio, Thomas A.; Sharlin Varghese

    2013-01-01

    Introduction: Automated screening of Thin Prep ® Papanicolaou Tests has become increasingly common in clinical practice. Increased productivity has initiated laboratory use of the Thin Prep ® Imaging System (TIS). Increased sensitivity is a potential additional benefit of TIS. Published studies have shown an increase in discovery of dysplastic cells. This study evaluates the effect of TIS on the incidence of atypical squamous cells high-grade squamous intraepithelial lesion not excluded (ASC-...

  6. Performance evaluation of the new Roche cobas AmpliPrep/cobas TaqMan HCV test, version 2.0, for detection and quantification of hepatitis C virus RNA

    NARCIS (Netherlands)

    S.D. Pas (Suzan); R. Molenkamp (Richard); J. Schinkel (Janke); S. Rebers; C. Copra (Cederick); S. Seven-Deniz; D. Thamke (Diana); R.J. de Knegt (Robert); B.L. Haagmans (Bart); M. Schutten (Martin)

    2013-01-01

    textabstractTo evaluate the analytical performance and explore the clinical applicability of the new Roche cobas AmpliPrep/cobas TaqMan HCV test, v2.0 (CAP/CTM v2.0), a platform comparison was performed on panels and diagnostic samples with the Roche cobas AmpliPrep/cobas TaqMan HCV test (CAP/CTM v1

  7. Balanced bridge feedback control system

    Science.gov (United States)

    Lurie, Boris J. (Inventor)

    1990-01-01

    In a system having a driver, a motor, and a mechanical plant, a multiloop feedback control apparatus for controlling the movement and/or positioning of a mechanical plant, the control apparatus has a first local bridge feedback loop for feeding back a signal representative of a selected ratio of voltage and current at the output driver, and a second bridge feedback loop for feeding back a signal representative of a selected ratio of force and velocity at the output of the motor. The control apparatus may further include an outer loop for feeding back a signal representing the angular velocity and/or position of the mechanical plant.

  8. Excitation Methods for Bridge Structures

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, C.R.; Duffy, T.A.; Cornwell, P.J.; Doebling, S.W.

    1999-02-08

    This paper summarizes the various methods that have been used to excited bridge structures during dynamic testing. The excitation methods fall into the general categories of ambient excitation methods and measured-input excitation methods. During ambient excitation the input to the bridge is not directly measured. In contrast, as the category label implies, measured-input excitations are usually applied at a single location where the force input to the structure can be monitored. Issues associated with using these various types of measurements are discussed along with a general description of the various excitation methods.

  9. Optimum selection on bridge erection with floating crane in East China Sea Bridge and Hangzhou Bay Bridge

    Institute of Scientific and Technical Information of China (English)

    Shunquan Qin; Pu Zhou; Youheng Hua

    2004-01-01

    @@ Introduction With the rapid development of China′s economy, many bridges will be built over the Chinese coastal waters of Pacific Ocean. Among them, construction of East China Sea Bridge has been commenced in June 2001, and will be completed at the end of 2005, Hangzhou Bay Bridge was also started to construct in June 2003(Fig. 1). These two ultralong bridges are designed as twin expressway bridges standing side by side each carries a 3-lane one-way carriageway. The total width is 31.5m and 33.0m respectively. East China Sea Bridge starts from Nanhui District, Shanghai and extends to the Yangshan Deep Water Port Area, which is located at one of the Qiqu Islands. The total length of the bridge is about 31.0 km, in which 25 km are on the sea, and 22 km is in the unnavigable region. Hangzhou Bay Bridge across the mouth of Qiantang River.

  10. Is myocardial bridging a bridge connecting to cardiovascular events?

    Institute of Scientific and Technical Information of China (English)

    LI Jian-jun

    2010-01-01

    @@ Coronary arteries and their major branches usually course on the surface of the heart in the subepicardial tissue. However, a muscle hber overlying the intramyocardial segment of an epicardial coronary artery was defined as myocardial bridging (MB), and subsequently the artery coursing within the myocardium is called a tunneled artery.

  11. Correlates of Awareness of and Willingness to Use Pre-exposure Prophylaxis (PrEP) in Gay, Bisexual, and Other Men Who Have Sex with Men Who Use Geosocial-Networking Smartphone Applications in New York City.

    Science.gov (United States)

    Goedel, William C; Halkitis, Perry N; Greene, Richard E; Duncan, Dustin T

    2016-07-01

    Geosocial-networking smartphone applications are commonly used by gay, bisexual, and other men who have sex with men (MSM) to meet sexual partners. The purpose of the current study was to evaluate awareness of and willingness to use pre-exposure prophylaxis (PrEP) among MSM who use geosocial-networking smartphone applications residing in New York City. Recruitment utilizing broadcast advertisements on a popular smartphone application for MSM yielded a sample of 152 HIV-uninfected MSM. Multivariable models were used to assess demographic and behavioral correlates of awareness of and willingness to use PrEP. Most participants (85.5 %) had heard about PrEP but few (9.2 %) reported current use. Unwillingness to use PrEP was associated with concerns about side effects (PR = 0.303; 95 % CI 0.130, 0.708; p = 0.006). Given that more than half (57.6 %) of participants were willing to use PrEP, future research is needed to elucidate both individual and structural barriers to PrEP use among MSM.

  12. A Model for Collaborative Laboratory Experiences between Higher Education and a High School Technical Preparation Program: Promoting Higher Education, Mentoring, and Research

    Science.gov (United States)

    Otterstetter, Ronald; Buser, Stacey; Kappler, Rachele; Herold, Kelly; Mullet, Nicole; Mullins, Nicole

    2011-01-01

    The Department of Sport Science and Wellness Education (SSWE) and the Athletic Health Care Technical Preparation (Tech Prep) Program (AHCTP) at The University of Akron (UA) are successfully fostering collaboration among a number of different entities (faculty members, allied health professionals, and undergraduate, graduate, and high school…

  13. Cervical histology after routine ThinPrep or SurePath liquid-based cytology and computer-assisted reading in Denmark

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Rask, Johanne; van Ballegooijen, Marjolein;

    2015-01-01

    BACKGROUND: We compared the sensitivity and specificity of liquid-based cytology (LBC) and computer-assisted reading for SurePath/FocalPoint and ThinPrep with those of manually read conventional cytology in routine cervical screening in four Danish laboratories. METHODS: Using data from five...... nationwide registers, technological phases were identified by slide preparation, reading technique, and triage of borderline cytology. Trends in the detection of cervical intraepithelial neoplasia (CIN) were an indicator of the technology's relative sensitivity, and trends in false-positive tests...... an indicator of relative specificity. RESULTS: At 23-29 years, SurePath/FocalPoint statistically significantly increased the detection of ⩾CIN3 by 85% compared with manually read conventional cytology. The 11% increase with ThinPrep was not significant. At 30-44 years, the increase with Sure...

  14. Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study.

    Science.gov (United States)

    Schledermann, Doris; Hyldebrandt, Tina; Ejersbo, Dorthe; Hoelund, Berit

    2007-06-01

    The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening procedure was timed for each of the 11,354 slides included. In every slide 22 fields of view were reviewed, and the samples that contained potentially abnormal cells were fully screened. The screening time was reduced by 42% (mean) (p < 0.001). By manual rescreening of the negative TIS samples, abnormal cells were found in 10 samples (false negative rate 0.14%). In every case the abnormal cells had been identified by the scanner, but misinterpreted by the cytotechnologist. These findings stressed the importance of carefulness in the interpretation of the marked fields and beyond that helped the cytotechnologists and pathologists to have more confidence in the automated system.

  15. A case study of chewed Truvada(®) for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

    Science.gov (United States)

    Lalley-Chareczko, Linden; Clark, Devon; Zuppa, Athena F; Moorthy, Ganesh; Conyngham, Caitlin; Mounzer, Karam; Koenig, Helen

    2017-03-06

    FTC/TDF (Truvada®) given as pre-exposure prophylaxis (PrEP) successfully blocks HIV when taken once daily prior to potential HIV exposure. A 22 year old male reported difficulty swallowing FTC/TDF for PrEP and subsequently began chewing the FTC/TDF tablets. Monthly urine samples assessed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) indicated tenofovir levels >1000 ng/mL, indicative of protection from HIV acquisition, over a 48 week period. Data from observational studies of HIV positive patients details the successful treatment of HIV using crushed FTC/TDF delivered via feeding and gastronomy tubes while small, randomized trials of healthy volunteers demonstrate bioequivalence between whole and crushed FTC/TDF.

  16. The Wien Bridge Oscillator Family

    DEFF Research Database (Denmark)

    Lindberg, Erik

    2006-01-01

    A tutorial in which the Wien bridge family of oscillators is defined and investigated. Oscillators which do not fit into the Barkhausen criterion topology may be designed. A design procedure based on initial complex pole quality factor is reported. The dynamic transfer characteristic...

  17. Noise Considerations in Resistance Bridges

    DEFF Research Database (Denmark)

    Diamond, Joseph M.

    1963-01-01

    A signal-to-noise analysis is made of the Wheatstone bridge, where the unknown and standard resistors may be at different temperatures, a situation which occurs in resistance thermometry. The limiting condition is assumed to be dissipation in the unknown resistor. It is shown that the ratio arms ...

  18. Intercellular bridges in vertebrate gastrulation.

    Directory of Open Access Journals (Sweden)

    Luca Caneparo

    Full Text Available The developing zebrafish embryo has been the subject of many studies of regional patterning, stereotypical cell movements and changes in cell shape. To better study the morphological features of cells during gastrulation, we generated mosaic embryos expressing membrane attached Dendra2 to highlight cellular boundaries. We find that intercellular bridges join a significant fraction of epiblast cells in the zebrafish embryo, reaching several cell diameters in length and spanning across different regions of the developing embryos. These intercellular bridges are distinct from the cellular protrusions previously reported as extending from hypoblast cells (1-2 cellular diameters in length or epiblast cells (which were shorter. Most of the intercellular bridges were formed at pre-gastrula stages by the daughters of a dividing cell maintaining a membrane tether as they move apart after mitosis. These intercellular bridges persist during gastrulation and can mediate the transfer of proteins between distant cells. These findings reveal a surprising feature of the cellular landscape in zebrafish embryos and open new possibilities for cell-cell communication during gastrulation, with implications for modeling, cellular mechanics, and morphogenetic signaling.

  19. A Rapidly Deployable Bridge System

    Science.gov (United States)

    2013-01-15

    A Rapidly Deployable Bridge System Gareth R. Thomas1 and Bernard J. Sia2 1ATA Engineering, 11995 El Camino Real, San Diego, CA 92130; PH (858) 480...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) ATA Engineering,11995 El Camino Real,San Diego,CA,92130 8. PERFORMING ORGANIZATION REPORT NUMBER

  20. Architectural engineering of FRP bridges

    OpenAIRE

    Smits, J.E.P.

    2014-01-01

    This paper deals with the use of Fibre Reinforced Polymers (FRP's) in architectural and structural bridge design. The challenges and opportunities that come with this relatively new material are discussed. An inventory is made of recent engineers' solutions in FRP, followed by a discussion on architectural application of FRP's derived from the authors architectural practice.

  1. Bridge Aesthetics and Structural Honesty

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    In bridges the overall form must be chosen with due respect to the transmission of forces if efficient structures shall be created, The design must therefore be governed by experienced structural engineers - in some cases assisted by aesthetic advisers on specific issues. Some basic requirements...

  2. Architectural engineering of FRP bridges

    NARCIS (Netherlands)

    Smits, J.E.P.

    2014-01-01

    This paper deals with the use of Fibre Reinforced Polymers (FRP's) in architectural and structural bridge design. The challenges and opportunities that come with this relatively new material are discussed. An inventory is made of recent engineers' solutions in FRP, followed by a discussion on archit

  3. Vulnerability of bridges to fire

    DEFF Research Database (Denmark)

    Giuliani, Luisa; Crosti, C.; Gentili, F.

    2012-01-01

    , considering both the costs deriving by structural damages and by limited serviceability and other indirect societal aspects. Few cases of recent bridge fire are reviewed in detail and structural consequences are highlighted, distinguishing between damages directly induced by fire and damages induced by local...

  4. The Safety of Tenofovir-Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B.

    Science.gov (United States)

    Solomon, Marc M; Schechter, Mauro; Liu, Albert Y; McManhan, Vanessa M; Guanira, Juan V; Hance, Robert J; Chariyalertsak, Suwat; Mayer, Kenneth H; Grant, Robert M

    2016-03-01

    Pre-exposure prophylaxis (PrEP) with daily oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) prevents HIV infection. The safety and feasibility of HIV PrEP in the setting of hepatitis B virus (HBV) infection were evaluated. The Iniciativa Profilaxis Pre-Exposición study randomized 2499 HIV-negative men and transgender women who have sex with men to once-daily oral FTC/TDF versus placebo. Hepatitis serologies and transaminases were obtained at screening and at the time PrEP was discontinued. HBV DNA was assessed by polymerase chain reaction, and drug resistance was assessed by population sequencing. Vaccination was offered to individuals susceptible to HBV infection. Of the 2499 participants, 12 (0.5%; including 6 randomized to FTC/TDF) had chronic HBV infection. After stopping FTC/TDF, 5 of the 6 participants in the active arm had liver function tests performed at follow-up. Liver function tests remained within normal limits at post-stop visits except for a grade 1 elevation in 1 participant at post-stop week 12 (alanine aminotransferase = 90, aspartate aminotransferase = 61). There was no evidence of hepatic flares. Polymerase chain reaction of stored samples showed that 2 participants in the active arm had evidence of acute HBV infection at enrollment. Both had evidence of grade 4 transaminase elevations with subsequent resolution. Overall, there was no evidence of TDF or FTC resistance among tested genotypes. Of 1633 eligible for vaccination, 1587 (97.2%) received at least 1 vaccine; 1383 (84.7%) completed the series. PrEP can be safely provided to individuals with HBV infection if there is no evidence of cirrhosis or substantial transaminase elevation. HBV vaccination rates at screening were low globally, despite recommendations for its use, yet uptake and efficacy were high when offered.

  5. The Safety of Tenofovir–Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B

    Science.gov (United States)

    Schechter, Mauro; Liu, Albert Y.; McManhan, Vanessa M.; Guanira, Juan V.; Hance, Robert J.; Chariyalertsak, Suwat; Mayer, Kenneth H.; Grant, Robert M.

