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Sample records for prenatal ultrasound showed

  1. Prenatal ultrasound - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100197.htm Prenatal ultrasound - series—Procedure, part 1 To use the sharing ... Editorial team. Related MedlinePlus Health Topics Prenatal Testing Ultrasound A.D.A.M., Inc. is accredited by ...

  2. Teaching prenatal ultrasound to family medicine residents.

    Science.gov (United States)

    Dresang, Lee T; Rodney, William MacMillan; Dees, Jason

    2004-02-01

    Prenatal ultrasound is a powerful diagnostic tool, but there has been little research on how to teach ultrasound to family physicians. The available evidence supports teaching through didactics followed by supervised scanning. Didactic topics include physics and machine usage, indications, fetal biometry, anatomic survey, practice management, ethical issues, and resources. Supervised scanning reinforces the didactic components of training. A "hand-on-hand" supervised scanning technique is recommended for the transmission of psychomotor skills in these sessions. Curricula for teaching ultrasound should include information on which residents will be taught prenatal ultrasound, who will teach them, how to create time for learning ultrasound skills, and how to test for competency. The literature suggests that competency can be achieved within 25-50 supervised scans. Measures of competency include examination and qualitative analysis of scanning. Competency-based testing needs further development because no uniform standards have been established.

  3. Ultrasound prenatal diagnosis of congenital primary aphakia: case report

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    Di Meglio, Filippo; Vascone, Carmine; Di Meglio, Letizia; Turco, Luigi Carlo Lo; Vitale, Salvatore Giovanni; Cignini, Pietro; Valenti, Gaetano; Gulino, Ferdinando Antonio; Rapisarda, Agnese Maria Chiara; Cianci, Stefano

    2015-01-01

    Introduction the ultrasound prenatal diagnosis of aphakia is a difficult diagnosis and often requires a genetic study of the karyotype. Case report we present a rare case of prenatal bilateral aphakia, confirmed after bird. The patient was observed by ultrasound during the 23rd week of pregnancy. Through transabdominal ultrasound the lens could not be visualized bilaterally. The remaining anathomy, explorable by ultrasound, was still regular. When aphakia is suspected, genetic counseling is essential. Conclusion a differential diagnosis between aphakia and anophtalmia is necessary. A TORCH complex evaluation can be useful. Amniocentesis is always required. PMID:26918094

  4. Why women want prenatal ultrasound in normal pregnancy

    DEFF Research Database (Denmark)

    Gudex, Claire; Nielsen, Bentt Løwe; Madsen, Monika

    2006-01-01

    Objectives To investigate women's reasons for requesting prenatal ultrasound in the absence of clinical indications. Methods A postal questionnaire was completed by 370 pregnant women with no apparent obstetric risk factors, who had expressed a desire to have ultrasound scanning in their current...... for ultrasound were to check for fetal abnormalities (60% of women) to see that all was normal (55%) and for own reassurance (44%). Lower income was related to wanting to see the baby (P=0.028) and wanting an ultrasound picture (P=0.017); higher income was related to checking that all was normal (P=0......-003) and for own reassurance (P=0.015). Women in their first pregnancy were more likely to want themselves and the father to see the baby (P=0.001); women who had given birth previously were more likely to want reassurance (P=0.002), as were women with a previous miscarriage or induced abortion. Women who believed...

  5. Two sibs with Wiedemann-Rautenstrauch syndrome: possibilities of prenatal diagnosis by ultrasound.

    Science.gov (United States)

    Castiñeyra, G; Panal, M; Lopez Presas, H; Goldschmidt, E; Sánchez, J M

    1992-01-01

    A girl with Wiedemann-Rautenstrauch syndrome was born to a non-consanguineous couple. During the pregnancy, growth retardation particularly in the biparietal and abdominal diameters but not the femoral length was detected through serial ultrasound scans. When the woman became pregnant again, in spite of having been assessed as having a 25% risk of recurrence, the prenatal findings seen in her previous pregnancy led us to suggest sequential echography and a similar pattern of growth retardation was shown. After termination, the male fetus was found to be affected by Wiedemann-Rautenstrauch syndrome. This case shows that ultrasound examination can be a useful tool in the prenatal diagnosis of this rare, autosomal recessive syndrome. Images PMID:1619643

  6. Prenatal ultrasound and fetal MRI: The comparative value of each modality in prenatal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Pugash, Denise [Department of Radiology, University of British Columbia, Vancouver (Canada)], E-mail: dpugash@cw.bc.ca; Brugger, Peter C. [Integrative Morphology Group, Centre of Anatomy and Cell Biology, Medical University of Vienna, Waehringerstrasse 13, 1090 Vienna (Austria); Bettelheim, Dieter [University Clinics of Obstetrics and Gynaecology, Medical University of Vienna, Waehringerguertel 18-20, 1090 Wien (Austria); Prayer, Daniela [University Clinics of Radiodiagnostics, Medical University of Vienna, Waehringerguertel 18-20, 1090 Wien (Austria)

    2008-11-15

    Fetal MRI is used with increasing frequency as an adjunct to ultrasound (US) in prenatal diagnosis. In this review, we discuss the relative value of both prenatal US and MRI in evaluating fetal and extra-fetal structures for a variety of clinical indications. Advantages and disadvantages of each imaging modality are addressed. In summary, MRI has advantages in demonstrating pathology of the brain, lungs, complex syndromes, and conditions associated with reduction of amniotic fluid. At present, US is the imaging method of choice during the first trimester, and in the diagnosis of cardiovascular abnormalities, as well as for screening. In some conditions, such as late gestational age, increased maternal body mass index, skeletal dysplasia, and metabolic disease, neither imaging method may provide sufficient diagnostic information.

  7. Prenatal Sex Selection and Missing Girls in China: Evidence from the Diffusion of Diagnostic Ultrasound

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    Chen, Yuyu; Li, Hongbin; Meng, Lingsheng

    2013-01-01

    How much of the increase in sex ratio (male to female) at birth since the early 1980s in China is attributed to increased prenatal sex selection? This question is addressed by exploiting the differential introduction of diagnostic ultrasound in the country during the 1980s, which significantly reduced the cost of prenatal sex selection. We…

  8. Prenatal Sex Selection and Missing Girls in China: Evidence from the Diffusion of Diagnostic Ultrasound

    Science.gov (United States)

    Chen, Yuyu; Li, Hongbin; Meng, Lingsheng

    2013-01-01

    How much of the increase in sex ratio (male to female) at birth since the early 1980s in China is attributed to increased prenatal sex selection? This question is addressed by exploiting the differential introduction of diagnostic ultrasound in the country during the 1980s, which significantly reduced the cost of prenatal sex selection. We…

  9. The clinical utility of non-invasive prenatal testing in pregnancies with ultrasound anomalies

    NARCIS (Netherlands)

    Beulen, Lean; Faas, Brigitte H W; Feenstra, Ilse; van Vugt, John M G; Bekker, Mireille N

    OBJECTIVE: This study aims to evaluate the application of non-invasive prenatal testing (NIPT) as an alternative to invasive diagnostic prenatal testing for pregnancies with abnormal ultrasound findings. METHOD: A retrospective analysis was performed of 251 single and multiple pregnancies at high

  10. Clinical utility of non-invasive prenatal testing in pregnancies with ultrasound anomalies

    NARCIS (Netherlands)

    Beulen, L.; Faas, B.H.W.; Feenstra, I.; Vugt, J.M.G. van; Bekker, M.N.

    2017-01-01

    OBJECTIVE: To evaluate the application of non-invasive prenatal testing (NIPT) as an alternative to invasive diagnostic prenatal testing in pregnancies with abnormal ultrasound findings. METHODS: This was a retrospective analysis of 251 singleton and multiple pregnancies at high risk for fetal

  11. Prenatal Diagnosis and Postnatal Ultrasound Findings of Cloacal Anomaly: A Case Report

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    Lívia Teresa Moreira Rios

    2012-01-01

    Full Text Available Cloacal malformation is an extremely rare fetal pathological condition that presents as a variety of defects. It predominantly affects females, with prevalence of 1 in 50,000 births. Prenatal ultrasonography on a 20-year-old caucasian woman (G4P1A2 at 33 weeks of pregnancy showed the fetus having a large cystic mass in the lower abdomen with a single septum, bilateral hydronephrosis, ambiguous genitalia, and a single umbilical artery. The pregnancy developed accentuated oligohydramnios, and presence of a fetal brain-sparing effect was diagnosed using arterial Doppler velocimetry. The newborn showed abdominal distension, ambiguous genitalia, and rectal atresia, with a single perineal opening. Pelvic ultrasound done on the first day after delivery revealed the presence of a large retrovesical septated cystic mass of dense content in the fetal abdomen, and bilateral hydronephrosis. Hysterotomy was performed, and 70 mL of dense liquid was drained through an abdominal colostomy. The infant died on the 27th day of life as a result of infectious complications. Prenatal diagnosing of female urogenital anomalies is usually difficult because of their rarity, different types of manifestation, and lack of characteristic ultrasound signs. Presence of a septated cyst with dense content in the fetal abdomen confirms the finding of hydrometrocolpos, thus raising clinical suspicion of a cloacal anomaly.

  12. Prenatal ultrasound and magnetic resonance imaging depiction of a small sublingual ranula.

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    Tamaru, Shunsuke; Kikuchi, Akihiko; Ono, Kyoko; Kita, Mariko; Horikoshi, Tsuguhiro; Takagi, Kimiyo

    2010-01-01

    Prenatal diagnosis of a congenital ranula has rarely been reported. We describe the case of a small ranula depicted on prenatal sonogram and magnetic resonance imaging, in which we could confirm the intact airway. Although the size of the ranula noted in our fetus was the smallest among the cases reported in the English literature, both of these imaging modalities clearly presented typical diagnostic features present on both ultrasound and magnetic resonance imaging.

  13. Prenatal diagnosis of Pallister-Killian syndrome in young woman: ultrasound indicators and confirmation by FISH.

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    Kolarski, Milenko; Joksić, Gordana; Beres, Maja; Krstić, Aleksandar; Joksić, Ivana; Dobrojević, Boris; Nikić, Slavko

    2009-03-01

    We report the first case of Pallister-Killian syndrome diagnosed prenatally in Western Balkan region where one of the ultrasound markers was intrauterine growth restriction. During routine ultrasound control of the pregnancy at 21st gestation week (second pregnancy of the 25 year old woman) symmetrical intrauterine growth restriction (IUGR), short long bones, ventriculomegaly and oligoamnion were noted. Amniotic fluid was examined cytogenetically. Fetal karyotype obtained by GTG banding of amniocytes revealed mosaic female karyotype 46,XX/47,XX,+mar (F-like). C-banding indicated that F-like marker does not belong to F, E or G chromosomal group. Employing targeted FISH with arm-specific probe for chromosome 12, tetrasomy 12p was confirmed. Fetal lymphocytes revealed normal female karyotype. This case showed that i(12p) could be found in pregnancy of young woman, not only in those of advanced age, as usually reported in the literature. This case also showed that intrauterine growth restriction could be one of the ultrasound markers associated with Pallister-Killian syndrome.

  14. Absence of prenatal ultrasound surveillance: Data from the Portuguese congenital anomalies registry.

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    Correia, Sandrina; Machado, Ausenda; Braz, Paula; Rodrigues, Ana Paula; Matias-Dias, Carlos

    2016-06-01

    In Portugal, prenatal care guidelines advocate two prenatal ultrasound scans for all pregnant women. Not following this recommendation is considered inadequate prenatal surveillance. The National Registry of Congenital Anomalies (RENAC in Portuguese) is an active population-based registry and an important instrument for the epidemiological surveillance of congenital anomalies (CA) in Portugal. Regarding pregnancies with CA, this study aims to describe the epidemiology of absent prenatal ultrasound scans and factors associated with this inadequate surveillance. A cross-sectional comparative study from 2008 to 2013 was carried out using data from RENAC. Associations of nonuptake of prenatal ultrasound screening with socio-demographic health behaviors and obstetric history data were evaluated using multiple logistic regression. Potential confounders were investigated and included if they changed the crude odds ratio estimate by at least 10% after adjustment by the Mantel-Haenszel method. The statistical significance level was set at 5%. Overall, 6090 notifications of congenital anomalies were reported to RENAC, and 2% of the pregnant women reported no prenatal ultrasound screening surveillance. These women were on average aged 30.0 years, and 52.8% had no professional occupation. The odds of not performing an ultrasound scan during their pregnancy increased 2.47 times with lack of professional activity, 4.67 times in non-Caucasian women, and decreased 46% for any previous miscarriage. For pregnant women who did not receive an ultrasound screening examination during pregnancy, the strongest statistically associated factors were professional occupation, ethnicity, and number of miscarriages in previous gestations. Birth Defects Research (Part A) 106:489-493, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  15. Persistent cloaca presenting with a perineal cyst: Prenatal ultrasound and magnetic resonance imaging findings

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    Chih-Ping Chen

    2012-04-01

    Full Text Available A 40-year-old, primigravid woman presented at 23 weeks of gestation for evaluation of an extra-abdominal echogenic cystic mass of the fetus. Amniocentesis revealed a karyotype of 46,XX. Prenatal ultrasound showed a two-vessel umbilical cord, hydrocolpos, and distended bladder, urethra, and colon, and a perineal cystic mass. The kidneys and amniotic fluid amount were normal. Fetal magnetic resonance imaging revealed ascites, hydrocolpos, distended urinary bladder and colon, high rectum, and a perineal cyst. The fetus postnatally manifested persistent cloaca. The perineum was distended and smooth, without patent anal, vaginal, and urethral openings. The external genitalia were ambiguous with no labia majora, labia minora, or clitoris. The perineal cyst had a very small single orifice. We suggest that cloacal anomalies be considered in any female fetus with hydrocolpos, distended bladder and colon, ascites, and a perineal cyst.

  16. Correlation between prenatal diagnosis by ultrasound and fetal autopsy findings in second-trimester abortions

    DEFF Research Database (Denmark)

    Hauerberg, Laura; Skibsted, Lillian; Graem, Niels;

    2012-01-01

    We evaluated the correlation between prenatal diagnosis by ultrasound and autopsy findings, based on 52 second-trimester pregnancies terminated due to fetal malformations or chromosome aberrations diagnosed at a gestational age of 12-25 weeks. In 24 pregnancies, there was full agreement between u...

  17. Congenital epulis: prenatal imaging with MRI and ultrasound

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    Roy, Sylvain; Patenaude, Yves G. [Department of Diagnostic Radiology, CHUS-Hopital Fleurimont, 3001 12 Ave Nord, J1H 5N4, Fleurimont, Quebec (Canada); Sinsky, Anna [Department of Diagnostic Radiology, UNC School of Medicine, 3322 Old Infirmary Building, NC 27599-7510, Chapel Hill (United States); Williams, Bruce [Department of Surgery, Montreal Children' s Hospital, Room C1139, 2300 Tupper Street, H3H 1P3, Montreal, Quebec (Canada); Desilets, Valerie [Department of Obstetrics and Gynecology, Royal Victoria Hospital, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec (Canada)

    2003-11-01

    Congenital epulis is an uncommon benign tumor that originates from the alveolar ridge in newborns. It is also known as congenital gingival granular cell tumor. Although there have been around 200 reports of its postnatal diagnosis, this oral tumor has rarely been diagnosed prenatally. We present fetal MRI and Doppler prenatal imaging of an infant with two congenital epulides (simultaneous involvement of superior and inferior maxillas). (orig.)

  18. Prenatal 3D Ultrasound Diagnostics in Cleidocranial Dysplasia

    DEFF Research Database (Denmark)

    Hermann, NV; Hove, HD; Jørgensen, C

    2009-01-01

    A 34-year-old Caucasian woman with cleidocranial dysplasia (CCD) and a known family history of CCD was referred for an ultrasound examination in the first trimester of her second pregnancy. Molecular genetic analysis of the RUNX2 gene was non-informative. A routine 2D ultrasound examination carried...... in the calvarial midline and missing nasal bones, are easily recognizable using 3D ultrasound as early as in week 15. Copyright (C) 2009 S. Karger AG, Basel....

  19. [Prenatal ultrasound diagnosis of complex heart abnormality in routine screening].

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    Kronich, W; Salzer-Muhar, U; Strigl, E; Gerstner, G J

    1990-02-01

    Case report on a severe cardial malformation associated with trisomia 21, diagnosed by ultrasound-screening in the 34th week of gestation. Further diagnostic evaluation of the case and therapeutic management are described. The problems of modern malformation diagnostics by routine ultrasound scanning in pregnancy are discussed.

  20. Prenatal ultrasound screening: false positive soft markers may alter maternal representations and mother-infant interaction.

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    Sylvie Viaux-Savelon

    Full Text Available BACKGROUND: In up to 5% of pregnancies, ultrasound screening detects a "soft marker" (SM that places the foetus at risk for a severe abnormality. In most cases, prenatal diagnostic work-up rules out a severe defect. We aimed to study the effects of false positive SM on maternal emotional status, maternal representations of the infant, and mother-infant interaction. METHODOLOGY AND PRINCIPAL FINDINGS: Utilizing an extreme-case prospective case control design, we selected from a group of 244 women undergoing ultrasound, 19 pregnant women whose foetus had a positive SM screening and a reassuring diagnostic work up, and 19 controls without SM matched for age and education. In the third trimester of pregnancy, within one week after delivery, and 2 months postpartum, we assessed anxiety, depression, and maternal representations. Mother-infant interactions were videotaped during feeding within one week after delivery and again at 2 months postpartum and coded blindly using the Coding Interactive Behavior (CIB scales. Anxiety and depression scores were significantly higher at all assessment points in the SM group. Maternal representations were also different between SM and control groups at all study time. Perturbations to early mother-infant interactions were observed in the SM group. These dyads showed greater dysregulation, lower maternal sensitivity, higher maternal intrusive behaviour and higher infant avoidance. Multivariate analysis showed that maternal representation and depression at third trimester predicted mother-infant interaction. CONCLUSION: False positive ultrasound screenings for SM are not benign and negatively affect the developing maternal-infant attachment. Medical efforts should be directed to minimize as much as possible such false diagnoses, and to limit their psychological adverse consequences.

  1. Prenatal Ultrasound Diagnosis of Congenital Talipes Equinovarus in Bogota (Colombia) Between 2003 and 2012.

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    Rosselli, Pablo; Nossa, Sergio; Huérfano, Elina; Betancur, Germán; Guzmán, Yuli; Castellanos, Cristal; Morcuende, Jose

    2015-01-01

    Congenital Talipes Equinovarus (CTEV) or clubfoot is one of the most common congenital abnormalities(1,2). Early diagnosis by means of ultrasonography allows an opportune intervention and improves the deformity's correction prognosis. To describe patients diagnosed with CTEV by means of prenatal sonographies between 2003 and 2012 in Bogotá (Colombia) at both the Institute de Ortopedia Infantil Roosevelt (IOIR) and one of the authors' private office. A descriptive, retrospective study on the focus population was made. The equality of the data of the quantitative variables in distance measure was analysed by the Kolmogorov-Smirnov test. For the variables "prenatal diagnoses" and "days from the start of the treatment" the Mann-Whitney U test was used. Finally, an analysis was made by means of the SPSS Statistics software package, version 18.0. 178 patients met the selection criteria. 34.3% of the patients had a prenatal diagnosis by ultrasonography (n=61). Regarding the number of prenatal ultrasounds performed, there were statistically significant differences between the patients with a CTEV prenatal diagnoses and those whose diagnoses came after birth, being higher in the first group (p<0.001). The number of days before the treatment started once the pre or postnatal diagnosis was done was also a subject of study. Significant differences were found in the treatment start between patients with a prenatal diagnosis (mean of 9.9 days) and those diagnosed after birth (mean of 30 days) (p<0.001). prenatal diagnosis by foetal ultrasonography contributes to an early detection of musculoskeletal abnormalities such as CTEV and promotes an early intervention of the patient.

  2. Genomic SNP array as a gold standard for prenatal diagnosis of foetal ultrasound abnormalities

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    Srebniak Malgorzata I

    2012-03-01

    Full Text Available Abstract Background We have investigated whether replacing conventional karyotyping by SNP array analysis in cases of foetal ultrasound abnormalities would increase the diagnostic yield and speed of prenatal diagnosis in clinical practice. Findings/results From May 2009 till June 2011 we performed HumanCytoSNP-12 array (HCS (http://www.Illumina.com analysis in 207 cases of foetal structural abnormalities. HCS allows detecting unbalanced genomic abnormalities with a resolution of about 150/200 kb. All cases were selected by a clinical geneticist after excluding the most common aneuploidies by RAD (rapid aneuploidy detection. Pre-test genetic counselling was offered in all cases. In 24/207 (11,6% foetuses a clinically relevant genetic abnormality was detected. Only 8/24 abnormalities would have been detected if only routine karyotyping was performed. Submicroscopic abnormalities were found in 16/207 (7,7% cases. The array results were achieved within 1-2 weeks after amniocentesis. Conclusions Prenatal SNP array testing is faster than karyotyping and allows detecting much smaller aberrations (~0.15 Mb in addition to the microscopic unbalanced chromosome abnormalities detectable with karyotyping (~ > 5 Mb. Since karyotyping would have missed 66% (16/24 of genomic abnormalities in our cohort, we propose to perform genomic high resolution array testing assisted by pre-test counselling as a primary prenatal diagnostic test in cases of foetal ultrasound abnormalities.

  3. 45,X/46,XY mosaicism: the role of ultrasound in prenatal diagnosis and counselling.

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    Lazebnik, N; Filkins, K A; Jackson, C L; Linn, K B; Doshi, N N; Hogge, W A

    1996-11-01

    The purpose of this study was to assess the benefit of ultrasound evaluation for fetuses with prenatally diagnosed 45,X/46,XY mosaicism. The charts of all patients who underwent chorionic villus sampling and/or amniocentesis between 1 March 1990 and 31 October 1995 were screened for 45,X/46,XY mosaicism. Cases were divided on the basis of the results of the confirmatory amniocentesis into two groups: (1) confined placental mosaicism (n = 4); and (2) true fetal 45,X/46,XY mosaicism (n = 4). All patients underwent high-resolution detailed ultrasound study between 16 and 22 weeks. If the initial ultrasound study failed to visualize fetal genitalia, scanning was repeated in 2 weeks. Chromosome analysis was carried out on the newborn's skin to confirm the prenatal result. Six cases were found to have 45,X/46,XY mosaicism on chorionic villus sampling. Amniocentesis indicated a normal 46,XY male karyotype for three fetuses and true fetal 45,X/46,XY mosaicism for two cases. One patient declined follow-up amniocentesis. At birth, this newborn was documented to have normal male genitalia and a 46,XY karyotype. An additional two cases underwent amniocentesis only and were documented to have 45,X/46,XY mosaicism. High-resolution detailed ultrasound study between 16 and 22 weeks revealed seven fetuses with normal male genitalia and one fetus with ambiguous genitalia. Of the four neonates with true 45,X/46,XY mosaicism this was the only one found to have ambiguous genitalia. We conclude that the work-up of patients with 45,X/46,XY mosaicism should include ultrasound study to look for ambiguous genitalia. This allows appropriate counselling regarding the natural history of the condition and aids in the planning for management in the postnatal period.

  4. Prenatal ultrasound heating impacts on fluctuations in haematological analysis of Oryctolagus cuniculus.

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    Ahmad Zaiki, Farah Wahida; Md Dom, Sulaiman; Abdul Razak, Hairil Rashmizal; Hassan, Hamzah Fansuri

    2013-10-01

    Prenatal Ultrasound (US) is commonly used as a routine procedure on pregnant women. It is generally perceived as a safe procedure due to the use of non-ionizing radiation. However, the neurotoxicity of diagnostic prenatal US was detected to have a correlation with high susceptibility to early developing fetus. This research involved in vivo experimental model by using 3(rd) trimester pregnant Oryctolagus cuniculus and exposing them to US exposures for 30, 60, and 90 minutes at their gestational day (GD) 28-29. The output power and intensities, spatial peak temporal average intensity (ISPTA) of US were varied from 0.4 to 0.7 W and 0.13 to 0.19 W/cm(2) respectively were tested initially in free-field, water. Haematological analysis was carried out to detect any changes in blood constituents. Statistically significant differences were detected in red blood cell (RBC) count (Pheating in causing defects on studied animal.

  5. Prenatal ultrasound screening of congenital heart disease in an unselected national population: a 21-year experience.

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    Marek, Jan; Tomek, Viktor; Skovránek, Jan; Povysilová, Viera; Samánek, Milan

    2011-01-01

    To determine the prevalence and spectrum of congenital heart disease (CHD) and the impact of a national prenatal ultrasound screening programme on outcome in a well-characterised population. A comprehensive registry was created of all paediatric and fetal patients with CHD over a 21-year period (1986-2006) in the Czech Republic. The centralised healthcare system enabled confirmation of prenatal and postnatal findings clinically and by post mortem. In the entire cohort of 9475 fetuses referred for detailed cardiac evaluation, 1604 (16.9%) had CHD, of which 501 (31.2%) had additional extracardiac anomalies. In the pregnancies which continued, 59 (8.6%) of 685 fetuses died in utero, and 626 (91.4%) babies were born alive. Prenatal detection rate was highest in double outlet right ventricle (77.3%) and hypoplastic left heart (50.6%). Detection rate increased significantly (p<0.001) for 12/17 lesions comparing 1986-1999 and 2000-2006. In recent years, detection of hypoplastic left heart reached 95.8% while transposition of the great arteries was diagnosed antenatally in only 25.6%. The nationwide prenatal ultrasound screening programme enabled detection of major cardiac abnormalities in 1/3 of patients born with any CHD and 80% of those with critical forms. Nevertheless, owing to the severity of lesions and associated extracardiac anomalies, the overall mortality of antenatally diagnosed CHD remains high. These findings are important for the understanding natural history of CHD for the establishing of screening programmes in Europe.

  6. Accreta placentation: a systematic review of prenatal ultrasound imaging and grading of villous invasiveness.

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    Jauniaux, Eric; Collins, Sally L; Jurkovic, Davor; Burton, Graham J

    2016-12-01

    Determining the depth of villous invasiveness before delivery is pivotal in planning individual management of placenta accreta. We have evaluated the value of various ultrasound signs proposed in the international literature for the prenatal diagnosis of accreta placentation and assessment of the depth of villous invasiveness. We undertook a PubMed and MEDLINE search of the relevant studies published from the first prenatal ultrasound description of placenta accreta in 1982 through March 30, 2016, using key words "placenta accreta," "placenta increta," "placenta percreta," "abnormally invasive placenta," "morbidly adherent placenta," and "placenta adhesive disorder" as related to "sonography," "ultrasound diagnosis," "prenatal diagnosis," "gray-scale imaging," "3-dimensional ultrasound", and "color Doppler imaging." The primary eligibility criteria were articles that correlated prenatal ultrasound imaging with pregnancy outcome. A total of 84 studies, including 31 case reports describing 38 cases of placenta accreta and 53 series describing 1078 cases were analyzed. Placenta accreta was subdivided into placenta creta to describe superficially adherent placentation and placenta increta and placenta percreta to describe invasive placentation. Of the 53 study series, 23 did not provide data on the depth of villous myometrial invasion on ultrasound imaging or at delivery. Detailed correlations between ultrasound findings and placenta accreta grading were found in 72 cases. A loss of clear zone (62.1%) and the presence of bridging vessels (71.4%) were the most common ultrasound signs in cases of placenta creta. In placenta increta, a loss of clear zone (84.6%) and subplacental hypervascularity (60%) were the most common ultrasound signs, whereas placental lacunae (82.4%) and subplacental hypervascularity (54.5%) were the most common ultrasound signs in placenta percreta. No ultrasound sign or a combination of ultrasound signs were specific of the depth of accreta

  7. Prenatal Diagnosis of Amniotic Band Syndrome in the Third Trimester of Pregnancy using 3D Ultrasound

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    Luciano Marcondes Machado Nardozza

    2012-01-01

    Full Text Available Amniotic band syndrome is characterized by a build-up of bands and strings of fibrous tissue that adhere to the fetus and can compress parts of the fetus, thus causing malformations and even limb amputation while the fetus is still in the uterus. The clinical manifestations are extremely variable and their extent may range from a single abnormality, like a constriction ring, to multiple abnormalities. Such abnormalities are generally diagnosed at the end of the first or the beginning of the second trimester using two-dimensional ultrasonography (2DUS. Three-dimensional ultrasonography (3DUS in rendering mode allows spatial analysis of the fetus and amniotic band, thus enabling better comprehension of this pathological condition and better counseling for the parents. There has not previously been any evidence to show that 3DUS would be useful in cases of late diagnosis (third trimester of amniotic band syndrome. In the present case, a primigravid woman underwent her second obstetric ultrasound scan in the 34 th week, from which we observed two bands in contact with the right forearm, but with normal movement of this limb and its fingers. 3DUS made it possible to see the spatial relationship of these bands to the fetal body, thereby confirming their adherence to the limb. After the birth, the prenatal diagnosis of amniotic band syndrome without limb constriction was confirmed. A surgical procedure was carried out on the third day after birth to excise the bands, and the newborn was then discharged in a good general condition.

  8. Estimation of prenatal aorta intima-media thickness from ultrasound examination

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    Veronese, E.; Tarroni, G.; Visentin, S.; Cosmi, E.; Linguraru, M. G.; Grisan, E.

    2014-10-01

    Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data. The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed. Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%). The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT. Preliminary results have been presented in E Veronese, E Cosmi, S Visentin, E Grisan: 'Semiautomatic estimation

  9. The value of fast MR imaging as an adjunct to ultrasound in prenatal diagnosis

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    Breysem, L.; Bosmans, H.; Dymarkowski, S.; Demaerel, P.; Vanbeckevoort, D.; Smet, M. [Department of Radiology, University Hospitals, Herestraat 49, 3000, Leuven (Belgium); Schoubroeck, D.Van; Witters, I.; Deprest, J. [Department of Obstetrics and Gynecology, University Hospitals, Herestraat 49, 3000, Leuven (Belgium); Vanhole, C.; Casaer, P. [Department of Pediatrics, University Hospitals, Herestraat 49, 3000, Leuven (Belgium)

    2003-07-01

    The aim of this study was to evaluate the role of MR imaging of the fetus to improve sonographic prenatal diagnosis of congenital anomalies. In 40 fetuses (not consecutive cases) with an abnormality diagnosed with ultrasound, additional MR imaging was performed. The basic sequence was a T2-weighted single-shot half Fourier (HASTE) technique. Head, neck, spinal, thoracic, urogenital, and abdominal fetal pathologies were found. This retrospective, observational study compared MR imaging findings with ultrasonographic findings regarding detection, topography, and etiology of the pathology. The MR findings were evaluated as superior, equal to, or inferior compared with US, in consent with the referring gynecologists. The role of these findings in relation to pregnancy management was studied and compared with postnatal follow-up in 30 of 40 babies. Fetal MRI technique was successful in 36 of 39 examinations and provided additional information in 21 of 40 fetuses (one twin pregnancy with two members to evaluate). More precise anatomy and location of fetal pathology (20 of 40 cases) and additional etiologic information (8 of 40 cases) were substantial advantages in cerebrospinal abnormalities [ventriculomegaly, encephalocele, vein of Galen malformation, callosal malformations, meningo(myelo)cele], in retroperitoneal abnormalities (lymphangioma, renal agenesis, multicystic renal dysplasia), and in neck/thoracic pathology [cervical cystic teratoma, congenital hernia diaphragmatica, congenital cystic adenomatoid lung malformation (CCAM)]. This improved parental counseling and pregnancy management in 15 pregnancies. In 3 cases, prenatal MRI findings did not correlate with prenatal ultrasonographic findings or neonatal diagnosis. The MRI provided a more detailed description and insight into fetal anatomy, pathology, and etiology in the vast majority of these selected cases. This improved prenatal parental counseling and postnatal therapeutic planning. (orig.)

  10. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome.

    Science.gov (United States)

    Schmidauer, Christoph; Sojer, Martin; Seppi, Klaus; Stockner, Heike; Högl, Birgit; Biedermann, Birgit; Brandauer, Elisabeth; Peralta, Cecilia M; Wenning, Gregor K; Poewe, Werner

    2005-10-01

    In patients with Parkinson's disease, hyperechogenicity of the substantia nigra using transcranial ultrasound has been related to increased tissue concentrations of iron. Recently, deficient iron transport mechanisms in substantia nigra neurons have been described in postmortem tissue of patients with restless legs syndrome (RLS). This study was performed to study substantia nigra echogenicity in RLS patients compared with normal control subjects and Parkinson's disease patients. RLS patients had significantly reduced midbrain areas of hyperechogenicity compared with control subjects, and even more markedly reduced hyperechogenicity compared with Parkinson's disease patients. These findings lend further support to nigral iron deficiency as a pathogenetic factor in RLS.

  11. Is ultrasound alone enough for prenatal screening of trisomy 18? A single centre experience in 69 cases over 10 years.

    Science.gov (United States)

    Lai, S; Lau, W L; Leung, W C; Lai, F K; Chin, R

    2010-11-01

    To evaluate ultrasound scan and other prenatal screening tests for trisomy 18 in a regional obstetric unit and to review the management approach for women with positive trisomy 18 screening results. Prenatal diagnosis databases were accessed to identify fetuses that had confirmed trisomy 18 karyotypes or were at high risk for trisomy 18 on second-trimester biochemical screening or first-trimester combined screening tests over a period of 10 years from 1 September 1997 to 30 September 2007. Sixty-nine women were confirmed to have trisomy 18 fetuses by karyotyping either prenatally (n = 61) or postnatally/post-miscarriage (n = 8) during the study period. The detection rate of ultrasound scan ≤ 14 weeks and 18 to 21 weeks to detect trisomy 18 was 92.7 and 100%, respectively. A total of 80 and 87% of fetuses had two or more ultrasound abnormalities detected in the ≤ 14 weeks and 18 to 21 weeks anomaly scans, respectively. Forty-eight women screened positive for trisomy 18 by second-trimester biochemical screening with human chorionic gonadotrophin (hCG) and alpha fetoprotein (AFP). Only one was true positive (positive predictive value = 1/48 or 2%). Eleven women screened positive for trisomy 18 by first-trimester combined screening with nuchal translucency scan and maternal serum for pregnancy-associated plasma protein A (PAPP-A) and hCG between 11 and 13 + 6 weeks. Three were true positive (positive predictive value = 3/11 or 27%). All four cases with positive screening had ultrasound abnormalities. Ultrasound scan for fetal anomalies is the most effective screening test for trisomy 18. A policy of conservative management for women with positive second-trimester biochemical screening or first-trimester combined screening for trisomy 18 is reasonable in the absence of ultrasound fetal abnormalities. Unnecessary invasive tests can be avoided.

  12. Utility of ultrasound and magnetic resonance imaging in prenatal diagnosis of placenta accreta: A prospective study

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    Bhawna Satija

    2015-01-01

    Full Text Available Context: Placenta accreta is the abnormal adherence of the placenta to the uterine wall and the most common cause for emergency postpartum hysterectomy. Accurate prenatal diagnosis of affected pregnancies allows optimal obstetric management. Aims: To summarize our experience in the antenatal diagnosis of placenta accreta on imaging in a tertiary care setup. To compare the accuracy of ultrasound (USG with color Doppler (CDUS and magnetic resonance imaging (MRI in prenatal diagnosis of placenta accreta. Settings and Design: Prospective study in a tertiary care setup. Materials and Methods: A prospective study was conducted on pregnant females with high clinical risk of placenta accreta. Antenatal diagnosis was established based on CDUS and MRI. The imaging findings were compared with final diagnosis at the time of delivery and/or pathologic examination. Statistical Analysis Used: The sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV were calculated for both CDUS and MRI. The sensitivity and specificity values of USG and MRI were compared by the McNemar test. Results: Thirty patients at risk of placenta accreta underwent both CDUS and MRI. Eight cases of placenta accreta were identified (3 vera, 4 increta, and 1 percreta. All patients had history of previous cesarean section. Placenta previa was present in seven out of eight patients. USG correctly identified the presence of placenta accreta in seven out of eight patients (87.5% sensitivity and the absence of placenta accreta in 19 out of 22 patients (86.4% specificity. MRI correctly identified the presence of placenta accreta in 6 out of 8 patients (75.0% sensitivity and absence of placenta accreta in 17 out of 22 patients (77.3% specificity. There were no statistical differences in sensitivity (P = 1.00 and specificity (P = 0.687 between USG and MRI. Conclusions: Both USG and MRI have fairly good sensitivity for prenatal diagnosis of placenta accreta

  13. Utility of ultrasound and magnetic resonance imaging in prenatal diagnosis of placenta accreta: A prospective study

    Science.gov (United States)

    Satija, Bhawna; Kumar, Sanyal; Wadhwa, Leena; Gupta, Taru; Kohli, Supreethi; Chandoke, Rajkumar; Gupta, Pratibha

    2015-01-01

    Context: Placenta accreta is the abnormal adherence of the placenta to the uterine wall and the most common cause for emergency postpartum hysterectomy. Accurate prenatal diagnosis of affected pregnancies allows optimal obstetric management. Aims: To summarize our experience in the antenatal diagnosis of placenta accreta on imaging in a tertiary care setup. To compare the accuracy of ultrasound (USG) with color Doppler (CDUS) and magnetic resonance imaging (MRI) in prenatal diagnosis of placenta accreta. Settings and Design: Prospective study in a tertiary care setup. Materials and Methods: A prospective study was conducted on pregnant females with high clinical risk of placenta accreta. Antenatal diagnosis was established based on CDUS and MRI. The imaging findings were compared with final diagnosis at the time of delivery and/or pathologic examination. Statistical Analysis Used: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for both CDUS and MRI. The sensitivity and specificity values of USG and MRI were compared by the McNemar test. Results: Thirty patients at risk of placenta accreta underwent both CDUS and MRI. Eight cases of placenta accreta were identified (3 vera, 4 increta, and 1 percreta). All patients had history of previous cesarean section. Placenta previa was present in seven out of eight patients. USG correctly identified the presence of placenta accreta in seven out of eight patients (87.5% sensitivity) and the absence of placenta accreta in 19 out of 22 patients (86.4% specificity). MRI correctly identified the presence of placenta accreta in 6 out of 8 patients (75.0% sensitivity) and absence of placenta accreta in 17 out of 22 patients (77.3% specificity). There were no statistical differences in sensitivity (P = 1.00) and specificity (P = 0.687) between USG and MRI. Conclusions: Both USG and MRI have fairly good sensitivity for prenatal diagnosis of placenta accreta; however

  14. A case of prenatal diagnosis of fetal hydantoin syndrome by ultrasound

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    Gollop Thomaz Rafael

    1999-01-01

    Full Text Available Fetal hydantoin syndrome (FHS is a set of disruptions occasionally present in fetuses exposed in utero to phenytoin or other anticonvulsants. Administration of phenytoin in early pregnancy may impair proper psychomotor performance expected for children's development. Several combined phenotypic markers delineate the syndrome, but the presence of single clinical signs is more common. There is controversy about the etiology of FHS. Associated disruptions may be related to a deficiency in a detoxifying enzyme (epoxide hydrolase, vascular problems, and/or factors not yet known. Genetic causes are believed to influence susceptibility to the drug. This text reports an unusual pattern of malformations detected in an ultrasound scan (gastroschisis, sacral meningomyelocele, and absence of the right lower limb and in the anatomopathological study (left-side gastroschisis, sacral meningomyelocele, scoliosis, left clubfoot, absence of the right lower limb, and pectus carinatum of a fetus whose mother took phenytoin. These defects may have been provoked by exposure to the drug during embryogenesis. In view of similar malformations observed in cases of prenatal exposure to cocaine, a recognized vasoconstrictor, it is suggested that vascular disruptions of hemodynamic origin constituted the event leading to some of the anomalies caused in the developing embryo. A complication of the chorionic villus sampling procedure, used for cytogenetic analysis, is another possibility.

  15. Application of early prenatal systemic ultrasound screening in diagnosis of fetal deformity%早孕期超声筛查在胎儿结构畸形诊断中的应用

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    霍晓恺; 刘泰石; 解耀锃

    2016-01-01

    Objective To explore the clinical value of early prenatal systemic ultrasound screening in diagnosis of fetal deformity.Methods Sixty-four pregnant women who accepted prenatal ultrasound examination during 11 to 13 +6 gestational weeks in the Second People ’ s Hospital of Liaocheng City from May 2013 to May 2015 were selected to do the early prenatal ultrasound screening.Medium-term prenatal ultrasound was done among the cases of 22 -24 +6 weeks of pregnancy (continuous scan method), and the final results were tracked. Results The fetus deformity detection rates of early prenatal ultrasound screening and medium-term prenatal ultrasound in both groups were not obviously different (χ2 =1.03,P>1.03).Compared to the detection rates of single early prenatal ultrasound screening or single medium-term prenatal ultrasound, the deformity rate in the joint early prenatal ultrasound and medium-term prenatal ultrasound showed significant difference (χ2 =4.53,P<0.05; χ2 =5.39, P<0.05).There were 36 types of fetal structural deformity detected in early prenatal ultrasound.The top three were as follows: cervical cystic carcinoma and NT thickening ( 33.33%) , facial abnormality (25.00%), and anterior abdominal wall abnormality (11.11%).There were 42 types of fetal structural deformity detected in medium-term prenatal ultrasound.The top three were as follows: cardiovascular abnormalities (30.95%), facial abnormalities (21.43%), and central nervous system abnormalities (11.11%).In the results of systemic ultrasound screening in early and medium-term pregnancy, the distribution rates of all kinds of structural deformity were significantly different (χ2 value ranged 4.55 to 6.32, all P<0.05).Conclusion The detection rate of fetal structural deformity is higher in early prenatal systemic ultrasound screening which, however, cannot completely replace the medium-term ultrasound.The joint examination of early and medium-term prenatal ultrasound is suggested to improve the detection

  16. A case of ultrasound-guided prenatal diagnosis of prune belly syndrome in Papua New Guinea--implications for management.

    Science.gov (United States)

    Ome, Maria; Wangnapi, Regina; Hamura, Nancy; Umbers, Alexandra J; Siba, Peter; Laman, Moses; Bolnga, John; Rogerson, Sheryle; Unger, Holger W

    2013-05-07

    Prune belly syndrome is a rare congenital malformation of unknown aetiology and is characterised by abnormalities of the urinary tract, a deficiency of abdominal musculature and bilateral cryptorchidism in males. We report a case of prune belly syndrome from Papua New Guinea, which was suspected on pregnancy ultrasound scan and confirmed upon delivery. A 26-year-old married woman, Gravida 3 Para 2, presented to antenatal clinic in Madang, Papua New Guinea, at 21(+5) weeks' gestation by dates. She was well with no past medical or family history of note. She gave consent to participate in a clinical trial on prevention of malaria in pregnancy and underwent repeated ultrasound examinations which revealed a live fetus with persistent megacystis and anhydramnios. Both mother and clinicians agreed on conservative management of the congenital abnormality. The mother spontaneously delivered a male fetus weighing 2010 grams at 34 weeks' gestation with grossly abnormal genitalia including cryptorchidism, penile aplasia and an absent urethral meatus, absent abdominal muscles and hypoplastic lungs. The infant passed away two hours after delivery. This report discusses the implications of prenatal detection of severe congenital abnormalities in PNG. This first, formally reported, case of prune belly syndrome from a resource-limited setting in the Oceania region highlights the importance of identifying and documenting congenital abnormalities. Women undergoing antenatal ultrasound examinations must be carefully counseled on the purpose and the limitations of the scan. The increasing use of obstetric ultrasound in PNG will inevitably result in a rise in prenatal detection of congenital abnormalities. This will need to be met with adequate training, referral mechanisms and better knowledge of women's attitudes and beliefs on birth defects and ultrasound. National medicolegal guidance regarding induced abortion and resuscitation of a fetus with severe congenital abnormalities may

  17. Acrania-anencephaly associated with hypospadias. Prenatal ultrasound and MRI diagnosis and molecular folate metabolism pathway analysis.

    Science.gov (United States)

    Tonni, Gabriele; Centini, Giovanni; Bonasoni, Maria Paola; Ventura, Alessandro; Pattacini, Pierpaolo; Cavalli, Pietro

    2012-12-01

    Acrania may occur as a single isolated malformation or associated with extracranial defects. Hypospadias is one of the most common congenital abnormalities of the genitalia frequently missed on prenatal sonograms. Second trimester two- and three-dimensional ultrasound and MRI diagnosis with necropsy and folate metabolism pathway analysis. The mechanisms leading to closure of both neural and urethral tubes, are far from being demonstrated, and molecular studies of this very rare association are lacking although it might be based on a common genetic mechanism, leading to a disturbed development pathway at the molecular level.

  18. Prenatal Diagnosis of EEC Syndrome with "Lobster Claw" Anomaly by 3D Ultrasound.

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    Rios, Livia T; Araujo Júnior, Edward; Caetano, Ana C R; Nardozza, Luciano M; Moron, Antonio F; Martins, Marília G

    2012-01-01

    THE EEC SYNDROME IS A GENETIC ANOMALY CHARACTERIZED BY THE TRIAD: ectodermal dysplasia (development of anomalies of the structures derived from the embryonic ectodermal layer), ectrodactyly (extremities, hands and feet malformations) and cleft lip and/or palate; these malformations can be seen together or in isolation. The prenatal diagnosis can be made by two-dimensional ultrasonography (2DUS) that identifies the facial and/or limb anomalies, most characteristic being the "lobster-claw" hands. The three-dimensional ultrasonography (3DUS) provides a better analysis of the malformations than the 2DUS. A 25-year-old primigravida, had her first transvaginal ultrasonography that showed an unique fetus with crow-rump length of 47 mm with poorly defined hands and feet,. She was suspected of having sporadic form of EEC syndrome. The 2DUS performed at 19 weeks confirmed the EEC syndrome, showing a fetus with lobster-claw hands (absence of the 2(nd) and 3(rd) fingers), left foot with the absence of the 3rd toe and the right foot with syndactyly, and presence of cleft lip/palate. The 3DUS defined the anomalies much better than 2DUS including the lobster-claw hands.

  19. Use of a portable system with ultrasound and blood tests to improve prenatal controls in rural Guatemala.

    Science.gov (United States)

    Crispín Milart, Patricia Hanna; Diaz Molina, César Augusto; Prieto-Egido, Ignacio; Martínez-Fernández, Andrés

    2016-09-13

    Maternal and neonatal mortality figures remain unacceptably high worldwide and new approaches are required to address this problem. This paper evaluates the impact on maternal and neonatal mortality of a pregnancy care package for rural areas of developing countries with portable ultrasound and blood/urine tests. An observational study was conducted, with intervention and control groups not randomly assigned. Rural areas of the districts of Senahu, Campur and Carcha, in Alta Verapaz Department (Guatemala). The control group is composed by 747 pregnant women attended by the community facilitator, which is the common practice in rural Guatemala. The intervention group is composed by 762 pregnant women attended under the innovative Healthy Pregnancy project. That project strengthens the local prenatal care program, providing local nurses training, portable ultrasound equipment and blood and urine tests. The information of each pregnancy is registered in a medical exchange tool, and is later reviewed by a gynecology specialist to ensure a correct diagnosis and improve nurses training. No maternal deaths were reported within the intervention group, versus five cases in the control group. Regarding neonatal deaths, official data revealed a 64 % reduction for neonatal mortality. A 37 % prevalence of anemia was detected. Non-urgent referral was recommended to 70 pregnancies, being fetal malpresentation the main reported cause. Impact data on maternal mortality (reduction to zero) and neonatal mortality (NMR was reduced to 36 %) are encouraging, although we are aware of the limitations of the study related to possible biasing and the small sample size. The major reduction of maternal and neonatal mortality provides promising prospects for these low-cost diagnostic procedures, which allow to provide high quality prenatal care in isolated rural communities of developing countries. This research was not registered because it is an observational study where the assignment of

  20. Accuracy of Ultrasound in Detection of Gross Prenatal Central Nervous System Anomalies after the Eighteenth Week of Gestation

    Directory of Open Access Journals (Sweden)

    M. Tahmasebi

    2007-10-01

    Full Text Available Background/Objective: Ultrasound (US detection of prenatal central nervous system (CNS anatomic anomalies is very important in making decision about therapeutic termination. In the present study, the accuracy of US in detection of gross prenatal CNS anatomic anomalies has been investigated."nPatients and Methods: 3012 pregnant women were scanned after 18 weeks of gestation by an expert operator in a referring center. All delivered fetuses were followed after birth through clinical examination and sonography."nResults: In this study, the accuracy of US in detection of gross CNS anatomic anomalies of fetuses after 18 weeks gestation was found to be 100%. The sensitivity, specificity, positive and negative predictive values of US were 100%. In sonographic examination of these 3012 pregnant women, 36 fetuses were detected with CNS anomalies, some of whom had more than one anomaly. Gross CNS anomalies observed included microcephaly, hydrocephaly, anencephaly, holoprosencephaly, ventriculomegaly, meningocele, encephalocele, lissencephaly, agenesis of corpus callosum, bilateral choroid plexus cysts and hypoplastic cerebellum."nConclusion: US is highly operator dependent and operator experience may be the most determinant affecting the results. Sonographic scanning after 18 weeks of gestation is associated with the best results.

  1. Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero.

    Science.gov (United States)

    Drews, Barbara; Roellig, Kathleen; Menzies, Brandon R; Shaw, Geoff; Buentjen, Ina; Herbert, Catherine A; Hildebrandt, Thomas B; Renfree, Marilyn B

    2013-01-01

    Marsupials have a functional placenta for a shorter period of time compared to that of eutherian species, and their altricial young reach the teats without any help from the mother. We have monitored the short intrauterine development of one marsupial, the tammar wallaby, with high-resolution ultrasound from reactivation of the 100-cell diapausing blastocyst to birth. The expanding blastocyst could be visualized when it had reached a diameter of 1.5 mm. From at least halfway through pregnancy, there are strong undulating movements of the endometrium that massage the expanding vesicle against the highly secretory endometrial surface. These unique movements possibly enhance exchange of uterine secretions and gases between the mother and embryo. There was a constant rate of development measured ultrasonographically from mid-gestation, regardless of when the blastocyst reactivated. Interestingly climbing movements by the fetus began in utero about 3 days before birth, mimicking those required to climb to the pouch.

  2. Ultrasound and MR imaging findings in prenatal diagnosis of craniosynostosis syndromes

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    Rubio, Eva I.; Blask, Anna; Bulas, Dorothy I. [Children' s National Health System, Department of Radiology, Washington, DC (United States)

    2016-05-15

    Craniosynostosis syndromes are uncommonly encountered in the prenatal period. Identification is challenging but important for family counseling and perinatal management. This series examines prenatal findings in craniosynostosis syndromes, comparing the complementary roles of US and MRI and emphasizing clues easily missed in the second trimester. Six prenatal cases evaluated from 2002 through 2011 were retrospectively reviewed. Referral history, gestational age, and sonographic and MRI findings were reviewed by three pediatric radiologists. Abnormalities of the calvarium, hands, feet, face, airway and central nervous system were compared between modalities. The diagnosis was Apert syndrome in three, Pfeiffer syndrome in two and Carpenter syndrome in one. The gestational age at evaluation ranged from 21 to 33 weeks. All six were evaluated by MRI and US, with two undergoing repeat evaluation in the third trimester, yielding a total of eight MRIs and US exams. The referral history suggested cloverleaf skull in two cases but did not suggest craniosynostosis syndrome in any case. In four, the referral suggested central nervous system (CNS) findings that were not confirmed by MRI; additional CNS findings were discovered in the remaining two. In four cases, developing turricephaly resulted in a characteristic ''lampshade'' contour of the fetal head. Hypertelorism and proptosis were present in five, with proptosis better appreciated by MRI. Digit abnormalities were present in all, seen equally well by MRI and US. Lung abnormalities in the second trimester in one fetus resolved by the third trimester. Prenatal diagnosis of craniosynostosis syndromes is difficult prior to the third trimester. MRI and US have complementary roles in evaluation of these patients. (orig.)

  3. [Telecommunication--a medium for improving prenatal diagnosis and gynecologic ultrasound diagnosis? Initial experiences].

    Science.gov (United States)

    Sohn, C; Beldermann, F; Wallwiener, D; Lepold, H; Bastert, G

    1997-01-01

    To establish the requirements for real-time transfer of an ultrasound examination via telecommunication network the following tests were performed: The ultrasound data were transferred from the video out of an ultrasound system to a basis terminal of the German Telekom. Simultaneously, an external video camera filmed the positioning and movements of the ultrasound transducer, and the verbal comments were recorded. These informations were transmitted to Karlsruhe and London, where they were rerouted to the examination room in Heidelberg. Here the informations were received on a Telecom reception unit/terminal and compared directly with the initial signal. The quality was sufficient if the moving ultrasound images and the camera image of the transducer as well as the oral comment were transmitted over 2 parallel ISDN lines. The delay to a real-time transmission of the examination process is only in the range of milliseconds. If only one ISDN line is used, the image quality is unsatisfactory, three parallel lines do not bring significant improvement of image quality. Telemedicine seems a new possibility to bring the knowledge of specialized centers to the practicing gynaecologists thus avoiding unnecessary referrals. Still unanswered, however, are the problem of liability, data protection and costs.

  4. Prenatal diagnosis of lissencephaly: A case report

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    Cerovac Nataša

    2016-01-01

    Full Text Available Introduction. Lissencephaly (“smooth brain” forms a major group of brain malformations due to abnormal neuronal migration. It can cause severe intellectual and motor disability and epilepsy in children. The prenatal diagnosis of this malformation is rare. Case report. We presented a case of the prenatal diagnosis of lissencephaly. A 30-year old pregnant woman was reffered to the hospital at the week 35 of gestation for magnetic resonance imaging (MRI after an ultrasound examination demonstrated fetal cerebral ventriculomegaly. Fetal MRI of the brain showed “smooth”, agyrya cortex. The female infant was born at term with birth weight of 2,500 g and Apgar score 8, showing global developmental delay. Postnatal ultrasound and MRI confirmed classical lissencephaly. She is now 8 years old and has spastic quadriparesis, mental retardation and epilepsy. Conclusion. Confirmation of the ultrasound diagnosis with MRI is desirable for the prenatal diagnosis of lissencephaly.

  5. The image analysis of prenatal ultrasound and MRI of fetal right congenital diaphragmatic hernia%胎儿先天性右侧膈疝的产前超声及磁共振图像分析

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    董素贞; 朱铭; 钟玉敏; 张弘; 潘慧红

    2015-01-01

    Objective To summarize the image features of prenatal ultrasound and MRI of fetal right congenital diaphragmatic hernia (CDH). Methods Between June 2007 and December 2014, eight fetuses with suspicious right pleural abnormalities diagnosed by conventional prenatal ultrasound received MRI examination within 24 to 48 hours after ultrasonography at Shanghai Children′s Medical Center. The imaging sequences included steady-state free-precession (SSFP) sequence, single-shot turbo spin echo (SSTSE) sequence and T1-weighted imaging (T1WI) sequence. Prenatal ultrasound and MRI findings were compared with postnatal imaging diagnoses, surgery or autopsy. The image features of prenatal ultrasound and MRI of fetal right CDH were analyzed. Results Among the eight cases of fetal prenatal ultrasound, 7 cases presented right pleural abnormal heterogeneous echo, 1 case showed right pleural effusion. Fetal prenatal MRI showed seven cases of right-sided pleural abnormalities, included a portion of the liver in 2 cases, a portion of the bowel in 2 cases, a portion of the liver and the bowel in 3 cases. One case was with bilateral pleural abnormalities, the liver and the bowel in right thoracic cavity, a portion of the bowel in left thoracic cavity. Prenatal ultrasound and MRI findings were compared with postnatal upper gastrointestinal tract barium contrast, enhanced chest CT, surgery or autopsy. Prenatal ultrasound correctly diagnosed 4 cases of fetal right CHD, misdiagnosed right CHD as right pleural mass in 2 cases, missed 1 case of right CHD, and misdiagnosed 1 case of bilateral CHD as right CHD. MRI correctly diagnosed 7 cases of fetal right CHD and 1 case of bilateral CHD. Conclusions Prenatal ultrasound couldn′t identify the detailed contents herniated into the fetal thoracic cavity of right CDH, especially when the liver herniated into the fetal thoracic cavity. However, prenatal MRI could clearly show the hernia contents in the fetal thoracic cavity, and make the correct

  6. Ultrasound

    Science.gov (United States)

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... Last reviewed: October, 2014 Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ...

  7. Fetal brain tumors: Prenatal diagnosis by ultrasound and magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    Hérbene; José; Milani; Edward; Araujo; Júnior; Sérgio; Cavalheiro; Patrícia; Soares; Oliveira; Wagner; Jou; Hisaba; Enoch; Quinderé; Sá; Barreto; Maurício; Mendes; Barbosa; Luciano; Marcondes; Nardozza; Antonio; Fernandes; Moron

    2015-01-01

    Congenital central nervous system tumors diagnosed during pregnancy are rare, and often have a poor prognosis. The most frequent type is the teratoma. Use of ultrasound and magnetic resonance image allows the suspicion of brain tumors during pregnancy. However, the definitive diagnosis is only confirmed after birth by histology. The purpose of this mini-review article is to describe the general clinical aspects of intracranial tumors and describe the main fetal brain tumors.

