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  1. Clinical predictors of decline in nutritional parameters over time in ESRD

    NARCIS (Netherlands)

    C.H. den Hoedt (Claire); M.L. Bots (Michiel); M.P.C. Grooteman (Muriel); N.C. van der Weerd (Neelke); E.L. Penne (Lars); A.H.A. Mazairac (Albert); R. Lévesque (Renée); P.J. Blankestijn (Peter); M.J. Nubé (Menso); P.M. ter Wee (Piet); M.A. van den Dorpel (Marinus)

    2014-01-01

    textabstractBackground and objectives: Inflammation and malnutrition are important features in patients with ESRD; however, data on changes in these parameters over time are scarce. This study aimed to gain insight into changes over time in serum albumin, body mass index, high-sensitivity C-reactive

  2. Clinical predictors of decline in nutritional parameters over time in ESRD

    NARCIS (Netherlands)

    Hoedt, C.H. den; Bots, M.L.; Grooteman, M.P.C.; Weerd, N.C. van der; Penne, E.L.; Mazairac, A.H.; Levesque, R.; Blankestijn, P.J.; Nube, M.J.; Wee, P.M. ter; Dorpel, M.A. van den; Dorval, M.; Lévesque, R.; Koopman, M.G.; Konings, C.J.; Haanstra, W.P.; Kooistra, M.; Jaarsveld, B. van; Noordzij, T.; Peltenburg, H.G.; Buren, M. van; Offerman, J.J.; Hoogeveen, E.K.; Heer, F. de; Ven, P.J. van der; Hovinga, T.K.; Bax, W.A.; Groeneveld, J.O.; Lavrijssen, A.T.; Schrander-van der Meer, A.M.; Reichert, L.J.; Huussen, J.; Rensma, P.L.; Schrama, Y.; Hamersvelt, H.W. van; Boer, W.H.; Kuijk, W.H.; Vervloet, M.; Wauters, I.M.; Sekse, I.

    2014-01-01

    BACKGROUND AND OBJECTIVES: Inflammation and malnutrition are important features in patients with ESRD; however, data on changes in these parameters over time are scarce. This study aimed to gain insight into changes over time in serum albumin, body mass index, high-sensitivity C-reactive protein, an

  3. Time trends in the association of ESRD incidence with area-level poverty in the US population.

    Science.gov (United States)

    Garrity, Bridget H; Kramer, Holly; Vellanki, Kavitha; Leehey, David; Brown, Julia; Shoham, David A

    2016-01-01

    The objective of this study was to examine the temporal trends of the association between area-level poverty status and end-stage renal disease (ESRD) incidence. We hypothesized that the association between area-level poverty status and ESRD incidence has increased significantly over time. Patient data from the United States Renal Data System were linked with data from the 2000 and 2010 US census. Area-level poverty was defined as living in a zip code-defined area with ≥20% of households living below the federal poverty line. Negative binomial regression models were created to examine the association between area-level poverty status and ESRD incidence by time period in the US adult population while simultaneously adjusting for the distribution of age, sex, and race/ethnicity within a zip code. Time was categorized as January 1, 1995 through December 31, 2004 (Period 1) and January 1, 2005 through December 31, 2010 (Period 2). The percentage of adults initiating dialysis with area-level poverty increased from 27.4% during Period 1 to 34.0% in Period 2. After accounting for the distribution of age, sex, and race/ethnicity within a zip code, area-level poverty status was associated with a 1.24 (95% confidence interval [CI] 1.22, 1.25)-fold higher ESRD incidence. However, this association differed by time period with 1.04-fold (95% CI 1.02, 1.05) higher ESRD incidence associated with poverty status for Period 2 compared with the association between ESRD and poverty status in Period 1. Area-level poverty and its association with ESRD incidence is not static over time.

  4. ESRD Payment System

    Data.gov (United States)

    U.S. Department of Health & Human Services — Medicare payment to ESRD facilities for outpatient maintenance dialysis services furnished to Medicare beneficiaries with End-Stage Renal Disease (ESRD) is based on...

  5. Serious Illness Conversations in ESRD.

    Science.gov (United States)

    Mandel, Ernest I; Bernacki, Rachelle E; Block, Susan D

    2017-05-08

    Dialysis-dependent ESRD is a serious illness with high disease burden, morbidity, and mortality. Mortality in the first year on dialysis for individuals over age 75 years old approaches 40%, and even those with better prognoses face multiple hospitalizations and declining functional status. In the last month of life, patients on dialysis over age 65 years old experience higher rates of hospitalization, intensive care unit admission, procedures, and death in hospital than patients with cancer or heart failure, while using hospice services less. This high intensity of care is often inconsistent with the wishes of patients on dialysis but persists due to failure to explore or discuss patient goals, values, and preferences in the context of their serious illness. Fewer than 10% of patients on dialysis report having had a conversation about goals, values, and preferences with their nephrologist, although nearly 90% report wanting this conversation. Many nephrologists shy away from these conversations, because they do not wish to upset their patients, feel that there is too much uncertainty in their ability to predict prognosis, are insecure in their skills at broaching the topic, or have difficulty incorporating the conversations into their clinical workflow. In multiple studies, timely discussions about serious illness care goals, however, have been associated with enhanced goal-consistent care, improved quality of life, and positive family outcomes without an increase in patient distress or anxiety. In this special feature article, we will (1) identify the barriers to serious illness conversations in the dialysis population, (2) review best practices in and specific approaches to conducting serious illness conversations, and (3) offer solutions to overcome barriers as well as practical advice, including specific language and tools, to implement serious illness conversations in the dialysis population. Copyright © 2017 by the American Society of Nephrology.

  6. Living Kidney Donors and ESRD

    OpenAIRE

    Ross, Lainie Friedman

    2015-01-01

    There are over 325 living kidney donors who have developed end-stage renal disease (ESRD) and have been listed on the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) deceased donor kidney wait list. The OPTN/UNOS database records where these kidney donors are listed and, if they donated after April 1994, where that donation occurred. These two locations are often not the same. In this commentary, I examine whether a national living donor registry s...

  7. Sleep Disorders in ESRD Patients Undergoing Hemodialysis

    OpenAIRE

    Mohammad Reza Abassi; Amin Safavi; Masoumeh Haghverdi; Babak Saedi

    2016-01-01

    Kidney failure affects different aspects of normal life. Among different manifestations, sleep problem can be considered as a common complaint of ESRD (End Stage Renal Disease) patients. In this study, we aimed to investigate the interrelationship between sleep disorders in ESRD patients and their characteristics. Through a cross-sectional study (2010-2011), 88 ESRD patients undergoing maintenance hemodialysis thrice weekly were recruited to enter the study. We used a self-administered questi...

  8. [ESRD in children and adolescents].

    Science.gov (United States)

    Harambat, J; Hogan, J; Macher, M-Al; Couchoud, C

    2013-09-01

    This chapter provides indicators to describe the specificity of End Stage Renal Disease in children in France and to study these patients'outcome and the choices of treatment modalities. In 2011, the incidence and the prevalence of ESRD among patients under 20 years old remained stable at 8 and 53 pmp respectively. The first causes of ESDR remain uropathies and hypodysplasia followed by glomerulonephritis and genetic diseases. Considering the initial treatment, we found a high rate of hemodialysis and a low rate of peritoneal dialysis that is mainly used in younger children. In 2011, 31 preemptive transplantations were performed accounting for 27.7% of new patients. Finally, survival analysis confirm that younger children (under 4 years old) have the highest risk of death (88% survival rate at 2 years vs. 98% in patients over 4 years old) and that the treatment of choice remains the renal transplantation since it increases the expected remaining lifetime of 20 to 40 years depending on the considered age. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  9. ESRD QIP - Vascular Access - Payment Year 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — Payment Year 2015 ESRD QIP data by facility: % hemodialysis patients using an arteriovenous fistula, % hemodialysis patients using an intravenous catheter

  10. ESRD QIP - Vascular Access - Payment Year 2015

    Data.gov (United States)

    U.S. Department of Health & Human Services — Payment Year 2015 ESRD QIP data by facility: % hemodialysis patients using an arteriovenous fistula, % hemodialysis patients using an intravenous catheter

  11. Advance care planning in CKD/ESRD: an evolving process.

    Science.gov (United States)

    Holley, Jean L

    2012-06-01

    Advance care planning was historically considered to be simply the completion of a proxy (health care surrogate designation) or instruction (living will) directive that resulted from a conversation between a patient and his or her physician. We now know that advance care planning is a much more comprehensive and dynamic patient-centered process used by patients and families to strengthen relationships, achieve control over medical care, prepare for death, and clarify goals of care. Some advance directives, notably designated health care proxy documents, remain appropriate expressions of advance care planning. Moreover, although physician orders, such as do-not-resuscitate orders and Physician Orders for Life-Sustaining Treatment, may not be strictly defined as advance directives, their completion, when appropriate, is an integral component of advance care planning. The changing health circumstances and illness trajectory characteristic of ESRD mandate that advance care planning discussions adapt to a patient's situation and therefore must be readdressed at appropriate times and intervals. The options of withholding and withdrawing dialysis add ESRD-specific issues to advance care planning in this population and are events each nephrologist will at some time confront. Advance care planning is important throughout the spectrum of ESRD and is a part of nephrology practice that can be rewarding to nephrologists and beneficial to patients and their families.

  12. ESRD QIP - Dialysis Adequacy - Payment Year 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — ESRD QIP data by facility: % of hemodialysis patient-months with spKt/V >= 1.2; % of peritoneal patient-months with Kt/V >= 1.7 Kt/V (dialytic + residual)...

  13. ESRD QIP - Dialysis Adequacy - Payment Year 2015

    Data.gov (United States)

    U.S. Department of Health & Human Services — ESRD QIP data by facility: % of hemodialysis patient-months with spKt/V >= 1.2; % of peritoneal patient-months with Kt/V >= 1.7 Kt/V (dialytic + residual)...

  14. [The prevalence of ESRD in 2011].

    Science.gov (United States)

    Jacquelinet, C; Lange, C; Briançon, S

    2013-09-01

    This chapter describes temporal and geographical variations of ESRD prevalence in France. This indicator assesses health needs of ESRD patients on dialysis or living with functional transplant. It does not include patients on conservative treatment. On December 31, 2011, 70 300 patients were receiving a renal replacement therapy in one of the 25 regions contributing to the registry, 39 200 (56%) on dialysis and 31 100 (44%) living with a functional renal transplant. The overall crude prevalence was 1091pmh. It was 1.6 higher in males. Prevalence was subject to regional variations with 5 regions (3 overseas) above the national rate. Renal transplant share varied from 33% in Nord-Pas-de-Calais to 53% in Pays de Loire, and from 16 to 25% in overseas regions. The overall sex and age standardised prevalence was 40, 567 and 483 pmh respectively for peritoneal dialysis, haemodialysis and transplantation, with marked regional variations. The study of temporal variations for 18 regions contributing to the registry since 2007 demonstrated a +4% increase in standardised prevalence of ESRD patients with a functional transplant vs +2% increase for dialysis, resulting in a decreasing gap between dialysis and transplantation prevalence, due to an increase number of renal transplant and a longer survival of transplanted patients. Such an evolution should prompt the nephrological community and health authorities to anticipate changes in the ESRD healthcare organisation and to adapt them to the regional context. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  15. End-Stage Renal Disease (ESRD) Quality Initiative

    Data.gov (United States)

    U.S. Department of Health & Human Services — The End Stage Renal Disease (ESRD) Quality Initiative promotes ongoing CMS strategies to improve the quality of care provided to ESRD patients. This initiative...

  16. ESRD QIP - Standardized Readmission Ratio - Payment Year 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — ESRD QIP – Standardized Readmission Ratio – Payment Year 2017 Lists standardized readmission data used by ESRD QIP to assess dialysis facility performance.

  17. Sleep Disorders in ESRD Patients Undergoing Hemodialysis

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Abassi

    2016-04-01

    Full Text Available Kidney failure affects different aspects of normal life. Among different manifestations, sleep problem can be considered as a common complaint of ESRD (End Stage Renal Disease patients. In this study, we aimed to investigate the interrelationship between sleep disorders in ESRD patients and their characteristics. Through a cross-sectional study (2010-2011, 88 ESRD patients undergoing maintenance hemodialysis thrice weekly were recruited to enter the study. We used a self-administered questionnaire into which the data were reflected. The patients selected their specific sleep disorders using a nine-item scale while the Epworth Sleepiness Scale (ESS determined both the presence and severity of sleep disorders. The data was finally analyzed with their baseline characteristics, dialysis characteristics, medication/stimulants use, and clinical and biochemical parameters. Over 95% of the patients had, at least, one specific sleep disorder while the ESS revealed 36.36% of patients as normal, 59.09% as having mild sleep disorders, and 4.54% as having moderate to severe sleep disorders. Sleep disorders were significantly correlated with older ages (P=0.035, dialysis dose (P=0.001, blood creatinine levels (P=0.037, upper airways obstruction (P=0.035, hepatomegaly (P=0.006, hepatic failure (P=0.001, higher blood TSH levels (P=0.039, history of hypothyroidism (P=0.005, and the use of levodopa (P=0.004, anti-hypertensive medications (P=0.006, benzodiazepines (P=0.006, Eprex (Erythropoietin (P=0.001, Venofer (Iron Sucrose Injection (P=0.013, and phosphate-binders agents (P=0.018. Sleep disorders are common findings among ESRD patients and seem to be a more complicated issue than a simple accumulation of the wastes products in the body. Whatever the causes of sleep disorders are, disorder-specific treatments should be considered.

  18. Projection of the supply of and demand for board-certified nephrologists for ESRD in Taiwan.

    Science.gov (United States)

    Chang, Huan-Cheng; Liou, Yi-Min; Yen, Amy Ming-Fang; Chen, Tony Hsiu-Hsi

    2008-04-01

    Taiwan is the country where end-stage renal disease (ESRD) is most prevalent. The purpose of this study was to investigate whether the rising demand for dialysis or transplantation as a result of ESRD can be balanced by the supply of board-certified (B-C) nephrologists. Two Markov processes were applied for the projection of the supply of B-C nephrologists in ESRD and for the projection of the demand from ESRD in 2020, assuming linear, exponential growth and no increase. The supply of B-C nephrologists was projected at 1346 in 2020. To make allowance for the share of total time of professional activities in full-time equivalent (FTE) for B-C nephrologists, the demand was 1556, 962 and 2652 with assumptions of steady, linear and exponential growth, respectively. By the year 2020, 210 and 1306 additional FTE nephrologists will be required to meet, respectively, a linear and an exponential increase in demand from ESRD. The projection of the supply of and the demand for B-C nephrologists was made in this study using two Markov processes. The methods and results can be adopted as a reference for health manpower planning on B-C nephrologists.

  19. Neighborhood poverty and racial differences in ESRD incidence.

    Science.gov (United States)

    Volkova, Nataliya; McClellan, William; Klein, Mitchel; Flanders, Dana; Kleinbaum, David; Soucie, J Michael; Presley, Rodney

    2008-02-01

    Poverty is associated with increased risk of ESRD, but its contribution to observed racial differences in disease incidence is not well-defined. To explore the contribution of neighborhood poverty to racial disparity in ESRD incidence, we analyzed a combination of US Census and ESRD Network 6 data comprising 34,767 patients that initiated dialysis in Georgia, North Carolina, or South Carolina between January 1998 and December 2002. Census tracts were used as the geographic units of analysis, and the proportion of the census tract population living below the poverty level was our measure of neighborhood poverty. Incident ESRD rates were modeled using two-level Poisson regression, where race, age and gender were individual covariates (level 1), and census tract poverty was a neighborhood covariate (level 2). Neighborhood poverty was strongly associated with higher ESRD incidence for both blacks and whites. Increasing poverty was associated with a greater disparity in ESRD rates between blacks and whites, with the former at greater risk. This raises the possibility that blacks may suffer more from lower socioeconomic conditions than whites. The disparity persisted across all poverty levels. The reasons for increasingly higher ESRD incidence among US blacks as neighborhood poverty increases remain to be explained.

  20. APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease.

    Science.gov (United States)

    Fine, Derek M; Wasser, Walter G; Estrella, Michelle M; Atta, Mohamed G; Kuperman, Michael; Shemer, Revital; Rajasekaran, Arun; Tzur, Shay; Racusen, Lorraine C; Skorecki, Karl

    2012-02-01

    With earlier institution of antiretroviral therapy, kidney diseases other than HIV-associated nephropathy (HIVAN) predominate in HIV-infected persons. Outcomes for these diseases are typically worse among those infected with HIV, but the reasons for this are not clear. Here, we examined the role of APOL1 risk variants in predicting renal histopathology and progression to ESRD in 98 HIV-infected African Americans with non-HIVAN kidney disease on biopsy. We used survival analysis to determine time to ESRD associated with APOL1 genotype. Among the 29 patients with two APOL1 risk alleles, the majority (76%) had FSGS and 10% had hypertensive nephrosclerosis. In contrast, among the 54 patients with one APOL1 risk allele, 47% had immune-complex GN as the predominant lesion and only 23% had FSGS. Among the 25 patients with no APOL1 risk allele, 40% had immune-complex GN and 12% had FSGS. In 310 person-years of observation, 29 patients progressed to ESRD. In adjusted analyses, individuals with two APOL1 risk alleles had a nearly three-fold higher risk for ESRD compared with those with one or zero risk alleles (P=0.03). In summary, these data demonstrate an association between APOL1 variants and renal outcomes in non-HIVAN kidney disease, suggesting a possible use for APOL1 genotyping to help guide the care of HIV-infected patients.

  1. ESRD QIP - Complete QIP Data - Payment Year 2015

    Data.gov (United States)

    U.S. Department of Health & Human Services — The data set includes the number of eligible patients by clinical measure; % patients with Hemoglobin > 12; ESRD QIP data by facility: % of hemodialysis...

  2. ESRD QIP - Complete QIP Data - Payment Year 2017

    Data.gov (United States)

    U.S. Department of Health & Human Services — The data set includes the number of eligible patients by clinical measure; % patients with Hemoglobin > 12; ESRD QIP data by facility: % of hemodialysis...

  3. Impact of Hyperuricemia on Cardiovascular System in ESRD Patients

    OpenAIRE

    Mostafa Kamel, Magdy El-Sharkawy, Essam Afifi, Medhat Ali, Ahmed Ramadan

    2013-01-01

    Background: Hyperuricemia was found to be associated with hypertension, coronary heart disease, metabolic syndrome and chronic kidney disease. However there are no specific data about the relationship of uric acid to cardiovascular disease and mortality in ESRD patients on chronic hemodialysis.So, we aimed to study the impact of hyperuricemia on cardiovascular system in chronic kidney disease and in ESRD patients on regular hemodialysisPatients and methods: This study included 100 patients in...

  4. Sodium Intake, ACE Inhibition, and Progression to ESRD

    NARCIS (Netherlands)

    Vegter, Stefan; Perna, Annalisa; Postma, Maarten J.; Navis, Gerjan; Remuzzi, Giuseppe; Ruggenenti, Piero

    2012-01-01

    High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary sodium also associates with progression to ESRD is unknown. We conducted a post hoc analysis of the first and second Ramipril Ef

  5. Sodium Intake, ACE Inhibition, and Progression to ESRD

    NARCIS (Netherlands)

    Vegter, Stefan; Perna, Annalisa; Postma, Maarten J.; Navis, Gerjan; Remuzzi, Giuseppe; Ruggenenti, Piero

    2012-01-01

    High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary sodium also associates with progression to ESRD is unknown. We conducted a post hoc analysis of the first and second Ramipril Ef

  6. The MDRD formula does not reflect GFR in ESRD patients

    NARCIS (Netherlands)

    D.C. Grootendorst; W.M. Michels; J.D. Richardson; K.J. Jager; E.W. Boeschoten; F.W. Dekker; R.T. Krediet

    2011-01-01

    The Modification of Diet in Renal Disease (MDRD) equation is widely used for the estimation of glomerular filtration rate (GFR) from plasma creatinine. It has been well validated in patients with various degrees of impaired kidney function, but not in patients with end-stage renal disease (ESRD). Pl

  7. Impact of Hyperuricemia on Cardiovascular System in ESRD Patients

    Directory of Open Access Journals (Sweden)

    Mostafa Kamel, Magdy El-Sharkawy, Essam Afifi, Medhat Ali, Ahmed Ramadan

    2013-07-01

    Full Text Available Background: Hyperuricemia was found to be associated with hypertension, coronary heart disease, metabolic syndrome and chronic kidney disease. However there are no specific data about the relationship of uric acid to cardiovascular disease and mortality in ESRD patients on chronic hemodialysis.So, we aimed to study the impact of hyperuricemia on cardiovascular system in chronic kidney disease and in ESRD patients on regular hemodialysisPatients and methods: This study included 100 patients in Ashmoun hospital, nephrology department. Patients were chosen and divided into two groups: Group A, 50cases with chronic kidney disease and Group B, 50cases of ESRD on regular hemodialysis. All cases were subjected to full clinical examination, measurement of eGFR, laboratory tests for blood urea, serum creatinine and serum uric acid and ECG.Results: Serum uric acid was significantly higher in dialysis group than CKD group (p0.05.Conclusion: In cases of CKD uric acid is involved in the pathogenesis of renal failure and hypertension. In patients with ESRD, hyperuricemia is not a risk factor for the development of cardiac disease; but it shows reversed epidemiology and becomes a marker of good nutritious status. Further studies should be done on wider scales to evaluate the impact of hyperuricemia on cardiovascular system in hemodialysis patients.

  8. 42 CFR 405.2110 - Designation of ESRD networks.

    Science.gov (United States)

    2010-10-01

    ... MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Conditions for Coverage of Suppliers of.... (a) Effect on patient choice of facility. The designation of networks does not require an ESRD... does the designation of networks limit patient choice of physicians or facilities, or preclude...

  9. Individuals with a family history of ESRD are a high-risk population for CKD: implications for targeted surveillance and intervention activities.

    Science.gov (United States)

    McClellan, William M; Satko, Scott G; Gladstone, Elisa; Krisher, Jenna O; Narva, Andrew S; Freedman, Barry I

    2009-03-01

    Activities intended to improve the detection, treatment, and control of chronic kidney disease (CKD) should be incorporated into existing health care systems and targeted to high-risk populations to avoid redundancy and waste of resources. One high-risk population consists of first- or second-degree family members of patients with end-stage renal disease (ESRD), who are 2 to 3 times as likely to have incident ESRD, have high rates of impaired kidney function and undetected and uncontrolled high blood pressure, and are more likely to be obese. These individuals usually are unaware of their underlying CKD and may discount their own risk of ESRD. The ESRD Network 6 Family History Project shows that the ESRD Networks, which constitute a national CKD surveillance system for patients with stage 5 CKD, may be an existing resource that can be used to identify relatives of incident patients with ESRD and provide these families with information about CKD. Nationally available resources have been developed by the National Kidney Disease Education Program for use with these at-risk families. Individuals interested in population-based CKD control activities should be aware of and use these resources.

  10. HLA Class I and Class II Associations with ESRD in Saudi Arabian Population

    OpenAIRE

    Nuha Mahmoud Hamdi; Fadel Hassan Al-Hababi; Amr Ekhlas Eid

    2014-01-01

    BACKGROUND: Chronic renal failure (CRF) leads in the majority of instances to end stage renal disease (ESRD) requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population. METHODOLOGY: A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated ...

  11. 42 CFR 417.423 - Special rules: ESRD and hospice patients.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules: ESRD and hospice patients. 417.423... Special rules: ESRD and hospice patients. (a) ESRD patients. (1) A Medicare beneficiary who has been... not disenroll the beneficiary except as provided in § 417.460. (b) Hospice patients. A...

  12. Onset Time of 2% Lidocaine and 0.5% Bupivacaine Mixture versus 0.5% Bupivacaine Alone using Ultrasound and Double Nerve Stimulation for Infraclavicular Brachial Plexus Anesthesia in ESRD Patients Undergoing Arteriovenous Fistula Creation.

    Science.gov (United States)

    Pongraweewan, Orawan; Inchua, Nipa; Kitsiripant, Chanatthee; Kongmuang, Benchawan; Tiwirach, Wannapa

    2016-05-01

    To reduce the onset of 0.5% bupivacaine by adding 2% lidocaine with 0.5% bupivacaine for ultrasound-guided and double stimulation technique at musculocutaneous and radial nerve for infraclavicular brachial plexus block. Prospective randomized double-blinded, controlled trial study. 90 patients undergoing creation of arteriovenous fistula under ultrasound-guided infraclavicular brachial plexus block were randomized into 2 groups. Gr B (46 patients) received 0.5% bupivacaine 30 mL and Gr BL (44 patients) received mixture of 0.5% bupivacaine 20 mL and 2% lidocaine 10 mL. The onset of sensory block were assessed by response to pinprick (grading: 0 = no sensation, 1 = hypoesthesia, and 2 = normal sensation). Rescue analgesia during the operation, duration of sensory and motor blockade were recorded. Surgeon and patient satisfactions are also evaluated using 6-point scale (0 = dissatisfied to 5 = very satisfied). There were no significant difference in the onset time of either group. Duration of sensory and motor block was not different. Surgeons' and patients' satisfaction were also not significantly different between the groups. Mixing 2% lidocaine with 0.5% bupivacaine to the final concentration of 0.67%for lidocaine and 0.33% for bupivacaine does not reduce the onset of ultrasound-guided infraclavicular brachial plexus block.

  13. Marijuana and Cannabinoids in ESRD and Earlier Stages of CKD.

    Science.gov (United States)

    Rein, Joshua L; Wyatt, Christina M

    2017-08-12

    Marijuana is the most commonly used recreational drug in the United States, and legal recreational and medicinal use has gained public acceptance during the last decade. Twenty-nine US states have established medical marijuana programs, 8 of which have also legalized recreational marijuana, and Canada is expected to legalize recreational marijuana in 2018. Advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) are chronic conditions with significant associated morbidity and mortality. Patients experience substantial symptom burden that is frequently undertreated due to adverse medication side effects. This article reviews the available evidence for the use of medical marijuana to manage chronic pain, nausea/vomiting, anorexia/cachexia, and pruritus, all of which are frequently reported by patients with advanced CKD or ESRD. Potential adverse health effects of medical and recreational marijuana use are also discussed. Regardless of personal, social, and political beliefs, marijuana use is becoming mainstream, and nephrologists should be aware of the potential impact on our patient population. Further research is warranted to investigate the renal endocannabinoid system, the impact of marijuana use on kidney disease outcomes, and the risks and benefits of medical marijuana use on symptoms of advanced CKD and ESRD. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  14. Glycemic management in ESRD and earlier stages of CKD.

    Science.gov (United States)

    Williams, Mark E; Garg, Rajesh

    2014-02-01

    The management of hyperglycemia in patients with kidney failure is complex, and the goals and methods regarding glycemic control in chronic kidney disease (CKD) are not clearly defined. Although aggressive glycemic control seems to be advantageous in early diabetic nephropathy, outcome data supporting tight glycemic control in patients with advanced CKD (including end-stage renal disease [ESRD]) are lacking. Challenges in the management of such patients include therapeutic inertia, monitoring difficulties, and the complexity of available treatments. In this article, we review the alterations in glucose homeostasis that occur in kidney failure, current views on the value of glycemic control and issues with its determination, and more recent approaches to monitor or measure glycemic control. Hypoglycemia and treatment options for patients with diabetes and ESRD or earlier stages of CKD also are addressed, discussing the insulin and noninsulin agents that currently are available, along with their indications and contraindications. The article provides information to help clinicians in decision making in order to provide individualized glycemic goals and appropriate therapy for patients with ESRD or earlier stages of CKD.

  15. Variation in Cancer Incidence among Patients with ESRD during Kidney Function and Nonfunction Intervals.

    Science.gov (United States)

    Yanik, Elizabeth L; Clarke, Christina A; Snyder, Jon J; Pfeiffer, Ruth M; Engels, Eric A

    2016-05-01

    Among patients with ESRD, cancer risk is affected by kidney dysfunction and by immunosuppression after transplant. Assessing patterns across periods of dialysis and kidney transplantation may inform cancer etiology. We evaluated 202,195 kidney transplant candidates and recipients from a linkage between the Scientific Registry of Transplant Recipients and cancer registries, and compared incidence in kidney function intervals (time with a transplant) with incidence in nonfunction intervals (waitlist or time after transplant failure), adjusting for demographic factors. Incidence of infection-related and immune-related cancer was higher during kidney function intervals than during nonfunction intervals. Incidence was most elevated for Kaposi sarcoma (hazard ratio [HR], 9.1; 95% confidence interval (95% CI), 4.7 to 18), non-Hodgkin's lymphoma (HR, 3.2; 95% CI, 2.8 to 3.7), Hodgkin's lymphoma (HR, 3.0; 95% CI, 1.7 to 5.3), lip cancer (HR, 3.4; 95% CI, 2.0 to 6.0), and nonepithelial skin cancers (HR, 3.8; 95% CI, 2.5 to 5.8). Conversely, ESRD-related cancer incidence was lower during kidney function intervals (kidney cancer: HR, 0.8; 95% CI, 0.7 to 0.8 and thyroid cancer: HR, 0.7; 95% CI, 0.6 to 0.8). With each successive interval, incidence changed in alternating directions for non-Hodgkin's lymphoma, melanoma, and lung, pancreatic, and nonepithelial skin cancers (higher during function intervals), and kidney and thyroid cancers (higher during nonfunction intervals). For many cancers, incidence remained higher than in the general population across all intervals. These data indicate strong short-term effects of kidney dysfunction and immunosuppression on cancer incidence in patients with ESRD, suggesting a need for persistent cancer screening and prevention.

  16. Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study.

    Science.gov (United States)

    Quach, Hang; White, Darrell; Spencer, Andrew; Ho, P Joy; Bhutani, Divaya; White, Mike; Inamdar, Sandeep; Morris, Chris; Ou, Ying; Gyger, Martin

    2017-06-01

    The pharmacokinetics (PK) of carfilzomib have been previously studied in multiple myeloma patients with varying degrees of renal impairment (normal, mild, moderate, severe, and end-stage renal disease [ESRD]) at doses of 15 and 20 mg/m(2). This study evaluated carfilzomib PK at higher doses of 27 and 56 mg/m(2) in normal renal function and ESRD patients. Patients received carfilzomib on two consecutive days/week for 3 weeks every 28-day cycle: 20 mg/m(2) (cycle 1 day 1-2), escalated to 27 mg/m(2) on cycle 1 day 8; if tolerated, 56 mg/m(2) starting cycle 2 day 1. The primary objective was PK assessment with safety/tolerability and response rate as secondary and exploratory objectives, respectively. 26 patients were enrolled (15 normal, 11 ESRD). There was a trend toward higher area under the concentration time curve (AUC) and maximum concentration in ESRD versus normal renal function patients; however, high interpatient PK variability was discerned. Relative to patients with normal renal function, ESRD patients showed 33% higher AUC. Overall response rate was 43% for the normal renal function and 60% for the ESRD groups. Safety findings were generally similar between the two groups and consistent with the known safety profile of carfilzomib in multiple myeloma patients. There were no meaningful differences in PK between patients with normal renal function and ESRD in light of carfilzomib exposure-response relationships. These results continue to support dosing recommendation that no starting dose adjustment of carfilzomib appears warranted in patients with baseline renal impairment.

  17. Mapping End-Stage Renal Disease (ESRD): Spatial Variations on Small Area Level in Northern France, and Association with Deprivation

    Science.gov (United States)

    Occelli, Florent; Deram, Annabelle; Génin, Michaël; Noël, Christian; Cuny, Damien; Glowacki, François

    2014-01-01

    Background Strong geographic variations in the incidence of end-stage renal disease (ESRD) are observed in developed countries. The reasons for these variations are unknown. They may reflect regional inequalities in the population's sociodemographic characteristics, related diseases, or medical practice patterns. In France, at the district level, the highest incidence rates have been found in the Nord-Pas-de-Calais region. This area, with a high population density and homogeneous healthcare provision, represents a geographic situation which is quite suitable for the study, over small areas, of spatial disparities in the incidence of ESRD, together with their correlation with a deprivation index and other risk factors. Methods The Renal Epidemiology and Information Network is a national registry, which lists all ESRD patients in France. All cases included in the Nord-Pas-de-Calais registry between 2005 and 2011 were extracted. Adjusted and smoothed standardized incidence ratio (SIR) was calculated for each of the 170 cantons, thanks to a hierarchical Bayesian model. The correlation between ESRD incidence and deprivation was assessed using the quintiles of Townsend index. Relative risk (RR) and credible intervals (CI) were estimated for each quintile. Results Significant spatial disparities in ESRD incidence were found within the Nord-Pas-de-Calais region. The sex- and age-adjusted, smoothed SIRs varied from 0.66 to 1.64. Although no correlation is found with diabetic or vascular nephropathy, the smoothed SIRs are correlated with the Townsend index (RR: 1.18, 95% CI [1.00–1.34] for Q2; 1.28, 95% CI [1.11–1.47] for Q3; 1.30, 95% CI [1.14–1.51] for Q4; 1.44, 95% CI [1.32–1.74] for Q5). Conclusion For the first time at this aggregation level in France, this study reveals significant geographic differences in ESRD incidence. Unlike the time of renal replacement care, deprivation is certainly a determinant in this phenomenon. This association is probably

  18. Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study.

    Science.gov (United States)

    Guajardo, Isabella; Ayer, Amrita; Johnson, Alexander D; Ganz, Peter; Mills, Claire; Donovan, Catherine; Scherzer, Rebecca; Shah, Sanjiv J; Peralta, Carmen A; Dubin, Ruth F

    2017-03-08

    Recent studies suggest that women with end-stage renal disease (ESRD) may have higher rates of mortality than men, but it is unknown whether sex differences in vascular function explain this disparity. The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study is an ongoing, prospective observational study designed to investigate vascular function, myocardial injury, and cardiovascular outcomes in ESRD. Among 200 CERES participants (34% women), we evaluated arterial wave reflections as augmentation index normalized to a heart rate of 75 (AIx75), arterial stiffness as pulse wave velocity, and macro- and microvascular endothelial dysfunction as flow-mediated dilation and velocity time integral (VTI). Over a median of 14 months, participants were followed for the composite outcome of cardiovascular hospitalization or all-cause death. Women had higher arterial wave reflection (Mean, SD AIx75 30% ± 9% for women vs. 21% ± 10% for men; P < 0.001) and worse microvascular function (VTI 55 ± 30 cm for women vs. 70 ± 27 cm for men; P = 0.007). After multivariable adjustment, female sex remained associated with a 0.5-SD higher AIx75 (95% CI [0.01, 0.9]) and 0.3-SD lower VTI (95%CI [0.1, 0.7]). Women experienced higher adjusted rates of the composite outcome (HR 2.5; 95%CI [1.1, 5.6]; P = 0.03), and further adjustment for arterial wave reflection attenuated this risk. Vascular dysfunction may partly explain the association of female sex with higher cardiovascular risk and mortality in patients with ESRD. Further studies are needed to explore whether sex differences in vascular function predict long-term outcomes, and whether hormonal or inflammatory factors explain these associations. © 2017 International Society for Hemodialysis.

  19. 78 FR 42778 - Medicare Program; Comprehensive ESRD Care Initiative; Extension of the Submission Deadlines for...

    Science.gov (United States)

    2013-07-17

    ... beneficiaries with ESRD regarding the functional status, quality of life, and overall well-being, as well as... improve care for beneficiaries with end-stage renal disease (ESRD). To promote seamless and integrated... quality of care for this population, while lowering total per-capita expenditures under the...

  20. 78 FR 48688 - Medicare Program; Comprehensive ESRD Care Initiative; Extension of the Submission Deadlines for...

    Science.gov (United States)

    2013-08-09

    ... outcomes for beneficiaries with ESRD regarding the functional status, quality of life, and overall well... models designed to improve care for beneficiaries with end-stage renal disease (ESRD). To promote... coordination and quality of care for this population, while lowering total per-capita expenditures under...

  1. Associations of anemia persistency with medical expenditures in Medicare ESRD patients on dialysis

    Directory of Open Access Journals (Sweden)

    Jiannong Liu

    2009-04-01

    Full Text Available Jiannong Liu1, Haifeng Guo1, David Gilbertson1, Robert Foley1,2, Allan Collins1,21Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA; 2Department of Medicine, University of Minnesota, Minneapolis, MN, USAAbstract: Most end-stage renal disease (ESRD patients begin renal replacement therapy with hemoglobin levels below the recommended US National Kidney Foundation Dialysis Outcomes Quality Initiative Guidelines lower level of 110 g/L. Although most patients eventually reach this target, the time required varies substantially. This study aimed to determine whether length of time with below-target hemoglobin levels after dialysis initiation is associated with medical costs, and if so, whether intermediate factors underlie the associations. US patients initiating dialysis in 2002 were studied using the Centers for Medicare and Medicaid Services ESRD database. Anemia persistence (time in months with hemoglobin below 110 g/L was determined in a six-month entry period, and outcomes were assessed in the subsequent six-month follow-up period. The structural equation modeling technique was used to evaluate associations between persistent anemia and medical costs and to determine intermediate factors for these associations. The study included 28,985 patients. Mean per-patient-per-month medical cost was $6267 (standard deviation $5713 in the six-month follow-up period. Each additional month with hemoglobin below 110 g/L was associated with an 8.9% increment in medical cost. The increased cost was associated with increased erythropoietin use and blood transfusions, and increased rates of hospitalization and vascular access procedures in the follow-up period. Keywords: anemia persistency, end-stage renal disease, medical costs, structural equation modeling

  2. HLA class I and class II associations with ESRD in Saudi Arabian population.

    Directory of Open Access Journals (Sweden)

    Nuha Mahmoud Hamdi

    Full Text Available BACKGROUND: Chronic renal failure (CRF leads in the majority of instances to end stage renal disease (ESRD requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population. METHODOLOGY: A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated control. Patients and control groups were typed by SSOP lumenix techniques. The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50. The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03. The negatively associated haplotypes were: HLA-A*02-B*39, A*02-B*50, A*24-B*35, A*24-B*58, A*24-DRB1*16, A*68-DRB1*04, A*02-DQB1*03, A*29-DQB1*02, A*29-DOB1*05 and B*27-DRB1*07 and the last one is the most significant protective haplotypes. CONCLUSION: The high Relative Risk (RR observed and its statistical correlation reflect the strength of the described association between HLA antigens and ESRD.

  3. Benefits of a mainstreamed summer camp experience for teens with ESRD.

    Science.gov (United States)

    Klee, K M

    1992-01-01

    This is a report on a pilot project integrating children with end stage renal disease (ESRD) with well children for a summer camp experience. As the teen with ESRD prepares to enter the work force and college, he/she will have to adapt to a variety of situations that will not adapt to his/her unique medical condition. These issues motivated a pilot project in which 9 ESRD children were mainstreamed into a 2 week, YMCA summer camp experience. Pre and post questionnaires were developed and distributed to the camper, family, and the cabin counselor along with interviews to assess the value of the experience. All the children left camp more independent and knowledgeable about their self-care. The results of this pilot project indicate that children with ESRD can adapt to their environment and increase independence, self-care and self-esteem through supervised mainstreamed experiences.

  4. ESRD special needs plans: a proof of concept for integrated care.

    Science.gov (United States)

    Krishnan, Mahesh; Franco, Eric; McMurray, Stephen; Petra, Eugene; Nissenson, Allen R

    2014-11-01

    Since the completion of the Centers for Medicare and Medicaid Services' end-stage renal disease (ESRD) demonstration projects, passage of the Affordable Care Act, and announcement of ESRD Seamless Care Organizations (ESCOs) by CMS' Innovation Center, it seems that ESRD-centered accountable care organizations will be the future model for kidney care of Medicare beneficiaries. Regardless of what you call it--managed care organization, special needs plan, ESCO--balancing quality of health care with costs of health care will continue to be the primary directive for physicians and institutions using integrated care management (ICM) strategies to manage their ESRD patients' health. The renal community has had previous success with ICM, and these experiences could help to guide our way.

  5. Accumulation of advanced glycation end products and chronic complications in ESRD treated by dialysis.

    Science.gov (United States)

    Meerwaldt, Robbert; Zeebregts, Clark J; Navis, Gerjan; Hillebrands, Jan-Luuk; Lefrandt, Joop D; Smit, Andries J

    2009-01-01

    Cardiovascular and connective tissue disorders are very common in patients with end-stage renal disease (ESRD), and the accumulation of advanced glycation end products (AGEs) is significantly increased in these patients. Accumulation of AGEs is believed to have a role in tissue protein aging and the pathogenesis of such age-related diseases as diabetes and ESRD. AGEs accumulate in patients with ESRD as a result of nonenzymatic glycation, oxidative stress, and diminished clearance of AGE precursors. Some AGEs show characteristic brown pigmentation and fluorescence, form protein-protein cross-links, and may ligate with AGE-specific receptors, inducing oxidative stress and cytokine production. This review focuses on the clinical relevance of AGE accumulation in patients with ESRD treated by dialysis for the development of long-term complications. The formation and accumulation of AGEs in patients with ESRD are discussed, as well as the relationship between AGE accumulation and such major complications of ESRD as cardiovascular and connective tissue disorders.

  6. The essential of 2012 results from the French Renal Epidemiology and Information Network (REIN) ESRD registry.

    Science.gov (United States)

    Lassalle, Mathilde; Ayav, Carole; Frimat, Luc; Jacquelinet, Christian; Couchoud, Cécile

    2015-04-01

    The French Renal Epidemiology and Information Network (REIN) registry began in 2002 to provide a tool for public health decision support, evaluation and research related to renal replacement therapies (RRT) for end-stage renal disease (ESRD). It is relying on a network of nephrologists, epidemiologists, patients and public health representatives. Continuous registration covers all dialysis and transplanted patients. In 2012, in France, 10,048 patients started a RRT (154 per million inhabitants). Elders provided majority of new patients (median age at RRT start: 70 years old). New patients had a high and age increasing rate of comorbidities, especially diabetes (42% of the new patients) and cardiovascular comorbidities (>50% of the new patients). Like previous years, incidence is stabilized. On December 31, 2012, 73,491 patients were receiving a RRT in France (1127 per million inhabitants, 56% on dialysis and 44% living with a functional renal transplant). More than 50% of patients were undergoing in-center hemodialysis with significant variations among regions. An increase in medical satellite unit hemodialysis but a decrease in self-care unit hemodialysis rates were noticed across the time, whereas peritoneal dialysis remained stable at 7%. Five years after starting RRT, the overall survival rate was 51% but only 16% among patients over 85 years. Mortality rate was highly dependent on treatment and age; transplanted patients aged 60-69 had a 27/1000 patients-year mortality rate versus 133 for a dialysis patient. Patients who started dialysis had a probability of first wait-listing of 4.8% at the start of dialysis (pre-emptive registrations) and 27% at 72 months. Whatever their diabetes status was, patients older than 60 had poor access to the waiting list. Seventeen percent of the patients received a first renal transplant within 15.4 month median time; 3% had received a pre-emptive graft. Ten years after the start of the French ESRD registry, this report provides

  7. Comparative study of impact of hemodialysis and renal transplantation on cognitive functions in ESRD patients.

    Science.gov (United States)

    Anwar, Waleed; Ezzat, Haitham; Mohab, Amr

    2015-01-01

    Cognitive impairment is defined as a newly appeared deficit in at least two areas of cognitive functions, including disturbances in memory, executive functioning, attention or speed of information processing, perceptual motor abilities, or language. Cognitive impairment is highly prevalent in ESRD patients when compared with the general population. It has also been associated with a decreased quality of life. Cognitive functions in patients with ESRD showed improvement with dialysis and renal transplantation. These findings illustrate the potential importance of evaluating and comparing the effects of hemodialysis and transplantation regarding cognitive performance and thus quality of life in ESRD patients and normal subjects. This study was carried out in 100 patients (50 ESRD patients on regular hemodialysis for at least 6 months and 50 post-transplant patients who had maintained successful kidney graft for at least 3 months). All patients underwent laboratory and psychometric scoring tests, including trail making test part A, trail making test part B, digit span, and mini-mental state examination. Thirty healthy adults matched by age and sex served as a control group. The results showed significant differences in cognitive function tests results between transplant and hemodialysis patients (P0.05). Renal transplantation as a modality of treatment, in ESRD patients, is superior to hemodialysis in terms of cognitive performance improvement. Copyright © 2015 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  8. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

    Directory of Open Access Journals (Sweden)

    Carsten A Böger

    2011-09-01

    Full Text Available Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD and end stage renal disease (ESRD. Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m(2 at follow-up and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls. SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1. SNPs in UMOD (OR = 0.92, p = 0.04 and GCKR (OR = 0.93, p = 0.03 were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

  9. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

    Directory of Open Access Journals (Sweden)

    Carsten A Böger

    2011-09-01

    Full Text Available Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD and end stage renal disease (ESRD. Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m(2 at follow-up and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls. SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1. SNPs in UMOD (OR = 0.92, p = 0.04 and GCKR (OR = 0.93, p = 0.03 were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

  10. 42 CFR 413.210 - Conditions for payment under the end-stage renal disease (ESRD) prospective payment system.

    Science.gov (United States)

    2010-10-01

    ... REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING FACILITIES Payment for End-Stage Renal Disease (ESRD) Services and Organ Procurement Costs § 413.210 Conditions for payment under the end-stage renal disease (ESRD) prospective payment...

  11. 42 CFR 412.104 - Special treatment: Hospitals with high percentage of ESRD discharges.

    Science.gov (United States)

    2010-10-01

    ... established that ESRD beneficiary discharges, excluding discharges classified into MS-DRG 652 (Renal Failure), MS-DRG 682 (Renal Failure with MCC), MS-DRG 683 (Renal Failure with CC), MS-DRG 684 (Renal Failure without CC/MCC) and MS-DRG 685 (Admit for Renal Dialysis), where the beneficiary received...

  12. Accumulation of Advanced Glycation End Products and Chronic Complications in ESRD Treated by Dialysis

    NARCIS (Netherlands)

    Meerwaldt, Robbert; Zeebregts, Clark J.; Navis, Gerjan; Hillebrands, Jan-Luuk; Lefrandt, Joop D.; Smit, Andries J.