    2016-01-01

    Background: Pre-exposure prophylaxis (PrEP) with daily oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) prevents HIV infection. The safety and feasibility of HIV PrEP in the setting of hepatitis B virus (HBV) infection were evaluated. Methods: The Iniciativa Profilaxis Pre-Exposición study randomized 2499 HIV-negative men and transgender women who have sex with men to once-daily oral FTC/TDF versus placebo. Hepatitis serologies and transaminases were obtained at screening and at the time PrEP was discontinued. HBV DNA was assessed by polymerase chain reaction, and drug resistance was assessed by population sequencing. Vaccination was offered to individuals susceptible to HBV infection. Results: Of the 2499 participants, 12 (0.5%; including 6 randomized to FTC/TDF) had chronic HBV infection. After stopping FTC/TDF, 5 of the 6 participants in the active arm had liver function tests performed at follow-up. Liver function tests remained within normal limits at post-stop visits except for a grade 1 elevation in 1 participant at post-stop week 12 (alanine aminotransferase = 90, aspartate aminotransferase = 61). There was no evidence of hepatic flares. Polymerase chain reaction of stored samples showed that 2 participants in the active arm had evidence of acute HBV infection at enrollment. Both had evidence of grade 4 transaminase elevations with subsequent resolution. Overall, there was no evidence of TDF or FTC resistance among tested genotypes. Of 1633 eligible for vaccination, 1587 (97.2%) received at least 1 vaccine; 1383 (84.7%) completed the series. Conclusions: PrEP can be safely provided to individuals with HBV infection if there is no evidence of cirrhosis or substantial transaminase elevation. HBV vaccination rates at screening were low globally, despite recommendations for its use, yet uptake and efficacy were high when offered. PMID:26413853

  6. History of cable-stayed bridges

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    The principle of supporting a bridge deck by inclined tension members leading to towers on either side of the span has been known for centuries. However, the real development of cable-stayed bridges did not begin before the 1950s. Since then the free span has been increased from 183 m...... in the Strömsund Bridge (from 1955) to 890 m in the Tatara Bridge (from 1999)....

  7. Field performance of timber bridges. 5, Little Salmon Creek stress-laminated deck bridge

    Science.gov (United States)

    M. A. Ritter; J. A. Kainz; G. J. Porter

    The Little Salmon Creek bridge was constructed in November 1988 on the Allegheny National Forest in Pennsylvania. The bridge is a simple span, single-lane, stress-laminated deck superstructure that is approximately 26-ft long and 16-ft wide. The bridge is unique in that it is the first known stress-laminated timber bridge to be constructed of hardwood lumber. The...

  8. Field performance of timber bridges. 6, Hoffman Run stress-laminated deck bridge

    Science.gov (United States)

    M. A. Ritter; P. D. Hilbrich Lee; G. J. Porter

    The Hoffman Run bridge, located just outside Dahoga, Pennsylvania, was constructed in October 1990. The bridge is a simple-span, single-lane, stress-laminated deck superstructure that is approximately 26 ft long and 16 ft wide. It is the second stress-laminated timber bridge to be constructed of hardwood lumber in Pennsylvania. The performance of the bridge was...

  9. Evaluation of a new preparative supercritical fluid chromatography system for compound library purification: the TharSFC SFC-MS Prep-100 system.

    Science.gov (United States)

    Ebinger, Katalin; Weller, Harold N; Kiplinger, Jeffrey; Lefebvre, Paul

    2011-06-01

    Preparative HPLC-MS is often the method of choice for purification of small amounts (<100mg) of diverse new molecules, such as compound libraries for drug discovery. The method is robust, well proven, and widely applicable. In contrast, preparative supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) has seen only slow acceptance for the same application--despite some potential scientific and economic advantages. One of the reasons for slow adoption of SFC-MS is the lack of well-proven, robust, and commercially available instrumentation. In early 2009, TharSFC (a Waters Company, Pittsburgh, PA) introduced a new fully integrated system for preparative SFC-MS: The SFC-MS Prep-100. We report herein an objective evaluation of the SFC-MS Prep-100, including tests for pump and autosampler performance, sample recovery, sample carryover, fraction triggering, detector/fraction collector synchronization, and overall robustness. Our results suggest that the SFC-MS Prep-100 represents a significant advance over previous generation instrumentation.

  10. Building Bridges One Line at a Time

    Science.gov (United States)

    Grigsby, Cathy Murray

    2012-01-01

    In this article, first-grade students were taught the different kinds of lines that were part of the construction of various bridges--the curved lines of the arches of stone bridges, straight lines connecting the cables of a suspension bridge, vertical lines, horizontal lines, and so on. They gained practice in drawing structures and in fine brush…

  11. Comparison between Modern Violin Bridge and Baroque Violin Bridge by Photoelastic Observation and Frequency Analysis

    Science.gov (United States)

    Matsutani, Akihiro

    2004-05-01

    A comparison between the modern bridge and the baroque bridge of the violin by photoelastic observation was carried out. The relationship between the stress part and the hole is symmetric in the modern and baroque bridges. The measured spectral envelopes of baroque bridges are similar to those of modern bridges in D- or G-strings, and have peaks at a frequency higher than those of modern bridges in E-string. The visualization method as used in this study may provide hints for the design of violin bridges.

  12. Validation of Cobas AmpliPrep/Cobas TaqMan HIV-1 Test on dried blood spots

    Directory of Open Access Journals (Sweden)

    N Ruiz

    2012-11-01

    Full Text Available The plasma specimen is the gold standard for viral load monitoring, the key method to assess the effect of antiviral chemotherapy and to monitor progression of the disease toward AIDS. Nevertheless, several works endorse the use of dried blood spots (DBS on filter paper for the reliable quantification of the levels needed to take therapeutic decisions, detect of treatment failure and monitor the occurrence of drug resistance. The purpose of this study was to validate the use of Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0, with DBS. To evaluate the performance of the above mentioned kit, three stages were involved: 1- Standardization of DBS working conditions, 2- Stability studies at three temperature conditions and 3- Performance evaluation of the kit using this alternative specimen. Additionally, the viral load was quantified in parallel (plasma and DBS to 43 genetically characterized samples, with different levels of viral load. The Pearson correlation coefficient was calculated and the prediction of the value of RNA in plasma starting from the obtained value in DBS was made. Linear regression analysis was performed and coefficients of variation in precision assays were calculated. The best conditions pickups to the work with DBS were: 100 µL of blood (2 spots/50 µl, dried time between 16 and 18 hours at room temperature and, elution of the blood, 2 hours, between 2 and 8°C; in TRIS-EDTA buffer. The samples on DBS proved to be stable during the study periods. A strong correlation was attained between the measurements of viral load in plasma and DBS samples (r=0.96. The detection rate was 90.7 and the coefficient of variation between the values obtained in plasma-DBS sample pairs averaged 3.42%. The CAP/CTM HIV-1 test provided a linear response in DBS, from 330 copies/mL to 420 000 copies/mL. Overall, coefficients of variation in precision tests were below 10%. Cobas AmpliPrep/Cobas TaqMan HIV-1 test version 2.0 had a good

  13. High pre-exposure prophylaxis uptake and early adherence among men who have sex with men and transgender women at risk for HIV Infection: the PrEP Brasil demonstration project.

    Science.gov (United States)

    Hoagland, Brenda; Moreira, Ronaldo I; De Boni, Raquel B; Kallas, Esper G; Madruga, José Valdez; Vasconcelos, Ricardo; Goulart, Silvia; Torres, Thiago S; Marins, Luana M S; Anderson, Peter L; Luz, Paula M; Costa Leite, Iuri da; Liu, Albert Y; Veloso, Valdilea G; Grinsztejn, Beatriz

    2017-04-06

    The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System. HIV-uninfected MSM and TGW in 3 referral centres in Rio de Janeiro and São Paulo were evaluated for eligibility and offered 48 weeks of daily emtricitabine/tenofovir for PrEP. Concentrations of tenofovir diphosphate in dried blood spot samples (DBS) at week 4 after enrolment (early adherence) were measured. Predictors of drug levels were assessed using ordinal logistic regression models considering the DBS drug level as a 3 level variable (<350 fmol/punch, ≥350-699 fmol/punch and ≥700 fmol/punch). 1,270 individuals were assessed for participation; n = 738 were potentially eligible and n = 450 were offered PrEP (PrEP uptake was 60.9%). Eligible but not enrolled individuals were younger, had lower HIV risk perception and had lower PrEP awareness. At week 4, 424 participants (of the 450 enrolled) had DBS TFV-DP concentrations, 94.1% in the protective range (≥350 fmol/punch, consistent with ≥2 pills per week), and 78% were in the highly protective range (≥700 fmol/punch, ≥4 pills per week). Participants with ≥12 years of schooling had 1.9 times the odds (95%CI 1.10-3.29) of a higher versus lower drug level than participants with <12 years of schooling. Condomless receptive anal intercourse in the prior 3 months was also associated with higher drug levels (adjusted OR = 1.78; 95% CI 1.08-2.94). The high uptake and early adherence indicate that PrEP for high-risk MSM and TGW can be successfully delivered in the context of the Brazilian Public Health System. Interventions to

  14. ESTIMATION OF ECONOMIC EXPEDIENCY OF «BRIDGE-PRE-BRIDGE TERRITORY» SYSTEM

    Directory of Open Access Journals (Sweden)

    A. A. Lapko

    2008-01-01

    Full Text Available The paper considers principles that form «Bridge-Pre-Bridge Territory» system. The method is proposed for calculation of expenses on technical research for development of projects on usage of pre-bridge territories. Usage of site class number for natural conditions makes it possible to estimate investment attractiveness of «Bridge-Pre-Bridge Territory» system.

  15. Experimental Study on Shear Lag Effect of Partial Cable-Stayed Bridge and Elasto-Plastic Seismic Analysis

    Institute of Scientific and Technical Information of China (English)

    WU Gao-feng; XU Hong; CHEN Xing-chong

    2005-01-01

    The project of Xiaoxihu Yellow River Bridge in Lanzhou is chosen as partial cable-stayed bridge. To get the shear lag effect and anti-earthquake performance of the actual bridge under various loading conditions, organic glass scaled model was adopted to have an experiment and a theory research at one time. The experiment result is the basically same as the theory calculation which proves the FEA method can well calculate shear lag effect and dynamical performance. As a result, because the bridge is located in a seismic area of 8 degree, an elasto-plastic seismic checking is performed by customized FEA program in this paper.

  16. Diversifying the Midwifery Workforce: Inclusivity, Culturally Sensitive Bridging, and Innovation.

    Science.gov (United States)

    Tyson, Holliday; Wilson-Mitchell, Karline

    2016-11-01

    Midwifery educators and regulators in Canada have begun to address diversity, equity, and inclusion in admission processes and program curricula. Populations served by midwives value internationally educated midwives from their countries of origin. The International Midwifery Pre-Registration Program at Ryerson University in Toronto, Ontario, provides assessment, midwifery workplace orientation, and accelerated education for internationally educated midwives on behalf of the regulatory College of Midwives of Ontario. Between 2003 and 2015, midwives from 41 countries participated in the bridging program, and 214 (80%) successfully completed the program and qualified for licensure. Of these 214 graduates, 100% passed the Canadian Midwifery Registration Examination and 193 (90%) were employed full time as midwives within 4 months of graduation. The program curriculum enables the integration of these midwives into health care workplaces utilizing innovative approaches to assessment and competency enhancement. Critical to the bridging process are simulation-based practices to develop effective psychomotor learning, virtual and real primary care community placements, and coaching in empathetic, client-centered communication. Cultural sensitivity is embedded into the multiple assessment and learning modalities, and addresses relevant barriers faced by immigrant midwives in the workplace. Findings from the 13 years of the program may be applicable to increase diversity in other North American midwifery settings. This article describes the process, content, outcomes, and findings of the program. Midwifery educators and regulators may consider the utility of these approaches for their settings. © 2016 by the American College of Nurse-Midwives.

  17. Beginning Course Surveys: Bridges for Knowing and Bridges for Being

    Directory of Open Access Journals (Sweden)

    David Starr-Glass

    2011-06-01

    Full Text Available The use of a participant survey, administered at the outset of an online course, can provide information useful in the management of the learning environment and in its subsequent redesign. Such information can clarify participants’ prior experience, expectations, and demographics. But the very act of enquiring about the learner also signals the instructor’s social presence, relational interest, and desire to enter into an authentic dialogue. This study examines the use of participant surveys in online management courses. The first section discusses the informational bridges that this instrument provides. The second section considers survey responses to open-ended questions dealing with student sentiments. This analysis suggests that the survey plays a valuable part in accentuating social presence and in initiating relational bridges with participants.

  18. 33 CFR 115.70 - Advance approval of bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges...

  19. Marine ARM GPCI Investigation of Clouds Bridge Display Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, R. Michael [Remote Measurements & Research Company, Seattle, WA (United States); Lewis, Ernie [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-09-01

    At the beginning of the U.S. Department of Energy (DOE) Marine Atmospheric Radiation Measurement (ARM) Climate Research Facility Global Energy and Water Experiment (GEWEX) Cloud System Study (GCSS) Pacific Cross-Section Intercomparison (GPCI) Investigation of Clouds (MAGIC) experiment, we recognized that the crew on the ship’s bridge would like to see a display of the meteorological data that was being collected. While a display on the bridge would be marginally useful to the science, it was decided to make a display for the bridge. A display was programmed in Lab View and a personal computer (PC) was set up in the bridge. This remained in operation until the ship went to dry dock for upgrades and service. Part of the upgrade was a new meteorological system for the ship. After this time there was no need for the ARM display and so it was not re-installed for the remainder of the program.

  20. Thermal Bridges in Building Construction - Measurements and Calculations

    DEFF Research Database (Denmark)

    Rose, Jørgen

    in building envelope constructions is given. After this a validation of both programs and guidelines is presented. The validation is performed by comparing calculated U-values with Guarded Hot Box measurements. The last part of the thesis discusses the possibilities of utilising the results of detailed...... calculations in more operational and applicable projecting tools, e.g. thermal bridge catalogues or U-value tables....

  1. Shear Reinforcement Requirements for High-Strength Concrete Bridge Girders

    OpenAIRE

    Ramirez, J. A.; Aguilar, Gerardo

    2005-01-01

    A research program was conducted on the shear strength of high-strength concrete members. The objective was to evaluate the shear behavior and strength of concrete bridge members with compressive strengths in the range of 10 000 to 15 000 psi. The goal was to determine if the current minimum amount of shear reinforcement together with maximum spacing limits in the 2004 AASHTO LRFD Specifications, and the upper limit on the nominal shear strength were applicable to concrete compressive strengt...

  2. Performance analysis of LAN bridges and routers

    Science.gov (United States)

    Hajare, Ankur R.

