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Sample records for premotor circuit topology

  1. Circuit topology of proteins and nucleic acids.

    Science.gov (United States)

    Mashaghi, Alireza; van Wijk, Roeland J; Tans, Sander J

    2014-09-02

    Folded biomolecules display a bewildering structural complexity and diversity. They have therefore been analyzed in terms of generic topological features. For instance, folded proteins may be knotted, have beta-strands arranged into a Greek-key motif, or display high contact order. In this perspective, we present a method to formally describe the topology of all folded linear chains and hence provide a general classification and analysis framework for a range of biomolecules. Moreover, by identifying the fundamental rules that intrachain contacts must obey, the method establishes the topological constraints of folded linear chains. We also briefly illustrate how this circuit topology notion can be applied to study the equivalence of folded chains, the engineering of artificial RNA structures and DNA origami, the topological structure of genomes, and the role of topology in protein folding.

  2. Robust Topological Terahertz Circuits using Semiconductors

    CERN Document Server

    Bahari, Babak; Kanté, Boubacar

    2016-01-01

    Topological Insulator-based devices can transport electrons/photons at the surfaces of materials without any back reflections, even in the presence of obstacles. Topological properties have recently been studied using non-reciprocal materials such as gyromagnetics or using bianisotropy. However, these effects usually saturate at optical frequencies and limit our ability to scale down devices. In order to implement topological devices that we introduce in this paper for the terahertz range, we show that semiconductors can be utilized via their cyclotron resonance in combination with small magnetic fields. We propose novel terahertz operating devices such as the topological tunable power splitter and the topological circulator. This work opens new perspectives in the design of terahertz integrated devices and circuits with high functionality.

  3. Depth optimization for topological quantum circuits

    Science.gov (United States)

    AlFailakawi, Mohammad; Ahmad, Imtiaz; AlTerkawi, Laila; Hamdan, Suha

    2015-02-01

    Topological quantum computing (TQC) model is one of the most promising models for quantum computation. A circuit implemented under TQC is optimized by reducing its depth due to special construction requirements in such technology. In this work, we propose a hybrid approach that combines a left-edge greedy heuristic with genetic algorithm (GA) to minimize circuit depth through combined line and gate ordering. In our implementation, GA is used to find line ordering, whereas the left edge is used to reduce circuit depth by taking into consideration overlap constraints imposed by line ordering. Moreover, the proposed algorithm can merge gates together realizing circuit with multi-target gates to provide reduced circuit depth. Experimental results on random benchmark circuits show that the proposed algorithm was able to reduce circuit depth by 42 % on average for CNOT circuits, with additional 5 % savings when multi-target optimization is used. Results on RevLib benchmarks revealed a typical enhancement of 21 % and an additional 11 % when multi-target gates are allowed.

  4. Topology Optimization of Building Blocks for Photonic Integrated Circuits

    DEFF Research Database (Denmark)

    Jensen, Jakob Søndergaard; Sigmund, Ole

    2005-01-01

    Photonic integrated circuits are likely candidates as high speed replacements for the standard electrical integrated circuits of today. However, in order to obtain a satisfactorily performance many design prob- lems that up until now have resulted in too high losses must be resolved. In this work...... we demonstrate how the method of topology optimization can be used to design a variety of high performance building blocks for the future circuits....

  5. Time- and Site-Resolved Dynamics in a Topological Circuit

    Directory of Open Access Journals (Sweden)

    Jia Ningyuan

    2015-06-01

    Full Text Available From studies of exotic quantum many-body phenomena to applications in spintronics and quantum information processing, topological materials are poised to revolutionize the condensed-matter frontier and the landscape of modern materials science. Accordingly, there is a broad effort to realize topologically nontrivial electronic and photonic materials for fundamental science as well as practical applications. In this work, we demonstrate the first simultaneous site- and time-resolved measurements of a time-reversal-invariant topological band structure, which we realize in a radio-frequency photonic circuit. We control band-structure topology via local permutation of a traveling-wave capacitor-inductor network, increasing robustness by going beyond the tight-binding limit. We observe a gapped density of states consistent with a modified Hofstadter spectrum at a flux per plaquette of ϕ=π/2. In situ probes of the band gaps reveal spatially localized bulk states and delocalized edge states. Time-resolved measurements reveal dynamical separation of localized edge excitations into spin-polarized currents. The radio-frequency circuit paradigm is naturally compatible with nonlocal coupling schemes, allowing us to implement a Möbius strip topology inaccessible in conventional systems. This room-temperature experiment illuminates the origins of topology in band structure, and when combined with circuit quantum electrodynamics techniques, it provides a direct path to topologically ordered quantum matter.

  6. Time- and Site-Resolved Dynamics in a Topological Circuit

    Science.gov (United States)

    Ningyuan, Jia; Owens, Clai; Sommer, Ariel; Schuster, David; Simon, Jonathan

    2015-04-01

    From studies of exotic quantum many-body phenomena to applications in spintronics and quantum information processing, topological materials are poised to revolutionize the condensed-matter frontier and the landscape of modern materials science. Accordingly, there is a broad effort to realize topologically nontrivial electronic and photonic materials for fundamental science as well as practical applications. In this work, we demonstrate the first simultaneous site- and time-resolved measurements of a time-reversal-invariant topological band structure, which we realize in a radio-frequency photonic circuit. We control band-structure topology via local permutation of a traveling-wave capacitor-inductor network, increasing robustness by going beyond the tight-binding limit. We observe a gapped density of states consistent with a modified Hofstadter spectrum at a flux per plaquette of ϕ =π /2 . In situ probes of the band gaps reveal spatially localized bulk states and delocalized edge states. Time-resolved measurements reveal dynamical separation of localized edge excitations into spin-polarized currents. The radio-frequency circuit paradigm is naturally compatible with nonlocal coupling schemes, allowing us to implement a Möbius strip topology inaccessible in conventional systems. This room-temperature experiment illuminates the origins of topology in band structure, and when combined with circuit quantum electrodynamics techniques, it provides a direct path to topologically ordered quantum matter.

  7. Variants of Topology Editing Strategy in the Subsystem of Printed Circuit Boards Manufacturability Improvement

    OpenAIRE

    Roman Panchak; Konstantyn Kolesnyk; Marian Lobur

    2011-01-01

    This paper focuses on the variants of printed circuit boards topology editing strategies implemented in the subsystem of automatic printed circuit boards topology editing. Depending on the requirements for printed circuit board topology, a subsystem user can create variants of editing strategies in order to minimize the amount of the technologically justified places with a minimum clearance between the elements of the topology.

  8. Observation of topological transitions in interacting quantum circuits.

    Science.gov (United States)

    Roushan, P; Neill, C; Chen, Yu; Kolodrubetz, M; Quintana, C; Leung, N; Fang, M; Barends, R; Campbell, B; Chen, Z; Chiaro, B; Dunsworth, A; Jeffrey, E; Kelly, J; Megrant, A; Mutus, J; O'Malley, P J J; Sank, D; Vainsencher, A; Wenner, J; White, T; Polkovnikov, A; Cleland, A N; Martinis, J M

    2014-11-13

    Topology, with its abstract mathematical constructs, often manifests itself in physics and has a pivotal role in our understanding of natural phenomena. Notably, the discovery of topological phases in condensed-matter systems has changed the modern conception of phases of matter. The global nature of topological ordering, however, makes direct experimental probing an outstanding challenge. Present experimental tools are mainly indirect and, as a result, are inadequate for studying the topology of physical systems at a fundamental level. Here we employ the exquisite control afforded by state-of-the-art superconducting quantum circuits to investigate topological properties of various quantum systems. The essence of our approach is to infer geometric curvature by measuring the deflection of quantum trajectories in the curved space of the Hamiltonian. Topological properties are then revealed by integrating the curvature over closed surfaces, a quantum analogue of the Gauss-Bonnet theorem. We benchmark our technique by investigating basic topological concepts of the historically important Haldane model after mapping the momentum space of this condensed-matter model to the parameter space of a single-qubit Hamiltonian. In addition to constructing the topological phase diagram, we are able to visualize the microscopic spin texture of the associated states and their evolution across a topological phase transition. Going beyond non-interacting systems, we demonstrate the power of our method by studying topology in an interacting quantum system. This required a new qubit architecture that allows for simultaneous control over every term in a two-qubit Hamiltonian. By exploring the parameter space of this Hamiltonian, we discover the emergence of an interaction-induced topological phase. Our work establishes a powerful, generalizable experimental platform to study topological phenomena in quantum systems.

  9. Synthesis of Arbitrary Quantum Circuits to Topological Assembly

    Science.gov (United States)

    Paler, Alexandru; Devitt, Simon J.; Fowler, Austin G.

    2016-08-01

    Given a quantum algorithm, it is highly nontrivial to devise an efficient sequence of physical gates implementing the algorithm on real hardware and incorporating topological quantum error correction. In this paper, we present a first step towards this goal, focusing on generating correct and simple arrangements of topological structures that correspond to a given quantum circuit and largely neglecting their efficiency. We detail the many challenges that will need to be tackled in the pursuit of efficiency. The software source code can be consulted at https://github.com/alexandrupaler/tqec.

  10. Circuit topology of self-interacting chains: implications for folding and unfolding dynamics.

    Science.gov (United States)

    Mugler, Andrew; Tans, Sander J; Mashaghi, Alireza

    2014-11-07

    Understanding the relationship between molecular structure and folding is a central problem in disciplines ranging from biology to polymer physics and DNA origami. Topology can be a powerful tool to address this question. For a folded linear chain, the arrangement of intra-chain contacts is a topological property because rearranging the contacts requires discontinuous deformations. Conversely, the topology is preserved when continuously stretching the chain while maintaining the contact arrangement. Here we investigate how the folding and unfolding of linear chains with binary contacts is guided by the topology of contact arrangements. We formalize the topology by describing the relations between any two contacts in the structure, which for a linear chain can either be in parallel, in series, or crossing each other. We show that even when other determinants of folding rate such as contact order and size are kept constant, this 'circuit' topology determines folding kinetics. In particular, we find that the folding rate increases with the fractions of parallel and crossed relations. Moreover, we show how circuit topology constrains the conformational phase space explored during folding and unfolding: the number of forbidden unfolding transitions is found to increase with the fraction of parallel relations and to decrease with the fraction of series relations. Finally, we find that circuit topology influences whether distinct intermediate states are present, with crossed contacts being the key factor. The approach presented here can be more generally applied to questions on molecular dynamics, evolutionary biology, molecular engineering, and single-molecule biophysics.

  11. Circuit Simulation for Solar Power Maximum Power Point Tracking with Different Buck-Boost Converter Topologies

    OpenAIRE

    2014-01-01

    The power converter is one of the essential elements for effective use of renewable power sources. This paper focuses on the development of a circuit simulation model for maximum power point tracking (MPPT) evaluation of solar power that involves using different buck-boost power converter topologies; including SEPIC, Zeta, and four-switch type buck-boost DC/DC converters. The circuit simulation model mainly includes three subsystems: a PV model; a buck-boost converter-based MPPT system; and ...

  12. Research on current sharing of paralleled IGBTs in different DC breaker circuit topologies

    Directory of Open Access Journals (Sweden)

    Chen Ying

    2016-01-01

    Full Text Available IGBT modules used in series and parallel to satisfy the requirement in high-power DC circuit breakers are often prone to large-current destruction due to current unbalance between paralleled IGBTs. It is of great importance to identify the current unbalance causes and to find a method optimizing the current sharing of paralleled IGBTs. In this paper the current-sharing influencing factors are discussed and verified by simulation. Two possible circuit topologies used in DC circuit breakers are proposed and simulated to see their performance in current sharing. The results show that one of them can provide us with a simple and effective method to achieve good current balancing in the DC circuit breaker application.

  13. Research on a new active power filter topology based on chopper circuit

    CERN Document Server

    Xiaoling, Guo; Bo, Zhang; Jing, Zhang

    2015-01-01

    The active power filter (APF) is attracting more and more attention for its outstanding performance in current and voltage ripple compensation. As modern high-energy accelerators are demanding much more stringent current ripple guideline, the APF is introduced to the magnet power supply (MPS) in accelerator system. However, the conventional APF has a lot of shortages and drawbacks due to its traditional topology, such as complex structure, nonadjustable working voltage, requirement of power supply, and so on. This paper proposes a new topology of APF, which is working as two types of chopper circuits. This APF need not extra electricity, but to use the power of the MPS current ripple to realize ripple depressing. At the end of this paper, the experiment result proves its feasibility and effect.

  14. Efficient physical embedding of topologically complex information processing networks in brains and computer circuits.

    Directory of Open Access Journals (Sweden)

    Danielle S Bassett

    2010-04-01

    Full Text Available Nervous systems are information processing networks that evolved by natural selection, whereas very large scale integrated (VLSI computer circuits have evolved by commercially driven technology development. Here we follow historic intuition that all physical information processing systems will share key organizational properties, such as modularity, that generally confer adaptivity of function. It has long been observed that modular VLSI circuits demonstrate an isometric scaling relationship between the number of processing elements and the number of connections, known as Rent's rule, which is related to the dimensionality of the circuit's interconnect topology and its logical capacity. We show that human brain structural networks, and the nervous system of the nematode C. elegans, also obey Rent's rule, and exhibit some degree of hierarchical modularity. We further show that the estimated Rent exponent of human brain networks, derived from MRI data, can explain the allometric scaling relations between gray and white matter volumes across a wide range of mammalian species, again suggesting that these principles of nervous system design are highly conserved. For each of these fractal modular networks, the dimensionality of the interconnect topology was greater than the 2 or 3 Euclidean dimensions of the space in which it was embedded. This relatively high complexity entailed extra cost in physical wiring: although all networks were economically or cost-efficiently wired they did not strictly minimize wiring costs. Artificial and biological information processing systems both may evolve to optimize a trade-off between physical cost and topological complexity, resulting in the emergence of homologous principles of economical, fractal and modular design across many different kinds of nervous and computational networks.

  15. Quantum resistor-capacitor circuit with Majorana fermion modes in a chiral topological superconductor.

    Science.gov (United States)

    Lee, Minchul; Choi, Mahn-Soo

    2014-08-15

    We investigate the mesoscopic resistor-capacitor circuit consisting of a quantum dot coupled to spatially separated Majorana fermion modes in a chiral topological superconductor. We find substantially enhanced relaxation resistance due to the nature of Majorana fermions, which are their own antiparticles and are composed of particle and hole excitations in the same abundance. Further, if only a single Majorana mode is involved, the zero-frequency relaxation resistance is completely suppressed due to a destructive interference. As a result, the Majorana mode opens an exotic dissipative channel on a superconductor which is typically regarded as dissipationless due to its finite superconducting gap.

  16. Circuit Simulation for Solar Power Maximum Power Point Tracking with Different Buck-Boost Converter Topologies

    Directory of Open Access Journals (Sweden)

    Jaw-Kuen Shiau

    2014-08-01

    Full Text Available The power converter is one of the essential elements for effective use of renewable power sources. This paper focuses on the development of a circuit simulation model for maximum power point tracking (MPPT evaluation of solar power that involves using different buck-boost power converter topologies; including SEPIC, Zeta, and four-switch type buck-boost DC/DC converters. The circuit simulation model mainly includes three subsystems: a PV model; a buck-boost converter-based MPPT system; and a fuzzy logic MPPT controller. Dynamic analyses of the current-fed buck-boost converter systems are conducted and results are presented in the paper. The maximum power point tracking function is achieved through appropriate control of the power switches of the power converter. A fuzzy logic controller is developed to perform the MPPT function for obtaining maximum power from the PV panel. The MATLAB-based Simulink piecewise linear electric circuit simulation tool is used to verify the complete circuit simulation model.

  17. A modified circuit topology for inductive pulsed power supply based on HTSPPTs

    Science.gov (United States)

    Li, Haitao; Zhang, Cunshan; Wang, Teng; Gao, Mingliang; Li, Zhenmei; Zou, Guofeng

    2016-10-01

    High temperature superconducting pulsed power transformer (HTSPPT) provides an efficient method for inductive energy storage and current multiplication. The primary inductor of HTSPPT used for energy storage is made of high temperature superconducting coils, and the secondary inductor used for current pulse generation is made of normal conductor coils. In the initial circuit, the secondary inductor generates current pulse by switching out the coupled primary superconducting inductor. However, during the switching period, the leakage flux caused by imperfect coupling and the sudden change in primary current induce a voltage across the opening switch which exceeds the affordability of modern solid-state switches. In previous studies, a half-cycle oscillatory discharge circuit is proposed to mitigate these problems by using a capacitor to recapture the energy in the leakage flux and to slow down the turnoff of current in the primary. However, there are still some problems should be settled. For example, the output pulse cannot be adjusted, the residual energy cannot be recovered and the capacitor branch circuit may have an impact on the charging process. In the paper, a modified discharge circuit topology is introduced to solve these problems. A multi-module system comprising of several HTSPPTs charging in series connection and discharging in parallel is also designed and simulated. This system can be used to power an electromagnetic emission device.

  18. Dynamic changes in neural circuit topology following mild mechanical injury in vitro.

    Science.gov (United States)

    Patel, Tapan P; Ventre, Scott C; Meaney, David F

    2012-01-01

    Despite its enormous incidence, mild traumatic brain injury is not well understood. One aspect that needs more definition is how the mechanical energy during injury affects neural circuit function. Recent developments in cellular imaging probes provide an opportunity to assess the dynamic state of neural networks with single-cell resolution. In this article, we developed imaging methods to assess the state of dissociated cortical networks exposed to mild injury. We estimated the imaging conditions needed to achieve accurate measures of network properties, and applied these methodologies to evaluate if mild mechanical injury to cortical neurons produces graded changes to either spontaneous network activity or altered network topology. We found that modest injury produced a transient increase in calcium activity that dissipated within 1 h after injury. Alternatively, moderate mechanical injury produced immediate disruption in network synchrony, loss in excitatory tone, and increased modular topology. A calcium-activated neutral protease (calpain) was a key intermediary in these changes; blocking calpain activation restored the network nearly completely to its pre-injury state. Together, these findings show a more complex change in neural circuit behavior than previously reported for mild mechanical injury, and highlight at least one important early mechanism responsible for these changes.

  19. Implementation Considerations, Not Topological Differences, Are the Main Determinants of Noise Suppression Properties in Feedback and Incoherent Feedforward Circuits.

    Science.gov (United States)

    Buzi, Gentian; Khammash, Mustafa

    2016-06-01

    Biological systems use a variety of mechanisms to deal with the uncertain nature of their external and internal environments. Two of the most common motifs employed for this purpose are the incoherent feedforward (IFF) and feedback (FB) topologies. Many theoretical and experimental studies suggest that these circuits play very different roles in providing robustness to uncertainty in the cellular environment. Here, we use a control theoretic approach to analyze two common FB and IFF architectures that make use of an intermediary species to achieve regulation. We show the equivalence of both circuits topologies in suppressing static cell-to-cell variations. While both circuits can suppress variations due to input noise, they are ineffective in suppressing inherent chemical reaction stochasticity. Indeed, these circuits realize comparable improvements limited to a modest 25% variance reduction in best case scenarios. Such limitations are attributed to the use of intermediary species in regulation, and as such, they persist even for circuit architectures that combine both IFF and FB features. Intriguingly, while the FB circuits are better suited in dealing with dynamic input variability, the most significant difference between the two topologies lies not in the structural features of the circuits, but in their practical implementation considerations.

  20. Four-dimensional address topology for circuits with stacked multilayer crossbar arrays.

    Science.gov (United States)

    Strukov, Dmitri B; Williams, R Stanley

    2009-12-01

    We present a topological framework that provides a simple yet powerful electronic circuit architecture for constructing and using multilayer crossbar arrays, allowing a significantly increased integration density of memristive crosspoint devices beyond the scaling limits of lateral feature sizes. The truly remarkable feature of such circuits, which is an extension of the CMOL (Cmos + MOLecular-scale devices) concept for an area-like interface to a three-dimensional system, is that a large-feature-size complimentary metal-oxide-semiconductor (CMOS) substrate can provide high-density interconnects to multiple crossbar layers through a single set of vertical vias. The physical locations of the memristive devices are mapped to a four-dimensional logical address space such that unique access from the CMOS substrate is provided to every device in a stacked array of crossbars. This hybrid architecture is compatible with digital memories, field-programmable gate arrays, and biologically inspired adaptive networks and with state-of-the-art integrated circuit foundries.

  1. A novel circuit topology of modified switched boost hybrid resonant inverter fitted induction heating equipment

    Directory of Open Access Journals (Sweden)

    Bhattacharya Ananyo

    2016-12-01

    Full Text Available A novel circuit topology of modified switched boost high frequency hybrid resonant inverter fitted induction heating equipment is presented in this paper for efficient induction heating. Recently, induction heating technique is becoming very popular for both domestic and industrial purposes because of its high energy efficiency and controllability. Generally in induction heating, a high frequency alternating magnetic field is required to induce the eddy currents in the work piece. High frequency resonant inverters are incorporated in induction heating equipment which produce a high frequency alternating magnetic field surrounding the coil. Previously this high frequency alternating magnetic field was produced by voltage source inverters. But VSIs have several demerits. So, in this paper, a new scheme of modified switched boost high frequency hybrid resonant inverter fitted induction heating equipment has been depicted which enhances the energy efficiency and controllability and the same is validated by PSIM.

  2. Architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks

    Directory of Open Access Journals (Sweden)

    Nielsen Jens

    2008-02-01

    Full Text Available Abstract Background Uncovering the operating principles underlying cellular processes by using 'omics' data is often a difficult task due to the high-dimensionality of the solution space that spans all interactions among the bio-molecules under consideration. A rational way to overcome this problem is to use the topology of bio-molecular interaction networks in order to constrain the solution space. Such approaches systematically integrate the existing biological knowledge with the 'omics' data. Results Here we introduce a hypothesis-driven method that integrates bio-molecular network topology with transcriptome data, thereby allowing the identification of key biological features (Reporter Features around which transcriptional changes are significantly concentrated. We have combined transcriptome data with different biological networks in order to identify Reporter Gene Ontologies, Reporter Transcription Factors, Reporter Proteins and Reporter Complexes, and use this to decipher the logic of regulatory circuits playing a key role in yeast glucose repression and human diabetes. Conclusion Reporter Features offer the opportunity to identify regulatory hot-spots in bio-molecular interaction networks that are significantly affected between or across conditions. Results of the Reporter Feature analysis not only provide a snapshot of the transcriptional regulatory program but also are biologically easy to interpret and provide a powerful way to generate new hypotheses. Our Reporter Features analyses of yeast glucose repression and human diabetes data brings hints towards the understanding of the principles of transcriptional regulation controlling these two important and potentially closely related systems.

  3. Engineered neuronal circuits: A new platform for studying the roleof modular topology

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    Mark eShein-Idelson

    2011-09-01

    Full Text Available Neuron-glia cultures serve as a valuable model system for exploring the bio-molecular activity of single cells. Since neurons in culture can be conveniently recorded with great fidelity from many sites simultaneously, it has long been suggested that uniform cultured neurons may also be used to investigate network-level mechanisms pertinent to information processing, activity propagation, memory and learning. But how much of the functionality of neural circuits can be retained in-vitro remains an open question. Recent studies utilizing patterned networks suggest that they provide a most useful platform to address fundamental questions in neuroscience. Here we review recent efforts in the realm of patterned networks' activity investigations. We give a brief overview of the patterning methods and experimental approaches commonly employed in the field, and summarize the main results reported in the literature. The general picture that emerges from these reports indicates that patterned networks with uniform connectivity do not exhibit unique activity patterns. Rather, their activity is very similar to that of unpatterned uniform networks. However, by breaking the connectivity homogeneity, using a modular architecture, it is possible to introduce pronounced topology-related gating and delay effects. These findings suggest that patterned cultured networks may serve as a new platform for studying the role of modularity in neuronal circuits.

  4. Topology

    CERN Document Server

    Lefschetz, Solomon

    1930-01-01

    Lefschetz's Topology was written in the period in between the beginning of topology, by Poincaré, and the establishment of algebraic topology as a well-formed subject, separate from point-set or geometric topology. At this time, Lefschetz had already proved his first fixed-point theorems. In some sense, the present book is a description of the broad subject of topology into which Lefschetz's theory of fixed points fits. Lefschetz takes the opportunity to describe some of the important applications of his theory, particularly in algebraic geometry, to problems such as counting intersections of

  5. Topology

    CERN Document Server

    Hocking, John G

    1988-01-01

    ""As textbook and reference work, this is a valuable addition to the topological literature."" - Mathematical ReviewsDesigned as a text for a one-year first course in topology, this authoritative volume offers an excellent general treatment of the main ideas of topology. It includes a large number and variety of topics from classical topology as well as newer areas of research activity.There are four set-theoretic chapters, followed by four primarily algebraic chapters. Chapter I covers the fundamentals of topological and metrical spaces, mappings, compactness, product spaces, the Tychonoff t

  6. Comparative Analyses of Phase Noise in 28 nm CMOS LC Oscillator Circuit Topologies: Hartley, Colpitts, and Common-Source Cross-Coupled Differential Pair

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    Ilias Chlis

    2014-01-01

    Full Text Available This paper reports comparative analyses of phase noise in Hartley, Colpitts, and common-source cross-coupled differential pair LC oscillator topologies in 28 nm CMOS technology. The impulse sensitivity function is used to carry out both qualitative and quantitative analyses of the phase noise exhibited by each circuit component in each circuit topology with oscillation frequency ranging from 1 to 100 GHz. The comparative analyses show the existence of four distinct frequency regions in which the three oscillator topologies rank unevenly in terms of best phase noise performance, due to the combined effects of device noise and circuit node sensitivity.

  7. Comparative analyses of phase noise in 28 nm CMOS LC oscillator circuit topologies: Hartley, Colpitts, and common-source cross-coupled differential pair.

    Science.gov (United States)

    Chlis, Ilias; Pepe, Domenico; Zito, Domenico

    2014-01-01

    This paper reports comparative analyses of phase noise in Hartley, Colpitts, and common-source cross-coupled differential pair LC oscillator topologies in 28 nm CMOS technology. The impulse sensitivity function is used to carry out both qualitative and quantitative analyses of the phase noise exhibited by each circuit component in each circuit topology with oscillation frequency ranging from 1 to 100 GHz. The comparative analyses show the existence of four distinct frequency regions in which the three oscillator topologies rank unevenly in terms of best phase noise performance, due to the combined effects of device noise and circuit node sensitivity.

  8. Topology

    CERN Document Server

    Kuratowski, Kazimierz

    1966-01-01

    Topology, Volume I deals with topology and covers topics ranging from operations in logic and set theory to Cartesian products, mappings, and orderings. Cardinal and ordinal numbers are also discussed, along with topological, metric, and complete spaces. Great use is made of closure algebra. Comprised of three chapters, this volume begins with a discussion on general topological spaces as well as their specialized aspects, including regular, completely regular, and normal spaces. Fundamental notions such as base, subbase, cover, and continuous mapping, are considered, together with operations

  9. Topology

    CERN Document Server

    Kuratowski, Kazimierz

    1968-01-01

    Topology, Volume II deals with topology and covers topics ranging from compact spaces and connected spaces to locally connected spaces, retracts, and neighborhood retracts. Group theory and some cutting problems are also discussed, along with the topology of the plane. Comprised of seven chapters, this volume begins with a discussion on the compactness of a topological space, paying particular attention to Borel, Lebesgue, Riesz, Cantor, and Bolzano-Weierstrass conditions. Semi-continuity and topics in dimension theory are also considered. The reader is then introduced to the connecte

  10. Topology

    CERN Document Server

    Manetti, Marco

    2015-01-01

    This is an introductory textbook on general and algebraic topology, aimed at anyone with a basic knowledge of calculus and linear algebra. It provides full proofs and includes many examples and exercises. The covered topics include: set theory and cardinal arithmetic; axiom of choice and Zorn's lemma; topological spaces and continuous functions; connectedness and compactness; Alexandrov compactification; quotient topologies; countability and separation axioms; prebasis and Alexander's theorem; the Tychonoff theorem and paracompactness; complete metric spaces and function spaces; Baire spaces; homotopy of maps; the fundamental group; the van Kampen theorem; covering spaces; Brouwer and Borsuk's theorems; free groups and free product of groups; and basic category theory. While it is very concrete at the beginning, abstract concepts are gradually introduced. It is suitable for anyone needing a basic, comprehensive introduction to general and algebraic topology and its applications.

  11. Application of the model of the printed circuit board with regard to the topology of external conductive layers for calculation of the thermal conditions of the printed circuit board

    Science.gov (United States)

    Rybakov, I. M.; Goryachev, N. V.; Kochegarov, I. I.; Grishko, A. K.; Brostilov, S. A.; Yurkov, N. K.

    2017-01-01

    The paper proves the necessity of taking into account external conductive layers of the printed circuit board with the thermal physical designing radio-electronic means. For example, a single printed circuit board shows the level of influence of the external conductive layer on the thermal conditions of the printed circuit board. It proved the influence of Joule heat in the thermal conditions of a single conductor. Developed geometrical and thermal printed circuit board models take into account the topological layer and can improve the accuracy of determining the thermal conditions of the printed circuit board.

  12. Premotor Diagnosis of Parkinson's Disease.

    Science.gov (United States)

    Reichmann, Heinz

    2017-08-03

    Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such as hyposmia, constipation, REM sleep behavior disorder and depression may antecede these motor symptoms for years. It would be ideal, if we had a biomarker which would allow to predict who with one or two of these pre-motor symptoms will develop the movement disorder Parkinson's disease (PD). Thus, it is interesting to learn that biopsies of the submandibular gland or colon biopsies may be a means to predict PD, if there is a high amout of abnormally folded alpha-synuclein and phosphorylated alpha-synuclein. This would be of relevance if we would have available means to stop the propagation of abnormal alpha-synuclein which is otherwise one of the reasons of this spreading disease PD.

  13. Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

    Directory of Open Access Journals (Sweden)

    Sándor Pongor

    2012-04-01

    Full Text Available Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL gene regulation mechanism called quorum sensing (QS. The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.

  14. New Squarer Circuits and a Current-Mode Full-Wave Rectifier Topology Suitable for Integration

    Directory of Open Access Journals (Sweden)

    S. Minaei

    2010-12-01

    Full Text Available In this paper, three squarer configurations and a current-mode (CM full-wave rectifier circuit are suggested. The first and second squarer configurations respectively use two PMOS and two NMOS transistors while the third one employs three PMOS and one NMOS transistors. A CM full-wave rectifier with high output impedance current is developed. All of the proposed circuits provide several advantages such as low number of components and less power consumption. The proposed circuits are simulated using SPICE program to demonstrate their performance and workability.

  15. An Approximate Analytical (Structural Superposition in Terms of Two, or More, α- Circuits of the Same Topology: Pt.1 – Description of the Superposition

    Directory of Open Access Journals (Sweden)

    E. Gluskin

    2013-09-01

    Full Text Available One-ports named “f-circuits”, composed of similar conductors described by a monotonic polynomial, or quasi-polynomial (i.e. with positive but not necessarily integer, powers characteristic i = f(v are studied, focusing on the algebraic map f → F. Here F(. is the input conductivity characteristic; i.e., iin = F(vin is the input current. The “power-law” “a-circuit” introduced in [1], for which f(v ~ v a , is an important particular case. By means of a generalization of a parallel connection, the f-circuits are constructed from the a-circuits of the same topology, with different a, so that the given topology is kept, and ‘f’ is an additive function of the connection. We observe and consider an associated, generally approximated, but, in all of the cases studied, always high-precision, specific superposition. This superposition is in terms of f → F, and it means that F(. of the connection is close to the sum of the input currents of the independent a-circuits, all connected in parallel to the same source. In other words, F(. is well approximated by a linear combination of the same degrees of the independent variable as in f(., i.e. the map of the characteristics f → F is close to a linear one. This unexpected result is useful for understanding nonlinear algebraic circuits, and is missed in the classical theory. The cases of f(v = D1v + D2v 2 and f(v = D1v + D3v 3, are analyzed in examples. Special topologies when the superposition must be ideal, are also considered. In the second part [2] of the work the “circuit mechanism” that is responsible for the high precision of the superposition, in the most general case, is explained.

  16. A hybrid pulse combining topology utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer.

    Science.gov (United States)

    Li, Jiangtao; Zhao, Zheng; Sun, Yi; Liu, Yuhao; Ren, Ziyuan; He, Jiaxin; Cao, Hui; Zheng, Minjun

    2017-03-01

    Numerous applications driven by pulsed voltage require pulses to be with high amplitude, high repetitive frequency, and narrow width, which could be satisfied by utilizing avalanche transistors. The output improvement is severely limited by power capacities of transistors. Pulse combining is an effective approach to increase the output amplitude while still adopting conventional pulse generating modules. However, there are drawbacks in traditional topologies including the saturation tendency of combining efficiency and waveform oscillation. In this paper, a hybrid pulse combining topology was adopted utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer. The factors affecting the combining efficiency were determined including the output time synchronization of Marx circuits, and the quantity and position of magnetic cores. The numbers of the parallel modules and the stages were determined by the output characteristics of each combining method. Experimental results illustrated the ability of generating pulses with 2-14 kV amplitude, 7-11 ns width, and a maximum 10 kHz repetitive rate on a matched 50-300 Ω resistive load. The hybrid topology would be a convinced pulse combining method for similar nanosecond pulse generators based on the solid-state switches.

  17. A hybrid pulse combining topology utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer

    Science.gov (United States)

    Li, Jiangtao; Zhao, Zheng; Sun, Yi; Liu, Yuhao; Ren, Ziyuan; He, Jiaxin; Cao, Hui; Zheng, Minjun

    2017-03-01

    Numerous applications driven by pulsed voltage require pulses to be with high amplitude, high repetitive frequency, and narrow width, which could be satisfied by utilizing avalanche transistors. The output improvement is severely limited by power capacities of transistors. Pulse combining is an effective approach to increase the output amplitude while still adopting conventional pulse generating modules. However, there are drawbacks in traditional topologies including the saturation tendency of combining efficiency and waveform oscillation. In this paper, a hybrid pulse combining topology was adopted utilizing the combination of modularized avalanche transistor Marx circuits, direct pulse adding, and transmission line transformer. The factors affecting the combining efficiency were determined including the output time synchronization of Marx circuits, and the quantity and position of magnetic cores. The numbers of the parallel modules and the stages were determined by the output characteristics of each combining method. Experimental results illustrated the ability of generating pulses with 2-14 kV amplitude, 7-11 ns width, and a maximum 10 kHz repetitive rate on a matched 50-300 Ω resistive load. The hybrid topology would be a convinced pulse combining method for similar nanosecond pulse generators based on the solid-state switches.

  18. Design and Analysis of Broad-Band Fixed-Tuned Submillimeter-Waveguide Multipliers using MMIC Style Circuit Topology

    Science.gov (United States)

    Bruston, J.; Kim, M.; Martin, S. C.; Mehdi, I.; Smith, R. P.; Siegel, P. H.

    1996-01-01

    The design and analysis of varactor diode doubler, quadrupler and cascaded doubler circuits for 320 and 640 GHz have been completed. A new approach has been employed to produce a tunerless waveguide mount with a very flexible, frequency scaleable, MMIC style multiplier circuit. The concept, design, predicted performance and measurements on some of the constituent mount elements are presented.

  19. Topological self-organization and prediction learning support both action and lexical chains in the brain.

    Science.gov (United States)

    Chersi, Fabian; Ferro, Marcello; Pezzulo, Giovanni; Pirrelli, Vito

    2014-07-01

    A growing body of evidence in cognitive psychology and neuroscience suggests a deep interconnection between sensory-motor and language systems in the brain. Based on recent neurophysiological findings on the anatomo-functional organization of the fronto-parietal network, we present a computational model showing that language processing may have reused or co-developed organizing principles, functionality, and learning mechanisms typical of premotor circuit. The proposed model combines principles of Hebbian topological self-organization and prediction learning. Trained on sequences of either motor or linguistic units, the network develops independent neuronal chains, formed by dedicated nodes encoding only context-specific stimuli. Moreover, neurons responding to the same stimulus or class of stimuli tend to cluster together to form topologically connected areas similar to those observed in the brain cortex. Simulations support a unitary explanatory framework reconciling neurophysiological motor data with established behavioral evidence on lexical acquisition, access, and recall. Copyright © 2014 Cognitive Science Society, Inc.

  20. Can we image premotor Parkinson disease?

    Science.gov (United States)

    Marek, Kenneth; Jennings, Danna

    2009-02-17

    Pathology and imaging studies have shown that patients with Parkinson disease (PD) have a prolonged period of uncertain duration when vulnerable neuronal populations are degenerating, but typical motor symptoms have not yet developed. This provides both an opportunity-it may be best to test new medications and, ultimately, treat PD patients during this early phase of disease--and a challenge--how to find these premotor PD subjects? Imaging biomarkers targeting the premotor period are critical to elucidate both the onset and progression of premotor PD. Widespread data have demonstrated that dopaminergic imaging can detect PD subjects at the motor symptom threshold. Novel strategies combining dopaminergic imaging with known genetic mutations for PD or early clinical signs and PD-associated symptoms, such as olfactory loss and sleep disturbances like REM behavior disorder, have begun to be used to identify individuals at risk for PD before motor symptoms become manifest. Early studies also have used imaging targeting norepinephrine, serotonin, cholinergic, or other neuronal systems to focus on early cardiac, cognitive, and behavioral symptoms. Imaging of nondopaminergic targets such as inflammation or alpha-synuclein deposition may provide further insight into the etiology of PD. Given the multiple genetic etiologies for PD already identified, the marked variability in the loss of dopaminergic markers measured by imaging at motor symptom onset, and the clear heterogeneity of clinical symptoms at PD onset, it is certain that many imaging biomarkers with a focus ranging from clinical symptoms to PD pathobiology to molecular genetic mechanisms, will be necessary to fully map PD risk.

  1. Long-range neural activity evoked by premotor cortex stimulation: a TMS/EEG co-registration study

    Directory of Open Access Journals (Sweden)

    Marco eZanon

    2013-11-01

    Full Text Available The premotor cortex is one of the fundamental structures composing the neural networks of the human brain. It is implicated in many behaviors and cognitive tasks, ranging from movement to attention and eye-related activity. Therefore, neural circuits that are related to premotor cortex have been studied to clarify their connectivity and/or role in different tasks. In the present work, we aimed to investigate the propagation of the neural activity evoked in the dorsal premotor cortex using transcranial magnetic stimulation/electroencephalography (TMS/EEG. Towards this end, interest was focused on the neural dynamics elicited in long-ranging temporal and spatial networks. Twelve healthy volunteers underwent a single-pulse TMS protocol in a resting condition with eyes closed, and the evoked activity, measured by EEG, was compared to a sham condition in a time window ranging from 45 msec to about 200 msec after TMS. Spatial and temporal investigations were carried out with sLORETA. TMS was found to induce propagation of neural activity mainly in the contralateral sensorimotor and frontal cortices, at about 130 msec after delivery of the stimulus. Different types of analyses showed propagated activity also in posterior, mainly visual, regions, in a time window between 70 and 130 msec. Finally, a likely rebounding activation of the sensorimotor and frontal regions, was observed in various time ranges. Taken together, the present findings further characterize the neural circuits that are driven by dorsal premotor cortex activation in healthy humans.

  2. Differential activation of the lateral premotor cortex during action observation

    Directory of Open Access Journals (Sweden)

    Stark Rudolf

    2010-07-01

    Full Text Available Abstract Background Action observation leads to neural activation of the human premotor cortex. This study examined how the level of motor expertise (expert vs. novice in ballroom dancing and the visual viewpoint (internal vs. external viewpoint influence this activation within different parts of this area of the brain. Results Sixteen dance experts and 16 novices observed ballroom dance videos from internal or external viewpoints while lying in a functional magnetic resonance imaging scanner. A conjunction analysis of all observation conditions showed that action observation activated distinct networks of premotor, parietal, and cerebellar structures. Experts revealed increased activation in the ventral premotor cortex compared to novices. An internal viewpoint led to higher activation of the dorsal premotor cortex. Conclusions The present results suggest that the ventral and dorsal premotor cortex adopt differential roles during action observation depending on the level of motor expertise and the viewpoint.

  3. Neuroimaging in pre-motor Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Thomas R. Barber

    2017-01-01

    Full Text Available The process of neurodegeneration in Parkinson's disease begins long before the onset of clinical motor symptoms, resulting in substantial cell loss by the time a diagnosis can be made. The period between the onset of neurodegeneration and the development of motoric disease would be the ideal time to intervene with disease modifying therapies. This pre-motor phase can last many years, but the lack of a specific clinical phenotype means that objective biomarkers are needed to reliably detect prodromal disease. In recent years, recognition that patients with REM sleep behaviour disorder (RBD are at particularly high risk of future parkinsonism has enabled the development of large prodromal cohorts in which to investigate novel biomarkers, and neuroimaging has generated some of the most promising results to date. Here we review investigations undertaken in RBD and other pre-clinical cohorts, including modalities that are well established in clinical Parkinson's as well as novel imaging methods. Techniques such as high resolution MRI of the substantia nigra and functional imaging of Parkinsonian brain networks have great potential to facilitate early diagnosis. Further longitudinal studies will establish their true value in quantifying prodromal neurodegeneration and predicting future Parkinson's.

  4. Technologies for converter topologies

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Yan; Zhang, Haiyu

    2017-02-28

    In some embodiments of the disclosed inverter topologies, an inverter may include a full bridge LLC resonant converter, a first boost converter, and a second boost converter. In such embodiments, the first and second boost converters operate in an interleaved manner. In other disclosed embodiments, the inverter may include a half-bridge inverter circuit, a resonant circuit, a capacitor divider circuit, and a transformer.

  5. Reduced parietal connectivity with a premotor writing area in writer's cramp.

    Science.gov (United States)

    Delnooz, Cathérine C S; Helmich, Rick C; Toni, Ivan; van de Warrenburg, Bart P C

    2012-09-15

    Writer's cramp is a task-specific form of dystonia with symptoms characterized by abnormal movements and postures of the hand and arm evident only during writing. Its pathophysiology has been related to faulty sensorimotor integration, abnormal sensory processing, and impaired motor planning. Its symptoms might appear when the computational load of writing pushes a tonically altered circuit outside its operational range. Using resting-state fMRI, we tested whether writer's cramp patients have altered intrinsic functional connectivity in the premotor-parietal circuit. Sixteen patients with right-sided writer's cramp and 19 control subjects were studied. We show that writer's cramp patients have reduced connectivity between the superior parietal lobule and a dorsal precentral region that controls writing movements. This difference between patients and controls occurred in the absence of writing and only in the hemisphere contralateral to the affected hand. This finding adds a novel element to the pathophysiological substrate for writer's cramp, namely, task-independent alterations within a writing-related circuit.

  6. Topology zero: advancing theory and experimentation for power electronics education

    OpenAIRE

    Luchino, Federico

    2012-01-01

    For decades, power electronics education has been based on the fundamentals of three basic topologies: buck, boost, and buck-boost. This thesis presents the analytical framework for the Topology Zero, a general circuit topology that integrates the basic topologies and provides significant insight into the behaviour of converters. As demonstrated, many topologies are just particular cases of the Topology Zero, an important contribution towards the understanding, integration, and conceptualizat...

  7. The human premotor cortex is 'mirror' only for biological actions.

    Science.gov (United States)

    Tai, Yen F; Scherfler, Christoph; Brooks, David J; Sawamoto, Nobukatsu; Castiello, Umberto

    2004-01-20

    Previous work has shown that both human adults and children attend to grasping actions performed by another person but not necessarily to those made by a mechanical device. According to recent neurophysiological data, the monkey premotor cortex contains "mirror" neurons that discharge both when the monkey performs specific manual grasping actions and when it observes another individual performing the same or similar actions. However, when a human model uses tools to perform grasping actions, the mirror neurons are not activated. A similar "mirror" system has been described in humans, but whether or not it is also tuned specifically to biological actions has never been tested. Here we show that when subjects observed manual grasping actions performed by a human model a significant neural response was elicited in the left premotor cortex. This activation was not evident for the observation of grasping actions performed by a robot model commanded by an experimenter. This result indicates for the first time that in humans the mirror system is biologically tuned. This system appears to be the neural substrate for biological preference during action coding.

  8. Dissociable mechanisms of cognitive control in prefrontal and premotor cortex.

    Science.gov (United States)

    Chambers, Christopher D; Bellgrove, Mark A; Gould, Ian C; English, Therese; Garavan, Hugh; McNaught, Elizabeth; Kamke, Marc; Mattingley, Jason B

    2007-12-01

    Intelligent behavior depends on the ability to suppress inappropriate actions and resolve interference between competing responses. Recent clinical and neuroimaging evidence has demonstrated the involvement of prefrontal, parietal, and premotor areas during behaviors that emphasize conflict and inhibition. It remains unclear, however, whether discrete subregions within this network are crucial for overseeing more specific inhibitory demands. Here we probed the functional specialization of human prefrontal cortex by combining repetitive transcranial magnetic stimulation (rTMS) with integrated behavioral measures of response inhibition (stop-signal task) and response competition (flanker task). Participants undertook a combined stop-signal/flanker task after rTMS of the inferior frontal gyrus (IFG) or dorsal premotor cortex (dPM) in each hemisphere. Stimulation of the right IFG impaired stop-signal inhibition under conditions of heightened response competition but did not influence the ability to suppress a competing response. In contrast, stimulation of the right dPM facilitated execution but had no effect on inhibition. Neither of these results was observed during rTMS of corresponding left-hemisphere regions. Overall, our findings are consistent with existing evidence that the right IFG is crucial for inhibitory control. The observed double dissociation of neurodisruptive effects between the right IFG and right dPM further implies that response inhibition and execution rely on distinct neural processes despite activating a common cortical network.

  9. The Dynamical Topological Models of Lagrange’s and Hamiltonian Equations for Complex Nonlinear Electrical Circuit System%复杂非线性电路系统的动力学方程模型

    Institute of Scientific and Technical Information of China (English)

    欧松

    2012-01-01

    Lagrange和Hamilton运动方程是分析力学的基本原理之一和方法论.应用Lagrange和Hamilton原理建立复杂非线性电路保守动力学方程模型是一种形式化可行的方法.对非保守的动力学系统,定义描述电路系统的荷控支路和链控支路的微观结构概念,应用Hamilton结构的方法,可以得到与Lagrange结构等价的方程组;考虑大规模电路系统的复杂性,依据电路系统荷控支路和链控支路微观结构的概念,给出具有控制参量的Lagrange和Hamilton函数,以及具有相应关联矩阵和联接矩阵形式的Lagrange和Hamilton的动态方程;分析了保守和非保守复杂系统拓扑结构关系的描述和其动力学系统的建模,其建模过程具有规范性和方程具有对称性.虽然数学推导过程繁琐,但适合于计算机辅助形式化分析;基于Hamilton方法建立的电路模型为一阶微分动态方程组,特别适合进行理论分析和数值仿真计算.%The Lagrange's and Hamiltonian movement equation are one of the basic principles of analytical mechanics and methodology. The application of Lagrange's and Hamiltonian theory approach to modeling complex nonlinear conservation electrical circuits dynamics system is a practicable in formulation methodology. But for the non conservation electrical circuits dynamics system, a new micro structure conception of electric charge quantitative control branch and magnetic chain control branch in electrical circuit system has been put forward that have equality with the Lagrange's equations; Consideration of the topological complexity of large electrical circuit system, based on the micro structure conception of electric charge quantitative control branch and magnetic chain control branch in electrical circuit, and the Lagrange's and Hamiltonian function that have control parameters are given. ; as well as the Lagrange's and Hamiltonian equations that have incidence matrix and linked matrix; So the

  10. Functional differentiation of the premotor cortex : Behavioural and brain imaging studies in humans

    NARCIS (Netherlands)

    Potgieser, Adriaan Remco Ewoud

    2015-01-01

    The premotor cortex is a brain structure that is involved in the preparation of movements. It has an important role in the final integration of task-related information and to funnel this to the primary motor cortex, which subsequently causes the execution of a movement. Premotor areas can also infl

  11. Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation.

    NARCIS (Netherlands)

    Munchau, A.; Bloem, B.R.; Irlbacher, K.; Trimble, M.R.; Rothwell, J.C.

    2002-01-01

    Connections between the premotor cortex and the primary motor cortex are dense and are important in the visual guidance of arm movements. We have shown previously that it is possible to engage these connections in humans and to measure the net amount of inhibition/facilitation from premotor to motor

  12. Topological code Autotune

    CERN Document Server

    Fowler, Austin G; McInnes, Angus L; Rabbani, Alimohammad

    2012-01-01

    Tailoring a fault-tolerant quantum error correction scheme to a specific physical architecture can be a laborious task. We describe a tool Autotune capable of analyzing and optimizing the classical processing for an arbitrary 2-D qubit architecture making use of arbitrary circuits implementing either the surface code or progressively generated slices of a 3-D topological cluster state with arbitrary stochastic error models for each quantum gate. Autotune is designed to facilitate precise study of the performance of real hardware running topological quantum error correction.

  13. A Parallel Genetic Algorithm for Automated Electronic Circuit Design

    Science.gov (United States)

    Lohn, Jason D.; Colombano, Silvano P.; Haith, Gary L.; Stassinopoulos, Dimitris; Norvig, Peter (Technical Monitor)

    2000-01-01

    We describe a parallel genetic algorithm (GA) that automatically generates circuit designs using evolutionary search. A circuit-construction programming language is introduced and we show how evolution can generate practical analog circuit designs. Our system allows circuit size (number of devices), circuit topology, and device values to be evolved. We present experimental results as applied to analog filter and amplifier design tasks.

  14. Premotor biomarkers for Parkinson's disease - a promising direction of research

    Directory of Open Access Journals (Sweden)

    Haas Brian R

    2012-05-01

    Full Text Available Abstract The second most serious neurodegenerative disease is Parkinson’s disease (PD. Over the past several decades, a strong body of evidence suggests that PD can begin years before the hallmark clinical motor symptoms appear. Biomarkers for PD are urgently needed to differentiate between neurodegenerative disorders, screen novel therapeutics, and predict eventual clinical PD before the onset of symptoms. Some clinical evaluations and neuroimaging techniques have been developed in the last several years with some success in this area. Moreover, other strategies have been utilized to identify biochemical and genetic markers associated with PD leading to the examination of PD progression and pathogenesis in cerebrospinal fluid, blood, or saliva. Finally, interesting results are surfacing from preliminary studies using known PD-associated genetic mutations to assess potential premotor PD biomarkers. The current review highlights recent advances and underscores areas of potential advancement.