    2009-01-01

    Cardiovascular and connective tissue disorders are very common in patients with end-stage renal disease (ESRD), and the accumulation of advanced glycation end products (AGEs) is significantly increased in these patients. Accumulation of AGEs is believed to have a role in tissue protein aging and the

  13. Recovery of renal function among ESRD patients in the US medicare program.

    Directory of Open Access Journals (Sweden)

    Sumit Mohan

    Full Text Available BACKGROUND: Patients started on long term hemodialysis have typically had low rates of reported renal recovery with recent estimates ranging from 0.9-2.4% while higher rates of recovery have been reported in cohorts with higher percentages of patients with acute renal failure requiring dialysis. STUDY DESIGN: Our analysis followed approximately 194,000 patients who were initiated on hemodialysis during a 2-year period (2008 & 2009 with CMS-2728 forms submitted to CMS by dialysis facilities, cross-referenced with patient record updates through the end of 2010, and tracked through December 2010 in the CMS SIMS registry. RESULTS: We report a sustained renal recovery (i.e no return to ESRD during the available follow up period rate among Medicare ESRD patients of > 5% - much higher than previously reported. Recovery occurred primarily in the first 2 months post incident dialysis, and was more likely in cases with renal failure secondary to etiologies associated with acute kidney injury. Patients experiencing sustained recovery were markedly less likely than true long-term ESRD patients to have permanent vascular accesses in place at incident hemodialysis, while non-White patients, and patients with any prior nephrology care appeared to have significantly lower rates of renal recovery. We also found widespread geographic variation in the rates of renal recovery across the United States. CONCLUSIONS: Renal recovery rates in the US Medicare ESRD program are higher than previously reported and appear to have significant geographic variation. Patients with diagnoses associated with acute kidney injury who are initiated on long-term hemodialysis have significantly higher rates of renal recovery than the general ESRD population and lower rates of permanent access placement.

  14. Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes

    Science.gov (United States)

    Sandholm, Niina; McKnight, Amy Jayne; Salem, Rany M.; Brennan, Eoin P.; Forsblom, Carol; Harjutsalo, Valma; Mäkinen, Ville-Petteri; McKay, Gareth J.; Sadlier, Denise M.; Williams, Winfred W.; Martin, Finian; Panduru, Nicolae Mircea; Tarnow, Lise; Tuomilehto, Jaakko; Tryggvason, Karl; Zerbini, Gianpaolo; Comeau, Mary E.; Langefeld, Carl D.; Godson, Catherine; Hirschhorn, Joel N.; Maxwell, Alexander P.; Florez, Jose C.

    2013-01-01

    Sex and genetic variation influence the risk of developing diabetic nephropathy and ESRD in patients with type 1 diabetes. We performed a genome-wide association study in a cohort of 3652 patients from the Finnish Diabetic Nephropathy (FinnDiane) Study with type 1 diabetes to determine whether sex-specific genetic risk factors for ESRD exist. A common variant, rs4972593 on chromosome 2q31.1, was associated with ESRD in women (P<5×10−8) but not in men (P=0.77). This association was replicated in the meta-analysis of three independent type 1 diabetes cohorts (P=0.02) and remained significant for women (P<5×10−8; odds ratio, 1.81 [95% confidence interval, 1.47 to 2.24]) upon combined meta-analysis of the discovery and replication cohorts. rs4972593 is located between the genes that code for the Sp3 transcription factor, which interacts directly with estrogen receptor α and regulates the expression of genes linked to glomerular function and the pathogenesis of nephropathy, and the CDCA7 transcription factor, which regulates cell proliferation. Further examination revealed potential transcription factor–binding sites within rs4972593 and predicted eight estrogen-responsive elements within 5 kb of this locus. Moreover, we found sex-specific differences in the glomerular expression levels of SP3 (P=0.004). Overall, these results suggest that rs4972593 is a sex-specific genetic variant associated with ESRD in patients with type 1 diabetes and may underlie the sex-specific protection against ESRD. PMID:24029427

  15. Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification

    Directory of Open Access Journals (Sweden)

    Cai-Mei Zheng

    2011-01-01

    Full Text Available Vascular calcification is common in ESRD patients and is important in increasing mortality from cardiovascular complications in these patients. Hyperphosphatemia related to chronic kidney disease is increasingly known as major stimulus for vascular calcification. Hyperphosphatemia and vascular calcification become popular discussion among nephrologist environment more than five decades, and many researches have been evolved. Risk factors for calcification are nowadays focused for the therapeutic prevention of vascular calcification with the hope of reducing cardiovascular complications.

  16. Urgent-Start Peritoneal Dialysis and Hemodialysis in ESRD Patients: Complications and Outcomes.

    Science.gov (United States)

    Jin, Haijiao; Fang, Wei; Zhu, Mingli; Yu, Zanzhe; Fang, Yan; Yan, Hao; Zhang, Minfang; Wang, Qin; Che, Xiajing; Xie, Yuanyuan; Huang, Jiaying; Hu, Chunhua; Zhang, Haifen; Mou, Shan; Ni, Zhaohui

    2016-01-01

    Several studies have suggested that urgent-start peritoneal dialysis (PD) is a feasible alternative to hemodialysis (HD) in patients with end-stage renal disease (ESRD), but the impact of the dialysis modality on outcome, especially on short-term complications, in urgent-start dialysis has not been directly evaluated. The aim of the current study was to compare the complications and outcomes of PD and HD in urgent-start dialysis ESRD patients. In this retrospective study, ESRD patients who initiated dialysis urgently without a pre-established functional vascular access or PD catheter at a single center from January 2013 to December 2014 were included. Patients were grouped according to their dialysis modality (PD and HD). Each patient was followed for at least 30 days after catheter insertion (until January 2016). Dialysis-related complications and patient survival were compared between the two groups. Our study enrolled 178 patients (56.2% male), of whom 96 and 82 patients were in the PD and HD groups, respectively. Compared with HD patients, PD patients had more cardiovascular disease, less heart failure, higher levels of serum potassium, hemoglobin, serum albumin, serum pre-albumin, and lower levels of brain natriuretic peptide. There were no significant differences in gender, age, use of steroids, early referral to a nephrologist, prevalence of primary renal diseases, prevalence of co-morbidities, and other laboratory characteristics between the groups. The incidence of dialysis-related complications during the first 30 days was significantly higher in HD than PD patients. HD patients had a significantly higher probability of bacteremia compared to PD patients. HD was an independent predictor of short-term (30-day) dialysis-related complications. There was no significant difference between PD and HD patients with respect to patient survival rate. In an experienced center, PD is a safe and feasible dialysis alternative to HD for ESRD patients with an urgent need

  17. ESRD POST-HOSPITALIZATION ANEMIA AND ESA UTILIZATION

    Directory of Open Access Journals (Sweden)

    Alex Yang

    2012-06-01

    The majority of hospitalizations (∼2/3 had considerable post-hosp Hb drops (mean >1g/dL, with >50% permanently reduced. ∼1.5 months were needed to recover Hb, with elevated ESA doses for >2 months. ESA dose was permanently elevated in 27% of hospitalizations that recovered Hb. Strategies to address post-hosp anemia may mitigate the protracted recovery time and increased ESA use. fx1

  18. Clinical outcomes in pediatric hemodialysis patients in the USA: lessons from CMS' ESRD CPM Project.

    Science.gov (United States)

    Neu, Alicia M; Frankenfield, Diane L

    2009-07-01

    Although prospective randomized trials have provided important information and allowed the development of evidence-based guidelines in adult hemodialysis (HD) patients, with approximately 800 prevalent pediatric HD patients in the United States, such studies are difficult to perform in this population. Observational data obtained through the Center for Medicare & Medicaid Services' (CMS') End Stage Renal Disease (ESRD) Clinical Performance Measures (CPM) Project have allowed description of the clinical care provided to pediatric HD patients as well as identification of risk factors for failure to reach adult targets for clinical parameters such as hemoglobin, single-pool Kt/V (spKt/V) and serum albumin. In addition, studies linking data from the ESRD CPM Project and the United States Renal Data System have allowed evaluation of associations between achievement of those targets and the outcomes of hospitalization and death. The results of those studies, while unable to prove cause and effect, suggest that the adult ESRD CPM targets may assist in identifying pediatric HD patients at risk for poor outcomes.

  19. The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes

    National Research Council Canada - National Science Library

    Thomas, Merlin C; Moran, John; Forsblom, Carol; Harjutsalo, Valma; Thorn, Lena; Ahola, Aila; Wadén, Johan; Tolonen, Nina; Saraheimo, Markku; Gordin, Daniel; Groop, Per-Henrik

    2011-01-01

    Many guidelines recommend reduced consumption of salt in patients with type 1 diabetes, but it is unclear whether dietary sodium intake is associated with mortality and end-stage renal disease (ESRD...

  20. Comparing mandated health care reforms: the Affordable Care Act, accountable care organizations, and the Medicare ESRD program.

    Science.gov (United States)

    Watnick, Suzanne; Weiner, Daniel E; Shaffer, Rachel; Inrig, Jula; Moe, Sharon; Mehrotra, Rajnish

    2012-09-01

    In addition to extending health insurance coverage, the Affordable Care Act of 2010 aims to improve quality of care and contain costs. To this end, the act allowed introduction of bundled payments for a range of services, proposed the creation of accountable care organizations (ACOs), and established the Centers for Medicare and Medicaid Innovation to test new care delivery and payment models. The ACO program began April 1, 2012, along with demonstration projects for bundled payments for episodes of care in Medicaid. Yet even before many components of the Affordable Care Act are fully in place, the Medicare ESRD Program has instituted legislatively mandated changes for dialysis services that resemble many of these care delivery reform proposals. The ESRD program now operates under a fully bundled, case-mix adjusted prospective payment system and has implemented Medicare's first-ever mandatory pay-for-performance program: the ESRD Quality Incentive Program. As ACOs are developed, they may benefit from the nephrology community's experience with these relatively novel models of health care payment and delivery reform. Nephrologists are in a position to assure that the ACO development will benefit from the ESRD experience. This article reviews the new ESRD payment system and the Quality Incentive Program, comparing and contrasting them with ACOs. Better understanding of similarities and differences between the ESRD program and the ACO program will allow the nephrology community to have a more influential voice in shaping the future of health care delivery in the United States.

  1. Analgesics use and ESRD in younger age: a case-control study

    Directory of Open Access Journals (Sweden)

    Moehner Sabine

    2007-12-01

    Full Text Available Abstract Background An ad hoc peer-review committee was jointly appointed by Drug Authorities and Industry in Germany, Austria and Switzerland in 1999/2000 to review the evidence for a causal relation between phenacetin-free analgesics and nephropathy. The committee found the evidence as inconclusive and requested a new case-control study of adequate design. Methods We performed a population-based case-control study with incident cases of end-stage renal disease (ESRD under the age of 50 years and four age and sex-matched neighborhood controls in 170 dialysis centers (153 in Germany, and 17 in Austria from January 1, 2001 to December 31, 2004. Data on lifetime medical history, risk factors, treatment, job exposure and intake of analgesics were obtained in a standardized face-to-face interview using memory aids to enhance accuracy. Study design, study performance, analysis plan, and study report were approved by an independent international advisory committee and by the Drug Authorities involved. Unconditional logistic regression analyses were performed. Results The analysis included 907 cases and 3,622 controls who had never used phenacetin-containing analgesics in their lifetime. The use of high cumulative lifetime dose (3rd tertile of analgesics in the period up to five years before dialysis was not associated with later ESRD. Adjusted odds ratios with 95% confidence intervals were 0.8 (0.7 – 1.0 and 1.0 (0.8 – 1.3 for ever- compared with no or low use and high use compared with low use, respectively. The same results were found for all analgesics and for mono-, and combination preparations with and without caffeine. No increased risk was shown in analyses stratifying for dose and duration. Dose-response analyses showed that analgesic use was not associated with an increased risk for ESRD up to 3.5 kg cumulative lifetime dose (98 % of the cases with ESRD. While the large subgroup of users with a lifetime dose up to 0.5 kg (278 cases and

  2. The Association Between Dietary Sodium Intake, ESRD, and All-Cause Mortality in Patients With Type 1 Diabetes

    Science.gov (United States)

    Thomas, Merlin C.; Moran, John; Forsblom, Carol; Harjutsalo, Valma; Thorn, Lena; Ahola, Aila; Wadén, Johan; Tolonen, Nina; Saraheimo, Markku; Gordin, Daniel; Groop, Per-Henrik

    2011-01-01

    OBJECTIVE Many guidelines recommend reduced consumption of salt in patients with type 1 diabetes, but it is unclear whether dietary sodium intake is associated with mortality and end-stage renal disease (ESRD). RESEARCH DESIGN AND METHODS In a nationwide multicenter study (the FinnDiane Study) between 1998 and 2002, 2,807 enrolled adults with type 1 diabetes without ESRD were prospectively followed. Baseline urinary sodium excretion was estimated on a 24-h urine collection. The predictors of all-cause mortality and ESRD were determined by Cox regression and competing risk modeling, respectively. RESULTS The median follow-up for survival analyses was 10 years, during which 217 deaths were recorded (7.7%). Urinary sodium excretion was nonlinearly associated with all-cause mortality, such that individuals with the highest daily urinary sodium excretion, as well as the lowest excretion, had reduced survival. This association was independent age, sex, duration of diabetes, the presence and severity of chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] and log albumin excretion rate), the presence of established cardiovascular disease, and systolic blood pressure. During follow-up, 126 patients developed ESRD (4.5%). Urinary sodium excretion was inversely associated with the cumulative incidence of ESRD, such that individuals with the lowest sodium excretion had the highest cumulative incidence of ESRD. CONCLUSIONS In patients with type 1 diabetes, sodium was independently associated with all-cause mortality and ESRD. Although we have not demonstrated causality, these findings support the calls for caution before applying salt restriction universally. Clinical trials must be performed in diabetic patients to formally test the utility/risk of sodium restriction in this setting. PMID:21307382

  3. Effects of Cinacalcet and Concurrent Low-Dose Vitamin D on FGF23 Levels in ESRD

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    Liu, Shiguang; Krebill, Ron; Menard, Rochelle; Quarles, L. Darryl

    2010-01-01

    Background and objectives: Fibroblast growth factor-23 (FGF23) levels are elevated in ESRD and have been associated with adverse outcomes. The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial. Design, setting, participants, & measurements: We assessed intact FGF23 levels in 91 subjects over the course of the ACHIEVE trial, which was designed to compare escalating doses of Cinacalcet plus fixed low-dose calcitriol analogs (Cinaclcet-D) with titration of calcitriol analogs alone (Flex-D) to suppress parathyroid hormone. Between-group and within-group changes in log-transformed FGF23 levels were analyzed. Factors associated with change in FGF23 were assessed using a multiple regression model. Results: Intact FGF23 levels were markedly elevated in subjects at baseline. A statistically significant difference in percent change in log FGF23 levels was observed between treatment groups (P < 0.002). The Cinacalcet-D group had a significant decrease in percent change in log FGF23 levels (corrected P = 0.021), whereas FGF23 levels trended toward an increase in the Flex-D group. Change in FGF23 level was significantly associated with changes in levels of phosphate (P < 0.0001) and calcium (P = 0.0002) but not parathyroid hormone. Conclusions: Treatment with Cinacalcet plus low-dose calcitriol analogs results in lower FGF23 levels compared with a treatment regimen using calcitriol analogs alone in ESRD. The mechanisms underlying the differential effects of these treatment regimens on FGF23 levels and the clinical impact of these changes on FGF23 remain to be defined. PMID:19965548

  4. ESRD in the geriatric population: the crisis of managed care and the opportunity of disease management.

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    Steinman, Theodore I

    2002-01-01

    The geriatric population with end-stage renal disease (ESRD) is placed at risk with regards to the quality and extent of medical coverage because of the rapidly changing financial environment. Managed care organizations (MCOs) are generally for-profit companies that must focus on the bottom line. While the verbal commitment to quality care is voiced, the financial pressures on MCOs have led to a decrease in coverage of many services and outright denial for some necessary treatments. While denying services, the MCOs have also reduced payments to providers for services rendered. The coverage crisis is compounded by health maintenance organizations (HMOs) quitting Medicare because the reimbursement from the Health Care Financing Administration (HCFA) is less than their costs. Because of the above issues which can potentially impact on the quality of care delivered to the ESRD geriatric population, a new approach to disease management has created the opportunity to improve total patient care to a level not yet achieved in the United States. Disease management encompasses integrated care across all disciplines. Every component of care can be tracked by a dedicated information system. Improvement in outcomes has far exceeded the U.S. Renal Data System (USRDS) benchmark performance measurements with a disease management model approach. The key to success is the health service coordinator (HSC), a senior nurse with many years of ESRD experience. This individual coordinates care across all disciplines and expedites necessary referrals. With rapid attention to patient needs there has been a significant reduction in hospital admissions, hospital length of stay, and emergency room visits. Patient care will steadily improve as the disease management system matures as a consequence of understanding the patients total physical and psychosocial needs.

  5. Kidney transplantation in undocumented immigrants with ESRD: a policy whose time has come?

    Science.gov (United States)

    Linden, Ellena A; Cano, Jeannette; Coritsidis, George N

    2012-09-01

    In most US states, taxpayers are paying, either directly or indirectly, for years of dialysis therapy for undocumented immigrants with end-stage renal disease who lack resources to pay for care themselves. Living donor transplant is a less expensive long-term alternative, but it is unknown what percentage of these patients have potential living donors. We conducted a cross-sectional survey of undocumented immigrant patients receiving dialysis at our outpatient center between March and May 2010. Forty-five patients completed the survey. The survey focused on the availability of potential living donors, perceived health status of those donors, and potential recipients' outlook on remaining on dialysis therapy versus receiving a kidney transplant. We gathered demographic and health status data for the survey participants and the 82 documented resident patients receiving care in the same dialysis unit. The average age of our undocumented immigrant patients was 44 years. The undocumented patients were healthier than their legal resident counterparts, with a lower incidence of coronary artery disease (7% vs 33%; P undocumented immigrants were working when they were surveyed. Of the half who had stopped working, 82% said they would seek work if they had a kidney transplant. 60% had at least one potential kidney donor. Most donors were reported to reside in the United States or Canada. Undocumented immigrants treated with dialysis in the United States are relatively young and healthy, and many have at least one potential living kidney donor. Given the societal cost-savings associated with transplant, we suggest that policy makers should consider extending coverage to pay for living donor transplant for undocumented immigrants with end-stage renal disease. Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  6. Relative Incidence of ESRD Versus Cardiovascular Mortality in Proteinuric Type 2 Diabetes and Nephropathy : Results From the DIAMETRIC (Diabetes Mellitus Treatment for Renal Insufficiency Consortium) Database

    NARCIS (Netherlands)

    Packham, David K.; Alves, Tahira P.; Dwyer, Jamie P.; Atkins, Robert; de Zeeuw, Dick; Cooper, Mark; Shahinfar, Shahnaz; Lewis, Julia B.; Lambers Heerspink, Hiddo J.

    2012-01-01

    Background: Previous studies have shown that patients with chronic kidney disease, including those with diabetic nephropathy, are more likely to die of cardiovascular disease than reach end-stage renal disease (ESRD). This analysis was conducted to determine whether ESRD is a more common outcome tha

  7. Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD.

    Science.gov (United States)

    Kramann, Rafael; Erpenbeck, Johanna; Schneider, Rebekka K; Röhl, Anna B; Hein, Marc; Brandenburg, Vincent M; van Diepen, Merel; Dekker, Friedo; Marx, Nicolaus; Floege, Jürgen; Becker, Michael; Schlieper, Georg

    2014-10-01

    Cardiovascular mortality is high in ESRD, partly driven by sudden cardiac death and recurrent heart failure due to uremic cardiomyopathy. We investigated whether speckle-tracking echocardiography is superior to routine echocardiography in early detection of uremic cardiomyopathy in animal models and whether it predicts cardiovascular mortality in patients undergoing dialysis. Using speckle-tracking echocardiography in two rat models of uremic cardiomyopathy soon (4-6 weeks) after induction of kidney disease, we observed that global radial and circumferential strain parameters decreased significantly in both models compared with controls, whereas standard echocardiographic readouts, including fractional shortening and cardiac output, remained unchanged. Furthermore, strain parameters showed better correlations with histologic hallmarks of uremic cardiomyopathy. We then assessed echocardiographic and clinical characteristics in 171 dialysis patients. During the 2.5-year follow-up period, ejection fraction and various strain parameters were significant risk factors for cardiovascular mortality (primary end point) in a multivariate Cox model (ejection fraction hazard ratio [HR], 0.97 [95% confidence interval (95% CI), 0.95 to 0.99; P=0.012]; peak global longitudinal strain HR, 1.17 [95% CI, 1.07 to 1.28; P<0.001]; peak systolic and late diastolic longitudinal strain rates HRs, 4.7 [95% CI, 1.23 to 17.64; P=0.023] and 0.25 [95% CI, 0.08 to 0.79; P=0.02], respectively). Multivariate Cox regression analysis revealed circumferential early diastolic strain rate, among others, as an independent risk factor for all-cause mortality (secondary end point; HR, 0.43; 95% CI, 0.25 to 0.74; P=0.002). Together, these data support speckle tracking as a postprocessing echocardiographic technique to detect uremic cardiomyopathy and predict cardiovascular mortality in ESRD.

  8. CCR5 Delta 32 Genotype Leads to a Th2 Type Directed Immune Response in ESRD Patients

    NARCIS (Netherlands)

    Muntinghe, Friso L. H.; Abdulahad, Wayel H.; Huitema, Minke G.; Damman, Jeffrey; Seelen, Marc A.; Lems, Simon P. M.; Hepkema, Bouke G.; Navis, Gerjan; Westra, Johanna

    2012-01-01

    Background: In patients with end stage renal disease (ESRD) we observed protection from inflammation-associated mortality in CCR5 Delta 32 carriers, leading to CCR5 deficiency, suggesting impact of CCR5 Delta 32 on inflammatory processes. Animal studies have shown that CCR5 deficiency is associated

  9. Development of a behavioural self-regulation intervention to improve employment, autonomy and self-esteem in ESRD patients.

    NARCIS (Netherlands)

    Jansen, D.; Heijmans, M.; Rijken, M.

    2008-01-01

    Background: The aim was to develop a psychological intervention for ESRD patients and their partners aimed at maintaining/widening patients’ daily activities including work, and increasing patients’ autonomy and self-esteem. Methods: The intervention was based on self-regulation theory, social learn

  10. 42 CFR 413.220 - Methodology for calculating the per-treatment base rate under the ESRD prospective payment system...

    Science.gov (United States)

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE... Disease (ESRD) Services and Organ Procurement Costs § 413.220 Methodology for calculating the per... factor to account for the most recent estimate of increases in the prices of an appropriate market...

  11. The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients

    Science.gov (United States)

    Cerrillos-Gutiérrez, José Ignacio; Preciado-Rojas, Priscila; Gómez-Navarro, Benjamín; Sifuentes-Franco, Sonia; Carrillo-Ibarra, Sandra; Andrade-Sierra, Jorge; Rojas-Campos, Enrique; Cueto-Manzano, Alfonso Martín

    2016-01-01

    Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD). Objective. To determine the effect of RT on the evolution of oxidative DNA status. Methods. Prospective cohort (N = 50 receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-DNA-N- glycosylase-1 (hOGG1); and antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPx), were evaluated. Results. Before RT, 8-OHdG were significantly elevated (11.04 ± 0.90 versus 4.73 ± 0.34 ng/mL) compared to healthy controls (p = 0.001), with normalization after 6 months of 4.78 ± 0.34 ng/mL (p < 0.001). The same phenomenon was observed with hOGG1 enzyme before RT with 2.14 ± 0.36 ng/mL (p = 0.01) and decreased significantly at the end of the study to 1.20 ng/mL (p < 0.001) but was higher than controls, 0.51 ± 0.07 ng/mL (p < 0.03). Antioxidant SOD was elevated at 24.09 ± 1.6 IU/mL versus healthy controls (p = 0.001) before RT; however, 6 months after RT it decreased significantly to 16.9 ± 1.6 IU/mL (p = 0.002), without achieving the levels of healthy controls (p = 0.01). The GPx, before RT, was significantly diminished with 24.09 ± 1.6 IU/mL versus healthy controls (39.0 ± 1.58) (p = 0.01), while, in the final results, levels increased significantly to 30.38 ± 3.16 IU/mL (p = 0.001). Discussion. Patients with ESRD have important oxidative damage before RT. The RT significantly reduces oxidative damage and partially regulates the antioxidant enzymes (SOD and GPx). PMID:27547292

  12. Is kidney function affecting the management of myocardial infarction? A retrospective cohort study in patients with normal kidney function, chronic kidney disease stage III–V, and ESRD

    Directory of Open Access Journals (Sweden)

    Saad M

    2016-01-01

    Full Text Available Marc Saad,1 Boutros Karam,1 Geovani Faddoul,2 Youssef El Douaihy,1 Harout Yacoub,1 Hassan Baydoun,3 Christine Boumitri,1 Iskandar Barakat,1 Chadi Saifan,4 Elie El-Charabaty,4 Suzanne El Sayegh4 1Department of Internal Medicine, Staten Island University Hospital, Staten Island, 2Department of Nephrology, Icahn School of Medicine, New York, NY, 3Department of Cardiology, Tulane University Medical Center, New Orleans, LA, 4Department of Nephrology, Staten Island University Hospital, Staten Island, NY, USA Abstract: Patients with chronic kidney disease (CKD are three times more likely to have myocardial infarction (MI and suffer from increased morbidity and higher mortality. Traditional and unique risk factors are prevalent and constitute challenges for the standard of care. However, CKD patients have been largely excluded from clinical trials and little evidence is available to guide evidence-based treatment of coronary artery disease in patients with CKD. Our objective was to assess whether a difference exists in the management of MI (ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction among patients with normal kidney function, CKD stage III–V, and end-stage renal disease (ESRD patients. We conducted a retrospective cohort study on patients admitted to Staten Island University Hospital for the diagnosis of MI between January 2005 and December 2012. Patients were assigned to one of three groups according to their kidney function: Data collected on the medical management and the use of statins, platelet inhibitors, beta-blockers, and angiotensin converting enzyme inhibitors/angiotensin receptor blockers were compared among the three cohorts, as well as medical interventions including: catheterization and coronary artery bypass graft (CABG when indicated. Chi-square test was used to compare the proportions between nominal variables. Binary logistic analysis was used in order to determine associations

  13. Sleep quality, mood, alertness and their variability in CKD and ESRD.

    Science.gov (United States)

    Roumelioti, Maria-Eleni; Argyropoulos, Christos; Buysse, Daniel J; Nayar, Harry; Weisbord, Steven D; Unruh, Mark L

    2010-01-01

    Little is known about the association of chronic kidney disease (CKD) with sleep quality, mood, and alertness. In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease. Patients were recruited from local dialysis units, outpatient nephrology clinics and the Thomas E. Starzl Transplant Institute. Healthy control subjects matched for age, gender and race were drawn from an archival database. Daily symptoms of sleep quality, mood, and alertness were assessed by visual analogue scales of the Pittsburgh Sleep Diary. Health-related quality of life was assessed by the Short Form-36 instrument. Sixty-nine dialysis patients and 23patients with advanced CKD demonstrated worse scores in sleep quality, mood, and alertness (p < 0.001) than controls. In adjusted analyses, European-American race, dialysis dependency, younger age, and physical performance SF-36 components were significantly associated with poor sleep quality, mood and alertness (p < 0.05). The dialysis population demonstrated higher day-to-day variability in scores than either the advanced CKD patients or the controls. Advanced CKD and dialysis dependency are associated with impaired and highly variable sleep quality, mood, and alertness. Copyright 2010 S. Karger AG, Basel.

  14. Single-center open-label randomized study of anemia management improvement in ESRD patients with secondary hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Bellasi Antonio

    2016-04-01

    Full Text Available Whether anemia and mineral bone abnormalities (chronic kidney disease–mineral bone disorder [CKD-MBD] are associated still remains to be elucidated. Both anemia and CKD-MBD have been associated with adverse cardiovascular outcome and poor quality of life. However, recent evidence suggests that use of large doses of erythropoietin-stimulating agents (ESAs to correct hemoglobin (Hb may be detrimental in CKD. The Optimal Anemia Treatment in End Stage Renal Disease (ESRD (Optimal ESRD Treatment study will assess whether lowering of parathyroid hormone (PTH is associated with a reduction in ESA consumption. The Optimal ESRD Treatment study is a pilot single-center open-label study with blinded end point (a prospective randomized open blinded end-point [PROBE] design enrolling 50 patients on maintenance dialysis. Eligible patients with intact PTH (iPTH 300-540 pg/mL and Hb 10-11.5 g/dL will be randomized 1:1 to strict PTH control (150-300 pg/mL versus standard care (PTH range 300-540 pg/mL. Available drugs for CKD-MBD and anemia treatment will be managed by the attending physician to maintain the desired levels of PTH (according to study arm allocation and Hb (10-11.5 g/dL. Echocardiographic data for cardiac structure and function as well as arterial stiffness will be assessed at study inception and completion. The Optimal ESRD Treatment study should shed light on the complicated interplay of anemia and CKD-MBD and on the feasibility of clinical trials in this domain. The study results are expected in the spring of 2017.

  15. Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy

    Directory of Open Access Journals (Sweden)

    Cheng-Hsu Chen

    2014-01-01

    Full Text Available Idiopathic membranous nephropathy (MN is one of the most common causes of nephrotic syndrome in adults, and 25% of MN patients proceed to ESRD. Urokinase plasminogen activator (uPA may play an important role in reducing renal fibrosis. This study was conducted to clarify the relationship between uPA gene polymorphisms and clinical manifestations of MN. We recruited 91 biopsy-diagnosed MN patients and 105 healthy subjects. Genotyping of uPA gene 3′-UTR T/C polymorphism was performed by polymerase chain reaction methods. The genotype distribution had no effect on the development of MN. Thirteen patients (15.9%; P=0.008 acquired malignancies and seventeen (20.7%; P=0.006 patients progressed to ESRD with the C/C genotype, but no patients with the T/C genotype did. In conclusion, we demonstrated that the presence of the uPA gene 3′-UTR C/C genotype was associated with ESRD as well as acquired malignancies in MN patients. These findings should prompt specific considerations for the treatment of MN patients to maintain a balance between treating disease entities and protecting the immune system from cancers.

  16. Serum albumin as predictor of nutritional status in patients with ESRD.

    Science.gov (United States)

    Gama-Axelsson, Thiane; Heimbürger, Olof; Stenvinkel, Peter; Bárány, Peter; Lindholm, Bengt; Qureshi, Abdul Rashid

    2012-09-01

    Serum albumin is a widely used biomarker of nutritional status in patients with CKD; however, its usefulness is debated. This study investigated serum albumin and its correlation with several markers of nutritional status in incident and prevalent dialysis patients. In a cross sectional study, serum albumin (bromocresol purple), and other biochemical (serum creatinine), clinical (subjective global assessment [SGA]), anthropometric (handgrip strength, skinfold thicknesses), and densitometric (dual energy x-ray absorptiometry) markers of nutritional status were assessed in 458 incident (61% male; mean age 54 +/- 13 years; GFR, 6.6 +/-2.3 ml/min per 1.73 m(2); recruited 1994–2010) and 383 prevalent (56% male; mean age 62 +/- 14 years; recruited 1989–2004) dialysis patients. In incident patients: serum albumin was correlated with sex (beta = -0.13; P = 0.02), diabetes mellitus (beta = -0.18; P = 0.004), and urinary albumin excretion (beta = -0.42; P = 0.001) but less so with poor nutritional status (SGA score >1; beta = -0.19; P = 0.001). In prevalent patients, serum albumin was correlated with age (beta = -0.14; P = 0.05), high-sensitivity C-reactive protein (beta = -0.34; P = 0.001), diabetes mellitus (beta = -0.11; P = 0.04), and SGA score >1 (beta = -0.14; P = 0.003). In predicting nutritional status assessed by SGA and other markers, adding serum albumin to models that included age, sex, diabetes, and cardiovascular disease did not significantly increase explanatory power. In incident and prevalent dialysis patients,serum albumin correlates poorly with several markers of nutritional status. Thus, its value as a reliable marker of nutritional status in patients with ESRD is limited. In addition, the following inconsistencies between the main text and Tables 1 and 3 are also corrected as follows. (1) In Table 1, the GFR initially written as 6 +/- 3 ml/min per 1.73(2) should be corrected to 6.6 +/- 2.3 ml/min per 1.73(2). (2) On line 11 of page 1448, under the

  17. Healthy Dietary Patterns and Risk of Mortality and ESRD in CKD: A Meta-Analysis of Cohort Studies.

    Science.gov (United States)

    Kelly, Jaimon T; Palmer, Suetonia C; Wai, Shu Ning; Ruospo, Marinella; Carrero, Juan-Jesus; Campbell, Katrina L; Strippoli, Giovanni F M

    2017-02-07

    Patients with CKD are advised to follow dietary recommendations that restrict individual nutrients. Emerging evidence indicates overall eating patterns may better predict clinical outcomes, however, current data on dietary patterns in kidney disease are limited. This systematic review aimed to evaluate the association between dietary patterns and mortality or ESRD among adults with CKD. Medline, Embase, and reference lists were systematically searched up to November 24, 2015 by two independent review authors. Eligible studies were longitudinal cohort studies reporting the association of dietary patterns with mortality, cardiovascular events, or ESRD. A total of seven studies involving 15,285 participants were included. Healthy dietary patterns were generally higher in fruit and vegetables, fish, legumes, cereals, whole grains, and fiber, and lower in red meat, salt, and refined sugars. In six studies, healthy dietary patterns were consistently associated with lower mortality (3983 events; adjusted relative risk, 0.73; 95% confidence interval, 0.63 to 0.83; risk difference of 46 fewer (29-63 fewer) events per 1000 people over 5 years). There was no statistically significant association between healthy dietary patterns and risk of ESRD (1027 events; adjusted relative risk, 1.04; 95% confidence interval, 0.68 to 1.40). Healthy dietary patterns are associated with lower mortality in people with kidney disease. Interventions to support adherence to increased fruit and vegetable, fish, legume, whole grain, and fiber intake, and reduced red meat, sodium, and refined sugar intake could be effective tools to lower mortality in people with kidney disease. Copyright © 2017 by the American Society of Nephrology.

  18. Do HDL and LDL subfractions play a role in atherosclerosis in end-stage renal disease (ESRD) patients?

    Science.gov (United States)

    Gluba-Brzózka, Anna; Franczyk, Beata; Banach, Maciej; Rysz-Górzyńska, Magdalena

    2017-01-01

    Significantly increased cardiovascular mortality in patients with chronic kidney (CKD) disease cannot be explained by traditional risk factors. Recent studies revealed that the quality of HDL and LDL cholesterol may be more important than their serum levels. The aim of this study was to assess which LDL and HDL subfractions were more abundant in end-stage renal disease (ESRD) patients and to analyse whether subfraction distribution could be associated with accelerated atherosclerotic processes. This study included 50 ESRD patients undergoing dialysis and 20 healthy volunteers. LDL and HDL subfractions were analysed in serum with the use of Lipoprint system. All patients had intima-media thickness (IMT) measured. Statistically significant differences in subfractions between control and study group were observed in case of: HDL1 (p HDL2 (p = 0.009), HDL3 (p HDL4 (p = 0.003), HDL5 (p = 0.01), HDL7 (p HDL8 (p HDL9 (p HDL10 (p HDL (p HDL Small (p HDL and LDL subfraction distribution between haemodialysis patients with normal and increased IMT: HDL6 (p = 0.020), HDL Large (HDL1-3) (p = 0.017), HDL Intermediate (HDL4-7) (p = 0.017). This study revealed that ESRD influenced HDL subfractions. In HD patients, large HDL subfractions are more abundant while small HDL fraction is more frequent in healthy persons. It failed to show the influence of end-stage disease on LDL subfraction levels. Shift in HDL subfractions might be responsible for the increased risk of atherosclerosis in CKD patients.

  19. Human Evaluation of the Glu298Asp Polymorphism in NOS3 Gene and its Relationship with Onset age of ESRD in Iranian Patients Suffering from ADPKD.

    Science.gov (United States)

    Dasar, Negin; Ghaderian, Sayyed Mohammad Hossein; Azargashb, Eznollah

    2012-01-01

    One of the most striking features in autosomal dominant polycystic kidney disease (ADPKD) is the difference at onset age of end-stage renal disease (ESRD). Modifier genes may play a role in this phenotypic variability. The mutated nitric oxide synthase 3 gene (NOS3), have a modifier effect on the severity of ADPKD by impairment of NOS3 activity and decreasing of renal vascular nitric oxide production and, subsequently, reduced kidney function. In order to test this hypothesis, we investigated the relationship between Glu298Asp polymorphism in exon 7 of this gene and ESRD in ADPKD patients refered from Shahid Labbafi Nedjad Hospital in Tehran. The polymorphism was examined by PCR, followed by RFLP (with MboI) in three groups of ADPKD with ESRD; ADPKD without ESRD patients and normal individual as the cases, case-controls and controls, respectively. The frequencies of GG, GT, and TT genotypes in cases were 66.7%, 33.3% and 0%, in case-controls were 78.6%, 19%, 2.4%, and in controls were 64.3%, 35.7% and 0%, respectively. Our findings revealed that there was no significant difference in the genotype frequency of NOS3 gene in ADPKD patients (p=0.311).The age of onset of ESRD in ADPKD patients, harbouring the T allele of this polymorphism, was two years lower than G/G patients, but this difference was not significant (p =0.641). In conclusion, our results suggest that there is no evidence of relationship between Glu298Asp polymorphism and onset age of ESRD in Iranian ADPKD patients.

  20. Dietary Patterns and Risk of Death and Progression to ESRD in Individuals With CKD: A Cohort Study

    Science.gov (United States)

    Gutiérrez, Orlando M.; Muntner, Paul; Rizk, Dana V.; McClellan, William M.; Warnock, David G.; Newby, P.K.; Judd, Suzanne E.

    2014-01-01

    Background Nutrition is strongly linked with health outcomes in chronic kidney disease (CKD). However, few studies have examined relationships between dietary patterns and health outcomes in persons with CKD. Study Design Observational cohort study. Setting & Participants 3,972 participants with CKD (defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2 or an albumin-creatinine ratio ≥30 mg/g at baseline) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a prospective cohort study of 30,239 black and white adults at least 45 years of age. Predictors Five empirically derived dietary patterns identified via factor analysis: “Convenience” (Chinese and Mexican foods, pizza, other mixed dishes), “Plant-Based” (fruits, vegetables), “Sweets/Fats” (sugary foods), “Southern” (fried foods, organ meats, sweetened beverages), and “Alcohol/Salads” (alcohol, green-leafy vegetables, salad dressing). Outcomes All-cause mortality and end-stage renal disease (ESRD). Results A total of 816 deaths and 141 ESRD events were observed over approximately 6 years of follow-up. There were no statistically significant associations of Convenience, Sweets/Fats or Alcohol/Salads pattern scores with all-cause mortality after multivariable adjustment. In Cox regression models adjusted for sociodemographic factors, energy intake, co-morbidities, and baseline kidney function, higher Plant-Based pattern scores (indicating greater consistency with the pattern) were associated with lower risk of mortality (HR comparing fourth to first quartile, 0.77; 95%CI, 0.61–0.97) whereas higher Southern pattern scores were associated with greater risk of mortality (HR comparing fourth to first quartile, 1.51; 95%CI, 1.19–1.92). There were no associations of dietary patterns with incident ESRD in multivariable-adjusted models. Limitations Missing dietary pattern data, potential residual confounding from lifestyle factors. Conclusions A

  1. Introduction of a cyclophosphamide-based treatment strategy and the risk of ESRD in patients with idiopathic membranous nephropathy: a nationwide survey in the Netherlands.

    NARCIS (Netherlands)

    Hofstra, J.M.; Wetzels, J.F.M.

    2008-01-01

    BACKGROUND: The efficacy of immunosuppressive therapy in preventing ESRD in patients with idiopathic membranous nephropathy (iMN) is debated. From 1991 onwards, we have advocated a restrictive treatment strategy in our university hospital and regional referring hospitals. We advised the use of immun

  2. Extreme Levels of HbA1c Increase Incident ESRD Risk in Chinese Patients with Type 2 Diabetes: Competing Risk Analysis in National Cohort of Taiwan Diabetes Study.

    Directory of Open Access Journals (Sweden)

    Li-Na Liao

    Full Text Available Whether HbA1c is a predictor of end-stage renal disease (ESRD in type 2 diabetes patients remains unclear. This study evaluated relationship between HbA1c and ESRD in Chinese patients with type 2 diabetes.Patients aged ≥ 30 years who were free of ESRD (n = 51 681 were included from National Diabetes Care Management Program from 2002-2003. Extended Cox proportional hazard model with competing risk of death served to evaluate association between HbA1c level and ESRD.A total of 2613 (5.06% people developed ESRD during a follow-up period of 8.1 years. Overall incidence rate of ESRD was 6.26 per 1000 person-years. Patients with high levels of HbA1c had a high incidence rate of ESRD, from 4.29 for HbA1c of  6.0%-6.9% to 10.33 for HbA1c ≥ 10.0% per 1000 person-years. Patients with HbA1c < 6.0% particularly had a slightly higher ESRD incidence (4.34 per 1000 person-years than those with HbA1c  of 6.0%-6.9%. A J-shaped relationship between HbA1c level and ESRD risk was observed. After adjustment, patients with HbA1c < 6.0% and ≥ 10.0% exhibited an increased risk of ESRD (HR: 1.99, 95% CI: 1.62-2.44; HR: 4.42, 95% CI: 3.80-5.14, respectively compared with those with HbA1c of 6.0%-6.9%.Diabetes care has focused on preventing hyperglycemia, but not hypoglycemia. Our study revealed that HbA1c level ≥ 7.0% was linked with increased ESRD risk in type 2 diabetes patients, and that HbA1c < 6.0% also had the potential to increase ESRD risk. Our study provides epidemiological evidence that appropriate glycemic control is essential for diabetes care to meet HbA1c targets and improve outcomes without increasing the risk to this population. Clinicians need to pay attention to HbA1c results on diabetic nephropathy.

  3. Progression of stages 3b–5 chronic kidney disease—Preliminary results of Taiwan National Pre-ESRD Disease Management Program in Southern Taiwan

    Directory of Open Access Journals (Sweden)

    Chun-Mei Lin

    2013-12-01

    Conclusion: Even though we cannot conclude with certainty that the Taiwan pre-ESRD disease management program is beneficial in slowing the progression of CKD stages 3b–5, our preliminary results seem to suggest this trend. Furthermore, the program may be improved by integrating it with other programs, such as those on diabetes and hypertension, thus making it a more patient-centered, multidisciplinary program.

  4. Tough choices: dialysis, palliative care, or a third option for elderly ESRD.

    Science.gov (United States)

    Williams, Mark E

    2012-01-01

    Dialysis should not be presumed to be the treatment of choice for all elderly chronic kidney disease stage 5 patients. Nondialysis active medical management, as an alternative to dialysis or palliative care, is a reasonable alternative in select cases. Early referral of CKD 5 elderly patients may lead to early initiation of dialysis, which may not be advantageous; it also provides an opportunity to institute active management as a treatment alternative. The informed decision to proceed with dialysis must involve both an assessment of evidence-based outcomes applicable to the patient, and allowance of patient preference. Prognostic tools are increasingly sought to aid in decision-making for elderly CKD 5 patients. Chronological age alone is not a sufficient predictor of benefit from dialysis treatments, according to observational studies and limited clinical trial data. The survival advantage of dialysis appears to be lost in patients with high levels of comorbidity. Establishing patient preference is an imperfect process, and many patients appear to regret their decision to undergo dialysis. With active medical management, efforts shift from prolonging life to emphasis on symptom control, dietary and medical treatment, and quality of life. Patient survival time can be remarkably long.

  5. Ferric Citrate Reduces Intravenous Iron and Erythropoiesis-Stimulating Agent Use in ESRD

    Science.gov (United States)

    Jalal, Diana I.; Greco, Barbara A.; Umeukeje, Ebele M.; Reisin, Efrain; Manley, John; Zeig, Steven; Negoi, Dana G.; Hiremath, Anand N.; Blumenthal, Samuel S.; Sika, Mohammed; Niecestro, Robert; Koury, Mark J.; Ma, Khe-Ni; Greene, Tom; Lewis, Julia B.; Dwyer, Jamie P.

    2015-01-01

    Ferric citrate (FC) is a phosphate binder with shown efficacy and additional effects on iron stores and use of intravenous (iv) iron and erythropoiesis-stimulating agents (ESAs). We provide detailed analyses of changes in iron/hematologic parameters and iv iron/ESA use at time points throughout the active control period of a phase 3 international randomized clinical trial. In all, 441 subjects were randomized (292 to FC and 149 to sevelamer carbonate and/or calcium acetate [active control (AC)]) and followed for 52 weeks. Subjects on FC had increased ferritin and transferrin saturation (TSAT) levels compared with subjects on AC by week 12 (change in ferritin, 114.1±29.35 ng/ml; Piron compared with subjects on AC over 52 weeks (median [interquartile range] dose=12.9 [1.0–28.9] versus 26.8 [13.4–47.6] mg/wk; Piron was higher with FC (Piron parameters apparent after 12 weeks and reduces iv iron and ESA use while maintaining hemoglobin over 52 weeks, with a safety profile similar to that of available binders. PMID:25736045

  6. ESRD - General Information Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — This page presents Public Use Files and other publicly-available data on CMS End-Stage Renal Disease Program. The focus is on the congressionally mandated Program...

  7. Empowering Esrd Patients For Assisted Self Nutritional Care: A Simple But Effective Intervention For Improving Nutritional Status Of Hemodialysis Patients

    Directory of Open Access Journals (Sweden)

    Pratim Sengupta

    2012-06-01

    Full Text Available Protein energy wasting (PEW is a prevalent problem among hemodialysis patients. Lack of adherence to dietary principle based conventional diet charts often fail to satisfy the nutritional requirements of the patients. We studied the effect of simple nutritional training and empowerment of the patients to formulate their own dietary menu in nutritional parameters of hemodialysis patients in 68 stable non diabetic End stage renal disease (ESRD patients who are on maintenance hemodialysis. The factors which otherwise can affect the nutritional status like sepsis, malignancy,tuberculosis were excluded. At the beginning patient's baseline nutritional status was assessed by anthropometric measurements, Subjective Global Assessment and serum albumin level. Body composition was assessed by linear regression equation (Durin-Womersley and Siri equation. The patients were divided in two comparable groups (Group-A&B. In group A patients were prescribed individualized dietary prescription; based on their nutritional allowance as per KDOQI guideline. In Group-B the patients were initially made familiar with the dietary principals of the commonly consumed food. Then they were trained by renal nutritionist by study material, visual aid, and proportional food models and one to one discussion to formulate a dietary menu, by these they were empowered to formulate their own dietary menu. They were constantly assisted when faced any problem. In both the group the nutritional parameters were reassessed after three months of intervention. The results were analyzed statistically. There was statistically significant mean increment in the fat free mass index in GroupB[0.8%(Gr.-AVs1.0%(Gr.-B,(p<0.05], the mean increment in the serum albumin in the GroupB was also significantly higher than GroupA[(0.6gm/dl(Gr.A Vs 0.9 gm/dl(Gr.B, p<0.0].Compared to Group-A there was statistically favorable anthropometric changes in Group-B. In conclusion patient empowerment and self

  8. Variation in infection prevention practices in dialysis facilities: results from the national opportunity to improve infection control in ESRD (End-Stage Renal Disease) project.