    1991-01-01

    Bridges and routers are used to interconnect Local Area Networks (LANs). The performance of these devices is important since they can become bottlenecks in large multi-segment networks. Performance metrics and test methodology for bridges and routers were not standardized. Performance data reported by vendors is not applicable to the actual scenarios encountered in an operational network. However, vendor-provided data can be used to calibrate models of bridges and routers that, along with other models, yield performance data for a network. Several tools are available for modeling bridges and routers - Network II.5 was used. The results of the analysis of some bridges and routers are presented.

  3. A Walk in Our Shoes: A Discussion of Relevance and Communication in Teacher Prep

    Science.gov (United States)

    Goldman, Karen L.; Cardell, Melanie

    2013-01-01

    Relevance is discussed in light of 21st c. communication skills and relevance. How do these areas impact both the face-to-face and online candidates in the MAT and MAED programs to positively impact P-12 students? Relevance theory and communication in 21st c. is clarified for working in both face-to-face and online learning environments leading…

  4. BIOTECON diagnostics foodproof Listeria monocytogenes Detection Kit, 5' nuclease in combination with the foodproof ShortPrep II Kit.

    Science.gov (United States)

    Junge, Benjamin; Grönewald, Cordt; Berghof-Jäger, Kornelia

    2012-01-01

    A method was developed for the detection of Listeria monocytogenes in food. The method is based on real-time PCR using hydrolysis probes (5' Nuclease). This advanced PCR method was designed to reduce the time necessary to achieve results from PCR reactions and to enable the user to monitor the amplification of the PCR product simultaneously, in real-time. After DNA isolation using the BIOTECON foodproof ShortPrep II Kit designed for the rapid preparation of L. monocytogenes DNA for direct use in PCR, the real-time detection of L. monocytogenes DNA is carried out using the foodproof Listeria monocytogenes Detection Kit. The kit provides primers and hydrolysis probes for sequence-specific detection, convenient premixed reagents, and controls for reliable interpretation of results. For the internal comparison study, three different foods (soft cheese, coalfish, and smoked ham) were analyzed, chosen from the 15 food groups recommended by the AOAC Research Institute for detection of L. monocytogenes. From each food, 20 samples were inoculated with a low level (1-10 CFU/25 g) and 20 samples with a high level (10-50 CFU/25 g) of L. monocytogenes. Additionally, five nonspiked samples were prepared from each food. Depending on the matrix, the food samples were examined with the test kits and compared with the cultural methods according to the U.S. Food and Drug Administration's Bacteriological Analytical Manual or the U.S. Department of Agriculture/Food Safety and Inspection Service Microbiology Laboratory Guidebook.

  5. Has the ThinPrep method of cervical screening maintained its improvement over conventional smears in terms of specimen adequacy?

    LENUS (Irish Health Repository)

    Treacy, A

    2009-04-01

    Liquid-based cytology (LBC) has replaced conventional smear assessment in many centers over recent years. In our laboratory this transfer took place in 1999. At that time we performed a split sample study comparing the conventional method of cervical smear evaluation with the ThinPrep system. This split sample study identified a dramatic improvement in specimen adequacy with LBC. While 11% of conventional preparations were reported as unsatisfactory and almost 9% were reported as suboptimal, evaluation of the same cases using LBC saw this combined figure reduced to 2.3%. AIM: To evaluate whether this dramatic fall in unsatisfactory smears has been maintained with the use of LBC. The database for all smears reported for 2005 (100% LBC) was interrogated. The number of unsatisfactory reports was calculated. The reason for an unsatisfactory report was recorded for each case. The overall unsatisfactory rate was compared with that reported in the 1999 split sample study. A total of 41,312 smear tests were reported in 2005. 1,342 (3.25%) were reported as unsatisfactory. Our findings support the ongoing value of LBC in a routine cervical screening laboratory in terms of continuing to maintain a low rate of unsatisfactory smears.

  6. Preliminary study of a new, fully automated system for liquid-based cytology: the NovaPrep® processor system.

    Science.gov (United States)

    Esquivias López-Cuervo, Javier; Montalbán Beltran, Estanislao; Cuadros Lopez, Jose Luis; Alonso Castillo, Angeles; Nieto Sanchez, Teresa

    2011-01-01

    To evaluate a fully automated system for liquid-based cytology (LBC): the NovaPrep® Processor System (NPS), which is based on the new concept of double decantation, versus conventional cytology (CC), the gold standard for cytology. We performed a preliminary comparative study involving 1,129 female patients who underwent sampling for a Pap test; the sample was first smeared for CC and then, using the remaining specimen on the brush, for LBC with the NPS. The performances of CC and NPS were evaluated for accuracy and compared using the gold standard of a combination of one of the two methods of pathological cytology with screening for positive human papilloma virus, quantification of cells (normal and pathological), and improvement in the quality of samples and reading time. The results showed improvement in sensitivity (3.81% for CC vs. 4.52% for NPS) with a specificity superior to 90% for both, a markedly decreased number of unsatisfactory specimens, notably samples containing too many inflamed cells (7.4% for CC vs. 0.5% for NPS), and a shortening of the reading time, which was three times less using NPS. This preliminary study showed a gain in sensitivity, a drop in the number of unsatisfactory specimens and a reduction in reading time with NPS. The results achieved using this fully automated LBC procedure are very promising and will hopefully reduce the overall cost of cervical cancer screening in the future. Copyright © 2011 S. Karger AG, Basel.

  7. Problems associated with nondestructive evaluation of bridges

    Science.gov (United States)

    Prine, David W.

    1995-05-01

    The US has 542,000 bridges that consume billions of dollars per year in construction, rehabilitation, and maintenance funds and which are the lifelines of US commerce. The 1992 ISTEA (Intermodal Surface Transportation Efficiency Act) mandates the implementation of a quantitative computerized bridge management system by 1996. A prime need of such a system are quantitative bridge inspection methods to feed accurate reliable condition information to the huge database of bridges. Nondestructive evaluation (NDE) will fill a critical need in the implementation of effective bridge management. However, many serious barriers exist to the widespread routine application of this technology to bridges. This paper provides an overview of the typical problems associated with applying NDE to bridges.

  8. Protocol for an open-label, single-arm trial of HIV pre-exposure prophylaxis (PrEP) among people at high risk of HIV infection: the NSW Demonstration Project PRELUDE

    Science.gov (United States)

    Vaccher, S; Grulich, A; McAllister, J; Templeton, D J; Bloch, M; McNulty, A; Holden, J; Poynten, I M; Prestage, G; Zablotska, I

    2016-01-01

    Introduction Despite a number of HIV prevention strategies, the number of new HIV infections remains high. In Australia, over three-quarters of new HIV diagnoses are in gay and bisexual men (GBM). Pre-exposure prophylaxis (PrEP) has been shown to be effective at preventing new HIV infections in several randomised trials. The PRELUDE study aims to evaluate the implementation of PrEP in healthcare settings in New South Wales (NSW), Australia, among a sample of high-risk adults. Methods and analysis PRELUDE is an ongoing open-label, single-arm demonstration project, conducted in public and private clinics across NSW, Australia. Enrolment began in November 2014. The study is designed for 300 high-risk participants—mainly GBM and heterosexual women. Participants receive daily oral PrEP, composed of emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF), for up to 2.5 years. Quarterly study visits include testing for HIV and sexually transmitted infections (STIs), assessment of ongoing eligibility and side effects, and self-reported adherence. Following each study visit, online behavioural surveys are administered to collect information on medication adherence, risk behaviours and attitudes. Blood samples will be collected in a subset of patients 1, 6 and 12 months after PrEP initiation to measure FTC/TDF concentrations. Analyses using longitudinal regression models will focus on feasibility, adherence, safety, tolerability and effects of PrEP on behaviour. This study will inform PrEP policy and guide the implementation of PrEP in Australia in people at high risk of HIV. Ethics and dissemination The study will be conducted in accordance with the Declaration of Helsinki. All patients will provide written informed consent prior to participation in the study. Publications relating to each of the primary end points will be gradually released after 12 months of follow-up is complete. Trial registration number NCT02206555; Pre-results. PMID:27324719

  9. CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

    Science.gov (United States)

    Rudolph, Alexander L.; Smecker-Hane, Tammy A.

    2017-01-01

    We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field.In 7 years, the CAMPARE program has sent 80 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. The graduation rate among CAMPARE scholars is 98%, and of the CAMPARE scholars who have graduated with a Bachelor’s degree, more than 60% have completed or are pursuing graduate education in astronomy or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, and the Fisk-Vanderbilt Master’s-to-PhD program.Now entering its third year, the Cal-Bridge program is a CSU-UC Bridge program comprised of over 75 physics and astronomy faculty from 5 University of California (UC), 9 California State University (CSU), and 14 California Community College (CCC) campuses in Southern California. In the first three years, 22 Cal-Bridge Scholars have been selected, including 11 Hispanic, 3 African-American and 8 female students, 5 of whom are from URM groups. Nineteen (19) of the 22 Cal-Bridge Scholars are first-generation college students. The entire first cohort of 4 Cal-Bridge scholars was accepted to one or more PhD programs in astronomy or physics, including UC Irvine, UC Santa Cruz, UC Davis, Michigan State, and Georgia State Universities. The second cohort of 8 Cal-Bridge scholars is applying to graduate schools this fall.Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher

  10. Severe ASR damaged concrete bridges

    DEFF Research Database (Denmark)

    Antonio Barbosa, Ricardo; Gustenhoff Hansen, Søren

    2015-01-01

    Technical University of Denmark (DTU) and University of Southern Denmark (SDU) have conducted several full-scale experiments with severe ASR deteriorated bridges. This paper presents few and preliminary results from both the shear tests and the measuring of the material properties. The shear test...... show that the shear capacity is almost unaffected of ASR despite significant reduction in compressive concrete strength. Furthermore, measurements show a significant tensile reinforcement strain developed due to ASR expansion....

  11. Inspection Strategies for Concrete Bridges

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    1989-01-01

    In this paper an optimal inspection strategy for concrete bridges based on periodic routine and detailed inspections is presented. The failure mode considered is corrosion of the reinforcement due to chlorides. A simple modelling of the corrosion and of the inspection strategy is presented....... The optimal inspection strategy is determined from an optimization problem, where the design variables are time intervals between detailed inspections and the concrete cover. The strategy is illustrated on a simple structure, namely a reinforced concrete beam....

  12. Inspection Strategies for Concrete Bridges

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    1989-01-01

    In this paper an optimal inspection strategy for concrete bridges based on periodic routine and detailed inspections is presented. The failure mode considered is corrosion of the reinforcement due to chlorides. A simple modelling of the corrosion and of the inspection strategy is presented....... The optimal inspection strategy is determined from an optimization problem, where the design variables are time intervals between detailed inspections and the concrete cover. The strategy is illustrated on a simple structure, namely a reinforced concrete beam....

  13. Parabolic metamaterials and Dirac bridges

    Science.gov (United States)

    Colquitt, D. J.; Movchan, N. V.; Movchan, A. B.

    2016-10-01

    A new class of multi-scale structures, referred to as `parabolic metamaterials' is introduced and studied in this paper. For an elastic two-dimensional triangular lattice, we identify dynamic regimes, which corresponds to so-called `Dirac Bridges' on the dispersion surfaces. Such regimes lead to a highly localised and focussed unidirectional beam when the lattice is excited. We also show that the flexural rigidities of elastic ligaments are essential in establishing the `parabolic metamaterial' regimes.

  14. Cross-Quint-Bridge Resistor

    Science.gov (United States)

    Hannaman, David J.; Lieneweg, Udo; Buehler, Martin G.; Mantalas, Linda

    1991-01-01

    Integrated-circuit conductive test pattern intended to provide data on effects of design widths and design spacings upon actual widths of conductive lines. Provides for electrical measurements both on lines of unknown width and on features having known dimensions. Data from measurements on five bridges used to determine four parameters of mathematical model describing system. In principle, pattern determines effects of width and spacing and interaction between them.

  15. Cochleates bridged by drug molecules.

    Science.gov (United States)

    Syed, Uwais M; Woo, Amy F; Plakogiannis, Fotios; Jin, Tuo; Zhu, Hua

    2008-11-03

    A new type of cochleate, able to microencapsulate water-soluble cationic drugs or peptides into its inter-lipid bi-layer space, was formed through interaction between negatively charged lipids and drugs or peptides acting as the inter-bi-layer bridges instead of multi-cationic metal ions. This new type of cochleate opened up to form large liposomes when treated with EDTA, suggesting that cationic organic molecules can be extracted from these cochleates in a way similar to multivalent metal ions from metal ion-bridged cochleates. Cochleates can be produced in sub-micron size using a method known as "hydrogel isolated cochleation" or simply by increasing the ratio of multivalent cationic peptides over negatively charged liposomes. When nanometer-sized cochleates and liposomes containing the same fluorescent labeled lipid component were incubated with human fibroblasts cells under identical conditions, cells exposed to cochleates showed bright fluorescent cell surfaces, whereas those incubated with liposomes did not. This result suggests that cochleates' edges made them fuse with the cell surfaces as compared to edge free liposomes. This mechanism of cochleates' fusion with cell membrane was supported by a bactericidal activity assay using tobramycin cochleates, which act by inhibiting intracellular ribosomes. Tobramycin bridged cochleates in nanometer size showed improved antibacterial activity than the drug's solution.

  16. Halliburton Composite Bridge Plug Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Starbuck, J.M.; Luttrell, C.R.; Aramayo, G.

    2005-01-15

    The overall objectives of this CRADA were to assist Halliburton in analyzing a composite bridge plug and to determine why their original design was failing in the field. In Phase 1, finite element analyses were done on the original composite slip design and several alternative designs. The composite slip was the component in the bridge plug that was failing. The finite element code ABAQUS was used for these calculations and I-DEAS was used as the pre- and post-processor in the analyses. Several different designs and materials were analyzed and recommendations were made towards improving the design. In Phase 2, the objective was to develop finite element models that would accurately represent the deformations in the entire all-composite 4-1/2' diameter bridge plug assembly. The finite element code LS-DYNA was used and the results from this effort were intended to expand Halliburton's composite design and analysis capabilities with regard to developing future composite components for downhole tools. In addition to the finite element modeling, this effort involved the utilization of micromechanics to determine the necessary composite material properties that were needed as input for finite element codes.

  17. A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

    NARCIS (Netherlands)

    Retel, Valesca P.; van der Molen, Lisette; Steuten, Lotte Maria Gertruda; van den Brekel, Michiel W.; Hilgers, Frans J.