  15. Neurons controlling voluntary vocalization in the macaque ventral premotor cortex.

    Directory of Open Access Journals (Sweden)

    Gino Coudé

    Full Text Available The voluntary control of phonation is a crucial achievement in the evolution of speech. In humans, ventral premotor cortex (PMv and Broca's area are known to be involved in voluntary phonation. In contrast, no neurophysiological data are available about the role of the oro-facial sector of nonhuman primates PMv in this function. In order to address this issue, we recorded PMv neurons from two monkeys trained to emit coo-calls. Results showed that a population of motor neurons specifically fire during vocalization. About two thirds of them discharged before sound onset, while the remaining were time-locked with it. The response of vocalization-selective neurons was present only during conditioned (voluntary but not spontaneous (emotional sound emission. These data suggest that the control of vocal production exerted by PMv neurons constitutes a newly emerging property in the monkey lineage, shedding light on the evolution of phonation-based communication from a nonhuman primate species.

  16. Neural encoding of auditory discrimination in ventral premotor cortex

    Science.gov (United States)

    Lemus, Luis; Hernández, Adrián; Romo, Ranulfo

    2009-01-01

    Monkeys have the capacity to accurately discriminate the difference between two acoustic flutter stimuli. In this task, monkeys must compare information about the second stimulus to the memory trace of the first stimulus, and must postpone the decision report until a sensory cue triggers the beginning of the decision motor report. The neuronal processes associated with the different components of this task have been investigated in the primary auditory cortex (A1); but, A1 seems exclusively associated with the sensory and not with the working memory and decision components of this task. Here, we show that ventral premotor cortex (VPC) neurons reflect in their activities the current and remembered acoustic stimulus, their comparison, and the result of the animal's decision report. These results provide evidence that the neural dynamics of VPC is involved in the processing steps that link sensation and decision-making during auditory discrimination. PMID:19667191

  17. Algebraic Topology

    OpenAIRE

    2013-01-01

    The chapter provides an introduction to the basic concepts of Algebraic Topology with an emphasis on motivation from applications in the physical sciences. It finishes with a brief review of computational work in algebraic topology, including persistent homology.

  18. Effective connectivity analysis demonstrates involvement of premotor cortex during speech perception.

    Science.gov (United States)

    Osnes, Berge; Hugdahl, Kenneth; Specht, Karsten

    2011-02-01

    Several reports of premotor cortex involvement in speech perception have been put forward. Still, the functional role of premotor cortex is under debate. In order to investigate the functional role of premotor cortex, we presented parametrically varied speech stimuli in both a behavioral and functional magnetic resonance imaging (fMRI) study. White noise was transformed over seven distinct steps into a speech sound and presented to the participants in a randomized order. As control condition served the same transformation from white noise into a music instrument sound. The fMRI data were modelled with Dynamic Causal Modeling (DCM) where the effective connectivity between Heschl's gyrus, planum temporale, superior temporal sulcus and premotor cortex were tested. The fMRI results revealed a graded increase in activation in the left superior temporal sulcus. Premotor cortex activity was only present at an intermediate step when the speech sounds became identifiable but were still distorted but was not present when the speech sounds were clearly perceivable. A Bayesian model selection procedure favored a model that contained significant interconnections between Heschl's gyrus, planum temporal, and superior temporal sulcus when processing speech sounds. In addition, bidirectional connections between premotor cortex and superior temporal sulcus and from planum temporale to premotor cortex were significant. Processing non-speech sounds initiated no significant connections to premotor cortex. Since the highest level of motor activity was observed only when processing identifiable sounds with incomplete phonological information, it is concluded that premotor cortex is not generally necessary for speech perception but may facilitate interpreting a sound as speech when the acoustic input is sparse.

  19. Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease

    DEFF Research Database (Denmark)

    Herz, Damian M; Siebner, Hartwig R; Hulme, Oliver J

    2014-01-01

    ), lateral premotor cortex (lPM), supplementary motor area (SMA) and primary motor cortex (M1). Dynamic causal modelling was used to characterize task-related oscillatory coupling between prefrontal and premotor cortical areas. Healthy participants showed task-induced coupling from PFC to SMA, which...... was modulated within the γ-band. In the OFF state, PD patients did not express any frequency-specific coupling between prefrontal and premotor areas. Application of levodopa reinstated task-related coupling from PFC to SMA, which was expressed as high-β-γ coupling. Additionally, strong within-frequency γ...

  20. 适用于拓扑调整的短路电流快速计算方法%A method of fast short-circuit current calculation for topology adjustment

    Institute of Scientific and Technical Information of China (English)

    冯树海; 於益军; 王礼文; 石飞; 汤必强

    2014-01-01

    传统的适用于电网运行方式调整的短路电流计算方法耗时太长,无法满足电网快速分析决策的需求。在此背景下,提出了适用于电网拓扑调整的短路电流快速计算方法。该算法基于节点阻抗矩阵,采用补偿法分析发电机停运、线路开断和线路出串运行导致的阻抗矩阵变化,并在此基础上给出了适用于电网拓扑调整的短路电流快速计算流程。针对不同节点规模的实际系统的仿真算例表明,所提出的方法计算速度快,计算结果准确可靠,能够满足大电网方式调整优化对短路电流计算的要求。该方法可以为电网短路电流限制策略分析提供技术支撑。%The traditional method of the short-circuit current calculation, which is used for the operation mode arrangement, costs too much time. It cannot meet the demand of fast analysis and decision-making. Therefore, a fast algorithm of short-circuit current calculation that is applicable to the grid topology adjustment is put forward. Based on the node impedance matrix and compensation method, it can analyze the changes of impedance matrix caused by the generator outage, line outage and line out series, and based on which the calculation procedure is given. The performance of the proposed method is demonstrated by tests on several real power systems. The simulation results show that the proposed method is fast and accurate, and it can meet the demand of the operation mode arrangement of large-scale power systems. Furthermore, this method is able to provide the technical support for the measure analysis of the short-circuit current limitation.

  1. Topology optimised wavelength dependent splitters

    DEFF Research Database (Denmark)

    Hede, K. K.; Burgos Leon, J.; Frandsen, Lars Hagedorn

    A photonic crystal wavelength dependent splitter has been constructed by utilising topology optimisation1. The splitter has been fabricated in a silicon-on-insulator material (Fig. 1). The topology optimised wavelength dependent splitter demonstrates promising 3D FDTD simulation results....... This complex photonic crystal structure is very sensitive against small fabrication variations from the expected topology optimised design. A wavelength dependent splitter is an important basic building block for high-performance nanophotonic circuits. 1J. S. Jensen and O. Sigmund, App. Phys. Lett. 84, 2022...

  2. Topology optimised wavelength dependent splitters

    DEFF Research Database (Denmark)

    Hede, K. K.; Burgos Leon, J.; Frandsen, Lars Hagedorn;

    A photonic crystal wavelength dependent splitter has been constructed by utilising topology optimisation1. The splitter has been fabricated in a silicon-on-insulator material (Fig. 1). The topology optimised wavelength dependent splitter demonstrates promising 3D FDTD simulation results....... This complex photonic crystal structure is very sensitive against small fabrication variations from the expected topology optimised design. A wavelength dependent splitter is an important basic building block for high-performance nanophotonic circuits. 1J. S. Jensen and O. Sigmund, App. Phys. Lett. 84, 2022...

  3. Introduction to multiple current system of electrical locomotive main circuit topology structure%浅谈多流制电力机车主电路拓扑结构

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      随着经济的发展,世界铁路多种电流制式电力机车跨界运输越来越常见,地区铁路与城市轨道交通互通连接也成为一种发展趋势。但国内对双流制电力机车的研究还处于起步阶段。文章介绍了三种欧洲典型的多流制电力机车主电路拓扑结构和主要特点,并进行了简要的对比和分析。%With the development of economy ,the world railway multiple current system electrical locomotive cross -border transporta-tion is more and more common ,regional railway and urban rail transit also has become a development trend of each connection .But the domestic study of multiple current system electrical locomotive is still in its infancy .This paper introduces the three kinds of typical Eu-ropean multi-current system of electrical locomotive main circuit topology structure and the main features ,and a brief comparison and analysis .

  4. A linear circuit analysis program with stiff systems capability

    Science.gov (United States)

    Cook, C. H.; Bavuso, S. J.

    1973-01-01

    Several existing network analysis programs have been modified and combined to employ a variable topological approach to circuit translation. Efficient numerical integration techniques are used for transient analysis.

  5. Topological insulators and topological superconductors

    CERN Document Server

    Bernevig, Andrei B

    2013-01-01

    This graduate-level textbook is the first pedagogical synthesis of the field of topological insulators and superconductors, one of the most exciting areas of research in condensed matter physics. Presenting the latest developments, while providing all the calculations necessary for a self-contained and complete description of the discipline, it is ideal for graduate students and researchers preparing to work in this area, and it will be an essential reference both within and outside the classroom. The book begins with simple concepts such as Berry phases, Dirac fermions, Hall conductance and its link to topology, and the Hofstadter problem of lattice electrons in a magnetic field. It moves on to explain topological phases of matter such as Chern insulators, two- and three-dimensional topological insulators, and Majorana p-wave wires. Additionally, the book covers zero modes on vortices in topological superconductors, time-reversal topological superconductors, and topological responses/field theory and topolo...

  6. Transcallosal connection patterns of opposite dorsal premotor regions support a lateralized specialization for action and perception

    NARCIS (Netherlands)

    van der Hoorn, Anouk; Potgieser, Adriaan R. E.; de Jong, Bauke M.

    Lateralization of higher brain functions requires that a dominant hemisphere collects relevant information from both sides. The right dorsal premotor cortex (PMd), particularly implicated in visuomotor transformations, was hypothesized to be optimally located to converge visuospatial information

  7. Topological Methods for Visualization

    Energy Technology Data Exchange (ETDEWEB)

    Berres, Anne Sabine [Los Alamos National Lab. (LANL), Los Alamos, NM (United Stat

    2016-04-07

    This slide presentation describes basic topological concepts, including topological spaces, homeomorphisms, homotopy, betti numbers. Scalar field topology explores finding topological features and scalar field visualization, and vector field topology explores finding topological features and vector field visualization.

  8. Grasp movement decoding from premotor and parietal cortex.

    Science.gov (United States)

    Townsend, Benjamin R; Subasi, Erk; Scherberger, Hansjörg

    2011-10-05

    Despite recent advances in harnessing cortical motor-related activity to control computer cursors and robotic devices, the ability to decode and execute different grasping patterns remains a major obstacle. Here we demonstrate a simple Bayesian decoder for real-time classification of grip type and wrist orientation in macaque monkeys that uses higher-order planning signals from anterior intraparietal cortex (AIP) and ventral premotor cortex (area F5). Real-time decoding was based on multiunit signals, which had similar tuning properties to cells in previous single-unit recording studies. Maximum decoding accuracy for two grasp types (power and precision grip) and five wrist orientations was 63% (chance level, 10%). Analysis of decoder performance showed that grip type decoding was highly accurate (90.6%), with most errors occurring during orientation classification. In a subsequent off-line analysis, we found small but significant performance improvements (mean, 6.25 percentage points) when using an optimized spike-sorting method (superparamagnetic clustering). Furthermore, we observed significant differences in the contributions of F5 and AIP for grasp decoding, with F5 being better suited for classification of the grip type and AIP contributing more toward decoding of object orientation. However, optimum decoding performance was maximal when using neural activity simultaneously from both areas. Overall, these results highlight quantitative differences in the functional representation of grasp movements in AIP and F5 and represent a first step toward using these signals for developing functional neural interfaces for hand grasping.

  9. Beginning topology

    CERN Document Server

    Goodman, Sue E

    2009-01-01

    Beginning Topology is designed to give undergraduate students a broad notion of the scope of topology in areas of point-set, geometric, combinatorial, differential, and algebraic topology, including an introduction to knot theory. A primary goal is to expose students to some recent research and to get them actively involved in learning. Exercises and open-ended projects are placed throughout the text, making it adaptable to seminar-style classes. The book starts with a chapter introducing the basic concepts of point-set topology, with examples chosen to captivate students' imaginations while i

  10. Brain-machine interface circuits and systems

    CERN Document Server

    Zjajo, Amir

    2016-01-01

    This book provides a complete overview of significant design challenges in respect to circuit miniaturization and power reduction of the neural recording system, along with circuit topologies, architecture trends, and (post-silicon) circuit optimization algorithms. The introduced novel circuits for signal conditioning, quantization, and classification, as well as system configurations focus on optimized power-per-area performance, from the spatial resolution (i.e. number of channels), feasible wireless data bandwidth and information quality to the delivered power of implantable system.

  11. Topology Zero: Advancing Theory and Experimentation for Power Electronics Education

    Science.gov (United States)

    Luchino, Federico

    For decades, power electronics education has been based on the fundamentals of three basic topologies: buck, boost, and buck-boost. This thesis presents the analytical framework for the Topology Zero, a general circuit topology that integrates the basic topologies and provides significant insight into the behaviour of converters. As demonstrated, many topologies are just particular cases of the Topology Zero, an important contribution towards the understanding, integration, and conceptualization of topologies. The investigation includes steady-state, small-signal, and frequency response analysis. The Topology Zero is physically implemented as an educational system. Experimental results are presented to show control applications and power losses analysis using the educational system. The steady-state and dynamic analyses of the Topology Zero provide profuse proof of its suitability as an integrative topology, and of its ability to be indirectly controlled. As well, the implementation of the Topology Zero within an experimentation system is explained and application examples are provided.

  12. Calretinin as a marker for premotor neurons involved in upgaze in human brainstem

    Directory of Open Access Journals (Sweden)

    Christopher eAdamczyk

    2015-12-01

    Full Text Available Eye movements are generated by different premotor pathways. Damage to them can cause specific deficits of eye movements, such as saccades. For correlative clinico-anatomical post-mortem studies of cases with eye movement disorders it is essential to identify the functional cell groups of the oculomotor system in the human brain by marker proteins. Based on monkey studies, the premotor neurons of the saccadic system can be identified by the histochemical markers parvalbumin and perineuronal nets in humans. These areas involve the interstitial nucleus of Cajal (INC and the rostral interstitial nucleus of the medial longitudinal fascicle (RIMLF, which both contain premotor neurons for upgaze and downgaze. Recent monkey and human studies revealed a selective excitatory calretinin-positive input to the motoneurons mediating upgaze, but not to those for downgaze. Three premotor regions were identified as sources of calretinin input in monkey: y-group, INC and RIMLF. These findings suggest that the expression pattern of parvalbumin and calretinin may help to identify premotor neurons involved in up- or downgaze. In a post-mortem study of five human cases without neurological diseases we investigated the y-group, INC and RIMLF for the presence of parvalbumin and calretinin positive neurons including their co-expression. Adjacent thin paraffin sections were stained for the aggrecan component of perineuronal nets, parvalbumin or calretinin and glutamate decarboxylase. The comparative analysis of scanned thin sections of INC and RIMLF revealed medium-sized parvalbumin positive neurons with and without calretinin coexpression, which were intermingled. The parvalbumin/calretinin positive neurons in both nuclei are considered as excitatory premotor upgaze neurons. Accordingly, the parvalbumin-positive neurons lacking calretinin are considered as premotor downgaze neurons in RIMLF, but may in addition include inhibitory premotor upgaze neurons in the INC as

  13. Ultra low power full adder topologies

    DEFF Research Database (Denmark)

    Moradi, Farshad; Wisland, Dag T.; Mahmoodi, Hamid

    In this paper several low power full adder topologies are presented. The main idea of these circuits is based on the sense energy recovery full adder (SERF) design and the GDI (gate diffusion input) technique. These subthreshold circuits are employed for ultra low power applications. While...

  14. Cardiovascular physiology in premotor Parkinson's disease: a neuroepidemiologic study.

    Science.gov (United States)

    Jain, Samay; Ton, Thanh G; Perera, Subashan; Zheng, Yan; Stein, Phyllis K; Thacker, Evan; Strotmeyer, Elsa S; Newman, Anne B; Longstreth, Will T

    2012-07-01

    Changes in cardiovascular physiology in Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, and carotid stenosis with the risk of PD diagnosis in the Cardiovascular Health Study, a community-based cohort of older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24-hour Holter monitoring), and any carotid stenosis (≥1%) by ultrasound were modeled as primary predictors of incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least 1 of the following: self-report, antiparkinsonian medication use, and ICD-9. If unadjusted models were significant, they were adjusted or stratified by age, sex, and smoking status, and those in which predictors were still significant (P ≤ .05) were also adjusted for race, diabetes, total cholesterol, low-density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke, and C-reactive protein. Of 5888 participants, 154 incident PD cases were identified over 14 years of follow-up. After adjusting models with all covariates, those with any ECG abnormality (odds ratio [OR], 1.45; 95% CI, 1.02-2.07; P = .04) or any carotid stenosis (OR, 2.40; 95% CI, 1.40-4.09; P = .001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential premotor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset.

  15. Writer's cramp: increased dorsal premotor activity during intended writing.

    Science.gov (United States)

    Delnooz, Cathérine C S; Helmich, Rick C; Medendorp, W P; Van de Warrenburg, Bart P C; Toni, Ivan

    2013-03-01

    Simple writer's cramp (WC) is a task-specific form of dystonia, characterized by abnormal movements and postures of the hand during writing. It is extremely task-specific, since dystonic symptoms can occur when a patient uses a pencil for writing, but not when it is used for sharpening. Maladaptive plasticity, loss of inhibition, and abnormal sensory processing are important pathophysiological elements of WC. However, it remains unclear how those elements can account for its task-specificity. We used fMRI to isolate cerebral alterations associated with the task-specificity of simple WC. Subjects (13 simple WC patients, 20 matched controls) imagined grasping a pencil to either write with it or sharpen it. On each trial, we manipulated the pencil's position and the number of imagined movements, while monitoring variations in motor output with electromyography. We show that simple WC is characterized by abnormally increased activity in the dorsal premotor cortex (PMd) when imagined actions are specifically related to writing. This cerebral effect was independent from the known deficits in dystonia in generating focal motor output and in processing somatosensory feedback. This abnormal activity of the PMd suggests that the task-specific element of simple WC is primarily due to alterations at the planning level, in the computations that transform a desired action outcome into the motor commands leading to that action. These findings open the way for testing the therapeutic value of interventions that take into account the computational substrate of task-specificity in simple WC, e.g. modulations of PMd activity during the planning phase of writing.

  16. Integrated circuits for multimedia applications

    DEFF Research Database (Denmark)

    Vandi, Luca

    2007-01-01

    This work presents several key aspects in the design of RF integrated circuits for portable multimedia devices. One chapter is dedicated to the application of negative-feedback topologies to receiver frontends. A novel feedback technique suitable for common multiplier-based mixers is described......, and it is applied to a broad-band dual-loop receiver architecture in order to boost the linearity performances of the stage. A simplified noise- and linearity analysis of the circuit is derived, and a comparison is provided with a more traditional dual-loop topology (a broad-band stage based on shunt...

  17. Lateral power transistors in integrated circuits

    CERN Document Server

    Erlbacher, Tobias

    2014-01-01

    This book details and compares recent advancements in the development of novel lateral power transistors (LDMOS devices) for integrated circuits in power electronic applications. It includes the state-of-the-art concept of double-acting RESURF topologies.

  18. α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects.

    Science.gov (United States)

    Kim, Joong-Seok; Park, In-Seok; Park, Hyung-Eun; Kim, Su-Young; Yun, Jung A; Jung, Chan Kwon; Sung, Hye-Young; Lee, Jin-Kwon; Kang, Won-Kyung

    2017-01-01

    Extranigral non-motor signs precede the first motor manifestations of Parkinson's disease by many years in some patients. The presence of α-synuclein deposition within colon tissues in patients with Parkinson's disease can aid in identifying early neuropathological changes prior to disease onset. In the present study, we evaluated the roles of non-motor symptoms and signs and imaging biomarkers of nigral neuronal changes and α-synuclein accumulation in the colon. Twelve subjects undergoing colectomy for primary colon cancer were recruited for this study. Immunohistochemical staining for α-synuclein in normal and phosphorylated forms was performed in normally appearing colonic tissue. We evaluated 16 candidate premotor risk factors in this study cohort. Among them, ten subjects showed positive immunostaining with normal- and phosphorylated-α-synuclein. An accumulation of premotor markers in each subject was accompanied with positive normal- and phosphorylated-α-synuclein immunostaining, ranging from 2 to 7 markers per subject, whereas the absence of Lewy bodies in the colon was associated with relative low numbers of premotor signs. A principal component analysis and a cluster analysis of these premotor markers suggest that urinary symptoms were commonly clustered with deposition of peripheral phosphorylated-α-synuclein. Among other premotor marker, color vision abnormalities were related to non-smoking. This mathematical approach confirmed the clustering of premotor markers in preclinical stage of Parkinson's disease. This is the first report showing that α-synuclein in the colon and other premotor markers are related to each other in neurologically normal subjects.

  19. Multisensory and Modality Specific Processing of Visual Speech in Different Regions of the Premotor Cortex

    Directory of Open Access Journals (Sweden)

    Daniel eCallan

    2014-05-01

    Full Text Available Behavioral and neuroimaging studies have demonstrated that brain regions involved with speech production also support speech perception, especially under degraded conditions. The premotor cortex has been shown to be active during both observation and execution of action (‘Mirror System’ properties, and may facilitate speech perception by mapping unimodal and multimodal sensory features onto articulatory speech gestures. For this functional magnetic resonance imaging (fMRI study, participants identified vowels produced by a speaker in audio-visual (saw the speaker’s articulating face and heard her voice, visual only (only saw the speaker’s articulating face, and audio only (only heard the speaker’s voice conditions with varying audio signal-to-noise ratios in order to determine the regions of the premotor cortex involved with multisensory and modality specific processing of visual speech gestures. The task was designed so that identification could be made with a high level of accuracy from visual only stimuli to control for task difficulty and differences in intelligibility. The results of the fMRI analysis for visual only and audio-visual conditions showed overlapping activity in inferior frontal gyrus and premotor cortex. The left ventral inferior premotor cortex showed properties of multimodal (audio-visual enhancement with a degraded auditory signal. The left inferior parietal lobule and right cerebellum also showed these properties. The left ventral superior and dorsal premotor cortex did not show this multisensory enhancement effect, but there was greater activity for the visual only over audio-visual conditions in these areas. The results suggest that the inferior regions of the ventral premotor cortex are involved with integrating multisensory information, whereas, more superior and dorsal regions of the premotor cortex are involved with mapping unimodal (in this case visual sensory features of the speech signal with

  20. Automated Design of Quantum Circuits

    Science.gov (United States)

    Williams, Colin P.; Gray, Alexander G.

    2000-01-01

    In order to design a quantum circuit that performs a desired quantum computation, it is necessary to find a decomposition of the unitary matrix that represents that computation in terms of a sequence of quantum gate operations. To date, such designs have either been found by hand or by exhaustive enumeration of all possible circuit topologies. In this paper we propose an automated approach to quantum circuit design using search heuristics based on principles abstracted from evolutionary genetics, i.e. using a genetic programming algorithm adapted specially for this problem. We demonstrate the method on the task of discovering quantum circuit designs for quantum teleportation. We show that to find a given known circuit design (one which was hand-crafted by a human), the method considers roughly an order of magnitude fewer designs than naive enumeration. In addition, the method finds novel circuit designs superior to those previously known.

  1. Toric topology

    CERN Document Server

    Buchstaber, Victor M

    2015-01-01

    This book is about toric topology, a new area of mathematics that emerged at the end of the 1990s on the border of equivariant topology, algebraic and symplectic geometry, combinatorics, and commutative algebra. It has quickly grown into a very active area with many links to other areas of mathematics, and continues to attract experts from different fields. The key players in toric topology are moment-angle manifolds, a class of manifolds with torus actions defined in combinatorial terms. Construction of moment-angle manifolds relates to combinatorial geometry and algebraic geometry of toric v

  2. Topological Manifolds

    Directory of Open Access Journals (Sweden)

    Pąk Karol

    2015-02-01

    Full Text Available Let us recall that a topological space M is a topological manifold if M is second-countable Hausdorff and locally Euclidean, i.e. each point has a neighborhood that is homeomorphic to an open ball of E n for some n. However, if we would like to consider a topological manifold with a boundary, we have to extend this definition. Therefore, we introduce here the concept of a locally Euclidean space that covers both cases (with and without a boundary, i.e. where each point has a neighborhood that is homeomorphic to a closed ball of En for some n.

  3. Topological insulators

    CERN Document Server

    Franz, Marcel

    2013-01-01

    Topological Insulators, volume six in the Contemporary Concepts of Condensed Matter Series, describes the recent revolution in condensed matter physics that occurred in our understanding of crystalline solids. The book chronicles the work done worldwide that led to these discoveries and provides the reader with a comprehensive overview of the field. Starting in 2004, theorists began to explore the effect of topology on the physics of band insulators, a field previously considered well understood. However, the inclusion of topology brings key new elements into this old field. Whereas it was

  4. Topological fields

    CERN Document Server

    Warner, S

    1989-01-01

    Aimed at those acquainted with basic point-set topology and algebra, this text goes up to the frontiers of current research in topological fields (more precisely, topological rings that algebraically are fields).The reader is given enough background to tackle the current literature without undue additional preparation. Many results not in the text (and many illustrations by example of theorems in the text) are included among the exercises. Sufficient hints for the solution of the exercises are offered so that solving them does not become a major research effort for the reader. A comprehensive bibliography completes the volume.

  5. The importance of premotor cortex for supporting speech production after left capsular-putaminal damage.

    Science.gov (United States)

    Seghier, Mohamed L; Bagdasaryan, Juliana; Jung, Dorit E; Price, Cathy J

    2014-10-22

    The left putamen is known to be important for speech production, but some patients with left putamen damage can produce speech remarkably well. We investigated the neural mechanisms that support this recovery by using a combination of techniques to identify the neural regions and pathways that compensate for loss of the left putamen during speech production. First, we used fMRI to identify the brain regions that were activated during reading aloud and picture naming in a patient with left putamen damage. This revealed that the patient had abnormally high activity in the left premotor cortex. Second, we used dynamic causal modeling of the patient's fMRI data to understand how this premotor activity influenced other speech production regions and whether the same neural pathway was used by our 24 neurologically normal control subjects. Third, we validated the compensatory relationship between putamen and premotor cortex by showing, in the control subjects, that lower connectivity through the putamen increased connectivity through premotor cortex. Finally, in a lesion-deficit analysis, we demonstrate the explanatory power of our fMRI results in new patients who had damage to the left putamen, left premotor cortex, or both. Those with damage to both had worse reading and naming scores. The results of our four-pronged approach therefore have clinical implications for predicting which patients are more or less likely to recover their speech after left putaminal damage. Copyright © 2014 Seghier et al.

  6. Algebraic circuits

    CERN Document Server

    Lloris Ruiz, Antonio; Parrilla Roure, Luis; García Ríos, Antonio

    2014-01-01

    This book presents a complete and accurate study of algebraic circuits, digital circuits whose performance can be associated with any algebraic structure. The authors distinguish between basic algebraic circuits, such as Linear Feedback Shift Registers (LFSRs) and cellular automata, and algebraic circuits, such as finite fields or Galois fields. The book includes a comprehensive review of representation systems, of arithmetic circuits implementing basic and more complex operations, and of the residue number systems (RNS). It presents a study of basic algebraic circuits such as LFSRs and cellular automata as well as a study of circuits related to Galois fields, including two real cryptographic applications of Galois fields.

  7. Differential topology

    CERN Document Server

    Mukherjee, Amiya

    2015-01-01

    This book presents a systematic and comprehensive account of the theory of differentiable manifolds and provides the necessary background for the use of fundamental differential topology tools. The text includes, in particular, the earlier works of Stephen Smale, for which he was awarded the Fields Medal. Explicitly, the topics covered are Thom transversality, Morse theory, theory of handle presentation, h-cobordism theorem, and the generalised Poincaré conjecture. The material is the outcome of lectures and seminars on various aspects of differentiable manifolds and differential topology given over the years at the Indian Statistical Institute in Calcutta, and at other universities throughout India. The book will appeal to graduate students and researchers interested in these topics. An elementary knowledge of linear algebra, general topology, multivariate calculus, analysis, and algebraic topology is recommended.

  8. Topology Optimization

    DEFF Research Database (Denmark)

    A. Kristensen, Anders Schmidt; Damkilde, Lars

    2007-01-01

    . A way to solve the initial design problem namely finding a form can be solved by so-called topology optimization. The idea is to define a design region and an amount of material. The loads and supports are also fidefined, and the algorithm finds the optimal material distribution. The objective function...... dictates the form, and the designer can choose e.g. maximum stiness, maximum allowable stresses or maximum lowest eigenfrequency. The result of the topology optimization is a relatively coarse map of material layout. This design can be transferred to a CAD system and given the necessary geometrically...... refinements, and then remeshed and reanalysed in other to secure that the design requirements are met correctly. The output of standard topology optimization has seldom well-defined, sharp contours leaving the designer with a tedious interpretation, which often results in less optimal structures. In the paper...

  9. Topological rings

    CERN Document Server

    Warner, S

    1993-01-01

    This text brings the reader to the frontiers of current research in topological rings. The exercises illustrate many results and theorems while a comprehensive bibliography is also included. The book is aimed at those readers acquainted with some very basic point-set topology and algebra, as normally presented in semester courses at the beginning graduate level or even at the advanced undergraduate level. Familiarity with Hausdorff, metric, compact and locally compact spaces and basic properties of continuous functions, also with groups, rings, fields, vector spaces and modules, and with Zorn''s Lemma, is also expected.

  10. Pseudoperiodic topology

    CERN Document Server

    Arnold, Vladimir; Zorich, Anton

    1999-01-01

    This volume offers an account of the present state of the art in pseudoperiodic topology-a young branch of mathematics, born at the boundary between the ergodic theory of dynamical systems, topology, and number theory. Related topics include the theory of algorithms, convex integer polyhedra, Morse inequalities, real algebraic geometry, statistical physics, and algebraic number theory. The book contains many new results. Most of the articles contain brief surveys on the topics, making the volume accessible to a broad audience. From the Preface by V.I. Arnold: "The authors … have done much to s

  11. Topology essentials

    CERN Document Server

    Milewski, Emil G

    2013-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Topology includes an overview of elementary set theory, relations and functions, ordinals and cardinals, topological spaces, continuous functions, metric spaces and normed spaces, co

  12. Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease

    DEFF Research Database (Denmark)

    Herz, Damian Marc; Florin, Esther; Christensen, Mark Schram;

    2014-01-01

    Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive...

  13. The primary motor and premotor areas of the human cerebral cortex.

    Science.gov (United States)

    Chouinard, Philippe A; Paus, Tomás

    2006-04-01

    Brodmann's cytoarchitectonic map of the human cortex designates area 4 as cortex in the anterior bank of the precentral sulcus and area 6 as cortex encompassing the precentral gyrus and the posterior portion of the superior frontal gyrus on both the lateral and medial surfaces of the brain. More than 70 years ago, Fulton proposed a functional distinction between these two areas, coining the terms primary motor area for cortex in Brodmann area 4 and premotor area for cortex in Brodmann area 6. The parcellation of the cortical motor system has subsequently become more complex. Several nonprimary motor areas have been identified in the brain of the macaque monkey, and associations between anatomy and function in the human brain are being tested continuously using brain mapping techniques. In the present review, the authors discuss the unique properties of the primary motor area (M1), the dorsal portion of the premotor cortex (PMd), and the ventral portion of the premotor cortex (PMv). They end this review by discussing how the premotor areas influence M1.

  14. The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?

    NARCIS (Netherlands)

    Rueb, U.; Heinsen, H.; Brunt, E. R.; Landwehrmeyer, B.; Den Dunnen, W. F. A.; Gierga, K.; Deller, T.

    2009-01-01

    Recent progress in oculomotor research has enabled new insights into the functional neuroanatomy of the human premotor oculomotor brainstem network. In the present review, we provide an overview of its functional neuroanatomy and summarize the broad range of oculomotor dysfunctions that may occur in

  15. Charting the excitability of premotor to motor connections while withholding or initiating a selected movement

    DEFF Research Database (Denmark)

    Kroeger, Johan; Bäumer, Tobias; Jonas, Melanie

    2010-01-01

    In 19 healthy volunteers, we used transcranial magnetic stimulation (TMS) to probe the excitability in pathways linking the left dorsal premotor cortex and right primary motor cortex and those linking the left and right motor cortex during the response delay and the reaction time period while sub...

  16. Continuous Theta-Burst Stimulation Demonstrates a Causal Role of Premotor Homunculus in Action Understanding

    DEFF Research Database (Denmark)

    Michael, John; Sandberg, Kristian; Skewes, Joshua

    2014-01-01

    Although it is well established that regions of premotor cortex (PMC) are active during action observation, it remains controversial whether they play a causal role in action understanding. In the experiment reported here, we used offline continuous theta-burst stimulation (cTBS) to investigate...

  17. Uncovering a context-specific connectional fingerprint of human dorsal premotor cortex

    DEFF Research Database (Denmark)

    Moisa, Marius; Siebner, Hartwig R; Pohmann, Rolf

    2012-01-01

    Primate electrophysiological and lesion studies indicate a prominent role of the left dorsal premotor cortex (PMd) in action selection based on learned sensorimotor associations. Here we applied transcranial magnetic stimulation (TMS) to human left PMd at low or high intensity while right-handed ...

  18. Continuous Theta-Burst Stimulation Demonstrates a Causal Role of Premotor Homunculus in Action Understanding

    DEFF Research Database (Denmark)

    Michael, John; Sandberg, Kristian; Skewes, Joshua

    2014-01-01

    Although it is well established that regions of premotor cortex (PMC) are active during action observation, it remains controversial whether they play a causal role in action understanding. In the experiment reported here, we used offline continuous theta-burst stimulation (cTBS) to investigate t...

  19. TMS-Induced Modulation of Action Sentence Priming in the Ventral Premotor Cortex

    Science.gov (United States)

    Tremblay, Pascale; Sato, Marc; Small, Steven L.

    2012-01-01

    Despite accumulating evidence that cortical motor areas, particularly the lateral premotor cortex, are activated during language comprehension, the question of whether motor processes help mediate the semantic encoding of language remains controversial. To address this issue, we examined whether low frequency (1 Hz) repetitive transcranial…

  20. Algebraic Topology

    CERN Document Server

    Oliver, Bob; Pawałowski, Krzystof

    1991-01-01

    As part of the scientific activity in connection with the 70th birthday of the Adam Mickiewicz University in Poznan, an international conference on algebraic topology was held. In the resulting proceedings volume, the emphasis is on substantial survey papers, some presented at the conference, some written subsequently.

  1. Topology optimization

    DEFF Research Database (Denmark)

    Bendsøe, Martin P.; Sigmund, Ole

    2007-01-01

    Taking as a starting point a design case for a compliant mechanism (a force inverter), the fundamental elements of topology optimization are described. The basis for the developments is a FEM format for this design problem and emphasis is given to the parameterization of design as a raster image...

  2. RNA topology

    OpenAIRE

    Frank-Kamenetskii, Maxim D.

    2013-01-01

    A new variety on non-coding RNA has been discovered by several groups: circular RNA (circRNA). This discovery raises intriguing questions about the possibility of the existence of knotted RNA molecules and the existence of a new class of enzymes changing RNA topology, RNA topoisomerases.

  3. Homotopical topology

    CERN Document Server

    Fomenko, Anatoly

    2016-01-01

    This classic text of the renowned Moscow mathematical school equips the aspiring mathematician with a solid grounding in the core of topology, from a homotopical perspective. Its comprehensiveness and depth of treatment are unmatched among topology textbooks: in addition to covering the basics—the fundamental notions and constructions of homotopy theory, covering spaces and the fundamental group, CW complexes, homology and cohomology, homological algebra—the book treats essential advanced topics, such as obstruction theory, characteristic classes, Steenrod squares, K-theory and cobordism theory, and, with distinctive thoroughness and lucidity, spectral sequences. The organization of the material around the major achievements of the golden era of topology—the Adams conjecture, Bott periodicity, the Hirzebruch–Riemann–Roch theorem, the Atiyah–Singer index theorem, to name a few—paints a clear picture of the canon of the subject. Grassmannians, loop spaces, and classical groups play a central role ...

  4. Synaptic polarity of the interneuron circuit controlling C. elegans locomotion

    Directory of Open Access Journals (Sweden)

    Franciszek eRakowski

    2013-10-01

    Full Text Available C. elegans is the only animal for which a detailed neural connectivity diagram has been constructed. However, synaptic polarities in this diagram, and thus, circuit functions are largely unknown. Here, we deciphered the likely polarities of 7 pre-motor neurons implicated in the control of worm's locomotion, using a combination of experimental and computational tools. We performed single and multiple laser ablations in the locomotor interneuron circuit and recorded times the worms spent in forward and backward locomotion. We constructed a theoretical model of the locomotor circuit and searched its all possible synaptic polarity combinations and sensory input patterns in order to find the best match to the timing data. The optimal solution is when either all or most of the interneurons are inhibitory and forward interneurons receive the strongest input, which suggests that inhibition governs the dynamics of the locomotor interneuron circuit. From the five pre-motor interneurons, only AVB and AVD are equally likely to be excitatory, i.e. they have probably similar number of inhibitory and excitatory connections to distant targets. The method used here has a general character and thus can be also applied to other neural systems consisting of small functional networks.

  5. Synaptic polarity of the interneuron circuit controlling C. elegans locomotion.

    Science.gov (United States)

    Rakowski, Franciszek; Srinivasan, Jagan; Sternberg, Paul W; Karbowski, Jan

    2013-01-01

    Caenorhabditis elegans is the only animal for which a detailed neural connectivity diagram has been constructed. However, synaptic polarities in this diagram, and thus, circuit functions are largely unknown. Here, we deciphered the likely polarities of seven pre-motor neurons implicated in the control of worm's locomotion, using a combination of experimental and computational tools. We performed single and multiple laser ablations in the locomotor interneuron circuit and recorded times the worms spent in forward and backward locomotion. We constructed a theoretical model of the locomotor circuit and searched its all possible synaptic polarity combinations and sensory input patterns in order to find the best match to the timing data. The optimal solution is when either all or most of the interneurons are inhibitory and forward interneurons receive the strongest input, which suggests that inhibition governs the dynamics of the locomotor interneuron circuit. From the five pre-motor interneurons, only AVB and AVD are equally likely to be excitatory, i.e., they have probably similar number of inhibitory and excitatory connections to distant targets. The method used here has a general character and thus can be also applied to other neural systems consisting of small functional networks.

  6. Resonance circuits for adiabatic circuits

    Directory of Open Access Journals (Sweden)

    C. Schlachta

    2003-01-01

    Full Text Available One of the possible techniques to reduces the power consumption in digital CMOS circuits is to slow down the charge transport. This slowdown can be achieved by introducing an inductor in the charging path. Additionally, the inductor can act as an energy storage element, conserving the energy that is normally dissipated during discharging. Together with the parasitic capacitances from the circuit a LCresonant circuit is formed.

  7. Decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder.

    Directory of Open Access Journals (Sweden)

    Vanessa Rocha-Rego

    Full Text Available BACKGROUND: Studies addressing posttraumatic stress disorder (PTSD have demonstrated that PTSD patients exhibit structural abnormalities in brain regions that relate to stress regulation and fear responses, such as the hippocampus, amygdala, anterior cingulate cortex, and ventromedial prefrontal cortex. Premotor cortical areas are involved in preparing to respond to a threatening situation and in representing the peripersonal space. Urban violence is an important and pervasive cause of human suffering, especially in large urban centers in the developing world. Violent events, such as armed robbery, are very frequent in certain cities, and these episodes increase the risk of PTSD. Assaultive trauma is characterized by forceful invasion of the peripersonal space; therefore, could this traumatic event be associated with structural alteration of premotor areas in PTSD? METHODOLOGY/PRINCIPAL FINDINGS: Structural magnetic resonance imaging scans were acquired from a sample of individuals that had been exposed to urban violence. This sample consisted of 16 PTSD patients and 16 age- and gender-matched controls. Psychometric questionnaires differentiated PTSD patients from trauma-exposed controls with regard to PTSD symptoms, affective, and resilience predispositions. Voxel-based morphometric analysis revealed that, compared with controls, the PTSD patients presented significant reductions in gray matter volume in the ventral premotor cortex and in the pregenual anterior cingulate cortex. CONCLUSIONS: Volume reduction in the premotor cortex that is observed in victims of urban violence with PTSD may be associated with a disruption in the dynamical modulation of the safe space around the body. The finding that PTSD patients presented a smaller volume of pregenual anterior cingulate cortex is consistent with the results of other PTSD neuroimaging studies that investigated different types of traumatic events.

  8. Multisensory and modality specific processing of visual speech in different regions of the premotor cortex.

    Science.gov (United States)

    Callan, Daniel E; Jones, Jeffery A; Callan, Akiko

    2014-01-01

    Behavioral and neuroimaging studies have demonstrated that brain regions involved with speech production also support speech perception, especially under degraded conditions. The premotor cortex (PMC) has been shown to be active during both observation and execution of action ("Mirror System" properties), and may facilitate speech perception by mapping unimodal and multimodal sensory features onto articulatory speech gestures. For this functional magnetic resonance imaging (fMRI) study, participants identified vowels produced by a speaker in audio-visual (saw the speaker's articulating face and heard her voice), visual only (only saw the speaker's articulating face), and audio only (only heard the speaker's voice) conditions with varying audio signal-to-noise ratios in order to determine the regions of the PMC involved with multisensory and modality specific processing of visual speech gestures. The task was designed so that identification could be made with a high level of accuracy from visual only stimuli to control for task difficulty and differences in intelligibility. The results of the functional magnetic resonance imaging (fMRI) analysis for visual only and audio-visual conditions showed overlapping activity in inferior frontal gyrus and PMC. The left ventral inferior premotor cortex (PMvi) showed properties of multimodal (audio-visual) enhancement with a degraded auditory signal. The left inferior parietal lobule and right cerebellum also showed these properties. The left ventral superior and dorsal premotor cortex (PMvs/PMd) did not show this multisensory enhancement effect, but there was greater activity for the visual only over audio-visual conditions in these areas. The results suggest that the inferior regions of the ventral premotor cortex are involved with integrating multisensory information, whereas, more superior and dorsal regions of the PMC are involved with mapping unimodal (in this case visual) sensory features of the speech signal with

  9. Dorsal premotor cortex and conditional movement selection: A PET functional mapping study.

    Science.gov (United States)

    Grafton, S T; Fagg, A H; Arbib, M A

    1998-02-01

    Positron emission tomography (PET) brain mapping was used to investigate whether or not human dorsal premotor cortex is involved in selecting motor acts based on arbitrary visual stimuli. Normal subjects performed four movement selection tasks. A manipulandum with three graspable stations was used. An imperative visual cue (LEDs illuminated in random order) indicated which station to grasp next with no instructional delay period. In a power task, a large aperture power grip was used for all trials, irrespective of the LED color. In a precision task, a pincer grasp of thumb and index finger was used. In a conditional task, the type of grasp (power or precision) was randomly determined by LED color. Comparison of the conditional selection task versus the average of the power and precision tasks revealed increased blood flow in left dorsal premotor cortex and superior parietal lobule. The average rate of producing the different grasp types and transport to the manipulandum stations was equivalent across this comparison, minimizing the contribution of movement attributes such as planning the individual movements (as distinct from planning associated with use of instructional stimuli), kinematics, or direction of target or limb movement. A comparison of all three movement tasks versus a rest task identified movement related activity involving a large area of central, precentral and postcentral cortex. In the region of the precentral sulcus movement related activity was located immediately caudal to the area activated during selection. The results establish a role for human dorsal premotor cortex and superior parietal cortex in selecting stimulus guided movements and suggest functional segregation within dorsal premotor cortex.

  10. Exploring the contributions of premotor and parietal cortex to spatial compatibility using image-guided TMS.

    Science.gov (United States)

    Koski, Lisa; Molnar-Szakacs, Istvan; Iacoboni, Marco

    2005-01-15

    Functional brain imaging studies have demonstrated increased activity in dorsal premotor and posterior parietal cortex when performing spatial stimulus-response compatibility tasks (SRC). We tested the specific role of these regions in stimulus-response mapping using single-pulse transcranial magnetic stimulation (TMS). Subjects were scanned using functional magnetic resonance imaging (fMRI) prior to the TMS session during performance of a task in which spatial compatibility was manipulated. For each subject, the area of increased signal within the regions of interest was registered onto their own high-resolution T1-weighted anatomic scan. TMS was applied to these areas for each subject using a frameless stereotaxic system. Task accuracy and reaction time (RT) were measured during blocks of compatible or incompatible trials and during blocks of real TMS or sham stimulation. On each trial, a single TMS pulse was delivered at 50, 100, 150, or 200 ms after the onset of the stimulus in the left or right visual field. TMS over the left premotor cortex produced various facilitatory effects, depending on the timing of the stimulation. At short intervals, TMS appeared to prime the left dorsal premotor cortex to select a right-hand response more quickly, regardless of stimulus-response compatibility. The strongest effect of stimulation, however, occurred at the 200-ms interval, when TMS facilitated left-hand responses during the incompatible condition. Facilitation of attention to the contralateral visual hemifield was observed during stimulation over the parietal locations. We conclude that the left premotor cortex is one of the cortical regions responsible for overriding automatic stimulus-response associations.

  11. It's how you get there: Walking down a virtual alley activates premotor and parietal areas

    Directory of Open Access Journals (Sweden)

    Johanna eWagner

    2014-02-01

    Full Text Available Voluntary drive is crucial for motor learning, therefore we are interested in the role that motor planning plays in gait movements. In this study we examined the impact of an interactive Virtual Environment (VE feedback task on the EEG patterns during robot assisted walking. We compared walking in the VE modality to two control conditions: walking with a visual attention paradigm, in which visual stimuli were unrelated to the motor task; and walking with mirror feedback, in which participants observed their own movements. Eleven healthy participants were considered. Application of independent component analysis to the EEG revealed three independent component clusters in premotor and parietal areas showing increased activity during walking with the adaptive VE training paradigm compared to the control conditions. During the interactive VE walking task spectral power in frequency ranges 8-12Hz, 15-20Hz and 23-40Hz was significantly (p ≤ 0.05 decreased. This power decrease is interpreted as a correlate of an active cortical area. Furthermore activity in the premotor cortex revealed gait cycle related modulations significantly different (p ≤ 0.05 from baseline in the frequency range 23-40Hz during walking. These modulations were significantly (p ≤ 0.05 reduced depending on gait cycle phases in the interactive VE walking task compared to the control conditions.We demonstrate that premotor and parietal areas show increased activity during walking with the adaptive VE training paradigm, when compared to walking with mirror- and movement unrelated feedback. Previous research has related a premotor-parietal network to motor planning and motor intention. We argue that movement related interactive feedback enhances motor planning and motor intention. We hypothesize that this might improve gait recovery during rehabilitation.

  12. Differential topology

    CERN Document Server

    Guillemin, Victor

    2010-01-01

    Differential Topology provides an elementary and intuitive introduction to the study of smooth manifolds. In the years since its first publication, Guillemin and Pollack's book has become a standard text on the subject. It is a jewel of mathematical exposition, judiciously picking exactly the right mixture of detail and generality to display the richness within. The text is mostly self-contained, requiring only undergraduate analysis and linear algebra. By relying on a unifying idea-transversality-the authors are able to avoid the use of big machinery or ad hoc techniques to establish the main

  13. Somatosensory-motor adaptation of orofacial actions in posterior parietal and ventral premotor cortices.

    Directory of Open Access Journals (Sweden)

    Krystyna Grabski

    Full Text Available Recent studies have provided evidence for sensory-motor adaptive changes and action goal coding of visually guided manual action in premotor and posterior parietal cortices. To extend these results to orofacial actions, devoid of auditory and visual feedback, we used a repetition suppression paradigm while measuring neural activity with functional magnetic resonance imaging during repeated intransitive and silent lip, jaw and tongue movements. In the motor domain, this paradigm refers to decreased activity in specific neural populations due to repeated motor acts and has been proposed to reflect sensory-motor adaptation. Orofacial movements activated a set of largely overlapping, common brain areas forming a core neural network classically involved in orofacial motor control. Crucially, suppressed neural responses during repeated orofacial actions were specifically observed in the left ventral premotor cortex, the intraparietal sulcus, the inferior parietal lobule and the superior parietal lobule. Since no visual and auditory feedback were provided during orofacial actions, these results suggest somatosensory-motor adaptive control of intransitive and silent orofacial actions in these premotor and parietal regions.

  14. Coordinated activation of premotor and ventromedial prefrontal cortices during vicarious reward.

    Science.gov (United States)

    Shimada, Sotaro; Matsumoto, Madoka; Takahashi, Hidefumi; Yomogida, Yukihito; Matsumoto, Kenji

    2016-03-01

    The vicarious reward we receive from watching likable others obtaining a positive outcome is a pervasive phenomenon, yet its neural correlates are poorly understood. Here, we conducted a series of functional magnetic resonance imaging experiments to test the hypothesis that the brain areas responsible for action observation and reward processing work in a coordinated fashion during vicarious reward. In the first experiment (manipulation phase), the participant was instructed to cheer for a particular player in a two-player competitive game (Rock-Paper-Scissors). This manipulation made participants feel more unity with that player and resulted in unity-related activation in the premotor area during action observation. In the following main experiment, the participant witnessed the previously cheered-for or non-cheered-for player succeed in a new solitary game (a stopwatch game). The ventromedial prefrontal cortex (vmPFC) was activated when the cheered-for player succeeded in the game but not when the other player did. Interestingly, this vmPFC activation was functionally connected with premotor activation only during the cheered-for player's success. These results suggest that vicarious reward is processed in the vmPFC-premotor network, which is activated specifically by the success of the other person with whom the individual feels unity and closeness.

  15. GATING CIRCUITS

    Science.gov (United States)

    Merrill, L.C.

    1958-10-14

    Control circuits for vacuum tubes are described, and a binary counter having an improved trigger circuit is reported. The salient feature of the binary counter is the application of the input signal to the cathode of each of two vacuum tubes through separate capacitors and the connection of each cathode to ground through separate diodes. The control of the binary counter is achieved in this manner without special pulse shaping of the input signal. A further advantage of the circuit is the simplicity and minimum nuruber of components required, making its use particularly desirable in computer machines.

  16. Space, matter and topology

    CERN Document Server

    Asorey, Manuel

    2016-01-01

    An old branch of mathematics, Topology, has opened the road to the discovery of new phases of matter. A hidden topology in the energy spectrum is the key for novel conducting/insulating properties of topological matter.