  8. Prenatal ultrasound diagnosis and outcome of placenta previa accreta after cesarean delivery: a systematic review and meta-analysis.

    Science.gov (United States)

    Jauniaux, Eric; Bhide, Amar

    2017-07-01

    Women with a history of previous cesarean delivery, presenting with a placenta previa, have become the largest group with the highest risk for placenta previa accreta. The objective of the study was to evaluate the accuracy of ultrasound imaging in the prenatal diagnosis of placenta accreta and the impact of the depth of villous invasion on management in women presenting with placenta previa or low-lying placenta and with 1 or more prior cesarean deliveries. We searched PubMed, Google Scholar, clinicalTrials.gov, and MEDLINE for studies published between 1982 and November 2016. Criteria for the study were cohort studies that provided data on previous mode of delivery, placenta previa, or low-lying placenta on prenatal ultrasound imaging and pregnancy outcome. The initial search identified 171 records, of which 5 retrospective and 9 prospective cohort studies were eligible for inclusion in the quantitative analysis. The studies were scored on methodological quality using the Quality Assessment of Diagnostic Accuracy Studies tool. The 14 cohort studies included 3889 pregnancies presenting with placenta previa or low-lying placenta and 1 or more prior cesarean deliveries screened for placenta accreta. There were 328 cases of placenta previa accreta (8.4%), of which 298 (90.9%) were diagnosed prenatally by ultrasound. The incidence of placenta previa accreta was 4.1% in women with 1 prior cesarean and 13.3% in women with ≥2 previous cesarean deliveries. The pooled performance of ultrasound for the antenatal detection of placenta previa accreta was higher in prospective than retrospective studies, with a diagnostic odds ratios of 228.5 (95% confidence interval, 67.2-776.9) and 80.8 (95% confidence interval, 13.0-501.4), respectively. Only 2 studies provided detailed data on the relationship between the depth of villous invasion and the number of previous cesarean deliveries, independently of the depth of the villous invasion. A cesarean hysterectomy was performed in

  9. Use of high‐frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc‐deficient mice

    Science.gov (United States)

    Autuori, Maria C.; Pai, Yun J.; Stuckey, Daniel J.; Savery, Dawn; Marconi, Anna M.; Massa, Valentina; Lythgoe, Mark F.; Copp, Andrew J.; David, Anna L.

    2017-01-01

    Abstract Objective We used non‐invasive high‐frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and non‐ketotic hyperglycinemia (NKH). Method Using HFUS, we imaged embryos carrying loss of function alleles of Gldc encoding glycine decarboxylase, a component of the glycine cleavage system in mitochondrial folate metabolism, which is known to be associated with cranial NTDs and NKH in humans. We serially examined the same litter during the second half of embryonic development and quantified cerebral structures. Genotype was confirmed using PCR. Histology was used to confirm ultrasound findings. Results High‐frequency ultrasound allowed in utero detection of two major brain abnormalities in Gldc‐deficient mouse embryos, cranial NTDs (exencephaly) and ventriculomegaly (corresponding with the previous finding of post‐natal hydrocephalus). Serial ultrasound allowed individual embryos to be analysed at successive gestational time points. From embryonic day 16.5 to 18.5, the lateral ventricle volume reduced in wild‐type and heterozygous embryos but increased in homozygous Gldc‐deficient embryos. Conclusion Exencephaly and ventriculomegaly were detectable by HFUS in homozygous Gldc‐deficient mouse embryos indicating this to be an effective tool to study CNS development. Longitudinal analysis of the same embryo allowed the prenatal onset and progression of ventricle enlargement in Gldc‐deficient mice to be determined. © 2017 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd. PMID:28056489

  10. Ultrasound

    Science.gov (United States)

    Ultrasound is a type of imaging. It uses high-frequency sound waves to look at organs and ... liver, and other organs. During pregnancy, doctors use ultrasound to view the fetus. Unlike x-rays, ultrasound ...

  11. Diagnóstico pré-natal de displasia tanatofórica: papel do ultrassom fetal Prenatal diagnosis of thanatophoric dysplasia: role of the fetal ultrasound

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo G Zen

    2011-09-01

    diagnosis and highlighting the importance of the fetal ultrasound in the identification of fetus with this dysplasia. CASE DESCRIPTION: The patient is the second son of young parents without family history of genetic diseases. The fetal ultrasound performed with 35 weeks of gestation showed polyhydramnios, prominent forehead and disproportion between skull and trunk, with thoracic hypoplasia and shortening of long bones, suggestive of thanatophoric dysplasia. At birth, the child was small and presented: hypotonia, macrocephaly, large fontanel, middle face hypoplasia, bulging eyes, nevus flammeus in the nose and eyelids, low nasal bridge, micrognathia, short neck and thorax, and an important shortening of arms, forearms, thighs and legs. Radiographic evaluation showed a great transverse diameter of the skull, thorax with short ribs and diminished vertebral bodies, shortening and deformity of the long bones of upper and lower limbs (with curved femora and hypoplasia of the pelvis. These features confirmed the prenatal diagnosis of thanatophoric dysplasia. The patient died few days after birth due to respiratory insufficiency. COMMENTS: Fetal ultrasound is a non-invasive method capable of diagnosing several bone dysplasias, including the thanatophoric one. The intrauterine diagnosis allows the differential diagnosis of the condition as well as the genetic counseling for the family.

  12. 产前超声在诊断胎儿隐性脊柱裂中的价值%Prenatal ultrasound diagnosis of fetal spina bifida occulta

    Institute of Scientific and Technical Information of China (English)

    许玲; 徐延峰; 鞠志叶; 董发进; 胡冰; 接连利; 吴乃森

    2009-01-01

    目的 探讨隐性脊柱裂的超声表现,提高产前超声对此类畸形的认识.方法 回顾性分析9例产前诊断为胎儿隐性脊柱裂的超声表现,并与放射影像学资料对比,总结其声像图特点.结果 产前超声诊断隐性脊柱裂9例,经尸解、X线摄片或出生后MRI证实,8例诊断正确,另1例为显性脊柱裂.胎儿隐性脊柱裂的超声表现具有特征性,其声像图特点为:①胎儿脊柱正常生理弯曲消失;②病变部位椎骨骨化中心排列异常,椎板缺如,椎管开放;③背部皮肤连续完整,无囊状物交出及胎头形状改变.结论 超声检查是诊断隐性脊柱裂的可靠方法.%Objective To investgate the ultrasound appearance of prenatal spina bifida occulta (SBO) to improve the recognition of this kind of abnormality. Methods A total of 9 cases of SBO which were diagnosticated by prenatal ultrasound were reviewed retrospectively. The results were compared with radiological and pathological results. Results Prenatal ultrasound diagnosed 9 SBO cases, which were confirmed by autopsy, X-ray or MRI (8 SBO cases and 1 spinal bifida manifesta cases). The sonogram features of SBOwere the disaooearance of physiological curvature of spine,abnormal arrangement of intravertebral body in diseased region, the absence of vertebral plate with opening vertebral arch, and the normal skin outline on the back, with out outstanding cyst or the skull Conclusion Prenatal ultrasound is a reliability method in the diagnosis of SBO.

  13. 血管前置的产前超声筛查与诊断%Prenatal ultrasound screening and diagnosis of vasa previa

    Institute of Scientific and Technical Information of China (English)

    李胜利; 陈秀兰; 文华轩

    2011-01-01

    血管前置是导致围产儿死亡的一个危险因素,经阴道分娩围产儿死亡率高.超声检查是产前诊断血管前置最可靠且简便、易推广的检查方法.当产前超声检查发现低置胎盘、双叶胎盘、副胎盘、多叶胎盘、多胎妊娠、帆状胎盘等高危发病因素时,需详细检查宫颈内口,常规的检查方法是经腹超声检查,当因胎先露阻挡等原因显示宫颈内口不满意时,需结合经会阴超声检查或经阴道超声检查;经阴道超声检查是该3种检查方法中最可靠的显示方法,但合并阴道活动性出血或宫颈机能不全时不宜使用.对于产前诊断血管前置的病例,建议于临产前行选择性剖宫产术.%Vasa previa is a dangerous factor which may result in fetal demise. Vaginal delivery may lead to high fetal mortality. Ultrasound is the most reliable, simple and generalized way for diagnosis of prenatal vasa previa. If the following high risk factors are detected by prenatal ultrasound, such as low lying placenta, bi-lobed placenta, succenturiate lobe, multi-lobed placenta, multiple pregnancy and velamentous insertion of the cord, the internal cervical os is necassary for examination. Transabdominal ultrasound is the routine way to observe the internal cervical os. But if internal cervical os is not satisfied to observe internal cervical os because of fetal presentation,transperineal or transvaginal ultrasound is recommended. Transvaginal ultrasound is the most reliable way. However, it is not recommended to perform once the mother is complicated with active bleeding or cervical incompetence. Elective caesarean section should be offered prior to the onset of labour for cases that have been diagnosed of prenatal vasa previa.

  14. Prenatal diagnosis of craniomaxillofacial malformations: a characterization of phenotypes in trisomies 13, 18, and 21 by ultrasound and pathology.

    NARCIS (Netherlands)

    Ettema, A.M.; Wenghoefer, M.; Hansmann, M.; Carels, C.E.L.; Borstlap, W.A.; Berge, S.J.

    2010-01-01

    OBJECTIVE: To determine the relationship between trisomies 13, 18, and 21 and craniofacial malformations detected by prenatal sonography. DESIGN: During a 29-year period (1976 through 2004), prenatal sonographic findings of 69 fetuses with trisomy 13; 171 fetuses with trisomy 18; 302 fetuses with tr

  15. Prenatal diagnosis of craniomaxillofacial malformations: a characterization of phenotypes in trisomies 13, 18, and 21 by ultrasound and pathology.

    NARCIS (Netherlands)

    Ettema, A.M.; Wenghoefer, M.; Hansmann, M.; Carels, C.E.L.; Borstlap, W.A.; Berge, S.J.

    2010-01-01

    OBJECTIVE: To determine the relationship between trisomies 13, 18, and 21 and craniofacial malformations detected by prenatal sonography. DESIGN: During a 29-year period (1976 through 2004), prenatal sonographic findings of 69 fetuses with trisomy 13; 171 fetuses with trisomy 18; 302 fetuses with tr

  16. 产前超声诊断胎儿主动脉闭锁%Prenatal ultrasound diagnosis of fetal aortic atresia

    Institute of Scientific and Technical Information of China (English)

    许燕; 何敬海; 接连利; 程建; 高翔; 刘清华

    2012-01-01

    目的 探讨产前超声诊断胎儿主动脉闭锁的临床价值.方法 回顾性分析9例经引产后尸检证实的主动脉闭锁胎儿的产前超声心动图表现,总结其声像图特征.结果 9例主动脉闭锁胎儿声像图显示升主动脉及主动脉弓细窄7例,升主动脉及主动脉弓显示不清2例,彩色多普勒血流显像9例胎儿均显示主动脉与左心室无血流连接,主动脉弓显示反向血流.9例胎儿中6例伴发左心发育不良,2例伴发室间隔缺损,左心室发育良好,1例伴发完全型房室间隔缺损.9例胎儿检出时平均孕龄(26.0±2.6)周,孕龄最小者仅为孕16周.结论 产前超声诊断胎儿主动脉闭锁具有重要临床价值;升主动脉、主动脉弓细窄或显示不清,主动脉与左心室无血流连接及主动脉弓内反向血流是主要诊断依据;彩色多普勒血流显像有助于早期诊断.%Objective To investigate the clinical value of prenatal ultrasonography in diagnosing fetal aortic atresia.Methods Ultrasound images of 9 cases with fetal aortic atresia confirmed by autopsy were retrospectively analysed and summarized.Results Fetal echocardiography showed ascending aorta and aortic arch were thin in seven cases and unclear in two cases.Color Doppler flow imaging showed fetal aorta no blood connection with left ventricle and reverse blood flow in aortic arch among all 9 cases.There were 6 cases associated with hypoplastic left heart syndrome,two cases associated with ventricular septal defect and well-developed left ventricle,one case complicated with complete atrioventricular septal defect.Nine cases were detected at average gestational age (26.0 ± 2.6) weeks,minimum gestational age was only 16 weeks pregnant.Conclusions Prenatal ultrasound diagnosis of fetal aortic atresia has important clinical value.Ascending aorta and aortic arch are thin or unclear,no blood flow connection between fetal aorta and left ventricle and reverse blood flow in aortic arch are

  17. Is the Presence of the Father of the Baby during First Prenatal Ultrasound Study Visit Associated with Improved Pregnancy Outcomes in Adolescents and Young Adults?

    Science.gov (United States)

    Lazebnik, Rina; Kuper-Sassé, Margaret

    2016-01-01

    This study examined whether the presence of the father of the baby (FOB) at the first prenatal ultrasound study (US) visit of pregnant adolescents and young adults (AYA) is a marker for improved pregnancy outcomes. Charts of 400 pregnant AYA aged 14–22 years seen at an academic maternity hospital were assessed retrospectively for support persons brought to prenatal US visits. Logistic regression analysis was used to examine the association between FOB presence and gestational age and birth weight. Of 400 charts with support person recorded, 298 charts with first US visit data, singleton birth, and complete gestational data available were analyzed. FOB was present at 30.2% of visits, while the parent of the mother was present at 34.2% of visits. With FOB present, 3.3% of infants were born preterm (gestational age < 37 weeks) compared with 10.5% of infants with FOB absent (p = 0.04). Patients with FOB present also had significantly earlier gestational age at the first US visit (15 weeks) than those who did not (19 weeks; p = 0.02). For AYA, the presence of FOB at initial prenatal US visits is a predictor of improved pregnancy outcome and likely represents increased support during the pregnancy.

  18. The effectiveness of ultrasound screening in the prenatal diagnosis of fetal malformation%胎儿肢体畸形的产前超声诊断价值

    Institute of Scientific and Technical Information of China (English)

    吕小利; 薛玉; 许建萍; 张歆; 吴新财; 陈宝定

    2015-01-01

    目的:探讨超声筛查诊断胎儿肢体畸形的价值。方法超声筛查8368名孕16~34周的孕妇,运用二维连续顺序追踪超声检测法(SCSA)结合三维超声表面及透明成像模式检查胎儿肢体。结果引产后胎儿肢体畸形22例,产前超声检出21例[9例双足内翻,1例一足外翻,2例四肢短小畸形,1例左小腿缺如,1例双上肢前臂缺如,3例肢体姿势异常,1例双侧桡骨缺失,3例多指(趾)]。其中19例合并其他畸形,1例漏诊及3例部分漏诊。结论二维超声连续顺序追踪检测法结合三维超声表面及透明成像法是产前检出胎儿肢体畸形的有效方法。%Objective To evaluate the effectiveness of ultrasound screening and diagnosis of fetal limb defor-mities. Methods Ultrasound screening of 8 368 cases of pregnancy 16 to 34 weeks pregnant , focus on detection of fetus′limbs by using systematic continuous sequence approach (SCSA) combined with three-dimensional ultrasound. Results After development of fetal limb deformity in 22 cases, prenatal ultrasound detected 21 cases, including 9 cases of varus feet,1 case of valgus foot , 2 cases of short limb deformity, 1 case with left leg absent,1 case of upper forearm absent, 1 cases of pairs of limb posture abnormalities, 3 cases of pairs of limb posture abnormalities, 1 case of Congenital radiu deficiency ,and 3 cases of multiple fingers (toes), with 19 cases complicate with other malformations,1 case of missed diagnosis and missed parts of 3 cases. Conclusion The method of systematic continuous sequence ap-proach (SCSA) in two-dimensional ultrasound combined with three-dimensional ultrasound screening are effective tools for use in prenatal identification ofetal limb deformities.

  19. Prenatal ultrasound diagnosis of fetalbody stalk anomaly%胎儿体蒂异常的产前超声诊断

    Institute of Scientific and Technical Information of China (English)

    毛利萍

    2015-01-01

    目的:探讨产前超声诊断胎儿体蒂异常的价值。方法回顾性分析本院产前超声诊断的7例胎儿体蒂异常超声声像图特点及随访结果。结果7例胎儿均合并有多种畸形,7例均有前腹壁严重缺损及腹腔多个脏器外突、脊柱侧弯、脐带过短;6例伴有肢体缺失或肢体畸形;3例合并单脐动脉;4例于宫腔内见羊膜带;2例伴有骶尾部脊柱裂并相应的颅内改变;1例合并有心脏室间隔缺损。7例胎儿中仅2例合并羊水过少。结论产前超声检查是诊断胎儿体蒂异常的可靠方法,值得在临床推广应用。%Objective: To investigate the prenatal ultrasound diagnosis of fetal body stalk anomaly value. Methods A retrospective analysis of our hospital 7 cases of prenatal ultrasound diagnosis of fetal body stalk anomaly ultrasound sonographic features and follow-up results.Results: 7 cases of fetus were combined with multiple malformations, 7 cases were anterior abdominal wall defect of abdominal multiple viscera and severe external condyle, scoliosis, umbilical cord is too short; 6 cases with limb loss or limb malformations; single umbilical artery of 3 cases with; 4 cases in the intrauterine amniotic bands; 2 cases of intracranial with lumbosacral the tail spinal column fracture and the corresponding change ;there were 1 cases with ventricular septal defect. 7 cases of fetal in only 2 of cases witholigohydramnios.Conclusion: Prenatal ultrasound diagnosis of fetal is a reliable method of body stalk anomaly, it is worth to popularize in the clinical application.

  20. 产前超声检查在诊断染色体非整倍体异常胎儿中的价值%Application of prenatal ultrasound in the diagnosis of chromosomal aneuploidy abnormalities

    Institute of Scientific and Technical Information of China (English)

    钟惟娜; 邓学东

    2012-01-01

    目的 探讨产前超声检查在非整倍体异常胎儿诊断中的价值.方法 对2009年9月至2011年12月在我院经羊水细胞染色体核型分析诊断为非整倍体异常的24例胎儿产前超声异常声像图特征进行总结分析.结果 24例羊水细胞染色体核型分析确诊为非整倍体异常的胎儿中超声显示异常20例(83.3%,20/24),包括21-三体9例(9/13)、18-三体3例(3/3)、13-三体3例(3/3)、45,X 5例(5/5).其中单发畸形4例(20%,4/20),多发畸形13例(65%,13/20),仅表现为超声软标志异常3例(15%,3/20).18-三体、13-三体及45,X胎儿均有超声可检出的明显结构畸形或异常,21-三体胎儿3例,仅表现为超声软标志异常.24例非整倍体异常胎儿中以心脏畸形检出例数居多(41.7%,10/24),而颈部淋巴水囊瘤是45,X胎儿一个极其重要的超声标志.结论 非整倍体异常胎儿常伴有异常的超声声像图表现,部分还有相应的典型超声畸形谱,超声作为非侵入性检查技术对于非整倍体异常胎儿的诊断有重要临床意义.%Objective To investigate the clinical application of prenatal ultrasound in the diagnosis of chromosomal aneuploidy abnormalities . Methods Ultrasound imaging features in 24 aneuploidy abnormal fetuses which were diagnosed by amniocentesis in our hospital from September 2009 to December 2011 were analyzed retrospectively. Results Twenty -four cases of aneuploidy abnormalities dectected by amniocentesis were examined by prenatal ultrasound. Of these cases, twenty were found abnormalities , including 9 with trisomy 21,3 with trisomy 18,3 with trisomy 13 and 5 with 45 ,X monomer. Prenatal ultrasound showed single malformation in 4 cases, multi-malformation in 13 cases and separate ultrasonographic soft markers in 3 cases. Fetuses with trisomy 18,trisomy 13 and 45,X monomer were all had obvious structural abnormalities detected by ultrasound , otherwise, 3 cases of trisomy 21 had only ultrasonographic soft markers. In

  1. Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure

    Science.gov (United States)

    Salomäki-Myftari, Henriikka; Vähätalo, Laura H.; Ailanen, Liisa; Pietilä, Sami; Laiho, Asta; Hänninen, Arno; Pursiheimo, Juha-Pekka; Munukka, Eveliina; Rintala, Anniina; Savontaus, Eriika; Pesonen, Ullamari; Koulu, Markku

    2016-01-01

    Background Prenatal metformin exposure has been shown to improve the metabolic outcome in the offspring of high fat diet fed dams. However, if this is evident also in a genetic model of obesity and whether gut microbiota has a role, is not known. Methods The metabolic effects of prenatal metformin exposure were investigated in a genetic model of obesity, mice overexpressing neuropeptide Y in the sympathetic nervous system and in brain noradrenergic neurons (OE-NPYDβH). Metformin was given for 18 days to the mated female mice. Body weight, body composition, glucose tolerance and serum parameters of the offspring were investigated on regular diet from weaning and sequentially on western diet (at the age of 5–7 months). Gut microbiota composition was analysed by 16S rRNA sequencing at 10–11 weeks. Results In the male offspring, metformin exposure inhibited weight gain. Moreover, weight of white fat depots and serum insulin and lipids tended to be lower at 7 months. In contrast, in the female offspring, metformin exposure impaired glucose tolerance at 3 months, and subsequently increased body weight gain, fat mass and serum cholesterol. In the gut microbiota, a decline in Erysipelotrichaceae and Odoribacter was detected in the metformin exposed offspring. Furthermore, the abundance of Sutterella tended to be decreased and Parabacteroides increased. Gut microbiota composition of the metformin exposed male offspring correlated to their metabolic phenotype. Conclusion Prenatal metformin exposure caused divergent metabolic phenotypes in the female and male offspring. Nevertheless, gut microbiota of metformin exposed offspring was similarly modified in both genders. PMID:27681875

  2. 产前超声诊断胎儿出生缺陷的临床分析%The Clinical Study on the Diagnosis of Fetal Birth Defect by Prenatal Ultrasound Examination

    Institute of Scientific and Technical Information of China (English)

    马澜竹

    2015-01-01

    目的:探究产前超声诊断对胎儿出生缺陷的临床分析。方法选取2012年4月~2013年12月在我院就诊的627例孕妇进行产前的超声诊断,观察超声检查的图像。结果产前超声诊断的符合率为95.12%,漏诊率为4.9%,符合率较高,准确率高,有统计学意义(P<0.05)。结论产前的超声诊断能够准确检查出胎儿的出生缺陷问题,提高优生优育,为胎儿出生缺陷干预重要有效的方法。%Objective Clinical study on the diagnosis of fetal birth defect by prenatal ultrasound examination is to be investigated. Methods Chose 627 pregnant women who were received and treated in hospital from April 2012 to December 2013 and get them tested by prenatal ultrasound examination. And then make an observation on ultrasound image. Results The accuracy of prenatal ultrasound examination was up to 95.12%,and misdiagnosis probability was 4.9%; the prenatal diagnosis was of high accuracy and its outcome had statistic value(P<0.05). Conclusion Prenatal ultrasound examination is of high accuracy in diagnosis of fetal birth defect which is beneficial to improve sound birth and superior nurture; it is a quite effective way to prevent from fetal birth defect.

  3. Feasibility Study on Prenatal Cardiac Screening Using Four-Dimensional Ultrasound with Spatiotemporal Image Correlation: A Multicenter Study.

    Directory of Open Access Journals (Sweden)

    Liqing Zhao

    Full Text Available This study aimed at investigating the feasibility of using the spatiotemporal image correlation (STIC technology for prenatal cardiac screening, finding factors that influence the offline evaluation of reconstructed fetal heart, and establishing an optimal acquisition scheme.The study included 452 gravidae presenting for routine screening at 3 maternity centers at 20-38 gestational weeks. The factors influencing the quality of STIC volume data were evaluated using t test, chi-square test, and logistic regression analysis. The predictive power was evaluated using the receiver operating characteristic (ROC curve.Among the 452 fetuses enrolled, 353 (78.1% were identified as successful and 99 (21.9% as failure of evaluation of the reconstructed fetal heart. The total success rate of qualified STIC images was 78.1%. The display rates of reconstructed cardiac views were 86.5% (four-chamber view, 92.5% (left ventricular outflow tract view, 92.7% (right ventricular outflow tract view, 89.9% (three-vessel trachea view, 63.9% (aortic arch view, 81.4% (ductal arch view, 81% (short-axis view of great vessels, 80.1% (long-cava view, and 86.9% (abdominal view. A logistic regression analysis showed that more than 28 gestational weeks [OR = 0.39 (CI 95% 0.16, 0.19, P = 0.035], frequent fetal movements [OR = 0.37 (CI 95% 0.16, 0.87, P = 0.022], shadowing [OR = 0.36 (CI 95% 0.19, 0.72, P = 0.004], spine location at 10-2 o'clock [OR = 0.08 (CI 95% 0.02, 0.27, P = 0.0], and original cardiac view [OR = 0.51 (0.25, 0.89, P = 0.019] had a significant impact on the quality of STIC. The area under the ROC curve was 0.775.Fetal cardiac-STIC seems a feasible tool for prenatal screening of congenital heart diseases. The influence factors on the quality of STIC images included the intensity of training, gestational age, fetal conditions and parameter settings. The optimal acquisition scheme may improve the application and widespread use of cardiac STIC.

  4. Ultrasound

    Science.gov (United States)

    ... Saunders; 2014:chap 66. Cosgrove DO, Eckersley RJ, Harvey CJ, Lim A. Ultrasound. In: Adam A, Dixon AK, Gillard ... Northside Radiology Associates, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

  5. Prenatal magnetic resonance imaging as a useful adjunctive to ultrasound-enhanced diagnosis in case of a giant foetal tumour of the neck.

    Science.gov (United States)

    Mittermayer, C; Brugger, P C; Lee, A; Horcher, E; Hayde, M; Bernaschek, G; Prayer, D

    2005-02-01

    Large cervical masses in the prenatal period are rare and can cause life threatening situations after birth. All available diagnostic techniques should therefore be used to determine the best mode of delivery in the case of such malformation. A large cervical mass was detected by ultrasound in a 41-year-old women, gravida 4, para 3, at 29 + 5 weeks of gestation. US imaging was most consistent with the diagnosis of a large cervical teratoma, but it was not possible to sufficiently evaluate the cervical anatomy of the oropharynx and trachea. An MRI scan demonstrated a distorted oropharynx and a trachea displaced to the right and posteriorly, but not detectable from the middle of the neck up to the larynx. Based on these facts, an EXIT procedure was planned and performed at 30 + 5 weeks of gestation. Foetal MRI provided valuable anatomical information for all specialists deciding on the indication and the pre-therapeutic planning of the EXIT procedure.

  6. 胎盘植入产前超声诊断的临床应用价值%Clinical Value of Prenatal Ultrasound Diagnosis of Placenta Implantation

    Institute of Scientific and Technical Information of China (English)

    欧阳一兵; 郭晓燕; 温穗文; 余桂云

    2014-01-01

    目的:探讨产前超声诊断在胎盘植入的临床应用价值。方法回顾性分析34例经由临床及病理学证实为胎盘植入的孕妇相关资料,分析其多普勒超声检查的声像学特征,及胎盘植入与产后出血及胎盘的关系。结果经由产前超声诊断提示共11例确诊,占比32.4%,出现漏诊23例,占比67.6%;经产前超声诊断提示胎盘植入的11例患者的影像学特征主要有:胎盘后间隙部分或者全部消失,胎盘有内漩涡流形成,胎盘附着处的子宫肌层菲薄及胎盘异常性增厚等,产后大出血与非产后大出血的胎盘植入发生率为(56.3%vs11.1%),胎盘前置与非胎盘前置的胎盘植入发生率为(71.4%vs 5.0%),前壁胎盘与非前壁胎盘的发生率为(53.3%vs15.8%),P<0.05。结论经超声检查对胎盘植入进行产前的诊断,对预防产后出血、保障母婴平安有着重要的价值。%Objective To explore the clinical value of prenatal ultrasound diagnosis of placenta implantation .Methods Doing retrospective analysis of 34 cases with placenta implantation confirmed by clinical and pathological pregnant relevant information, analyzing features of Doppler ultrasonographic and relationship of postpartum hemorrhage with placenta implantation placenta .Results Among 34 cases, 11 cases were diagnosed as placenta implantation by prenatal ultrasound , accounting for 32.4%.23 cases were missed , accounting for 66.7%.The main imaging characteristics were as follows:some or all of clearance of behind placenta disappeared , there was vortex flow in the placenta formation ,and there was myometrium meager attachment of the placenta and placental abnormalities thickening in the 11 pla-centa implantation of 34 cases patients diagnosed by prenatal ultrasound.Incidence of placenta accreta in postpartum hemorrhage patients and non-postpartum hemorrhage patients was 56.3%vs11.1%,incidence of placenta accreta

  7. SUBSTANCE-ABUSING PREGNANT WOMEN: PRENATAL INTERVENTION USING ULTRASOUND CONSULTATION AND MENTALIZATION TO ENHANCE THE MOTHER-CHILD RELATIONSHIP AND REDUCE SUBSTANCE USE.

    Science.gov (United States)

    Pajulo, Helena; Pajulo, Marjukka; Jussila, Heidi; Ekholm, Eeva

    2016-07-01

    Substance-abusing pregnant and parenting women are considered one of the most challenging, but important, target groups for developing early parenting interventions. Some valuable efforts to develop such interventions have been made in the organizational sector in Finland. However, there is a great need for new ways of work that would simultaneously concentrate in substance-abuse treatment and enhance parenting in public healthcare settings. The present article describes the background, content, and protocol of a new prenatal intervention developed for substance-abusing pregnant women in a hospital setting in public healthcare. The intervention includes two new elements and pathways aimed to enhance the mothers' curiosity toward her developing child and provide motivation to stay abstinent from substance use. The pathways are interactive ultrasound consultation and a new pregnancy diary, both using a parental mentalization focus. The intervention elements, experiences from running the intervention, evaluation protocol, and general characteristics of the study sample gained (n = 90) are described and discussed. Two case vignettes from the study sample are presented, and the applicability of this prenatal work with other groups and settings is considered. © 2016 Michigan Association for Infant Mental Health.

  8. Effectiveness of advertising availability of prenatal ultrasound on uptake of antenatal care in rural Uganda: A cluster randomized trial.

    Science.gov (United States)

    Cherniak, William; Anguyo, Geoffrey; Meaney, Christopher; Yuan Kong, Ling; Malhame, Isabelle; Pace, Romina; Sodhi, Sumeet; Silverman, Michael

    2017-01-01

    In rural Uganda pregnant women often lack access to health services, do not attend antenatal care, and tend to utilize traditional healers/birth attendants. We hypothesized that receiving a message advertising that "you will be able to see your baby by ultrasound" would motivate rural Ugandan women who otherwise might use a traditional birth attendant to attend antenatal care, and that those women would subsequently be more satisfied with care. A cluster randomized trial was conducted across eight rural sub-counties in southwestern Uganda. Sub-counties were randomized to a control arm, with advertisement of antenatal care with no mention of portable obstetric ultrasound (four communities, n = 59), or an intervention arm, with advertisement of portable obstetric ultrasound. Advertisement of portable obstetric ultrasound was further divided into intervention A) word of mouth advertisement of portable obstetric ultrasound and antenatal care (one communitity, n = 16), B) radio advertisement of only antenatal care and word of mouth advertisement of antenatal care and portable obstetric ultrasound (one community, n = 7), or C) word of mouth + radio advertisement of both antenatal care and portable obstetric ultrasound (two communities, n = 75). The primary outcome was attendance to antenatal care. 159 women presented to antenatal care across eight sub-counties. The rate of attendance was 65.1 (per 1000 pregnant women, 95% CI 38.3-110.4) where portable obstetric ultrasound was advertised by radio and word of mouth, as compared to a rate of 11.1 (95% CI 6.1-20.1) in control communities (rate ratio 5.9, 95% CI 2.6-13.0, padvertising antenatal care and portable obstetric ultrasound by radio attendance was significantly improved. This study suggests that women can be motivated to attend antenatal care when offered the concrete incentive of seeing their baby.

  9. Prenatal ultrasound in diagnosis of fetal pulmornary sequestration malformations%胎儿隔离肺畸形的产前超声诊断探讨

    Institute of Scientific and Technical Information of China (English)

    李伟霞; 周宇

    2012-01-01

    Objective To explore the diagnostic value and clinical significance of ultrasonography in the fetal pulmonary sequestration (PS). Methods Fetus in late pregnancy was the line of systematic ultrasonography screening for fe-talmalformation. Routinely bilateral lung echo was observed with or without abnormal lesions and lesion characteristics, andlesions with CDFI showed internal blood supply and blood flow. Results There were 14 fetus with PS whose ultrasonography was in conformity with the pathology or imagingstudies. the coincidence rate was 82.4% (14/17), There were: 3 cases who belonged to missed diaghosisCtwo cases aspulmonary cystadenoma,one case as diaphragmatic hernia). The fetal PS is characterized'by a typical ultrasoundimage of chest or abdominal fetal echogenic mass or slightly stronger echo,triangular or leaf, the internal echouniform, border clearance, and solid strong echo from circulation artery or branch. Conclusion Prenatal ultrasound is amore accurate and reliable method in diagnosis of fetal PS, has important clinical value.%目的 探讨产前超声检查对胎儿隔离肺的诊断价值及临床意义.方法 对孕中晚期胎儿行系统性畸形筛查,常规观察双侧肺部回声,有无异常病灶及病灶特征,并用CDFI显示病灶血供来源及内部血流情况,并追踪随访产后病检结果.结果 产前诊断的17例隔离肺,经产后病理或影像学检查证实为隔离肺14例胎儿,超声诊断准确率82.4%;误诊3例(2例为肺囊腺瘤,1例隔疝).其典型声像图特征:胎儿胸腔内或腹腔内强回声或稍强回声团块、呈三角形或叶状,内部回声均匀、边界清,供血动脉来自体循环动脉或其分支.结论 产前超声检查是诊断胎儿隔离肺畸形的较准确、可靠的方法,具有重要的临床价值.

  10. Investigation on prenatal ultrasound diagnosis of fetal agenesis of septum pellucidum cavity%胎儿透明隔腔缺如的产前超声诊断

    Institute of Scientific and Technical Information of China (English)

    符燕鸣

    2015-01-01

    Objective To study the prenatal ultrasound diagnosis of fetus isolation chamber is absent . Methods Our hospital from October 2012 to October 2014 pregnant women for prenatal ultrasonic examination system between 8650 cases, including 8 cases of symptoms, the isolation chamber was absent for key observe cerebral ultrasound , ultrasonic characteristics and analyze its related abnormalities .Results All the 8 cases of fetal prenatal brain two-dimensional ultrasonic are transparent insulation cavity , its deficiency such as fetal related deformities has the following kinds: 1 ) the subcallosal sacral defect in 1 case, for lack of completeness; 2 ) holoprosencephaly in 2 cases, including leaves in 1 case, half leaf type 1 case;3) split brain malformation in 1 case;4) hole brain in 1 case; 5) type water anencephaly in 1 case; 6) severe hydrocephalus in 2 cases, including 1 case caused by midbrain aqueduct stenosis , 1 case caused by open spina bifida .Conclusions Cavity of septum pellucidum can be used as a middle and late ultrasonic observation important index of the fetal central nervous system development , if the isolation chamber is absent tend to cause various brain malformation fetus , such as frontal lesions and midline structure dysplasia .In double top diameter plane make prenatal ultrasound can observe transparent insulation cavity , it can be as an important observation methods have transparent insulation cavity.%目的:研究胎儿透明隔腔缺如的产前超声诊断。方法选取我院自2012年10月至2014年10月间进行产前系统超声检查的孕妇8650例,其中有8例透明隔腔缺如症状,对其进行颅脑超声重点观察,并且分析其相关畸形超声特征。结果所有8例胎儿的产前颅脑二维超声均未显示透明隔腔,其缺如胎儿的相关畸形有以下几种:(1)胼骶体缺失1例,为完全性缺失;(2)前脑无裂畸形2例,其中包括无叶型1例,半叶型1例;(3)脑裂畸形1

  11. Prenatal ultrasonographic findings of cloacal anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Song, Mi Jin [Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2002-09-15

    To evaluate the ultrasonographic characteristic of a rare malformation comples, Cloacal anomaly on prenatal ultrasonography. From March 1991 to July 2001, eight cases with the persistent cloaca (4 cases in female and 1 case in male) and cloacal exstrophy (3 cases) diagnosed by prenatal ultrasound examination were included, and all of them were pathologically confirmed by autopsy. One radiologist retrospectively analyzed the prenatal sonographic images, including the urinary bladder, kidney, pelvic cyst, abdominal wall defect and amount of amniotic fluid. The ultrasonographic diagnosis was established at 21.8 {+-} 7.8 weeks of gestation. The prenatal ultrasonographic findings of the persistent cloaca were absent bladder (n=2), distended bladder (n=2) and small thick bladder (n=1). Sonography of the kidney showed normal (n=2), hydronephrosis (n=1), dysplasia (n=1) and unilateral hydronephrosis with absent contralateral kidney (n=1). Four fetuses showed septated pelvic cyst; three fetuses, oligohydramnios. The prenatal ultrasonographic findings of cloacal exstrophy included absent bladder (n=3), normal kidney (n=1), hydronephrosis (n=1) and absent kidney (n=1). All fetuses with cloacal exstrophy had abdominal wall defect while two of them had oligohydramnios. A prenatal diagnosis of persistent cloaca can be confidently made when there is septated pelvic cyst combined oligohydramnios, sediments within the cyst and intraluminal calcifications. Cloacal exstrophy should be included in diagnosis if there is a low abdominal wall defect with absent urinary bladder.

  12. Prenatal diagnosis of a giant foetal lymphangioma and haemangiolymphoma in the second trimester using 2D and 3D ultrasound.

    Science.gov (United States)

    Mittermayer, C; Blaicher, W; Deutinger, J; Bernaschek, G; Lee, A

    2003-12-01

    Lymphangiomas are benign tumours of the lymphatic system. Early prenatal diagnosis is important to permit a planned delivery and provide adequate postnatal care. It thereby improves prognosis and allows the option of terminating the pregnancy if poor outcome is predicted. We report two cases, a giant haemangiolymphoma and a lymphangioma. 2D and 3D US findings are presented and differential diagnosis, therapeutic options and prognosis are discussed.

  13. 胎儿结构畸形产前超声诊断分析%Prenatal ultrasound assessment for fetal structural abnormalities

    Institute of Scientific and Technical Information of China (English)

    王凤兰; 王建华; 张云亭; 寇世和; 易建平; 杜明桢; 张伟; 周钰昆

    2015-01-01

    Objective To investigate the diagnostic value of prenatal ultrasound for fetal structural abnormalities.Methods The clinical data of 3 101 fetus with structural malformations, diagnosed by prenatal ultrasound and confi rmed after induced labor, and 856 cases of missed diagnosis were analyzed. All these data were collected in Maternal and Child Health Hospital of Tangshan City from January 2010 to June 2014. The types and number of fetal structural abnormalities were recorded. The rates of detection and missed diagnosis for the fetal structural abnormalities were calculated and the reasons for missed diagnosis were analyzed.ResultsA total of 3101 cases (4 171 positions) were diagnosed as fetal structural abnormalities by prenatal ultrasound. The detection rate was 11.51‰ (3 101/269 501). There were 856 cases (947 positions) of fetal structural abnormalities were missed, and the missed diagnosis rate was 3.18‰ (856/269 501). The incidence of fetal structural abmormalities was 14.68‰ (3 957/269 501). In terms of anatomy systems, the top five were cardiovascular system abnormalities (851 cases), the central nervous system abnormalities (691 cases), facial abnormalities (562 cases), urinary system abnormalities (476 cases), and respiratory system abnormalities (134 cases). In terms of single abnormalities, the top five were cleft lip and palate (549 cases), ventricular septal defect (519 cases), hydronephrosis (331 cases), spina bifi da (212 cases), and atrial-ventricular septal defect (163 cases). The top five of missed deformities were polydactylia/symphysodactylia (285 cases), ear deformities (108 cases), hypospadias (93 cases), foot abnormalities (92cases), and ventricular septal defect (52 cases).Conclusions There is a high detection rate for fetal structural abnormalities with prenatal ultrasound. Prenatal ultrasound is an indispensable means for the diagnosis of fetal malformation, but it also has some limitations. There is a high rate of missed diagnosis

  14. 产前超声诊断全前脑畸形的价值%The value of prenatal ultrasound diagnosis of holoprosencephaly.

    Institute of Scientific and Technical Information of China (English)

    胡翔

    2015-01-01

    Objective:To analyze the application value of prenatal ultrasonography in diagnosis of fetal holoprosencephaly. Methods:From 2009 May to 2014 year in August in our hospital for prenatal ultrasound diagnosis for clinical data of 20 cases of pregnant women of fetal holoprosencephaly. Were analyzed retrospectively, observation of fetal intracranial structure, ring structure and blood flow of the brain artery of Willis, the facial organs and other organs combined anomalies. Results:In 20 cases of fetal holoprosencephaly, 12 cases with alobar holoprosencephaly, 7 cases with semilobar holoprosencephaly, and were associated with facial deformities, mainly manifested as cyclopia, eyes from too close, single nostril nose deformity or trunk, trunk deformity, malformed and central type of cleft lip and palate at the same time; 2 cases with both hands and feet shaft multi finger (toe) malformation, 2 cases combined with omphalocele. 1 cases of phyllodes holoprosencephaly, not complicated with facial deformities and other organs. CDFI display part of the forebrain of fetal cerebral arterial circle of Willis perfusion abnormal or there is a reverse flow phenomenon, the lack of integrity of the structure. Conclusion:Prenatal ultrasound is a non invasive, sensitive in detecting fetal holoprosencephaly and malformation, and of holoprosencephaly type, is of great significance to guide the prenatal counseling and clinical treatment.%目的:分析产前超声在胎儿全前脑畸形诊断中的应用价值.方法:选择2009年5月至2014年8月在我院接受产前超声检查被诊断为胎儿全前脑畸形的20例孕妇的临床资料进行回顾性分析,观察胎儿颅内结构、大脑Willis动脉环结构及血流情况、颜面部器官以及其他器官合并畸形情况.结果:在20例全前脑畸形胎儿中,12例为无叶全前脑、7例为半叶全前脑,且均伴有颜面部畸形,主要表现为独眼畸形、眼距过近、单鼻孔、无鼻孔长鼻畸形或象鼻畸

  15. Systematic review and meta-analysis of persistent left superior vena cava on prenatal ultrasound: associated anomalies, diagnostic accuracy and postnatal outcome.

    Science.gov (United States)

    Gustapane, S; Leombroni, M; Khalil, A; Giacci, F; Marrone, L; Bascietto, F; Rizzo, G; Acharya, G; Liberati, M; D'Antonio, F

    2016-12-01

    To quantify the prevalence of chromosomal anomalies in fetuses with persistent left superior vena cava (PLSVC), assess the strength of the association between PLSVC and coarctation of the aorta and ascertain the diagnostic accuracy of antenatal ultrasound in correctly identifying isolated cases of PLSVC. MEDLINE, EMBASE, CINHAL and the Cochrane databases were searched from the year 2000 onwards using combinations of keywords 'left superior vena cava' and 'outcome'. Two authors reviewed all abstracts independently. Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale for cohort studies. The rates of the following outcomes were analyzed: chromosomal abnormalities; associated intracardiac anomalies (ICAs) and extracardiac anomalies (ECAs) diagnosed prenatally; additional ICAs and ECAs detected only at postnatal imaging or clinical evaluation but missed at prenatal imaging; and association of PLSVC and coarctation of the aorta. Meta-analyses of proportions were used to combine data. In total, 2708 articles were identified and 13 (n = 501) were included in the systematic review. Associated ICAs and ECAs were detected at the prenatal ultrasound examination or at a follow-up assessment in 60.7% (95% CI, 44.2-75.9%) and 37.8% (95% CI, 31.0-44.8%) of cases, respectively. Chromosomal anomalies occurred in 12.5% (95% CI, 9.0-16.4%) of cases in the overall population of fetuses with PLSVC and in 7.0% (95% CI, 2.7-13.0%) of isolated cases. Additional ICAs and ECAs were detected only after birth and missed at ultrasound in 2.4% (95% CI, 0.5-5.8%) and 6.7% (95% CI, 2.2-13.2%) of cases, respectively. Coarctation of the aorta was associated with isolated PLSVC in 21.3% (95% CI, 13.6-30.3%) of cases. PLSVC is commonly associated with ICAs, ECAs and chromosomal anomalies. Fetuses with isolated PLSVC should be followed up throughout pregnancy in order to rule out coarctation of the aorta. As most of the data in this review were derived from

  16. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... ultrasound images are captured in real-time, they can show the structure and movement of the body's ... Obstetrical Ultrasound page for more information . Ultrasound examinations can help diagnose symptoms experienced by women such as: ...

  17. Prenatal diagnosis of hemimegalencephaly.

    Science.gov (United States)

    Lang, Shih-Shan; Goldberg, Ethan; Zarnow, Deborah; Johnson, Mark P; Storm, Phillip B; Heuer, Gregory G

    2014-01-01

    In recent literature, there have been case reports of prenatal diagnosis of hemimegalencephaly, an extremely rare entity characterized by enlargement of all or portions of 1 cerebral hemisphere and intractable seizures. A unique case is presented of hemimegalencephaly of a fetus diagnosed in utero. A 27-year-old woman presented at 32 weeks' gestation for fetal magnetic resonance imaging after an abnormal fetal ultrasound. Fetal magnetic resonance imaging showed hemimegalencephaly of the left cerebral hemisphere with abnormal gyration. The patient was born via cesarean section at 39 weeks' gestation. He had continuous infantile spasms and partial-onset seizures starting on day 1 of life, and electroencephalography showed burst suppression. The patient's seizures were initially managed with antiepileptics, prednisolone, and a ketogenic diet; however, he was hospitalized multiple times because of status epilepticus. At 6 months of age, he underwent a successful anatomic left hemispherectomy. In utero diagnosis of complex developmental brain anomalies allows a multidisciplinary approach to provide optimal prenatal patient treatment and parental counseling. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Correlation study of prenatal ultrasound screening system and fetal chromosomal abnormalities%产前系统超声筛查与胎儿染色体异常的相关性研究

    Institute of Scientific and Technical Information of China (English)

    刘智霞

    2015-01-01

    Objective To investigate the correlation of prenatal ultrasound screening system with fetal chromosom-al abnormalities.Methods From July 2013 to July 2014, 115 cases of prenatal ultrasound screening system abnormal sit-uation were selected , invasive prenatal testing was given and chromosome karyotype was analyzed , correlation of ultrasound abnormalities with chromosomal abnormalities were analyzed .Results One hundred and fifteen cases of maternal abnormal ultrasound underwent amniocentesis or umbilical vein by karyotype analysis , chromosomal abnormalities in 28 cases were detecleal among 81 cases of severe abnormal maternal ultrasound , 4 cases of minor cases did not appear abnormal chromo-somal abnormalities, there were significant differences in the incidence of abnormalities of the two groups (P<0.05), the incidence of chromosomal abnormalities reached 45.95% when the fetal congenital heart disease with cardiac malforma-tions.Conclusions Prenatal ultrasound screening system can be found most of the abnormal development of the fetus , which provides a reliable basis for further invasive diagnostic line .%目的 探讨产前系统超声筛查与胎儿染色体异常的相关性. 方法 选择2013年7月至2014年7月行产前系统超声筛查出现异常情况的中晚孕期产妇115例,经产妇同意与产前咨询后,予以侵入性的产前检查并分析染色体的核型,分析超声异常表现与染色体异常的相关性. 结果 115例超声检查出现异常的产妇均接受脐静脉或羊水穿刺,经染色体核型的分析,81例超声检查严重异常产妇检出染色体异常28例,4例微小异常病例未出现染色体异常,两组染色体异常发病率比较差异有统计学意义(P<0.05),当胎儿先心病合并心外畸形时染色体异常发病率达到45.95%. 结论 产前系统超声筛查能发现大部分的胎儿异常发育,从而为进一步行侵入性诊断提供可靠依据.

  19. Prenatal diagnosis of 47,XXX.

    Science.gov (United States)

    Khoury-Collado, Fady; Wehbeh, Ammar N; Fisher, Allan J; Bombard, Allan T; Weiner, Zeev

    2005-05-01

    We report 2 cases of 47,XXX that were diagnosed prenatally and were screened positive for trisomy 21 by biochemical and ultrasound markers. These cases underline the importance of discussing the sex chromosome abnormalities during the genetic counseling after an abnormal triple screen test or ultrasound examination.

  20. Prenatal ultrasound diagnosis of lateral ventriculomegaly and abnormalities%产前超声诊断胎儿侧脑室增宽及合并畸形

    Institute of Scientific and Technical Information of China (English)

    袁美贞; 严英榴; 任芸芸; 周毓青; 孙莉

    2011-01-01

    目的 探讨产前超声诊断胎儿侧脑室增宽合并胎儿结构畸形的临床价值.方法 回顾性分析2006年1月一2010年6月来我院检查的27 027名孕妇中超声检出的293胎侧脑室增宽胎儿的超声检查资料.结果 293胎侧脑室增宽胎儿中,未合并胎儿结构畸形232胎(232/293,79.18%);合并胎儿结构畸形61胎(61/293,20.82%),其中最常见的合并畸形为神经系统畸形(42/61,68.85%),其次为心血管系统畸形(21/61,34.43%).结论 产前超声检查发现胎儿侧脑室增宽时,应仔细检查胎儿各系统结构,了解有无合并胎儿结构畸形,尤其是神经系统和心血管系统.对于仪有侧脑室轻度增宽而无明显结构畸形的胎儿·在妊娠后期也应加强随访.%Objective To investigate the value of ultrasound in diagnosing fetal lateral ventriculomegaly (VM) and structural malformations. Methods From Jan 2006 to Jun 2010, 27 027 pregnant women underwent ultrasound, and 293 fetuses with lateral VM were detected. Results Among 293 lateral VM fetuses, lateral VM occurred as an isolated abnormality in 232 fetuses (232/293, 79.18%), combining with other associated structural malformations in 61 fetuses (61/293, 20. 82%), common abnormalities mainly included nerve system anomalies in 42 (42/61, 68. 85%) and cardiovascular system anomalies in 21 (21/61, 34. 43%) fetus. Conclusion Once lateral VM was detected with ultrasound, it is suggested to check fetal structure carefully, especially nerve system and cardiovascular malformation. Moreover, it is necessary to strength prenatal follow-up survey for mild lateral VM fetus without structural malformations.

  1. The role of prenatal ultrasound and MRI in diagnosis of fetal agenesis of corpus callosum%胎儿胼胝体缺如产前超声及磁共振诊断的应用分析

    Institute of Scientific and Technical Information of China (English)

    兰为顺; 杨小红; 夏薇; 刘芳; 余旭东; 袁先宏; 李琳; 苏永学; 杨文忠; 陈欣林

    2015-01-01

    目的分析胎儿胼胝体缺如的产前超声及磁共振诊断价值。方法对2013年7月至2014年12月湖北省妇幼保健院产前超声筛查怀疑胼胝体缺如的67例胎儿于超声检查后3 d内行颅脑磁共振检查,与引产或出生后检查结果对照,对产前超声及磁共振检查结果进行分析。结果产前超声怀疑胼胝体缺如的67例胎儿磁共振检查后均证实为胼胝体缺如,其中胼胝体完全缺如58例,胼胝体部分缺如9例(均为胼胝体体部和压部缺如)。胎儿胼胝体缺如在磁共振正中矢状位图像上表现为胼胝体完全或部分缺如,脑回呈放射状排列;在横轴位和冠状位图像上表现为侧脑室轻至中度扩张,形态失常。结论磁共振对胎儿胼胝体缺如有较高的诊断价值,可作为产前超声的补充和验证方法,在产前超声检查怀疑胎儿胼胝体异常时,应行胎儿磁共振检查明确诊断。超声与磁共振联合筛查,是胎儿中枢神经系统畸形产前检查中重要的影像学诊断方法。%Objective To discuss the value of prenatal ultrasound and MRI in diagnosis of fetal agenesis of corpus callosum (ACC). Methods Sixty-seven fetuses from Hubei Maternal and Children's Hospital performed fetal MRI from July 2013 to December 2014 were included in this study. All fetuses (67 cases) with suspected ACC were studied with a 1.5T MR unit within 3 days after ultrasound examination. Prenatal ultrasound and MRI findings were studied. Results All the 67 ACCs previously suspected on ultrasound were confirmed by MRI. Among the 67 ACCs, 58 cases were complete ACC and 9 cases were partial ACC. Corpus callosum body and/or splenium absence was found in all 9 partial ACC cases. In all cases, on MRI, corpus callosum complete or partial absence was showed on the median sagittal images, and mild to moderate ventriculomegaly and abnormal morphology in lateral ventricle was shown on the axial or coronary images

  2. Prenatal diagnosis of interruption of the inferior vena cava by ultrasound%下腔静脉离断产前超声诊断

    Institute of Scientific and Technical Information of China (English)

    姚远; 李胜利; 陈秀兰; 文华轩; 廖玉媚; 肖志莲

    2012-01-01

    semiazygos vein in transthoracoabdominal coronal view and only the above liver portion of inferior vena cava could be found in the longitudinal section of right atria view. Conclusions Interruption of the inferior vena cava is always complicated with cardiac and outside cardiac malformation atria view. And the abnormalities can be identified in the following ultrasound views: four-chamber view, upper abdominal view, transthoracoabdominal coronal view and longitudinal section of right atria view. Identification of these ultrasound characteristics can improve the prenatal detection rate of interruption of the inferior vena cava.

  3. Subsequent Fertility of Goats with Prenatal Mortality Diagnosed by Ultrasound and Treated by PGF2α and Oxytetracycline

    Science.gov (United States)

    Aban, A. S.; Badawi, M. E.; Almubarak, A. M.

    2017-01-01

    Thirteen Saanen and Saanen crossbred female goats, between the ages of 6 months and 7, years were presented to the clinic, College of Veterinary Medicine, Sudan University of Science and Technology, for sonographic pregnancy diagnosis. Transabdominal ultrasound was performed using 3.5 MHz probe which revealed non-viable fetuses as judged by absence of heart beats and movements. Twelve goats were given single i/m injection of PGF2α analogue and 5% oxytetracycline. Ten goats responded to the treatment and six of them became pregnant and gave birth within the normal gestational period. One goat was diagnosed as non-pregnant, one goat developed hydrometra, and the subsequent fertility of two goats was unknown. Two full-term goats did not respond to treatment. Another dose of PGF2α was administered to them and again they did not respond. Manual attempts were done to deliver the full-term goat with dilated cervix and they were unsuccessful. Cesarean section and hysterectomy were then performed for the three full-term goats with unfavorable outcome. It can be concluded that ultrasound is a rapid, reliable, and nonhazardous procedure for the diagnosis of fetal mortality in goats and PGF2α treatment in conjunction with oxytetracycline is an efficient treatment. PMID:28116216

  4. 产前超声在双胎妊娠中胎儿心脏复杂畸形中的应用%Application of Prenatal Ultrasound in Fetal Cardiac Complex Malformation in Twin Pregnancy

    Institute of Scientific and Technical Information of China (English)

    丁凤霞

    2016-01-01

    目的:分析产前超声在双胎妊娠中胎儿心脏复杂畸形中的临床价值。方法:回顾性分析我院于2012年1月~2015年1月期间经产前超声检查的双胎妊娠孕妇16例,至少有1例孕妇合并心脏复杂畸形,对孕妇产前、产后超声结果进行总结,并分析其产前漏诊原因。结果:经产后超声检查,证实本组16例孕妇均合并心脏复杂畸形的双胎,其中有11例为单绒毛膜囊双胎,有5例为双绒毛膜囊双胎。有14例孕妇经产前超声检查明确诊断,且由产后随访检查证实;有1例A型主动脉弓离断,其心脏复杂畸形多与心外畸形共存;有1例右室双出口出现漏诊,经产前诊断为室间隔缺损。结论:通过产前超声筛查,可有效诊断单绒毛膜囊双胎合并心脏复杂畸形的发生率明显高于双绒毛膜囊双胎,其具有良好的临床价值。%Objective: to analyze the clinical value of prenatal ultrasound in fetal cardiac complex malformation in twin pregnancy.Methods:a retrospective analysis of our hospital in 2012 January 2015 period in January by prenatal ultrasound examination of twin pregnancy in 16 cases, at least 1 cases of pregnant women with complex heart malformation, the prenatal and postnatal ultrasound results are summarized and and analysis of prenatal reasons for misdiagnosis.Results: multiparous after ultrasound examination, confirmed that this group of 16 cases of pregnant women were associated with cardiac malformation complex twins, of which 11 cases for sac properties of monochorionic twins, 5 cases of cystic nature of dichorionic twin pregnancy. With 14 cases pregnant women by prenatal ultrasound diagnosis and confirmed by postnatal follow-up examination;1 case of type A aortic arch interruption, the complex heart malformation with extracardiac malformations coexist; 1 case of right ventricular double outlet of missed diagnosis and prenatal diagnosis for ventricular septal defect

  5. Pilot Study to Show the Feasibility of High-Resolution Sagittal Ultrasound Imaging of the Temporomandibular Joint.

    Science.gov (United States)

    Katzberg, Richard W; Conway, William F; Ackerman, Susan J; Gonzales, Theresa S; Kheyfits, Valeriy; Cronan, Michael S

    2017-06-01

    To show the feasibility of acquiring high-resolution sagittal ultrasound (US) images of the temporomandibular joint (TMJ). We used commercially available US probes to assess the TMJ via a transoral soft tissue window to acquire sagittal images. Magnetic resonance imaging and clinical correlation were compared with the US findings by the consensus assessment of 2 of the senior investigators. The sample was composed of 10 TMJs (6 participants) with an age range of 34 to 71 years and a male-female ratio of 3:1. The condyle and subcondylar surface were visible in 10 of 10 joints (100%), the disc in 7 of 10 joints (70%), and the pterygoid muscles in 6 of 10 joints (60%). In the 5 joints with magnetic resonance correlation, disc position and configuration were confirmed in all cases. We show the first sagittal transoral sonograms of the TMJ disc and associated joint components. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  6. The Value of Down Syndrome Screening Combined with Four Dimensional Colour Doppler Ultrasound in Prenatal Diagnosis%唐氏筛查联合四维彩超在产前诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    邓玲; 汤辉; 黎兴盛; 郭平

    2015-01-01

    Objective:To explore the application value of Down syndrome screening combined with four dimensional colour doppler ultrasound in prenatal diagnosis.Method:From January 2011 to December 2014, 2578 cases of pregnant women for 14 to 24 weeks were selected in maternity clinics in our hospital,they were examined by Down syndrome screening and four dimensional colour doppler ultrasound.Result:2578 cases of pregnant women were all examined by Down syndrome screening and four dimensional colour doppler ultrasound. Positive rate of Down syndrome screening was 4.84%,positive rate of was four dimensional colour doppler ultrasound was 0.96%,positive rate of combined examination was 5.81%, positive rate between Down syndrome screening and combined examination had no statistical significance (P>0.05),positive rate between four dimensional colour doppler ultrasound and combined examination had statistical significance(P0.05),与四维彩超筛查比较差异有统计学意义(P<0.05).结论:唐氏筛查联合四维彩超在产前筛查中的意义重大,可提高唐氏儿和其他染色体病儿及各种畸形的诊断率,及时做出判断是否终止妊娠,为家庭和社会减轻了沉重的负担.