    2016-01-01

    Previous studies have shown that a “Preventive Exercise Program” (PREP) is cost-effective compared to the standard exercise program provided in “Usual Care” (UC) in patients with advanced head and neck cancer. The current paper specifically estimates the cost-effectiveness of the TheraBite jaw

  18. The Bridge Project: Connecting Home, School, and Community for Mexican Immigrant Children

    Science.gov (United States)

    McElvain, Cheryl Marie

    2015-01-01

    This study examines the academic and psychosocial effects of the Bridge Project after-school program on 25 prekindergarten through 6th-grade English language learner Mexican immigrant children and their families living in an affordable housing complex in the San Francisco Bay Area. The results of the study show that the program increased the…

  19. The Bridge Project: Connecting Home, School, and Community for Mexican Immigrant Children

    Science.gov (United States)

    McElvain, Cheryl Marie

    2015-01-01

    This study examines the academic and psychosocial effects of the Bridge Project after-school program on 25 prekindergarten through 6th-grade English language learner Mexican immigrant children and their families living in an affordable housing complex in the San Francisco Bay Area. The results of the study show that the program increased the…

  20. Experimental and Numerical Study on Modal Dynamic Response of Water-Surrounded Slender Bridge Pier with Pile Foundation

    National Research Council Canada - National Science Library

    Yulin Deng; Qingkang Guo; Lueqin Xu

    2017-01-01

      This paper presents an experimental program performed to study the effect of fluid-structure interaction on the modal dynamic response of water-surrounded slender bridge pier with pile foundation...

  1. Comprehensive Geriatric Assessment and Transitional Care in Acutely Hospitalized Patients The Transitional Care Bridge Randomized Clinical Trial

    NARCIS (Netherlands)

    Buurman, Bianca M.; Parlevliet, Juliette L.; Allore, Heather G.; Blok, Willem; van Deelen, Bob A. J.; van Charante, Eric P. Moll; de Haan, Rob J.; de Rooij, Sophia E.

    2016-01-01

    IMPORTANCE Older adults acutely hospitalized are at risk of disability. Trials on comprehensive geriatric assessment (CGA) and transitional care present inconsistent results. OBJECTIVE To test whether an intervention of systematic CGA, followed by the transitional care bridge program, improved activ

  2. Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk

    Directory of Open Access Journals (Sweden)

    James Wilton

    2016-06-01

    Full Text Available Introduction: Identifying appropriate pre-exposure prophylaxis (PrEP candidates is a challenge in planning for the safe and effective roll-out of this strategy. We explored the use of a validated HIV risk screening tool, HIV Incidence Risk Index for Men who have Sex with Men (HIRI-MSM, to identify “optimal” candidates among MSM testing at a busy sexual health clinic's community testing sites in Toronto, Canada. Methods: Between November 2014 and April 2015, we surveyed MSM undergoing anonymous HIV testing at community testing sites in Toronto, Canada, to quantify “optimal” candidates for scaling up PrEP roll-out, defined as being at high objective HIV risk (scoring ≥10 on the HIRI-MSM, perceiving oneself at moderate-to-high HIV risk and being willing to use PrEP. Cascades were constructed to identify barriers to broader PrEP uptake. The association between HIRI-MSM score and both willingness to use PrEP and perceived HIV risk were explored in separate multivariable logistic regression analyses. Results: Of 420 respondents, 64.4% were objectively at high risk, 52.5% were willing to use PrEP and 27.2% perceived themselves at moderate-to-high HIV risk. Only 16.4% were “optimal” candidates. Higher HIRI-MSM scores were positively associated with both willingness to use PrEP (aOR=1.7 per 10 score increase, 95%CI=1.3–2.2 and moderate-to-high perceived HIV risk (aOR=1.7 per 10 score increase, 95%CI=1.2–2.3. The proportion of men who were “optimal” candidates increased to 42.9% when the objective HIV risk cut-off was changed to top quartile of HIRI-MSM scores (≥26. In our full cascade, a very low proportion (5.3% of MSM surveyed could potentially benefit from PrEP under current conditions. The greatest barrier in the cascade was low perception of HIV risk among high-risk men, but considerable numbers were also lost in downstream cascade steps. Of men at high objective HIV risk, 68.3% did not perceive themselves to be at moderate

  3. Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk.

    Science.gov (United States)

    Wilton, James; Kain, Taylor; Fowler, Shawn; Hart, Trevor A; Grennan, Troy; Maxwell, John; Tan, Darrell Hs

    2016-01-01

    Identifying appropriate pre-exposure prophylaxis (PrEP) candidates is a challenge in planning for the safe and effective roll-out of this strategy. We explored the use of a validated HIV risk screening tool, HIV Incidence Risk Index for Men who have Sex with Men (HIRI-MSM), to identify "optimal" candidates among MSM testing at a busy sexual health clinic's community testing sites in Toronto, Canada. Between November 2014 and April 2015, we surveyed MSM undergoing anonymous HIV testing at community testing sites in Toronto, Canada, to quantify "optimal" candidates for scaling up PrEP roll-out, defined as being at high objective HIV risk (scoring ≥10 on the HIRI-MSM), perceiving oneself at moderate-to-high HIV risk and being willing to use PrEP. Cascades were constructed to identify barriers to broader PrEP uptake. The association between HIRI-MSM score and both willingness to use PrEP and perceived HIV risk were explored in separate multivariable logistic regression analyses. Of 420 respondents, 64.4% were objectively at high risk, 52.5% were willing to use PrEP and 27.2% perceived themselves at moderate-to-high HIV risk. Only 16.4% were "optimal" candidates. Higher HIRI-MSM scores were positively associated with both willingness to use PrEP (aOR=1.7 per 10 score increase, 95%CI=1.3-2.2) and moderate-to-high perceived HIV risk (aOR=1.7 per 10 score increase, 95%CI=1.2-2.3). The proportion of men who were "optimal" candidates increased to 42.9% when the objective HIV risk cut-off was changed to top quartile of HIRI-MSM scores (≥26). In our full cascade, a very low proportion (5.3%) of MSM surveyed could potentially benefit from PrEP under current conditions. The greatest barrier in the cascade was low perception of HIV risk among high-risk men, but considerable numbers were also lost in downstream cascade steps. Of men at high objective HIV risk, 68.3% did not perceive themselves to be at moderate-to-high HIV risk, 23.6% were unaware of PrEP, 40.1% were not

  4. Salt bridges: geometrically specific, designable interactions.

    Science.gov (United States)

    Donald, Jason E; Kulp, Daniel W; DeGrado, William F

    2011-03-01

    Salt bridges occur frequently in proteins, providing conformational specificity and contributing to molecular recognition and catalysis. We present a comprehensive analysis of these interactions in protein structures by surveying a large database of protein structures. Salt bridges between Asp or Glu and His, Arg, or Lys display extremely well-defined geometric preferences. Several previously observed preferences are confirmed, and others that were previously unrecognized are discovered. Salt bridges are explored for their preferences for different separations in sequence and in space, geometric preferences within proteins and at protein-protein interfaces, co-operativity in networked salt bridges, inclusion within metal-binding sites, preference for acidic electrons, apparent conformational side chain entropy reduction on formation, and degree of burial. Salt bridges occur far more frequently between residues at close than distant sequence separations, but, at close distances, there remain strong preferences for salt bridges at specific separations. Specific types of complex salt bridges, involving three or more members, are also discovered. As we observe a strong relationship between the propensity to form a salt bridge and the placement of salt-bridging residues in protein sequences, we discuss the role that salt bridges might play in kinetically influencing protein folding and thermodynamically stabilizing the native conformation. We also develop a quantitative method to select appropriate crystal structure resolution and B-factor cutoffs. Detailed knowledge of these geometric and sequence dependences should aid de novo design and prediction algorithms.

  5. Bridging the digital divide: reaching vulnerable populations.

    Science.gov (United States)

    Chang, Betty L; Bakken, Suzanne; Brown, S Scott; Houston, Thomas K; Kreps, Gary L; Kukafka, Rita; Safran, Charles; Stavri, P Zoe

    2004-01-01

    The AMIA 2003 Spring Congress entitled "Bridging the Digital Divide: Informatics and Vulnerable Populations" convened 178 experts including medical informaticians, health care professionals, government leaders, policy makers, researchers, health care industry leaders, consumer advocates, and others specializing in health care provision to underserved populations. The primary objective of this working congress was to develop a framework for a national agenda in information and communication technology to enhance the health and health care of underserved populations. Discussions during four tracks addressed issues and trends in information and communication technologies for underserved populations, strategies learned from successful programs, evaluation methodologies for measuring the impact of informatics, and dissemination of information for replication of successful programs. Each track addressed current status, ideal state, barriers, strategies, and recommendations. Recommendations of the breakout sessions were summarized under the overarching themes of Policy, Funding, Research, and Education and Training. The general recommendations emphasized four key themes: revision in payment and reimbursement policies, integration of health care standards, partnerships as the key to success, and broad dissemination of findings including specific feedback to target populations and other key stakeholders.

  6. Evaluation method research on prestressed concrete bridges

    Institute of Scientific and Technical Information of China (English)

    HUANG Qiao; LIN Yang-zi; REN Yuan

    2008-01-01

    Considering the construction features of prestressed concrete bridge, the comprehensive evaluation method about the bridge damage conditions are studied. Particular attentions are paid on establishing a multi-level evaluation model for damaged prestressed concrete bridge, and the evaluation indices of the model as well as the rating standards are defined in the model. A normal relative function about the evaluation indices of each element is developed to calculate the relative degree, and for each element which is no sub-level elements. When evaluating the elements in sub-item level or index level of the model, the weights of elements that are pertained to one element are adopted, taking account of their deterioration degree. At the same time, the dam-age conditions of bridge are characterized by relative degree, element evaluation scale and structural technology mark of bridge ,so it agrees with Code for Maintenance of Highway Bridges and Culvers.

  7. Study on structural system of Sutong Bridge

    Institute of Scientific and Technical Information of China (English)

    Zhang Xigang; Pei Minshan; Yuan Hong; Xu Liping; Zhu Bin

    2009-01-01

    Sutong Bridge, whose layout is [ (100 + 100 + 300) + 1 088 + ( 300 + 100 + 100) ] m, marks the largest span of cable-stayed bridges in the world. The complex natural condition at the bridge site and the strict requirements for resistance of wind and seismic action make it crucial to choose a favorable structural system to assure the function and safety of the bridge. The comparison among several optional structural systems for Sutong Bridge is illustrated. After detailed analysis is carried out for viscous damper and hydraulic buffer, super liquid viscous damper with additional displacement limitation is designed for the first application in bridge engineering. The parameters for the damper is analyzed and studied and the dampers are installed suecessfuUy after quality tests.

  8. Impact of temperature and programming method on the data retention of Cu/Al2O3-based conductive-bridge RAM operated at low-current (10 μA)

    Science.gov (United States)

    Belmonte, A.; Fantini, A.; Redolfi, A.; Houssa, M.; Jurczak, M.; Goux, L.

    2016-11-01

    In this paper we outline the effects on the memory window of the programming method and pulse width and of the temperature, in Cu/Al2O3-based CBRAM targeting a 10-μA current regime. Despite its large median value, the overall HRS/LRS ratio in these devices can be drastically reduced due to the LRS and HRS dispersion and to the instability of the resistive states over time, especially in a low-current regime. For this reason, in this study we adopt a statistical approach, focusing on the tails of the cumulative distribution Function (CDF). We compare different verify-based algorithms to force an initial tail-to-tail (1st percentile of CDF) resistive window, demonstrating that, in order to reduce the total programming time, a complete Write/Erase cycle must be performed at each verify attempt. We also prove that the stability of the programmed LRS/HRS states is strongly influenced by the external temperature and that it is affected by the programming pulse width (PW) used in the algorithm, likely driving the diffusion processes that originate the state degradation. Selecting the appropriate PW, no overlap of the LRS and HRS distributions is observed after 1 week at room temperature.

  9. Influence of central buckle on suspension bridge dynamic characteristics and driving comfort

    Institute of Scientific and Technical Information of China (English)

    王达; 邓扬; 刘扬

    2015-01-01

    The central buckle, which is often used in a suspension bridge, can improve bridges’ performance in the actual operation condition. The influence of the central buckle on natural vibration characteristics and bridge-deck driving comfort of a long-span suspension bridge is studied by using a case study of Siduhe Suspension Bridge in China. Based on the finite element software ANSYS and independently complied program, the influence of the central buckle on the structure force-applied characteristics of a long-span suspension bridge has been explored. The results show that the huge increases of natural frequencies can result in the presence of central buckles because of the increases of bending and torsional rigidities. The central buckle basically makes the stiffening girders and cables within the triangular area covered as a relatively approximate rigid area. Hence, the central buckle can reduce the torsional displacement of the main girder. However, the increases of bending and torsional rigidities have little influence on the impact factor, which is obtained by using vehicle-bridge coupled vibration analysis. This means that the central buckle has little effect on the comfort indices. In addition, it is found that the central buckle can enhance the bridge deck’s driving stability due to the decrease of the torsional displacements of the main girder.

  10. SIMMEON-Prep study: SIMulation of Medication Errors in ONcology: prevention of antineoplastic preparation errors.

    Science.gov (United States)

    Sarfati, L; Ranchon, F; Vantard, N; Schwiertz, V; Gauthier, N; He, S; Kiouris, E; Gourc-Berthod, C; Guédat, M G; Alloux, C; Gustin, M-P; You, B; Trillet-Lenoir, V; Freyer, G; Rioufol, C

    2015-02-01

    Medication errors (ME) in oncology are known to cause serious iatrogenic complications. However, MEs still occur at each step in the anticancer chemotherapy process, particularly when injections are prepared in the hospital pharmacy. This study assessed whether a ME simulation program would help prevent ME-associated iatrogenic complications. The 5-month prospective study, consisting of three phases, was undertaken in the centralized pharmaceutical unit of a university hospital of Lyon, France. During the first simulation phase, 25 instruction sheets each containing one simulated error were inserted among various instruction sheets issued to blinded technicians. The second phase consisted of activity aimed at raising pharmacy technicians' awareness of risk of medication errors associated with antineoplastic drugs. The third phase consisted of re-enacting the error simulation process 3 months after the awareness campaign. The rate and severity of undetected medication errors were measured during the two simulation (first and third) phases. The potential seriousness of the ME was assessed using the NCC MERP(®) index. The rate of undetected medication errors decreased from 12 in the first simulation phase (48%) to five in the second simulation phase (20%, P = 0.04). The number of potential deaths due to administration of a faulty preparation decreased from three to zero. Awareness of iatrogenic risk through error simulation allowed pharmacy technicians to improve their ability to identify errors. This study is the first demonstration of the successful application of a simulation-based learning tool for reducing errors in the preparation of injectable anticancer drugs. Such a program should form part of the continuous quality improvement of risk management strategies for cancer patients. © 2014 John Wiley & Sons Ltd.