  17. Differential topology

    CERN Document Server

    Margalef-Roig, J

    1992-01-01

    ...there are reasons enough to warrant a coherent treatment of the main body of differential topology in the realm of Banach manifolds, which is at the same time correct and complete. This book fills the gap: whenever possible the manifolds treated are Banach manifolds with corners. Corners add to the complications and the authors have carefully fathomed the validity of all main results at corners. Even in finite dimensions some results at corners are more complete and better thought out here than elsewhere in the literature. The proofs are correct and with all details. I see this book as a reliable monograph of a well-defined subject; the possibility to fall back to it adds to the feeling of security when climbing in the more dangerous realms of infinite dimensional differential geometry. Peter W. Michor

  18. Synthetic Biology: A Unifying View and Review Using Analog Circuits.

    Science.gov (United States)

    Teo, Jonathan J Y; Woo, Sung Sik; Sarpeshkar, Rahul

    2015-08-01

    We review the field of synthetic biology from an analog circuits and analog computation perspective, focusing on circuits that have been built in living cells. This perspective is well suited to pictorially, symbolically, and quantitatively representing the nonlinear, dynamic, and stochastic (noisy) ordinary and partial differential equations that rigorously describe the molecular circuits of synthetic biology. This perspective enables us to construct a canonical analog circuit schematic that helps unify and review the operation of many fundamental circuits that have been built in synthetic biology at the DNA, RNA, protein, and small-molecule levels over nearly two decades. We review 17 circuits in the literature as particular examples of feedforward and feedback analog circuits that arise from special topological cases of the canonical analog circuit schematic. Digital circuit operation of these circuits represents a special case of saturated analog circuit behavior and is automatically incorporated as well. Many issues that have prevented synthetic biology from scaling are naturally represented in analog circuit schematics. Furthermore, the deep similarity between the Boltzmann thermodynamic equations that describe noisy electronic current flow in subthreshold transistors and noisy molecular flux in biochemical reactions has helped map analog circuit motifs in electronics to analog circuit motifs in cells and vice versa via a `cytomorphic' approach. Thus, a body of knowledge in analog electronic circuit design, analysis, simulation, and implementation may also be useful in the robust and efficient design of molecular circuits in synthetic biology, helping it to scale to more complex circuits in the future.

  19. Electronically Tunable Sinusoidal Oscillator Circuit

    Directory of Open Access Journals (Sweden)

    Sudhanshu Maheshwari

    2012-01-01

    Full Text Available This paper presents a novel electronically tunable third-order sinusoidal oscillator synthesized from a simple topology, employing current-mode blocks. The circuit is realized using the active element: Current Controlled Conveyors (CCCIIs and grounded passive components. The new circuit enjoys the advantages of noninteractive electronically tunable frequency of oscillation, use of grounded passive components, and the simultaneous availability of three sinusoidal voltage outputs. Bias current generation scheme is given for the active elements used. The circuit exhibits good high frequency performance. Nonideal and parasitic study has also been carried out. Wide range frequency tuning is shown with the bias current. The proposed theory is verified through extensive PSPICE simulations using 0.25 μm CMOS process parameters.

  20. The topology of geology 2: Topological uncertainty

    Science.gov (United States)

    Thiele, Samuel T.; Jessell, Mark W.; Lindsay, Mark; Wellmann, J. Florian; Pakyuz-Charrier, Evren

    2016-10-01

    Uncertainty is ubiquitous in geology, and efforts to characterise and communicate it are becoming increasingly important. Recent studies have quantified differences between perturbed geological models to gain insight into uncertainty. We build on this approach by quantifying differences in topology, a property that describes geological relationships in a model, introducing the concept of topological uncertainty. Data defining implicit geological models were perturbed to simulate data uncertainties, and the amount of topological variation in the resulting model suite measured to provide probabilistic assessments of specific topological hypotheses, sources of topological uncertainty and the classification of possible model realisations based on their topology. Overall, topology was found to be highly sensitive to small variations in model construction parameters in realistic models, with almost all of the several thousand realisations defining distinct topologies. In particular, uncertainty related to faults and unconformities was found to have profound topological implications. Finally, possible uses of topology as a geodiversity metric and validation filter are discussed, and methods of incorporating topological uncertainty into physical models are suggested.

  1. The topology of geology 1: Topological analysis

    Science.gov (United States)

    Thiele, Samuel T.; Jessell, Mark W.; Lindsay, Mark; Ogarko, Vitaliy; Wellmann, J. Florian; Pakyuz-Charrier, Evren

    2016-10-01

    Topology has been used to characterise and quantify the properties of complex systems in a diverse range of scientific domains. This study explores the concept and applications of topological analysis in geology. We have developed an automatic system for extracting first order 2D topological information from geological maps, and 3D topological information from models built with the Noddy kinematic modelling system, and equivalent analyses should be possible for other implicit modelling systems. A method is presented for describing the spatial and temporal topology of geological models using a set of adjacency relationships that can be expressed as a topology network, thematic adjacency matrix or hive diagram. We define three types of spatial topology (cellular, structural and lithological) that allow us to analyse different aspects of the geology, and then apply them to investigate the geology of the Hamersley Basin, Western Australia.

  2. Motor and premotor cortices in subcortical stroke: proton magnetic resonance spectroscopy measures and arm motor impairment.

    Science.gov (United States)

    Craciunas, Sorin C; Brooks, William M; Nudo, Randolph J; Popescu, Elena A; Choi, In-Young; Lee, Phil; Yeh, Hung-Wen; Savage, Cary R; Cirstea, Carmen M

    2013-06-01

    Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies. We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons. In 20 participants at >6 months postonset of a subcortical ischemic stroke and 16 age- and sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1), dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores were explored. N-Acetylaspartate was lower in M1 (P = .04) and SMA (P = .004) and myo-inositol was higher in M1 (P = .003) and PMd (P = .03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere in controls. N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P = .04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (P = .02, .01, .02, and .02, respectively). Our preliminary results demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes to arm motor impairment.

  3. Mirror Neurons of Ventral Premotor Cortex Are Modulated by Social Cues Provided by Others' Gaze.

    Science.gov (United States)

    Coudé, Gino; Festante, Fabrizia; Cilia, Adriana; Loiacono, Veronica; Bimbi, Marco; Fogassi, Leonardo; Ferrari, Pier Francesco

    2016-03-16

    Mirror neurons (MNs) in the inferior parietal lobule and ventral premotor cortex (PMv) can code the intentions of other individuals using contextual cues. Gaze direction is an important social cue that can be used for understanding the meaning of actions made by other individuals. Here we addressed the issue of whether PMv MNs are influenced by the gaze direction of another individual. We recorded single-unit activity in macaque PMv while the monkey was observing an experimenter performing a grasping action and orienting his gaze either toward (congruent gaze condition) or away (incongruent gaze condition) from a target object. The results showed that one-half of the recorded MNs were modulated by the gaze direction of the human agent. These gaze-modulated neurons were evenly distributed between those preferring a gaze direction congruent with the direction where the grasping action was performed and the others that preferred an incongruent gaze. Whereas the presence of congruent responses is in line with the usual coupling of hand and gaze in both executed and observed actions, the incongruent responses can be explained by the long exposure of the monkeys to this condition. Our results reveal that the representation of observed actions in PMv is influenced by contextual information not only extracted from physical cues, but also from cues endowed with biological or social value. In this study, we present the first evidence showing that social cues modulate MNs in the monkey ventral premotor cortex. These data suggest that there is an integrated representation of other's hand actions and gaze direction at the single neuron level in the ventral premotor cortex, and support the hypothesis of a functional role of MNs in decoding actions and understanding motor intentions. Copyright © 2016 the authors 0270-6474/16/363145-12$15.00/0.

  4. Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex.

    Science.gov (United States)

    Wheaton, Kylie J; Thompson, James C; Syngeniotis, Ari; Abbott, David F; Puce, Aina

    2004-05-01

    Activation of premotor and temporoparietal cortex occurs when we observe others movements, particularly relating to objects. Viewing the motion of different body parts without the context of an object has not been systematically evaluated. During a 3T fMRI study, 12 healthy subjects viewed human face, hand, and leg motion, which was not directed at or did not involve an object. Activation was identified relative to static images of the same human face, hand, and leg in both individual subject and group average data. Four clear activation foci emerged: (1) right MT/V5 activated to all forms of viewed motion; (2) right STS activated to face and leg motion; (3) ventral premotor cortex activated to face, hand, and leg motion in the right hemisphere and to leg motion in the left hemisphere; and (4) anterior intraparietal cortex (aIP) was active bilaterally to viewing hand motion and in the right hemisphere leg motion. In addition, in the group data, a somatotopic activation pattern for viewing face, hand, and leg motion occurred in right ventral premotor cortex. Activation patterns in STS and aIP were more complex--typically activation foci to viewing two types of human motion showed some overlap. Activation in individual subjects was similar; however, activation to hand motion also occurred in the STS with a variable location across subjects--explaining the lack of a clear activation focus in the group data. The data indicate that there are selective responses to viewing motion of different body parts in the human brain that are independent of object or tool use.

  5. Optical image encryption topology.

    Science.gov (United States)

    Yong-Liang, Xiao; Xin, Zhou; Qiong-Hua, Wang; Sheng, Yuan; Yao-Yao, Chen

    2009-10-15

    Optical image encryption topology is proposed based on the principle of random-phase encoding. Various encryption topological units, involving peer-to-peer, ring, star, and tree topologies, can be realized by an optical 6f system. These topological units can be interconnected to constitute an optical image encryption network. The encryption and decryption can be performed in both digital and optical methods.

  6. The topology of architecture

    DEFF Research Database (Denmark)

    Marcussen, Lars

    2003-01-01

    Rummets topologi, Historiens topologi: betragtninger om menneskets orientering til rum - fra hulen over beherskelse af flere akser til det flydende rum.......Rummets topologi, Historiens topologi: betragtninger om menneskets orientering til rum - fra hulen over beherskelse af flere akser til det flydende rum....

  7. Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele.

    Science.gov (United States)

    Anders, Silke; Sack, Benjamin; Pohl, Anna; Münte, Thomas; Pramstaller, Peter; Klein, Christine; Binkofski, Ferdinand

    2012-04-01

    Patients with Parkinson's disease suffer from significant motor impairments and accompanying cognitive and affective dysfunction due to progressive disturbances of basal ganglia-cortical gating loops. Parkinson's disease has a long presymptomatic stage, which indicates a substantial capacity of the human brain to compensate for dopaminergic nerve degeneration before clinical manifestation of the disease. Neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant Parkin or PINK1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. However, it is currently unknown whether similar compensatory mechanisms are effective in non-motor basal ganglia-cortical gating loops. Here, we ask whether asymptomatic Parkin mutation carriers show altered patterns of brain activity during processing of facial gestures, and whether this might compensate for latent facial emotion recognition deficits. Current theories in social neuroscience assume that execution and perception of facial gestures are linked by a special class of visuomotor neurons ('mirror neurons') in the ventrolateral premotor cortex/pars opercularis of the inferior frontal gyrus (Brodmann area 44/6). We hypothesized that asymptomatic Parkin mutation carriers would show increased activity in this area during processing of affective facial gestures, replicating the compensatory motor effects that have previously been observed in these individuals. Additionally, Parkin mutation carriers might show altered activity in other basal ganglia-cortical gating loops. Eight asymptomatic heterozygous Parkin mutation carriers and eight matched controls underwent functional magnetic resonance imaging and a subsequent facial emotion recognition task. As predicted, Parkin mutation carriers showed significantly stronger activity in

  8. Topological vector spaces

    CERN Document Server

    Narici, Lawrence

    2011-01-01

    BackgroundTopology Valuation Theory Algebra Linear Functionals Hyperplanes Measure Theory Normed SpacesCommutative Topological GroupsElementary ConsiderationsSeparation and Compactness Bases at 0 for Group Topologies Subgroups and Products Quotients S-Topologies Metrizability CompletenessCompleteness Function Groups Total BoundednessCompactness and Total Boundedness Uniform Continuity Extension of Uniformly Continuous Maps CompletionTopological Vector SpacesAbsorbent and Balanced Sets Convexity-AlgebraicBasic PropertiesConvexity-Topological Generating Vector Topologies A Non-Locally Convex Spa

  9. Topological superconductors: a review.

    Science.gov (United States)

    Sato, Masatoshi; Ando, Yoichi

    2017-04-03

    This review elaborates pedagogically on the fundamental concept, basic theory, expected properties, and materials realizations of topological superconductors. The relation between topological superconductivity and Majorana fermions are explained, and the difference between dispersive Majorana fermions and a localized Majorana zero mode is emphasized. A variety of routes to topological superconductivity are explained with an emphasis on the roles of spin-orbit coupling. Present experimental situations and possible signatures of topological superconductivity are summarized with an emphasis on intrinsic topological superconductors.

  10. Strongly Correlated Topological Insulators

    Science.gov (United States)

    2016-02-03

    Research Triangle Park , NC 27709-2211 Condensed Matter, Topological Phases of Matter REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S...Strongly Correlated Topological Insulators In the past year, the grant was used for work in the field of topological phases, with emphasis on finding...surface of topological insulators. In the past 3 years, we have started a new direction, that of fractional topological insulators. These are materials

  11. Relative Smooth Topological Spaces

    Directory of Open Access Journals (Sweden)

    B. Ghazanfari

    2009-01-01

    Full Text Available In 1992, Ramadan introduced the concept of a smooth topological space and relativeness between smooth topological space and fuzzy topological space in Chang's (1968 view points. In this paper we give a new definition of smooth topological space. This definition can be considered as a generalization of the smooth topological space which was given by Ramadan. Some general properties such as relative smooth continuity and relative smooth compactness are studied.

  12. State-Space Formulation for Circuit Analysis

    Science.gov (United States)

    Martinez-Marin, T.

    2010-01-01

    This paper presents a new state-space approach for temporal analysis of electrical circuits. The method systematically obtains the state-space formulation of nondegenerate linear networks without using concepts of topology. It employs nodal/mesh systematic analysis to reduce the number of undesired variables. This approach helps students to…

  13. Secondary Side CMOS Feedback Control Integrated Circuit

    Science.gov (United States)

    1990-06-01

    Temperature ( Celc ~us) Figure 5.1: Experimental Temperature Dependence cf Untrimmed Bandgap Circuit 104 1. I I ’ - ’ 0 0.9 . -0-0 Ouput Voit -ge ---.o M...Schlecht and L.F. Casey, "Comparison of the Square-Wave and Quasi- Resonant Topologies," IEEE PESC Record, 1987, pp. 124-134. 132

  14. Controllable circuit

    DEFF Research Database (Denmark)

    2010-01-01

    A switch-mode power circuit comprises a controllable element and a control unit. The controllable element is configured to control a current in response to a control signal supplied to the controllable element. The control unit is connected to the controllable element and provides the control...

  15. Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition

    DEFF Research Database (Denmark)

    Hartwigsen, Gesa; Saur, Dorothee; Price, Cathy J

    2013-01-01

    were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word...... repetition. The optimal model was identified with Bayesian model selection and reflected a network with driving input to pre-SMA and an increase in facilitatory drive from pre-SMA to PMd during repetition of pseudowords. The task-specific increase in effective connectivity from pre-SMA to left PMd suggests...... that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection....

  16. Engineering topological materials in microwave cavity arrays

    CERN Document Server

    Anderson, Brandon M; Owens, Clai; Schuster, David I; Simon, Jonathan

    2016-01-01

    We present a scalable architecture for the exploration of interacting topological phases of photons in arrays of microwave cavities, using established techniques from cavity and circuit quantum electrodynamics. A time-reversal symmetry breaking (non-reciprocal) flux is induced by coupling the microwave cavities to ferrites, allowing for the production of a variety of topological band structures including the $\\alpha=1/4$ Hofstadter model. Effective photon-photon interactions are included by coupling the cavities to superconducting qubits, and are sufficient to produce a $\

  17. Processing of Own Hand Visual Feedback during Object Grasping in Ventral Premotor Mirror Neurons.

    Science.gov (United States)

    Maranesi, Monica; Livi, Alessandro; Bonini, Luca

    2015-08-26

    Mirror neurons (MNs) discharge during action execution as well as during observation of others' actions. Our own actions are those that we have the opportunity to observe more frequently, but no study thus far to our knowledge has addressed the issue of whether, and to what extent, MNs can code own hand visual feedback (HVF) during object grasping. Here, we show that MNs of the ventral premotor area F5 of macaque monkeys are particularly sensitive to HVF relative to non-MNs simultaneously recorded in the same penetrations. Importantly, the HVF effect is more evident on MN activity during hand-object interaction than during the hand-shaping phase. Furthermore, the increase of MN activity induced by HVF and others' actions observed from a subjective perspective were positively correlated. These findings indicate that at least part of ventral premotor MNs can process the visual information coming from own hand interacting with objects, likely playing a role in self-action monitoring. We show that mirror neurons (MNs) of area F5 of the macaque, in addition to encoding others' observed actions, are particularly sensitive, relative to simultaneously recorded non-MNs, to the sight of the monkey's own hand during object grasping, likely playing a role in self-action monitoring. Copyright © 2015 the authors 0270-6474/15/3511824-06$15.00/0.

  18. Sequences of abstract nonbiological stimuli share ventral premotor cortex with action observation and imagery.

    Science.gov (United States)

    Schubotz, Ricarda I; von Cramon, D Yves

    2004-06-16

    Activation triggered by either observed or imagined actions suggests that the ventral premotor cortex (PMv) provides an action vocabulary that allows us to detect and anticipate basically invariant perceptual states in observed actions. In the present study, we tested the hypothesis that the same PMv region is also recruited by nonbiological (abstract) stimulus sequences as long as the temporal order of stimuli has to be processed. Using functional magnetic resonance imaging, we instructed participants to assess expected outcomes in observed actions [external biological cues (EB)], motor imagery [internal biological cues (IB)], or geometrical figure sequences [external nonbiological cues (EN)]. As hypothesized, we found that each condition elicited significant activation within PMv [left hemisphere, Brodman Area (BA) 6], in contrast to a sequential target detection control task. In addition, cue-specific activations were identified in areas that were only engaged for biologically (action) cued (EB, IB) and nonbiologically cued (EN) tasks. Biologically cued tasks elicited activations within inferior frontal gyri adjacent to PMv (BA 44/45), in the frontomedian wall, the extrastriate body area, posterior superior temporal sulci, somatosensory cortices, and the amygdala-hippocampal-area, whereas the nonbiologically cued task engaged presupplementary motor area, middle frontal gyri, intraparietal sulci, and caudate nuclei of the basal ganglia. In sum, findings point to a basic premotor contribution to the representation or processing of sequentially structured events, supplemented by different sets of areas in the context of either biological or nonbiological cues.

  19. MEG premotor abnormalities in children with Asperger's syndrome: determinants of social behavior?

    Science.gov (United States)

    Hauswald, Anne; Weisz, Nathan; Bentin, Shlomo; Kissler, Johanna

    2013-07-01

    Children with Asperger's syndrome show deficits in social functioning while their intellectual and language development is intact suggesting a specific dysfunction in mechanisms mediating social cognition. An action observation/execution matching system might be one such mechanism. Recent studies indeed showed that electrophysiological modulation of the "Mu-rhythm" in the 10-12Hz range is weaker when individuals with Asperger's syndrome observe actions performed by others compared to controls. However, electrophysiological studies typically fall short in revealing the neural generators of this activity. To fill this gap we assessed magnetoencephalographic Mu-modulations in Asperger's and typically developed children, while observing grasping movements. Mu-power increased at frontal and central sensors during movement observation. This modulation was stronger in typical than in Asperger children. Source localization revealed stronger sources in premotor cortex, the intraparietal lobule (IPL) and the mid-occipito-temporal gyrus (MOTG) and weaker sources in prefrontal cortex in typical participants compared to Asperger. Activity in premotor regions, IPL and MOTG correlated positively with social competence, whereas prefrontal Mu-sources correlated negatively with social competence. No correlation with intellectual ability was found at any of these sites. These findings localize abnormal Mu-activity in the brain of Asperger children providing evidence which associates motor-system abnormalities with social-function deficits.

  20. Beta activity in the premotor cortex is increased during stabilized as compared to normal walking

    Directory of Open Access Journals (Sweden)

    Sjoerd M. Bruijn

    2015-10-01

    Full Text Available Walking on two legs is inherently unstable. Still, we humans perform remarkable well at it, mostly without falling. To gain more understanding of the role of the brain in controlling gait stability we measured brain activity using electro-encephalography (EEG during stabilized and normal walking.Subjects walked on a treadmill in two conditions, each lasting 10 minutes; normal, and while being laterally stabilized by elastic cords. Kinematics of trunk and feet, electro-myography (EMG of neck muscles, as well as 64-channel EEG were recorded. To assess gait stability the local divergence exponent, step width, and trunk range of motion were calculated from the kinematic data. We used independent component analysis to remove movement, EMG, and eyeblink artifacts from the EEG, after which dynamic imaging of coherent sources beamformers were determined to identify cortical sources that showed a significant difference between conditions. Stabilized walking led to a significant increase in gait stability, i.e. lower local divergence exponents. Beamforming analysis of the beta band activity revealed significant sources in bilateral pre-motor cortices. Projection of sensor data on these sources showed a significant difference only in the left premotor area, with higher beta power during stabilized walking, specifically around push-off, although only significant around contralateral push-off. It appears that even during steady gait the cortex is involved in the control of stability.

  1. Topological effects on the magnetoconductivity in topological insulators

    Science.gov (United States)

    Sacksteder, Vincent E.; Arnardottir, Kristin Bjorg; Kettemann, Stefan; Shelykh, Ivan A.

    2014-12-01

    Three-dimensional strong topological insulators (TIs) guarantee the existence of a two-dimensional (2-D) conducting surface state which completely covers the surface of the TI. The TI surface state necessarily wraps around the TI's top, bottom, and two sidewalls, and is therefore topologically distinct from ordinary 2-D electron gases (2-DEGs) which are planar. This has several consequences for the magnetoconductivity Δ σ , a frequently studied measure of weak antilocalization which is sensitive to the quantum coherence time τϕ and to temperature. We show that conduction on the TI sidewalls systematically reduces Δ σ , multiplying it by a factor which is always less than one and decreases in thicker samples. In addition, we present both an analytical formula and numerical results for the tilted-field magnetoconductivity which has been measured in several experiments. Lastly, we predict that as the temperature is reduced Δ σ will enter a wrapped regime where it is sensitive to diffusion processes which make one or more circuits around the TI. In this wrapped regime the magnetoconductivity's dependence on temperature, typically 1 /T2 in 2-DEGs, disappears. We present numerical and analytical predictions for the wrapped regime at both small and large field strengths. The wrapped regime and topological signatures discussed here should be visible in the same samples and at the same temperatures where the Altshuler-Aronov-Spivak (AAS) effect has already been observed, when the measurements are repeated with the magnetic field pointed perpendicularly to the TI's top face.

  2. Chiral Hyperbolic Metamaterial as A Robust Photonic Topological Insulator

    CERN Document Server

    Gao, Wenlong; Yang, Biao; Liu, Fu; Fang, Fengzhou; Li, Jensen; Zhang, Shuang

    2014-01-01

    Topological insulators represent a new phase of matter which remain insulating for bulk electron transport while supporting protected one-way edge states. Recently it has been shown that the concept of topological order can also be transferred to photonic systems. Thus far however, photonic topological insulators have been realized almost exclusively in periodic structures where the specific connection between lattice symmetry and the band structure plays a critical role. Here we demonstrate robust photonic topological order in a homogenous medium described by only a few effective electromagnetic parameters, and not requiring the presence of an external magnetic field. By combining hyperbolicity and chirality, we show that a topologically nontrivial gap appears between the equi-frequency surfaces which support one-way edge states. The effective medium approach towards topological insulation paves the way for highly compact one-way transportation of electromagnetic waves in integrated photonic circuits.

  3. Static power dissipation in adder circuits: the UDSM domain

    Science.gov (United States)

    Cayouette, Steve; Al-Khalili, Dhamin

    2009-05-01

    This paper presents adder circuits of various architectures aimed at reducing static power dissipation. Circuit topologies for basic building blocks were evaluated for fabrication technologies of 65nm down to 32nm, and simulation results are presented. This work has lead to the development of various low power adder circuits and provides comparative analysis leading to the recommendation that a variable size block carry select adder is the best performer, taking into consideration both static and dynamic power dissipation.

  4. Quasi-Linear Circuit

    Science.gov (United States)

    Bradley, William; Bird, Ross; Eldred, Dennis; Zook, Jon; Knowles, Gareth

    2013-01-01

    This work involved developing spacequalifiable switch mode DC/DC power supplies that improve performance with fewer components, and result in elimination of digital components and reduction in magnetics. This design is for missions where systems may be operating under extreme conditions, especially at elevated temperature levels from 200 to 300 degC. Prior art for radiation-tolerant DC/DC converters has been accomplished utilizing classical magnetic-based switch mode converter topologies; however, this requires specific shielding and component de-rating to meet the high-reliability specifications. It requires complex measurement and feedback components, and will not enable automatic re-optimization for larger changes in voltage supply or electrical loading condition. The innovation is a switch mode DC/DC power supply that eliminates the need for processors and most magnetics. It can provide a well-regulated voltage supply with a gain of 1:100 step-up to 8:1 step down, tolerating an up to 30% fluctuation of the voltage supply parameters. The circuit incorporates a ceramic core transformer in a manner that enables it to provide a well-regulated voltage output without use of any processor components or magnetic transformers. The circuit adjusts its internal parameters to re-optimize its performance for changes in supply voltage, environmental conditions, or electrical loading at the output

  5. Research of Driving Circuit in Coaxial Induction Coilgun

    Directory of Open Access Journals (Sweden)

    Yadong Zhang

    2013-09-01

    Full Text Available Power supply is crucial equipment in coaxial induction coil launcher.Configuration of the driving circuit influences the efficiency of the coil launcher directly.This paper gives a detailed analysis of the properties of the driving circuit construction based on the capacitor source. Three topologies of the driving circuit are compared including oscillation circuit, crowbar circuit and half-wave circuit. It is proved that which circuit has the better efficiency depends on the detailed parameters of the experiment, especially the crowbar resistance. Crowbar resistor regulates not only efficiency of the system, but also temperature rise of the coil. Electromagnetic force (EMF applied on the armature will be another question which influences service condition of the driving circuits. Oscillation circuit and crowbar circuit should apply to the asynchronous induction coil launcher and synchronous induction coil launcher, respectively. Half-wave circuit is seldom used in the experiment. Although efficiency of the half-wave circuit is very high, the speed of the armature is low. A simple independent half-wave circuit is suggested in this paper. Generally speaking, the comprehensive property of crowbar circuit is the most practical in the three typical circuits. Conclusions of the paper could provide guidelines for practice.

  6. Topological inverse semigroups

    Institute of Scientific and Technical Information of China (English)

    ZHU Yongwen

    2004-01-01

    That the projective limit of any projective system of compact inverse semigroups is also a compact inverse semigroup,the injective limit of any injective system of inverse semigroups is also an inverse semigroup, and that a compact inverse semigroup is topologically isomorphic to a strict projective limit of compact metric inverse semigroups are proved. It is also demonstrated that Horn (S,T) is a topological inverse semigroup provided that S or T is a topological inverse semigroup with some other conditions. Being proved by means of the combination of topological semigroup theory with inverse semigroup theory,all these results generalize the corresponding ones related to topological semigroups or topological groups.

  7. Topological insulators: Engineered heterostructures

    Science.gov (United States)

    Hesjedal, Thorsten; Chen, Yulin

    2017-01-01

    The combination of topological properties and magnetic order can lead to new quantum states and exotic physical phenomena. In particular, the coupling between topological insulators and antiferromagnets enables magnetic and electronic structural engineering.

  8. Book Review: Computational Topology

    DEFF Research Database (Denmark)

    Raussen, Martin

    2011-01-01

    Computational Topology by Herbert Edelsbrunner and John L. Harer. American Matheamtical Society, 2010 - ISBN 978-0-8218-4925-5......Computational Topology by Herbert Edelsbrunner and John L. Harer. American Matheamtical Society, 2010 - ISBN 978-0-8218-4925-5...

  9. Analog and VLSI circuits

    CERN Document Server

    Chen, Wai-Kai

    2009-01-01

    Featuring hundreds of illustrations and references, this book provides the information on analog and VLSI circuits. It focuses on analog integrated circuits, presenting the knowledge on monolithic device models, analog circuit cells, high performance analog circuits, RF communication circuits, and PLL circuits.

  10. Colloquium: Topological band theory

    Science.gov (United States)

    Bansil, A.; Lin, Hsin; Das, Tanmoy

    2016-04-01

    The first-principles band theory paradigm has been a key player not only in the process of discovering new classes of topologically interesting materials, but also for identifying salient characteristics of topological states, enabling direct and sharpened confrontation between theory and experiment. This review begins by discussing underpinnings of the topological band theory, which involve a layer of analysis and interpretation for assessing topological properties of band structures beyond the standard band theory construct. Methods for evaluating topological invariants are delineated, including crystals without inversion symmetry and interacting systems. The extent to which theoretically predicted properties and protections of topological states have been verified experimentally is discussed, including work on topological crystalline insulators, disorder and interaction driven topological insulators (TIs), topological superconductors, Weyl semimetal phases, and topological phase transitions. Successful strategies for new materials discovery process are outlined. A comprehensive survey of currently predicted 2D and 3D topological materials is provided. This includes binary, ternary, and quaternary compounds, transition metal and f -electron materials, Weyl and 3D Dirac semimetals, complex oxides, organometallics, skutterudites, and antiperovskites. Also included is the emerging area of 2D atomically thin films beyond graphene of various elements and their alloys, functional thin films, multilayer systems, and ultrathin films of 3D TIs, all of which hold exciting promise of wide-ranging applications. This Colloquium concludes by giving a perspective on research directions where further work will broadly benefit the topological materials field.

  11. On generalized topological spaces

    OpenAIRE

    Piȩkosz, Artur

    2009-01-01

    In this paper a systematic study of the category GTS of generalized topological spaces (in the sense of H. Delfs and M. Knebusch) and their strictly continuous mappings begins. Some completeness and cocompleteness results are achieved. Generalized topological spaces help to reconstruct the important elements of the theory of locally definable and weakly definable spaces in the wide context of weakly topological structures.

  12. Free Boolean Topological Groups

    Directory of Open Access Journals (Sweden)

    Ol’ga Sipacheva

    2015-11-01

    Full Text Available Known and new results on free Boolean topological groups are collected. An account of the properties that these groups share with free or free Abelian topological groups and properties specific to free Boolean groups is given. Special emphasis is placed on the application of set-theoretic methods to the study of Boolean topological groups.

  13. Symmetric Bombay topology

    Directory of Open Access Journals (Sweden)

    Giuseppe Di Maio

    2008-04-01

    Full Text Available The subject of hyperspace topologies on closed or closed and compact subsets of a topological space X began in the early part of the last century with the discoveries of Hausdorff metric and Vietoris hit-and-miss topology. In course of time, several hyperspace topologies were discovered either for solving some problems in Applied or Pure Mathematics or as natural generalizations of the existing ones. Each hyperspace topology can be split into a lower and an upper part. In the upper part the original set inclusion of Vietoris was generalized to proximal set inclusion. Then the topologization of the Wijsman topology led to the upper Bombay topology which involves two proximities. In all these developments the lower topology, involving intersection of finitely many open sets, was generalized to locally finite families but intersection was left unchanged. Recently the authors studied symmetric proximal topology in which proximity was used for the first time in the lower part replacing intersection with its generalization: nearness. In this paper we use two proximities also in the lower part and we obtain the lower Bombay hypertopology. Consequently, a new hypertopology arises in a natural way: the symmetric Bombay topology which is the join of a lower and an upper Bombay topology.

  14. Premotor spinal network with balanced excitation and inhibition during motor patterns has high resilience to structural division

    DEFF Research Database (Denmark)

    Petersen, Peter C; Vestergaard, Mikkel; Reveles Jensen, Kristian

    2014-01-01

    Direct measurements of synaptic inhibition (I) and excitation (E) to spinal motoneurons can provide an important insight into the organization of premotor networks. Such measurements of flexor motoneurons participating in motor patterns in turtles have recently demonstrated strong concurrent E an...

  15. Different distal-proximal movement balances in right- and left-hand writing may hint at differential premotor cortex involvement

    NARCIS (Netherlands)

    Potgieser, A. R. E.; de Jong, B. M.

    2011-01-01

    Right-handed people generally write with their right hand. Language expressed in script is thus performed with the hand also preferred for skilled motor tasks. This may suggest an efficient functional interaction between the language area of Broca and the adjacent ventral premotor cortex (PMv) in th

  16. Different distal-proximal movement balances in right- and left-hand writing may hint at differential premotor cortex involvement

    NARCIS (Netherlands)

    Potgieser, A. R. E.; de Jong, B. M.

    2011-01-01

    Right-handed people generally write with their right hand. Language expressed in script is thus performed with the hand also preferred for skilled motor tasks. This may suggest an efficient functional interaction between the language area of Broca and the adjacent ventral premotor cortex (PMv) in th

  17. Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actions

    DEFF Research Database (Denmark)

    Ward, Nick S; Bestmann, Sven; Hartwigsen, Gesa

    2010-01-01

    responses in invalidly cued trials. After real rTMS, task-related activity of the stimulated left rPMd showed increased task-related coupling with activity in ipsilateral SMG and the adjacent anterior intraparietal area (AIP). Individuals who showed a stronger increase in left-hemispheric premotor-parietal...

  18. Area, Delay and Power Comparison of Adder Topologies

    OpenAIRE

    R.Uma; Vidya Vijayan; M. Mohanapriya; Sharon Paul

    2012-01-01

    Adders form an almost obligatory component of every contemporary integrated circuit. The prerequisite of the adder is that it is primarily fast and secondarily efficient in terms of power consumption and chip area. This paper presents the pertinent choice for selecting the adder topology with the tradeoff between delay, power consumption and area. The adder topology used in this work are ripple carry adder, carry lookahead adder, carry skip adder, carry select adder, carry increment adder, ca...

  19. Area, Delay and Power Comparison of Adder Topologies

    OpenAIRE

    R.UMA,Vidya Vijayan; M. Mohanapriya; Sharon Paul

    2012-01-01

    Adders form an almost obligatory component of every contemporary integrated circuit. The prerequisite of the adder is that it is primarily fast and secondarily efficient in terms of power consumption and chip area. This paper presents the pertinent choice for selecting the adder topology with the trade off between delay, power consumption and area. The adder topology used in this work are ripple carry adder, carry look ahead adder, carry skip adder, carry select adder, carry increment adder, ...

  20. Dynamic Control of Response Criterion in Premotor Cortex during Perceptual Detection under Temporal Uncertainty.

    Science.gov (United States)

    Carnevale, Federico; de Lafuente, Victor; Romo, Ranulfo; Barak, Omri; Parga, Néstor

    2015-05-20

    Under uncertainty, the brain uses previous knowledge to transform sensory inputs into the percepts on which decisions are based. When the uncertainty lies in the timing of sensory evidence, however, the mechanism underlying the use of previously acquired temporal information remains unknown. We study this issue in monkeys performing a detection task with variable stimulation times. We use the neural correlates of false alarms to infer the subject's response criterion and find that it modulates over the course of a trial. Analysis of premotor cortex activity shows that this modulation is represented by the dynamics of population responses. A trained recurrent network model reproduces the experimental findings and demonstrates a neural mechanism to benefit from temporal expectations in perceptual detection. Previous knowledge about the probability of stimulation over time can be intrinsically encoded in the neural population dynamics, allowing a flexible control of the response criterion over time.

  1. Decision-making in the ventral premotor cortex harbinger of action

    Directory of Open Access Journals (Sweden)

    José L. ePardo-Vázquez

    2011-09-01

    Full Text Available Although the premotor cortex (PM was once viewed as the substrate of pure motor functions, soon it was realized that it was involved in higher brain functions. By this it is meant that the PM cortex functions would better be explained as motor set, preparation for limb movement or sensory guidance of movement rather than solely by a fixed link to motor performance. These findings, together with a better knowledge of the PM cortex histology and hodology in human and non-human primates prompted quantitative studies of this area combining behavioral tasks with electrophysiological recordings. In addition, the exploration of the PM cortex neurons with qualitative methods also suggested its participation in higher functions. Behavioral choices frequently depend on temporal cues, which together with knowledge of previous outcomes and expectancies are combined to decide and choose a behavioral action. In decision-making the knowledge about the consequences of decisions, either correct or incorrect, is fundamental because they can be used to adapt future behavior. The neuronal correlates of a decision process have been described in several cortical areas of primates. Among them, there is evidence that the monkey ventral premotor cortex (PMv, an anatomical and physiological well-differentiated area of the PM cortex, supports both perceptual decisions and performance monitoring. Here we review the evidence that the steps in a decision making process are encoded in the firing rate of the PMv neurons. This provides compelling evidence suggesting that the PMv is involved in the use of recent and long-term sensory memory to decide, execute and evaluate the outcomes of the subjects’ choices.

  2. Optogenetic Investigation of Arousal Circuits.

    Science.gov (United States)

    Tyree, Susan M; de Lecea, Luis

    2017-08-15

    Modulation between sleep and wake states is controlled by a number of heterogeneous neuron populations. Due to the topological proximity and genetic co-localization of the neurons underlying sleep-wake state modulation optogenetic methods offer a significant improvement in the ability to benefit from both the precision of genetic targeting and millisecond temporal control. Beginning with an overview of the neuron populations mediating arousal, this review outlines the progress that has been made in the investigation of arousal circuits since the incorporation of optogenetic techniques and the first in vivo application of optogenetic stimulation in hypocretin neurons in the lateral hypothalamus. This overview is followed by a discussion of the future progress that can be made by incorporating more recent technological developments into the research of neural circuits.

  3. Circuit Connectors

    Science.gov (United States)

    1979-01-01

    The U-shaped wire devices in the upper photo are Digi-Klipsm; aids to compact packaging of electrical and electronic devices. They serve as connectors linking the circuitry of one circuit board with another in multi-board systems. Digi-Klips were originally developed for Goddard Space Flight Center to meet a need for lightweight, reliable connectors to replace hand-wired connections formerly used in spacecraft. They are made of beryllium copper wire, noted for its excellent conductivity and its spring-like properties, which assure solid electrical contact over a long period of time.

  4. LOGIC CIRCUIT

    Science.gov (United States)

    Strong, G.H.; Faught, M.L.

    1963-12-24

    A device for safety rod counting in a nuclear reactor is described. A Wheatstone bridge circuit is adapted to prevent de-energizing the hopper coils of a ball backup system if safety rods, sufficient in total control effect, properly enter the reactor core to effect shut down. A plurality of resistances form one arm of the bridge, each resistance being associated with a particular safety rod and weighted in value according to the control effect of the particular safety rod. Switching means are used to switch each of the resistances in and out of the bridge circuit responsive to the presence of a particular safety rod in its effective position in the reactor core and responsive to the attainment of a predetermined velocity by a particular safety rod enroute to its effective position. The bridge is unbalanced in one direction during normal reactor operation prior to the generation of a scram signal and the switching means and resistances are adapted to unbalance the bridge in the opposite direction if the safety rods produce a predetermined amount of control effect in response to the scram signal. The bridge unbalance reversal is then utilized to prevent the actuation of the ball backup system, or, conversely, a failure of the safety rods to produce the predetermined effect produces no unbalance reversal and the ball backup system is actuated. (AEC)

  5. Triple Point Topological Metals

    Directory of Open Access Journals (Sweden)

    Ziming Zhu

    2016-07-01

    Full Text Available Topologically protected fermionic quasiparticles appear in metals, where band degeneracies occur at the Fermi level, dictated by the band structure topology. While in some metals these quasiparticles are direct analogues of elementary fermionic particles of the relativistic quantum field theory, other metals can have symmetries that give rise to quasiparticles, fundamentally different from those known in high-energy physics. Here, we report on a new type of topological quasiparticles—triple point fermions—realized in metals with symmorphic crystal structure, which host crossings of three bands in the vicinity of the Fermi level protected by point group symmetries. We find two topologically different types of triple point fermions, both distinct from any other topological quasiparticles reported to date. We provide examples of existing materials that host triple point fermions of both types and discuss a variety of physical phenomena associated with these quasiparticles, such as the occurrence of topological surface Fermi arcs, transport anomalies, and topological Lifshitz transitions.

  6. Real Topological Cyclic Homology

    DEFF Research Database (Denmark)

    Høgenhaven, Amalie

    The main topics of this thesis are real topological Hochschild homology and real topological cyclic homology. If a ring or a ring spectrum is equipped with an anti-involution, then it induces additional structure on the topological Hochschild homology spectrum. The group O(2) acts on the spectrum......, where O(2) is the semi-direct product of T, the multiplicative group of complex number of modulus 1, by the group G=Gal(C/R). We refer to this O(2)-spectrum as the real topological Hochschild homology. This generalization leads to a G-equivariant version of topological cyclic homology, which we call...... real topological cyclic homology. The first part of the thesis computes the G-equivariant homotopy type of the real topological cyclic homology of spherical group rings at a prime p with anti-involution induced by taking inverses in the group. The second part of the thesis investigates the derived G...

  7. Collective of mechatronics circuit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-02-15

    This book is composed of three parts, which deals with mechatronics system about sensor, circuit and motor. The contents of the first part are photo sensor of collector for output, locating detection circuit with photo interrupts, photo sensor circuit with CdS cell and lamp, interface circuit with logic and LED and temperature sensor circuit. The second part deals with oscillation circuit with crystal, C-R oscillation circuit, F-V converter, timer circuit, stability power circuit, DC amp and DC-DC converter. The last part is comprised of bridge server circuit, deformation bridge server, controlling circuit of DC motor, controlling circuit with IC for PLL and driver circuit of stepping motor and driver circuit of Brushless.

  8. Nonreciprocity and one-way topological transitions in hyperbolic metamaterials

    Science.gov (United States)

    Leviyev, A.; Stein, B.; Christofi, A.; Galfsky, T.; Krishnamoorthy, H.; Kuskovsky, I. L.; Menon, V.; Khanikaev, A. B.

    2017-07-01

    Control of the electromagnetic waves in nano-scale structured materials is crucial to the development of next generation photonic circuits and devices. In this context, hyperbolic metamaterials, where elliptical isofrequency surfaces are morphed into surfaces with exotic hyperbolic topologies when the structure parameters are tuned, have shown unprecedented control over light propagation and interaction. Here we show that such topological transitions can be even more unusual when the hyperbolic metamaterial is endowed with nonreciprocity. Judicious design of metamaterials with reduced spatial symmetries, together with the breaking of time-reversal symmetry through magnetization, is shown to result in nonreciprocal dispersion and one-way topological phase transitions in hyperbolic metamaterials.

  9. A review of module inverter topologies suitable for photovoltaic system

    DEFF Research Database (Denmark)

    Variath, Reshmi C; Andersen, Michael A. E.; Nielsen, Ole Neis

    2010-01-01

    This paper evaluates eight module inverter topologies and provides an overview of the merits and demerits of each on the basis of circuit level Pspice simulation. The complete system is modeled in Pspice and the model is made as realistic as possible by including the parasitic elements. Only...... the output stage is varied for different topologies keeping the system model unaltered with the same control system and degree of demodulation so as to differentiate the variation of efficiency of these topologies. The purpose of the analysis is to determine which of this topology would be a best fit...... for the system and what are the compromises to be made (if any) to select one of these topologies as the output stage in the PV system....

  10. An Efficiency Improved Active Power Decoupling Circuit with Minimized Implementation Cost

    DEFF Research Database (Denmark)

    Tang, Yi; Blaabjerg, Frede

    2014-01-01

    Active power decoupling techniques are promising solutions for capacitance reduction in single-phase AC/DC or DC/AC systems. This paper proposes a novel circuit topology which can realize the power decoupling function without adding additional active switches into the circuit. Also, the proposed ...... circuit is discussed, and both simulation and experimental results are presented to show the effectiveness of the proposed circuit concept....

  11. Commutation circuit for an HVDC circuit breaker

    Science.gov (United States)

    Premerlani, William J.

    1981-01-01

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components.

  12. A new high-efficiency single-phase transformerless PV inverter topology

    DEFF Research Database (Denmark)

    Kerekes, Tamas; Teodorescu, Remus; Rodriguez, Pedro;

    2011-01-01

    There is a strong trend in the photovoltaic (PV) inverter technology to use transformerless topologies in order to acquire higher efficiencies combining with very low ground leakage current. In this paper a new topology, based on the H-Bridge with a new AC bypass circuit consisting in a diode rec...

  13. Electronic interconnects and devices with topological surface states and methods for fabricating same

    Energy Technology Data Exchange (ETDEWEB)

    Yazdani, Ali; Ong, N. Phuan; Cava, Robert J.

    2017-04-04

    An interconnect is disclosed with enhanced immunity of electrical conductivity to defects. The interconnect includes a material with charge carriers having topological surface states. Also disclosed is a method for fabricating such interconnects. Also disclosed is an integrated circuit including such interconnects. Also disclosed is a gated electronic device including a material with charge carriers having topological surface states.

  14. Electronic interconnects and devices with topological surface states and methods for fabricating same

    Energy Technology Data Exchange (ETDEWEB)

    Yazdani, Ali; Ong, N. Phuan; Cava, Robert J.

    2016-05-03

    An interconnect is disclosed with enhanced immunity of electrical conductivity to defects. The interconnect includes a material with charge carriers having topological surface states. Also disclosed is a method for fabricating such interconnects. Also disclosed is an integrated circuit including such interconnects. Also disclosed is a gated electronic device including a material with charge carriers having topological surface states.

  15. Topological Hamiltonian as an exact tool for topological invariants.

    Science.gov (United States)

    Wang, Zhong; Yan, Binghai

    2013-04-17

    We propose the concept of 'topological Hamiltonian' for topological insulators and superconductors in interacting systems. The eigenvalues of the topological Hamiltonian are significantly different from the physical energy spectra, but we show that the topological Hamiltonian contains the information of gapless surface states, therefore it is an exact tool for topological invariants.

  16. Scattering-Free Optical Edge States between Heterogeneous Photonic Topological Insulators

    CERN Document Server

    Ma, Tzuhsuan

    2015-01-01

    We propose a set of three simple photonic platforms capable of emulating quantum topologically insulating phases corresponding to Hall, spin-Hall, and valley-Hall effects. It is shown that an interface between any two of these heterogeneous photonic topological insulators supports scattering-free surface states. Spin and valley degrees of freedom characterizing such topologically protected surface waves determine their unique pathways through complex photonic circuits comprised of multiple heterogeneous interfaces.

  17. Fundamentals of algebraic topology

    CERN Document Server

    Weintraub, Steven H

    2014-01-01

    This rapid and concise presentation of the essential ideas and results of algebraic topology follows the axiomatic foundations pioneered by Eilenberg and Steenrod. The approach of the book is pragmatic: while most proofs are given, those that are particularly long or technical are omitted, and results are stated in a form that emphasizes practical use over maximal generality. Moreover, to better reveal the logical structure of the subject, the separate roles of algebra and topology are illuminated. Assuming a background in point-set topology, Fundamentals of Algebraic Topology covers the canon of a first-year graduate course in algebraic topology: the fundamental group and covering spaces, homology and cohomology, CW complexes and manifolds, and a short introduction to homotopy theory. Readers wishing to deepen their knowledge of algebraic topology beyond the fundamentals are guided by a short but carefully annotated bibliography.

  18. Ordered groups and topology

    CERN Document Server

    Clay, Adam

    2016-01-01

    This book deals with the connections between topology and ordered groups. It begins with a self-contained introduction to orderable groups and from there explores the interactions between orderability and objects in low-dimensional topology, such as knot theory, braid groups, and 3-manifolds, as well as groups of homeomorphisms and other topological structures. The book also addresses recent applications of orderability in the studies of codimension-one foliations and Heegaard-Floer homology. The use of topological methods in proving algebraic results is another feature of the book. The book was written to serve both as a textbook for graduate students, containing many exercises, and as a reference for researchers in topology, algebra, and dynamical systems. A basic background in group theory and topology is the only prerequisite for the reader.

  19. Photonic Floquet Topological Insulators

    CERN Document Server

    Rechtsman, Mikael C; Plotnik, Yonatan; Lumer, Yaakov; Nolte, Stefan; Segev, Mordechai; Szameit, Alexander

    2012-01-01

    The topological insulator is a fundamentally new phase of matter, with the striking property that the conduction of electrons occurs only on its surface, not within the bulk, and that conduction is topologically protected. Topological protection, the total lack of scattering of electron waves by disorder, is perhaps the most fascinating and technologically important aspect of this material: it provides robustness that is otherwise known only for superconductors. However, unlike superconductivity and the quantum Hall effect, which necessitate low temperatures or magnetic fields, the immunity to disorder of topological insulators occurs at room temperature and without any external magnetic field. For this reason, topological protection is predicted to have wide-ranging applications in fault-tolerant quantum computing and spintronics. Recently, a large theoretical effort has been directed towards bringing the concept into the domain of photonics: achieving topological protection of light at optical frequencies. ...

  20. Activity in ventral premotor cortex is modulated by vision of own hand in action

    Directory of Open Access Journals (Sweden)

    Luciano Fadiga

    2013-07-01

    Full Text Available Parietal and premotor cortices of the macaque monkey contain distinct populations of neurons which, in addition to their motor discharge, are also activated by visual stimulation. Among these visuomotor neurons, a population of grasping neurons located in the anterior intraparietal area (AIP shows discharge modulation when the own hand is visible during object grasping. Given the dense connections between AIP and inferior frontal regions, we aimed at investigating whether two hand-related frontal areas, ventral premotor area F5 and primary motor cortex (area F1, contain neurons with similar properties. Two macaques were involved in a grasping task executed in various light/dark conditions in which the to-be-grasped object was kept visible by a dim retro-illumination. Approximately 62% of F5 and 55% of F1 motor neurons showed light/dark modulations. To better isolate the effect of hand-related visual input, we introduced two further conditions characterized by kinematic features similar to the dark condition. The scene was briefly illuminated (i during hand preshaping (pre-touch flash, PT-flash and (ii at hand-object contact (touch flash, T-flash. Approximately 48% of F5 and 44% of F1 motor neurons showed a flash-related modulation. Considering flash-modulated neurons in the two flash conditions, ∼40% from F5 and ∼52% from F1 showed stronger activity in PT- than T-flash (PT-flash-dominant, whereas ∼60% from F5 and ∼48% from F1 showed stronger activity in T- than PT-flash (T-flash-dominant. Furthermore, F5, but not F1, flash-dominant neurons were characterized by a higher peak and mean discharge in the preferred flash condition as compared to light and dark conditions. Still considering F5, the distribution of the time of peak discharge was similar in light and preferred flash conditions. This study shows that the frontal cortex contains neurons, previously classified as motor neurons, which are sensitive to the observation of meaningful

  1. Fuzzy Soft Topological Groups

    Directory of Open Access Journals (Sweden)

    S. Nazmul

    2014-03-01

    Full Text Available Notions of Lowen type fuzzy soft topological space are introduced and some of their properties are established in the present paper. Besides this, a combined structure of a fuzzy soft topological space and a fuzzy soft group, which is termed here as fuzzy soft topological group is introduced. Homomorphic images and preimages are also examined. Finally, some definitions and results on fuzzy soft set are studied.