    Science.gov (United States)

    Chenoweth, Carol E; Hines, Stephen C; Hall, Kendall K; Saran, Rajiv; Kalbfleisch, John D; Spencer, Teri; Frank, Kelly M; Carlson, Diane; Deane, Jan; Roys, Erik; Scholz, Natalie; Parrotte, Casey; Messana, Joseph M

    2015-07-01

    OBJECTIVE To observe patient care across hemodialysis facilities enrolled in the National Opportunity to Improve Infection Control in ESRD (end-stage renal disease) (NOTICE) project in order to evaluate adherence to evidence-based practices aimed at prevention of infection. SETTING AND PARTICIPANTS Thirty-four hemodialysis facilities were randomly selected from among 772 facilities in 4 end-stage renal disease participating networks. Facility selection was stratified on dialysis organization affiliation, size, socioeconomic status, and urban/rural status. MEASUREMENTS Trained infection control evaluators used an infection control worksheet to observe 73 distinct infection control practices at the hemodialysis facilities, from October 1, 2011, through January 31, 2012. RESULTS There was considerable variation in infection control practices across enrolled facilities. Overall adherence to recommended practices was 68% (range, 45%-92%) across all facilities. Overall adherence to expected hand hygiene practice was 72% (range, 10%-100%). Compliance to hand hygiene before and after procedures was high; however, during procedures hand hygiene compliance averaged 58%. Use of chlorhexidine as the specific agent for exit site care was 19% overall but varied from 0% to 35% by facility type. The 8 checklists varied in the frequency of perfect performance from 0% for meeting every item on the checklist for disinfection practices to 22% on the arteriovenous access practices at initiation. CONCLUSIONS Our findings suggest that there are many areas for improvement in hand hygiene and other infection prevention practices in end-stage renal disease. These NOTICE project findings will help inform the development of a larger quality improvement initiative at dialysis facilities.

  9. ESRD - Clinical Performance Measures (CPM) Project

    Data.gov (United States)

    U.S. Department of Health & Human Services — Section 4558 (b) of the Balanced Budget Act (BBA) requires CMS to develop and implement by January 1, 2000, a method to measure and report the quality of renal...

  10. [The incidence of ESRD in 2011].

    Science.gov (United States)

    Briançon, S; Lange, C; Thibon, P; Jacquelinet, C; Stengel, B

    2013-09-01

    This chapter provides a set of indicators on incident patients with renal replacement therapy. In 2011, in 25 French regions (99% population), 9 248 patients started a treatment by dialysis (incidence of dialysis: 149 per million inhabitants) and 334 patients with a pre-emptive graft without previous dialysis (incidence of pre-emptive graft: 5 per million inhabitants). One patient among two are over 70 years old at renal replacement therapy initiation. As in 2010, incidence rate seems to stabilize. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  11. [Survival and mortality in ESRD patients].

    Science.gov (United States)

    Chantrel, F; de Cornelissen, F; Deloumeaux, J; Lange, C; Lassalle, M

    2013-09-01

    This chapter provides a set of indicators on survival, life expectancy and causes of death of patients in chronic renal failure treated by dialysis or transplantation beginning a first replacement therapy between 2002 and 2011. Age strongly influences survival on dialysis. Thus, one year survival of patients under age 65 is over 90%. After 5 years, among patients over 85 years, it is more than 15%. The presence of diabetes or one or more cardiovascular comorbidities also significantly worse patient survival. In terms of trend, we do not find significant improvement in the 2-year survival between patients in the cohort 2006-2007 and the 2008-2009 cohort. Cardiovascular diseases account for 27% of causes of death to infectious diseases (12%) and cancer (10%). Life expectancy of patients is highly dependent on their treatment. Thus, a transplant patient aged 30 has a life expectancy of 41 years versus 23 years for a dialysis patient. Transplant patients have a mortality rate much lower than those of dialysis patients. Thus, between 60 and 69 years, for 1000 patients in dialysis in 2011, 127 died within the year. For 1000 patients of the same age, who have a functioning kidney transplant, 24 died within the year. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  12. ESRD - Clinical Performance Measures (CPM) Project

    Data.gov (United States)

    U.S. Department of Health & Human Services — Section 4558 (b) of the Balanced Budget Act (BBA) requires CMS to develop and implement by January 1, 2000, a method to measure and report the quality of renal...

  13. ESRD Quality Incentive Program Public Reporting

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare Improvements for Patients and Providers Act (MIPPA) of 2008 requires that CMS and facilities inform beneficiaries about facility performance under the...

  14. 血液透析对新诊断终末期肾脏疾病患者血清氨基酸的影响%Effects of hemodialysis therapy on serum amino acids in newly diagnosed ESRD patients

    Institute of Scientific and Technical Information of China (English)

    王萍; 蒋更如

    2008-01-01

    目的 探讨血液透析(HD)对新诊断的终末期肾脏疾病(ESRD)患者血清氨基酸水平的影响.方法 对30例新诊断且需要HD治疗的ESRD患者采用高压液相色谱法分别测定HD治疗前和治疗后3、6个月的血清氨基酸水平,并进行统计学分析.结果 与HD治疗前比较,患者治疗后3个月和6个月的血清组氨酸(His)、苏氨酸(Thr)、脯氨酸(Pro)、酪氮酸(Tyr)、缬氨酸(Val)、蛋氨酸(Met)、异亮氨酸(Ile)、亮氨酸(Leu)及苯丙氨酸(Phe)水平均明显增加(P<0.05);与治疗前和治疗后3个月比较,治疗后6个月患者的血清谷氨酸(Glu)和半胱氨酸(cyB)水平明显升高(P<0.05);HD治疗后3个月,患者血清天冬氨酸(Asp)、丝氨酸(Ser)、甘氨酸(Gly)、丙氨酸(Ala)、精氨酸(Arg)和赖氨酸(Lys)水平较治疗前明显增加(P<0.05);而至治疗后6个月时又呈现下降趋势,其中Asp、Ser、Gly、Ala水平与治疗后3个月比较差异有统计学意义(P<0.05).结论 及时进行HD治疗可提高新诊断ESRD患者血清氨基酸水平,改善营养状况.

  15. Força muscular respiratória e capacidade funcional na insuficiência renal terminal Respiratory muscle strength and functional capacity in end-stage renal disease (ESRD

    Directory of Open Access Journals (Sweden)

    Thiago Dipp

    2010-08-01

    Full Text Available OBJETIVO: Verificar a associação da força muscular respiratória com a capacidade funcional, força proximal de membros inferiores e variáveis bioquímicas em pacientes em hemodiálise (HD. MÉTODOS: Participaram deste estudo 30 indivíduos (18 homens, com 53,4 ± 12,9 anos e tempo de HD de 41,1 ± 55,7 meses. Foram avaliados pressão inspiratória máxima (PImax, pressão expiratória máxima (PEmax, distância percorrida no teste de caminhada de seis minutos (6MWT, número de repetições no teste de sentar-e-levantar em 30 segundos (TSL e registrados os exames bioquímicos de rotina no serviço. RESULTADOS: Houve diminuição da PEmax em relação aos valores preditos (p = 0,015 e redução na distância percorrida no 6MWT quando comparados com equações de predição (p OBJECTIVE: to evaluate the association of respiratory muscle strength with functional capacity, lower limb strength and biochemical variables in hemodialysis (HD patients. METHODS: a cross-sectional study involving 30 patients (18 male, 53.4 ± 12.9 years, 41.1 ± 55.7 months on HD therapy. Maximal inspiratory pressure (PImax, maximal expiratory pressure (PEmax, distance completed in a six-minute walk test (6MWT and number of repetitions in sit-and-stand test (STST were evaluated. The biochemical variables were recorded in the database routine work service. RESULTS: LogEPmax and 6MWT values were significantly lower than the predicted values (p = 0.015; p < 0.001, respectively. logPImax and logPEmax were correlated with number of repetitions in STST (r = 0.476, p = 0.008; r = 0.540, p = 0.002, respectively and with phosphorus blood levels (r = 0.422, p = 0.020; r = 0.639, p < 0.001, respectively. 6MWT was correlated with logPEmax (r = 0.511; p = 0.004 and with number of repetitions in STST (r = 0.561; p = 0.001. CONCLUSION: PEmax reduction in patients with ESRD on HD is associated with functional capacity, lower limb strength and phosphorus blood levels, and may at least

  16. Effect of Daytime Ambulatory Peritoneal Dialysis on Volume Load in ESRD Patients%日间非卧床腹膜透析对ESRD患者容量负荷的影响

    Institute of Scientific and Technical Information of China (English)

    王鑫; 高弼虎; 钟麟; 朴眀姬; 张亚男

    2014-01-01

    目的:探讨日间非卧床腹膜透析(DAPD)及持续非卧床腹膜透析(CAPD)对ESRD患者容量负荷的影响。方法选我院肾内科行腹膜透析患者36例,随机分成DAPD组(A组)与CAPD组(B组)2组,A组16例,采用DAPD模式,即日间采用8L的透析剂量,4次交换,每4~5h交换一次透析液,夜间干腹;B组20例,采用CAPD模式,每天的透析剂量为8L,4次交换,每4~5h交换一次透析液,夜间留腹。随访2年,记录2组患者体质量及体质量指数(BMI)、血压、心胸比、左心室后壁厚度、室间隔厚度、血红蛋白、血清白蛋白等指标,比较2组患者透析充分性,包括尿素清除指数[Kt/V(周)]、肌酐清除率(Ccr),实验数据以(χ-±s)表示,两组定量资料间的比较采用t检验,P<0.05表示差异有统计学意义。结果A、B两组患者在残余尿量、透析充分性[Kt/V(周)、Ccr]、血红蛋白、血清白蛋白等方面比较差异无统计学意义(P>0.05);A组在血压、体质量增加量、超滤量、心胸比、左心室后壁厚度、室间隔厚度等方面均优于B组,差异有统计学意义(P<0.05)。结论在使用相同透析剂量的情况下,行DAPD治疗的患者比CAPD患者在容量负荷方面有更满意的临床疗效。%Objective To explore the effect of both daytime ambulatory peritoneal dialysis (DAPD) and continuous ambulatory peritoneal dialysis (CAPD) on volume load in ESRD patients. Methods A total of 36 patients subjected to peritoneal dialysis in our hospital were selected and randomized into group A (n=16) and group B (n=20). Patients in group A were treated with DAPD by using 8 L dialysate at daytime, dialysate exchange every 4-5 hours, and evacuation of dialysate from abdomen at night. Patients in group B were treated with CAPD by using the dialysate 8 L/day, four exchanges per day, dialysate exchange every 4-5 hours, and dialysate left in abdomen

  17. [Just-in-time initiation of optimal dialysis].

    Science.gov (United States)

    Cornelis, Tom; Kooman, Jeroen P; van der Sande, Frank M

    2010-01-01

    The IDEAL trial shows that the decision to start renal replacement treatment should not depend on GFR alone, but should be taken on the basis of clinical parameters. Quality of Life (QoL) questionnaires and bio-impedance analysis are potential tools for detecting subtle changes in the predialysis clinic. Too early an initiation of dialysis may be deleterious for the patient and the healthcare system. We are convinced that ESRD patients should be informed about intensive haemodialysis (HD), especially nocturnal (home) HD, as the best available dialysis modality. There is substantial evidence which shows that intensive HD improves clinical, biochemical and biological parameters, and may even prolong survival. We believe that 'just-in-time delivery of intensive haemodialysis' may result in optimised QoL and reduced economic burden.

  18. Time-updated systolic blood pressure and the progression of chronic kidney disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

    Science.gov (United States)

    Anderson, Amanda H; Yang, Wei; Townsend, Raymond R; Pan, Qiang; Chertow, Glenn M; Kusek, John W; Charleston, Jeanne; He, Jiang; Kallem, RadhaKrishna; Lash, James P; Miller, Edgar R; Rahman, Mahboob; Steigerwalt, Susan; Weir, Matthew; Wright, Jackson T; Feldman, Harold I

    2015-01-01

    Background Blood pressure (BP) is often inadequately controlled in patients with chronic kidney disease (CKD). Previous reports of the longitudinal association between achieved level of BP and end-stage renal disease (ESRD) have not incorporated time-updated BP with appropriate adjustment for known confounders. Objective To assess the association between baseline and time-updated systolic BP (SBP) with the progression of CKD. Design Observational, prospective cohort study (ClinicalTrials.gov identifier: NCT00304148) Setting Seven US clinical centers Patients Participants of the Chronic Renal Insufficiency Cohort (CRIC) Study (N=3,708) followed for a median (25th, 75th percentiles) of 5.7 (4.6, 6.7) years Measurements The mean of three seated SBP measurements were used as the visit-specific SBP. SBP was time-updated as the mean of that visit and all prior visits. Outcomes were ESRD and the composite renal endpoint of ESRD (dialysis or transplantation) or halving of the estimated glomerular filtration rate (eGFR). Analyses investigating baseline and time-updated SBP utilized traditional Cox proportional hazards models and marginal structural models, respectively. Results SBP was ≥130 mmHg at all study visits in 19.2% of participants, and ≥140 mmHg in 10.6%. The hazard ratio (95% confidence interval) for ESRD among participants with SBP 130–139 mmHg, compared to SBP <120 mmHg, was 1.46 (1.13–1.88) using only baseline data, and was 2.37 (1.48–3.80) using all available time-updated data. Among those with SBP ≥140 mmHg, corresponding hazard ratios were 1.46 (1.18–1.88) and 3.37 (2.26–5.03), respectively. Limitations SBP was measured once annually, and the CRIC Study cohort is not a random sample. Conclusions Among participants in the CRIC Study, time-updated SBP over 130 mmHg was more strongly associated with progression of CKD than analyses based on baseline SBP. Funding The CRIC Study is funded under cooperative agreements from the National Institute of

  19. 终末期肾脏病患者血清ucMGP及PIVKA-Ⅱ与桡动脉钙化的相关性%Correlation between serum concentrations of ucMGP and PIVKA-Ⅱ and calcification of radial artery in patients with ESRD

    Institute of Scientific and Technical Information of China (English)

    王科; 任伟; 汪鹏; 王珣; 倪力军

    2014-01-01

    目的 探讨血清非活性基质Gla蛋白(ucMGP)及凝血酶原前体蛋白(PIVKA-Ⅱ)与终末期肾脏病(ESRD)患者桡动脉钙化的关系.方法 选取45例ESRD住院患者作为病例组,行动静脉内瘘手术时取桡动脉标本,桡动脉标本均行von kossa染色,判断有无钙化,并计算钙化积分.选取同期健康体检人群30例作为对照组.所有研究对象均检测血清ucMGP、PIVKA-Ⅱ、血红蛋白(Hb)、钙(Ca)、磷(P)、白蛋白(ALB)、全段甲状旁腺素(iPTH)、C反应蛋白(CRP)指标.结果 病例组血清ucMGP低于对照组(P<0.01),PIVKA-Ⅱ高于对照组(P<0.01).在病例组中桡动脉钙化与高血P相关,与低ucMGP相关.血清PIVKA-Ⅱ与ucMGP水平及桡动脉钙化无相关性.结论 ESRD患者血清ucMGP低于正常人群,且与桡动脉钙化相关.ESRD患者血清PIVKA-Ⅱ高于正常人群.

  20. Old times Old times

    Directory of Open Access Journals (Sweden)

    Ubiratan Paiva de Oliveira

    2008-04-01

    Full Text Available In Pinter: A Study of His Plays, Martin Esslin mentions three levels of possible interpretation for Old Times. According to him, Pinter's play could be interpreted on a realistic level, or either representing the male character's dream or a ritual game. He correctly remarks, though, that none of those levels excludes the others, because "... they must co-exist to create the atmosphere of poetic ambivalence on which the image of the play rests..1 In Pinter: A Study of His Plays, Martin Esslin mentions three levels of possible interpretation for Old Times. According to him, Pinter's play could be interpreted on a realistic level, or either representing the male character's dream or a ritual game. He correctly remarks, though, that none of those levels excludes the others, because "... they must co-exist to create the atmosphere of poetic ambivalence on which the image of the play rests..1

  1. Sexual dysfunction in women with ESRD requiring hemodialysis

    NARCIS (Netherlands)

    Strippoli, G.F.; Vecchio, M.; Palmer, S.; Berardis, G. de; Craig, J.; Lucisano, G.; Johnson, D.; Pellegrini, F.; Nicolucci, A.; Sciancalepore, M.; Saglimbene, V.; Gargano, L.; Bonifati, C.; Ruospo, M.; Navaneethan, S.D.; Montinaro, V.; Stroumza, P.; Zsom, M.; Torok, M.; Celia, E.; Gelfman, R.; Bednarek-Skublewska, A.; Dulawa, J.; Graziano, G.; Gentile, G.; Ferrari, J.N.; Santoro, A.; Zucchelli, A.; Triolo, G.; Maffei, S.; Hegbrant, J.; Wollheim, C.; Cosmo, S. de; Manfreda, V.M.; Steiner, K.

    2012-01-01

    BACKGROUND AND OBJECTIVES: The few existing studies of sexual dysfunction in women on hemodialysis are limited by small sample size. This large, cross-sectional study evaluated the prevalence and correlates of female sexual dysfunction in advanced kidney disease. DESIGN, SETTING, PARTICIPANTS, METHO

  2. Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.

    Science.gov (United States)

    Roberts, John K; Westphal, Scott; Sparks, Matthew A

    2015-01-01

    Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily dependent on intact renal function, and the contraindication for use in patients with insufficient renal function is not well recognized by healthcare providers. Here, the authors report a series of mild to severe cases of baclofen intoxication in patients with end-stage renal disease. In all cases, baclofen was initiated by either inpatient or outpatient healthcare providers and the patients generally presented with altered mentation, somnolence, and/or respiratory depression. All patients were treated with aggressive hemodialysis and made a full recovery. This paper will briefly review the literature regarding baclofen intoxication, safety of baclofen use in renal disease, and efficacy of extracorporeal therapy in the treatment of baclofen intoxication.

  3. Exercise training and depression in ESRD: a review.

    Science.gov (United States)

    Mitrou, Georgia I; Grigoriou, Stefania S; Konstantopoulou, Evi; Theofilou, Paraskevi; Giannaki, Christoforos D; Stefanidis, Ioannis; Karatzaferi, Christina; Sakkas, Giorgos K

    2013-01-01

    Depression, a mental disorder with a high personal, societal, and economic impact, affects at least 20-30% of patients receiving hemodialysis therapy. It is associated with a high mortality rate, low adherence to medication, and a low perceived quality of life. Exercise training is a promising nonpharmacological intervention that can be safely applied to these patients. Beyond the well-publicized physiological benefits of exercise training, a number of studies have focused on the effects of exercise training on mental factors and quality of life parameters including its less appreciated effects on depression symptoms. This evidence-based review article reviews and discusses the effects of exercise training on depression in end-stage renal disease patients.

  4. Sexual dysfunction in women with ESRD requiring hemodialysis

    NARCIS (Netherlands)

    Strippoli, G.F.; Vecchio, M.; Palmer, S.; Berardis, G. de; Craig, J.; Lucisano, G.; Johnson, D.; Pellegrini, F.; Nicolucci, A.; Sciancalepore, M.; Saglimbene, V.; Gargano, L.; Bonifati, C.; Ruospo, M.; Navaneethan, S.D.; Montinaro, V.; Stroumza, P.; Zsom, M.; Torok, M.; Celia, E.; Gelfman, R.; Bednarek-Skublewska, A.; Dulawa, J.; Graziano, G.; Gentile, G.; Ferrari, J.N.; Santoro, A.; Zucchelli, A.; Triolo, G.; Maffei, S.; Hegbrant, J.; Wollheim, C.; Cosmo, S. de; Manfreda, V.M.; Steiner, K.

    2012-01-01

    BACKGROUND AND OBJECTIVES: The few existing studies of sexual dysfunction in women on hemodialysis are limited by small sample size. This large, cross-sectional study evaluated the prevalence and correlates of female sexual dysfunction in advanced kidney disease. DESIGN, SETTING, PARTICIPANTS,

  5. [Flows between modalities in the treatment of ESRD].

    Science.gov (United States)

    Labeeuw, M; Couchoud, C

    2013-09-01

    This chapter provides indicators to describe the outcome of prevalent and incident patients in the various modalities of treatment. Among the 36 849 patients on dialysis at 31/10/2010, 79% were already on RRT at 31/12/2009. Respectively 91%, 85% and 93% of the patients on HD in-center, HD self-care unit and peritoneal dialysis were in the same modality of treatment the year before. Among the 29 758 patients with a functioning graft at 31/12/2010, 98% were already on RRT at 31/12/2009, 95% of them with a functioning graft. 72%, 72% and 74% of the patients with in-center HD, outcenter HD and self-care unit were in the same modality of treatment at 31/12/2011. But 37% of the patients on PD at 31/12/2010 were not on PD at 31/12/2011. In 2011, new patients represented 89% of the entries in peritoneal dialysis. Renal transplantation represented 10% of the outcomes of the HD patients in self-care unit or at home. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  6. New Insights into Dialysis Vascular Access: What Is the Optimal Vascular Access Type and Timing of Access Creation in CKD and Dialysis Patients?

    Science.gov (United States)

    Woo, Karen; Lok, Charmaine E

    2016-08-08

    Optimal vascular access planning begins when the patient is in the predialysis stages of CKD. The choice of optimal vascular access for an individual patient and determining timing of access creation are dependent on a multitude of factors that can vary widely with each patient, including demographics, comorbidities, anatomy, and personal preferences. It is important to consider every patient's ESRD life plan (hence, their overall dialysis access life plan for every vascular access creation or placement). Optimal access type and timing of access creation are also influenced by factors external to the patient, such as surgeon experience and processes of care. In this review, we will discuss the key determinants in optimal access type and timing of access creation for upper extremity arteriovenous fistulas and grafts.

  7. Longitudinal Serum Creatinine Levels in Relation to Graft Loss Following Renal Transplantation: Robust Joint Modeling of Longitudinal Measurements and Survival Time Data

    Directory of Open Access Journals (Sweden)

    Younespour

    2016-08-01

    Full Text Available Background Chronic kidney disease (CKD is a major public health problem that may lead to end-stage renal disease (ESRD. Renal transplantation has become the treatment modality of choice for the majority of patients with ESRD. It is therefore necessary to monitor the disease progression of patients who have undergone renal transplantation. In order to monitor the disease progression, the continuous assessment of kidney function over time is considered. Objectives This study aimed to investigate the etiological role of recipient characteristics in serum creatinine changes within the follow-up period and in relation to the graft failure risk, as well as to evaluate whether or not the serum creatinine level represents an indicator of graft failure following renal transplantation. Methods This retrospective cohort study was conducted at the department of nephrology, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, between April 2005 and December 2008. The study involved 413 renal transplantation patients. The primary outcomes were the determination of the serum creatinine levels at each attendance and the time to graft failure. Robust joint modeling of the longitudinal measurements (serum creatinine level and time-to-event data (time to graft failure were used for the analysis in the presence of outliers in the serum creatinine levels. The data analysis was implemented in WinBUGS 1.4.3. Results There was a positive association between the serum creatinine level and graft failure (HR = 5.13, P < 0.001. A one unit increase in the serum creatinine level suggests an increased risk of graft failure of up to 5.13 times. The serum creatinine level significantly decreased over time (95% CI: (-1.58, -1.08. The recipient’s age was negatively associated with the serum creatinine level (95% CI: (-0.02, -0.001. Conclusions Graft failure is more likely to occur in patients with higher serum creatinine levels.

  8. Solar time, legal time, time in use

    Science.gov (United States)

    Guinot, Bernard

    2011-08-01

    The International Conference held in 1884 at Washington defined a universal time as the mean solar time at the Greenwich meridian (GMT). Now, the Universal Time, version UT1, is strictly defined as proportional to the angle of rotation of the Earth in space. In this evolution, the departure of UT1 from GMT does not exceed one or two seconds. This is quite negligible when compared with the departure between the solar time and the legal time of citizens, which may exceed two hours without raising protests.

  9. Time outs

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000756.htm Time outs To use the sharing features on this ... children, 2 to 12 years old. Why Does Time out Work? When you put children in time ...

  10. Arterial Stiffness and Walk Time in Patients with End-Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Abbi D. Lane

    2013-04-01

    Full Text Available Background: End-stage renal disease patients experience increased prevalence of cardiovascular disease. Heart-artery interaction may be shifted, impacting blood pressure lability, and exercise tolerance. The coupling ratio consists of the ratio of indexed arterial elastance (EaI, arterial load to ElvI, a measure of cardiac contractility or stiffness. Our purpose was to explore the relationship between elastances and functional capacity. We hypothesized that arterial stiffness (central pulse wave velocity, PWV and elastances would be correlated to shuttle walk time. Methods: We used applanation tonometry, ultrasonography, and a shuttle walk test to evaluate our hypothesis. Spearman's correlations were used to assess relationships between variables. Block regression was also performed. Results: Forty-two subjects on maintenance hemodialysis participated. Average age=44±5 years, body surface area=2.01 kg/m2. Mean EaI=4.45 and mean ElvI=6.89; the coupling ratio=0.82. Mean aortic pulse pressure=51 mmHg and PWV=9.6 m/s. PWV(r=-0.385 and EaI (r=-0.424 were significantly and inversely related to walking time while stroke volume index (SVI was positively correlated to shuttle walk time (r=0.337, pConclusions: We conclude that, like other clinical populations, both arterial and heart function predict walking ability and represent potential targets for intervention; arterial stiffness and SVI are strongly related to shuttle walk time in patients with ESRD.

  11. Time change

    DEFF Research Database (Denmark)

    Veraart, Almut; Winkel, Matthias

    2010-01-01

    The mathematical operation of time-changing continuous-time stochastic processes can be regarded as a standard method for building financial models. We briefly review the theory on time-changed stochastic processes and relate them to stochastic volatility models in finance. Popular models......, including time-changed Lévy processes, where the time-change process is given by a subordinator or an absolutely continuous time change, are presented. Finally, we discuss the potential and the limitations of using such processes for constructing multivariate financial models....

  12. Time change

    DEFF Research Database (Denmark)

    Veraart, Almut; Winkel, Matthias

    2010-01-01

    The mathematical operation of time-changing continuous-time stochastic processes can be regarded as a standard method for building financial models. We briefly review the theory on time-changed stochastic processes and relate them to stochastic volatility models in finance. Popular models......, including time-changed Lévy processes, where the time-change process is given by a subordinator or an absolutely continuous time change, are presented. Finally, we discuss the potential and the limitations of using such processes for constructing multivariate financial models....

  13. Urban Times

    DEFF Research Database (Denmark)

    Nielsen, Morten

    2016-01-01

    This is a proposed special issue with six thematic articles by different contributors on 'urban times' edited by me.......This is a proposed special issue with six thematic articles by different contributors on 'urban times' edited by me....

  14. Urban Times

    DEFF Research Database (Denmark)

    Nielsen, Morten

    2016-01-01

    This is a proposed special issue with six thematic articles by different contributors on 'urban times' edited by me.......This is a proposed special issue with six thematic articles by different contributors on 'urban times' edited by me....

  15. Different Times?

    NARCIS (Netherlands)

    A. van den Broek; W.P. Knulst; K. Breedveld

    1999-01-01

    Original title: Naar andere tijden? The report Different times? Time use and time structuring in the Netherlands, 1975-1995 (Naar andere tijden? Tijdsbesteding en tijdsordening in Nederland, 1975-1995) paints a picture of the way in which the Dutch spend the 168 hours that are available each

  16. Different Times?

    NARCIS (Netherlands)

    A. van den Broek; W.P. Knulst; K. Breedveld

    1999-01-01

    Original title: Naar andere tijden? The report Different times? Time use and time structuring in the Netherlands, 1975-1995 (Naar andere tijden? Tijdsbesteding en tijdsordening in Nederland, 1975-1995) paints a picture of the way in which the Dutch spend the 168 hours that are available each week.

  17. Different Times?

    NARCIS (Netherlands)

    A. van den Broek; W.P. Knulst; K. Breedveld

    1999-01-01

    Original title: Naar andere tijden? The report Different times? Time use and time structuring in the Netherlands, 1975-1995 (Naar andere tijden? Tijdsbesteding en tijdsordening in Nederland, 1975-1995) paints a picture of the way in which the Dutch spend the 168 hours that are available each week.

  18. Quantum Time

    CERN Document Server

    Ashmead, John

    2010-01-01

    Normally we quantize along the space dimensions but treat time classically. But from relativity we expect a high level of symmetry between time and space. What happens if we quantize time using the same rules we use to quantize space? To do this, we generalize the paths in the Feynman path integral to include paths that vary in time as well as in space. We use Morlet wavelet decomposition to ensure convergence and normalization of the path integrals. We derive the Schr\\"odinger equation in four dimensions from the short time limit of the path integral expression. We verify that we recover standard quantum theory in the non-relativistic, semi-classical, and long time limits. Quantum time is an experiment factory: most foundational experiments in quantum mechanics can be modified in a way that makes them tests of quantum time. We look at single and double slits in time, scattering by time-varying electric and magnetic fields, and the Aharonov-Bohm effect in time.

  19. Albuminuria : Is it Time to Screen the General Population?

    NARCIS (Netherlands)

    Crews, Deidra C.; Boulware, L. Ebony; Gansevoort, Ron T.; Jaar, Bernard G.

    2011-01-01

    Albuminuria has been associated with increased risk of multiple adverse outcomes, including ESRD, acute kidney injury, cardiovascular disease, and death. Some clinicians advocate for population-based screening of this condition, as a means of identifying individuals at high risk for morbidity and mo

  20. Effect of hemodiafiltration on quality of life over time

    NARCIS (Netherlands)

    Mazairac, A.H.; Wit, G.A. de; Grooteman, M.P.C.; Penne, E.L.; Weerd, N.C. van der; Hoedt, C.H. den; Levesque, R.; Dorpel, M.A. van den; Nube, M.J.; Wee, P.M. ter; Bots, M.L.; Blankestijn, P.J.; Hamersvelt, H.W. van

    2013-01-01

    BACKGROUND AND OBJECTIVES: It is unclear if hemodiafiltration leads to a better quality of life compared with hemodialysis. It was, therefore, the aim of this study to assess the effect of hemodiafiltration on quality of life compared with hemodialysis in patients with ESRD. DESIGN, SETTING, PARTICI

  1. Effect of hemodiafiltration on quality of life over time

    NARCIS (Netherlands)

    A.H.A. Mazairac (Albert); G.A. de Wit (Ardine); M.P.C. Grooteman (Muriel); E.L. Penne (Lars); N.C. van der Weerd (Neelke); C.H. den Hoedt (Claire); R. Lévesque (Renée); M.A. van den Dorpel (Marinus); M.J. Nubé (Menso); P.M. ter Wee (Piet); M.L. Bots (Michiel); P.J. Blankestijn (Peter)

    2013-01-01

    textabstractBackground and objectives It is unclear if hemodiafiltration leads to a better quality of life compared with hemodialysis. It was, therefore, the aim of this study to assess the effect of hemodiafiltration on quality of life compared with hemodialysis in patients with ESRD. Design, setti

  2. Time Series

    OpenAIRE

    Gil-Alana, L.A.; Moreno, A; Pérez-de-Gracia, F. (Fernando)

    2011-01-01

    The last 20 years have witnessed a considerable increase in the use of time series techniques in econometrics. The articles in this important set have been chosen to illustrate the main themes in time series work as it relates to econometrics. The editor has written a new concise introduction to accompany the articles. Sections covered include: Ad Hoc Forecasting Procedures, ARIMA Modelling, Structural Time Series Models, Unit Roots, Detrending and Non-stationarity, Seasonality, Seasonal Adju...

  3. Spatializing Time

    DEFF Research Database (Denmark)

    Thomsen, Bodil Marie Stavning

    2011-01-01

    The article analyses some of artist Søren Lose's photographic installations in which time, history and narration is reflected in the creation of allegoric, spatial relations.......The article analyses some of artist Søren Lose's photographic installations in which time, history and narration is reflected in the creation of allegoric, spatial relations....

  4. Time Management

    Science.gov (United States)

    Stoilov, Todor, Ed.

    2012-01-01

    The time management is worthy goal of many human activities. It concerns variety problems related to goals definition, assessment of available resources, control of management policies, scheduling of decisions. This book is an attempt to illustrate the decision making process in time management for different success stories, which can be used as…

  5. Spatializing Time

    DEFF Research Database (Denmark)

    2011-01-01

    The article analyses some of artist Søren Lose's photographic installations in which time, history and narration is reflected in the creation of allegoric, spatial relations.......The article analyses some of artist Søren Lose's photographic installations in which time, history and narration is reflected in the creation of allegoric, spatial relations....

  6. Time Management

    Science.gov (United States)

    Stoilov, Todor, Ed.

    2012-01-01

    The time management is worthy goal of many human activities. It concerns variety problems related to goals definition, assessment of available resources, control of management policies, scheduling of decisions. This book is an attempt to illustrate the decision making process in time management for different success stories, which can be used as…

  7. About time

    CERN Document Server

    Frank, Adam

    2012-01-01

    From Stonehenge to beyond the Big Bang, an exhilarating scientific exploration of how we make time Time is the grandest conception of the universe that we humans have been able to imagine – and its most intimate, the very frame of human life. In About Time, astrophysicist and award-winning writer Adam Frank tells the scientific story of this wonderful and tyrannical invention. A Palaeolithic farmer moved through the sun-fuelled day and star-steered night in a radically different way than the Elizabethan merchants who set their pace to the clocks newly installed in their town squares. Since th

  8. Timing of dialysis initiation in the geriatric population: toward a patient-centered approach.

    Science.gov (United States)

    Treit, Kathryn; Lam, Daniel; O'Hare, Ann M

    2013-01-01

    Over the last 10-15 years, the incidence of treated end-stage renal disease (ESRD) among older adults has increased and dialysis is being initiated at progressively higher levels of estimated glomerular filtration rate (eGFR). Average life expectancy after dialysis initiation among older adults is quite limited, and many experience an escalation of care and loss of independence after starting dialysis. Available data suggest that treatment decisions about dialysis initiation in older adults in the United States are guided more by system- than by patient-level factors. Stronger efforts are thus needed to ensure that treatment decisions for older adults with advanced kidney disease are optimally aligned with their goals and preferences. There is growing interest in more conservative approaches to the management of advanced kidney disease in older patients who prefer not to initiate dialysis and those for whom the harms of dialysis are expected to outweigh the benefits. A number of small single center studies, mostly from the United Kingdom report similar survival among the subset of older adults with a high burden of comorbidity treated with dialysis vs. those managed conservatively. However, the incidence of treated ESRD in older US adults is several-fold higher than in the United Kingdom, despite a similar prevalence of chronic kidney disease, suggesting large differences in the social, cultural, and economic context in which dialysis treatment decisions unfold. Thus, efforts may be needed to adapt conservative care models developed outside the United States to optimally meet the needs of US patients. More flexible approaches toward dialysis prescription and better integration of treatment decisions about conservative care with those related to modality selection will likely be helpful in meeting the needs of individual patients. Regardless of the chosen treatment strategy, time can often be a critical ally in centering care on what matters most to the patient, and

  9. Time-out/Time-in

    DEFF Research Database (Denmark)

    Bødker, Mads; Gimpel, Gregory; Hedman, Jonas

    2014-01-01

    time-in and time-out use. Time-in technology use coincides and co-exists within the flow of ordinary life, while time-out use entails ‘taking time out’ of everyday life to accomplish a circumscribed task or engage reflectively in a particular experience. We apply a theoretically informed grounded...... approach to data collected through a longitudinal field study of smartphone users during a 6-month period. We analysed the data based on the concept of time-in/out and show the dynamics in the experience of a device that changes from the ‘extraordinary’ to the ‘ordinary’ over time. We also provide...... a vocabulary that describes this relationship as stages resembling the one between a couple, which evolves from an early love affair, to being married and to growing old together. By repurposing the time-in/out distinction from its origin in media studies, this paper marks a move that allows the distinction...

  10. Time Discounting and Time Consistency

    NARCIS (Netherlands)

    N. Dimitri; D.J.N. van Eijck (Jan)

    2011-01-01

    htmlabstractTime discounting is the phenomenon that a desired result in the future is perceived as less valuable than the same result now. Economic theories can take this psychological fact into account in several ways. In the economic literature the most widely used type of additive time discountin

  11. Time discounting and time consistency

    NARCIS (Netherlands)

    Dimitri, N.; Eijck, D.J.N. van

    2012-01-01

    Time discounting is the phenomenon that a desired result in the future is perceived as less valuable than the same result now. Economic theories can take this psychological fact into account in several ways. In the economic literature the most widely used type of additive time discounting is

  12. Changing times

    DEFF Research Database (Denmark)

    Liversage, Anika; Ottosen, Mai Heide

    2014-01-01

    family. In contrast, Turkish immigrant women's family formation processes consist of tightly clustered transitions, occurring in a normatively sanctioned order. While the timing of these transitions in the 1990s clearly resembled the processes found in Turkish villages, this timing has since changed....... Greater participation in education in Denmark contributes both to young Turkish women increasingly postponing marriage and the partner selection processes changing considerably. While Turkish immigrant women are now getting married at older ages, some do so without changing the sequencing of other family...

  13. Present time

    CERN Document Server

    Romero, Gustavo E

    2014-01-01

    The idea of a moving present or `now' seems to form part of our most basic beliefs about reality. Such a present, however, is not reflected in any of our theories of the physical world. I show in this article that presentism, the doctrine that only what is present exists, is in conflict with modern relativistic cosmology and recent advances in neurosciences. I argue for a tenseless view of time, where what we call `the present' is just an emergent secondary quality arising from the interaction of perceiving self-conscious individuals with their environment. I maintain that there is no flow of time, but just an ordered system of events.

  14. Reckoning Time

    Institute of Scientific and Technical Information of China (English)

    HUHONGQI

    2005-01-01

    The beginning of a new year is traditionany reckoning time. Analysts, economists, politicians and pundits are looking back so as to make an educated guess for the imminent and distant future. The final data for 2004 are not yet ha the books, but it is already easy to conclude that the past year was economically speaking a very successful one indeed.

  15. Time matters

    DEFF Research Database (Denmark)

    Andreasen, Karen Egedal; Rasmussen, Annette

    such as the PISA studies, and tendencies in educational politics and schoolsystems in Europe, USA, Australia and Asia. This spring (2011) all danish pupils in grade 6. has been tested nationally for the first time in reading skills and mathematics. The argumentation behind the initiative points to both economical...

  16. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  17. Timing earnings

    Institute of Scientific and Technical Information of China (English)

    Donghua; Chen; Xiangqin; Qi; Yongjian; Shen; Huimiao; Lin

    2011-01-01

    Since the opening of China’s securities market,there have been a number of bull and bear cycles.This paper discusses how executives use the market timing approach to manage earnings in different cycles to maximize firm value.We find that Chinese listed companies choose to release more earnings during bull markets and this phenomenon is more evident in companies that are more profitable and have higher valuations.We also find that executives who do not release more earnings during bull markets are more likely to be dismissed.

  18. Timing matters

    DEFF Research Database (Denmark)

    Kothari, Ninad B.; Wohlgemuth, Melville J.; Hulgard, Katrine;

    2014-01-01

    To successfully negotiate a cluttered environment, an echolocating bat must control the timing of motor behaviors in response to dynamic sensory information. Here we detail the big brown bat's adaptive temporal control over sonar call production for tracking prey, moving predictably or unpredicta......To successfully negotiate a cluttered environment, an echolocating bat must control the timing of motor behaviors in response to dynamic sensory information. Here we detail the big brown bat's adaptive temporal control over sonar call production for tracking prey, moving predictably...... or unpredictably, under different experimental conditions. We studied the adaptive control of vocal-motor behaviors in free-flying big brown bats, Eptesicus fuscus, as they captured tethered and free-flying insects, in open and cluttered environments. We also studied adaptive sonar behavior in bats trained...... to track moving targets from a resting position. In each of these experiments, bats adjusted the features of their calls to separate target and clutter. Under many task conditions, flying bats produced prominent sonar sound groups identified as clusters of echolocation pulses with relatively stable...

  19. Yet another time about time

    CERN Document Server

    Simeonov, Plamen L

    2015-01-01

    This paper presents yet another personal reflection on one the most important concepts in both science and the humanities: time. This elusive notion has been not only bothering philosophers since Plato and Aristotle and goes throughout human history embracing all analytical and creative (anthropocentric) disciplines from mathematics through physical and life sciences to philosophy, psychology, music and art, with a vast body of knowledge across different theories and categories concerning its nature (rational, irrational, arational), appearances/qualia, degrees, dimensions and scales of conceptualization (internal, external, rational, irrational, fractal, discrete, continuous, mechanical, quantum, local, global, etc.), duration ranges, resolutions, modes (present, now, past, future), variety of tenses (e.g. present perfect, present progressive, etc.) and some intuitive, but also fancy phenomenological characteristics such as arrow, stream, texture, width, depth, and perhaps the most distinct one of them, the ...

  20. Syndrome of rapid onset end stage renal disease in incident Mayo Clinic chronic hemodialysis patient

    Directory of Open Access Journals (Sweden)

    M. A. C. Onuigbo

    2014-01-01

    Full Text Available Despite decades of research, a full understanding of chronic kidney disease (CKD-end stage renal disease (ESRD progression remains elusive. The common consensus is a predictable, linear, progressive and time-dependent decline of CKD to ESRD. Acute kidney injury (AKI on CKD is usually assumed to be transient, with recovery as the expected outcome. AKI-ESRD association in current nephrology literature is blamed on the so-called "residual confounding." We had previously described a relationship between AKI events and rapid onset yet irreversible ESRD happening in a continuum in a high-risk CKD cohort. However, the contribution of the syndrome of rapid onset-ESRD (SORO-ESRD to incident United States ESRD population remained conjectural. In this retrospective analysis, we analyzed serum creatinine trajectories of the last 100 consecutive ESRD patients in 4 Mayo Clinic chronic hemodialysis units to determine the incidence of SORO-ESRD. Excluding 9 patients, 31 (34% patients, including two renal transplant recipients, had SORO-ESRD: 18 males and 13 females age 72 (range 50-92 years. Precipitating AKI followed pneumonia (8, acutely decompensated heart failure (7, pyelonephritis (4, post-operative (5, sepsis (3, contrast-induced nephropathy (2, and others (2. Time to dialysis was shortest following surgical procedures. Concurrent renin angiotensin aldosterone system blockade was higher with SORO-ESRD - 23% versus 5%, P = 0.0113. In conclusion, SORO-ESRD is not uncommon among the incident general US ESRD population. The implications for ESRD care planning, AV-fistula-first programs, general CKD care and any associations with renal ageing/senescence warrant further study.

  1. Prevalence and determinants of anxiety and depression in end stage renal disease (ESRD). A comparison between ESRD patients with and without coexisting diabetes mellitus.

    Science.gov (United States)

    Yoong, Russell Kl; Mooppil, Nandakumar; Khoo, Eric Yh; Newman, Stanton P; Lee, Vanessa Yw; Kang, Augustine Wc; Griva, Konstadina

    2017-03-01

    To compare anxiety and/or depressive symptoms between patients with end-stage renal disease with and without comorbid diabetes and identify factors associated with symptoms of distress in this population. Data from two studies (conducted between 2010 and 2014) were pooled. A total of 526 patients on hemodialysis (68.8% with diabetes) completed the Hospital Anxiety and Depression Scale (HADS). Elevated symptoms were defined as HADS-Anxiety or HADS-Depression≥8. Univariate and multivariate logistic regressions were used to estimate associations between diabetic status, and other socio-demographic and clinical factors with baseline clinical anxiety and depression. A total of 233 (45.4%) reported elevated anxiety symptoms and 256 (49.9%) reported elevated depressive symptoms sufficient for caseness. Rates were not different between patients with and without diabetes. Risk for clinical depression was higher in patients who were single/unpartnered (OR=1.828), Chinese vs. Malay (OR=2.05), or had lower albumin levels (OR=0.932). None of the parameters were associated with anxiety caseness. Sociocultural factors rather than comorbid burden may help identify patients at risk for depression. The high rates of anxiety and depression underlie the importance for monitoring and intervention in dialysis care. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. 透析前教育对终末期肾病患者透析时机选择的研究%Research in predialysis education for dialysis timing in patients with end-stage renal disease

    Institute of Scientific and Technical Information of China (English)

    马勤; 陈佳韵; 黄月星; 雷小华

    2011-01-01

    Objective To investigate the predialysis education on dialysis timing of patients with end-stage renal disease (ESRD). Methods 129 patients with chronic renal failure (CRF) and serum creatinine(Scr)>442μmol/L, endogenous creatinine clearance rate (Ccr)<20 ml/min were randomly divided into the experimental group(70 cases) and the control group(59 cases), the experimental group received predialysis education, the control group received routine care.The basic situation, dialysis timing, depression and quality of life on the 6th,12th months after dialysis were assessed. Results There was no significant difference in age, sex, education background, health care payment manners, employment, serum creatinine, endogenous creatinine clearance rate before education.For the timing of dialysis, Ccr for the experimental group was (9.49 ± 0.77)ml/min, Ccr for the control group was (4.54 ±1.79) ml/min,the difference was significant, depression and quality of life between two groups after 6,12 months of dialysis was also statistically different. Conclusions Strengthening predialysis education is conducive to a timely start of dialysis and can effectively improve the quality of life in patients with ESRD.%目的 研究探讨透析前教育对终末期肾病(ESRD)患者透析时机选择的影响.方法 选择血肌酐(Scr)>442μmol/L、内生肌酐清除率(Ccr)<20 ml/min的慢性肾功能衰竭(CRF)患者129例,随机分为实验组70例和对照组59例.实验组行规范化透析前教育,对照组行常规宣教.比较2组患者入组时基本状况、透析时机的选择、开始透析及透析后6,12个月的抑郁状况及生活质量.结果 2组患者入组时年龄、性别、文化程度、医疗付费方式、就业、Scr、Ccr均无显著差异,透析时机的选择实验组Ccr为(9.49±0.77)ml/min,对照组Ccr为(4.54±1.79)ml/min,2组比较有显著差异,开始透析及透后6,12个月2组的抑郁状况及生活质量比较有显著差异.结论 加强

  3. Dynamical time versus system time inquantum mechanics

    Institute of Scientific and Technical Information of China (English)

    Du(s)an Arsenovi(c); Nikola Buri(c); Dragomir Davidovi(c); Slobodan Prvanovi(c)

    2012-01-01

    Properties of an operator representing the dynamical time in the extended parameterization invariant formulation of quantum mechanics are studied.It is shown that this time operator is given by a positive operator measure analogously to the quantities that are known to represent various measurable time operators.The relation between the dynamical time of the extended formulation and the best known example of the system time operator,i.e.,for the free one-dimensional particle,is obtained.