  11. Thermal bridges - calculations, thermal bridge values and impact on energy consumption; Kuldebroer - Beregning, kuldebroverdier og innvirkning paa energibruk

    Energy Technology Data Exchange (ETDEWEB)

    Gustavsen, Arild; Thue, Jan Vincent; Blom, Peter; Dalehaug, Arvid; Aurlien, Tormod; Grynning, Steinar; Uvsloekk, Sivert

    2008-07-01

    This report presents the following: Definition of thermal bridge; Possible consequences of thermal bridges; Methods to decide thermal bridge value, inclusive by numerical calculation; Thermal bridge values for different constructions; A proposal for dynamic Thermal bridge atlas. The project report shows thermal bridge values for different constructions such as window insertion, transition between wall/ceiling, wall/floor, corners and ridge. Thermal bridge values for different kind of floor such as concrete, LECA and hollow core. (AG). refs., figs., tabs

  12. Dental therapists' expanded scope of practice in Australia: a 12-month follow-up of an educational bridging program to facilitate the provision of oral health care to patients 26+ years.

    Science.gov (United States)

    Hopcraft, Matthew; Martin-Kerry, Jacqueline M; Calache, Hanny

    2015-01-01

    Prior to 2009, dental therapists' scope of clinical practice in Victoria was limited to patients 25 years or younger. However, increases in dental demand by adults 26+ years required an alternative approach to service delivery. This paper outlines the self-reported confidence and knowledge level of dental therapists at 3, 6, and 12 months postcompletion of an educational program aimed at providing them with the skills to treat adults aged 26+ years. The study also surveyed dentists in the practice about the dental therapists' knowledge and the impact of their extended scope of practice on the clinics' operation. After completion of their educational program, the dental therapists who participated were surveyed at 3, 6, and 12 months postcompletion to assess their self-reported confidence levels and knowledge. Senior dentists at the clinic were surveyed to understand the impact of the subsequent change in practice of the dental therapists who undertook this training, as well as any concerns of perceived educational gaps. Surveys showed increased self-reported confidence levels by the dental therapists at 3, 6, and 12 months after completion of the program. Dental therapists and mentoring dentists identified that further education was needed in areas such as oral medicine, pathology, medically compromised patients, medications, prosthodontics, and referrals. Dental therapists felt confident and knowledgeable postprogram to treat patients 26+ years, within their scope of practice. Dentists generally felt that dental therapists, after completing the educational program, were confident and knowledgeable. Educational areas to focus on in future programs were identified. © 2015 American Association of Public Health Dentistry.

  13. Etiologic factors related to unsatisfactory ThinPrep® cervical cytology: Evaluation and potential solutions to improve

    Directory of Open Access Journals (Sweden)

    Tatyana Kalinicheva

    2015-01-01

    Full Text Available Background: In cervical cytology, the unsatisfactory rates for ThinPrep (TP are slightly higher compared to SurePath. We examined various causes and explored potential for resolution of this discrepancy. Materials and Methods: Totally, 19,422 cases were reviewed and 1000 unsatisfactory specimens were selected and analyzed. 531 specimens were available for wash protocol. Out of 114 unsatisfactory specimens associated with atrophic cellular changes (ACC, 48 were resubmitted by provider and reevaluated. Results: Lubricant and lubricant-like debris/contamination (LUBE was the most common cause of unsatisfactory specimens (68%; 681/1000 followed by blood (7.5%; ACC only (without other interfering factors (2.4%; inflammation (3.0%; and combinations thereof (1.9%. 11.5% showed scant cellularity without an identifiable cause. 3.3% were virtually acellular. Wash protocol improved cellularity in 48% (256/531 of cases. However, only 29% (73/256 of those were satisfactory (with more than 5000 cells. Quantitative reduction in LUBE after wash protocol varied with different morphological subtypes. Interpretation patterns on satisfactory specimens after wash protocol were comparable to the results on selected cohort of specimens during the same study period. Out of 114 ACC, wash protocol was performed on 68 ACC specimens leading to satisfactory TP in 24% (16/68. Totally, 48 cases reported as unsatisfactory with ACC, were resubmitted by the providers between 2 weeks and 2 years. 44 (92% showed increased cellularity, out of which 52% (23/44 did not show ACC. Conclusion: LUBE was the most common cause of unsatisfactory TP in addition to interference by blood and association with atrophic changes. Knowing the morphological spectrum of LUBE would help to identify it as the cause of "unsatisfactory" TP. Communicating the cause of unsatisfactory TP such as LUBE, ACC, and blood would hint the provider to take appropriate precaution during submission of the repeat

  14. Flanking region variation of ForenSeq™ DNA Signature Prep Kit STR and SNP loci in Yavapai Native Americans.

    Science.gov (United States)

    Wendt, Frank R; King, Jonathan L; Novroski, Nicole M M; Churchill, Jennifer D; Ng, Jillian; Oldt, Robert F; McCulloh, Kelly L; Weise, Jessica A; Smith, David Glenn; Kanthaswamy, Sreetharan; Budowle, Bruce

    2017-02-27

    Massively parallel sequencing (MPS) offers advantages over current capillary electrophoresis-based analysis of short tandem repeat (STR) loci for human identification testing. In particular STR repeat motif sequence information can be obtained, thereby increasing the discrimination power of some loci. While sequence variation within the repeat region is observed relatively frequently in some of the commonly used STRs, there is an additional degree of variation found in the flanking regions adjacent to the repeat motif. Repeat motif and flanking region sequence variation have been described for major population groups, however, not for more isolated populations. Flanking region sequence variation in STR and single nucleotide polymorphism (SNP) loci in the Yavapai population was analyzed using the ForenSeq™ DNA Signature Prep Kit and STRait Razor v2s. Seven and 14 autosomal STRs and identity-informative single nucleotide polymorphisms (iiSNPs), respectively, had some degree of flanking region variation. Three and four of these identity-informative loci, respectively, showed ≥5% increase in expected heterozygosity. The combined length- and sequence-based random match probabilities (RMPs) for 27 autosomal STRs were 6.11×10(-26) and 2.79×10(-29), respectively. When combined with 94 iiSNPs (a subset of which became microhaplotypes) the combined RMP was 5.49×10(-63). Analysis of length-based and sequence-based autosomal STRs in STRUCTURE indicated that the Yavapai are most similar to the Hispanic population. While producing minimal increase in X- and Y-STR discrimination potential, access to flanking region data enabled identification of one novel X-STR and three Y-STR alleles relative to previous reports. Five ancestry-informative SNPs (aiSNPs) and two phenotype-informative SNPs (piSNPs) exhibited notable flanking region variation.

  15. Application of ThinPrep Bronchial Brushing Cytology in the Early Diagnosis of Lung Cancer: A Retrospective Study

    Science.gov (United States)

    Liu, Chaoying; Wen, Zhongmei; Li, Yang; Peng, Liping

    2014-01-01

    The majority of lung cancer patients are diagnosed at advanced stages of disease. This study evaluated the diagnostic value of ThinPrep (TP) bronchial brushing cytology in lung cancer. A total of 595 patients with suspicious lung cancer were enrolled in this study. The bronchial brushing samples were prepared by TP. The data were then compared to histology of lung tissue samples. Histologically, 479 of these 595 patients were diagnosed with lung cancer, including 223 cases of lung squamous cell carcinoma (SCC), 77 cases of lung adenocarcinoma (ADC), and 152 cases of small cell lung carcinoma (SCLC). The TP cytology revealed a total of 460 cases of lung cancer (including 232 SCCs, 91 ADCs, and 108 SCLCs). The TP cytological technique had 87.06% sensitivity and 62.93% specificity in the diagnosis of lung cancer. Specifically, TP cytology confirmed 195 of 223 SCCs, 47 of 77 ADCs, and 94 of 152 SCLCs. The TP cytology showed 87.44% sensitivity and 90.05% specificity for the diagnosis of SCC, with a Matthew's correlation coefficient (MCC) of 0.820; while the sensitivity was reduced to 61.04% and the specificity was 90.93% for the diagnosis of ADC, with a MCC of 0.464. For the diagnosis of SCLC, the sensitivity was 61.84% and the specificity was 96.84%, with a MCC of 0.648. Thus, this study demonstrated the usefulness of TP bronchial brushing cytology in the early diagnosis of lung cancer, especially the early stage of lung SCC. A prospective clinical trial will verify these data before being translated into the clinic. PMID:24759600

  16. Mathematical Modelling of Bridges with SAP2000

    OpenAIRE

    Maraž, Miha

    2006-01-01

    The present work describes a relatively new programme module, which is enhanced in the recently released versions of SAP2000 software. The new module, called Bridge Modeler, is intended for simple, parametric mathematical modelling of bridges. The modelling procedure is explained on a test case through the steps of a user-friendly Bridge Wizard. For each step, we described the basic principles and the application possibilities as well as some limitations. We also explained two types of analys...

  17. Bridge Engineering-Oriented Parametric Model

    Institute of Scientific and Technical Information of China (English)

    周凌远; 李乔

    2004-01-01

    A new model is proposed to improve the efficiency of structural modeling. In this model, the bridge structural components are expressed with component description, parametric description and geometric description in a software system. This model provides both convenience and flexibility for users in structural modeling process. The object-oriented method is applied in the model implementation. A bridge analysis preprocessor is developed on the basis of this model. It provides an effective way for bridge modeling.

  18. Industrial steel hall with bridge grane

    OpenAIRE

    Jurejevčič, Nejc

    2016-01-01

    In introduction this diploma thesis describes all main characteristics of (single block)? industrial steel hall with bridge crane. Load arrangement on the supporting structure which covers general actions (snow load and wind action), self-weight and dynamic load of bridge crane was designed with moment resisting frame in transverse direction and frame with concentric diagonal bracing in longitudinual direction. Actions induced by crane bridge was considered in design of runway beam. Steel hal...

  19. Bridge engineering handbook construction and maintenance

    CERN Document Server

    Chen, Wai-Fah

    2014-01-01

    Over 140 experts, 14 countries, and 89 chapters are represented in the second edition of the Bridge Engineering Handbook. This extensive collection highlights bridge engineering specimens from around the world, contains detailed information on bridge engineering, and thoroughly explains the concepts and practical applications surrounding the subject.Published in five books: Fundamentals, Superstructure Design, Substructure Design, Seismic Design, and Construction and Maintenance, this new edition provides numerous worked-out examples that give readers step-by-step design procedures, includes c

  20. Dynamics and Statics of Nonaxisymmetric Liquid Bridges

    Science.gov (United States)

    Alexander, J. Iwan D.; Resnick, Andrew H.; Slobozhanin, L. A.

    1996-01-01

    Theoretical and experimental investigation of the stability of nonaxisymmetric and nonaxisymmetric bridges contained between equal and unequal radii disks as a function of Bond and Weber number with emphasis on the transition from unstable axisymmetric to stable nonaxisymmetric shapes, are conducted. Numerical analysis of the stability of nonaxisymmetric bridges between unequal disks for various orientations of the gravity vector is performed. Experimental and theoretical investigation of large (nonaxisymmetric) oscillations and breaking of liquid bridges are also conducted.

  1. Analysis of liquid bridge between spherical particles

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A pair of central moving spherical particles connected by a pendular liquid bridge with interstitial Newtonian fluid is often encountered in pariculate coalescence process. In this paper, by assuming perfect-wet condition, the effects of liquid volume and separation distance on static liquid bridge are analyzed, and the relation between rupture energy and liquid bridge volume is also studied. These points would be of significance in industrial processes related to adhesive particles.

  2. Nanoclusters a bridge across disciplines

    CERN Document Server

    Jena, Purusottam

    2010-01-01

    This comprehensive book on Nanoclusters comprises sixteen authoritative chapters written by leading researchers in the field. It provides insight into topics that are currently at the cutting edge of cluster science, with the main focus on metal and metal compound systems that are of particular interest in materials science, and also on aspects related to biology and medicine. While there are numerous books on clusters, the focus on clusters as a bridge across disciplines sets this book apart from others. Delivers cutting edge coverage of cluster science Covers a broad range of topics in

  3. Buddha and the bridging relations.

    Science.gov (United States)

    Banerjee, Rahul

    2008-01-01

    The chapter reviews a classical Indian model of consciousness found in the Abhidhamma, a collection of seven treatises in the Pali Canon Tipitaka. The model was based on observations made during advanced vipassana practice, a first-person method taught by the Buddha. The climax of the model consists in the elucidation of 24 'Bridging Relations' causally linking the stream of consciousness, its contents and associated physical events. Review of such a model based on a specialized first-person technique could prove to be a resource of useful ideas providing directions for further research.

  4. Family Medicine: Bridge to Life.

    Science.gov (United States)

    Luz, Clare

    2016-01-01

    Reflecting on the suicide of a close friend, this essay explores what comprises, and inspires a will to live, and how those in Family Medicine can address suicide risk even in the face of debilitating or terminal illness. Research indicates that the will to live is a measurable indicator of general well-being, distinct from depression, and an important predictor of a person's motivation to "hold on to life". As such, understanding what is at the heart of a desire to live should alter clinical practice. This essay offers ideas for ways in which to create bridges for patients that could help sustain life.

  5. A bridge to advanced mathematics

    CERN Document Server

    Sentilles, Dennis

    2011-01-01

    This helpful workbook-style ""bridge"" book introduces students to the foundations of advanced mathematics, spanning the gap between a practically oriented calculus sequence and subsequent courses in algebra and analysis with a more theoretical slant. Part 1 focuses on logic and number systems, providing the most basic tools, examples, and motivation for the manner, method, and concerns of higher mathematics. Part 2 covers sets, relations, functions, infinite sets, and mathematical proofs and reasoning. Author Dennis Sentilles also discusses the history and development of mathematics as well a

  6. Deep bore hole instrumentation along San Francisco Bay Bridges

    Energy Technology Data Exchange (ETDEWEB)

    Bakun, W.; Bowman, J.; Clymer, R.; Foxall, W.; Hipley, P.; Hollfelder, J.; Hutchings, L.; Jarpe, S.; Kasameyer, P.; McEvilly, T.; Mualchin, L.; Palmer, M.