  2. Tilings in topological spaces

    Directory of Open Access Journals (Sweden)

    F. G. Arenas

    1999-01-01

    pairwise-disjoint interiors. Tilings of ℝ2 have received considerable attention (see [2] for a wealth of interesting examples and results as well as an extensive bibliography. On the other hand, the study of tilings of general topological spaces is just beginning (see [1, 3, 4, 6]. We give some generalizations for topological spaces of some results known for certain classes of tilings of topological vector spaces.

  3. Discretization of topological spaces

    OpenAIRE

    Amini, Massoud; Golestani, Nasser

    2014-01-01

    There are several compactification procedures in topology, but there is only one standard discretization, namely, replacing the original topology with the discrete topology. We give a notion of discretization which is dual (in categorical sense) to compactification and give examples of discretizations. Especially, a discretization functor from the category of $\\alpha$-scattered Stonean spaces to the category of discrete spaces is constructed which is the converse of the Stone-\\v{C}ech compact...

  4. Differential topology an introduction

    CERN Document Server

    Gauld, David B

    2006-01-01

    Offering classroom-proven results, Differential Topology presents an introduction to point set topology via a naive version of nearness space. Its treatment encompasses a general study of surgery, laying a solid foundation for further study and greatly simplifying the classification of surfaces.This self-contained treatment features 88 helpful illustrations. Its subjects include topological spaces and properties, some advanced calculus, differentiable manifolds, orientability, submanifolds and an embedding theorem, and tangent spaces. Additional topics comprise vector fields and integral curv

  5. Topological Foundations of Electromagnetism

    CERN Document Server

    Barrett, Terrence W

    2008-01-01

    Topological Foundations of Electromagnetism seeks a fundamental understanding of the dynamics of electromagnetism; and marshals the evidence that in certain precisely defined topological conditions, electromagnetic theory (Maxwell's theory) must be extended or generalized in order to provide an explanation and understanding of, until now, unusual electromagnetic phenomena. Key to this generalization is an understanding of the circumstances under which the so-called A potential fields have physical effects. Basic to the approach taken is that the topological composition of electromagnetic field

  6. Sober Topological Molecular Lattices

    Institute of Scientific and Technical Information of China (English)

    张德学; 李永明

    2003-01-01

    A topological molecular lattice (TML) is a pair (L, T), where L is a completely distributive lattice and r is a subframe of L. There is an obvious forgetful functor from the category TML of TML's to the category Loc of locales. In this note,it is showed that this forgetful functor has a right adjoint. Then, by this adjunction,a special kind of topological molecular lattices called sober topological molecular lattices is introduced and investigated.

  7. Analog circuit design designing dynamic circuit response

    CERN Document Server

    Feucht, Dennis

    2010-01-01

    This second volume, Designing Dynamic Circuit Response builds upon the first volume Designing Amplifier Circuits by extending coverage to include reactances and their time- and frequency-related behavioral consequences.

  8. QCD at Fixed Topology

    CERN Document Server

    Brower, Richard C; Negele, John W; Wiese, U J

    2003-01-01

    Since present Monte Carlo algorithms for lattice QCD may become trapped in a fixed topological charge sector, it is important to understand the effect of calculating at fixed topology. In this work, we show that although the restriction to a fixed topological sector becomes irrelevant in the infinite volume limit, it gives rise to characteristic finite size effects due to contributions from all $\\theta$-vacua. We calculate these effects and show how to extract physical results from numerical data obtained at fixed topology.

  9. Elements of topology

    CERN Document Server

    Singh, Tej Bahadur

    2013-01-01

    Topological SpacesMetric Spaces Topologies Derived Concepts Bases Subspaces Continuity and ProductsContinuityProduct TopologyConnectednessConnected Spaces Components Path-Connected Spaces Local ConnectivityConvergence Sequences Nets Filters Hausdorff SpacesCountability Axioms 1st and 2nd Countable Spaces Separable and Lindelöf SpacesCompactnessCompact Spaces Countably Compact Spaces Compact Metric Spaces Locally Compact Spaces Proper Maps Topological Constructions Quotient Spaces Identification Maps Cones, Suspensions and Joins Wedge Sums and Smash Products Adjunction Spaces Coherent Topologie

  10. Topics in general topology

    CERN Document Server

    Morita, K

    1989-01-01

    Being an advanced account of certain aspects of general topology, the primary purpose of this volume is to provide the reader with an overview of recent developments.The papers cover basic fields such as metrization and extension of maps, as well as newly-developed fields like categorical topology and topological dynamics. Each chapter may be read independently of the others, with a few exceptions. It is assumed that the reader has some knowledge of set theory, algebra, analysis and basic general topology.

  11. Computational topology an introduction

    CERN Document Server

    Edelsbrunner, Herbert

    2010-01-01

    Combining concepts from topology and algorithms, this book delivers what its title promises: an introduction to the field of computational topology. Starting with motivating problems in both mathematics and computer science and building up from classic topics in geometric and algebraic topology, the third part of the text advances to persistent homology. This point of view is critically important in turning a mostly theoretical field of mathematics into one that is relevant to a multitude of disciplines in the sciences and engineering. The main approach is the discovery of topology through alg

  12. Topology for computing

    CERN Document Server

    Zomorodian, Afra J

    2005-01-01

    The emerging field of computational topology utilizes theory from topology and the power of computing to solve problems in diverse fields. Recent applications include computer graphics, computer-aided design (CAD), and structural biology, all of which involve understanding the intrinsic shape of some real or abstract space. A primary goal of this book is to present basic concepts from topology and Morse theory to enable a non-specialist to grasp and participate in current research in computational topology. The author gives a self-contained presentation of the mathematical concepts from a comp

  13. General Topology of the Universe

    OpenAIRE

    Pandya, Aalok

    2002-01-01

    General topology of the universe is descibed. It is concluded that topology of the present universe is greater or stronger than the topology of the universe in the past and topology of the future universe will be stronger or greater than the present topology of the universe. Consequently, the universe remains unbounded.

  14. Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

    DEFF Research Database (Denmark)

    Guzulaitis, Robertas; Alaburda, Aidas; Hounsgaard, Jørn Dybkjær

    2013-01-01

    Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviors in multifunctional networks could be determined by up or down regulation...... of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons...... and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset...

  15. High voltage high repetition rate pulse using Marx topology

    Science.gov (United States)

    Hakki, A.; Kashapov, N.

    2015-06-01

    The paper describes Marx topology using MOSFET transistors. Marx circuit with 10 stages has been done, to obtain pulses about 5.5KV amplitude, and the width of the pulses was about 30μsec with a high repetition rate (PPS > 100), Vdc = 535VDC is the input voltage for supplying the Marx circuit. Two Ferrite ring core transformers were used to control the MOSFET transistors of the Marx circuit (the first transformer to control the charging MOSFET transistors, the second transformer to control the discharging MOSFET transistors).

  16. Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study

    DEFF Research Database (Denmark)

    Bäumer, T; Schippling, S; Kroeger, J;

    2009-01-01

    OBJECTIVE: In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs). METHODS: Adopting the same conditioning-test approach, we used bifocal transcranial magnetic...

  17. Defining network topologies that can achieve biochemical adaptation.

    Science.gov (United States)

    Ma, Wenzhe; Trusina, Ala; El-Samad, Hana; Lim, Wendell A; Tang, Chao

    2009-08-21

    Many signaling systems show adaptation-the ability to reset themselves after responding to a stimulus. We computationally searched all possible three-node enzyme network topologies to identify those that could perform adaptation. Only two major core topologies emerge as robust solutions: a negative feedback loop with a buffering node and an incoherent feedforward loop with a proportioner node. Minimal circuits containing these topologies are, within proper regions of parameter space, sufficient to achieve adaptation. More complex circuits that robustly perform adaptation all contain at least one of these topologies at their core. This analysis yields a design table highlighting a finite set of adaptive circuits. Despite the diversity of possible biochemical networks, it may be common to find that only a finite set of core topologies can execute a particular function. These design rules provide a framework for functionally classifying complex natural networks and a manual for engineering networks. For a video summary of this article, see the PaperFlick file with the Supplemental Data available online.

  18. Analog circuit design designing waveform processing circuits

    CERN Document Server

    Feucht, Dennis

    2010-01-01

    The fourth volume in the set Designing Waveform-Processing Circuits builds on the previous 3 volumes and presents a variety of analog non-amplifier circuits, including voltage references, current sources, filters, hysteresis switches and oscilloscope trigger and sweep circuitry, function generation, absolute-value circuits, and peak detectors.

  19. Decoding Grasping Movements from the Parieto-Frontal Reaching Circuit in the Nonhuman Primate.

    Science.gov (United States)

    Nelissen, Koen; Fiave, Prosper Agbesi; Vanduffel, Wim

    2017-02-18

    Prehension movements typically include a reaching phase, guiding the hand toward the object, and a grip phase, shaping the hand around it. The dominant view posits that these components rely upon largely independent parieto-frontal circuits: a dorso-medial circuit involved in reaching and a dorso-lateral circuit involved in grasping. However, mounting evidence suggests a more complex arrangement, with dorso-medial areas contributing to both reaching and grasping. To investigate the role of the dorso-medial reaching circuit in grasping, we trained monkeys to reach-and-grasp different objects in the dark and determined if hand configurations could be decoded from functional magnetic resonance imaging (MRI) responses obtained from the reaching and grasping circuits. Indicative of their established role in grasping, object-specific grasp decoding was found in anterior intraparietal (AIP) area, inferior parietal lobule area PFG and ventral premotor region F5 of the lateral grasping circuit, and primary motor cortex. Importantly, the medial reaching circuit also conveyed robust grasp-specific information, as evidenced by significant decoding in parietal reach regions (particular V6A) and dorsal premotor region F2. These data support the proposed role of dorso-medial "reach" regions in controlling aspects of grasping and demonstrate the value of complementing univariate with more sensitive multivariate analyses of functional MRI (fMRI) data in uncovering information coding in the brain. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  20. A review of module inverter topologies suitable for photovoltaic system

    DEFF Research Database (Denmark)

    Variath, Reshmi C; Andersen, Michael A. E.; Nielsen, Ole Neis

    2010-01-01

    This paper evaluates eight module inverter topologies and provides an overview of the merits and demerits of each on the basis of circuit level Pspice simulation. The complete system is modeled in Pspice and the model is made as realistic as possible by including the parasitic elements. Only the ...

  1. Distinct Neural Activities in Premotor Cortex during Natural Vocal Behaviors in a New World Primate, the Common Marmoset (Callithrix jacchus).

    Science.gov (United States)

    Roy, Sabyasachi; Zhao, Lingyun; Wang, Xiaoqin

    2016-11-30

    Although evidence from human studies has long indicated the crucial role of the frontal cortex in speech production, it has remained uncertain whether the frontal cortex in nonhuman primates plays a similar role in vocal communication. Previous studies of prefrontal and premotor cortices of macaque monkeys have found neural signals associated with cue- and reward-conditioned vocal production, but not with self-initiated or spontaneous vocalizations (Coudé et al., 2011; Hage and Nieder, 2013), which casts doubt on the role of the frontal cortex of the Old World monkeys in vocal communication. A recent study of marmoset frontal cortex observed modulated neural activities associated with self-initiated vocal production (Miller et al., 2015), but it did not delineate whether these neural activities were specifically attributed to vocal production or if they may result from other nonvocal motor activity such as orofacial motor movement. In the present study, we attempted to resolve these issues and examined single neuron activities in premotor cortex during natural vocal exchanges in the common marmoset (Callithrix jacchus), a highly vocal New World primate. Neural activation and suppression were observed both before and during self-initiated vocal production. Furthermore, by comparing neural activities between self-initiated vocal production and nonvocal orofacial motor movement, we identified a subpopulation of neurons in marmoset premotor cortex that was activated or suppressed by vocal production, but not by orofacial movement. These findings provide clear evidence of the premotor cortex's involvement in self-initiated vocal production in natural vocal behaviors of a New World primate.

  2. Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression?

    Science.gov (United States)

    Kraskov, Alexander; Dancause, Numa; Quallo, Marsha M; Shepherd, Samantha; Lemon, Roger N

    2009-12-24

    The discovery of "mirror neurons" in area F5 of the ventral premotor cortex has prompted many theories as to their possible function. However, the identity of mirror neurons remains unknown. Here, we investigated whether identified pyramidal tract neurons (PTNs) in area F5 of two adult macaques exhibited "mirror-like" activity. About half of the 64 PTNs tested showed significant modulation of their activity while monkeys observed precision grip of an object carried out by an experimenter, with somewhat fewer showing modulation during precision grip without an object or grasping concealed from the monkey. Therefore, mirror-like activity can be transmitted directly to the spinal cord via PTNs. A novel finding is that many PTNs (17/64) showed complete suppression of discharge during action observation, while firing actively when the monkey grasped food rewards. We speculate that this suppression of PTN discharge might be involved in the inhibition of self-movement during action observation. 2009 Elsevier Inc. All rights reserved.

  3. Spatial and viewpoint selectivity for others' observed actions in monkey ventral premotor mirror neurons.

    Science.gov (United States)

    Maranesi, Monica; Livi, Alessandro; Bonini, Luca

    2017-08-15

    The spatial location and viewpoint of observed actions are closely linked in natural social settings. For example, actions observed from a subjective viewpoint necessarily occur within the observer's peripersonal space. Neurophysiological studies have shown that mirror neurons (MNs) of the monkey ventral premotor area F5 can code the spatial location of live observed actions. Furthermore, F5 MN discharge can also be modulated by the viewpoint from which filmed actions are seen. Nonetheless, whether and to what extent MNs can integrate viewpoint and spatial location of live observed actions remains unknown. We addressed this issue by comparing the activity of 148 F5 MNs while macaque monkeys observed an experimenter grasping in three different combinations of viewpoint and spatial location, namely, lateral view in the (1) extrapersonal and (2) peripersonal space and (3) subjective view in the peripersonal space. We found that the majority of MNs were space-selective (60.8%): those selective for the peripersonal space exhibited a preference for the subjective viewpoint both at the single-neuron and population level, whereas space-unselective neurons were view invariant. These findings reveal the existence of a previously neglected link between spatial and viewpoint selectivity in MN activity during live-action observation.

  4. Role of human premotor dorsal region in learning a conditional visuomotor task.

    Science.gov (United States)

    Parikh, Pranav J; Santello, Marco

    2017-01-01

    Conditional learning is an important component of our everyday activities (e.g., handling a phone or sorting work files) and requires identification of the arbitrary stimulus, accurate selection of the motor response, monitoring of the response, and storing in memory of the stimulus-response association for future recall. Learning this type of conditional visuomotor task appears to engage the premotor dorsal region (PMd). However, the extent to which PMd might be involved in specific or all processes of conditional learning is not well understood. Using transcranial magnetic stimulation (TMS), we demonstrate the role of human PMd in specific stages of learning of a novel conditional visuomotor task that required subjects to identify object center of mass using a color cue and to apply appropriate torque on the object at lift onset to minimize tilt. TMS over PMd, but not vertex, increased error in torque exerted on the object during the learning trials. Analyses of digit position and forces further revealed that the slowing in conditional visuomotor learning resulted from impaired monitoring of the object orientation during lift, rather than stimulus identification, thus compromising the ability to accurately reduce performance error across trials. Importantly, TMS over PMd did not alter production of torque based on the recall of learned color-torque associations. We conclude that the role of PMd for conditional learning is highly sensitive to the stage of learning visuomotor associations.

  5. Psychosocial risk factors, pre-motor symptoms and first-time hospitalization with Parkinson's disease

    DEFF Research Database (Denmark)

    Clark, Alice Jessie; Ritz, B; Prescott, E;

    2013-01-01

    BACKGROUND AND PURPOSE: Experimental studies support a link between stress and development of parkinsonian symptoms, but prospective population studies are lacking. The aim of the current study is to determine the effects of several psychosocial factors on the risk of Parkinson's disease (PD), as...... PD. Vital exhaustion may be useful for screening aimed at early detection and when considering disease-modifying therapies in people at high risk of clinical PD.......BACKGROUND AND PURPOSE: Experimental studies support a link between stress and development of parkinsonian symptoms, but prospective population studies are lacking. The aim of the current study is to determine the effects of several psychosocial factors on the risk of Parkinson's disease (PD......), as well as to identify potential pre-motor symptoms for PD in a large prospective cohort study. METHODS: In 1991-1993, a total of 9955 women and men free of PD from the Copenhagen City Heart Study were asked about major life events, economic hardship, social network, impaired sleep and vital exhaustion...

  6. Modulation of physiological mirror activity with transcranial direct current stimulation over dorsal premotor cortex.

    Science.gov (United States)

    Beaulé, Vincent; Tremblay, Sara; Lafleur, Louis-Philippe; Ferland, Marie C; Lepage, Jean-François; Théoret, Hugo

    2016-11-01

    Humans have a natural tendency towards symmetrical movements, which rely on a distributed cortical network that allows for complex unimanual movements. Studies on healthy humans using rTMS have shown that disruption of this network, and particularly the dorsal premotor cortex (dPMC), can result in increased physiological mirror movements. The aim of the present set of experiments was to further investigate the role of dPMC in restricting motor output to the contralateral hand and determine whether physiological mirror movements could be decreased in healthy individuals. Physiological mirror movements were assessed before and after transcranial direct current stimulation (tDCS) over right and left dPMC in three conditions: bilateral, unilateral left and unilateral right stimulation. Mirror EMG activity was assessed immediately before, 0, 10 and 20 min after tDCS. Results show that physiological mirroring increased significantly in the hand ipsilateral to cathodal stimulation during bilateral stimulation of the dPMC, 10 and 20 min after stimulation compared to baseline. There was no significant modulation of physiological mirroring in the hand ipsilateral to anodal stimulation in the bilateral condition or following unilateral anodal or unilateral cathodal stimulation. The present data further implicate the dPMC in the control of unimanual hand movements and show that physiological mirroring can be increased but not decreased with dPMC tDCS.

  7. Single neurons in M1 and premotor cortex directly reflect behavioral interference.

    Directory of Open Access Journals (Sweden)

    Neta Zach

    Full Text Available Some motor tasks, if learned together, interfere with each other's consolidation and subsequent retention, whereas other tasks do not. Interfering tasks are said to employ the same internal model whereas noninterfering tasks use different models. The division of function among internal models, as well as their possible neural substrates, are not well understood. To investigate these questions, we compared responses of single cells in the primary motor cortex and premotor cortex of primates to interfering and noninterfering tasks. The interfering tasks were visuomotor rotation followed by opposing visuomotor rotation. The noninterfering tasks were visuomotor rotation followed by an arbitrary association task. Learning two noninterfering tasks led to the simultaneous formation of neural activity typical of both tasks, at the level of single neurons. In contrast, and in accordance with behavioral results, after learning two interfering tasks, only the second task was successfully reflected in motor cortical single cell activity. These results support the hypothesis that the representational capacity of motor cortical cells is the basis of behavioral interference and division between internal models.

  8. Rule activity related to spatial and numerical magnitudes: comparison of prefrontal, premotor, and cingulate motor cortices.

    Science.gov (United States)

    Eiselt, Anne-Kathrin; Nieder, Andreas

    2014-05-01

    In everyday situations, quantitative rules, such as "greater than/less than," need to be applied to a multitude of magnitude comparisons, be they sensory, spatial, temporal, or numerical. We have previously shown that rules applied to different magnitudes are encoded in the lateral PFC. To investigate if and how other frontal lobe areas also contribute to the encoding of quantitative rules applied to multiple magnitudes, we trained monkeys to switch between "greater than/less than" rules applied to either line lengths (spatial magnitudes) or dot numerosities (discrete numerical magnitudes). We recorded single-cell activity from the dorsal premotor cortex (dPMC) and cingulate motor cortex (CMA) and compared it with PFC activity. We found the largest proportion of quantitative rule-selective cells in PFC (24% of randomly selected cells), whereas neurons in dPMC and CMA rarely encoded the rule (6% of the cells). In addition, rule selectivity of individual cells was highest in PFC neurons compared with dPMC and CMA neurons. Rule-selective neurons that simultaneously represented the "greater than/less than" rules applied to line lengths and numerosities ("rule generalists") were exclusively present in PFC. In dPMC and CMA, however, neurons primarily encoded rules applied to only one of the two magnitude types ("rule specialists"). Our data suggest a special involvement of PFC in representing quantitative rules at an abstract level, both in terms of the proportion of neurons engaged and the coding capacities.

  9. Space-dependent representation of objects and other's action in monkey ventral premotor grasping neurons.

    Science.gov (United States)

    Bonini, Luca; Maranesi, Monica; Livi, Alessandro; Fogassi, Leonardo; Rizzolatti, Giacomo

    2014-03-12

    The macaque ventral premotor area F5 hosts two types of visuomotor grasping neurons: "canonical" neurons, which respond to visually presented objects and underlie visuomotor transformation for grasping, and "mirror" neurons, which respond during the observation of others' action, likely playing a role in action understanding. Some previous evidence suggested that canonical and mirror neurons could be anatomically segregated in different sectors of area F5. Here we investigated the functional properties of single neurons in the hand field of area F5 using various tasks similar to those originally designed to investigate visual responses to objects and actions. By using linear multielectrode probes, we were able to simultaneously record different types of neurons and to precisely localize their cortical depth. We recorded 464 neurons, of which 243 showed visuomotor properties. Canonical and mirror neurons were often present in the same cortical sites; and, most interestingly, a set of neurons showed both canonical and mirror properties, discharging to object presentation as well as during the observation of experimenter's goal-directed acts (canonical-mirror neurons). Typically, visual responses to objects were constrained to the monkey peripersonal space, whereas action observation responses were less space-selective. Control experiments showed that space-constrained coding of objects mostly relies on an operational (action possibility) rather than metric (absolute distance) reference frame. Interestingly, canonical-mirror neurons appear to code object as target for both one's own and other's action, suggesting that they could play a role in predictive representation of others' impending actions.

  10. Direct projections from the dorsal premotor cortex to the superior colliculus in the macaque (macaca mulatta).

    Science.gov (United States)

    Distler, Claudia; Hoffmann, Klaus-Peter

    2015-11-01

    The dorsal premotor cortex (PMd) is part of the cortical network for arm movements during reach-related behavior. Here we investigate the neuronal projections from the PMd to the midbrain superior colliculus (SC), which also contains reach-related neurons, to investigate how the SC integrates into a cortico-subcortical network responsible for initiation and modulation of goal-directed arm movements. By using anterograde transport of neuronal tracers, we found that the PMd projects most strongly to the deep layers of the lateral part of the SC and the underlying reticular formation corresponding to locations where reach-related neurons have been recorded, and from where descending tectofugal projections arise. A somewhat weaker projection targets the intermediate layers of the SC. By contrast, terminals originating from prearcuate area 8 mainly project to the intermediate layers of the SC. Thus, this projection pattern strengthens the view that different compartments in the SC are involved in the control of gaze and in the control or modulation of reaching movements. The PMD-SC projection assists in the participation of the SC in the skeletomotor system and provides the PMd with a parallel path to elicit forelimb movements.

  11. A shared representation of the space near oneself and others in the human premotor cortex.

    Science.gov (United States)

    Brozzoli, Claudio; Gentile, Giovanni; Bergouignan, Loretxu; Ehrsson, H Henrik

    2013-09-23

    Interactions between people require shared high-level cognitive representations of action goals, intentions, and mental states, but do people also share their representation of space? The human ventral premotor (PMv) and parietal cortices contain neuronal populations coding for the execution and observation of actions, analogous to the mirror neurons identified in monkeys. This neuronal system is tuned to the location of the acting person relative to the observer and the target of the action. Therefore, it can be theorized that the observer's brain constructs a low-level, body-centered representation of the space around others similar to one's own peripersonal space representation. Single-cell recordings have reported that parietal visuotactile neurons discharge for objects near specific parts of a monkey's own body and near the corresponding body parts of another individual. In humans, no neuroimaging study has investigated this issue. Here, we identified neuronal populations in the human PMv that encode the space near both one's own hand and another person's hand. The shared peripersonal space representation could support social interactions by coding sensory events, actions, and cognitive processes in a common spatial reference frame.

  12. Inhibitory stimulation of the ventral premotor cortex temporarily interferes with musical beat rate preference.

    Science.gov (United States)

    Kornysheva, Katja; von Anshelm-Schiffer, Anne-Marike; Schubotz, Ricarda I

    2011-08-01

    Behavioral studies suggest that preference for a beat rate (tempo) in auditory sequences is tightly linked to the motor system. However, from a neuroscientific perspective the contribution of motor-related brain regions to tempo preference in the auditory domain remains unclear. A recent fMRI study (Kornysheva et al. [2010]: Hum Brain Mapp 31:48-64) revealed that the activity increase in the left ventral premotor cortex (PMv) is associated with the preference for a tempo of a musical rhythm. The activity increase correlated with how strongly the subjects preferred a tempo. Despite this evidence, it remains uncertain whether an interference with activity in the left PMv affects tempo preference strength. Consequently, we conducted an offline repetitive transcranial magnetic stimulation (rTMS) study, in which the cortical excitability in the left PMv was temporarily reduced. As hypothesized, 0.9 Hz rTMS over the left PMv temporarily affected individual tempo preference strength depending on the individual strength of tempo preference in the control session. Moreover, PMv stimulation temporarily interfered with the stability of individual tempo preference strength within and across sessions. These effects were specific to the preference for tempo in contrast to the preference for timbre, bound to the first half of the experiment following PMv stimulation and could not be explained by an impairment of tempo recognition. Our results corroborate preceding fMRI findings and suggest that activity in the left PMv is part of a network that affects the strength of beat rate preference.

  13. Inhibition of the dorsal premotor cortex does not repair surround inhibition in writer's cramp patients.

    Science.gov (United States)

    Veugen, Lidwien C; Hoffland, Britt S; Stegeman, Dick F; van de Warrenburg, Bart P

    2013-03-01

    Writer's cramp is a task-specific form of focal dystonia, characterized by abnormal movements and postures of the hand and arm during writing. Two consistent abnormalities in its pathophysiology are a loss of surround inhibition and overactivity of the dorsal premotor cortex (PMd). This study aimed to assess a possible link between these two phenomena by investigating whether PMd inhibition leads to an improvement of surround inhibition, in parallel with previously demonstrated writing improvement. Fifteen writer's cramp patients and ten controls performed a simple motor hand task during which surround inhibition was measured using transcranial magnetic stimulation. Motor cortical excitability was measured of the active and surround muscles at three phases of the task. Surround inhibition and writing performance were assessed before and after PMd inhibitory continuous theta burst stimulation. In contrast to healthy controls, patients did not show inhibition of the abductor digiti minimi muscle during movement initiation of the first dorsal interosseus muscle, confirming the loss of surround inhibition. PMd inhibition led to an improvement of writing speed in writer's cramp patients. However, in both groups, no changes in surround inhibition were observed. The results confirm a role for the PMd in the pathophysiology of writer's cramp. We show that PMd inhibition does not lead to restoration of the surround inhibition defect in writer's cramp, despite the improvement in writing. This questions the involvement of the PMd in the loss of surround inhibition, and perhaps also the direct link between surround inhibition and dystonia.

  14. A topological derivative method for topology optimization

    DEFF Research Database (Denmark)

    Norato, J.; Bendsøe, Martin P.; Haber, RB;

    2007-01-01

    resource constraint. A smooth and consistent projection of the region bounded by the level set onto the fictitious analysis domain simplifies the response analysis and enhances the convergence of the optimization algorithm. Moreover, the projection supports the reintroduction of solid material in void......We propose a fictitious domain method for topology optimization in which a level set of the topological derivative field for the cost function identifies the boundary of the optimal design. We describe a fixed-point iteration scheme that implements this optimality criterion subject to a volumetric...... regions, a critical requirement for robust topology optimization. We present several numerical examples that demonstrate compliance minimization of fixed-volume, linearly elastic structures....

  15. Risk of premotor symptoms in patients with newly diagnosed PD: a nationwide, population-based, case-control study in Taiwan.

    Directory of Open Access Journals (Sweden)

    Yu-Hsuan Wu

    Full Text Available To evaluate the risk of premotor symptoms, namely rapid eye movement behavior disorder (RBD, constipation, and depression among patients with newly diagnosed Parkinson disease (PD.A total of 705 PD patients and 2,820 control subjects were selected from the Taiwan National Health Insurance Research Database. Patients were traced back for a maximum of 14 years to determine the diagnoses of RBD, depression, and constipation. Logistic regression analysis was used to identify risk of premotor symptoms for PD. Moreover, subgroup analyses were performed by dividing the patients into a middle-age onset group (≤ 64 years and an old-age onset group (≥ 65 years. The associations between these premotor symptoms and age of PD onset were further examined.An association was found between a history of premotor symptoms and newly diagnosed PD in which a high occurrence of premotor symptoms was identified in PD patients as compared to selected controls (4.3% vs. 1.2% for RBD, 40.4% vs. 24.0% for constipation, and 13.0% vs. 5.1% for depression. The strength of this association remained statistically significant after adjustment for potential confounders (3.69 fold risk for RBD, 2.36 for constipation, and 2.82 for depression, all p < 0.0001. The average interval between premotor symptoms and PD ranged from 4.5 to 6.2 years. RBD and depression carried higher risks for PD in the middle-age onset group than in the old-age onset group (7.20- vs. 2.24-fold risk for RBD, 6.06 vs. 1.40 for depression.The prevalence of premotor symptoms was higher among the PD patients than in the controls. Premotor symptoms appeared to be associated with a higher risk for PD in subjects with an earlier age of onset.

  16. Intraoperative identification of the negative motor network during awake surgery to prevent deficit following brain resection in premotor regions.

    Science.gov (United States)

    Rech, F; Duffau, H; Pinelli, C; Masson, A; Roublot, P; Billy-Jacques, A; Brissart, H; Civit, T

    2017-06-01

    Surgical resection in premotor areas can lead to supplementary motor area syndrome as well as a permanent deficit. However, recent findings suggest a putative role of the negative motor network in those dysfunctions. Our objective was to compare the functional results in two groups of adult patients who underwent the resection of a frontal glioma with and without resection of the negative motor networks. Twelve patients (total of 13 surgeries) were selected for awake surgery for a frontal glioma. Negative motor responses were monitored during surgery at the cortical and subcortical levels. Sites eliciting negative motor responses were first identified then spared (n=8) or removed (n=5) upon oncological requirements. In the group with removal of the negative motor network (n=5), all patients presented a complete supplementary motor area syndrome with akinesia and mutism. At 3months, they all presented bimanual coordination dysfunction and fine movement disorders. In the group with preservation of the negative motor network (n=8), all patients presented transient and slight disorders of speech or upper limb, they all recovered completely at 3months. The negative motor network is a part of a modulatory motor network involved in the occurrence of the supplementary motor area syndrome and the permanent deficit after resection in premotor areas. Then, intraoperative functional cortico-subcortical mapping using direct electrostimulation under awake surgery seems mandatory to avoid deficit in bimanual coordination and fine movements during surgery in premotor areas. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  17. Increased resting state connectivity between ipsilesional motor cortex and contralesional premotor cortex after transcranial direct current stimulation with physical therapy.

    Science.gov (United States)

    Chen, Joyce L; Schlaug, Gottfried

    2016-03-16

    Non-invasive stimulation of the brain using transcranial direct current stimulation (tDCS) during motor rehabilitation can improve the recovery of movements in individuals with stroke. However, the neural substrates that underlie the clinical improvements are not well understood. In this proof-of-principle open-label pilot study, five individuals with stroke received 10 sessions of tDCS while undergoing usual care physical/occupational therapy for the arm and hand. Motor impairment as indexed by the Upper Extremity Fugl Meyer assessment was significantly reduced after the intervention. Resting state fMRI connectivity increased between ipsilesional motor cortex and contralesional premotor cortex after the intervention. These findings provide preliminary evidence that the neural underpinnings of tDCS coupled with rehabilitation exercises, may be mediated by interactions between motor and premotor cortex. The latter, of which has been shown to play an important role in the recovery of movements post-stroke. Our data suggest premotor cortex could be tested as a target region for non-invasive brain-stimulation to enhance connectivity between regions that might be beneficial for stroke motor recovery.

  18. Interaction between the premotor processes of eye and hand movements: possible mechanism underlying eye-hand coordination.

    Science.gov (United States)

    Hiraoka, Koichi; Kurata, Naoatsu; Sakaguchi, Masato; Nonaka, Kengo; Matsumoto, Naoto

    2014-03-01

    Interaction between the execution process of eye movement and that of hand movement must be indispensable for eye-hand coordination. The present study investigated corticospinal excitability in the hand muscles during the premotor processes of eye and/or hand movement to elucidate interaction between these processes. Healthy humans performed a precued reaction task of eye and/or finger movement and motor-evoked potentials in the hand muscles were evoked in the reaction time. Leftward eye movement suppressed corticospinal excitability in the right abductor digiti minimi muscle only when little finger abduction was simultaneously executed. Corticospinal excitability in the first dorsal interosseous muscle was not suppressed by eye movement regardless of whether or not it was accompanied by finger movement. Suppression of corticospinal excitability in the hand muscles induced by eye movement in the premotor period depends on the direction of eye movement, the muscle tested, and the premotor process of the tested muscle. The suppression may reflect interaction between the motor process of eye movement and that of hand movement particularly active during eye-hand coordination tasks during which both processes proceed.

  19. 帕金森病运动前期研究进展%Premotor Phase of Early Parkinson Disease (review)

    Institute of Scientific and Technical Information of China (English)

    焦淑军; 袁红

    2011-01-01

    Clinical, neuroimaging, and pathologic studies suggested that a variety of nonmotor symptoms, such as olfactory dysfunction, dysautonomia, and mood and sleep disorders, can precede the typic motor features of Parkinson disease (PD) by years and, perhaps, even decades.The period when these symptoms arise can be referred as the premotor phase of the disease.This paper reviewed the conception, clinical manifestation, pathology, diogose of the premotor phase of early Parkinson disease.%临床症状学及神经影像学、病理学的资料均提示各种帕金森病(PD)非运动症状(NMS),如嗅觉障碍、自主神经机能异常、情感障碍、睡眠紊乱等,先于运动症状出现数年至十数年,这段时期称为运动前期(premotor phase).本文对帕金森病运动前期概念、临床表现、病理基础、诊断的研究进展做一综述.

  20. Increased resting state connectivity between ipsilesional motor cortex and contralesional premotor cortex after transcranial direct current stimulation with physical therapy

    Science.gov (United States)

    Chen, Joyce L; Schlaug, Gottfried

    2016-01-01

    Non-invasive stimulation of the brain using transcranial direct current stimulation (tDCS) during motor rehabilitation can improve the recovery of movements in individuals with stroke. However, the neural substrates that underlie the clinical improvements are not well understood. In this proof-of-principle open-label pilot study, five individuals with stroke received 10 sessions of tDCS while undergoing usual care physical/occupational therapy for the arm and hand. Motor impairment as indexed by the Upper Extremity Fugl Meyer assessment was significantly reduced after the intervention. Resting state fMRI connectivity increased between ipsilesional motor cortex and contralesional premotor cortex after the intervention. These findings provide preliminary evidence that the neural underpinnings of tDCS coupled with rehabilitation exercises, may be mediated by interactions between motor and premotor cortex. The latter, of which has been shown to play an important role in the recovery of movements post-stroke. Our data suggest premotor cortex could be tested as a target region for non-invasive brain-stimulation to enhance connectivity between regions that might be beneficial for stroke motor recovery. PMID:26980052

  1. Topology in Ordered Phases

    Science.gov (United States)

    Tanda, Satoshi; Matsuyama, Toyoki; Oda, Migaku; Asano, Yasuhiro; Yakubo, Kousuke

    2006-08-01

    I. Topology as universal concept. Optical vorticulture / M. V. Berry. On universality of mathematical structure in nature: topology / T. Matsuyama. Topology in physics / R. Jackiw. Isoholonomic problem and holonomic quantum computation / S. Tanimura -- II. Topological crystals. Topological crystals of NbSe[symbol] / S. Tanda ... [et al.]. Superconducting states on a Möbius strip / M. Hayashi ... [et al.]. Structure analyses of topological crystals using synchrotron radiation / Y. Nogami ... [et al.]. Transport measurement for topological charge density waves / T. Matsuura ... [et al.]. Theoretical study on Little-Parks oscillation in nanoscale superconducting ring / T. Suzuki, M. Hayashi and H. Ebisawa. Frustrated CDW states in topological crystals / K. Kuboki ... [et al.]. Law of growth in topological crystal / M. Tsubota ... [et al.]. Synthesis and electric properties of NbS[symbol]: possibility of room temperature charge density wave devices / H. Nobukane ... [et al.]. How does a single crystal become a Möbius strip? / T. Matsuura ... [et al.]. Development of X-ray analysis method for topological crystals / K. Yamamoto ... [et al.] -- III. Topological materials. Femtosecond-timescale structure dynamics in complex materials: the case of (NbSe[symbol])[symbol]I / D. Dvorsek and D. Mihailovic. Ultrafast dynamics of charge-density-wave in topological crystals / K. Shimatake ... [et al.]. Topology in morphologies of a folded single-chain polymer / Y. Takenaka, D. Baigl and K. Yoshikawa. One to two-dimensional conversion in topological crystals / T. Toshima, K. Inagaki and S. Tanda. Topological change of Fermi surface in Bismuth under high pressure / M. Kasami ... [et al.]. Topological change of 4, 4'-bis[9-dicarbazolyl]-2, 2'-biphenyl (CBP) by international rearrangement / K. S. Son ... [et al.]. Spin dynamics in Heisenberg triangular system VI5 cluster studied by [symbol]H-NMR / Y. Furukawa ... [et al.]. STM/STS on NbSe[symbol] nanotubes / K. Ichimura ...[et al

  2. Cortical Motor Circuits after Piano Training in Adulthood: Neurophysiologic Evidence.

    Science.gov (United States)

    Houdayer, Elise; Cursi, Marco; Nuara, Arturo; Zanini, Sonia; Gatti, Roberto; Comi, Giancarlo; Leocani, Letizia

    2016-01-01

    The neuronal mechanisms involved in brain plasticity after skilled motor learning are not completely understood. We aimed to study the short-term effects of keyboard training in music-naive subjects on the motor/premotor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS). Twelve subjects (experimental group) underwent, before and after a two week-piano training: (1) hand-motor function tests: Jamar, grip and nine-hole peg tests; (2) electroencephalography, evaluating the mu rhythm task-related desynchronization (TRD) during keyboard performance; and (3) TMS, targeting bilateral abductor pollicis brevis (APB) and abductor digiti minimi (ADM), to obtain duration and area of ipsilateral silent period (ISP) during simultaneous tonic contraction of APB and ADM. Data were compared with 13 controls who underwent twice these measurements, in a two-week interval, without undergoing piano training. Every subject in the experimental group improved keyboard performance and left-hand nine-hole peg test scores. Pre-training, ISP durations were asymmetrical, left being longer than right. Post-training, right ISPAPB increased, leading to symmetrical ISPAPB. Mu TRD during motor performance became more focal and had a lesser amplitude than in pre-training, due to decreased activity over ventral premotor cortices. No such changes were evidenced in controls. We demonstrated that a 10-day piano-training was associated with balanced interhemispheric interactions both at rest and during motor activation. Piano training, in a short timeframe, may reshape local and inter-hemispheric motor cortical circuits.

  3. Topological gravitation on graph manifolds

    CERN Document Server

    Mitskievich, N V; Magdaleno, A M Hernández

    2008-01-01

    A model of topological field theory is presented in which the vacuum coupling constants are topological invariants of the four-dimensional spacetime. Thus the coupling constants are theoretically computable, and they indicate the topological structure of our universe.

  4. Introduction to topology

    CERN Document Server

    Mendelson, Bert

    1990-01-01

    Highly regarded for its exceptional clarity, imaginative and instructive exercises, and fine writing style, this concise book offers an ideal introduction to the fundamentals of topology. It provides a simple, thorough survey of elementary topics, starting with set theory and advancing to metric and topological spaces, connectedness, and compactness. 1975 edition.

  5. Topological Design of Protocols

    CERN Document Server

    Jaffe, Arthur; Wozniakowski, Alex

    2016-01-01

    We give a topological simulation for tensor networks that we call the two-string model. In this approach we give a new way to design protocols, and we discover a new multipartite quantum communication protocol. We introduce the notion of topologically compressed transformations. Our new protocol can implement multiple, non-local compressed transformations among multi-parties using one multipartite resource state.

  6. Topological Lattice Actions

    CERN Document Server

    Bietenholz, W; Pepe, M; Wiese, U -J

    2010-01-01

    We consider lattice field theories with topological actions, which are invariant against small deformations of the fields. Some of these actions have infinite barriers separating different topological sectors. Topological actions do not have the correct classical continuum limit and they cannot be treated using perturbation theory, but they still yield the correct quantum continuum limit. To show this, we present analytic studies of the 1-d O(2) and O(3) model, as well as Monte Carlo simulations of the 2-d O(3) model using topological lattice actions. Some topological actions obey and others violate a lattice Schwarz inequality between the action and the topological charge $Q$. Irrespective of this, in the 2-d O(3) model the topological susceptibility $\\chi_t = \\l/V$ is logarithmically divergent in the continuum limit. Still, at non-zero distance the correlator of the topological charge density has a finite continuum limit which is consistent with analytic predictions. Our study shows explicitly that some cla...

  7. Second Topology Symposium

    CERN Document Server

    1988-01-01

    The main subjects of the Siegen Topology Symposium are reflected in this collection of 16 research and expository papers. They center around differential topology and, more specifically, around linking phenomena in 3, 4 and higher dimensions, tangent fields, immersions and other vector bundle morphisms. Manifold categories, K-theory and group actions are also discussed.

  8. Topological quantum chemistry

    Science.gov (United States)

    Bradlyn, Barry; Elcoro, L.; Cano, Jennifer; Vergniory, M. G.; Wang, Zhijun; Felser, C.; Aroyo, M. I.; Bernevig, B. Andrei

    2017-07-01

    Since the discovery of topological insulators and semimetals, there has been much research into predicting and experimentally discovering distinct classes of these materials, in which the topology of electronic states leads to robust surface states and electromagnetic responses. This apparent success, however, masks a fundamental shortcoming: topological insulators represent only a few hundred of the 200,000 stoichiometric compounds in material databases. However, it is unclear whether this low number is indicative of the esoteric nature of topological insulators or of a fundamental problem with the current approaches to finding them. Here we propose a complete electronic band theory, which builds on the conventional band theory of electrons, highlighting the link between the topology and local chemical bonding. This theory of topological quantum chemistry provides a description of the universal (across materials), global properties of all possible band structures and (weakly correlated) materials, consisting of a graph-theoretic description of momentum (reciprocal) space and a complementary group-theoretic description in real space. For all 230 crystal symmetry groups, we classify the possible band structures that arise from local atomic orbitals, and show which are topologically non-trivial. Our electronic band theory sheds new light on known topological insulators, and can be used to predict many more.

  9. Topology optimization approaches

    DEFF Research Database (Denmark)

    Sigmund, Ole; Maute, Kurt

    2013-01-01

    Topology optimization has undergone a tremendous development since its introduction in the seminal paper by Bendsøe and Kikuchi in 1988. By now, the concept is developing in many different directions, including “density”, “level set”, “topological derivative”, “phase field”, “evolutionary...

  10. On topologies over rings

    Directory of Open Access Journals (Sweden)

    Syed M. Fakhruddin

    1985-01-01

    Full Text Available In this note, we show that if a topology F¯ over a ring A satisfies a certain finiteness condition, then the Gabriel topology G¯ generated by F¯ can be explicitly constructed and it also satisfies the same finiteness condition.

  11. Conceptions of Topological Transitivity

    CERN Document Server

    Akin, Ethan

    2011-01-01

    There are several different common definitions of a property in topological dynamics called "topological transitivity," and it is part of the folklore of dynamical systems that under reasonable hypotheses, they are equivalent. Various equivalences are proved in different places, but the full story is difficult to find. This note provides a complete description of the relationships among the different properties.

  12. Modeling Internet Topology Dynamics

    NARCIS (Netherlands)

    Haddadi, H.; Uhlig, S.; Moore, A.; Mortier, R.; Rio, M.

    Despite the large number of papers on network topology modeling and inference, there still exists ambiguity about the real nature of the Internet AS and router level topology. While recent findings have illustrated the inaccuracies in maps inferred from BGP peering and traceroute measurements, exist

  13. Motor control in basal ganglia circuits using fMRI and brain atlas approaches.

    Science.gov (United States)

    Lehéricy, Stéphane; Bardinet, Eric; Tremblay, Leon; Van de Moortele, Pierre-Francois; Pochon, Jean-Baptiste; Dormont, Didier; Kim, Dae-Shik; Yelnik, Jerome; Ugurbil, Kamil

    2006-02-01

    In this study, we examined how the motor, premotor and associative basal ganglia territories process movement parameters such as the complexity and the frequency of movement. Twelve right-handed volunteers were studied using EPI BOLD contrast (3 T) while performing audio-paced finger tapping tasks designed to differentiate basal ganglia territories. Tasks varied movement complexity (repetitive index tapping, simple sequence of finger movements and complex sequence of 10 moves) and frequency (from 0.5 to 3 Hz). Activation maps were coregistered onto a 3-D brain atlas derived from post-mortem brains. Three main patterns of activation were observed. In the posterior putamen and the sensorimotor cortex, signal increased with movement frequency but not with movement complexity. In premotor areas, the anterior putamen and the ventral posterolateral thalamus, signal increased regularly with increasing movement frequency and complexity. In rostral frontal areas, the caudate nucleus, the subthalamic nucleus and the ventral anterior/ventrolateral thalamus, signal increased mainly during the complex task and the high frequency task (3 Hz). These data show the different roles of motor, premotor and associative basal ganglia circuits in the processing of motor-related operations and suggest that activation can be precisely located within the entire circuitry of the basal ganglia.

  14. Hybrid HVDC circuit breaker with self-powered gate drives

    OpenAIRE

    Effah, Francis Boafo; Watson, Alan James; Ji, Chao; Amankwah, Emmanuel K.; Johnson, Christopher Mark; Davidson, Colin; Clare, Jon C.

    2016-01-01

    The ever increasing electric power demand and the advent of renewable energy sources have revived the interest in high-voltage direct current (HVDC) multi-terminal networks. However, the absence of a suitable circuit breaker or fault tolerant VSC station topologies with the required characteristics (such as operating speed) have, until recently, been an obstacle in the development of large scale multi-terminal networks for HVDC. This paper presents a hybrid HVDC circuit breaker concept which...

  15. Hybrid HVDC circuit breaker with self-powered gate drives

    OpenAIRE

    Effah, Francis Boafo; Watson, Alan James; Ji, Chao; Amankwah, Emmanuel K.; Johnson, Christopher Mark; Davidson, Colin; Clare, Jon C.

    2016-01-01

    The ever increasing electric power demand and the advent of renewable energy sources have revived the interest in high-voltage direct current (HVDC) multi-terminal networks. However, the absence of a suitable circuit breaker or fault tolerant VSC station topologies with the required characteristics (such as operating speed) have, until recently, been an obstacle in the development of large scale multi-terminal networks for HVDC. This paper presents a hybrid HVDC circuit breaker concept which ...

  16. Beyond Topologies, Part I

    CERN Document Server

    Rosinger, Elemer E

    2010-01-01

    Arguments on the need, and usefulness, of going beyond the usual Hausdorff-Kuratowski-Bourbaki, or in short, HKB concept of topology are presented. The motivation comes, among others, from well known {\\it topological type processes}, or in short TTP-s, in the theories of Measure, Integration and Ordered Spaces. These TTP-s, as shown by the classical characterization given by the {\\it four Moore-Smith conditions}, can {\\it no longer} be incorporated within the usual HKB topologies. One of the most successful recent ways to go beyond HKB topologies is that developed in Beattie & Butzmann. It is shown in this work how that extended concept of topology is a {\\it particular} case of the earlier one suggested and used by the first author in the study of generalized solutions of large classes of nonlinear partial differential equations.

  17. Interactive Topology Optimization

    DEFF Research Database (Denmark)

    Nobel-Jørgensen, Morten

    software where the users are assumed to be well-educated both in the finite element method and topology optimization. This dissertation describes how various topology optimization methods have been used for creating cross-platform applications with high performance. The user interface design is based......Interactivity is the continuous interaction between the user and the application to solve a task. Topology optimization is the optimization of structures in order to improve stiffness or other objectives. The goal of the thesis is to explore how topology optimization can be used in applications...... in an interactive and intuitive way. By creating such applications with an intuitive and simple user interface we allow non-engineers like designers and architects to easily experiment with boundary conditions, design domains and other optimization settings. This is in contrast to commercial topology optimization...

  18. Topological phase transitions and chiral inelastic transport induced by the squeezing of light

    Science.gov (United States)

    Peano, Vittorio; Houde, Martin; Brendel, Christian; Marquardt, Florian; Clerk, Aashish A.

    2016-01-01

    There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the formation of qualitatively new kinds of topological states. Such states are characterized by non-trivial Chern numbers, and exhibit protected edge modes, which give rise to chiral elastic and inelastic photon transport. These topological bosonic states are not equivalent to their fermionic (topological superconductor) counterparts and, in addition, cannot be mapped by a local transformation onto topological states found in particle-conserving models. They thus represent a new type of topological system. We study this physics in detail in the case of a kagome lattice model, and discuss possible realizations using nonlinear photonic crystals or superconducting circuits. PMID:26931620

  19. Protected gates for topological quantum field theories

    Energy Technology Data Exchange (ETDEWEB)

    Beverland, Michael E.; Pastawski, Fernando; Preskill, John [Institute for Quantum Information and Matter, California Institute of Technology, Pasadena, California 91125 (United States); Buerschaper, Oliver [Dahlem Center for Complex Quantum Systems, Freie Universität Berlin, 14195 Berlin (Germany); Koenig, Robert [Institute for Advanced Study and Zentrum Mathematik, Technische Universität München, 85748 Garching (Germany); Sijher, Sumit [Institute for Quantum Computing and Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario N2L 3G1 (Canada)

    2016-02-15

    We study restrictions on locality-preserving unitary logical gates for topological quantum codes in two spatial dimensions. A locality-preserving operation is one which maps local operators to local operators — for example, a constant-depth quantum circuit of geometrically local gates, or evolution for a constant time governed by a geometrically local bounded-strength Hamiltonian. Locality-preserving logical gates of topological codes are intrinsically fault tolerant because spatially localized errors remain localized, and hence sufficiently dilute errors remain correctable. By invoking general properties of two-dimensional topological field theories, we find that the locality-preserving logical gates are severely limited for codes which admit non-abelian anyons, in particular, there are no locality-preserving logical gates on the torus or the sphere with M punctures if the braiding of anyons is computationally universal. Furthermore, for Ising anyons on the M-punctured sphere, locality-preserving gates must be elements of the logical Pauli group. We derive these results by relating logical gates of a topological code to automorphisms of the Verlinde algebra of the corresponding anyon model, and by requiring the logical gates to be compatible with basis changes in the logical Hilbert space arising from local F-moves and the mapping class group.