  4. 'Stutter timing' for charge decay time measurement

    Science.gov (United States)

    Chubb, John; Harbour, John; Pavey, Ian

    2011-06-01

    The paper describes the approach of 'stutter timing' that has been developed to improve the accuracy of measuring charge decay times in the presence of noise in compact and portable charge decay test instrumentation. The approach involves starting and stopping the timing clock as the noisy signal rises above and falls below the target threshold voltage level.

  5. Time Crystals from Minimum Time Uncertainty

    CERN Document Server

    Faizal, Mir; Das, Saurya

    2016-01-01

    Motivated by the Generalized Uncertainty Principle, covariance, and a minimum measurable time, we propose a deformation of the Heisenberg algebra, and show that this leads to corrections to all quantum mechanical systems. We also demonstrate that such a deformation implies a discrete spectrum for time. In other words, time behaves like a crystal.

  6. Average-Time Games on Timed Automata

    OpenAIRE

    Jurdzinski, Marcin; Trivedi, Ashutosh

    2009-01-01

    An average-time game is played on the infinite graph of configurations of a finite timed automaton. The two players, Min and Max, construct an infinite run of the automaton by taking turns to perform a timed transition. Player Min wants to minimise the average time per transition and player Max wants to maximise it. A solution of average-time games is presented using a reduction to average-price game on a finite graph. A direct consequence is an elementary proof of determinacy for average-tim...

  7. Prothrombin time (PT)

    Science.gov (United States)

    PT; Pro-time; Anticoagulant-prothrombin time; Clotting time: protime; INR; International normalized ratio ... PT is measured in seconds. Most of the time, results are given as what is called INR ( ...

  8. Real-time systems

    OpenAIRE

    Badr, Salah M.; Bruztman, Donald P.; Nelson, Michael L.; Byrnes, Ronald Benton

    1992-01-01

    This paper presents an introduction to the basic issues involved in real-time systems. Both real-time operating sys and real-time programming languages are explored. Concurrent programming and process synchronization and communication are also discussed. The real-time requirements of the Naval Postgraduate School Autonomous Under Vehicle (AUV) are then examined. Autonomous underwater vehicle (AUV), hard real-time system, real-time operating system, real-time programming language, real-time sy...

  9. Evaluating Distributed Timing Constraints

    DEFF Research Database (Denmark)

    Kristensen, C.H.; Drejer, N.

    1994-01-01

    In this paper we describe a solution to the problem of implementing time-optimal evaluation of timing constraints in distributed real-time systems.......In this paper we describe a solution to the problem of implementing time-optimal evaluation of timing constraints in distributed real-time systems....

  10. Cherry picking in ESRD: an ethical challenge in the era of pay for performance.

    Science.gov (United States)

    Parker, J Clint

    2011-01-01

    In poorly designed pay-for-performance schemes in which case mix adjustments are not adequate, self-interest could lead nephrologists toward cherry picking dialysis patients. Cherry picking, however, is morally problematic. First, it may manifest itself as a subtle form of covert rationing which threatens to undermine patient trust. Second, it involves shifting the burden of caring for sicker (and less financially attractive) patients to other nephrologists and dialysis units that do not practice cherry picking, creating injustices in the health care system. Finally, it treats patients as mere means through which nephrologists achieve reimbursement instead of as persons possessing dignity and deserving of respect.

  11. NUTRITIONAL STATUS AND INTAKE PATTERN IN A GROUP OF ESRD SPANISH PATIENTS

    Directory of Open Access Journals (Sweden)

    Almudena Pérez Torres

    2012-06-01

    Conclusion: The undernourished patients percentage (reflected by the albumin and prealbumin increase decrease after the nutritional program. The well-nourished patients drop his weight and protein intake

  12. Validity and reliability of the Korean version of the pediatric quality of life ESRD module

    Directory of Open Access Journals (Sweden)

    Park Ki-Soo

    2012-06-01

    Full Text Available Abstract Background Health-related quality of life is a very important issue in children with end-stage renal disease and their family. Moreover, this can be a lifelong problem. In this study, we performed a cross-sectional investigation of the health-related quality of life in Korean children, undergoing renal replacement therapies, such as dialysis and renal transplantation. Findings We validated the Korean version of the PedsQL 3.0 End-Stage Renal Disease Module by comparing with the PedsQL 4.0 Generic Core Scales. A total of 92 pediatric patients with end-stage renal disease, aged 2–18 year old, were enrolled in four teaching hospitals in Korea. The module was acceptable for both parent proxy-report and child self-report. The response rate was acceptable, since no reminders were delivered. A large proportion of the responders answered >90% of the items, which suggests a good face validity. The PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 End-Stage Renal Disease Module showed minimal missing values in the current study, which supported feasibility. The validation analyses revealed acceptable floor and ceiling effects and an acceptable construct validity. Conclusions The PedsQL 3.0 End-stage Renal Disease Module may be useful as an end-stage renal disease -specific instrument in the evaluation of the health-related quality of life in Korean children; however, a larger, longitudinal prospective study is needed.

  13. Smoking and hyperparathyroidism in patients with end-stage renal disease (ESRD)

    NARCIS (Netherlands)

    G.L. Tripepi (Giovanni); F.U.S. Mattace Raso (Francesco); P. Pizzini (Patrizia); S. Cutrupi (Sebastiano); J.C.M. Witteman (Jacqueline); C. Zoccali (Carmine); F. Mallamaci (Francesca)

    2012-01-01

    textabstractBackground and methods: Smoking is associated with hyperparathyroidism in the elderly general population and nicotine, the main component of tobacco smoke, stimulates PTH release in experimental models. Although smoking is a persisting problem in patients with endstage renal disease (ESR

  14. Coexistent Pseudogout and Mycobacterium avium-intracellulare Septic Arthritis in a Patient with HIV and ESRD

    Directory of Open Access Journals (Sweden)

    Wais Afzal

    2016-01-01

    Full Text Available Pseudogout is a crystal-induced arthropathy characterized by the deposition of calcium pyrophosphate dihydrate (CPPD crystals in synovial fluid, menisci, or articular cartilage. Although not very common, this entity can be seen in patients with chronic kidney disease (CKD. Septic arthritis due to Mycobacterium avium-intracellulare (MAI is a rare entity that can affect immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS or those who are on immunosuppressive drugs. Here, we describe a 51-year-old female who presented with fever, right knee pain, swelling, warmth, and decreased range of motion for several days. The initial assessment was consistent with pseudogout, with negative bacterial and fungal cultures. However, due to high white blood cell (WBC count in the synovial fluid analysis, she was empirically started on intravenous (IV vancomycin and piperacillin-tazobactam and discharged on IV vancomycin and cefepime, while acid-fast bacilli (AFB culture was still in process. Seventeen days later, AFB culture grew Mycobacterium avium-intracellulare (MAI, and she was readmitted for relevant management. This case illustrates that septic arthritis due to MAI should be considered in the differential diagnosis of septic arthritis in immunocompromised patients.

  15. 77 FR 34047 - Medicare Program; Proposal Evaluation Criteria and Standards for End Stage Renal Disease (ESRD...

    Science.gov (United States)

    2012-06-08

    ... a growing need for facility-level data collection; analysis; monitoring; trending; evaluating and... aversion rate. 1--Vascular Access Management. Arteriovenous Fistula C.4.1.D (AVF) Monthly Improvement. 1...

  16. Mortality, malnutrition, and atherosclerosis in ESRD: what is the role of interleukin-6?

    Science.gov (United States)

    Stenvinkel, Peter; Barany, Peter; Heimbürger, Olof; Pecoits-Filho, Roberto; Lindholm, Bengt

    2002-05-01

    There is growing evidence that increased plasma concentrations of CRP strongly predict cardiovascular death in both non-renal and renal patient populations. The interleukin-6 (IL-6) system activity, which is the major mediator of the acute phase response, is often markedly up-regulated in uremic patients and has also been shown to predict outcome. This raises the issue of whether or not IL-6 per se may contribute to increased mortality from malnutrition and atherosclerotic cardiovascular disease in uremic patients. The causes of elevated IL-6 levels in the uremic circulation are not fully understood, although a number of factors prevalent in uremic patients, such as hypertension, adiposity, infections, and chronic heart failure may all contribute. However, factors associated with the dialysis procedure, such as bioincompatibility and non-sterile dialysate, may stimulate IL-6 production. Furthermore, available evidence suggests that genetic factors may also have an impact on circulating plasma IL-6 levels. We advance the hypothesis that IL-6 may play a central role in the genesis of inflammatory-driven malnutrition and that it may be regarded as a significant proatherogenic cytokine. This hypothesis may provide a rationale to test if targeted anti-cytokine therapy may be one way to combat the unacceptable high cardiovascular mortality rate among dialysis patients.

  17. Time crystals from minimum time uncertainty

    Science.gov (United States)

    Faizal, Mir; Khalil, Mohammed M.; Das, Saurya

    2016-01-01

    Motivated by the Generalized Uncertainty Principle, covariance, and a minimum measurable time, we propose a deformation of the Heisenberg algebra and show that this leads to corrections to all quantum mechanical systems. We also demonstrate that such a deformation implies a discrete spectrum for time. In other words, time behaves like a crystal. As an application of our formalism, we analyze the effect of such a deformation on the rate of spontaneous emission in a hydrogen atom.

  18. Time crystals from minimum time uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Faizal, Mir [University of Waterloo, Department of Physics and Astronomy, Waterloo, ON (Canada); Khalil, Mohammed M. [Alexandria University, Department of Electrical Engineering, Alexandria (Egypt); Das, Saurya [University of Lethbridge, Department of Physics and Astronomy, Lethbridge, AB (Canada)

    2016-01-15

    Motivated by the Generalized Uncertainty Principle, covariance, and a minimum measurable time, we propose a deformation of the Heisenberg algebra and show that this leads to corrections to all quantum mechanical systems. We also demonstrate that such a deformation implies a discrete spectrum for time. In other words, time behaves like a crystal. As an application of our formalism, we analyze the effect of such a deformation on the rate of spontaneous emission in a hydrogen atom. (orig.)

  19. Gap timing and the spectral timing model.

    Science.gov (United States)

    Hopson, J W

    1999-04-01

    A hypothesized mechanism underlying gap timing was implemented in the Spectral Timing Model [Grossberg, S., Schmajuk, N., 1989. Neural dynamics of adaptive timing and temporal discrimination during associative learning. Neural Netw. 2, 79-102] , a neural network timing model. The activation of the network nodes was made to decay in the absence of the timed signal, causing the model to shift its peak response time in a fashion similar to that shown in animal subjects. The model was then able to accurately simulate a parametric study of gap timing [Cabeza de Vaca, S., Brown, B., Hemmes, N., 1994. Internal clock and memory processes in aminal timing. J. Exp. Psychol.: Anim. Behav. Process. 20 (2), 184-198]. The addition of a memory decay process appears to produce the correct pattern of results in both Scalar Expectancy Theory models and in the Spectral Timing Model, and the fact that the same process should be effective in two such disparate models argues strongly that process reflects a true aspect of animal cognition.

  20. Shackle in time - time in Shackle

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2015-01-01

    GLS Shackle got much and the crucial inspiration from John Maynard Keynes. But that's not all. He took a number of further consequences of Keynes’ thoughts. This implies for example ideal claims to economists - having to deal with both mechanical time and expectational time. In consequence the idea...

  1. Shackle in TimeTime in Shackle

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2016-01-01

    GLS Shackle got much and the crucial inspiration from John Maynard Keynes. But that’s not all. He took a number of further consequences of Keynes’ thoughts. This implies for example ideal claims to economists — having to deal with both mechanical time and expectational time. In consequence the idea...

  2. Intelligence, Inspection Time, and Decision Time.

    Science.gov (United States)

    Bates, Timothy C.; Eysenck, Hans J.

    1993-01-01

    Relationships among Multidimensional Aptitude Battery scores, inspection time, choice reaction time, and the odd-man procedure were investigated for 63 female and 25 male adults. No significant relationships were found for these mental speed measures and the Eysenck Personality Questionnaire-Revised dimensions of extraversion, neuroticism, and…

  3. Time Crystals: a review.

    Science.gov (United States)

    Sacha, Krzysztof; Zakrzewski, Jakub

    2017-09-08

    Time crystals are time-periodic self-organized structures postulated by Frank Wilczek in 2012. While the original concept was strongly criticized, it stimulated at the same time an intensive research leading to propositions and experimental verifications of discrete (or Floquet) time crystals -- the structures that appear in the time domain due to spontaneous breaking of discrete time translation symmetry. The struggle to observe discrete time crystals is reviewed here together with propositions that generalize this concept introducing condensed matter like physics in the time domain. We shall also revisit the original Wilczek's idea and review strategies aimed at spontaneous breaking of continuous time translation symmetry. . © 2017 IOP Publishing Ltd.

  4. Time in antiquity

    CERN Document Server

    Hannah, Robert

    2008-01-01

    Time in Antiquity explores the different perceptions of time from Classical antiquity, principally through the technology designed to measure, mark or tell time. The material discussed ranges from the sixth century BC in archaic Greece to the 3rd century AD in the Roman Empire, and offers fascinating insights into ordinary people's perceptions of time and time-keeping instruments.

  5. Algebra of timed frames

    NARCIS (Netherlands)

    Bergstra, J.A.; Fokkink, W.J.; Middelburg, C.A.

    2008-01-01

    Timed frames are introduced as objects that can form a basis of a model theory for discrete time process algebra. An algebraic setting for timed frames is proposed and results concerning its connection with discrete time process algebra are given. The presented theory of timed frames captures the ba

  6. Discrete time process algebra

    NARCIS (Netherlands)

    Bergstra, J.A.; Baeten, J.C.M.

    1996-01-01

    The axiom system ACP of [BeK84a] was extended with real time features in [BaB91]. Here we proceed to define a discrete time extension of ACP, along the lines of ATP [NiS94]. We present versions based on relative timing and on absolute timing. Both approaches are integrated using parametric timing. T

  7. Continuous-time signals

    CERN Document Server

    Shmaliy, Yuriy

    2006-01-01

    Gives a modern description of continuous-time deterministic signals Signal formation techniquesTime vs. frequency and frequency vs. time analysisCorrelation and energy analysisNarrowband signals and sampling.

  8. On Time. 6b: Quantum Mechanical Time

    CERN Document Server

    Raju, C K

    2008-01-01

    The existence of small amounts of advanced radiation, or a tilt in the arrow of time, makes the basic equations of physics mixed-type functional differential equations. The novel features of such equations point to a microphysical structure of time. This corresponds to a change of logic at the microphysical level. We show that the resulting logic is a quantum logic. This provides a natural and rigorous explanation of quantum interference. This structured-time interpretation of quantum mechanics is briefly compared with various other interpretations of q.m.

  9. Did time begin? Will time end?

    OpenAIRE

    Frampton, Paul H.

    2007-01-01

    Did time begin at a Big Bang? Will the present expansion of the universe last for a finite or infinite time? These questions sound philosophical but are becoming, now in the twenty-first century, central to the scientific study of cosmology. The answers, which should become clarified in the next decade or two, could have profound implications for how we see our own role in the universe. Since the original publication of Stephen Hawking's {\\it A Brief History of Time} in 1988, the answers to t...

  10. Is Time Predictability Quantifiable?

    DEFF Research Database (Denmark)

    Schoeberl, Martin

    2012-01-01

    -case execution time. To compare different approaches we would like to quantify time predictability. That means we need to measure time predictability. In this paper we discuss the different approaches for these measurements and conclude that time predictability is practically not quantifiable. We can only......Computer architects and researchers in the realtime domain start to investigate processors and architectures optimized for real-time systems. Optimized for real-time systems means time predictable, i.e., architectures where it is possible to statically derive a tight bound of the worst...... compare the worst-case execution time bounds of different architectures....

  11. On Time-II: Newton's Time.

    Science.gov (United States)

    Raju, C. K.

    1991-01-01

    A study of time in Newtonian physics is presented. Newton's laws of motion, falsifiability and physical theories, laws of motion and law of gravitation, and Laplace's demon are discussed. Short bibliographic sketches of Laplace and Karl Popper are included. (KR)

  12. Proper Time in Weyl space-time

    CERN Document Server

    Avalos, R; Romero, C

    2016-01-01

    We discuss the question of whether or not a general Weyl structure is a suitable mathematical model of space-time. This is an issue that has been in debate since Weyl formulated his unified field theory for the first time. We do not present the discussion from the point of view of a particular unification theory, but instead from a more general standpoint, in which the viability of such a structure as a model of space-time is investigated. Our starting point is the well known axiomatic approach to space-time given by Elhers, Pirani and Schild (EPS). In this framework, we carry out an exhaustive analysis of what is required for a consistent definition for proper time and show that such a definition leads to the prediction of the so-called "second clock effect". We take the view that if, based on experience, we were to reject space-time models predicting this effect, this could be incorporated as the last axiom in the EPS approach. Finally, we provide a proof that, in this case, we are led to a Weyl integrable ...

  13. Did time begin? Will time end?

    CERN Document Server

    Frampton, Paul H

    2009-01-01

    Did time begin at a Big Bang? Will the present expansion of the universe last for a finite or infinite time? These questions sound philosophical but are becoming, now in the twenty-first century, central to the scientific study of cosmology. The answers, which should become clarified in the next decade or two, could have profound implications for how we see our own role in the universe. Since the original publication of Stephen Hawking's {\\it A Brief History of Time} in 1988, the answers to these questions have progressed as a result of research by the community of active theoretical physicists including myself. To present the underlying ideas requires discussion of a wide range of topics in cosmology, especially the make up of the energy content of the universe. A brief summary of my conclusions, that of three different possibilities concerning the history and future of time, the least likely is the conventional wisdom (time began and will never end) and most likely is a cyclic model (time never begins or en...

  14. Talk of time

    Directory of Open Access Journals (Sweden)

    Johann-Albrecht Meylahn

    2015-03-01

    Full Text Available Maybe, before we speak of time, or maybe whilst we are speaking of time, or maybe after we have spoken of time, in the various modes of time’s insistence to exist, one should give time to the talk of time. There are various different modes of time’s insistence to exist, such as quantum physics in conversation with relativity theory where time is constructed as a fourth dimension of space. Or there are the modes of time in history, religion, psychology and philosophy, and each of these modes is composed, and composes its own specific object called time, and a particular subject who understands and interprets time in that particular mode. Yet, before, whilst or after these modes of time’s insistence to exist, one should maybe give time to time’s time. Give time for the various times to articulate themselves in the various modes of existence, thereby creating both a whole plurality of differing subjects, as well as plurality of differing objects, all called ‘time’. Once time has been given time to talk its talk, to articulate itself within the various modes, it will be interrupted by the articulations of time in various modes of time still to come. These disruptions of time by time always still to come opens the door for a theological narrative – a narrative on time, but created by the coming of messianic times, interpreted in the mode of hope but also in the mode of a promise from the past.

  15. Time Management for Directors

    Science.gov (United States)

    Jaffe, Ellen Hofstetter

    2005-01-01

    Time management is a skill. Like any new skill, it takes time and commitment to develop. A frequent complaint of center directors is not having enough time. Most work extremely long hours and still feel they are not getting enough done. This article presents ideas on how to manage time and work smarter, not harder. These ideas are the following:…

  16. THE VALUE OF TIME

    Institute of Scientific and Technical Information of China (English)

    甘雨

    2002-01-01

    Some people said,"Time is money". but I think time is more precous than money, We can earn more money when we've spent some, but lost time can never be found again, I think that the life of a person is made up of time.

  17. Time and Teaching

    Science.gov (United States)

    McEwan, Anna E.

    2012-01-01

    This essay invites reflection on the phenomena of time as it impacts the day-to-day life of teachers. It also explores assumptions about time and teaching in three areas: first, beliefs about the force of time and the teacher's struggle to control it; second, beliefs about the potential of time and the benefits of its passing for teachers and…

  18. Elementary cycles of time

    Directory of Open Access Journals (Sweden)

    Dolce Donatello

    2013-09-01

    Full Text Available Elementary particles, i.e. the basic constituents of nature, are characterized by quantum recurrences in time. The flow of time of every physical system can be therefore decomposed in elementary cycles of time. This allows us to enforce the local nature of relativistic time, yielding interesting unified descriptions of fundamental aspects of modern physics, as shown in recent publications. Every particle can be regarded as a reference clock with time resolution of the order of the Compton time particle, many orders of magnitude more accurate than the atomic clocks. Here we report basic implications about the resulting notion of time.

  19. Time in quantum mechanics

    CERN Document Server

    Mayato, R; Egusquiza, I

    2002-01-01

    The treatment of time in quantum mechanics is still an important and challenging open question in the foundation of the theory. This book describes the problems, and the attempts and achievements in defining, formalizing and measuring different time quantities in quantum theory, such as the parametric (clock) time, tunneling times, decay times, dwell times, delay times, arrival times or jump times. This multiauthored book, written as an introductory guide for the non-initiated as well as a useful source of information for the expert, covers many of the open questions. A brief historical overview is to be found in the introduction. It is followed by 12 chapters devoted to conceptual and theoretical investigations as well as experimental issues in quantum-mechanical time measurements. This unique monograph should attract physicists as well as philosophers of science working in the foundations of quantum physics.

  20. Time in quantum cosmology

    CERN Document Server

    Bojowald, Martin

    2016-01-01

    A cosmological model with two global internal times shows that time reparameterization invariance, and therefore covariance, is not guaranteed by deparameterization. In particular, it is impossible to derive proper-time effective equations from a single deparameterized model if quantum corrections from fluctuations and higher moments are included. The framework of effective constraints shows how proper-time evolution can consistently be defined in quantum cosmological systems, such that it is time reparameterization invariant when compared with other choices of coordinate time. At the same time, it allows transformations of moment corrections in different deparameterizations of the same model, indicating partial time reparameterization of internal-time evolution. However, in addition to corrections from moments such as quantum fluctuations, also factor ordering corrections may appear. The latter generically break covariance in internal-time formulations. Fluctuation effects in quantum cosmology are therefore ...

  1. Cosmology and time

    Directory of Open Access Journals (Sweden)

    Balbi Amedeo

    2013-09-01

    Full Text Available Time has always played a crucial role in cosmology. I review some of the aspects of the present cosmological model which are more directly related to time, such as: the definition of a cosmic time; the existence of typical timescales and epochs in an expanding universe; the problem of the initial singularity and the origin of time; the cosmological arrow of time.

  2. Right about time?

    CERN Document Server

    Gryb, Sean

    2013-01-01

    Have our fundamental theories got time right? Does size really matter? Or is physics all in the eyes of the beholder? In this essay, we question the origin of time and scale by reevaluating the nature of measurement. We then argue for a radical scenario, supported by a suggestive calculation, where the flow of time is inseparable from the measurement process. Our scenario breaks the bond of time and space and builds a new one: the marriage of time and scale.

  3. Neuropharmacology of timing and time perception.

    Science.gov (United States)

    Meck, W H

    1996-06-01

    Time is a guiding force in the behavior of all organisms. For both a rat in an experimental setting (e.g. Skinner box) trying to predict when reinforcement will be delivered and a human in a restaurant waiting for his dinner to be served an accurate perception of time is an important determinant of behavior. Recent research has used a combination of pharmacological and behavioral manipulations to gain a fuller understanding of how temporal information is processed. A psychological model of duration discrimination that differentiates the speed of an internal clock used for the registration of current sensory input from the speed of the memory-storage process used for the representation of the durations of prior stimulus events has proven useful in integrating these findings. Current pharmacological research suggests that different stages of temporal processing may involve separate brain regions and be modified by different neurotransmitter systems. For example, the internal clock used to time durations in the seconds-to-minutes range appears linked to dopamine (DA) function in the basal ganglia, while temporal memory and attentional mechanisms appear linked to acetylcholine (ACh) function in the frontal cortex. These two systems are connected by frontal-striatal loops, thus allowing for the completion of the timing sequences involved in duration discrimination.

  4. Choosing between his time and her time?

    DEFF Research Database (Denmark)

    Deding, Mette; Lausten, Mette

    When adding up market work and non-market work, Danish men and women work about the same number of hours per day. While men do the major share of the market work, women do the major share of the non-market work. In this paper, we investigate the interaction between the different time use activities...

  5. Choosing between his time and her time?

    DEFF Research Database (Denmark)

    Deding, Mette; Lausten, Mette

    When adding up market work and non-market work, Danish men and women work about the same number of hours per day. While men do the major share of the market work, women do the major share of the non-market work. In this paper, we investigate the interaction between the different time use activiti...

  6. The direction of time

    CERN Document Server

    Reichenbach, Hans

    1999-01-01

    Ever a source of philosophical conjecture and debate, the concept of time represents the beating heart of physics. This final work by the distinguished physicist Hans Reichenbach represents the culmination and integration of a lifetime's philosophical contributions and inquiries into the analysis of time. The result is an outstanding overview of such qualitative, or topological, attributes of time as order and direction.Beginning with a discussion of the emotive significance of time, Reichenbach turns to an examination of the time order of mechanics, the time direction of thermodynamics and m

  7. Time amplifying techniques towards atomic time resolution

    Institute of Scientific and Technical Information of China (English)

    LI JingZhen

    2009-01-01

    High speed imaging technology has opened applications in many fields,such as collision,detonating,high voltage discharge,disintegration and transfer of phonon and exciton in solid,photosynthesis primitive reaction,and electron dynamics inside atom shell.In principle,all of the transient processes need to be explained theoretically and,st the same time,the time amplifying technique is required for observations of these processes.The present review concerns the atomic time amplifying mechanism of optical information and the extremely-high speed imaging methods,which are expressed in terms of the short time amplifying techniques.It is well-known that for extremely-high speed imaging with the converter tube,the temporal resolution is in the order of sub-picosecond of the streak imaging,and the imaging frequency is 6×10~8-5×10~9 fps(frame per second)of the frame imaging.On the other hand,for the tubeless extremely-high speed imaging,the imaging frequency is 10~7-10~(14) fps,and its mechanism of forming high speed and framing could involve a lot of factors of the light under investigation,for instance,light speed,light parallelism,the parameters of light wave such as amplitude,phase,polarization and wavelength,and even quantum properties of photon.In the cascaded system of electromagnetic wave and particle wave,it is possible to simultaneously realize extremely-high resolution in time and space,which is higher than a kite resolution.Then it would be possible to break the limit of the Heisenberg uncertainty relation of the optical frequency band.

  8. Time amplifying techniques towards atomic time resolution

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    High speed imaging technology has opened applications in many fields,such as collision,detonating, high voltage discharge,disintegration and transfer of phonon and exciton in solid,photosynthesis primitive reaction,and electron dynamics inside atom shell.In principle,all of the transient processes need to be explained theoretically and,at the same time,the time amplifying technique is required for observations of these processes.The present review concerns the atomic time amplifying mechanism of optical information and the extremely-high speed imaging methods,which are expressed in terms of the short time amplifying techniques.It is well-known that for extremely-high speed imaging with the converter tube,the temporal resolution is in the order of sub-picosecond of the streak imaging,and the imaging frequency is 6×10 8 ―5×10 9 fps(frame per second)of the frame imaging.On the other hand,for the tubeless extremely-high speed imaging,the imaging frequency is 10 7 ―10 14 fps,and its mechanism of forming high speed and framing could involve a lot of factors of the light under investigation,for instance,light speed,light parallelism,the parameters of light wave such as amplitude,phase,polari- zation and wavelength,and even quantum properties of photon.In the cascaded system of electro- magnetic wave and particle wave,it is possible to simultaneously realize extremely-high resolution in time and space,which is higher than a kite resolution.Then it would be possible to break the limit of the Heisenberg uncertainty relation of the optical frequency band.

  9. Beam Synchronous Timing Systems

    CERN Document Server

    Peters, A

    2003-01-01

    For many beam diagnostics purposes beam synchronous timing systems are needed in addition to the timing systems supplied by the control systems of the different accelerators. The demands and techniques of different accelerator facilities will be discussed along the following aspects: Bunch and macro pulse synchronous timing systems Solutions for different time scales from ps to ms Coupling to the RF and control systems of the different accelerators Electronics for the beam synchronous timing systems: parameters, techniques, controlling Use of industrial products for bunch synchronous timing systems, e.g. function generators Distribution of the timing signals: electronically via cables, optically via fibres or wireless Coupling to and use of timing standards: IRIG-B, GPS, ? The participants should present and describe solutions from their facilities with some transparencies as a starting point for the discussion.

  10. Children, Time, and Play

    DEFF Research Database (Denmark)

    Elkind, David; Rinaldi, Carla; Flemmert Jensen, Anne;

    Proceedings from the conference "Children, Time, and Play". Danish University of Education, January 30th 2003.......Proceedings from the conference "Children, Time, and Play". Danish University of Education, January 30th 2003....

  11. Successful time management

    CERN Document Server

    Forsyth, Patrick

    2016-01-01

    Packed with tips and techniques, Successful Time Management serves as a guide to reviewing and assessing new work practices to improve time management. It includes great time-saving ideas, practical solutions, checklists, and advice on controlling paperwork, delegating and working with others, prioritizing to focus on key issues, and getting and staying organized. This new third edition contains new practical tips on using email in a time effective manner and dealing with other internet-based tools and apps to help productivity.

  12. Time management and procrastination

    OpenAIRE

    van Eerde, W.; Mumford, M.D.; Frese, M.

    2015-01-01

    This chapter combines the topics time management and procrastination. Time management is an overarching term derived from popular notions on how to be effective at work. Procrastination has been mainly researched from a personality perspective, addressing the emotional and psychological issues of the phenomenon in more detail. First, I describe time management and procrastination, and next I address interventions that may help people in overcoming procrastination. Studies on time management s...

  13. Enhanced time overcurrent coordination

    Energy Technology Data Exchange (ETDEWEB)

    Enriquez, Arturo Conde; Martinez, Ernesto Vazquez [Universidad Autonoma de Nuevo Leon, Facultad de Ingenieria Mecanica y Electrica, Apdo. Postal 114-F, Ciudad Universitaria, CP 66450 San Nicolas de los Garza, Nuevo Leon (Mexico)

    2006-04-15

    In this paper, we recommend a new coordination system for time overcurrent relays. The purpose of the coordination process is to find a time element function that allows it to operate using a constant back-up time delay, for any fault current. In this article, we describe the implementation and coordination results of time overcurrent relays, fuses and reclosers. Experiments were carried out in a laboratory test situation using signals of a power electrical system physics simulator. (author)

  14. Time banking som ledelsesteknologi

    OpenAIRE

    Steensberg, Maja; Nielsen, Nadia Holm; Thomsen, Søren Tolshave

    2014-01-01

    This project examines how the English time banks Timber Wharf, Echo and Fair Shares affect their members and local environments. Based on Nikolas Rose’s theory on governmentality it is discussed, whether the time banks, understood as political actors, are challenging or reproducing neo-liberal governance. It is concluded that the way the time banks facilitates the concept of timebanking differs greatly. These different conducts are shaping the way in which the time banks are used by their mem...

  15. Continuous Time Model Estimation

    OpenAIRE

    Carl Chiarella; Shenhuai Gao

    2004-01-01

    This paper introduces an easy to follow method for continuous time model estimation. It serves as an introduction on how to convert a state space model from continuous time to discrete time, how to decompose a hybrid stochastic model into a trend model plus a noise model, how to estimate the trend model by simulation, and how to calculate standard errors from estimation of the noise model. It also discusses the numerical difficulties involved in discrete time models that bring about the unit ...

  16. Modelling urban travel times

    NARCIS (Netherlands)

    Zheng, F.

    2011-01-01

    Urban travel times are intrinsically uncertain due to a lot of stochastic characteristics of traffic, especially at signalized intersections. A single travel time does not have much meaning and is not informative to drivers or traffic managers. The range of travel times is large such that certain tr

  17. Time series analysis.

    NARCIS (Netherlands)

    2013-01-01

    Time series analysis can be used to quantitatively monitor, describe, explain, and predict road safety developments. Time series analysis techniques offer the possibility of quantitatively modelling road safety developments in such a way that the dependencies between the observations of time series

  18. Modelling urban travel times

    NARCIS (Netherlands)

    Zheng, F.

    2011-01-01

    Urban travel times are intrinsically uncertain due to a lot of stochastic characteristics of traffic, especially at signalized intersections. A single travel time does not have much meaning and is not informative to drivers or traffic managers. The range of travel times is large such that certain

  19. The Language of Time.

    Science.gov (United States)

    Friederwitzer, Fredda J.; Berman, Barbara

    1999-01-01

    Presents concrete time-teaching models to teach about making connections to fractions and measurement in which students literally measure time by using Cuisenaire rods on a form of number line to discover the meaning of the language used to describe the passing of time. (ASK)

  20. Keeping time - Performing Place

    DEFF Research Database (Denmark)

    Dvinge, Anne Christine

    2012-01-01

    and reactionary and suggests that the way time is employed in a heterotopic space determines its progressive potential. Spaces of accumulative, static, or frozen time refuse to yield any utopian promise, whereas fluid, dynamic, and ephemeral time offers moments of agency. In the case of Valaida, music...

  1. Screen time and children

    Science.gov (United States)

    ... obesity ) Screen time increases your child's risk of obesity because: Sitting and watching a screen is time that is not spent being physically active. TV commercials and other screen ads can lead to unhealthy food choices . Most of the time, the foods in ads ...

  2. Toddler Reading Time

    Science.gov (United States)

    ... Your 1- to 2-Year-Old Toddler Reading Time KidsHealth > For Parents > Toddler Reading Time A A A What's in this article? Reasons ... Kids make big leaps in vocabulary during this time, and learn about letters, shapes, colors, weather, animals, ...

  3. America's Family Time Famine.

    Science.gov (United States)

    Mattox, Jr., William R.

    1990-01-01

    Parents spend increasingly less time with their children because of the pressures of dual careers and single parenthood. Economic pressures and social values have affected sharing of family time. Studies show both parents and children consider spending time together the most important element in improving family life. (BC)

  4. BIPM Time Activities Update

    Science.gov (United States)

    2009-11-01

    published on the ftp server of the Time, Frequency, and Gravimetry Department of the BIPM [16]. With the aim of introducing GLONASS observations for clock...implemented for the calculation of time links in the BIPM Time, Frequency, and Gravimetry Department in order to improve and refine TAI calculation. For

  5. Modelling urban travel times

    NARCIS (Netherlands)

    Zheng, F.

    2011-01-01

    Urban travel times are intrinsically uncertain due to a lot of stochastic characteristics of traffic, especially at signalized intersections. A single travel time does not have much meaning and is not informative to drivers or traffic managers. The range of travel times is large such that certain tr

  6. Parametric Timing Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Vivancos, E; Healy, C; Mueller, F; Whalley, D

    2001-05-09

    Embedded systems often have real-time constraints. Traditional timing analysis statically determines the maximum execution time of a task or a program in a real-time system. These systems typically depend on the worst-case execution time of tasks in order to make static scheduling decisions so that tasks can meet their deadlines. Static determination of worst-case execution times imposes numerous restrictions on real-time programs, which include that the maximum number of iterations of each loop must be known statically. These restrictions can significantly limit the class of programs that would be suitable for a real-time embedded system. This paper describes work-in-progress that uses static timing analysis to aid in making dynamic scheduling decisions. For instance, different algorithms with varying levels of accuracy may be selected based on the algorithm's predicted worst-case execution time and the time allotted for the task. We represent the worst-case execution time of a function or a loop as a formula, where the unknown values affecting the execution time are parameterized. This parametric timing analysis produces formulas that can then be quickly evaluated at run-time so dynamic scheduling decisions can be made with little overhead. Benefits of this work include expanding the class of applications that can be used in a real-time system, improving the accuracy of dynamic scheduling decisions, and more effective utilization of system resources. This paper describes how static timing analysis can be used to aid in making dynamic scheduling decisions. The WCET of a function or a loop is represented as a formula, where the values affecting the execution time are parameterized. Such formulas can then be quickly evaluated at run-time so dynamic scheduling decisions can be made when scheduling a task or choosing algorithms within a task. Benefits of this parametric timing analysis include expanding the class of applications that can be used in a real-time

  7. Mexican American Women's Adherence to Hemodialysis Treatment: A Social Constructivist Perspective

    Science.gov (United States)

    Tijerina, Mary S.

    2009-01-01

    Mexican Americans have as much as a six-times greater risk of end-stage renal disease (ESRD) than non-Hispanic white Americans, and women show a faster rate of decline in diabetic renal functioning. The leading treatment for ESRD is hemodialysis, an intensive, complex treatment regimen associated with high levels of patient nonadherence. Previous…

  8. Mexican American Women's Adherence to Hemodialysis Treatment: A Social Constructivist Perspective

    Science.gov (United States)

    Tijerina, Mary S.

    2009-01-01

    Mexican Americans have as much as a six-times greater risk of end-stage renal disease (ESRD) than non-Hispanic white Americans, and women show a faster rate of decline in diabetic renal functioning. The leading treatment for ESRD is hemodialysis, an intensive, complex treatment regimen associated with high levels of patient nonadherence. Previous…

  9. Time and man

    CERN Document Server

    Elton, LRB

    2014-01-01

    Time and Man focuses on the endeavors of humans to probe the mysteries of time and to elucidate its properties. The discussions are both philosophical and factual in nature and encompass science as well as the physical sciences, biology and related disciplines (for example, evolution), and the humanities (for example, religion). Factual information is presented to help the reader gain a better understanding of the concepts associated with time.Comprised of nine chapters, this volume first considers the passage of time and the experiences which humans associate with the concept of time before r

  10. Time and man

    CERN Document Server

    Elton, L. R. B

    1978-01-01

    Time and Man focuses on the endeavors of humans to probe the mysteries of time and to elucidate its properties. The discussions are both philosophical and factual in nature and encompass science as well as the physical sciences, biology and related disciplines (for example, evolution), and the humanities (for example, religion). Factual information is presented to help the reader gain a better understanding of the concepts associated with time.Comprised of nine chapters, this volume first considers the passage of time and the experiences which humans associate with the concept of time before r

  11. Time a traveler's guide

    CERN Document Server

    Pickover, Clifford A

    1998-01-01

    ""Bucky Fuller thought big,"" Wired magazine recently noted, ""Arthur C. Clarke thinks big, but Cliff Pickover outdoes them both."" In his newest book, Cliff Pickover outdoes even himself, probing a mystery that has baffled mystics, philosophers, and scientists throughout history--What is the nature of time? In Time: A Traveler's Guide, Pickover takes readers to the forefront of science as he illuminates the most mysterious phenomenon in the universe--time itself. Is time travel possible? Is time real? Does it flow in one direction only? Does it have a beginning and an end? What is eternity? P

  12. Stable Flows over Time

    Directory of Open Access Journals (Sweden)

    Jannik Matuschke

    2013-08-01

    Full Text Available In this paper, the notion of stability is extended to network flows over time. As a useful device in our proofs, we present an elegant preflow-push variant of the Gale-Shapley algorithm that operates directly on the given network and computes stable flows in pseudo-polynomial time, both in the static flow and the flow over time case. We show periodical properties of stable flows over time on networks with an infinite time horizon. Finally, we discuss the influence of storage at vertices, with different results depending on the priority of the corresponding holdover edges.

  13. Buying time promotes happiness.

    Science.gov (United States)

    Whillans, Ashley V; Dunn, Elizabeth W; Smeets, Paul; Bekkers, Rene; Norton, Michael I

    2017-08-08

    Around the world, increases in wealth have produced an unintended consequence: a rising sense of time scarcity. We provide evidence that using money to buy time can provide a buffer against this time famine, thereby promoting happiness. Using large, diverse samples from the United States, Canada, Denmark, and The Netherlands (n = 6,271), we show that individuals who spend money on time-saving services report greater life satisfaction. A field experiment provides causal evidence that working adults report greater happiness after spending money on a time-saving purchase than on a material purchase. Together, these results suggest that using money to buy time can protect people from the detrimental effects of time pressure on life satisfaction.

  14. Early times in tunneling

    CERN Document Server

    García-Calderón, G; Garcia-Calderon, Gaston; Villavicencio, Jorge

    2000-01-01

    Exact analytical solutions of the time-dependent Schr\\"odinger equation with the initial condition of an incident cutoff wave are used to investigate the traversal time for tunneling. The probability density starts from a vanishing value along the tunneling and transmitted regions of the potential. At the barrier width it exhibits, at early times, a distribution of traversal times that typically has a peak $\\tau_p$ and a width $\\Delta \\tau$. Numerical results for other tunneling times, as the phase-delay time, fall within $\\Delta \\tau$. The B\\"uttiker traversal time is the closest to $\\tau_p$. Our results resemble calculations based on Feynman paths if its noisy behaviour is ignored.

  15. Time scales in LISA

    CERN Document Server

    Pireaux, S

    2007-01-01

    The LISA mission is a space interferometer aiming at the detection of gravitational waves in the [$10^{-4}$,$10^{-1}$] Hz frequency band. In order to reach the gravitational wave detection level, a Time Delay Interferometry (TDI) method must be applied to get rid of (most of) the laser frequency noise and optical bench noise. This TDI analysis is carried out in terms of the coordinate time corresponding to the Barycentric Coordinate Reference System (BCRS), TCB, whereas the data at each of the three LISA stations is recorded in terms of each station proper time. We provide here the required proper time versus BCRS time transformation. We show that the difference in rate of station proper time versus TCB is of the order of $5 10^{-8}$. The difference between station proper times and TCB exhibits an oscillatory trend with a maximum amplitude of about $10^{-3}$ s.

  16. The River of Time

    Science.gov (United States)

    Novikov, Igor D.

    1998-09-01

    The nature of time has long fascinated physicists and lay people alike. As an irresistible flow into which all events are embedded, time cannot be slowed or accelerated. It cannot be undone or turned back. In this marvelous text, Novikov describes how the thinkers throughout history have defined time and how these discoveries demonstrate that we may influence time's flow. He details the development of our views on time, from classical Greece to the modern day. This book describes how time flows in specific regions of the Universe, how it stops in black holes and splashes over the brim in white holes, and how time may convert into space and vice versa. The author explores time's genesis at the Big Bang and describes the current research on the physics of time. He details how recent discoveries indicate that time machine travel might be possible. Accessible to all, the engaging style and wonderful illustrations make this book hugely enjoyable to read. Igor Novikov is the author of Evolution of the Universe (Cambridge, 1983), Black Holes and the Universe (Cambridge, 1990), and E. Hubble, Life and Work (Cambridge, 1992). His extensive body of research begins in the former Soviet Union and his experiences add a unique touch to this book. Currently, he is the Director of the Theoretical Astrophysics Center in Copenhagen.

  17. Biomarker time out.

    Science.gov (United States)

    Petzold, Axel; Bowser, Robert; Calabresi, Paolo; Zetterberg, Henrik; Uitdehaag, Bernard M J

    2014-10-01

    The advancement of knowledge relies on scientific investigations. The timing between asking a question and data collection defines if a study is prospective or retrospective. Prospective studies look forward from a point in time, are less prone to bias and are considered superior to retrospective studies. This conceptual framework conflicts with the nature of biomarker research. New candidate biomarkers are discovered in a retrospective manner. There are neither resources nor time for prospective testing in all cases. Relevant sources for bias are not covered. Ethical questions arise through the time penalty of an overly dogmatic concept. The timing of sample collection can be separated from testing biomarkers. Therefore the moment of formulating a hypothesis may be after sample collection was completed. A conceptual framework permissive to asking research questions without the obligation to bow to the human concept of calendar time would simplify biomarker research, but will require new safeguards against bias.

  18. Leisure Time Invention

    DEFF Research Database (Denmark)

    Davis, Lee N.; Davis, Jerome D.; Hoisl, Karin

    2013-01-01

    This paper studies the contextual factors that influence whether invention occurs during work time or leisure time. Leisure time invention, a potentially important but thus far largely unexplored source of employee creativity, refers to invention where the main underlying idea occurs while...... by adding to the discussion of how access to and exploitation of different types of resources—during work hours or during leisure time — may affect creativity. Based on survey data from more than 3,000 inventions from German employee inventors, we find that leisure time inventions are more frequently...... observed for conceptually based problems, in cases where interactions with people outside the organization are important for making the invention, and for smaller research and development projects. Our findings also suggest that employee inventions during work time may become more “embedded...

  19. Peircean diagrams of time

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2011-01-01

    Some very good arguments can be given in favor of the Augustinean wisdom, according to which it is impossible to provide a satisfactory definition of the concept of time. However, even in the absence of a proper definition, it is possible to deal with conceptual problems regarding time. It can...... be done in terms of analogies and metaphors. In particular, it is attractive to make use of Peirce's diagrams by means of which various kinds of conceptual experimentation can be carried out. This paper investigates how Peircean diagrams can be used within the study of time. In particular, we discuss 1......) the topological properties of time, 2) the implicative structure in tense logic, 3) the notions of open future and branching time models, and finally 4) tenselogical alternatives to branching time models....

  20. The Oppressor School Time

    Directory of Open Access Journals (Sweden)

    Nuno Vieira

    2013-11-01

    Full Text Available Time conceptions have had an evolution along the time, defining itself as one key element for both social and scientific activities. Nowadays time studies does not belong to a specific scientific subject, it has a multi-referential status and its study must be based on multidisciplinary perspectives. Even our circadian times are ruled by external entities such as work, and we learn to walk by the (temporal rhythms at school. Time rulers, like clocks, bells, rings, defines our lives and the way we live them, undertaken by a global synchronism. This synchronic activities oppresses (Freire our lives because it overrules our inner time and dictates the way we live in the moment that we start going to school.

  1. [Time perceptions and representations].

    Science.gov (United States)

    Tordjman, S

    2015-09-01

    Representations of time and time measurements depend on subjective constructs that vary according to changes in our concepts, beliefs, societal needs and technical advances. Similarly, the past, the future and the present are subjective representations that depend on each individual's psychic time and biological time. Therefore, there is no single, one-size-fits-all time for everyone, but rather a different, subjective time for each individual. We need to acknowledge the existence of different inter-individual times but also intra-individual times, to which different functions and different rhythms are attached, depending on the system of reference. However, the construction of these time perceptions and representations is influenced by objective factors (physiological, physical and cognitive) related to neuroscience which will be presented and discussed in this article. Thus, studying representation and perception of time lies at the crossroads between neuroscience, human sciences and philosophy. Furthermore, it is possible to identify several constants among the many and various representations of time and their corresponding measures, regardless of the system of time reference. These include the notion of movements repeated in a stable rhythmic pattern involving the recurrence of the same interval of time, which enables us to define units of time of equal and invariable duration. This rhythmicity is also found at a physiological level and contributes through circadian rhythms, in particular the melatonin rhythm, to the existence of a biological time. Alterations of temporality in mental disorders will be also discussed in this article illustrated by certain developmental disorders such as autism spectrum disorders. In particular, the hypothesis will be developed that children with autism would need to create discontinuity out of continuity through stereotyped behaviors and/or interests. This discontinuity repeated at regular intervals could have been

  2. Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients.