    1998-10-01

    The Bay Bridges down hole network consists of sensors in bore holes that are drilled 100 ft. into bedrock around and in the San Francisco Bay. Between 2 and 8 instruments have been spaced along the Dumbarton, San Mateo, Bay, and San Rafael bridges. The instruments will provide multiple use data that is important to geotechnical, structural engineering, and seismological studies. The holes are between 100 and 1000 ft deep and were drilled by Caltrans. There are twenty- one sensor packages at fifteen sites. Extensive financial support is being contributed by Caltrans, UCB, LBL, LLNL-LDRD, U.C. Campus/Laboratory Collaboration (CLC) program, and USGS. The down hole instrument package contains a three component HS-1 seismometer and three orthogonal Wilcox 73 1 accelerometers, and is capable of recording a micro g from local M = 1.0 earthquakes to 0.5 g strong ground motion form large Bay Area earthquakes.

  7. Review of Energy Harvesters Utilizing Bridge Vibrations

    Directory of Open Access Journals (Sweden)

    Farid Ullah Khan

    2016-01-01

    Full Text Available For health monitoring of bridges, wireless acceleration sensor nodes (WASNs are normally used. In bridge environment, several forms of energy are available for operating WASNs that include wind, solar, acoustic, and vibration energy. However, only bridge vibration has the tendency to be utilized for embedded WASNs application in bridge structures. This paper reports on the recent advancements in the area of vibration energy harvesters (VEHs utilizing bridge oscillations. The bridge vibration is narrowband (1 to 40 Hz with low acceleration levels (0.01 to 3.8 g. For utilization of bridge vibration, electromagnetic based vibration energy harvesters (EM-VEHs and piezoelectric based vibration energy harvesters (PE-VEHs have been developed. The power generation of the reported EM-VEHs is in the range from 0.7 to 1450000 μW. However, the power production by the developed PE-VEHs ranges from 0.6 to 7700 μW. The overall size of most of the bridge VEHs is quite comparable and is in mesoscale. The resonant frequencies of EM-VEHs are on the lower side (0.13 to 27 Hz in comparison to PE-VEHs (1 to 120 Hz. The power densities reported for these bridge VEHs range from 0.01 to 9539.5 μW/cm3 and are quite enough to operate most of the commercial WASNs.

  8. CONDITION RATING SYSTEM FOR THAILAND'S CONCRETE BRIDGES

    Directory of Open Access Journals (Sweden)

    Bonaventure H.W. Hadikusumo

    2010-06-01

    Full Text Available The Bridge Management System is designed to maximise use of available data and determine the optimal strategy to perform necessary improvements to bridges in the most cost-effective manner. This paper provides a condition rating system to meet the requirements of Thailand’s Department of Highways (DOH. A rating system to assess the existing condition of bridges is proposed. Segmental inspection is developed to execute efficient element-level evaluations and collect data that demonstrate deterioration patterns in bridge elements. The paper also describes inspection procedures for field survey execution, which enables observed distresses at the level of sub-elements or members to be allocated. Recommendations from bridge experts reveal that the proposed rating system is robust, implementable in actual practice, and suitable for efficient application in evaluating the nation’s concrete highway bridges. Although the bridge condition rating was developed in response to the specific characteristics of Thailand’s bridges, the proposed methodology can easily be extended to other bridge agencies.

  9. Assessment of the Reliability of Concrete Bridges

    DEFF Research Database (Denmark)

    Middleton, C. R.; Thoft-Christensen, Palle

    a significant shift in emphasis for the highways authorities around the world away from the design of new structures over to maintaining the existing infrastructure. As a result, bridge owners are seeking improved ways of inspecting, assessing, maintaining and repairing their existing stock of bridges...... in the wake of ever increasing traffic loads and volumes, and an ageing population of bridges subject to various mechanisms of deterioration. The goal is to optimise the allocation of limited resources whilst maintaining their bridges in a safe and serviceable condition. Reliability analysis is one tool being...

  10. A data management infrastructure for bridge monitoring

    Science.gov (United States)

    Jeong, Seongwoon; Byun, Jaewook; Kim, Daeyoung; Sohn, Hoon; Bae, In Hwan; Law, Kincho H.

    2015-04-01

    This paper discusses a data management infrastructure framework for bridge monitoring applications. As sensor technologies mature and become economically affordable, their deployment for bridge monitoring will continue to grow. Data management becomes a critical issue not only for storing the sensor data but also for integrating with the bridge model to support other functions, such as management, maintenance and inspection. The focus of this study is on the effective data management of bridge information and sensor data, which is crucial to structural health monitoring and life cycle management of bridge structures. We review the state-of-the-art of bridge information modeling and sensor data management, and propose a data management framework for bridge monitoring based on NoSQL database technologies that have been shown useful in handling high volume, time-series data and to flexibly deal with unstructured data schema. Specifically, Apache Cassandra and Mongo DB are deployed for the prototype implementation of the framework. This paper describes the database design for an XML-based Bridge Information Modeling (BrIM) schema, and the representation of sensor data using Sensor Model Language (SensorML). The proposed prototype data management framework is validated using data collected from the Yeongjong Bridge in Incheon, Korea.

  11. Liquid-based cervical cytology using ThinPrep technology: weighing the pros and cons in a cost-effectiveness analysis.

    Science.gov (United States)

    de Bekker-Grob, Esther W; de Kok, Inge M C M; Bulten, Johan; van Rosmalen, Joost; Vedder, Judith E M; Arbyn, Marc; Klinkhamer, Paul J J M; Siebers, Albertus G; van Ballegooijen, Marjolein

    2012-08-01

    Cervical cancer screening with liquid-based cytology (LBC) has been developed as an alternative to the conventional Papanicolaou (CP) smear. Cost-effectiveness is one of the issues when evaluating LBC. Based on the results of a Dutch randomised controlled trial, we conducted cost-effectiveness threshold analyses to investigate under what circumstances manually screened ThinPrep LBC is cost-effective for screening. The MISCAN-Cervix microsimulation model and data from the Dutch NETHCON trial (including 89,784 women) were used to estimate the costs and (quality-adjusted) life years ((QA)LYs) gained for EU screening schedules, varying cost-effectiveness threshold values. Screening strategies were primary cytological screening with LBC or CP, and triage with human papillomavirus (HPV) testing. Threshold analyses showed that screening with LBC as a primary test can be cost-effective if LBC is less than 3.2 more costly per test than CP, if the sensitivity of LBC is at least 3-5 % points higher than CP, if the quality of life for women in triage follow-up is only 0.39, or if the rate of inadequate CP smears is at least 16.2 %. Regarding test characteristics and costs of LBC and CP, only under certain conditions will a change from CP to manually screened ThinPrep LBC be cost-effective. If none of these conditions are met, implementation of manually screened ThinPrep LBC seems warranted only if there are advantages other than cost-effectiveness. Further research is needed to establish whether other LBC systems will be more favorable with regard to cost-effectiveness.

  12. Effect of glacial acetic acid treatment of cervical ThinPrep specimens on HPV DNA detection with the cobas 4800 HPV test.

    Science.gov (United States)

    McMenamin, M; McKenna, M

    2013-10-01

    Cytology laboratories in the UK routinely treat unsatisfactory cervical liquid-based cytology (LBC) specimens with glacial acetic acid (GAA) to reduce the unsatisfactory rate. However, there is limited published data on the effect of GAA reprocessing on the molecular detection of human papillomavirus (HPV). The aim of this study was to assess the impact of GAA treatment of cervical ThinPrep(®) samples on HPV detection with the cobas(®) 4800 HPV Test (Roche Molecular Systems, Pleasanton, CA, USA). Residual ThinPrep samples (n = 121) were selected to provide a range of typical cytology results and enrich the study samples for HPV positivity. Specimens were equally split into two fractions: one part treated with 10% GAA and the other part left untreated. All samples were HPV tested using the cobas 4800 HPV Test, which simultaneously detects a total of 14 high-risk HPV (hrHPV) genotypes and individually identifies HPV16 and HPV18. The HPV positive/negative status of tested samples determined the level of agreement between treated and untreated fractions; one sample failed owing to detection of a clot by the instrument during pipetting, leaving 120 samples in the study. Statistical analysis was performed using an unweighted kappa. Analysis of overall HPV positivity showed 97.5% (117/120) agreement between the treated and untreated fractions with a kappa value of 0.95. There were 63/65 (96.9%) concordant HPV positive and 54/55 (98.2%) concordant HPV negative results. In addition to the three discordant results for overall HPV positivity, there were three HPV type-specific discrepancies giving a total of 114/120 concordant HPV results (95% agreement). Glacial acetic acid (GAA) treatment of cervical ThinPrep specimens does not have significant adverse affects on HPV detection with the cobas 4800 HPV Test. © 2013 John Wiley & Sons Ltd.

  13. MCSD certification toolkit (exam 70-483) programming in C#

    CERN Document Server

    Covaci, Tiberiu; Varallo, Vincent; O'Brien, Gerry

    2013-01-01

    A perfectly crafted prep guide that prepares you for the MCSD 70-483 The MCSD 70-483 exam is the entry-level Microsoft certification exam for C# developers and this must-have resource offers essential coverage of the exam that will test your competency in C# programming. Each chapter covers one of the core subject domains that comprise the exam. Among the authors are experienced trainers who advised Microsoft on the development of its certification programs, affording them a unique understanding of both the objectives and what it takes to master them. This invaluable knowledge is p

  14. 23 CFR 650.409 - Evaluation of bridge inventory.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Evaluation of bridge inventory. 650.409 Section 650.409... Evaluation of bridge inventory. (a) Sufficiency rating of bridges. Upon receipt and evaluation of the bridge inventory, a sufficiency rating will be assigned to each bridge by the Secretary in accordance with...

  15. 33 CFR 118.85 - Lights on vertical lift bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on vertical lift bridges... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.85 Lights on vertical lift bridges. (a) Lift span lights. The vertical lift span of every vertical lift bridge shall be lighted so that the center of the...

  16. 23 CFR 650.807 - Bridges requiring a USCG permit.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Bridges requiring a USCG permit. 650.807 Section 650.807... BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.807 Bridges requiring a USCG... improvement or construction of a bridge over navigable waters except for the exemption exercised by FHWA...

  17. 33 CFR 118.65 - Lights on fixed bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on fixed bridges. 118.65 Section 118.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a...

  18. 33 CFR 118.70 - Lights on swing bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on swing bridges. 118.70 Section 118.70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges....

  19. Finite element of multilayer surfacing systems on orthotropic steel bridges

    NARCIS (Netherlands)

    Li, J.; Liu, X.; Scarpas, A.; Tzimiris, G.

    2013-01-01

    Light weight orthotropic steel bridge decks have been widely utilized for bridges in seismic zones, movable bridges and long span bridges. In the last three decades, severe problems were reported in relation to asphaltic surfacing materials on orthotropic steel deck bridges. Earlier investigations h

  20. Zero transmission of HIV– “Still a long way to go” An Update on TasP : PrEP and PEP of HIV infection

    OpenAIRE

    Hiremath, Ravishekar N; Kamble, Manjunath; Bhalla, Sandeep; Ghodke, Sandhya; R K Chaudhary

    2014-01-01

    AIDS emerged as one of the most important public health issues of the late twentieth and early twenty-first centuries and is now one of the leading causes of global morbidity and mortality. The AIDS epidemic has prompted wide-reaching changes in public health, clinical practice, and scientific research, and has had a great impact upon societies throughout the world. This review article gives an in site into updates on TasP (Treatment as prevention), PrEP (pre-exposure prophylaxis) and PEP (Po...

  1. Lactacidemia en el umbral anaeróbico. Estudio en varones prepúberes de escuelas deportivas de fútbol.

    OpenAIRE

    2004-01-01

    RESUMEN El objetivo principal es conocer la conducta del lactato en sangre. Situación bibliográfica. Estructurada en cinco apartados: reservas energéticas y límites metabólicos, la regulación ácido-base, el metabolismo del lactato, el umbral anaeróbico y las diferencias existentes entre niños y adultos. Nos centramos en los menores niveles de lacticemia en los niños, el mayor umbral anaeróbico en prepúberes frente a adultos y las diferencias de adaptación del metabolismo glucolítico....

  2. Investigations concerning seismic response control of self-anchored suspension bridge with MR dampers

    Institute of Scientific and Technical Information of China (English)

    Menggang YANG; Zhengqing CHEN; Jianhua HU

    2008-01-01

    To mitigate the seismic response of selfanchored suspension bridges, equations of motion governing the coupled system of bridge- magneto-rheological (MR) dampers subject to seismic excitation are formulated by employing the phenomenological model of MR dampers. A corresponding computer program is developed and employed for studying the seismic response control of a self-anchored suspension bridge with a main span of 350 m. The effect of variable current and number of dampers on seismic response control is investigated. The numerical results indicate the longitudinal displacement of the tower top and bridge girder decrease with the increase in input current and number of MR dampers attached longitudinally at the tower-girder connections, and the internal forces of the tower are effectively attenuated as well. It appears that small electronic current (0.5 A in this study) may sufficiently attenuate the seismic responses for practical engineering applications.

  3. Light-weight aluminium bridges and bridge decks. An overview of recent applications

    NARCIS (Netherlands)

    Maljaars, J.; Soetens, F.; Kluyver, D. de

    2008-01-01

    The last decades have shown a large increase in the application of aluminium alloys for light-weight bridges. For bridge construction, aluminium alloys have some specific advantages, but also some points of attention. This paper deals with some recent projects of aluminium bridges, and for these pro

  4. Light-weight aluminium bridges and bridge decks. An overview of recent applications

    NARCIS (Netherlands)

    Maljaars, J.; Soetens, F.; Kluyver, D. de

    2008-01-01

    The last decades have shown a large increase in the application of aluminium alloys for light-weight bridges. For bridge construction, aluminium alloys have some specific advantages, but also some points of attention. This paper deals with some recent projects of aluminium bridges, and for these

  5. Bridge Workshop : Enhancing Bridge Performance, February 21-22, 2008, Reston, Virginia : workshop report

    Science.gov (United States)

    Sreenivas Alampalli; Sheila Rimal Duwadi; Reagan Sentelle Herman; Danielle D. Kleinhans; Khaled Mahmoud; James C. Ray; James P. Wacker; Nur Yazdani

    2008-01-01

    The participants to the workshop were given the charge to discuss (1) bridge design issues including best practices in design and detailing that could be used to improve durability, extend service life and prevent premature deterioration, (2) performance measures needed to better determine bridge condition, (3) technologies that could be used to monitor bridge life and...