  20. Solid-state circuits

    CERN Document Server

    Pridham, G J

    2013-01-01

    Solid-State Circuits provides an introduction to the theory and practice underlying solid-state circuits, laying particular emphasis on field effect transistors and integrated circuits. Topics range from construction and characteristics of semiconductor devices to rectification and power supplies, low-frequency amplifiers, sine- and square-wave oscillators, and high-frequency effects and circuits. Black-box equivalent circuits of bipolar transistors, physical equivalent circuits of bipolar transistors, and equivalent circuits of field effect transistors are also covered. This volume is divided

  1. Simple Autonomous Chaotic Circuits

    Science.gov (United States)

    Piper, Jessica; Sprott, J.

    2010-03-01

    Over the last several decades, numerous electronic circuits exhibiting chaos have been proposed. Non-autonomous circuits with as few as two components have been developed. However, the operation of such circuits relies on the non-ideal behavior of the devices used, and therefore the circuit equations can be quite complex. In this paper, we present two simple autonomous chaotic circuits using only opamps and linear passive components. The circuits each use one opamp as a comparator, to provide a signum nonlinearity. The chaotic behavior is robust, and independent of nonlinearities in the passive components. Moreover, the circuit equations are among the algebraically simplest chaotic systems yet constructed.

  2. Circuit analysis for dummies

    CERN Document Server

    Santiago, John

    2013-01-01

    Circuits overloaded from electric circuit analysis? Many universities require that students pursuing a degree in electrical or computer engineering take an Electric Circuit Analysis course to determine who will ""make the cut"" and continue in the degree program. Circuit Analysis For Dummies will help these students to better understand electric circuit analysis by presenting the information in an effective and straightforward manner. Circuit Analysis For Dummies gives you clear-cut information about the topics covered in an electric circuit analysis courses to help

  3. Designing Low Power Circuits: A Review

    Directory of Open Access Journals (Sweden)

    Rohan M Joshi

    2012-09-01

    Full Text Available The growing market of battery-operated portable applications like laptop, mobile etc requires microelectronic devices with low power consumption. As transistor size continues to shrink and as need for more complex chips increases, power management of the chip is one of the key challenges in VLSI industry. The manufacturers are looking for low power designs because providing adequate cooling and packaging increases the cost and limits the functionality of the device. This paper surveys the optimization techniques used to reduce power consumption in CMOS at all the levels of the design flow. It includes the technology used to implement digital circuits, the circuit design style and topology, the architecture for implementing the circuits, and at the highest level the software and algorithms that are implemented.

  4. Topology optimised planar photonic crystal building blocks

    DEFF Research Database (Denmark)

    Frandsen, Lars Hagedorn; Hede, K. K.; Borel, Peter Ingo

    A photonic crystal waveguide (PhCW) 1x4 splitter has been constructed from PhCW 60° bends1 and Y-splitters2 that have been designed individually by utilising topology optimisation3. The splitter has been fabricated in a silicon-on-insulator material (Fig. 1) and exhibits a broadband splitting...... for the TE-polarisation with an average excess loss of 1.55±0.54 dB for a 110 nm bandwidth. The 1x4 splitter demonstrates that individual topology-optimised parts can be used as building blocks to realise high-performance nanophotonic circuits. 1L. H. Frandsen et al., Opt. Express 12, 5916-5921 (2004) 2P. I...

  5. Current limiter circuit system

    Energy Technology Data Exchange (ETDEWEB)

    Witcher, Joseph Brandon; Bredemann, Michael V.

    2017-09-05

    An apparatus comprising a steady state sensing circuit, a switching circuit, and a detection circuit. The steady state sensing circuit is connected to a first, a second and a third node. The first node is connected to a first device, the second node is connected to a second device, and the steady state sensing circuit causes a scaled current to flow at the third node. The scaled current is proportional to a voltage difference between the first and second node. The switching circuit limits an amount of current that flows between the first and second device. The detection circuit is connected to the third node and the switching circuit. The detection circuit monitors the scaled current at the third node and controls the switching circuit to limit the amount of the current that flows between the first and second device when the scaled current is greater than a desired level.

  6. Direct Probe of Topological Invariants Using Bloch Oscillating Quantum Walks.

    Science.gov (United States)

    Ramasesh, V V; Flurin, E; Rudner, M; Siddiqi, I; Yao, N Y

    2017-03-31

    The topology of a single-particle band structure plays a fundamental role in understanding a multitude of physical phenomena. Motivated by the connection between quantum walks and such topological band structures, we demonstrate that a simple time-dependent, Bloch-oscillating quantum walk enables the direct measurement of topological invariants. We consider two classes of one-dimensional quantum walks and connect the global phase imprinted on the walker with its refocusing behavior. By disentangling the dynamical and geometric contributions to this phase, we describe a general strategy to measure the topological invariant in these quantum walks. As an example, we propose an experimental protocol in a circuit QED architecture where a superconducting transmon qubit plays the role of the coin, while the quantum walk takes place in the phase space of a cavity.

  7. Solenoid-Simulation Circuit

    Science.gov (United States)

    Simon, R. A.

    1986-01-01

    Electrical properties of solenoids imitated for tests of control circuits. Simulation circuit imitates voltage and current responses of two engine-controlling solenoids. Used in tests of programs of digital engine-control circuits, also provides electronic interface with circuits imitating electrical properties of pressure sensors and linear variable-differential transformers. Produces voltages, currents, delays, and discrete turnon and turnoff signals representing operation of solenoid in engine-control relay. Many such circuits used simulating overall engine circuitry.

  8. Enhancing motor network activity using real-time functional MRI neurofeedback of left premotor cortex

    Directory of Open Access Journals (Sweden)

    Theo Ferreira Marins

    2015-12-01

    Full Text Available Neurofeedback by functional Magnetic Resonance Imaging (fMRI is a technique of potential therapeutic relevance that allows individuals to be aware of their own neurophysiological responses and to voluntarily modulate the activity of specific brain regions, such as the premotor cortex (PMC, important for motor recovery after brain injury. We investigated (i whether healthy human volunteers are able to up-regulate the activity of the left PMC during a right hand finger tapping motor imagery (MI task while receiving continuous fMRI-neurofeedback, and (ii whether successful modulation of brain activity influenced non-targeted motor control regions. During the MI task, participants of the neurofeedback group (NFB received ongoing visual feedback representing the level of fMRI responses within their left PMC. Control (CTL group participants were shown similar visual stimuli, but these were non-contingent on brain activity. Both groups showed equivalent levels of behavioral ratings on arousal and motor imagery, before and during the fMRI protocol. In the NFB, but not in CLT group, brain activation during the last run compared to the first run revealed increased activation in the left PMC. In addition, the NFB group showed increased activation in motor control regions extending beyond the left PMC target area, including the supplementary motor area, basal ganglia and cerebellum. Moreover, in the last run, the NFB group showed stronger activation in the left PMC/inferior frontal gyrus when compared to the CTL group. Our results indicate that modulation of PMC and associated motor control areas can be achieved during a single neurofeedback-fMRI session. These results contribute to a better understanding of the underlying mechanisms of MI-based neurofeedback training, with direct implications for rehabilitation strategies in severe brain disorders, such as stroke.

  9. Distinct neural patterns enable grasp types decoding in monkey dorsal premotor cortex

    Science.gov (United States)

    Hao, Yaoyao; Zhang, Qiaosheng; Controzzi, Marco; Cipriani, Christian; Li, Yue; Li, Juncheng; Zhang, Shaomin; Wang, Yiwen; Chen, Weidong; Chiara Carrozza, Maria; Zheng, Xiaoxiang

    2014-12-01

    Objective. Recent studies have shown that dorsal premotor cortex (PMd), a cortical area in the dorsomedial grasp pathway, is involved in grasp movements. However, the neural ensemble firing property of PMd during grasp movements and the extent to which it can be used for grasp decoding are still unclear. Approach. To address these issues, we used multielectrode arrays to record both spike and local field potential (LFP) signals in PMd in macaque monkeys performing reaching and grasping of one of four differently shaped objects. Main results. Single and population neuronal activity showed distinct patterns during execution of different grip types. Cluster analysis of neural ensemble signals indicated that the grasp related patterns emerged soon (200-300 ms) after the go cue signal, and faded away during the hold period. The timing and duration of the patterns varied depending on the behaviors of individual monkey. Application of support vector machine model to stable activity patterns revealed classification accuracies of 94% and 89% for each of the two monkeys, indicating a robust, decodable grasp pattern encoded in the PMd. Grasp decoding using LFPs, especially the high-frequency bands, also produced high decoding accuracies. Significance. This study is the first to specify the neuronal population encoding of grasp during the time course of grasp. We demonstrate high grasp decoding performance in PMd. These findings, combined with previous evidence for reach related modulation studies, suggest that PMd may play an important role in generation and maintenance of grasp action and may be a suitable locus for brain-machine interface applications.

  10. Synaptic and functional linkages between spinal premotor interneurons and hand-muscle activity during precision grip

    Directory of Open Access Journals (Sweden)

    Tomohiko eTakei

    2013-04-01

    Full Text Available Grasping is a highly complex movement that requires the coordination of a number of hand joints and muscles. Previous studies showed that spinal premotor interneurons (PreM-INs in the primate cervical spinal cord have divergent synaptic effects on hand motoneurons and that they might contribute to hand-muscle synergies. However, the extent to which these PreM-IN synaptic connections functionally contribute to modulating hand-muscle activity is not clear. In this paper, we explored the contribution of spinal PreM-INs to hand-muscle activation by quantifying the synaptic linkage (SL and functional linkage (FL of the PreM-INs with hand-muscle activities. The activity of 23 PreM-INs was recorded from the cervical spinal cord (C6–T1, with EMG signals measured simultaneously from hand and arm muscles in two macaque monkeys performing a precision grip task. Spike-triggered averages (STAs of rectified EMGs were compiled for 456 neuron–muscle pairs; 63 pairs showed significant post-spike effects (i.e., SL. Conversely, 231 of 456 pairs showed significant cross-correlations between the IN firing rate and rectified EMG (i.e., FL. Importantly, a greater proportion of the neuron–muscle pairs with SL showed FL (43/63 pairs, 68% compared with the pairs without SL (203/393, 52%, and the presence of SL was significantly associated with that of FL. However, a significant number of pairs had SL without FL (SL∩!FL, n = 20 or FL without SL (!SL∩FL, n = 203, and the proportions of these incongruities exceeded the number expected by chance. These results suggested that spinal PreM-INs function to significantly modulate hand-muscle activity during precision grip, but the contribution of other neural structures is also needed to recruit an adequate combination of hand-muscle motoneurons.

  11. Decoding a wide range of hand configurations from macaque motor, premotor, and parietal cortices.

    Science.gov (United States)

    Schaffelhofer, Stefan; Agudelo-Toro, Andres; Scherberger, Hansjörg

    2015-01-21

    Despite recent advances in decoding cortical activity for motor control, the development of hand prosthetics remains a major challenge. To reduce the complexity of such applications, higher cortical areas that also represent motor plans rather than just the individual movements might be advantageous. We investigated the decoding of many grip types using spiking activity from the anterior intraparietal (AIP), ventral premotor (F5), and primary motor (M1) cortices. Two rhesus monkeys were trained to grasp 50 objects in a delayed task while hand kinematics and spiking activity from six implanted electrode arrays (total of 192 electrodes) were recorded. Offline, we determined 20 grip types from the kinematic data and decoded these hand configurations and the grasped objects with a simple Bayesian classifier. When decoding from AIP, F5, and M1 combined, the mean accuracy was 50% (using planning activity) and 62% (during motor execution) for predicting the 50 objects (chance level, 2%) and substantially larger when predicting the 20 grip types (planning, 74%; execution, 86%; chance level, 5%). When decoding from individual arrays, objects and grip types could be predicted well during movement planning from AIP (medial array) and F5 (lateral array), whereas M1 predictions were poor. In contrast, predictions during movement execution were best from M1, whereas F5 performed only slightly worse. These results demonstrate for the first time that a large number of grip types can be decoded from higher cortical areas during movement preparation and execution, which could be relevant for future neuroprosthetic devices that decode motor plans.

  12. Cardiovascular physiology in pre-motor Parkinson disease: A Neuroepidemiologic study

    Science.gov (United States)

    Jain, S; Ton, TG; Perera, S; Zheng, Y; Stein, PK; Thacker, EL; Strotmeyer, ES; Newman, AB; Longstreth, WT

    2013-01-01

    Background Changes in cardiovascular physiology in PD are common and may occur prior to diagnostic Parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability or carotid stenosis with the risk of Parkinson disease (PD) diagnosis in the Cardiovascular Health Study, a community-based cohort of older adults. Methods ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24-hour Holter monitoring) or any carotid stenosis (≥1%) by ultrasound were modeled as primary predictors for incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least one of the following: self-report, anti-Parkinsonian medication use, or ICD9. If unadjusted models were significant, they were adjusted or stratified for age, sex and smoking status and those in which predictors were still significant (p≤0.05) were additionally adjusted for race, diabetes, total cholesterol, low density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke and C-reactive protein. Results Of 5,888 participants, 154 incident PD cases were identified over 14 years of follow-up. After adjusting models with all covariates, those with any ECG abnormality (Odds Ratio: 1.45, 95% CI: 1.02-2.07,p=0.04) or any carotid stenosis (OR: 2.40, 95% CI (1.40-4.09,p=0.001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. Conclusions This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential pre-motor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset. PMID:22700356

  13. Human left ventral premotor cortex mediates matching of hand posture to object use.

    Directory of Open Access Journals (Sweden)

    Guy Vingerhoets

    Full Text Available Visuomotor transformations for grasping have been associated with a fronto-parietal network in the monkey brain. The human homologue of the parietal monkey region (AIP has been identified as the anterior part of the intraparietal sulcus (aIPS, whereas the putative human equivalent of the monkey frontal region (F5 is located in the ventral part of the premotor cortex (vPMC. Results from animal studies suggest that monkey F5 is involved in the selection of appropriate hand postures relative to the constraints of the task. In humans, the functional roles of aIPS and vPMC appear to be more complex and the relative contribution of each region to grasp selection remains uncertain. The present study aimed to identify modulation in brain areas sensitive to the difficulty level of tool object - hand posture matching. Seventeen healthy right handed participants underwent fMRI while observing pictures of familiar tool objects followed by pictures of hand postures. The task was to decide whether the hand posture matched the functional use of the previously shown object. Conditions were manipulated for level of difficulty. Compared to a picture matching control task, the tool object - hand posture matching conditions conjointly showed increased modulation in several left hemispheric regions of the superior and inferior parietal lobules (including aIPS, the middle occipital gyrus, and the inferior temporal gyrus. Comparison of hard versus easy conditions selectively modulated the left inferior frontal gyrus with peak activity located in its opercular part (Brodmann area (BA 44. We suggest that in the human brain, vPMC/BA44 is involved in the matching of hand posture configurations in accordance with visual and functional demands.

  14. Evidence for a functional subdivision of Premotor Ear-Eye Field (Area 8B.

    Directory of Open Access Journals (Sweden)

    Marco eLanzilotto

    2015-01-01

    Full Text Available The Supplementary Eye Field (SEF and the Frontal Eye Field (FEF have been described as participating in gaze shift control. Recent evidence suggests, however, that other areas of the dorsomedial prefrontal cortex also influence gaze shift. Herein, we have investigated electrically evoked ear- and eye movements from the Premotor Ear-Eye Field, or PEEF (area 8B of macaque monkeys. We stimulated PEEF during spontaneous condition (outside the task performance and during the execution of a visual fixation task (VFT. In the first case, we functionally identified two regions within the PEEF: a core and a belt. In the core region, stimulation elicited forward ear movements; regarding the evoked eye movements, in some penetrations, stimulation elicited contraversive fixed-vectors with a mean amplitude of 5.14°; while in other penetrations, we observed prevalently contralateral goal-directed eye movements having end-points that fell within 15° in respect to the primary eye position. On the contrary, in the belt region, stimulation elicited backward ear movements; regarding the eye movements, in some penetrations stimulation elicited prevalently contralateral goal-directed eye movements having end-points that fell within 15° in respect to the primary eye position, while in the lateral edge of the investigated region, stimulation elicited contralateral goal-directed eye movements having end-points that fell beyond 15° in respect to the primary eye position. Stimulation during VFT either did not elicit eye movements or evoked saccades of only a few degrees. Finally, even though no head rotation movements were observed during the stimulation period, we viewed a relationship between the duration of stimulation and the neck forces exerted by the monkey’s head. We propose an updated vision of the PEEF composed of two functional regions, core and belt, which may be involved in integrating auditory and visual information important to the programming of gaze

  15. Interhemispheric interaction between human dorsal premotor and contralateral primary motor cortex.

    Science.gov (United States)

    Mochizuki, Hitoshi; Huang, Ying-Zu; Rothwell, John C

    2004-11-15

    We used transcranial magnetic stimulation (TMS) in a paired pulse protocol to investigate interhemispheric interactions between the right dorsal premotor (dPM) and left primary motor cortex (M1) using interstimulus intervals of 4, 6, 8, 10, 12, 16 and 20 ms in ten healthy subjects. A conditioning stimulus over right dPM at an intensity of either 90 or 110% resting motor threshold (RMT) suppressed motor-evoked potentials (MEPs) evoked in the first dorsal interosseous (FDI) muscle by stimulation of left M1. Maximum effects occurred for interstimulus intervals (ISIs) of 8-10 ms. There was no effect if the conditioning stimulus was applied 2.5 cm lateral, anterior or medial to dPM. The effect differed from previously described M1 interhemispheric inhibition in that the threshold for the latter was greater than 90% RMT, whereas stimulation of the dPM at the same intensity led to significant inhibition. In addition, voluntary contraction of the left FDI (i.e. contralateral to the conditioning TMS) enhanced interhemispheric inhibition from right M1 but had no effect on the inhibition from right dPM. Finally, conditioning to right dPM at 90% RMT reduced short-interval intracortical inhibition (SICI; at ISI = 2 ms) in left M1 whilst there was no effect if the conditioning stimulus was applied to right M1. We conclude that conditioning TMS over dPM has effects that differ from the previous pattern of interhemispheric inhibition described between bilateral M1s. This may reflect the existence of commissural fibres between dPM and contralateral M1 that may play a role in bimanual coordination.

  16. Balanced Topological Field Theories

    Science.gov (United States)

    Dijkgraaf, R.; Moore, G.

    We describe a class of topological field theories called ``balanced topological field theories''. These theories are associated to moduli problems with vanishing virtual dimension and calculate the Euler character of various moduli spaces. We show that these theories are closely related to the geometry and equivariant cohomology of ``iterated superspaces'' that carry two differentials. We find the most general action for these theories, which turns out to define Morse theory on field space. We illustrate the constructions with numerous examples. Finally, we relate these theories to topological sigma-models twisted using an isometry of the target space.

  17. Balanced Topological Field Theories

    CERN Document Server

    Dijkgraaf, R

    1997-01-01

    We describe a class of topological field theories called ``balanced topological field theories.'' These theories are associated to moduli problems with vanishing virtual dimension and calculate the Euler character of various moduli spaces. We show that these theories are closely related to the geometry and equivariant cohomology of ``iterated superspaces'' that carry two differentials. We find the most general action for these theories, which turns out to define Morse theory on field space. We illustrate the constructions with numerous examples. Finally, we relate these theories to topological sigma-models twisted using an isometry of the target space.

  18. Topological Active Volumes

    Directory of Open Access Journals (Sweden)

    Barreira N

    2005-01-01

    Full Text Available The topological active volumes (TAVs model is a general model for 3D image segmentation. It is based on deformable models and integrates features of region-based and boundary-based segmentation techniques. Besides segmentation, it can also be used for surface reconstruction and topological analysis of the inside of detected objects. The TAV structure is flexible and allows topological changes in order to improve the adjustment to object's local characteristics, find several objects in the scene, and identify and delimit holes in detected structures. This paper describes the main features of the TAV model and shows its ability to segment volumes in an automated manner.

  19. Elementary topology problem textbook

    CERN Document Server

    Viro, O Ya; Netsvetaev, N Yu; Kharlamov, V M

    2008-01-01

    This textbook on elementary topology contains a detailed introduction to general topology and an introduction to algebraic topology via its most classical and elementary segment centered at the notions of fundamental group and covering space. The book is tailored for the reader who is determined to work actively. The proofs of theorems are separated from their formulations and are gathered at the end of each chapter. This makes the book look like a pure problem book and encourages the reader to think through each formulation. A reader who prefers a more traditional style can either find the pr

  20. Experiments in topology

    CERN Document Server

    Barr, Stephen

    1989-01-01

    ""A mathematician named KleinThought the Moebius band was divine.Said he: 'If you glueThe edges of two,You'll get a weird bottle like mine.' "" - Stephen BarrIn this lively book, the classic in its field, a master of recreational topology invites readers to venture into such tantalizing topological realms as continuity and connectedness via the Klein bottle and the Moebius strip. Beginning with a definition of topology and a discussion of Euler's theorem, Mr. Barr brings wit and clarity to these topics:New Surfaces (Orientability, Dimension, The Klein Bottle, etc.)The Shortest Moebius StripThe

  1. From geometry to topology

    CERN Document Server

    Flegg, H Graham

    2001-01-01

    This excellent introduction to topology eases first-year math students and general readers into the subject by surveying its concepts in a descriptive and intuitive way, attempting to build a bridge from the familiar concepts of geometry to the formalized study of topology. The first three chapters focus on congruence classes defined by transformations in real Euclidean space. As the number of permitted transformations increases, these classes become larger, and their common topological properties become intuitively clear. Chapters 4-12 give a largely intuitive presentation of selected topics.

  2. Plasmonics in Topological Insulators

    Directory of Open Access Journals (Sweden)

    Yi-Ping Lai

    2014-04-01

    Full Text Available With strong spin-orbit coupling, topological insulators have an insulating bulk state, characterized by a band gap, and a conducting surface state, characterized by a Dirac cone. Plasmons in topological insulators show high frequency-tunability in the mid-infrared and terahertz spectral regions with transverse spin oscillations, also called “spin-plasmons”. This paper presents a discussion and review of the developments in this field from the fundamental theory of plasmons in bulk, thin-film, and surface-magnetized topological insulators to the techniques of plasmon excitation and future applications.

  3. Topology-driven magnetic quantum phase transition in topological insulators.

    Science.gov (United States)

    Zhang, Jinsong; Chang, Cui-Zu; Tang, Peizhe; Zhang, Zuocheng; Feng, Xiao; Li, Kang; Wang, Li-Li; Chen, Xi; Liu, Chaoxing; Duan, Wenhui; He, Ke; Xue, Qi-Kun; Ma, Xucun; Wang, Yayu

    2013-03-29

    The breaking of time reversal symmetry in topological insulators may create previously unknown quantum effects. We observed a magnetic quantum phase transition in Cr-doped Bi2(SexTe1-x)3 topological insulator films grown by means of molecular beam epitaxy. Across the critical point, a topological quantum phase transition is revealed through both angle-resolved photoemission measurements and density functional theory calculations. We present strong evidence that the bulk band topology is the fundamental driving force for the magnetic quantum phase transition. The tunable topological and magnetic properties in this system are well suited for realizing the exotic topological quantum phenomena in magnetic topological insulators.

  4. Demonstration of OCDM Coder and Variable Bandwidth Filter Using Parallel Topology of Quadruple Series Coupled Microring Resonators

    National Research Council Canada - National Science Library

    Tanaka, K; Kokubun, Y

    2011-01-01

    ...) coding circuit using two wavelength selective switches (WSSs) consisting of quadruple series coupled MRRs laid out in parallel topology and a phase shifter incorporated in the one arm between them...

  5. Pseudo-topological Riesz spaces

    OpenAIRE

    Muller, M. A.(Universidade Estadual de Campinas, IFGW, Campinas, SP, Brazil)

    1997-01-01

    Pseudo-topological spaces (i.e. limit spaces) were defined by Fischer in 1959. Properties of topological Riesz spaces are well-known. In this paper it is shown that if the topology on a Riesz space is replaced by a pseudo-topology more general results are obtained.

  6. Concepts of polymer statistical topology

    CERN Document Server

    Nechaev, S K

    2016-01-01

    I review few conceptual steps in analytic description of topological interactions, which constitute the basis of a new interdisciplinary branch in mathematical physics, "Statistical Topology", emerged at the edge of topology and statistical physics of fluctuating non-phantom rope-like objects. This new branch is called statistical (or probabilistic) topology.

  7. Real topological string amplitudes

    Science.gov (United States)

    Narain, K. S.; Piazzalunga, N.; Tanzini, A.

    2017-03-01

    We discuss the physical superstring correlation functions in type I theory (or equivalently type II with orientifold) that compute real topological string amplitudes. We consider the correlator corresponding to holomorphic derivative of the real topological amplitude G_{χ } , at fixed worldsheet Euler characteristic χ. This corresponds in the low-energy effective action to N=2 Weyl multiplet, appropriately reduced to the orientifold invariant part, and raised to the power g' = -χ + 1. We show that the physical string correlator gives precisely the holomorphic derivative of topological amplitude. Finally, we apply this method to the standard closed oriented case as well, and prove a similar statement for the topological amplitude F_g.

  8. Topological Susceptibility from Slabs

    CERN Document Server

    Bietenholz, Wolfgang; Gerber, Urs

    2015-01-01

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure chi_t even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of chi_t, as we demonstrate with numerical results for non-linear sigma-models.

  9. Topology for analysis

    CERN Document Server

    Wilansky, Albert

    2008-01-01

    Three levels of examples and problems make this volume appropriate for students and professionals. Abundant exercises, ordered and numbered by degree of difficulty, illustrate important topological concepts. 1970 edition.

  10. Hidden circuits and argumentation

    Science.gov (United States)

    Leinonen, Risto; Kesonen, Mikko H. P.; Hirvonen, Pekka E.

    2016-11-01

    Despite the relevance of DC circuits in everyday life and schools, they have been shown to cause numerous learning difficulties at various school levels. In the course of this article, we present a flexible method for teaching DC circuits at lower secondary level. The method is labelled as hidden circuits, and the essential idea underlying hidden circuits is in hiding the actual wiring of DC circuits, but to make their behaviour evident for pupils. Pupils are expected to find out the wiring of the circuit which should enhance their learning of DC circuits. We present two possible ways to utilise hidden circuits in a classroom. First, they can be used to test and enhance pupils’ conceptual understanding when pupils are expected to find out which one of the offered circuit diagram options corresponds to the actual circuit shown. This method aims to get pupils to evaluate the circuits holistically rather than locally, and as a part of that aim this method highlights any learning difficulties of pupils. Second, hidden circuits can be used to enhance pupils’ argumentation skills with the aid of argumentation sheet that illustrates the main elements of an argument. Based on the findings from our co-operating teachers and our own experiences, hidden circuits offer a flexible and motivating way to supplement teaching of DC circuits.

  11. FUZZY NEURAL NETWORK FOR OBJECT IDENTIFICATION ON INTEGRATED CIRCUIT LAYOUTS

    Directory of Open Access Journals (Sweden)

    A. A. Doudkin

    2015-01-01

    Full Text Available Fuzzy neural network model based on neocognitron is proposed to identify layout objects on images of topological layers of integrated circuits. Testing of the model on images of real chip layouts was showed a highеr degree of identification of the proposed neural network in comparison to base neocognitron.

  12. Topological nodal line semimetals

    Science.gov (United States)

    Fang, Chen; Weng, Hongming; Dai, Xi; Fang, Zhong

    2016-11-01

    We review the recent, mainly theoretical, progress in the study of topological nodal line semimetals in three dimensions. In these semimetals, the conduction and the valence bands cross each other along a one-dimensional curve in the three-dimensional Brillouin zone, and any perturbation that preserves a certain symmetry group (generated by either spatial symmetries or time-reversal symmetry) cannot remove this crossing line and open a full direct gap between the two bands. The nodal line(s) is hence topologically protected by the symmetry group, and can be associated with a topological invariant. In this review, (i) we enumerate the symmetry groups that may protect a topological nodal line; (ii) we write down the explicit form of the topological invariant for each of these symmetry groups in terms of the wave functions on the Fermi surface, establishing a topological classification; (iii) for certain classes, we review the proposals for the realization of these semimetals in real materials; (iv) we discuss different scenarios that when the protecting symmetry is broken, how a topological nodal line semimetal becomes Weyl semimetals, Dirac semimetals, and other topological phases; and (v) we discuss the possible physical effects accessible to experimental probes in these materials. Project partially supported by the National Key Research and Development Program of China (Grant Nos. 2016YFA0302400 and 2016YFA0300604), partially by the National Natural Science Foundation of China (Grant Nos. 11274359 and 11422428), the National Basic Research Program of China (Grant No. 2013CB921700), and the “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences (Grant No. XDB07020100).

  13. Fall Foliage Topology Seminars

    CERN Document Server

    1990-01-01

    This book demonstrates the lively interaction between algebraic topology, very low dimensional topology and combinatorial group theory. Many of the ideas presented are still in their infancy, and it is hoped that the work here will spur others to new and exciting developments. Among the many techniques disussed are the use of obstruction groups to distinguish certain exact sequences and several graph theoretic techniques with applications to the theory of groups.

  14. Topological Test Spaces

    OpenAIRE

    Wilce, Alexander

    2004-01-01

    A test space is the set of outcome-sets associated with a collection of experiments. This notion provides a simple mathematical framework for the study of probabilistic theories -- notably, quantum mechanics -- in which one is faced with incommensurable random quantities. In the case of quantum mechanics, the relevant test space, the set of orthonormal bases of a Hilbert space, carries significant topological structure. This paper inaugurates a general study of topological test spaces. Among ...

  15. Topology optimized microbioreactors

    DEFF Research Database (Denmark)

    Schäpper, Daniel; Lencastre Fernandes, Rita; Eliasson Lantz, Anna

    2011-01-01

    . Topology optimization is then used to change the spatial distribution of cells in the reactor in order to optimize for maximal product flow out of the reactor. This distribution accounts for potentially negative effects of, for example, by-product inhibition. We show that the theoretical improvement...... in productivity is at least fivefold compared with the homogeneous reactor. The improvements obtained by applying topology optimization are largest where either nutrition is scarce or inhibition effects are pronounced....

  16. Tunable Topological Phononic Crystals

    KAUST Repository

    Chen, Ze-Guo

    2016-05-27

    Topological insulators first observed in electronic systems have inspired many analogues in photonic and phononic crystals in which remarkable one-way propagation edge states are supported by topologically nontrivial band gaps. Such band gaps can be achieved by breaking the time-reversal symmetry to lift the degeneracy associated with Dirac cones at the corners of the Brillouin zone. Here, we report on our construction of a phononic crystal exhibiting a Dirac-like cone in the Brillouin zone center. We demonstrate that simultaneously breaking the time-reversal symmetry and altering the geometric size of the unit cell result in a topological transition that we verify by the Chern number calculation and edge-mode analysis. We develop a complete model based on the tight binding to uncover the physical mechanisms of the topological transition. Both the model and numerical simulations show that the topology of the band gap is tunable by varying both the velocity field and the geometric size; such tunability may dramatically enrich the design and use of acoustic topological insulators.

  17. Superconducting doped topological materials

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Satoshi, E-mail: sasaki@sanken.osaka-u.ac.jp [Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047 (Japan); Mizushima, Takeshi, E-mail: mizushima@mp.es.osaka-u.ac.jp [Department of Materials Engineering Science, Osaka University, Toyonaka, Osaka 560-8531 (Japan); Department of Physics, Okayama University, Okayama 700-8530 (Japan)

    2015-07-15

    Highlights: • Studies on both normal- and SC-state properties of doped topological materials. • Odd-parity pairing systems with the time-reversal-invariance. • Robust superconductivity in the presence of nonmagnetic impurity scattering. • We propose experiments to identify the existence of Majorana fermions in these SCs. - Abstract: Recently, the search for Majorana fermions (MFs) has become one of the most important and exciting issues in condensed matter physics since such an exotic quasiparticle is expected to potentially give rise to unprecedented quantum phenomena whose functional properties will be used to develop future quantum technology. Theoretically, the MFs may reside in various types of topological superconductor materials that is characterized by the topologically protected gapless surface state which are essentially an Andreev bound state. Superconducting doped topological insulators and topological crystalline insulators are promising candidates to harbor the MFs. In this review, we discuss recent progress and understanding on the research of MFs based on time-reversal-invariant superconducting topological materials to deepen our understanding and have a better outlook on both the search for and realization of MFs in these systems. We also discuss some advantages of these bulk systems to realize MFs including remarkable superconducting robustness against nonmagnetic impurities.

  18. Intuitive analog circuit design

    CERN Document Server

    Thompson, Marc

    2013-01-01

    Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

  19. The circuit designer's companion

    CERN Document Server

    Williams, Tim

    2013-01-01

    The Circuit Designer's Companion covers the theoretical aspects and practices in analogue and digital circuit design. Electronic circuit design involves designing a circuit that will fulfill its specified function and designing the same circuit so that every production model of it will fulfill its specified function, and no other undesired and unspecified function.This book is composed of nine chapters and starts with a review of the concept of grounding, wiring, and printed circuits. The subsequent chapters deal with the passive and active components of circuitry design. These topics are foll

  20. Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.

    Science.gov (United States)

    van Nuenen, Bart F L; Helmich, Rick C; Ferraye, Murielle; Thaler, Avner; Hendler, Talma; Orr-Urtreger, Avi; Mirelman, Anat; Bressman, Susan; Marder, Karen S; Giladi, Nir; van de Warrenburg, Bart P C; Bloem, Bastiaan R; Toni, Ivan

    2012-12-01

    Compensatory cerebral mechanisms can delay motor symptom onset in Parkinson's disease. We aim to characterize these compensatory mechanisms and early disease-related changes by quantifying movement-related cerebral function in subjects at significantly increased risk of developing Parkinson's disease, namely carriers of a leucine-rich repeat kinase 2-G2019S mutation associated with dominantly inherited parkinsonism. Functional magnetic resonance imaging was used to examine cerebral activity evoked during internal selection of motor representations, a core motor deficit in clinically overt Parkinson's disease. Thirty-nine healthy first-degree relatives of Ashkenazi Jewish patients with Parkinson's disease, who carry the leucine-rich repeat kinase 2-G2019S mutation, participated in this study. Twenty-one carriers of the leucine-rich repeat kinase 2-G2019S mutation and 18 non-carriers of this mutation were engaged in a motor imagery task (laterality judgements of left or right hands) known to be sensitive to motor control parameters. Behavioural performance of both groups was matched. Mutation carriers and non-carriers were equally sensitive to the extent and biomechanical constraints of the imagined movements in relation to the current posture of the participants' hands. Cerebral activity differed between groups, such that leucine-rich repeat kinase 2-G2019S carriers had reduced imagery-related activity in the right caudate nucleus and increased activity in the right dorsal premotor cortex. More severe striatal impairment was associated with stronger effective connectivity between the right dorsal premotor cortex and the right extrastriate body area. These findings suggest that altered movement-related activity in the caudate nuclei of leucine-rich repeat kinase 2-G2019S carriers might remain behaviourally latent by virtue of cortical compensatory mechanisms involving long-range connectivity between the dorsal premotor cortex and posterior sensory regions. These

  1. Essentials of topology with applications

    CERN Document Server

    Krantz, Steven G

    2009-01-01

    Fundamentals What Is Topology? First Definitions Mappings The Separation Axioms Compactness Homeomorphisms Connectedness Path-Connectedness Continua Totally Disconnected Spaces The Cantor Set Metric Spaces Metrizability Baire's Theorem Lebesgue's Lemma and Lebesgue NumbersAdvanced Properties of Topological Spaces Basis and Sub-Basis Product Spaces Relative Topology First Countable, Second Countable, and So ForthCompactifications Quotient Topologies Uniformities Morse Theory Proper Mappings Paracompactness An Application to Digital ImagingBasic Algebraic Topology Homotopy Theory Homology Theory

  2. Metaphorical motion in mathematical reasoning: further evidence for pre-motor implementation of structure mapping in abstract domains.

    Science.gov (United States)

    Fields, Chris

    2013-08-01

    The theory of computation and category theory both employ arrow-based notations that suggest that the basic metaphor "state changes are like motions" plays a fundamental role in all mathematical reasoning involving formal manipulations. If this is correct, structure-mapping inferences implemented by the pre-motor action planning system can be expected to be involved in solving any mathematics problems not solvable by table lookups and number line manipulations alone. Available functional imaging studies of multi-digit arithmetic, algebra, geometry and calculus problem solving are consistent with this expectation.

  3. Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial

    Science.gov (United States)

    Batista, Larissa M.; Nogueira, Lídia L. R. F.; de Oliveira, Eliane A.; de Carvalho, Antonio G. C.; Lima, Soriano S.; Santana, Jordânia R. M.; de Lima, Emerson C. C.; Fernández-Calvo, Bernardino

    2017-01-01

    Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex) combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, anodal stimulation on premotor cortex and constraint-induced movement therapy; Group B, anodal stimulation on primary motor cortex and constraint-induced movement therapy; Group C, sham stimulation and constraint-induced movement therapy. Evaluations involved analysis of functional independence, motor recovery, spasticity, gross motor function, and muscle strength. Results. A significant improvement in primary outcome (functional independence) after treatment in the premotor group followed by primary motor group and sham group was observed. The same pattern of improvement was highlighted among all secondary outcome measures regarding the superior performance of the premotor group over primary motor and sham groups. Conclusions. Premotor cortex can contribute to motor function in patients with severe functional disabilities in early stages of stroke. This study was registered in ClinicalTrials.gov database (NCT 02628561). PMID:28250992

  4. Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial.

    Science.gov (United States)

    Andrade, Suellen M; Batista, Larissa M; Nogueira, Lídia L R F; de Oliveira, Eliane A; de Carvalho, Antonio G C; Lima, Soriano S; Santana, Jordânia R M; de Lima, Emerson C C; Fernández-Calvo, Bernardino

    2017-01-01

    Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex) combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, anodal stimulation on premotor cortex and constraint-induced movement therapy; Group B, anodal stimulation on primary motor cortex and constraint-induced movement therapy; Group C, sham stimulation and constraint-induced movement therapy. Evaluations involved analysis of functional independence, motor recovery, spasticity, gross motor function, and muscle strength. Results. A significant improvement in primary outcome (functional independence) after treatment in the premotor group followed by primary motor group and sham group was observed. The same pattern of improvement was highlighted among all secondary outcome measures regarding the superior performance of the premotor group over primary motor and sham groups. Conclusions. Premotor cortex can contribute to motor function in patients with severe functional disabilities in early stages of stroke. This study was registered in ClinicalTrials.gov database (NCT 02628561).

  5. Do premotor interneurons act in parallel on spinal motoneurons and on dorsal horn spinocerebellar and spinocervical tract neurons in the cat?

    Science.gov (United States)

    Krutki, Piotr; Jelen, Sabina; Jankowska, Elzbieta

    2011-04-01

    It has previously been established that ventral spinocerebellar tract (VSCT) neurons and dorsal spinocerebellar tract neurons located in Clarke's column (CC DSCT neurons) forward information on actions of premotor interneurons in reflex pathways from muscle afferents on α-motoneurons. Whether DSCT neurons located in the dorsal horn (dh DSCT neurons) and spinocervical tract (SCT) neurons are involved in forwarding similar feedback information has not yet been investigated. The aim of the present study was therefore to examine the input from premotor interneurons to these neurons. Electrical stimuli were applied within major hindlimb motor nuclei to activate axon-collaterals of interneurons projecting to these nuclei, and intracellular records were obtained from dh DSCT and SCT neurons. Direct actions of the stimulated interneurons were differentiated from indirect actions by latencies of postsynaptic potentials evoked by intraspinal stimuli and by the absence or presence of temporal facilitation. Direct actions of premotor interneurons were found in a smaller proportion of dh DSCT than of CC DSCT neurons. However, they were evoked by both excitatory and inhibitory interneurons, whereas only inhibitory premotor interneurons were previously found to affect CC DSCT neurons [as indicated by monosynaptic excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) in dh DSCT and only IPSPs in CC DSCT neurons]. No effects of premotor interneurons were found in SCT neurons, since monosynaptic EPSPs or IPSPs were only evoked in them by stimuli applied outside motor nuclei. The study thus reveals a considerable differentiation of feedback information provided by different populations of ascending tract neurons.

  6. Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Suellen M. Andrade

    2017-01-01

    Full Text Available Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, anodal stimulation on premotor cortex and constraint-induced movement therapy; Group B, anodal stimulation on primary motor cortex and constraint-induced movement therapy; Group C, sham stimulation and constraint-induced movement therapy. Evaluations involved analysis of functional independence, motor recovery, spasticity, gross motor function, and muscle strength. Results. A significant improvement in primary outcome (functional independence after treatment in the premotor group followed by primary motor group and sham group was observed. The same pattern of improvement was highlighted among all secondary outcome measures regarding the superior performance of the premotor group over primary motor and sham groups. Conclusions. Premotor cortex can contribute to motor function in patients with severe functional disabilities in early stages of stroke. This study was registered in ClinicalTrials.gov database (NCT 02628561.

  7. Topological Photonic States

    Science.gov (United States)

    He, Cheng; Lin, Liang; Sun, Xiao-Chen; Liu, Xiao-Ping; Lu, Ming-Hui; Chen, Yan-Feng

    2014-01-01

    As exotic phenomena in optics, topological states in photonic crystals have drawn much attention due to their fundamental significance and great potential applications. Because of the broken time-reversal symmetry under the influence of an external magnetic field, the photonic crystals composed of magneto-optical materials will lead to the degeneracy lifting and show particular topological characters of energy bands. The upper and lower bulk bands have nonzero integer topological numbers. The gapless edge states can be realized to connect two bulk states. This topological photonic states originated from the topological property can be analogous to the integer quantum Hall effect in an electronic system. The gapless edge state only possesses a single sign of gradient in the whole Brillouin zone, and thus the group velocity is only in one direction leading to the one-way energy flow, which is robust to disorder and impurity due to the nontrivial topological nature of the corresponding electromagnetic states. Furthermore, this one-way edge state would cross the Brillouin center with nonzero group velocity, where the negative-zero-positive phase velocity can be used to realize some interesting phenomena such as tunneling and backward phase propagation. On the other hand, under the protection of time-reversal symmetry, a pair of gapless edge states can also be constructed by using magnetic-electric coupling meta-materials, exhibiting Fermion-like spin helix topological edge states, which can be regarded as an optical counterpart of topological insulator originating from the spin-orbit coupling. The aim of this article is to have a comprehensive review of recent research literatures published in this emerging field of photonic topological phenomena. Photonic topological states and their related phenomena are presented and analyzed, including the chiral edge states, polarization dependent transportation, unidirectional waveguide and nonreciprocal optical transmission, all

  8. Microwave RF antennas and circuits nonlinearity applications in engineering

    CERN Document Server

    Aluf, Ofer

    2017-01-01

    This book describes a new concept for analyzing RF/microwave circuits, which includes RF/microwave antennas. The book is unique in its emphasis on practical and innovative microwave RF engineering applications. The analysis is based on nonlinear dynamics and chaos models and shows comprehensive benefits and results. All conceptual RF microwave circuits and antennas are innovative and can be broadly implemented in engineering applications. Given the dynamics of RF microwave circuits and antennas, they are suitable for use in a broad range of applications. The book presents analytical methods for microwave RF antennas and circuit analysis, concrete examples, and geometric examples. The analysis is developed systematically, starting with basic differential equations and their bifurcations, and subsequently moving on to fixed point analysis, limit cycles and their bifurcations. Engineering applications include microwave RF circuits and antennas in a variety of topological structures, RFID ICs and antennas, micros...

  9. A New Cost-Effective Multi-Drive Solution based on a Two-Stage Direct Power Electronic Conversion Topology

    DEFF Research Database (Denmark)

    Klumpner, Christian; Blaabjerg, Frede

    2002-01-01

    of a protection circuit involving twelve diodes with full voltage/current ratings used only during faulty situations, makes this topology not so attractive. Lately, two stage Direct Power Electronic Conversion (DPEC) topologies have been proposed, providing similar functionality as a matrix converter but allowing...

  10. Electrical Circuits and Water Analogies

    Science.gov (United States)

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  11. New Voltage-Mode All-pass Filter Topology Employing Single Current Operational Amplifier

    Directory of Open Access Journals (Sweden)

    Hasan Çiçekli

    2016-02-01

    Full Text Available In this paper, a new voltage-mode all-pass filter topology based on single current operational amplifier (COA and the implementation of COA by using current conveyors are presented. The proposed topology employs three admittances and single active circuit element. COA implementation by using current conveyor blocks as sub-circuit contributes to workability of the COA employing circuits by using commercially available integrated circuits that can be employed as current conveyor. The validity of the proposed filter is verified by PSPICE simulation programme by using the MOSIS 0.35 micron CMOS process parameters. The simulation results agree well with the theoretical analysis and the circuit achieve a good total harmonic distortion (THD performance.

  12. Boosting functionality of synthetic DNA circuits with tailored deactivation.

    Science.gov (United States)

    Montagne, Kevin; Gines, Guillaume; Fujii, Teruo; Rondelez, Yannick

    2016-11-15

    Molecular programming takes advantage of synthetic nucleic acid biochemistry to assemble networks of reactions, in vitro, with the double goal of better understanding cellular regulation and providing information-processing capabilities to man-made chemical systems. The function of molecular circuits is deeply related to their topological structure, but dynamical features (rate laws) also play a critical role. Here we introduce a mechanism to tune the nonlinearities associated with individual nodes of a synthetic network. This mechanism is based on programming deactivation laws using dedicated saturable pathways. We demonstrate this approach through the conversion of a single-node homoeostatic network into a bistable and reversible switch. Furthermore, we prove its generality by adding new functions to the library of reported man-made molecular devices: a system with three addressable bits of memory, and the first DNA-encoded excitable circuit. Specific saturable deactivation pathways thus greatly enrich the functional capability of a given circuit topology.

  13. Electronic circuits modeling using artificial neural networks

    Directory of Open Access Journals (Sweden)

    Andrejević Miona V.

    2003-01-01

    Full Text Available In this paper artificial neural networks (ANN are applied to modeling of electronic circuits. ANNs are used for application of the black-box modeling concept in the time domain. Modeling process is described, so the topology of the ANN, the testing signal used for excitation, together with the complexity of ANN are considered. The procedure is first exemplified in modeling of resistive circuits. MOS transistor, as a four-terminal device, is modeled. Then nonlinear negative resistive characteristic is modeled in order to be used as a piece-wise linear resistor in Chua's circuit. Examples of modeling nonlinear dynamic circuits are given encompassing a variety of modeling problems. A nonlinear circuit containing quartz oscillator is considered for modeling. Verification of the concept is performed by verifying the ability of the model to generalize i.e. to create acceptable responses to excitations not used during training. Implementation of these models within a behavioral simulator is exemplified. Every model is implemented in realistic surrounding in order to show its interaction, and of course, its usage and purpose.

  14. Circuits on Cylinders

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Miltersen, Peter Bro; Vinay, V

    2006-01-01

    We consider the computational power of constant width polynomial size cylindrical circuits and nondeterministic branching programs. We show that every function computed by a Pi2 o MOD o AC0 circuit can also be computed by a constant width polynomial size cylindrical nondeterministic branching...... program (or cylindrical circuit) and that every function computed by a constant width polynomial size cylindrical circuit belongs to ACC0....

  15. Electric circuits essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Electric Circuits I includes units, notation, resistive circuits, experimental laws, transient circuits, network theorems, techniques of circuit analysis, sinusoidal analysis, polyph

  16. Countable Fuzzy Topological Space and Countable Fuzzy Topological Vector Space

    Directory of Open Access Journals (Sweden)

    Apu Kumar Saha

    2015-06-01

    Full Text Available This paper deals with countable fuzzy topological spaces, a generalization of the notion of fuzzy topological spaces. A collection of fuzzy sets F on a universe X forms a countable fuzzy topology if in the definition of a fuzzy topology, the condition of arbitrary supremum is relaxed to countable supremum. In this generalized fuzzy structure, the continuity of fuzzy functions and some other related properties are studied. Also the class of countable fuzzy topological vector spaces as a generalization of the class of fuzzy topological vector spaces has been introduced and investigated.

  17. Piezoelectric drive circuit

    Science.gov (United States)

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  18. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, S.M.; Vertregt, Maarten

    2010-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  19. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, S.M.; Vertregt, Maarten

    2011-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  20. Load testing circuit

    DEFF Research Database (Denmark)

    2009-01-01

    A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

  1. Short-circuit logic

    NARCIS (Netherlands)

    Bergstra, J.A.; Ponse, A.

    2010-01-01

    Short-circuit evaluation denotes the semantics of propositional connectives in which the second argument is only evaluated if the first argument does not suffice to determine the value of the expression. In programming, short-circuit evaluation is widely used. A short-circuit logic is a variant of p

  2. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, Simon Minze; Vertregt, Maarten

    2011-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  3. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, Simon Minze; Vertregt, Maarten

    2010-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  4. p-topological Cauchy completions

    Directory of Open Access Journals (Sweden)

    J. Wig

    1999-01-01

    Full Text Available The duality between “regular” and “topological” as convergence space properties extends in a natural way to the more general properties “p-regular” and “p-topological.” Since earlier papers have investigated regular, p-regular, and topological Cauchy completions, we hereby initiate a study of p-topological Cauchy completions. A p-topological Cauchy space has a p-topological completion if and only if it is “cushioned,” meaning that each equivalence class of nonconvergent Cauchy filters contains a smallest filter. For a Cauchy space allowing a p-topological completion, it is shown that a certain class of Reed completions preserve the p-topological property, including the Wyler and Kowalsky completions, which are, respectively, the finest and the coarsest p-topological completions. However, not all p-topological completions are Reed completions. Several extension theorems for p-topological completions are obtained. The most interesting of these states that any Cauchy-continuous map between Cauchy spaces allowing p-topological and p′-topological completions, respectively, can always be extended to a θ-continuous map between any p-topological completion of the first space and any p′-topological completion of the second.

  5. WPG-Controlled Quantum BDD Circuits with BDD Architecture on GaAs-Based Hexagonal Nanowire Network Structure

    National Research Council Canada - National Science Library

    ZHao, Hong-Quan; Kasai, Seiya

    2012-01-01

    .... Binary-decision-diagram- (BDD-) based arithmetic logic unit (ALU) is realized on GaAs-based regular nanowire network with hexagonal topology by the same fabrication method as that of the quantum devices and basic circuits...