    Science.gov (United States)

    Di Pietro, Natalia; Giardinelli, Annalisa; Sirolli, Vittorio; Riganti, Chiara; Di Tomo, Pamela; Gazzano, Elena; Di Silvestre, Sara; Panknin, Christina; Cortese-Krott, Miriam M; Csonka, Csaba; Kelm, Malte; Ferdinandy, Péter; Bonomini, Mario; Pandolfi, Assunta

    2016-06-01

    Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced in end-stage renal disease (ESRD) and associated with endothelial dysfunction. We previously demonstrated that, through increased phosphatidylserine membrane exposure, ESRD-RBCs augmented their adhesion to human cultured endothelium, in which NO bioavailability decreased. Since RBC-NOS-dependent NO production in ESRD is unknown, this study aimed to investigate RBC-NOS levels/activation, NO production/bioavailability in RBCs from healthy control subjects (C, N = 18) and ESRD patients (N = 27). Although RBC-NOS expression was lower in ESRD-RBCs, NO, cyclic guanosine monophosphate (cGMP), RBC-NOS Serine1177 phosphorylation level and eNOS/Calmodulin (CaM)/Heat Shock Protein-90 (HSP90) interaction levels were higher in ESRD-RBCs, indicating increased enzyme activation. Conversely, following RBCs stimulation with insulin or ionomycin, NO and cGMP levels were significantly lower in ESRD- than in C-RBCs, suggesting that uremia might reduce the RBC-NOS response to further stimuli. Additionally, the activity of multidrug-resistance-associated protein-4 (MRP4; cGMP-membrane transporter) was significantly lower in ESRD-RBCs, suggesting a possible compromised efflux of cGMP across the ESRD-RBCs membrane. This study for the first time showed highest basal RBC-NOS activation in ESRD-RBCs, possibly to reduce the negative impact of decreased NOS expression. It is further conceivable that high NO production only partially affects cell function of ESRD-RBCs maybe because in vivo they are unable to respond to physiologic stimuli, such as calcium and/or insulin.

  3. TIME MANAGEMENT FOR ACCOUNTANTS

    Directory of Open Access Journals (Sweden)

    Cristina Elena BIGIOI

    2016-06-01

    Full Text Available Time is money. Every accountant knows that. In our country, the taxes are changing frequently. The accountants have to update their fiscal knowledge. The purpose of the article is to find how the accountants manage their time, taking into consideration the number of fiscal declarations and the fiscal changes. In this article we present some ways to improve time management for accountants.

  4. Galileo Timing Applications

    Science.gov (United States)

    2007-11-01

    Time Interval (PTTI) Meeting Intranet S Internet NetRecord NetRecord NetRecord Figure 11. NetRecorder and Trusted...Summary of application domains for the use of time in cryptography. B2G B2B B2C Applications Military waypoints, judicial reports, construction...document in different languages uses contradicting terms like “UTC,” “GMT,” and world time to refer to exactly the same thing • Individual countries

  5. Optimal time discrimination

    OpenAIRE

    Coşkun, Filiz; Sayalı, Zeynep Ceyda; Gürbüz, Emine; Balcı, Fuat

    2015-01-01

    Optimal Time Discrimination Journal: Quarterly Journal of Experimental Psychology Manuscript ID: QJE-STD 14-039.R1 Manuscript Type: Standard Article Date Submitted by the Author: n/a Complete List of Authors: Çoskun, Filiz; Koç University, Psychology Sayalı Ungerer, Zeynep; Koç University, Psychology Gürbüz, Emine; Koç University, Psychology Balcı, Fuat; Koç University, Psychology Keywords: Decision making, Interval Timing, Optimality, Response Times, Temporal ...

  6. Utilizing Fractal Time

    Science.gov (United States)

    Marks-Tarlow, Terry

    Linear concepts of time plus the modern capacity to track history emerged out of circular conceptions characteristic of ancient and traditional cultures. A fractal concept of time lies implicitly within the analog clock, where each moment is treated as unique. With fractal geometry the best descriptor of nature, qualities of self-similarity and scale invariance easily model her endless variety and recursive patterning, both in time and across space. To better manage temporal aspects of our lives, a fractal concept of time is non-reductive, based more on the fullness of being than on fragments of doing. By using a fractal concept of time, each activity or dimension of life is multiply and vertically nested. Each nested cycle remains simultaneously present, operating according to intrinsic dynamics and time scales. By adding the vertical axis of simultaneity to the horizontal axis of length, time is already full and never needs to be filled. To attend to time's vertical dimension is to tap into the imaginary potential for infinite depth. To switch from linear to fractal time allows us to relax into each moment while keeping in mind the whole.

  7. Intrinsic Time Quantum Geometrodynamics

    CERN Document Server

    Ita, Eyo Eyo; Yu, Hoi-Lai

    2015-01-01

    Quantum Geometrodynamics with intrinsic time development and momentric variables is presented. An underlying SU(3) group structure at each spatial point regulates the theory. The intrinsic time behavior of the theory is analyzed, together with its ground state and primordial quantum fluctuations. Cotton-York potential dominates at early times when the universe was small; the ground state naturally resolves Penrose's Weyl Curvature Hypothesis, and thermodynamic and gravitational `arrows of time' point in the same direction. Ricci scalar potential corresponding to Einstein's General Relativity emerges as a zero-point energy contribution. A new set of fundamental canonical commutation relations without Planck's constant emerges from the unification of Gravitation and Quantum Mechanics.

  8. Motor timing under microgravity.

    Science.gov (United States)

    Semjen, A; Leone, G; Lipshits, M

    1998-01-01

    Five participants were tested on their ability to produce accurate and regular inter-response intervals in the 350 to 530 ms time range. Three of them were members of the French-Russian CASSIOPEE 96 spaceflight mission, and the other two were control subjects tested on the ground. During spaceflight, the target inter-response intervals were increasingly undershot and the timing became more variable (less regular). The increase in the timing variability was mostly attributable to the internal timekeeping processes rather than those involved in motor execution. The results are discussed with reference to the physiological mechanisms possibly underlying the timing of fast serial movements.

  9. Body, time and transfiguration

    Directory of Open Access Journals (Sweden)

    Jesús Alberto Cabañas Osorio

    2009-11-01

    Full Text Available Following exposure has as premise; make an x-ray of the time within the human body. An analysis of ways of time and pace inhabit and structured the body as subject and creative act processes that we as a synthesis of organic, cosmic and synthetic elements. Thus the trial proposed highlight corporeity as a time in relation to the imaginary and their creative powers that interaction and change, appear in be like Transfiguration of natural to the figurative principle structure. Here the title of exposure: time, body and transfiguration

  10. The use of continuous ambulatory peritoneal dialysis for patients with end-stage renal disease and pre-existing advanced liver disease

    Directory of Open Access Journals (Sweden)

    Anupma Kaul

    2013-01-01

    Full Text Available End-stage renal disease (ESRD associated with pre-existing advanced liver disease (ALD has increased the risk of morbidity and mortality. The aim of this study is to assess the outcome following the use of continuous ambulatory peritoneal dialysis (CAPD in ESRD patients with ALD. A retrospective case-controlled study was performed on 16 patients with ALD and ESRD (ESRD-ALD and 27 control patients with ESRD but without liver disease (ESRD; both groups were started on CAPD during the same period. No major complications were observed in either group in the immediate post-surgical period and, after an average break in period of 11.3 days, the cases and controls were started on regular CAPD. The average duration of follow-up was 8 ± 2.3 months in the ESRD-ALD group compared with 20 ± 1.3 months in the ESRD group. The overall peritonitis rates were 1.26/treatment year in the ESRD-ALD group and 0.63 in the ESRD group. The 6- and 12-month survivals among ESRD-ALD patients were 63.75% and 38.75%, respectively. Patients with ESRD-ALD had significantly lower baseline serum protein and albumin levels at the time of initiation of CAPD. On follow-up, the hemoglobin levels improved in both the groups along with an improvement in the serum protein and albumin levels. Fourteen of the 16 ESRD-ALD patients died at the end of the 3-year follow-up period; deaths were due to terminal liver failure in nine patients and peritonitis in five patients. Patients who died in the ESRD-ALD group had lower serum albumin, lower body mass index (BMI (median BMI 18.2 vs. 25.6 and higher grades of liver disease [child Pugh grade B (8, grade C (6 vs. grade B (2] at initiation of CAPD. Our study suggests that CAPD is a safe modality in patients with ESRD-ALD and that it does not carry any major risk for bleeding tendencies, technique failure or worsening of nutritional status. Low serum albumin, lower BMI and higher grade of liver disease at initiation are associated with higher

  11. Time Functions as Utilities

    Science.gov (United States)

    Minguzzi, E.

    2010-09-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K + relation (Seifert’s relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg’s and Levin’s theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K + (or Seifert) relation which indeed turns out to be the intersection of the time or temporal orderings. This result tells us in which circumstances it is possible to recover the chronological or causal relation starting from the set of time or temporal functions allowed by the spacetime. Moreover, it is proved that a chronological spacetime in which the closure of the causal relation is transitive (for instance a reflective spacetime) admits a semi-time function. Along the way a new proof avoiding smoothing techniques is given that the existence of a time function implies stable causality, and a new short proof of the equivalence between K-causality and stable causality is given which takes advantage of Levin’s theorem and smoothing techniques.

  12. TIME WILL TELL

    DEFF Research Database (Denmark)

    Dalsgård, Anne Line

    2016-01-01

    in the neighbourhood, as credit credit cards are locked in a punctuated time, where dates are crucial. Using an episode that I happened to be part of as point of departure, I argue that decepção is the estrangement experienced, when a moment of trust is thrown back upon you, distorted by the process of time....

  13. Psychoanalysis and time.

    Science.gov (United States)

    Arlow, J A

    1986-01-01

    Psychoanalysis is fundamentally related to time because it is an effort to understand how disturbances in the present are determined by events in the past. Technically, we know that the patient who is reporting immediate perceptions is not aware of the passage of time, but he becomes self-conscious as undesirable elements threaten to appear in his associations. Time is not sensed by direct awareness, nor is it an agent of action or events. Various functions of the ego influence how time is experienced consciously, leading to phenomena such as déjà vu, a sensation of timelessness, misjudgment of time duration, the experience of premonition. Psychoanalysis more than any other discipline sheds light on the coexistence of past, present, and future, as influenced by unconscious fantasy thinking. The analyst's understanding of the patient's associations is guided by temporal factors such as context and contiguity, succession of similar or opposite elements. Basically, the self is a time-bound concept; identity implies that a self is the same entity at different points in time. There is a deep-seated rebellion against the tyranny of time, beginning with need frustration in the infant and culminating in the knowledge that man is destined to lose the struggle against death.

  14. Real Time Systems

    DEFF Research Database (Denmark)

    Christensen, Knud Smed

    2000-01-01

    Describes fundamentals of parallel programming and a kernel for that. Describes methods for modelling and checking parallel problems. Real time problems.......Describes fundamentals of parallel programming and a kernel for that. Describes methods for modelling and checking parallel problems. Real time problems....

  15. Trauma resuscitation time.

    NARCIS (Netherlands)

    Olden, G.D.J. van; Vugt, A.B. van; Biert, J.; Goris, R.J.A.

    2003-01-01

    Documenting the timing and organisation of trauma resuscitation can be utilised to assess performance standards, and to ensure a high quality of trauma resuscitation procedures. Since there is no European literature available on trauma resuscitation time (TRT) in the emergency room, the aim of this

  16. Time management and procrastination

    NARCIS (Netherlands)

    van Eerde, W.; Mumford, M.D.; Frese, M.

    2015-01-01

    This chapter combines the topics time management and procrastination. Time management is an overarching term derived from popular notions on how to be effective at work. Procrastination has been mainly researched from a personality perspective, addressing the emotional and psychological issues of th

  17. Trauma resuscitation time.

    NARCIS (Netherlands)

    Olden, G.D.J. van; Vugt, A.B. van; Biert, J.; Goris, R.J.A.

    2003-01-01

    Documenting the timing and organisation of trauma resuscitation can be utilised to assess performance standards, and to ensure a high quality of trauma resuscitation procedures. Since there is no European literature available on trauma resuscitation time (TRT) in the emergency room, the aim of this

  18. Effective Time Management

    OpenAIRE

    Wieprzycka, Agnieszka

    2013-01-01

    This paper presents the importance of time management, focusing on individuals. In subsequent parts of the paper, some of the most common obstacles of time management and ways of overcoming them are characterized. In the final part of the paper the emphasis is put on procrastination. Summing up, some of the author’s reflections are presented in this paper.

  19. Unit 6 Nap Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: After a busy morning,it is time for a little rest."It’s nap time. Take off your shoes,"says Miss Grant. She helps everyone get their sleeping bags and makes sure that everyone has put their shoes outside Before everyone falls asleep they ask the teacher," Read us a story, please."

  20. Aspect and Reference time

    NARCIS (Netherlands)

    Borik, O.

    2002-01-01

    This thesis provides a theory of aspect in Russian based on the notion of Reference time. The main claim advocated in this study is that there are two types of aspect, predicational/telicity aspect and perspective or Reference time aspect. It is argued that these two types should be carefully distin

  1. Real Time Systems

    DEFF Research Database (Denmark)

    Christensen, Knud Smed

    2000-01-01

    Describes fundamentals of parallel programming and a kernel for that. Describes methods for modelling and checking parallel problems. Real time problems.......Describes fundamentals of parallel programming and a kernel for that. Describes methods for modelling and checking parallel problems. Real time problems....

  2. Peircean diagrams of time

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2011-01-01

    Some very good arguments can be given in favor of the Augustinean wisdom, according to which it is impossible to provide a satisfactory definition of the concept of time. However, even in the absence of a proper definition, it is possible to deal with conceptual problems regarding time. It can be...

  3. Real-Time Evaluations

    Directory of Open Access Journals (Sweden)

    UNHCR

    2002-07-01

    Full Text Available A real-time evaluation (RTE is a timely, rapid andinteractive review of a fast evolving humanitarianoperation undertaken at an early phase. Its broadobjectives are to gauge the effectiveness and impactof a given UNHCR response and to ensure that itsfindings are used as an immediate catalyst fororganisational and operational change.

  4. Optimising Lecture Time

    DEFF Research Database (Denmark)

    Holst-Christensen, Bo

    the students problems from the educator to the students. By using techniques that put more weight on student participation, cooperation and preparation, I have been able to cut significantly down on the time used for lecturing, allowing more time for student work and reflection. As an example by getting...

  5. Time and Teaching

    Science.gov (United States)

    Zielinski, Theresa Julia; Brooks, David W.; Crippen, Kent J.; March, Joe L.

    2001-06-01

    Time management is an important issue for teachers and students. This article discusses teachers' use of time from the perspective of curriculum and instruction. Average high school students spend fewer than 5 hours per week in outside-of-class study; average college students spend about 20 hours. Procrastination, often viewed in a negative light by teachers, usually pays off so well for college students that seniors become better at it than freshmen. Three suggestions for designing instruction are: test early and often; do not waste the best students' time in an effort to improve overall performance; and use engaging activities that motivate students to give of their time. The impact of computers on curricula is a double-edged sword. Time must be devoted to teaching the use of applications, but the programs reduce busywork. Will this turn out to be a simple tradeoff, or will the programs make us much more efficient so that less time is required? Will computer programs ultimately lead to an expanded criterion for expertise, thus demanding even more time to become an expert? These issues are described and suggestions for controlling time during instruction are provided.

  6. Time Series Momentum

    DEFF Research Database (Denmark)

    Moskowitz, Tobias J.; Ooi, Yao Hua; Heje Pedersen, Lasse

    2012-01-01

    under-reaction and delayed over-reaction. A diversified portfolio of time series momentum strategies across all asset classes delivers substantial abnormal returns with little exposure to standard asset pricing factors and performs best during extreme markets. Examining the trading activities...... of speculators and hedgers, we find that speculators profit from time series momentum at the expense of hedgers....

  7. Time - A Traveler's Guide

    Science.gov (United States)

    Pickover, Clifford A.

    1999-09-01

    "Bucky Fuller thought big," Wired magazine recently noted, "Arthur C. Clarke thinks big, but Cliff Pickover outdoes them both." In his newest book, Cliff Pickover outdoes even himself, probing a mystery that has baffled mystics, philosophers, and scientists throughout history--What is the nature of time?In Time: A Traveler's Guide , Pickover takes readers to the forefront of science as he illuminates the most mysterious phenomenon in the universe--time itself. Is time travel possible? Is time real? Does it flow in one direction only? Does it have a beginning and an end? What is eternity? Pickover's book offers a stimulating blend of Chopin, philosophy, Einstein, and modern physics, spiced with diverting side-trips to such topics as the history of clocks, the nature of free will, and the reason gold glitters. Numerous diagrams ensure readers will have no trouble following along.By the time we finish this book, we understand a wide variety of scientific concepts pertaining to time. And most important, we will understand that time travel is, indeed, possible.

  8. The metrology of time.

    Science.gov (United States)

    Arias, Elisa Felicitas

    2005-09-15

    Measuring time is a continuous activity, an international and restless enterprise hidden in time laboratories spread all over the planet. The Bureau International des Poids et Mesures is charged with coordinating activities for international timekeeping and it makes use of the world's capacity to produce a remarkably stable and accurate reference time-scale. Commercial atomic clocks beating the second in national laboratories can reach a stability of one part in 10(14) over a 5 day averaging time, compelling us to research the most highly performing methods of remote clock comparison. The unit of the international time-scale is the second of the International System of Units, realized with an uncertainty of the order 10(-15) by caesium fountains. Physicists in a few time laboratories are making efforts to gain one order of magnitude in the uncertainty of the realization of the second, and more refined techniques of time and frequency transfer are in development to accompany this progress. Femtosecond comb technology will most probably contribute in the near future to enhance the definition of the second with the incorporation of optical clocks. We will explain the evolution of the measuring of time, current state-of-the-art measures and future challenges.

  9. Time management and procrastination

    NARCIS (Netherlands)

    van Eerde, W.; Mumford, M.D.; Frese, M.

    2015-01-01

    This chapter combines the topics time management and procrastination. Time management is an overarching term derived from popular notions on how to be effective at work. Procrastination has been mainly researched from a personality perspective, addressing the emotional and psychological issues of

  10. Periodic Time Series Models

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    2004-01-01

    textabstractThis book considers periodic time series models for seasonal data, characterized by parameters that differ across the seasons, and focuses on their usefulness for out-of-sample forecasting. Providing an up-to-date survey of the recent developments in periodic time series, the book

  11. Time Here, Time There, Time Everywhere: Teaching Young Children Time through Daily Routine

    Science.gov (United States)

    Lee, Joohi; Lee, Joo Ok; Fox, Jill

    2009-01-01

    According to Piaget, 5- or 6-year-old children gradually acquire the concept of time based on events (Piaget, 1969). In his experiment of investigating children's time concepts, Piaget found that children of these ages were able to place pictures based on sequential events with some errors; the younger children made more errors. The National…

  12. Floquet Time Crystals.

    Science.gov (United States)

    Else, Dominic V; Bauer, Bela; Nayak, Chetan

    2016-08-26

    We define what it means for time translation symmetry to be spontaneously broken in a quantum system and show with analytical arguments and numerical simulations that this occurs in a large class of many-body-localized driven systems with discrete time-translation symmetry.

  13. Pulsar Timing Techniques

    CERN Document Server

    Lommen, Andrea N

    2013-01-01

    We describe the procedure, nuances, issues, and choices involved in creating times-of-arrival (TOAs), residuals and error bars from a set of radio pulsar timing data. We discuss the issue of mis-matched templates, the problem that wide- bandwidth backends introduce, possible solutions to that problem, and correcting for offsets introduced by various observing systems.

  14. Time in the Making

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Katrine Remmen

    Rafei, Julie Ault and the cabaret Metro Al Madina in Beirut, Time in the Making investigates how to shift Sedgwick’s concept of the reparative practice from a hermeneutic reading practice to artistic practices and an image in itself. Time in the Making articulates an understanding of the reparative...

  15. Time for Ethnography

    Science.gov (United States)

    Jeffrey, Bob; Troman, Geoff

    2004-01-01

    Ethnography derives from traditional anthropology, where time in the field is needed to discern both the depth and complexity of social structures and relations. Funding bodies, seeking quick completion, might see ethnographies as unlikely to satisfy 'value for money' criteria, in spite of the rewards to be gained from time-consuming 'thick…

  16. Electrodynamics and Time Orientability

    Science.gov (United States)

    Hadley, Mark J.

    2017-06-01

    On spacetimes that are not time orientable we construct a U(1) bundle to measure the twisting of the time axis. This single assumption, and simple construction, gives rise to Maxwell's equations of electromagnetism, the Lorentz force law and the Einstein-Maxwell equations for electromagnetism coupled to General relativity. The derivations follow the Kaluza Klein theory, but with the constraints required for connections on a U(1) bundle rather than five spacetime dimensions. The non time orientability is seen to justify and constrain Kaluza Klein theories exactly as required to unify gravitation with electromagnetism. Unlike any other schemes, apparent net electric charges arise naturally because the direction of the electric field reverses along a time reversing path. The boundary of a time reversing region can therefore have a net electric flux and appear exactly as a region containing an electric charge. The treatment is purely classical, but motivated by links between acausal structures and quantum theory.

  17. Time Domain Induced Polarization

    DEFF Research Database (Denmark)

    Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

    2012-01-01

    Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use...... of time-domaininduced polarization for wider purposes. For these reasons, a new forward code and inversion algorithm have been developed using the full-time decay of the induced polarization response, together with an accurate description of the transmitter waveform and of the receiver transfer function......%. Furthermore, the presence of low-pass filters in time-domain-induced polarization instruments affects the early times of the acquired decays (typically up to 100 ms) and has to be modeled in the forward response to avoid significant loss of resolution. The developed forward code has been implemented in a 1D...

  18. Real-time Cosmology

    CERN Document Server

    Quercellini, Claudia; Balbi, Amedeo; Cabella, Paolo; Quartin, Miguel

    2010-01-01

    In recent years the possibility of measuring the temporal change of radial and transverse position of sources in the sky in real time have become conceivable thanks to the thoroughly improved technique applied to new astrometric and spectroscopic experiments, leading to the research domain we call Real-time cosmology. We review for the first time great part of the work done in this field, analysing both the theoretical framework and some endeavor to foresee the observational strategies and their capability to constrain models. We firstly focus on real time measurements of the overall redshift drift and angular separation shift in distant source, able to trace background cosmic expansion and large scale anisotropy, respectively. We then examine the possibility of employing the same kind of observations to probe peculiar and proper acceleration in clustered systems and therefore the gravitational potential. The last two sections are devoted to the short time future change of the cosmic microwave background, as ...

  19. Time, money, and morality.

    Science.gov (United States)

    Gino, Francesca; Mogilner, Cassie

    2014-02-01

    Money, a resource that absorbs much daily attention, seems to be involved in much unethical behavior, which suggests that money itself may corrupt. This research examined a way to offset such potentially deleterious effects-by focusing on time, a resource that tends to receive less attention than money but is equally ubiquitous in daily life. Across four experiments, we examined whether shifting focus onto time can salvage individuals' ethicality. We found that implicitly activating the construct of time, rather than money, leads individuals to behave more ethically by cheating less. We further found that priming time reduces cheating by making people reflect on who they are. Implications for the use of time primes in discouraging dishonesty are discussed.

  20. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  1. The Production of Time

    CERN Document Server

    Helfer, Adam

    2008-01-01

    I suggest that measurement in quantum theory should be regarded as a sense of time (of things happening), which is as important as the conventional relativistic notion of time. A key question -- of basic physical interest whether one accepts the arguments here or not -- is, What physical criteria determine when a measurement takes place? I suggest a way in which the answer to this may be bound up with the resolution of some pathologies associated with the stress-energy operator, and may at the same time determine the cosmic flow of time. The problem of reconciling the quantum sense of time (measurement) and the conventional relativistic one gives some indication that the the correct "quantization" of gravity is essentially different from that of other fields.

  2. Reducing client waiting time.

    Science.gov (United States)

    1992-01-01

    This first issues of Family Planning (FP) Manager focuses on how to analyze client waiting time and reduce long waits easily and inexpensively. Client flow analysis can be used by managers and staff to identify organizational factors affecting waiting time. Symptoms of long waiting times are overcrowded waiting rooms, clients not returning for services, staff complaints about rushing and waiting, and hurried counseling sessions. Client satisfaction is very important in order to retain FP users. Simple procedures such as routing return visits differently can make a difference in program effectiveness. Assessment of the number of first visits, the number of revisits, and types of methods and services that the clinic provides is a first step. Client flow analysis involves assigning a number to each client on registration, attaching the client flow form to the medical chart, entering the FP method and type of visit, asking staff to note the time at each station, and summarizing data in a master chart. The staff should be involved in plotting data for each client to show waiting versus staff contact time through the use of color coding for each type of staff contact. Bottlenecks become very visible when charted. The amount of time spent at each station can be measured, and gaps in client's contact with staff can be identified. An accurate measure of total waiting time can be obtained. A quick assessment can be made by recording arrival and departure times for each client in one morning or afternoon of a peak day. The procedure is to count the number of clients waiting at 15-minute intervals. The process should be repeated every 3-6 months to observe changes. If waiting times appear long, a more thorough assessment is needed on both a peak and a typical day. An example is given of a completed chart and graph of results with sample data. Managers need to set goals for client flow, streamline client routes, and utilize waiting time wisely by providing educational talks

  3. Time functions as utilities

    CERN Document Server

    Minguzzi, E

    2009-01-01

    Every time function on spacetime gives a (continuous) total preordering of the spacetime events which respects the notion of causal precedence. The problem of the existence of a (semi-)time function on spacetime and the problem of recovering the causal structure starting from the set of time functions are studied. It is pointed out that these problems have an analog in the field of microeconomics known as utility theory. In a chronological spacetime the semi-time functions correspond to the utilities for the chronological relation, while in a K-causal (stably causal) spacetime the time functions correspond to the utilities for the K^+ relation (Seifert's relation). By exploiting this analogy, we are able to import some mathematical results, most notably Peleg's and Levin's theorems, to the spacetime framework. As a consequence, we prove that a K-causal (i.e. stably causal) spacetime admits a time function and that the time or temporal functions can be used to recover the K^+ (or Seifert) relation which indeed...

  4. Construction time of PWRs

    Energy Technology Data Exchange (ETDEWEB)

    Carajilescov, Pedro; Moreira, Joao M.L., E-mail: pedro.carajilescov@ufabc.edu.b, E-mail: joao.moreira@ufabc.edu.b [Universidade Federal do ABC (UFABC), Santo Andre, SP (Brazil). Center of Engineering, Modeling and Applied Social Sciences

    2011-07-01

    The cost of electricity generated by nuclear power is greatly affected by the capital cost, which is dependent on the construction time of the plant. This work analyses the construction time of PWRs in several countries with different market structure and licensing experience. Countries which succeeded to establish a more collaborative environment among utilities, constructors, regulators, and energy planners through effective partnerships were able to build PWRs in shorter times. The construction time in Germany, France and Russia was around 80 months and in Japan, about 60 months. The envelope of 95% of the cases includes a range between 50 and 250 months of construction time. The evaluations show that construction time of PWRs has been longer for countries that did not hold the technology to build their own reactors, and depended on contracts with foreign suppliers. The nominal power of the reactors was considered a measure of plant size, technology complexity and standardization. Countries with standardized reactor designs (France, Japan and Russia) were able to build plants in shorter times. (author)

  5. Simulating space and time

    CERN Document Server

    Whitworth, B

    2010-01-01

    This chapter asks if a virtual space-time could appear to those within it as our space-time does to us. A processing grid network is proposed to underlie not just matter and energy, but also space and time. The suggested "screen" for our familiar three dimensional world is a hyper-sphere surface simulated by a grid network. Light and matter then travel, or are transmitted, in the "directions" of the grid architecture. The processing sequences of grid nodes create time, as the static states of movies run together emulate events. Yet here what exists are not the static states, but the dynamic processing between them. Quantum collapse is the irreversible event that gives time its direction. In this model, empty space is null processing, directions are node links, time is processing cycles, light is a processing wave, objects are wave tangles and energy is the processing transfer rate. It describes a world where empty space is not empty, space warps, time dilates, and everything began when this virtual universe "...

  6. Time Asymmetric Quantum Mechanics

    Directory of Open Access Journals (Sweden)

    Arno R. Bohm

    2011-09-01

    Full Text Available The meaning of time asymmetry in quantum physics is discussed. On the basis of a mathematical theorem, the Stone-von Neumann theorem, the solutions of the dynamical equations, the Schrödinger equation (1 for states or the Heisenberg equation (6a for observables are given by a unitary group. Dirac kets require the concept of a RHS (rigged Hilbert space of Schwartz functions; for this kind of RHS a mathematical theorem also leads to time symmetric group evolution. Scattering theory suggests to distinguish mathematically between states (defined by a preparation apparatus and observables (defined by a registration apparatus (detector. If one requires that scattering resonances of width Γ and exponentially decaying states of lifetime τ=h/Γ should be the same physical entities (for which there is sufficient evidence one is led to a pair of RHS's of Hardy functions and connected with it, to a semigroup time evolution t_0≤t<∞, with the puzzling result that there is a quantum mechanical beginning of time, just like the big bang time for the universe, when it was a quantum system. The decay of quasi-stable particles is used to illustrate this quantum mechanical time asymmetry. From the analysis of these processes, we show that the properties of rigged Hilbert spaces of Hardy functions are suitable for a formulation of time asymmetry in quantum mechanics.

  7. Fragments of Time

    DEFF Research Database (Denmark)

    Christiansen, Steen Ledet

    Time travel films necessarily fragment linear narratives, as scenes are revisited with differences from the first time we saw it. Popular films such as Back to the Future mine comedy from these visitations, but there are many different approaches. One extreme is Chris Marker's La Jetée - a film...... made almost completely of still images, recounting the end of the world. These stills can be viewed as fragments that have survived the end of the world and now provide the only access to the events that occured. Shane Carruth's Primer has a different approach to time travel, the narrative diegesis...

  8. Environment Induced Time Arrow

    CERN Document Server

    Polonyi, Janos

    2012-01-01

    The spread of the time arrows from the environment to an observed subsystem is followed within a harmonic model. A similarity is pointed out between irreversibility and a phase with spontaneously broken symmetry. The causal structure of interaction might be lost in the irreversible case, as well. The Closed Time Path formalism is developed for classical systems and shown to handle the time arrow problem in a clear and flexible manner. The quantum case is considered, as well, and the common origin of irreversibility and decoherence is pointed out.

  9. Lead Time Study,

    Science.gov (United States)

    1982-05-01

    AD-A128 318 LEAD TIME STUDY (U) ARMY ARMAMENT RESEARCH AND DEVELOPMENT CDMMAND DOVER NJ SYSTEMS ANALYSIS DIV dI-T~~ CHU MAY 82 ARRAA 82- 3/ /l N...EhhEEE--E 1111.0 U 1 - I 1120 1.25I1,,-. 11.6 MICROCOPY RESOLUTION TESI CHARI NATIONAL BUREAU 01 STANDARDt 19t,3 A co LEAD TIME STUDY c*A JULIE CHU MAY...188 D I.-f . . .... .. - r - .. " ’- -~ L - - _ _ __ ARRAA 82-3 LEAD TIME STUDY Prepared by:_ JL CHU Reviewed by:Li t’ ( LAWRENCE J. QWUNI Chief, Sys

  10. Neurotransmitters affecting time perception

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND:It has been demonstrated that dopamine and acetylcholine are the main neurotransmitters that affect time perception,which is also affected by other neurotransmitters.OBJECTIVE:To summarize how the neurotransmitter affect the time perception,and put forward the perspectives for further study on time perception.RETRIEVE STRATEGY:An online search for related literatures published in English was conducted in Elsevier SDOL(ScienceDirect Online)database from May 1990 to March 2007 using key words of "timing neurotransmitter".Totally 69 literatures were collected,and they were primarily checked.Inclusive criteria:Reviews and experimental studies;correlative studies of timing neurotransmitter.Exclusive criteria:Repeated studies.LITERATURE EVALUATION:The literatures were mainly sourced from Cognitive Brain Research and Neuroscience,and they were analyzed according to the inclusive criteria.Nineteen of them were involved,and all were experimental studies and reviews.DATA SYNTHESIS:The studies on time perception are developed mainly concentrating on dopamine and acetylcholine.Dopamine D2 receptors mainly affect the speed of internal clock.Dopamine receptors play an important role in both timing excitation and inhibition,which suggests the bi-directional regulation of dopamine.Injection of dopamine agonist can affect the attention to timing information.Injection of BW813U(antagonist of acetylcholine) can induce memory disorder,which indicates the effect of acetylcholine on timing memory,and further study shows that it is the effect of acetylcholine in precentral medial area.In a word,the study on the neurotransmitters affecting time perception is still at the primary stage.CONCLUSION:Dopamine and acetylcholine are the neurotransmitters known to be related to time perception.Dopamine in the basal ganglia is related to internal-clock in the range of seconds and minutes;Acetylcholine in prefrontal cortex is related to the mechanisms of temporal memory and attention

  11. Just in Time Assurance

    Science.gov (United States)

    2010-04-01

    Just in Time Assurance Ji Al F PhD U i it f Id hm ves- oss, , n vers y o a o Director Center for Secure and Dependable Computing W. Mark Vanfleet...COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Just in Time Assurance 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...discusses how practical and affordable recertification can become the norm instead of the rare exception 2 What Does Just in Time Mean? Manufacturing

  12. Paradoxes of time travel

    CERN Document Server

    Krasnikov, S V

    1997-01-01

    Paradoxes that can supposedly occur if a time machine is created are discussed. It is shown that the existence of trajectories of ``multiplicity zero'' (i.e. trajectories that describe a ball hitting its younger self so that the latter cannot fall into the time machine) is not paradoxical by itself. This {\\em apparent paradox} can be resolved (at least sometimes) without any harm to local physics or to the time machine. Also a simple model is adduced for which the absence of {\\em true} paradoxes caused by self-interaction is proved.

  13. Smartphones and Time Zones

    Science.gov (United States)

    Baird, William; Secrest, Jeffery; Padgett, Clifford; Johnson, Wayne; Hagrelius, Claire

    2016-09-01

    Using the Sun to tell time is an ancient idea, but we can take advantage of modern technology to bring it into the 21st century for students in astronomy, physics, or physical science classes. We have employed smartphones, Google Earth, and 3D printing to find the moment of local noon at two widely separated locations. By reviewing GPS time-stamped photos from each place, we are able to illustrate that local noon is longitude-dependent and therefore explain the need for time zones.

  14. Accelerating time to benefit

    DEFF Research Database (Denmark)

    Svejvig, Per; Geraldi, Joana; Grex, Sara

    Despite the ubiquitous pressure for speed, our approaches to accelerate projects remain constrained to the old-fashioned understanding of the project as a vehicle to deliver products and services, not value. This article explores an attempt to accelerate time to benefit. We describe and deconstruct...... of the time. Although all cases valued speed and speed to benefit, and implemented most practices proposed by the methodology, only three of the five projects were more successful in decreasing time to speed. Based on a multi-case study comparison between these five different projects and their respective...

  15. Real-time shadows

    CERN Document Server

    Eisemann, Elmar; Assarsson, Ulf; Wimmer, Michael

    2011-01-01

    Important elements of games, movies, and other computer-generated content, shadows are crucial for enhancing realism and providing important visual cues. In recent years, there have been notable improvements in visual quality and speed, making high-quality realistic real-time shadows a reachable goal. Real-Time Shadows is a comprehensive guide to the theory and practice of real-time shadow techniques. It covers a large variety of different effects, including hard, soft, volumetric, and semi-transparent shadows.The book explains the basics as well as many advanced aspects related to the domain

  16. Priced Timed Automata

    DEFF Research Database (Denmark)

    Behrmann, Gerd; Larsen, Kim Guldstrand; Rasmussen, Jacob Illum

    2004-01-01

    This contribution reports on the considerable effort made recently towards extending and applying well-established timed automata technology to optimal scheduling and planning problems. The effort of the authors in this direction has to a large extent been carried out as part of the European proj...... projects VHS [22] and AMETIST [17] and are available in the recently released UPPAAL CORA [12], a variant of the real-time verification tool UPPAAL [20,5] specialized for cost-optimal reachability for the extended model of priced timed automata....

  17. Identity/Time

    Directory of Open Access Journals (Sweden)

    Nancy J. Knauer

    2013-09-01

    Full Text Available This paper engages the unspoken fourth dimension of intersectionality—time. Using the construction of lesbian, gay, bisexual, and transgender (LGBT identities as an example, it establishes that identity, as it is lived and experienced, is not only multivalent, but also historically contingent. It then raises a number of points regarding the temporal locality of identity—the influence of time on issues of identity and understanding, its implications for legal interventions, social movement building, and paradigms of progressive change. As the title suggests, the paper asks us to consider the frame of identity over time.

  18. Irreversibility time scale.

    Science.gov (United States)

    Gallavotti, G

    2006-06-01

    Entropy creation rate is introduced for a system interacting with thermostats (i.e., for a system subject to internal conservative forces interacting with "external" thermostats via conservative forces) and a fluctuation theorem for it is proved. As an application, a time scale is introduced, to be interpreted as the time over which irreversibility becomes manifest in a process leading from an initial to a final stationary state of a mechanical system in a general nonequilibrium context. The time scale is evaluated in a few examples, including the classical Joule-Thompson process (gas expansion in a vacuum).

  19. Time, Temporality, Now

    Science.gov (United States)

    Atmanspacher, Harald; Ruhnau, Eva

    The essays in this topical volume inquire into one of the most fundamental issues of philosophy and of the cognitive and natural sciences: the riddle of time. The central feature is the tension between the experience and the conceptualization of time, reflecting an apparently unavoidable antinomy of subjective first-person accounts and objective traditional science. Is time based in the physics of inanimate matter, or does it originate in the operation of our minds? Is it essential for the constitution of reality, or is it just an illusion? Issues of time, temporality, and nowness are paradigms for interdisciplinary work in many contemporary fields of research. The authors of this volume discuss profoundly the mutual relationships and inspiring perspectives. They address a general audience.

  20. Drug Retention Times

    Energy Technology Data Exchange (ETDEWEB)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  1. ALICE Time Projection Chamber

    CERN Multimedia

    Lippmann, C

    2013-01-01

    The Time Projection Chamber (TPC) is the main device in the ALICE 'central barrel' for the tracking and identification (PID) of charged particles. It has to cope with unprecedented densities of charges particles.

  2. Space-time programming

    National Research Council Canada - National Science Library

    Beal, Jacob; Viroli, Mirko

    2015-01-01

    ... in terms of individual devices. This paper aims to provide a unified approach for the investigation and engineering of computations programmed with the aid of space-time abstractions, by bringing together a number of recent results...

  3. Quantum Space-Times

    Science.gov (United States)

    Ashtekar, Abhay

    In general relativity space-time ends at singularities. The big bang is considered as the Beginning and the big crunch, the End. However these conclusions are arrived at by using general relativity in regimes which lie well beyond its physical domain of validity. Examples where detailed analysis is possible show that these singularities are naturally resolved by quantum geometry effects. Quantum space-times can be vastly larger than what Einstein had us believe. These non-trivial space-time extensions enable us to answer of some long standing questions and resolve of some puzzles in fundamental physics. Thus, a century after Minkowski's revolutionary ideas on the nature of space and time, yet another paradigm shift appears to await us in the wings.

  4. Time Asymmetric Quantum Mechanics

    National Research Council Canada - National Science Library

    Arno R Bohm; Manuel Gadella; Piotr Kielanowski

    2011-01-01

      The meaning of time asymmetry in quantum physics is discussed. On the basis of a mathematical theorem, the Stone-von Neumann theorem, the solutions of the dynamical equations, the Schrödinger equation (1...

  5. Chemistry space–time

    Directory of Open Access Journals (Sweden)

    David A. Winkler

    2015-12-01

    Full Text Available As Einstein identified so clearly, space and time are intimately related. We discuss the relationship between time and Euclidean space using spectroscopic and radioastronomical studies of interstellar chemistry as an example. Given the finite speed of light, we are clearly studying chemical reactions occurring tens of thousands of years ago that may elucidate the primordial chemistry of this planet several billion years ago. We also explore space of a different kind – chemical space, with many more dimensions than the four we associate as space–time. Vast chemical spaces also need very efficient (computational methods for their exploration to overcome this ‘curse of dimensionality’. We discuss methods by which the time to explore these new spaces can be very substantially reduced, opening the discovery useful new materials that are the key to our future.

  6. ECAL Timing Performance

    CERN Document Server

    CMS Collaboration

    2014-01-01

    The CMS electromagnetic calorimeter (ECAL) is made of about 75000 scintillating lead tungstate crystals arranged in a barrel and two endcaps. The scintillation light is read out by avalanche photodiodes in the barrel and vacuum phototriodes in the endcaps, at which point the scintillation pulse is amplified and sampled at 40 MHz by the on-detector electronics. The fast signal from the crystal scintillation enables energy as well as timing measurements from the data collected in proton-proton collisions with high energy electrons and photons. The stability of the timing measurement required to maintain the energy resolution is on the order of 1ns. The single-channel time resolution of ECAL measured at beam tests for high energy showers is better than 100 ps. The timing resolution achieved with the data collected in proton-proton collisions at the LHC is presented.

  7. How emotions change time

    Directory of Open Access Journals (Sweden)

    Annett eSchirmer

    2011-10-01

    Full Text Available Experimental evidence suggests that emotions can both speed-up and slow-down the internal clock. Speeding-up has been observed for to-be-timed emotional stimuli that have the capacity to sustain attention, whereas slowing-down has been observed for to-be-timed neutral stimuli that are presented in the context of emotional distractors. These effects have been explained by mechanisms that involve changes in bodily arousal, attention or sentience. A review of these mechanisms suggests both merits and difficulties in the explanation of the emotion-timing link. Therefore, a hybrid mechanism involving stimulus-specific sentient representations is proposed as a candidate for mediating emotional influences on time. According to this proposal, emotional events enhance sentient representations, which in turn support temporal estimates. Emotional stimuli with a larger share in ones sentience are then perceived as longer than neutral stimuli with a smaller share.

  8. Geometry of Psychological Time

    CERN Document Server

    Saniga, M

    2003-01-01

    The paper reviews the most illustrative cases of the "peculiar/anomalous" experiences of time (and, to a lesser extent, also space) and discusses a simple algebraic geometrical model accounting for the most pronounced of them.

  9. Irregular Time Dependent Obstacles

    CERN Document Server

    Lindqvist, Peter

    2010-01-01

    We study the obstacle problem for the Evolutionary p-Laplace Equation when the obstacle is discontinuous and without regularity in the time variable. Two quite different procedures yield the same solution.

  10. 'Time off pays off'.

    Science.gov (United States)

    Larson, Laurie

    2014-01-01

    Small hospitals and other health care organizations often have a hard time hiring physis . Some are finding success by offering extended paid leaves for doctors with a passion for working in medically challenged communities at home and abroad.

  11. Drug Retention Times

    Energy Technology Data Exchange (ETDEWEB)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  12. SILENT VOICES OF TIME

    African Journals Online (AJOL)

    NATIONAL MUSEUM OF MILITARY HISTORY. BY DR S MONICKl* .... The figure of the Greek goddess of Nike surmounts the .... and armed might, that contemporary observers became ... dance with the political facts of their times. Wilhelm II ...

  13. Time consistent portfolio management

    CERN Document Server

    Ekeland, Ivar; Pirvu, Traian A

    2010-01-01

    This paper considers the portfolio management problem of optimal investment, consumption and life insurance. We are concerned with time inconsistency of optimal strategies. Natural assumptions, like different discount rates for consumption and life insurance, or a time varying aggregation rate lead to time inconsistency. As a consequence, the optimal strategies are not implementable. We focus on hyperbolic discounting, which has received much attention lately, especially in the area of behavioural finance. Following [10], we consider the resulting problem as a leader-follower game between successive selves, each of whom can commit for an infinitesimally small amount of time. We then define policies as subgame perfect equilibrium strategies. Policies are characterized by an integral equation which is shown to have a solution. Although we work on CRRA preference paradigm, our results can be extended for more general preferences as long as the equations admit solutions. Numerical simulations reveal that for the ...

  14. Multivariate Time Series Search

    Data.gov (United States)

    National Aeronautics and Space Administration — Multivariate Time-Series (MTS) are ubiquitous, and are generated in areas as disparate as sensor recordings in aerospace systems, music and video streams, medical...

  15. Long time series

    DEFF Research Database (Denmark)

    Hisdal, H.; Holmqvist, E.; Hyvärinen, V.;

    Awareness that emission of greenhouse gases will raise the global temperature and change the climate has led to studies trying to identify such changes in long-term climate and hydrologic time series. This report, written by the......Awareness that emission of greenhouse gases will raise the global temperature and change the climate has led to studies trying to identify such changes in long-term climate and hydrologic time series. This report, written by the...

  16. Time Delay Cosmography

    OpenAIRE

    Treu, Tommaso; Marshall, Philip J.

    2016-01-01

    Gravitational time delays, observed in strong lens systems where the variable background source is multiply-imaged by a massive galaxy in the foreground, provide direct measurements of cosmological distance that are very complementary to other cosmographic probes. The success of the technique depends on the availability and size of a suitable sample of lensed quasars or supernovae, precise measurements of the time delays, accurate modeling of the gravitational potential of the main deflector,...

  17. Long time series

    DEFF Research Database (Denmark)

    Hisdal, H.; Holmqvist, E.; Hyvärinen, V.

    Awareness that emission of greenhouse gases will raise the global temperature and change the climate has led to studies trying to identify such changes in long-term climate and hydrologic time series. This report, written by the......Awareness that emission of greenhouse gases will raise the global temperature and change the climate has led to studies trying to identify such changes in long-term climate and hydrologic time series. This report, written by the...

  18. Distance, Borders, and Time

    DEFF Research Database (Denmark)

    Skillicorn, David; Walther, Olivier; Zheng, Quan

    is a combination of the physical geography of the target environment, and the mental and physical cost of following a seemingly random pattern of attacks. Focusing on the distance and time between attacks and taking into consideration the transaction costs that state boundaries impose, we wish to understand what......” of North and West Africa that depicts the permeability to violence. A better understanding of how location, time, and borders condition attacks enables planning, prepositioning, and response....