  6. Bridging history and social psychology

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre; Yamamoto, Koji

    2012-01-01

    This special issue aims to bridge history and social psychology by bringing together historians and social psychologists in an exercise of reading and learning from each other’s work. This interdisciplinary exercise is not only timely but of great importance for both disciplines. Social psycholog......This special issue aims to bridge history and social psychology by bringing together historians and social psychologists in an exercise of reading and learning from each other’s work. This interdisciplinary exercise is not only timely but of great importance for both disciplines. Social...... psychologists can benefit from engaging with historical sources by being able to contextualise their findings and enrich their theoretical models. It is not only that all social and psychological phenomena have a history but this history is very much part of present-day and future developments. On the other...... hand historians can enhance their analysis of historical sources by drawing upon the conceptual tools developed in social psychology. They can “test” these tools and contribute to their validation and enrichment from completely different perspectives. Most important, as contributions to this special...

  7. Global monitoring concept for bridges

    Science.gov (United States)

    Bergmeister, Konrad; Santa, Ulrich

    2000-06-01

    Knowledge of the integrity of in-service structures on a continuous time basis is an ultimate objective for owners and maintenance authorities. The development of a life extension and/or replacement strategy for highway structures is a crucial point in an effective bridge management system. A key component of such a bridge management system is a means of surveillance techniques and determining the condition of an existing structure within the normative and budgetary constraints. Recent advances in sensing technologies and material/structure damage characterization combined with current developments in computations and communications have resulted in a significant interest in developing diagnostic technologies for monitoring the integrity of and for the detection of damages of structures. To identify anomalies and deterioration processes, it is essential to understand the relationships between the signal measurements and the real occurred phenomena. Therefore, the comparison of measured and calculated data in order to tune and validate the mechanical and numerical model assumptions is an integral part of any system analysis. Finally, the interpreted results of all measurements should be the basis for the condition assessment and the safety evaluation of a structure to facilitate replacement and repair decisions.

  8. The Bridge of Mandolin County

    Science.gov (United States)

    Lantz, Juliette M.; Feindt, Jenny E.; Lewellyn, Eric P. B.; Walczak, Mary M.

    1999-12-01

    The Bridge of Mandolin County is a case designed to teach the general chemistry principles of molar mass, ions and aqueous reactions, solubility rules, and inorganic nomenclature. Through the instructor-facilitated class discussion, students consider the options before the Mandolin Town Council regarding deicing the newly constructed bridge connecting Mandolin with a large nearby city. The students must decipher contradictory claims made on behalf of sodium chloride, the traditional deicer, and calcium magnesium acetate, a new environmentally friendly deicer, to arrive at the most cost-effective and environmentally appropriate deicing product. As they work through the analysis they raise questions that can be addressed in a laboratory setting. Four optional role-playing experiments are included, which can be used by the students to gather information helpful to resolution of the case. The case is intended to be used over two class periods, with a laboratory period in between, though suggestions for other models are provided. Laboratory procedures include an EDTA titration for Ca2+ and Mg2+, a gravimetric analysis, a qualitative examination of ions and solubility, an introduction to freezing point depression and measurement, and an experimental design activity. This case can also successfully be used without alteration in non-majors chemistry or environmental chemistry courses, or upper-level analytical or environmental chemistry courses.

  9. Full Model Wind Tunnel Study on the Xia-Zhang Bridge Under Operation Stage

    Directory of Open Access Journals (Sweden)

    Ayad T. Saeed

    2010-01-01

    Full Text Available Problem statement: Long-span cable-stayed bridges under service and particular construction conditions are very susceptible to wind action due to their great flexibility, so the aerodynamic stability is becoming a major concern in the design and construction phrases. Cable-stayed bridges may exhibit wind-induced vibration phenomena such as flutter, buffeting and vortex oscillation under wind excitation. The study concentrated on the issues concerning the aerodynamic response of Xia-Zhang cable-stayed Bridge to make it safe and stable under wind action. Although there have been accumulating experience in the building of cable-stayed bridges and research on wind-resistant stability in Chinese Mainland, most of the research focuses on inland cable-stayed bridges or littoral ones of mid-length, but not on littoral ones whose main span is over 600 m. Therefore, wind-resistant performance research of north branch bridge of Xia-Zhang cross-sea Bridges is very necessary and important for its wind-resistant stability, safety and applicability in the operation condition. Approach: This study mainly presented the wind tunnel test program of the Xia-Zhang Bridge aeroelastic full model, including test method, test contents, test results and so on. Results: The test results contained Root Mean Square (RMS of accelerations and displacements as well as average values of displacements. Conclusion: The conclusions were as follows: (a In the uniform flow field, under the condition of entire bridge without rail may vibration divergence occur when α = 3°, V>122 m sec-1. (b No vortex-induced vibration with extreme amplitudes or static collapsing was detected in all the testing conditions. (c In the turbulent flow field, there were very obvious buffeting phenomena. Responses to turbulence are quite intense.

  10. Salt-bridge energetics in halophilic proteins.

    Directory of Open Access Journals (Sweden)

    Arnab Nayek

    Full Text Available Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are -3.0 kcal mol-1. Majority (78% of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46% with a net contribution of -5.0 kcal mol-1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (-10 kcal mol-1 exceeds than that of bridge term (-7 kcal mol-1. Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic

  11. A Statistical Observation of Crowns and Bridges in 1988 Part 2 : Bridge

    OpenAIRE

    小林, 賢一; 小坂, 茂; 柳田, 史城; 稲生, 衡樹; 大島, 俊明; 高橋, 喜博; 岩井, 啓三; 甘利, 光治; 中根, 卓

    1991-01-01

    A study was made of 207 bridges which had been fabricated for patients at the Prosthodontic Clinic of Matsumoto Dental College during 1988. Some of results were as follows; 1) 47.3% of the patients were males and 52.7% were females. 2) 92.8% of the patients were between 20 and 69 years old. 3) 65.2%of the bridges were fabricated as 3-unit bridges. 4) 77.8% were fabricated as 1-pontic bridges. 5) There were fewer bridge retainers for the lower anterior segment than for other segments. 6) 52.3%...

  12. Lifetime Reliability Assessment of Concrete Slab Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    A procedure for lifetime assesment of the reliability of short concrete slab bridges is presented in the paper. Corrosion of the reinforcement is the deterioration mechanism used for estimating the reliability profiles for such bridges. The importance of using sensitivity measures is stressed. Fi...

  13. Re-Assessment of Concrete Bridges

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    In this paper two aspects of re-assessment of the reliability of concrete bridges are discussed namely modelling of the corrosion of reinforcement and updating of uncertain variables. The main reason for deterioration of concrete bridges is corrosion of the reinforcement. Therefore, modelling...

  14. The I-35W bridge Project Website

    DEFF Research Database (Denmark)

    Kampf, Constance

    How can websites be used to rebuild trust?  In August 2007, the Interstate Highway 35-W bridge in Minneapolis, MN collapsed during rush hour.  Although many people were rescued and casualties were as limited as could be expected due to quick and effective intervention, the image of a major bridge...

  15. Active aerodynamic stabilisation of long suspension bridges

    DEFF Research Database (Denmark)

    Nissen, Henrik Ditlev; Sørensen, Paul Haase; Jannerup, Ole Erik

    2004-01-01

    The paper describes the addition of actively controlled appendages (flaps) attached along the length of the bridge deck to dampen wind-induced oscillations in long suppension bridges. A novel approach using control systems methods for the analysis of dynamic stability is presented. In order to ma...

  16. Methods and tools for diagnosing bridge structures

    Directory of Open Access Journals (Sweden)

    С.Ф. Філоненко

    2008-03-01

    Full Text Available  In the paper is reviewed the methods and means, which used at technical diagnostic of bridge designs. The general approaches to technical diagnostic, the main methods, primary converters and hardwares, which used on static and dynamic tests of bridge designs are reviewed.

  17. General framework for bridge life cycle design

    Institute of Scientific and Technical Information of China (English)

    Junhai MA; Airong CHEN; Jun HE

    2009-01-01

    Based on a detailed illustration for bridge life cycle design which comprises the processes of service life design, aesthetics design, performance design, environ-mental and ecological design, inspection, maintenance and repair design as well as cost analysis, this paper presented a general framework for bridge life cycle design comprising three design phases and six design processes.

  18. COUPLING VIBRATION OF VEHICLE-BRIDGE SYSTEM

    Institute of Scientific and Technical Information of China (English)

    陈炎; 黄小清; 马友发

    2004-01-01

    By applying the sinusoidal wave mode to simulate the rugged surface of bridge deck,accounting for vehicle-bridge interaction and using Euler-Bernoulli beam theory, a coupling vibration model of vehicle-bridge system was developed. The model was solved by mode analyzing method and Runge-Kutta method, and the dynamic response and the resonance curve of the bridge were obtained. It is found that there are two resonance regions, one represents the main resonance while the other the minor resonance, in the resonance curve. The influence due to the rugged surface, the vibration mode of bridge, and the interaction between vehicle and bridge on vibration of the system were discussed. Numerical results show that the influence due to these parameters is so significant that the effect of roughness of the bridge deck and the mode shape of the bridge can't be ignored and the vehicle velocity should be kept away from the critical speed of the vehicle.

  19. Bridges and the City: An Interdisciplinary Project.

    Science.gov (United States)

    Singer, Judith Y.; Goodman, Cecelia; Ridley, Theodora; Singer, Alan

    2000-01-01

    Describes an interdisciplinary project to help elementary school children discover the relationship among technology, history, and geography that involved the building of a model Brooklyn Bridge and considering the history and role of the real bridge. Suggestions for similar projects for other cities are appended. (JPB)

  20. Heavy Vehicles on Minor Highway Bridges

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Nielsen, Søren R. K.; Enevoldsen, I.

    the results obtained using the numerical models given in details in "Heavy Vehicles on Minor Highway Bridges : dynamic modelling of vehicles and bridges". The models are established using a ordinary vehicle which consists of a 48 t Scania with a 3 axle tractor and a 3 axle trailer, joined in a flexible hinge...

  1. Planar Hall effect bridge magnetic field sensors

    DEFF Research Database (Denmark)

    Henriksen, A.D.; Dalslet, Bjarke Thomas; Skieller, D.H.

    2010-01-01

    Until now, the planar Hall effect has been studied in samples with cross-shaped Hall geometry. We demonstrate theoretically and experimentally that the planar Hall effect can be observed for an exchange-biased ferromagnetic material in a Wheatstone bridge topology and that the sensor signal can...... Hall effect bridge sensors....

  2. Active aerodynamic stabilisation of long suspension bridges

    DEFF Research Database (Denmark)

    Nissen, Henrik Ditlev; Sørensen, Paul Haase; Jannerup, Ole Erik

    2004-01-01

    The paper describes the addition of actively controlled appendages (flaps) attached along the length of the bridge deck to dampen wind-induced oscillations in long suppension bridges. A novel approach using control systems methods for the analysis of dynamic stability is presented. In order to ma...

  3. History of cable-stayed bridges

    DEFF Research Database (Denmark)

    Gimsing, Niels Jørgen

    1999-01-01

    The principle of supporting a bridge deck by inclined tension members leading to towers on either side of the span has been known for centuries. However, the real development of cable-stayed bridges did not begin before the 1950s. Since then the free span has been increased from 183 m in the Strö...

  4. Disturbance indicator benchmark for urban bridge construction

    NARCIS (Netherlands)

    Brouwer, J.; Vogel, R.; Thodesen, C.

    2013-01-01

    European bridges are today in a state of particular concern with over 50% of European urban bridges being more than 40 years old and thus requiring considerable maintenance or possibly even replacement [1]. This means that interventions in the present infrastructure have to be made while ensuring

  5. Passing the Einstein-Rosen bridge

    CERN Document Server

    Katanaev, M O

    2013-01-01

    We relax the requirement of geodesic completeness of a space-time. Instead, we require test particles trajectories to be smooth only in the physical sector. Test particles trajectories for Einstein--Rosen bridge are proved to be smooth in the physical sector, and particles can freely penetrate the bridge in both directions.

  6. Precast Pearl-Chain concrete arch bridges

    DEFF Research Database (Denmark)

    Halding, Philip Skov; Hertz, Kristian Dahl; Schmidt, Jacob Wittrup

    2015-01-01

    A Pearl-Chain Bridge is a closed-spandrel arch bridge consisting of a number of straight pre-fabricated so called Super-Light Deck elements put together in an arch shape by post-tensioning cables. Several Pearl-Chain arches can be positioned adjacent to each other by a crane to achieve a bridge...... the technology was used. We also study other important components and details in the Pearl-Chain Bridge concept and review the effects of different types of loads. A theoretical case study of a circular 30 m span Pearl-Chain Bridge is presented showing the influence of a number of parameters: The number of post-tensioning......, and gives a large positive bending moment below the load and a smaller negative bending moment in the unloaded side. When the Pearl-Chain Bridge concept is compared to other pre-fabricated arch bridge solutions we find a number of advantages when using Pearl-Chain Bridges: Straight elements, combination...

  7. Seismic response of steel suspension bridge

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, D.B. [Lawrence Livermore National Lab., CA (United States); Astaneh-Asl, A. [California Univ., Berkeley, CA (United States). Dept. of Civil and Environmental Engineering

    1996-11-01

    Performing accurate, realistic numerical simulations of the seismic response of long-span bridges presents a significant challenge to the fields of earthquake engineering and seismology. Suspension bridges in particular represent some of the largest and most important man-made structures and ensuring the seismic integrity of these mega-structures is contingent on accurate estimations of earthquake ground motions and accurate computational simulations of the structure/foundation system response. A cooperative, multi-year research project between the Univ. of California and LLNL was recently initiated to study engineering and seismological issues essential for simulating the response of major structures. Part of this research project is focused on the response of the long-span bridges with the San Francisco-Oakland Bay Bridge serving as a case study. This paper reports on the status of this multi-disciplinary research project with emphasis on the numerical simulation of the transient seismic response of the Bay Bridge.

  8. The I-35W bridge Project Website

    DEFF Research Database (Denmark)

    Kampf, Constance

    How can websites be used to rebuild trust?  In August 2007, the Interstate Highway 35-W bridge in Minneapolis, MN collapsed during rush hour.  Although many people were rescued and casualties were as limited as could be expected due to quick and effective intervention, the image of a major bridge...... collapsing during rush hour damaged the Minnesota Department of Transportation's reputation and resulted in the loss of public trust for the organization.  The ensuing bridge reconstruction project included a project website intended to rebuild this trust through transparency, community involvement......, and the use of multimodal features.  This paper looks at the I35-W bridge reconstruction project in Minneapolis through web-based communication by the Minnesota Department of Transportation (MnDOT) about the project. The MnDOT bridge reconstruction website will be examined using a combination of 1). Weick...