  7. Application progress of prenatal ultrasound in twin-twin transfusion syndrome%产前超声检查在双胎输血综合征中的应用进展

    Institute of Scientific and Technical Information of China (English)

    蒋瑜; 杨太珠

    2012-01-01

    Twin-twin transfusion syndrome (TITS) is a potentially seriouscomplication of monochorionic twin pregnancies, with high incidence and poor prognosis. As the main means of prenatal examination, ultrasonography is useful for early detection, diagnosis and treatment of TITS and it can improves the quality of life of perinatal infante- This article reviews the application progress of prenatal ultrasound in TITS.%双胎输血综合症(TTTS)是单绒毛膜双胎的一种严重并发症,其发病率较高,预后较差.超声作为产前检查的主要手段,能够早期发现、诊断,并及时治疗,从而提高围产儿的生存质量,本文就产前超声检查在TTTS的应用进展做一综述.

  8. Clinical application of standard prenatal ultrasound in screening the fetal malformation%规范化产前超声筛查胎儿异常的临床应用

    Institute of Scientific and Technical Information of China (English)

    何宇; 魏振彤; 费君伟; 冯丽华; 于晓伟

    2011-01-01

    Objective: To evaluate the clinical value of standardization prenatal ultrasound in screening the fetal malformation. Methods; Totally 2 175 pregnant women were inspected by standardization prenatal ultrasound examination in our hospital during May 2006 to March 2011. Fetal standard ultrasound cuts were saved . The content and form of ultrasound report were standard. These cases were followed to pregnancy ending. Results; 201 cases of fetal structural abnormalities (9. 23% ) were diagnosed by standardization ultrasound examination. 4 cases of fetal attachments abnormalities were diagnosed. The central nervous system malformation ranked first, uro-genital system malformation, fetal edema syndrome, digestive system malformation, cardiac abnormalities were followed Conclusion; The detecting rate of ultrasound screening in standardization prenatal diagnosis is much higher, and it has significant clinical utilities in diagnosing fetal malformation.%目的:评估规范化产前超声筛查胎儿异常的临床应用价值.方法:2006年5月~2011年3月进行规范化超声检查孕妇2 175例,规范化保存胎儿标准切面图片,规范化超声报告的内容和格式并追踪妊娠结局.结果:规范化超声检查胎儿2 175例,发现和产后证实胎儿异常201例(9.23%),其中胎儿附属物异常4例.胎儿畸形类型中中枢神经系统畸形占首位,其次为泌尿系统畸形、胎儿水肿综合征、消化系统畸形、心血管系统畸形.结论:规范化产前超声诊断出生缺陷检出率较高,对于诊断胎儿结构异常有着非常重要的临床价值.

  9. 胎儿肢体畸形的产前超声诊断分析%Prenatal ultrasound diagnosis and analysis of fetal limb deformities

    Institute of Scientific and Technical Information of China (English)

    张晓慧; 肖利军; 邓旦; 梁燕; 廖明松; 罗丹

    2014-01-01

    目的:探讨胎儿肢体畸形超声声像图特征及方法学特点。方法回顾性分析2010年5月至2012年5月在成都军区总医院接受系统性超声检查的6336例孕妇,使用连续顺序追踪超声法(SCSA )检测胎儿上下肢长骨,观察手足时加用弧形扫查法,动态观察胎儿肢体的形态、结构、姿势及运动等情况。系统检查完成后对可疑或畸形部位进行三维成像作为补充,对胎儿肢体畸形的产前超声诊断结果进行分析。结果6336例孕妇经引产或出生后证实的胎儿肢体畸形20例,产前超声检出18例,分别为四肢短小畸形5例,致死性侏儒3例,海豹肢畸形1例,双侧桡骨缺失1例,一侧手缺失1例,双下肢小腿缺失1例,多指(趾)2例,足内翻3例,重叠指1例;2例漏诊分别为多指及重叠指。结论末端指趾数目及手足姿势异常易漏诊,是检查的难点和重点。%Objective To explore the ultrasonographic characteristics and methodology characteristics of fetal limb deformities . Methods A retrospective analysis was made on 6 336 pregnant women accepting systematic prenatal ultrasonography during the period of May 2010 to May 2012 in the General Hospital of Chengdu Military Region .The long bones of the upper and lower limbs were scanned by using the systematic continuous sequence approach (SCSA) and by adding the arc rotaryprocess for observing the hands and feet ,fetal limbs morphology ,structure ,posture and movement ,etc .were dynamically observed .The suspected position or fetal limb deformities were examined with three-dimensional(3D) ultrasonography as the supplementary .The prenatal ultrasound examination results of fetal limb deformities were analyzed .Results Among 6 336 pregnant women ,20 cases of fetal limb deformi-ties were confirmed by induced labor or after birth ,18 cases were diagnosed by the prenatal ultrsound ,including 5 cases of short limbs deformity ,3 cases of fatal

  10. 阴茎阴囊转位产前超声诊断并文献回顾%Prenatal diagnosis of penoscrotal transposition by ultrasound and review of literature

    Institute of Scientific and Technical Information of China (English)

    毕静茹; 王银; 李胜利; 文华轩

    2011-01-01

    Objective To assess the prenatal features of penoscrotal transposition by ultrasound. Methods The prenatal ultrasonogram of two fetuses, which were diagnosed as penoscrotal transposition, was retrospectively reviewed. The prenatal characteristics were summarized by ultrasound, and compared with those of autopsy. Literatures referring to the prenatal diagnosis of such abnormality were reviewed.Results The ' tulip sign ' was characteristic prenatal ultrasound imaging of penoscrotal transposition with a bifid scrotum and hypospadias, which was partially or completely formed by the malpositioned scrotum anterior to the penis and the ventrally bent penis was located between the two scrotal folds. The color Doppler imaging of the micturating fetus may be helpful for display of dystopia of meatus. Conclusion Antenatal ultrasonography is an effective and feasible way to diagnose penoscrotal transposition.Penoscrotal transposition should be differentiated in case of ambiguous genitalia.%目的 探讨阴茎阴囊转位的产前超声声像图特征.方法 总结2例在胎儿系统超声检查中诊断为部分性阴茎阴囊转位胎儿的产前超声声像图表现,与引产后胎儿的生殖器形态特征进行对比,并对阴茎阴囊转位胎儿产前诊断的相关文献进行回顾分析.结果 阴茎阴囊转位胎儿产前超声诊断的声像图典型表现为"郁金香"征,阴茎部分或完全位于阴囊下方,阴茎常表现为短小,合并尿道下裂时可根据胎儿排尿时CDFI检测确定尿道口的位置.结论 产前超声检查是诊断胎儿阴茎阴囊转位有效可行的检测手段.在胎儿性别难以辨认时,应注意识别是否为阴茎阴囊转位畸形.

  11. The Dianosis Value of Prenatal Ultrasound Screening Combined with Prenatal Maternal Serum Markers Detecting in Trimester Pregnancy for the 21 - trisomy Syndrome%中孕B超产前检查联合母血清标记物对21-三体综合征的临床诊断价值

    Institute of Scientific and Technical Information of China (English)

    李洁; 陈大雁; 胡桂朗; 荆志敏

    2011-01-01

    Objective: To explore the feasibility, effectiveness and necessity of the prenatal ultrasound screenings,combined with the content inspection of the mothers' prenatal maternal serum markers:in trimester pregnancy Alpha-fetoprotein ( AFP), free estriol ( uE3 ), total serum β human chorionic gonadotropin ( hCG) in the 21 -trisomy syndrome. Method: We summarized the detection rate of the 21 -trisomy syndrome by prenatal ultrasound screening and the prenatal maternal serum markers. Result: The detection rate in terms of the positive signs of the prenatal ultrasound screening in trimester pregnancy combined with the prenatal maternal serum markers in the 21-trisomy syndrome diagnosis was 80%-90%. Conclusion:The prenatal ultrasound screening in trimester pregnancy combined with prenatal maternal serum markers in the 21trisomy syndrome diagnosis is a non-invasive checking method, not only can reduce the abnormal or deformed children are born, can also reduce the invasive inspection; It has the davantage of clinically simple,application and testing of a wide range of safe and effective, cost-effective, with higher screening detection rate, and reduce the intrusion caused by the check normal fetal abortion rate.%目的:探讨中孕B超产前检查出现阳性征,及联合母体血清标记物指标:甲胎蛋白(AFP)、游离雌三醇(uE3)、血清总β绒毛膜促性腺激素(hCG)的含量检查对21-三体综合征的产前筛查和诊断的可行性、有效性和必要性.方法:回顾了中孕B超产前检查联合母血清标记物对21-三体综合征检出率.结果:中孕B超产前检查的阳性征,联合母体血清标记物检查指标对21三体综合征检出率高达80%-90%.结论:中孕超声检查,及联合母血清标记物进行唐氏综合征胎儿筛查是一种非侵入性的检查方法,不但可以减少异常或畸型儿童出生,提高人口素质,也可以减少侵入性的检查;且具有临床操作简便、应用范围和检验范围面广

  12. Prenatal ultrasound in diagnosis of fetal facial profile and associated genetic disorders%产前超声评估胎儿颜面轮廓及相关遗传学疾病

    Institute of Scientific and Technical Information of China (English)

    欧阳云淑; 孟华; 姜玉新; 戴晴; 张一休; 钟定荣; 赵大春; 刘欣燕

    2012-01-01

    目的 探讨产前超声评估胎儿颜面轮廓的可行性及对胎儿遗传学疾病的提示价值.方法 应用产前二维及三维超声观察20胎胎儿的颜面正中矢状面,评估颜面轮廓异常,并与染色体分析结果进行对照.结果 发现9胎21-三体、4胎18-三体、1胎13-三体和1胎4p-,5胎染色体正常.20胎中,鼻骨缺失或发育不良共8胎(6胎21-三体,2胎染色体正常);鼻前组织增厚9胎(8胎21-三体,1胎4p-);小下颌8胎(4胎18-三体,1胎21-三体,1胎13-三体,1胎4p-及1胎染色体正常);颜面扁平5胎(2胎21-三体,2胎Larsen综合征,1胎染色体正常);上颌前突2胎(1胎13-三体,1胎18-三体).结论 颜面正中矢状面有助于提示胎儿染色体异常及遗传综合征,其中鼻骨及下颌评估对21-三体及18-三体的提示意义明确,可作为中孕期筛查的常规内容.%Objective evaluate fetal facial profile with prenatal ultrasound, and to determine its diagnostic value for genetic disorders. Methods Sonographic findings of 20 fetuses were reviewed. Facial midsagittal plane was carefully evaluated with two-dimensional and three-dimensional ultrasound, and all fetuses underwent chromosomal analysis. Results There were 9 fetuses of trisomy 21, 4 of trisomy 18, 1 of trisomy 13 and 1 of 4p- , the remaining fetuses had normal kary-otype. Eight fetuses had absent or hypoplastic nasal bones, including 6 of trisomy 21 and 2 of normal karyotype. Nine fetuses showed increasing prenasal thickness, including 8 of trisomy 21 and 1 of 4p-. Eight fetuses had micrognathia, including 4 of trisomy 18, 1 of trisomy 21, 1 of trisomy 13, 1 of 4p- and 1 of normal karyotype. Five fetuses showed flat face, two of which were trisomy 21, another two were Larsen syndrome, and the remaining 1 showed normal karyotype. Two fetuses had premaxillary protrusion, proved to be trisomy 13 and trisomy 18. Conclusion Facial midsagittal plane may contribute to prenatal detection of genetic disorders and need

  13. 胎儿颅内出血超声联合磁共振成像诊断与妊娠结局%The prenatal ultrasound and magnatic resonance imaging characteristics of fetal intracranial hemorrhage

    Institute of Scientific and Technical Information of China (English)

    韩瑾; 戴常平; 廖灿; 曾斯慧; 甄理; 杨昕; 潘敏; 刘鸿圣; 李东至; 白洁; 虞翌旻

    2015-01-01

    Objective To investigate the diagnostic value of prenatal ultrasonography and magnatic resonance imaging in the fetal intracranial hemorrhage. Methods The 20 antenatal diagnosed ICH cases was collected from 31 200 prenatal diagnosis units in Guangzhou Women and Children′s Medical Center from July 2012 to June 2014. Maternal characteristics, ultrasound, and magnetic resonance imaging findings, clinical course, and postnatal outcome were reviewed. Results Twenty consecutive cases of fetal ICH were evaluated. All cases were diagnosed at mid or third trimester. Transabdominal ultrasound showed 9 cases of hyper echoic lesions in the lateral ventricle, 2 cases of hypoechonic lesions, 2 cases of irregular mixed echo in the parenchyma, 1 case of hyperechoic cerebellar hemisphere with infarction, and 1 case of abnormal choroid plexus. Seventeen cases were associated with ventriculomegaly, brain compression or brain midline displacement. MRI showed the nodular, patchy or linear low signal on T2WI and high signal on T1WI. Some cases were combined with cortex lesions or abnormal parenchyma. ICH was complicated with other structural abnormalities:1 case of cleft palate, 2 cases of spinal deformity and 3 cases of other cerebral cortical malformations. Prenatal diagnosis results were:2 cases diagnosed as positive cytomegalovirus infection and no chromosome abnormalities found in all cases. The follow up results were:1 case was lost, 16 cases were terminated after prenatal diagnosis. Among the 3 survival cases, 1 case has the neurological complication and the other two were normal till now. Conclusions Fetal intracranial hemorrhage has some image features on ultrasound and magnetic resonance. Ultrasound showed hyper echoic lesions with ventriculomegaly. MRI showed the nodular, patchy or linear low signal on T2WI and high signal on T1WI. MRI may contribute to the accuracy of diagnosis, particularly in bleeding site. The regular ultrasonic monitoring is helpful to improve the

  14. 产前超声检查在胎盘植入诊断中的临床价值%The Clinical Value of Prenatal Ultrasound in the Diagnosis of Placenta Increta

    Institute of Scientific and Technical Information of China (English)

    王薇薇

    2015-01-01

    目的:分析胎盘植入的超声影像特点,探讨产前超声检查对胎盘植入的诊断价值。方法选择我院在2011年12月~2014年8月收治的51例胎盘植入患者作为研究对象,回顾性分析产前超声检查的检出情况,并总结超声图像特点。结果产前超声检查检出率为37.25%,检出患者的超声图像特点为胎盘内漩涡形成、未见胎盘后间隙消失、子宫肌层局部菲薄以及胎盘异常增厚。结论产前超声检查有利于胎盘植入的早期诊断,结合超声声像图特征,对胎盘植入的产前诊断具有重要意义。%Objective To analyze the characteristics of ultrasonography for placenta increta, explore the value of prenatal ultrasonography in diagnosis of placenta increta. Methods From December 2011 to August 2014, 51 cases with placenta increta in my hospital were selected as the research object, the ultrasonic image data were analyzed retrospectively, and summarized the characteristics of ultrasound image. Results The rate of prenatal ultrasound detection for placenta increta was 37.25%;The ultrasonic image characteristics for placenta increta was the vortex formation in the placenta, no disappearing placental post-clearance, local thinning muscular layer of uterin, and abnormal thickening placenta. Conclusion Prenatal ultrasound is beneficial to early diagnosis of placenta increta, and ultrasonographic features has important signiifcance in prenatal diagnosis of placenta increta.

  15. 产前系统超声筛查与胎儿染色体异常的关系%The Correlation for Prenatal Ultrasound Screening of Fetal Malformations and Fetal Chromosomal Abnormality

    Institute of Scientific and Technical Information of China (English)

    戴晨燕; 茹彤; 顾燕; 杨燕; 杨丽娟; 徐燕

    2011-01-01

    目的:探讨产前系统超声筛查中晚孕期胎儿结构异常对指导进行侵入性产前诊断的价值.方法:2008年1月至2009年6月对我院中晚孕期孕妇行系统超声及超声心动图筛查,发现胎儿异常时经产前咨询及孕妇知情同意后,进行侵入性产前检查即羊水或脐静脉穿刺,进行染色体核型分析,分析各种类型的超声异常表现与染色体异常发病风险的关系.结果:共有105例超声检查发现胎儿异常的孕妇接受了羊水或脐静脉穿刺行胎儿染色体核型分析,77例超声发现严重异常的病例中检出26例染色体异常(26/77),严重异常组与微小异常组之间染色体异常发病的差异有高度统计学意义(χ2=12.566,P<0.001),尤其是胎儿先天性心脏病合并心外畸形时,染色体异常发病率高达55%(11/20).结论:产前系统超声及超声心动图筛查可以发现大多数的胎儿发育异常,特别是胎儿先天性心脏病,可以为进一步进行侵入性产前诊断提供重要依据.%Objective:To assess the effectiveness of systematic ultrasound in second or third trimester to detect fetal malformations for instructing the necesity of further invasive prenatal diagnosis.Methods:This retrospective study included pregnancy women from January 2008 to June 2009 in the Affiliated Drum Tower hospital of Nanjing University Medical College.Those women had systematic ultrasound and echocardiogram examination within the second or third trimester of pregnancy.When fetal malformations were found, the invasive prenatal diagnosis (puncture of amniotic fluid or umbilical vein) was suggested to check the chromosomal abnormalities and analyze their relationship.Results:105 pregnant women who were found fetal abnormalities were recruited and had the invasive prenatal diagnosis, 26 cases of chromosomal abnormalities were found in 77 obvious ultrasound abnormalities.There was significant difference in chromosomal abnormalities between obvious and

  16. Real -time 3D ultrasound prenatal diagnosisof the clinical significance of fetal typical facial cleft deformity%实时三维超声产前诊断胎儿典型面裂畸形的临床意义

    Institute of Scientific and Technical Information of China (English)

    龚海英; 李琴; 艾明义

    2012-01-01

    Objective; To determine the value of Real - time 3D ultrasound prenatal diagnosis of the clinical significance of fetal for typical facial cleft deformity Improving the diagnosticaccuracy of fetal cleft lipand/or palate cleft. Methods; Application of real - time three dimensional echocardiography prenatal fetal normal fetal cleft lip and palate cleft lip and palate parts of two - dimension control. Result; 10 cases of normal fetal lip display rates 100% , On alveolar show 100% , and palate, 70% (7/10) . 10 cases of fetal cleft lip and palate cleft lip includes 7 simple, merge hard on 1 case of cleft lip and palate and 1 cleft lip patients with cleft of soft palate. Real - time 3D diagnostic all 7 example simple cleft palates, diagnostic rate 100% . Diagnosis of unilateral cleft lip with cleft palate in 1 case. There are 1 case of unilateral cleft lip with cleft palate only diagnosis and missed diagnosis of cleft lip and cleft palate, diagnosed in 70% ( Seven - tenths). 1 cases of cleft lip with cleft of soft palate only soft diagnosis and missed diagnosis of cleft lip and cleft palate. Conclusions: Real - time three dimensional echocardiography prenatal diagnosis of fetal cleft lip, especially hard and alveolar process cleft lip with cleft palate diagnostic has a large value, but on the fetus are not merged alveolar cleft of the soft palate and some of the hard palate to make diagnosis and still has a great deal of difficulty.%目的 探讨实时三维超声产前诊断胎儿面裂畸形的临床意义,寻求提高胎儿唇腭裂诊断准确性的有效方法.方法 应用实时三维超声产前对面裂畸形;唇腭裂胎儿和正常胎儿唇腭部位的二维进行对照.结果 10例正常胎儿面部显示率100%,上牙槽突显示率100%,硬腭显示率70% (7/ 10).10例唇腭裂胎儿包括7例单纯唇裂,2例上唇裂合并硬腭裂和1例唇裂合并软腭裂.实时三维诊断了所有7例单纯唇裂,诊断率100%;诊

  17. The value of prenatal ultrasound diagnosis of fetal edema%产前超声诊断胎儿水肿的价值

    Institute of Scientific and Technical Information of China (English)

    董慧琴; 王晓炜; 吴争勇

    2015-01-01

    目的:探讨胎儿水肿的病因及超声声像图特征,提高对胎儿水肿的认识.方法:回顾我院2009年1月至2013年1月间行产前超声检查的32047例孕妇,共检出27例胎儿水肿,结合病因及超声声像图特征作相关分析.结果:孕10-13+6周胎儿水肿3例,孕14-27+6周胎儿水肿17例,孕28-38周胎儿水肿7例.超声图像的主要特征为胎儿皮肤水肿,颈部淋巴水囊瘤,腹围/头围比值增大,胸腔积液,腹腔积液,心包积液,心动过缓,心动过速,羊水过多,羊水过少,脐动脉S/D增高等.母婴血型不合1例,宫内感染1例.24例行染色体检查,结果为Turner综合征9例,21-三体7例,染色体正常8例. 1例病因不明.结论:超声对胎儿水肿诊断准确,为妊娠期筛查提供重要依据.%Objective:To investigate the etiology of fetal hydrops and ultrasonogr aphic features, to improve the understanding of fetal hydrops.Methods:A review of 32047 cases of pregnant women in our hospital from 2009 January to 2013 January in the prenatal ultrasound examination, there were 27 cases of fetal hydrops, combined with the cause and the sonographic features of correlation analysis.Results:In 3 cases of pregnancy 10-13+6 weeks of fetal hydrops fetal edema, 17 cases with 14-27+6 weeks, 28-38 gestational weeks of fetal edema in 7 cases. The main characteristics of ultrasound images of the fetal skin edema, cervical lymphatic hygroma, abdominal circumference / head circumference ratio increases, ascites, pleural effusion, pericardial effusion, slow heartbeat, heartbeat tachycardia, polyhydramnios, oligohydramnios, umbilical artery S/D higher etc. Maternal fetal blood group incompatibility in 1 cases, 1 cases of intrauterine infection. 24 routine chromosome examination, the results for 9 cases of Turner syndrome, trisomy of chromosome 21- in 7 cases, normal in 8 cases. 1 cases of unknown etiology.Conclusion:ultrasonography in the diagnosis of fetal hydrops is accurate,provide an important basis

  18. Clinical value of prenatal ultrasound diagnosis of fetal central nervous system abnormalities%产前超声诊断胎儿神经系统畸形的临床价值

    Institute of Scientific and Technical Information of China (English)

    韩磊; 沈亚梅; 彭建美; 管湘平; 王珍芳; 邹荣莉

    2016-01-01

    Objective To evaluate the clinical value of prenatal routine ultrasound examination in screening of fetal central nervous system abnormalities.Methods Ultrasound imaging features of 27 cases of abnormalities in central nervous system confirmed by autopsy or follow-up were analyzed retrospectively.Results Among these cases, there were 11 cases of spine bifida and meningomyelocele, 3 cases of Dandy-Walker syndrome ( DWS) , 3 cases of cephalocele, 3 cases of hydrocephalus, 1 case of anencephaly, 2 cases of holoprosencephaly, 2 cases of agenesis of corpus callosum, 1 cases of choroid plexus cysts, and 1 case of arachnoid cyst.The accuracy, misdiagnosis rate and missed diagnosis rate of prenatal ultrasound examination was 88.90%, 7.40%and 7.40%, respectively.Conclusion Prenatal ultrasound examination has high diagnostic accuracy for fetal central nervous system malformations, and it has very important clinical value.%目的 探讨产前常规超声检查在胎儿神经系统畸形筛查方面的临床应用价值.方法 对27例经随访及引产证实的中枢神经系统畸形胎儿进行回顾性分析.结果 27例畸形儿中,其中脊柱裂和脊髓脊膜膨出11例,Dandy-Walker畸形3例,脑脊膜膨出3例,脑积水3例,无脑儿1例,全前脑2例,胼胝体发育不全2例,脉络丛囊肿1例,蛛网膜囊肿1例,产前超声诊断准确率为88.90%,误诊率7.40%,漏诊率7.40%.结论 产前超声检查对胎儿中枢神经系统畸形诊断准确率高,具有十分重要的临床应用价值.

  19. 孕中期复杂性先心病的产前超声筛查%Ultrasound Prenatal Screening for Complex Congenital Heart Disease During the Second Trimester

    Institute of Scientific and Technical Information of China (English)

    孟昕

    2014-01-01

    目的:探讨孕中期超声对复杂性先天性心脏病的筛查作用,提高复杂性先心病的检出率。方法2010年10月至2013年10月期间,我院7295例孕妇于孕21~40周,分别进行对照组(月超检查)和观察组(通过美国G耘灾燥造怎泽燥灶730彩色多普勒超声诊断仪,通过心脏超声筛查的5个标准切面,发现异常心脏节段,再通过彩色多普勒血流信号,观察房室、大动脉血流情况,分析先天性心脏病类型)检查。产前超声诊断结果与本院尸检结果,进行对比分析。结果与对照组相比,观察组复杂性先天性心脏病的临床诊断率明显升高(0.27豫增泽.0.12豫),差异有统计学意义(孕<0.05)。7295例胎儿检出20例复杂性先天性心脏病,其中6例合并心外畸形,14例本院引产,其尸检结果与产前超声诊断结果相一致。结论复杂性先天性心脏病的畸形情况多变,超声分段检查结合彩色多普勒超声的产前超声筛查能够有效提高复杂性先心病的检出率。%Objective To explore the effect of ultrasound prenatal screening for complex congenital heart disease during the second trimester, and to improve the detection rate of complex congenital heart disease. Methods From October 2010 to October 2013, 7 295 pregnant women (pregnant between 21~40 weeks) in our hospital received the B-ultrasonic examination (control group) and color Doppler ultrasonography (GE Voluson 730) examination (observation group) respectively. Color Doppler ultrasonography examination found out abnormal heart segments through screening five standard section of cardiac ultrasound, then by color Doppler flow signals, the atrioventricular and aortic blood flow situation were observed, and the types of congenital heart disease were analyzed. Prenatal ultrasound diagnosis results and hospital autopsy results were taken for comparative analysis. Results Compared with the control group, the clinical diagnosis

  20. Prostate Ultrasound

    Medline Plus

    Full Text Available ... ultrasound images are captured in real-time, they can show the structure and movement of the body's ... Because ultrasound provides real-time images, it also can be used to guide procedures such as needle ...

  1. APPLICATION OF FIRST-MIDTRIMESTER PREGNANCY ULTRASOUND COMBINED WITH INVASIVE PRENATAL DIAGNOSIS IN TWIN PREGNANCY%早中孕期超声联合有创性产前诊断在双胎妊娠中的应用

    Institute of Scientific and Technical Information of China (English)

    胡矩锋; 李炳星; 高丽丽

    2015-01-01

    效降低出生缺陷,在提高人口素质方面有重要的应用价值。%Objective Evaluate application value that ultrasound of first‐midtrimester combined with in‐vasive prenatal diagnosis in linyi city .Methods Research of first‐midtrimester pregnancy ultrasound com‐bined with invasive prenatal diagnosis in twin pregnancy from Octobor 2014 to May 2015 clinic in our hos‐pital during the 11 weeks ago ,statistics of pregnant age ,first trimester ultrasound ,18 to 22 weeks ultra‐sound ,invasive prenatal diagnosis ,prenatal diagnosis ,selective reduction ,etc .summary all the data ,a‐nalysis the application value of first‐midtrimester pregnancy ultrasound combined with invasive prenatal di‐agnosis in twin pregnancy in linyi city .Results Included in the study of a total of 1437 cases of twin preg‐nancy ,anomaly detection ,with pregnancy ultrasound system is 56 cases ,ultrasonic detection of first tri‐mestr abnormalities is 7 cases ,abnormal ultrasonic detection of midtrimester is 49 cases ,invasive prenatal diagnosis to all ultrasonic detection pregnancy ,actually have invasive prenatal diagnosis ,27 cases (48 . 2% ) ,including 3 patients to CVS ,24 cases to amniocentesis .The actual number of prenatal diagnosis of fetal 47 (including twins prenatal diagnosis in 21 cases ,one of the tires to prenatal diagnosis of 5 cases) , diagnosis of five chromosome abnormality ,are one of the twins anomalies (including 1 case no abnormal sonographic findings but prenatal diagnosis) ,including 2 cases of one of twins 21 three body syndrome , chromosome abnormality rate 10 .6% (5/47) .7 cases to selective reduction (5 cases of abnormal chromo‐some abnormality and 2 cases of ultrasonic normal chromosome) ,else choose expectation .Avoided the born of abnormal karyotypes including 2 cases of 47 ,+21 (including ultrasonic no abnormality in 1 case)、2 cases of 47 ,+18 and 1 case of 47 ,+13 ,and 1 case of fetal ascites ,1 cases of tetralogy of fallot

  2. Ultrasound pregnancy

    Science.gov (United States)

    Pregnancy sonogram; Obstetric ultrasonography; Obstetric sonogram; Ultrasound - pregnancy; IUGR - ultrasound; Intrauterine growth - ultrasound; Polyhydramnios - ultrasound; Oligohydramnios - ultrasound; ...

  3. Dyssegmental dysplasia in siblings: Prenatal ultrasonic diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, P.E. Jr.; Hauge, M.; Bang, J.

    1988-01-01

    Two cases of dyssegmental dysplasia (type Silverman-Handmaker) in siblings are presented. The first-born died at the age of 3 months and the second fetus was followed during pregnancy with ultrasound examinations. In the 20th week of gestation marked shortening of the extremities was found; a female infant showing the same radiologic bony malformations as the firstborn was born by cesarean section. These cases support the autosomal recessive inheritance and demonstrate the possibility of prenatal diagnosis in this type of micromelic dwarfism. (orig.)

  4. Sucção digital: observação em ultra-sonografia e em recém-nascidos Evaluation of digital sucking by prenatal ultrasound and in newborns

    Directory of Open Access Journals (Sweden)

    Maria Dânia Holanda Tenório

    2005-12-01

    Full Text Available OBJETIVO: Observar a sucção digital ou da mão em fetos, identificar os fatores relacionados à gravidez de importância para sua manifestação e identificar, após o nascimento do bebê, a permanência da sucção digital. MATERIAIS E MÉTODOS: Dois exames de ultra-sonografias fetais foram realizados em 55 gestantes, nos períodos de 20-24 e 25-32 semanas. Para avaliar os fatores relacionados à gravidez, foram utilizados questionários. Para identificar a permanência da sucção digital, visitas foram realizadas uma semana após o nascimento. RESULTADOS: A sucção digital foi detectada na maioria dos fetos, exceto em 20. Estatisticamente não houve diferenças significativas entre estado de saúde da gestante e o grau de aceitação da gravidez com a manifestação da sucção digital em fetos. O teste Q de Cochran não evidenciou diferenças significativas entre os sinais de sucção digital em fetos e a instalação do hábito em recém-nascidos. CONCLUSÃO: A ultra-sonografia é um método importante para a observação de sinais de sucção digital em fetos. Esses sinais não implicam hábito bucal após o nascimento.OBJECTIVE: To observe digital sucking or hand sucking habits in fetuses using ultrasound, to identify pregnancy related factors that influence its appearance and to evaluate the persistence of digital sucking after delivery. MATERIALS AND METHODS: Two ultrasound examinations were performed in 55 pregnant women with 20-24 and 25-32 weeks of pregnancy. Questionnaires were used to evaluate the factors related to pregnancy. In order to verify the persistence of digital sucking, visits to the newborns were performed one week after delivery. RESULTS: Digital sucking was detected in 35 of the 55 fetus studied. Digital sucking in fetuses was not associated with the health status of the pregnant women and the level of pregnancy acceptance. The Q Cochran test showed no relationship between the observation of digital sucking in the

  5. Prenatal parenting.

    Science.gov (United States)

    Glover, Vivette; Capron, Lauren

    2017-06-01

    Parenting begins before birth. This includes prenatal maternal and paternal bonding with the baby, and biological effects on fetal development. Recent research has confirmed how prenatal maternal stress can alter the development of the fetus and the child, and that this can persist until early adulthood. Children are affected in different ways depending, in part, on their own genetic makeup. The fetus may also have a direct effect on prenatal maternal mood and later parenting behaviour via the placenta. The father is important prenatally too. An abusive partner can increase the mother's prenatal stress and alter fetal development, but he can also be an important source of emotional support. New research suggests the potential benefits of prenatal interventions, including viewing of prenatal scans and cognitive behavioural therapy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. 产前超声筛查胎儿唇裂和(或)腭裂及相关畸形%Prenatal ultrasound screening for fetal cleft lip and palate and related abnormalities

    Institute of Scientific and Technical Information of China (English)

    甄理; 杨昕; 易翠兴; 欧燕媚; 李东至

    2012-01-01

    Objective To evaluate the sensitivity and specificity of prenatal ultrasound for detecting fetal cleft lip and palate,and the diagnosis rate of associated congenital structural and chromosomal abnormalities.Methods Thirty one thousand two hundred and forty five singleton pregnant women accepted prenatal examination and delivered in Guangzhou Women & Children' s Medical Center from Jan.2006 to Dec.2010 were recruited in this study.All pregnant women underwent prenatal ultrasound screening during second trimester,and whose fetuses were suspected to be cleft lip and palate were suggested to accept karyotype analysis.All babies delivered received oral examination to diagnose cleft lip and palate.Results Cleft lip and palate was diagnosed in 48 cases (1.5‰,48/31 245).Among which,there were 16 cases (33.3%,16/48) of cleft lip,21 cases (43.8%,21/48) of cleft lip with cleft palate and 11 cases (22.9%,11/48) of cleft palate.Prenatal ultrasound screening suggested 18 cases of cleft lip and 14 cases were comfirmed after birth with the accuracy rate of 77.8%,3 cases were diagnosed to be cleft lip with cleft palate and one cases was misdiagnosed.Prenatal ultrasound screening suggested 18 cases of cleft lip with cleft palate in accordance with the diagnosis after birth.Thirteen cases were normal in prenatal ultrasound screening,but two were diagnosed as cleft lip and 11 were diagnosed as cleft palate after birth.The sensitivity of prenatal ultrasound screening for cleft lip and cleft lip with cleft palate was 86.5%(32/37),and the sensitivity for cleft lip and palate was 66.7% (32/48),the false positive rate was 2.1% (1/48).Ten cases (27.8%,10/36) of cleft lip with cleft palate were found to be complicated with other abnormalities.Nine of the 18 cases prenatally diagnosed cleft lip with cleft palate accepted karyotype analysis and 7 were abnormal.Twenty-three of 36 cases with fetal cleft lip and palate in prenatal ultrasound screening were induced

  7. Ultrasound-induced gelation of fluorenyl-9-methoxycarbonyl-l-lysine(fluorenyl-9-methoxycarbonyl)-OH and its dipeptide derivatives showing very low minimum gelation concentrations.

    Science.gov (United States)

    Geng, Huimin; Ye, Lin; Zhang, Ai-Ying; Shao, Ziqiang; Feng, Zeng-Guo

    2017-03-15

    Four l-Lysine(Lys)-l-glutamic acid(Glu) dipeptide derivatives (1-4) and their precursor-a single fluorenyl-9-methoxycarbonyl(Fmoc)-l-Lys(Fmoc)-OH amino acid (5) were demonstrated as gelators to gelate a variety of alcohols and aromatic solvents under the sonication conditions. Compared to the routine heating-cooling protocol, the ultrasound substantially brought down the minimum gelation concentrations (MGCs) of the resulting organogels. The Fourier transform infrared spectroscopy (FT-IR) and fluorescence studies revealed that the π-π stacking and hydrogen bonding act as major driving forces for the self-assembly of these lysine-based gelators into supramolecular fibrous three dimensional (3D) network, where the more the Fmoc protecting groups, the gelators are more responsive to ultrasound-stimulus and more conducive to an ordered molecular arrangement reinforcing the intermolecular forces. Moreover, the ultrasound-triggered organogels of 5 exhibited the thixotropic property. Upon imposing a mechanical shear, its gels with the fibrous 3D network structure were unraveled into sols. However, after standing quiescently over time, these sols returned to the gels showing a more ordered lamella-like packing structure as evidenced by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses.

  8. 产前三维超声TUI技术对胎儿胼胝体发育不全的诊断价值%Value of Tomographic Ultrasound Imaging in Prenatal Diagnosis of Fetal Agenesis of the Corpus Callosum

    Institute of Scientific and Technical Information of China (English)

    林琪; 范海波; 甘晗靖; 孙枫; 吴瑛

    2013-01-01

    Objective To analyze the graphic features of fetal agenesis of the corpus callosum (ACC) detected by tomographic ultrasound imaging(TUI) and assess the value of TUI in the ACC. Methods 3D volume data of 35 cases of fetus with ACC were analyzed with TUI,the sagittal plane median view of the brain was obtained and the outcome was compared with that of two-dimensional (2D) ultrasound. Results There was difference in the revealing rate of ACC between TUI and 2D ultrasound(P<0. 05). Conclusions TUI is a useful tool in the prenatal diagnosis of ACC.%目的 分析三维断层超声显像技术(tomographic ultrasound imaging,TUI)在胎儿胼胝体发育不全(agenesis of the corpus callosum,ACC)中的图像特征,评价TUI诊断胎儿胼胝体发育不全的价值.方法 应用TUI对34例二维可疑ACC的三维容积数据进行后处理分析,获得显示胼胝体最好的胎头正中矢状切面,并将结果与二维超声结果进行比较.结果 TUI技术对ACC的显示率为97.0% (33/34);二维超声对ACC的显示率为52.9% (18/34),二者的显示率差别有统计意义(P<0.05).结论 三维超声TUI技术在胎儿ACC的产前诊断上具有较高的应用价值.

  9. Prenatal ultrasound application in diagnosis and treatment of twin reverse arterial perfusion syndrome%产前超声在双胎反向动脉灌注综合征诊疗中的应用

    Institute of Scientific and Technical Information of China (English)

    谭喜平; 王慧芳; 胡芷洋; 林琪; 冯程

    2009-01-01

    目的 探讨产前超声在双胎反向动脉灌注(TRAP)综合征诊疗中的临床价值.方法 回顾性分析我院产前超声诊断的5例TRAP超声图像、临床资料及妊娠结局,总结TRAP声像学特点.结果 5例TRAP初次确诊孕周为13~28周,均于产后得到证实.彩色多普勒超声检查显示无心畸胎血液循环呈现反向动脉灌注的特点.5例中2例引产;1例流产;1例超声引导下接受无心畸胎减胎术,妊娠至37周分娩;1例在超声密切监测下妊娠至32~(+4)周分娩,新生儿结局良好.结论 产前超声检查对TRAP的早期诊断、预后判断、治疗方案和分娩时机的选择有重要应用价值.%Objective To investigate the value of prenatal ultrasound in diagnosis and treatment of twin reverse arterial perfusion (TRAP) syndrome. Methods A retrospective study was performed in 5 TRAP cases, including ultrasound images, clinical data and pregnancy outcomes. The sonographic characteristics were summarized. Results Five TRAP cases were diagnosed during 13 to 28 weeks' gestation and confirmed after birth. Color Doppler unltrasonography revealed retrograde umbilical artery perfusion towards acardiac twin. Two of 5 cases ended up in induced abortion, 1 in spontaneous abortion, 1 was delivered at 37 weeks' gestation after ultrasound-guided feticide of the acardiac twin and 1 was monitored closely with ultrasound and delivered alive at 32~(+4) weeks' gestation. Conclusion Prenatal ultrasonography has great applicative value for TRAP syndrome in early diagnosis, choosing optimal treatment and prognosis assessment.

  10. Hemimegalencephaly: prenatal diagnosis and outcome.

    Science.gov (United States)

    Alvarez, Rosa María; García-Díaz, Lutgardo; Márquez, Javier; Fajardo, Manuel; Rivas, Eloy; García-Lozano, Juan Carlos; Antiñolo, Guillermo

    2011-01-01

    Hemimegalencephaly (HME) is a developmental abnormality of the central nervous system (CNS) which may present as either a syndromic or isolated case. Here, we present two cases of early prenatal diagnosis of HME. Prenatal CNS ultrasound and MRI in the first case revealed ventricular asymmetry, midline shift with displacement of the occipital lobe across the midline, large dilatation mainly at the posterior horn of the left lateral ventricle, and a head circumference in the 90th percentile without involvement of the brain stem and cerebellum, as well as abdominal lymphangioma. Right hemispherectomy was performed at 3 months of age due to intractable seizures. The pathological specimen showed findings characteristic of HME, including a disorganized cytoarchitecture with lack of neuronal lamination, focal areas of polymicrogyria, and neuronal heterotopias with dysplastic cells. In the second case, 2D and 3D neurosonography demonstrated similar findings (asymmetry of cerebral hemispheres, midline shift, and dilation of the posterior horn of the left lateral cerebral ventricle). Posterior fossa structures were unremarkable. HME was diagnosed and the pregnancy was terminated. Autopsy findings confirmed the diagnosis of HME.

  11. Interobserver agreement in detailed prenatal diagnosis of congenital heart disease by telemedicine using four-dimensional ultrasound with spatiotemporal image correlation

    NARCIS (Netherlands)

    Adriaanse, B.M.; Tromp, C.H.; Simpson, J.M.; Mieghem, T. van; Kist, W.J.; Kuik, D.J.; Oepkes, D.; Vugt, J.M. van; Haak, M.C.

    2012-01-01

    OBJECTIVE: To evaluate the clinical accuracy of four-dimensional (4D) echocardiography in the detailed prenatal diagnosis of congenital heart disease (CHD) in a telemedicine setting. METHODS: Ten second-trimester spatiotemporal image correlation (STIC) volumes were sent to three observers in differe

  12. Cardiovascular Ultrasound of Neonatal Long Evans Rats Exposed Prenatally to Trichloroacetic Acid: Effects on Heart Rate, Ejection Fraction, and Cardiac Output

    Science.gov (United States)

    This abstract describes the use of a relatively new technology, cardiovascular ultrasound (echocardiography) for evaluating developmental toxicity affecting heart development. The abstract describes the effects of two known cardiac teratogens, trichloroacetic acid and dimethadio...

  13. Clinical analysis of 29 cases of fetal digestive tract malformation diagnosed prenatally by ultrasound%产前超声诊断胎儿消化道畸形29例临床分析

    Institute of Scientific and Technical Information of China (English)

    卓娜; 段清; 张晖; 田晶; 孙彤

    2015-01-01

    目的:探讨产前超声检查诊断胎儿消化道发育畸形的临床意义。方法对孕期30~32周于本院检查出存在先天性消化道发育畸形的29例胎儿根据超声图像的不同特点进行分类分析,探讨其不同超声表现。结果29例中无胃泡或小胃泡11例(37.93%),合并多发畸形4例,合并羊水过多9例。管扩张、肠管多囊泡有7例(24.14%),其中合并多发畸形3例,羊水过多3例。双泡征有8例(27.58%),其中合并多发畸形1例,羊水过多7例。另3例无明显超声影像特征。结论30~32周胎儿进行产前超声检查对发现胎儿消化道发育畸形有很高的诊断价值,值得在临床推广应用。%Objective To investigate the clinical significance of prenatal ultrasound examination in the diagnosis of fe⁃tal digestive tract development. Methods Twenty-nine cases of congenital digestive tract malformation were examined in according to the different characteristics of their different fetal ultrasound images. Results There were 11 cases with non-magenblase or less magenblase (37.93%), 4 cases with combination of multiple malformations, and 9 cases with combination of amniotic fluid in the 29 cases. There were 7 cases (24.14%) with dilatation of intestine and intestinal vesicles, in which 3 with multiple malformations and 3 with polyhydramnios. There were 8 cases (27.58%) with double bubbles, in which 1 case with multiple malformations and 7 cases with amniotic fluid. Conclusion The prenatal ultrasound examination in 30 to 32 weeks of pregnancy is very valuable in diagnosis of fetal digestive tract development, which is worthy of clinical application.

  14. Prenatal Diagnosis

    Directory of Open Access Journals (Sweden)

    Ozge Ozalp Yuregir

    2012-02-01

    Full Text Available Prenatal diagnosis is the process of determining the health or disease status of the fetus or embryo before birth. The purpose is early detection of diseases and early intervention when required. Prenatal genetic tests comprise of cytogenetic (chromosome assessment and molecular (DNA mutation analysis tests. Prenatal testing enables the early diagnosis of many diseases in risky pregnancies. Furthermore, in the event of a disease, diagnosing prenatally will facilitate the planning of necessary precautions and treatments, both before and after birth. Upon prenatal diagnosis of some diseases, termination of the pregnancy could be possible according to the family's wishes and within the legal frameworks. [Archives Medical Review Journal 2012; 21(1.000: 80-94

  15. The application of ultrasound-guided amniocentesis in prenatal diagnosis%B超引导下羊膜腔穿刺术在产前诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    黄瑞霞; 孔敏莉; 刘广珍; 梁西岚; 陈小乐; 唐莉

    2011-01-01

    Objective To investigate the safety of B-type ultrasound-guided amniocentesis in prenatal diagnosis, and the values of karyotype analysis of amniocytes and detection of thalassemia gene. Methods 103 women with a gestational age of 16 to 27 weeks who had received ultrasound-guided amniocentesis during November 2009 to January 2011 were included in this study. The amniotic cell culture was performed for chromosomal analysis; For the couples who had the same thalassemia gene, detection of thalassemia gene in amniocytes was performed. Results Amniotic cell culture was successful in 102 of the 103 women. Abnormal karyotype was detectable in 9(8.8%)women, one of whom(11.1%)was 21- trisome and the remaining 8(88.9%)were other abnormal karyotypes. Thalassemia gene was detectable in 24 women, 5 of them(20.8%)had major thalassemia. Conclusions For the pregnant women with abnormal prenatal diagnosis, it is highly necessary to administer ultrasound-guided amniocentesis for karyotype analysis of amniocytes and detection of thalassemia gene. Ultrasound-guided amniocentesis is a safe, effective, reliable, invasive method of prenatal diagnosis.%目的 探讨B超引导下的羊膜腔穿刺术在产前诊断应用中的安全性及羊水细胞染色体核型分析、地中海贫血基因检测在产前诊断中的应用价值.方法 选取2009年11月至2011年1月妊娠16~27周在茂名市妇幼保健院行B超引导下羊膜腔穿刺术的孕妇103例,对羊水中胎儿脱落细胞进行培养,做染色体核型分析;夫妇双方同种类型地中海贫血者,行羊水细胞地中海贫血基因检测.结果 B超引导下的羊膜腔穿刺术103例.羊水细胞培养成功102例,检出异常核型9例,检出率为8.8%,其中三体综合征1例,占11.1%,其他异常8例,占88.9%;羊水地中海贫血基因检测24例,其中重犁地中海贫血5例,占20.8%.结论 产前针对有指征的孕妇于中孕期行B超引导下羊膜腔穿刺术,进行羊水细胞培养染色体核

  16. Prenatal screening and genetics

    DEFF Research Database (Denmark)

    Alderson, P; Aro, A R; Dragonas, T

    2001-01-01

    Although the term 'genetic screening' has been used for decades, this paper discusses how, in its most precise meaning, genetic screening has not yet been widely introduced. 'Prenatal screening' is often confused with 'genetic screening'. As we show, these terms have different meanings, and we...... examine definitions of the relevant concepts in order to illustrate this point. The concepts are i) prenatal, ii) genetic screening, iii) screening, scanning and testing, iv) maternal and foetal tests, v) test techniques and vi) genetic conditions. So far, prenatal screening has little connection...... with precisely defined genetics. There are benefits but also disadvantages in overstating current links between them in the term genetic screening. Policy making and professional and public understandings about screening could be clarified if the distinct meanings of prenatal screening and genetic screening were...

  17. 胎儿胼胝体发育不良的超声和磁共振对比观察%Comparison of ultrasound and MRI in the prenatal diagnosis of agenesis of corpus callosum

    Institute of Scientific and Technical Information of China (English)

    姜小力; 邓学东; 李晓兵

    2011-01-01

    Objective To observe the value of ultrasound (US) and MRI in the prenatal diagnosis of agenesis of corpus callosum (ACC).Methods Fetal ACC was suspected in 16 pregnant women by prenatal US.Fetal MRI was performed within 3 days after prenatal US.The findings of prenatal US and fetal MRI were compared with the results of autopsy or following up imaging data after birth.Results Sixteen fetuses were detected in 16 pregnant women.Fourteen fetuses of ACC suspected with prenatal US were confirmed with MRI (5 confirmed with following-up after birth and 9 with autopsy).Another 2 fetuses were not ACC, 1 was ventriculomegaly companying with gray matter translocation and the other was cerebral white matter and brain stem hypoplasia.Of all the fetal ACC confirmed with MRI, US was consistent with MRI in 7 fetuses, and other 7 fetuses were suspected with US.For the other associated abnormalities in central nervous system,MRI was consistent with prenatal US in 7 fetuses.MRI demonstrated more associated abnormalities than US in 4 fetuses.Conclusion US is the optimal choice for detecting fetal anomalies.However, MRI is superior to US in the diagnosis of ACC and contributes to the definite diagnosis of ACC and possible associated abnormalities.%目的 探讨超声与MRI在胎儿胼胝体发育不良(ACC)产前诊断中的应用价值.方法 超声怀疑胎儿ACC孕妇16名,均在超声检查后3天内接受胎儿MR检查.将超声、MRI结果与出生后或引产后结果对照.结果 16名孕妇共检出胎儿16胎,MRI证实14胎为胎儿ACC(出生后随访证实5胎,引产后证实9胎),1胎为单纯双侧脑室扩张伴灰质易位,1胎为脑白质、脑干发育不良.MRI与超声比较,诊断胎儿ACC一致者7胎;超声可疑、MRI肯定者7胎;对于其伴发中枢神经系统畸形,两者一致者7胎,MRI多于超声者4胎.结论 超声检查是产前筛查胎儿ACC的普遍方法;MRI对胎儿ACC的显示明显优于超声,有助于明确诊断胎儿ACC并判断其分型及合并畸形.

  18. 北京平谷区三年出生缺陷产前超声筛查分析%Prenatal Ultrasound Screening Analysis for the Birth Defects within 3 Years in Pinggu District in Beijing

    Institute of Scientific and Technical Information of China (English)

    刘大平

    2013-01-01

    Objective Ultrasonography in prenatal screening for birth defects diagnosis,understanding of the region the incidence of birth defects,in order to reduce the occurrence of congenital malformation.Methods In 2007,2008,my area,2009 (statistical time for every year from October 1st to next September 30th) delivery within seven days after the diagnosis of birth defects and ultrasound examination results were analyzed.Results In three years the region a total of 162 infants with birth defects,a total of 60 cases of prenatal ultrasound screening detected fetal malformation,and confirmed after birth ultrasound diagnosis correctly,ultrasound screening for the detection rate for 37 %.Missed diagnosis of malformations mainly for cardiac malformation in 45 cases,means (toe) abnormalities in 26 cases,lip,palate 8 cases.Conclusions Ultrasound examination can be detected in the vast majority of congenital fetal malformations,at present this area for gastroschisis,anencephaly and other obvious fetal malformation high detection rate,on minor malformations such as finger (toe) abnormalities in three years has never been detected,on fetal cardiac abnormalities by ultrasonography technology needs to be further improved.%目的 探讨超声产前筛查对出生缺陷的诊断价值,了解本地区出生缺陷的发生动态,为减少先天畸形的发生提供依据.方法 将平谷区2007-2009年(统计时间为每年10月1日至次年9月30日)分娩后7d内诊断的出生缺陷儿与超声检查结果,进行对比分析.结果 3年全区共分娩畸形儿162例,产前超声共筛查出60例畸形胎儿,且出生后证实超声诊断正确,超声筛查的检出率为37%.漏诊心脏畸形45例,指(趾)异常26例,唇、腭裂8例等.结论 超声检查可以检出绝大多数的胎儿先天畸形,目前平谷区对腹裂、无脑儿等明显的胎儿畸形检出率高,对微小畸形如指(趾)异常3年从未检出过,对胎儿心脏异常的超声检查技术有待进一步提高.

  19. Prenatal ultrasound screening for fetal malformation of category in the middle and late preg-nancy:analysis of 1200 cases%中晚孕期产前超声筛查胎儿畸形1200例分析

    Institute of Scientific and Technical Information of China (English)

    曾理; 马继斌; 杨鑫荣

    2015-01-01

    目的:探讨产前超声在胎儿畸形类别筛查中的应用价值。方法2014年2月至2015年3月在我院行胎儿早孕期超声检查正常的孕妇1200例,分别在中孕期(第21~30周)及晚孕期(第31~35周)复查超声。结果中孕期检出畸形胎儿14例(1.17%),其中中枢神经畸形检出率最高(3例),其次是心血管畸形、颜面部畸形、胎儿肿瘤、腹裂、脐膨出、双胎畸形、骨骼及四肢畸形、泌尿系统畸形、呼吸系统畸形、消化系统畸形。晚孕期检出畸形胎儿4例(0.33%),分别为呼吸系统异常、沁尿系统异常、颜面部异常及心脏异常。结论产前超声检查对胎儿畸形的诊断具有重要的意义。超声检查在中孕期对部分畸形类别效果欠佳,因此在孕晚期进行超声检查时需对胎儿的颜面部、呼吸系统及心血管等器官进行筛查,最大程度地降低畸形的漏诊率。%Objective To investigate the clinical value of prenatal ultrasound screening for fetal malformation of category. Methods During the period between February 2014 and March 2015,1200 normal pregnancy women in early pregnancy ultrasound ex-amination were re-examined during the second trimester(21~30 weeks)and the late pregnancy(31~35 weeks).Results Fourteen cases with fetal malformation were detected in the second trimester re-examination(1.17%).Of the 14 cases,the highest positive rate was central nervous system malformation( n=3) followed by cardiovascular malformations,fetal facial malformations,fetal tumors,gas-troschisis,umbilical bulging,twin malformation,skeletal deformity and the four limbs malformation,malformation of the urinary system, and abnormalities of respiratory system and digestive system.In the late pregnancy check,4 fetal malformations were found(0.33%). The malformations were abnormalities of respiratory system、malfarmation of urinary system.cardiovascular malformations and fetal facial malformations

  20. Duplex ultrasound

    Science.gov (United States)

    Vascular ultrasound; Peripheral vascular ultrasound ... A duplex ultrasound combines: Traditional ultrasound: This uses sound waves that bounce off blood vessels to create pictures. Doppler ultrasound: This ...

  1. Control Prenatal

    National Research Council Canada - National Science Library

    P. Susana Aguilera, DRA; M.D. Peter Soothill, MR

    2014-01-01

    Los principales objetivos del control prenatal son identificar aquellos pacientes de mayor riesgo, con el fin de realizar intervenciones en forma oportuna que permitan prevenir dichos riesgos y así...