  19. Time-predictable architectures

    CERN Document Server

    Rochange, Christine; Uhrig , Sascha

    2014-01-01

    Building computers that can be used to design embedded real-time systems is the subject of this title. Real-time embedded software requires increasingly higher performances. The authors therefore consider processors that implement advanced mechanisms such as pipelining, out-of-order execution, branch prediction, cache memories, multi-threading, multicorearchitectures, etc. The authors of this book investigate the timepredictability of such schemes.

  20. Fossils, rocks, and time

    Science.gov (United States)

    Edwards, Lucy E.; Pojeta, John

    1999-01-01

    We study our Earth for many reasons: to find water to drink or oil to run our cars or coal to heat our homes, to know where to expect earthquakes or landslides or floods, and to try to understand our natural surroundings. Earth is constantly changing--nothing on its surface is truly permanent. Rocks that are now on top of a mountain may once have been at the bottom of the sea. Thus, to understand the world we live on, we must add the dimension of time. We must study Earth's history. When we talk about recorded history, time is measured in years, centuries, and tens of centuries. When we talk about Earth history, time is measured in millions and billions of years. Time is an everyday part of our lives. We keep track of time with a marvelous invention, the calendar, which is based on the movements of Earth in space. One spin of Earth on its axis is a day, and one trip around the Sun is a year. The modern calendar is a great achievement, developed over many thousands of years as theory and technology improved. People who study Earth's history also use a type of calendar, called the geologic time scale. It looks very different from the familiar calendar. In some ways, it is more like a book, and the rocks are its pages. Some of the pages are torn or missing, and the pages are not numbered, but geology gives us the tools to help us read this book.

  1. SPECTRAL ECLIPSE TIMING

    Energy Technology Data Exchange (ETDEWEB)

    Dobbs-Dixon, Ian [Department of Physics, NYU Abu Dhabi P.O. Box 129188 Abu Dhabi (United Arab Emirates); Agol, Eric [Department of Astronomy, University of Washington, Seattle WA 98195 (United States); Deming, Drake [NASA Astrobiology Institute Virtual Planet Laboratory (United States)

    2015-12-10

    We utilize multi-dimensional simulations of varying equatorial jet strength to predict wavelength-dependent variations in the eclipse times of gas-giant planets. A displaced hot spot introduces an asymmetry in the secondary eclipse light curve that manifests itself as a measured offset in the timing of the center of eclipse. A multi-wavelength observation of secondary eclipse, one probing the timing of barycentric eclipse at short wavelengths and another probing at longer wavelengths, will reveal the longitudinal displacement of the hot spot and break the degeneracy between this effect and that associated with the asymmetry due to an eccentric orbit. The effect of time offsets was first explored in the IRAC wavebands by Williams et al. Here we improve upon their methodology, extend to a broad range of wavelengths, and demonstrate our technique on a series of multi-dimensional radiative-hydrodynamical simulations of HD 209458b with varying equatorial jet strength and hot-spot displacement. Simulations with the largest hot-spot displacement result in timing offsets of up to 100 s in the infrared. Though we utilize a particular radiative hydrodynamical model to demonstrate this effect, the technique is model independent. This technique should allow a much larger survey of hot-spot displacements with the James Webb Space Telescope than currently accessible with time-intensive phase curves, hopefully shedding light on the physical mechanisms associated with thermal energy advection in irradiated gas giants.

  2. Time travel a history

    CERN Document Server

    Gleick, James

    2016-01-01

    From the acclaimed author of The Information and Chaos, here is a mind-bending exploration of time travel: its subversive origins, its evolution in literature and science, and its influence on our understanding of time itself. The story begins at the turn of the previous century, with the young H. G. Wells writing and rewriting the fantastic tale that became his first book and an international sensation: The Time Machine. It was an era when a host of forces was converging to transmute the human understanding of time, some philosophical and some technological: the electric telegraph, the steam railroad, the discovery of buried civilizations, and the perfection of clocks. James Gleick tracks the evolution of time travel as an idea that becomes part of contemporary culture—from Marcel Proust to Doctor Who, from Jorge Luis Borges to Woody Allen. He investigates the inevitable looping paradoxes and examines the porous boundary between pulp fiction and modern physics. Finally, he delves into a temporal shift that...

  3. The Time of Materiality

    Directory of Open Access Journals (Sweden)

    Estrid Sørensen

    2007-01-01

    Full Text Available While time and space form a classic duality in social science, this article demonstrates a perspective on time, space and materiality as a core trinity. As a prominent figure in contemporary discussions on materiality in the social sciences Science and Technology Studies (STS emphasizes relational approaches. STS however lacks a clear relational definition of materiality and tends instead to focus on the agency of entities, on for instance material agency. The article suggests a relational definition of materiality and notes that this move implies turning the question of the time of materiality into an empirical question. It is argued that relational materiality must be studied spatially, and thus a spatial approach describing patterns of relations is presented. Based on field work in a primary school classroom and computer lab, three materials are analyzed: the blackboard, a bed-loft and an online 3D virtual environment. The empirical descriptions depict three different materialities, and it is shown how time is formed differently in each of them. Time, it is argued, is an emergent and characterizing aspect of materialities as spatial formations. URN: urn:nbn:de:0114-fqs070122

  4. Extending over time

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel; Christensen, Marie Herget

    recorded twice (in the 1980s and again in the 2000s). This allows us to study language change in three ways: in apparent time and in real time as both panel and trend studies. The study is based on a 1,3 M word corpus of spoken Danish, comprising 125 recordings with 84 Co-penhagen speakers, born 1942......-1013. Sankoff, G. (2006). Age: Apparent time and real time. Encyclopedia of Language and Linguistics. K. Brown. Oxford, Elsevier: 110-116. Sankoff, G. (2013). Longitudinal studies. The Oxford handbook of sociolinguistics. R. Bayley, R. Cameron and C. Lucas. Oxford, Oxford University Press: 261-279. Stubbe, M...... that variants with sådan noget, though prevalent across the board, may be stigmatized, since they are produced mainly by young WC males, and exhibit an overall drop in frequency over time. In our paper, we will use GEs in Danish as a case study for evaluating prevailing assumptions about the relationship...

  5. SNS Diagnostics Timing Integration

    CERN Document Server

    Long, Cary D; Murphy, Darryl J; Pogge, James; Purcell, John D; Sundaram, Madhan

    2005-01-01

    The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based running Windows XP Embedded for its OS and LabVIEW as its programming language. Coordinating timing among the various diagnostics instruments with the generation of the beam pulse is a challenging task that we have chosen to divide into three phases. First, timing was derived from VME based systems. In the second phase, described in this paper, timing pulses are generated by an in house designed PCI timing card installed in ten diagnostics PCs. Using fan-out modules, enough triggers were generated for all instruments. This paper describes how the Timing NAD (Network Attached Device) was rapidly developed using our NAD template, LabVIEW's PCI driver wizard, and LabVIEW Channel Access library. The NAD...

  6. SPS New Timing Tests

    CERN Document Server

    Jacquet, D; Jensen, L; Wehrle, U; Verhagen, H; Partinod, P; Semanaz, P; Jonker, M; Lewis, J; Bau, J C; Bouche, J M; CERN. Geneva. AB Department

    2003-01-01

    The SPS master timing generator is foreseen to be replaced in 2004 by a central timing generator called CBCM, which will control the whole accelerator complex. At this occasion a working group has been created to review the actual SPS timing events and how it could fit in with the new MTG. It has been decided that a rationalization and simplification of the events was necessary in order that the events are manageable by the CBCM. At the end of the 2003 run, the cleaned-up events have been tested with the SPS MTG. Then the CBCM has been plugged to generate the same events. The tests and their results are described in this document.

  7. Drug Retention Times

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user. Based on anecdotal evidence, most people “party” during extended time away from the work environment. Therefore, the following scenarios were envisioned: (1) a person uses an illicit drug at a party on Saturday night (infrequent user); (2) a person uses a drug one time on Friday night and once again on Saturday night (infrequent user); and (3) a person uses a drug on Friday night, uses a drug twice on Saturday night, and once again on Sunday (frequent user).

  8. Real-time radiography

    Energy Technology Data Exchange (ETDEWEB)

    Bossi, R.H.; Oien, C.T.

    1981-02-26

    Real-time radiography is used for imaging both dynamic events and static objects. Fluorescent screens play an important role in converting radiation to light, which is then observed directly or intensified and detected. The radiographic parameters for real-time radiography are similar to conventional film radiography with special emphasis on statistics and magnification. Direct-viewing fluoroscopy uses the human eye as a detector of fluorescent screen light or the light from an intensifier. Remote-viewing systems replace the human observer with a television camera. The remote-viewing systems have many advantages over the direct-viewing conditions such as safety, image enhancement, and the capability to produce permanent records. This report reviews real-time imaging system parameters and components.

  9. Agency, time, and causality.

    Science.gov (United States)

    Widlok, Thomas

    2014-01-01

    Cognitive Scientists interested in causal cognition increasingly search for evidence from non-Western Educational Industrial Rich Democratic people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition.

  10. Time for memory

    DEFF Research Database (Denmark)

    Murakami, Kyoko

    2012-01-01

    This article is a continuous dialogue on memory triggered by Brockmeier’s (2010) article. I drift away from the conventionalization of the archive as a spatial metaphor for memory in order to consider the greater possibility of “time” for conceptualizing memory. The concept of time is central...... in terms of autobiographical memory. The second category of time is discussed, drawing on Augustine and Bergson amongst others. Bergson’s notion of duration has been considered as a promising concept for a better understanding of autobiographical memory. Psychological phenomena such as autobiographical...... memory should embrace not only spatial dimension, but also a temporal dimension, in which a constant flow of irreversible time, where multiplicity, momentarily, dynamic stability and becoming and emergence of novelty can be observed....

  11. Time Delay Cosmography

    CERN Document Server

    Treu, Tommaso

    2016-01-01

    Gravitational time delays, observed in strong lens systems where the variable background source is multiply-imaged by a massive galaxy in the foreground, provide direct measurements of cosmological distance that are very complementary to other cosmographic probes. The success of the technique depends on the availability and size of a suitable sample of lensed quasars or supernovae, precise measurements of the time delays, accurate modeling of the gravitational potential of the main deflector, and our ability to characterize the distribution of mass along the line of sight to the source. We review the progress made during the last 15 years, during which the first competitive cosmological inferences with time delays were made, and look ahead to the potential of significantly larger lens samples in the near future.

  12. Time delay cosmography

    Science.gov (United States)

    Treu, Tommaso; Marshall, Philip J.

    2016-07-01

    Gravitational time delays, observed in strong lens systems where the variable background source is multiply imaged by a massive galaxy in the foreground, provide direct measurements of cosmological distance that are very complementary to other cosmographic probes. The success of the technique depends on the availability and size of a suitable sample of lensed quasars or supernovae, precise measurements of the time delays, accurate modeling of the gravitational potential of the main deflector, and our ability to characterize the distribution of mass along the line of sight to the source. We review the progress made during the last 15 years, during which the first competitive cosmological inferences with time delays were made, and look ahead to the potential of significantly larger lens samples in the near future.

  13. Death, time, and psychosis.

    Science.gov (United States)

    Lombardi, Riccardo

    2013-08-01

    Working through the awareness of death and the consciousness of time, it is hypothesized, plays a decisive role in the analytic process and in the mental growth of psychotic analysands, as well as in the integration of the psychotic areas in healthier patients. Clinical material is presented from a psychotic woman treated analytically, four sessions a week, for twelve years. The patient suffered several acute relapses, during which the analytic work was not interrupted. Her fourth psychotic episode in the course of analysis, which involved a delusion about gray men and the theft of time, is explored in particular depth. This phase fostered the patient's recognition of the value of time, together with the acquisition of her own center of psychosensory integration, the basis of an ability to learn from experience.

  14. Time Discretization Techniques

    KAUST Repository

    Gottlieb, S.

    2016-10-12

    The time discretization of hyperbolic partial differential equations is typically the evolution of a system of ordinary differential equations obtained by spatial discretization of the original problem. Methods for this time evolution include multistep, multistage, or multiderivative methods, as well as a combination of these approaches. The time step constraint is mainly a result of the absolute stability requirement, as well as additional conditions that mimic physical properties of the solution, such as positivity or total variation stability. These conditions may be required for stability when the solution develops shocks or sharp gradients. This chapter contains a review of some of the methods historically used for the evolution of hyperbolic PDEs, as well as cutting edge methods that are now commonly used.

  15. Accelerating time to benefit

    DEFF Research Database (Denmark)

    Svejvig, Per; Geraldi, Joana; Grex, Sara

    Despite the ubiquitous pressure for speed, our approaches to accelerate projects remain constrained to the old-fashioned understanding of the project as a vehicle to deliver products and services, not value. This article explores an attempt to accelerate time to benefit. We describe and deconstruct...... the implementation of a large intervention undertaken in five project-based organizations in Denmark – the Project Half Double where the same project methodology has been applied in five projects, each of them in five distinct organizations in Denmark, as a bold attempt to realize double the benefit in half...... of the time. Although all cases valued speed and speed to benefit, and implemented most practices proposed by the methodology, only three of the five projects were more successful in decreasing time to speed. Based on a multi-case study comparison between these five different projects and their respective...

  16. Timing sight and sound.

    Science.gov (United States)

    Arnold, Derek H; Johnston, Alan; Nishida, Shinya

    2005-05-01

    It has been proposed that there is a perceptual compensation for the difference between the speeds of light and sound. We examined this possibility using a range of auditory-visual tasks, in which performance depends on the relative timing of auditory and visual information, and manipulated viewing distance to test for perceptual compensation. We explored auditory-visual integration, cross modal causal attributions, and auditory-visual temporal order judgments. We observed timing shifts with viewing distance following loudspeaker, but not headphone, presentations. We were unable to find reliable evidence of perceptual compensation. Our findings suggest that auditory and visual signals of an event that reach an observer at the same point in time tend to become perceptually bound, even when the sources of those signals could not have occurred together.

  17. Agency, time and causality

    Directory of Open Access Journals (Sweden)

    Thomas eWidlok

    2014-11-01

    Full Text Available Cognitive Scientists interested in causal cognition increasingly search for evidence from non-WEIRD people but find only very few cross-cultural studies that specifically target causal cognition. This article suggests how information about causality can be retrieved from ethnographic monographs, specifically from ethnographies that discuss agency and concepts of time. Many apparent cultural differences with regard to causal cognition dissolve when cultural extensions of agency and personhood to non-humans are taken into account. At the same time considerable variability remains when we include notions of time, linearity and sequence. The article focuses on ethnographic case studies from Africa but provides a more general perspective on the role of ethnography in research on the diversity and universality of causal cognition.

  18. Probing human response times

    Science.gov (United States)

    Johansen, Anders

    2004-07-01

    In a recent preprint (Dialog in e-mail traffic, preprint cond-mat/0304433), the temporal dynamics of an e-mail network has been investigated by Eckmann, Moses and Sergi. Specifically, the time period between an e-mail message and its reply were recorded. It will be shown here that their data agrees quantitatively with the frame work proposed to explain a recent experiment on the response of “internauts” to a news publication (Physica A 296(3-4) (2001) 539) despite differences in communication channels, topics, time-scale and socio-economic characteristics of the two population. This suggest a generalized response time distribution ∼ t-1 for human populations in the absence of deadlines with important implications for psychological and social studies as well the study of dynamical networks.

  19. On Time chez Dummett

    CERN Document Server

    Butterfield, Jeremy

    2014-01-01

    I discuss three connections between Dummett's writings about time and philosophical aspects of physics. The first connection (Section 2) arises from remarks of Dummett's about the different relations of observation to time and to space. The main point is uncontroversial and applies equally to classical and quantum physics. It concerns the fact that perceptual processing is so rapid, compared with the typical time-scale on which macroscopic objects change their observable properties, that it engenders the idea of a 'common now', spread across space. The other two connections are specific to quantum theory, as interpreted along the lines of Everett. So for these two connections, the physics side is controversial, just as the philosophical side is. In Section 3, I connect the subjective uncertainty before an Everettian 'splitting' of the multiverse to Dummett's suggestion, inspired by McTaggart, that a complete, i.e. indexical-free description of a temporal reality is impossible. And in Section 4, I connect Barb...

  20. Relational time in physics

    Energy Technology Data Exchange (ETDEWEB)

    Assis, A.K.T. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)

    2011-07-01

    Full text: Isaac Newton (1642-1727) defended in his book Mathematical Principles of Natural Philosophy, also know as Principia, published in 1687, the utilization of absolute time in physics. According to him 'absolute, true, and mathematical time, of itself, and from its own nature, flows equably without relation to anything external'. Leibniz (1646-1716), on the other hand, was against this concept and proposed relative time to replace it: 'As for my opinion, I have said more than once, that I hold space to be something merely relative, as time is; that I hold it to be an order of coexistence, as time is an order of successions'. Leibniz ideas were accepted and developed by Ernst Mach (1838-1916) in his book The Science of Mechanics, published in 1883. In this work we consider the implementation of relational time, as proposed by Leibniz and Mach, and the consequences this implementation will mean for physics as a whole. We consider some specific examples related to mechanics (Newton's bucket experiment, the flattening of the Earth, Foucault's pendulum experiment) and to electromagnetism (Ampere's force between current carrying wires, an electric charge describing a Larmor radius due to a nearby large magnet, two charges orbiting around one another). We generalize these ideas considering the principle of physical proportions (PPP), according to which no absolute magnitudes should appear in the laws of physics. We present some laws satisfying this principle and others which do not comply with it. The laws which do not satisfy the PPP should be based upon incomplete theories. We present the consequences of complete theories complying with this fundamental principle of nature. (author)

  1. "TimeFairy" Magic Scores

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ What is time? How is time measured? What are atomic time and coordnated time? Where does standard time come from? Now you can find the answers to such questions at the time website (http:∥www. Time.ac. Cn) set up by the CAS National Time Service Center (NTSC).

  2. Predicting Nonlinear Time Series

    Science.gov (United States)

    1993-12-01

    response becomes R,(k) = f (Y FV,(k)) (2.4) where Wy specifies the weight associated with the output of node i to the input of nodej in the next layer and...interconnections for each of these previous nodes. 18 prr~~~o• wfe :t iam i -- ---- --- --- --- Figure 5: Delay block for ATNN [9] Thus, nodej receives the...computed values, aj(tn), and dj(tn) denotes the desired output of nodej at time in. In this thesis, the weights and time delays update after each input

  3. Time series analysis

    CERN Document Server

    Madsen, Henrik

    2007-01-01

    ""In this book the author gives a detailed account of estimation, identification methodologies for univariate and multivariate stationary time-series models. The interesting aspect of this introductory book is that it contains several real data sets and the author made an effort to explain and motivate the methodology with real data. … this introductory book will be interesting and useful not only to undergraduate students in the UK universities but also to statisticians who are keen to learn time-series techniques and keen to apply them. I have no hesitation in recommending the book.""-Journa

  4. Shackle in Time

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2016-01-01

    GLS Shackle got much and the crucial inspiration from John Maynard Keynes. But that’s not all. He took a number of further consequences of Keynes’ thoughts. This implies for example ideal claims to economists — having to deal with both mechanical time and expectational time. In consequence the idea...... in this paper is to introduce Keynesian Kaleidics as an illustration of how complicated it is to analyze economic contexts. Finally it is discussed how the potential opportunities is to make alternatives to deterministic predictions on the basis of Shackles approach to economic analysis and especially the idea...

  5. Time, Chance, and Reduction

    Science.gov (United States)

    Ernst, Gerhard; Hüttemann, Andreas

    2010-01-01

    List of contributors; 1. Introduction Gerhard Ernst and Andreas Hütteman; Part I. The Arrows of Time: 2. Does a low-entropy constraint prevent us from influencing the past? Mathias Frisch; 3. The part hypothesis meets gravity Craig Callender; 4. Quantum gravity and the arrow of time Claus Kiefer; Part II. Probability and Chance: 5. The natural-range conception of probability Jacob Rosenthal; 6. Probability in Boltzmannian statistical mechanics Roman Frigg; 7. Humean mechanics versus a metaphysics of powers Michael Esfeld; Part III. Reduction: 8. The crystallisation of Clausius's phenomenological thermodynamics C. Ulises Moulines; 9. Reduction and renormalization Robert W. Batterman; 10. Irreversibility in stochastic dynamics Jos Uffink; Index.

  6. Competitive Moves over Time

    DEFF Research Database (Denmark)

    Antero, Michelle; Hedman, Jonas; Henningsson, Stefan

    2014-01-01

    its viability to survive in the marketplace. The study begins with a review of sourcing literature to position the Red Queen theory within the sourcing literature. It subsequently applies the framework to a case study of SAP AG to illustrate how sourcing strategies changed over time in response...... the firm; (c) organizations are reflexive and over time develop competitive hysteresis which allows them to become stronger competitors. In the case of SAP AG, various sourcing arrangements were selected over its 40-year history to respond to technological and market changes....

  7. Applied time series analysis

    CERN Document Server

    Woodward, Wayne A; Elliott, Alan C

    2011-01-01

    ""There is scarcely a standard technique that the reader will find left out … this book is highly recommended for those requiring a ready introduction to applicable methods in time series and serves as a useful resource for pedagogical purposes.""-International Statistical Review (2014), 82""Current time series theory for practice is well summarized in this book.""-Emmanuel Parzen, Texas A&M University""What an extraordinary range of topics covered, all very insightfully. I like [the authors'] innovations very much, such as the AR factor table.""-David Findley, U.S. Census Bureau (retired)""…

  8. Real-Time Shading

    CERN Document Server

    Olano, Marc

    2002-01-01

    This book covers real-time shading systems, their design and how they work. Procedural shading, long valued for off-line rendering and production animation is now possible on interactive graphics hardware. These developments are important for areas such as game development, product design, and scientific visualization, among others. The authors include examples of techniques for achieving common effects efficiently in a real-time shading language ranging from full procedural shading on advanced specialized hardware to limited, yet surprisingly flexible shading on unextended OpenGL, to modern P

  9. Time Will Tell

    DEFF Research Database (Denmark)

    Dalsgård, Anne Line

    2017-01-01

    resources from a speculative future. Decepção [disillusion] may be the experience of the creditor, when a loan is not returned as promised; for the debtor the envisioned future may just not have come about yet. Particularly the frequent loans of credit cards gives rise to emotionally tense situations...... in the neighbourhood, as credit credit cards are locked in a punctuated time, where dates are crucial. Using an episode that I happened to be part of as point of departure, I argue that decepção is the estrangement experienced, when a moment of trust is thrown back upon you, distorted by the process of time....

  10. Science of Time

    Science.gov (United States)

    Vedavyas

    A Multi-disciplinary Research into the Chronologies of Ancient Nations -- like the Vedas of India Rishies, the Chaldeans, Babylonians, Egyptians and the Chinese. Which traces how the "Measurement of Time" -- which began with the observations of sunrise and Sunset, Full-Moons, eclipses, the movement of stars and the Discovery of the Zodiac that starry pathway of sun in his annual Cycle of the 12-Zodiacal months, the Measurement of Time by planetary Cycles the Discovery of Astronomy and Symbolic or Kabalistic Astrology of the Bible's Old Testament; the Epics of Babylonians and 'Cosmic Cycles' of Chaldeans and Egyptians also the Ancient "Four Yugas" or Hindu Vedic Cycles.

  11. Time reversal communication system

    Science.gov (United States)

    Candy, James V.; Meyer, Alan W.

    2008-12-02

    A system of transmitting a signal through a channel medium comprises digitizing the signal, time-reversing the digitized signal, and transmitting the signal through the channel medium. The channel medium may be air, earth, water, tissue, metal, and/or non-metal.

  12. Time and Logic

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2009-01-01

    This paper deals with A.N. Prior's analysis of the concepts of dynamic and static time, i.e. McTaggart's so-called A- and B-concepts. The relations and mutual dependencies between these temporal concepts are investigated, and Prior's response to McTaggart's views is discussed. Futhermore, Prior...

  13. DELPHI time projection chamber

    CERN Multimedia

    1989-01-01

    The time projection chamber is inserted inside the central detector of the DELPHI experiment. Gas is ionised in the chamber as a charged particle passes through, producing an electric signal from which the path of the particle can be found. DELPHI, which ran from 1989 to 2000 on the LEP accelerator, was primarily concerned with particle identification.

  14. Smartphones and Time Zones

    Science.gov (United States)

    Baird, William; Secrest, Jeffery; Padgett, Clifford; Johnson, Wayne; Hagrelius, Claire

    2016-01-01

    Using the Sun to tell time is an ancient idea, but we can take advantage of modern technology to bring it into the 21st century for students in astronomy, physics, or physical science classes. We have employed smartphones, Google Earth, and 3D printing to find the moment of local noon at two widely separated locations. By reviewing GPS…

  15. Falling out of time

    DEFF Research Database (Denmark)

    Oldrup, Helene

    2017-01-01

    on data from a Danish study of mothers and children, aged 5–27, whose father/stepfather was incarcerated. Findings show the significance of a multifaceted understanding of time showing the implications of fathers’ imprisonment for children, suggesting that policy initiatives would be enriched by a focus...

  16. Aid Supplies Over Time

    DEFF Research Database (Denmark)

    Jones, Edward Samuel

    2015-01-01

    of data spanning nearly 50 years, this paper uses panel cointegration techniques to consider these issues. The analysis provides clear evidence for heterogeneity both between donors and over time, bandwagon effects, and a growing influence of security considerations in aid provision. Domestic...

  17. Smartphones and Time Zones

    Science.gov (United States)

    Baird, William; Secrest, Jeffery; Padgett, Clifford; Johnson, Wayne; Hagrelius, Claire

    2016-01-01

    Using the Sun to tell time is an ancient idea, but we can take advantage of modern technology to bring it into the 21st century for students in astronomy, physics, or physical science classes. We have employed smartphones, Google Earth, and 3D printing to find the moment of local noon at two widely separated locations. By reviewing GPS…

  18. Time well spent

    DEFF Research Database (Denmark)

    Fallesen, Peter

    2013-01-01

    Individuals who spent time in foster care as children fare on average worse than non-placed peers in early adult life. Recent research on the effect of foster care placement on early adult life outcomes provides mixed evidence. Some studies suggest negative effects of foster care placement on early...... care on income and labor market participation....

  19. Spirituality in Turbulent Times.

    Science.gov (United States)

    Wheatley, Margaret J.

    2002-01-01

    Discusses the importance of spiritual leadership in turbulent, uncertain times. Describes several spiritual principles--for example, life is cyclical; all life is interconnected. Offers six suggestions for personal health: Start day peacefully, learn to be mindful, slow things down, create own measures, expect surprise, practice gratefulness. (PKP)

  20. Scheduling with Time Lags

    NARCIS (Netherlands)

    X. Zhang (Xiandong)

    2010-01-01

    textabstractScheduling is essential when activities need to be allocated to scarce resources over time. Motivated by the problem of scheduling barges along container terminals in the Port of Rotterdam, this thesis designs and analyzes algorithms for various on-line and off-line scheduling problems

  1. Technology Time Machine 2012

    DEFF Research Database (Denmark)

    Lehner, Wolfgang; Fettweis, Gerhard; Fitzek, Frank

    2013-01-01

    The IEEE Technology Time Machine (TTM) is a unique event for industry leaders, academics, and decision making government officials who direct R&D activities, plan research programs or manage portfolios of research activities. This report covers the main topics of the 2nd Symposium of future...

  2. Budgeting in Hard Times.

    Science.gov (United States)

    Parrino, Frank M.

    2003-01-01

    Interviews with school board members and administrators produced a list of suggestions for balancing a budget in hard times. Among these are changing calendars and schedules to reduce heating and cooling costs; sharing personnel; rescheduling some extracurricular activities; and forming cooperative agreements with other districts. (MLF)

  3. Property Prime Time

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Property developers in China ride the economic high times The billionaires in China now num- ber 106,second only to the United States,according to the Hurun China Rich List compiled by Rupert Hoogewerf,a Shanghai-based independent researcher.Six of the top 10

  4. This Time It's Personal

    Science.gov (United States)

    Demski, Jennifer

    2012-01-01

    Educators have known for some time now that a one-size-fits-all approach to learning does not lead to the level of student engagement and academic success that schools strive to achieve. In their search for a more customized approach to delivering instruction, they've explored project-based learning, addressed different learning styles, and…

  5. Time-Encoded Imagers.

    Energy Technology Data Exchange (ETDEWEB)

    Marleau, Peter; Brubaker, Erik

    2014-11-01

    This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

  6. Keeping time - Performing Place

    DEFF Research Database (Denmark)

    Dvinge, Anne Christine

    2012-01-01

    Candace Allen’s novel Valaida (2004) illustrates the migratory patterns of early 20th century jazz music and musicians, positing the art form and its performers as “heterotopians”; simultaneously in and outside of the power relations of hegemonic time-space compression, travelling in an alternate...

  7. Time is Life

    CERN Document Server

    Soares, D S L

    2001-01-01

    The affirmative statement of the existence of extraterrestrial life is tentatively raised to the status of a principle. Accordingly, Fermi's question is answered and the anthropic principle is shown to be falsifiable. The time-scale for the development of life on Earth and the age of the universe are the fundamental quantities upon which the arguments are framed.

  8. In Time of War.

    Science.gov (United States)

    Becker, Patti Clayton

    2003-01-01

    Examines the role of libraries, particularly public libraries, in times of war. Discusses similarities between responses after World War Two and the September 11, 2001 attacks; government restrictions on information; American Library Association responses, including propaganda and libraries; and the library and the community. (LRW)

  9. Time to Move On?

    DEFF Research Database (Denmark)

    Valentino, Alfredo; Nell, Phillip; Hotho, Jasper

    2013-01-01

    economic crises influence the effects of the institutional factors in our model. We argue that economic crises have a dual effect on the international configuration of HQ activities. First, during times of crisis, we expect firms to react stronger to coercive, isomorphic, and normative pressures. Second...

  10. Visual time series analysis

    DEFF Research Database (Denmark)

    Fischer, Paul; Hilbert, Astrid

    2012-01-01

    commands, our application is select-and-click-driven. It allows to derive many different sequences of deviations for a given time series and to visualize them in different ways in order to judge their expressive power and to reuse the procedure found. For many transformations or model-ts, the user may...

  11. Time to Reflect

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    U.S. lawmakers admonish Japanese right-wing politicians by demanding an "unambiguous" apology for wartime sex slaves Japan’s controversial stance on its activities during World War II recently sparked a new round of international political contention. But this time, the center of the storm is not its Asian neighbors like China and South Korea

  12. Space-time structure

    CERN Document Server

    Schrödinger, Erwin

    1985-01-01

    In response to repeated requests this classic book on space-time structure by Professor Erwin Schrödinger is now available in the Cambridge Science Classics series. First published in 1950, and reprinted in 1954 and 1960, this lucid and profound exposition of Einstein's 1915 theory of gravitation still provides valuable reading for students and research workers in the field.

  13. The First Time

    Science.gov (United States)

    Black, Beth

    2011-01-01

    In this article, the author narrates her experience of meeting a Montessori kid for the first time and shares the characteristics she observed in Montessori students. The author was working as director of academic resources in university housing at the University of Wisconsin-Madison and met Jason, a pre-med sophomore who was the resident…

  14. Time for Renewal

    Science.gov (United States)

    Nielsen, Patricia D.

    2004-01-01

    During hard economic times, college health professionals must urge their supervisors and administrators to help them maintain or find new funding so that they can attend regional and national conferences of the American College Health Association. In this viewpoint, a nurse from a small college shares the various sources of funding she discovered…

  15. Once Upon a Time

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    THIS is not the start of an oldstory but a new eating experience in Beijing.Once Upon aTime Restaurant(also called RoseGarden Cafe & Bar)is located to thenorth of the Beijing Friendship Store(17 Jianguomenwai Dajie,ChaoyangDistrict),and provides a fresh newcuisine and environment to friends whoare interested in mysterions Arabianculture.

  16. Time and Logic

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2009-01-01

    This paper deals with A.N. Prior's analysis of the concepts of dynamic and static time, i.e. McTaggart's so-called A- and B-concepts. The relations and mutual dependencies between these temporal concepts are investigated, and Prior's response to McTaggart's views is discussed. Futhermore, Prior's...

  17. Time-Darts

    DEFF Research Database (Denmark)

    Jørgensen, Kenneth Yrke; Larsen, Kim Guldstrand; Srba, Jiri

    2012-01-01

    Symbolic data structures for model checking timed systems have been subject to a significant research, with Difference Bound Matrices (DBMs) still being the preferred data structure in several mature verification tools. In comparison, discretization offers an easy alternative, with all operations...

  18. Taking Care of Time

    Directory of Open Access Journals (Sweden)

    Cortney Davis

    2007-01-01

    Full Text Available So take good care of time, therefore and how you spend it. -from " The Cloud of Unknowing"Yesterday it was a thousand small coinsringing in your pocket, your hand dipping in, scooping threeat a time, giving them away. Often you'd drop onein the lush grass, unaware it was lost.Spent, tarnished, it is irretrievable.Today time comes to you in a different disguise:a bold of fine silk, vermillion or blue, you measure itlike a woman preparing to sew.Tomorrow, watch out, it comes as something else-thunderstorm, slant rain, February blizzard that drives you inside.Insomniac, you pace and cursethe blue glow of television, computer screen, radio.Soon enough, time will come to you as you were once,newly born and difficult to recognize. You could mistake itfor an elderly coughing man or a woman overrun with disease.Do not stop your ears against its cry.It will ask you to return any small change.It will say, cherish every moment under the leaden sky.

  19. EXERCISE AND REACTION TIMES

    Directory of Open Access Journals (Sweden)

    Varun

    2015-03-01

    Full Text Available OBJECTIVES: Physical exercise provides multiple benefits to an individual. It is known that exercising regularly can prevent coronary heart disease, hypertension and obesity and improve flexibility. The effect of exercise on visual reaction time needs to be studied, a s the existing data on the benefit of aerobic exercise on psychomotor functions is insufficient. MATERIALS AND METHODS: Online Visual reaction time is measured before and after exercise. Subjects were instructed to run on the spot with a springy step in ex aggerated motion for 50 to 60 counts at 2 counts per second, maintaining a constant rhythm. RESULTS: We observed that reaction time was significantly lower after performance of exercise. Individuals reported improved mental alertness, feel good factor, bet ter mood and increase circulation. CONCLUSION: Improving reaction times in sports can help the athlete to optimize his performance in making decisions and increasing attention span for example getting off the starting blocks sooner or successfully making c ontact with the ball. In addition this study shows that use of physical exercise helps improve cognitive function. Exercise proves to be a cheap non pharmacological alternative to improve cognitive performance.

  20. The SIM Time Network.

    Science.gov (United States)

    Lombardi, Michael A; Novick, Andrew N; Lopez R, J Mauricio; Jimenez, Francisco; de Carlos Lopez, Eduardo; Boulanger, Jean-Simon; Pelletier, Raymond; de Carvalho, Ricardo J; Solis, Raul; Sanchez, Harold; Quevedo, Carlos Andres; Pascoe, Gregory; Perez, Daniel; Bances, Eduardo; Trigo, Leonardo; Masi, Victor; Postigo, Henry; Questelles, Anthony; Gittens, Anselm

    2011-01-01

    The Sistema Interamericano de Metrologia (SIM) is a regional metrology organization (RMO) whose members are the national metrology institutes (NMIs) located in the 34 nations of the Organization of American States (OAS). The SIM/OAS region extends throughout North, Central, and South America and the Caribbean Islands. About half of the SIM NMIs maintain national standards of time and frequency and must participate in international comparisons in order to establish metrological traceability to the International System (SI) of units. The SIM time network (SIMTN) was developed as a practical, cost effective, and technically sound way to automate these comparisons. The SIMTN continuously compares the time standards of SIM NMIs and produces measurement results in near real-time by utilizing the Internet and the Global Positioning System (GPS). Fifteen SIM NMIs have joined the network as of December 2010. This paper provides a brief overview of SIM and a technical description of the SIMTN. It presents international comparison results and examines the measurement uncertainties. It also discusses the metrological benefits that the network provides to its participants.

  1. Hard times; Schwere Zeiten

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, Markus

    2012-10-02

    The prices of silicon and solar wafers keep dropping. According to market research specialist IMS research, this is the result of weak traditional solar markets and global overcapacities. While many manufacturers are facing hard times, big producers of silicon are continuing to expand.

  2. Time and Measurement Days

    Science.gov (United States)

    Scargle, Jeffrey D.

    2017-01-01

    Questions in data analysis involving the concepts of time and measurement are often pushed into the background or reserved for a philosophical discussion. Some examples are: a) Is causality a consequence of the laws of physics, or can the arrow of time be reversed? b) Can we determine the arrow of time of an event? c) Do we need the continuum hypothesis for the underlying function in any measurement process? d) Can we say anything about the analyticity of the underlying process of an event? e) Would it be valid to model a non-analytical process as function of time? f) What are the implications of all these questions for classical Fourier techniques? However, in the age of big data gathered either from space missions supplying ultra-precise long time series, or e.g. LIGO data from the ground, the moment to bring these questions to the foreground seems arrived. The limitations of our understanding of some fundamental processes is emphasized by the lack of solution for problems open for more than 2 decades, such as the non-detection of solar g-modes, or the modal identification of main sequence stellar pulsators like delta Scuti stars. Flicker noise or 1/f noise, for example, attributed in solar-like stars to granulation, is analyzed mostly only to apply noise reduction techniques, neither considering the classical problem of 1/f noise that was introduced a 100 years ago, nor taking into account ergodic or non-ergodic solutions that make inapplicable spectral analysis techniques in practice. This topic was discussed by Nicholas W. Watkins during the ITISE meeting held in Granada in 2016. There he presented preliminary results of his research on Mandelbrot's related work. We reproduce here his quotation of Mandelbrot (1999) "There is a sharp contrast between a highly anomalous ("non-white") noise that proceeds in ordinary clock time and a noise whose principal anomaly is that it is restricted to fractal time", suggesting a connection with the above proposed topics that

  3. Time processing in dyscalculia

    Directory of Open Access Journals (Sweden)

    marinella eCappelletti

    2011-12-01

    Full Text Available To test whether atypical number development may affect other types of quantity processing, we investigated temporal discrimination in adults with developmental dyscalculia (DD. This also allowed us to test whether (1 number and time may be sub-served by a common quantity system or decision mechanisms –in which case they may both be impaired, or (2 whether number and time are distinct –and therefore they may dissociate. Participants judged which of two successively presented horizontal lines was longer in duration, the first line being preceded by either a small or a large number prime (‘1’ or ‘9’ or by a neutral symbol (‘#’, or in third task decide which of two Arabic numbers (either ‘1’, ‘5’, ’9’ lasted longer. Results showed that (i DD’s temporal discriminability was normal as long as numbers were not part of the experimental design even as task-irrelevant stimuli; however (ii task-irrelevant numbers dramatically disrupted DD’s temporal discriminability, the more their salience increased, though the actual magnitude of the numbers had no effect; and in contrast (iii controls’ time perception was robust to the presence of numbers but modulated by numerical quantity such that small number primes or numerical stimuli made durations appear shorter than veridical and the opposite for larger numerical prime or numerical stimuli. This study is the first to investigate continuous quantity as time in a population with a congenital number impairment and to show that atypical development of numerical competence leaves continuous quantity processing spared. Our data support the idea of a partially shared quantity system across numerical and temporal dimensions, which allows dissociations and interactions among dimensions; furthermore, they suggest that impaired number in DD is unlikely to originate from systems initially dedicated to continuous quantity processing like time.

  4. Time Varying Feature Data

    Science.gov (United States)

    Echterhoff, J.; Simonis, I.; Atkinson, R.

    2012-04-01

    The infrastructure to gather, store and access information about our environment is improving and growing rapidly. The increasing amount of information allows us to get a better understanding of the current state of our environment, historical processes and to simulate and predict the future state of the environment. Finer grained spatial and temporal data and more reliable communications make it easier to model dynamic states and ephemeral features. The exchange of information within and across geospatial domains is facilitated through the use of harmonized information models. The Observations & Measurements (O&M) developed through OGC and standardised by ISO is an example of such a cross-domain information model. It is used in many domains, including meteorology, hydrology as well as the emergency management. O&M enables harmonized representation of common metadata that belong to the act of determining the state of a feature property, whether by sensors, simulations or humans. In addition to the resulting feature property value, information such as the result quality but especially the time that the result applies to the feature property can be represented. Temporal metadata is critical to modelling past and future states of a feature. The features, and the semantics of each property, are defined in domain specific Application Schema using the General Feature Model (GFM) from ISO 19109 and usually encoded following ISO 19136. However, at the moment these standards provide only limited support for the representation and handling of time varying feature data. Features like rivers, wildfires or gas plumes have a defined state - for example geographic extent - at any given point in time. To keep track of changes, a more complex model for example using time-series coverages is required. Furthermore, the representation and management of feature property value changes via the service interfaces defined by OGC and ISO - namely: WFS and WCS - would be rather complex

  5. Relativistic time transfer for a Mars lander: from proper time to Areocentric Coordinate Time

    National Research Council Canada - National Science Library

    De-Wang Xu Qing-Shan Yu Yi Xie

    2016-01-01

    As the first step in relativistic time transfer for a Mars lander from its proper time to the time scale at the ground station, we investigate the transformation between proper time and Areocentric Coordinate Time (TCA...

  6. Time Use on Trains

    DEFF Research Database (Denmark)

    Bjørner, Thomas

    2016-01-01

    This study explores how travel time is used and how passengers conceptualise travel time in Danish intercity trains and intercity fast trains. The new contribution to the literature this study can offer is in the inclusion of all kinds of passengers in the different compartments to understand train...... travel as a dynamic act of moving with shifts in activities. A mixed-method approach is used with self-completed questionnaires, frequency observations, shadowing observations and interviews. The findings reveal that the train passengers’ acts on the move are framed by both macro- and microstructures....... The passengers create a travel space in which they make dynamic shifts in different kinds of activities: media use, media non-use, social interactions and non-social interactions. Passengers expect the train operator to provide the travel space for different activities (including the possibility of mobile...

  7. Creating Space and Time

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Refslund Christensen, Dorthe

    (‘memories’) for their deceased loved ones and get personal, social support in their mourning processes through communication with other mourners, through mutual appreciation of each other’s postings and through emotional labor reflected on the individual sites. The main focus in this paper is how online...... and very young children) and suggest that the process of producing memories needs to be understood in the light of there having been very little actual time and life spend with the child (if any at all) and that this lack of time is met by narrative and performative strategies aiming at providing a common...... the spatial, materialized and medialized strategies for keeping the child socially alive within the social life of the family and point to the socio-cultural matrices of these practices: The extensive use of props such as pictures, written material (poems, letters) and – on the graves (along with e...

  8. Kaolin clotting time.

    Science.gov (United States)

    Radhakrishnan, Kottayam

    2013-01-01

    The kaolin clotting time (KCT) is a sensitive test used in the laboratory detection of lupus anticoagulants (LA) (Derksen and de Groot, Thromb Res 114:521-526, 2004). It is essentially an activated partial thromboplastin time (APTT) test with no added phospholipid. Kaolin acts as the activator in the KCT. In the absence of additional phospholipid reagent, the quality of the test sample is extremely important since the generation of thrombin completely depends on the presence of residual cell membranes and plasma lipids (Derksen and de Groot, Thromb Res 114:521-526, 2004). Since the test contains no exogenous phospholipid, a confirmatory test using excess phospholipid is required to confirm the presence of lupus anticoagulant in the sample (Court, Br J Biomed Sci 54:287-298, 1997).

  9. Time and Citation Networks

    CERN Document Server

    Clough, James R

    2015-01-01

    Citation networks emerge from a number of different social systems, such as academia (from published papers), business (through patents) and law (through legal judgements). A citation represents a transfer of information, and so studying the structure of the citation network will help us understand how knowledge is passed on. What distinguishes citation networks from other networks is time; documents can only cite older documents. We propose that existing network measures do not take account of the strong constraint imposed by time. We will illustrate our approach with two types of causally aware analysis. We apply our methods to the citation networks formed by academic papers on the arXiv, to US patents and to US Supreme Court judgements. We show that our tools can reveal that citation networks which appear to have very similar structure by standard network measures turn out to have significantly different properties. We interpret our results as indicating that many papers in a bibliography were not directly...

  10. Real time production optimization

    Energy Technology Data Exchange (ETDEWEB)

    Saputelli, Luigi; Otavio, Joao; Araujo, Turiassu; Escorcia, Alvaro [Halliburton, Houston, TX (United States). Landmark Division

    2004-07-01

    Production optimization encompasses various activities of measuring, analyzing, modeling, prioritizing and implementing actions to enhance productivity of a field. We present a state-of-the-art framework for optimizing production on a continuous basis as new sensor data is acquired in real time. Permanently acquired data is modeled and analyzed in order to create predictive models. A model based control strategy is used to regulate well and field instrumentation. The optimum field operating point, which changes with time, satisfies the maximum economic return. This work is a starting point for further development in automatic, intelligent reservoir technologies which get the most out of the abilities of permanent, instrumented wells and remotely activated downhole completions. The strategy, tested with history-matched data from a compartmentalised giant field, proved to reduce operating costs while increasing oil recovery by 27% in this field. (author)

  11. Tracking change over time

    Science.gov (United States)

    ,

    2011-01-01

    Landsat satellites capture images of Earth from space-and have since 1972! These images provide a long-term record of natural and human-induced changes on the global landscape. Comparing images from multiple years reveals slow and subtle changes as well as rapid and devastating ones. Landsat images are available over the Internet at no charge. Using the free software MultiSpec, students can track changes to the landscape over time-just like remote sensing scientists do! The objective of the Tracking Change Over Time lesson plan is to get students excited about studying the changing Earth. Intended for students in grades 5-8, the lesson plan is flexible and may be used as a student self-guided tutorial or as a teacher-led class lesson. Enhance students' learning of geography, map reading, earth science, and problem solving by seeing landscape changes from space.

  12. Real time production optimization

    Energy Technology Data Exchange (ETDEWEB)

    Saputelli, Luigi; Otavio, Joao; Araujo, Turiassu; Escorcia, Alvaro [Halliburton, Houston, TX (United States). Landmark Division

    2004-07-01

    Production optimization encompasses various activities of measuring, analyzing, modeling, prioritizing and implementing actions to enhance productivity of a field. We present a state-of-the-art framework for optimizing production on a continuous basis as new sensor data is acquired in real time. Permanently acquired data is modeled and analyzed in order to create predictive models. A model based control strategy is used to regulate well and field instrumentation. The optimum field operating point, which changes with time, satisfies the maximum economic return. This work is a starting point for further development in automatic, intelligent reservoir technologies which get the most out of the abilities of permanent, instrumented wells and remotely activated downhole completions. The strategy, tested with history-matched data from a compartmentalised giant field, proved to reduce operating costs while increasing oil recovery by 27% in this field. (author)

  13. Discounting in Time

    DEFF Research Database (Denmark)

    Fahrenberg, Uli; Larsen, Kim Guldstrand

    2009-01-01

    This paper deals with the issue of discounting in weighted timed transition systems. Discounting provides a way to model optimal-cost problems for infinite runs and has applications in optimal scheduling and other areas. We show that when postulating a certain natural additivity property for the ......This paper deals with the issue of discounting in weighted timed transition systems. Discounting provides a way to model optimal-cost problems for infinite runs and has applications in optimal scheduling and other areas. We show that when postulating a certain natural additivity property...... for the discounted weights of runs, there is essentially only one possible way to introduce a discounting semantics. Our proof relies on the fact that a certain functional equation essentially only has one solution, for which we provide an elementary proof....