  9. The receptor RAGE: Bridging inflammation and cancer

    Directory of Open Access Journals (Sweden)

    Hess Jochen

    2009-05-01

    Full Text Available Abstract The receptor for advanced glycation end products (RAGE is a single transmembrane receptor of the immunoglobulin superfamily that is mainly expressed on immune cells, neurons, activated endothelial and vascular smooth muscle cells, bone forming cells, and a variety of cancer cells. RAGE is a multifunctional receptor that binds a broad repertoire of ligands and mediates responses to cell damage and stress conditions. It activates programs responsible for acute and chronic inflammation, and is implicated in a number of pathological diseases, including diabetic complications, stroke, atheriosclerosis, arthritis, and neurodegenerative disorders. The availability of Rage knockout mice has not only advanced our knowledge on signalling pathways within these pathophysiological conditions, but also on the functional importance of the receptor in processes of cancer. Here, we will summarize molecular mechanisms through which RAGE signalling contributes to the establishment of a pro-tumourigenic microenvironment. Moreover, we will review recent findings that provide genetic evidence for an important role of RAGE in bridging inflammation and cancer.

  10. Technology transfer — bridging space and society

    Science.gov (United States)

    Students of Technology Transfer Design Project Team (ISU Summer Session 1997)

    Strategies, policies and methods by which technologies can be cross-fertilized between the space and non-space sectors were examined by students of the design project "Technology Transfer — Bridging Space and Society". This project was undertaken by students attending the 1997 10th Anniversary Summer Session Program of the International Space University. General issues relating to transfer of technology were discussed including definitions and mechanisms (push, pull, interactive and pro-active). As well as looking at case studies and the impact of national policies on space agencies, the design project also sought to look at technology transfer on a country-by-country basis, selecting various countries for scrutiny and reporting on their technology transfer status. The project report shows how transfer of technology varies between nations and when analyzed with the case studies identifies the general strategies, policies and methods in use and how they can be improved. Finally, the report seeks to recommend certain issues to governments, space agencies and industrial organizations to facilitate the transfer of technology. These include the development of a generic metrics system and the implementation of better appropriate procedures and mechanisms for a positive diffusion process between space and non-space sectors.

  11. Elementary number theory with programming

    CERN Document Server

    Lewinter, Marty

    2015-01-01

    A successful presentation of the fundamental concepts of number theory and computer programming Bridging an existing gap between mathematics and programming, Elementary Number Theory with Programming provides a unique introduction to elementary number theory with fundamental coverage of computer programming. Written by highly-qualified experts in the fields of computer science and mathematics, the book features accessible coverage for readers with various levels of experience and explores number theory in the context of programming without relying on advanced prerequisite knowledge and con

  12. Improving Laboratory Efficiency by Automation of Preanalytic Processing of ThinPrep Specimens for Real-Time PCR High-Risk HPV Testing.

    Science.gov (United States)

    Barbieri, Daniela; Venturoli, Simona; Costa, Silvano; Landini, Maria Paola

    2016-06-01

    Cervical specimens collected in liquid-based cytology (LBC) media are the most common sample type used for high-risk human papillomavirus (HPV) testing. Since preanalytic steps such as vortexing and decapping vials, liquid transfer to a sample input tube with matching unique identifier, and recapping the original vials are required for processing LBC samples prior to running the Abbott RealTime High Risk HPV assay (Abbott, Wiesbaden, Germany), a full manual execution can be complicated, especially in high-throughput diagnostic contexts. Here, a custom-configured worktable setup for the Tecan Freedom EVO (Tecan, Männedorf, Switzerland) designed to automate and control preanalytic steps for ThinPrep (Hologic, Marlborough, MA) samples was used to evaluate the impact of automated versus manual preanalytics. Archival results for manual processing of 226 samples were compared with those obtained with the Tecan protocol, observing a very good overall concordance for final assay interpretation (95.6%). High overall agreement (100%) resulted also from retesting 99 samples by both the preanalytical protocols. High reproducibility was observed analyzing 23 randomly selected samples by automated preprocessing in triplicate. Hence, the new configuration of the Tecan platform translates the manual steps required to process ThinPrep specimens into automated operations, controls sample identification, and allows for saving hands-on time, while maintaining assay reproducibility and ensuring reliability of results, making it suitable for screening settings.

  13. Evaluation of the Illumina ForenSeq™ DNA Signature Prep Kit - MPS forensic application for the MiSeq FGx™ benchtop sequencer.

    Science.gov (United States)

    Xavier, Catarina; Parson, Walther

    2017-05-01

    Massively Parallel (Next Generation) Sequencing (MPS) technologies have recently been proven useful and successful in typing various markers relevant in forensic genetics, such as STRs, SNPs and mitochondrial genomes. Early studies investigated self-developed DNA libraries, commercially supplied kits are currently being made available to allow a smoother and gradual implementation of such technologies in forensic laboratories. The ForenSeq™ DNA Signature Prep Kit (Illumina, CA) is the first commercially available STR kit that can be used on the MiSeq FGx™ (Illumina, CA) benchtop high-throughput sequencer. This kit allows the simultaneous typing of 59 STRs and up to 172 SNPs in a single reaction and presents a short library preparation protocol adapted to contemporary forensic requirements. In this study, we evaluated the beta version of the ForenSeq DNA Signature Prep Kit MiSeq FGx system by investigating reproducibility, sensitivity, mixtures, concordance, casework-type and aDNA samples and found it to perform successfully, proving to be a robust method for future forensic applications. MPS brings the possibility of complex multiplexing, high sensitivity and sequencing resolution to forensics; however, the need for consensual directions on databasing, data storage and nomenclature must be taken into consideration. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Jumping from the Brooklyn Bridge.

    Science.gov (United States)

    Kurtz, R J; Pizzi, W F; Richman, H; Tiefenbrun, J

    1987-07-01

    In an attempt to identify factors contributing to survival of free fall and impact, we evaluated the records of four patients who survived a jump from the Brooklyn Bridge into the East River in New York Harbor between 1977 and 1985. All four patients were male and ranged in age from 22 to 67 years. They had free falls of between 41.0 and 48.8 meters. All of the patients were brought to the hospital within 24 minutes of entering the water. Three of the four had emergency surgical treatment and the fourth patient had only minor injuries. All four patients survived the suicide attempts. The length of the hospital stay ranged from two to 26 days.

  15. Building bridges … and accelerators

    CERN Multimedia

    2009-01-01

    Lyn Evans, the LHC project leader, was awarded an honorary doctorate from the University of Geneva (UNIGE) to celebrate his role not just in building accelerators, but also in building bridges between nations. He was one of four notables honoured at the event on Friday 5 June, coinciding with the University’s 450th Anniversary. Lyn Evans arriving at the ceremony with Archbishop Desmond Tutu. "It was a big surprise when I found out I’d been nominated," recounts Evans, "but it was an even bigger surprise to find out with whom I’d been nominated". At the ceremony Evans was awarded the honorary doctorate along with three others: Archbishop Desmond Tutu, who was acclaimed for his fight against apartheid in South Africa, Mary Robinson, first woman president of Ireland and former United Nations’ high commissioner of human rights, and Pascal Lamy, Director-General of the World Trade Organization. The award ceremony, known as the �...

  16. Xanthene-bridged cofacial bisporphyrins.

    Science.gov (United States)

    Chang, C J; Deng, Y; Heyduk, A F; Chang, C K; Nocera, D G

    2000-03-06

    The synthesis and characterization of cofacial bisporphyrins juxtaposed by xanthene-bridged pillars are presented. The one-pot preparation of the xanthene dialdehyde avoids the lengthy bridge synthesis accompanying other cofacial porphyrin systems, thus allowing for the facile preparation of homobimetallic zinc (10), copper (11), and nickel (12) complexes. The cofacial orientation of the two porphyrin macrocycles was confirmed by X-ray crystallography. Structural data are provided for bisporphyrins 10-12: 10 (C79H82N8OZn2), triclinic, space group P1, a = 11.2671(2) A, b = 14.9809(2) A, c = 20.4852(2) A, alpha = 101.6680(10) degrees, beta = 100.8890(10) degrees, gamma = 101.8060(10) degrees, Z = 2; 11 (C79H82N8OCu2), triclinic, space group P1, a = 11.21410(10) A, b = 14.9539(5) A, c = 20.6915(7) A, alpha = 101.810(2) degrees, beta = 101.044(2) degrees, gamma = 101.722(2) degrees, Z = 2; 12 (C79H82N8ONi2), monoclinic, space group C2/c, a = 24.1671(4) A, b = 10.669 A, c = 50.5080(9) A, beta = 99.553(2) degrees, Z = 8. Exciton interactions between the porphyrin rings are apparent in electronic spectra, consistent with the cofacial superstructure. The combination of structural and spectroscopic data provides a basis for the design of additional metal derivatives for the activation of dioxygen and other small molecules.

  17. Concrete bridge deck early problem detection and mitigation using robotics

    Science.gov (United States)

    Gucunski, Nenad; Yi, Jingang; Basily, Basily; Duong, Trung; Kim, Jinyoung; Balaguru, Perumalsamy; Parvardeh, Hooman; Maher, Ali; Najm, Husam

    2015-04-01

    More economical management of bridges can be achieved through early problem detection and mitigation. The paper describes development and implementation of two fully automated (robotic) systems for nondestructive evaluation (NDE) and minimally invasive rehabilitation of concrete bridge decks. The NDE system named RABIT was developed with the support from Federal Highway Administration (FHWA). It implements multiple NDE technologies, namely: electrical resistivity (ER), impact echo (IE), ground-penetrating radar (GPR), and ultrasonic surface waves (USW). In addition, the system utilizes advanced vision to substitute traditional visual inspection. The RABIT system collects data at significantly higher speeds than it is done using traditional NDE equipment. The associated platform for the enhanced interpretation of condition assessment in concrete bridge decks utilizes data integration, fusion, and deterioration and defect visualization. The interpretation and visualization platform specifically addresses data integration and fusion from the four NDE technologies. The data visualization platform facilitates an intuitive presentation of the main deterioration due to: corrosion, delamination, and concrete degradation, by integrating NDE survey results and high resolution deck surface imaging. The rehabilitation robotic system was developed with the support from National Institute of Standards and Technology-Technology Innovation Program (NIST-TIP). The system utilizes advanced robotics and novel materials to repair problems in concrete decks, primarily early stage delamination and internal cracking, using a minimally invasive approach. Since both systems use global positioning systems for navigation, some of the current efforts concentrate on their coordination for the most effective joint evaluation and rehabilitation.

  18. Implementation of Bridge Management System on Interurban Bridge in Maluku Province

    Directory of Open Access Journals (Sweden)

    Erwin Marasabessy

    2015-05-01

    Full Text Available Bridges as transport infrastructures play a vital role in smoothing traffic flows. The success of a bridge in playing its role and serving its function depends on its management. The Directorate General of Highways of the Ministry of Public Work has used a system to manage bridges known as the Bridge Management System (BMS. The system allows a systematic plan and provides a uniform procedure for all bridge operation activities on the national and provincial level. Data from Implementation Agency of National Inter-Urban Roads of Area IX, Northern Maluku in 2011 indicates that the total length of national roads in Maluku Province is 15,238.01 M, with a total of 562 bridges. In Ambon Island, especially, there are 52 bridges totaling 1,176.25 m in length. The study was conducted at several inter-urban bridges in Maluku Province of Ambon Island: Wai Batu Merah, Wai Ruhu, Wai Lawa, Wai Yari and Wai Tua bridges. Assessment of bridge structure conditions was conducted visually to determine the conditions of the existing bridges comprehensively by referring to the Bridge Management System (BMS complemented with a computer-based Bridge Management Information System (BMIS. Condition scores for the five bridges—Wai Batu Merah, Wai Ruhu, Wai Lawa, Wai Yari, and Wai Tua, according to Bridge Management System, are 2, 1, 2, 1, and 2 respectively. The scores of the five bridges indicate that their physical condition can be categorized as good or with minor defects. Based on technical screening, the proposed treatment for Wai Batu Merah, Wai Ruhu, Wai Lawa, dan Wai Tua bridges is the rehabilitation of their sub-elements. As for the Wai Yari Bridge, the treatment will be maintained regularly. The defect repair costs are IDR 149,138,238.00, IDR 81,048,000.00, IDR 174,579,106.10, IDR 79,233,324.01 and IDR 238,323,258.60 for Wai Batu, Wai Ruhu, Wai Lawa, Wai Yari, and Wai Tua Bridges, respectively.

  19. Formulation of Equations of Motion for a Simply Supported Bridge under a Moving Railway Freight Vehicle

    Directory of Open Access Journals (Sweden)

    Ping Lou

    2007-01-01

    Full Text Available Based on energy approach, the equations of motion in matrix form for the railway freight vehicle-bridge interaction system are derived, in which the dynamic contact forces between vehicle and bridge are considered as internal forces. The freight vehicle is modelled as a multi-rigid-body system, which comprises one car body, two bogie frames and four wheelsets. The bogie frame is linked with the car body through spring-dashpot suspension systems, and the bogie frame is rigidly linked with wheelsets. The bridge deck, together with railway track resting on bridge, is modelled as a simply supported Bernoulli-Euler beam and its deflection is described by superimposing modes. The direct time integration method is applied to obtain the dynamic response of the vehicle-bridge interaction system at each time step. A computer program has been developed for analyzing this system. The correctness of the proposed procedure is confirmed by one numerical example. The effect of different beam mode numbers and various surface irregularities of beam on the dynamic responses of the vehicle-bridge interaction system are investigated.

  20. Dynamic Response of the Suspension Spans of the San Francisco-Oakland Bay Bridge

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, D; Astaneh-Asl, A; Larsen, S; Hutchings, L

    2005-11-03

    The dynamic response of the suspension spans of the San Francisco-Oakland Bay Bridge (SFOBB) have been numerically modeled in a case-study to investigate the effects of long-period, near-field ground motions on flexible suspension bridges. The structural simulation model used in the study was developed as a special purpose computer program tailored to efficiently simulate the nonlinear response of cable supported bridges. The simulation model includes a number of special element technologies and solution algorithms that enable efficient nonlinear analysis of suspension bridges. The ground motions used in the study were site specific synthetic records for a Mw=7.25 earthquake along the Hayward fault at 12-15 km distant, and actual measured near-field records from the Izmit Turkey (1999) and Chi-Chi Taiwan (1999) earthquakes. These records include near- and far-field broad-band motions for three components. The results of the numerical simulations indicate that low frequency waveforms associated with near-field motions can place a significant demand on the structural systems of suspension bridges, and must be accounted for in suspension bridge analysis and design.