  2. 产前超声在胎儿染色体异常筛查中的临床价值%The clinical signficance of ultrasound in prenatal diagnosis of chromosome abnomality

    Institute of Scientific and Technical Information of China (English)

    马思思; 叶风; 陈蓉蓉; 陈利民

    2012-01-01

    目的 探讨产前超声在胎儿染色体异常筛查中的临床价值.方法 2008.1~2011.3孕期在我中心行羊水及脐血穿刺3702例病例,诊断染色体核型异常221例,221例孕妇中至少产前在我院接受过1次超声检查者共37例,其中21-三体儿19例,18-三体儿5例,13-三体儿2例,45 - XO儿11例.孕妇年龄21 ~40岁,接受超声检查平均孕周17+~25+周,对其超声声像图进行回顾性分析.结果 本研究37例胎儿,除了8例21-三体儿超声表现未见异常外,另外29例超声均提示至少一个或一个人以上的染色体软指标或结构异常.结论 不同类型的染色体异常有不同的结构畸形谱,了解并掌握不同类型染色体异常各自特定的畸形谱声像图,可以发挥产前超声在胎儿染色体异常筛查中的临床价值.%Objective; To assess the signficance of ultrasound in prenatal diagnosis of chromosome abnomality. Methods: From January 2008 to March 2011, data about 3702 pregnant women and 221 fetuses with chromosome banomalities fetuses (221/3702) were analyzed. The study groups consisted of 19 fetuses with trisomy 21, 5 fetuses with trisomy 18, 2 fetuses with trisomy 13, 11 fetuses with Turner syndrome. In the retrospective study, we evaluated 221 fetuses with gestational age between 17 ~25 weeks and pregnant women age between 21 to 40 years old. Results; At least one or more than one abnormal fetal sonograms were detected in 29 fetuses except 8 fetuses. Conclusion; Chromosomeabnormality have remarkablesonographicsigns. Antenatal ultrasound screening plays an important role in prenatal diagnosis of chromosomal abnomalities.

  3. Fetal MRI in Prenatal Diagnosis of CNS Abnormalities

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2009-02-01

    Full Text Available The value of fetal MRI (fMRI compared to ultrasound in the prenatal detection of CNS abnormalities and impact on counseling were determined in 25 pregnant women examined at University of Dusseldorf, Germany.

  4. Prenatal diagnosis of the acute meconium peritonitis secondary to ileum volvulus perforation: a case report.

    Science.gov (United States)

    Keskin, Uğur; Karasahin, Kazım Emre; Ozturk, Mustafa; Atabek, Cüneyt; Demirbağ, Suzi; Ergün, Ali

    2015-02-01

    This is an unusual case in comparison to other sonographically described prenatal cases due to very early diagnosis and surgical intervention following prompt delivery. A 40-year-old pregnant, ultrasonography showed presence of cystic structure in the fetal abdomen that was consistent with intestinal dilatation. At 32 weeks' of gestation, repeat ultrasound showed collapse of the bowel dilatation along with the presence of hyperechogenic fluid in the fetal abdominal cavity. Cesarean section was performed. The clinical utility of this report is the recognition that meconium peritonitis (MP) may be diagnosed in the acute phase with typical ultrasound features, and should be considered in the differential diagnoses of cases presented with reduced fetal movements. Although it appears that morbidity and mortality in MP cases depend upon gestational age, this case report may help to manage similar cases for defining the appropriate delivery time and treatment modality after prenatal identification of the problem.

  5. Evaluation of the value for prenatal ultrasound applied in diagnosis and identification of congenital pulmonary sequestration%产前超声检查在胎儿隔离肺诊断与鉴别中的价值

    Institute of Scientific and Technical Information of China (English)

    王渝洲; 肖咸英

    2012-01-01

    目的 探讨产前超声检查在胎儿隔离肺诊断与鉴别中的价值,以提高隔离肺的产前诊断率.方法 应用超声检查对15例疑诊胎儿隔离肺孕妇行中晚期系统胎儿畸形筛查,重点扫查胎儿双侧肺,观察病灶的二维超声图像特征,并用CDFI探查病灶的血供来源及内部血流情况,同时注意是否合并其他胎儿结构异常,随访临床影像或病理检查结果.结果 13例胎儿产后病理或影像学检查证实为隔离肺,产前超声诊断的准确率为86.7%(13/15例);2例肺囊腺瘤(13.3%)误诊.胎儿隔离肺典型二维超声图像特征是:胎儿胸腔内或腹腔内强回声或稍强回声团块、呈三角形或叶状、内部回声均匀、边界清.与肺囊腺瘤鉴别诊断的关键是隔离肺供血动脉来自体循环动脉或其分支.结论 产前超声是胎儿隔离肺畸形诊断与鉴别诊断较准确、可靠的方法,具有重要的临床应用价值.%Objective To evaluate the value for prenatal ultrasound applied in diagnosis and identification of congenital pulmonary sequestration. Methods 15 cases of pregnant women suspected fetal PS were examined in the late systemic fetal malformation screening, focus scanning for the fetus with bilateral lung observed lesions of the two dimensional ultrasound images feature, and the blood flow of the blood supply and internal lesions CDFI probe. Also note that a merger of other fetal structural abnormalities, follow up clinical and imaging or pathological examination. Results 13 cases patients with PS were confirmed by the postpartum fetal pathology or imaging studies, the coincidence rate was approximately 86. 7% (13/15),There were 2 cases patients who belonged to missed diagnosis as pulmonary cystadenoma. The PS is characterized by a typical two dimensional ultrasound image of chest or abdominal fetal echogenic mass or slightly stronger echo, triangular or leaf, the internal echo uniform,border clearance. The key to the

  6. Application of Cordocentesis Guided by Transabdominal Ultrasound in Prenatal Diagnosis%超声引导下脐静脉穿刺用于产前诊断的临床分析

    Institute of Scientific and Technical Information of China (English)

    李晓峰; 龚斐; 肖红梅; 谭跃球; 林戈

    2013-01-01

      目的:探讨超声引导下脐静脉穿刺术在产前诊断中的应用。方法:收集中信湘雅生殖与遗传专科医院2004-2012年行超声引导下脐静脉穿刺检测胎儿染色体核型的158份病例(夫妇一方有染色体异常携带组21例,超声发现胎儿异常或可疑畸形、羊水量异常组58例,妊娠妇女血清学筛查高风险组38例,不良生育史组41例),分析手术指征、穿刺并发症等,并追踪其妊娠结局。结果:穿刺成功率100%。异常染色体检出率为6.96%(11/158)。4组间异常染色体检出率比较差异无统计学意义(χ2=7.377,P=0.061)。术后胎儿一过性心动过缓17例(10.8%);短暂性脐带或胎盘出血97例(61.4%),无早产、宫内感染、胎盘早剥等严重并发症。引产11例,出生畸形3例。结论:超声引导下脐静脉穿刺是一种较为安全、有效的产前诊断方法;经产前诊断检查正常也可能出现后期出生缺陷,因此需结合超声等进一步检查以提高诊断效率,有效减少患儿出生。%Objective: To evaluate the efficacy and safety of cordocentesis guided by transabdominal ultrasound during pregnancy for prenatal diagnosis. Methods:The cordocenteses under transabdominal ultrasound guidance were performed in 158 cases with proper indications for fetal chromosome analysis at Reproductive&Genetic Hospital of CITIC-XIANGYA during 2004 to 2012(21 cases of chromosomal anomaly of gravida or her husband,58 cases of hinting abnormal by ultrasound,38 cases of bad pregnancies history,41 cases of serology screening is positive of gravid). The abnormal karyotypes rate,operational indications, complications and pregnancy outcomes were analyzed. Results: The success rate of cordocentesis was 100%. There were 11 abnormal karyotypes in those 158 cases(6.96%)detected by cordocentesis. The difference in the abnormal karyotypes rate among four groups was not significant (χ2=7.377,P=0

  7. A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature

    Directory of Open Access Journals (Sweden)

    Linda Maria Azzurra Pirollo

    2015-01-01

    Full Text Available Pentasomy X is a rare chromosomal abnormality probably due to a nondisjunction during the meiosis. Only four cases prenatally diagnosed were described until now. Our case is the fifth one prenatally diagnosed at 20 weeks of gestational age in a 39-years-old woman. She underwent invasive prenatal diagnosis for her advanced maternal age without any other known risk factor. Amniocentesis performed at 17 weeks showed a female 49, XXXXX karyotype. The ultrasonographic examination revealed nonspecific signs of a mild early fetal growth retardation and no significant increased nuchal fold. The fetal autopsy and the X-ray excluded major malformations. Prenatal diagnosis is often difficult due to the lack of indicative ultrasonographic findings and the rarity of described cases. The influence of the mother’s age on the occurrence of penta-X syndrome has not been determined. Considering the lack of correlation between advanced maternal age and increased risk for pentasomy X, as well as the absence of typical echographic signs, evaluation of the inclusion of a noninvasive prenatal test (NIPT that expands clinical coverage to include the X and Y chromosomes in routine prenatal diagnosis should be considered as well as three-dimensional ultrasound to detect any helpful indicative prognostic signs.

  8. A New Case of Prenatally Diagnosed Pentasomy X: Review of the Literature

    Science.gov (United States)

    Pirollo, Linda Maria Azzurra; Salehi, Leila Baghernajad; Sarta, Simona; Cassone, Marco; Capogna, Maria Vittoria; Piccione, Emilio; Novelli, Giuseppe; Pietropolli, Adalgisa

    2015-01-01

    Pentasomy X is a rare chromosomal abnormality probably due to a nondisjunction during the meiosis. Only four cases prenatally diagnosed were described until now. Our case is the fifth one prenatally diagnosed at 20 weeks of gestational age in a 39-years-old woman. She underwent invasive prenatal diagnosis for her advanced maternal age without any other known risk factor. Amniocentesis performed at 17 weeks showed a female 49, XXXXX karyotype. The ultrasonographic examination revealed nonspecific signs of a mild early fetal growth retardation and no significant increased nuchal fold. The fetal autopsy and the X-ray excluded major malformations. Prenatal diagnosis is often difficult due to the lack of indicative ultrasonographic findings and the rarity of described cases. The influence of the mother's age on the occurrence of penta-X syndrome has not been determined. Considering the lack of correlation between advanced maternal age and increased risk for pentasomy X, as well as the absence of typical echographic signs, evaluation of the inclusion of a noninvasive prenatal test (NIPT) that expands clinical coverage to include the X and Y chromosomes in routine prenatal diagnosis should be considered as well as three-dimensional ultrasound to detect any helpful indicative prognostic signs. PMID:25699192

  9. Aicardi syndrome: Neonatal diagnosis by means of transfontanellar ultrasound

    Institute of Scientific and Technical Information of China (English)

    Claudio; Rodrigues; Pires; Edward; Araujo; Júnior; Adriano; Czapkowski; Sebasti?o; Marques; Zanforlin; Filho

    2014-01-01

    Aicardi syndrome is a rare genetic disease characterized by a characteristic classical trio of neurological clinical abnormalities(spasms),agenesis of the corpus callosum and ophthalmological abnormalities(chorioretinal lacunae).The diagnosis can be suspected by prenatal ultrasound with color Doppler identifying the agenesis of the corpus callosum.Usually,the diagnosis is confirmed in the neonate period by transfontanellar ultrasound and ophthalmological examination.We present a case of newborn with Aicardi syndrome,being the transfontanellar identified partial dysgenesis of the corpus callosum and a cyst in the inter-hemispheric fissure.Ophthalmological examination showed bilateral chorioretinal lacunae.

  10. Value of Prenatal Ultrasound in the Diagnosis of Fetal Complete Atrioventricular Septal Defect%产前超声诊断胎儿完全性房室间隔缺损的价值

    Institute of Scientific and Technical Information of China (English)

    刘志红; 冷萍; 曾宪敏

    2012-01-01

    目的 探讨产前超声心动图诊断胎儿完全性房室间隔缺损(cAVSD)的临床价值.资料与方法 回顾性分析2006~2010产前超声诊断的21例cAVSD胎儿的超声资料,分析其与染色体异常的关系及胎儿的临床结局.结果 产前超声显示12例为单纯cAVSD,9例合并其他结构异常,即复合型cAVSD.12例单纯cAVSD胎儿中2例核型异常,9例复合型房室间隔缺损胎儿中6例核型异常.经产前咨询后,9例孕妇选择终止妊娠;12例胎儿中,4例宫内死亡,出生的8例胎儿中,2例未接受手术在新生儿期死亡;6例接受手术,4例存活均为单纯cAVSD.结论 胎儿cAVSD常合并其他结构畸形,且与染色体异常关系密切.复合型cAVSD结局较差,单纯型cAVSD结局相对较好,但围生期胎儿丢失率超过50%.%Purpose To investigate the diagnostic value of prenatal ultrasound in fetal complete atrioventricular septal defect (cAVSD). Materials and Methods The ultrasonic data of 21 cases of cAVSD diagnosed by prenatal ultrasound from 2006 to 2010 were retrospectively analyzed, and the relationship with chromosomal abnormality as well as fetal clinical outcomes were also explored. Results There were 12 sole cAVSD and 9 complicated with other malformations (complicated cAVSD). Fetal karyotype analysis: 2 with sole cAVSD had abnormal karyotype, and 6 out of the 9 complicated cAVSD had chromosomal abnormalities. Following prenatal counseling, 9 couples chose termination. Of the 12 continuing pregnancies, 4 were lost to follow-up. Of the 8 live births, 2 were neonatal deaths without surgery while 6 babies underwent surgery and 4 had survived to date. All the survivors were sole cAVSD. Conclusion cAVSD is associated with chromosomal and other abnormalities. The outcome of complicated cAVSD is poor, and the outcome of sole cAVSD is better. But the survivors don't reach half of the sole cAVSD.

  11. Study of fluorescence in situ hybridization in prenatal diagnosis of abnormal ultrasound gravida%荧光原位杂交技术在产前超声诊断异常患者中的应用

    Institute of Scientific and Technical Information of China (English)

    周丽颖; 贾婵维; 李颖; 余兰; 梁毓; 兰永连; 王树玉

    2012-01-01

    目的 应用荧光原位杂交(FISH)技术及细胞学对照,评价产前超声诊断异常患者胎儿的染色体异常.方法 应用5种(21、13、18、X和Y)FISH探针,平行细胞染色体分析进行133名产前超声诊断异常孕妇胎儿的染色体核型.结果 133例产前超声诊断异常孕妇,共检出非整倍体异常核型34例,FISH检测与细胞染色体分析结果一致.胎儿颈项透明层(NT)增厚作为标记21-三体综合征的特异性指标,在同时合并高龄(年龄>35岁)的孕妇中,高度提示发生21-三体综合征的可能.结论 荧光原位杂交,能有效检测绝大多数胎儿染色体非整倍体异常.对于NF合并高龄孕妇,应结合该技术确定胎儿染色体是否异常.%Objective: To evaluate the application of fluorescence in situ hybridization (FISH) in prenatal diagnosis of abnormal ultrasound gravida. In the mean time, cytogenetic karyotype analysis was performed as control. Methods; 5 chromosomes (21, 13, 18, X and Y) were detected with FISH. 133 abnormal ultrasound gravidas were selected for investigation. Results; Of all the 133 gravidas, 34 samples were shown with abnormal karyotypes. results of both FISH and cytogenetic karyotype analysis exhibited extreme concordance of 5 chromosomes. As a specify index, nuchal translucens increase and >35 year old was high correlated with trisomy 21 syndrome. Conclusion; FISH can effectively detect most fetal aneuploidy. For abnormal ultrasound gravid with >35 year old, final diagnosis should be done as soon as possible.

  12. Laparoscopic resection of prenatally detected intra-abdominal testicular teratoma: Report of a neonatal case

    Directory of Open Access Journals (Sweden)

    Keigo Yada

    2017-08-01

    Full Text Available Prenatal detection of intra-abdominal testicular tumor is rare. In this paper, we discuss the early laparoscopic resection of prenatally detected testicular tumor of a neonate. At 33 weeks gestation, follow-up ultrasound showed the mass measuring 3 × 2 cm, on the fetal right lower quadrant. After full-term birth, we performed laparoscopic resection of the tumor, on day 14 of life. Histology of 4-cm right testicular tumor revealed immature teratoma. Postoperative course was favorable and no recurrence has occurred 3 years after operation. Prenatal diagnosis of the intra-abdominal testicular teratoma enabled the early tumor resection, and laparoscopic resection of the tumor is safe and feasible, even in a neonate.

  13. Value of standard prenatal ultrasound diagnosis for absent fetal hand%规范产前超声检查诊断胎儿手缺失的价值

    Institute of Scientific and Technical Information of China (English)

    孙小平; 宋风菊; 杜宝琴; 孟红哲; 黄瑛; 张彬; 刘会敏; 郑莉华; 庄英军; 宋兰萍

    2011-01-01

    Objective To evaluate the efficacy of standardized prenatal ultrasound screening used in diagnosis of absent fetal hand. Methods A total of 51 720 pregnant women received the standardized ultrasound screening and color dopplor ultrasonography. The continuous sequence approach ( SCSA ) of ultrasound was used to observe the morphology posture, structure and movement of fetal limbs, especially the themorphology posture and the status of hands. The patients were screened in four stages( 11 to 14 weeks, 18 to 24 weeks, 25 to 32 weeks, 33 to 40 weeks ). 18-24 weeks and 25-32 weeks were two important periods. Results Sixty-two cases were detected with fetal limb deformity, and they can be divided into nine kinds : 1 case of absent forearm, 2 cases of different length of bilateral femoral, 2 cases of absent leg, 7 cases of absent hand, 8 cases of pairs of limb posture abnormalities , 9 cases of radial deficiency, 10 cases of varus foot, 11 cases of short limbs deformity, and 12 cases of multiple fingers( toes ). 21 of the 62 cases were complicated with other malformations, which were confirmed by postnatal operation. 51 cases were detected with fetal limb deformity by prenatal ultrasound exzamination( 82.26% ,51/62 ), and 11cases were missed ( 17.74% , 11/62 ). Only 2 of 7 hand-absent cases combined with other malformations( 1 bilateral fetal polycystic kidney disease, 1 ventricle slightly wider 12 mm ). All 7 hand-absent cases were confirmed by postnatal examination( 7/7 ). Conclusion The standard prenatal ultrasound diagnosis for absent fetal hand is an important diagnostic imaging method.%目的 探讨连续顺序追踪超声法在产前胎儿手缺失筛查中的应用价值.方法 采用连续顺序追踪超声法(SCSA) 对51 720例孕妇分4个阶段(孕11~14周、18~24周、25~32周、33~40周)进行规范化产前超声检查,以18~24周、25~32周作为常规检查肢体的两个重要时期.每一孕周超声筛查时均逐一观察胎

  14. 孕早期胎儿超声结构筛查的必要性探讨%The essentiality of prenatal ultrasound screening of fetal malformations in the first trimester

    Institute of Scientific and Technical Information of China (English)

    戴晨燕; 茹彤; 顾燕; 杨燕; 杨丽娟; 徐燕

    2012-01-01

    Objective; To assess the essentiality of ultrasound screening in detecting the abnormal cases in the first trimester. Methods: The retrospective review included the pregnant women in the first trimester from December 1, 2007 to October 31, 2010 in the Center for prenatal diagnosis in The Affiliated Drum Tower hospital of Nanjing University Medical College. Scan fetal structural with transabdominal ultrasound, the conventional measurement of fetal crown - rump distance ( CRL) , nuchal translucency thickness (NT) , fetal heart rate (HR) , observation of fetal brain, spine, extremities, thoracic and abdominal wall, four - chamber view of the heart, stomach, bladder, double umbilical artery, placental and amniotic fluid volume and other indicators, determine whether fetal structural abnormalities and its appendages. Results; A total of 3000 pregnant women in 11 -13 +6 weeks suffered the examination, in which a single pregnancy in 2514 cases, 478 cases of twin pregnancy, three pregnancy in 8 cases. All of them, there were 91 cases with fetal structural abnormalities. Conclusion: Ultrasound screening in the first trimester can detect out the severe structural abnormalities of fetal at the very onset, and provide the support for further prenatal diagnosis and obstetric treatment. For multiple pregnancy after the discovery of fetal structural abnormalities, but also in judgment of chorionic, to provide the basis for abnormal conditions in the treatment.%目的 通过研究孕早期胎儿超声结构筛查发现的异常病例,探讨孕早期行超声结构筛查的必要性.方法 回顾2007年12月1日至2010年10月31日在南京市鼓楼医院产前诊断中心超声室行孕早期胎儿结构筛查的孕妇,行经腹部超声检查胎儿,常规测量胎儿冠臀距(CRL)、颈项透明层厚度(NT)、胎心率(HR),观察胎儿颅脑、脊柱、四肢、胸腹壁、四腔心结构、胃泡、膀胱、双脐动脉、胎盘及羊水量等指标,明确有无胎儿及其

  15. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... specific content. Related Articles and Media Sonohysterography Ultrasound - Abdomen Children's (Pediatric) Ultrasound - Abdomen Obstetric Ultrasound Ultrasound - Prostate Kidney and ...

  16. Prenatal Care.

    Science.gov (United States)

    Health Resources and Services Administration (DHHS/PHS), Rockville, MD. Office for Maternal and Child Health Services.

    This booklet is the first in a series of publications designed to provide parents with useful information about childrearing. Contents are organized into three parts. Part I focuses on the pregnancy, prenatal care, development of the baby, pregnant lifestyles, nutrition, common discomforts, and problems of pregnancy. Part II provides information…

  17. Prenatal sonographic findings of Beckwith-Wiedemann syndrome: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Won Sang; Lee, Jee Young; Lee, Yeon Hee [Dankook University Hospital, Chonan (Korea, Republic of)

    2000-03-15

    The Backwith-Wiedemann syndrome (BWS) is and unusual complex with variable clinical features. Major findings included defects in the abdominal wall, macroglossia and macrosomia. These features should be amenable to prenatal ultrasound detection. Serious complications are possible in the neonatal period, which may result from the hypoglycemia or the airway obstruction due to macroglossia. Accurate prenatal diagnosis allows optimum prenatal care and prevention of serious complications. We report a case of prenatally diagnosed BWS with omphalocele, macroglossia, nephromegaly and hepatic cyst.

  18. Risks of ultrasound-guide amniocentesis and cordocentesis for prenatal diagnosis%B超引导下脐带及羊膜腔穿刺术风险评估

    Institute of Scientific and Technical Information of China (English)

    应萍; 陈小明; 张秀兰

    2011-01-01

    Objective: To assess the potential risks of ultrasound -guide amniocentesis and cordocentesis for prenatal diagnosis.Methods: From November 2007 to October 2008, 1015 cases who had prenatal diagnosis in our hospital were reviewed, and the pregnant outcomes were followed up by phone. Results: In all cases, there were 18 loss of follow -up and 57 induced labor because of fetal malformation. There were totally 4 cases of fetal loss, one of them had occurred after cordocentesis which were performed twice and through placenta while the other 3 cases happened after operation without through placenta. Conclusion: It may increase the risk of fetal loss that amniocentesis or cordocentesis is taken through placenta, especially with more times of operation.%目的 评价B超引导下脐带及羊膜腔穿刺术的安全性和潜在的风险,为进一步规范操作提供理论依据.方法 回顾本院2008年1月~2009年1月份,在本院进行产前诊断病例总1015例,所有病例进行电话随访至分娩后.对是否经过胎盘穿刺以及不同穿刺次数与妊娠结局之间的关系进行比较.结果 所有病例中,57例因诊断为胎儿异常行引产术,18例失访,剩下940病例中,非引产胎儿自然流失共4例(0.43%),其中1例为经过胎盘且穿刺2次以上者(3.03%),另3例为未经胎盘穿刺者(0.48%).结论 经过胎盘穿刺时,增加穿刺次数可能会增加胎儿不良结局的发生.

  19. Prenatal Diagnosis of Cloacal Exstrophy: A Case Report and Differential Diagnosis with a Simple Omphalocele

    Directory of Open Access Journals (Sweden)

    Ching-Yu Chou

    2015-03-01

    Full Text Available Cloacal exstrophy is a rare congenital disorder that may lead to mortality and morbidity. Although the prenatal diagnosis of cloacal exstrophy can be made by a midtrimester ultrasound, it is difficult to differentiate it from a simple omphalocele that can be corrected completely by surgery without morbidity. We reported a case with cloacal exstrophy and reviewed previous literature on differentiating it from an omphalocele. A 33-year-old, pregnant female visited our outpatient center for prenatal care at the 22nd gestational week. The midtrimester ultrasound showed fetal anomalies including a protruding mass from umbilicus, absence of bladder, ambiguous genitalia, and bilateral renal hydronephrosis. The parents received prenatal genetic counseling and decided to continue the pregnancy. A female baby was delivered at the 37th gestational week via vaginal delivery, and cloacal exstrophy without omphalocele was diagnosed. Cloacal exstrophy is a complicated congenital disorder that should be differentiated from a simple omphalocele. Prenatal counseling and postnatal care in a tertiary medical center are important for parents and the fetus, respectively.

  20. Prenatal screening and genetics

    NARCIS (Netherlands)

    Alderson, P.; Aro, A.R.; Dragonas, T.; Ettorre, E.; Hemminki, E.; Jalinoja, P.; Santalahti, P.; Tijmstra, T.

    Although the term 'genetic screening' has been used for decades, this paper discusses how, in its most precise meaning, genetic screening has not yet been widely introduced. 'Prenatal screening' is often confused with 'genetic screening'. As we show, these terms have different meanings, and we

  1. Prenatal screening and genetics

    NARCIS (Netherlands)

    Alderson, P.; Aro, A.R.; Dragonas, T.; Ettorre, E.; Hemminki, E.; Jalinoja, P.; Santalahti, P.; Tijmstra, T.

    2001-01-01

    Although the term 'genetic screening' has been used for decades, this paper discusses how, in its most precise meaning, genetic screening has not yet been widely introduced. 'Prenatal screening' is often confused with 'genetic screening'. As we show, these terms have different meanings, and we exami

  2. Prenatal screening and genetics

    DEFF Research Database (Denmark)

    Alderson, P; Aro, A R; Dragonas, T

    2001-01-01

    Although the term 'genetic screening' has been used for decades, this paper discusses how, in its most precise meaning, genetic screening has not yet been widely introduced. 'Prenatal screening' is often confused with 'genetic screening'. As we show, these terms have different meanings, and we ex...

  3. Prenatal screening for congenital malformations: diagnosis and ...

    African Journals Online (AJOL)

    care of the pregnancy in terms of antenatal care, and referral for birth as ... photographed and only represent a proportion of all the malformed ... KEY WORDS: foetal malformafion, newborn deaths, prenatal care, pregnancy terminafion. Figure 1. Case 1 ... multiple methods, including ultrasound, are combined to make a ...

  4. Prostate Ultrasound

    Medline Plus

    Full Text Available ... examinations do not use ionizing radiation (as used in x-rays ), thus there is no radiation exposure to the patient. Because ultrasound images are captured in real-time, they can show the structure and ...

  5. 不同孕周产前超声筛查胎儿畸形的临床意义%Clinical value of ultrasound on the prenatal diagnosis of fetal malformation at different gestational age

    Institute of Scientific and Technical Information of China (English)

    张晓新; 张爱青; 杨娅; 贾忠桃; 钱晶; 姜红红

    2013-01-01

    目的:探讨不同孕周产前超声筛查胎儿畸形的临床意义。方法回顾性分析2011年7月至2012年12月均于我院行孕早期(11~13+6周)及中孕早期(14~17+6周)、孕中期(18~27+6周)、孕晚期(28~40+6周)超声筛查的孕妇的筛查结果,并与产后或尸解结果对照。结果5287例胎儿产前超声筛查检出胎儿畸形共计94例(其中复合畸形11例)105项畸形,引产及分娩后证实胎儿畸形110项。未检出的5项胎儿畸形分别为:室间隔缺损2例,多指2例,腭裂1例。孕早期及中孕早期超声筛查检出胎儿畸形15例,以中枢神经系统畸形为主。孕中期筛查检出胎儿畸形77例,中枢神经系统畸形占首位,其次为颜面部畸形、心血管系统畸形。孕晚期筛查检出胎儿畸形13例,分别为中枢神经系统和四肢骨骼系统畸形及腹盆腔占位各3例、颈面部畸形2例、胸腹壁和心血管系统畸形各1例。孕早、中、晚孕期筛查占超声筛查结构异常胎儿的比例分别为14.3%、73.3%、12.4%。结论孕早期及中孕早期超声筛查可对部分严重的胎儿畸形早期诊断,孕中期超声筛查可检出大部分胎儿畸形,孕晚期超声筛查对迟发性畸形有诊断意义。三个阶段超声筛查对诊断胎儿结构异常有着非常重要的临床价值,我们应掌握不同孕周超声筛查的特点,提高检出率,为临床诊断提供可靠的参考。%Objective To evaluate the value of ultrasound on the prenatal diagnosis of fetal malformation at different gestational age. Methods A retrospective analysis was performed in the pregnant women who had been detected by ultrasound in our hospital through the pregnancy trimester (11-17+6, 18-27+6, 28-40+6 week's gestation) from July 2011 to December 2012. Results 105 fetal malformation cases(94 one-malformation cases and 11 complicated-malformation cases) out of 5287 fetuses were detected by

  6. [When should evoke prenatal paternal uniparental disomy 14?].

    Science.gov (United States)

    Boiffard, F; Bénéteau, C; Quéré, M P; Philippe, H J; Le Vaillant, C

    2014-04-01

    The paternal uniparental disomy 14 is a rare malformation syndrome whose postnatal pathognomonic sign is the deformation of the rib as coat hanger. In prenatal, ultrasonographic signs are major recurrent polyhydramnios, a narrow thorax and deformed long bones short and sometimes other anomalies including ends. The authors report one rare case of prenatal paternal uniparental disomy 14 with the deformation of the rib as coat hanger. Prenatally, the narrow deformed thorax can be searched by ultrasound three-dimensional (3D) and/or helical CT and thus represent an aid to prenatal diagnosis.

  7. Prenatal management of anencephaly.

    Science.gov (United States)

    Cook, Rebecca J; Erdman, Joanna N; Hevia, Martin; Dickens, Bernard M

    2008-09-01

    About a third of anencephalic fetuses are born alive, but they are not conscious or viable, and soon die. This neural tube defect can be limited by dietary consumption of foliates, and detected prenatally by ultrasound and other means. Many laws permit abortion, on this indication or on the effects of pregnancy and prospects of delivery on a woman's physical or mental health. However, abortion is limited under some legal systems, particularly in South America. To avoid criminal liability, physicians will not terminate pregnancies, by induced birth or abortion, without prior judicial approval. Argentinian courts have developed means to resolve these cases, but responses of Brazilian courts are less clear. Ethical concerns relate to late-term abortion, meaning after the point of fetal viability, but since anencephalic fetuses are nonviable, many ethical concerns are overcome. Professional guidance is provided by several professional and institutional codes on management of anencephalic pregnancies.

  8. Relationship between fetal congenital heart defects and chromosomal anomalies detected by prenatal ultrasound%产前超声诊断胎儿先天性心脏畸形与染色体异常的关系

    Institute of Scientific and Technical Information of China (English)

    黎新艳; 田晓先; 晁桂华; 韦波

    2012-01-01

    目的 应用超声探讨胎儿先天性心脏畸形与染色体异常的关系.方法 回顾分析我院产前超声检查发现先天性心脏畸形,并行染色体检查的胎儿58例.结果 58例先天性心脏畸形胎儿中复杂畸形39例(67.2%),心内畸形合并心外畸形26例(44.8% );染色体异常16例(27.6%),其中18 -三体综合征9例,21 -三体综合征4例,13 -三体综合征2例,47,XX,+8[16]\\46,XX[44] 1例.结论 不同类型的胎儿先天性心脏畸形与染色体异常的关系不同;当产前超声发现胎儿先天性心脏畸形时,应仔细观察胎儿全身有无畸形及超声软标志,必要时行染色体检查以明确核型.%Objective To explore the relationship between fetal congenital heart defects (CHD)and chromosomal anomalies by ultrasound. Methods Fifty-eight fetuses with CHD and underwent chromosome examination were enrolled in this study, their data were analyzed retrospectively. Results In 58 cases, there were 39 fetuses (67.2% ) of cardiac complicated deformity and 26 fetuses (44.8%) of extra cardiac malformations, 16 fetuses (27.6%) had chromosomal abnormalities including 9 cases of trisomy 18, 4 cases of trisomy 21, 2 cases of trisomy 13, and 1 case of 47, XX,+8 [ 16 ]\\46, XX [ 44 ]. Conclusion Different fetal CHD has different correlation with chromosomal abnormalities. When prenatal ultrasound diagnosis of heart malformations is made, we should check the fetus carefully and perform amniocentesis or umbilical cord blood puncture to confirm the chromosome karyotype when it is necessary.

  9. 产前超声在前脑无裂畸形诊断中的临床价值分析%Diagnostic value of prenatal ultrasound to fetal holoprosencephaly

    Institute of Scientific and Technical Information of China (English)

    林毅; 雷芳

    2014-01-01

    目的:探讨分析产前超声在前脑无裂畸形诊断中的临床价值。方法选取2010年1月至2013年1月接受产前胎儿系统超声检查的15000例孕妇资料进行回顾性分析。结果15000例接受产前胎儿系统超声检查的孕妇中共有11例胎儿被检出存在前脑无裂畸形的现象。其中5例为无叶全前脑畸形,3例胎儿的超声图片显示为半叶前脑无裂畸形,3例胎儿的超声图片信息显示为叶状前脑无裂畸形。合并畸形的情况为3例胎儿为唇腭裂畸形,1例胎儿为无鼻畸形,1例胎儿为眼距畸形,2例胎儿为dandy-w alker综合征。此外还有2例胎儿为羊水多,1例为多囊肾。11例胎儿经过尸检后证实为前脑无裂畸形。结论产前超声检查在前脑无裂畸形诊断中的准确率较高,临床价值较高,值得推广。%Objective To explore the diagnostic value of prenatal ultrasound to fetal holoprosencephaly .Meth-ods A total of 15 000 cases ,receiving ultrasonography examination during Jan .2010 to Jan .2013 in this hospital were chosen to be analyzed .Results Among all 15 000 cases ,11 cases were found as holoprosencephaly ,of which 5 cases were non-forebrain-cleaved deformity ,3 cases were semi- forebrain-cleaved deformity ,and 3 cases were fore-brain-cleaved deformity .3 cases were combined with cleft lips ,1 case was combined with no nose ,1 case was com-bined with eyes distance deformity ,and 2 cases were combined with dandy-walker syndrome .2 cases were polyhydr-amnios ,and 1 case was polycystic kidney .All of the 11 cases were confirmed by corpses .Conclusion The accuracy of prenatal ultrasonography could be high ,and be with important diagnostic value for prenatal diagnosis ,which might be worth to be promoted .

  10. Analysis of the Effect of the Application of Four-dimensional Color Doppler Ultrasound in Prenatal Screening of Fetal Malformation%产前胎儿畸形筛查中四维彩超的应用效果分析

    Institute of Scientific and Technical Information of China (English)

    纪亚梅; 王文俊

    2016-01-01

    目的:探讨产前胎儿畸形筛查中四维彩超的应用效果。方法方便选取2013年1月—2016年2月在该院进行产前筛查的2200例中晚期孕妇作为研究对象,分别对其进行二维彩超及四维彩超检查,根据胎儿出生后情况或引产结果对二维彩超及四维彩超的检出率进行比较。结果二维彩超对胎儿畸形的检出率为76.92%(40/52),四维彩超对胎儿畸形的检出率为96.15%(50/52),四维彩超对胎儿畸形的检出率明显高于二维彩超(P﹤0.01)。结论与二维彩超相比,四维彩超在胎儿畸形检出方面具有明显优势,值得临床推广应用。%Objective To investigate the application effect of four dimensional color Doppler ultrasound in prenatal screen-ing of fetal malformation. Methods 2 200 cases of advanced pregnant women from January 2013 to February 2016 in our hospital were selected as research subjects. Two dimensional color Doppler ultrasound and four-dimensional color Doppler ultrasound examination were carried out on them. According to the results of the fetus after birth or induction of labor, the detection rate of two-dimensional color Doppler ultrasound and four-dimensional color Doppler ultrasound were compared. Results The detection rate of two-dimensional color Doppler ultrasound for fetal malformation was 76.92%(40/52), while that of four-dimensional color Doppler ultrasound was 96.15%(50/52). Thus the detection rate of four-dimensional color Doppler ultrasound was obviously higher than that of two-dimensional color Doppler ultrasound(P﹤0.01). Conclusion Com-pared with two-dimensional ultrasound, four-dimensional color Doppler ultrasound in the detection of fetal abnormalities has obvious advantages, which is worth clinical application.

  11. Obstetrical Ultrasound

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Obstetric Ultrasound Obstetric ultrasound uses sound waves to produce pictures ... limitations of Obstetrical Ultrasound Imaging? What is Obstetrical Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  12. Prostate Ultrasound

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Prostate Ultrasound of the prostate uses sound waves ... the limitations of Prostate Ultrasound Imaging? What is Ultrasound Imaging of the Prostate? Ultrasound is safe and ...

  13. Musculoskeletal Ultrasound

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Musculoskeletal Ultrasound imaging uses sound waves to produce ... Ultrasound Imaging of the Musculoskeletal System? What is Ultrasound Imaging of the Musculoskeletal System? Ultrasound is safe ...

  14. Ultrasound - Scrotum

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Scrotum Ultrasound imaging of the scrotum uses sound ... of Ultrasound Imaging of the Scrotum? What is Ultrasound Imaging of the Scrotum? Ultrasound imaging of the ...

  15. Ultrasound -- Vascular

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Vascular Vascular ultrasound uses sound waves to evaluate ... the limitations of Vascular Ultrasound? What is Vascular Ultrasound? Ultrasound is safe and painless, and produces pictures ...

  16. Hip Ultrasound

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Hip Ultrasound Hip ultrasound uses sound waves to produce pictures ... of Ultrasound Imaging of the Hip? What is Ultrasound Imaging of the Hip? Ultrasound images of the ...

  17. Ultrasound -- Vascular

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Ultrasound - Vascular Vascular ultrasound uses sound waves to evaluate the ... are the limitations of Vascular Ultrasound? What is Vascular Ultrasound? Ultrasound is safe and painless, and produces ...

  18. Evaluation of the prenatal diagnosis of neural tube defects by fetal ultrasonographic examination in different centres across Europe

    NARCIS (Netherlands)

    Boyd, PA; Wellesley, DG; De Walle, HEK; Tenconi, R; Garcia-Minaur, S; Zandwijken, GRJ; Stoll, C; Clementi, M

    2000-01-01

    Objective-Evaluation of prenatal diagnosis of neural tube defects by ultrasound examination in unselected populations across Europe. Setting-Prenatal ultrasound units in areas that report to contributing congenital malformation registers. Methods-All cases with a suspected or confirmed neural tube d

  19. Prenatal diagnosis and management in fetuses with cystic hygromata colli.

    Science.gov (United States)

    Gembruch, U; Hansmann, M; Bald, R; Zerres, K; Schwanitz, G; Födisch, H J

    1988-12-01

    We report on 45 fetuses with prenatally diagnosed bilateral cystic hygromata colli by ultrasound. Two of the 45 cases involved a twin pregnancy with only one fetus showing hygromata colli. In 2 cases there was only isolated hygromata colli. The other 43 cases showed the signs of non-immune hydrops fetalis. The cytogenetic findings were: 9 fetuses with Turner syndrome, 1 fetus with Turner mosaicism, 1 fetus with trisomy 18, 6 fetuses with trisomy 21, 12 fetuses with normal karyotype, and 16 fetuses with a failed chromosome culture. In fetuses with Turner syndrome and normal karyotype the sonographic findings were similar: massive bilateral hygromata colli, substantial fluid accumulations in skin and body cavities, oligohydramnios and intra-uterine growth retardation. In the cases with trisomy 21, the relative size of the hygromata colli was smaller. Intra-uterine growth retardation and oligohydramnios were not observed. The sole survivor of our group (elective pregnancy interruption: 30 cases; intra-uterine death: 14 cases) (karyotype: 46,XY) presented sonographically with massive ascites, a moderate cystic hygroma, and appropriate fetal development, and a normal amniotic fluid quantity. These findings are analysed in order to provide recommendations for prenatal diagnosis, prenatal management and genetic counselling of the couples concerned.

  20. Prenatal screening methods for aneuploidies

    Directory of Open Access Journals (Sweden)

    Madhusudan Dey

    2013-01-01

    Full Text Available Aneuploidies are a major cause of perinatal morbidity and mortality. Therefore, it is the most common indication for invasive prenatal diagnosis. Initially, screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high-risk for aneuploidies were offered invasive testing. New research is now focusing on non-invasive prenatal testing using cell-free fetal DNA in maternal circulation. The advantage of this technique is the ability to reduce the risk of miscarriage associated with invasive diagnostic procedures. However, this new technique has its own set of technical limitations and ethical issues at present and careful consideration is required before broad implementation

  1. 产前不同时期三维超声筛查胎儿唇裂的效果比较%Comparison of prenatal 3D ultrasound screening at different periods for fetal cleft lip

    Institute of Scientific and Technical Information of China (English)

    阳瑞莲

    2014-01-01

    目的:探讨产前不同时期三维超声筛查胎儿唇裂畸形的效果。方法选择2007年8月至2014年6月在衡阳市第一人民医院进行产前检查并确诊胎儿为唇裂的孕妇31例,对其二维图像及三维成像进行对比,研究三维成像对胎儿唇裂的显示率及最佳显示时间。结果31例唇裂中,孕14~19周5例,面部三维成像满意者3例,唇部结构清晰显示者2例(唇裂的三维超声显示率40.0%);孕20~27周17例,面部三维成像满意或基本满意者15例,唇部结构清晰显示者15例(三维超声显示率88.2%);孕28~34周6例,面部三维成像满意或基本满意者3例,唇部结构清晰显示者2例(三维超声显示率33.3%);孕35周~39周3例,仅1例羊水过多患者面部三维成像满意,唇部结构显示清晰(三维超声显示率33.3%)。孕20~27周胎儿唇裂三维成像显示率明显高于孕14~19周(χ2=5.119,P=0.024)、28~34周(χ2=6.933,P=0.008)和35~39周(χ2=4.804,P=0.028),差异均有统计学意义。三维成像满意显示的唇裂中Ⅰ度唇裂3例(15.0%),Ⅱ度唇裂4例(20.0%),Ⅲ度唇裂7例(35.0%),唇裂合并上牙槽突裂3例(15.0%),唇裂合并腭裂3例(15.0%)。结论三维超声诊断胎儿唇裂存在明显的时限性,最佳时间为孕20~27周。%Objective To study the effect of 3D ultrasound screening for fetal cleft lip deformity at different periods .Methods Totally 31 pregnant women ,who had done prenatal examination in the First People ’ s Hospital of Hengyang City during the period of August 2007 to June 2014,were diagnosed with cleft lip .Their 2D images and 3D images were compared to study the display rate and the optimal display time of fetal cleft lip by 3D imaging.Results Of 31 cases of cleft lip, 5 cases were pregnancy at 14-19 gestational weeks, including 3 cases with

  2. Prenatal Diagnosis, Fetal Surgery, Recurrence Risk and Differential Diagnosis of Neural Tube Defects

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    Chih-Ping Chen

    2008-09-01

    Full Text Available Prenatal screening with α-fetoprotein (AFP and ultrasonography have allowed the prenatal diagnosis of neural tube defects (NTDs in current obstetric care, and open spina bifida has been considered a potential candidate for in utero treatment in modern pediatric surgery. This article provides an overview of maternal serum AFP screening, amniotic fluid AFP assays, amniotic fluid acetylcholinesterase immunoassays and level II ultrasound for NTDs, prenatal repair of fetal myelomeningocele, recurrence risk of NTDs, and differential diagnosis of NTDs on prenatal ultrasound.

  3. Pallister-Killian syndrome: difficulties of prenatal diagnosis.

    Science.gov (United States)

    Doray, Bérénice; Girard-Lemaire, Françoise; Gasser, Bernard; Baldauf, Jean-Jacques; De Geeter, Bernard; Spizzo, Michèle; Zeidan, Charles; Flori, Elisabeth

    2002-06-01

    The first prenatal diagnosis of Pallister-Killian syndrome (PKS) was reported by Gilgenkrantz et al. in1985. Since this report, about 60 prenatal cases have been reported but both sonographic and cytogenetic diagnoses remain difficult. Although ultrasound anomalies such as congenital diaphragmatic hernia, polyhydramnios and rhizomelic micromelia in association with fetal overgrowth are very suggestive of the syndrome, they are inconstant and they may even be absent. The mosaic distribution of the supernumerary isochromosome 12p greatly increases these difficulties. No prenatal cytogenetic technique is sensitive enough to ensure prenatal diagnosis and false-negative results have been described on fetal blood, chorionic villi and amniocentesis. We report here two prenatal cases of PKS which illustrate the great variability of the fetal phenotype. In reviewing the 63 reported cases, we attempt to determine ultrasound indicators of the syndrome and to define a cytogenetic strategy. In cases where ultrasound indicators are present, our proposal is first to perform chorionic villus or placental sampling and then amniocentesis when the first cytogenetic result is normal. Fetal blood sampling is the least indicated method because of the low frequency of the isochromosome in lymphocytes. In this cytogenetic strategy, fluorescent in situ hybridization (FISH) and especially interphase FISH on non-cultured cells increases the probability or identifying the isochromosome. A misdiagnosis remains possible when ultrasound is not contributory; the identification of new discriminating ultrasound indicators would be very helpful in this context.

  4. Observation on the development of fetal cerebral sulci by prenatal ultrasound%超声观察胎儿大脑沟回发育及其临床意义

    Institute of Scientific and Technical Information of China (English)

    陈晓康; 林惠通; 吕国荣

    2009-01-01

    Objective To evaluate the pattern of development of fetal cerebral sulei by prenatal ultrasound and its clinical significance. Methods Sixty hundred and ninety-two fetuses at age from 17 to 40 weeks were observed for the development and depth of cerebral sulci (parietal-occipital sulcus, calcarine suleus, central sulcus, eingulate sulcus, cingulate gyrus, and sylvian fissure) by transabdominal ultrasonography. Results Parietal-occipital sulcus,calcarine sulcus,and sylvian fissure were visible at about 19 weeks of gestation, central sulcus was at about 25 weeks, cingulate sulcus and cingulate gyrus were at about 26 weeks. One case of them was considered as cerebral sulei growth retardation due to the signs of invisible parietal-occipital sulcus and sylvian fissure at 24 weeks of gestation. Two cases were considered as cerebral sulci growth retardation due to the signs of invisible parietal occipital sulcus and central sulcus and the shallow blunt shape of sylvian fissure at 29 weeks of gestation. There were positive correlations between the depths of fetal cerebral sulci and gestational weeks, and negative correlations between their relative depths and gestational weeks(all P <0.05), Conclusions Transabdominal ultrasonography can be use to observe the development of fetal cerebral sulci (parietal-occipital sulcus, calcarine sulcus, central sulcus, eingulate sulcus,cingulate gyrus,and sylvian fissure). The depth of cerebral sulci is relative to gestational weeks,and would be considered for prenatal assessment of cerebral sulci maldevelopment, such as cerebral sulci growth retardation and lissencephalia.%目的 探讨产前超声检测胎儿大脑沟回的发育过程及其临床意义.方法 经腹部超声观测692例孕19~39周胎儿大脑沟回(顶枕沟、距状沟、中央沟、扣带沟、扣带回、大脑外侧裂)发生、发展并测量其深度.结果 顶枕沟、距状沟、大脑外侧裂在19周左右可显示.中央沟在25周左右可显

  5. Prostate Ultrasound

    Medline Plus

    Full Text Available ... through blood vessels. Ultrasound imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. Prostate ultrasound, also called transrectal ultrasound, provides ...

  6. A prenatal case with discrepant findings between non-invasive prenatal testing and fetal genetic testings.

    Science.gov (United States)

    Pan, Qiong; Sun, Baojuan; Huang, Xiaoli; Jing, Xin; Liu, Hailiang; Jiang, Fuman; Zhou, Jie; Lin, Mengmeng; Yue, Hongni; Hu, Ping; Ning, Ying

    2014-01-01

    At 17(+4) week, non-invasive prenatal testing (NIPT) results of a 24-years-old mother showed high risk of monosomy X (45, X). Abnormally shaped head and cardiac defects were observed in prenatal ultrasound scan at 19(+3) week. Amniocentesis conducted at 19(+3) week identified karyotype 47, XX, +18, which suggested that the NIPT failed to detect trisomy 18 (T18) in this case. With a further massively parallel sequencing (MPS) of maternal blood, fetal and placental tissues, we found a confined placental mosaicism (CPM) with non-mosaic T18 fetus and multiclonal placenta with high prevalence of 45, X and low level of T18 cells. FISH and SNP-array evidence from the placental tissue confirmed genetic discrepancy between the fetus and placenta. Because the primary source of the fetal cell-free DNA that NIPT assesses is mostly originated from trophoblast cells, the level of T18 placental mosaicism may cause false negative NIPT result in this rare case of double aneuploidy.

  7. 四维彩超在胎儿先天性畸形中的临床诊断价值%Four-dimensional color Doppler ultrasound in examination in prenatal screening of fetal malformation

    Institute of Scientific and Technical Information of China (English)

    罗妙云

    2014-01-01

    目的 探讨四维彩超在胎儿先天性畸形中的诊断价值.方法 随机观察我院2012年1月至2014年1月孕中晚期孕妇1200例产前常规超声检查结果,所有孕妇均进行了二维超声和四维超声检查,并随访至产后1个月,比较二维超声和四维超声诊断胎儿先天性畸形的准确性.结果 经产后临床证实,共发现先天性胎儿畸形34例,其中神经管畸形10例,心脏畸形8例,唇腭裂7例,泌尿系畸形3例,四肢畸形3例,腹部畸形1例,其他2例.四维超声检出畸形31例,与产后符合率91.17%;漏诊3例,其中多指畸形1例,脊柱裂2例.二维超声检出畸形26例,符合率76.47%;漏诊8例,其中唇腭裂2例,多指畸形2例,脊柱裂3例,足内翻1例.二维和四维超声的诊断符合率比较差异具有统计学意义(P<0.05).结论 四维超声更能多方位、多切面观察胎儿宫内发育情况,对诊断胎儿体表畸形具有更直观和准确的判断,具有较高的临床价值.%Objective To investigate the diagnostic value of four-dimensional (4D) color Doppler ultrasound examination in prenatal screening of fetal malformation.Methods 1200 pregnant women were observed and detected by four-dimensional color Doppler and two dimensional ultrasound.The results were compared with the results confirmed by clinical pathology.Results 34 cases were detected with congenital defects; among which,10 got defects in nervous system,8 heart deformity,7 cheilopalatognathus,3 urinary tract malformation,3 limb deformity,1 abdominal deformity,and the other 2 cases.31 cases were detected with deformity by four-dimensional color Doppler,with a postpartum coincidence rate of 91.17%; and 3 cases were misdiagnosed,of which 1 case had polydactyly deformity and 2 cases spina bifida.26 cases were detected with deformity by two-dimensional ultrasony,with a postpartum coincidence rate of 76.47%; and 8 cases were misdiagnosed,of which 2 cases had cleft lip and palate,2 case polydactyly

  8. Family structure and use of prenatal care.

    Science.gov (United States)

    Alves, Elisabete; Silva, Susana; Martins, Simone; Barros, Henrique

    2015-06-01

    This cross-sectional study intended to assess the use of prenatal care according to the family structure in a population with free universal access to prenatal care. In 2005-2006, the Portuguese birth cohort was assembled by the recruitment of puerperae at public maternity wards in Porto, Portugal. In the current analysis, 7,211 were included. Data on socio-demographic characteristics, obstetric history, and prenatal care were self-reported. Single mothers were considered as those whose household composition did not include a partner at delivery. Approximately 6% of the puerperae were single mothers. These women were more likely to have an unplanned pregnancy (OR = 6.30; 95%CI: 4.94-8.04), an inadequate prenatal care (OR = 2.30; 95%CI: 1.32-4.02), and to miss the ultrasound and the intake of folic acid supplements during the first trimester of pregnancy (OR = 1.71; 95%CI: 1.30-2.27; and OR = 1.67; 95%CI: 1.32-2.13, respectively). The adequacy and use of prenatal care was less frequent in single mothers. Educational interventions should reinforce the use and early initiation of prenatal care.

  9. Family structure and use of prenatal care

    Directory of Open Access Journals (Sweden)

    Elisabete Alves

    2015-06-01

    Full Text Available This cross-sectional study intended to assess the use of prenatal care according to the family structure in a population with free universal access to prenatal care. In 2005-2006, the Portuguese birth cohort was assembled by the recruitment of puerperae at public maternity wards in Porto, Portugal. In the current analysis, 7,211 were included. Data on socio-demographic characteristics, obstetric history, and prenatal care were self-reported. Single mothers were considered as those whose household composition did not include a partner at delivery. Approximately 6% of the puerperae were single mothers. These women were more likely to have an unplanned pregnancy (OR = 6.30; 95%CI: 4.94-8.04, an inadequate prenatal care (OR = 2.30; 95%CI: 1.32-4.02, and to miss the ultrasound and the intake of folic acid supplements during the first trimester of pregnancy (OR = 1.71; 95%CI: 1.30-2.27; and OR = 1.67; 95%CI: 1.32-2.13, respectively. The adequacy and use of prenatal care was less frequent in single mothers. Educational interventions should reinforce the use and early initiation of prenatal care.

  10. 胎儿脑灰质异位的产前诊断及文献回顾%Prenatal diagnosis of fetal gray matter heteropia in one case and literature review

    Institute of Scientific and Technical Information of China (English)

    张葵; 李胜利; 华轩; 袁鹰

    2015-01-01

    Objective To investigate the prenatal ultrasonic manifestations of fetal gray matter heterotopias (FGMH) and evaluate the optimal method its prenatal diagnosis. Methods The prenatal and postnatal ultrasound images and MRI images were analyzed for a fetus with a definitive diagnosis of FGMH. The detection rates of FGMH by prenatal ultrasound and MRI reported in literature were compared. Results We identified 11 reports of FGMH from 1998 to 2015, involving 43 cases with prenatal diagnoses. Of the total of 44 cases (including our case), 32 that had been confirmed postpartum had prenatal ultrasound and MRI data, which showed a significantly lower detection rates of FGMH by prenatal ultrasound than by MRI (43.8% vs 93.8%, P<0.001). Conclusions Prenatal ultrasound can only detect subependymal heterotopia with characteristic manifestations, and the detection of other types of FGMH relies on MRI, which is currently the best option for prenatal diagnosis of FGMH.%目的:探讨胎儿大脑灰质异位(FGMH)的产前超声图像特征并评价其最佳产前诊断方法。方法对1例大脑灰质异位产前产后超声图像以及核磁共振图像进行分析,结合产前诊断该病的相关文献进行回顾性分析,比较产前超声及MRI对FGMH的检出率。结果总结1998~2015年文献11篇,结合本文报道1例,产前诊断灰质异位44例,经活产或引产后证实且有产前超声和产前MRI资料者32例,其中超声检出率43.8%,MRI检出率93.8%,二者检出率比较差异有统计学意义(P<0.001)。结论只有室管膜下型大脑灰质异位才有可能为产前超声所发现,其他类型主要依靠MRI。MRI是FGMH最佳产前诊断方法,当产前超声提示灰质异位时都应进一步行MRI检查。

  11. Disorganized Cortical Patches Suggest Prenatal Origin of Autism

    Science.gov (United States)

    ... 2014 Disorganized cortical patches suggest prenatal origin of autism NIH-funded study shows disrupted cell layering process ... study suggests that brain irregularities in children with autism can be traced back to prenatal development. “While ...

  12. Control Prenatal

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    P. Susana Aguilera, DRA.

    2014-11-01

    Full Text Available Los principales objetivos del control prenatal son identificar aquellos pacientes de mayor riesgo, con el fin de realizar intervenciones en forma oportuna que permitan prevenir dichos riesgos y así lograr un buen resultado perinatal. Esto se realiza a través de la historia médica y reproductiva de la mujer, el examen físico, la realización de algunos exámenes de laboratorio y exámenes de ultrasonido. Además es importante promover estilos de vida saludables, la suplementación de ácido fólico, una consejería nutricional y educación al respecto.

  13. Prostate Ultrasound

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    Full Text Available ... Prostate Ultrasound Imaging? What is Ultrasound Imaging of the Prostate? Ultrasound is safe and painless, and produces ... of page What are some common uses of the procedure? A transrectal ultrasound of the prostate gland ...

  14. Ultrasound -- Pelvis

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    Full Text Available ... are the limitations of Pelvic Ultrasound Imaging? What is Pelvic Ultrasound Imaging? Ultrasound is safe and painless, ... through the blood vessels. top of page How is the procedure performed? Transabdominal: For most ultrasound exams, ...

  15. Prostate Ultrasound

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    Full Text Available ... Ultrasound - Prostate Ultrasound of the prostate uses sound waves to produce pictures of a man’s prostate gland ... of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or sonography , ...

  16. Ultrasound - Breast

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Ultrasound - Breast Ultrasound imaging of the breast uses sound waves ... the Breast? What is Ultrasound Imaging of the Breast? Ultrasound is safe and painless, and produces pictures ...

  17. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... Ultrasound - Pelvis Ultrasound imaging of the pelvis uses sound waves to produce pictures of the structures and ... pictures of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or ...

  18. Prostate Ultrasound

    Medline Plus

    Full Text Available ... Z Ultrasound - Prostate Ultrasound of the prostate uses sound waves to produce pictures of a man’s prostate ... pictures of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or ...