  6. Symmetry-protected topological entanglement

    Science.gov (United States)

    Marvian, Iman

    2017-01-01

    We propose an order parameter for the symmetry-protected topological (SPT) phases which are protected by Abelian on-site symmetries. This order parameter, called the SPT entanglement, is defined as the entanglement between A and B , two distant regions of the system, given that the total charge (associated with the symmetry) in a third region C is measured and known, where C is a connected region surrounded by A , B , and the boundaries of the system. In the case of one-dimensional systems we prove that in the limit where A and B are large and far from each other compared to the correlation length, the SPT entanglement remains constant throughout a SPT phase, and furthermore, it is zero for the trivial phase while it is nonzero for all the nontrivial phases. Moreover, we show that the SPT entanglement is invariant under the low-depth quantum circuits which respect the symmetry, and hence it remains constant throughout a SPT phase in the higher dimensions as well. Also, we show that there is an intriguing connection between SPT entanglement and the Fourier transform of the string order parameters, which are the traditional tool for detecting SPT phases. This leads to an algorithm for extracting the relevant information about the SPT phase of the system from the string order parameters. Finally, we discuss implications of our results in the context of measurement-based quantum computation.

  7. Activation and connectivity patterns of the presupplementary and dorsal premotor areas during free improvisation of melodies and rhythms.

    Science.gov (United States)

    de Manzano, Örjan; Ullén, Fredrik

    2012-10-15

    Free, i.e. non-externally cued generation of movement sequences is fundamental to human behavior. We have earlier hypothesized that the dorsal premotor cortex (PMD), which has been consistently implicated in cognitive aspects of planning and selection of spatial motor sequences may be particularly important for the free generation of spatial movement sequences, whereas the pre-supplementary motor area (pre-SMA), which shows increased activation during perception, learning and reproduction of temporal sequences, may contribute more to the generation of temporal structures. Here we test this hypothesis using fMRI and musical improvisation in professional pianists as a model behavior. We employed a 2 × 2 factorial design with the factors Melody (Specified/Improvised) and Rhythm (Specified/Improvised). The main effect analyses partly confirmed our hypothesis: there was a main effect of Melody in the PMD; the pre-SMA was present in the main effect of Rhythm, as predicted, as well as in the main effect of Melody. A psychophysiological interaction analysis of functional connectivity demonstrated that the correlation in activity between the pre-SMA and cerebellum was higher during rhythmic improvisation than during the other conditions. In summary, there were only subtle differences in activity level between the pre-SMA and PMD during improvisation, regardless of condition. Consequently, the free generation of rhythmic and melodic structures, appears to be largely integrated processes but the functional connectivity between premotor areas and other regions may change during free generation in response to sequence-specific spatiotemporal demands.

  8. Different distal-proximal movement balances in right- and left-hand writing may hint at differential premotor cortex involvement.

    Science.gov (United States)

    Potgieser, A R E; de Jong, B M

    2011-12-01

    Right-handed people generally write with their right hand. Language expressed in script is thus performed with the hand also preferred for skilled motor tasks. This may suggest an efficient functional interaction between the language area of Broca and the adjacent ventral premotor cortex (PMv) in the left (dominant) hemisphere. Pilot observations suggested that distal movements are particularly implicated in cursive writing with the right hand and proximal movements in left-hand writing, which generated ideas concerning hemisphere-specific roles of PMv and dorsal premotor cortex (PMd). Now we examined upper-limb movements in 30 right-handed participants during right- and left-hand writing, respectively. Quantitative description of distal and proximal movements demonstrated a significant difference between movements in right- and left-hand writing (pwriting with the right hand, while proximal and distal movements similarly contributed to left-hand writing. Although differences between non-language drawings were not tested, we propose that the DME in right-hand writing may reflect functional dominance of PMv in the left hemisphere. More proximal movements in left-hand writing might be related to PMd dominance in right-hemisphere motor control, logically implicated in spatial visuomotor transformations as seen in reaching.

  9. Synthesizing genetic sequential logic circuit with clock pulse generator.

    Science.gov (United States)

    Chuang, Chia-Hua; Lin, Chun-Liang

    2014-05-28

    Rhythmic clock widely occurs in biological systems which controls several aspects of cell physiology. For the different cell types, it is supplied with various rhythmic frequencies. How to synthesize a specific clock signal is a preliminary but a necessary step to further development of a biological computer in the future. This paper presents a genetic sequential logic circuit with a clock pulse generator based on a synthesized genetic oscillator, which generates a consecutive clock signal whose frequency is an inverse integer multiple to that of the genetic oscillator. An analogous electronic waveform-shaping circuit is constructed by a series of genetic buffers to shape logic high/low levels of an oscillation input in a basic sinusoidal cycle and generate a pulse-width-modulated (PWM) output with various duty cycles. By controlling the threshold level of the genetic buffer, a genetic clock pulse signal with its frequency consistent to the genetic oscillator is synthesized. A synchronous genetic counter circuit based on the topology of the digital sequential logic circuit is triggered by the clock pulse to synthesize the clock signal with an inverse multiple frequency to the genetic oscillator. The function acts like a frequency divider in electronic circuits which plays a key role in the sequential logic circuit with specific operational frequency. A cascaded genetic logic circuit generating clock pulse signals is proposed. Based on analogous implement of digital sequential logic circuits, genetic sequential logic circuits can be constructed by the proposed approach to generate various clock signals from an oscillation signal.

  10. Microscale vortex laser with controlled topological charge

    Science.gov (United States)

    Wang, Xing-Yuan; Chen, Hua-Zhou; Li, Ying; Li, Bo; Ma, Ren-Min

    2016-12-01

    A microscale vortex laser is a new type of coherent light source with small footprint that can directly generate vector vortex beams. However, a microscale laser with controlled topological charge, which is crucial for virtually any of its application, is still unrevealed. Here we present a microscale vortex laser with controlled topological charge. The vortex laser eigenmode was synthesized in a metamaterial engineered non-Hermitian micro-ring cavity system at exceptional point. We also show that the vortex laser cavity can operate at exceptional point stably to lase under optical pumping. The microscale vortex laser with controlled topological charge can serve as a unique and general building block for next-generation photonic integrated circuits and coherent vortex beam sources. The method we used here can be employed to generate lasing eigenmode with other complex functionalities. Project supported by the “Youth 1000 Talent Plan” Fund, Ministry of Education of China (Grant No. 201421) and the National Natural Science Foundation of China (Grant Nos. 11574012 and 61521004).

  11. Topology theory on rough sets.

    Science.gov (United States)

    Wu, QingE; Wang, Tuo; Huang, YongXuan; Li, JiSheng

    2008-02-01

    For further studying the theories and applications of rough sets (RS), this paper proposes a new theory on RS, which mainly includes topological space, topological properties, homeomorphism, and its properties on RS by some new definitions and theorems given. The relationship between partition and countable open covering is discussed, and some applications based on the topological rough space and its topological properties are introduced. Moreover, some perspectives for future research are given. Throughout this paper, the advancements of the new theory on RS and topological algebra not only represent an important theoretical value but also exhibit significant applications of RS and topology.

  12. Nociceptive afferents to the premotor neurons that send axons simultaneously to the facial and hypoglossal motoneurons by means of axon collaterals.

    Directory of Open Access Journals (Sweden)

    Yulin Dong

    Full Text Available It is well known that the brainstem premotor neurons of the facial nucleus and hypoglossal nucleus coordinate orofacial nociceptive reflex (ONR responses. However, whether the brainstem PNs receive the nociceptive projection directly from the caudal spinal trigeminal nucleus is still kept unclear. Our present study focuses on the distribution of premotor neurons in the ONR pathways of rats and the collateral projection of the premotor neurons which are involved in the brainstem local pathways of the orofacial nociceptive reflexes of rat. Retrograde tracer Fluoro-gold (FG or FG/tetramethylrhodamine-dextran amine (TMR-DA were injected into the VII or/and XII, and anterograde tracer biotinylated dextran amine (BDA was injected into the caudal spinal trigeminal nucleus (Vc. The tracing studies indicated that FG-labeled neurons receiving BDA-labeled fibers from the Vc were mainly distributed bilaterally in the parvicellular reticular formation (PCRt, dorsal and ventral medullary reticular formation (MdD, MdV, supratrigeminal nucleus (Vsup and parabrachial nucleus (PBN with an ipsilateral dominance. Some FG/TMR-DA double-labeled premotor neurons, which were observed bilaterally in the PCRt, MdD, dorsal part of the MdV, peri-motor nucleus regions, contacted with BDA-labeled axonal terminals and expressed c-fos protein-like immunoreactivity which induced by subcutaneous injection of formalin into the lip. After retrograde tracer wheat germ agglutinated horseradish peroxidase (WGA-HRP was injected into VII or XII and BDA into Vc, electron microscopic study revealed that some BDA-labeled axonal terminals made mainly asymmetric synapses on the dendritic and somatic profiles of WGA-HRP-labeled premotor neurons. These data indicate that some premotor neurons could integrate the orofacial nociceptive input from the Vc and transfer these signals simultaneously to different brainstem motonuclei by axonal collaterals.

  13. Topological Induced Gravity

    CERN Document Server

    Oda, Ichiro

    2016-01-01

    We propose a topological model of induced gravity (pregeometry) where both Newton's coupling constant and the cosmological constant appear as integration constants in solving field equations. The matter sector of a scalar field is also considered, and by solving field equations it is shown that various types of cosmological solutions in the FRW universe can be obtained. A detailed analysis is given of the meaning of the BRST transformations, which make the induced gravity be a topological field theory, by means of the canonical quantization analysis, and the physical reason why such BRST transformations are needed in the present formalism is clarified. Finally, we propose a dynamical mechanism for fixing the Lagrange multiplier fields by following the Higgs mechanism. The present study clearly indicates that the induced gravity can be constructed at the classical level without recourse to quantum fluctuations of matter and suggests an interesting relationship between the induced gravity and the topological qu...

  14. Topology, calculus and approximation

    CERN Document Server

    Komornik, Vilmos

    2017-01-01

    Presenting basic results of topology, calculus of several variables, and approximation theory which are rarely treated in a single volume, this textbook includes several beautiful, but almost forgotten, classical theorems of Descartes, Erdős, Fejér, Stieltjes, and Turán. The exposition style of Topology, Calculus and Approximation follows the Hungarian mathematical tradition of Paul Erdős and others. In the first part, the classical results of Alexandroff, Cantor, Hausdorff, Helly, Peano, Radon, Tietze and Urysohn illustrate the theories of metric, topological and normed spaces. Following this, the general framework of normed spaces and Carathéodory's definition of the derivative are shown to simplify the statement and proof of various theorems in calculus and ordinary differential equations. The third and final part is devoted to interpolation, orthogonal polynomials, numerical integration, asymptotic expansions and the numerical solution of algebraic and differential equations. Students of both pure an...

  15. Knot topology in QCD

    CERN Document Server

    Zou, L P; Pak, D G

    2013-01-01

    We consider topological structure of classical vacuum solutions in quantum chromodynamics. Topologically non-equivalent vacuum configurations are classified by non-trivial second and third homotopy groups for coset of the color group SU(N) (N=2,3) under the action of maximal Abelian stability group. Starting with explicit vacuum knot configurations we study possible exact classical solutions as vacuum excitations. Exact analytic non-static knot solution in a simple CP^1 model in Euclidean space-time has been obtained. We construct an ansatz based on knot and monopole topological vacuum structure for searching new solutions in SU(2) and SU(3) QCD. We show that singular knot-like solutions in QCD in Minkowski space-time can be naturally obtained from knot solitons in integrable CP^1 models. A family of Skyrme type low energy effective theories of QCD admitting exact analytic solutions with non-vanishing Hopf charge is proposed.

  16. Topology optimized microbioreactors.

    Science.gov (United States)

    Schäpper, Daniel; Lencastre Fernandes, Rita; Lantz, Anna Eliasson; Okkels, Fridolin; Bruus, Henrik; Gernaey, Krist V

    2011-04-01

    This article presents the fusion of two hitherto unrelated fields--microbioreactors and topology optimization. The basis for this study is a rectangular microbioreactor with homogeneously distributed immobilized brewers yeast cells (Saccharomyces cerevisiae) that produce a recombinant protein. Topology optimization is then used to change the spatial distribution of cells in the reactor in order to optimize for maximal product flow out of the reactor. This distribution accounts for potentially negative effects of, for example, by-product inhibition. We show that the theoretical improvement in productivity is at least fivefold compared with the homogeneous reactor. The improvements obtained by applying topology optimization are largest where either nutrition is scarce or inhibition effects are pronounced.

  17. Riemann, topology, and physics

    CERN Document Server

    Monastyrsky, Michael I

    2008-01-01

    This significantly expanded second edition of Riemann, Topology, and Physics combines a fascinating account of the life and work of Bernhard Riemann with a lucid discussion of current interaction between topology and physics. The author, a distinguished mathematical physicist, takes into account his own research at the Riemann archives of Göttingen University and developments over the last decade that connect Riemann with numerous significant ideas and methods reflected throughout contemporary mathematics and physics. Special attention is paid in part one to results on the Riemann–Hilbert problem and, in part two, to discoveries in field theory and condensed matter such as the quantum Hall effect, quasicrystals, membranes with nontrivial topology, "fake" differential structures on 4-dimensional Euclidean space, new invariants of knots and more. In his relatively short lifetime, this great mathematician made outstanding contributions to nearly all branches of mathematics; today Riemann’s name appears prom...

  18. Algebraic topology and concurrency

    DEFF Research Database (Denmark)

    Fajstrup, Lisbeth; Raussen, Martin; Goubault, Eric

    2006-01-01

    We show in this article that some concepts from homotopy theory, in algebraic topology,are relevant for studying concurrent programs. We exhibit a natural semantics of semaphore programs, based on partially ordered topological spaces, which are studied up to “elastic deformation” or homotopy......, giving information about important properties of the program, such as deadlocks, unreachables, serializability, essential schedules, etc. In fact, it is not quite ordinary homotopy that has to be used, but rather a “directed homotopy” that does not reverse the flow of time. We show some of the essential...... differences between ordinary and directed homotopy through examples. We also relate the topological view to a combinatorial view of concurrent programs closer to transition systems, through the notion of a cubical set. Finally we apply some of these concepts to the proof of the safeness of a two...

  19. A topology on inequalities

    Directory of Open Access Journals (Sweden)

    Anna Maria D'Aristotile

    2006-08-01

    Full Text Available We consider sets of inequalities in Real Analysis and construct a topology such that inequalities usually called "limit cases" of certain sequences of inequalities are in fact limits - in the precise topological sense - of such sequences. To show the generality of the results, several examples are given for the notions introduced, and three main examples are considered: Sequences of inequalities relating real numbers, sequences of classical Hardy's inequalities, and sequences of embedding inequalities for fractional Sobolev spaces. All examples are considered along with their limit cases, and it is shown how they can be considered as sequences of one "big" space of inequalities. As a byproduct, we show how an abstract process to derive inequalities among homogeneous operators can be a tool for proving inequalities. Finally, we give some tools to compute limits of sequences of inequalities in the topology introduced, and we exhibit new applications.

  20. The Topological Vertex

    CERN Document Server

    Aganagic, M; Marino, M; Vafa, C; Aganagic, Mina; Klemm, Albrecht; Marino, Marcos; Vafa, Cumrun

    2005-01-01

    We construct a cubic field theory which provides all genus amplitudes of the topological A-model for all non-compact Calabi-Yau toric threefolds. The topology of a given Feynman diagram encodes the topology of a fixed Calabi-Yau, with Schwinger parameters playing the role of Kahler classes of Calabi-Yau. We interpret this result as an operator computation of the amplitudes in the B-model mirror which is the Kodaira-Spencer quantum theory. The only degree of freedom of this theory is an unconventional chiral scalar on a Riemann surface. In this setup we identify the B-branes on the mirror Riemann surface as fermions related to the chiral boson by bosonization.

  1. Manufacturing tolerant topology optimization

    DEFF Research Database (Denmark)

    Sigmund, Ole

    2009-01-01

    In this paper we present an extension of the topology optimization method to include uncertainties during the fabrication of macro, micro and nano structures. More specifically, we consider devices that are manufactured using processes which may result in (uniformly) too thin (eroded) or too thick...... (dilated) structures compared to the intended topology. Examples are MEMS devices manufactured using etching processes, nano-devices manufactured using e-beam lithography or laser micro-machining and macro structures manufactured using milling processes. In the suggested robust topology optimization...... approach, under- and over-etching is modelled by image processing-based "erode" and "dilate" operators and the optimization problem is formulated as a worst case design problem. Applications of the method to the design of macro structures for minimum compliance and micro compliant mechanisms show...

  2. Reversible Logic Circuit Synthesis

    CERN Document Server

    Shende, V V; Markov, I L; Prasad, A K; Hayes, John P.; Markov, Igor L.; Prasad, Aditya K.; Shende, Vivek V.

    2002-01-01

    Reversible, or information-lossless, circuits have applications in digital signal processing, communication, computer graphics and cryptography. They are also a fundamental requirement for quantum computation. We investigate the synthesis of reversible circuits that employ a minimum number of gates and contain no redundant input-output line-pairs (temporary storage channels). We propose new constructions for reversible circuits composed of NOT, Controlled-NOT, and TOFFOLI gates (the CNT gate library) based on permutation theory. A new algorithm is given to synthesize optimal reversible circuits using an arbitrary gate library. We also describe much faster heuristic algorithms. We also pursue applications of the proposed techniques to the synthesis of quantum circuits.

  3. Exact Threshold Circuits

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Podolskii, Vladimir V.

    2010-01-01

    We initiate a systematic study of constant depth Boolean circuits built using exact threshold gates. We consider both unweighted and weighted exact threshold gates and introduce corresponding circuit classes. We next show that this gives a hierarchy of classes that seamlessly interleave with the ......We initiate a systematic study of constant depth Boolean circuits built using exact threshold gates. We consider both unweighted and weighted exact threshold gates and introduce corresponding circuit classes. We next show that this gives a hierarchy of classes that seamlessly interleave...... with the well-studied corresponding hierarchies defined using ordinary threshold gates. A major open problem in Boolean circuit complexity is to provide an explicit super-polynomial lower bound for depth two threshold circuits. We identify the class of depth two exact threshold circuits as a natural subclass...

  4. Feedback in analog circuits

    CERN Document Server

    Ochoa, Agustin

    2016-01-01

    This book describes a consistent and direct methodology to the analysis and design of analog circuits with particular application to circuits containing feedback. The analysis and design of circuits containing feedback is generally presented by either following a series of examples where each circuit is simplified through the use of insight or experience (someone else’s), or a complete nodal-matrix analysis generating lots of algebra. Neither of these approaches leads to gaining insight into the design process easily. The author develops a systematic approach to circuit analysis, the Driving Point Impedance and Signal Flow Graphs (DPI/SFG) method that does not require a-priori insight to the circuit being considered and results in factored analysis supporting the design function. This approach enables designers to account fully for loading and the bi-directional nature of elements both in the feedback path and in the amplifier itself, properties many times assumed negligible and ignored. Feedback circuits a...

  5. Locally minimal topological groups

    OpenAIRE

    Außenhofer, Lydia; Chasco, María Jesús; Dikranjan, Dikran; Domínguez, Xabier

    2009-01-01

    A Hausdorff topological group $(G,\\tau)$ is called locally minimal if there exists a neighborhood $U$ of 0 in $\\tau$ such that $U$ fails to be a neighborhood of zero in any Hausdorff group topology on $G$ which is strictly coarser than $\\tau.$ Examples of locally minimal groups are all subgroups of Banach-Lie groups, all locally compact groups and all minimal groups. Motivated by the fact that locally compact NSS groups are Lie groups, we study the connection between local minimality and the ...

  6. Entanglement and topological interfaces

    CERN Document Server

    Brehm, Enrico M; Jaud, Daniel; Schmidt-Colinet, Cornelius

    2015-01-01

    In this paper we consider entanglement entropies in two-dimensional conformal field theories in the presence of topological interfaces. Tracing over one side of the interface, the leading term of the entropy remains unchanged. The interface however adds a subleading contribution, which can be interpreted as a relative (Kullback-Leibler) entropy with respect to the situation with no defect inserted. Reinterpreting boundaries as topological interfaces of a chiral half of the full theory, we rederive the left/right entanglement entropy in analogy with the interface case. We discuss WZW models and toroidal bosonic theories as examples.

  7. Filters in topology optimization

    DEFF Research Database (Denmark)

    Bourdin, Blaise

    1999-01-01

    In this article, a modified (``filtered'') version of the minimum compliance topology optimization problem is studied. The direct dependence of the material properties on its pointwise density is replaced by a regularization of the density field using a convolution operator. In this setting...... it is possible to establish the existence of solutions. Moreover, convergence of an approximation by means of finite elements can be obtained. This is illustrated through some numerical experiments. The ``filtering'' technique is also shown to cope with two important numerical problems in topology optimization...

  8. Filters in topology optimization

    DEFF Research Database (Denmark)

    Bourdin, Blaise

    1999-01-01

    In this article, a modified (``filtered'') version of the minimum compliance topology optimization problem is studied. The direct dependence of the material properties on its pointwise density is replaced by a regularization of the density field using a convolution operator. In this setting...... it is possible to establish the existence of solutions. Moreover, convergence of an approximation by means of finite elements can be obtained. This is illustrated through some numerical experiments. The ``filtering'' technique is also shown to cope with two important numerical problems in topology optimization...

  9. Free topological vector spaces

    OpenAIRE

    Gabriyelyan, Saak S.; Morris, Sidney A.

    2016-01-01

    We define and study the free topological vector space $\\mathbb{V}(X)$ over a Tychonoff space $X$. We prove that $\\mathbb{V}(X)$ is a $k_\\omega$-space if and only if $X$ is a $k_\\omega$-space. If $X$ is infinite, then $\\mathbb{V}(X)$ contains a closed vector subspace which is topologically isomorphic to $\\mathbb{V}(\\mathbb{N})$. It is proved that if $X$ is a $k$-space, then $\\mathbb{V}(X)$ is locally convex if and only if $X$ is discrete and countable. If $X$ is a metrizable space it is shown ...

  10. Fuzzy Topological Systems

    CERN Document Server

    Syropoulos, Apostolos

    2011-01-01

    Dialectica categories are a very versatile categorical model of linear logic. These have been used to model many seemingly different things (e.g., Petri nets and Lambek's calculus). In this note, we expand our previous work on fuzzy petri nets to deal with fuzzy topological systems. One basic idea is to use as the dualizing object in the Dialectica categories construction, the unit real interval [0,1], which has all the properties of a {\\em lineale}. The second basic idea is to generalize Vickers's notion of a topological system.

  11. Topological De-Noising: Strengthening the Topological Signal

    OpenAIRE

    2009-01-01

    Topological methods, including persistent homology, are powerful tools for analysis of high-dimensional data sets but these methods rely almost exclusively on thresholding techniques. In noisy data sets, thresholding does not always allow for the recovery of topological information. We present an easy to implement, computationally efficient pre-processing algorithm to prepare noisy point cloud data sets for topological data analysis. The topological de-noising algorithm allows for the recover...

  12. Topological hierarchy matters — topological matters with superlattices of defects

    Science.gov (United States)

    He, Jing; Kou, Su-Peng

    2016-11-01

    Topological insulators/superconductors are new states of quantum matter with metallic edge/surface states. In this paper, we review the defects effect in these topological states and study new types of topological matters — topological hierarchy matters. We find that both topological defects (quantized vortices) and non topological defects (vacancies) can induce topological mid-gap states in the topological hierarchy matters after considering the superlattice of defects. These topological mid-gap states have nontrivial topological properties, including the nonzero Chern number and the gapless edge states. Effective tight-binding models are obtained to describe the topological mid-gap states in the topological hierarchy matters. Project supported by the National Basic Research Program of China (Grant Nos. 2011CB921803 and 2012CB921704), the National Natural Science Foundation of China (Grant Nos. 11174035, 11474025, 11404090, and 11674026), the Natural Science Foundation of Hebei Province, China (Grant No. A2015205189), the Hebei Education Department Natural Science Foundation, China (Grant No. QN2014022), and the Specialized Research Fund for the Doctoral Program of Higher Education, China.

  13. Order Topology and Bi-Scott Topology on a Poset

    Institute of Scientific and Technical Information of China (English)

    Bin ZHAO; Kai Yun WANG

    2011-01-01

    In this paper,some properties of order topology and bi-Scott topology on a poset are obtained.Order-convergence in posets is further studied.Especially,a sufficient and necessary condition for order-convergence to be topological is given for some kind of posets.

  14. Topology Optimization with Stress Constraints

    NARCIS (Netherlands)

    Verbart, A.

    2015-01-01

    This thesis contains contributions to the development of topology optimization techniques capable of handling stress constraints. The research that led to these contributions was motivated by the need for topology optimization techniques more suitable for industrial applications. Currently, topolo

  15. Topology optimization of viscoelastic rectifiers

    DEFF Research Database (Denmark)

    Jensen, Kristian Ejlebjærg; Szabo, Peter; Okkels, Fridolin

    2012-01-01

    An approach for the design of microfluidic viscoelastic rectifiers is presented based on a combination of a viscoelastic model and the method of topology optimization. This presumption free approach yields a material layout topologically different from experimentally realized rectifiers...

  16. Degree 3 Networks Topological Routing

    DEFF Research Database (Denmark)

    Gutierrez Lopez, Jose Manuel; Riaz, M. Tahir; Pedersen, Jens Myrup;

    2009-01-01

    Topological routing is a table free alternative to traditional routing methods. It is specially well suited for organized network interconnection schemes. Topological routing algorithms correspond to the type O(1), constant complexity, being very attractive for large scale networks. It has been...... proposed for many topologies and this work compares the algorithms for three degree three topologies using a more analytical approach than previous studies....

  17. Numerical approach of the quantum circuit theory

    Science.gov (United States)

    Silva, J. J. B.; Duarte-Filho, G. C.; Almeida, F. A. G.

    2017-03-01

    In this paper we develop a numerical method based on the quantum circuit theory to approach the coherent electronic transport in a network of quantum dots connected with arbitrary topology. The algorithm was employed in a circuit formed by quantum dots connected each other in a shape of a linear chain (associations in series), and of a ring (associations in series, and in parallel). For both systems we compute two current observables: conductance and shot noise power. We find an excellent agreement between our numerical results and the ones found in the literature. Moreover, we analyze the algorithm efficiency for a chain of quantum dots, where the mean processing time exhibits a linear dependence with the number of quantum dots in the array.

  18. Numerical approach of the quantum circuit theory

    Energy Technology Data Exchange (ETDEWEB)

    Silva, J.J.B., E-mail: jaedsonfisica@hotmail.com; Duarte-Filho, G.C.; Almeida, F.A.G.

    2017-03-15

    In this paper we develop a numerical method based on the quantum circuit theory to approach the coherent electronic transport in a network of quantum dots connected with arbitrary topology. The algorithm was employed in a circuit formed by quantum dots connected each other in a shape of a linear chain (associations in series), and of a ring (associations in series, and in parallel). For both systems we compute two current observables: conductance and shot noise power. We find an excellent agreement between our numerical results and the ones found in the literature. Moreover, we analyze the algorithm efficiency for a chain of quantum dots, where the mean processing time exhibits a linear dependence with the number of quantum dots in the array.

  19. Integrated Circuits for Analog Signal Processing

    CERN Document Server

    2013-01-01

      This book presents theory, design methods and novel applications for integrated circuits for analog signal processing.  The discussion covers a wide variety of active devices, active elements and amplifiers, working in voltage mode, current mode and mixed mode.  This includes voltage operational amplifiers, current operational amplifiers, operational transconductance amplifiers, operational transresistance amplifiers, current conveyors, current differencing transconductance amplifiers, etc.  Design methods and challenges posed by nanometer technology are discussed and applications described, including signal amplification, filtering, data acquisition systems such as neural recording, sensor conditioning such as biomedical implants, actuator conditioning, noise generators, oscillators, mixers, etc.   Presents analysis and synthesis methods to generate all circuit topologies from which the designer can select the best one for the desired application; Includes design guidelines for active devices/elements...

  20. Locally minimal topological groups

    CERN Document Server

    enhofer, Lydia Au\\ss; Dikranjan, Dikran; Domínguez, Xabier

    2009-01-01

    A Hausdorff topological group $(G,\\tau)$ is called locally minimal if there exists a neighborhood $U$ of 0 in $\\tau$ such that $U$ fails to be a neighborhood of zero in any Hausdorff group topology on $G$ which is strictly coarser than $\\tau.$ Examples of locally minimal groups are all subgroups of Banach-Lie groups, all locally compact groups and all minimal groups. Motivated by the fact that locally compact NSS groups are Lie groups, we study the connection between local minimality and the NSS property, establishing that under certain conditions, locally minimal NSS groups are metrizable. A symmetric subset of an abelian group containing zero is said to be a GTG set if it generates a group topology in an analogous way as convex and symmetric subsets are unit balls for pseudonorms on a vector space. We consider topological groups which have a neighborhood basis at zero consisting of GTG sets. Examples of these locally GTG groups are: locally pseudo--convex spaces, groups uniformly free from small subgroups (...

  1. Topological Quantum Entanglement

    Science.gov (United States)

    2014-02-19

    Landau level more generally. “Bulk-Edge Correspondence in 2+1-Dimensional Abelian Topological Phases”, Jennifer Cano, Meng Cheng, Michael Mulligan ...2012). arXiv:1103.2770 34. Effective Field Theory of Fractional Quantized Hall Nematics (M. Mulligan , C. Nayak, and S. Kachru), Phys. Rev. B 84

  2. Perturbative Topological Field Theory

    Science.gov (United States)

    Dijkgraaf, Robbert

    We give a review of the application of perturbative techniques to topological quantum field theories, in particular three-dimensional Chern-Simons-Witten theory and its various generalizations. To this end we give an introduction to graph homology and homotopy algebras and the work of Vassiliev and Kontsevich on perturbative knot invariants.

  3. Topology evolutions of silhouettes

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    We give the topology changing of the silhouette in 3D space while others study the projections in an image. Silhouettes play a crucial role in visualization, graphics and vision. This work focuses on the global behaviors of silhouettes, especially their topological evolutions, such as splitting, merging, appearing and disappearing. The dynamics of silhouettes are governed by the topology, the curvature of the surface, and the view point. In this paper, we work on a more theoretical level to give enumerative properties of the silhouette including: the integration of signed geodesic curvature along a silhouette is equal to the view cone angle; in elliptic regions, no silhouette can be contained in another one; in hyperbolic regions, ifa silhouette is homotopic to a point, then it has at least 4 cusps; finally, critical events can only happen when the view point is on the aspect surfaces (ruled surface of the asymptotic lines of parabolic points with surface itself). We also introduce a method to visualize the evolution of silhouettes, especially all the critical events where the topologies of the silhouettes change. The results have broad applications in computer vision for recognition, graphics for rendering and visualization.

  4. Manufacturing tolerant topology optimization

    Institute of Scientific and Technical Information of China (English)

    Ole Sigmund

    2009-01-01

    In this paper we present an extension of the topology optimization method to include uncertainties during the fabrication of macro, micro and nano structures. More specifically, we consider devices that are manufactured using processes which may result in (uniformly) too thin (eroded)or too thick (dilated) structures compared to the intended topology. Examples are MEMS devices manufactured using etching processes, nano-devices manufactured using e-beam lithography or laser micro-machining and macro structures manufactured using milling processes. In the suggested robust topology optimization approach, under- and over-etching is modelled by image processing-based "erode" and "dilate" operators and the optimization problem is formulated as a worst case design problem. Applications of the method to the design of macro structures for minimum compliance and micro compliant mechanisms show that the method provides manufacturing tolerant designs with little decrease in performance. As a positive side effect the robust design formulation also eliminates the longstanding problem of one-node connected hinges in compliant mechanism design using topology optimization.

  5. Topological Trigger Developments

    CERN Document Server

    Likhomanenko, Tatiana

    2015-01-01

    The main b-physics trigger algorithm used by the LHCb experiment is the so-called topological trigger. The topological trigger selects vertices which are a) detached from the primary proton-proton collision and b) compatible with coming from the decay of a b-hadron. In the LHC Run 1, this trigger utilized a custom boosted decision tree algorithm, selected an almost 100% pure sample of b-hadrons with a typical efficiency of 60-70%, and its output was used in about 60% of LHCb papers. This talk presents studies carried out to optimize the topological trigger for LHC Run 2. In particular, we have carried out a detailed comparison of various machine learning classifier algorithms, e.g., AdaBoost, MatrixNet and uBoost. The topological trigger algorithm is designed to select all "interesting" decays of b-hadrons, but cannot be trained on every such decay. Studies have therefore been performed to determine how to optimize the performance of the classification algorithm on decays not used in the training. These inclu...

  6. LHCb Topological Trigger Reoptimization

    CERN Document Server

    Likhomanenko, Tatiana; Khairullin, Egor; Rogozhnikov, Alex; Ustyuzhanin, Andrey; Williams, Michael

    2015-01-01

    The main b-physics trigger algorithm used by the LHCb experiment is the so-called topological trigger. The topological trigger selects vertices which are a) detached from the primary proton-proton collision and b) compatible with coming from the decay of a b-hadron. In the LHC Run 1, this trigger, which utilized a custom boosted decision tree algorithm, selected a nearly 100% pure sample of b-hadrons with a typical efficiency of 60-70%; its output was used in about 60% of LHCb papers. This talk presents studies carried out to optimize the topological trigger for LHC Run 2. In particular, we have carried out a detailed comparison of various machine learning classifier algorithms, e.g., AdaBoost, MatrixNet and neural networks. The topological trigger algorithm is designed to select all "interesting" decays of b-hadrons, but cannot be trained on every such decay. Studies have therefore been performed to determine how to optimize the performance of the classification algorithm on decays not used in the training. ...

  7. Topological Data Analysis

    OpenAIRE

    2016-01-01

    Topological Data Analysis (TDA) can broadly be described as a collection of data analysis methods that find structure in data. This includes: clustering, manifold estimation, nonlinear dimension reduction, mode estimation, ridge estimation and persistent homology. This paper reviews some of these methods.

  8. Rendering the Topological Spines

    Energy Technology Data Exchange (ETDEWEB)

    Nieves-Rivera, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-05-05

    Many tools to analyze and represent high dimensional data already exits yet most of them are not flexible, informative and intuitive enough to help the scientists make the corresponding analysis and predictions, understand the structure and complexity of scientific data, get a complete picture of it and explore a greater number of hypotheses. With this in mind, N-Dimensional Data Analysis and Visualization (ND²AV) is being developed to serve as an interactive visual analysis platform with the purpose of coupling together a number of these existing tools that range from statistics, machine learning, and data mining, with new techniques, in particular with new visualization approaches. My task is to create the rendering and implementation of a new concept called topological spines in order to extend ND²AV's scope. Other existing visualization tools create a representation preserving either the topological properties or the structural (geometric) ones because it is challenging to preserve them both simultaneously. Overcoming such challenge by creating a balance in between them, the topological spines are introduced as a new approach that aims to preserve them both. Its render using OpenGL and C++ and is currently being tested to further on be implemented on ND²AV. In this paper I will present what are the Topological Spines and how they are rendered.

  9. Mapping network motif tunability and robustness in the design of synthetic signaling circuits.

    Directory of Open Access Journals (Sweden)

    Sergio Iadevaia

    Full Text Available Cellular networks are highly dynamic in their function, yet evolutionarily conserved in their core network motifs or topologies. Understanding functional tunability and robustness of network motifs to small perturbations in function and structure is vital to our ability to synthesize controllable circuits. In establishing core sets of network motifs, we selected topologies that are overrepresented in mammalian networks, including the linear, feedback, feed-forward, and bifan circuits. Static and dynamic tunability of network motifs were defined as the motif ability to respectively attain steady-state or transient outputs in response to pre-defined input stimuli. Detailed computational analysis suggested that static tunability is insensitive to the circuit topology, since all of the motifs displayed similar ability to attain predefined steady-state outputs in response to constant inputs. Dynamic tunability, in contrast, was tightly dependent on circuit topology, with some motifs performing superiorly in achieving observed time-course outputs. Finally, we mapped dynamic tunability onto motif topologies to determine robustness of motif structures to changes in topology and identify design principles for the rational assembly of robust synthetic networks.

  10. Fuzzy Soft Compact Topological Spaces

    Directory of Open Access Journals (Sweden)

    Seema Mishra

    2016-01-01

    Full Text Available In this paper, we have studied compactness in fuzzy soft topological spaces which is a generalization of the corresponding concept by R. Lowen in the case of fuzzy topological spaces. Several basic desirable results have been established. In particular, we have proved the counterparts of Alexander’s subbase lemma and Tychonoff theorem for fuzzy soft topological spaces.

  11. Topological susceptibility from overlap fermion

    Institute of Scientific and Technical Information of China (English)

    应和平; 张剑波

    2003-01-01

    We numerically calculate the topological charge of the gauge configurations on a finite lattice by the fermionic method with overlap fermions. By using the lattice index theorem, we identify the index of the massless overlap fermion operator to the topological charge of the background gauge configuration. The resulting topological susceptibility X is in good agreement with the anticipation made by Witten and Veneziano.

  12. Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion.

    Science.gov (United States)

    Itakura, Yuki; Kohsaka, Hiroshi; Ohyama, Tomoko; Zlatic, Marta; Pulver, Stefan R; Nose, Akinao

    2015-01-01

    Rhythmic motor patterns underlying many types of locomotion are thought to be produced by central pattern generators (CPGs). Our knowledge of how CPG networks generate motor patterns in complex nervous systems remains incomplete, despite decades of work in a variety of model organisms. Substrate borne locomotion in Drosophila larvae is driven by waves of muscular contraction that propagate through multiple body segments. We use the motor circuitry underlying crawling in larval Drosophila as a model to try to understand how segmentally coordinated rhythmic motor patterns are generated. Whereas muscles, motoneurons and sensory neurons have been well investigated in this system, far less is known about the identities and function of interneurons. Our recent study identified a class of glutamatergic premotor interneurons, PMSIs (period-positive median segmental interneurons), that regulate the speed of locomotion. Here, we report on the identification of a distinct class of glutamatergic premotor interneurons called Glutamatergic Ventro-Lateral Interneurons (GVLIs). We used calcium imaging to search for interneurons that show rhythmic activity and identified GVLIs as interneurons showing wave-like activity during peristalsis. Paired GVLIs were present in each abdominal segment A1-A7 and locally extended an axon towards a dorsal neuropile region, where they formed GRASP-positive putative synaptic contacts with motoneurons. The interneurons expressed vesicular glutamate transporter (vGluT) and thus likely secrete glutamate, a neurotransmitter known to inhibit motoneurons. These anatomical results suggest that GVLIs are premotor interneurons that locally inhibit motoneurons in the same segment. Consistent with this, optogenetic activation of GVLIs with the red-shifted channelrhodopsin, CsChrimson ceased ongoing peristalsis in crawling larvae. Simultaneous calcium imaging of the activity of GVLIs and motoneurons showed that GVLIs' wave-like activity lagged behind that of

  13. Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion.

    Directory of Open Access Journals (Sweden)

    Yuki Itakura

    Full Text Available Rhythmic motor patterns underlying many types of locomotion are thought to be produced by central pattern generators (CPGs. Our knowledge of how CPG networks generate motor patterns in complex nervous systems remains incomplete, despite decades of work in a variety of model organisms. Substrate borne locomotion in Drosophila larvae is driven by waves of muscular contraction that propagate through multiple body segments. We use the motor circuitry underlying crawling in larval Drosophila as a model to try to understand how segmentally coordinated rhythmic motor patterns are generated. Whereas muscles, motoneurons and sensory neurons have been well investigated in this system, far less is known about the identities and function of interneurons. Our recent study identified a class of glutamatergic premotor interneurons, PMSIs (period-positive median segmental interneurons, that regulate the speed of locomotion. Here, we report on the identification of a distinct class of glutamatergic premotor interneurons called Glutamatergic Ventro-Lateral Interneurons (GVLIs. We used calcium imaging to search for interneurons that show rhythmic activity and identified GVLIs as interneurons showing wave-like activity during peristalsis. Paired GVLIs were present in each abdominal segment A1-A7 and locally extended an axon towards a dorsal neuropile region, where they formed GRASP-positive putative synaptic contacts with motoneurons. The interneurons expressed vesicular glutamate transporter (vGluT and thus likely secrete glutamate, a neurotransmitter known to inhibit motoneurons. These anatomical results suggest that GVLIs are premotor interneurons that locally inhibit motoneurons in the same segment. Consistent with this, optogenetic activation of GVLIs with the red-shifted channelrhodopsin, CsChrimson ceased ongoing peristalsis in crawling larvae. Simultaneous calcium imaging of the activity of GVLIs and motoneurons showed that GVLIs' wave-like activity lagged

  14. Computing the topological susceptibility from fixed topology QCD simulations

    CERN Document Server

    Dromard, Arthur; Cichy, Krzysztof; Wagner, Marc

    2016-01-01

    The topological susceptibility is an important quantity in QCD, which can be computed using lattice methods. However, at a fine lattice spacing, or when using high quality chirally symmetric quarks, algorithms which proceed in small update steps --- in particular the HMC algorithm --- tend to get stuck in a single topological sector. In such cases, the computation of the topological susceptibility is not straightforward. Here, we explore two methods to extract the topological susceptibility from lattice QCD simulations restricted to a single topological sector. The first method is based on the correlation function of the topological charge density, while the second method relies on measuring the topological charge within spacetime subvolumes. Numerical results for two-flavor QCD obtained by using both methods are presented.

  15. Computational modeling of stuttering caused by impairments in a basal ganglia thalamo-cortical circuit involved in syllable selection and initiation

    Science.gov (United States)

    Civier, Oren; Bullock, Daniel; Max, Ludo; Guenther, Frank H.

    2013-01-01

    A typical white-matter integrity and elevated dopamine levels have been reported for individuals who stutter. We investigated how such abnormalities may lead to speech dysfluencies due to their effects on a syllable-sequencing circuit that consists of basal ganglia (BG), thalamus, and left ventral premotor cortex (vPMC). “Neurally impaired” versions of the neurocomputational speech production model GODIVA were utilized to test two hypotheses: (1) that white-matter abnormalities disturb the circuit via corticostriatal projections carrying copies of executed motor commands, and (2) that dopaminergic abnormalities disturb the circuit via the striatum. Simulation results support both hypotheses: in both scenarios, the neural abnormalities delay readout of the next syllable’s motor program, leading to dysfluency. The results also account for brain imaging findings during dysfluent speech. It is concluded that each of the two abnormality types can cause stuttering moments, probably by affecting the same BG-thalamus-vPMC circuit. PMID:23872286

  16. Regenerative feedback resonant circuit

    Science.gov (United States)

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  17. Analog circuit design

    CERN Document Server

    Dobkin, Bob

    2012-01-01

    Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

  18. Parallelizing quantum circuit synthesis

    OpenAIRE

    Di Matteo, Olivia; Mosca, Michele

    2016-01-01

    Quantum circuit synthesis is the process in which an arbitrary unitary operation is decomposed into a sequence of gates from a universal set, typically one which a quantum computer can implement both efficiently and fault-tolerantly. As physical implementations of quantum computers improve, the need is growing for tools which can effectively synthesize components of the circuits and algorithms they will run. Existing algorithms for exact, multi-qubit circuit synthesis scale exponentially in t...

  19. Analog circuits cookbook

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

  20. Cortical Motor Circuits after Piano Training in Adulthood: Neurophysiologic Evidence.

    Directory of Open Access Journals (Sweden)

    Elise Houdayer

    Full Text Available The neuronal mechanisms involved in brain plasticity after skilled motor learning are not completely understood. We aimed to study the short-term effects of keyboard training in music-naive subjects on the motor/premotor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS. Twelve subjects (experimental group underwent, before and after a two week-piano training: (1 hand-motor function tests: Jamar, grip and nine-hole peg tests; (2 electroencephalography, evaluating the mu rhythm task-related desynchronization (TRD during keyboard performance; and (3 TMS, targeting bilateral abductor pollicis brevis (APB and abductor digiti minimi (ADM, to obtain duration and area of ipsilateral silent period (ISP during simultaneous tonic contraction of APB and ADM. Data were compared with 13 controls who underwent twice these measurements, in a two-week interval, without undergoing piano training. Every subject in the experimental group improved keyboard performance and left-hand nine-hole peg test scores. Pre-training, ISP durations were asymmetrical, left being longer than right. Post-training, right ISPAPB increased, leading to symmetrical ISPAPB. Mu TRD during motor performance became more focal and had a lesser amplitude than in pre-training, due to decreased activity over ventral premotor cortices. No such changes were evidenced in controls. We demonstrated that a 10-day piano-training was associated with balanced interhemispheric interactions both at rest and during motor activation. Piano training, in a short timeframe, may reshape local and inter-hemispheric motor cortical circuits.

  1. A novel dual-site transcranial magnetic stimulation paradigm to probe fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex

    DEFF Research Database (Denmark)

    Groppa, Sergiu; Werner-Petroll, Nicole; Münchau, Alexander

    2012-01-01

    The dorsal premotor cortex (PMd) plays an import role in action control, sensorimotor integration and motor recovery. Animal studies and human data have demonstrated direct connections between ipsilateral PMd and primary motor cortex hand area (M1(HAND)). In this study we adopted a multimodal app...

  2. A change in injured corticospinal tract originating from the premotor cortex to the primary motor cortex in a patient with intracerebral hemorrhage

    Institute of Scientific and Technical Information of China (English)

    Sang Seok Yeo; Sung Ho Jang

    2012-01-01

    Many studies have attempted to elucidate the motor recovery mechanism of stroke, but the majority of these studies focus on cerebral infarct and relatively little is known about the motor recovery mechanism of intracerebral hemorrhage. In this study, we report on a patient with intracerebral hemorrhage who displayed a change in injured corticospinal tract originating from the premotor cortex to the primary motor cortex on diffusion tensor imaging. An 86-year-old woman presented with complete paralysis of the right extremities following spontaneous intracerebral hemorrhage in the left frontoparietal cortex. The patient showed motor recovery, to the extent of being able to extend affected fingers against gravity and to walk independently on even ground at 5 months after onset. Diffusion tensor imaging showed that the left corticospinal tract originated from the premotor cortex at 1 month after intracerebral hemorrhage and from the left primary motor cortex and premotor cortex at 5 months after intracerebral hemorrhage. The change of injured corticospinal tract originating from the premotor cortex to the primary motor cortex suggests motor recovery of intracerebral hemorrhage.

  3. Electronic devices and circuits

    CERN Document Server

    Pridham, Gordon John

    1968-01-01

    Electronic Devices and Circuits, Volume 1 deals with the design and applications of electronic devices and circuits such as passive components, diodes, triodes and transistors, rectification and power supplies, amplifying circuits, electronic instruments, and oscillators. These topics are supported with introductory network theory and physics. This volume is comprised of nine chapters and begins by explaining the operation of resistive, inductive, and capacitive elements in direct and alternating current circuits. The theory for some of the expressions quoted in later chapters is presented. Th

  4. CMOS circuits manual

    CERN Document Server

    Marston, R M

    1995-01-01

    CMOS Circuits Manual is a user's guide for CMOS. The book emphasizes the practical aspects of CMOS and provides circuits, tables, and graphs to further relate the fundamentals with the applications. The text first discusses the basic principles and characteristics of the CMOS devices. The succeeding chapters detail the types of CMOS IC, including simple inverter, gate and logic ICs and circuits, and complex counters and decoders. The last chapter presents a miscellaneous collection of two dozen useful CMOS circuits. The book will be useful to researchers and professionals who employ CMOS circu

  5. Circuits and filters handbook

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    A bestseller in its first edition, The Circuits and Filters Handbook has been thoroughly updated to provide the most current, most comprehensive information available in both the classical and emerging fields of circuits and filters, both analog and digital. This edition contains 29 new chapters, with significant additions in the areas of computer-aided design, circuit simulation, VLSI circuits, design automation, and active and digital filters. It will undoubtedly take its place as the engineer's first choice in looking for solutions to problems encountered in the design, analysis, and behavi

  6. Timergenerator circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Timer/Generator Circuits Manual is an 11-chapter text that deals mainly with waveform generator techniques and circuits. Each chapter starts with an explanation of the basic principles of its subject followed by a wide range of practical circuit designs. This work presents a total of over 300 practical circuits, diagrams, and tables.Chapter 1 outlines the basic principles and the different types of generator. Chapters 2 to 9 deal with a specific type of waveform generator, including sine, square, triangular, sawtooth, and special waveform generators pulse. These chapters also include pulse gen

  7. Security electronics circuits manual

    CERN Document Server

    MARSTON, R M

    1998-01-01

    Security Electronics Circuits Manual is an invaluable guide for engineers and technicians in the security industry. It will also prove to be a useful guide for students and experimenters, as well as providing experienced amateurs and DIY enthusiasts with numerous ideas to protect their homes, businesses and properties.As with all Ray Marston's Circuits Manuals, the style is easy-to-read and non-mathematical, with the emphasis firmly on practical applications, circuits and design ideas. The ICs and other devices used in the practical circuits are modestly priced and readily available ty

  8. MOS integrated circuit design

    CERN Document Server

    Wolfendale, E

    2013-01-01

    MOS Integral Circuit Design aims to help in the design of integrated circuits, especially large-scale ones, using MOS Technology through teaching of techniques, practical applications, and examples. The book covers topics such as design equation and process parameters; MOS static and dynamic circuits; logic design techniques, system partitioning, and layout techniques. Also featured are computer aids such as logic simulation and mask layout, as well as examples on simple MOS design. The text is recommended for electrical engineers who would like to know how to use MOS for integral circuit desi

  9. Printed circuit board industry.

    Science.gov (United States)

    LaDou, Joseph

    2006-05-01

    The printed circuit board is the platform upon which microelectronic components such as semiconductor chips and capacitors are mounted. It provides the electrical interconnections between components and is found in virtually all electronics products. Once considered low technology, the printed circuit board is evolving into a high-technology product. Printed circuit board manufacturing is highly complicated, requiring large equipment investments and over 50 process steps. Many of the high-speed, miniaturized printed circuit boards are now manufactured in cleanrooms with the same health and safety problems posed by other microelectronics manufacturing. Asia produces three-fourths of the world's printed circuit boards. In Asian countries, glycol ethers are the major solvents used in the printed circuit board industry. Large quantities of hazardous chemicals such as formaldehyde, dimethylformamide, and lead are used by the printed circuit board industry. For decades, chemically intensive and often sloppy manufacturing processes exposed tens of thousands of workers to a large number of chemicals that are now known to be reproductive toxicants and carcinogens. The printed circuit board industry has exposed workers to high doses of toxic metals, solvents, acids, and photolithographic chemicals. Only recently has there been any serious effort to diminish the quantity of lead distributed worldwide by the printed circuit board industry. Billions of electronics products have been discarded in every region of the world. This paper summarizes recent regulatory and enforcement efforts.