  14. Time ripe for superconductivity?

    Directory of Open Access Journals (Sweden)

    George Marsh

    2002-04-01

    But there is a crucial deadline and failure to meet it could send superconductivity back to the commercial shadows (at least outside the medical and scientific niches where it is a key enabler in analytical instruments, magnetic resonance imaging, and particle accelerators for another 30 years. Later this decade, the vintage infrastructure of dense copper conductors that supports power distribution in developed countries, in particular in the US, will become due for renewal. (Recent power problems in California were largely those of distribution infrastructure. At the same time, boosting capacity to serve the needs of increasingly affluent populations will pose a challenge. Superconductivity could provide the answer — if the technology matures in time and cost targets are met.

  15. Pulse Portraiture: Pulsar timing

    Science.gov (United States)

    Pennucci, Timothy T.; Demorest, Paul B.; Ransom, Scott M.

    2016-06-01

    Pulse Portraiture is a wideband pulsar timing code written in python. It uses an extension of the FFTFIT algorithm (Taylor 1992) to simultaneously measure a phase (TOA) and dispersion measure (DM). The code includes a Gaussian-component-based portrait modeling routine. The code uses the python interface to the pulsar data analysis package PSRCHIVE (ascl:1105.014) and also requires the non-linear least-squares minimization package lmfit (ascl:1606.014).

  16. Time processing in dyscalculia.

    Science.gov (United States)

    Cappelletti, Marinella; Freeman, Elliot D; Butterworth, Brian L

    2011-01-01

    To test whether atypical number development may affect other types of quantity processing, we investigated temporal discrimination in adults with developmental dyscalculia (DD). This also allowed us to test whether number and time may be sub-served by a common quantity system or decision mechanisms: if they do, both should be impaired in dyscalculia, but if number and time are distinct they should dissociate. Participants judged which of two successively presented horizontal lines was longer in duration, the first line being preceded by either a small or a large number prime ("1" or "9") or by a neutral symbol ("#"), or in a third task participants decided which of two Arabic numbers (either "1," "5," "9") lasted longer. Results showed that (i) DD's temporal discriminability was normal as long as numbers were not part of the experimental design, even as task-irrelevant stimuli; however (ii) task-irrelevant numbers dramatically disrupted DD's temporal discriminability the more their salience increased, though the actual magnitude of the numbers had no effect; in contrast (iii) controls' time perception was robust to the presence of numbers but modulated by numerical quantity: therefore small number primes or numerical stimuli seemed to make durations appear shorter than veridical, but longer for larger numerical prime or numerical stimuli. This study is the first to show spared temporal discrimination - a dimension of continuous quantity - in a population with a congenital number impairment. Our data reinforce the idea of a partially shared quantity system across numerical and temporal dimensions, which supports both dissociations and interactions among dimensions; however, they suggest that impaired number in DD is unlikely to originate from systems initially dedicated to continuous quantity processing like time.

  17. Gravity, Time, and Lagrangians

    Science.gov (United States)

    Huggins, Elisha

    2010-01-01

    Feynman mentioned to us that he understood a topic in physics if he could explain it to a college freshman, a high school student, or a dinner guest. Here we will discuss two topics that took us a while to get to that level. One is the relationship between gravity and time. The other is the minus sign that appears in the Lagrangian. (Why would one…

  18. Real Time Baseball Database

    Science.gov (United States)

    Fukue, Yasuhiro

    The author describes the system outline, features and operations of "Nikkan Sports Realtime Basaball Database" which was developed and operated by Nikkan Sports Shimbun, K. K. The system enables to input numerical data of professional baseball games as they proceed simultaneously, and execute data updating at realtime, just-in-time. Other than serving as supporting tool for prepareing newspapers it is also available for broadcasting media, general users through NTT dial Q2 and others.

  19. Real Time Processing

    CERN Document Server

    CERN. Geneva; ANDERSON, Dustin James; DOGLIONI, Caterina

    2015-01-01

    The LHC provides experiments with an unprecedented amount of data. Experimental collaborations need to meet storage and computing requirements for the analysis of this data: this is often a limiting factor in the physics program that would be achievable if the whole dataset could be analysed. In this talk, I will describe the strategies adopted by the LHCb, CMS and ATLAS collaborations to overcome these limitations and make the most of LHC data: data parking, data scouting, and real-time analysis.

  20. Time to move on?

    CERN Document Server

    Ellis, John

    2017-01-01

    Cosmology and particle physics have long been dominated by theoretical paradigms: Einstein's general theory of relativity in cosmology and the Standard Model of particle physics. The time may have come for paradigm shifts. Does cosmological inflation require a modification of Einstein's gravity? Have experiments at the LHC discovered a new particle beyond the Standard Model? It is premature to answer these questions, but we theorists can dream about the possibilities.

  1. Theoretical Delay Time Distributions

    CERN Document Server

    Nelemans, Gijs; Bours, Madelon

    2012-01-01

    We briefly discuss the method of population synthesis to calculate theoretical delay time distributions of type Ia supernova progenitors. We also compare the results of the different research groups and conclude that although one of the main differences in the results for single degenerate progenitors is the retention efficiency with which accreted hydrogen is added to the white dwarf core, this cannot explain all the differences.

  2. Theoretical Delay Time Distributions

    Science.gov (United States)

    Nelemans, Gijs; Toonen, Silvia; Bours, Madelon

    2013-01-01

    We briefly discuss the method of population synthesis to calculate theoretical delay time distributions of Type Ia supernova progenitors. We also compare the results of different research groups and conclude that, although one of the main differences in the results for single degenerate progenitors is the retention efficiency with which accreted hydrogen is added to the white dwarf core, this alone cannot explain all the differences.

  3. Geometric Time Delay Interferometry

    OpenAIRE

    Vallisneri, Michele

    2005-01-01

    The space-based gravitational-wave observatory LISA, a NASA-ESA mission to be launched after 2012, will achieve its optimal sensitivity using Time Delay Interferometry (TDI), a LISA-specific technique needed to cancel the otherwise overwhelming laser noise in the inter-spacecraft phase measurements. The TDI observables of the Michelson and Sagnac types have been interpreted physically as the virtual measurements of a synthesized interferometer. In this paper, I present Geometric TDI, a new an...

  4. Happy time at school

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    I like the ten minutes’breaks at school. They are very important to me.I’m always tired after each class.The ten minutes’break gives me a good rest.During the ten minutes,we talk, laugh,sing,dance and do what we like to do. That is one of my happiest time at school.I’m sure every student likes the ten minutes’break.

  5. Pulsar Timing Arrays

    OpenAIRE

    Joshi, Bhal Chandra

    2013-01-01

    In the last decade, the use of an ensemble of radio pulsars to constrain the characteristic strain caused by a stochastic gravitational wave background has advanced the cause of detection of very low frequency gravitational waves significantly. This electromagnetic means of gravitational wave detection, called Pulsar Timing Array(PTA), is reviewed in this article. The principle of operation of PTA, the current operating PTAs and their status is presented along-with a discussion of the main ch...

  6. These Synthetic Times

    Institute of Scientific and Technical Information of China (English)

    KIT GILLET

    2008-01-01

    @@ Already slated to be one of the most important cultural events in the buildup to this summer's Olympic games, Synthetic Times-Media Art China 2008 will feature the works of more than 30 artists from around the world. Upwards of 40 media art installations will be exhibited in the National Art Museum of China alone, along with performances, workshops, presentations, and discussion panels focusing on the art works and the growth of media art as a discipline.

  7. Real Time Econometrics

    OpenAIRE

    Pesaran, M. Hashem; Timmermann, Allan

    2004-01-01

    This paper considers the problems facing decision makers using econometric models in real time. It identifies the key stages involved and highlights the role of automated systems in reducing the effect of data snooping. It sets out many choices that researchers face in construction of automated systems and discusses some of the possible ways advanced in the literature for dealing with them. The role of feedbacks from the decision maker?s actions to the data generating process is also discusse...

  8. It's Time to Fly

    Institute of Scientific and Technical Information of China (English)

    陈尚岚

    2005-01-01

    There is long history and tradition of acrobatics in the central plains. Puyang Acrobatic Art Troupe was developed through three generations' hard endeavor. Ren Qingran, the grandfather of Ren Xuezhen, is proficient in acrobatic stunt. He organized Ren's goup in 1968 wandering in the streets and villages to perform acrobatic acts to make their livings. Later the local government organized one acrobatic team on the basis of members from Ren's to develop literature and art activities. However, good times ...

  9. Time at the beginning

    Energy Technology Data Exchange (ETDEWEB)

    Michael S. Turner

    2002-10-11

    Age consistency for the Universe today has been an important cosmological test. Even more powerful consistency tests at times as early as 10{sup -32} sec lie ahead in the precision era of cosmology. I outline tests based upon cosmic microwave background (CMB) anisotropy, big-bang nucleosynthesis (BBN), particle dark matter, phase transitions, and inflation. The ultimate cosmic timescale--the fate of the Universe--will be in doubt until the mystery of the dark energy is unraveled.

  10. Gravity, Time, and Lagrangians

    Science.gov (United States)

    Huggins, Elisha

    2010-01-01

    Feynman mentioned to us that he understood a topic in physics if he could explain it to a college freshman, a high school student, or a dinner guest. Here we will discuss two topics that took us a while to get to that level. One is the relationship between gravity and time. The other is the minus sign that appears in the Lagrangian. (Why would one…

  11. Metrology and Time

    CERN Document Server

    Rybak, B

    1999-01-01

    The algorithm Pi/sinx reveals an elliptic excess which acts as the real component (Space) inducing the imaginary component (Time). Key words : metrology, chronogenesis, tropic year, anomalistic year. ----- L 'algorithme Pi/sinx revele un excedent elliptique constituant la composante active d ' espace dont la composante reactive exprime la chronogenese tropique aussi bien qu ' anomalistique.. Mots-cles : metrologie, chronogenese, annee tropique, annee anomalistique

  12. Deep Time Contagion

    Directory of Open Access Journals (Sweden)

    Andy Weir

    2012-11-01

    Full Text Available An artist from London researching the effects of deprioritised subjectivity and contemporary art, Weir presents acoustic recordings made in deep geological repository sites. Repurposing these sites from their typical use as storage space for nuclear waste, Weir addresses the extra-human scale of Deep Time through sonic-fiction. Inhumanly enduring and impinging upon humanity largely imperceptibly, what agency—at what scale—is present?

  13. Admissible Evacuation Time

    OpenAIRE

    Jemeļjanovs, V; Malahova, J; Ziemelis, M; Bartušauskis, J; Sņegovs, O

    2012-01-01

    Fire always is unexpected. Therefore, to decrease count of victims during the panic, it is essential to timely leave a dangerous place. Unfortunately, quick and smooth evacuation is not possible in many buildings where fire safety should be at the highest level. One of the greatest civil threat risks is obstacles that impede escape from fire or other incident that can happen in the building. Therefore, more precise research and methododoly are needed for determination ...

  14. Music in Galileo's Time

    Science.gov (United States)

    Petrobelli, P.

    2011-06-01

    Claudio Monteverdi appears as the key personality of the music in Galileo's time. His revolution in format and function of the musical language-from an essentially edonistic creation of purely sonorous images to a musical language consciously "expressive" of the content of the words on which it is based-is similar in character to the influential innovations in scientific thinking operated by Galileo.

  15. Strange science takes time

    CERN Multimedia

    2008-01-01

    The late astronomer Carl Sagan popularized the saying that "extraordinary claims require extraordinary evidence," in reference to reports of alien visitations. Generating low-cost commercial fusion power, isolating antimatter and tracing reverse-time causality aren't as far out there as UFOs, but a similar rule might well apply: Extraordinary science requires extraordinary effort. With that in mind, here's a progress report on three extraordinary science projects that have popped up in the news...

  16. Time to Withdraw?

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ As the new year progresses,policymakers around the world are asking themselves the same question: Is it time to halt stimulus policies? But the question seems almost unanswerable now as signs of inflation proliferate while the global economy has yet to find its feet.Zhu Daming,a Shanghai-based independent analyst,discussed this issue in an article recently published in the Economic Information Daily.

  17. Time Reversal Violation

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, H; /SLAC

    2009-01-27

    This talk briefly reviews three types of time-asymmetry in physics, which I classify as universal, macroscopic and microscopic. Most of the talk is focused on the latter, namely the violation of T-reversal invariance in particle physics theories. In sum tests of microscopic T-invariance, or observations of its violation, are limited by the fact that, while we can measure many processes, only in very few cases can we construct a matched pair of process and inverse process and observe it with sufficient sensitivity to make a test. In both the cases discussed here we can achieve an observable T violation making use of flavor tagging, and in the second case also using the quantum properties of an antisymmetric coherent state of two B mesons to construct a CP-tag. Both these tagging properties depend only on very general properties of the flavor and/or CP quantum numbers and so provide model independent tests for T-invariance violations. The microscopic laws of physics are very close to T-symmetric. There are small effects that give CP- and T-violating processes in three-generation-probing weak decays. Where a T-violating observable can be constructed we see the relationships between T-violation and CP-violation expected in a CPT conserving theory. These microscopic effects are unrelated to the 'arrow of time' that is defined by increasing entropy, or in the time direction defined by the expansion of our Universe.

  18. Timing Foreign Exchange Markets

    Directory of Open Access Journals (Sweden)

    Samuel W. Malone

    2016-03-01

    Full Text Available To improve short-horizon exchange rate forecasts, we employ foreign exchange market risk factors as fundamentals, and Bayesian treed Gaussian process (BTGP models to handle non-linear, time-varying relationships between these fundamentals and exchange rates. Forecasts from the BTGP model conditional on the carry and dollar factors dominate random walk forecasts on accuracy and economic criteria in the Meese-Rogoff setting. Superior market timing ability for large moves, more than directional accuracy, drives the BTGP’s success. We explain how, through a model averaging Monte Carlo scheme, the BTGP is able to simultaneously exploit smoothness and rough breaks in between-variable dynamics. Either feature in isolation is unable to consistently outperform benchmarks throughout the full span of time in our forecasting exercises. Trading strategies based on ex ante BTGP forecasts deliver the highest out-of-sample risk-adjusted returns for the median currency, as well as for both predictable, traded risk factors.

  19. Time, music, and reverie.

    Science.gov (United States)

    Lombardi, Riccardo

    2008-12-01

    Time is an important source of containment vis-à-vis the pressure of affects and the nondimensional immensity of mental space experienced by difficult patients. A more articulated spatiotemporal integration can be facilitated by the analyst's musical "reverie" during intense emotional exchanges in analytic sessions. This reverie can be visual, olfactory, kinaesthetic, etc., no less than auditory or musical. Music is indeed connected with both the concrete world of bodily sensations and the symbolic expressions of culture, and may be an important transitional phenomenon in analytic communication on both unconscious and conscious levels. Two clinical cases are presented in which the patient's awareness of the passage of time, associated with the analyst's internal musical experiences, made it possible in one case to reduce intense panic attacks and, in the other, to overcome the patient's rigid obsessive defenses, giving him access to fluid and unforeseen emotions. In these two instances of working through, the perception of time helped establish confidence in the creative contribution of the "unheard melodies" (Keats) of affects to the functioning of thought.

  20. The thermodynamics of time

    CERN Document Server

    Sels, Dries

    2015-01-01

    The problem of time is a deep paradox in our physical description of the world. According to Aristotle's relational theory, time is a measure of change and does not exist on its own. In contrast, quantum mechanics, just like Newtonian mechanics, is equipped with a master clock that dictates the evolution of a system. This clock is infinitely precise and tacitly supplied free of charge from outside physics. Not only does this absolute time make it notoriously difficult to make a consistent theory of quantum gravity, it is also the underlying problem in establishing the second law. Indeed, contrary to our experience, the Wheeler-deWitt equation --a canonical quantization of general relativity-- predicts a static universe. Similarly, when simply concerned with the dynamics of a closed quantum system, there is no second law because the Von Neumann entropy is invariant under unitary transformations. Here we are mainly concerned with the latter problem and we show that it can be resolved by attributing a minimal am...

  1. Commission 31: Time

    Science.gov (United States)

    Matsakis, Demetrios; Defraigne, Pascale; Hosokawa, M.; Leschiutta, S.; Petit, G.; Zhai, Z.-C.

    2007-03-01

    The most intensely discussed and controversial issue in time keeping has been the proposal before the International Telecommunications Union (ITU) to redefine Coordinated Universal Time (UTC) so as to replace leap seconds by leap hours. Should this proposal be adopted, the practice of inserting leap seconds would cease after a specific date. Should the Earth's rotation continue to de-accelerate at its historical rate, the next discontinuity in UTC would be an hour inserted several centuries from now. Advocates of this proposal cite the need to synchronize satellite and other systems, such as GPS, Galileo, and GLONASS, which did not exist and were not envisioned when the current system was adopted. They note that leap second insertions can be and have been incorrectly implemented or accounted for. Such errors have to date had localized impact, but they could cause serious mishaps involving loss of life. For example, some GPS receivers have been known to fail simply because there was no leap second after a long enough interval, other GPS receivers failed because the leap second information was broadcast more than three months in advance, and some commercial software used for internet time-transfer Network Time Protocol (NTP) could either discard all data received after a leap second or interpret it as a frequency change. The ambiguity associated with the extra second could also disrupt financial accounting and certain forms of encryption. Those opposed to the proposal question the need for a change, and also point out the costs of adjusting to the proposed change and its inconvenience to amateur astronomers and others who rely upon astronomical calculations published in advance. Reports have been circulated that the cost of checking and correcting software to accommodate the new definition of UTC would be many millions of dollars for some systems. In October 2005 American Astronomical Society asked the ITU for a year's time to study the issue. This commission has

  2. Time to Move On?

    DEFF Research Database (Denmark)

    Valentino, A.; Nell, Phillip Christopher; Hotho, Jasper J.

    Building on prior research, we examine theoretically the institutional factors that push top managers to relocate HQ units overseas. To this end, we first discuss how coercive, isomorphic, and normative pressures may differentially affect HQ relocation decisions. Subsequently, we consider how...... economic crises influence the effects of the institutional factors in our model. We argue that economic crises have a dual effect on the international configuration of HQ activities. First, during times of crisis, we expect firms to react stronger to coercive, isomorphic, and normative pressures. Second...

  3. Time, travel and infection.

    Science.gov (United States)

    Cliff, Andrew; Haggett, Peter

    2004-01-01

    The collapse of geographical space over the last 200 years has had profound effects on the circulation of human populations and on the transfer of infectious diseases. Three examples are used to illustrate the process: (a) the impact of the switch from sail to steamships in importing measles into Fiji over a 40-year period; (b) changes in measles epidemic behaviour in Iceland over a 150-year period; and (c) changes in the spread of cholera within the United States over a 35-year period. In each case, the link between time, travel and disease has been an intimate one.

  4. Time to experiment…

    Directory of Open Access Journals (Sweden)

    Gráinne Conole

    2002-12-01

    Full Text Available In the last edition of ALT-J, the editorial team decided to try an experiment by creating a more interactive and critical debate on a particular article with the journal. Readers were invited to submit comments on an article by Davis and Denning entitled: 'Almost as helpful as good theory: some conceptual possibilities for the online classroom' (Davis and Denning, 2000. Summarized below are some of the key comments raised about the paper. Many thanks to everyone who took the time to send in these comments; individual acknowledgements have not been included for reasons of confidentiality.

  5. Time and Thermodynamics

    CERN Document Server

    Kirkland, Kyle

    2007-01-01

    Temperature is vital to the health and welfare of all living beings, and Earth's temperature varies considerably from place to place. Early humans could only live in warm areas such as the tropics. Although modern humans have the technology to keep their houses and offices warm even in cold environments, the growth and development of civilization has created unintentional effects. Cities are warmer than their surrounding regions, and on a global scale, Earth is experiencing rising temperatures. Thus, the science of thermodynamics offers an important tool to study these effects. "Time and

  6. Knowledge and time

    CERN Document Server

    2017-01-01

    This is a unique volume by a unique scientist, which combines conceptual, formal, and engineering approaches in a way that is rarely seen. Its core is the relation between ways of learning and knowing on the one hand and different modes of time on the other. Partial Boolean logic and the associated notion of complementarity are used to express this relation, and mathematical tools of fundamental physics are used to formalize it. Along the way many central philosophical problems are touched and addressed, above all the mind-body problem. Completed only shortly before the death of the author, the text has been edited and annotated by the author's close collaborator Harald Atmanspacher.

  7. Aid Supplies Over Time

    DEFF Research Database (Denmark)

    Jones, Edward Samuel

    The recent financial crisis has rekindled interest in the foreign aid supply behaviour of bilateral donors. Using the latest data covering the period 1960-2009, this paper examines how such behaviour is related to domestic factors. Based on a simple empirical model, a distinction is made between ...... substantial heterogeneity between countries. There is also good evidence that donor behaviour continues to evolve over time. As such, past trends in aid supplies are unlikely to provide a good guide to those of the future....

  8. Real time Faraday spectrometer

    Science.gov (United States)

    Smith, Jr., Tommy E.; Struve, Kenneth W.; Colella, Nicholas J.

    1991-01-01

    This invention uses a dipole magnet to bend the path of a charged particle beam. As the deflected particles exit the magnet, they are spatially dispersed in the bend-plane of the magnet according to their respective momenta and pass to a plurality of chambers having Faraday probes positioned therein. Both the current and energy distribution of the particles is then determined by the non-intersecting Faraday probes located along the chambers. The Faraday probes are magnetically isolated from each other by thin metal walls of the chambers, effectively providing real time current-versus-energy particle measurements.

  9. Time, classical and quantum

    Science.gov (United States)

    Aniello, P.; Ciaglia, F. M.; Di Cosmo, F.; Marmo, G.; Pérez-Pardo, J. M.

    2016-10-01

    We propose a new point of view regarding the problem of time in quantum mechanics, based on the idea of replacing the usual time operator T with a suitable real-valued function T on the space of physical states. The proper characterization of the function T relies on a particular relation with the dynamical evolution of the system rather than with the infinitesimal generator of the dynamics (Hamiltonian). We first consider the case of classical hamiltonian mechanics, where observables are functions on phase space and the tools of differential geometry can be applied. The idea is then extended to the case of the unitary evolution of pure states of finite-level quantum systems by means of the geometric formulation of quantum mechanics. It is found that T is a function on the space of pure states which is not associated with any self-adjoint operator. The link between T and the dynamical evolution is interpreted as defining a simultaneity relation for the states of the system with respect to the dynamical evolution itself. It turns out that different dynamical evolutions lead to different notions of simultaneity, i.e., the notion of simultaneity is a dynamical notion.

  10. Moments in time

    Directory of Open Access Journals (Sweden)

    Marc eWittmann

    2011-10-01

    Full Text Available It has been suggested that perception and action can be understood as evolving in temporal epochs or sequential processing units. Successive events are fused into units forming a unitary experience or ‘psychological present’. Studies have identified several temporal integration levels on different time scales which are fundamental for our understanding of behaviour and subjective experience. In recent literature concerning the philosophy and neuroscience of consciousness these separate temporal processing levels are not always precisely distinguished. Therefore, empirical evidence from psychophysics and neuropsychology on these distinct temporal processing levels is presented and discussed within philosophical conceptualizations of time experience. On an elementary level, one can identify a functional moment, a basic temporal building block of perception in the range of milliseconds that defines simultaneity and succession. Below a certain threshold temporal order is not perceived, individual events are processed as co-temporal. On a second level, an experienced moment, which is based on temporal integration of up to a few seconds, has been reported in many qualitatively different experiments in perception and action. It has been suggested that this segmental processing mechanism creates temporal windows that provide a logistical basis for conscious representation and the experience of nowness. On a third level of integration, continuity of experience is enabled by working-memory in the range of multiple seconds allowing the maintenance of cognitive operations and emotional feelings, leading to mental presence, a temporal window of an individual’s experienced presence.

  11. Causality between time series

    CERN Document Server

    Liang, X San

    2014-01-01

    Given two time series, can one tell, in a rigorous and quantitative way, the cause and effect between them? Based on a recently rigorized physical notion namely information flow, we arrive at a concise formula and give this challenging question, which is of wide concern in different disciplines, a positive answer. Here causality is measured by the time rate of change of information flowing from one series, say, X2, to another, X1. The measure is asymmetric between the two parties and, particularly, if the process underlying X1 does not depend on X2, then the resulting causality from X2 to X1 vanishes. The formula is tight in form, involving only the commonly used statistics, sample covariances. It has been validated with touchstone series purportedly generated with one-way causality. It has also been applied to the investigation of real world problems; an example presented here is the cause-effect relation between two climate modes, El Ni\\~no and Indian Ocean Dipole, which have been linked to the hazards in f...

  12. Is Time's Arrow Perspectival?

    CERN Document Server

    Rovelli, Carlo

    2015-01-01

    We observe entropy decrease towards the past. Does this imply that in the past the world was in a non-generic microstate? I point out an alternative. The subsystem to which we belong interacts with the universe via a relatively small number of quantities, which define a coarse graining. Entropy happens to depends on coarse-graining. Therefore the entropy we ascribe to the universe depends on the peculiar coupling between us and the rest of the universe. Low past entropy may be due to the fact that this coupling (rather than microstate of the universe) is non-generic. I argue that for any generic microstate of a sufficiently rich system there are always special subsystems defining a coarse graining for which the entropy of the rest is low in one time direction (the "past"). These are the subsystems allowing creatures that "live in time" ---such as those in the biosphere--- to exist. I reply to some objections raised to an earlier presentation of this idea, in particular by Bob Wald, David Albert and Jim Hartle...

  13. HAWC Timing Calibration

    CERN Document Server

    Huentemeyer, Petra; Dingus, Brenda

    2009-01-01

    The High-Altitude Water Cherenkov (HAWC) Experiment is a second-generation highsensitivity gamma-ray and cosmic-ray detector that builds on the experience and technology of the Milagro observatory. Like Milagro, HAWC utilizes the water Cherenkov technique to measure extensive air showers. Instead of a pond filled with water (as in Milagro) an array of closely packed water tanks is used. The event direction will be reconstructed using the times when the PMTs in each tank are triggered. Therefore, the timing calibration will be crucial for reaching an angular resolution as low as 0.25 degrees.We propose to use a laser calibration system, patterned after the calibration system in Milagro. Like Milagro, the HAWC optical calibration system will use ~1 ns laser light pulses. Unlike Milagro, the PMTs are optically isolated and require their own optical fiber calibration. For HAWC the laser light pulses will be directed through a series of optical fan-outs and fibers to illuminate the PMTs in approximately one half o...

  14. Physics Back in TIME

    Science.gov (United States)

    Korsunsky, Boris

    2014-03-01

    Recently, I came into possession of an unusual item: a collection of 1928 TIME magazines. I began flipping through the pages out of sheer curiosity—and was soon astonished by the scale and the depth of their physics coverage. Back then, TIME had a special "Science" section in almost every issue and devoted quite a bit of space to the events that would hardly be mentioned in any popular magazine these days. Some of them were fleeting and merely curious, some truly timeless. Many of the articles and notes were devoted to physics: the people, the discoveries, the inventions, the conventions. I found the reading both entertaining and enlightening and would like to offer a sampler here. I hope that these little tidbits of history will lighten up the classroom discussions and help inspire your students by reminding them that physics is a dynamic, ever-changing field to which they may well contribute one day. I have found that my own students love it when a little bit of history is brought up; it always generates interesting questions and seems to spark the students' interest in the topic.

  15. Timing of cyber conflict.

    Science.gov (United States)

    Axelrod, Robert; Iliev, Rumen

    2014-01-28

    Nations are accumulating cyber resources in the form of stockpiles of zero-day exploits as well as other novel methods of engaging in future cyber conflict against selected targets. This paper analyzes the optimal timing for the use of such cyber resources. A simple mathematical model is offered to clarify how the timing of such a choice can depend on the stakes involved in the present situation, as well as the characteristics of the resource for exploitation. The model deals with the question of when the resource should be used given that its use today may well prevent it from being available for use later. The analysis provides concepts, theory, applications, and distinctions to promote the understanding strategy aspects of cyber conflict. Case studies include the Stuxnet attack on Iran's nuclear program, the Iranian cyber attack on the energy firm Saudi Aramco, the persistent cyber espionage carried out by the Chinese military, and an analogous case of economic coercion by China in a dispute with Japan. The effects of the rapidly expanding market for zero-day exploits are also analyzed. The goal of the paper is to promote the understanding of this domain of cyber conflict to mitigate the harm it can do, and harness the capabilities it can provide.

  16. Emergent Space-Time

    Science.gov (United States)

    Chapline, George

    It has been shown that a nonlinear Schrödinger equation in 2+1 dimensions equipped with an SU(N) Chern-Simons gauge field can provide an exact description of certain self-dual Einstein spaces in the limit N-=∞. Ricci flat Einstein spaces can then be viewed as arising from a quantum pairing of the classical self-dual and anti-self-dual solutions. In this chapter, we will outline how this theory of empty space-time might be generalized to include matter and vacuum energy by transplanting the nonlinear Schrödinger equation used to construct Einstein spaces to the 25+1-dimensional Lorentzian Leech lattice. If the distinguished 2 spatial dimensions underlying the construction of Einstein spaces are identified with a hexagonal lattice section of the Leech lattice, the wave-function becomes an 11 × 11 matrix that can represent fermion and boson degrees of freedom (DOF) associated with 2-form and Yang-Mills gauge symmetries. The resulting theory of gravity and matter in 3+1 dimensions is not supersymmetric, which provides an entry for a vacuum energy. Indeed, in the case of a Lemaitre cosmological model, the emergent space-time will naturally have a vacuum energy on the order of the observed cosmological constant.

  17. Time-Delay Interferometry

    Directory of Open Access Journals (Sweden)

    Massimo Tinto

    2014-08-01

    Full Text Available Equal-arm detectors of gravitational radiation allow phase measurements many orders of magnitude below the intrinsic phase stability of the laser injecting light into their arms. This is because the noise in the laser light is common to both arms, experiencing exactly the same delay, and thus cancels when it is differenced at the photo detector. In this situation, much lower level secondary noises then set the overall performance. If, however, the two arms have different lengths (as will necessarily be the case with space-borne interferometers, the laser noise experiences different delays in the two arms and will hence not directly cancel at the detector. In order to solve this problem, a technique involving heterodyne interferometry with unequal arm lengths and independent phase-difference readouts has been proposed. It relies on properly time-shifting and linearly combining independent Doppler measurements, and for this reason it has been called time-delay interferometry (TDI. This article provides an overview of the theory, mathematical foundations, and experimental aspects associated with the implementation of TDI. Although emphasis on the application of TDI to the Laser Interferometer Space Antenna (LISA mission appears throughout this article, TDI can be incorporated into the design of any future space-based mission aiming to search for gravitational waves via interferometric measurements. We have purposely left out all theoretical aspects that data analysts will need to account for when analyzing the TDI data combinations.

  18. Date and Time

    Institute of Scientific and Technical Information of China (English)

    ZhangJingxian

    1996-01-01

    Nowadays the pace of social life is very fast.TO make clear date and time is very important to everyone,especially those who are away fromhome.You need to learn ways to express date and time in Chinese.Otherwise how can you make arrangements with your Chinese friends?41.请问,今天(是)几号?Qǐngwèn,jīntiān(shǐ)jǐ hào?(May I ask,what is the date today?)In Chinese,jǐntiān.míngtiān,hòutiān and dàhòutiān are used to express today,tomorrow,the day after tomorrow,and the fourth day fromnow.jǐ(how many)is a character used in questioning the number from two to nine.If one asks the number above nine,then shí(ten),bǎi

  19. Bootstrapping Time Dilation Decoherence

    CERN Document Server

    Gooding, Cisco

    2015-01-01

    We present a general relativistic model of a spherical shell of matter with a perfect fluid on its surface coupled to an internal oscillator, which generalizes a model recently introduced by the authors to construct a self-gravitating interferometer [1]. The internal oscillator evolution is defined with respect to the local proper time of the shell, allowing the oscillator to serve as a local clock that ticks differently depending on the shell's position and momentum. A Hamiltonian reduction is performed on the system, and an approximate quantum description is given to the reduced phase space. If we focus only on the external dynamics, we must trace out the clock degree of freedom, and this results in a form of intrinsic decoherence that shares some features with a proposed "universal" decoherence mechanism attributed to gravitational time dilation [2]. We show that the proposed decoherence remains present in the (gravity-free) limit of flat spacetime, indicating that the effect can be attributed entirely to ...

  20. The little book of time

    CERN Document Server

    Mainzer, Klaus

    2002-01-01

    chapter 1 Time in the Classical and Medieval Worldviews From the Beginnings to the Pre-Socratic School Zeno's Time Arrow and Aristotle's Continuum 6 Time and Creation According to Saint Augustine 15 Time and Medieval Astronomy 18 20 Calendars and Clocks chapter 2 Time in the Worldview of Classical Physics 25 Absolute Time According to Newton 26 Relational Time According to Leibniz 30 Time in Classical Mechanics 31 Time in Kant's Epistemology 35 chapter 3 Relativistic Spacetime 43 Time in Special Relativity Theory 44 Time in General Relativity Theory 50 Time in Relativistic Cosmology 54 chapter 4 Time and the Quantum World 61 Time in Quantum Mechanics 62 Time in Quantum Field Theories 70 Time, Black Holes, and the Anthropic Principle 78 Time and Thermodynamics chapter 5 83 Time in Equilibrium Thermodynamics 84 Time in Nonequilibrium Thermodynamics 2 9 Time, Irreversibility, and Self-Organization 100 chapter 6 Time and Life 107 Time in Darwin's Theory of Evolution 108 Time in Molecular Evolution 111 Time Hierar...

  1. Timing is everything :

    Energy Technology Data Exchange (ETDEWEB)

    Kobos, Peter Holmes; Walker, La Tonya Nicole; Malczynski, Leonard A.

    2013-10-01

    People save for retirement throughout their career because it is virtually impossible to save all youll need in retirement the year before you retire. Similarly, without installing incremental amounts of clean fossil, renewable or transformative energy technologies throughout the coming decades, a radical and immediate change will be near impossible the year before a policy goal is set to be in place. Therefore, our research question is, To meet our desired technical and policy goals, what are the factors that affect the rate we must install technology to achieve these goals in the coming decades? Existing models do not include full regulatory constraints due to their often complex, and inflexible approaches to solve for optimal engineering instead of robust and multidisciplinary solutions. This project outlines the theory and then develops an applied software tool to model the laboratory-to-market transition using the traditional technology readiness level (TRL) framework, but develops subsequent and a novel regulatory readiness level (RRL) and market readiness level (MRL). This tool uses the ideally-suited system dynamics framework to incorporate feedbacks and time delays. Future energy-economic-environment models, regardless of their programming platform, may adapt this software model component framework or module to further vet the likelihood of new or innovative technology moving through the laboratory, regulatory and market space. The prototype analytical framework and tool, called the Technology, Regulatory and Market Readiness Level simulation model (TRMsim) illustrates the interaction between technology research, application, policy and market dynamics as they relate to a new or innovative technology moving from the theoretical stage to full market deployment. The initial results that illustrate the models capabilities indicate for a hypothetical technology, that increasing the

  2. Time well spent

    DEFF Research Database (Denmark)

    Fallesen, Peter

    2013-01-01

    Individuals who spent time in foster care as children fare on average worse than non-placed peers in early adult life. Recent research on the effect of foster care placement on early adult life outcomes provides mixed evidence. Some studies suggest negative effects of foster care placement on early...... adult outcomes, others find null effects. This study shows that differences in the average duration of foster care stays explain parts of these discordant findings and then test how foster care duration shapes later life outcomes using administrative data on 7 220 children. The children experienced...... different average durations of foster care because of differences in exposure to a reform. Later born cohorts spent on average 3 months longer in foster care than earlier born cohorts. Isolating exogenous variation in duration of foster care, the study finds positive effects of increased duration of foster...

  3. Ideologies of Time

    DEFF Research Database (Denmark)

    Berg Johansen, Christina; De Cock, Christian

    2017-01-01

    Our article deals with how elite corporate actors in a Western capitalist-democratic society conceive of and prepare for the future. Paying attention to how senior officers of 10 important Danish companies make sense of the future will help us to identify how particular temporal narratives...... are ideologically marked. This ideological dimension offers a common sense frame that is structured around a perceived inevitability of capitalism, a market economy as the basic organizational structure of the social and economic order, and an assumption of confident access to the future. Managers envisage...... their organization’s future and make plans for organizational action in a space where ‘business as usual’ reigns, and there is little engagement with the future as fundamentally open – as a time-yet-to-come. In using a conceptual lens inspired by the work of Fredric Jameson, we first explore the details...

  4. Student progression on time

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise

    The paper discusses and problematizes the ways, in which recent Danish university reform challenges the ideals of the ‘Nordic model’. The aim of the so-called ‘speed-up’ reform (in Danish ‘studiefremdriftsreformen’) is to cut the time available for students to complete their university studies....... Starting in mid 2014 students will be obliged to sign up for exams for at least 60 ECTS a year. If a student flunks or in other ways gets more than 30 ECTS delayed, the state grants will stop until the student has regained the missing ECTS. Simultaneously, we see a major change in what is meant...... by flexibility. Before the reform, the system was increasingly required to facilitate transfer of credits and make it easier for students to compose more personalized learning portfolios, which can include courses from different institutions and study programmes. The latter is very much in line with the ideas...

  5. In times of change

    DEFF Research Database (Denmark)

    Poulsen, Signe; Ipsen, Christine

    2017-01-01

    Organizations develop and adapt to societal changes and technological developments, where one consequence is that dispersed workers are more common than never before. It is difficult to ensure employee wellbeing and performance, when separating managers from employees by either time or geography....... This paper explores the wellbeing of employees doing distance work, and examines the practices of the distance manager aimed at ensuring employee wellbeing and organizational performance. The pilot study use a case study approach in four organizations with qualitative interviews of distance managers....... The analysis of distance managers’ practices showed that they used both activities and capabilities in order to ensure employee wellbeing and organizational performance. The activities included planning, newsletters, and surveys, and the capabilities were to listen, create and show trust, and give authority...

  6. High Time Resolution Astrophysics

    CERN Document Server

    Phelan, Don; Shearer, Andrew

    2008-01-01

    High Time Resolution Astrophysics (HTRA) is an important new window to the universe and a vital tool in understanding a range of phenomena from diverse objects and radiative processes. This importance is demonstrated in this volume with the description of a number of topics in astrophysics, including quantum optics, cataclysmic variables, pulsars, X-ray binaries and stellar pulsations to name a few. Underlining this science foundation, technological developments in both instrumentation and detectors are described. These instruments and detectors combined cover a wide range of timescales and can measure fluxes, spectra and polarisation. These advances make it possible for HTRA to make a big contribution to our understanding of the Universe in the next decade.

  7. Extending over time

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel; Christensen, Marie Herget

    Studies of general extenders (GEs), such as Eng. and stuff like that, or something, typically find that it is a feature of youth speech, sometimes correlated with sex and class (e.g. Dubois 1992, Stubbe and Holmes 1995, Cheshire 2007, Tagliamonte and Denis 2010, Pichler and Levey 2011), but only...... that variants with sådan noget, though prevalent across the board, may be stigmatized, since they are produced mainly by young WC males, and exhibit an overall drop in frequency over time. In our paper, we will use GEs in Danish as a case study for evaluating prevailing assumptions about the relationship...... few have a design enabling them to distinguish unequivocally between age grading and communal change. In this paper, we present the results of a large-scale study of GEs in Danish, based on Copenhagen data from the LANCHART corpus, encompassing speech from three age cohorts, of which two have been...

  8. Student progression on time

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise

    The paper discusses and problematizes the ways, in which recent Danish university reform challenges the ideals of the ‘Nordic model’. The aim of the so-called ‘speed-up’ reform (in Danish ‘studiefremdriftsreformen’) is to cut the time available for students to complete their university studies...... by flexibility. Before the reform, the system was increasingly required to facilitate transfer of credits and make it easier for students to compose more personalized learning portfolios, which can include courses from different institutions and study programmes. The latter is very much in line with the ideas....... Starting in mid 2014 students will be obliged to sign up for exams for at least 60 ECTS a year. If a student flunks or in other ways gets more than 30 ECTS delayed, the state grants will stop until the student has regained the missing ECTS. Simultaneously, we see a major change in what is meant...

  9. Intrinsic Time Quantum Gravity

    CERN Document Server

    Yu, Hoi Lai

    2016-01-01

    Correct identification of the true gauge symmetry of General Relativity being 3d spatial diffeomorphism invariant(3dDI) (not the conventional infinite tensor product group with principle fibre bundle structure), together with intrinsic time extracted from clean decomposition of the canonical structure yields a self-consistent theory of quantum gravity. A new set of fundamental commutation relations is also presented. The basic variables are the eight components of the unimodular part of the spatial dreibein and eight SU(3) generators which correspond to Klauder's momentric variables that characterize a free theory of quantum gravity. The commutation relations are not canonical, but have well defined group theoretical meanings. All fundamental entities are dimensionless; and the quantum wave functionals are preferentially in the dreibein representation. The successful quantum theory of gravity involves only broad spectrum of knowledge and deep insights but no exotic idea.

  10. Solar wind travel time

    Science.gov (United States)

    Russell, C. T.

    A useful rule of thumb in solar terrestrial studies is that the solar wind travels 4 Earth radii (RE) per minute. Long-term studies of solar wind velocity [e.g., Luhmann et al., 1993; 1994] show that the median velocity is about 420 km/s, corresponding to 3.96 RE min-1. The quartiles are about 370 km/s and 495 km/s, corresponding to 3.48 Re min-1 and 4.66 Re min-1 respectively. This number helps estimate the delays expected when observing a discontinuity at a solar wind monitor; one example is ISEE-3 when it was at the forward libration point (about 60 min). It is also helpful for estimating how much time passes before the dayside magnetosphere is compressed as denser solar wind flows by (about 2.5 min).

  11. Funding Full-Time Study through Part-Time Work

    Science.gov (United States)

    Richardson, Mark; Evans, Carl; Gbadamosi, Gbolahan

    2009-01-01

    Full-time students engaged in part-time studies have been a subject of increasing academic attention. This study extends work in this area by examining: the extent to which full-time undergraduate students undertake part-time employment, the reasons for working whilst studying full-time and the extent to which students relate their part-time…

  12. Antimatter and Time-Symmetry

    CERN Document Server

    Pitts, T

    1998-01-01

    This theory makes time symmetric by Weyl's definition; it hypothesizes that space, time and mass-energy expand outward from the Big Bang along the time axis equally in the (+-) and (-) directions. In the Feynman-Stueckelberg Interpretation, antimatter is identical to matter but moves backward in time. This essay argues that this interpretation is physically real via an analysis of the time-symmetry of the Schrodinger equation. As time expands from zero, in both directions in time away from the origin, quantum uncertainty allows a brief, decreasing leakage of mass between (+-) and (-) universes. Matter leaking from (-) to (+-) time moves forward in time, producing a preponderance of matter in (+-) time. Antimatter leakage from (+-) time to (-) time in the same way produces an antimatter preponderance in the (-) time universe. The remaining opposite particles left behind after the leakage, (antimatter and matter respectively) proceeding outward in antitime and time respectively, after many annihilations also in...

  13. Reorganising space and time:

    Directory of Open Access Journals (Sweden)

    Nicolas Senil

    2011-07-01

    Full Text Available The multiplication of objects, actors and underlying rationales of heritage development, or patrimonialisation, is increasingly blurring the strength and meaning of our relationship with the past. The aim of this article is to reflect on the processes involved in the emergence of new heritage objects and on the consequences of these developments. The article is based on a comparative analysis of two symmetric objects, both of which have been the subject of heritage development processes: the Chauvet cave and the Millau viaduct in Southern France. By showing that each object is projected in the spatial or temporal dimension from which it was a priori excluded at the time of its discovery, the analysis demonstrates the necessity of integrating a heritage approach to our understanding of territorial dynamics. The analysis suggests that the interplay of territorialisation and heritage development processes represents a reconstruction of a controlled time-space, a prerequisite for addressing a recurring problem in our society, that of its sustainability.La multiplication des objets, des acteurs et des logiques de la patrimonialisation génère un brouillage de plus en plus important sur la force et le sens de nos rapports au passé. Dans ce contexte, cet article se propose de réfléchir aux processus d’émergence de nouveaux objets patrimoniaux et aux conséquences de ces mobilisations. Il s’appuie sur l’analyse comparée de deux objets symétriques et tous deux patrimonialisés : la grotte Chauvet et le viaduc de Millau. En montrant que chaque objet est projeté dans la dimension spatiale ou temporelle dont il se trouve a priori exclu lors de son invention, l’analyse rappelle la nécessité d’intégrer une approche patrimoniale à notre lecture des dynamiques territoriales. Elle propose alors l’idée que ces mouvements croisés représentent une reconstruction d’un espace-temps maitrisé, nécessaire pour répondre au probl

  14. Reconstruction of time-delay systems from chaotic time series.

    Science.gov (United States)

    Bezruchko, B P; Karavaev, A S; Ponomarenko, V I; Prokhorov, M D

    2001-11-01

    We propose a method that allows one to estimate the parameters of model scalar time-delay differential equations from time series. The method is based on a statistical analysis of time intervals between extrema in the time series. We verify our method by using it for the reconstruction of time-delay differential equations from their chaotic solutions and for modeling experimental systems with delay-induced dynamics from their chaotic time series.

  15. Time-independent wormholes

    Science.gov (United States)

    Fu, Zicao; Marolf, Donald; Mefford, Eric

    2016-12-01

    We study two-sided static wormholes with an exact Killing symmetry that translates both mouths of the wormhole toward the future. This differs from the familiar Kruskal wormhole whose time translation is future-directed only in one asymptotic region and is instead past-directed in the other. Our spacetimes are solutions to Einstein-Hilbert gravity sourced by scalar domain walls. Explicit examples are found in the thin wall approimation. More generally, we show that such spacetimes can arise in the presence of scalar fields with potentials that are C 1 but not C 2 and find examples numerically. However, solutions with an exact such Killing symmetry are forbidden when the scalar potential is smooth. Finally, we consider the mutual information of boundary regions associated with such wormholes in AdS/CFT. Although the interior of our solutions are unstable, we find that even mutual informations between opposite boundaries are already thermalized at any finite t in the sense that they agree with the t → ∞ limit of results from the familiar AdS-Kruskal solution.