  19. Prostate Ultrasound

    Medline Plus

    Full Text Available ... Prostate Ultrasound Imaging? What is Ultrasound Imaging of the Prostate? Ultrasound is safe and painless, and produces ... of page What are some common uses of the procedure? A transrectal ultrasound of the prostate gland ...

  20. Prenatal diagnosis of Carpenter syndrome: looking beyond craniosynostosis and polysyndactyly.

    Science.gov (United States)

    Victorine, Anna S; Weida, Jennifer; Hines, Karrie A; Robinson, Barrett; Torres-Martinez, Wilfredo; Weaver, David D

    2014-03-01

    Carpenter syndrome is an autosomal recessive disorder comprising craniosynostosis, polysyndactyly, and brachydactyly. It occurs in approximately 1 birth per million. We present a patient with Carpenter syndrome (confirmed by molecular diagnosis) who has several unique and previously unreported manifestations including a large ovarian cyst and heterotaxy with malrotation of stomach, intestine, and liver. These findings were first noted by prenatal ultrasound and may assist in prenatally diagnosing additional cases of Carpenter syndrome.

  1. 产前超声在妊娠期多病原体感染胎儿诊断中的应用%The application of prenatal ultrasound in pregnancy with several kinds of pathogen infection

    Institute of Scientific and Technical Information of China (English)

    孙玲玲; 邓学东; 梁泓; 凌晨; 吴凤钰; 殷林亮; 潘琦

    2014-01-01

    Objective To investigate the fetal ultrasonographic features in pregnancies with Toxoplasma (TOX), rubella virus (RV), cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. Methods From January 2011 to March 2013, prenatal ultrasound examination was performed in 545 fetuses with mothers of speciifc positive IgM of TOX, RV, CMV and HSV, detected by enzyme-linked immune sorbent assay (ELISA) in Nanjing Medical University Affiliated Suzhou Hospital. Ultrasonographic features were summarized and pregnancy outcome was followed up in fetuses with abnormal ifndings. Results Among the 545 fetuses, 56 cases with abnormal sonographic ifndings:6 cases with central nervous systerm abnormalities (2 intracranial calcifications, 4 hydrocephaly);9 cases with digestive system abnormalities (1 intrahepatic calcifications, 8 echogenic bowel);2 cases with heart abnormalities (1 interventricular septal defect, 1 right heart enlargement);17 cases with abnormal amniotic fluid volume (16 polyhydramnios, 1 oligohydramnios);3 cases with placental abnormality (1 thick placenta, 2 placenta abnormal calciifcation);13 cases with urinary systerm abmormality appearing as renal sinus separation;and 6 cases with other systerm abnormalities (1 neck lymphatic hygroma, 1 single umbilical artery, 1 sacrococygeal teratoma and 3 intrauterine growth restriction);2 cases of complicated abnormalities. Conclusions Prenatal ultrasonography is signiifcant in detecting serious fetal malformations, such as hydrocephaly, heart abnormalities and characteristic ultrasound features such as intracranial calciifcations, echogenic bowel, placenta abnormal calciifcation complicated with TOX, RV, CMV and HSV infection, providing valuable information for further clinical treatment, such as induced labour.%目的:探讨妊娠期感染弓形体(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)及单纯疱疹病毒(HSV)胎儿异常超声声像图特征。方法对2011年1月至2013年3月在南京

  2. Prenatal 3- and 4-dimensional Ultrasonographic Findings of Giant Fetal Nuchal Hemangioma

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    Jenn-Jhy Tseng

    2007-10-01

    Full Text Available A precise prenatal diagnosis of hemangioma may be uncertain although a variety of the antenatal appearances on 2-dimensional sonography have been reported. A 27-year-old primigravida was referred at 32 weeks of gestation for evaluation of a fetal nuchal mass. Two-dimensional sonography showed an extracranial mixed echogenic mass (65 × 54 × 59 mm occupying the posterior neck. Color Doppler imaging revealed intense hypervascularization. Three-dimensional (3D and 4-dimensional (4D sonography showed that the mass was lobulated, with a lumpy internal structure. Nuchal hemangioma was further confirmed by clinical examination and postnatal magnetic resonance imaging. The tumor began to regress in size when the infant was 7 months old. Prenatal 3D/4D ultrasound techniques could be considered as complementary diagnostic tools for such a tumor. They have the advantages of providing accurate and inexpensive virtual reality images through more realistic interactions with the virtualized in utero condition.

  3. A case of fetal osteogenesis imperfecta type 2A: longitudinal observation of natural course in utero and pitfalls for prenatal ultrasound diagnosis.

    Science.gov (United States)

    Kimura, Ibuki; Araki, Ryota; Yoshizato, Toshiyuki; Miyamoto, Shingo

    2015-10-01

    We present a case of osteogenesis imperfecta (OI) type 2A in which a natural course in utero was observed from 23 weeks' gestation to term. At 23 weeks' gestation, a sonographic examination showed a cloverleaf skull-like head, a narrow thorax, and marked shortening of the long bones with bowing of the femurs and humeri. Follow-up examinations showed that the cloverleaf skull-like head was not evident at 28 weeks' gestation. Discontinuity of the ribs and femurs was observed at 26 and 30 weeks' gestation, respectively. This finding suggested bone fractures, which were confirmed by three-dimensional computed tomography at 32 weeks' gestation. Ultrasonographic findings of bones, including the long bones and calvarium, changed with advancing gestation during the second trimester. Characteristic features of OI type 2A were evident during the late second to early third trimesters. Repeated ultrasonographic examinations together with three-dimensional computed tomography are necessary for the definitive diagnosis of OI type 2A in the second trimester.

  4. Prenatal Diagnosis of WAGR Syndrome

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    Berrin Tezcan

    2015-01-01

    Full Text Available Wilm’s tumour, aniridia, genitourinary abnormalities, and mental retardation (WAGR syndrome is a rare genetic disorder with an estimated prevalence of 1 in 500,000 to 1 million. It is a contiguous gene syndrome due to deletion at chromosome 11p13 in a region containing WT1 and PAX6 genes. Children with WAGR syndrome mostly present in the newborn/infancy period with sporadic aniridia. The genotypic defects in WAGR syndrome have been well established. However, antenatal ultrasonographic presentation of this syndrome has never been reported. Prenatal diagnosis of this condition is possible in some cases with careful ultrasound examination of classical and nonclassical manifestations of this syndrome. The key point for this rare diagnosis was the decision to perform chromosomal microarray analysis after antenatal diagnosis of absent corpus callosum and absent cavum septum pellucidum, as this finding mandates search for potentially associated genetic disorders. We report a case of WAGR syndrome diagnosed prenatally at 29-week gestation. The diagnosis of the anomaly was based on two- and three-dimensional ultrasound as well as fetal MRI scan and microarray analysis. The ultrasonographic findings included borderline ventriculomegaly, absent corpus callosum, and absent cavum septum pellucidum. Cytogenetic results from the amniotic fluid confirmed WAGR syndrome. Parental karyotype was normal, with no evidence of copy number change, deletion, or rearrangement of this region of chromosome 11.

  5. Prenatal Diagnosis of Arachnoid Cysts

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    Chih-Ping Chen

    2007-09-01

    Full Text Available Arachnoid cysts are a rare central nervous system malformation, representing only 1% of all intracranial masses in newborns. Primary (congenital arachnoid cysts are benign accumulation of clear fluid between the dura and the brain substance throughout the cerebrospinal axis in relation to the arachnoid membrane and do not communicate with the subarachnoid space. Secondary (acquired arachnoid cysts result from hemorrhage, trauma, and infection and usually communicate with the subarachnoid space. The common locations of arachnoid cysts are the surface of the brain at the level of main brain fissures, such as sylvian, rolandic and interhemispheric fissures, sella turcica, the anterior cranial fossa, and the middle cranial fossa. Arachnoid cysts may be associated with ventriculomegaly and dysgenesis of corpus callosum. Prenatal ultrasound and magnetic resonance imaging have led to the increased diagnosis of fetal arachnoid cysts. This article provides a thorough review of fetal arachnoid cysts, including prenatal diagnosis, differential diagnosis and associated chromosomal abnormalities, as well as comprehensive illustrations of perinatal imaging findings of fetal arachnoid cysts. Prenatal diagnosis of intracranial hypoechoic lesions should include a differential diagnosis of arachnoid cysts and prompt genetic investigations.

  6. Prenatal diagnostic procedures used in pregnancies with congenital malformations in 14 regions of Europe

    NARCIS (Netherlands)

    Garne, E; Loane, M; de Vigan, C; Scarano, G; de Walle, H; Gillerot, Y; Stoll, C; Addor, MC; Stone, D; Gener, B; Feijoo, M; Mosquera-Tenreiro, C; Gatt, M; Queisser-Luft, A; Baena, N; Dolk, H

    2004-01-01

    Objective To investigate outcomes of ultrasound investigations (US) and invasive diagnostic procedures in cases of congenital malformations (CM), and to compare the use of invasive prenatal test techniques (amniocentesis (AC) versus chorionic villus sampling (CVS)) among European populations. Design

  7. 彩色多普勒超声在非高危胎儿产前心脏筛查中的临床价值%Clinical value of color Doppler ultrasound in prenatal cardiac screening of non-high risk fetus

    Institute of Scientific and Technical Information of China (English)

    彭雪芳; 余卫国; 杨淑君

    2013-01-01

    Objective To investigate the clinical diagnostic value of color Doppler ultrasound in prenatal cardiac screening of non-high risk fetus, so as to reduce the birth rate of neonate with congenital heart disease and peri-neonate mortality as much as possible.Methods The clinical materials of 3780 non-high risk fetus in gestational period of 18-24 weeks monitored in the 421st Hospital of PLA from July 2009 to December 2011 were retrospectively analyzed.These fetuses were screened by combination of left and right ventricular outflow tract section, and four-chamber heart section methods.Results Confirmed by induced labor fetus autopsy and post-natal follow-up, 26 fetus with congenital heart disease were founded (including 12 cases of severe congenital heart disease), the overall incidence of cardiac malformations was 6.9‰; twenty-four cases were confirmed by prenatal Doppler ultrasound screening, two cases (1 case of tetralogy of Fallot, 1 case of ventricular septal defect) were missed, prenatal ultrasound detection rate of 92.3%.Conclusion Color Doppler ultrasound can obtain satisfactory fetal heart sonographic image with clear fetal heart structure, can detect most fetal cardiac malformations, is the preferred method of prenatal screening for fetal congenital heart disease, and has important clinical value in non-high-risk prenatal fetal heart screening.%目的 探讨彩色多普勒超声在非高危胎儿产前心脏筛查中的临床诊断价值,以便尽可能地降低先天性心脏病患儿的出生率及围生儿死亡率.方法 回顾性分析2009年6月~2011年12月解放军第四二一医院联合应用左、右室流出道切面和四腔心切面法对孕18~24周的非高危胎儿进行心脏筛查的3780例临床资料.结果 经引产尸解及产后随访证实,本组共检出先天性心脏病胎儿26例(其中严重先天性脏病12例),心脏畸形的总发生率为6.9‰.24例经产前多普勒超声筛查检出,漏诊2例(法洛四联症1

  8. Prenatal Diagnosis of Non-Syndromic Congenital Heart Defects

    Science.gov (United States)

    Ailes, Elizabeth C.; Gilboa, Suzanne M.; Riehle-Colarusso, Tiffany; Johnson, Candice Y.; Hobbs, Charlotte A.; Correa, Adolfo; Honein, Margaret A.

    2015-01-01

    Objectives Congenital heart defects (CHDs) occur in nearly 1% of live births. We sought to assess factors associated with prenatal CHD diagnosis in the National Birth Defects Prevention Study (NBDPS). Methods We analyzed data from mothers with CHD-affected pregnancies from 1998–2005. Prenatal CHD diagnosis was defined as affirmative responses to questions about abnormal prenatal ultrasounds and/or fetal echocardiography obtained during a structured telephone interview. Results Fifteen percent (1,097/7,299) of women with CHD-affected pregnancies (excluding recognized syndromes and single-gene disorders) reported receiving a prenatal CHD diagnosis. Prenatal CHD diagnosis was positively associated with advanced maternal age, family history of CHD, type 1 or type 2 diabetes, twin or higher order gestation, CHD complexity and presence of extracardiac defects. Prenatal CHD diagnosis was inversely associated with maternal Hispanic race/ethnicity, prepregnancy overweight or obesity, and pre-existing hypertension. Prenatal CHD diagnosis varied by time to NBDPS interview and NBDPS study site. Conclusions Further work is warranted to identify reasons for the observed variability in maternal reports of prenatal CHD diagnosis and the extent to which differences in health literacy or health system factors such as access to specialized prenatal care and/or fetal echocardiography may account for such variability. PMID:24222433

  9. Difficulties with Prenatal Diagnosis of the Walker-Warburg Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Low, A.S.C.; Lee, S.L.; Tan, A.S.A.; Chan, D.K.L.; Chan, L.L. [Singapore General Hospital (Singapore). Depts. of Diagnostic Radiology, Obstetrics and Gynecology and Neonatology

    2005-10-01

    We describe a postnatally diagnosed case of Walker-Warburg syndrome - a form of congenital muscular dystrophy with lissencephaly and eye abnormalities. We reviewed the literature to highlight its clinico-radiological diagnostic features and discuss the difficulties encountered with prenatal diagnosis, especially in cases with no positive family history. An increased awareness of this rare but lethal condition, and a high index of suspicion during routine antenatal ultrasound, could prompt further advanced fetal ultrasonography and magnetic resonance imaging, and aid in timely prenatal diagnosis, management, and counseling. Brain/brainstem, congenital, magnetic resonance imaging, obstetrics, pediatrics, ultrasound.

  10. 产前超声筛查对妊娠中期胎儿复杂先天性心脏畸形的诊断价值%Diagnostic Value of Prenatal Ultrasound Screening on Fetuses with Complex Congenital Heart Malformation in Second Trimester of Pregnancy

    Institute of Scientific and Technical Information of China (English)

    夏曦; 周芬芳; 陈宏; 陈莉

    2014-01-01

    Objective To explore the diagnostic value of prenatal ultrasound screening on fetuses with complex con-genital heart malformation in second trimester of pregnancy. Methods From February 2012 to February 2014,the examination data of prenatal ultrasound screening of 9 300 pregnant women in second trimester of pregnancy in our hospital were retrospectively analyzed,the ultrasound findings and follow - up results were compared. Results The positive rate of complex congenital heart malformation was 0. 29% (27 / 9 300). There was no significant differences of detection rate of endocardial cushion defect, transposition of the great arteries,single atrium or ventricle,left or right heart dysplasia,persistent truncus arteriosus,inter-rupted aortic arch,left ventricular cardiac rhabdomyoma,Fallot's tetrad,outside heart malformations and ventricular septal de-fect between ultrasound findings and the fellow - up results(P > 0. 05). A total of 5 cases(0. 05% )got missed diagnosis,in-cluding one case of Fallot's tetrad,2 cases of pulmonary artery stenosis,2 cases of ventricular septal defect. Conclusion Pre-natal ultrasound screening has a higher accurate diagnosis rate on fetuses with complex congenital heart malformation in second tri-mester of pregnancy,is helpful in reducing the birth rate of fetuses with complex congenital heart malformation and to prenatal and postnatal care.%目的:探讨产前超声筛查对妊娠中期胎儿复杂先天性心脏畸形的诊断价值。方法回顾性分析2012年2月-2014年2月在我院进行产前超声筛查的9300例妊娠中期孕妇的超声检查资料,比较超声检查结果和产后随访结果。结果9300例孕妇共检出27例复杂先天性心脏畸形胎儿,检出率为0.29%。超声筛查对心内膜垫缺损、大动脉转位、单心房/单心室、左心/右心发育不良、永存动脉干、主动脉弓中断、左室横纹肌瘤、法洛四联征、合并心外畸形及室间隔缺损的检出率与随访结

  11. Prenatal ultrasonography and postnatal follow-up of a case of McKusick-Kaufman syndrome

    Directory of Open Access Journals (Sweden)

    Hsing-Fen Tsai

    2014-06-01

    Conclusion: Rare syndromes like MKS may need early comprehensive evaluations and consultations. Although prenatal diagnosis might be impossible for MKS, prenatal awareness by fetal ultrasound is very helpful to assist early management and maternal transfer. The final diagnosis and appropriate management of MKS requires the collaboration of obstetricians, geneticists, pediatricians, and ophthalmologists as soon as abnormal signs are detected in utero.

  12. Prenatal diagnosis of 45,X/46,XY mosaicism--a review and update.

    Science.gov (United States)

    Hsu, L Y

    1989-01-01

    A total of 54 cases with prenatal diagnosis of 45,X/46,XY mosaicism was reviewed. Of 47 cases with information on phenotypic outcome, 42 cases (89.4 per cent) were reported to be associated with a grossly normal male phenotype. Three cases (6.4 per cent) were diagnosed as having mixed gonadal dysgenesis with internal asymmetrical gonads. Two other cases were questionably abnormal. In 40 cases with successful cytogenetic confirmatory studies, the overall rate of cytogenetic confirmation of 45,X/46,XY from tissues derived from fetus/liveborn/placenta was 70.0 per cent. This review shows a major difference in the phenotypic outcome between postnatal diagnosis and prenatal diagnosis. Due to the ascertainment bias, almost all known patients with postnatal diagnosis of 45,X/46,XY mosaicism are phenotypically abnormal. Therefore, caution must be used in translating information derived from postnatal diagnosis to prenatal diagnosis. This review calls for collection of more data on 45,X/46,XY mosaicism diagnosed prenatally, more long-term follow-up of liveborn infants, and pathological studies of all abortuses. Emphasis is placed also on the importance of genetic counselling, ultrasound examination, and cytogenetic confirmation.

  13. Later Prenatal Checkups

    Science.gov (United States)

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... Last reviewed: May, 2011 Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ...

  14. Prenatal Care Checkup

    Science.gov (United States)

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... Careers Archives Health Topics Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ...

  15. Prenatal diagnosis of a fetus with ring chromosomal 15 by two- and three-dimensional ultrasonography.

    Science.gov (United States)

    Britto, Ingrid Schwach Werneck; Regina Silva Herbest, Sandra; Tedesco, Giselle Darahem; Drummond, Carolina Leite; Bussamra, Luiz Claudio Silva; Araujo Júnior, Edward; Ruano, Rodrigo; Ruano, Simone Hernandez; Aldrighi, José Mendes

    2014-01-01

    We report on a prenatal diagnosis of ring chromosome 15 in a fetus with left congenital diaphragmatic hernia (CDH) and severe intrauterine growth restriction (IUGR). A 31-year-old woman, gravida 2 para 1, was referred because of increased nuchal translucency at gestational age of 13 weeks. Comprehensive fetal ultrasound examination was performed at 19 weeks revealing an early onset IUGR, left CDH with liver herniation, and hypoplastic nasal bone. Three-dimensional ultrasound (rendering mode) showed low set ears and depressed nasal bridge. Amniocentesis was performed with a result of a 46,XX,r(15) fetus after a cytogenetic study. A 1,430 g infant (less than third percentile) was born at 36 weeks. The infant presented with respiratory failure and died at 2 h of life. Postnatal karyotype from the umbilical cord confirmed the diagnosis of 15-ring chromosome. We described the main prenatal 2D- and 3D-ultrasound findings associated with ring chromosome 15. The interest in reporting the present case is that CDH can be associated with the diagnosis of 15-ring chromosome because the critical location of the normal diaphragm development is at chromosome 15q26.1-q26.2.

  16. Hidronefrosis prenatal en doble sistema excretor Prenatal hydronephrosis in double excretory system

    Directory of Open Access Journals (Sweden)

    Sandalio Durán Álvarez

    2007-12-01

    hydronephrosis were studied. The maternofetal ultrasound showed a double excretory system. To this end, all the newborns and infants with prenatally detected hydronephrosis and double excretory system diagnosed before or after birth were followed up by evolutive renal ultrasonography, micturition urethrocystography, static or dynamic scintigraphy and, in some cases, by excretory urogram. Double excretory system was found in 7 of the 182 patients (3.8 % with abnormalities of the urinary tract diagnosed before birth. Diagnosis was prenatal in just one of the fetuses (31 weeks of pregnancy. Hydronephrotic dilatation was mild in two fetuses and severe in five. Hydronephrosis had different causes. Upper polar nephrectomy was performed in those cases of ureteral ectopy and obstructed upper ureter, reimplantation in one ureterocele, whereas in another it was confirmed the spontaneous rupture by endoscopy. The rest of the patients were symptomatically treated. The hydronephrosis detected before birth by maternofetal ultrasonography may be associated with a double excretory system. Hydronephrotic dilatation associated with a double excretory system may have different causes, and it is necessary to study carefully and systematically these children and to treat them adequately, since each of them may need a different conduct.

  17. 血清学筛查与胎儿超声检查在18、13三体综合征产前诊断中的应用%Serologic Screening with Fetal Ultrasound Screening in the Prenatal Diagnosis of Edwards Syndrome and Patau Syndrome

    Institute of Scientific and Technical Information of China (English)

    钟萍; 林毅; 田葆东

    2011-01-01

    Objective;To explore the efficacy of serologic screening with fetal ultrasound screening in the prenatal diagnosis of edwards syndrome and patau syndrome. Methods:①78 pregnant women with high-risk of edwards syndrome or patau syndrome by prenatal serological screening who refused to make prenatal diagnosis were followed up (Group A).②56 pregnant women with abnormal fetal ultrasound findings (Group B) and, 134 pregnant women with high risk of edwards syndrome/ patau syndrome by prenatal serological screening (Group C) were underwent chromosome analysis after amniocentesis or puncture of umbilical cord from 18 to 32 weeks. Results;In high risk of 18 trisomy by serological screening, 2 cases with abnormal ultrasound findings terminated the pregnancy, 1 newborn had congenital heart disease after birth in group A. In group B, 3 cases were with 18 trisomy, 3 cases were with 13 trisomy and 7 cases were with the other chromosome abnormality. The incidence of abnormal findings was 23 .21 % (13/56) .Among them, 2 cases with 18 trisomy complicated with high risk of serological screening. In group C, 4 cases were with fetal abnormality, among them 2 cases were conformed diagnosed as 18 trisomy. The incidence of abnormality was2.99%(4/134).Conclusions:It is an effective method to detect 18, 13 trisomy by serum biochemical indicators screening in gravida and fetal ultrasound examination.%目的:探讨利用孕妇血清学筛查和胎儿超声检查进行18、13三体综合征胎儿产前诊断的有效性.方法:①对78例(A组)产前血清学筛查18、13三体高风险孕妇,拒绝进行产前诊断的孕妇进行随访观察.②对56例(B组)首诊主诉胎儿超声检查有结构异常的孕妇、134例(C组)首诊主诉为产前血清学筛查胎儿18三体高风险的孕妇,于孕18 ~32周行羊膜腔穿刺羊水细胞培养,或脐血管穿刺脐血细胞培养染色体分析.结果:A组的18三体筛查高风险孕妇有2例出现B超检

  18. Prostate Ultrasound

    Medline Plus

    Full Text Available ... are the limitations of Prostate Ultrasound Imaging? What is Ultrasound Imaging of the Prostate? Ultrasound is safe ... transducer into the body. top of page How is the procedure performed? In men, the prostate gland ...

  19. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... Pelvis Ultrasound imaging of the pelvis uses sound waves to produce pictures of the structures and organs ... of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or sonography , ...

  20. Prostate Ultrasound

    Medline Plus

    Full Text Available ... gel. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... to-use and less expensive than other imaging methods. Ultrasound imaging uses no ionizing radiation. Ultrasound scanning ...

  1. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... a pelvic ultrasound examination. Doppler ultrasound , also called color Doppler ultrasonography, is a special ultrasound technique that ... and processes the sounds and creates graphs or color pictures that represent the flow of blood through ...

  2. Intravascular ultrasound

    Science.gov (United States)

    IVUS; Ultrasound - coronary artery; Endovascular ultrasound; Intravascular echocardiography ... A tiny ultrasound wand is attached to the top of a thin tube. This tube is called a catheter. The catheter ...

  3. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... three types of pelvic ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently ... pelvic ultrasound: abdominal ( transabdominal ) vaginal ( transvaginal / endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam ...

  4. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... through blood vessels. Ultrasound imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. There are three types of pelvic ultrasound: ...

  5. Prenatal Diagnosis of Congenital Cystic Adenomatoid Malformations: Evolution and Outcome

    Directory of Open Access Journals (Sweden)

    Wei-Shiu Chen

    2009-09-01

    Conclusion: The outcomes of the prenatally detected CCAMs were good in our cases. If the CCAM is not complicated by hydrops fetalis, maintaining the pregnancy with continuing management seems to be a reasonable recommendation. Despite antenatal resolution of CCAM on ultrasound, postnatal examination with chest radiography and computed tomography scan is necessary.

  6. Prenatal detection of rare chromosomal autosomal abnormalities in Europe

    NARCIS (Netherlands)

    Baena, N; De Vigan, C; Cariati, E; Clementi, M; Stoll, C; Caballin, MR; Guitart, M

    2003-01-01

    The aim of the present study was to evaluate the prenatal detection of rare chromosomal autosomal abnormalities by ultrasound (US) examination. Data were obtained from 19 congenital malformation registries from 11 European countries, between 01/07/96 and 31/12/98. A total of 664,340 births were cove

  7. Prenatal detection of rare chromosomal autosomal abnormalities in Europe

    NARCIS (Netherlands)

    Baena, N; De Vigan, C; Cariati, E; Clementi, M; Stoll, C; Caballin, MR; Guitart, M

    2003-01-01

    The aim of the present study was to evaluate the prenatal detection of rare chromosomal autosomal abnormalities by ultrasound (US) examination. Data were obtained from 19 congenital malformation registries from 11 European countries, between 01/07/96 and 31/12/98. A total of 664,340 births were

  8. [Fetal ocular anomalies: the advantages of prenatal magnetic resonance imaging].

    Science.gov (United States)

    Brémond-Gignac, D; Copin, H; Elmaleh, M; Milazzo, S

    2010-05-01

    Congenital ocular malformations are uncommon and require prenatal diagnosis. Severe anomalies are more often detected by trained teams and minor anomalies are more difficult to identify and must be systematically sought, particularly when multiple malformations or a family and maternal history is known. The prenatal diagnosis-imaging tool most commonly used is ultrasound but it can be completed by magnetic resonance imaging (MRI), which contributes crucial information. Fetal dysmorphism can occur in various types of dysfunction and prenatal diagnosis must recognize fetal ocular anomalies. After systematic morphologic ultrasound imaging, different abnormalities detected by MRI are studied. Classical parameters such as binocular and interorbital measurements are used to detect hypotelorism and hypertelorism. Prenatal ocular anomalies such as cataract microphthalmia, anophthalmia, and coloboma have been described. Fetal MRI added to prenatal sonography is essential in detecting cerebral and general anomalies and can give more information on the size and morphology of the eyeball. Fetal abnormality detection includes a detailed family and maternal history, an amniotic fluid sample for karyotype, and other analyses for a better understanding of the images. Each pregnancy must be discussed with all specialists for genetic counseling. With severe malformations, termination of pregnancy is proposed because of risk of blindness and associated cerebral or systemic anomalies. Early prenatal diagnosis of ocular malformations can also detect associated abnormalities, taking congenital cataracts that need surgical treatment into account as early as possible. Finally, various associated syndromes need a pediatric check-up that could lead to emergency treatment.

  9. The Diagnostic Value of Prenatal Ultrasound Screening for Complex Con-genital Cardiac Malformations During the Middle and Middle Pregnancy%中孕期胎儿产前超声筛查对复杂先天性心脏畸形的诊断价值探讨

    Institute of Scientific and Technical Information of China (English)

    李佳; 黄文英; 孙格格

    2015-01-01

    目的 分析妊娠中期胎儿行产前超声筛查对复杂先天性心脏畸形的临床诊断价值. 方法 整群选取该院2014年4月-2015年4月收治的5 800例妊娠中期的孕妇作为研究对象, 对其超声结果与产后的随访记录进行进一步分析. 结果共检出32例胎儿患有复杂先天性心脏畸形,检出率为0.55%.彩色多普勒超声诊断仪对单心房或单心室、大动脉转位、心内膜垫缺损、主动脉弓中断、永存动脉千、左心或右心发育不良、合并心外畸形、法洛四联征、左室横纹肌瘤和室间隔缺损进行筛查时,其检出率和随访记录差异无统计学意义;漏诊率为0.05%,漏诊的患儿分别为肺动脉狭窄、法洛四联征和室间隔缺损各1例. 结论 妊娠中期对胎儿进行产前超声筛查对其复杂先天性心脏畸形的临床诊断准确率较高,可降低复杂先天性心脏崎形胎儿出生率.%Objective To analyze the clinical diagnostic value of prenatal ultrasound screening for complex congenital cardiac mal-formations in the middle trimester of pregnancy. Methods In our hospital in April 2014 to 2015 April of 58 cases of prenatal ul-trasound screening in the second trimester pregnant women as the object of study and analysis of the ultrasonic imaging data and clinical data were retrospectively. The ultrasonic results and postpartum follow-up records for further analysis. Results 5 800 cases of pregnant women were checked out in 32 fetuses with complex congenital heart malformation, the detection rate was 0.55%. Col-or Doppler ultrasonic diagnostic apparatus of single atrial or ventricular, great artery transposition, endocardial cushion defect, aor-tic arch interruption, persistent truncus arteriosus thousand, left right heart or heart development adverse, with extra cardiac malfor-mations, tetralogy of Fallot, left ventricular rhabdomyoma and ventricular septal defect screening, by comparing the detection rate and follow-up record, the

  10. Prenatal toxoplasmosis diagnosis from amniotic fluid by PCR

    Directory of Open Access Journals (Sweden)

    Vidigal Paula Vieira Teixeira

    2002-01-01

    Full Text Available Toxoplasmosis is one of the most common infections all over the world. Most cases are asymptomatic, except in immunosuppressed individuals and fetuses, which can be seriously damaged. Prenatal diagnosis should be made as soon as possible since treatment of the mother can minimize fetal sequelae. Our aim in this study was to test the polymerase chain reaction technique (PCR in 86 samples of amniotic fluid from women who seroconverted during pregnancy. DNA was amplified using external primers and, in a second step, internal primers, in a nested PCR system. Samples were also inoculated into mice and the newborn were evaluated by T. gondii serology, skull x-ray, transfontanel ultrasound, fundoscopic examination, lumbar puncture and clinical examination. PCR was positive in seven cases and negative in 79. Among PCR-positive cases, two were negative by inoculation into mice and by clinical evaluation; among PCR-negative ones, three had clinical evidence of toxoplasmosis and one was positive after inoculation into mice. PCR showed values of sensitivity = 62.5% and specificity = 97.4%; the values of inoculation into mice where 42.9% and 100%, respectively. Although PCR should not be used alone for prenatal diagnosis of congenital toxoplasmosis, it is a promising method and deserves more studies to improve its efficacy.

  11. Prenatal diagnosis in multiple pregnancy.

    Science.gov (United States)

    Taylor, M J; Fisk, N M

    2000-08-01

    Fetal abnormality is more common in multiple than in singleton pregnancies. This, together with the requirement to consider the risks with at least two babies to sample correctly each fetus and to undertake accurately-targeted selective termination, amounts to a major challenge for obstetricians involved in prenatal diagnosis. Early determination of chorionicity should be routine, since this influences not only the genetic risks but also the invasive procedure chosen for karyotyping or genotyping. Assessment of nuchal translucency identifies individual fetuses at risk of trisomy. Contrary to expectation, invasive procedures in twins appear to have procedure-related miscarriage rates that are similar to those in singletons. Instead, contamination remains a concern at chorionic villus sampling. Elective late karyotyping of fetuses may have a role in some countries. Whereas management options for discordant fetal abnormality are relatively straightforward in dichorionic pregnancies, monochorionic pregnancies are at risk of co-twin sequelae after any single intrauterine death. Techniques have now been developed to occlude completely the cord vasculature by laser and/or ultrasound guided bipolar diathermy. Given the complexities associated with prenatal diagnosis, all invasive procedures in multiple pregnancies should be performed in tertiary referral centres. Copyright 2000 Harcourt Publishers Ltd.

  12. 产前超声检查在前置胎盘并胎盘植入诊断中的重要性评价%The Importance of Prenatal Ultrasound in Diagnosis of Placenta Previa Pla-centa Implantation and Evaluation

    Institute of Scientific and Technical Information of China (English)

    许崇惠

    2016-01-01

    Objective Evaluate the importance of prenatal ultrasound diagnosis of placenta previa and placenta implanta-tion. Methods Selected in our hospital in August 2013 to 2015 December 202 cases of placenta previa patients as the ob-ject of study, all patients were in production before the color Doppler ultrasound in the diagnosis of, review analysis the pa-tient's imaging characteristics, determine whether complicated with placenta accreta occurred and the pathology result as the basis, to calculate the accuracy of ultrasound in the diagnosis of. Results The 202 patients with placenta previa, by col-or Doppler ultrasound and pathology diagnosis of complicated with placenta accreta patients have 24 cases and 21 cases, detection rate was 11.4%and 10.4%respectively, no significant difference (P> 0.05), the ultrasound misdiagnosis in 3 cas-es, the total detection accuracy rate is 87.5%. Among them, placenta previa and placenta implantation in the anterior wall of the placenta and in the posterior wall of the placenta when diagnosis accurate rate is 94.12% (16 / 17) and 71.43% (5 / 7), placenta previa and placenta implantation in wall placenta diagnostic accuracy is significantly reduced, compared with sta-tistical difference (P0.05),经超声检查,误漏诊3例,总的检出准确率为87.5%。其中,前置胎盘并胎盘植入在前壁胎盘时和在后壁胎盘时的诊断准确率分别为94.12%(16/17)和71.43%(5/7),前置胎盘并胎盘植入在后壁胎盘时的诊断准确率显著降低,比较差异有统计学意义(P<0.05)。前置胎盘并胎盘植入在后壁胎盘时,出现3例产后大出血情况,并发症发生率为42.86%,前置胎盘并胎盘植入在后壁胎盘时,无一例并发症发生。结论产前超声诊断操作简便、重复性好、经济性好、准确率高,是比较理想的前置胎盘并前壁胎盘植入诊断方法。

  13. 利用母血中胎儿有核红细胞结合血清筛查和三维超声无创性产前诊断唐氏综合征%Noninvasive prenatal screening of Down's syndrome by fetal nucleated erythrocytes detection in maternal blood combined with serum screening and three-dimensional ultrasound

    Institute of Scientific and Technical Information of China (English)

    相文佩; 温子娜; 水丽君; 徐晓燕; 陈汉平

    2011-01-01

    目的:利用母外周血中胎儿有核红细胞结合血清三联筛查及三维超声,建立快速无创性产前诊断唐氏综合征的有效模式.方法:早、中期孕妇共670例,采取血清三联筛查结合三维超声和病史选取唐氏高危孕妇,抽取高危孕妇的外周血,流式细胞术富集母血中的胎儿有核红细胞(Fetal Nucleated Red Blood Cells,FNRBCs);次日进行多重引物原位杂交(mutiprimed in situ labeling,multi-PRINS)检测胎儿细胞21号染色体与Y染色体.结果:通过血清三联筛查和三维超声结合病史筛选出高危孕妇24例,高危孕妇在两日内即可确诊,24例中诊断23例染色体正常胎儿,包括男胎12例、女胎11例;诊断1例男性唐氏综合征胎儿.24例标本检测结果和实际胎儿核型符合.结论:血清三联筛查、超声检查结合病史筛选出高危孕妇,然后利用母血中胎儿有核红细胞进行多重引物原位杂交检测细胞染色体,可作为快速、无创性产前诊断唐氏综合征的有效模式,并可为其他胎儿染色体基因异常或者宫内感染的无创性产前诊断提供参考.%Objective: To establish a rapid and effective noninvasive prenatal diagnostic model of Down's syndrome by fetal nucleated erythrocytes detection in maternal blood combined with serum triple screening and three -dimensional ultrasound. Methods:670 pregnant women of early, middle and late pregnancy were selected, the high risk pregnant women of Down's syndrome were chosen by senun triple screening combined with three - dimensional ultrasound and medical history; the peripheral blood samples of high risk pregnant women were abstracted, flow cytometry was used to enrich fetal nucleated erythrocytes in maternal blood; on the following day, multiple - primer in situ hybridization was used to detect Y chromosome and 21 chromosome in fetal cells. Results:24 high risk pregnant women of Down's syndrome were screened out by serum triple screening combined with

  14. Children's (Pediatric) Abdominal Ultrasound Imaging

    Medline Plus

    Full Text Available ... ultrasound images are captured in real-time, they can show the structure and movement of the body's ... kidneys bladder testicles ovaries uterus Abdominal ultrasound images can be used to help diagnose appendicitis in children. ...

  15. Diagnóstico Prenatal

    OpenAIRE

    2010-01-01

    Diagnóstico Prenatal/ propósitos del diagnóstico prenatal/ Tamizaje a partir del Control Prenatal/ Pacientes de bajo riesgo/ Tamizaje bioquímico/ Pacientes de alto riesgo/ Pruebas invasivas y no invasivas

  16. Prenatal meditation influences infant behaviors.

    Science.gov (United States)

    Chan, Ka Po

    2014-11-01

    Meditation is important in facilitating health. Pregnancy health has been shown to have significant consequences for infant behaviors. In view of limited studies on meditation and infant temperament, this study aims to explore the effects of prenatal meditation on these aspects. The conceptual framework was based on the postulation of positive relationships between prenatal meditation and infant health. A randomized control quantitative study was carried out at Obstetric Unit, Queen Elizabeth Hospital in Hong Kong. 64 pregnant Chinese women were recruited for intervention and 59 were for control. Outcome measures were cord blood cortisol, infant salivary cortisol, and Carey Infant Temperament Questionnaire. Cord blood cortisol level of babies was higher in the intervention group (pmeditation can influence fetal health. Carey Infant Temperament Questionnaire showed that the infants of intervention group have better temperament (pmeditation in relation to child health. Present study concludes the positive effects of prenatal meditation on infant behaviors and recommends that pregnancy care providers should provide prenatal meditation to pregnant women.

  17. Prenatal diagnosis of a de novo 9p terminal chromosomal deletion in a fetus with major congenital anomalies.

    Science.gov (United States)

    Hou, Wen-Chien; Chen, Chih-Ping; Hwang, Kwei-Shuai; Chen, Ying-Chieh; Lai, Yu-Ju; Tien, Chau-Yang; Su, Her-Young

    2014-12-01

    We describe a prenatal ultrasonography diagnosis of omphalocele and symbrachydactyly in a fetus and review the literature on prenatal diagnosis of 9p terminal chromosomal deletions. A 31-year-old woman (gravida 3, para 1) was referred for genetic counseling because a fetal omphalocele had been detected. Prenatal ultrasonography at 17+ weeks of gestational age revealed a singleton female fetus with biometry equivalent to 18 weeks with an omphalocele. In addition, symbrachydactyly was also noted in the right arm; the wrist bones as well as the metacarpals were missing. A chromosomal study was arranged for a congenital anomaly involving omphalocele. We obtained Giemsa-banded chromosomes from fetal tissue cells, and an abnormal male karyotype with a terminal deletion of the short arm of chromosome 9 at band 9p13 was noted. After delivery, the fetus showed omphalocele, symbrachydactyly, trigonocephaly, sex reversal, a long philtrum, low-set ears, telecanthus, and a frontal prominence. Prenatal diagnosis of abnormal ultrasound findings with omphalocele and symbrachydactyly should include the differential diagnosis of a chromosome 9p deletion. Copyright © 2014. Published by Elsevier B.V.

  18. 产前超声监测对双胎妊娠并发症的诊断及治疗选择的价值%The Value of Prenatal Ultrasound Monitoring in the Diagnosis and Management of Twins Pregnancy Complications

    Institute of Scientific and Technical Information of China (English)

    刘新秀; 辜秋阳; 庄勇; 陈玲; 陈晓宇; 甘玲; 许翔; 叶真

    2014-01-01

    目的:探讨双胎妊娠的产前超声监测方法对双胎并发症的诊断及治疗选择的价值。方法回顾性分析81例双胎妊娠孕妇的临床资料和超声监测方法,综合评估是否出现双胎输血综合征(TTTS)、选择性胎儿生长受限(sIUGR)等单绒毛膜双胎(MC双胎)特有的并发症,进行相应分期、分型和监测;随访至妊娠终止。结果81例双胎妊娠中双绒毛膜双羊膜囊双胎(DCDA )40例出现双胎之一宫内死亡1例,双胎生长不一致1例;38例单绒毛膜双羊膜囊双胎(MCDA)出现TTTS 4例,sIUGR 2例,双胎之一唇腭裂畸形1例,双胎之一宫内死亡1例;3例单绒毛膜单羊膜囊双胎(MCMA)并发双胎之一无心畸形1例,联体双胎1例。DCDA并发症明显小于MC双胎并发症(P<0.05)。DCDA双胎丢失率1/80(胎),MC双胎丢失率11/82(胎)。DCDA胎儿丢失率明显低于MC双胎胎儿丢失率( P<0.05)。产前超声监测与终止妊娠结果100%符合。结论早孕期诊断双胎妊娠的绒毛膜性具有重要的临床意义;对<26孕周的 MC双胎每2周监测1次,可早期诊断并发症;对≥26孕周的 TTTS及sIUGR在超声严密监测下选择分娩时机,可提高MC双胎围生儿生存率。%Objective To explore the value of prenatal ultrasound monitoring in the diagnosis and the treatment of the twin pregnancy complications . Methods The clinical data and ultrasound follow up medical files of 81 pregnant women with twin pregnancies were retrospectively analyzed during the study period (March 2011~ April 2014) . Twin to twin transfusion syndrome (TTTS) and selective intra-uterine growth restriction(sIUGR) and other complications were comprehensively assessed ,classified and moni-tored . All the cases were followed-up until pregnancy has been terminated . Results Among 81 cases of twins pregnancy ,forty cases were dichorionic-diamniotic twins pregnancies (DCDA) in which

  19. Detection of fetal chromosomal anomalies: does nuchal translucency measurement have added value in the era of non-invasive prenatal testing?

    Science.gov (United States)

    Lichtenbelt, K D; Diemel, B D M; Koster, M P H; Manten, G T R; Siljee, J; Schuring-Blom, G H; Page-Christiaens, G C M L

    2015-07-01

    The objective of this study is to determine what percentage of fetal chromosomal anomalies remains undetected when first trimester combined testing is replaced by non-invasive prenatal testing for trisomies 13, 18, and 21. We focused on the added clinical value of nuchal translucency (NT) measurement. Data on fetal karyotype, ultrasound findings, and pregnancy outcome of all pregnancies with an NT measurement ≥3.5 mm were retrospectively collected from a cohort of 25,057 singleton pregnancies in which first trimester combined testing was performed. Two hundred twenty-five fetuses (0.9 %) had an NT ≥3.5 mm. In 24 of these pregnancies, a chromosomal anomaly other than trisomy 13, 18, or 21 was detected. Eleven resulted in fetal demise, and ten showed fetal ultrasound anomalies. In three fetuses with normal ultrasound findings, a chromosomal anomaly was detected, of which one was a triple X. In three out of 25,057 pregnancies (0.01%), non-invasive prenatal testing and fetal ultrasound would have missed a chromosomal anomaly that would have been identified by NT measurement. © 2015 John Wiley & Sons, Ltd. © 2015 John Wiley & Sons, Ltd.

  20. 产前系统性超声筛查在中晚期孕妇检查中的诊断价值%Diagnostic value of systematic prenatal ultrasound screening of pregnant women in the middle and late of pregnancy

    Institute of Scientific and Technical Information of China (English)

    陈宏建; 陆得秀; 曹蕊; 茆在梅

    2014-01-01

    目的:探讨产前系统性超声筛查在中晚期孕妇检查中的诊断价值。方法总结和分析仪征市中医院2010年5月至2014年3月对孕22~32周3550例中晚期孕妇进行产前系统性超声筛查结果。结果本组3550例胎儿筛查中,胎儿畸形共80例(2.25%),单发畸形71例,多发畸形9例,其中漏诊5例(0.14%)。在单发畸形中,神经系统畸形17例、泌尿系统畸形12例、心脏畸形10例、消化系统(包括腹部)畸形11例、骨骼系统畸形5例、呼吸系统畸形4例、颈面部8例、其他畸形4例。在漏诊5例中,胎儿复杂心脏畸形1例、腭裂1例、膀胱部分外翻1例、足内翻1例、肛门闭锁1例。结论产前系统性超声筛查对胎儿诊断检查中具有较高特异性和准确性,应作为产前孕妇检查的常规检查手段。%Objective To explore diagnostic value of systematic prenatal ultrasound screening of pregnant women in the middle and late of pregnancy. Methods Summary and analysis into 3 550 cases of prenatal ultrasound screening of pregnant women in between 22nd and 32nd of pregnancy. Results Among the 3 550 cases in this arti-cle, 80 of them were fetal anomaly (2.25%), including 71 single malformation and 9 multiple malformations. Five were missed diagnosed. Single malformation consisted of 17 nervous system malformations, 12 urinary system malforma-tions, 10 heart malformations, 11 digestive system malformations (including abdominal), 5 skeletal malformations, 4 respiratory system malformations, 8 neck facial malformations, 4 other forms of malformation. Five missed diagnosed cases consisted of 1 congenital heart malformation, 1 cleft palate, 1 partial bladder exstrophy, 1 talipes varus, 1 proc-tatresia. Conclusion Systematic prenatal ultrasound screening has a high value of specificity and accuracy, thus it should be a routine examination for pregnant women.

  1. Genetic Counseling and Prenatal Diagnosis of Triploidy During the Second Trimester of Pregnancy

    Science.gov (United States)

    Kolarski, Milenko; Ahmetovic, Begzudin; Beres, Maja; Topic, Radomir; Nikic, Vedran; Kavecan, Ivana; Sabic, Semin

    2017-01-01

    Introduction: Triploidy is a lethal chromosomal numeric abnormality, characterized on extra haploid set of chromosomes. It occurs in 2 to 3% of conceptuses and accounts for approximately 20% of chromosomally abnormal first-trimester miscarriages. As such, triploidy is estimated to occur in 1 of 3,500 pregnancies at 12 weeks’, 1 in 30,000 at 16 weeks’, and 1 in 250,000 at 20 weeks’ gestation. Case report: We present a case of second-trimester triploidy diagnosed prenataly at our center. 28-years-old gravida with a first spontaneous pregnancy had early gestational hypertension. Ultrasound examination in 146/7 weeks’ gestation revealed asymmetric intrauterine growth retardation. We recommended biochemical maternal serum screening during second trimester of pregnancy (AFP, HCG, uE3). Result of biochemical screening was indication for cytogenetic analysis from amniotic fluid cells and we recommended early amniocentesis in 156/7 weeks’ gestation. Result showed abnormal karyotype of the fetus (69,XXX triploidy), and DNA analysis confirmed Type-2 Diginy. Parents decided to terminate this pregnancy, and it was done at 22 weeks’ gestation. Conclusion: We emphasize the importance of non-invasive prenatal exminationes-biochemical serum screening during second trimester of pregnancy, and ultrasound examinations in prenatal screening of syndroma Down and other chromosomal abnormalities. PMID:28790549

  2. Prostate Ultrasound

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    Full Text Available ... as detailed as with the transrectal probe. An MRI of the pelvis may be obtained as an ... Benign Prostatic Hyperplasia (BPH) Prostate Cancer Ultrasound- and MRI-Guided Prostate Biopsy Images related to Ultrasound - Prostate ...

  3. Prostate Ultrasound

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    Full Text Available ... is done because a potential abnormality needs further evaluation with additional views or a special imaging technique. ... other imaging methods. Ultrasound imaging uses no ionizing radiation. Ultrasound scanning may be able to give a ...

  4. Ultrasound -- Pelvis

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    Full Text Available ... needles are used to extract a sample of cells from organs for laboratory testing. Doppler ultrasound images ... ultrasound, measures the direction and speed of blood cells as they move through vessels. The movement of ...

  5. Ultrasound -- Pelvis

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    Full Text Available ... the procedure? In women, a pelvic ultrasound is most often performed to evaluate the: uterus cervix ovaries ... page How is the procedure performed? Transabdominal: For most ultrasound exams, you will be positioned lying face- ...

  6. Ultrasound -- Pelvis

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    Full Text Available ... transducer into the body. Doppler ultrasound, a special application of ultrasound, measures the direction and speed of ... understanding of the possible charges you will incur. Web page review process: This Web page is reviewed ...

  7. Ultrasound -- Pelvis

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    Full Text Available ... menstrual problems Ultrasound exams also help identify: palpable masses such as ovarian cysts and uterine fibroids ovarian ... In children, pelvic ultrasound can help evaluate: pelvic masses pelvic pain ambiguous genitalia and anomalies of pelvic ...

  8. Ultrasound -- Pelvis

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    Full Text Available ... bladder seminal vesicles prostate Transrectal ultrasound, a special study usually done to provide detailed evaluation of the ... time to the procedure. If a Doppler ultrasound study is performed, you may actually hear pulse-like ...

  9. Ultrasound -- Pelvis

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    Full Text Available ... of page What are some common uses of the procedure? In women, a pelvic ultrasound is most ... child's favorite channel. top of page What does the equipment look like? Ultrasound scanners consist of a ...

  10. Ultrasound -- Pelvis

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    Full Text Available ... ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently used to evaluate the ... vaginal ( transvaginal , endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam may be part of ...

  11. Ultrasound -- Pelvis

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    Full Text Available ... ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently used to evaluate the ... vaginal ( transvaginal / endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam may be part of ...

  12. Ultrasound -- Pelvis

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    Full Text Available ... 3-D ultrasound or sonohysterography for patients with infertility. In this setting, three-dimensional ultrasound provides information ... the transducer is pressed against the skin, it directs small pulses of inaudible, high-frequency sound waves ...

  13. Prostate Ultrasound

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    Full Text Available ... 20 minutes. top of page What will I experience during and after the procedure? Ultrasound exams in ... ultrasound , there are no known harmful effects on humans. top of page What are the limitations of ...

  14. Ultrasound -- Pelvis

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    Full Text Available ... insertion. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... to-use and less expensive than other imaging methods. Ultrasound imaging is extremely safe and does not ...

  15. Prostate Ultrasound

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    Full Text Available ... top of page What are the benefits vs. risks? Benefits Ultrasound is widely available, easy-to-use ... procedures such as needle biopsies and fluid aspiration. Risks For standard diagnostic ultrasound , there are no known ...

  16. Ultrasound -- Pelvis

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    Full Text Available ... diagnose symptoms experienced by women such as: pelvic pain abnormal vaginal bleeding other menstrual problems Ultrasound exams ... pelvic ultrasound can help evaluate: pelvic masses pelvic pain ambiguous genitalia and anomalies of pelvic organs early ...

  17. Ultrasound -- Pelvis

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    Full Text Available ... Most ultrasound scanning is noninvasive (no needles or injections). Occasionally, an ultrasound exam may be temporarily uncomfortable, ... the following text box: Comment: E-mail: Area code: Phone no: Thank you! Images × Image Gallery Radiologist ...

  18. Ultrasound -- Pelvis

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    Full Text Available ... investigation of the uterine cavity . Three-dimensional (3-D) ultrasound permits evaluation of the uterus and ovaries ... abnormal uterine bleeding Some physicians also use 3-D ultrasound or sonohysterography for patients with infertility. Three- ...

  19. Ultrasound -- Pelvis

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    Full Text Available ... For most ultrasound exams, you will be positioned lying face-up on an examination table that can ... ovaries. Transvaginal ultrasound is usually performed with you lying on your back, possibly with your feet in ...

  20. Ultrasound -- Pelvis

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    Full Text Available ... investigation of the uterine cavity . Three-dimensional (3-D) ultrasound permits evaluation of the uterus and ovaries ... abnormal uterine bleeding Some physicians also use 3-D ultrasound or sonohysterography for patients with infertility. In ...

  1. Endoscopic ultrasound

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/007646.htm Endoscopic ultrasound To use the sharing features on this page, please enable JavaScript. Endoscopic ultrasound is a type of imaging test. It is ...

  2. Prostate Ultrasound

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    Full Text Available ... evaluation with additional views or a special imaging technique. A follow-up examination may also be necessary ... to-use and less expensive than other imaging methods. Ultrasound imaging uses no ionizing radiation. Ultrasound scanning ...

  3. Prostate Ultrasound

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    Full Text Available ... chest. To obtain high-quality images, an ultrasound transducer – a plastic cylinder about the size of a ... or sonography , involves the use of a small transducer (probe) and ultrasound gel placed directly on the ...

  4. Ultrasound -- Pelvis

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    Full Text Available ... by women such as: pelvic pain abnormal vaginal bleeding other menstrual problems Ultrasound exams also help identify: ... fibroids cancer, especially in patients with abnormal uterine bleeding Some physicians also use 3-D ultrasound or ...

  5. Ultrasound -- Pelvis

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    Full Text Available ... insertion. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... time to the procedure. If a Doppler ultrasound study is performed, you may actually hear pulse-like ...

  6. Ultrasound -- Pelvis

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    Full Text Available ... in x-rays ), thus there is no radiation exposure to the patient. Because ultrasound images are captured ... system disorders in both sexes without x-ray exposure. Risks For standard diagnostic ultrasound , there are no ...

  7. Ultrasound -- Pelvis

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    Full Text Available ... needles are used to extract a sample of cells from organs for laboratory testing. Doppler ultrasound images ... ultrasound, measures the direction and speed of blood cells as they move through vessels. The movement of ...

  8. Ultrasound -- Pelvis

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    Full Text Available ... ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently used to evaluate the ... vaginal ( transvaginal / endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam may be part of ...

  9. Ultrasound -- Pelvis

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    Full Text Available ... Ultrasound is safe, noninvasive and does not use ionizing radiation. This procedure requires little to no special preparation. ... create an image. Ultrasound examinations do not use ionizing radiation (as used in x-rays ), thus there is ...

  10. Ultrasound -- Pelvis

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    Full Text Available ... and fluid aspiration. Pelvic ultrasound can help to identify and evaluate a variety of urinary and reproductive system disorders in both sexes without x-ray exposure. Risks For standard diagnostic ultrasound , there are no known ...

  11. Ultrasound -- Pelvis

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    Full Text Available ... of page What are some common uses of the procedure? In women, a pelvic ultrasound is most ... child's favorite channel. top of page What does the equipment look like? Ultrasound scanners consist of a ...

  12. Prostate Ultrasound

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    Full Text Available ... of page What will I experience during and after the procedure? Ultrasound exams in which the transducer ... a regular ultrasound imaging probe on the perineal skin of the patient, between the legs and behind ...

  13. [The role of fetal echocardiography in the prenatal diagnosis of aneuploidy based upon prenatally diagnosed patau syndrome fetuses (case analysis)].

    Science.gov (United States)

    Janiak, Katarzyna; Kaczmarek, Piotr; Krasoń, Aneta; Nowicki, Grzegorz; Piotrowicz, Małgorzata; Respondek-Liberska, Maria

    2002-07-01

    Assessment of usefulness of the fetal echocardiography and genetic sonography in prenatal diagnosis trisomy 13 (retrospective analysis). Between 1994-1999 at the Department for Diagnosis of Congenital Malformation at the Institute of PPMH in 11 fetuses with Patau Syndrome ultrasound and echocardiography examination were performed. In our study the most of cases come from low risk of pregnant women. Fetal heart defect was the most common anomaly diagnosed prenatally in fetuses with Patau Syndrome (7/11), the second one were central nervous system anomalies (6/11) and genitourinary system anomalies (6/11).

  14. Carotid Ultrasound

    Science.gov (United States)

    ... this page from the NHLBI on Twitter. Carotid Ultrasound Also known as carotid duplex. Carotid ultrasound is a painless imaging test that uses high- ... of your carotid arteries. This test uses an ultrasound machine, which includes a computer, a screen, and ...