  10. Undergraduate topology a working textbook

    CERN Document Server

    McCluskey, Aisling

    2014-01-01

    This textbook offers an accessible, modern introduction at undergraduate level to an area known variously as general topology, point-set topology or analytic topology with a particular focus on helping students to build theory for themselves. It is the result of several years of the authors' combined university teaching experience stimulated by sustained interest in advanced mathematical thinking and learning, alongside established research careers in analytic topology. Point-set topology is a discipline that needs relatively little background knowledge, but sufficient determination to grasp i

  11. Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    M. T. Tadaiesky

    2010-01-01

    Full Text Available A previous study from our laboratory revealed that moderate nigral dopaminergic degeneration caused emotional and cognitive deficits in rats, paralleling early signs of Parkinson's disease. Recent evidence suggests that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease. Here, we investigated whether antagonism of CB1 receptors would improve emotional and cognitive deficits in a rat model of premotor Parkinson's disease. Depression-like behavior and cognition were assessed with the forced swim test and the social recognition test, respectively. Confirming our previous study, rats injected with 6-hydroxydopamine in striatum presented emotional and cognitive alterations which were improved by acute injection of SR141716A. HPLC analysis of monoamine levels demonstrated alterations in the striatum and prefrontal cortex after SR141716A injection. These findings suggest a role for CB1 receptors in the early symptoms caused by degeneration of dopaminergic neurons in the striatum, as observed in Parkinson's disease.

  12. Design of synthetic biological logic circuits based on evolutionary algorithm.

    Science.gov (United States)

    Chuang, Chia-Hua; Lin, Chun-Liang; Chang, Yen-Chang; Jennawasin, Tanagorn; Chen, Po-Kuei

    2013-08-01

    The construction of an artificial biological logic circuit using systematic strategy is recognised as one of the most important topics for the development of synthetic biology. In this study, a real-structured genetic algorithm (RSGA), which combines general advantages of the traditional real genetic algorithm with those of the structured genetic algorithm, is proposed to deal with the biological logic circuit design problem. A general model with the cis-regulatory input function and appropriate promoter activity functions is proposed to synthesise a wide variety of fundamental logic gates such as NOT, Buffer, AND, OR, NAND, NOR and XOR. The results obtained can be extended to synthesise advanced combinational and sequential logic circuits by topologically distinct connections. The resulting optimal design of these logic gates and circuits are established via the RSGA. The in silico computer-based modelling technology has been verified showing its great advantages in the purpose.

  13. Improved Classical Simulation of Quantum Circuits Dominated by Clifford Gates.

    Science.gov (United States)

    Bravyi, Sergey; Gosset, David

    2016-06-24

    We present a new algorithm for classical simulation of quantum circuits over the Clifford+T gate set. The runtime of the algorithm is polynomial in the number of qubits and the number of Clifford gates in the circuit but exponential in the number of T gates. The exponential scaling is sufficiently mild that the algorithm can be used in practice to simulate medium-sized quantum circuits dominated by Clifford gates. The first demonstrations of fault-tolerant quantum circuits based on 2D topological codes are likely to be dominated by Clifford gates due to a high implementation cost associated with logical T gates. Thus our algorithm may serve as a verification tool for near-term quantum computers which cannot in practice be simulated by other means. To demonstrate the power of the new method, we performed a classical simulation of a hidden shift quantum algorithm with 40 qubits, a few hundred Clifford gates, and nearly 50 T gates.

  14. A novel circuit architecture for fourth subharmonie mixers

    Institute of Scientific and Technical Information of China (English)

    Yao Changfei; Xu Conghai; Zhou Ming; Luo Yunsheng

    2012-01-01

    A circuit topology for high-order subharmonic (SH) mixers is described.By phase cancellation of idle frequency components,the SH mixer circuit can eliminate the complicated design procedure of idle frequency circuits.Similarly,the SH mixer circuit can achieve a high port isolation by phase cancellation of the leakage LO,RF and idle frequency signals.Based on the high-order SH mixer architecture,a new Ka-band fourth SH mixer is analyzed and designed,it shows the lowest measured conversion loss of 8.3 dB at 38.4 GHz and the loss is lower than 10.3 dB in 34-39 GHz.Measured LO-IF,RF-LO,RF-IF port isolation are better than 30.7 dB,22.9dB and 46.5 dB,respectively.

  15. Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actions

    Science.gov (United States)

    Ward, Nick S.; Bestmann, Sven; Hartwigsen, Gesa; Weiss, Michael M.; Christensen, Lars O.D.; Frackowiak, Richard S.J.; Rothwell, John C.; Siebner, Hartwig R.

    2013-01-01

    Left rostral dorsal premotor cortex (rPMd) and supramarginal gyrus (SMG) have been implicated in the dynamic control of actions. In 12 right-handed healthy individuals we applied 30 minutes of low-frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) over left rPMd to investigate the involvement of left rPMd and SMG in the rapid adjustment of actions guided by visuospatial cues. After rTMS, subjects underwent functional magnetic resonance imaging while making spatially congruent button presses with right or left index finger in response to a left- or right-sided target. Subjects were asked to covertly prepare motor responses as indicated by a directional cue presented one second before the target. On 20% of trials the cue was invalid requiring subjects to re-adjust their motor plan according to the target location. Compared to sham rTMS, real rTMS increased the number of correct responses in invalidly cued trials. After real rTMS, task-related activity of the stimulated left rPMd showed increased task-related coupling with activity in ipsilateral SMG and adjacent anterior intraparietal area (AIP). Individuals who showed a stronger increase in left-hemispheric premotor-parietal connectivity also made fewer errors on invalidly cued trials after rTMS. The results suggest that rTMS over left rPMd improved the ability to dynamically adjust visuospatial response mapping by strengthening left-hemispheric connectivity between rPMd and the SMG-AIP region. These results support the notion that left rPMd and SMG-AIP contribute towards dynamic control of actions, and demonstrate that low-frequency rTMS can enhance functional coupling between task-relevant brain regions and improve some aspects of motor performance. PMID:20610756

  16. Recognition and imitation of pantomimed motor acts after unilateral parietal and premotor lesions: a perspective on apraxia.

    Science.gov (United States)

    Halsband, U; Schmitt, J; Weyers, M; Binkofski, F; Grützner, G; Freund, H J

    2001-01-01

    We compared gesture comprehension and imitation in patients with lesions in the left parietal lobe (LPAR, n=5) and premotor cortex/supplementary motor area (LPMA, n=8) in patients with damage to the right parietal lobe (RPAR, n=6) and right premotor/supplementary motor area (RPMA, n=6) and in 16 non-brain damaged control subjects. Three patients with left parietal lobe damage had aphasia. Subjects were shown 136 meaningful pantomimed motor acts on a videoscreen and were asked to identify the movements and to imitate the motor acts from memory with their ipsilesional and contralesional hand or with both hands simultaneously. Motor tasks included gestures without object use (e.g. to salute, to wave) pantomimed imitation of gestures on one's own body (e.g. to comb one's hair) and pantomimed imitation of motor acts which imply tool use to an object in extrapersonal space (e.g. to hammer a nail). Videotaped test performance was analysed by two independent raters; errors were classified as spatial errors, body part as object, parapraxic performance and non-identifiable movements. In addition, action discrimination was tested by evaluating whether a complex motor sequence was correctly performed. Results indicate that LPAR patients were most severely disturbed when imitation performance was assessed. Interestingly, LPAR patients were worse when imitating gestures on their own bodies than imitating movements with reference to an external object use with most pronounced deficits in the spatial domain. In contrast to imitation, comprehension was not or only slightly disturbed and no clear correlation was found between the severity of imitation deficits and gesture comprehension. Moreover, although the three patients with aphasia imitated the movements more poorly than non-aphasic LPAR patients, the severity of comprehension errors did not differ. Whereas unimanual imitating performance and gesture comprehension of PMA patients did not differ significantly from control

  17. Testing the Role of Dorsal Premotor Cortex in Auditory-Motor Association Learning Using Transcranical Magnetic Stimulation (TMS)

    Science.gov (United States)

    Lega, Carlotta; Stephan, Marianne A.; Zatorre, Robert J.; Penhune, Virginia

    2016-01-01

    Interactions between the auditory and the motor systems are critical in music as well as in other domains, such as speech. The premotor cortex, specifically the dorsal premotor cortex (dPMC), seems to play a key role in auditory-motor integration, and in mapping the association between a sound and the movement used to produce it. In the present studies we tested the causal role of the dPMC in learning and applying auditory-motor associations using 1 Hz repetitive Transcranical Magnetic Stimulation (rTMS). In this paradigm, non-musicians learn a set of auditory-motor associations through melody training in two contexts: first when the sound to key-press mapping was in a conventional sequential order (low to high tones mapped onto keys from left to right), and then when it was in a novel scrambled order. Participant’s ability to match the four pitches to four computer keys was tested before and after the training. In both experiments, the group that received 1 Hz rTMS over the dPMC showed no significant improvement on the pitch-matching task following training, whereas the control group (who received rTMS to visual cortex) did. Moreover, in Experiment 2 where the pitch-key mapping was novel, rTMS over the dPMC also interfered with learning. These findings suggest that rTMS over dPMC disturbs the formation of auditory-motor associations, especially when the association is novel and must be learned rather explicitly. The present results contribute to a better understanding of the role of dPMC in auditory-motor integration, suggesting a critical role of dPMC in learning the link between an action and its associated sound. PMID:27684369

  18. The Topological Effects of Smoothing.

    Science.gov (United States)

    Shafii, S; Dillard, S E; Hlawitschka, M; Hamann, B

    2012-01-01

    Scientific data sets generated by numerical simulations or experimental measurements often contain a substantial amount of noise. Smoothing the data removes noise but can have potentially drastic effects on the qualitative nature of the data, thereby influencing its characterization and visualization via topological analysis, for example. We propose a method to track topological changes throughout the smoothing process. As a preprocessing step, we oversmooth the data and collect a list of topological events, specifically the creation and destruction of extremal points. During rendering, it is possible to select the number of topological events by interactively manipulating a merging parameter. The result that a specific amount of smoothing has on the topology of the data is illustrated using a topology-derived transfer function that relates region connectivity of the smoothed data to the original regions of the unsmoothed data. This approach enables visual as well as quantitative analysis of the topological effects of smoothing.

  19. Matching tutors and students: effective strategies for information transfer between circuits

    Science.gov (United States)

    Tesileanu, Tiberiu; Balasubramanian, Vijay; Olveczky, Bence

    Many neural circuits transfer learned information to downstream circuits: hippocampal-dependent memories are consolidated into long-term memories elsewhere; motor cortex is essential for skill learning but dispensable for execution; anterior forebrain pathway (AFP) in songbirds drives short-term improvements in song that are later consolidated in pre-motor area RA. We show how to match instructive signals from tutor circuits to synaptic plasticity rules in student circuits to achieve effective two-stage learning. We focus on learning sequential patterns where a timebase is transformed into motor commands by connectivity with a `student' area. If the sign of the synaptic change is given by the magnitude of tutor input, a good teaching strategy uses a strong (weak) tutor signal if student output is below (above) its target. If instead timing of tutor input relative to the timebase determines the sign of synaptic modifications, a good instructive signal accumulates the errors in student output as the motor program progresses. We demonstrate song learning in a biologically-plausible model of the songbird circuit given diverse plasticity rules interpolating between those described above. The model also reproduces qualitative firing statistics of RA neurons in juveniles and adults. Also affiliated to CUNY - Graduate Center.

  20. Individual premotor drive pulses, not time-varying synergies, are the units of adjustment for limb trajectories constructed in spinal cord.

    Science.gov (United States)

    Kargo, William J; Giszter, Simon F

    2008-03-05

    Complex actions may arise by combining simple motor primitives. Our studies support individual premotor drive pulses or bursts as execution primitives in spinal cord. Alternatively, the fundamental execution primitives at the segmental level could be time-varying synergies. To distinguish these hypotheses, we examined sensory feedback effects during targeted wiping organized in spinal cord. This behavior comprises three bursts. We tested (1) whether feedback altered the structure of individual premotor drive bursts or primitives, and (2) whether feedback differentially modulated different drive bursts or pulses in the three burst sequence. At least two of the three bursts would need to always be comodulated to support a time-varying synergy. We used selective muscle vibration to control spindle feedback from a single muscle (biceps/iliofibularis). The structures of premotor drive bursts were conserved. However, biceps vibration (1) scaled the amplitudes of two bursts coactivated during the initial phase of wiping independently of one another without altering their phase, and (2) independently phase regulated the third burst but preserved its amplitude. Thus, all three bursts were regulated separately. Durations were unaffected. The independent effects depended on (1) time of vibration during wiping, (2) frequency of vibration, and (3) limb configuration. Because each of the three bursts was independently modulated, these data strongly support execution using individual premotor bursts rather than time-varying synergies at the spinal level of motor organization. Our data show that both sensory feedback and central systems of the spinal cord act in concert to adjust the individual premotor bursts in support of the straight and unimodal wiping trajectory.

  1. Advanced Pulse Width Technique in Impedance Source Cascaded Multilevel Inverter with Asymmetric Topology

    Directory of Open Access Journals (Sweden)

    Rajnish Kumar Sharma

    2016-08-01

    Full Text Available In this research, a single phase Z-source cascading Multilevel Inverter, Nine-level inverter topologies with a trinary DC sources are offered. The recommended topologies are expanded by cascading a full bridge inverter with dissimilar DC sources. This paper recommends advanced pulse with modulation technique as a switching scheme. In this PWM technology, trapezoidal modulation technique is used as variable amplitude pulse width modulation. These topologies compromise reduced harmonics present in the output voltage and superior root mean square (RMS values of the output voltages linked with the traditional trapezoidal pulse width modulation. The simulation of proposed circuit is carried out by using MATLAB/SIMULINK.

  2. Design as Topology

    DEFF Research Database (Denmark)

    Ekman, Ulrik

    2015-01-01

    This article discusses the issue of approaching the design of the ubiquitous city as a matter of topology. The general context here is the design of contemporary global urbanity in the form of u-cities, smart cities, or intelligent cities emerging with the second phase of network societies...... that increasingly develop mixed reality environments with context-aware out-of-the-box computing as well as the soci-ocultural and experiental horizon of a virtually and physically mobile citizenry. Design here must meet an ongoing and exceedingly complex interactivity among environmental, technical, social...... and personal multiplicities of urban nodes on the move. This chapter focuses on the design of a busy traffic intersection in the South Korean u-city Songdo. Hence, the discussion whether and how Songdo may be approached via design as topology primarily considers the situation, event, and experience in which...

  3. DNA topology and transcription

    Science.gov (United States)

    Kouzine, Fedor; Levens, David; Baranello, Laura

    2014-01-01

    Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems. In this superstructure, DNA is the subject of mechanical forces applied by variety of molecular motors. Rather than being a rigid stick, DNA possesses dynamic structural variability that could be harnessed during critical steps of genome functioning. The strong relationship between DNA structure and key genomic processes necessitates the study of physical constrains acting on the double helix. Here we provide insight into the source, dynamics, and biology of DNA topological domains in the eukaryotic cells and summarize their possible involvement in gene transcription. We emphasize recent studies that might inspire and impact future experiments on the involvement of DNA topology in cellular functions. PMID:24755522

  4. Entanglement and topological interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Brehm, E.; Brunner, I.; Jaud, D.; Schmidt-Colinet, C. [Arnold Sommerfeld Center, Ludwig-Maximilians-Universitaet, Theresienstrasse 37, 80333, Muenchen (Germany)

    2016-06-15

    In this paper we consider entanglement entropies in two-dimensional conformal field theories in the presence of topological interfaces. Tracing over one side of the interface, the leading term of the entropy remains unchanged. The interface however adds a subleading contribution, which can be interpreted as a relative (Kullback-Leibler) entropy with respect to the situation with no defect inserted. Reinterpreting boundaries as topological interfaces of a chiral half of the full theory, we rederive the left/right entanglement entropy in analogy with the interface case. We discuss WZW models and toroidal bosonic theories as examples. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  5. DNA topology and transcription.

    Science.gov (United States)

    Kouzine, Fedor; Levens, David; Baranello, Laura

    2014-01-01

    Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems. In this superstructure, DNA is the subject of mechanical forces applied by variety of molecular motors. Rather than being a rigid stick, DNA possesses dynamic structural variability that could be harnessed during critical steps of genome functioning. The strong relationship between DNA structure and key genomic processes necessitates the study of physical constrains acting on the double helix. Here we provide insight into the source, dynamics, and biology of DNA topological domains in the eukaryotic cells and summarize their possible involvement in gene transcription. We emphasize recent studies that might inspire and impact future experiments on the involvement of DNA topology in cellular functions.

  6. Topology in Molecular Biology

    CERN Document Server

    Monastyrsky, Michail Ilych

    2007-01-01

    The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form.

  7. Topological signal processing

    CERN Document Server

    Robinson, Michael

    2014-01-01

    Signal processing is the discipline of extracting information from collections of measurements. To be effective, the measurements must be organized and then filtered, detected, or transformed to expose the desired information.  Distortions caused by uncertainty, noise, and clutter degrade the performance of practical signal processing systems. In aggressively uncertain situations, the full truth about an underlying signal cannot be known.  This book develops the theory and practice of signal processing systems for these situations that extract useful, qualitative information using the mathematics of topology -- the study of spaces under continuous transformations.  Since the collection of continuous transformations is large and varied, tools which are topologically-motivated are automatically insensitive to substantial distortion. The target audience comprises practitioners as well as researchers, but the book may also be beneficial for graduate students.

  8. Topologies of climate change

    DEFF Research Database (Denmark)

    Blok, Anders

    2010-01-01

    Climate change is quickly becoming a ubiquitous socionatural reality, mediating extremes of sociospatial scale from the bodily to the planetary. Although environmentalism invites us to ‘think globally and act locally', the meaning of these scalar designations remains ambiguous. This paper explores...... the topological presuppositions of social theory in the context of global climate change, asking how carbon emissions ‘translate' into various sociomaterial forms. Staging a meeting between Tim Ingold's phenomenology of globes and spheres and the social topologies of actor-network theory (ANT), the paper advances...... a ‘relational-scalar' analytics of spatial practices, technoscience, and power. As technoscience gradually constructs a networked global climate, this ‘grey box' comes to circulate within fluid social spaces, taking on new shades as it hybridizes knowledges, symbols, and practices. Global climates thus come...

  9. Network topology mapper

    Science.gov (United States)

    Quist, Daniel A.; Gavrilov, Eugene M.; Fisk, Michael E.

    2008-01-15

    A method enables the topology of an acyclic fully propagated network to be discovered. A list of switches that comprise the network is formed and the MAC address cache for each one of the switches is determined. For each pair of switches, from the MAC address caches the remaining switches that see the pair of switches are located. For each pair of switches the remaining switches are determined that see one of the pair of switches on a first port and the second one of the pair of switches on a second port. A list of insiders is formed for every pair of switches. It is determined whether the insider for each pair of switches is a graph edge and adjacent ones of the graph edges are determined. A symmetric adjacency matrix is formed from the graph edges to represent the topology of the data link network.

  10. Topological confinement and superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Al-hassanieh, Dhaled A [Los Alamos National Laboratory; Batista, Cristian D [Los Alamos National Laboratory

    2008-01-01

    We derive a Kondo Lattice model with a correlated conduction band from a two-band Hubbard Hamiltonian. This mapping allows us to describe the emergence of a robust pairing mechanism in a model that only contains repulsive interactions. The mechanism is due to topological confinement and results from the interplay between antiferromagnetism and delocalization. By using Density-Matrix-Renormalization-Group (DMRG) we demonstrate that this mechanism leads to dominant superconducting correlations in aID-system.

  11. Gods as Topological Invariants

    CERN Document Server

    Schoch, Daniel

    2012-01-01

    We show that the number of gods in a universe must equal the Euler characteristics of its underlying manifold. By incorporating the classical cosmological argument for creation, this result builds a bridge between theology and physics and makes theism a testable hypothesis. Theological implications are profound since the theorem gives us new insights in the topological structure of heavens and hells. Recent astronomical observations can not reject theism, but data are slightly in favor of atheism.

  12. Controlled algebra and topology

    OpenAIRE

    Pedersen, Erik K.

    1997-01-01

    Surgery and Geometric Topology : Proceedings of the conference held at Josai University 17-20 September, 1996 / edited by Andrew Ranicki and Masayuki Yamasaki. 本文データは許諾を得てeditorのHPサイトhttp://surgery.matrix.jp/math/josai96/proceedings.html から複製再利用したものである。

  13. Smooth Neutrosophic Topological Spaces

    Directory of Open Access Journals (Sweden)

    M. K. EL Gayyar

    2016-08-01

    Full Text Available As a new branch of philosophy, the neutrosophy was presented by Smarandache in 1980. It was presented as the study of origin, nature, and scope of neutralities; as well as their interactions with different ideational spectra. The aim in this paper is to introduce the concepts of smooth neutrosophic topological space, smooth neutrosophic cotopological space, smooth neutrosophic closure, and smooth neutrosophic interior. Furthermore, some properties of these concepts will be investigated.

  14. Smooth Neutrosophic Topological Spaces

    OpenAIRE

    M. K. EL GAYYAR

    2016-01-01

    As a new branch of philosophy, the neutrosophy was presented by Smarandache in 1980. It was presented as the study of origin, nature, and scope of neutralities; as well as their interactions with different ideational spectra. The aim in this paper is to introduce the concepts of smooth neutrosophic topological space, smooth neutrosophic cotopological space, smooth neutrosophic closure, and smooth neutrosophic interior. Furthermore, some properties of these concepts will be investigated.

  15. Computably regular topological spaces

    OpenAIRE

    Weihrauch, Klaus

    2013-01-01

    This article continues the study of computable elementary topology started by the author and T. Grubba in 2009 and extends the author's 2010 study of axioms of computable separation. Several computable T3- and Tychonoff separation axioms are introduced and their logical relation is investigated. A number of implications between these axioms are proved and several implications are excluded by counter examples, however, many questions have not yet been answered. Known results on computable metr...

  16. Energy efficient circuit design using nanoelectromechanical relays

    Science.gov (United States)

    Venkatasubramanian, Ramakrishnan

    Nano-electromechanical (NEM) relays are a promising class of emerging devices that offer zero off-state leakage and behave like an ideal switch. Recent advances in planar fabrication technology have demonstrated that microelectromechanical (MEMS) scale miniature relays could be manufactured reliably and could be used to build fully functional, complex integrated circuits. The zero leakage operation of relays has renewed the interest in relay based low power logic design. This dissertation explores circuit architectures using NEM relays and NEMS-CMOS heterogeneous integration. Novel circuit topologies for sequential logic, memory, and power management circuits have been proposed taking into consideration the NEM relay device properties and optimizing for energy efficiency and area. In nanoscale electromechanical devices, dispersion forces like Van der Waals' force (vdW) affect the pull-in stability of the relay devices significantly. Verilog-A electromechanical model of the suspended gate relay operating at 1V with a nominal air gap of 5 - 10nm has been developed taking into account all the electrical, mechanical and dispersion effects. This dissertation explores different relay based latch and flip-flop topologies. It has been shown that as few as 4 relay cells could be used to build flip-flops. An integrated voltage doubler based flip flop that improves the performance by 2X by overdriving Vgb has been proposed. Three NEM relay based parallel readout memory bitcell architectures have been proposed that have faster access time, and remove the reliability issues associated with previously reported serial readout architectures. A paradigm shift in design of power switches using NEM relays is proposed. An interesting property of the relay device is that the ON state resistance (Ron) of the NEM relay switch is constant and is insensitive to the gate slew rate. This coupled with infinite OFF state resistance (Roff ) offers significant area and power advantages over CMOS

  17. Topological Substituent Descriptors

    Directory of Open Access Journals (Sweden)

    Mircea V. DIUDEA

    2002-12-01

    Full Text Available Motivation. Substituted 1,3,5-triazines are known as useful herbicidal substances. In view of reducing the cost of biological screening, computational methods are carried out for evaluating the biological activity of organic compounds. Often a class of bioactives differs only in the substituent attached to a basic skeleton. In such cases substituent descriptors will give the same prospecting results as in case of using the whole molecule description, but with significantly reduced computational time. Such descriptors are useful in describing steric effects involved in chemical reactions. Method. Molecular topology is the method used for substituent description and multi linear regression analysis as a statistical tool. Results. Novel topological descriptors, XLDS and Ws, based on the layer matrix of distance sums and walks in molecular graphs, respectively, are proposed for describing the topology of substituents linked on a chemical skeleton. They are tested for modeling the esterification reaction in the class of benzoic acids and herbicidal activity of 2-difluoromethylthio-4,6-bis(monoalkylamino-1,3,5-triazines. Conclusions. Ws substituent descriptor, based on walks in graph, satisfactorily describes the steric effect of alkyl substituents behaving in esterification reaction, with good correlations to the Taft and Charton steric parameters, respectively. Modeling the herbicidal activity of the seo of 1,3,5-triazines exceeded the models reported in literature, so far.

  18. Topology and Fermionic Condensate

    Science.gov (United States)

    Kulikov, I.; Pronin, P.

    The purpose of this paper is to investigate an influence of a space-time topology on the formation of fermionic condensate in the model with four-fermion interaction ()2. The value for the space-time with topology of R1 × R1 × S1 is found. Moreover a relation of the value of fermionic condensate to a periodic length is studied. In this connection the possibility of a relation of the topologic deposits to structure of hadrons is discussed.Translated AbstractTopologie und FermikondensatEs wird der Einfluß einer Raum-Zeittopologie auf die Bildung des Fermikondensats in einem Modell mit Vierfermionenwechselwirkung ()2 untersucht. Für eine Raum-Zeit mit der Topologie R1 × R2 × S1 werden die Parameter gegeben. Weiterhin wird die Relation der Größe des Fermikondensats zu einer periodischen Länge untersucht. In diesem Zusammenhang wird die Verbindung des topologischen Depots zur Struktur der Hadronen diskutiert.

  19. Synchronizing Hyperchaotic Circuits

    DEFF Research Database (Denmark)

    Tamasevicius, Arunas; Cenys, Antanas; Namajunas, Audrius

    1997-01-01

    Regarding possible applications to secure communications the technique of synchronizing hyperchaotic circuits with a single dynamical variable is discussed. Several specific examples including the fourth-order circuits with two positive Lyapunov exponents as well as the oscillator with a delay line...... characterized by multiple positive Lyapunov exponents are reviewd....

  20. Genetic circuit design automation.

    Science.gov (United States)

    Nielsen, Alec A K; Der, Bryan S; Shin, Jonghyeon; Vaidyanathan, Prashant; Paralanov, Vanya; Strychalski, Elizabeth A; Ross, David; Densmore, Douglas; Voigt, Christopher A

    2016-04-01

    Computation can be performed in living cells by DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We describe a design environment, Cello, in which a user writes Verilog code that is automatically transformed into a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. We used Cello to design 60 circuits forEscherichia coli(880,000 base pairs of DNA), for which each DNA sequence was built as predicted by the software with no additional tuning. Of these, 45 circuits performed correctly in every output state (up to 10 regulators and 55 parts), and across all circuits 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization.

  1. A Virtual Circuits Lab

    Science.gov (United States)

    Vick, Matthew E.

    2010-01-01

    The University of Colorado's Physics Education Technology (PhET) website offers free, high-quality simulations of many physics experiments that can be used in the classroom. The Circuit Construction Kit, for example, allows students to safely and constructively play with circuit components while learning the mathematics behind many circuit…

  2. Trade-offs in Specific CMOS RF Communication Circuits

    Institute of Scientific and Technical Information of China (English)

    李效龙; 田雨波

    2009-01-01

    The design trade-off in the front-end of the transceiver, such as LNA, mixer, local oscillator and PA, is concerned. The advantages and limitations of the circuit topologies and key parameters of the state-of-the-art CMOS transceiver building blocks are discussed in order to gain more insight about a specific block design. A normalized formula of the figures of merit for each building block is also proposed to evaluate the overall performance of various circuits for fair comparison.

  3. Transportation Network Topologies

    Science.gov (United States)

    Holmes, Bruce J.; Scott, John

    2004-01-01

    A discomforting reality has materialized on the transportation scene: our existing air and ground infrastructures will not scale to meet our nation's 21st century demands and expectations for mobility, commerce, safety, and security. The consequence of inaction is diminished quality of life and economic opportunity in the 21st century. Clearly, new thinking is required for transportation that can scale to meet to the realities of a networked, knowledge-based economy in which the value of time is a new coin of the realm. This paper proposes a framework, or topology, for thinking about the problem of scalability of the system of networks that comprise the aviation system. This framework highlights the role of integrated communication-navigation-surveillance systems in enabling scalability of future air transportation networks. Scalability, in this vein, is a goal of the recently formed Joint Planning and Development Office for the Next Generation Air Transportation System. New foundations for 21st thinking about air transportation are underpinned by several technological developments in the traditional aircraft disciplines as well as in communication, navigation, surveillance and information systems. Complexity science and modern network theory give rise to one of the technological developments of importance. Scale-free (i.e., scalable) networks represent a promising concept space for modeling airspace system architectures, and for assessing network performance in terms of scalability, efficiency, robustness, resilience, and other metrics. The paper offers an air transportation system topology as framework for transportation system innovation. Successful outcomes of innovation in air transportation could lay the foundations for new paradigms for aircraft and their operating capabilities, air transportation system architectures, and airspace architectures and procedural concepts. The topology proposed considers air transportation as a system of networks, within which

  4. Topological De-Noising: Strengthening the Topological Signal

    CERN Document Server

    Kloke, Jennifer

    2009-01-01

    Topological methods such as persistent homology are powerful tools for data analysis of high-dimensional data sets but these methods almost exclusively rely on thresholding techniques. However, in noisy data sets thesholding does not always allow for the recovery of topological information. We present a computationally-efficient algorithm to allow for topological data analysis on noisy high-dimensional point cloud data sets. In many cases, the algorithm returns data that has so few outliers that there is no need to threshold the data before performing topological analysis. We apply the algorithm to synthetically-generated noisy data sets and show the recovery of topological information which is impossible to obtain via thresholding. We also apply the algorithm to natural image data in $\\mathbb{R}^8$ and show a very clean recovery of topological information previously only available with significant amounts of thresholding. Finally, we discuss future directions for improving this algorithm using zig-zag persis...

  5. Magnetic resonance energy and topological resonance energy.

    Science.gov (United States)

    Aihara, Jun-Ichi

    2016-04-28

    Ring-current diamagnetism of a polycyclic π-system is closely associated with thermodynamic stability due to the individual circuits. Magnetic resonance energy (MRE), derived from the ring-current diamagnetic susceptibility, was explored in conjunction with graph-theoretically defined topological resonance energy (TRE). For many aromatic molecules, MRE is highly correlative with TRE with a correlation coefficient of 0.996. For all π-systems studied, MRE has the same sign as TRE. The only trouble with MRE may be that some antiaromatic and non-alternant species exhibit unusually large MRE-to-TRE ratios. This kind of difficulty can in principle be overcome by prior geometry-optimisation or by changing spin multiplicity. Apart from the semi-empirical resonance-theory resonance energy, MRE is considered as the first aromatic stabilisation energy (ASE) defined without referring to any hypothetical polyene reference.

  6. Approximate circuits for increased reliability

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-08-18

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  7. Approximate circuits for increased reliability

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-12-22

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  8. QCD as topologically ordered system

    CERN Document Server

    Zhitnitsky, Ariel R

    2013-01-01

    We argue that QCD belongs to a topologically ordered phase similar to many well-known condensed matter systems with a gap such as topological insulators or superconductors. Our arguments are based on analysis of the so-called ``deformed QCD" which is a weakly coupled gauge theory, but nevertheless preserves all crucial elements of strongly interacting QCD, including confinement, nontrivial $\\theta$ dependence, degeneracy of the topological sectors, etc. Specifically, we construct the so-called topological ``BF" action which reproduces the well known infrared features of the theory such as non-dispersive contribution to the topological susceptibility which can not be associated with any propagating degrees of freedom. Furthermore, we interpret the well known resolution of the celebrated $U(1)_A$ problem when would be $\\eta'$ Goldstone boson generates its mass as a result of mixing of the Goldstone field with a topological auxiliary field characterizing the system. We identify the non-propagating auxiliary topo...

  9. Topological structures in computer science

    Directory of Open Access Journals (Sweden)

    Efim Khalimsky

    1987-01-01

    Full Text Available Topologies of finite spaces and spaces with countably many points are investigated. It is proven, using the theory of ordered topological spaces, that any topology in connected ordered spaces, with finitely many points or in spaces similar to the set of all integers, is an interval-alternating topology. Integer and digital lines, arcs, and curves are considered. Topology of N-dimensional digital spaces is described. A digital analog of the intermediate value theorem is proven. The equivalence of connectedness and pathconnectedness in digital and integer spaces is also proven. It is shown here how methods of continuous mathematics, for example, topological methods, can be applied to objects, that used to be investigated only by methods of discrete mathematics. The significance of methods and ideas in digital image and picture processing, robotic vision, computer tomography and system's sciences presented here is well known.

  10. Infrared Topological Plasmons in Graphene

    Science.gov (United States)

    Jin, Dafei; Christensen, Thomas; Soljačić, Marin; Fang, Nicholas X.; Lu, Ling; Zhang, Xiang

    2017-06-01

    We propose a two-dimensional plasmonic platform—periodically patterned monolayer graphene—which hosts topological one-way edge states operable up to infrared frequencies. We classify the band topology of this plasmonic system under time-reversal-symmetry breaking induced by a static magnetic field. At finite doping, the system supports topologically nontrivial band gaps with mid-gap frequencies up to tens of terahertz. By the bulk-edge correspondence, these band gaps host topologically protected one-way edge plasmons, which are immune to backscattering from structural defects and subject only to intrinsic material and radiation loss. Our findings reveal a promising approach to engineer topologically robust chiral plasmonic devices and demonstrate a realistic example of high-frequency topological edge states.

  11. Topological X-Rays Revisited

    Science.gov (United States)

    Lynch, Mark

    2012-01-01

    We continue our study of topological X-rays begun in Lynch ["Topological X-rays and MRI's," iJMEST 33(3) (2002), pp. 389-392]. We modify our definition of a topological magnetic resonance imaging and give an affirmative answer to the question posed there: Can we identify a closed set in a box by defining X-rays to probe the interior and without…

  12. Topology and geometry for physicists

    CERN Document Server

    Nash, Charles

    2011-01-01

    Differential geometry and topology are essential tools for many theoretical physicists, particularly in the study of condensed matter physics, gravity, and particle physics. Written by physicists for physics students, this text introduces geometrical and topological methods in theoretical physics and applied mathematics. It assumes no detailed background in topology or geometry, and it emphasizes physical motivations, enabling students to apply the techniques to their physics formulas and research. ""Thoroughly recommended"" by The Physics Bulletin, this volume's physics applications range fr

  13. Intuitionistic supra fuzzy topological spaces

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, S.E. E-mail: sabbas73@yahoo.com

    2004-09-01

    In this paper, We introduce an intuitionistic supra fuzzy closure space and investigate the relationship between intuitionistic supra fuzzy topological spaces and intuitionistic supra fuzzy closure spaces. Moreover, we can obtain intuitionistic supra fuzzy topological space induced by an intuitionistic fuzzy bitopological space. We study the relationship between intuitionistic supra fuzzy closure space and the intuitionistic supra fuzzy topological space induced by an intuitionistic fuzzy bitopological space.

  14. Transport Experiments on Topological Insulators

    Science.gov (United States)

    2016-08-16

    UU UU UU 16-08-2016 15-Sep-2011 14-Oct-2014 Final Report: Transport Experiments on Topological Insulators The views, opinions and/or findings contained...Triangle Park, NC 27709-2211 Topological Insulators, Dirac Semimetals, Transport in magnetic field, High mobility REPORT DOCUMENTATION PAGE 11. SPONSOR...ABSTRACT Final Report: Transport Experiments on Topological Insulators Report Title The ARO-supported research focused on uncovering novel materials and

  15. Plasmonic Nanoguides and Circuits

    CERN Document Server

    Bozhevolnyi, Sergey

    2008-01-01

    Modern communication systems dealing with huge amounts of data at ever increasing speed try to utilize the best aspects of electronic and optical circuits. Electronic circuits are tiny but their operation speed is limited, whereas optical circuits are extremely fast but their sizes are limited by diffraction. Waveguide components utilizing surface plasmon (SP) modes were found to combine the huge optical bandwidth and compactness of electronics, and plasmonics thereby began to be considered as the next chip-scale technology. In this book, the authors concentrate on the SP waveguide configurati

  16. Optoelectronics circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Optoelectronics Circuits Manual covers the basic principles and characteristics of the best known types of optoelectronic devices, as well as the practical applications of many of these optoelectronic devices. The book describes LED display circuits and LED dot- and bar-graph circuits and discusses the applications of seven-segment displays, light-sensitive devices, optocouplers, and a variety of brightness control techniques. The text also tackles infrared light-beam alarms and multichannel remote control systems. The book provides practical user information and circuitry and illustrations.

  17. Circuit analysis with Multisim

    CERN Document Server

    Baez-Lopez, David

    2011-01-01

    This book is concerned with circuit simulation using National Instruments Multisim. It focuses on the use and comprehension of the working techniques for electrical and electronic circuit simulation. The first chapters are devoted to basic circuit analysis.It starts by describing in detail how to perform a DC analysis using only resistors and independent and controlled sources. Then, it introduces capacitors and inductors to make a transient analysis. In the case of transient analysis, it is possible to have an initial condition either in the capacitor voltage or in the inductor current, or bo

  18. Modern TTL circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Modern TTL Circuits Manual provides an introduction to the basic principles of Transistor-Transistor Logic (TTL). This book outlines the major features of the 74 series of integrated circuits (ICs) and introduces the various sub-groups of the TTL family.Organized into seven chapters, this book begins with an overview of the basics of digital ICs. This text then examines the symbology and mathematics of digital logic. Other chapters consider a variety of topics, including waveform generator circuitry, clocked flip-flop and counter circuits, special counter/dividers, registers, data latches, com

  19. Pragmatic circuits frequency domain

    CERN Document Server

    Eccles, William

    2006-01-01

    Pragmatic Circuits: Frequency Domain goes through the Laplace transform to get from the time domain to topics that include the s-plane, Bode diagrams, and the sinusoidal steady state. This second of three volumes ends with a-c power, which, although it is just a special case of the sinusoidal steady state, is an important topic with unique techniques and terminology. Pragmatic Circuits: Frequency Domain is focused on the frequency domain. In other words, time will no longer be the independent variable in our analysis. The two other volumes in the Pragmatic Circuits series include titles on DC

  20. Gallium Arsenide Domino Circuit

    Science.gov (United States)

    Yang, Long; Long, Stephen I.

    1990-01-01

    Advantages include reduced power and high speed. Experimental gallium arsenide field-effect-transistor (FET) domino circuit replicated in large numbers for use in dynamic-logic systems. Name of circuit denotes mode of operation, which logic signals propagate from each stage to next when successive stages operated at slightly staggered clock cycles, in manner reminiscent of dominoes falling in a row. Building block of domino circuit includes input, inverter, and level-shifting substages. Combinational logic executed in input substage. During low half of clock cycle, result of logic operation transmitted to following stage.

  1. Troubleshooting analog circuits

    CERN Document Server

    Pease, Robert A

    1991-01-01

    Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

  2. Monolithic microwave integrated circuits

    Science.gov (United States)

    Pucel, R. A.

    Monolithic microwave integrated circuits (MMICs), a new microwave technology which is expected to exert a profound influence on microwave circuit designs for future military systems as well as for the commercial and consumer markets, is discussed. The book contains an historical discussion followed by a comprehensive review presenting the current status in the field. The general topics of the volume are: design considerations, materials and processing considerations, monolithic circuit applications, and CAD, measurement, and packaging techniques. All phases of MMIC technology are covered, from design to testing.

  3. OPTIMAL NETWORK TOPOLOGY DESIGN

    Science.gov (United States)

    Yuen, J. H.

    1994-01-01

    This program was developed as part of a research study on the topology design and performance analysis for the Space Station Information System (SSIS) network. It uses an efficient algorithm to generate candidate network designs (consisting of subsets of the set of all network components) in increasing order of their total costs, and checks each design to see if it forms an acceptable network. This technique gives the true cost-optimal network, and is particularly useful when the network has many constraints and not too many components. It is intended that this new design technique consider all important performance measures explicitly and take into account the constraints due to various technical feasibilities. In the current program, technical constraints are taken care of by the user properly forming the starting set of candidate components (e.g. nonfeasible links are not included). As subsets are generated, they are tested to see if they form an acceptable network by checking that all requirements are satisfied. Thus the first acceptable subset encountered gives the cost-optimal topology satisfying all given constraints. The user must sort the set of "feasible" link elements in increasing order of their costs. The program prompts the user for the following information for each link: 1) cost, 2) connectivity (number of stations connected by the link), and 3) the stations connected by that link. Unless instructed to stop, the program generates all possible acceptable networks in increasing order of their total costs. The program is written only to generate topologies that are simply connected. Tests on reliability, delay, and other performance measures are discussed in the documentation, but have not been incorporated into the program. This program is written in PASCAL for interactive execution and has been implemented on an IBM PC series computer operating under PC DOS. The disk contains source code only. This program was developed in 1985.

  4. Topological strings in d < 1

    Science.gov (United States)

    Dijkgraaf, Robbert; Verlinde, Herman; Verlinde, Erik

    1991-03-01

    We calculate correlation functions in minimal topological field theories. These twisted versions of N = 2 minimal models have recently been proposed to describe d < 1 matrix models, once coupled to topological gravity. In our calculation we make use of the Landau-Ginzburg formulation of the N = 2 models, and we find a direct relation between the Landau-Ginzburg superpotential and the KdV differential operator. Using this correspondence we show that the minimal topological models are in perfect agreement with the matrix models as solved in terms of the KdV hierarchy. This proves the equivalence at tree-level of topological and ordinary string thoery in d < 1.

  5. Nutrition Modeling Through Nano Topology

    Directory of Open Access Journals (Sweden)

    M. Lellis Thivagar,

    2014-01-01

    Full Text Available Nutrition is the provision, to cells and organisms, of the materials necessary in the form of food to support life. Many common health problems can be prevented or alleviated with a healthy, balanced diet. The purpose of this paper is to apply topological reduction of attributes in set-valued ordered information systems in finding the key foods suitable for two age groups in order to be healthy. We have already introduced a new topology called nano topology. The tactic applied here is in terms of basis of nano topology.

  6. Differential topology of semimetals

    CERN Document Server

    Mathai, Varghese

    2016-01-01

    The subtle interplay between local and global charges for topological semimetals exactly parallels that for singular vector fields. Part of this story is the relationship between cohomological semimetal invariants, Euler structures, and ambiguities in the torsion of manifolds. Dually, semimetal invariants can be represented by Euler chains from which the surface Fermi arc connectivity can be deduced. These dual pictures, and the link to insulators, are organised using geometric exact sequences. We go beyond Dirac-type Hamiltonians and introduce new classes of semimetals whose local charges are subtle Atiyah-Dupont-Thomas invariants globally constrained by the Kervaire semicharacteristic, leading to the prediction of torsion Fermi arcs.

  7. Fermions as Topological Objects

    Directory of Open Access Journals (Sweden)

    Yershov V. N.

    2006-01-01

    Full Text Available A preon-based composite model of the fundamental fermions is discussed, in which the fermions are bound states of smaller entities — primitive charges (preons. The preon is regarded as a dislocation in a dual 3-dimensional manifold — a topological object with no properties, save its unit mass and unit charge. It is shown that the dualism of this manifold gives rise to a hierarchy of complex structures resembling by their properties three families of the fundamental fermions. Although just a scheme for building a model of elementary particles, this description yields a quantitative explanation of many observable particle properties, including their masses.

  8. Fermions as topological objects

    CERN Document Server

    Yershov, V N

    2002-01-01

    A conceptual preon-based model of fermions is discussed. The preon is regarded as a topological object with three degrees of freedom in a dual three-dimensional manifold. It is shown that properties of this manifold give rise to a set of preon structures, which resemble three families of fermions. The number of preons in each structure is easily associated with the mass of a fermion. Being just a kind of zero-approximation to a theory of particles and interactions below the quark scale, our model however predicts masses of fermions with an accuracy of about 0.0002% without using any experimental input parameters.

  9. Topological forms of information

    Energy Technology Data Exchange (ETDEWEB)

    Baudot, Pierre [Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, 04103 Leipzig (Germany); Bennequin, Daniel [Universite Paris Diderot-Paris 7, UFR de Mathematiques, Equipe Geometrie et Dynamique, Batiment Sophie Germain, 5 rue Thomas Mann, 75205 Paris Cedex 13 (France)

    2015-01-13

    We propose that entropy is a universal co-homological class in a theory associated to a family of observable quantities and a family of probability distributions. Three cases are presented: 1) classical probabilities and random variables; 2) quantum probabilities and observable operators; 3) dynamic probabilities and observation trees. This gives rise to a new kind of topology for information processes. We discuss briefly its application to complex data, in particular to the structures of information flows in biological systems. This short note summarizes results obtained during the last years by the authors. The proofs are not included, but the definitions and theorems are stated with precision.

  10. Algebraic Topology, Rational Homotopy

    CERN Document Server

    1988-01-01

    This proceedings volume centers on new developments in rational homotopy and on their influence on algebra and algebraic topology. Most of the papers are original research papers dealing with rational homotopy and tame homotopy, cyclic homology, Moore conjectures on the exponents of the homotopy groups of a finite CW-c-complex and homology of loop spaces. Of particular interest for specialists are papers on construction of the minimal model in tame theory and computation of the Lusternik-Schnirelmann category by means articles on Moore conjectures, on tame homotopy and on the properties of Poincaré series of loop spaces.

  11. Counting and Topological Order

    Institute of Scientific and Technical Information of China (English)

    陈阳军

    1997-01-01

    The counting method is a simple and efficient method for processing linear recursive datalog queries.Its time complexity is bounded by O(n,e)where n and e denote the numbers the numbers of nodes and edges,respectively,in the graph representing the input.relations.In this paper,the concepts of heritage appearance function and heritage selection function are introduced,and an evaluation algorithm based on the computation of such functions in topological order is developed .This new algorithm requires only linear time in the case of non-cyclic data.

  12. Topological defect lasers

    CERN Document Server

    Knitter, Sebastian; Xiong, Wen; Guy, Mikhael I; Solomon, Glenn S; Cao, Hui

    2014-01-01

    We demonstrate topological defect lasers in a GaAs membrane with embedded InAs quantum dots. By introducing a disclination to a square-lattice of elliptical air holes, we obtain spatially confined optical resonances with high quality factor. Such resonances support powerflow vortices, and lase upon optical excitation of quantum dots, embedded in the structure. The spatially inhomogeneous variation of the unit cell orientation adds another dimension to the control of a lasing mode, enabling the manipulation of its field pattern and energy flow landscape.

  13. Modern general topology

    CERN Document Server

    Nagata, J-I

    1985-01-01

    This classic work has been fundamentally revised to take account of recent developments in general topology. The first three chapters remain unchanged except for numerous minor corrections and additional exercises, but chapters IV-VII and the new chapter VIII cover the rapid changes that have occurred since 1968 when the first edition appeared.The reader will find many new topics in chapters IV-VIII, e.g. theory of Wallmann-Shanin's compactification, realcompact space, various generalizations of paracompactness, generalized metric spaces, Dugundji type extension theory, linearly ordered topolo

  14. Foundations of combinatorial topology

    CERN Document Server

    Pontryagin, L S

    2015-01-01

    Hailed by The Mathematical Gazette as ""an extremely valuable addition to the literature of algebraic topology,"" this concise but rigorous introductory treatment focuses on applications to dimension theory and fixed-point theorems. The lucid text examines complexes and their Betti groups, including Euclidean space, application to dimension theory, and decomposition into components; invariance of the Betti groups, with consideration of the cone construction and barycentric subdivisions of a complex; and continuous mappings and fixed points. Proofs are presented in a complete, careful, and eleg

  15. Topological Transformation during Normal Grain Growth

    Institute of Scientific and Technical Information of China (English)

    Chaogang LOU; Michael A.Player

    2004-01-01

    This paper investigates topological transformation during normal grain growth by carrying out a computer vertex simulation.Results show that topological correlation agrees with the models proposed by Blanc et al. and Weaire. Topological transformation occurs more often on grains with some topological classes instead of equal probability on each boundary. This can be qualitatively explained by topological correlation.

  16. Printed circuit for ATLAS

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    A printed circuit board made by scientists in the ATLAS collaboration for the transition radiaton tracker (TRT). This will read data produced when a high energy particle crosses the boundary between two materials with different electrical properties.

  17. Latching overcurrent circuit breaker

    Science.gov (United States)

    Moore, M. L.

    1970-01-01

    Circuit breaker consists of a preset current amplitude sensor, and a lamp-photo-resistor combination in a feedback arrangement which energizes a power switching relay. The ac input power is removed from the load at predetermined current amplitudes.

  18. High temperature circuit breaker

    Science.gov (United States)

    Edwards, R. N.; Travis, E. F.

    1970-01-01

    Alternating current circuit breaker is suitable for reliable long-term service at 1000 deg F in the vacuum conditions of outer space. Construction materials are resistant to nuclear radiation and vacuum welding. Service test conditions and results are given.

  19. Topological social choice

    CERN Document Server

    1997-01-01

    The origins of this volume can be traced back to a conference on "Ethics, Economic and Business" organized by Columbia Busi­ ness School in March of 1993, and held in the splendid facilities of Columbia's Casa Italiana. Preliminary versions of several of the papers were presented at that meeting. In July 1994 the Fields Institute of Mathematical Sciences sponsored a workshop on "Geometry, Topology and Markets": additional papers and more refined versions of the original papers were presented there. They were published in their present versions in Social Choice and Wel­ fare, volume 14, number 2, 1997. The common aim of these workshops and this volume is to crystallize research in an area which has emerged rapidly in the last fifteen years, the area of topological approaches to social choice and the theory of games. The area is attracting increasing interest from social choice theorists, game theorists, mathematical econ­ omists and mathematicians, yet there is no authoritative collection of papers in the a...

  20. Topological quantum memory

    CERN Document Server

    Dennis, E; Landahl, A; Preskill, J; Dennis, Eric; Kitaev, Alexei; Landahl, Andrew; Preskill, John

    2002-01-01

    We analyze surface codes, the topological quantum error-correcting codes introduced by Kitaev. In these codes, qubits are arranged in a two-dimensional array on a surface of nontrivial topology, and encoded quantum operations are associated with nontrivial homology cycles of the surface. We formulate protocols for error recovery, and study the efficacy of these protocols. An order-disorder phase transition occurs in this system at a nonzero critical value of the error rate; if the error rate is below the critical value (the accuracy threshold), encoded information can be protected arbitrarily well in the limit of a large code block. This phase transition can be accurately modeled by a three-dimensional Z_2 lattice gauge theory with quenched disorder. We estimate the accuracy threshold, assuming that all quantum gates are local, that qubits can be measured rapidly, and that polynomial-size classical computations can be executed instantaneously. We also devise a robust recovery procedure that does not require m...