  16. Time-independent wormholes

    CERN Document Server

    Fu, Zicao; Mefford, Eric

    2016-01-01

    We study two-sided static wormholes with an exact Killing symmetry that translates both mouths of the wormhole toward the future. This differs from the familiar Kruskal wormhole whose time translation is future-directed only in one asymptotic region and is instead past-directed in the other. Our spacetimes are solutions to Einstein-Hilbert gravity sourced by scalar domain walls. Explicit examples are found in the thin wall approximation. More generally, we show that such spacetimes can arise in the presence of scalar fields with potentials that are $C^1$ but not $C^2$ and find examples numerically. However, solutions with an exact such Killing symmetry are forbidden when the scalar potential is smooth. Finally, we consider the mutual information of boundary regions associated with such wormholes in AdS/CFT. Although the interior of our solutions are unstable, we find that even mutual informations between opposite boundaries are already thermalized at any finite $t$ in the sense that they agree with the $t\\rig...

  17. Time to gather stones…

    Directory of Open Access Journals (Sweden)

    Elena Lyudvigovna Yakovleva

    2015-03-01

    Full Text Available Objective to search for ways of further development of modern Russia affected by sanctions. Methods dialectical method of cognition of the solitude phenomenon metaphorically transferred from personality to the image of Russia phenomenological method establishing a positive diversity solitude states futurological forecasting method by which the Russia development trends are visualized. Results the situation of the Russian society which appeared in solitude is not a reason for pessimism. This is positive time for reflection on the situation and correcting the errors there is a possibility to recover the Russian identity to form the image of Motherland and inclusive existence based on the culture of partnership and solidarity. Scientific novelty the analysis of the solitude state allows to detect its positive potential associated with correction of errors restoration of the image of Motherland and formation of identity. So that their effectiveness had a lasting effect it is necessary to pay attention to the inclusive education system which brings up a personality included into existence. Practical value the main provisions and conclusions of the article can be used in scientific educational and practical activities in the review and analysis of the state of modern Russian society under sanctions. nbsp

  18. Time-independent wormholes

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Zicao; Marolf, Donald; Mefford, Eric [Department of Physics, University of California,Santa Barbara, CA 93106 (United States)

    2016-12-06

    We study two-sided static wormholes with an exact Killing symmetry that translates both mouths of the wormhole toward the future. This differs from the familiar Kruskal wormhole whose time translation is future-directed only in one asymptotic region and is instead past-directed in the other. Our spacetimes are solutions to Einstein-Hilbert gravity sourced by scalar domain walls. Explicit examples are found in the thin wall approimation. More generally, we show that such spacetimes can arise in the presence of scalar fields with potentials that are C{sup 1} but not C{sup 2} and find examples numerically. However, solutions with an exact such Killing symmetry are forbidden when the scalar potential is smooth. Finally, we consider the mutual information of boundary regions associated with such wormholes in AdS/CFT. Although the interior of our solutions are unstable, we find that even mutual informations between opposite boundaries are already thermalized at any finite t in the sense that they agree with the t→∞ limit of results from the familiar AdS-Kruskal solution.

  19. Time, Quantum and Information

    Energy Technology Data Exchange (ETDEWEB)

    Turner, Leaf [Los Alamos, New Mexico (United States)

    2004-04-09

    Time, Quantum and Information, a paean to Professor Carl Friedrich von Weizsaecker, commemorates his 90th birthday. The range of Professor Weizsaecker's endeavours is an exhilarating example of what can be accomplished by one freely-soaring human spirit, who is at the same time a physicist, a philosopher, and a humanitarian. The editors, Lutz Castell and Otfried Ischebeck, have assembled an admirable collection of essays and articles written by Weizsaecker?s past students, collaborators, colleagues and acquaintances. Time, Quantum and Information offers the reader a panoply of unique insights into twentieth century science and history. Entangled with the stories about Weizsaecker?s influence on the lives of some of the contributors are discussions of the activities of German scientists during and following World War II, emphasizing their reluctance to work on atomic weapons following the war. By outlining Weizsaecker?s role in the early development of numerous tributaries of physical science, the book gives us a new glimpse into the origins of some of its disparate domains, such as nuclear physics, the physics of stellar nucleosynthesis, cosmic ray physics, fluid turbulence, and the formation of the solar system. We physicists have all studied Weizsaecker?s semi-empirical mass formula describing the binding energy of nuclei. We are aware too that both he and Hans Bethe independently discovered the nuclear cycles that provide stars with their enduring energy output. We have studied the Weizsaecker--Williams technique of calculating the bremsstrahlung of relativistic electrons. But how many of us know of Weizsaecker's work in fluid turbulence that he, like Werner Heisenberg under whom he had earned his doctorate, pursued while holed up in Farm Hall? And how many of us are aware of his introduction of turbulent viscosity to account for the origin of planetary orbits, involving the migration of mass inwards and angular momentum outwards? Moreover, before

  20. Distance, Borders, and Time

    DEFF Research Database (Denmark)

    Skillicorn, David; Walther, Olivier; Zheng, Quan

    This paper explores the spatial and temporal diffusion of political violence in North and West Africa. It does so by endeavoring to represent the mental landscape that lives in the back of a group leader’s mind as he contemplates strategic targeting. We assume that this representation is a combin......This paper explores the spatial and temporal diffusion of political violence in North and West Africa. It does so by endeavoring to represent the mental landscape that lives in the back of a group leader’s mind as he contemplates strategic targeting. We assume that this representation...... constrains a group leader to attack at a location other than the one that would seem to yield the greatest overt payoff. By its very nature, the research problem defies the collection of a full set of structural data. Instead, we leverage functional data from the Armed Conflict Location and Event Data......” of North and West Africa that depicts the permeability to violence. A better understanding of how location, time, and borders condition attacks enables planning, prepositioning, and response....

  1. Aid Supplies Over Time

    DEFF Research Database (Denmark)

    Jones, Edward Samuel

    The recent financial crisis has rekindled interest in the foreign aid supply behaviour of bilateral donors. Using the latest data covering the period 1960-2009, this paper examines how such behaviour is related to domestic factors. Based on a simple empirical model, a distinction is made between ...... substantial heterogeneity between countries. There is also good evidence that donor behaviour continues to evolve over time. As such, past trends in aid supplies are unlikely to provide a good guide to those of the future.......The recent financial crisis has rekindled interest in the foreign aid supply behaviour of bilateral donors. Using the latest data covering the period 1960-2009, this paper examines how such behaviour is related to domestic factors. Based on a simple empirical model, a distinction is made between...... long-run supply trends and short-run dynamics, which motivates use of error correction methods. Panel econometric techniques are employed that are consistent in the presence of parameter heterogeneity and cross-section dependence. Results support the error correction framework, but point to very...

  2. It's time for psychoneuroimmunology.

    Science.gov (United States)

    Kelley, K W

    2001-03-01

    It is intuitively obvious that the mind and the body are joined in ways that are not yet understood. The mission of the PsychoNeuroImmunology Research Society (PNIRS) is to delineate these relationships, to try to understand their connections at the molecular level and to use this knowledge to prevent and relieve human pain and suffering. Members of our Society have already made substantial and important contributions toward accomplishing these goals. For example, regulation of the neuroendocrine system by proinflammatory cytokines and development of the concept of sickness behavior have now become established and well-accepted tenets in psychoneuroimmunology. Although we possess some of the research tools that are needed to accomplish our goals, we need more. We must continue to apply new information that is constantly being generated in the biological sciences, such as what may be found in the recently completed mapping and sequencing of the human genome. There will always be fundamental discoveries that can and should be used to advance the field of psychoneuroimmunology and to help us accomplish our mission. Our research is needed to minimize human afflictions and to learn how patients can better participate in their own health management. That is why the time for psychoneuroimmunology is now.

  3. Mixing times are hitting times of large sets

    CERN Document Server

    Peres, Yuval

    2011-01-01

    We consider irreducible reversible discrete time Markov chains on a finite state space. Mixing times and hitting times are fundamental parameters of the chain. We relate them by showing that the mixing time of the lazy chain is equivalent to the maximum over initial states $x$ and large sets $A$ of the hitting time of $A$ starting from $x$. We also prove that the first time when averaging over two consecutive time steps is close to stationarity is equivalent to the mixing time of the lazy version of the chain.

  4. MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

    Science.gov (United States)

    Kao, W H Linda; Klag, Michael J; Meoni, Lucy A; Reich, David; Berthier-Schaad, Yvette; Li, Man; Coresh, Josef; Patterson, Nick; Tandon, Arti; Powe, Neil R; Fink, Nancy E; Sadler, John H; Weir, Matthew R; Abboud, Hanna E; Adler, Sharon G; Divers, Jasmin; Iyengar, Sudha K; Freedman, Barry I; Kimmel, Paul L; Knowler, William C; Kohn, Orly F; Kramp, Kristopher; Leehey, David J; Nicholas, Susanne B; Pahl, Madeleine V; Schelling, Jeffrey R; Sedor, John R; Thornley-Brown, Denyse; Winkler, Cheryl A; Smith, Michael W; Parekh, Rulan S

    2008-10-01

    As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.

  5. A genome-wide admixture scan identifies MYH9 as a candidate locus associated with non-diabetic end stage renal disease in African Americans

    Science.gov (United States)

    Linda Kao, WH; Klag, Michael J; Meoni, Lucy A; Reich, David; Berthier-Schaad, Yvette; Li, Man; Coresh, Josef; Patterson, Nick; Tandon, Arti; Powe, Neil R; Fink, Nancy E; Sadler, John H; Weir, Matthew R; Abboud, Hanna E; Adler, Sharon; Divers, Jasmin; Iyengar, Sudha K; Freedman, Barry I; Kimmel, Paul L; Knowler, William C; Kohn, Orly F; Kramp, Kristopher; Leehey, David J; Nicholas, Susanne; Pahl, Madeleine; Schelling, Jeffrey R; Sedor, John R; Thornley-Brown, Denyse; Winkler, Cheryl A; Smith, Michael W.; Parekh, Rulan S.

    2008-01-01

    End stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans. This led to the hypothesis that susceptibility alleles for ESRD have a higher frequency in West African than European gene pool. We performed a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and demonstrated a highly significant association between excess African ancestry and non-diabetic ESRD (LOD 5.70) but not diabetic ESRD (LOD 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% credible interval 0.39 – 0.63) compared to African ancestry. Multiple common SNPs (allele frequency ranging from 0.2 to 0.6) in the gene that encodes non-muscle myosin heavy chain type II isoform A (MYH9) were associated with 2-4 times greater risk of non-diabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans. PMID:18794854

  6. SLH Timing Belt Powertrain

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Abe

    2014-04-09

    The main goal of this proposal was to develop and test a novel powertrain solution for the SLH hydroEngine, a low-cost, efficient low-head hydropower technology. Nearly two-thirds of U.S. renewable electricity is produced by hydropower (EIA 2010). According to the U.S. Department of Energy; this amount could be increased by 50% with small hydropower plants, often using already-existing dams (Hall 2004). There are more than 80,000 existing dams, and of these, less than 4% generate power (Blankinship 2009). In addition, there are over 800 irrigation districts in the U.S., many with multiple, non-power, low-head drops. These existing, non-power dams and irrigation drops could be retrofitted to produce distributed, baseload, renewable energy with appropriate technology. The problem is that most existing dams are low-head, or less than 30 feet in height (Ragon 2009). Only about 2% of the available low-head hydropower resource in the U.S. has been developed, leaving more than 70 GW of annual mean potential low-head capacity untapped (Hall 2004). Natel Energy, Inc. is developing a low-head hydropower turbine that operates efficiently at heads less than 6 meters and is cost-effective for deployment across multiple low-head structures. Because of the unique racetrack-like path taken by the prime-movers in the SLH, a flexible powertrain is required. Historically, the only viable technological solution was roller chain. Despite the having the ability to easily attach blades, roller chain is characterized by significant drawbacks, including high cost, wear, and vibration from chordal action. Advanced carbon- fiber-reinforced timing belts have been recently developed which, coupled with a novel belt attachment system developed by Natel Energy, result in a large reduction in moving parts, reduced mass and cost, and elimination of chordal action for increased fatigue life. The work done in this project affirmatively addressed each of the following 3 major uncertainties concerning

  7. Time to talk condoms.

    Science.gov (United States)

    Piotrow, P T; Rinehart, W

    1991-09-01

    A great deal of avoided if political and religious leaders, educators, health care providers and the mass media would band together in an effort to promote condom use. Condoms use protects against unwanted pregnancies, STDs and AIDS. Yet, public discussions on condom use are rate. In the US, political leaders avoid mentioning the topic, and television networks severely restrict the airing of public service announcements for condoms. Worldwide, an estimated 100 billion acts of sexual intercourse take place every year. A recent report indicates that it would take a modest 13 billion condoms a year to protect everyone who is at risk of contracting AIDS and other STDs, and risk of having an unwanted pregnancy. Currently, worldwide production of condoms stands at about 6 billion a year. Furthermore, condom makers have the capacity to increase production by some 2 billion, and could add new capacity in about 2 years. Many believe that marketing condoms is a difficult enterprise, since men often report that condoms reduce pleasure, cause embarrassment, or are not available when needed. The challenge for markets, then, is to create demand. This is especially true in the US, where prime-time advertising and the use of popular entertainment, such as soap operas, could promote condoms as both safe and satisfying. In the developing world, the challenge is to make condoms widely available and affordable. Some changes have taken place since 1981, when AIDS first came into the spotlight. In the US, people now discuss the topic of STDs more openly. But an all-out effort to promote condom use has not yet begun.

  8. Fourteen Times the Earth

    Science.gov (United States)

    2004-08-01

    ESO HARPS Instrument Discovers Smallest Ever Extra-Solar Planet Summary A European team of astronomers [1] has discovered the lightest known planet orbiting a star other than the sun (an "exoplanet"). The new exoplanet orbits the bright star mu Arae located in the southern constellation of the Altar. It is the second planet discovered around this star and completes a full revolution in 9.5 days. With a mass of only 14 times the mass of the Earth, the new planet lies at the threshold of the largest possible rocky planets, making it a possible super Earth-like object. Uranus, the smallest of the giant planets of the Solar System has a similar mass. However Uranus and the new exoplanet differ so much by their distance from the host star that their formation and structure are likely to be very different. This discovery was made possible by the unprecedented accuracy of the HARPS spectrograph on ESO's 3.6-m telescope at La Silla, which allows radial velocities to be measured with a precision better than 1 m/s. It is another clear demonstration of the European leadership in the field of exoplanet research. PR Photo 25a/04: The HARPS Spectrograph and the 3.6m Telescope PR Photo 25b/04: Observed Velocity Variation of mu Arae (3.6m/HARPS, 1.2m Swiss/CORALIE, AAT/UCLES) PR Photo 25c/04: Velocity Variation of mu Arae Observed by HARPS (3.6m/HARPS) PR Photo 25d/04: "Velocity Curve" of mu Arae A unique planet hunting machine ESO PR Photo 25a/04 ESO PR Photo 25a/04 The HARPS Spectrograph and the 3.6m Telescope [Preview - JPEG: 602 x 400 pix - 211k] [Normal - JPEG: 1202 x 800 pix - 645k] Caption: ESO PR Photo 25a/04 represents a montage of the HARPS spectrograph and the 3.6m telescope at La Silla. The upper left shows the dome of the telescope, while the upper right illustrates the telescope itself. The HARPS spectrograph is shown in the lower image during laboratory tests. The vacuum tank is open so that some of the high-precision components inside can be seen. Since the first

  9. Response Features Determining Spike Times

    Directory of Open Access Journals (Sweden)

    Barry J. Richmond

    1999-01-01

    redundant with that carried by the coarse structure. Thus, the existence of precisely timed spike patterns carrying stimulus-related information does not imply control of spike timing at precise time scales.

  10. Management Styles and Techniques: Time.

    Science.gov (United States)

    Matthews, Priscilla J.

    1987-01-01

    Discusses strategies to improve individuals' use of time and personal satisfaction through time management. The 126-item bibliography includes citations for time management in general and special sections for career development, family and parenting, women, and home management. (CLB)

  11. Management Styles and Techniques: Time.

    Science.gov (United States)

    Matthews, Priscilla J.

    1987-01-01

    Discusses strategies to improve individuals' use of time and personal satisfaction through time management. The 126-item bibliography includes citations for time management in general and special sections for career development, family and parenting, women, and home management. (CLB)

  12. Recapturing time: a practical approach to time management for physicians.

    Science.gov (United States)

    Gordon, Craig E; Borkan, Steven C

    2014-05-01

    Increasing pressures on physicians demand effective time management and jeopardise professional satisfaction. Effective time management potentially increases productivity, promotes advancement, limits burnout and improves both professional and personal satisfaction. However, strategies for improving time management are lacking in the current medical literature. Adapting time management techniques from the medical and non-medical literature may improve physician time management habits. These techniques can be divided into four categories: (1) setting short and long-term goals; (2) setting priorities among competing responsibilities; (3) planning and organising activities; and (4) minimising 'time wasters'. Efforts to improve time management can increase physician productivity and enhance career satisfaction.

  13. Discovering timing feature interactions with timed UML 2 interactions

    DEFF Research Database (Denmark)

    Störrle, Harald; Knapp, Alexander

    2016-01-01

    patterns of timing specifications and show how they can be translated into UML 2 interactions with time constraints. We define a semantics that allows us to define and check coherence and consistency conditions of timing specifications. RESULTS: We provide a systematic process for mapping timing...... requirements into timed UML interactions and algorithms for checking their coherence and consistency. CONCLUSIONS: With our approach, it becomes easier to check and validate timing specifications. It is not our ambition to achieve complete coverage, i.e., discovering all timing specification defects. Instead...

  14. A comparative study of renal care in Brazil and Mexico: hemodialysis treatment from the perspective of ESRD sufferers.

    Science.gov (United States)

    Mercado-Martinez, Francisco J; da Silva, Denise Guerreiro V; Correa-Mauricio, Mauricio E

    2017-04-01

    Renal replacement therapy is the indicated treatment for individuals with chronic kidney disease (CKD) to survive. However, not all sick people have access to the same treatment. This study compares renal care in two developing countries with different health systems. Specifically, it explores hemodialysis treatment from the perspective of low-income individuals. A qualitative, comparative study was performed in Brazil and Mexico. Using purposive sampling, the research was based on open-ended interviews with nineteen participants with kidney failure undergoing hemodialysis treatment in public hospitals and ten relatives. According to our results, Brazilian participants perceived hemodialysis care as satisfactory because of health personnel courtesy as well as free access to dialysis treatment, prescription drugs, hospitalization and transportation. However, they reported deficiencies in the care they were receiving due to shortages of specialists, prescription drugs, laboratory tests and transportation. Mexican participants, in contrast, highlighted the catastrophic costs of medical care because they had no free access to renal therapy, nor adequate financial resources. Our findings suggest that low-income Brazilian CKD sufferers experience renal care differently, as they are more satisfied and face less obstacles with hemodialysis compared with those of Mexico. More studies on the topic are needed. © 2016 John Wiley & Sons Ltd.

  15. Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD

    DEFF Research Database (Denmark)

    Desai, Akshay S; Toto, Robert; Jarolim, Petr

    2011-01-01

    In patients with chronic kidney disease (CKD), as in other populations, elevations in cardiac biomarker levels predict increased risk of cardiovascular events. We examined the value of troponin T (TnT) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in assessing the risk of developing e...

  16. Tuberculosis in ancient times

    Directory of Open Access Journals (Sweden)

    Louise Cilliers

    2008-09-01

    Full Text Available In spite of an array of effective antibiotics, tuberculosis is still very common in developing countries where overcrowding, malnutrition and poor hygienic conditions prevail. Over the past 30 years associated HIV infection has worsened the situation by increasing the infection rate and mortality of tuberculosis. Of those diseases caused by a single organism only HIV causes more deaths internationally than tuberculosis. The tubercle bacillus probably first infected man in Neolithic times, and then via infected cattle, but the causative Mycobacteriacea have been in existence for 300 million years. Droplet infection is the most common way of acquiring tuberculosis, although ingestion (e.g. of infected cows’ milk may occur. Tuberculosis probably originated in Africa. The earliest path gnomonic evidence of human tuberculosis in man was found in osteo-archaeological findings of bone tuberculosis (Pott’s disease of the spine in the skeleton of anEgyptian priest from the 21st Dynasty (approximately 1 000 BC. Suggestive but not conclusiveevidence of tuberculotic lesions had been found in even earlier skeletons from Egypt and Europe. Medical hieroglyphics from ancient Egypt are silent on the disease, which could be tuberculosis,as do early Indian and Chinese writings. The Old Testament refers to the disease schachapeth, translated as phthisis in the Greek Septuagint. Although the Bible is not specific about this condition, tuberculosis is still called schachapeth in modern Hebrew. In pre-Hippocratic Greece Homer did not mention phthisis, a word meaning non-specific wasting of the body. However. Alexander of Tralles (6th century BC seemed to narrow the concept down to a specific disease, and in the Hippocratic Corpus (5th-4th centuries BC phthisis can be recognised as tuberculosis. It was predominantly a respiratory disease commonly seen and considered to be caused by an imbalance of bodily humours. It was commonest in autumn, winter and spring

  17. Tuberculosis in ancient times

    Directory of Open Access Journals (Sweden)

    Louise Cilliers

    2008-09-01

    Full Text Available In spite of an array of effective antibiotics, tuberculosis is still very common in developing countries where overcrowding, malnutrition and poor hygienic conditions prevail. Over the past 30 years associated HIV infection has worsened the situation by increasing the infection rate and mortality of tuberculosis. Of those diseases caused by a single organism only HIV causes more deaths internationally than tuberculosis. The tubercle bacillus probably first infected man in Neolithic times, and then via infected cattle, but the causative Mycobacteriacea have been in existence for 300 million years. Droplet infection is the most common way of acquiring tuberculosis, although ingestion (e.g. of infected cows’ milk may occur. Tuberculosis probably originated in Africa. The earliest path gnomonic evidence of human tuberculosis in man was found in osteo-archaeological findings of bone tuberculosis (Pott’s disease of the spine in the skeleton of anEgyptian priest from the 21st Dynasty (approximately 1 000 BC. Suggestive but not conclusiveevidence of tuberculotic lesions had been found in even earlier skeletons from Egypt and Europe. Medical hieroglyphics from ancient Egypt are silent on the disease, which could be tuberculosis,as do early Indian and Chinese writings. The Old Testament refers to the disease schachapeth, translated as phthisis in the Greek Septuagint. Although the Bible is not specific about this condition, tuberculosis is still called schachapeth in modern Hebrew. In pre-Hippocratic Greece Homer did not mention phthisis, a word meaning non-specific wasting of the body. However. Alexander of Tralles (6th century BC seemed to narrow the concept down to a specific disease, and in the Hippocratic Corpus (5th-4th centuries BC phthisis can be recognised as tuberculosis. It was predominantly a respiratory disease commonly seen and considered to be caused by an imbalance of bodily humours. It was commonest in autumn, winter and spring

  18. EDITORIAL: Interesting times

    Science.gov (United States)

    Dobson Honorary Editor, Ken

    1996-01-01

    `May you live in interesting times' - old Chinese curse. First, many thanks to John Avison, the retiring Honorary Editor, for his hard work over the last five years, and the steady development in style and content under his stewardship. I can only hope to live up to the standards that he set. The next five years will take us into a new millenium, an event preceded - in England and Wales at least - by a period of stability, reflection and consolidation in education. Or so we are told - but whether such a self-denying ordinance will actually be maintained by the Government both before and after an election in 1997 remains to be seen. Nevertheless, we shall be thankful for any mercies, however small, that permit forward thinking rather than instant response. One of the things that readers of a journal called Physics Education should be thinking about is the continued decline in the numbers of students studying physics post-16. This is not a purely local phenomenon; most European countries are finding a similar decline. There are exceptions, of course: in Scotland numbers studying physics for Highers are increasing. Is such a decline a good thing or a bad thing? Only a minority of post-16 physics students go on to use the bulk of what they have learned in further studies or vocations. Does a knowledge and understanding of physics contribute to the mental well-being and cultural level - let alone material comfort - of any except those who use physics professionally? Is physics defensible as a contribution to the mental armoury of the educated citizen - compared with chemistry, biology - or Latin, say? Or should one rephrase that last question as `Is physics as we teach it today defensible...?' Such questions, and many others no doubt, may well be in the mind of the new Curriculum Officer appointed by the Institute of Physics `to engage in a wide-ranging consultation throughout the entire physics community on the nature and style of post-16 physics programmes, with a

  19. How to Use Time Wisely

    Institute of Scientific and Technical Information of China (English)

    RobertE.Glenn; 沈畔阳

    2004-01-01

    Far too many students in school today cannot manage their time adequately. Since time management for students is a key component of effective study skills, a lot of students could learn more and make better grades if they managed time better. Below are important fundamentals of using time wisely.

  20. What is a Timing Anomaly?

    DEFF Research Database (Denmark)

    Cassez, Franck; Hansen, Rene Rydhof; Olesen, Mads Chr.

    2012-01-01

    Timing anomalies make worst-case execution time analysis much harder, because the analysis will have to consider all local choices. It has been widely recognised that certain hardware features are timing anomalous, while others are not. However, defining formally what a timing anomaly is, has bee...

  1. Time averaging, ageing and delay analysis of financial time series

    Science.gov (United States)

    Cherstvy, Andrey G.; Vinod, Deepak; Aghion, Erez; Chechkin, Aleksei V.; Metzler, Ralf

    2017-06-01

    We introduce three strategies for the analysis of financial time series based on time averaged observables. These comprise the time averaged mean squared displacement (MSD) as well as the ageing and delay time methods for varying fractions of the financial time series. We explore these concepts via statistical analysis of historic time series for several Dow Jones Industrial indices for the period from the 1960s to 2015. Remarkably, we discover a simple universal law for the delay time averaged MSD. The observed features of the financial time series dynamics agree well with our analytical results for the time averaged measurables for geometric Brownian motion, underlying the famed Black-Scholes-Merton model. The concepts we promote here are shown to be useful for financial data analysis and enable one to unveil new universal features of stock market dynamics.

  2. Time perception and time perspective differences between adolescents and adults.

    Science.gov (United States)

    Siu, Nicolson Y F; Lam, Heidi H Y; Le, Jacqueline J Y; Przepiorka, Aneta M

    2014-09-01

    The present experiment aimed to investigate the differences in time perception and time perspective between subjects representing two developmental stages, namely adolescence and middle adulthood. Twenty Chinese adolescents aged 15-25 and twenty Chinese adults aged 35-55 participated in the study. A time discrimination task and a time reproduction task were implemented to measure the accuracy of their time perception. The Zimbardo Time Perspective Inventory (Short-Form) was adopted to assess their time orientation. It was found that adolescents performed better than adults in both the time discrimination task and the time reproduction task. Adolescents were able to differentiate different time intervals with greater accuracy and reproduce the target duration more precisely. For the time reproduction task, it was also found that adults tended to overestimate the duration of the target stimuli while adolescents were more likely to underestimate it. As regards time perspective, adults were more future-oriented than adolescents, whereas adolescents were more present-oriented than adults. No significant relationship was found between time perspective and time perception.

  3. Neuropsychological deficits associated with uraemic encephalopathy

    African Journals Online (AJOL)

    (ESRD) often present with impaired cognitive functions, little information exists concerning ... during conditions of time-pressure); (i/) deficit in attentional processes .... behaviour is functional or psychoneurological in origin), which could have ...

  4. Playing Games with Timed Games

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Chatain, Thomas

    2009-01-01

    In this paper we focus on property-preserving preorders between timed game automata and their application to control of partially observable systems. Following the example of timed simulation between timed automata, we define timed alternating simulation as a preorder between timed game automata......, which preserves controllability. We define a method to reduce the timed alternating simulation problem to a safety game. We show how timed alternating simulation can be used to control efficiently a partially observable system. This method is illustrated by a generic case study....

  5. Introducing time a graphic guide

    CERN Document Server

    Callender, Craig

    2010-01-01

    What is time? The 5th-century philosopher St Augustine famously said that he knew what time was, so long as no one asked him. Is time a fourth dimension similar to space or does it flow in some sense? And if it flows, does it make sense to say how fast? Does the future exist? Is time travel possible? Why does time seem to pass in only one direction?These questions and others are among the deepest and most subtle that one can ask, but "Introducing Time" presents them - many for the first time - in an easily accessible, lucid and engaging manner, wittily illustrated by Ralph Edney.

  6. Playing Games with Timed Games

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Chatain, Thomas

    2009-01-01

    In this paper we focus on property-preserving preorders between timed game automata and their application to control of partially observable systems. Following the example of timed simulation between timed automata, we define timed alternating simulation as a preorder between timed game automata......, which preserves controllability. We define a method to reduce the timed alternating simulation problem to a safety game. We show how timed alternating simulation can be used to control efficiently a partially observable system. This method is illustrated by a generic case study....

  7. Cancer survivors' experience of time

    DEFF Research Database (Denmark)

    Rasmussen, Dorte M.; Elverdam, Beth

    2007-01-01

    time and life; (2) awareness of time increases, time is verbalized and reflected; and (3) the informants appropriate time. A diagnosis of cancer, even for a survivor, means a confrontation with death. It means a disruption of continuous clock and calendar time. Survivors appropriate time...... and ethnographic interviews with 23 informants. Ten men and 13 women were interviewed twice: 2 weeks after their stay and 18 months later. FINDINGS: Data were analysed from a culture-analytical perspective. Three main themes regarding the survivors' handling and perception of time were found: (1) cancer disrupts...

  8. Computer network time synchronization the network time protocol

    CERN Document Server

    Mills, David L

    2006-01-01

    What started with the sundial has, thus far, been refined to a level of precision based on atomic resonance: Time. Our obsession with time is evident in this continued scaling down to nanosecond resolution and beyond. But this obsession is not without warrant. Precision and time synchronization are critical in many applications, such as air traffic control and stock trading, and pose complex and important challenges in modern information networks.Penned by David L. Mills, the original developer of the Network Time Protocol (NTP), Computer Network Time Synchronization: The Network Time Protocol

  9. Timed arrays wideband and time varying antenna arrays

    CERN Document Server

    Haupt, Randy L

    2015-01-01

    Introduces timed arrays and design approaches to meet the new high performance standards The author concentrates on any aspect of an antenna array that must be viewed from a time perspective. The first chapters briefly introduce antenna arrays and explain the difference between phased and timed arrays. Since timed arrays are designed for realistic time-varying signals and scenarios, the book also reviews wideband signals, baseband and passband RF signals, polarization and signal bandwidth. Other topics covered include time domain, mutual coupling, wideband elements, and dispersion. The auth

  10. Timing and time signal distribution in digital communications networks

    Science.gov (United States)

    Kihara, Masami; Imaoka, Atushi

    1992-06-01

    The timing signal distribution characteristics of a digital communications network are evaluated to determine the Maximum Time Interval Error (MTIE) of the network; reference is made to the performance of network components such as transmission systems, slave clocks and timing distribution systems in intraoffices. The MTIE of each component is measured and used to determine the allowable MTIE of that component. The maximum number of slave node chains is shown to be 20. Time signal distribution performance is detailed. It is shown that time synchronization accuracy is of the order of submicroseconds between nodes separated by 2400 km over a two year period. For intra-office time signal distribution, the relative time accuracy is less than 3 nanoseconds using an 8 Mb/s round trip digital interface to connect a time signal supply in an office to dispersed equipment.

  11. Timing intervals using population synchrony and spike timing dependent plasticity

    Directory of Open Access Journals (Sweden)

    Wei Xu

    2016-12-01

    Full Text Available We present a computational model by which ensembles of regularly spiking neurons can encode different time intervals through synchronous firing. We show that a neuron responding to a large population of convergent inputs has the potential to learn to produce an appropriately-timed output via spike-time dependent plasticity. We explain why temporal variability of this population synchrony increases with increasing time intervals. We also show that the scalar property of timing and its violation at short intervals can be explained by the spike-wise accumulation of jitter in the inter-spike intervals of timing neurons. We explore how the challenge of encoding longer time intervals can be overcome and conclude that this may involve a switch to a different population of neurons with lower firing rate, with the added effect of producing an earlier bias in response. Experimental data on human timing performance show features in agreement with the model’s output.

  12. The personal experience of time

    CERN Document Server

    Wessman, Alden

    1977-01-01

    The fundamental nature of human time experience has concerned artists, poets, philosophers, and scientists throughout the ages. Any consideration of human action requires awareness of its temporal aspects. However, simply to view time in the same units and dimensions as the physicist employs in describing events robs personal time of its "lived" quality. The use of physical time concepts in the description of human events is often artificial and misleading. It fails to account for the facts that human time estimates rarely match clock and calendar time; that societies and individuals demonstrate vast differences in their constructions and uses of time; and that temporal perceptions and attitudes change within an individual both during a single day and throughout his life span. The present volume does not view time as something that is sensed in the same way that one would sense or perceive spatial or sensory stimuli. Rather, it views time as a complex set of personally experienced cognitive constructs used by...

  13. total completion time with random and bounded setup times

    Directory of Open Access Journals (Sweden)

    Ali Allahverdi

    2003-01-01

    Full Text Available This paper addresses the two-machine flowshop scheduling problem with separate setup times to minimize makespan or total completion time (TCT. Setup times are relaxed to be random variables rather than deterministic as commonly used in the OR literature. Moreover, distribution-free setup times are used where only the lower and upper bounds are given. Global and local dominance relations are developed for the considered flowshops and an illustrative numerical example is given.

  14. Time concurrency/phase-time synchronization in digital communications networks

    Science.gov (United States)

    Kihara, Masami; Imaoka, Atsushi

    1990-01-01

    Digital communications networks have the intrinsic capability of time synchronization which makes it possible for networks to supply time signals to some applications and services. A practical estimation method for the time concurrency on terrestrial networks is presented. By using this method, time concurrency capability of the Nippon Telegraph and Telephone Corporation (NTT) digital communications network is estimated to be better than 300 ns rms at an advanced level, and 20 ns rms at final level.

  15. Time-Rich and Time-Poor Consumer Behavior the Importance of Time in Market Segmention

    OpenAIRE

    Lindskog, Helena; Brege, Staffan

    2002-01-01

    Some individuals and families are time-rich and others are time-poor. The degree of time-poverty or richness is more or less objectively or subjectively experienced. Therefore, time is an important variable in market segmentation for defining the customer target groups, developing products and services and building the most efficient marketing channels.

  16. Real time process algebra with time-dependent conditions

    NARCIS (Netherlands)

    Baeten, J.C.M.; Middelburg, C.A.

    2000-01-01

    We extend the main real time version of ACP presented in [6] with conditionals in which the condition depends on time. This extension facilitates flexible dependence of proccess behaviour on initialization time. We show that the conditions concerned generalize the conditions introduced earlier in a

  17. Real time process algebra with time-dependent conditions

    NARCIS (Netherlands)

    Baeten, J.C.M.; Middelburg, C.A.

    2008-01-01

    We extend the main real time version of ACP presented in [6] with conditionals in which the condition depends on time. This extension facilitates flexible dependence of proccess behaviour on initialization time. We show that the conditions concerned generalize the conditions introduced earlier in a

  18. Timed-Arc Petri Nets vs. Networks of Timed Automata

    DEFF Research Database (Denmark)

    Srba, Jiri

    requirement and provide efficient (polynomial time) reductions between networks of timed automata and 1-safe timed-arc Petri nets preserving the answer to the reachability question. This makes our techniques suitable for automatic translation into a format required by tools like UPPAAL and KRONOS. A direct...

  19. Real time process algebra with time-dependent conditions

    NARCIS (Netherlands)

    Baeten, J.C.M.; Middelburg, C.A.

    We extend the main real time version of ACP presented in [6] with conditionals in which the condition depends on time. This extension facilitates flexible dependence of proccess behaviour on initialization time. We show that the conditions concerned generalize the conditions introduced earlier

  20. GRAB for Time: A Time Management Skills Board Game.

    Science.gov (United States)

    Kirk, James; Patterson, Aimee; Woody, Connie; Lewis, Kathy; Cook, Marian; Duckett, Steve

    In addition to a brief introduction to time management, this document contains a training manual for teaching time management skills to workers at all levels in an organization. The training is offered in the form of a board game that takes approximately 1-1/2 to 2 hours to play. Among the time management principles learned in the game are…

  1. Time Evolution in Dynamical Spacetimes

    CERN Document Server

    Tiemblo, A

    1996-01-01

    We present a gauge--theoretical derivation of the notion of time, suitable to describe the Hamiltonian time evolution of gravitational systems. It is based on a nonlinear coset realization of the Poincaré group, implying the time component of the coframe to be invariant, and thus to represent a metric time. The unitary gauge fixing of the boosts gives rise to the foliation of spacetime along the time direction. The three supressed degrees of freedom correspond to Goldstone--like fields, whereas the remaining time component is a Higgs--like boson.

  2. In Search of Lost Time

    Science.gov (United States)

    Duncan, Robert A.

    Time is our most familiar means of organizing thought and action, yet it is also the most illusive. Awareness of time as a perceptible one-way flow is a central facet of human consciousness. Everyone knows what time is but anyone would be hard pressed to define it. Is time unidirectional? Does it tick by at a constant rate? How do we measure it? How do we make sense of time before human experience? These are some of the mind-bending questions that Derek York introduces in his short and very readable collection of vignettes about time.

  3. Introduction to Time Series Modeling

    CERN Document Server

    Kitagawa, Genshiro

    2010-01-01

    In time series modeling, the behavior of a certain phenomenon is expressed in relation to the past values of itself and other covariates. Since many important phenomena in statistical analysis are actually time series and the identification of conditional distribution of the phenomenon is an essential part of the statistical modeling, it is very important and useful to learn fundamental methods of time series modeling. Illustrating how to build models for time series using basic methods, "Introduction to Time Series Modeling" covers numerous time series models and the various tools f

  4. Tunneling time in attosecond experiments, intrinsic-type of time. Keldysh, and Mandelstam-Tamm time

    Science.gov (United States)

    Kullie, Ossama

    2016-05-01

    Tunneling time in attosecond and strong-field experiments is one of the most controversial issues in current research, because of its importance to the theory of time, the time operator and the time-energy uncertainty relation in quantum mechanics. In Kullie (2015 Phys. Rev. A 92 052118) we derived an estimation of the (real) tunneling time, which shows an excellent agreement with the time measured in attosecond experiments, our derivation is found by utilizing the time-energy uncertainty relation, and it represents a quantum clock. In this work, we show different aspects of the tunneling time in attosecond experiments, we discuss and compare the different views and approaches, which are used to calculate the tunneling time, i.e. Keldysh time (as a real or imaginary quantity), Mandelstam-Tamm time, the classical view of the time measurement and our tunneling time relation(s). We draw some conclusions concerning the validity and the relation between the different types of the tunneling time with the hope that they will help to answer the question put forward by Orlando et al (2014 J. Phys. B 47 204002, 2014 Phys. Rev. A 89 014102): tunneling time, what does it mean? However, as we will see, the important question is a more general one: how to understand the time and the measurement of the time of a quantum system? In respect to our result, the time in quantum mechanics can be, in more general fashion, classified in two types, intrinsic dynamically connected, and external dynamically not connected to the system, and consequently (perhaps only) classical Newtonian time remains as a parametric type of time.

  5. The Geography of Equity Listing and Financial Centre Competition in Mainland China and Hong Kong

    NARCIS (Netherlands)

    B. Karreman (Bas); G.A. van der Knaap (Bert)

    2010-01-01

    textabstractThis study examines the changing competitiveness of financial centres in mainland China and Hong Kong based on the geography of equity listing of mainland Chinese firms. Pre-listing firm characteristics are used to explore firms’ motives for listing on a particular exchange and whether

  6. The Geography of Equity Listing and Financial Centre Competition in Mainland China and Hong Kong

    NARCIS (Netherlands)

    B. Karreman (Bas); G.A. van der Knaap (Bert)

    2010-01-01

    textabstractThis study examines the changing competitiveness of financial centres in mainland China and Hong Kong based on the geography of equity listing of mainland Chinese firms. Pre-listing firm characteristics are used to explore firms’ motives for listing on a particular exchange and whether t

  7. Timing in the Time Domain: Cygnus X-1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Quantities characterizing temporal property, e.g., power density, co-herence, and time lag, can be defined and calculated directly in the time domain without using the Fourier transformation. Spectral hardness, variability duration,and correlation between different characteristic quantities on different time scale can be studied in the time domain as well. The temporal analysis technique in the time domain is a powerful tool, particularly in studying rapid variability on short time scales (or in high frequencies). Results of studying variabilities of X-rays from Cyg X-1 with the analysis technique in the time domain and RXTE data reveal valu-able clues to understanding production and propagation processes of X-rays and structure of accretion disk in the black hole system.

  8. GPS Position Time Series @ JPL

    Science.gov (United States)

    Owen, Susan; Moore, Angelyn; Kedar, Sharon; Liu, Zhen; Webb, Frank; Heflin, Mike; Desai, Shailen

    2013-01-01

    Different flavors of GPS time series analysis at JPL - Use same GPS Precise Point Positioning Analysis raw time series - Variations in time series analysis/post-processing driven by different users. center dot JPL Global Time Series/Velocities - researchers studying reference frame, combining with VLBI/SLR/DORIS center dot JPL/SOPAC Combined Time Series/Velocities - crustal deformation for tectonic, volcanic, ground water studies center dot ARIA Time Series/Coseismic Data Products - Hazard monitoring and response focused center dot ARIA data system designed to integrate GPS and InSAR - GPS tropospheric delay used for correcting InSAR - Caltech's GIANT time series analysis uses GPS to correct orbital errors in InSAR - Zhen Liu's talking tomorrow on InSAR Time Series analysis

  9. DESIGN TRENDS IN TIMING BELTS

    OpenAIRE

    Grzegorz DOMEK

    2014-01-01

    Paper presents the state of the art gear with timing belts. Areas of use pose new challenges for designers gear. It has materials and technologies used in the production. Has been developed algorithm of design timing belts to new applications

  10. Analysis of the Breakout Time

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Brandon Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-04-15

    The motivation to precisely determine breakout time is to better understand initial motion. An analysis on the baseline is conducted to determine breakout time. The power in the baseline drops by a factor of ~6 after the breakout time occurs. The characteristic rounded step function of the baseline power can be modeled to calculate the breakout time. The characteristic rounded step function of the phase change in the baseline can be modeled to calculate the breakout time. Power and phase both seem to be viable sources that can be used to find breakout time effectively. The phase and power methods complement one another, so whenever one method does not work, the other can still be used. In some cases, the breakout time can be slightly shifted between phase and power. In the future, it would be good to develop a way to quantify the breakout time as well as the associated precision and accuracy.

  11. GPS Position Time Series @ JPL

    Science.gov (United States)

    Owen, Susan; Moore, Angelyn; Kedar, Sharon; Liu, Zhen; Webb, Frank; Heflin, Mike; Desai, Shailen

    2013-01-01

    Different flavors of GPS time series analysis at JPL - Use same GPS Precise Point Positioning Analysis raw time series - Variations in time series analysis/post-processing driven by different users. center dot JPL Global Time Series/Velocities - researchers studying reference frame, combining with VLBI/SLR/DORIS center dot JPL/SOPAC Combined Time Series/Velocities - crustal deformation for tectonic, volcanic, ground water studies center dot ARIA Time Series/Coseismic Data Products - Hazard monitoring and response focused center dot ARIA data system designed to integrate GPS and InSAR - GPS tropospheric delay used for correcting InSAR - Caltech's GIANT time series analysis uses GPS to correct orbital errors in InSAR - Zhen Liu's talking tomorrow on InSAR Time Series analysis

  12. Revuz measures under time change

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper, we shall study how energy functionals and Revuz measures change under time change of Markov processes and provide an intuitive and direct approach to the computation of the Levy system and jumping measure of time changed process.

  13. Organ Type and Waiting Time

    Science.gov (United States)

    ... Kidney/Pancreas Liver Intestine Organ Type and Waiting Time Most candidates, except those with living donors, wait ... organ needed How does organ type affect waiting times? Heart Allocation Physicians assign a status code to ...

  14. Time Warp Operating System (TWOS)

    Science.gov (United States)

    Bellenot, Steven F.

    1993-01-01

    Designed to support parallel discrete-event simulation, TWOS is complete implementation of Time Warp mechanism - distributed protocol for virtual time synchronization based on process rollback and message annihilation.

  15. Analysis of the Breakout Time

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Brandon Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-04-15

    The motivation to precisely determine breakout time is to better understand initial motion. An analysis on the baseline is conducted to determine breakout time. The power in the baseline drops by a factor of ~6 after the breakout time occurs. The characteristic rounded step function of the baseline power can be modeled to calculate the breakout time. The characteristic rounded step function of the phase change in the baseline can be modeled to calculate the breakout time. Power and phase both seem to be viable sources that can be used to find breakout time effectively. The phase and power methods complement one another, so whenever one method does not work, the other can still be used. In some cases, the breakout time can be slightly shifted between phase and power. In the future, it would be good to develop a way to quantify the breakout time as well as the associated precision and accuracy.

  16. Time-adjusted variable resistor

    Science.gov (United States)

    Heyser, R. C.

    1972-01-01

    Timing mechanism was developed effecting extremely precisioned highly resistant fixed resistor. Switches shunt all or portion of resistor; effective resistance is varied over time interval by adjusting switch closure rate.

  17. Time Reference in Different Cultures.

    Science.gov (United States)

    Khairullin, Vladimir

    1993-01-01

    Discusses time references in Russian- and English-speaking cultures by means of Russian translation variants of works by twentieth-century English-language writers. Suggests the different attitudes toward time as manifested by these two distinct cultures. (HB)

  18. Ovation Prime Real-Time

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ovation Prime Real-Time (OPRT) product is a real-time forecast and nowcast model of auroral power and is an operational implementation of the work by Newell et...

  19. Time Warp Operating System (TWOS)

    Science.gov (United States)

    Bellenot, Steven F.

    1993-01-01

    Designed to support parallel discrete-event simulation, TWOS is complete implementation of Time Warp mechanism - distributed protocol for virtual time synchronization based on process rollback and message annihilation.

  20. Time-Space Topology Optimization

    DEFF Research Database (Denmark)

    Jensen, Jakob Søndergaard

    2008-01-01

    A method for space-time topology optimization is outlined. The space-time optimization strategy produces structures with optimized material distributions that vary in space and in time. The method is demonstrated for one-dimensional wave propagation in an elastic bar that has a time-dependent Young......’s modulus and is subjected to a transient load. In the example an optimized dynamic structure is demonstrated that compresses a propagating Gauss pulse....