  15. Non-Invasive Prenatal Diagnosis of Lethal Skeletal Dysplasia by Targeted Capture Sequencing of Maternal Plasma.

    Directory of Open Access Journals (Sweden)

    Shan Dan

    Full Text Available Since the discovery of cell-free foetal DNA in the plasma of pregnant women, many non-invasive prenatal testing assays have been developed. In the area of skeletal dysplasia diagnosis, some PCR-based non-invasive prenatal testing assays have been developed to facilitate the ultrasound diagnosis of skeletal dysplasias that are caused by de novo mutations. However, skeletal dysplasias are a group of heterogeneous genetic diseases, the PCR-based method is hard to detect multiple gene or loci simultaneously, and the diagnosis rate is highly dependent on the accuracy of the ultrasound diagnosis. In this study, we investigated the feasibility of using targeted capture sequencing to detect foetal de novo pathogenic mutations responsible for skeletal dysplasia.Three families whose foetuses were affected by skeletal dysplasia and two control families whose foetuses were affected by other single gene diseases were included in this study. Sixteen genes related to some common lethal skeletal dysplasias were selected for analysis, and probes were designed to capture the coding regions of these genes. Targeted capture sequencing was performed on the maternal plasma DNA, the maternal genomic DNA, and the paternal genomic DNA. The de novo pathogenic variants in the plasma DNA data were identified using a bioinformatical process developed for low frequency mutation detection and a strict variant interpretation strategy. The causal variants could be specifically identified in the plasma, and the results were identical to those obtained by sequencing amniotic fluid samples. Furthermore, a mean of 97% foetal specific alleles, which are alleles that are not shared by maternal genomic DNA and amniotic fluid DNA, were identified successfully in plasma samples.Our study shows that capture sequencing of maternal plasma DNA can be used to non-invasive detection of de novo pathogenic variants. This method has the potential to be used to facilitate the prenatal diagnosis

  16. 产前超声检查对胎儿眼部异常的检测价值%Detective value of prenatal ultrasonography for the fetal eye abnormalities

    Institute of Scientific and Technical Information of China (English)

    郑磊; 温佳敏; 张福燕

    2015-01-01

    胎儿眼部先天性异常是一类罕见的疾病,产前较难诊断.产前超声检查被认为具有检查方便、无创伤、重复性好等优点.通过产前超声检查可发现胎儿眼部的先天异常,如先天性白内障、先天性无眼球或小眼球、永存原始玻璃体增生症等.超声检查可直观地显示不同孕周胎儿的眼部结构,具有提示和诊断先天性眼部异常的临床价值.%Fetal eye abnormalities are a type of rare diseases,which are always difficult to diagnose.Prenatal ultrasound has many advantages,such as convenient,non-invasive and good repeatability.In recent years,many specialists have reported some fetal eye abnormalities detected by prenatal ultrasound,such as congenital cataract,anophthalmia or microphthalmia,persistent hyperplastic primary vitreous.Prenatal ultrasound can visually display the ocular structure of fetus in different gestational age,showing clinical value for diagnosis of fetal eye abnormalities.

  17. 产前超声联合磁共振成像在单纯性腹股沟斜疝临床诊断中的应用%Prenatal diagnosis of ultrasound and MRI in the simple fetal indirect hernia

    Institute of Scientific and Technical Information of China (English)

    刘沁; 杨小红; 陈欣林; 余旭东; 杨文忠

    2015-01-01

    ObjectiveTo explore the clinical value of ultrasound and MRI in diagnosis of simple fetal indirect hernia.MethodsA total of 671 558 fetuses were examined in maternal and child healthcare hospital of Hubei from February 2003 to February 2015. Once inguinal hernia or testicular tumors was suspected, MRI examination was performed after prenatal ultrasound. Final diagnosis was confirmed by postnatal follow-up. The ultrasonographic characteristics of fetal indirect hernia were compared with prenatal MR image characteristics and postnatal follow-up results.ResultsThree cases were conifrmed after birth. The simple fetal indirect hernia was uncommon clinical entity which occurred during 3rd trimester. The ultrasonic characteristics in prenatal period were: (1) Right enlarged scrotum was iflled with heterogeneous lesion; intestinal peristalsis within the scrotum was found in real-time ultrasonography. (2) The contralateral testis in left scrotum and penis could be found. MRI could display the characteristicsof indirecthernia contents and its extension from abdominal cavity intoinguinalregion, which may help diagnose fetal simple indirect hernia. One case of fetal indirect hernia was misdiagnosed as testicular tumors, which was correctly diagnosed by MRI.ConclusionsThe simple fetal indirect hernia can be prenatally diagnosed by characteristic ultrasonic features, which can present with abnormal mass ininguinalregion. Prenatal ultrasound is the primary screening method of fetal indirect hernia. MRI can serve as a supplement approach. The combination of US and MRI can further improve the diagnostic accuracy of fetal indirect hernia.%目的:探讨超声与磁共振成像在胎儿腹股沟斜疝诊断中的临床应用价值。方法对2003年2月至2015年2月在湖北省妇幼保健院产前超声检查的671558例胎儿行系统超声检查,并对超声检出腹股沟斜疝和疑诊睾丸肿瘤的胎儿行磁共振成像(MRI)和出生后超声复查。与出生后

  18. Prenatal Genetic Screening Tests

    Science.gov (United States)

    ... cells from the fetus or placenta obtained through amniocentesis or chorionic villus sampling (CVS) . FAQ164 “Prenatal Genetic ... should be followed by a diagnostic test with amniocentesis or CVS. The cell-free DNA screening test ...

  19. [Confrontation between ultrasound and fetopathological examination following therapeutic abortion performed in a maternity clinic in Tunisia].

    Science.gov (United States)

    Kehila, Mehdi; Halouani, Ahmed; Touhami, Omar; Abouda, Hassine Saber; Khlifi, Abdeljalil; Hmid, Rim Ben; Benhassen, Ines; Masmoudi, Aida; Chanoufi, Mohamed Badis

    2016-01-01

    This study aims to evaluate the value of prenatal ultrasound diagnosis by comparing it with the results of the fetopathological examination in case of therapeutic interruption of pregnancy for fetal indication. We conducted a retrospective descriptive and analytical study carried out over a three-year period from January 2013 to December 2015. It involved 66 fetuses autopsied after therapeutic interruption of pregnancy for fetal indication. Fetopathological examination confirmed ultrasound results in 63 cases (95.4%). In 18 cases (27.2%) there was a full match between the results of the prenatal diagnosis and those of the autopsy. Nine percent of fetal malformations were detected in the first trimester. The majority of malformations (72%) were detected in the second timester. Neurological malformations were the most frequent (60%), dominated by hydrocephalus and anencephaly. This study shows that, in our clinical context, even if ultrasound diagnosis is often non-exhaustive, its signs indicating the need for interruptions of pregnancy are correct. Fetopathological examination is used, in this case, to detect unknown malformations, making it possible to specify the diagnosis and to implement a strategy for subsequent pregnancies.

  20. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... ultrasound images are captured in real-time, they can show the structure and movement of the body's ... time, rather than as a color picture. It can also convert blood flow information into a distinctive ...

  1. Ovarian cysts on prenatal MRI

    Energy Technology Data Exchange (ETDEWEB)

    Nemec, Ursula [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Nemec, Stefan F., E-mail: stefan.nemec@meduniwien.ac.at [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, CA 90048 (United States); Bettelheim, Dieter [Department of Obstetrics and Gynaecology, Division of Prenatal Diagnosis and Therapy, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Brugger, Peter C. [Center of Anatomy and Cell Biology, Integrative Morphology Group, Medical University Vienna, Waehringerstrasse 13, A-1090 Vienna (Austria); Horcher, Ernst [Department of Pediatric Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Schoepf, Veronika [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Graham, John M.; Rimoin, David L. [Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, CA 90048 (United States); Weber, Michael; Prayer, Daniela [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria)

    2012-08-15

    Objective: Ovarian cysts are the most frequently encountered intra-abdominal masses in females in utero. They may, at times, require perinatal intervention. Using magnetic resonance imaging (MRI) as an adjunct to ultrasonography (US) in prenatal diagnosis, we sought to demonstrate the ability to visualize ovarian cysts on prenatal MRI. Materials and methods: This retrospective study included 17 fetal MRI scans from 16 female fetuses (23-37 gestational weeks) with an MRI diagnosis of ovarian cysts after suspicious US findings. A multiplanar MRI protocol was applied to image and to characterize the cysts. The US and MRI findings were compared, and the prenatal findings were compared with postnatal imaging findings or histopathology. Results: Simple ovarian cysts were found in 10/16 cases and complex cysts in 7/16 cases, including one case with both. In 11/16 (69%) cases, US and MRI diagnoses were in agreement, and, in 5/16 (31%) cases, MRI specified or expanded the US diagnosis. In 6/16 cases, postnatal US showed that the cysts spontaneously resolved or decreased in size, and in 1/16 cases, postnatal imaging confirmed a hemorrhagic cyst. In 4/16 cases, the prenatal diagnoses were confirmed by surgery/histopathology, and for the rest, postnatal correlation was not available. Conclusion: Our results illustrate the MRI visualization of ovarian cysts in utero. In most cases, MRI will confirm the US diagnosis. In certain cases, MRI may provide further diagnostic information, additional to US, which is the standard technique for diagnosis, monitoring, and treatment planning.

  2. Fetal Ultrasound

    Science.gov (United States)

    ... needle placement during certain prenatal tests, such as amniocentesis or chorionic villus sampling. Determine fetal position before ... home. Accessed Aug. 11, 2015. Ghidini A. Diagnostic amniocentesis. http://www.uptodate.com/home. Accessed Aug. 11, ...

  3. [Cystic adenomatoid malformation of the lung. Importance of prenatal diagnosis].

    Science.gov (United States)

    Cabeza, Beatriz; Oñoro, Gonzalo; Cantarín Extremera, Verónica; Sanz Santiago, Verónica; Sequeiros, Adolfo

    2011-04-01

    Cystic adenomatoid malformation of the lung is a rare malformation of the lung airway which often performed diagnosed in the prenatal period by ultrasound. Ultrasound monitoring should be performed during pregnancy to assess lung development. We report the case of a 4-year-old patient with prenatal diagnosis of cystic adenomatoid malformation of the lung, not confirmed by chest radiograph at birth. The patient underwent surgery at 4 years of age after diagnosis was made for presenting recurrent pneumonia. A normal chest radiograph at birth does not exclude this malformation and a computerized tomography at 4 weeks of birth must be done to confirm or rule out this anomaly. Once the diagnosis is made, surgical treatment should be prompted to avoid complications.

  4. A case of prenatally diagnosed partial monosomy 13q syndrome

    Directory of Open Access Journals (Sweden)

    Serenat Eris Yalcin

    2017-03-01

    Full Text Available Partial deletion of the long arm of chromosome 13 is a rare chromosomal aberration which is related to mental retardation, growth restriction and various congenital malformations. Central nervous system, cardiac, genitourinary, skeletal malformations and craniofacial dysmorphism can be observed. Prenatal diagnosis is possible by karyotyping and early genetic sonogram. Prenatal diagnosis can be difficult in cases that are not accompanied by major malformations but mental retardation and developmental delay in the forefront. In this report we aimed to present a case diagnosed 13-q syndrome prenatally as a result of karyotyping done due to multiple abnormal ultrasound findings in 14 weeks of pregnancy. [Cukurova Med J 2017; 42(1.000: 189-191

  5. Prenatal diagnosis--principles of diagnostic procedures and genetic counseling.

    Directory of Open Access Journals (Sweden)

    Ryszard Slezak

    2008-04-01

    Full Text Available The frequency of inherited malformations as well as genetic disorders in newborns account for around 3-5%. These frequency is much higher in early stages of pregnancy, because serious malformations and genetic disorders usually lead to spontaneous abortion. Prenatal diagnosis allowed identification of malformations and/or some genetic syndromes in fetuses during the first trimester of pregnancy. Thereafter, taking into account the severity of the disorders the decision should be taken in regard of subsequent course of the pregnancy taking into account a possibilities of treatment, parent's acceptation of a handicapped child but also, in some cases the possibility of termination of the pregnancy. In prenatal testing, both screening and diagnostic procedures are included. Screening procedures such as first and second trimester biochemical and/or ultrasound screening, first trimester combined ultrasound/biochemical screening and integrated screening should be widely offered to pregnant women. However, interpretation of screening results requires awareness of both sensitivity and predictive value of these procedures. In prenatal diagnosis ultrasound/MRI searching as well as genetic procedures are offered to pregnant women. A variety of approaches for genetic prenatal analyses are now available, including preimplantation diagnosis, chorion villi sampling, amniocentesis, fetal blood sampling as well as promising experimental procedures (e.g. fetal cell and DNA isolation from maternal blood. An incredible progress in genetic methods opened new possibilities for valuable genetic diagnosis. Although karyotyping is widely accepted as golden standard, the discussion is ongoing throughout Europe concerning shifting to new genetic techniques which allow obtaining rapid results in prenatal diagnosis of aneuploidy (e.g. RAPID-FISH, MLPA, quantitative PCR.

  6. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination : An analysis of 709,030 births in 12 European countries

    NARCIS (Netherlands)

    Wiesel, A; Queisser-Luft, A; Clementi, M; Bianca, S; Stoll, C

    2005-01-01

    The study was performed to evaluate the prevalence of prenatal ultrasound diagnoses for renal anomalies in 20 registries of 12 European countries, and to compare the different prenatal scanning policies. Standardized data were acquired from 709,030 livebirths, stillbirths, and induced abortions duri

  7. Thyroid ultrasound

    OpenAIRE

    Vikas Chaudhary; Shahina Bano

    2013-01-01

    Thyroid ultrasonography has established itself as a popular and useful tool in the evaluation and management of thyroid disorders. Advanced ultrasound techniques in thyroid imaging have not only fascinated the radiologists but also attracted the surgeons and endocrinologists who are using these techniques in their daily clinical and operative practice. This review provides an overview of indications for ultrasound in various thyroid diseases, describes characteristic ultrasound findings in th...

  8. Ultrasound physics.

    Science.gov (United States)

    Shriki, Jesse

    2014-01-01

    Bedside ultrasound has become an important modality for obtaining critical information in the acute care of patients. It is important to understand the physics of ultrasound in order to perform and interpret images at the bedside. The physics of both continuous wave and pulsed wave sound underlies diagnostic ultrasound. The instrumentation, including transducers and image processing, is important in the acquisition of appropriate sonographic images. Understanding how these concepts interplay with each other enables practitioners to obtain the best possible images.

  9. Fetal Neurosonogaphy: Ultrasound and Magnetic Resonance Imaging in Competition.

    Science.gov (United States)

    Tercanli, S; Prüfer, F

    2016-12-01

    Both in routine diagnostics and detailed, highly specialized workups, major advances have been observed in many areas of ultrasound due to an increase in expertise and improved technology in recent years. This is particularly true in the case of fetal neurosonography 1 2 3 4. Malformations of the CNS together with fetal heart defects are among the most common congenital anomalies. From the embryonic phase to the late third trimester, the CNS undergoes extensive development and maturation processes. The diagnosis of CNS anomalies is therefore primarily dependent on the time at which the examination is performed and the experience of the examiner. The introduction of transvaginal and 3 D ultrasound for evaluating fetal brain structures has made it possible to diagnose pathological findings of the CNS with increasing accuracy 5. The detection rates for CNS anomalies are up to 90 - 95 % depending on the finding 3 5. Today, detailed fetal neurosonography also includes differential diagnostic evaluation of the posterior cranial fossa, the corpus callosum (CC), and the gyri and therefore exceeds the primarily conspicuous, non-specific diagnosis of "ventricular dilation" often occurring as an accompanying symptom 6 7 The article "Prenatal Diagnosis of Corpus Callosum Anomalies" appearing in this issue shows an increase in the frequency of diagnosis and also shows that it is possible to differentiate between complete and partial corpus callosum agenesis and hypoplasia of the corpus callosum with differentiation between isolated and non-isolated cases is possible on ultrasound. In 4 of 44 cases in which both neurosonography and intrauterine MRI were performed, there was a discrepancy between the ultrasound diagnosis and the intrauterine MRI findings. In a comparison of the sonographic diagnoses and the MRI findings, additional pathologies were seen on MRI but not on ultrasound in only 3 of 44 cases. In a further case of CC hypoplasia, the sonographic diagnosis was

  10. Prenatal psychosocial risk assessment using event history calendars with Black women.

    Science.gov (United States)

    Munro, Michelle L; Dahlem, Chin Hwa Y; Lori, Jody R; Martyn, Kristy K

    2012-01-01

    To explore the clinical acceptability and perceptions of use of a prenatal event history calendar (EHC) for prenatal psychosocial risk assessment in Black pregnant women. A qualitative descriptive study focused on interviews and prenatal EHCs completed by Black pregnant women. Inner city hospital prenatal care clinic in Southeastern Michigan. Thirty 18-35 year old pregnant Black women receiving prenatal care at the participating clinic. Women completed the prenatal EHCs and their perceptions of its use were obtained through face to face interviews. The constant comparative method of analysis (Glaser, 1978, 1992) revealed themes from participants' descriptions about use of a prenatal EHC for prenatal psychosocial risk assessment. Three main themes emerged describing how the prenatal EHC enhanced communication. The prenatal EHC provided "an opening" for disclosure, "an understanding with you," and a way for providers to "know you, your life, and future plans." The participants' completed prenatal EHCs included information regarding their pre-pregnancies, trimester histories, and future plans. These completed prenatal EHCs showed patterns of change in life events and behaviors that included worries, stressors, and risk behaviors. The participants perceived the prenatal EHC as an easy to use tool that should be used to improve communication with health care providers. The prenatal EHC allows the patient and provider to "start on the same page" and provides an additional avenue for discussion of sensitive psychosocial issues with Black pregnant women. As a clinical tool, the prenatal EHC facilitated patient-provider communication for pregnant women often marked by health disparities. The prenatal EHC is a clinically acceptable tool to assess for psychosocial risk factors of Black women in a prenatal clinical setting. © 2012 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

  11. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... medical test that helps physicians diagnose and treat medical conditions. There are three types of pelvic ultrasound: abdominal ( transabdominal ) vaginal ( transvaginal / endovaginal ) ...

  12. Carotid Ultrasound Imaging

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Carotid Carotid ultrasound uses sound waves to produce ... limitations of Carotid Ultrasound Imaging? What is Carotid Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  13. General Ultrasound Imaging

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures ... limitations of General Ultrasound Imaging? What is General Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  14. Venous Ultrasound (Extremities)

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Venous (Extremities) Venous ultrasound uses sound waves to ... limitations of Venous Ultrasound Imaging? What is Venous Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  15. Your First Prenatal Care Checkup

    Science.gov (United States)

    ... report card Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ... Last reviewed: May, 2011 Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal care Is it safe? Labor & ...

  16. Prenatal Care: Third Trimester Visits

    Science.gov (United States)

    Healthy Lifestyle Pregnancy week by week During the third trimester, prenatal care might include vaginal exams to check the baby's ... 2015 Original article: http://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/prenatal-care/art- ...

  17. Prenatal Care: Second Trimester Visits

    Science.gov (United States)

    Healthy Lifestyle Pregnancy week by week During the second trimester, prenatal care includes routine lab tests and measurements of your ... 2015 Original article: http://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/prenatal-care/art- ...

  18. Avaliação da frequência de realização do exame físico das mamas, da colpocitologia cervical e da ultrassonografia obstétrica durante a assistência pré-natal: uma inversão de valores Evaluation of the frequency of accomplishment of the breast examination and of oncotic cervical cytology and the obstetrical ultrasound during the prenatal period: an inversion of values

    Directory of Open Access Journals (Sweden)

    Carla Vitola Gonçalves

    2009-01-01

    Full Text Available INTRODUÇÃO: Embora o exame de ultrassonografia seja um procedimento frequente na gravidez, o seu uso rotineiro não demonstrou efetividade sobre a redução da morbi-mortalidade materna ou perinatal. OBJETIVOS: Avaliar a cobertura do exame das mamas e da citologia oncótica cervical entre os exames de pré-natal, comparando-se com o número de ultrassonografias obstétricas realizadas. MÉTODOS: Constituiu-se de uma avaliação transversal, realizada na cidade de Rio Grande (RS, entre maio e julho de 2007. Os dados obtidos por meio de um questionário estruturado foram digitados no programa Epi-Info 6.04 e analisados no software SPSS. RESULTADOS: Entre as 230 puérperas entrevistadas, 99,1% realizaram ultrassonografia durante a gravidez, enquanto 37,5% e 33,6% realizaram exame clínico das mamas ou colpocitologia cervical, respectivamente. Houve significância estatística (p-valor Although ultrasound examination is a frequent procedure during pregnancy, routine use has not been effective to reduce maternal or perinatal morbidity-mortality. OBJECTIVE: Assess frequency of breast examination and of oncotic cervical cytology among prenatal exams and compare it to frequency of obstetrical ultrasound. METHODS: This was a cross-sectional evaluation conducted in the city of Rio Grande, RS, Brazil between May and July 2007. Data obtained with a structured questionnaire were entered into the Epi-Info 6.04 program and analyzed using the SPSS software. RESULTS: Among the 230 puerperae interviewed, 99.1% had undergone an ultrasound during pregnancy, while 37.5% and 33.6% had been submitted to clinical examination of the breasts and cervical cytology, respectively. It was noted that a larger number of obstetrical echographies increased the probability that a patient would be submitted to clinical examination of the breasts. On the other hand, the number of cytopathological evaluations of the uterine cervix was not influenced by the number of ultrasound

  19. Prenatal Genetic Testing Chart

    Science.gov (United States)

    ... NT ultrasound exam • Screens for Down • syndrome and trisomy 18 First-trimester screening Second-trimester screening (“quad ... 22 weeks • Blood test • Screens for Down syndrome, trisomy 13, trisomy 18, and NTDs Standard ultrasound exam • ...

  20. Infección prenatal

    OpenAIRE

    Pastor Durán, Xavier

    1986-01-01

    Protocolos terapeuticos. Infección prenatal. Riesgo de infección prenatal. La infección prenatal requiere un alto índice de sospecha, ya que no siempre, los antecedentes se hallan presentes bien porque faltan o bien porque hayan pasado desapercibidos. Dentro del concepto de infección prenatal se encuentran las englobadas en el acrónimo Torches (toxoplasmosis, rubeola, citomegalovirosis, herpes o sífilis) )...

  1. Prenatal diagnosis of isolated interrupted inferior vena cava with azygos continuation to superior vena cava

    Directory of Open Access Journals (Sweden)

    Do Thi Cam Giang

    2014-01-01

    Full Text Available Absence of inferior vena cava is an uncommon congenital abnormality. It is usually associated with other structural anomalies, typically left isomerism. We report a case of interrupted inferior vena cava with azygos continuation diagnosed as an isolated finding during routine prenatal ultrasound scan, confirmed by post-natal echocardiography. Detailed ultrasound examination of the fetal anatomy failed to demonstrate other anomalies. The neonatal course of this fetus was uneventful.

  2. Ultrasound transmission attenuation tomography using energy-scaled amplitude ratios

    Science.gov (United States)

    Chen, Ting; Shin, Junseob; Huang, Lianjie

    2016-04-01

    Ultrasound attenuation of breast tumors is related to their types and pathological states, and can be used to detect and characterize breast cancer. Particularly, ultrasound scattering attenuation can infer the margin properties of breast tumors. Ultrasound attenuation tomography quantitatively reconstructs the attenuation properties of the breast. Our synthetic-aperture breast ultrasound tomography system with two parallel transducer arrays records both ultrasound reflection and transmission signals. We develop an ultrasound attenuation tomography method using ultrasound energy-scaled amplitude decays of ultrasound transmission signals and conduct ultrasound attenuation tomography using a known sound-speed model. We apply our ultrasound transmission attenuation tomography method to a breast phantom dataset, and compare the ultrasound attenuation tomography results with conventional beamforming ultrasound images obtained using reflection signals. We show that ultrasound transmission attenuation tomography complements beamforming images in identifying breast lesions.

  3. 产前超声诊断胎儿肺部异常及预后评估%Prenatal Diagnosis of Fetal Congenital Disease of Lung and Clinical Prognosis by Ultrasound

    Institute of Scientific and Technical Information of China (English)

    陆冰; 姜小力; 殷林亮; 邓学东

    2015-01-01

    Objective To describe the antenatalfi ndings and outcome of fetuses with congenital lung disease. MethodsA total of 147 cases of fetal congenital disease of lung were diagnosed and the data was retrospectively analyzed.Results 1. Among the 147 fetuses of congenital lung disease, there were 89 lung lesion; 59 cases of pleural effusion (PE), 4 case of echogenic lung; 1 case of pulmonary hypopasia with ribs malformation and 1 case of pulmonary agenesis (PA); 2. 49 patients with other pulmonary abnormalities, including: fetal edema, lymph hydroma, congenital heart malformation, skeletal deformities, hepatic cyst, heart shift, Bilateral hydronephrosis, single umbilical artery and amnioticfl uid; 3. Fetal outcome: a total of 97 cases of fetus performed induced abortion, 10 cases of disease spontaneous regression before labor, 40 cases of lesions persist and choose to continue pregnancy.ConclusionPrenatal ultrasonography has a high accuracy rate for the diagnosis and classification of fetal congenital lung disease. For different types of pulmonary lesions need to be carefully identifi ed. With detailed observation of the fetus and prenatal follow-up, ultrasonography is helpful to predict the clinical outcome of the fetus.%目的:探讨胎儿肺部异常的产前超声特征及评估临床预后价值。方法对147例产前超声诊断有胎儿肺部异常的胎儿声像图进行回顾性分析。结果①147例肺部异常的胎儿中产前检出89例团块样病变;检出胸腔积液共59例,检出4例肺回声弥漫性增强;1例肺发育不良伴有肋骨畸形;1例肺缺如。②49例伴发其他肺部异常,包括:胎儿水肿、淋巴水囊瘤、心脏畸形、骨骼畸形、肝囊肿、心脏移位、双肾积水、单脐动脉、羊水过多;③胎儿临床结局:147例共有97例胎儿选择引产,10例病变产前自行消退,40例病灶持续存在并选择继续妊娠。结论对于肺部病灶的不同类型诊断需要谨慎鉴别,

  4. Prostate Ultrasound

    Medline Plus

    Full Text Available ... Español More Info Images/Videos About Us News Physician Resources Professions Site Index A-Z Ultrasound - Prostate ... imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. Prostate ultrasound, also ...

  5. Clinical Value of Ultrasound on the Prenatal Diagnosis of Fetal Malformation in Middle and Late Pregnancy%为孕妇进行中晚孕期胎儿畸形筛查的临床意义

    Institute of Scientific and Technical Information of China (English)

    尤艳

    2015-01-01

    Objective: To analyze the value of ultrasound technology on the diagnosis of the fetal malformation for women at the middle and late pregnancy. Methods: 800 cases who were diagnosed by ultrasound in early pregnancy in our hospital from June 2010 to June 2014 were chosen. Subsequent ultrasounds were performed in middle pregnancy (from 20~24 weeks) and late pregnancy (from 29~32 weeks) separately, in which the diagnosis and misdiagnosis rate were calculated. Results: 14 fetal malformation cases were detected, the rate of detection was 1.75% . 11 cases were detected in middle pregnancy. 3 cases were misdiagnosed in middle pregnancy. Conclusion: Ultrasonography has great value in diagnosing fetal malformation, it has high detect value. However, some deformities do not appear obviously in middle pregnancy,we should pay more attention to fetal face,head and heart in late pregnancy in order to decrease missed diagnosis.%目的:分析为孕妇进行中晚孕期胎儿畸形筛查的临床意义。方法:将2010年6月至2014年6月我院收治的800例在早孕期(孕龄10~12周)经彩色多普勒超声检查证实胎儿正常的孕妇作为研究对象,分别在其中孕期(孕龄20~24周)、晚孕期(孕龄29~32周)再次为其进行彩色多普勒超声胎儿畸形筛查,并分析其胎儿畸形的检出率及漏诊率。结果:在本组800例孕妇中,有14例孕妇被检出胎儿畸形,检出率为1.75%(14/800),其中有11例中孕期胎儿,有3例晚孕期胎儿。在本组孕妇中,有3例孕妇的中孕期畸形胎儿被漏诊,漏诊率为21.43%。结论:进行彩色多普勒超声检查是诊断胎儿先天性发育畸形的重要方法。部分胎儿畸形在进行中孕期超声检查时表现不典型。在为孕妇进行晚孕期超声检查时应注意对其胎儿的颜面部、胸部、四肢等部位进行扫描,以提高胎儿畸形的检出率,降低其漏诊率。

  6. Comparison of prenatal ultrasound screening results and fetal health status of twin pregnancy and twin pregnancy in assisted reproductive technology%辅助生殖技术受孕双胎与自然受孕双胎的产前超声筛查结果及胎儿的健康状况比较观察

    Institute of Scientific and Technical Information of China (English)

    蒋华景; 郭津含; 陈静; 林丽璇; 熊剑

    2016-01-01

    Objective To compare the prenatal ultrasound screening results and fetal health status of twin pregnancy and twin pregnancy in assisted reproductive technology (ART). Methods 90 cases of pregnant women with twin pregnancy after ART from January 2011 to June 2015 were selected as observation group, 100 cases of spontaneous twin pregnant women were selected as control group. The relevant data of prenatal ultrasound examination and fetal situation were collected, and pregnancy outcome of the two groups were compared. Results Polyhydramnios, umbilical cord around the neck, the incidence of premature rupture of membranes rate, placenta previa incidence, anemia rate and postpartum hemorrhage incidence of the two groups had no significant difference (P 0.05). Twin transfusion syndrome incidence of observation group was significantly lower than that of control group (P 0.05). The average body weight of observation group was significantly higher than that of control group (P <0.05). Conclusion ART twin pregnancy does not increase the risk of perinatal complications. Compared to natural pregnancy, it has obvious advantages on amniotic fluid abnormalities, changes in the umbilical cord and the twin transfusion syndrome.%目的:比较辅助生殖技术受孕双胎与自然受孕双胎的产前超声筛查结果及胎儿的健康状况。方法选取2011年1月~2015年6月期间在我院应用辅助生殖技术(ART)怀孕双胎90例孕妇设为观察组,及同期自然受孕双胎100例孕妇为参照组,收集产前超声检测得到的相关数据以及胎儿情况,对比分析并比较两组的妊娠结局。结果两组在羊水过多、脐带绕颈发生率、胎膜早破发生率、前置胎盘发生率、贫血发生率和产后出血发生率等方面比较无显著差异(P<0.05);观察组平均羊水量显著多于参照组,羊水过少、脐带附着位置变化发生率显著低于参照组(P<0.05)。两组患者胎儿畸形率、

  7. Prenatal Programming and Toxicity (PPTOX) Introduction.

    Science.gov (United States)

    Birnbaum, Linda S; Miller, Mark F

    2015-10-01

    The developmental origin of health and disease hypothesis posits that early-life exposures, including prenatal, can influence disease outcomes throughout the entire lifespan of an organism. Over the past 30 years, scientific researchers have compiled robust epidemiological and mechanistic data showing the effects of early-life nutrition, chemical exposures, and stress on prenatal programing and toxicity. Using novel techniques in genomics and epigenetics, science is now establishing strong links between low-level early-life environmental exposures and the later development of noncommunicable diseases, such as cardiovascular disease, obesity, diabetes, neurodevelopmental and neurodegenerative disease, reproductive effects, immune system function and cancer. Now scientists must engage with communities, industry, policy makers, and clinicians to leverage our newfound understanding of prenatal programing and toxicity into better health outcomes across the lifespan.

  8. 产前高频超声检查在剖宫产瘢痕子宫胎盘植入的临床应用%Clinical application of high frequency prenatal ultrasound in the diagnosis of placenta increta in cesarean section scar uterine

    Institute of Scientific and Technical Information of China (English)

    樊树华

    2013-01-01

    Objective To investigate the prenatal ultrasonographic features of placenta increta in cesarean section scar uterus using high frequency color ultrasound, so as to increase the diagnostic accuracy of placenta increta. Methods Color ultrasonographic data of 32 cases of placenta increta in cesarean section scar uterus confirmed by pathology or clinical information were analyzed retrospectively. The data in our hospital were collected from October 2009 to May 2013.Results Of the 32 cases, 3 cases were false negative, so the diagnosis accuracy rate was 90.6%. Conclusion To grasp the ultrasonographic characteristics of placenta increta in cesarean section scar uterus can increase the detection rate.%目的:探讨剖宫产瘢痕子宫胎盘植入的产前高频彩超声像图特征,以提高产前超声检查瘢痕子宫胎盘植入的准确率。方法回顾性分析2009年10月~2013年5月在我院经产后病理或临床证实为瘢痕子宫胎盘植入的32例患者彩超资料。结果32例胎盘植入患者中,产前高频彩超诊断29例,漏诊3例,诊断准确率90.6%。结论准确掌握瘢痕子宫胎盘植入的产前高频超声声像图特点,能提高胎盘植入的检出率。

  9. Percutaneous ultrasound guided umbilical cord blood sampling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Hyup; Choi, B. I.; Kim, C. W.; Youn, B. H.; Shin, H. C.; Kim, S. O. [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1989-12-15

    This report describes a technique and the result of percutaneous ultrasound-guided umbilical cord blood sampling and its potential use in the management of diagnostic problems in the second and third trimester of pregnancy. This method has been employed in the prenatal assessment of 19 fetuses at risk for chromosomal disorders, fetal hypoxia and hematologic disorders. This simple and rapid procedure offers a safe access to the fetal circulation

  10. Prenatal stress alters amygdala functional connectivity in preterm neonates.

    Science.gov (United States)

    Scheinost, Dustin; Kwon, Soo Hyun; Lacadie, Cheryl; Sze, Gordon; Sinha, Rajita; Constable, R Todd; Ment, Laura R

    2016-01-01

    Exposure to prenatal and early-life stress results in alterations in neural connectivity and an increased risk for neuropsychiatric disorders. In particular, alterations in amygdala connectivity have emerged as a common effect across several recent studies. However, the impact of prenatal stress exposure on the functional organization of the amygdala has yet to be explored in the prematurely-born, a population at high risk for neuropsychiatric disorders. We test the hypothesis that preterm birth and prenatal exposure to maternal stress alter functional connectivity of the amygdala using two independent cohorts. The first cohort is used to establish the effects of preterm birth and consists of 12 very preterm neonates and 25 term controls, all without prenatal stress exposure. The second is analyzed to establish the effects of prenatal stress exposure and consists of 16 extremely preterm neonates with prenatal stress exposure and 10 extremely preterm neonates with no known prenatal stress exposure. Standard resting-state functional magnetic resonance imaging and seed connectivity methods are used. When compared to term controls, very preterm neonates show significantly reduced connectivity between the amygdala and the thalamus, the hypothalamus, the brainstem, and the insula (p cortex (p subcortical regions is decreased in preterm neonates compared to term controls. In addition, these data, for the first time, suggest that prenatal stress exposure amplifies these decreases.

  11. Determinants of the use of prenatal care in rural China: the role of care content.

    Science.gov (United States)

    Nwaru, Bright I; Wu, Zhuochun; Hemminki, Elina

    2012-01-01

    Several maternal demographic factors have been identified to influence the timing of starting prenatal care and its adequate use. However, how the content of prenatal care modifies these factors has not been studied previously. Using a representative sample collected for other purposes in rural China, we examined the factors predicting the uptake of prenatal care by taking into account the content of care (advice: on nutrition during pregnancy, diseases and pregnancy-related problems, and on child care after birth; and routine tests: blood pressure, blood tests, and ultrasound). We studied 1,479 women who answered a house-hold KAP (knowledge, attitude, and practice) survey (97% response rate) collected after a prenatal care intervention from 2001 to 2003 in 20 townships located in a county in Anhui Province. A multinomial logistic regression was used for the analysis. The most prominent factors that predicted late start of prenatal care and inadequate care were younger age, low maternal income, and having more than one child. When we adjusted for the content of care, the influence of these factors on the use of prenatal care attenuated to varying degrees: in some cases there was up to 20% reduction in the values of the risk estimates, while in other cases the statistical significance of the estimates were lost. It is important to take into account the content of prenatal care when assessing the factors predicting women's use of prenatal care.

  12. Cranial Ultrasound/Head Ultrasound

    Science.gov (United States)

    ... sickle cell disease. It is also used to measure conditions affecting blood flow to and within the brain, such as: Stenosis : ... saved. Doppler ultrasound, a special application of ultrasound, measures ... represent the flow of blood through the blood vessels. top of ...

  13. Diagnóstico prenatal del pie bot Prenatal diagnosis of clubfoot

    Directory of Open Access Journals (Sweden)

    Julio Javier Masquijo

    2011-12-01

    Full Text Available Introducción. El pie bot es una de las anomalías músculo- esqueléticas congénitas más frecuentes. La utilización de la ecografía para la detección prenatal del pie bot ha avanzado rápidamente en la última década, pero las publicaciones han presentado una gran variabilidad de opiniones en cuanto a la eficacia del método, la asociación con otras patologías y la necesidad de realizar amniocentesis para análisis del cariotipo. Objetivos. Analizar en qué porcentaje de pacientes se realizó diagnóstico prenatal del pie bot, evaluar la opinión de las madres al respecto y aclarar algunos conceptos revisando la bibliografía disponible a la fecha. Métodos. Se analizó retrospectivamente un grupo de 54 pacientes consecutivos con diagnóstico de pie bot tratados en el período enero 2008-junio 2010. Se documentaron el número de ecografías realizadas durante el embarazo, el tipo de ecografía realizada (2D, 3D o 4D y la semana de gestación al momento del diagnóstico. Las madres fueron encuestadas a fin de conocer su opinión con respecto al diagnóstico prenatal de esta deformidad. Resultados. Se realizaron 3,2 ecografías promedio durante el embarazo (r, 1-7. En el 25% (13/52 de los casos se realizó diagnóstico prenatal. El diagnóstico fue realizado en 7 casos con ecografía 2D, en 4 con 3D y en 2 con 4D, y en promedio se efectuó a la semana 22 (r, 20-28. En ningún paciente se llevó a cabo diagnóstico temprano, en 12 fue tardío y en 1 muy tardío. Conclusión. El diagnóstico prenatal permite a los padres de prepararse psicológicamente y asesorarse sobre la patología. En nuestra serie, el 90,4% se mostró a favor de conocer previamente el diagnóstico.Introduction. Clubfoot is one of the most frequent congenital musculoskeletal anomalies. The use of ultrasound for prenatal detection of clubfoot has advanced rapidly in the last decade, but publications report a great variability in opinions regarding the effectiveness of

  14. Prenatal findings and epimutations for paternal uniparental disomy for chromosome 14 syndrome.

    Science.gov (United States)

    Watanabe, Takafumi; Go, Hayato; Kagami, Masayo; Yasuda, Shun; Nomura, Yasuhisa; Fujimori, Keiya

    2015-07-01

    The phenotypes associated with paternal uniparental disomy for chromosome 14 (UPD(14)pat) are clinically distinctive and caused by genetic alterations at the 14q32.2 imprinted region. Here we describe prenatal and neonatal findings in a case of epimutation associated with UPD(14)pat-like phenotype. A 25-year-old Japanese woman was referred to hospital at 32 weeks of gestation for management of threatened premature delivery. Fetal ultrasound and magnetic resonance imaging showed a narrow thorax and polyhydramnios. At 35 weeks of gestation, emergency cesarean section was performed and placentomegaly was identified. Physical examination of the neonate indicated a small narrow thorax, diastasis recti, and dysmorphic facial features that included hirsute forehead, broad flat nasal bridge, micrognathia, small ears, and a long protruding philtrum. Genetic analysis identified epimutation at the intergenic differentially methylated region (IG-DMR) and at MEG3-DMR.

  15. The Importance of Multidisciplinary Management during Prenatal Care for Cleft Lip and Palate

    Science.gov (United States)

    Han, Hyun Ho; Choi, Eun Jeong; Kim, Ji Min; Shin, Jong Chul

    2016-01-01

    Background The prenatal ultrasound detection of cleft lip with or without cleft palate (CL/P) and its continuous management in the prenatal, perinatal, and postnatal periods using a multidisciplinary team approach can be beneficial for parents and their infants. In this report, we share our experiences with the prenatal detection of CL/P and the multidisciplinary management of this malformation in our institution's Congenital Disease Center. Methods The multidisciplinary team of the Congenital Disease Center for mothers of children with CL/P is composed of obstetricians, plastic and reconstructive surgeons, pediatricians, and psychiatrists. A total of 11 fetuses were diagnosed with CL/P from March 2009 to December 2013, and their mothers were referred to the Congenital Disease Center of our hospital. When CL/P is suspected in the prenatal ultrasound screening examination, the pregnant woman is referred to our center for further evaluation. Results The abortion rate was 28% (3/11). The concordance rate of the sonographic and final diagnoses was 100%. Ten women (91%) reported that they were satisfied with the multidisciplinary management in our center. Conclusions Although a child with a birth defect is unlikely to be received well, the women whose fetuses were diagnosed with CL/P on prenatal ultrasound screening and who underwent multidisciplinary team management were more likely to decide to continue their pregnancy. PMID:27019808

  16. The Importance of Multidisciplinary Management during Prenatal Care for Cleft Lip and Palate

    Directory of Open Access Journals (Sweden)

    Hyun Ho Han

    2016-03-01

    Full Text Available BackgroundThe prenatal ultrasound detection of cleft lip with or without cleft palate (CL/P and its continuous management in the prenatal, perinatal, and postnatal periods using a multidisciplinary team approach can be beneficial for parents and their infants. In this report, we share our experiences with the prenatal detection of CL/P and the multidisciplinary management of this malformation in our institution's Congenital Disease Center.MethodsThe multidisciplinary team of the Congenital Disease Center for mothers of children with CL/P is composed of obstetricians, plastic and reconstructive surgeons, pediatricians, and psychiatrists. A total of 11 fetuses were diagnosed with CL/P from March 2009 to December 2013, and their mothers were referred to the Congenital Disease Center of our hospital. When CL/P is suspected in the prenatal ultrasound screening examination, the pregnant woman is referred to our center for further evaluation.ResultsThe abortion rate was 28% (3/11. The concordance rate of the sonographic and final diagnoses was 100%. Ten women (91% reported that they were satisfied with the multidisciplinary management in our center.ConclusionsAlthough a child with a birth defect is unlikely to be received well, the women whose fetuses were diagnosed with CL/P on prenatal ultrasound screening and who underwent multidisciplinary team management were more likely to decide to continue their pregnancy.

  17. Prenatal stress in pigs

    NARCIS (Netherlands)

    Kranendonk, Godelieve

    2006-01-01

    Studies in many species, including humans, have demonstrated that stress during gestation can have long-term developmental, neuroendocrine, and behavioural effects on the offspring. Because pregnant sows can be subjected to regular stressful situations, it is relevant to study whether prenatal stres

  18. Prenatal stress in pigs

    NARCIS (Netherlands)

    Kranendonk, Godelieve

    2006-01-01

    Studies in many species, including humans, have demonstrated that stress during gestation can have long-term developmental, neuroendocrine, and behavioural effects on the offspring. Because pregnant sows can be subjected to regular stressful situations, it is relevant to study whether prenatal stres

  19. Male sexual development in utero: testicular descent on prenatal magnetic resonance imaging.

    Science.gov (United States)

    Nemec, S F; Nemec, U; Weber, M; Kasprian, G; Brugger, P C; Krestan, C R; Rotmensch, S; Rimoin, D L; Graham, J M; Prayer, D

    2011-12-01

    To visualize in utero male fetal testicular descent on magnetic resonance imaging (MRI) and to correlate it with gestational age. This retrospective study included 202 MRI examination results of 199 male fetuses (17-39 gestational weeks) with normal anatomy or minor congenital abnormalities, following suspicion of anomalies on prenatal ultrasound examination. Using a 1.5-Tesla unit, multiplanar T2-weighted sequences were applied using a standard protocol to image and identify the scrotal content. The relative frequencies of unilateral and bilateral testicular descent were calculated and correlated with gestational age. Between 17 and 25 gestational weeks, neither unilateral nor bilateral testicular descent was visualized on MRI. Testicular descent was first observed at 25 + 4 weeks, in 7.7% of cases. 12.5% of 27-week fetuses showed unilateral descent and 50% showed bilateral descent. Bilateral descent was observed in 95.7% of cases, on average, from 30 to 39 weeks. Our results chart the time course of testicular descent on prenatal MRI, which may be helpful in the identification of normal male sexual development and in the diagnosis of congenital abnormalities, including the early detection of cryptorchidism. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.

  20. [Ultrasound findings in rhabdomyolysis].

    Science.gov (United States)

    Carrillo-Esper, Raúl; Galván-Talamantes, Yazmin; Meza-Ayala, Cynthia Margarita; Cruz-Santana, Julio Alberto; Bonilla-Reséndiz, Luis Ignacio

    Rhabdomyolysis is defined as skeletal muscle necrosis. Ultrasound assessment has recently become a useful tool for the diagnosis and monitoring of muscle diseases, including rhabdomyolysis. A case is presented on the ultrasound findings in a patient with rhabdomyolysis. To highlight the importance of ultrasound as an essential part in the diagnosis in rhabdomyolysis, to describe the ultrasound findings, and review the literature. A 30 year-old with post-traumatic rhabdomyolysis of both thighs. Ultrasound was performed using a Philips Sparq model with a high-frequency linear transducer (5-10MHz), in low-dimensional scanning mode (2D), in longitudinal and transverse sections at the level of both thighs. The images obtained showed disorganisation of the orientation of the muscle fibres, ground glass image, thickening of the muscular fascia, and the presence of anechoic areas. Ultrasound is a useful tool in the evaluation of rhabdomyolysis. Copyright © 2015 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

  1. Two cases of pontocerebellar hypoplasia: ethical and prenatal diagnostic dilemma.

    Science.gov (United States)

    Ajibola, Ayodeji J; Netzloff, Michael; Samaraweera, Ranji; Omar, Said A

    2010-02-01

    We report the clinical characteristics and the outcome of two cases of pontocerebellar hypoplasia (PCH) in one family. The objective of this report is to describe the mode of presentation, discuss the clinical course, and address the dilemma of prenatal diagnosis and the prospects for genetic diagnosis for PCH. The first case is a 4-year-old boy in whom the diagnosis was made in the neonatal period. Despite extensive prenatal follow-up during the mother's subsequent pregnancy, prenatal diagnosis could not be made and a second affected child was born. Both siblings have severe developmental delay. The cases raise an important ethical dilemma about the most appropriate intervention if the mother of a child affected with PCH becomes pregnant. PCH is considered to have an autosomal-recessive mode of inheritance and a recurrence risk of 25% in each pregnancy. Until recently when genetic mutations in PCH types 2, 4, and 6 began to be identified, the lack of well-recognized genetic testing precluded experts from making clear recommendations. The best advice to these parents was difficult or elusive. With two children currently affected, should the parents terminate or continue with the latest pregnancy? Extensive monitoring with serial prenatal ultrasound failed in the previous pregnancy and resulted in the birth of the second affected child. It is evident that serial ultrasound scan may not be helpful in making the diagnosis prenatally. Therefore, other diagnostic modalities such as magnetic resonance imaging may be necessary and should be considered. With the identification of genetic basis or mutations in PCH types 2, 4, and 6 and possible development of commercial genetic testing for these types of PCH, reproductive decision or genetic testing during pregnancy should be recommended to affected families to enable informed choices. Thieme Medical Publishers.

  2. Acardiac Twin Presented as a Lower Extremity:Case Report with Serial Prenatal Ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Boem Ha; Park, Seong Jin; Lee, Hae Kyung; Hong, Hyeon Sook; Lee, Kwon Hae; Kim, Tae Hee [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

    2010-03-15

    An acardiac twin is one of the very rare anomalies that occurs in monochorionic twins and the incidence of this is about one out of 35,000 births. We present the serial prenatal ultrasound findings, along with the postnatal histologic correlation, of an acardiac twin that manifested as a single lower extremity

  3. Prenatal diagnosis of Meckel-Gruber syndrome in a pregnancy obtained with ICSI.

    Science.gov (United States)

    Celentano, Claudio; Prefumo, Federico; Liberati, Marco; Gallo, Giuseppina; Di Nisio, Quirino; Rotmensch, Sigfried

    2006-06-01

    The association of occipital encephalocele, cleft palate, postaxial polydactyly, polycystic kidneys, and hepatic cysts is well known as Meckel-Gruber syndrome (MGS). Nowadays, the diagnosis of MGS is usually performed prenatally by ultrasound findings. MGS was previously described following in vitro fertilization. We report a case of MGS diagnosed at 17 weeks in a pregnancy obtained with intra-cytoplasmic sperm injection (ICSI).

  4. WOMENS OPINIONS ON THE OFFER AND USE OF PRENATAL-DIAGNOSIS

    NARCIS (Netherlands)

    TYMSTRA, T; BAJEMA, C; BEEKHUIS, [No Value; MANTINGH, A

    1991-01-01

    We have studied the opinions and attitudes of women towards prenatal diagnosis (amniocentesis/chorionic villus sampling/ultrasound/serum AFP testing). A questionnaire was sent to 185 women who had had their first baby a few months before. The respondents have a strong positive attitude towards the d

  5. The effect in premature infants of prenatal corticosteroids on endogenous surfactant synthesis as measured with stable isotopes

    NARCIS (Netherlands)

    J.E.H. Bunt (Jan Erik); V.P. Carnielli (Virgilio); J.L.D. Wattimena (Josias); W.C.J. Hop (Wim); P.J.J. Sauer (Pieter); L.J.I. Zimmermann (Luc)

    2000-01-01

    textabstractMost in vitro studies show that prenatal administration of corticosteroids stimulates the synthesis of surfactant phosphatidylcholine (PC), but studies in animals are controversial. Whether prenatal corticosteroids stimulate surfactant PC synthesis in humans

  6. The Impact of Ultrasound on Developing Brain Neurons. Science Briefs

    Science.gov (United States)

    National Scientific Council on the Developing Child, 2007

    2007-01-01

    "Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This brief reports on the study. This Brief summarizes the findings and implications of "Prenatal Exposure to Ultrasound Waves Impacts Neuronal Migration in Mice" (E. S. B. C. Ang, Jr.; V. Gluncic; A. Duque; M. E. Schafer; and P.…

  7. Ultrasound -- Pelvis

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  8. Prostate Ultrasound

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    Full Text Available ... areas of the body while other areas, especially air-filled lungs, are poorly suited for ultrasound. For ... appearance, size or contour of organs, tissues, and vessels or to detect abnormal masses, such as tumors. ...

  10. Prostate Ultrasound

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    Full Text Available ... the prostate is enlarged, also known as benign prostatic hyperplasia (BPH) , with measurements acquired as needed for any ... size with caption Related Articles and Media Benign Prostatic Hyperplasia (BPH) Prostate Cancer Ultrasound- and MRI-Guided Prostate ...

  11. Ultrasound -- Pelvis

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    Full Text Available ... ovaries. Transvaginal ultrasound also evaluates the myometrium (muscular walls of the uterus). Sonohysterography allows for a more ... needle insertion) is usually minimal because the rectal wall is relatively insensitive to the pain in the ...

  12. Prostate Ultrasound

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  13. Ultrasound -- Pelvis

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  14. Prostate Ultrasound

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  15. Ultrasound -- Pelvis

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    ... help diagnose symptoms experienced by women such as: pelvic pain abnormal bleeding other menstrual problems and help identify: ... children, pelvic ultrasound can help evaluate: pelvic masses pelvic pain ambiguous genitalia and anomalies of pelvic organs early ...

  16. Prostate Ultrasound

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    Full Text Available ... the returning echoes from the tissues in the body. The principles are similar to sonar used by boats and submarines. The ultrasound image is immediately visible on a video display screen ...

  17. Ultrasound -- Pelvis

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  18. Ultrasound -- Pelvis

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  19. Prostate Ultrasound

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  20. Ultrasound -- Pelvis

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  1. Prostate Ultrasound

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    Full Text Available ... patient consultation. View full size with caption Related Articles and Media Benign Prostatic Hyperplasia (BPH) (Enlargement of the Prostate) Prostate Cancer Ultrasound- and MRI-Guided Prostate Biopsy Images related ...

  2. Ultrasound -- Pelvis

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    Full Text Available ... ovarian cysts and uterine fibroids ovarian or uterine cancers A transvaginal ultrasound is usually performed to view ... detect: uterine anomalies uterine scars endometrial polyps fibroids cancer, especially in patients with abnormal uterine bleeding Some ...

  3. Prostate Ultrasound

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    Full Text Available ... use of a small transducer (probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the probe through the gel into the body. The transducer collects the sounds ...

  4. Ultrasound -- Pelvis

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  5. Ultrasound -- Pelvis

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  6. Prostate Ultrasound

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  7. Ultrasound -- Pelvis

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  8. Ultrasound -- Pelvis

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  9. Prostate Ultrasound

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  10. Ultrasound -- Pelvis

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  11. Prostate Ultrasound

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  12. Prostate Ultrasound

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    Full Text Available ... of page How is the procedure performed? In men, the prostate gland is located directly in front ... What are the limitations of Prostate Ultrasound Imaging? Men who have had the tail end of their ...

  13. Prostate Ultrasound

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    ... prostate. help diagnose the cause of a man's infertility. A transrectal ultrasound of the prostate gland is ... the transducer is pressed against the skin, it directs small pulses of inaudible, high-frequency sound waves ...

  14. Prostate Ultrasound

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  15. Ultrasound -- Pelvis

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  17. Prostate Ultrasound

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  18. Ultrasound -- Pelvis

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  19. Ultrasound -- Pelvis

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  20. Ultrasound -- Pelvis

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  1. Prostate Ultrasound

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  2. Ultrasound -- Pelvis

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  4. Prostate Ultrasound

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  5. Ultrasound -- Pelvis

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  6. Ultrasound -- Pelvis

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  7. Ultrasound -- Pelvis

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    Full Text Available ... are also used to monitor the health and development of an embryo or fetus during pregnancy. See ... I prepare? You should wear comfortable, loose-fitting clothing for your ultrasound exam. You may need to ...

  8. Ultrasound -- Pelvis

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    Full Text Available ... also used to guide procedures such as needle biopsies , in which needles are used to extract a ... gynecologic examination. For a transrectal exam: If no biopsy is required, transrectal ultrasound of the prostate is ...

  9. Ultrasound -- Pelvis

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    Full Text Available ... ultrasound exam room may have a television. Feel free to ask for your child's favorite channel. top ... be turned to either side to improve the quality of the images. After you are positioned on ...

  10. Ultrasound -- Pelvis

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    Full Text Available ... probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the ... small amount of gel is put on the skin to allow the sound waves to best travel ...

  11. Prostate Ultrasound

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    Full Text Available ... probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the ... small amount of gel is put on the skin to allow the sound waves to best travel ...

  12. Ultrasound -- Pelvis

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    Full Text Available ... extract a sample of cells from organs for laboratory testing. Doppler ultrasound images can help the physician ... the returning sound waves), as well as the type of body structure and composition of body tissue ...

  13. Hip Ultrasound

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    ... be used in infants to check for developmental dysplasia of the hip. Ultrasound is safe, noninvasive, and does not use ... be used to check the hips for developmental dysplasia of the hip (DDH), which in infants can range from a ...

  14. Ultrasound -- Pelvis

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    Full Text Available ... called color Doppler ultrasonography, is a special ultrasound technique that allows the physician to see and evaluate ... evaluation with additional views or a special imaging technique. A follow-up examination may also be necessary ...

  15. Ultrasound -- Pelvis

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    Full Text Available ... are obtained from different orientations to get the best views of the uterus and ovaries. Transvaginal ultrasound ... over time. Follow-up examinations are sometimes the best way to see if treatment is working or ...

  16. Ultrasound -- Pelvis

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    Full Text Available ... probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the ... the transducer (the device placed on the patient's skin to send and receive the returning sound waves), ...

  17. Prostate Ultrasound

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    Full Text Available ... probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the ... the transducer (the device placed on the patient's skin to send and receive the returning sound waves), ...

  18. Ultrasound -- Pelvis

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    Full Text Available ... or sonography , involves the use of a small transducer (probe) and ultrasound gel placed directly on the ... probe through the gel into the body. The transducer collects the sounds that bounce back and a ...

  19. Ultrasound -- Pelvis

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    Full Text Available ... insertion. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... requested the exam. Usually, the referring physician or health care provider will share the results with you. ...

  20. Prostate Ultrasound

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    Full Text Available ... gel. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... requested the exam. Usually, the referring physician or health care provider will share the results with you. ...

  1. Ultrasound -- Pelvis

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    Full Text Available ... Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown. ... I prepare? You should wear comfortable, loose-fitting clothing for your ultrasound exam. You may need to ...

  2. Prostate Ultrasound

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    Full Text Available ... Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown ... I prepare? You should wear comfortable, loose-fitting clothing for your ultrasound exam. You may need to ...

  3. Prostate Ultrasound

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    Full Text Available ... gel. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... these links. About Us | Contact Us | FAQ | Privacy | Terms of Use | Links | Site Map Copyright © 2017 Radiological ...

  4. Ultrasound -- Pelvis

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    Full Text Available ... insertion. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... these links. About Us | Contact Us | FAQ | Privacy | Terms of Use | Links | Site Map Copyright © 2017 Radiological ...

  5. Prostate Ultrasound

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    Full Text Available ... physician during a routine physical exam or prostate cancer screening exam. an elevated blood test result. difficulty urinating. Because ultrasound provides real-time images, it also can be used to guide ...

  6. Ultrasound -- Pelvis

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    Full Text Available ... in the abdomen, arms, legs, neck and/or brain (in infants and children) or within various body organs ... or uterine cancers A transvaginal ultrasound is usually performed to view ...

  7. Prostate Ultrasound

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    Full Text Available ... uses sound waves to produce pictures of a man’s prostate gland and to help diagnose symptoms such ... also called transrectal ultrasound, provides images of a man's prostate gland and surrounding tissue. The exam typically ...

  8. Prostate Ultrasound

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    Full Text Available ... a nodule found during a rectal exam, detect abnormalities, and determine whether the gland is enlarged. Ultrasound ... follow-up exam is done because a potential abnormality needs further evaluation with additional views or a ...

  9. Ultrasound -- Pelvis

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    Full Text Available ... uterine cavity . Three-dimensional (3-D) ultrasound permits evaluation of the uterus and ovaries in planes that ... is done because a potential abnormality needs further evaluation with additional views or a special imaging technique. ...