  1. Topological Quantum Double

    Science.gov (United States)

    Bonneau, Philippe

    Following a preceding paper showing how the introduction of a t.v.s. topology on quantum groups led to a remarkable unification and rigidification of the different definitions, we adapt here, in the same way, the definition of quantum double. This topological double is dualizable and reflexive (even for infinite dimensional algebras). In a simple case we show, considering the double as the "zero class" of an extension theory, the uniqueness of the double structure as a quasi-Hopf algebra. A la suite d'un précédent article montrant comment l'introduction d'une topologie d'e.v.t. sur les groupes quantiques permet une unification et une rigidification remarquables des différentes définitions, on adapte ici de la même manière la définition du double quantique. Ce double topologique est alors dualisable et reflexif (même pour des algèbres de dimension infinie). Dans un cas simple on montre, en considérant le double comme la "classe zéro" d'une théorie d'extensions, l'unicité de cette structure comme algèbre quasi-Hopf.

  2. A natural topological insulator.

    Science.gov (United States)

    Gehring, P; Benia, H M; Weng, Y; Dinnebier, R; Ast, C R; Burghard, M; Kern, K

    2013-03-13

    The earth's crust and outer space are rich sources of technologically relevant materials which have found application in a wide range of fields. Well-established examples are diamond, one of the hardest known materials, or graphite as a suitable precursor of graphene. The ongoing drive to discover novel materials useful for (opto)electronic applications has recently drawn strong attention to topological insulators. Here, we report that Kawazulite, a mineral with the approximate composition Bi2(Te,Se)2(Se,S), represents a naturally occurring topological insulator whose electronic properties compete well with those of its synthetic counterparts. Kawazulite flakes with a thickness of a few tens of nanometers were prepared by mechanical exfoliation. They exhibit a low intrinsic bulk doping level and correspondingly a sizable mobility of surface state carriers of more than 1000 cm(2)/(V s) at low temperature. Based on these findings, further minerals which due to their minimized defect densities display even better electronic characteristics may be identified in the future.

  3. Topological Transitions in Metamaterials

    CERN Document Server

    Krishnamoorthy, Harish N S; Narimanov, Evgenii; Kretzschmar, Ilona; Menon, Vinod M

    2011-01-01

    The ideas of mathematical topology play an important role in many aspects of modern physics - from phase transitions to field theory to nonlinear dynamics (1, 2). An important example of this is the Lifshitz transition (3), where the transformation of the Fermi surface of a metal from a closed to an open geometry (due to e.g. external pressure) leads to a dramatic effect on the electron magneto-transport (4). Here, we present the optical equivalent of the Lifshitz transition in strongly anisotropic metamaterials. When one of the components of the dielectric permittivity tensor of such a composite changes sign, the corresponding iso-frequency surface transforms from an ellipsoid to a hyperboloid. Since the photonic density of states can be related to the volume enclosed by the iso-frequency surface (5), such a topological transition in a metamaterial leads to a dramatic change in the photonic density of states, with a resulting effect on every single physical parameter related to the metamaterial - from thermo...

  4. Overriding Faulty Circuit Breakers

    Science.gov (United States)

    Robbins, Richard L.; Pierson, Thomas E.

    1987-01-01

    Retainer keeps power on in emergency. Simple mechanical device attaches to failed aircraft-type push/pull circuit breaker to restore electrical power temporarily until breaker replaced. Device holds push/pull button in closed position; unnecessary for crewmember to hold button in position by continual finger pressure. Sleeve and plug hold button in, overriding mechanical failure in circuit breaker. Windows in sleeve show button position.

  5. Topology with applications topological spaces via near and far

    CERN Document Server

    Naimpally, Somashekhar A

    2013-01-01

    The principal aim of this book is to introduce topology and its many applications viewed within a framework that includes a consideration of compactness, completeness, continuity, filters, function spaces, grills, clusters and bunches, hyperspace topologies, initial and final structures, metric spaces, metrization, nets, proximal continuity, proximity spaces, separation axioms, and uniform spaces. This book provides a complete framework for the study of topology with a variety of applications in science and engineering that include camouflage filters, classification, digital image processing, forgery detection, Hausdorff raster spaces, image analysis, microscopy, paleontology, pattern recognition, population dynamics, stem cell biology, topological psychology, and visual merchandising. It is the first complete presentation on topology with applications considered in the context of proximity spaces, and the nearness and remoteness of sets of objects. A novel feature throughout this book is the use of near and...

  6. Algebraic topology of finite topological spaces and applications

    CERN Document Server

    Barmak, Jonathan A

    2011-01-01

    This volume deals with the theory of finite topological spaces and its relationship with the homotopy and simple homotopy theory of polyhedra. The interaction between their intrinsic combinatorial and topological structures makes finite spaces a useful tool for studying problems in Topology, Algebra and Geometry from a new perspective. In particular, the methods developed in this manuscript are used to study Quillen’s conjecture on the poset of p-subgroups of a finite group and the Andrews-Curtis conjecture on the 3-deformability of contractible two-dimensional complexes. This self-contained work constitutes the first detailed exposition on the algebraic topology of finite spaces. It is intended for topologists and combinatorialists, but it is also recommended for advanced undergraduate students and graduate students with a modest knowledge of Algebraic Topology.

  7. Chains of topological oscillators with instantons and calculable topological observables in topological quantum mechanics

    Science.gov (United States)

    Baulieu, L.; Toppan, Francesco

    2016-11-01

    We extend to a possibly infinite chain the conformally invariant mechanical system that was introduced earlier as a toy model for understanding the topological Yang-Mills theory. It gives a topological quantum model that has interesting and computable zero modes and topological invariants. It confirms the recent conjecture by several authors that supersymmetric quantum mechanics may provide useful tools for understanding robotic mechanical systems (Vitelli et al.) and condensed matter properties (Kane et al.), where trajectories are allowed or not by the conservation of topological indices. The absences of ground state and mass gaps are special features of such systems.

  8. Chains of topological oscillators with instantons and calculable topological observables in topological quantum mechanics

    Directory of Open Access Journals (Sweden)

    L. Baulieu

    2016-11-01

    Full Text Available We extend to a possibly infinite chain the conformally invariant mechanical system that was introduced earlier as a toy model for understanding the topological Yang–Mills theory. It gives a topological quantum model that has interesting and computable zero modes and topological invariants. It confirms the recent conjecture by several authors that supersymmetric quantum mechanics may provide useful tools for understanding robotic mechanical systems (Vitelli et al. and condensed matter properties (Kane et al., where trajectories are allowed or not by the conservation of topological indices. The absences of ground state and mass gaps are special features of such systems.

  9. Chains of topological oscillators with instantons and calculable topological observables in topological quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Baulieu, L., E-mail: baulieu@lpthe.jussieu.fr [LPTHE – Sorbonne Universités, UPMC, 4 Place Jussieu, 75 005 Paris (France); Toppan, Francesco [CBPF, Rio de Janeiro, Rua Dr. Xavier Sigaud 150, Urca, cep 22290-180 (RJ) (Brazil)

    2016-11-15

    We extend to a possibly infinite chain the conformally invariant mechanical system that was introduced earlier as a toy model for understanding the topological Yang–Mills theory. It gives a topological quantum model that has interesting and computable zero modes and topological invariants. It confirms the recent conjecture by several authors that supersymmetric quantum mechanics may provide useful tools for understanding robotic mechanical systems (Vitelli et al.) and condensed matter properties (Kane et al.), where trajectories are allowed or not by the conservation of topological indices. The absences of ground state and mass gaps are special features of such systems.

  10. Chains of topological oscillators with instantons and calculable topological observables in topological quantum mechanics

    CERN Document Server

    Baulieu, Laurent

    2016-01-01

    We extend to a possibly infinite chain the conformally invariant mechanical system that was introduced earlier as a toy model for understanding the topological Yang-Mills theory. It gives a topological quantum model that has interesting and computable zero modes and topological invariants. It confirms the recent conjecture by several authors that supersymmetric quantum mechanics may provide useful tools for understanding robotic mechanical systems (Vitelli et al.) and condensed matter properties (Kane et al.), where trajectories of effective models are allowed or not by the conservation of topological indices. The absences of ground state and mass gaps are special features of such systems.

  11. Device and Circuit Design Challenges in the Digital Subthreshold Region for Ultralow-Power Applications

    Directory of Open Access Journals (Sweden)

    Ramesh Vaddi

    2009-01-01

    Full Text Available In recent years, subthreshold operation has gained a lot of attention due to ultra low-power consumption in applications requiring low to medium performance. It has also been shown that by optimizing the device structure, power consumption of digital subthreshold logic can be further minimized while improving its performance. Therefore, subthreshold circuit design is very promising for future ultra low-energy sensor applications as well as high-performance parallel processing. This paper deals with various device and circuit design challenges associated with the state of the art in optimal digital subthreshold circuit design and reviews device design methodologies and circuit topologies for optimal digital subthreshold operation. This paper identifies the suitable candidates for subthreshold operation at device and circuit levels for optimal subthreshold circuit design and provides an effective roadmap for digital designers interested to work with ultra low-power applications.

  12. Equivalent Circuit for Half-Bridge MMC Dc Fault Current Contribution

    OpenAIRE

    Leterme, Willem; Beerten, Jef; Van Hertem, Dirk

    2016-01-01

    The modular multilevel converter (MMC) is currently the preferred converter topology for HVDC point-to-point links and the likely choice for future meshed HVDC grids. For breaker dimensioning or protection system design, thorough knowledge of the dc fault currents supplied by these converters is required. In this paper, the dc fault current supplied by the half-bridge MMC is analyzed and an equivalent circuit model is proposed. The proposed equivalent circuit has a low complexity and accurate...

  13. Heterogeneous photonic integrated circuits

    Science.gov (United States)

    Fang, Alexander W.; Fish, Gregory; Hall, Eric

    2012-01-01

    Photonic Integrated Circuits (PICs) have been dichotomized into circuits with high passive content (silica and silicon PLCs) and high active content (InP tunable lasers and transceivers) due to the trade-off in material characteristics used within these two classes. This has led to restrictions in the adoption of PICs to systems in which only one of the two classes of circuits are required to be made on a singular chip. Much work has been done to create convergence in these two classes by either engineering the materials to achieve the functionality of both device types on a single platform, or in epitaxial growth techniques to transfer one material to the next, but have yet to demonstrate performance equal to that of components fabricated in their native substrates. Advances in waferbonding techniques have led to a new class of heterogeneously integrated photonic circuits that allow for the concurrent use of active and passive materials within a photonic circuit, realizing components on a transferred substrate that have equivalent performance as their native substrate. In this talk, we review and compare advances made in heterogeneous integration along with demonstrations of components and circuits enabled by this technology.

  14. Inferring topologies via driving-based generalized synchronization of two-layer networks

    Science.gov (United States)

    Wang, Yingfei; Wu, Xiaoqun; Feng, Hui; Lu, Jun-an; Xu, Yuhua

    2016-05-01

    The interaction topology among the constituents of a complex network plays a crucial role in the network’s evolutionary mechanisms and functional behaviors. However, some network topologies are usually unknown or uncertain. Meanwhile, coupling delays are ubiquitous in various man-made and natural networks. Hence, it is necessary to gain knowledge of the whole or partial topology of a complex dynamical network by taking into consideration communication delay. In this paper, topology identification of complex dynamical networks is investigated via generalized synchronization of a two-layer network. Particularly, based on the LaSalle-type invariance principle of stochastic differential delay equations, an adaptive control technique is proposed by constructing an auxiliary layer and designing proper control input and updating laws so that the unknown topology can be recovered upon successful generalized synchronization. Numerical simulations are provided to illustrate the effectiveness of the proposed method. The technique provides a certain theoretical basis for topology inference of complex networks. In particular, when the considered network is composed of systems with high-dimension or complicated dynamics, a simpler response layer can be constructed, which is conducive to circuit design. Moreover, it is practical to take into consideration perturbations caused by control input. Finally, the method is applicable to infer topology of a subnetwork embedded within a complex system and locate hidden sources. We hope the results can provide basic insight into further research endeavors on understanding practical and economical topology inference of networks.

  15. Parkinson disease and sleep: sleep-wake changes in the premotor stage of Parkinson disease; impaired olfaction and other prodromal features.

    Science.gov (United States)

    Iranzo, Alex

    2013-09-01

    Parkinson disease (PD) has a premotor stage where neurodegeneration occurs before parkinsonism becomes apparent. Identification of individuals at this stage provides an opportunity to study early disease progression and test disease-modifying interventions. Hyposmia, constipation, depression and hypersomnia are part of this premotor phase and predictive of future development of PD. However, these features are common in the general population, and they are most often the result of causes other than incipient PD. In contrast, most individuals with idiopathic REM sleep behavior disorder (IRBD) eventually develop PD and other synucleinopathies. IRBD individuals with hyposmia, substantia nigra hyperechogenicity, and abnormal striatal dopamine transporter imaging findings have increased short-term risk of developing a synucleinopathy. IRBD is an optimal target to test disease-modifying agents in the PD prodromal phase. Serial dopamine transporter imaging, but not olfactory tests, may serve to monitor the disease process in future disease-modifying trials in IRBD.

  16. Resonant enhanced parallel-T topology for weak coupling wireless power transfer pickup applications

    Directory of Open Access Journals (Sweden)

    Yao Guo

    2015-07-01

    Full Text Available For the wireless power transfer (WPT system, the transfer performance and the coupling coefficient are contradictory. In this paper, a novel parallel-T resonant topology consists of a traditional parallel circuit and a T-matching network for secondary side is proposed. With this method, a boosted voltage can be output to the load, since this topology has a resonant enhancement effect, and high Q value can be obtained at a low resonant frequency and low coil inductance. This feature makes it more suitable for weak coupling WPT applications. Besides, the proposed topology shows good frequency stability and adaptability to variations of load. Experimental results show that the output voltage gain improves by 757% compared with traditional series circuit, and reaches 85% total efficiency when the coupling coefficient is 0.046.

  17. The birth of topological insulators.

    Science.gov (United States)

    Moore, Joel E

    2010-03-11

    Certain insulators have exotic metallic states on their surfaces. These states are formed by topological effects that also render the electrons travelling on such surfaces insensitive to scattering by impurities. Such topological insulators may provide new routes to generating novel phases and particles, possibly finding uses in technological applications in spintronics and quantum computing.

  18. Topological arguments for Kolmogorov complexity

    Directory of Open Access Journals (Sweden)

    Alexander Shen

    2012-08-01

    Full Text Available We present several application of simple topological arguments in problems of Kolmogorov complexity. Basically we use the standard fact from topology that the disk is simply connected. It proves to be enough to construct strings with some nontrivial algorithmic properties.

  19. Observational modeling of topological spaces

    Energy Technology Data Exchange (ETDEWEB)

    Molaei, M.R. [Department of Mathematics, Shahid Bahonar University of Kerman, Kerman 76169-14111 (Iran, Islamic Republic of)], E-mail: mrmolaei@mail.uk.ac.ir

    2009-10-15

    In this paper a model for a multi-dimensional observer by using of the fuzzy theory is presented. Relative form of Tychonoff theorem is proved. The notion of topological entropy is extended. The persistence of relative topological entropy under relative conjugate relation is proved.

  20. Solving equations by topological methods

    Directory of Open Access Journals (Sweden)

    Lech Górniewicz

    2005-01-01

    Full Text Available In this paper we survey most important results from topological fixed point theory which can be directly applied to differential equations. Some new formulations are presented. We believe that our article will be useful for analysts applying topological fixed point theory in nonlinear analysis and in differential equations.

  1. Topological Vortices in Superfluid Films

    Institute of Scientific and Technical Information of China (English)

    WANGJun-Ping; DUANYi-Shi

    2005-01-01

    We study the topological structure of the vortex system in a superfluid film. Explicit expressions for the vortex density and velocity field as functions of the superfluid order parameter are derived. The evolution of vortices is also studied from the topological properties of the superfluid order parameter field.

  2. Acoustic design by topology optimization

    DEFF Research Database (Denmark)

    Dühring, Maria Bayard; Jensen, Jakob Søndergaard; Sigmund, Ole

    2008-01-01

    To bring down noise levels in human surroundings is an important issue and a method to reduce noise by means of topology optimization is presented here. The acoustic field is modeled by Helmholtz equation and the topology optimization method is based on continuous material interpolation functions...

  3. High power density dc/dc converter: Selection of converter topology

    Science.gov (United States)

    Divan, Deepakraj M.

    1990-01-01

    The work involved in the identification and selection of a suitable converter topology is described. Three new dc/dc converter topologies are proposed: Phase-Shifted Single Active Bridge DC/DC Converter; Single Phase Dual Active Bridges DC/DC Converter; and Three Phase Dual Active Bridges DC/DC Converter (Topology C). The salient features of these topologies are: (1) All are minimal in structure, i.e., each consists of an input and output bridge, input and output filter and a transformer, all components essential for a high power dc/dc conversion process; (2) All devices of both the bridges can operate under near zero-voltage conditions, making possible a reduction of device switching losses and hence, an increase in switching frequency; (3) All circuits operate at a constant frequency, thus simplifying the task of the magnetic and filter elements; (4) Since, the leakage inductance of the transformer is used as the main current transfer element, problems associated with the diode reverse recovery are eliminated. Also, this mode of operation allows easy paralleling of multiple modules for extending the power capacity of the system; (5) All circuits are least sensitive to parasitic impedances, infact the parasitics are efficently utilized; and (6) The soft switching transitions, result in low electromagnetic interference. A detailed analysis of each topology was carried out. Based on the analysis, the various device and component ratings for each topology operating at an optimum point, and under the given specifications, are tabulated and discussed.

  4. An alternative low-loss stack topology for vanadium redox flow battery: Comparative assessment

    Science.gov (United States)

    Moro, Federico; Trovò, Andrea; Bortolin, Stefano; Del, Davide, , Col; Guarnieri, Massimo

    2017-02-01

    Two vanadium redox flow battery topologies have been compared. In the conventional series stack, bipolar plates connect cells electrically in series and hydraulically in parallel. The alternative topology consists of cells connected in parallel inside stacks by means of monopolar plates in order to reduce shunt currents along channels and manifolds. Channelled and flat current collectors interposed between cells were considered in both topologies. In order to compute the stack losses, an equivalent circuit model of a VRFB cell was built from a 2D FEM multiphysics numerical model based on Comsol®, accounting for coupled electrical, electrochemical, and charge and mass transport phenomena. Shunt currents were computed inside the cells with 3D FEM models and in the piping and manifolds by means of equivalent circuits solved with Matlab®. Hydraulic losses were computed with analytical models in piping and manifolds and with 3D numerical analyses based on ANSYS Fluent® in the cell porous electrodes. Total losses in the alternative topology resulted one order of magnitude lower than in an equivalent conventional battery. The alternative topology with channelled current collectors exhibits the lowest shunt currents and hydraulic losses, with round-trip efficiency higher by about 10%, as compared to the conventional topology.

  5. An analytical approach to bistable biological circuit discrimination using real algebraic geometry.

    Science.gov (United States)

    Siegal-Gaskins, Dan; Franco, Elisa; Zhou, Tiffany; Murray, Richard M

    2015-07-06

    Biomolecular circuits with two distinct and stable steady states have been identified as essential components in a wide range of biological networks, with a variety of mechanisms and topologies giving rise to their important bistable property. Understanding the differences between circuit implementations is an important question, particularly for the synthetic biologist faced with determining which bistable circuit design out of many is best for their specific application. In this work we explore the applicability of Sturm's theorem--a tool from nineteenth-century real algebraic geometry--to comparing 'functionally equivalent' bistable circuits without the need for numerical simulation. We first consider two genetic toggle variants and two different positive feedback circuits, and show how specific topological properties present in each type of circuit can serve to increase the size of the regions of parameter space in which they function as switches. We then demonstrate that a single competitive monomeric activator added to a purely monomeric (and otherwise monostable) mutual repressor circuit is sufficient for bistability. Finally, we compare our approach with the Routh-Hurwitz method and derive consistent, yet more powerful, parametric conditions. The predictive power and ease of use of Sturm's theorem demonstrated in this work suggest that algebraic geometric techniques may be underused in biomolecular circuit analysis.

  6. Extroversion-related differences in speed of premotor and motor processing as revealed by lateralized readiness potentials.

    Science.gov (United States)

    Stahl, Jutta; Rammsayer, Thomas

    2008-03-01

    To further elucidate extroversion-related differences in speed of sensorimotor processing, the authors obtained behavioral and psychophysiological measures as participants (16 introverts and 16 extroverts) performed a visual go/no-go task. Although no extroversion-related differences in reaction time emerged, introverts showed faster premotor processing but slower central and peripheral motor processing--as indicated by latencies of the lateralized readiness potential (LRP) and electromyographic (EMG) data, respectively--than extroverts did. Additional regression analyses revealed that stimulus-locked LRP latency, response-locked LRP latency, and Nl EMG amplitude accounted for 40% of overall variability in individual extroversion scores. On the basis of the present results, the authors introduce a compensation hypothesis that accounts for the common failure of researchers to demonstrate extroversion-related differences in reaction time. The present results challenge J. Brebner and C. Cooper's (1985) model of extroversion in which stimulus analysis is not slower in introverts than in extroverts. However, the present findings support the assumption of faster motor processing in extroverts.

  7. View-based encoding of actions in mirror neurons of area f5 in macaque premotor cortex.

    Science.gov (United States)

    Caggiano, Vittorio; Fogassi, Leonardo; Rizzolatti, Giacomo; Pomper, Joern K; Thier, Peter; Giese, Martin A; Casile, Antonino

    2011-01-25

    Converging experimental evidence indicates that mirror neurons in the monkey premotor area F5 encode the goals of observed motor acts [1-3]. However, it is unknown whether they also contribute to encoding the perspective from which the motor acts of others are seen. In order to address this issue, we recorded the visual responses of mirror neurons of monkey area F5 by using a novel experimental paradigm based on the presentation of movies showing grasping motor acts from different visual perspectives. We found that the majority of the tested mirror neurons (74%) exhibited view-dependent activity with responses tuned to specific points of view. A minority of the tested mirror neurons (26%) exhibited view-independent responses. We conclude that view-independent mirror neurons encode action goals irrespective of the details of the observed motor acts, whereas the view-dependent ones might either form an intermediate step in the formation of view independence or contribute to a modulation of view-dependent representations in higher-level visual areas, potentially linking the goals of observed motor acts with their pictorial aspects. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Contribution of writing to reading: Dissociation between cognitive and motor process in the left dorsal premotor cortex.

    Science.gov (United States)

    Pattamadilok, Chotiga; Ponz, Aurélie; Planton, Samuel; Bonnard, Mireille

    2016-04-01

    Functional brain imaging studies reported activation of the left dorsal premotor cortex (PMd), that is, a main area in the writing network, in reading tasks. However, it remains unclear whether this area is causally relevant for written stimulus recognition or its activation simply results from a passive coactivation of reading and writing networks. Here, we used chronometric paired-pulse transcranial magnetic stimulation (TMS) to address this issue by disrupting the activity of the PMd, the so-called Exner's area, while participants performed a lexical decision task. Both words and pseudowords were presented in printed and handwritten characters. The latter was assumed to be closely associated with motor representations of handwriting gestures. We found that TMS over the PMd in relatively early time-windows, i.e., between 60 and 160 ms after the stimulus onset, increased reaction times to pseudoword without affecting word recognition. Interestingly, this result pattern was found for both printed and handwritten characters, that is, regardless of whether the characters evoked motor representations of writing actions. Our result showed that under some circumstances the activation of the PMd does not simply result from passive association between reading and writing networks but has a functional role in the reading process. At least, at an early stage of written stimuli recognition, this role seems to depend on a common sublexical and serial process underlying writing and pseudoword reading rather than on an implicit evocation of writing actions during reading as typically assumed.

  9. Single-cell coding of sensory, spatial and numerical magnitudes in primate prefrontal, premotor and cingulate motor cortices.

    Science.gov (United States)

    Eiselt, Anne-Kathrin; Nieder, Andreas

    2016-01-01

    The representation of magnitude information enables humans and animal species alike to successfully interact with the external environment. However, how various types of magnitudes are processed by single neurons to guide goal-directed behavior remains elusive. Here, we recorded single-cell activity from the dorsolateral prefrontal (PFC), dorsal premotor (PMd) and cingulate motor (CMA) cortices in monkeys discriminating discrete numerical (numerosity), continuous spatial (line length) and basic sensory (spatial frequency) stimuli. We found that almost exclusively PFC neurons represented the different magnitude types during sample presentation and working memory periods. The frequency of magnitude-selective cells in PMd and CMA did not exceed chance level. The proportion of PFC neurons selectively tuned to each of the three magnitude types were comparable. Magnitude coding was mainly dissociated at the single-neuron level, with individual neurons representing only one of the three tested magnitude types. Neuronal magnitude discriminability, coding strength and temporal evolution were comparable between magnitude types encoded by PFC neuron populations. Our data highlight the importance of PFC neurons in representing various magnitude categories. Such magnitude representations are based on largely distributed coding by single neurons that are anatomically intermingled within the same cortical area.

  10. Prefrontal and agranular cingulate projections to the dorsal premotor areas F2 and F7 in the macaque monkey.

    Science.gov (United States)

    Luppino, Giuseppe; Rozzi, Stefano; Calzavara, Roberta; Matelli, Massimo

    2003-02-01

    The superior sector of Brodmann area 6 (dorsal premotor cortex, PMd) of the macaque monkey consists of a rostral and a caudal architectonic area referred to as F7 and F2, respectively. The aim of this study was to define the origin of prefrontal and agranular cingulate afferents to F7 and F2, in the light of functional and hodological evidence showing that these areas do not appear to be functionally homogeneous. Different sectors of F7 and F2 were injected with neural tracers in seven monkeys and the retrograde labelling was qualitatively and quantitatively analysed. The dorsorostral part of F7 (supplementary eye field, F7-SEF) was found to be a target of strong afferents from the frontal eye field (FEF), from the dorsolateral prefrontal regions located dorsally (DLPFd) and ventrally (DLPFv) to the principal sulcus and from cingulate areas 24a, 24b and 24c. In contrast, the remaining part of F7 (F7-non SEF) is only a target of the strong afferents from DLPFd. Finally, the ventrorostral part of F2 (F2vr), but not the F2 sector located around the superior precentral dimple (F2d), receives a minor, but significant, input from DLPFd and a relatively strong input from the cingulate gyrus (areas 24a and 24b) and area 24d. Present data provide strong hodological support in favour of the idea that areas F7 and F2 are formed by two functionally distinct sectors.

  11. Common premotor regions for the perception and production of prosody and correlations with empathy and prosodic ability.

    Directory of Open Access Journals (Sweden)

    Lisa Aziz-Zadeh

    Full Text Available BACKGROUND: Prosody, the melody and intonation of speech, involves the rhythm, rate, pitch and voice quality to relay linguistic and emotional information from one individual to another. A significant component of human social communication depends upon interpreting and responding to another person's prosodic tone as well as one's own ability to produce prosodic speech. However there has been little work on whether the perception and production of prosody share common neural processes, and if so, how these might correlate with individual differences in social ability. METHODS: The aim of the present study was to determine the degree to which perception and production of prosody rely on shared neural systems. Using fMRI, neural activity during perception and production of a meaningless phrase in different prosodic intonations was measured. Regions of overlap for production and perception of prosody were found in premotor regions, in particular the left inferior frontal gyrus (IFG. Activity in these regions was further found to correlate with how high an individual scored on two different measures of affective empathy as well as a measure on prosodic production ability. CONCLUSIONS: These data indicate, for the first time, that areas that are important for prosody production may also be utilized for prosody perception, as well as other aspects of social communication and social understanding, such as aspects of empathy and prosodic ability.

  12. Involvement of the human dorsal premotor cortex in unimanual motor control: an interference approach using transcranial magnetic stimulation.

    Science.gov (United States)

    Cincotta, Massimo; Borgheresi, Alessandra; Balestrieri, Fabrizio; Giovannelli, Fabio; Rossi, Simone; Ragazzoni, Aldo; Zaccara, Gaetano; Ziemann, Ulf

    2004-09-02

    Unilateral movements are enabled through a distributed network of motor cortical areas but the relative contribution from the parts of this network is largely unknown. Failure of this network potentially results in mirror activation of the primary motor cortex (M1) ipsilateral to the intended movement. Here we tested the role of the right dorsal premotor cortex (dPMC) in 11 healthy subjects by disrupting its activity with 20 Hz repetitive transcranial magnetic stimulation (rTMS) whilst the subjects exerted a unilateral contraction of the left first dorsal interosseous (FDI). We found that disruption of right dPMC enhanced mirror activation of the ipsilateral left M1, as probed by motor evoked potential (MEP) amplitude to the right FDI. This was not the case with sham rTMS, when rTMS was directed to the right M1, or with rTMS of the right dPMC but without contraction of the left FDI. Findings suggest that activity in the dPMC contributes to the suppression of mirror movements during intended unilateral movements.

  13. Connecting to create: expertise in musical improvisation is associated with increased functional connectivity between premotor and prefrontal areas.

    Science.gov (United States)

    Pinho, Ana Luísa; de Manzano, Örjan; Fransson, Peter; Eriksson, Helene; Ullén, Fredrik

    2014-04-30

    Musicians have been used extensively to study neural correlates of long-term practice, but no studies have investigated the specific effects of training musical creativity. Here, we used human functional MRI to measure brain activity during improvisation in a sample of 39 professional pianists with varying backgrounds in classical and jazz piano playing. We found total hours of improvisation experience to be negatively associated with activity in frontoparietal executive cortical areas. In contrast, improvisation training was positively associated with functional connectivity of the bilateral dorsolateral prefrontal cortices, dorsal premotor cortices, and presupplementary areas. The effects were significant when controlling for hours of classical piano practice and age. These results indicate that even neural mechanisms involved in creative behaviors, which require a flexible online generation of novel and meaningful output, can be automated by training. Second, improvisational musical training can influence functional brain properties at a network level. We show that the greater functional connectivity seen in experienced improvisers may reflect a more efficient exchange of information within associative networks of importance for musical creativity.

  14. Circuit simulation: some humbling thoughts

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, Manfred; /Fermilab

    2006-01-01

    A short, very personal note on circuit simulation is presented. It does neither include theoretical background on circuit simulation, nor offers an overview of available software, but just gives some general remarks for a discussion on circuit simulator needs in context to the design and development of accelerator beam instrumentation circuits and systems.

  15. Analyzing fixed points of intracellular regulation networks with interrelated feedback topology

    Directory of Open Access Journals (Sweden)

    Radde Nicole

    2012-06-01

    Full Text Available Abstract Background Modeling the dynamics of intracellular regulation networks by systems of ordinary differential equations has become a standard method in systems biology, and it has been shown that the behavior of these networks is often tightly connected to the network topology. We have recently introduced the circuit-breaking algorithm, a method that uses the network topology to construct a one-dimensional circuit-characteristic of the system. It was shown that this characteristic can be used for an efficient calculation of the system’s fixed points. Results Here we extend previous work and show several connections between the circuit-characteristic and the stability of fixed points. In particular, we derive a sufficient condition on the characteristic for a fixed point to be unstable for certain graph structures and demonstrate that the characteristic does not contain the information to decide whether a fixed point is asymptotically stable. All statements are illustrated on biological network models. Conclusions Single feedback circuits and their role for complex dynamic behavior of biological networks have extensively been investigated, but a transfer of most of these concepts to more complex topologies is difficult. In this context, our algorithm is a powerful new approach for the analysis of regulation networks that goes beyond single isolated feedback circuits.

  16. Concept Model on Topological Learning

    Science.gov (United States)

    Ae, Tadashi; Kioi, Kazumasa

    2010-11-01

    We discuss a new model for concept based on topological learning, where the learning process on the neural network is represented by mathematical topology. The topological learning of neural networks is summarized by a quotient of input space and the hierarchical step induces a tree where each node corresponds to a quotient. In general, the concept acquisition is a difficult problem, but the emotion for a subject is represented by providing the questions to a person. Therefore, a kind of concept is captured by such data and the answer sheet can be mapped into a topology consisting of trees. In this paper, we will discuss a way of mapping the emotional concept to a topological learning model.

  17. Topological susceptibility from the overlap

    CERN Document Server

    Del Debbio, L; Debbio, Luigi Del; Pica, Claudio

    2004-01-01

    The chiral symmetry at finite lattice spacing of Ginsparg-Wilson fermionic actions constrains the renormalization of the lattice operators; in particular, the topological susceptibility does not require any renormalization, when using a fermionic estimator to define the topological charge. Therefore, the overlap formalism appears as an appealing candidate to study the continuum limit of the topological susceptibility while keeping the systematic errors under theoretical control. We present results for the SU(3) pure gauge theory using the index of the overlap Dirac operator to study the topology of the gauge configurations. The topological charge is obtained from the zero modes of the overlap and using a new algorithm for the spectral flow analysis. A detailed comparison with cooling techniques is presented. Particular care is taken in assessing the systematic errors. Relatively high statistics (500 to 1000 independent configurations) yield an extrapolated continuum limit with errors that are comparable with ...

  18. Combined Shape and Topology Optimization

    DEFF Research Database (Denmark)

    Christiansen, Asger Nyman

    Shape and topology optimization seeks to compute the optimal shape and topology of a structure such that one or more properties, for example stiffness, balance or volume, are improved. The goal of the thesis is to develop a method for shape and topology optimization which uses the Deformable...... Simplicial Complex (DSC) method. Consequently, we present a novel method which combines current shape and topology optimization methods. This method represents the surface of the structure explicitly and discretizes the structure into non-overlapping elements, i.e. a simplicial complex. An explicit surface...... representation usually limits the optimization to minor shape changes. However, the DSC method uses a single explicit representation and still allows for large shape and topology changes. It does so by constantly applying a set of mesh operations during deformations of the structure. Using an explicit instead...

  19. Topological susceptibility from the overlap

    DEFF Research Database (Denmark)

    Del Debbio, Luigi; Pica, Claudio

    2003-01-01

    The chiral symmetry at finite lattice spacing of Ginsparg-Wilson fermionic actions constrains the renormalization of the lattice operators; in particular, the topological susceptibility does not require any renormalization, when using a fermionic estimator to define the topological charge....... Therefore, the overlap formalism appears as an appealing candidate to study the continuum limit of the topological susceptibility while keeping the systematic errors under theoretical control. We present results for the SU(3) pure gauge theory using the index of the overlap Dirac operator to study...... the topology of the gauge configurations. The topological charge is obtained from the zero modes of the overlap and using a new algorithm for the spectral flow analysis. A detailed comparison with cooling techniques is presented. Particular care is taken in assessing the systematic errors. Relatively high...

  20. Topological defects in two-dimensional crystals

    OpenAIRE

    Chen, Yong; Qi, Wei-Kai

    2008-01-01

    By using topological current theory, we study the inner topological structure of the topological defects in two-dimensional (2D) crystal. We find that there are two elementary point defects topological current in two-dimensional crystal, one for dislocations and the other for disclinations. The topological quantization and evolution of topological defects in two-dimensional crystals are discussed. Finally, We compare our theory with Brownian-dynamics simulations in 2D Yukawa systems.

  1. Wireless Communication Electronics Introduction to RF Circuits and Design Techniques

    CERN Document Server

    Sobot, Robert

    2012-01-01

    This book is intended for senior undergraduate and graduate students as well as practicing engineers who are involved in design and analysis of radio frequency (RF) circuits.  Detailed tutorials are included on all major topics required to understand fundamental principles behind both the main sub-circuits required to design an RF transceiver and the whole communication system. Starting with review of fundamental principles in electromagnetic (EM) transmission and signal propagation, through detailed practical analysis of RF amplifier, mixer, modulator, demodulator, and oscillator circuit topologies, all the way to the system communication theory behind the RF transceiver operation, this book systematically covers all relevant aspects in a way that is suitable for a single semester university level course.   Offers readers a complete, self-sufficient tutorial style textbook; Includes all relevant topics required to study and design an RF receiver in a consistent, coherent way with appropriate depth for a on...

  2. Low latency asynchronous interface circuits

    Energy Technology Data Exchange (ETDEWEB)

    Sadowski, Greg

    2017-06-20

    In one form, a logic circuit includes an asynchronous logic circuit, a synchronous logic circuit, and an interface circuit coupled between the asynchronous logic circuit and the synchronous logic circuit. The asynchronous logic circuit has a plurality of asynchronous outputs for providing a corresponding plurality of asynchronous signals. The synchronous logic circuit has a plurality of synchronous inputs corresponding to the plurality of asynchronous outputs, a stretch input for receiving a stretch signal, and a clock output for providing a clock signal. The synchronous logic circuit provides the clock signal as a periodic signal but prolongs a predetermined state of the clock signal while the stretch signal is active. The asynchronous interface detects whether metastability could occur when latching any of the plurality of the asynchronous outputs of the asynchronous logic circuit using said clock signal, and activates the stretch signal while the metastability could occur.

  3. Mooses, Topology and Higgs

    CERN Document Server

    Gregoire, T; Gregoire, Thomas; Wacker, Jay G.

    2002-01-01

    New theories of electroweak symmetry breaking have recently been constructed that stabilize the weak scale and do not rely upon supersymmetry. In these theories the Higgs boson is a weakly coupled pseudo-Goldstone boson. In this note we study the class of theories that can be described by theory spaces and show that the fundamental group of theory space describes all the relevant classical physics in the low energy theory. The relationship between the low energy physics and the topological properties of theory space allow a systematic method for constructing theory spaces that give any desired low energy particle content and potential. This provides us with tools for analyzing and constructing new theories of electroweak symmetry breaking.

  4. The Orbifold Topological Vertex

    CERN Document Server

    Bryan, Jim; Young, Ben

    2010-01-01

    We define Donaldson-Thomas invariants of Calabi-Yau orbifolds and we develop a topological vertex formalism for computing them. The basic combinatorial object is the orbifold vertex, a generating function for the number of 3D partitions asymptotic to three given 2D partitions and colored by representations of a finite Abelian group G acting on C^3. In the case where G=Z_n acting on C^3 with transverse A_{n-1} quotient singularities, we give an explicit formula for the vertex in terms of Schur functions. We discuss applications of our formalism to the Donaldson-Thomas Crepant Resolution Conjecture and to the orbifold Donaldson-Thomas/Gromov-Witten correspondence. We also explicitly compute the Donaldson-Thomas partition function for some simple orbifold geometries: the local football and the local BZ_2 gerbe.

  5. Topological convolution algebras

    CERN Document Server

    Alpay, Daniel

    2012-01-01

    In this paper we introduce a new family of topological convolution algebras of the form $\\bigcup_{p\\in\\mathbb N} L_2(S,\\mu_p)$, where $S$ is a Borel semi-group in a locally compact group $G$, which carries an inequality of the type $\\|f*g\\|_p\\le A_{p,q}\\|f\\|_q\\|g\\|_p$ for $p > q+d$ where $d$ pre-assigned, and $A_{p,q}$ is a constant. We give a sufficient condition on the measures $\\mu_p$ for such an inequality to hold. We study the functional calculus and the spectrum of the elements of these algebras, and present two examples, one in the setting of non commutative stochastic distributions, and the other related to Dirichlet series.

  6. Design as Topology

    DEFF Research Database (Denmark)

    Ekman, Ulrik

    2015-01-01

    that increasingly develop mixed reality environments with context-aware out-of-the-box computing as well as the soci-ocultural and experiental horizon of a virtually and physically mobile citizenry. Design here must meet an ongoing and exceedingly complex interactivity among environmental, technical, social...... multiplicities of environmental, technical, and human interactants tend towards gathering and dispersing in a single mixed reality street transport scenario. The need for ‘intelligent’ ad hoc connection, routing, and disconnection of multitudes of humans, technical systems, and environmental entities makes....... It is demonstrated that design as topology offers significant resources with respect to traits of the u-city such as continuous material and energetic flows, its environmental landscaping of mixed realities, its ongoing virtual and physical infrastructural developments, the folding and unfolding of its architecture...

  7. On sequential countably compact topological semigroups

    CERN Document Server

    Gutik, Oleg V; Repovš, Dušan

    2008-01-01

    We study topological and algebraic properties of sequential countably compact topological semigroups similar to compact topological semigroups. We prove that a sequential countably compact topological semigroup does not contain the bicyclic semigroup. Also we show that the closure of a subgroup in a sequential countably compact topological semigroup is a topological group, that the inversion in a Clifford sequential countably compact topological semigroup is continuous and we prove the analogue of the Rees-Suschkewitsch Theorem for simple regular sequential countably compact topological semigroups.

  8. The Construction of Finer Compact Topologies

    OpenAIRE

    2005-01-01

    It is well known that each locally compact strongly sober topology is contained in a compact Hausdorff topology; just take the supremum of its topology with its dual topology. On the other hand, examples of compact topologies are known that do not have a finer compact Hausdorff topology. This led to the question (first explicitly formulated by D.E. Cameron) whether each compact topology is contained in a compact topology with respect to which all compact sets are closed. (For the obvious r...

  9. Dense topological spaces and dense continuity

    Science.gov (United States)

    Aldwoah, Khaled A.

    2013-09-01

    There are several attempts to generalize (or "widen") the concept of topological space. This paper uses equivalence relations to generalize the concept of topological space via the concept of equivalence relations. By the generalization, we can introduce from particular topology on a nonempty set X many new topologies, we call anyone of these new topologies a dense topology. In addition, we formulate some simple properties of dense topologies and study suitable generalizations of the concepts of limit points, closeness and continuity, as well as Jackson, Nörlund and Hahn dense topologies.

  10. Cultural Topology of Creativity

    Directory of Open Access Journals (Sweden)

    L. M. Andryukhina

    2012-01-01

    Full Text Available The man in the modern culture faces the challenge of either being creative or forced to leave the stage, which reflects the essential basics of life. The price of lost opportunities, caused by mental stereotypes and encapsulation, is gradually rising. The paper reveals the socio-cultural conditions and the necessary cultural topology of creativity development, as well as the man’s creative potential in the 21st century. The content of the creativity concept is specified along with the phenomenon of its fast expansion in the modern discourse. That results from the global spreading of numerous creative practices in various spheres of life, affecting the progress directions in economics, business, industrial technologies, labor, employment and social stratification. The author emphasizes the social features of creativity, the rising number of, so called, creative class, and outlines the two opposing strategies influencing the topology modification of the social and cultural environment. The first one, applied by the developed countries, facilitates the development of the creative human potential, whereas the other one, inherent in our country, holds that a creative person is able to make progress by himself. However, for solving the urgent problem of innovative development, the creative potential of modern Russia is not sufficient, and following the second strategy will result in unrealized social opportunities and ever lasting social and cultural situation demanding further investment. According to the author, to avoid such a perspective, it is necessary to overcome the three deeply rooted archetypes: the educational disciplinary centrism, organizational absolutism and cultural ostracism. 

  11. Cultural Topology of Creativity

    Directory of Open Access Journals (Sweden)

    L. M. Andryukhina

    2015-02-01

    Full Text Available The man in the modern culture faces the challenge of either being creative or forced to leave the stage, which reflects the essential basics of life. The price of lost opportunities, caused by mental stereotypes and encapsulation, is gradually rising. The paper reveals the socio-cultural conditions and the necessary cultural topology of creativity development, as well as the man’s creative potential in the 21st century. The content of the creativity concept is specified along with the phenomenon of its fast expansion in the modern discourse. That results from the global spreading of numerous creative practices in various spheres of life, affecting the progress directions in economics, business, industrial technologies, labor, employment and social stratification. The author emphasizes the social features of creativity, the rising number of, so called, creative class, and outlines the two opposing strategies influencing the topology modification of the social and cultural environment. The first one, applied by the developed countries, facilitates the development of the creative human potential, whereas the other one, inherent in our country, holds that a creative person is able to make progress by himself. However, for solving the urgent problem of innovative development, the creative potential of modern Russia is not sufficient, and following the second strategy will result in unrealized social opportunities and ever lasting social and cultural situation demanding further investment. According to the author, to avoid such a perspective, it is necessary to overcome the three deeply rooted archetypes: the educational disciplinary centrism, organizational absolutism and cultural ostracism. 

  12. A semiconductor laser excitation circuit

    Energy Technology Data Exchange (ETDEWEB)

    Kaadzunari, O.; Masaty, K.

    1984-03-27

    A semiconductor laser excitation circuit is patented that is designed for operation in a pulsed mode with a high pulse repetition frequency. This circuit includes, in addition to a semiconductor laser, a high speed photodetector, a reference voltage source, a comparator, and a pulse oscillator and modulator. If the circuit is built using standard silicon integrated circuits, its speed amounts to several hundred megahertz, if it is constructed using gallium arsenide integrated circuits, its speed is several gigahertz.

  13. Combining Topological Hardware and Topological Software: Color-Code Quantum Computing with Topological Superconductor Networks

    Directory of Open Access Journals (Sweden)

    Daniel Litinski

    2017-09-01

    Full Text Available We present a scalable architecture for fault-tolerant topological quantum computation using networks of voltage-controlled Majorana Cooper pair boxes and topological color codes for error correction. Color codes have a set of transversal gates which coincides with the set of topologically protected gates in Majorana-based systems, namely, the Clifford gates. In this way, we establish color codes as providing a natural setting in which advantages offered by topological hardware can be combined with those arising from topological error-correcting software for full-fledged fault-tolerant quantum computing. We provide a complete description of our architecture, including the underlying physical ingredients. We start by showing that in topological superconductor networks, hexagonal cells can be employed to serve as physical qubits for universal quantum computation, and we present protocols for realizing topologically protected Clifford gates. These hexagonal-cell qubits allow for a direct implementation of open-boundary color codes with ancilla-free syndrome read-out and logical T gates via magic-state distillation. For concreteness, we describe how the necessary operations can be implemented using networks of Majorana Cooper pair boxes, and we give a feasibility estimate for error correction in this architecture. Our approach is motivated by nanowire-based networks of topological superconductors, but it could also be realized in alternative settings such as quantum-Hall–superconductor hybrids.

  14. Imperfect two-dimensional topological insulator field-effect transistors

    Science.gov (United States)

    Vandenberghe, William G.; Fischetti, Massimo V.

    2017-01-01

    To overcome the challenge of using two-dimensional materials for nanoelectronic devices, we propose two-dimensional topological insulator field-effect transistors that switch based on the modulation of scattering. We model transistors made of two-dimensional topological insulator ribbons accounting for scattering with phonons and imperfections. In the on-state, the Fermi level lies in the bulk bandgap and the electrons travel ballistically through the topologically protected edge states even in the presence of imperfections. In the off-state the Fermi level moves into the bandgap and electrons suffer from severe back-scattering. An off-current more than two-orders below the on-current is demonstrated and a high on-current is maintained even in the presence of imperfections. At low drain-source bias, the output characteristics are like those of conventional field-effect transistors, at large drain-source bias negative differential resistance is revealed. Complementary n- and p-type devices can be made enabling high-performance and low-power electronic circuits using imperfect two-dimensional topological insulators. PMID:28106059

  15. Some New Sets and Topologies in Ideal Topological Spaces

    Directory of Open Access Journals (Sweden)

    R. Manoharan

    2013-01-01

    Full Text Available An ideal topological space is a triplet (X, τ, ℑ, where X is a nonempty set, τ is a topology on X, and ℑ is an ideal of subsets of X. In this paper, we introduce L∗-perfect, R∗-perfect, and C∗-perfect sets in ideal spaces and study their properties. We obtained a characterization for compatible ideals via R∗-perfect sets. Also, we obtain a generalized topology via ideals which is finer than τ using R∗-perfect sets on a finite set.

  16. The Mind Grows Circuits

    CERN Document Server

    Panigrahy, Rina

    2012-01-01

    There is a vast supply of prior art that study models for mental processes. Some studies in psychology and philosophy approach it from an inner perspective in terms of experiences and percepts. Others such as neurobiology or connectionist-machines approach it externally by viewing the mind as complex circuit of neurons where each neuron is a primitive binary circuit. In this paper, we also model the mind as a place where a circuit grows, starting as a collection of primitive components at birth and then builds up incrementally in a bottom up fashion. A new node is formed by a simple composition of prior nodes when we undergo a repeated experience that can be described by that composition. Unlike neural networks, however, these circuits take "concepts" or "percepts" as inputs and outputs. Thus the growing circuits can be likened to a growing collection of lambda expressions that are built on top of one another in an attempt to compress the sensory input as a heuristic to bound its Kolmogorov Complexity.

  17. Time-domain analysis methodology for large-scale RLC circuits and its applications

    Institute of Scientific and Technical Information of China (English)

    LUO Zuying; CAI Yici; Sheldon X.-D Tan; HONG Xianlong; WANG Xiaoyi; PAN Zhu; FU Jingjing

    2006-01-01

    With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts: 1) An approach is proposed to delete all intermediate nodes of RL branches. 2) An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3) The Y to ( transformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground (P/G) networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks.

  18. Synthesizing topological structures containing RNA

    Science.gov (United States)

    Liu, Di; Shao, Yaming; Chen, Gang; Tse-Dinh, Yuk-Ching; Piccirilli, Joseph A.; Weizmann, Yossi

    2017-03-01

    Though knotting and entanglement have been observed in DNA and proteins, their existence in RNA remains an enigma. Synthetic RNA topological structures are significant for understanding the physical and biological properties pertaining to RNA topology, and these properties in turn could facilitate identifying naturally occurring topologically nontrivial RNA molecules. Here we show that topological structures containing single-stranded RNA (ssRNA) free of strong base pairing interactions can be created either by configuring RNA-DNA hybrid four-way junctions or by template-directed synthesis with a single-stranded DNA (ssDNA) topological structure. By using a constructed ssRNA knot as a highly sensitive topological probe, we find that Escherichia coli DNA topoisomerase I has low RNA topoisomerase activity and that the R173A point mutation abolishes the unknotting activity for ssRNA, but not for ssDNA. Furthermore, we discover the topological inhibition of reverse transcription (RT) and obtain different RT-PCR patterns for an ssRNA knot and circle of the same sequence.

  19. Chaotic memristive circuit: equivalent circuit realization and dynamical analysis

    Institute of Scientific and Technical Information of China (English)

    Bao Bo-Cheng; Xu Jian-Ping; Zhou Guo-Hua; Ma Zheng-Hua; Zou Ling

    2011-01-01

    In this paper,a practical equivalent circuit of an active flux-controlled memristor characterized by smooth piecewise-quadratic nonlinearity is designed and an experimental chaotic memristive circuit is implemented.The chaotic memristive circuit has an equilibrium set and its stability is dependent on the initial state of the memristor.The initial state-dependent and the circuit parameter-dependent dynamics of the chaotic memristive circuit are investigated via phase portraits,bifurcation diagrams and Lyapunov exponents.Both experimental and simulation results validate the proposed equivalent circuit realization of the active flux-controlled memristor.

  20. Topology Optimization using a Topology Description Function Approach

    NARCIS (Netherlands)

    de Ruiter, M.J.

    2005-01-01

    During the last two decades, computational structural optimization methods have emerged, as computational power increased tremendously. Designers now have topological optimization routines at their disposal. These routines are able to generate the entire geometry of structures, provided only with in