  10. Ultrasound -- Pelvis

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    Full Text Available ... internal organs, as well as blood flowing through blood vessels. Ultrasound imaging is a noninvasive medical test that ... as clots) narrowing of vessels tumors and congenital vascular malformations reduced or absent blood flow to various ...

  11. Prostate Ultrasound

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    Full Text Available ... information you were looking for? Yes No Please type your comment or suggestion into the following text box: Comment: E-mail: ... Images related to Ultrasound - Prostate Sponsored by Please ...

  12. Prostate Ultrasound

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    Full Text Available ... prostate is enlarged, also known as benign prostatic hyperplasia (BPH) , with measurements acquired as needed for any ... with caption Related Articles and Media Benign Prostatic Hyperplasia (BPH) Prostate Cancer Ultrasound- and MRI-Guided Prostate ...

  13. Ultrasound -- Pelvis

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    Full Text Available ... frequently used to evaluate the reproductive and urinary systems. Ultrasound is safe, noninvasive and does not use ... and evaluate a variety of urinary and reproductive system disorders in both sexes without x-ray exposure. ...

  14. Ultrasound -- Pelvis

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    Full Text Available ... prior to the exam. Bringing books, small toys, music or games can help to distract the child ... modality for the diagnosis and monitoring of pregnant women and their unborn babies. Ultrasound provides real-time ...

  15. Ultrasound -- Pelvis

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    ... prior to the exam. Bringing books, small toys, music or games can help to distract the child ... modality for the diagnosis and monitoring of pregnant women and their unborn babies. Ultrasound provides real-time ...

  16. Ultrasound -- Pelvis

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    Full Text Available ... of urinary and reproductive system disorders in both sexes without x-ray exposure. Risks For standard diagnostic ... have special pediatric considerations. The teddy bear denotes child-specific content. Related Articles and Media Sonohysterography Ultrasound - ...

  17. Ultrasound -- Pelvis

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    Full Text Available ... a sample of cells from organs for laboratory testing. Doppler ultrasound images can help the physician to ... computer or television monitor. The image is created based on the amplitude (loudness), frequency (pitch) and time ...

  18. Prostate Ultrasound

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    Full Text Available ... difficulty urinating or an elevated blood test result. It’s also used to investigate a nodule found during ... difficulty urinating. Because ultrasound provides real-time images, it also can be used to guide procedures such ...

  19. Ultrasound -- Pelvis

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    Full Text Available ... the examination process. To ensure a smooth experience, it often helps to explain the procedure to the ... on the amplitude (loudness), frequency (pitch) and time it takes for the ultrasound signal to return from ...

  20. Ultrasound -- Pelvis

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    Full Text Available ... patient consultation. View full size with caption Pediatric Content Some imaging tests and treatments have special pediatric considerations. The teddy bear denotes child-specific content. Related Articles and Media Sonohysterography Ultrasound - Abdomen Children's ( ...

  1. Ultrasound -- Pelvis

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    Full Text Available ... the procedure. Ultrasound examinations are very sensitive to motion, and an active or crying child can prolong ... computer, which in turn creates a real-time picture on the monitor. One or more frames of ...

  2. Ultrasound -- Pelvis

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    Full Text Available ... extract a sample of cells from organs for laboratory testing. Doppler ultrasound images can help the physician ... The transducer sends out inaudible, high—frequency sound waves into the body and then listens for the ...

  3. Trauma Ultrasound.

    Science.gov (United States)

    Wongwaisayawan, Sirote; Suwannanon, Ruedeekorn; Prachanukool, Thidathit; Sricharoen, Pungkava; Saksobhavivat, Nitima; Kaewlai, Rathachai

    2015-10-01

    Ultrasound plays a pivotal role in the evaluation of acute trauma patients through the use of multi-site scanning encompassing abdominal, cardiothoracic, vascular and skeletal scans. In a high-speed polytrauma setting, because exsanguinations are the primary cause of trauma morbidity and mortality, ultrasound is used for quick and accurate detection of hemorrhages in the pericardial, pleural, and peritoneal cavities during the primary Advanced Trauma Life Support (ATLS) survey. Volume status can be assessed non-invasively with ultrasound of the inferior vena cava (IVC), which is a useful tool in the initial phase and follow-up evaluations. Pneumothorax can also be quickly detected with ultrasound. During the secondary survey and in patients sustaining low-speed or localized trauma, ultrasound can be used to help detect abdominal organ injuries. This is particularly helpful in patients in whom hemoperitoneum is not identified on an initial scan because findings of organ injuries will expedite the next test, often computed tomography (CT). Moreover, ultrasound can assist in detection of fractures easily obscured on radiography, such as rib and sternal fractures.

  4. Developmental programming: Impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics.

    Science.gov (United States)

    Padmanabhan, V; Smith, P; Veiga-Lopez, A

    2012-08-01

    Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep with obesity exaggerating such defects. Developmental studies found ovarian reserve is similar in control and prenatal T sheep at fetal day 140, with prenatal T females showing increased follicular recruitment and persistence at 10 months of age (postpubertal). This study tested if prenatal T sheep show accelerated depletion prepubertally and if depletion of ovarian reserve would explain loss of cyclicity in prenatal T females and its amplification by postnatal obesity. Stereological examinations were performed at 5 (prepubertal, control and prenatal T) and 21 months (control, prenatal T and prenatal T obese, following estrus synchronization) of age. Obesity was induced by overfeeding from weaning. At 5 months, prenatal T females had 46% less primordial follicles than controls (P obesity did not exaggerate the impact of prenatal T on follicular recruitment indicating that compounding effects of obesity on loss of cyclicity females is not due to depletion of ovarian reserve. Assessment of follicular dynamics across several time points during the reproductive life span (this and earlier study combined) provides evidence supportive of a shift in follicular dynamics in prenatal T females from one of accelerated follicular depletion initiated prior to puberty to stockpiling of growing follicles after puberty, a time point critical in the development of the polycystic ovary syndrome phenotype.

  5. Prenatal diagnosis of abnormal umbilical cord insertion: a rare case of furcate insertion.

    Science.gov (United States)

    Fujita, Yasuyuki; Yumoto, Yasuo; Kato, Kiyoko

    2017-04-01

    Furcate insertion (FI) is an extremely rare abnormality of umbilical cord insertion. One of the complications associated with FI is hemorrhage from the umbilical vein at the site of FI of the umbilical cord, which can cause sudden intrauterine fetal death. Because of its rarity, no prenatal diagnosis of FI has been reported. A 31-year-old woman at 34 weeks' gestation was referred to us for suspected abnormal cord insertion. Ultrasonography showed normal fetal growth and amniotic fluid volume, with no fetal anomalies. Although the umbilical cord contained three vessels inserted at the center of the placenta, the umbilical vessels separated from the cord substance before their insertion to the placenta. Based on these findings, the patient was diagnosed with FI. During labor at 37 weeks' gestation, fetal heart rate was normal and a healthy neonate was delivered. At macroscopic examination, the umbilical cord was inserted in the middle of the placenta, and the placental parenchymal tissue just under the cord insertion was deficient and had been changed to white, elastic hard tissue. Pathological examination of the white tissue revealed fibrin deposition and focal infarction. Although FI is a very rare condition, prenatal diagnosis can be achieved through detailed color Doppler ultrasound studies. Therefore, taking precautions and keeping in mind the poor fetal outcome associated with FI are preferred.

  6. Technology-Driven and Evidence-Based Genomic Analysis for Integrated Pediatric and Prenatal Genetics Evaluation

    Institute of Scientific and Technical Information of China (English)

    Yuan Wei; Fang Xu; Peining Li

    2013-01-01

    The first decade since the completion of the Human Genome Project has been marked with rapid development of genomic technologies and their immediate clinical applications.Genomic analysis using oligonucleotide array comparative genomic hybridization (aCGH) or single nucleotide polymorphism (SNP) chips has been applied to pediatric patients with developmental and intellectual disabilities (DD/ID),multiple congenital anomalies (MCA) and autistic spectrum disorders (ASD).Evaluation of analytical and clinical validities of aCGH showed > 99% sensitivity and specificity and increased analytical resolution by higher density probe coverage.Reviews of case series,multi-center comparison and large patient-control studies demonstrated a diagnostic yield of 12%-20%; approximately 60% of these abnormalities were recurrent genomic disorders.This pediatric experience has been extended toward prenatal diagnosis.A series of reports indicated approximately 10% of pregnancies with ultrasound-detected structural anomalies and normal cytogenetic findings had genomic abnormalities,and 30% of these abnormalities were syndromic genomic disorders.Evidence-based practice guidelines and standards for implementing genomic analysis and web-delivered knowledge resources for interpreting genomic findings have been established.The progress from this technology-driven and evidence-based genomic analysis provides not only opportunities to dissect disease-causing mechanisms and develop rational therapeutic interventions but also important lessons for integrating genomic sequencing into pediatric and prenatal genetic evaluation.

  7. Children's (Pediatric) Abdominal Ultrasound Imaging

    Science.gov (United States)

    ... the abdomen is a safe, noninvasive test that uses sound waves to produce a clear picture of the internal organs and blood vessels ... Ultrasound imaging is extremely safe and does not use any ionizing radiation. Ultrasound scanning gives a clear picture of soft tissues that do not show ...

  8. Ultrasound-induced microbubble coalescence

    NARCIS (Netherlands)

    Postema, Michiel; Marmottant, Philippe; Lancée, Charles T.; Hilgenfeldt, Sascha; Jong, de Nico

    2004-01-01

    We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This f

  9. NON-INVASIVE PRENATAL DIAGNOSIS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Madhusudan Dey, Sumita Agarwal and Sumedha Sharma

    2013-04-01

    Full Text Available ABSTRACT: Aneuploidies are one of the important causes of perinatal morbidity and mortality. Initially screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high risk for aneuploidies were offered invasive testing. Recently, various methods including non-invasive prenatal testing (NIPT by analysis of cell-free fetal DNA (cffDNA in maternal blood has shown promise for highly accurate detection of common fetal autosomal trisomies. Incorporating these new non-invasive technologies into clinical practice will impact the current prenatal screening paradigm for fetal aneuploidy, in which genetic counselling plays an integral role. The advantage of the technique being elimination of risks such as miscarriage associated with invasive diagnostic procedures. But then this new technique has its own set of technical limitations and ethical issues at present and further research is required before implementation. Data was obtained through a literature search via Pubmed and Google as well as detailed search of our library database.

  10. Karyotype analysis with amniotic fluid in 12365 pregnant women with indications for genetic amniocentesis and strategies of prenatal diagnosis.

    Science.gov (United States)

    Xiao, H; Yang, Y L; Zhang, C Y; Liao, E J; Zhao, H R; Liao, S X

    2016-01-01

    We explored the strategies of prenatal diagnosis by foetal karyotype analysis in pregnant women with indications for genetic amniocentesis. Karyotype analysis of amniotic fluid was performed on 12365 pregnant women with indications for genetic amniocentesis. The detection rates and distributions of abnormal karyotypes were observed in a variety of indications for genetic amniocentesis. The detection rates of abnormal karyotype were 57.4% in either a mother or father with chromosomal abnormality, 8.5% in the pregnant women with pathological ultrasound finding (PUF), 2.79% in the pregnant women with advanced age (35 years and over) and 2.23% in the women with abnormal maternal serum screening (MSS) tests. Foetal abnormal karyotype was found in 86 pregnant women with PUF; of the 86 pregnant women, 42 had trisomy 13, 18 or 21. Of the 12365 pregnant women, foetal abnormal karyotype was found in 428 (3.46%); of the 428 foetuses, only 154 had trisomy 13, 18 or 21. In the pregnant women with abnormal MSS, 111 foetuses had abnormal karyotype, but only 36 foetuses had trisomy 13, 18 or 21. We conclude that (1) ultrasound is an important approach to prevent the birth of foetuses with chromosomal disease. (2) Non-invasive prenatal DNA detection cannot completely replace invasive prenatal diagnosis and MSS. (3) The strategies of prenatal diagnosis: Genetic amniocentesis is strongly recommended for the pregnant women with indications for genetic amniocentesis. For pregnant women who refuse invasive prenatal diagnosis, non-invasive prenatal DNA detection is first performed. If the results of non-invasive prenatal DNA detection are negative, the pregnant women are followed up by ultrasound; if the results of non-invasive prenatal DNA detection are positive, the pregnant women should undergo invasive prenatal diagnosis.

  11. Prenatal diagnosis and molecular genetic analysis of short rib-polydactyly syndrome type III (Verma-Naumoff in a second-trimester fetus with a homozygous splice site mutation in intron 4 in the NEK1 gene

    Directory of Open Access Journals (Sweden)

    Chih-Ping Chen

    2012-06-01

    Conclusion: Polydactyly, micromelia, metaphyseal spurs, widened humeral metaphyses, and shortened ribs can be prominent prenatal ultrasound findings of SRPS III. The present case provides evidence for a correlation of a mutation in the NEK1 gene with SRPS III.

  12. General Ultrasound Imaging

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    Full Text Available ... are the limitations of General Ultrasound Imaging? What is General Ultrasound Imaging? Ultrasound is safe and painless, ... through the blood vessels. top of page How is the procedure performed? For most ultrasound exams, you ...

  13. General Ultrasound Imaging

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    Full Text Available ... A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures of the inside of the ... of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or sonography , ...

  14. General Ultrasound Imaging

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    Full Text Available ... of an ultrasound examination. Doppler ultrasound , also called color Doppler ultrasonography, is a special ultrasound technique that ... kidneys. There are three types of Doppler ultrasound: Color Doppler uses a computer to convert Doppler measurements ...

  15. General Ultrasound Imaging

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    Full Text Available ... Index A-Z General Ultrasound Ultrasound imaging uses sound waves to produce pictures of the inside of ... pictures of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or ...

  16. Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome.

    Science.gov (United States)

    Gadson, Alexis; Akpovi, Eloho; Mehta, Pooja K

    2017-08-01

    Rates of maternal morbidity and mortality are rising in the United States. Non-Hispanic Black women are at highest risk for these outcomes compared to those of other race/ethnicities. Black women are also more likely to be late to prenatal care or be inadequate users of prenatal care. Prenatal care can engage those at risk and potentially influence perinatal outcomes but further research on the link between prenatal care and maternal outcomes is needed. The objective of this article is to review literature illuminating the relationship between prenatal care utilization, social determinants of health, and racial disparities in maternal outcome. We present a theoretical framework connecting the complex factors that may link race, social context, prenatal care utilization, and maternal morbidity/mortality. Prenatal care innovations showing potential to engage with the social determinants of maternal health and address disparities and priorities for future research are reviewed. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. 泰安市妇幼保健院2009-2012年超声产前诊断胎儿畸形分析%Analysis of ultrasound prenatal diagnosis fetal malformations of Taianˊs Maternity & Child Hospital

    Institute of Scientific and Technical Information of China (English)

    张格云; 李婧

    2015-01-01

    目的:通过对超声产前诊断结果进行分析。了解胎儿畸形的发生率、发生畸形的种类、年度发展趋势及受孕时间、妊娠年龄与胎儿畸形发生率的关系。方法对2009—2012年来我院进行产前超声诊断的妊娠妇女的一般情况和检查结果逐个进行登记,汇总后进行全面统计分析。结果在8452例孕妇产前超声检查中筛查出胎儿畸形290例,总发生率为3.43%,前3位依次为循环系统畸形98例,发生率1.16%,中枢神经系统畸形55例,发生率0.65%,泌尿系统畸形43例,发生率0.51%;各年度畸形发生率呈现波浪式起伏;受孕时间与胎儿畸形发生率有关,冬、春季受孕者胎儿畸形发生率明显高于夏、秋季受孕妇女;妊娠妇女年龄同胎儿畸形发生率有关,年龄越大,畸形发生率越高。结论超声检查在产前诊断中具有极其重要的价值。超声检查可以筛查出绝大多数的胎儿解剖结构畸形,对降低出生缺陷的发生率,提高人口素质是一项极为有力的举措。应广泛开展围产期保健和优生优育的健康教育。%Objective Through the analysis of the results of ultrasound prenatal diagnosis in our hospital, to understand the relationship between the incidence, the type, the development trend of the year, time to pregnancy,gestational age and the incidence of fetal malformations. Methods General conditions and test results of pregnant women from 2009 to 2012 were regis-tered individually, to conduct a comprehensive summary of the statistical analysis. Results There are 290 fetal malformations in 8 452 women who took the ultrasonic testing with a total incidence of 3. 43%. Among the 290 malformations, the top three are 98 circulatory system malformations with an incidence of 1. 16%, 55 central nervous system malformations with an incidence of 0. 65% and 43 urinary system malformations with an incidence of 0. 51%. The incidence of malformations

  18. Prenatal screening: current practice, new developments, ethical challenges.

    Science.gov (United States)

    de Jong, Antina; Maya, Idit; van Lith, Jan M M

    2015-01-01

    Prenatal screening pathways, as nowadays offered in most Western countries consist of similar tests. First, a risk-assessment test for major aneuploides is offered to pregnant women. In case of an increased risk, invasive diagnostic tests, entailing a miscarriage risk, are offered. For decades, only conventional karyotyping was used for final diagnosis. Moreover, several foetal ultrasound scans are offered to detect major congenital anomalies, but the same scans also provide relevant information for optimal support of the pregnancy and the delivery. Recent developments in prenatal screening include the application of microarrays that allow for identifying a much broader range of abnomalities than karyotyping, and non-invasive prenatal testing (NIPT) that enables reducing the number of invasive tests for aneuploidies considerably. In the future, broad NIPT may become possible and affordable. This article will briefly address the ethical issues raised by these technological developments. First, a safe NIPT may lead to routinisation and as such challenge the central issue of informed consent and the aim of prenatal screening: to offer opportunity for autonomous reproductive choice. Widening the scope of prenatal screening also raises the question to what extent 'reproductive autonomy' is meant to expand. Finally, if the same test is used for two different aims, namely detection of foetal anomalies and pregnancy-related problems, non-directive counselling can no longer be taken as a standard. Our broad outline of the ethical issues is meant as an introduction into the more detailed ethical discussions about prenatal screening in the other articles of this special issue.

  19. Human prenatal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Filkins, K.; Russo, R.J.

    1985-01-01

    The multiauthor text is written as a ''guide to rationalize and clarify certain aspects of diagnosis, general counseling and intervention'' for ''health professionals who provide care to pregnant women.'' The text is not aimed at the ultrasonographer but rather at the physicians who are clinically responsible for patient management. Chapters of relevance to radiologists include an overview of prenatal screening and counseling, diagnosis of neural tube defects, ultrasonographic (US) scanning of fetal disorders in the first and second trimesters of pregnancy, US scanning in the third trimester, multiple gestation and selective termination, fetal echo and Doppler studies, and fetal therapy. Also included are overviews of virtually all currently utilized prenatal diagnostic techniques including amniocentesis, fetal blood sampling, fetoscopy, recombinant DNA detection of hemoglobinopathies, chorionic villus sampling, embryoscopy, legal issues, and diagnosis of Mendelian disorders by DNA analysis.

  20. Prenatal testosterone and stuttering.

    Science.gov (United States)

    Montag, Christian; Bleek, Benjamin; Breuer, Svenja; Prüss, Holger; Richardt, Kirsten; Cook, Susanne; Yaruss, J Scott; Reuter, Martin

    2015-01-01

    The prevalence of stuttering is much higher in males compared to females. The biological underpinnings of this skewed sex-ratio is poorly understood, but it has often been speculated that sex hormones could play an important role. The present study investigated a potential link between prenatal testosterone and stuttering. Here, an indirect indicator of prenatal testosterone levels, the Digit Ratio (2D:4D) of the hand, was used. As numerous studies have shown, hands with more "male" characteristics (putatively representing greater prenatal testosterone levels) are characterized by a longer ring finger compared to the index finger (represented as a lower 2D:4D ratio) in the general population. We searched for differences in the 2D:4D ratios between 38 persons who stutter and 36 persons who do not stutter. In a second step, we investigated potential links between the 2D:4D ratio and the multifaceted symptomatology of stuttering, as measured by the Overall Assessment of the Speaker's Experience of Stuttering (OASES), in a larger sample of 44 adults who stutter. In the first step, no significant differences in the 2D:4D were observed between individuals who stutter and individuals who do not stutter. In the second step, 2D:4D correlated negatively with higher scores of the OASES (representing higher negative experiences due to stuttering), and this effect was more pronounced for female persons who stutter. The findings indicate for the first time that prenatal testosterone may influence individual differences in psychosocial impact of this speech disorder. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Features and prognosis of fetal tricuspid valve regurgitation by Prenatal Ultrasound Cardiogram Examination%产前超声检测胎儿三尖瓣反流及其预后初探

    Institute of Scientific and Technical Information of China (English)

    刘清求; 余燕明; 肖迎军; 高小午; 陈宏颖

    2011-01-01

    Objective: To investigate the relations between the causes and reflux extent of fetal tricuspid valve regurgitation and fetal prognosis. Methods: Segmental analysis was used in examining the heart and other structures outside the heart of 52 cases with fetal tricuspid regurgitation which were found by routine ultrasound cardiogram examination from January 2009 to September 2010 in our hospital. All cases were classified into three groups that is congenital heart disease group, non - congenital heart disease group, simple regurgitation group in the light of without other abnormalities or not. Features and prognosis of fetal tricuspid valve regurgitation in three groups were observed and analysed. Results: There are 10 patients in congenital heart disease group including 3 cases with mild regurgitation and 7 cases with moderate regurgitation, resulting in 8 cases induced abortion and 2 cases survived; There are 23 cases in non- congenital heart disease group including 19 cases with mild regurgitation and 4 cases with moderate regurgitation, resulting in 4 cases induced abortion and 19 cases survived; There are 19 cases in simple regurgitation group including 17 cases with mild regurgitation and 2 cases with moderate regurgitation, resulting in 19 cases survived. Conclusion: The cause and reflux degree of fetal tricuspid valve regurgitation are related to fetal prognosis. Mild to moderate tricuspid regurgitation accompanied with a good general condition, which the fetal prognosis is good; tricuspid regurgitation combined severe structural abnormalities inside and outside the structure of fetal heart, which the fetal prognosis is poor.%目的 探讨胎儿三尖瓣反流原因、程度与胎儿预后的关系.方法 对2009年1月至2010年9月行常规超声检查所发现的52例胎儿三尖瓣反流病例,采用节段分析法,对胎儿进行系统超声心动图检查和心外其他结构全面细致地检查.根据检查情况分先心组、非先心组、单纯

  2. 二维、三维超声技术检测正常胎儿胸腺的研究%Prenatal assessment of the fetal thymus: utility of 2D and 3D ultrasound healthy fetuses

    Institute of Scientific and Technical Information of China (English)

    李凌; 周启昌; 邹琳; 蒲大荣; 章鸣; Joshua Copel; Mert Bahtiyar

    2011-01-01

    Objective To establish the normative data of the 2D and 3D ultrasound (US)measurements of the developing fetal thymus and comparing the 2DUS and 3DUS measurements of the fetal thymus. Methods The normal fetuses' thymus of 567 cases were assessed, and maximum transverse diameter(MTD),antero posterior diameter (APD), suprainferior diameter (SID), maximum transverse area (MTA) were measured by 2DUS,and thymic volume(TV) was measured by 3DUS. Results 2DUS,3DUS assessments of the fetal thymic MTD, APD, SID, MTA and TV were possible in 541 of 567 normal singletons. The fetal thymic 2D diameters/area and 3D volume grow with the gestational age(GA) in linear correlation. The 3D-US TV measurements and GA was significantly higher than that of any individual 2DUS measurements and GA ( P <0.05). Conclusions This study presents the normative data of the 2DUS and 3DUS measurements of the developing fetal thymus. 3DUS fetal thymus volume is more significantly correlated to GA than the other 2DUS measurements, which indicates 3DUS measurement of the fetal thymus is more accurate than that of 2DUS.%目的 建立胎儿胸腺二维各径线和三维体积的正常值,并比较胎儿胸腺的二维、三维超声测量.方法 采集567例正常胎儿胸腺的二维超声测值,包括最大横径、前后径、上下径、最大横截面积及三维超声体积.结果 567例胎儿中541例胎儿满意获得胎儿胸腺的最大横径、前后径、上下径和最大横截面积和体积.胎儿胸腺二维各径线、三维体积均随孕周的增加而增加,与孕周均呈直线相关,三维体积与孕周的相关性明显高于二维超声测值(P<0.05).结论 本研究建立了胎儿胸腺二维超声面积、周长、直径、横径和三维超声体积的正常参考值.三维超声测量胎儿胸腺体积与孕周相关性更高,提示较二维超声测量更为准确.

  3. Prenatal diagnosis of ectopia cordis at 10 weeks of gestation using two-dimensional and three-dimensional ultrasonography.

    Science.gov (United States)

    Liang, R I; Huang, S E; Chang, F M

    1997-08-01

    We report here the earliest prenatal diagnosis to date of a case of ectopia cordis using both two-dimensional and three-dimensional ultrasound at 10 weeks of gestation. Both two-dimensional and three-dimensional ultrasound clearly revealed a thoracoabdominal ectopia cordis and an omphalocele. Histopathological examination confirmed the prenatal ultrasonic findings. In addition to an ectopia cordis, a supraumbilical hepato-omphalocele, absence of a pericardium and an anterior diaphragmatic defect were seen, although there was a normal sternum. These pathological findings, suggested that our case was a variant of pentalogy of Cantrell.

  4. Mesenchymal hamartoma of the chest wall: prenatal sonographic manifestations.

    Science.gov (United States)

    Wie, Jeong ha; Kim, Ju Yeon; Kwon, Ji Young; Ko, Hyun Sun; Shin, Jong Chul; Park, In Yang

    2013-06-01

    Mesenchymal hamartoma of the chest wall is a rare, benign lesion that arises from one or more ribs, almost exclusively found in infants. Some cases that developed in the fetal period have been reported, but accurate diagnosis was usually possible only after birth, except in a few cases in which fetal magnetic resonance imaging or computed tomography were performed. We present a case of a congenital mesenchymal hamartoma of the chest wall. Although the diagnosis was not confirmed until birth, the prenatal sonographic examination showed strongly suggestive findings. We review the published reports on this condition, and suggest the prenatal sonographic features. Prenatal sonography is valuable in the differential diagnosis of chest mass.

  5. Congenital dacryocystocele: prenatal MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Yazici, Zeynep [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Uludag University, Department of Radiology, Faculty of Medicine, Bursa (Turkey); Kline-Fath, Beth M.; Rubio, Eva I.; Calvo-Garcia, Maria A.; Linam, Leann E. [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Yazici, Bulent [Uludag University, Department of Ophthalmology, Faculty of Medicine, Bursa (Turkey)

    2010-12-15

    Congenital dacryocystocele can be diagnosed prenatally by imaging. Prenatal MRI is increasingly utilized for fetal diagnosis. To present the radiological and clinical features of seven fetuses with congenital dacryocystocele diagnosed with prenatal MRI. The institutional database of 1,028 consecutive prenatal MR examinations performed during a period of 4 years was reviewed retrospectively. The cases of congenital dacryocystocele were identified by reading the report of each MRI study. The incidence of dacryocystocele diagnosed with prenatal MRI was 0.7% (n=7/1,028). The dacryocystocele was bilateral in three fetuses. Mean gestational age at the time of diagnosis was 31 weeks. The indication for prenatal MRI was the presence or the suspicion of central nervous system abnormality in six fetuses and diaphragmatic hernia in one. Dacryocystocele was associated with an intranasal cyst in six of ten eyes. Prenatal sonography revealed dacryocystocele in only two of seven fetuses. Of eight eyes with postnatal follow-up, four did not have any lacrimal symptoms. Prenatal MRI can delineate congenital dacryocystocele more clearly and in a more detailed fashion than ultrasonography. Presence of dacryocystocele was symptomatic in only 50% of our patients, supporting that prenatal diagnosis of dacryocystocele might follow a benign course. (orig.)

  6. The application value of spatiotemporal image correlation combined with tomographic ultrasound imaging in prenatal screening of common cardiac malposition%时间空间相关成像技术联合断层超声显像技术在产前筛查常见心脏位置异常中的应用价值

    Institute of Scientific and Technical Information of China (English)

    吴娟; 栗河舟; 丛娟; 刘云

    2012-01-01

    目的:探讨时间空间相关成像技术联合断层超声显像技术(TUI-STIC技术)在产前筛查常见心脏位置异常中的临床应用价值.方法:应用时间空间相关成像技术采集胎儿心脏的容积图像,再应用断层超声显像技术进行分析,要求清晰显示上腹部横切面及四腔心切面并标明左右方位.结果:199例心脏位置异常胎儿心脏容积数据经断层超声显像技术处理均获得满意的上腹部横切面及四腔心切面.其中右位心67例;左旋心5例;中位心7例;异位心2例;心脏移位107例;心脏异构11例.结论:判断胎儿心脏位置的主要切面是上腹部横切面和四腔心切面.时间空间相关成像技术联合断层超声显像技术简易、准确,可作为产前筛查胎儿心脏位置异常的有效方法.%Objective; To explore the clinical application value of spatiotemporal image correlation combined with tomographic ultrasound imaging (STIC -TUI technique) in prenatal screening of common cardiac malposition. Methods; STIC technique was used to collect fetal cardiac volume images, then TUI technique was used for analysis, the transverse section through the upper abdominal portion and four - chamber view were displayed clearly, and the positions were indicated. Results; Satisfactory transverse section through the upper abdominal portion and four - chamber view were obtained after analyzing the data of fetal cardiac volume of 199 cases with fetal cardiac malposition by TUI technique. Sixty -seven cases with dextrocardia, five cases with levoverted heart, seven cases with mesocardia, two cases with exocardia, one hundred and seven cases with displacement of heart, and eleven cases with heterogeneous heart were found. Conclusion; The main views to judge fetal cardiac position include transverse section through the upper abdominal portion and four - chamber view, STIC - TUI technique is simple and accurate, which can be used as an effective method for

  7. Therapeutic ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Lawrence A [Center for Industrial and Medical Ultrasound, 1013 NE 40th Street, University of Washington, Seattle, WA 98105 (United States)

    2004-01-01

    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  8. Prenatal diagnosis of hemoglobinopathies: from fetoscopy to coelocentesis

    Directory of Open Access Journals (Sweden)

    Gianfranca Damiani

    2014-09-01

    Full Text Available Prenatal diagnosis of hemoglobinopathies involves the study of fetal material from blood, amniocytes, trophoblast coelomatic cells and fetal DNA in maternal circulation. Its first application dates back to the 70s and it involves globin chain synthesis analysis on fetal blood. In the 1980s molecular analysis was introduced as well as amniocentesis and chorionic villi sampling under high-resolution ultrasound imaging. The application of direct sequencing and polymerase chain reactionbased methodologies improved the DNA analysis procedures and reduced the sampling age for invasive prenatal diagnosis from 18 to 16- 11 weeks allowing fetal genotyping within the first trimester of pregnancy. In the last years, fetal material obtained at 7-8 weeks of gestation by coelocentesis and isolation of fetal cells has provided new platforms on which to develop diagnostic capabilities while non-invasive technologies using fetal DNA in maternal circulation are starting to develop.

  9. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  10. Snobbish Show

    Institute of Scientific and Technical Information of China (English)

    YIN PUMIN

    2010-01-01

    @@ The State Administration of Radio,Film and Television (SARFT),China's media watchdog,issued a new set of mles on June 9 that strictly regulate TV match-making shows,which have been sweeping the country's primetime programming. "Improper social and love values such as money worship should not be presented in these shows.Humiliation,verbal attacks and sex-implied vulgar content are not allowed" the new roles said.

  11. Prenatal evaluation of atelencephaly

    Energy Technology Data Exchange (ETDEWEB)

    Nagaraj, Usha D. [Cincinnati Children' s Hospital Medical Center, Department of Radiology and Medical Imaging, Cincinnati, OH (United States); University of Cincinnati College of Medicine, Cincinnati, OH (United States); Lawrence, Anne [Children' s National Medical Center, Division of Fetal and Transitional Medicine, Washington, DC (United States); Vezina, L.G.; Bulas, Dorothy I. [Children' s National Medical Center, Department of Diagnostic Imaging and Radiology, Washington, DC (United States); The George Washington University School of Medicine and Health Sciences, Washington, DC (United States); DuPlessis, Adre J. [Children' s National Medical Center, Division of Fetal and Transitional Medicine, Washington, DC (United States); The George Washington University School of Medicine and Health Sciences, Washington, DC (United States)

    2016-01-15

    Atelencephaly is a rare lethal congenital brain malformation characterized by underdevelopment of the prosencephalon and is often accompanied by the facial features seen in some cases of holoprosencephaly, such as cyclopia. We report a case of atelencephaly in the fetus with characteristic ultrasound findings. In addition, we report the findings on fetal MRI, which have not been previously described in the literature. (orig.)

  12. Clinical outcome and imaging changes after intraarticular (IA) application of etanercept or methylprednisolone in rheumatoid arthritis: Magnetic resonance imaging and ultrasound-Doppler show no effect of IA injections in the wrist after 4 weeks

    DEFF Research Database (Denmark)

    Boesen, M.; Boesen, L.; Jensen, K.E.

    2008-01-01

    Objective. To assess the magnetic resonance imaging (MRI) and ultrasound (US) changes in the wrist of patients with rheumatoid arthritis (RA) 4 weeks after an US guided intraarticular (IA) injection. Methods. Contrast enhanced MRI and US-Doppler were performed at baseline and 4 weeks after IA...... injection of either 40 mg methylprednisolone (n = 12) or 25 mg etanercept (n = 13) in 25 patients with RA taking disease modifying antirheumatic drugs with a therapy-resistant wrist joint. All injections were US guided. Results. There was an improvement in swollen target joint score (p ...-29) in the total group was unchanged after 4 weeks (p = 0.13), whereas MRI erosion score increased in the total group from baseline, 17.88 (range 7-40), to 4 weeks, 18.25 (range 7-40) (p

  13. Prenatal Sonographic Findings of Polysplenic Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jeong Hyun; Suh, Jeong Soo [Ewha Womans University College of Medicine, Seoul (Korea, Republic of); Lee, Young Ho [Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul (Korea, Republic of)

    2004-09-15

    We report 6 cases of polysplenic syndrome diagnosed on prenatal sonography. The mean menstrual age at the time of presentation was 275 weeks (range 184 to 38 weeks). All cases were examined using level-II prenatal sonography. The sonographic findings of polysplenic syndrome were retrograde analyzed and compared to the autopsy or postnatal findings. Polysplenia was detected in 5 cases on the prenatal sonography. Associated cardiovascular anomalies were detected in all 6 cases, all of which had more than one anomaly, namely complete atrioventricular septal defect in two cases, double outlet right ventricle combined with rudimentary LV or mitral atresia in two cases and VSD and ASD in one case each. There were three cases of interrupted IVC with azygous continuation of the posterior thorax. Bradycardia was observed in 2 cases, one of which showed AV dissociation of rhythm. Visceral abnormalities were present in all cases and there were combined anomalies such as echogenic bowel, pelviectasia, horseshoe kidney, and posterior neck cystic hygroma and fetal hydrops. Four cases terminated pregnancy. The autopsy results of 2 cases were comparable to those of the prenatal sonography, however autopsies were not performed in 2 cases. One fetus near term was delivered and the baby subsequently underwent heart surgery and was still alive at the last follow-up. The remaining one case was lost to follow-up. If multiple fetal anomalies, including complex heart disease and polysplenia, are detected in the prenatal sonography, a diagnosis of polysplenic syndrome can be made. IVC interruption with azygous continuation can also be helpful in the diagnosis of polysplenic syndrome, and this can be observed by detecting the double vessel of the posterior thorax

  14. Ultrasound appearance of knuckle pads

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Ben, R. [Univ. of Alabama, Birmingham (United States). Dept. of Diagnostic Radiology; Dehghanpisheh, K.; Chatham, W.W.; Alarcon, G.S. [Univ. of Alabama, Birmingham (United States). Dept. of Medicine; Lee, D.H.; Oakes, J. [Univ. of Alabama, Birmingham (United States). Dept. of Surgery

    2006-11-15

    We describe the ultrasound appearance of knuckle pads. Retrospective analysis of imaging in a series of five patients initially referred for evaluation of periarticular soft-tissue swelling of the hands involving the dorsum of the PIP and MP joints. Two patients had associated Dupuytren's contractures. Ultrasound and radiographs of the hands in all patients were reviewed and correlated with clinical history and physical exams. Radiographs in four patients demonstrated dorsal soft-tissue thickening. Ultrasound exams showed increased dorsal subcutaneous thickening, with either diffuse or focal hypoechoic areas corresponding to the areas of soft-tissue fullness identified on physical exam. No erosions or synovial proliferation were identified either by radiographs or ultrasound of the underlying joints. Knuckle pads can sometimes be difficult to distinguish from synovitis on physical examination. Musculoskeletal ultrasound can quickly identify these superficial lesions and exclude underlying synovial proliferation.

  15. The place of prenatal clases.

    Science.gov (United States)

    Enkin, M W

    1978-11-01

    The past 20 years has shown an exponential rise in both obstetrical intervention and family centred maternity care. Prenatal classes, although not as yet fully integrated into prenatal care, fill a vital role in teaching couples the information, skills, and attitudes required to participate actively in their reproductive care, and to recognize both their rights and their responsibilities.

  16. 中孕期系统超声筛查对检出异常胎儿的临床价值及产前超声筛查漏检病例初步分析%Clinical value of systematic ultrasound screening for fetal abnormality in second trimester and analyzing the Undetected cases of prenatal ultrasound screening preliminary

    Institute of Scientific and Technical Information of China (English)

    荆春丽; 孙寒冰; 沙恩波; 王彦; 郭邑

    2011-01-01

    Objective To evaluate the clinical value of systematic ultrasound screening for fetal abnormality in second trimester, and to analyze the causes of misdiagnosis and medical malpractice. Methods By checking up 12 682 cases of 20-24 weeks pregnant women with using systematic ultrasound screening, storied the information in the workstation, and then did the evaluate, following-up interviews and statistics. Results Six hundred sixteen cases had been diagnosed out with abnormal structure or fetal abnormality. Detection rate 4. 86%( 616/12 682 ) and 18 cases with abnormal structure were failed. Failed rate 0. 14% ( 18/12 682 ), which were confirmed after birth. Including 2 cases with hand abnormality, 1 case with 1 degree cleft lip, 6 cases with ventricular septum defect( ≤4 mm ),1 case with tetralogy of fallot, 1 case with congenital defect of external ear, 1 case with abnormalities of the genitalia, 2 cases with cleft palate only, 1 case with strephenopodia,l case with caudal regression syndrome,l case with sacral spinal bifida with tethered cord fat, 1case with sacrococcygeal cystic spina bifida. 3 of above cases ( 1 case in caudal regression syndrome, 1 case in sacral spinal bifida with tethered cord fat, 1 case of sacrococcygeal cystic spina bifida ) caused medical malpractice after birth. There were 239 cases of the above 616 cases with fetal abnormality had abortions in our hospital,( 1 ) Necropsy 23 cases among the abortions were conformed to the ultrasound diagnosis. ( 2 ) Appearance of the abnormality 142( cleft lip 43 )cases among the abortions were conformed to the ultrasound diagnosis. ( 3 ) 61 cases had been diagnosed out with fetal visceral abnormality, without necropsy 13 cases among them were polyhydramnios or oligohydramnios. Three hundred seventy-seven exceptional cases were primary abortions, which also confirmed our diagnosis after the hospital' stelephone interview. Conclusion The systematic ultrasound screening can improve the detection rate

  17. Prostate Ultrasound

    Medline Plus

    Full Text Available ... and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the probe through ... during a single exam. The transducer sends out high-frequency sound waves (that the human ear cannot hear) ...

  18. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the probe through ... during a single exam. The transducer sends out high-frequency sound waves (that the human ear cannot hear) ...

  19. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... and Resources RTAnswers.org Radiation Therapy for Gynecologic Cancers Radiation Therapy for Prostate Cancer top of page This page was reviewed on ... with caption Pediatric Content Some imaging tests and treatments have special pediatric ... Images related to Ultrasound - Pelvis Sponsored by Please ...

  20. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... Español More Info Images/Videos About Us News Physician Resources Professions Site Index A-Z Ultrasound - Pelvis ... imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. There are three ...

  1. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available Toggle navigation Test/Treatment Patient Type Screening/Wellness Disease/Condition Safety En Español More Info Images/Videos About Us News Physician ... blood vessels. Ultrasound imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. ...

  2. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available Toggle navigation Test/Treatment Patient Type Screening/Wellness Disease/Condition Safety En Español More Info Images/Videos About Us News Physician ... blood vessels. Ultrasound imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. ...

  3. EROBATIC SHOW

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Visitors look at plane models of the Commercial Aircraft Corp. of China, developer of the count,s first homegrown large passenger jet C919, during the Singapore Airshow on February 16. The biennial event is the largest airshow in Asia and one of the most important aviation and defense shows worldwide. A number of Chinese companies took part in the event during which Okay Airways, the first privately owned aidine in China, signed a deal to acquire 12 Boeing 737 jets.

  4. Microarray application in prenatal diagnosis: a position statement from the cytogenetics working group of the Italian Society of Human Genetics (SIGU), November 2011.

    Science.gov (United States)

    Novelli, A; Grati, F R; Ballarati, L; Bernardini, L; Bizzoco, D; Camurri, L; Casalone, R; Cardarelli, L; Cavalli, P; Ciccone, R; Clementi, M; Dalprà, L; Gentile, M; Gelli, G; Grammatico, P; Malacarne, M; Nardone, A M; Pecile, V; Simoni, G; Zuffardi, O; Giardino, D

    2012-04-01

    A precise guideline establishing chromosomal microarray analysis (CMA) applications and platforms in the prenatal setting does not exist. The controversial question is whether CMA technologies can or should soon replace standard karyotyping in prenatal diagnostic practice. A review of the recent literature and survey of the knowledge and experience of all members of the Italian Society of Human Genetics (SIGU) Committee were carried out in order to propose recommendations for the use of CMA in prenatal testing. The analysis of datasets reported in the medical literature showed a considerable 6.4% incidence of pathogenic copy number variations (CNVs) in the group of pregnancies with sonographically detected fetal abnormalities and normal karyotype. The reported CNVs are likely to have a relevant role in terms of nosology for the fetus and in the assessment of reproductive risk for the couple. Estimation of the frequency of copy number variations of uncertain significance (VOUS) varied depending on the different CMA platforms used, ranging from 0-4%, obtained using targeted arrays, to 9-12%, obtained using high-resolution whole genome single nucleotide polymorphism (SNP) arrays. CMA analysis can be considered a second-tier diagnostic test to be used after standard karyotyping in selected groups of pregnancies, namely those with single (apparently isolated) or multiple ultrasound fetal abnormalities, those with chromosomal rearrangements, even if apparently balanced, and those with supernumerary marker chromosomes.

  5. Invasive prenatal diagnostic practice in Denmark 1996 to 2006

    DEFF Research Database (Denmark)

    Vestergaard, Christina H F; Lidegaard, Øjvind; Tabor, Ann

    2009-01-01

    The Danish National Board of Health recommended in 2004 routine ultrasound scanning in week 12 with nuchal translucency measurement, combined with the double test to all pregnant women. Those who were found to have a risk of trisomy 21 higher than 1:300 were offered amniocentesis or chorionic...... to 52%. The mean gestational age at which the procedures were done increased--for CVS from week 11 to 13, and for amniocentesis from week 16 to 17. We thus achieved to more than double the offer of prenatal screening and at the same time reduce the number of invasive procedures by 55%....

  6. Outcome of prenatally diagnosed trisomy 6 mosaicism.

    Science.gov (United States)

    Wallerstein, Robert; Oh, Tracey; Durcan, Judy; Abdelhak, Yaakov; Clachko, Mark; Aviv, Hana

    2002-08-01

    We report the prenatal diagnosis of trisomy 6 mosaicism via amniocentesis, in which trisomy 6 cells were identified in three of five culture vessels with 33% (5/15) of colonies showing trisomic cells. The pregnancy was electively terminated and examination revealed minor abnormalities (shortening of the femurs, micrognathia, posterior malrotation of the ears, and bilateral camptomelia of the second digit of the hands and fifth digits of the feet). Cytogenetic analysis of the placenta showed trisomy 6 in 100% of 20 cells studied. Karyotype was 46,XX in 100 cells examined from fetal skin. There are relatively few prenatally diagnosed cases of mosaic trisomy 6 at amniocentesis. Confined placental mosaicism (CPM) has been postulated in other cases where follow-up cytogenetic studies were not available. The present case differs from those previously reported, as it appears to represent CPM of chromosome 6 with phenotypic effects to the fetus.

  7. [Analysis of prenatal follow-up strategies for trisomy 21 affected pregnancies in France].

    Science.gov (United States)

    Dupont, J-M; Simon-Bouy, B; Zebina, A; Pessione, F; Royère, D; Doco-Fenzy, M

    2017-03-01

    The main objective of this study was to screen the prenatal follow-up of women with live birth trisomy 21 child in order to evaluate the proportion of prenatal screening failure versus cases where the women refused either the screening or the prenatal diagnosis of Down syndrome. This study covers the period of time from 2009 to 2012 when the national prenatal screening policy changed from second to first trimester and allows for a comparative assessment of the nationwide efficiency of the various maternal serum marker based strategies. All authorized cytogenetic laboratories sent required data for all cases of trisomy 21 diagnosed in FRANCE in new-borns (less than 1-year-old) from January 2010 to July 2013. A total of 1253 cases of trisomy 21 were diagnosed before 1 year of age whose mother did not had prenatal diagnosis. For 861 of them, information on the prenatal follow-up was available, with 72% of cases where a prenatal screening was organized either by maternal serum marker or by ultrasound. Results of the screening strategy was positive with maternal serum marker in 28% of cases (calculated risk≥1/250), positive because of abnormal ultrasound in 5% and negative with maternal marker screening (whatever the strategy used) in 67% of cases. Detection rate over the period of the study was 82%, with similar efficiency of first and second trimester strategies (83%) but significantly lower with sequential association of first trimester Nuchal translucency measurement and second trimester serum screening (70%). Switching from second trimester to first trimester screening strategy, with as many trisomy 21 foetuses diagnosed with half invasive procedures fulfilled national health policy objectives. Analysis of these data gives useful insights to elaborate a future screening policy involving cell-free foetal DNA sequencing. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Prenatal diagnosis of neonatal hemochromatosis: it is possible?

    Directory of Open Access Journals (Sweden)

    Helena Isabel Lopes

    2015-06-01

    Full Text Available Introduction: Neonatal Hemochromatosis is a rare liver disease of intrauterine onset, defined by neonatal liver failure associated with extrahepatic siderosis. Gestational alloimmune liver disease has been established as the cause of fetal liver injury. At present, there is no effective approach to prenatal diagnosis. Case Report: A 23-year-old pregnant woman presented at 32 weeks of gestation with oligohydramnios and hyperechogenic liver focus on ultrasound. The premature newborn developed multisystem organ failure and died at the second day of life despite aggressive support care. The autopsy allowed the diagnosis of Neonatal Hemochromatosis. Conclusion: The ultrasound identification of hyperechogenic nodular focus on fetal liver may be suggestive of Neonatal Hemochromatosis. Further investigations are needed to identify the specific alloimmune complex in maternal blood. Establishment of the diagnosis in an affected fetus or newborn may have a major impact for the prognosis of disease and for the outcome of future pregnancies.

  9. The Effects of a Minimum Cigarette Purchase Age of 21 on Prenatal Smoking and Infant Health

    OpenAIRE

    Ji Yan

    2014-01-01

    A key goal of US public health policies is to reduce costly adverse birth outcomes to which prenatal smoking is a crucial contributor. This study is the first to evaluate the impacts of a minimum cigarette purchase age of 21 implemented in the state of Pennsylvania on prenatal smoking and infant health. Using a regression discontinuity method, it shows this smoking age of 21 reduces the prenatal daily cigarette consumption by 15 percent and lowers the incidence of low birth weight infants by ...

  10. Prenatal diagnosis of Pena-Shokeir syndrome phenotype by ultrasonography and MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Senocak, Efsun Urger; Oguz, Kader Karli; Akata, Deniz [Hacettepe University Faculty of Medicine, Department of Radiology, Sihhiye, Ankara (Turkey); Haliloglu, Goknur [Hacettepe University Faculty of Medicine, Department of Pediatric Neurology, Ankara (Turkey); Karcaaltincaba, Deniz; Kandemir, Omer [Etlik Zubeyde Hanim Woman' s Hospital, Department of Obstetrics and Gynaecology, Ankara (Turkey)

    2009-04-15

    Pena-Shokeir syndrome phenotype is characterized by neurogenic arthrogryposis, facial anomalies, polyhydramnios and lung hypoplasia. Prenatal US is crucial in showing Pena-Shokeir syndrome phenotype in addition to demonstrating reduced fetal movements or akinesia as an underlying aetiological factor as early as the 14th week of gestation. Several reports of prenatal diagnosis of Pena-Shokeir syndrome phenotype by US have been published. In this report, MRI findings providing prenatal diagnosis are presented. (orig.)

  11. Enzyme extraction by ultrasound from sludge flocs

    Institute of Scientific and Technical Information of China (English)

    YU Guanghui; HE Pinjing; SHAO Liming; ZHU Yishu

    2009-01-01

    Enzymes play essential roles in the biological processes of sludge treatment. In this article, the ultrasound method to extract enzymes from sludge flocs was presented. Results showed that using ultrasound method at 20 kHz could extract more types of enzymes than that ultrasound at 40 kHz and ethylenediamine tetraacetic acid (EDTA) methods. The optimum parameters of ultrasound extraction at 20 kHz were duration of 10 min and power of 480 W. Under the condition, ultrasound could break the cells and extract both the extracellular and intercellular enzymes. Ultrasound power was apparently more susceptive to enzyme extraction than duration, suggesting that the control of power during ultrasound extraction was more important than that of duration. The Pearson correlation analysis between enzyme activities and cation contents revealed that the different types of enzymes had distinct cation binding characteristics.

  12. Effect of Ultrasound on Desorption Equilibrium

    Institute of Scientific and Technical Information of China (English)

    秦炜; 原永辉; 戴猷元

    2001-01-01

    Effects of ultrasound on intensification of separation process were investigated through the experiment of desorption equilibrium behavior. Tri-butyl phosphate (TBP) on NKA-X resin and phenol on a solvent impregnated resin, CL-TBP resin, were used for desorption processes. The desorption rate was measured with and without ultrasound. Desorption equilibrium was studied under various ultrasonic power densities or thermal infusion. Results showed that the desorption rate with ultrasound was much higher than that with normal thermal infusion. Both ultrasound and thermal infusion broke the desorption equilibrium existed at room temperature. However, after the systems were cooled down, the amount of solute desorbed in the liquid phase in the presence of ultrasound was much higher than that at the temperature corresponding to the same ultrasound power. It is proved that the initial desorption equilibrium was broken as a result of the spot energy effect of ultrasound.

  13. Characterization of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenatal mouse.

    Directory of Open Access Journals (Sweden)

    Choon Hwai Yap

    Full Text Available INTRODUCTION: Abnormal fluid mechanical environment in the pre-natal cardiovascular system is hypothesized to play a significant role in causing structural heart malformations. It is thus important to improve our understanding of the prenatal cardiovascular fluid mechanical environment at multiple developmental time-points and vascular morphologies. We present such a study on fetal great arteries on the wildtype mouse from embryonic day 14.5 (E14.5 to near-term (E18.5. METHODS: Ultrasound bio-microscopy (UBM was used to measure blood velocity of the great arteries. Subsequently, specimens were cryo-embedded and sectioned using episcopic fluorescent image capture (EFIC to obtain high-resolution 2D serial image stacks, which were used for 3D reconstructions and quantitative measurement of great artery and aortic arch dimensions. EFIC and UBM data were input into subject-specific computational fluid dynamics (CFD for modeling hemodynamics. RESULTS: In normal mouse fetuses between E14.5-18.5, ultrasound imaging showed gradual but statistically significant increase in blood velocity in the aorta, pulmonary trunk (with the ductus arteriosus, and descending aorta. Measurement by EFIC imaging displayed a similar increase in cross sectional area of these vessels. However, CFD modeling showed great artery average wall shear stress and wall shear rate remain relatively constant with age and with vessel size, indicating that hemodynamic shear had a relative constancy over gestational period considered here. CONCLUSION: Our EFIC-UBM-CFD method allowed reasonably detailed characterization of fetal mouse vascular geometry and fluid mechanics. Our results suggest that a homeostatic mechanism for restoring vascular wall shear magnitudes may exist during normal embryonic development. We speculate that this mechanism regulates the growth of the great vessels.

  14. [Coverage characterization of pre-natal in Maranhão State, Brazil].

    Science.gov (United States)

    Costa, Geny Rose Cardoso; Chein, Maria Bethânia da Costa; Gama, Mônica Elinor Alves; Coelho, Leidyane Silva Caldas; da Costa, Andreia Susana Vieira; Cunha, Carlos Leonardo Figueiredo; Brito, Luciane Maria Oliveira

    2010-01-01

    The purpose of the study was to characterize the coverage of prenatal care in the State of Maranhão. A population-based study, descriptive in 30 municipalities of the State of Maranhão, with 2075 women of childbearing age, with previous pregnancy, from July 2008 to Januray 2009. The results demonstrated that the units of family health accounted for 45.9% of the care of pregnant women and that 46.8% reported carrying out consultations six or more prenatal care during last pregnancy and 64.6% started prenatal in the first three months of pregnancy. The coverage of prenatal care, without regard to adequacy, was 85.6%, however, when considering the coverage of adequate prenatal as established by Brazilian Health Ministry was 43.4%. Although coverage of prenatal above 80%, less than half is considered adequate, showing a gap in primary care quality.

  15. Retrospective review of prenatal care and perinatal outcomes in a group of uninsured pregnant women.

    Science.gov (United States)

    Jarvis, Catherine; Munoz, Marie; Graves, Lisa; Stephenson, Randolph; D'Souza, Vinita; Jimenez, Vania

    2011-03-01

    To assess the adequacy of prenatal care and perinatal outcomes for uninsured pregnant women at two primary care centres in Canada. We conducted a retrospective case comparison study of uninsured women presenting for prenatal care between 2004 and 2007 (n = 71). Control subjects (n = 72) were chosen from provincially insured women presenting for prenatal care during the same period. A modified Kotelchuck Index was used to assess adequacy of care. Frequency of routine prenatal testing (blood tests, ultrasound, cervical swabs, Pap testing, and genetic screening) was compared. Perinatal outcomes assessed included gestational age and birth weight. Uninsured pregnant women presented for initial care 13.6 weeks later than insured women (at 25.6 weeks vs. 12.0 weeks, P care providers (6.6 vs. 10.7, P = 0.05). Using a modified Kotelchuck Adequacy of Prenatal Care Utilization Index, uninsured women were more likely to be categorized as receiving "inadequate care" (uninsured 61.9% vs. insured 11.7%, P care of uninsured pregnant women in Canada. Women in this category presented late for prenatal care, were less likely to have adequate screening tests, and were more likely to receive "inadequate care" as defined by the modified Kotelchuck Index. This information may be valuable in helping to plan programs to improve access to timely and adequate medical care for uninsured pregnant women.

  16. Fetal cerebrovascular circulation: a review of prenatal ultrasound assessment.

    Science.gov (United States)

    Degani, S

    2008-01-01

    Antenatal intrauterine cerebrovascular events were found to play an important role in the pathogenesis of perinatal brain damage. Changes in placental vascular resistance, cardiac contractibility, vessel compliance, and blood viscosity alter the normal dynamics of fetal cerebral circulation. The circulatory mechanisms described in animal fetuses also operate in the human fetus. The isthmus of the aorta represents a watershed area reflecting the redistribution of blood during increased peripheral resistance and hypoxia. The fetal cerebrovascular system acts locally within the skull and interacts with the other components of fetal circulation to compensate by redistribution of blood in case of shortage in resources. The introduction of various sonographic techniques and the collection of data from the arterial and venous cerebral circulation have improved our understanding of the regulatory mechanisms involved in fetal cerebral hemodynamic events. Anatomical and physiological considerations of cerebral vasculature in health and disease are relevant in the research of variations in fetal brain blood perfusion. Changes in flow characteristics in fetal cerebral vasculature can be used for clinical decisions. However, caution is advised before applying research data into practice. The clinical utility is well established in situations of fetal compromise such as growth restriction and anemia.

  17. Prenatal ultrasound parameters in single-suture craniosynostosis

    NARCIS (Netherlands)

    M.J. Cornelissen (Martijn); Apon, I. (Inge); J.J.N.M. van der Meulen (Jacques); I.A.L. Groenenberg (Irene); Kraan – van der Est, M.N. (Mieke N.); I.M.J. Mathijssen (Irene); G.J. Bonsel (Gouke); Cohen – Overbeek, T.E. (Titia E.)

    2017-01-01

    textabstractIntroduction: Although single-suture craniosynostosis is diagnosed sporadically during pregnancy, timely referral is critical for its treatment. Additionally, craniosynostosis leads to increased maternofetal trauma during birth. In the Netherlands, 95% of pregnant women receive a

  18. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... of page How is the procedure performed? For most ultrasound exams, you will be positioned lying face- ... Ultrasound examinations are painless and easily tolerated by most patients. Ultrasound exams in which the transducer is ...

  19. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... data into 3-D images. A Doppler ultrasound study may be part of an ultrasound examination. Doppler ... usually stain or discolor clothing. In some ultrasound studies, the transducer is attached to a probe and ...

  20. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... flat sections of the body. Advancements in ultrasound technology include three-dimensional (3-D) ultrasound that formats ... object is solid or filled with fluid). In medicine, ultrasound is used to detect changes in appearance, ...

  1. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... ultrasound. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... to-use and less expensive than other imaging methods. Ultrasound imaging is extremely safe and does not ...

  2. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... ultrasound. top of page How does the procedure work? Ultrasound imaging is based on the same principles ... not stain or discolor clothing. In some ultrasound studies, the transducer is attached to a probe and ...

  3. Ultrasound guided supraclavicular block.

    LENUS (Irish Health Repository)

    Hanumanthaiah, Deepak

    2013-09-01

    Ultrasound guided regional anaesthesia is becoming increasingly popular. The supraclavicular block has been transformed by ultrasound guidance into a potentially safe superficial block. We reviewed the techniques of performing supraclavicular block with special focus on ultrasound guidance.

  4. Droplets, Bubbles and Ultrasound Interactions.

    Science.gov (United States)

    Shpak, Oleksandr; Verweij, Martin; de Jong, Nico; Versluis, Michel

    2016-01-01

    The interaction of droplets and bubbles with ultrasound has been studied extensively in the last 25 years. Microbubbles are broadly used in diagnostic and therapeutic medical applications, for instance, as ultrasound contrast agents. They have a similar size as red blood cells, and thus are able to circulate within blood vessels. Perfluorocarbon liquid droplets can be a potential new generation of microbubble agents as ultrasound can trigger their conversion into gas bubbles. Prior to activation, they are at least five times smaller in diameter than the resulting bubbles. Together with the violent nature of the phase-transition, the droplets can be used for local drug delivery, embolotherapy, HIFU enhancement and tumor imaging. Here we explain the basics of bubble dynamics, described by the Rayleigh-Plesset equation, bubble resonance frequency, damping and quality factor. We show the elegant calculation of the above characteristics for the case of small amplitude oscillations by linearizing the equations. The effect and importance of a bubble coating and effective surface tension are also discussed. We give the main characteristics of the power spectrum of bubble oscillations. Preceding bubble dynamics, ultrasound propagation is introduced. We explain the speed of sound, nonlinearity and attenuation terms. We examine bubble ultrasound scattering and how it depends on the wave-shape of the incident wave. Finally, we introduce droplet interaction with ultrasound. We elucidate the ultrasound-focusing concept within a droplets sphere, droplet shaking due to media compressibility and droplet phase-conversion dynamics.

  5. Overcoming Biological Barriers with Ultrasound

    Science.gov (United States)

    Thakkar, Dhaval; Gupta, Roohi; Mohan, Praveena; Monson, Kenneth; Rapoport, Natalya

    2011-01-01

    Effect of ultrasound on the permeability of blood vessels and cell membranes to macromolecules and nanodroplets was investigated using mouse carotid arteries and tumor cells. Model macromolecular drug, FITC-dextran with molecular weight of 70,000 Da was used in experiments with carotid arteries. The effect of unfocused 1-MHz ultrasound and and perfluoro-15-crown-5-ether nanodroplets stabilized with the poly(ethylene oxide)-co-poly(D,L-lactide) block copolymer shells was studied. In cell culture experiments, ovarian carcinoma cells and Doxorubicin (DOX) loaded poly(ethylene oxide)-co-polycaprolactone nanodroplets were used. The data showed that the application of ultrasound resulted in permeabilization of all biological barriers tested. Under the action of ultrasound, not only FITC-dextran but also nanodroplets effectively penetrated through the arterial wall; the effect of continuous wave ultrasound was stronger than that of pulsed ultrasound. In cell culture experiments, ultrasound triggered DOX penetration into cell nuclei, presumably due to releasing the drug from the carrier. Detailed mechanisms of the observed effects require further study. PMID:24839333

  6. [Study of long-lasting effects of acute prenatal stress induced forced swimming].

    Science.gov (United States)

    Volodina, M A; Sebentsova, E A; Levitskaia, N G; Kamenskiĭ, A A

    2010-01-01

    The aim of the present work was to assess long-lasting effects of acute prenatal stress in white rats. Forced swimming in cold water on the 7th or the 14th gestational day was used as a prenatal stressor. The prenatal stress led to low birthweight of offspring and their delayed growth rate during the second month of life. Prenatally stressed animals showed abnormalities in exploratory behavior and anxiety, increased emotionality and impaired learning capabilities at the age of 1-2 month. Consequently, acute stress on the 7th and at the 14th day of pregnancy induced long-lasting negative behavioral changes in offspring of stressed white rats.

  7. Breast ultrasound.

    Science.gov (United States)

    Ueno, E

    1996-03-01

    In ultrasound, ultrasonic images are formed by means of echoes among tissues with different acoustic impedance. Acoustic impedance is the product of sound speed and bulk modulus. The bulk modulus expresses the elasticity of an object, and in the human body, the value is increased by conditions such as fibrosis and calcification. The sound speed is usually high in elastic tissues and low in water. In the body, it is lowest in the fatty tissue. Ultrasound echoes are strong on the surface of bones which are hard and have a high sound speed. In organs filled with air such as the lungs, the bulk modulus is low and the sound speed is extremely low at 340 m/s, which produce strong echoes (the sound speed in solid tissues is 1,530 m/s). Human tissue is constructed of units smaller than the ultrasonic beam, and it is necessary to understand back-scattering in order to understand the ultrasonic images of these tissues. When ultrasound passes through tissue, it is absorbed as thermal energy and attenuated. Fiber is a tissue with a high absorption and attenuation rate. When the rate increases, the posterior echoes are attenuated. However, in masses with a high water content such as cysts, the posterior echoes are accentuated. This phenomenon is an important, basic finding for determining the properties of tumors. Breast cancer can be classified into two types: stellate carcinoma and circumscribed carcinoma. Since stellate carcinoma is rich in fiber, the posterior echoes are attenuated or lacking. However, circumscribed carcinoma has a high cellularity and the posterior echoes are accentuated. The same tendency is also seen in benign tumors. In immature fibroadenomas, posterior echoes are accentuated, while in fibroadenomas with hyalinosis, the posterior echoes are attenuated. Therefore, if the fundamentals of this tissue characterization and the histological features are understood, reading of ultrasound becomes easy. Color Doppler has also been developed and has contributed

  8. Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol

    Directory of Open Access Journals (Sweden)

    Sonya Krishna Sobrian

    2011-11-01

    Full Text Available Clinical and experimental reports suggest that prenatal cocaine exposure(PCEalters the offsprings’ social interactions with caregivers and conspecifics. Children exposed to prenatal cocaine show deficits in caregiver attachment and play behavior. In animal models,a developmental pattern of effects that range from deficits in play and social interaction during adolescence, to aggressive reactions during competition in adulthood is seen. This review will focus primarily on the effects of PCE on social behaviors involving conspecifics in animal models. Social relationships are critical to the developing organism; maternally-directed interactions are necessary for initial survival. Juvenile rats deprived of play behavior, one of the earliest forms of non-mother directed social behaviors in rodents, show deficits in learning tasks and sexual competence. Social behavior is inherently conmplex. Because the emergence of appropriate social skills involves the interplay between various conceptual and biological facets of behavior and social information, it may be a particularly sensitive measure of prenatal insult. The social behavior surveyed include social interactions, play behavior/fighting, scent marking and aggressive behavior in the offspring, as well as aspects of maternal behavior. The goal is to determine if there is a consensus of results in the literature with respect to PCE and social behaviors, and to discuss discrepant findings in terms of exposure models, the paradigms and dependent variables, as well as housing conditions, and the sex and age of the offspring at testing. As there is increasing evidence that deficits in social behavior may be sequelae of developmental exposure alcohol, we compare changes in social behaviors reported for prenatal alcohol with those reported for prenatal cocaine. Shortcomings in the both literatures are identified and addressed in an effort to improve the translational value of future experimentation.

  9. Ultrasound of the Thyroid Gland

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Thyroid Thyroid ultrasound uses sound waves to produce ... of Ultrasound of the Thyroid? What is an Ultrasound of the Thyroid? Ultrasound is safe and painless, ...

  10. What Happens during Prenatal Visits?

    Science.gov (United States)

    ... at risk for complications? How does stress affect pregnancy? NICHD Research Information Clinical Trials Resources and Publications What happens during prenatal visits? Skip sharing on social media links Share this: Page Content What happens during ...

  11. Preconception Care and Prenatal Care

    Science.gov (United States)

    ... at risk for complications? How does stress affect pregnancy? NICHD Research Information Clinical Trials Resources and Publications Preconception Care and Prenatal Care: Condition Information Skip sharing on social media links Share this: Page Content What is preconception ...

  12. Prenatal Tests for Down Syndrome

    Science.gov (United States)

    ... PRENATAL TESTS FOR DOWN SYNDROME What Is Down Syndrome? Down syndrome is a common birth defect that includes mental retardation and— often— heart problems. Children with Down syndrome have round faces and almond-shaped eyes that ...

  13. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... through blood vessels. Ultrasound imaging is a noninvasive medical test that helps physicians diagnose and treat medical conditions. Conventional ultrasound displays the images in thin, ...

  14. Noninvasive prenatal testing: the future is now.

    Science.gov (United States)

    Norwitz, Errol R; Levy, Brynn

    2013-01-01

    Prenatal detection of chromosome abnormalities has been offered for more than 40 years, first by amniocentesis in the early 1970s and additionally by chorionic villus sampling (CVS) in the early 1980s. Given the well-recognized association between increasing maternal age and trisomy,1-3 the primary utilization of prenatal testing has been by older mothers. This has drastically reduced the incidence of aneuploid children born to older mothers.4 Although younger women have relatively low risks of conceiving a child with aneuploidy, the majority of pregnant women are in their late teens, 20s, and early 30s. As such, most viable aneuploid babies are born to these younger mothers.5 Invasive prenatal diagnosis (CVS and amniocentesis) is not a feasible option for all low-risk mothers, as these procedures carry a small but finite risk and would ultimately cause more miscarriages than they would detect aneuploidy. For this reason, a number of noninvasive tests have been developed-including first-trimester risk assessment at 11 to 14 weeks, maternal serum analyte (quad) screening at 15 to 20 weeks, and sonographic fetal structural survey at 18 to 22 weeks-all of which are designed to give a woman an adjusted (more accurate) estimate of having an aneuploid fetus using as baseline her a priori age-related risk. Ultrasound and maternal serum analysis are considered screening procedures and both require follow up by CVS or amniocentesis in screen-positive cases for a definitive diagnosis of a chromosome abnormality in the fetus. The ability to isolate fetal cells and fetal DNA from maternal blood during pregnancy has opened up exciting opportunities for improved noninvasive prenatal testing (NIPT). Direct analysis of fetal cells from maternal circulation has been challenging given the scarcity of fetal cells in maternal blood (1:10,000-1:1,000,000) and the focus has shifted to the analysis of cell-free fetal DNA, which is found at a concentration almost 25 times higher than that

  15. Prenatal 2-dimensional and 3-dimensional ultrasonography diagnosis and autoptic findings of isolated ectopia cordis.

    Science.gov (United States)

    Bianca, S; Bartoloni, G; Auditore, S; Reale, A; Tetto, C; Ingegnosi, C; Pirruccello, B; Ettore, G

    2006-01-01

    Ectopia cordis is a very rare congenital malformation, commonly associated with intracardiac anomalies. It is due to a defect in fusion of the anterior chest wall resulting in an extrathoracic location of the heart. We report prenatal 2-dimensional (2D) and 3D ultrasonography diagnosis and postnatal autoptic findings of an isolated ectopia cordis with tricuspid atresia. Ectopia cordis prenatal diagnosis is easily made with ultrasound by visualizing the heart outside the thoracic cavity. 3D ultrasonography may add more detailed visualization of the heart anomaly even if the 2D ultrasonography alone permits the prenatal diagnosis. Obstetrical management should include a careful search for associated anomalies, especially cardiac, and the assessment of fetal karyotype. As this is considered a sporadic anomaly, the recurrence risk is low and no genetic origin is known.

  16. Prenatal diagnosis of a 7p15-p21 deletion encompassing the TWIST1 gene involved in Saethre-Chotzen syndrome.

    Science.gov (United States)

    Spaggiari, Emmanuel; Aboura, Azzedine; Sinico, Martine; Mabboux, Philippe; Dupont, Céline; Delezoide, Anne-Lise; Guimiot, Fabien

    2012-01-01

    Saethre-Chotzen syndrome is a craniosynostosis syndrome that is rarely diagnosed prenatally. It is caused by cytogenetic deletions or mutations of the TWIST1 gene. We report here a de novo prenatal case with clinically and molecularly well defined Saethre-Chotzen syndrome due to a TWIST1 deletion. This is the first reported case of a deletion encompassing the TWIST1 gene to be diagnosed prenatally. We recommend screening for a deletion of the TWIST1 gene if signs of coronal craniosynostosis with no clear etiology are observed on ultrasound examination.

  17. Diagnóstico prenatal de aberraciones cromosómicas en Costa Rica

    OpenAIRE

    Castro-Volio, Isabel; Jiménez-Torrealba, Judith

    1985-01-01

    Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 1985 Prenatal diagnosis of chromosomal abnormalities stands upon kariotype analysis of amniotic fluid cells grown in vitro, usually prior to the 20th week of gestation. Laboratory activities began during the year of 1984 aiming to culture amniotic fluid cells at INISA laboratories, according to a previously approved protocol. Amniotic fluid samples have been collected through ultrasound guided amniocen...

  18. Prenatal exercise research.

    Science.gov (United States)

    Field, Tiffany

    2012-06-01

    In this review of recent research on prenatal exercise, studies from several different countries suggest that only approximately 40% of pregnant women exercise, even though about 92% are encouraged by their physicians to exercise, albeit with some 69% of the women being advised to limit their exercise. A moderate exercise regime reputedly increases infant birthweight to within the normal range, but only if exercise is decreased in late pregnancy. Lower intensity exercise such as water aerobics has decreased low back pain more than land-based physical exercise. Heart rate and blood pressure have been lower following yoga than walking, and complications like pregnancy-induced hypertension with associated intrauterine growth retardation and prematurity have been less frequent following yoga. No studies could be found on tai chi with pregnant women even though balance and the risk of falling are great concerns during pregnancy, and tai chi is one of the most effective forms of exercise for balance. Potential underlying mechanisms for exercise effects are that stimulating pressure receptors during exercise increases vagal activity which, in turn, decreases cortisol, increases serotonin and decreases substance P, leading to decreased pain. Decreased cortisol is particularly important inasmuch as cortisol negatively affects immune function and is a significant predictor of prematurity. Larger, more controlled trials are needed before recommendations can be made about the type and amount of pregnancy exercise.

  19. Prenatal findings in carpenter syndrome and a novel mutation in RAB23.

    Science.gov (United States)

    Haye, Damien; Collet, Corinne; Sembely-Taveau, Catherine; Haddad, Georges; Denis, Christelle; Soulé, Nathalie; Suc, Annie-Laure; Listrat, Antoine; Toutain, Annick

    2014-11-01

    Carpenter syndrome is caused by mutations of the RAB23 gene. To date, 12 distinct mutations have been identified among 34 patients from 26 unrelated families. We report on the prenatal findings in a fetus with Carpenter syndrome with a novel RAB23 mutation. Cystic hygroma, bowed femora, abnormal skull shape and a complex heart defect were seen on ultrasound scan, and Carpenter syndrome was diagnosed at birth. Craniosynostosis and preaxial hexadactyly of the feet were retrospectively detectable on the fetal CT scan. Sequencing of RAB23 identified a homozygous mutation leading to skipping of exon 6 and premature termination codon (c.481G>C; p.Val161Leufs*16). This observation illustrates the difficulty of prenatal ultrasound diagnosis of Carpenter syndrome. To our knowledge, this diagnosis was suggested on ultrasound scan in only one prior patient, although in five other patients abnormal skull shape and variable findings, mainly limb anomalies including bowed femora in one case, were described during the pregnancy. Heart defect and bowed femora are rare postnatal findings. The diagnosis of Carpenter syndrome should therefore be considered on prenatal imaging in cases of bowed femora and/or cardiac defect associated with abnormal skull shape.

  20. Prenatal Testing: Is It Right for You?

    Science.gov (United States)

    Healthy Lifestyle Pregnancy week by week Prenatal testing, including screening and diagnostic tests, can provide valuable information about your baby's ... 2015 Original article: http://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/prenatal-testing/art- ...

  1. Prenatal diagnosis of meconium ileus and meconium peritonitis: Indications for cystic fibrosis testing

    Directory of Open Access Journals (Sweden)

    Egić Amira

    2011-01-01

    Full Text Available Introduction. More recently, the regions of increased abdominal echogenicity such as echogenic bowel, meconium ileus and meconium peritonitis have been associated with an increased prevalence of a variety of unfavourable outcomes including chromosomal abnormalities, cytomegalovirus infection, intestinal obstruction, anorectal malformations and cystic fibrosis. Earlier prenatal examinations of these severe autosomal recessive diseases had been suggested only to families with history of cystic fibrosis. Recently, systemic examination has been introduced by ultrasound with bowel hyperechogenicity where the fetus is the index case for genetic disease. Risk for cystic fibrosis with this ultrasonography findings ranges from 0-33%. Outline of Cases. Two patients are presented, aged 24 and 29 years, both primigravide. The first one had ultrasonography finding of meconium peritonitis revealed at the 37th week of gestation and the other meconium ileus revealed on ultrasonography at the 29th week of gestation. Both patients had prenatal testing of foetal blood obtained by cordocenthesis, both had normal kariotype and were negative for cytomegalovirus infection. Parental DNA testing for the 2nd patient showed that parents were not carriers for the 29 most frequent mutations. Both neonates had intestinal obstruction, underwent surgery and early postoperative course was normal. Hystopathological finding suggested a possibility of cystic fibrosis for the 1st patient, but parents did not want to be tested and for the 2nd one congenital bowel stenosis as a cause of intestinal obstruction. Conclusion. Ultrasonographic echogenic bowel is an indication for invasive procedures for foetal blood testing for chromosomal abnormalities, congenital infections and parental testing for cystic fibrosis. Only if parental heterozygosity is proven foetus should be tested.

  2. Neurodevelopmental Outcomes of Prenatal Stress

    Directory of Open Access Journals (Sweden)

    M. Genco Usta

    2012-03-01

    Full Text Available The influence of prenatal stress on psychopathology has been observed in many animal and human studies. In many studies, stress during prenatal period has been shown to result in negative feedback dysregulation and hyperactivity of hypothalamo-pituitary-adrenocortical axis. Prenatal stres also may cause increased risk of birth complications, startle or distress in response to novel and surprising stimuli during infancy; lower Full Scale IQs, language abilities and attention deficiency in period of 3-5 years; increased risk of attention deficit hyperactivity syndrome, anxiety symptoms, depressive disorder and impulsivity during adolescence. Additionally, timing of prenatal stress is also important and 12-22 weeks of gestation seems to be the most vulnerable period. The results underline the need for early prevention and intervention programs for highly anxious women during pregnancy. Administration of prenatal stress monitoring to public health programs or removing pregnant women who have been exposed to life events such as natural disaster, terror attack to secure areas that provide basic needs may be crucial.

  3. Ultrasound in Space Medicine

    Science.gov (United States)

    Dulchavsky, Scott A.; Sargsyan, A.E.

    2009-01-01

    This slide presentation reviews the use of ultrasound as a diagnostic tool in microgravity environments. The goals of research in ultrasound usage in space environments are: (1) Determine accuracy of ultrasound in novel clinical conditions. (2) Determine optimal training methodologies, (3) Determine microgravity associated changes and (4) Develop intuitive ultrasound catalog to enhance autonomous medical care. Also uses of Ultrasound technology in terrestrial applications are reviewed.

  4. Three-Year Follow-Up of a Prenatally Ascertained Apparently Non-Mosaic sSMC(10): Delineation of a Non-Critical Region.

    Science.gov (United States)

    Barranco, Laura; Costa, Marta; Lloveras, Elisabet; Ordóñez, Elena; Maiz, Nerea; Hernando, Cristina; Villa, Olaya; Cirigliano, Vincenzo; Plaja, Alberto

    2015-01-01

    Small supernumerary marker chromosomes (sSMC) originating from chromosome 10 are rare and usually found in mosaic form. We present a de novo apparently non-mosaic sSMC(10) prenatally diagnosed in amniotic fluid and postnatally confirmed in peripheral blood. Characterization by array-CGH showed a pericentromeric duplication of 7.1 Mb of chromosome 10. The fetus did not show ultrasound abnormalities, and a normal female phenotype was observed during a 3-year postnatal follow-up. The absence of phenotypic abnormalities in the present case provides evidence of a non-critical pericentromeric region in 10p11.21q11.1 (hg19 35,355,570-42,448,569) associated with a duplication. © 2016 S. Karger AG, Basel.

  5. ULTRASOUND APPLICATION FOR TREATMENT OF ONCOLOGICAL DISEASES

    Directory of Open Access Journals (Sweden)

    V. Minchenya

    2012-01-01

    Full Text Available The paper proposes methods for treatment of oncological diseases while applying ultrasound as an independent method and modifier of radiation therapy.Experimental and clinical investigations show effectiveness of ultrasound as an independent remedy against malignant tumors and its usage in combination with other anti-tumor agents. However combination effect of ultrasound and radiation on malignant neoplasms and mechanisms of radiation-sensitizing action of low-frequency ultrasonic radiation is still understudied. Influence of ultrasound input direction in malignant tumor zone has not been investigated yet and there are no rational designs of waveguides for controllable vibration impact on skin neoplasms.

  6. Update on prenatal care.

    Science.gov (United States)

    Zolotor, Adam J; Carlough, Martha C

    2014-02-01

    Many elements of routine prenatal care are based on tradition and lack a firm evidence base; however, some elements are supported by more rigorous studies. Correct dating of the pregnancy is critical to prevent unnecessary inductions and to allow for accurate treatment of preterm labor. Physicians should recommend folic acid supplementation to all women as early as possible, preferably before conception, to reduce the risk of neural tube defects. Administration of Rho(D) immune globulin markedly decreases the risk of alloimmunization in an RhD-negative woman carrying an RhD-positive fetus. Screening and treatment for iron deficiency anemia can reduce the risks of preterm labor, intrauterine growth retardation, and perinatal depression. Testing for aneuploidy and neural tube defects should be offered to all pregnant women with a discussion of the risks and benefits. Specific genetic testing should be based on the family histories of the patient and her partner. Physicians should recommend that pregnant women receive a vaccination for influenza, be screened for asymptomatic bacteriuria, and be tested for sexually transmitted infections. Testing for group B streptococcus should be performed between 35 and 37 weeks' gestation. If test results are positive or the patient has a history of group B streptococcus bacteriuria during pregnancy, intrapartum antibiotic prophylaxis should be administered to reduce the risk of infection in the infant. Intramuscular or vaginal progesterone should be considered in women with a history of spontaneous preterm labor, preterm premature rupture of membranes, or shortened cervical length (less than 2.5 cm). Screening for diabetes should be offered using a universal or a risk-based approach. Women at risk of preeclampsia should be offered low-dose aspirin prophylaxis, as well as calcium supplementation if dietary calcium intake is low. Induction of labor may be considered between 41 and 42 weeks' gestation.

  7. [Communication skills for prenatal counselling].

    Science.gov (United States)

    Bitzer, J; Tschudin, S; Holzgreve, W; Tercanli, S

    2007-04-18

    Prenatal counselling is characterized by specific characteristics: A):The communication is about the values of the pregnant woman and her relationship with the child to be. B) The communication deals with patient's images and emotions. C) It is a communication about risks, numbers and statistics. D) Physician and patient deal with important ethical issues. In this specific setting of prenatal diagnosis and care physicians should therefore learn to apply basic principles of patient-centred communication with elements of non directive counselling, patient education and shared decision making. These elements are integrated into a process which comprises the following "steps": 1. Clarification of the patient's objectives and the obstetrician's mandate. 2. The providing of individualized information and education about prenatal tests and investigations. 3. Shared decision making regarding tests and investigations 4. Eventually Breaking (bad, ambivalent) news. 5. Caring for patients with an affected child.

  8. [Normative prenatal evaluation at a philanthropic maternity hospital in São Paulo].

    Science.gov (United States)

    Corrêa, Claudia Regina Hostim; Bonadio, Isabel Cristina; Tsunechiro, Maria Alice

    2011-12-01

    This cross-sectional study counted with the participation of 301 pregnant women seen in 2009 at a philanthropic maternity hospital in the city of São Paulo (a prenatal support program named Pré-Natal do Amparo Maternal - PN-AM). The objectives of this study were to evaluate the prenatal care according to the initial gestational age, the number of appointments that were held, the continuity of the assistance, and relate the appropriateness with the socio-demographic, obstetric and local variables of the initial prenatal care. The analysis criteria used was initiating prenatal care before 120 days of gestation and attending at least six appointments. The relationship between the variables was analyzed using the Chi-Square Test. Results showed that 41.5% of the pregnant women initiated prenatal care at another health care service and transferred spontaneously to the PN-AM; 74.1% initiated the prenatal care early and 80.4% attended at least six appointments; 63.1% met both criteria simultaneously. Appropriate prenatal care showed a statistically significant difference for mother's age, steady partner, employment, place of residence, having a companion during the appointment and place where prenatal care was initiated.

  9. Factors Influencing the Use of Prenatal Care: A Systematic Review

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available Background & aim: Prenatal care is a key strategy for achieving public health goals, primary healthcare objectives, and the Millennium Development Goals. The aim of this study was to investigate the factors influencing the use of prenatal care services in order to design suitable interventions and promote the use of these services. Methods:In this systematic quantitative literature review, studies published in years 2010-2014 were evaluated. For this purpose, two international electronic databases, i.e., Scopus and PubMed, were explored to find English-language articles by using relevant keywords; moreover, the reference lists of the articles were hand-searched. We reviewed all cross-sectional and prospective studies, which focused on factors associated with the use of prenatal care services within the specified period of time. Results: In total, 17 relevant articles were included in our review. The results showed that late initiation and inadequate use of prenatal care services are independently associated with multiple variables, including demographic characteristics, socioeconomic factors, predisposing cultural and religious factors, social support, factors related to healthcare providers, women’s awareness and attitude, unintended pregnancy, high-risk medical or obstetric history, and health behaviors. Conclusion: Based on the literature review, proper use of prenatal care cannot be achieved merely by establishing healthcare centers. Utilization of maternal health services may be achieved and improved via developing socioeconomic factors and addressing patients' basic needs including education and financial independence.

  10. The results of cytogenetic analyses in prenatal diagnosis

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    Jovanović-Privrodski Jadranka

    2007-01-01

    Full Text Available Introduction. G-banding and other classical cytogenetic methods are still in use, together with molecular cytogenetic techniques such as FISH (Fluorescence In Situ Hybridization and SKY (Spectral Karyotyping. Material and methods. This retrospective study evaluated clinical data on individuaols seeking genetic counseling over a 15-year period (1992 - 2007 at the Medical Genetic Center, Child and Youth Health Care Institute of Vojvodina in Novi Sad. The study included 37.191 genetic counselings, and 20.607 prenatal analyses (amniocentesis and cordocentesis. Results Over a 15-year period (1992 - 2007 17.937 amniotic fluid samples were analyzed and 274 abnormal karyotypes were found; out of 2.670 fetal blood samples, there were 78 abnormal karyotypes. During a 15-year period, prenatal diagnosis, using amniocentesis and/or cordocentesis, showed 352 fetuses with chromosomal aberrations. Discussion. On average, over the past 15-year period, 8% of pregnancies were controlled with invasive prenatal procedures. The percentage has changed; in fact, it is increasing from year to year. In 1992, only 0.82% (N=139/17000 of pregnant women in Vojvodina underwent invasive prenatal procedures, and in 2006 the rate increased to 15.65% (N=2660/17000. Conclusion. It is necessary to improve and promote the possibilities of genetic counseling and invasive prenatal diagnosis in order to prevent the occurrence of chromosomal aberrations and other genetic diseases.

  11. Molecular confirmation of nine cases of Cornelia de Lange syndrome diagnosed prenatally.

    Science.gov (United States)

    Dempsey, M A; Knight Johnson, A E; Swope, B S; Moldenhauer, J S; Sroka, H; Chong, K; Chitayat, D; Briere, L; Lyon, H; Palmer, N; Gopalani, S; Siebert, J R; Lévesque, S; Leblanc, J; Menzies, D; Haverfield, E; Das, S

    2014-02-01

    Cornelia de Lange syndrome (CdLS) is characterized by distinct facial features, growth retardation, upper limb reduction defects, hirsutism, and intellectual disability. NIPBL mutations have been identified in approximately 60% of patients with CdLS diagnosed postnatally. Prenatal ultrasound findings include upper limb reduction defects, intrauterine growth restriction, and micrognathia. CdLS has also been associated with decreased PAPP-A and increased nuchal translucency (NT). We reviewed NIPBL sequence analysis results for 12 prenatal samples in our laboratory to determine the frequency of mutations in our cohort. This retrospective study analyzed data from all 12 prenatal cases with suspected CdLS, which were received by The University of Chicago Genetic Services Laboratories. Diagnostic NIPBL sequencing was performed for all samples. Clinical information was collected from referring physicians. NIPBL mutations were identified in 9 out of the 12 cases prenatally (75%). Amongst the NIPBL mutation-positive cases with clinical information available, the most common findings were upper limb malformations and micrognathia. Five patients had NT measurements in the first trimester, of which four were noted to be increased. We demonstrate that prenatally-detected phenotypes of CdLS, particularly severe micrognathia and bilateral upper limb defects, are associated with an increased frequency of NIPBL mutations. © 2013 John Wiley & Sons, Ltd.

  12. Prenatal diagnosis of foetuses with congenital abnormalities and duplication of the MECP2 region.

    Science.gov (United States)

    Fu, Fang; Liu, Huan-ling; Li, Ru; Han, Jin; Yang, Xin; Min, Pan; Zhen, Li; Zhang, Yong-ling; Xie, Gui-e; Lei, Ting-ying; Li, Yan; Li, Jian; Li, Dong-zhi; Liao, Can

    2014-08-10

    MECP2 duplication results in a well-recognised syndrome in 100% of affected male children; this syndrome is characterised by severe neurodevelopmental disabilities and recurrent infections. However, no sonographic findings have been reported for affected foetuses, and prenatal molecular diagnosis has not been possible for this disease due to lack of prenatal clinical presentation. In this study, we identified a small duplication comprising the MECP2 and L1CAM genes in the Xq28 region in a patient from a family with severe X-linked mental retardation and in a prenatal foetus with brain structural abnormalities. Using high-resolution chromosome microarray analysis (CMA) to screen 108 foetuses with congenital structural abnormalities, we identified additional three foetuses with the MECP2 duplication. Our study indicates that ventriculomegaly, hydrocephalus, agenesis of the corpus callosum, choroid plexus cysts, foetal growth restriction and hydronephrosis might be common ultrasound findings in prenatal foetuses with the MECP2 duplication and provides the first set of prenatal cases with MECP2 duplication, the ultrasonographic phenotype described in these patients will help to recognise the foetuses with possible MECP2 duplication and prompt the appropriate molecular testing.

  13. PRENATAL DIAGNOSIS IN ORGANIC ACIDEMIA

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    Hedieh SANEIFARD

    2012-03-01

    Full Text Available Organic acidemias are the group of metabolic disorders which define by high anion gap metabolic acidosis, hypo or hyperglycemia & hyperammonemia.Because of the severity of disease in children and its fatality in severe form of disease and also need for life long treatment, prenatal diagnosis is an important diagnostic tool.Three approaches to prenatal diagnosis may be possible, including measurement of analytes in amniotic fluid or use of cells obtained by Choronic Villus sampling (CVS or amniocentesis to either assay enzyme activity or extract DNA for molecular genetic testing.Biochemical genetic testing: Prenatal diagnosis for pregnancies at increased risk for propionic acidemia, methylmalonic acidemia, biotin-unresponsive3-methylcrotonyl-CoA carboxylase deficiency, glutaric acidemia type 1, ketothiolase deficiency, methylmalonic aciduria and homocystinuria, cblC type, and isovaleric acidemia is possible by analysis of amniotic fluid if highly accurate quantitative methods are used to measure the appropriate analytes. Amniocentesis is usually performed at approximately 15 to 18 weeks gestation.Prenatal diagnosis for pregnancies at increased risk for MSUD is possible by measurement of enzyme activity in fetal cells obtained by chorionic villous sampling(CVS at approximately ten to 12 weeks gestation or amniocentesis usually performed at approximately 15 to 18 weeks gestation.(If cells from CVS are used, extreme care must be taken to assure that they are fetal rather than maternal cells.Molecular genetic testing:Prenatal diagnosis for pregnancies at increased risk for all disorders is possible by analysis of DNA extracted from fetal cells obtained by amniocentesis usually performed at approximately 15 to 18 weeks of gestation or chorionic villous sampling (CVS at approximately ten to 12 weeks of gestation. Both disease-causing allels of an affected family member must be identified before prenatal testing.Preimplantation genetic diagnosis (PGD

  14. Prenatal prediction of pulmonary hypoplasia.

    Science.gov (United States)

    Triebwasser, Jourdan E; Treadwell, Marjorie C

    2017-03-15

    Pulmonary hypoplasia, although rare, is associated with significant neonatal morbidity and mortality. Conditions associated with pulmonary hypoplasia include those which limit normal thoracic capacity or movement, including skeletal dysplasias and abdominal wall defects; those with mass effect, including congenital diaphragmatic hernia and pleural effusions; and those with decreased amniotic fluid, including preterm, premature rupture of membranes, and genitourinary anomalies. The ability to predict severe pulmonary hypoplasia prenatally aids in family counseling, as well as obstetric and neonatal management. The objective of this review is to outline the imaging techniques that are widely used prenatally to assess pulmonary hypoplasia and to discuss the limitations of these methods.

  15. Prenatal diagnosis of cystic fibrosis: 10-years experience.

    Science.gov (United States)

    Hadj Fredj, S; Ouali, F; Siala, H; Bibi, A; Othmani, R; Dakhlaoui, B; Zouari, F; Messaoud, T

    2015-06-01

    We present in this study our 10years experience in prenatal diagnosis of cystic fibrosis performed in the Tunisian population. Based on family history, 40 Tunisian couples were selected for prenatal diagnosis. Fetal DNA was isolated from amniotic fluid collected by transabdominal amniocentesis or from chronic villi by transcervical chorionic villus sampling. The genetic analysis for cystic fibrosis mutations was performed by denaturant gradient gel electrophoresis and denaturing high-pressure liquid phase chromatography. We performed microsatellites analysis by capillary electrophoresis in order to verify the absence of maternal cell contamination. Thirteen fetuses were affected, 21 were heterozygous carriers and 15 were healthy with two normal alleles of CFTR gene. Ten couples opted for therapeutic abortion. The microsatellites genotyping showed the absence of contamination of the fetal DNA by maternal DNA in 93.75%. Our diagnostic strategy provides rapid and reliable prenatal diagnosis at risk families of cystic fibrosis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  16. Radiological evaluation of the fetal face using three-dimensional ultrasound imaging

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    Bäumler M

    2012-12-01

    Full Text Available Marcel Bäumler,1–3 Michèle Bigorre,1,4 Jean-Michel Faure1,51CHU Montpellier, Centre de Compétence des Fentes Faciales, Hôpital Lapeyronie, Montpellier, 2Clinique du Parc, Imagerie de la Femme, Castelnau-le-Lez, 3Cabinet de Radiologie du Trident, Lunel, 4CHU Service de Chirurgie Plastique Pédiatrique, Hôpital Lapeyronie, Montpellier, 5CHU Montpellier, Service de Gynécologie-Obstétrique, Hôpital Arnaud de Villeneuve, Montpellier, FranceAbstract: This paper reviews screening and three-dimensional diagnostic ultrasound imaging of the fetal face. The different techniques available for analyzing biometric and morphological items of the profile, eyes, ears, lips, and hard and soft palate are commented on and briefly compared with the respective bi-dimensional techniques. The available literature supports the use of three-dimensional ultrasound in difficult prenatal diagnostic conditions because of its diagnostic accuracy, enabling improved safety of perinatal care. Globally, a marked increase has been observed in the accuracy of three-dimensional ultrasound in comparison with the bi-dimensional approach. Because there is no consensus about the performance of the different three-dimensional techniques, future studies are needed in order to compare them and to find the best technique for analysis of each of the respective facial elements. Universal prenatal standards may integrate these potential new findings in the future. At this time, the existing guidelines for prenatal facial screening should not be changed.Keywords: prenatal three-dimensional ultrasound, prenatal screening, prenatal diagnosis, cleft lip and palate, fetal profile, retrognathism

  17. ATTENTION FUNCTIONING IN CHILDREN WITH PRENATAL DRUG EXPOSURE.

    Science.gov (United States)

    Jaeger, Dominique A; Suchan, Boris; Schölmerich, Axel; Schneider, Dominik T; Gawehn, Nina

    2015-01-01

    Children born to drug abusers are exposed to teratogenic influences on intrauterine brain development and undergo postnatal withdrawal. We investigated the interplay of different domains and levels of attention functioning in 24 prenatally exposed and 25 nonexposed children who were 5 to 6 years old. Assessment included parent ratings and neuropsychological and electrophysiological methods. Exposed children had a higher prevalence of attention deficit hyperactivity symptoms, tended to have poorer performance in an attention test battery, and showed EEG alterations in P3 and N2c. Findings suggest long-term effects of prenatal drug exposure on specific domains and on different levels of attention functioning.

  18. Prenatal Diagnosis of a Fetus with de novo Supernumerary Ring Chromosome 16 Characterized by Array Comparative Genomic Hybridization

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    Pietro Cignini

    2011-09-01

    Full Text Available A fetus with de novo ring chromosome 16 is presented. At 20 weeks' gestation, ultrasound examination demonstrated bilateral clubfoot, bilateral renal pyelectasis, hypoplasia of the corpus callosum, and transposition of the great vessel. Amniocentesis was performed. Chromosome analysis identified a ring chromosome 16 [47,XY,r(16] and array comparative genomic hybridization (a-CGH demonstrated that the ring included the euchromatic portion 16p11.2. Postmortem examination confirmed prenatal findings. This is the first case of de novo ring chromosome 16 diagnosed prenatally with a new phenotypic pattern and also reinforces the importance of offering amniocentesis with a-CGH if fetal anomalies are detected.

  19. Children's (Pediatric) Abdominal Ultrasound Imaging

    Medline Plus

    Full Text Available ... are the limitations of Abdominal Ultrasound Imaging? What is Abdominal Ultrasound Imaging? Ultrasound is safe and painless, ... through the blood vessels. top of page How is the procedure performed? For most ultrasound exams, you ...

  20. Ultrasound of the Thyroid Gland

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Ultrasound - Thyroid Thyroid ultrasound uses sound waves to produce pictures ... the Thyroid? What is an Ultrasound of the Thyroid? Ultrasound is safe and painless, and produces pictures ...

  1. Ultrasound-Guided Breast Biopsy

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound-Guided Breast Biopsy An ultrasound-guided breast biopsy ... limitations of Ultrasound-Guided Breast Biopsy? What is Ultrasound-Guided Breast Biopsy? Lumps or abnormalities in the ...

  2. Children's (Pediatric) Abdominal Ultrasound Imaging

    Medline Plus

    Full Text Available ... of page What are some common uses of the procedure? Abdominal ultrasound imaging is performed to evaluate ... for ultrasound examinations. top of page What does the ultrasound equipment look like? Ultrasound scanners consist of ...

  3. Cord blood unit bankability can be predicted by prenatal sonographic parameters.

    Science.gov (United States)

    Cobellis, L; Castaldi, M A; Trabucco, E; Imparato, G; Perricone, F; Frega, V; Signoriello, G; Colacurci, N

    2013-10-01

    To identify possible sonographic prenatal parameters and postnatal parameters in order to obtain more bankable cord blood units (CBUs) containing a high number of primitive progenitor cells, allowing CBUs to be used as a source of haematopoietic progenitors for clinical transplantation. Prospective study undertaken in the Department of Gynaecology, Obstetrics and Reproductive Science, Second University of Naples, Italy. In total, 219 unrelated CBU donors were enrolled. Ultrasound parameters (biparietal diameter, head circumference, abdominal circumference, femur length, estimation of fetal weight, umbilical artery pulsatility index), collected at hospital admission, together with birth weight and placental weight, were correlated with bankable CBU parameters (CBU volume, total nucleated cell count, CD34+ cell count). Femur length and abdominal circumference correlated positively with bankable CBUs. Receiver operating curve analysis showed that these parameters can identify bankable CBUs. This is the first prospective study to show the relationship between ultrasonographic fetal parameters at term and the possibility of obtaining high-quality CBUs. As such, cord blood banking could be improved worldwide by performing low-cost ultrasonographic scans. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  4. Ultrasound in Arthritis.

    Science.gov (United States)

    Sudoł-Szopińska, Iwona; Schueller-Weidekamm, Claudia; Plagou, Athena; Teh, James

    2017-09-01

    Ultrasound is currently performed in everyday rheumatologic practice. It is used for early diagnosis, to monitor treatment results, and to diagnose remission. The spectrum of pathologies seen in arthritis with ultrasound includes early inflammatory features and associated complications. This article discusses the spectrum of ultrasound features of arthritides seen in rheumatoid arthritis and other connective tissue diseases in adults, such as Sjögren syndrome, lupus erythematosus, dermatomyositis, polymyositis, and juvenile idiopathic arthritis. Ultrasound findings in spondyloarthritis, osteoarthritis, and crystal-induced diseases are presented. Ultrasound-guided interventions in patients with arthritis are listed, and the advantages and disadvantages of ultrasound are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Prenatal care effectiveness and utilization in Brazil.

    Science.gov (United States)

    Wehby, George L; Murray, Jeffrey C; Castilla, Eduardo E; Lopez-Camelo, Jorge S; Ohsfeldt, Robert L

    2009-05-01

    The impact of prenatal care use on birth outcomes has been understudied in South American countries. This study assessed the effects of various measures of prenatal care use on birth weight (BW) and gestational age outcomes using samples of infants born without and with common birth defects from Brazil, and evaluated the demand for prenatal care. Prenatal visits improved BW in the group without birth defects through increasing both fetal growth rate and gestational age, but prenatal care visits had an insignificant effect on BW in the group with birth defects when adjusting for gestational age. Prenatal care delay had no effects on BW in both infant groups but increased preterm birth risk in the group without birth defects. Inadequate care versus intermediate care also increased LBW risk in the group without birth effects. Quantile regression analyses revealed that prenatal care visits had larger effects at low compared with high BW quantiles. Several other prenatal factors and covariates such as multivitamin use and number of previous live births had significant effects on the studied outcomes. The number of prenatal care visits was significantly affected by several maternal health and fertility indicators. Significant geographic differences in utilization were observed as well. The study suggests that more frequent use of prenatal care can increase BW significantly in Brazil, especially among pregnancies that are uncomplicated with birth defects but that are at high risk for low birth weight. Further research is needed to understand the effects of prenatal care use for pregnancies that are complicated with birth defects.

  6. Hypertrophic Cardiomyopathy due to Mitochondrial Disease: Prenatal Diagnosis, Management, and Outcome

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    Lutgardo García-Díaz

    2013-01-01

    Full Text Available A case of prenatally diagnosed fetal hypertrophic cardiomyopathy is reported. The mother was referred to our department at 37 weeks' gestation because of suspected congenital heart disease. Prenatal echocardiography showed biventricular hypertrophy and pericardial effusion, without additional abnormalities. Postnatal echocardiography confirmed prenatal diagnosis. Neonatal EKG showed biventricular hypertrophy and Wolff-Parkinson-White syndrome. Skeletal muscle biopsy was consistent with mitochondrial oxidative phosphorylation defect involving a combined defect of respiratory complexes I and IV. Echocardiographic followup during the first year of life showed progressive regression of hypertrophy and evolution to left ventricular myocardial noncompaction.

  7. Different information by MRI compare to ultrasound in fetal intracranial space occupying lesions.

    Science.gov (United States)

    Xia, Wei; Kasprian, Gregor; Hu, Daoyu; Xiao, Peng; Yang, Wenzhong; Chen, Xinlin

    2017-07-10

    The purpose of this study was to evaluate the value of prenatal magnetic resonance imaging (MRI) in characterizing fetal intracranial space occupying lesions in comparison to prenatal ultrasound. This retrospective study included 50 fetuses (mean age 26 years, mean gestational weeks 31 + 1 GW) with intracranial space occupying lesions, suspected by prenatal screening ultrasound. T2-weighted, T1-weighted, SSFP, and diffusion-weighted sequences of the fetal brain were obtained on a 1.5 T unit. Pathology (n = 5), postmortem MRI (n = 3), or postnatal US (n = 42) was available as standard of reference. The fetal MRI provided correct diagnosis in 49 cases (98%), while 35 (70%) by ultrasound, and MRI failed in 1 case (2%), while ultrasound failed in 15 cases (30%). Fetal MR and ultrasound were concordant in 35 of 50 cases (70%), completely discordant in 4 (8%), and partially discordant in 11 (22%) cases. MRI could provide detailed information about the minor lesions, such as focal hemorrhage and periventricular nodules. Meanwhile, it could provide whole view of the lesion in order to delineate the surrounding anatomical structure. But there are still some limitations of its soft-tissue resolution in a case with teratoma; more effort is needed to improve the sequences.

  8. First-trimester screening for trisomy 21 combining biochemistry and ultrasound at individually optimal gestational ages. An interventional study.

    Science.gov (United States)

    Borrell, Antoni; Casals, Elena; Fortuny, Albert; Farre, M Teresa; Gonce, Anna; Sanchez, Aurora; Soler, Anna; Cararach, Vicençc; Vanrell, Joan A

    2004-07-01

    To assess the effectiveness of the Combined Test in the prenatal detection of trisomy 21 in the general pregnant population using a new timing for the screening approach. First-trimester maternal serum biochemical markers (pregnancy-associated plasma protein-A and free-beta hCG) were determined in maternal serum at 7 to 12 weeks. Fetal nuchal translucency and gestational age were assessed at the 10- to 14-week ultrasound scan. A combined risk was estimated and delivered to the women the same day. When the risk was 1:250 or above, chorionic villus sampling was offered. Mean gestational age at biochemistry was 9.4 weeks, being 12.3 at ultrasound. In the 2780 studied pregnancies with a complete follow-up, observed detection rates were 88% (7/8) for trisomy 21 and 75% (3/4) for trisomy 18, with a 3.3% (92/2765) false-positive rate. The Combined Test, assessing biochemistry and ultrasound at individually optimal ages in the first trimester, showed an 88% detection rate for trisomy 21 with a remarkably reduced false-positive rate (3.3%). Copyright 2004 John Wiley and Sons, Ltd.

  9. A Case of Ultrasound Diagnosis of Fetal Hiatal Hernia in Late Third Trimester of Pregnancy

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    Stefania Di Francesco

    2015-01-01

    Full Text Available Congenital hiatal hernia is a condition characterized by herniation of the abdominal organs, most commonly the stomach, through a physiological but overlax esophageal hiatus into the thoracic cavity. Prenatal diagnosis of this anomaly is unusual and only eight cases have been reported in the literature. In this paper we describe a case of congenital hiatal hernia that was suspected at ultrasound at 39 weeks’ gestation, on the basis of a cystic mass in the posterior mediastinum, juxtaposed to the vertebral body. Postnatal upper gastrointestinal tract series confirmed the prenatal diagnosis. Postnatal management was planned with no urgency. Hiatal hernia is not commonly considered in the differential diagnosis of fetal cystic chest anomalies. This rare case documents the importance of prenatal diagnosis of this anomaly for prenatal counseling and postnatal management.

  10. Prenatal diagnosis of congenital diseases

    NARCIS (Netherlands)

    M.F. Niermeijer (Martinus)

    1975-01-01

    textabstractPrenatal diagnosis of a number of congenital diseases is possible by amniocentesis in the 14th - 16th week of pregnancy and subsequent analysis of cultured amniotic fluid cells or amniotic fluid supernatant. Parents at risk for a child with a chromosomal disorder, an X-linked disease, a

  11. Prenatal stressors in rodents: Effects on behavior

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    Marta Weinstock

    2017-02-01

    Full Text Available The current review focuses on studies in rodents published since 2008 and explores possible reasons for any differences they report in the effects of gestational stress on various types of behavior in the offspring. An abundance of experimental data shows that different maternal stressors in rodents can replicate some of the abnormalities in offspring behavior observed in humans. These include, anxiety, in juvenile and adult rats and mice, assessed in the elevated plus maze and open field tests and depression, detected in the forced swim and sucrose-preference tests. Deficits were reported in social interaction that is suggestive of pathology associated with schizophrenia, and in spatial learning and memory in adult rats in the Morris water maze test, but in most studies only males were tested. There were too few studies on the novel object recognition test at different inter-trial intervals to enable a conclusion about the effect of prenatal stress and whether any deficits are more prevalent in males. Among hippocampal glutamate receptors, NR2B was the only subtype consistently reduced in association with learning deficits. However, like in humans with schizophrenia and depression, prenatal stress lowered hippocampal levels of BDNF, which were closely correlated with decreases in hippocampal long-term potentiation. In mice, down-regulation of BDNF appeared to occur through the action of gene-methylating enzymes that are already increased above controls in prenatally-stressed neonates. In conclusion, the data obtained so far from experiments in rodents lend support to a physiological basis for the neurodevelopmental hypothesis of schizophrenia and depression.

  12. Three- and four-dimensional ultrasound in fetal echocardiography: an up-to-date overview.

    Science.gov (United States)

    Adriaanse, B M E; van Vugt, J M G; Haak, M C

    2016-09-01

    Congenital heart diseases (CHD) are the most commonly overlooked lesions in prenatal screening programs. Real-time two-dimensional ultrasound (2DUS) is the conventionally used tool for fetal echocardiography. Although continuous improvements in the hardware and post-processing software have resulted in a good image quality even in late first trimester, 2DUS still has its limitations. Four-dimensional ultrasound with spatiotemporal image correlation (STIC) is an automated volume acquisition, recording a single three-dimensional (3D) volume throughout a complete cardiac cycle, which results in a four-dimensional (4D) volume. STIC has the potential to increase the detection rate of CHD. The aim of this study is to provide a practical overview of the possibilities and (dis)advantages of STIC. A review of literature and evaluation of the current status and clinical value of 3D/4D ultrasound in prenatal screening and diagnosis of congenital heart disease are presented.

  13. Diagnosis of spina bifida on ultrasound: always termination?

    Science.gov (United States)

    Trudell, Amanda S; Odibo, Anthony O

    2014-04-01

    Open spina bifida is a non-lethal fetal anomaly. Significant advances in the prevention, diagnosis and treatment of open spina bifida have been made over the past 75 years. The most significant strategy for the prevention of open spina bifida has been with folic acid supplementation; however, further investigation into the complicated role that genetics and the environment play in metabolism are coming to light. Ultrasound is the gold standard diagnostic tool for spina bifida. Three-dimensional ultrasound and magnetic resonance imaging are also beginning to play a role in the characterisation of the open spina bifida spinal lesion. Lesion level has been closely correlated to short and long-term outcomes, and prenatal characterisation of lesion level on ultrasound is important for patient counselling. Long-term outcomes of people living with spina bifida are available and should be used for non-directive patient counselling about pregnancy choices for women with open spina bifida.

  14. Prenatal Care: First Trimester Visits

    Science.gov (United States)

    ... mention even sensitive issues, such as domestic abuse, abortion or past drug use. Remember, the information you ... Your health care provider will use a fetal ultrasound to help confirm the date. Physical exam Your ...

  15. Prenatal imprinting by environmental toxicants: really an important issue?

    Directory of Open Access Journals (Sweden)

    Karl Ernst v. Mühlendahl

    2015-06-01

    Full Text Available Prenatal imprinting of sexual behaviour and of other traits by environmental toxicants has been one important topic in the ongoing discussions in environmental medicine. This review of the literature shows that, so far, concrete data are sparse and, in part, contradictory.

  16. The Effectiveness of Prenatal Intervention on Pain and Anxiety ...

    African Journals Online (AJOL)

    ... about the birth.[4]. Over 90% of prenatal stress and anxiety is related to the process ... stress hormones increases and can lead to preterm birth, lack ... Results: The result of this study showed that the parent with a high level of education was more ..... the benefits of educational programs to participants and their newborns ...

  17. [Prenatal diagnostics of chromosomal aberrations Czech Republic: 1994-2007].

    Science.gov (United States)

    Gregor, V; Sípek, A; Sípek, A; Horácek, J '; Langhammer, P; Petrzílková, L; Calda, P

    2009-02-01

    An analysis of prenatal diagnostics efficiency of selected types of chromosomal aberrations in the Czech Republic in 2007. Update of 1994-2007 data according to particular selected diagnoses. Retrospective epidemiological analysis of pre- and postnatal chromosomal aberrations diagnostics and its efficiency. Data on pre- and postnatally diagnosed birth defects in the Czech Republic during 1994-2007 were used. Data on prenatally diagnosed birth defects (and for terminated pregnancies) were collected from particular departments of prenatal diagnostics, medical genetics and ultrasound diagnostics in the Czech Republic, data on birth defects in births from the National Birth Defects Register (Institute for Health Information and Statistics). Total numbers over the period under the study, mean incidences of selected types of chromosomal aberrations and mean prenatal diagnostics efficiencies were analyzed. Following chromosomal aberrations were studied: Down, Edwards, Patau, Turner and Klinefelter syndromes and syndromes 47,XXX and 47,XYY. A relative proportion of Down, Edwards and Patau syndromes as well as other autosomal and gonosomal aberration is presented in figures. Recently, trisomies 13, 18 and 21 present around 70% of all chromosomal aberrations in selectively aborted fetuses, in other pregnancies, "other chromosomal aberrations" category (mostly balanced reciprocal translocations and inversions) present more than 2/3 of all diagnoses. During the period under the study, following total numbers, mean relative incidences (per 10,000 live births, in brackets) and mean prenatal diagnostics efficiency (in %) were found in following chromosomal syndromes: Down syndrome 2,244 (16.58) and 63.37%, Edwards syndrome 521 (3.85) and 79.93%, Patau syndrome 201 (1.49) and 68.87%, Turner syndrome 380 (2.81) and 79.89%, 47,XXX syndrome 61 (0.45) and 59.74%, Klinefelter syndrome 163 (1.20) and 73.65% and 47,XYY syndrome 22 (0.16) and 54.76%. The study gives updated results of

  18. Prenatal/neonatal pathology in two cases of Cornelia de Lange syndrome harboring novel mutations of NIPBL.

    Science.gov (United States)

    Lalatta, Faustina; Russo, Silvia; Gentilin, Barbara; Spaccini, Luigina; Boschetto, Chiara; Cavalleri, Florinda; Masciadri, Maura; Gervasini, Cristina; Bentivegna, Angela; Castronovo, Paola; Larizza, Lidia

    2007-03-01

    This study reviews prenatal findings in two cases with a suspected diagnosis of Cornelia de Lange Syndrome, a multisystem disorder characterized by somatic defects and mental retardation, that were later confirmed by postmortem examination and molecular testing. Although the correlation between the Cornelia de Lange Syndrome genotype and phenotype is still unclear, preliminary data indicate several severe phenotypic features that are likely to be detected prenatally in NIPBL-mutated patients. We report on two prenatal/neonatal cases with unusual pathologic findings indicating Cornelia de Lange Syndrome. The first, with suspected Cornelia de Lange Syndrome after a set of typical dysmorphisms was noted by prenatal ultrasound, was confirmed by a physical examination after termination of the pregnancy. The second was diagnosed neonatally on the basis of typical clinical signs. Medical complications led to death within the first month of life. Molecular analysis of NIPBL, the gene that codes for delangin (a component of the cohesin complex), performed postnatally detected two de novo mutations: a missense change (P2056L) in a highly conserved residue and a nonsense alteration (S2490 replaced by a stop codon). We suggest that early diagnosis of Cornelia de Lange Syndrome would be made much easier by the assemblage of a set of prenatal diagnostic features and criteria in Cornelia de Lange Syndrome cases that have been confirmed by direct physical and molecular examinations. We also suggest that Cornelia de Lange Syndrome genotype-phenotype correlations need to be extended to prenatal cases.

  19. General Ultrasound Imaging

    Medline Plus

    Full Text Available ... flat sections of the body. Advancements in ultrasound technology include three-dimensional (3-D) ultrasound that formats ... also used to: guide procedures such as needle biopsies , in which needles are used to sample cells ...

  20. Medical Ultrasound Imaging.

    Science.gov (United States)

    Hughes, Stephen

    2001-01-01

    Explains the basic principles of ultrasound using everyday physics. Topics include the generation of ultrasound, basic interactions with material, and the measurement of blood flow using the Doppler effect. (Author/MM)